WorldWideScience

Sample records for current federal role

  1. Federal health web sites: current & future roles.

    Science.gov (United States)

    Cronin, Carol

    2002-09-01

    An examination of the current and possible future roles of federal health Web sites, this paper provides an overview of site categories, functions, target audiences, marketing approaches, knowledge management, and evaluation strategies. It concludes with a look at future opportunities and challenges for the federal government in providing health information online.

  2. Federal role in energy research and development

    International Nuclear Information System (INIS)

    1983-02-01

    The appropriateness of the federal role in each of DOE's major energy R and D programs was evaluated. Several subcriteria were identified by which each program would be judged: (1) the current and expected future scope and amount of private-sector funding relative to requirements for an orderly R and D program; (2) amount of development time to first commercial payoff; (3) degree of market, technical, and policy risks of R and D to private sector development; (4) need for federal energy R and D involvement to support regulatory, environmental, or policy responsibilities. Appropriate primary, complementary, or minimal roles were assigned in each of the energy technology programs: electric-related supply, liquids and gas related supply, conservation and improved end-use utilization, and technology base

  3. The Federal Budget: Current and Upcoming Issues

    Science.gov (United States)

    2009-11-25

    federal revenues, followed by social insurance taxes. Federal individual and corporate income tax revenues typically track broader trends in the...difficult economic conditions led individual income tax revenue to fall to $918 billion (6.5% of GDP ). Corporate income tax revenues fell from $304

  4. Questioning the Federal Role in Educational Research.

    Science.gov (United States)

    Florio, David H.

    1981-01-01

    Reviews the Reagan administration's proposed budget cuts for education, educational research, and social science research. Holds that examples used to bolster the administration's criticisms of social and behavioral research come from the late 1960s/early 1970s, and ignore federally funded work currently focusing on educational practice, policy,…

  5. The US Opioid Crisis: Current Federal and State Legal Issues.

    Science.gov (United States)

    Soelberg, Cobin D; Brown, Raeford E; Du Vivier, Derick; Meyer, John E; Ramachandran, Banu K

    2017-11-01

    The United States is in the midst of a devastating opioid misuse epidemic leading to over 33,000 deaths per year from both prescription and illegal opioids. Roughly half of these deaths are attributable to prescription opioids. Federal and state governments have only recently begun to grasp the magnitude of this public health crisis. In 2016, the Centers for Disease Control and Prevention released their Guidelines for Prescribing Opioids for Chronic Pain. While not comprehensive in scope, these guidelines attempt to control and regulate opioid prescribing. Other federal agencies involved with the federal regulatory effort include the Food and Drug Administration (FDA), the Drug Enforcement Agency (DEA), and the Department of Justice. Each federal agency has a unique role in helping to stem the burgeoning opioid misuse epidemic. The DEA, working with the Department of Justice, has enforcement power to prosecute pill mills and physicians for illegal prescribing. The DEA could also implement use of prescription drug monitoring programs (PDMPs), currently administered at the state level, and use of electronic prescribing for schedule II and III medications. The FDA has authority to approve new and safer formulations of immediate- and long-acting opioid medications. More importantly, the FDA can also ask pharmaceutical companies to cease manufacturing a drug. Additionally, state agencies play a critical role in reducing overdose deaths, protecting the public safety, and promoting the medically appropriate treatment of pain. One of the states' primary roles is the regulation of practice of medicine and the insurance industry within their borders. Utilizing this authority, states can both educate physicians about the dangers of opioids and make physician licensure dependent on registering and using PDMPs when prescribing controlled substances. Almost every state has implemented a PDMP to some degree; however, in addition to mandating their use, increased interstate

  6. Political Change and the Federal Role in Education.

    Science.gov (United States)

    Florio, David H.

    1978-01-01

    The shift in domestic politics away from federal prescriptions is unlikely to have an immediate, radical influence on education policies. The shift is not so much a diminution of the federal role in education as it is a recognition of constraints on the power and influence of federal policy. (DS)

  7. Criteria for Determining an Appropriate Federal Role.

    Science.gov (United States)

    Hawley, Willis D.

    1983-01-01

    Proposes a framework for determining whether federal, state, or local governments should perform certain functions in education. Applies this framework to two areas--curriculum reform and enhanced educational opportunities for children with special needs--and suggests directions for federal policy in these areas. (GC)

  8. BETWEEN EUROPEANIZATION, UNITARISM AND AUTONOMY. REMARKS ON THE CURRENT SITUATION OF FEDERALISM IN AUSTRIA

    Directory of Open Access Journals (Sweden)

    Peter Bußjäger

    2010-04-01

    Full Text Available The following article describes current challenges of Austrian federalism. On ground of the Federal Constitution from 1920 Austria is a federation with nine autonomous Länder. Federalism is one of the basic principles of the constitution. Nevertheless the Länder are faced with centralizing drive due to Europeanization and unitarism. On the other hand the Länder have a strong regional identity. The Länder are emotionally deeply rooted in theAustrian population. The Länder also participate well in the decision making process on European level.Nevertheless the division of competencies both in legislation and administration between Federation and Länder is complicated and needs to be modernised. In the past various reform projects on federal level had failed while various reforms in the Land constitutions have led to more innovation on Land level. Despite these facts paradigms of reform debates on Austria´s federal system have changed: Until the early nineties of 20th century constitutionalreforms aimed to strengthen the role of the Länder. Since Austria´saccession to the EU reform projects the efficiency of the federal structures of Austria are doubted. Economical and financial crisis probably will increase the pressure for structural reforms.

  9. The Emerging Federal Role in Financing Education

    Science.gov (United States)

    Guthrie, James W.

    1972-01-01

    The author predicts that within the next four years we will see another major federal school aid bill which will try to provide for financial equalization both between states and within states, as well as to provide some property-tax relief. (AN)

  10. 31 CFR 321.25 - Role of Federal Reserve Banks.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Role of Federal Reserve Banks. 321.25 Section 321.25 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL.... Federal Reserve Bank of Kansas City, 925 Grand Avenue, Kansas City, MO 64198 Dallas, San Francisco, Kansas...

  11. [The current role of warfarin].

    Science.gov (United States)

    Michalcová, Jana; Buliková, Alena; Zavřelová, Jiřina; Prudková, Marie; Penka, Miroslav

    Well-managed warfarin therapy remains an important method of anticoagulation in the 21st century, despite the introduction of new antithrombotics into the clinical practice. The main advantages of warfarin are decades of treatment experience, the possibility to monitor its anticoagulant effect using the INR and the last, but not least, the low cost. Currently, approximately 75 % of anticoagulated patients in the Czech Republic are treated with warfarin and warfarin remains the only option for oral anticoagulant therapy in certain clinical conditions (particularly in patients with valvular atrial fibrillation or mechanical heart valves). For physicians across specialties it is still indispensable to master the basics of safe and effective warfarin therapy, including the management of treatment complications.Key words: anticoagulant therapy - INR - thrombosis - warfarin.

  12. Health federalism: the role of health care professionals in Nepal.

    Science.gov (United States)

    Dulal, R K

    2009-01-01

    Nepal has entered from its unitary system into a new "Federal Democratic Republic State". The current constitution presents basic health care services as a fundamental right. The Ministry for Health and Population has been providing resources to meet health demands, but managers are wrestling to meet these demands. Persistent disparities between rural and urban and across regions resulted inferior health outcomes, e.g., life expectancy in an urban district like Bhaktapur is 71 years, whereas in the rural district of Mugu it is 44 years. The poor health and poor access to health care in the past systems prompted people to seek a different model. Ultimately, all political parties except one have agreed on federalism. The exact number of federal states that are going to be created is unknown. In federalism, all federated states have to assume certain relationships between the locality, the region, and the nation that apply not only in politics but in health care too. Managing changes in health care organization during the transitional period and after restructuring the unitary Nepal into federal states should be carefully planned. In case, if new system also fails to deliver necessary health care services, the possibility of igniting of dissatisfaction, public unrest and even disintegration cannot be ignored. In order to outline a structure and give life to a health care system under federalism, health care professionals need to engage themselves seriously.

  13. Current environmental situation in the new Federal States. Pt. 1

    International Nuclear Information System (INIS)

    Haury, H.J.; Koller, U.; Assmann, G.

    1992-01-01

    'Information on Environment' organised the first part of a seminar for jounalists on the present environmental situation in the now federal states in Berlin on the 3rd and 4th of December. More than 50 participants from radios, TV, daily and special press attended this ninth event of 'Information on Environment' in Berlin. Leading scientists from research institutes of the former GDR, the Federal Environmental Agency and the GSF-research centre for environment and heath gave papers on the predominant environmental problems in the new federal states. This first part deals with water pollution, waste water treatment, drinking water supply, environmental problems of lignite mining, radiation pollution in the Erzgebirge; forest damage research and special armament wastes and waste problems in general. (orig.) [de

  14. 31 CFR 317.9 - Role of Federal Reserve Banks.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Role of Federal Reserve Banks. 317.9 Section 317.9 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... and control of bond stock, and the accounting for and remittance of sales proceeds; and (4) Providing...

  15. The role of the Federal Relighting Initiative in emission controls

    International Nuclear Information System (INIS)

    Nicholls, A.K.; Purcell, C.W.; Friedman, J.R.

    1992-10-01

    The Department of Energy's (DOE) Federal Relighting Initiative (FRI), under the Federal Energy Management Program (FEMP), has developed a comprehensive process to assist federal agencies in meeting the nation's energy mandate. This mandate states that federal facilities must use 20% less energy by the year 2000, based on 1985 consumption levels. Because lighting accounts for about 40% of total federal electricity consumption, the FRI was conceived to help reduce energy use in this important area while improving lighting quality and increasing productivity through relighting. Selected federal rules and regulations provide guidance on the types of energy efficiency techniques required, life-cycle costing methods and lighting levels that should be employed to achieve the federal mandate. Although the central focus of this paper is on the environment, this paper takes the perspective that the energy efficiency gains achieved through the FRI would produce both environmental and economic benefits for the United States. For example, improvements in energy efficiency would reduce electricity demand, and would consequently reduce the emissions associated with fossil fuel combustion for power production. These reduced emissions include carbon dioxide, which is associated with the potential for global climate change, and heavy metals, which pose a potential health threat to humans and aquatic ecosystems. Economic benefits of the FRI would include reduced federal expenditures on energy or, possibly, avoiding new power plant construction.This paper begins with a brief overview of the FRI process. Next, current lighting energy use in federal buildings is evaluated and the potential future energy savings achievable through full implementation of the FRI are estimated. The paper then translates these energy savings into avoided emissions of carbon dioxide and heavy metals and into avoided fuel expenditures

  16. Evaluating the federal role in financing health-related research.

    Science.gov (United States)

    Garber, A M; Romer, P M

    1996-11-12

    This paper considers the appropriate role for government in the support of scientific and technological progress in health care; the information the federal government needs to make well-informed decisions about its role; and the ways that federal policy toward research and development should respond to scientific advances, technology trends, and changes in the political and social environment. The principal justification for government support of research rests upon economic characteristics that lead private markets to provide inappropriate levels of research support or to supply inappropriate quantities of the products that result from research. The federal government has two basic tools for dealing with these problems: direct subsidies for research and strengthened property rights that can increase the revenues that companies receive for the products that result from research. In the coming years, the delivery system for health care will continue to undergo dramatic changes, new research opportunities will emerge at a rapid pace, and the pressure to limit discretionary federal spending will intensify. These forces make it increasingly important to improve the measurement of the costs and benefits of research and to recognize the tradeoffs among alternative policies for promoting innovation in health care.

  17. National monetary policy by regional design: the evolving role of the Federal Reserve banks in Federal Reserve System policy

    OpenAIRE

    David C. Wheelock

    1999-01-01

    This paper examines the history of Federal Reserve Bank input into Federal Reserve System monetary policymaking. From the Fed's founding in 1914 through the Great Depression, the Reserve Banks held the balance of power. Dissatisfaction with the Fed's performance, however, led to a wholesale reorganization in 1935 that greatly enhanced the authority of the Federal Reserve Board, but retained a role for the Federal Banks through the membership of their presidents on the FOMC, as well as in sett...

  18. Current state of spent fuel management in the Russian Federation

    International Nuclear Information System (INIS)

    Makarchuk, T.F.; Spichev, V.V.; Tikhonov, N.S.; Simanovsky, V.M.; Tokarenko, A.I.; Bespalov, V.N.

    1998-01-01

    Twenty nine power units of nine nuclear power plants of total installed capacity 22 GW(e) are now in operation in the Russian Federation. They produce approximately 12% of electric power in the country. The annual spent fuel arising is about 790 tU. The spent fuel from VVER-440 and BN-600 is reprocessed at the RT-1 plant near Chelyabinsk. The VVER-1000 spent fuel is planned to be reprocessed at the reprocessing plant RT-2 which is under construction near Krasnoyarsk. The RBMK-1000 spent fuel is not reprocessed because of its low fissile content. It is meant to be stored in intermediate storage facilities at the NPP sites and in a centralized storage facility during a period not less than 50 years and then to be disposed of in geological formations. State of the art of spent fuel reprocessing, storage and transportation is considered in the paper. Problems of nuclear fuel cycle back-end in Russia are taken into account. (author)

  19. Federal role and activities in energy research and development 1946-1980: an historical summary

    Energy Technology Data Exchange (ETDEWEB)

    Hewlett, R.G.; Dierenfield, B.J.

    1983-02-01

    The federal role in energy research and development has changed substantially in the three decades since World War II. In nuclear technology, the federal presence shifted from government monopoly in the 1940s and early 1950s, to a lesser federal role in the mid-1950s, as the private sector commercialized nuclear power, to an increasing federal role in the 1960s, but now focused on the breeder reactor as a long-term option. Conventional fuel technologies such as coal and oil enjoyed only modest federal support in the immediate postwar years, with only slow increases before 1974. Renewable energy technologies have received substantial federal support only since 1973.

  20. Federal role and activities in energy research and development 1946-1980: an historical summary

    International Nuclear Information System (INIS)

    Hewlett, R.G.; Dierenfield, B.J.

    1983-02-01

    The federal role in energy research and development has changed substantially in the three decades since World War II. In nuclear technology, the federal presence shifted from government monopoly in the 1940s and early 1950s, to a lesser federal role in the mid-1950s, as the private sector commercialized nuclear power, to an increasing federal role in the 1960s, but now focused on the breeder reactor as a long-term option. Conventional fuel technologies such as coal and oil enjoyed only modest federal support in the immediate postwar years, with only slow increases before 1974. Renewable energy technologies have received substantial federal support only since 1973

  1. 77 FR 71009 - Framework for Pharmacy Compounding: State and Federal Roles

    Science.gov (United States)

    2012-11-28

    ...] Framework for Pharmacy Compounding: State and Federal Roles AGENCY: Food and Drug Administration, HHS... Federal Roles.'' At this public meeting, FDA and State representatives will share their perspectives. Date... would require compliance with Federal standards. In addition, there are open questions about whether...

  2. Shared Solar. Current Landscape, Market Potential, and the Impact of Federal Securities Regulation

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Brockway, Anna M. [U.S. Department of Energy, Washington, DC (United States); Ulrich, Elaine [U.S. Department of Energy, Washington, DC (United States); Margolis, Robert [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2015-04-07

    This report provides a high-level overview of the current U.S. shared solar landscape, the impact that a given shared solar program’s structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  3. Shared Solar. Current Landscape, Market Potential, and the Impact of Federal Securities Regulation

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brockway, Anna M. [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Ulrich, Elaine [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Margolis, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-04-01

    This report provides a high-level overview of the current U.S. shared solar landscape and the impact that a given shared solar program’s structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  4. The Rise of International Relations Programs in the Brazilian Federal Universities: Curriculum Specificities and Current Challenges

    Science.gov (United States)

    Ferreira, Marcos Alan S. V.

    2016-01-01

    The aim of this reflection is to study the new international relations (IR) programs introduced by Brazilian federal universities, looking comparatively at their curriculum specificities and current challenges. In recent years, Brazil has seen an increase of IR programs launched in several regions. Since 2003, the Ministry of Education is in the…

  5. Right to health in Russian Federation: identification of its current stage of constitutional and legal recognition

    Directory of Open Access Journals (Sweden)

    TARASENKO, Elena

    2013-11-01

    Full Text Available Russian Federation has made a strong legal commitment to the human right to health through the ratification of several key international human rights laws. Current public health care policies also demonstrate that Russian Federation has committed itself to provide the human right to health protection of people residing with its jurisdiction. All residents of Russia are eligible for medical care free of charge. Medical services are provided directly to patients by government health care providers. This includes general and specialist medical care, hospitalization, diagnostic laboratory services, dental care, maternity care and transportation, free drugs for disabled, medical rehabilitation, etc. The legal basis for the human right to health at the federal level is provided by a variety of legislative acts (codes, federal laws, presidential decrees, decisions and proposals of the government of the Russian Federation, and orders of the government and of the Ministry of Health and other ministries. The legal bas is at the regional level is provided by legislative instruments enacted by the governments of the Subjects of Russian Federation.

  6. Alternative Conceptions of the Federal Role in Education: Thinking Anew about What to Aid, and How.

    Science.gov (United States)

    Finn, Chester E., Jr.

    1982-01-01

    A critique of federal education policy discusses questionable purposes, flaws in aid-dispensing mechanisms, and undue regulatory burdens and other constraints. The proper federal role in education is described, involving information dissemination, educational improvement through federal programs, compensation, and financial assistance. (CJ)

  7. Managing across levels of government: evaluation of federal-state roles and responsibilities involving nonfederal forests in the United States

    Science.gov (United States)

    Paul V. Ellefson; Calder M. Hibbard; Michael A. Kilgore

    2006-01-01

    With the assistance of state foresters and federal agency executives, an evaluation was made of federal and state government roles and responsibilities focused nonfederal forests in the United States. The evaluation involved an inventory of legally (and administratively) defined federal roles, identification bf federal programs supporting accomplishment of such roles,...

  8. Got junk? The federal role in regulating "competitive" foods.

    Science.gov (United States)

    Salinsky, Eileen

    2009-12-11

    A wide variety of food and beverage items are available in schools in addition to the school meals provided through the National School Lunch Program and School Breakfast Program. A long-standing source of controversy, the need for stronger federal restrictions on foods that compete with school meals is again under debate. This issue brief examines the availability and consumption of competitive foods, explores the regulation of these foods at the federal level, considers trends in state and local restrictions, and summarizes perceived barriers to improving the nutritional quality of competitive food options.

  9. Johannes Althusius' grand federalism, the role of the Ephors and ...

    African Journals Online (AJOL)

    Thereafter follows an exposition of his federalism which consists of a set of associations, beginning with the closest-knit association, namely the family, spiralling out into the most encompassing association, which is the commonwealth or realm, with collegia, cities and provinces in between. The office of the supreme ...

  10. The current role of vascular stents.

    Science.gov (United States)

    Busquet, J

    1993-09-01

    The limitations of percutaneous balloon angioplasty have favoured the development and the use of vascular endoprostheses or stents. These thin-walled metal devices maintain after expansion, an optimal and constant diameter for the vascular lumen. Restenosis, dissection, abrupt closure, residual stenosis or re-opened total occlusion represent appropriate indications for stenting. A large experience with non-coronary application of stents is currently available in iliac, femoro-popliteal and renal arteries, aorta, large veins.

  11. The Federal Role in Adolescent Literacy from Johnson through Obama: A Policy Regimes Analysis

    Science.gov (United States)

    Hauptli, Meghan V.; Cohen-Vogel, Lora

    2013-01-01

    This article examines the federal role in adolescent literacy from its roots in Lyndon B. Johnson's administration with the Economic Opportunity Act (1964) through the Reading for Understanding grants of 2010. The authors consider the extent to which the recent attention to and changes in the federal approach to adolescent literacy can be…

  12. The role of the states in a federal climate program : issues and options

    Science.gov (United States)

    2009-11-01

    This paper provides an overview of some of the key isuses regarding statefederal roles in a federal climate program and identifies four possible mechanisms that have been suggested for allowing states to set more stringent reduction targets. *Cont...

  13. General Conformity Training Module 2.5: Proactive Role for Federal Agencies

    Science.gov (United States)

    Module 2.5 explains how taking a proactive role will allow a federal agency to more effectively participate in newly promulgated programs under the General Conformity Regulations, such as the emission reduction credits and the emission budgets programs.

  14. No Global War? A Role for Democratic Global Federalism

    Directory of Open Access Journals (Sweden)

    Myron J. Frankman

    2015-08-01

    Full Text Available In fact, the issue is not whether we shall be governed globally, but rather by whom and on what basis. The international realm is not one of anarchy as the realists would have us believe, but rather one of order: of rules, procedures and accepted norms of behavior associated in part with what are termed "international regimes" (Krasner 1983, each dedicated in principle to a separate functional domain. Global governance is not something that is to be created, but rather something to be altered in the public interest. The governance of the globe is currently configured by a shifting set of ill-coordinated actors: among them the one remaining super-power and, to a lesser extent, other strong states, as well as powerful individuals and a number of large transnational corporations and financial institutions. Whereas Le Monde Diplomatique (1995 speaks oflcs nouveaux maitres du monde, Robert Cox has summed up our current system of global governance with the phrase nebuleuse: "There is, in effect, no explicit political or authority structure for the global economy. There is, nevertheless, something there that remains to be deciphered, something that could be described by the French word nebulcuse or by the notion of 'governance without government."'

  15. THE ROLE OF IDSTORY IN UNDERSTANDING CURRENT SOUTH ...

    African Journals Online (AJOL)

    ... Afr. J. Env. Ed. No. 10 (1989;. 3. THE ROLE OF IDSTORY IN UNDERSTANDING CURRENT SOUTH AFRICAI''r ... decision~making and socially responsive action by the ... physical and emotional estrangement of Africans by making it illegal ...

  16. Technical roles and success of US federal laboratory-industry partnerships

    OpenAIRE

    Barry Bozeman; Dennis Wittmer

    2001-01-01

    Drawing from questionnaire-based data of 229 US federal laboratory-industry joint R&D projects, this research examines the composition of the technical interaction by character of the R&D performed to determine the impacts on effectiveness of the technical roles played by research partners. In addition to the particular technical roles, their number and diversity are examined, giving particular attention to the subset of projects in which the company played no technical role. Our findings sho...

  17. Education and the Economy: A Diagnostic Review and Implications for the Federal Role.

    Science.gov (United States)

    Berryman, Sue E.

    Changes in the American economy and in the nature and organization of work fundamentally challenge the educational system and have implications for the Federal Government's role. Case studies of the insurance, banking, and textile industries demonstrate the following changes in the nature and structure of work: (1) both service and manufacturing…

  18. 31 CFR 359.71 - What is the role of Federal Reserve Banks and Branches?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What is the role of Federal Reserve Banks and Branches? 359.71 Section 359.71 Money and Finance: Treasury Regulations Relating to Money and... Boulevard, Kansas City, MO 64106 Dallas, San Francisco, Kansas City, St. Louis Alaska, Arizona, Arkansas...

  19. 31 CFR 351.86 - What is the role of Federal Reserve Banks and Branches?

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What is the role of Federal Reserve Banks and Branches? 351.86 Section 351.86 Money and Finance: Treasury Regulations Relating to Money and... Kansas City, 925 Grand Boulevard, Kansas City, MO 64106 Dallas, San Francisco, Kansas City, St. Louis...

  20. ANALYSIS OF THE CURRENT STATE OF THE BUDGET SYSTEM OF THE RUSSIAN FEDERATION

    Directory of Open Access Journals (Sweden)

    Vladimir V. Bandurin

    2015-01-01

    Full Text Available The article analyzes the budgetary system of the Russian Federation. The elements of the budgetary system and the types of fiscal federalism. Particular attention is paid to the problem of the audit (control budget formulation and execution, the external and internal state financial control. 

  1. Toxic substances: Federal-provincial control. Revised edition. Current issue review No. 88-11E

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, K; Johansen, D

    1993-01-01

    There is widespread public concern about the effect of toxic substances on human health and the environment. This document looks at the federal-provincial control on toxic substances. It specifically examines the control of toxic substances under the Canadian constitution; the political arena; the federal- provincial co-operation; the Green Plan; and the 1991 Auditor General's Report.

  2. Economic security of the Russian Federation: current status, level and threats

    Directory of Open Access Journals (Sweden)

    V. V. Grigoryeva

    2017-01-01

    Full Text Available The problems of national and economic security maintenanceis aggravating in modern conditions of globalization and international competition related to controlof market channels, technological, information and natural resources.Today Russia is making all efforts to protect its position on the world stage and improve the lives of its citizens.Despite the worsening of the present economic, political and social differences in the world, the Russian Federation has its own national interests, which can be possible to fulfill only on the basis of sustainable development of the national economic security system.The latter traditionally determines the ability of the state economic system to maintain normal conditions for the national economy functioning and the population activity. The national economic securitystabilitycan be estimated only by the application of elaborate tools of the economic development indicators analysis and the threshold values examinationaimed at the determination of the quality characteristic of actual and the most successful model of the economic activity.The analysis of the current Russian economic situation showed the presence of some serious problems existing in the national economy. The economic security level of Russia, having a tendency to increase in the period of 1998-2013, has been sharply reduced to critical points since 2014. So, it is necessary to take some measures to restructure the system of economic security of the state. Based on the research it was identified the list of the most dangerous threats to the modern Russian economy, which includes: low level of the country industrial production; the economy dependence on goods import and raw materials export; low living standards of the population; the rapid growth of the shadow economy and corruption; the lack of civil science and innovationdevelopment. The main strategic directions for economic security levelincrease in Russia today and in the future are aimed at

  3. Shared Solar: Current Landscape, Market Potential, and the Impact of Federal Securities Regulation; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-27

    This presentation provides a high-level overview of the current U.S. shared solar landscape, the impact that a given shared solar program's structure has on requiring federal securities oversight, as well as an estimate of market potential for U.S. shared solar deployment.

  4. THE CURRENT STATE OF SEED PRODUCTION OF VEGETABLES AND GOURDS IN RUSSIAN FEDERATION; NATIONAL FOOD SAFETY

    Directory of Open Access Journals (Sweden)

    S. M. Sirota

    2017-01-01

    Full Text Available The current state of seed market of vegetable and gourds in Russian Federation in the frame of national food safety program is given in the article. Russia as a country with well-developed  seed production  in the last century has now  ceded  its  position,  and according  to  last experts’ association estimations the 80%  of  required volume of seeds of vegetables and gourds, amounting from 8 to 12 thousand per year is imported.  Not  less than 15 thousands  of  hectares  are  needed  to  be  necessary  for demand  of  Russian seed  production  sector,  however, presently only 2 thousands of hectares is a total certified land used for seed production.  Moreover, the seed production sector of some countries that export seeds rises becoming a profitable branch of agriculture, and providing local employment. The lack of competitiveness in Russia causes that many foreign companies increase annually purchasing prices for seeds and their production services. Therefore, now the total volume of seeds imported  in  Russian Federation has nearly been  twice less for the last years than in 2012, but in currency earnings in exporting countries the insignificant changes can be seen, where deviation is only 19-25%  from  average annual value, that means 1675 thousand dollars per year. Besides, for the Russian budget in the ruble currency the total cost of imported seeds has become 2.5 times more expensive since 2012, but the increase of combined cost of  marketable  vegetables  has been  over  2.7  billion  of rubles.  The  main  idea  that  the  seed  production  is  a process requiring the participation of breeders, seed producers and seed companies is main factor to succeed in recovering seed production sector. Exception of any participant or ignoring his interests may destroy all process. For instance, there is a chronic problem of plagiarism and royalty nonpayment causes the break between the business and

  5. Current status of radon and radium monitoring at the Federal University of Technology (UTFPR), PR, Brazil

    International Nuclear Information System (INIS)

    Paschuk, Sergei A.; Correa, Janine N.; Kappke, Jaqueline; Schelin, Hugo R.; Denyak, Valeriy; Barbosa, Laercio; Perna, Allan F.N.

    2011-01-01

    Numerous and systematic studies performed in different countries for many decades resulted in the explicit conclusion that radon exposure, as well as its progeny, is the main cause of lung cancer among non-smokers. All three natural radon isotopes ( 222 Rn, 220 Rn and 219 Rn) are produced in the three principal natural radioactive decay chains. Specifically, the 222 Rn is produced by the decay series of 238 U and proceeded from α-decay of 226 Ra. Current work describes the present status and obtained results concerning indoor radon survey in dwellings, radon in water supply and soil gas tests performed by the Laboratory of Applied Nuclear Physics of the Federal University of Technology (UTFPR) within Curitiba urban area. For radon in air activity measurements, it was used polycarbonate etched track detectors such as LEXAN (GE) and CR-39, mounted in diffusion chambers. For soil gas measurements, the experimental setup was based on the Professional Radon Monitor (AlphaGUARD, Genitron/SAPHYMO) connected to the air pump with filter vessels and to specially developed in our Laboratory the Soil Gas Probe. In the case of radon tests in drinking water, the experimental setup was based on the AlphaGUARD Radon monitor and Electronic radon detector RAD7 (Durridge Company, Inc.) connected to special kit of glass vessels through the air pump. Obtained results permitted to identify few dwellings where radon concentration in air was found bigger than 600 Bq/m 3 which is considered as the action level by most of the European Community and the World Health Organization (WHO). In the case of studied artesian wells, collected samples of water presented the average 222 Rn activity about 60 Bq/L which is 6 times bigger than maximum level recommended by USEPA. Some artesian wells presented the radon activity of almost 200 Bq/L. More over, it was identified the radioactivity of radium ( 226 Ra) salts which are soluble in water and almost all water samples presented results bigger than

  6. Role of adsorbates on current fluctuations in DC field emission

    International Nuclear Information System (INIS)

    Luong, M.; Bonin, B.; Long, H.; Safa, H.

    1996-01-01

    Field emission experiments in DC regime usually show important current fluctuations for a fixed electric field. These fluctuations are attributed to adsorbed layers (molecules or atoms), liable to affect the work function, height and shape of the potential barrier binding the electron in the metal. The role of these adsorbed species is investigated by showing that the field emission from a well desorbed sample is stable and reproducible and by comparing the emission from the same sample before and after desorption. (author)

  7. Genuine federalism in the Russian health care system: changing roles of government.

    Science.gov (United States)

    Chernichovsky, D; Potapchik, E

    1999-02-01

    The reforms that have affected the Russian health care system since the breakup of the Soviet Union, principally those in the general administration of the Russian Federation, have suffered from inconsistency and the absence of a strategy. The various reforms have caused a shift from a national health system characterized by highly centralized management and control, typical of the totalitarian uniform state, to a highly decentralized but fragmented multitude of state systems. Each of these systems is relatively centralized at the local level and run by local administrations with limited government infrastructure and experience. The role of government in the emerging system, and in particular the role of the federal government, remains ill defined. As a result, there is a grave risk that the Russian health care system may disintegrate as a national system. This undermines (a) the prevailing universal and fairly equitable access to care, (b) stabilization of the system following a long period of transition, and (c) the long-term reform that is required to bring the Russian health care system up to par with the health care systems in other developed countries. A rapid transition to a genuine federal health system with well-articulated roles for different levels of government, in tandem with implementation of the 1993 Compulsory Health Insurance System, is essential for the stabilization and reform of the Russian health care system.

  8. The role of surface currents in plasma confinement

    International Nuclear Information System (INIS)

    Webster, Anthony J.

    2011-01-01

    During plasma instabilities, ''surface currents'' can flow at the interface between the plasma and the surrounding vacuum, and in most cases, they are a harmless symptom of the instability that is causing them. Large instabilities can lead to ''disruptions,'' an abrupt termination of the plasma with the potential to damage the machine in which it is contained. For disruptions, the correct calculation of surface currents is thought to be essential for modelling disruptions properly. Recently, however, there has been debate and disagreement about the correct way to calculate surface currents. The purpose of this paper is to clarify as simply as possible the role of surface currents for plasma confinement and to show that a commonly used representation for surface currents σ-vector with σ-vector=∇I and n-vector, I a scalar function, and n-vector the unit normal to the plasma surface, is only appropriate for the calculation of surface currents that are in magnetohydrodynamic equilibrium. Fortunately, this is the situation thought to be of most relevance for disruption calculations.

  9. The current role of simulation in urological training.

    Science.gov (United States)

    Preece, Ryan

    2015-01-01

    Simulation is becoming an increasingly popular educational tool in numerous surgical specialities, including urology. This article reviews the current role of urological simulators; discussing their need, availability, incorporation and current limitations. A literature review of the electronic databases Medline, Embase and Google Scholar was performed. For increasingly limited urological training programs, simulation can act as a valuable adjunct to clinical training. Evidence suggests that simulation enables the trainee to bypass the early, error-prone part of the surgical learning curve. It should be incorporated into proficiency-based curricula, with junior trainees initially beginning with low fidelity simulators to grasp basic surgical skills before moving onto full-procedural simulation as they progress through their training. A wide variety of simulators of differing fidelity are currently available, teaching both technical (eg. cystoscopy) and non-technical (eg. communication) urological surgical skills. Whist numerous studies have assessed the face, content and construct validity of various urological simulators, further work needs to be undertaken to determine whether the skills learnt actually improve trainee performance in the operating room. Then, educators will be able to make informed decisions about whether these resource demanding (financially and in terms of demands on faculty) simulators are a worthwhile educational tool. Although further investigation is required, urological simulators appear to have a considerable role for developing both technical and non-technical urological skills in an increasingly restricted educational environment in modern urogynecology.

  10. "Current Good Manufacturing Practices" and the Federal Food, Drug and Cosmetic Act

    OpenAIRE

    Goldstein, Beth F.

    1995-01-01

    The Food and Drug Administration (hereinafter, FDA) regulates food, drugs, and cosmetics in order to ensure that these products are safe and truthfully labelled. As part of its responsibilities under the Federal Food, Drug, and Cosmetic Act (hereinafter, Act), the FDA monitors the manufacturing practices of companies involved in the production of food, drugs, and medical devices. The manufacturing practices used by these companies must comply with certain standards, identified in the Act as "...

  11. The Brazilian Audit Tribunal's role in improving the federal environmental licensing process

    International Nuclear Information System (INIS)

    Lima, Luiz Henrique; Magrini, Alessandra

    2010-01-01

    This article describes the role played by the Brazilian Audit Tribunal (Tribunal de Contas da Uniao - TCU) in the external auditing of environmental management in Brazil, highlighting the findings of an operational audit conducted in 2007 of the federal environmental licensing process. Initially, it records the constitutional and legal framework of Brazilian environmental licensing, describing the powers and duties granted to federal, state and municipal institutions. In addition, it presents the responsibilities of the TCU in the environmental area, comparing these with those of other Supreme Audit Institutions (SAI) that are members of the International Organization of Supreme Audit Institutions (INTOSAI). It also describes the work carried out in the operational audit of the Brazilian environmental licensing process and its main conclusions and recommendations. Finally, it draws a parallel between the findings and recommendations made in Brazil with those of academic studies and audits conducted in other countries.

  12. Ionizing radiation protection regulation in Canada: the role of the Federal Provincial Territorial Radiation Protection Committee

    International Nuclear Information System (INIS)

    Clement, Christopher H.

    2008-01-01

    Canada has one of the broadest and most mature nuclear industries in the world, and is a world leader in uranium mining, and in the production of medical radioisotopes. The Canadian nuclear industry also includes: uranium milling, refining, and fuel fabrication facilities; nuclear generating stations; research reactors and related facilities; waste management facilities; and the use of radioactive materials in medicine and industry. Regulation of this broad and dynamic industry is a complex and challenging task. Canada has a cooperative system for the regulation of ionizing radiation protection covering federal, provincial, territorial, and military jurisdictions. A Federal/Provincial/Territorial Radiation Protection Committee (FPTRPC) exists to aid in cooperation between the various agencies. Their mandate encompasses regulation and guidance on all aspects of radiation protection: federal and provincial; NORM and anthropogenic; ionizing and non-ionizing. The Canadian Nuclear Safety Commission (CNSC) is the federal nuclear regulator whose mandate includes radiation protection regulation of most occupational and public exposures. The CNSC does not regulate medical (patient) exposures, some aspects of NORM, or military applications. Provincial authorities are the primary regulators with respect to doses to patients and occupational doses arising from X-rays. Health Canada plays a role in X-ray device certification, development of national guidance (e.g. on radon) and direct regulation of certain federal facilities. NORM is regulated provincially, with varying regulatory mechanisms across the provinces and territories. Radiation protection regulation for National Defence and the Canadian Armed Forces is performed by the Director General Nuclear Safety. This paper gives an overview of the structure of the regulation of ionizing radiation protection in Canada, and shares lessons learned, particularly with respect to the usefulness of the FPTRPC in helping coordinate and

  13. Current Grid operation and future role of the Grid

    Science.gov (United States)

    Smirnova, O.

    2012-12-01

    Grid-like technologies and approaches became an integral part of HEP experiments. Some other scientific communities also use similar technologies for data-intensive computations. The distinct feature of Grid computing is the ability to federate heterogeneous resources of different ownership into a seamless infrastructure, accessible via a single log-on. Like other infrastructures of similar nature, Grid functioning requires not only technologically sound basis, but also reliable operation procedures, monitoring and accounting. The two aspects, technological and operational, are closely related: weaker is the technology, more burden is on operations, and other way around. As of today, Grid technologies are still evolving: at CERN alone, every LHC experiment uses an own Grid-like system. This inevitably creates a heavy load on operations. Infrastructure maintenance, monitoring and incident response are done on several levels, from local system administrators to large international organisations, involving massive human effort worldwide. The necessity to commit substantial resources is one of the obstacles faced by smaller research communities when moving computing to the Grid. Moreover, most current Grid solutions were developed under significant influence of HEP use cases, and thus need additional effort to adapt them to other applications. Reluctance of many non-HEP researchers to use Grid negatively affects the outlook for national Grid organisations, which strive to provide multi-science services. We started from the situation where Grid organisations were fused with HEP laboratories and national HEP research programmes; we hope to move towards the world where Grid will ultimately reach the status of generic public computing and storage service provider and permanent national and international Grid infrastructures will be established. How far will we be able to advance along this path, depends on us. If no standardisation and convergence efforts will take place

  14. Current Grid operation and future role of the Grid

    International Nuclear Information System (INIS)

    Smirnova, O

    2012-01-01

    Grid-like technologies and approaches became an integral part of HEP experiments. Some other scientific communities also use similar technologies for data-intensive computations. The distinct feature of Grid computing is the ability to federate heterogeneous resources of different ownership into a seamless infrastructure, accessible via a single log-on. Like other infrastructures of similar nature, Grid functioning requires not only technologically sound basis, but also reliable operation procedures, monitoring and accounting. The two aspects, technological and operational, are closely related: weaker is the technology, more burden is on operations, and other way around. As of today, Grid technologies are still evolving: at CERN alone, every LHC experiment uses an own Grid-like system. This inevitably creates a heavy load on operations. Infrastructure maintenance, monitoring and incident response are done on several levels, from local system administrators to large international organisations, involving massive human effort worldwide. The necessity to commit substantial resources is one of the obstacles faced by smaller research communities when moving computing to the Grid. Moreover, most current Grid solutions were developed under significant influence of HEP use cases, and thus need additional effort to adapt them to other applications. Reluctance of many non-HEP researchers to use Grid negatively affects the outlook for national Grid organisations, which strive to provide multi-science services. We started from the situation where Grid organisations were fused with HEP laboratories and national HEP research programmes; we hope to move towards the world where Grid will ultimately reach the status of generic public computing and storage service provider and permanent national and international Grid infrastructures will be established. How far will we be able to advance along this path, depends on us. If no standardisation and convergence efforts will take place

  15. FEDERAL SUPPORT OF SCIENTIFIC INQUIRY IN THE UNITED STATES: CURRENT EVOLUTION UNDER THE POLITICAL STRUGGLE

    Directory of Open Access Journals (Sweden)

    I. A. Istomin

    2016-01-01

    Full Text Available 2000’s and 2010’s witnessed diminishing margin of the United States in science and technology. Meanwhile, the U.S. remains a clear leader in this fi eld. Major driving force of the country’s success in the second half of the ХХ century remained assertive federal science policy. The article seeks to identify major trends in evolution of the U.S. science policy and the reasons behind relative decline of the level of budget support of the scientifi c research. The author studies evolution of the policies of George Bush and Barack Obama, as well as the views of Democrats and Republicans in the House of Representatives and the Senate. The article also examines the input into the federal policy of the governmental bodies, which are directly responsible for its implementation, as well as non-governmental organizations, which seek to advocate interests of scientists; it studies rising competition between the executive authorities and legislators for the recognition as a major champion of the academic community as well as American Recovery and Reinvestment Act.

  16. Role of the Russian Federation in the Settlement of the Nagorno-Karabakh Conflict

    Directory of Open Access Journals (Sweden)

    H L Paronyan

    2013-12-01

    Full Text Available The article examines the role and the mediation efforts of Russian Federation, aimed at the settlement of the Karabakh conflict, as well as the activity of the OSCE Minsk group (today that is Russia, the United States and France, engaged in the settlement of the Nagorno-Karabakh conflict in 1992. In the conditions of intransigence of positions between conflicting parties, international mediation acquires particular significance in the settlement of the conflict. In opinion of both Armenian and Russian sides, the format of OSCE Minsk group is mostly responsible for the further settlement of the Karabakh conflict.

  17. PHILANTHRPY AND ITS ROLE IN FORMING CIVIL SOCIETY IN RUSSIAN FEDERATION

    Directory of Open Access Journals (Sweden)

    V. R. Goryatcheva

    2012-01-01

    Full Text Available The institution of philanthropy is an important part of any civil society. The article provides definition of a charity institution and stresses the important role of legislation in the development of philanthropy. Legislation in the field of philanthropy in the Russian Federation, including mainlegal acts and the taxation system of non-governmental non-commercial organizations, are discussed. Essential tax deductions for charitable work lead to the emergence of patterns of tax evasion, including withdrawal of funds to offshore areas.

  18. The role of the Federal Trade Commission in advertising health products and services.

    Science.gov (United States)

    Daynard, Matthew

    2004-01-01

    The Federal Trade Commission plays a unique role in enforcing well-established standards ensuring that consumers can make informed purchase and use decisions about health-related products and services based on truthful, non-misleading advertising claims while encouraging competition. Deceptive and unfair practices are defined. The importance of the "net impression" that ads convey to consumers and the need for substantiation of objective, factual claims is explained. The FTC uses its enforcement powers and consumer and industry outreach to create a climate for preventing misleading advertising.

  19. Childhood abuse and current interpersonal conflict: the role of shame.

    Science.gov (United States)

    Kim, Jungmeen; Talbot, Nancy L; Cicchetti, Dante

    2009-06-01

    To examine whether shame-proneness mediates the relationship between women's histories of childhood sexual abuse and their current partner and family conflict and child maltreatment. Previous research has found that women with childhood sexual abuse histories experience heightened shame and interpersonal conflict. However, research examining the relationship of shame to interpersonal conflict is lacking. Participants were 129 mothers of children enrolled in a summer camp program for at-risk children from financially disadvantaged families. Data were collected on women's childhood abuse histories, shame in daily life, and current interpersonal conflict involving family conflict, intimate partner conflict (verbal and physical aggression), and child maltreatment. Consistent with our hypothesis, the results of hierarchical regressions and logistic regression indicated that shame significantly mediated the association between childhood sexual abuse and interpersonal conflict. Women with sexual abuse histories reported more shame in their daily lives, which in turn was associated with higher levels of conflicts with intimate partners (self-verbal aggression and partner-physical aggression) and in the family. Shame did not mediate the relationship between mothers' histories of sexual abuse and child maltreatment. The role of shame in the intimate partner and family conflicts of women with sexual abuse histories has not been examined. The current findings indicate that childhood sexual abuse was related to interpersonal conflicts indirectly through the emotion of shame. These findings highlight the importance of investigating the role of shame in the interpersonal conflicts of women with histories of childhood sexual abuse. Healthcare professionals in medical and mental health settings frequently treat women with abuse histories who are involved in family and partner conflicts. Assessing and addressing the links of abused women's shame to interpersonal conflicts could be

  20. Childhood Abuse and Current Family Conflict: The Role of Shame

    Science.gov (United States)

    Kim, Jungmeen; Talbot, Nancy L.; Cicchetti, Dante

    2014-01-01

    Objective To examine whether shame-proneness mediates the relationship between women's histories of childhood sexual abuse and their current partner and family conflict and child maltreatment. Previous research has found that women with childhood sexual abuse histories experience heightened shame and interpersonal conflict. However, research examining the relationship of shame to interpersonal conflict is lacking. Method Participants were 129 mothers of children enrolled in a summer camp program for at-risk children from financially disadvantaged families. Data were collected on women's childhood abuse histories, shame in daily life, and current interpersonal conflict involving family conflict, intimate partner conflict (verbal and physical aggression), and child maltreatment. Results Consistent with our hypothesis, the results of hierarchical regressions and logistic regression indicated that shame significantly mediated the association between childhood sexual abuse and interpersonal conflict. Women with sexual abuse histories reported more shame in their daily lives, which in turn was associated with higher levels of conflicts with intimate partners (self-verbal aggression and partner-physical aggression) and in the family. Shame did not mediate the relationship between mothers' histories of sexual abuse and child maltreatment. Conclusion The role of shame in the intimate partner and family conflicts of women with sexual abuse histories has not been examined. The current findings indicate that childhood sexual abuse was related to interpersonal conflicts indirectly through the emotion of shame. Practical Implications These findings highlight the importance of investigating the role of shame in the interpersonal conflicts of women with histories of childhood sexual abuse. Healthcare professionals in medical and mental health settings frequently treat women with abuse histories who are involved in family and partner conflicts. Assessing and addressing the links of

  1. The EarthServer Federation: State, Role, and Contribution to GEOSS

    Science.gov (United States)

    Merticariu, Vlad; Baumann, Peter

    2016-04-01

    The intercontinental EarthServer initiative has established a European datacube platform with proven scalability: known databases exceed 100 TB, and single queries have been split across more than 1,000 cloud nodes. Its service interface being rigorously based on the OGC "Big Geo Data" standards, Web Coverage Service (WCS) and Web Coverage Processing Service (WCPS), a series of clients can dock into the services, ranging from open-source OpenLayers and QGIS over open-source NASA WorldWind to proprietary ESRI ArcGIS. Datacube fusion in a "mix and match" style is supported by the platform technolgy, the rasdaman Array Database System, which transparently federates queries so that users simply approach any node of the federation to access any data item, internally optimized for minimal data transfer. Notably, rasdaman is part of GEOSS GCI. NASA is contributing its Web WorldWind virtual globe for user-friendly data extraction, navigation, and analysis. Integrated datacube / metadata queries are contributed by CITE. Current federation members include ESA (managed by MEEO sr.l.), Plymouth Marine Laboratory (PML), the European Centre for Medium-Range Weather Forecast (ECMWF), Australia's National Computational Infrastructure, and Jacobs University (adding in Planetary Science). Further data centers have expressed interest in joining. We present the EarthServer approach, discuss its underlying technology, and illustrate the contribution this datacube platform can make to GEOSS.

  2. Results of operation and current safety performance of nuclear facilities located in the Russian Federation

    Science.gov (United States)

    Kuznetsov, V. M.; Khvostova, M. S.

    2016-12-01

    After the NPP radiation accidents in Russia and Japan, a safety statu of Russian nuclear power plants causes concern. A repeated life time extension of power unit reactor plants, designed at the dawn of the nuclear power engineering in the Soviet Union, power augmentation of the plants to 104-109%, operation of power units in a daily power mode in the range of 100-70-100%, the use of untypical for NPP remixed nuclear fuel without a careful study of the results of its application (at least after two operating periods of the research nuclear installations), the aging of operating personnel, and many other management actions of the State Corporation "Rosatom", should attract the attention of the Federal Service for Ecological, Technical and Atomic Supervision (RosTekhNadzor), but this doesn't happen. The paper considers safety issues of nuclear power plants operating in the Russian Federation. The authors collected statistical information on violations in NPP operation over the past 25 years, which shows that even after repeated relaxation over this period of time of safety regulation requirements in nuclear industry and highly expensive NPP modernization, the latter have not become more safe, and the statistics confirms this. At a lower utilization factor high-power pressure-tube reactors RBMK-1000, compared to light water reactors VVER-440 and 1000, have a greater number of violations and that after annual overhauls. A number of direct and root causes of NPP mulfunctions is still high and remains stable for decades. The paper reveals bottlenecks in ensuring nuclear and radiation safety of nuclear facilities. Main outstanding issues on the storage of spent nuclear fuel are defined. Information on emissions and discharges of radioactive substances, as well as fullness of storages of solid and liquid radioactive waste, located at the NPP sites are presented. Russian NPPs stress test results are submitted, as well as data on the coming removal from operation of NPP

  3. The role of women in the political life of the Federation of Bosnia and Herzegovina

    Directory of Open Access Journals (Sweden)

    Marić-Tokić Silvana

    2017-01-01

    Full Text Available As a human activity, politics has long been intended for men only, with women and other minority groups not being allowed to participate in either the social or the political life of the community. Starting in the 1970s, the role of woman within our social and political life strengthened in several countries, but only with legal and incentive measures. The role of women in Bosnian -Herzegovinian society, public life, does not meet the quotas introduced in 1997, which require a 40% women involvement in politics. The research covers the period from 2016 since the last election to date. The aim of the research was to determine the level of representation of women in the political life of BiH at the Federation of BiH, cantonal and local level, respectively. The key hypothesis of this paper is as follows: Is the low level of representation within political bodies of the Federation of BiH, cantonal and local level, respected? Research has shown that women in the BiH Federation are not sufficiently represented in political life. In terms of percentage, no part of the survey pertaining to prime locations, ministerial posts, mayor's seats, and mayors meets the prescribed quota of women's representation in politics being 40%. The Bosnian - Herzegovinian society, if it wants to go in the direction of progress and development, and democratic society, must increase the participation of women in social and political life. Only those societies and states that exclude all forms of discrimination and increase human rights, especially women's rights, as equal members of the community can call themselves democratic and developed societies.

  4. Current and Potential Use of Technology Forecasting Tools in the Federal Government

    Science.gov (United States)

    2016-03-01

    in a stand-alone fashion . vii Contents 1. Introduction... consultations with subject matter experts. The respondents at GAO expressed that one of their most significant challenges is forecasting the global economic...supplant the role of the analyst, and it should not be operated in a stand-alone fashion . In the following chapter, the specific capabilities of

  5. History and current activities of the International Diabetes Federation-Western Pacific Region (IDF-WPR).

    Science.gov (United States)

    Baba, S

    1994-10-01

    International Diabetes Federation (IDF) is one of the biggest non-governmental organizations with its 44-year history since 1950. In 1993, 114 diabetes associations in 96 countries participated in the IDF. In 1982, it was decided to divide the globe into seven regions and to promote the diagnosis, treatment, care and education of diabetes based on the environment, natural features, culture and race of the each region. On January 24, 1984, the IDF-WPR establishment meeting was held in Melbourne, Australia, with eight original member countries (Australia, New Zealand, Korea, The Philippines, Malaysia, Singapore, Fiji and Japan). In 1993, 13 diabetes associations in 12 countries joined the IDF-WPR. New member associations are from China (Beijing and Taipei), Hong Kong, Papua New Guinea and Indonesia. The IDF-WPR has been holding congresses and council meetings every 3 or 4 years since 1984 as well as formulating strategic action plans in the scientific, clinical, health care and education fields of diabetes.

  6. The Influence of Mother-Daughter Relationships on Women's Sense of Self and Current Role Choices.

    Science.gov (United States)

    Sholomskas, Diane; Axelrod, Rosalind

    1986-01-01

    Investigates the relationship of women's current role choices, role satisfaction, and self-esteem to their perceptions of the earlier relationship with their mothers and to their perceptions of their mothers' role choices and role satisfaction. (Author/ABB)

  7. CURRENT TRENDS OF THE PROVISION FOR RADIATION SAFETY OF THE POPULATION OF THE RUSSIAN FEDERATION

    Directory of Open Access Journals (Sweden)

    G. G. Onishenko

    2014-01-01

    Full Text Available P.V.Ramzaev”The article is devoted to the actual issues ofRussian Federationpopulation radiation safety providing at the present stage. The important role of radiation-hygienic passportization is underlined in the process of the obtaining of objective information of radiation situation in the country, of population exposure doses from the all sources: artificial and natural, from the use of ionizing irradiation sources in medicine. The leading role is shown of the natural ionizing irradiation sources in the level of the country population exposure. The main directions of activities are stated aimed on the decreasing of population exposure doses from the natural sources. The brief characteristics is given of the radiation situation on the territories radioactively contaminated after the accident on the Chernobyl NPP, in the Pacific Ocean basin after the accident on the “Fukushima-1”NPP, of the main measures for radiation protection providing and for counteraction to radiation terrorism during the period of international sports and mass actions which were carried out in Russia in the last years (XXVII World Summer Universiade in2013 inKazan, XXII Olympic and XI Winter Paralympics Games in2014 inSochi. The most important tasks are defined for the improvement ofRussian Federationpopulation radiation safety at the present stage.

  8. 28 CFR 1100.29 - The roles and responsibilities of federal law enforcement, immigration, and Department of State...

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false The roles and responsibilities of federal... OF STATE TRAFFICKING IN PERSONS Victims of Severe Forms of Trafficking in Persons § 1100.29 The roles... in persons, and are familiar with the rights, services, and protections such victims are to be...

  9. Place and Role of Customs Bodies of the Russian Federation in Ensuring Economic Security of the State

    Directory of Open Access Journals (Sweden)

    Alexey A. Buzlov

    2017-03-01

    Full Text Available In this article author considers basics of economic security of the state, analyzes the role of the customs bodies of the Russian Federation. Author analyzes some international and national acts, opinions of scientists and practitioners. Attention is drawn to restrictions of political and economic nature imposed on the Russian Federation, officials, state and commercial organizations. In the conclusion author draws attention to some of the problems that exist in law enforcement practice.

  10. Role of pelvic and para-aortic lymphadenectomy in endometrial cancer: Current evidence

    Science.gov (United States)

    Bogani, Giorgio; Dowdy, Sean C.; Cliby, William A.; Ghezzi, Fabio; Rossetti, Diego; Mariani, Andrea

    2015-01-01

    The aim of the present review is to summarize the current evidence on the role of pelvic and para-aortic lymphadenectomy in endometrial cancer. In 1988, the International Federation of Obstetrics and Gynecology recommended surgical staging for endometrial cancer patients. However, 25 years later, the role of lymph node dissection remains controversial. Although the findings of two large independent randomized trials suggested that pelvic lymphadenectomy provides only adjunctive morbidity with no clear influence on survival outcomes, the studies have many pitfalls that limit interpretation of the results. Theoretically, lymphadenectomy may help identify patients with metastatic dissemination, who may benefit from adjuvant therapy, thus reducing radiation-related morbidity. Also, lymphadenectomy may eradicate metastatic disease. Because lymphatic spread is relatively uncommon, our main effort should be directed at identifying patients who may potentially benefit from lymph node dissection, thus reducing the rate of unnecessary treatment and associated morbidity. This review will discuss the role of lymphadenectomy in endometrial cancer, focusing on patient selection, extension of the surgical procedure, postoperative outcomes, quality of life and costs. The need for new surgical studies and efficacious systemic drugs is recommended. PMID:24472047

  11. Conflict between civil liberties and nuclear energy safeguards: an analysis of current and prospective Federal regulation

    International Nuclear Information System (INIS)

    O'Brien, J.N.

    1977-01-01

    The high regard that the U.S. has traditionally placed on individual rights and liberties makes it imperative that nuclear-safeguards measures currently in use or suggested by evaluated in terms of their social costs. A nuclear-safeguards strategy that minimizes civil-liberties impacts as a social cost and allows adequate protection against the threats of nuclear theft and sabotage in the rapidly developing nuclear energy industry must be arrived at. This study explores the possible civil-liberties impacts and the effectiveness of nuclear-safeguards measures which may be or are being used. Case law and statutory law are extensively analyzed to classify the type of civil-liberties impacts that particular nuclear-safeguards measures may impose. Literature addressing the effectiveness of safeguards measures is examined in various contexts often completely outside of the ''security'' disciplines. A comparison of both the civil liberties impact and effectiveness of each nuclear safeguards measure reveals a cost/benefit factor from which conclusions may be drawn. The real issue is whether or not a nuclear safeguards system will interfere with historic respect governmental institutions have given rights and liberties guaranteed in the U.S. It is concluded that physical access controls present only minor civil liberties costs while providing substantial protection against theft and sabotage. Recommendations are made in the form of suggested statutes, regulations, and regulatory guides. Certain inter-agency relationships and methods for establishing those relationships are also suggested

  12. The Role of Diasporas in the Current World Politics

    Directory of Open Access Journals (Sweden)

    Ivan D. Loshkariov

    2015-01-01

    Full Text Available The author's intention is to access the impact that diasporas have on world politics. The notion “diaspora” implies a transnational migrant community, which maintains material and emotional bonds with territory of origin and simultaneously adapts to limitations and possibilities of host society. The emotional component of a community entails psychosocial complex that includes the group solidarity and certain myths about the territory of origin. Taking into account the specifics of a given community, diasporas meet in general all the requirements of a non-state actor that have been elaborated in the current studies on the world politics. In particular, a diasporas exist independently and participates in the transnational interactions. Moreover, there are several situations which enhance diaspora’s ability to interfere. These situations may include the unsatisfactory status of the given community, migrants’ desire to improve certain political or economic conditions in the territory of origin, the prerequisites for changes in the relationships between the hostland and the homeland, urgent crises in the country of origin. In addition, diasporal influence depends on demographic and geographic characteristics of the particular community. Diasporas achieve their goals on global, regional and national levels mainly by influencing state’s institutions. However, some developments have been evolved that can facilitate a substantive diasporas’ involvement in the world political processes, involvement without dependence on state’s capabilities. Elite of the community plays a crucial role in the resource management. The elite presents “the controlling centre” that forges a strategy of action and makes transactions of resources. Stability within “the controlling centre” can be named as an indicator of diaspora’s ability to manage the potential available.

  13. The Role of the Federal Standard in the Beneficial Use of Dredged Material

    Science.gov (United States)

    A guide for USACE Districts, other federal agencies, state agencies, local governments, and private interest groups. The Federal Standard Paper provides guidance on using dredged material as a resource to achieve environmental and economic benefits.

  14. Radioprotective drugs: a synopsis of current research and a proposed research plan for the Federal Emergency Management Agency. Final report

    International Nuclear Information System (INIS)

    Hickman, R.; Anspaugh, L.

    1985-04-01

    FEMA has broad roles in the management of disasters potentially involving substantial amounts of radioactive contamination. These could be either peacetime or wartime disasters. A meeting was held in March 1985 to see if there are any research contributions that FEMA might reasonably make in the area of radioprotective drugs that would substantially enhance its ability to perform its mission. The other federal agencies presently sponsoring research in the field were represented at the meeting. A few selected researchers also participated to provide complementary viewpoints. Activities of a modest scale that FEMA might undertake were identified, as were larger scale activities that might be undertaken in the event of long-term, major funding-level increases for FEMA. 2 refs

  15. Federal roles to realize national energy-efficiency opportunities in the 1990s

    Science.gov (United States)

    Hirst, Eric

    1989-10-01

    Improving energy efficiency throughout the U.S. economy is a vital component of our nation's energy future, with many benefits. Improving efficiency can: save money consumers, increase economic productivity and international competitiveness, reduce oil and gas prices by reducing the demand for foreign oil, enhance national security by lowering oil imports, reduce the adverse environmental consequences of fuel cycles, especially acid rain and global warming, add diversity and flexibility to the nation's portfolio of energy resources, respond to public interest in, and support of, energy efficiency. The primary purpose of this report is to suggest expanded roles for the U.S. Department of Energy (DOE) in improving energy efficiency during the 1990s. In an ideal world, the normal workings of the market place would yield optimal energy-efficiency purchase and operating decisions. Unfortunately, distortions in fuel prices, limited access to capital, misplaced incentives, lack of information, and difficulty in processing information complicate energy-related decision making. Thus, consumers in all sectors of the economy underinvest in energy-efficient systems. These market barriers, coupled with growing concern about environmental quality, justify a larger Federal role.

  16. 29 CFR 1471.135 - May the Federal Mediation and Conciliation Service exclude a person who is not currently...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false May the Federal Mediation and Conciliation Service exclude....135 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1471.135 May the Federal Mediation and...

  17. THE FATHER´S ROLE IN CURRENT FAMILY

    OpenAIRE

    NERADOVÁ, Iveta

    2013-01-01

    This bachelor thesis deals with role of father in contemporary family. The theoretical part consists of three chapters. The first chapter deals with family, its functions and characteristics with regard to the present. The second chapter is focused on parenting. Attention is especially devoted to father, his tasks in child's life, differences in father-son and father-daughter relationship and absence of the father in child´s life. The third chapter deals with issue of gender and gender roles,...

  18. The role of ocean currents for carbonate platform stratigraphy (Invited)

    Science.gov (United States)

    Betzler, C.; Lindhorst, S.; Luedmann, T.; Eberli, G. P.; Reijmer, J.; Huebscher, C. P.

    2013-12-01

    Breaks and turnovers in carbonate bank growth and development record fluctuations in sea-level and environmental changes. For the carbonate banks of the Bahamas, the Maldives, the Queensland, and the Marion Plateau, sea-level changes and synchronous oceanographic and atmospheric circulation events were recorded through compositional and architectural changes. Most of these major carbonate edifices contain drift deposits, indicating that oceanic currents were a major driver of carbonate-bank evolution. It is proposed that such currents have a larger imprint on the growth patterns and the stratigraphic packaging of carbonates than previously thought. In the Bahamas, slope facies of carbonate banks exposed to deep oceanic currents are not arranged into sediment-texture controlled and depth-dependant strike-continuous facies belts. Facies patterns are controlled by the interplay of shallow-water input, succeeding sediment sorting as well as redistribution and erosion processes. This complements the classical windward - leeward classification of carbonate platform slopes and accounts for the significant and potentially dominant process of alongslope sediment transport and dispersal. Deep oceanic currents also have the potential to steepen the carbonate bank slopes, through sediment winnowing at the distal slope, such as for example in the Maldives. This process can be enhanced as the bank grows and expands in size which may accelerate currents. Oceanic current onset or amplification, however, may also account for slope steepening as an externally, i.e. climate-driven agent, thus forcing the banks into an aggradation mode of growth which is not a response to sea-level fluctuations or a result of the windward / leeward exposure of the bank edge. Ignorance of the impact of currents on platforms and platform slopes may lead to an erroneous conclusion that changes in sediment production, distribution, and morphologies of sediment bodies are features solely related to sea

  19. Role of magnetic shear on the electrostatic current driven ion ...

    Indian Academy of Sciences (India)

    It is widely recognized that the electric field plays an important role in the ... They consider a uniform zero order magnetic field (i.e., B ..... the Department of Ocean Development, Govt. of India, New Delhi for financial support through a project.

  20. Childhood Abuse and Current Interpersonal Conflict: The Role of Shame

    Science.gov (United States)

    Kim, Jungmeen; Talbot, Nancy L.; Cicchetti, Dante

    2009-01-01

    Objective: To examine whether shame-proneness mediates the relationship between women's histories of childhood sexual abuse and their current partner and family conflict and child maltreatment. Previous research has found that women with childhood sexual abuse histories experience heightened shame and interpersonal conflict. However, research…

  1. The role of melatonin in the light of current knowledge

    Directory of Open Access Journals (Sweden)

    Barbara Algiert

    2016-02-01

    Full Text Available Recent studies have shed new light on the role of melatonin. Local tissue synthesis has been investigated. A special system responsible for the synthesis and metabolism of melatonin has developed in the human skin. The primary role of melatonin is the regulation of circadian rhythms, but studies have demonstrated the diversity of its activities. Potent antioxidant action of melatonin in the skin is emphasized. The skin has developed a specific antioxidant melatoninergic system which protects against oxidative stress. Presence of melatonin metabolites in the skin confirms its strong antioxidant properties. Melatonin has the ability to restore the physiological balance between synthesis and degradation of extracellular matrix proteins by induction of heme oxygenase in murine fibroblasts irradiated with UVR. There is a hypothesis concerning the participation of melatonin in etiology of vitiligo. Disturbances of melatonin skin synthesis and dysregulation of its receptors may explain the pathogenesis of disease.

  2. Role of Urine Drug Testing in the Current Opioid Epidemic.

    Science.gov (United States)

    Mahajan, Gagan

    2017-12-01

    While the evidence for urine drug testing for patients on chronic opioid therapy is weak, the guidelines created by numerous medical societies and state and federal regulatory agencies recommend that it be included as one of the tools used to monitor patients for compliance with chronic opioid therapy. To get the most comprehensive results, clinicians should order both an immunoassay screen and confirmatory urine drug test. The immunoassay screen, which can be performed as an in-office point-of-care test or as a laboratory-based test, is a cheap and convenient study to order. Limitations of an immunoassay screen, however, include having a high threshold of detectability and only providing qualitative information about a select number of drug classes. Because of these restrictions, clinicians should understand that immunoassay screens have high false-positive and false-negative rates. Despite these limitations, though, the results can assist the clinician with making preliminary treatment decisions. In comparison, a confirmatory urine drug test, which can only be performed as a laboratory-based test, has a lower threshold of detectability and provides both qualitative and quantitative information. A urine drug test's greater degree of specificity allows for a relatively low false-negative and false-positive rate in contrast to an immunoassay screen. Like any other diagnostic test, an immunoassay screen and a confirmatory urine drug test both possess limitations. Clinicians must keep this in mind when interpreting an unexpected test result and consult with their laboratory when in doubt about the meaning of the test result to avoid making erroneous decisions that negatively impact both the patient and clinician.

  3. Role of plasma equilibrium current in Alfven wave antenna optimization

    International Nuclear Information System (INIS)

    Puri, S.

    1986-12-01

    The modifications in the antenna loading produced by the plasma equilibrium current, the Faraday shield, and the finite electron temperature for coupling to the Alfven waves are studied using a self-consistent, three-dimensional, fully analytic periodic-loop-antenna model. The only significant changes are found to occur due to the plasma current and consist of an improved coupling (by a factor of ∝ 2.5) at low toroidal numbers (n ∝ 1-3). Despite this gain, however, the coupling to low n continues to be poor with R=0.03 Ω and Q=180 for n=2. Optimum coupling with R=0.71 Ω and Q=16.8 occurs for n=8 as was also the case in the absence of the plasma current. For the large n values, mode splitting due to the removal of the poloidal degeneracy combined with the finite electron temperatures effects lead to significant broadening of the energy absorption profile. Direct antenna coupling to the surface shear wave is small and no special provision, such as Faraday shielding, may be needed for preventing surface losses. The introduction of the Faraday screen, in fact, increases the coupling to the surface shear wave, possibly by acting as an impedance matching transformer between the antenna and the plasma. The finite electron temperature causes the predictable increase in the absorption width without influencing the antenna coupling. Thus the recommendations for antenna design for optimum coupling to the Alfven wave remain unaffected by the inclusion of the plasma current. Efficient coupling with capabilities for dynamic impedance tracking through purely electronic means may be obtained using a dense-cluster-array antenna with a toroidal configuration of n ∝ 8. (orig.)

  4. Current role of melatonin in pediatric neurology: clinical recommendations.

    Science.gov (United States)

    Bruni, Oliviero; Alonso-Alconada, Daniel; Besag, Frank; Biran, Valerie; Braam, Wiebe; Cortese, Samuele; Moavero, Romina; Parisi, Pasquale; Smits, Marcel; Van der Heijden, Kristiaan; Curatolo, Paolo

    2015-03-01

    Melatonin, an indoleamine secreted by the pineal gland, plays a key role in regulating circadian rhythm. It has chronobiotic, antioxidant, anti-inflammatory and free radical scavenging properties. A conference in Rome in 2014 aimed to establish consensus on the roles of melatonin in children and on treatment guidelines. The best evidence for efficacy is in sleep onset insomnia and delayed sleep phase syndrome. It is most effective when administered 3-5 h before physiological dim light melatonin onset. There is no evidence that extended-release melatonin confers advantage over immediate release. Many children with developmental disorders, such as autism spectrum disorder, attention-deficit/hyperactivity disorder and intellectual disability have sleep disturbance and can benefit from melatonin treatment. Melatonin decreases sleep onset latency and increases total sleep time but does not decrease night awakenings. Decreased CYP 1A2 activity, genetically determined or from concomitant medication, can slow metabolism, with loss of variation in melatonin level and loss of effect. Decreasing the dose can remedy this. Animal work and limited human data suggest that melatonin does not exacerbate seizures and might decrease them. Melatonin has been used successfully in treating headache. Animal work has confirmed a neuroprotective effect of melatonin, suggesting a role in minimising neuronal damage from birth asphyxia; results from human studies are awaited. Melatonin can also be of value in the performance of sleep EEGs and as sedation for brainstem auditory evoked potential assessments. No serious adverse effects of melatonin in humans have been identified. Copyright © 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  5. The role of metformin in ovulation induction: Current status

    OpenAIRE

    Elnashar, Aboubakr Mohamed

    2011-01-01

    To define the exact role of metformin in ovulation induction, it is crucial to distinguish three different indications: naïve PCOS, CC-resistant PCOS and ART. In naïve PCOS: metformin as compared to placebo has been shown to improve ovulation rates, but metformin did not exert significant advantage over CC with respect to cumulative ovulation, pregnancy or live-birth rates. The combined approach of metformin plus CC is not better than CC or metformin monotherapy in naïve PCOS. In CC-resistant...

  6. Current role of lung scintigraphy in pulmonary embolism

    International Nuclear Information System (INIS)

    Giordano, A.; Angiolillo, D. J.

    2001-01-01

    The pivotal role of lung scintigraphy in the diagnosis of pulmonary embolism (PE) has been questioned in recent years due to the introduction of spiral computed tomography. However, the scintigraphic results used for comparisons are often those of the authoritative PIOPED (Prospective Investigation of Pulmonary Embolism Diagnosis) study, carried out in the 1980s. Pulmonary scintigraphy has progressed from those years both in the methodological and interpretative fields, although perhaps too slowly. Results better than those of PIOPED's have been presented by study groups who used: 1) perfusion-only approach; 2) SPET imaging; 3) new interpretative criteria; 4) different prediction rules to integrate clinical and scintigraphic probabilities of PE. These advances are still insufficiently recognised by the nuclear medicine community, possibly due to a sort of PIOPED-based cultural globalisation. This paper reviews the actual advantages and limitations of nuclear medicine techniques, the diagnostic role of scintigraphy within the diagnostic algorithms proposed by international working groups and scientific societies and the results obtained from SPET imaging in the diagnosis of PE

  7. Toxic substances: Federal-provincial control -- rev. revised edition. Current issue review No. 88-11E

    Energy Technology Data Exchange (ETDEWEB)

    Douglas, K

    1994-12-31

    This document provides a background and analysis on federal-provincial control of toxic substances, including their control under the Canadian Constitution, legislation passed by both levels of government, political aspects, federal-provincial cooperation, the Green Plan, and the Auditor General`s report. Parliamentary action taken and a chronology of events are also included.

  8. Conversion of spin current into charge current in a topological insulator: Role of the interface

    Science.gov (United States)

    Dey, Rik; Prasad, Nitin; Register, Leonard F.; Banerjee, Sanjay K.

    2018-05-01

    Three-dimensional spin current density injected onto the surface of a topological insulator (TI) produces a two-dimensional charge current density on the surface of the TI, which is the so-called inverse Edelstein effect (IEE). The ratio of the surface charge current density on the TI to the spin current density injected across the interface defined as the IEE length was shown to be exactly equal to the mean free path in the TI determined to be independent of the electron transmission rate across the interface [Phys. Rev. B 94, 184423 (2016), 10.1103/PhysRevB.94.184423]. However, we find that the transmission rate across the interface gives a nonzero contribution to the transport relaxation rate in the TI as well as to the effective IEE relaxation rate (over and above any surface hybridization effects), and the IEE length is always less than the original mean free path in the TI without the interface. We show that both the IEE relaxation time and the transport relaxation time in the TI are modified by the interface transmission time. The correction becomes significant when the transmission time across the interface becomes comparable to or less than the original momentum scattering time in the TI. This correction is similar to experimental results in Rashba electron systems in which the IEE relaxation time was found shorter in the case of direct interface with metal in which the interface transmission rate will be much higher, compared to interfaces incorporating insulating oxides. Our results indicate the continued importance of the interface to obtain a better spin-to-charge current conversion and a limitation to the conversion efficiency due to the quality of the interface.

  9. The Role of Wakes in Modelling Tidal Current Turbines

    Science.gov (United States)

    Conley, Daniel; Roc, Thomas; Greaves, Deborah

    2010-05-01

    The eventual proper development of arrays of Tidal Current Turbines (TCT) will require a balance which maximizes power extraction while minimizing environmental impacts. Idealized analytical analogues and simple 2-D models are useful tools for investigating questions of a general nature but do not represent a practical tool for application to realistic cases. Some form of 3-D numerical simulations will be required for such applications and the current project is designed to develop a numerical decision-making tool for use in planning large scale TCT projects. The project is predicated on the use of an existing regional ocean modelling framework (the Regional Ocean Modelling System - ROMS) which is modified to enable the user to account for the effects of TCTs. In such a framework where mixing processes are highly parametrized, the fidelity of the quantitative results is critically dependent on the parameter values utilized. In light of the early stage of TCT development and the lack of field scale measurements, the calibration of such a model is problematic. In the absence of explicit calibration data sets, the device wake structure has been identified as an efficient feature for model calibration. This presentation will discuss efforts to design an appropriate calibration scheme which focuses on wake decay and the motivation for this approach, techniques applied, validation results from simple test cases and limitations shall be presented.

  10. Addressing Public Stigma and Disparities Among Persons With Mental Illness: The Role of Federal Policy

    OpenAIRE

    Cummings, Janet R.; Lucas, Stephen M.; Druss, Benjamin G.

    2013-01-01

    Stigma against mental illness is a complex construct with affective, cognitive, and behavioral components. Beyond its symbolic value, federal law can only directly address one component of stigma: discrimination.

  11. Role of diffusion weighted imaging in musculoskeletal infections: Current perspectives

    International Nuclear Information System (INIS)

    Kumar, Yogesh; Khaleel, Mohammad; Boothe, Ethan; Awdeh, Haitham; Wadhwa, Vibhor; Chhabra, Avneesh

    2017-01-01

    Accurate diagnosis and prompt therapy of musculoskeletal infections are important prognostic factors. In most cases, clinical history, examination and laboratory findings help one make the diagnosis, and routine magnetic resonance imaging (MRI) is useful to identify the extent of the disease process. However, in many situations, a routine MRI may not be specific enough especially if the patient cannot receive contrast intravenously, thereby delaying the appropriate treatment. Diffusion-weighted imaging (DWI) can help in many such situations by providing additional information, accurate characterization and defining the extent of the disease, so that prompt treatment can be initiated. In this article, we illustrate the imaging findings of the spectrum of musculoskeletal infections, emphasizing the role of DWI in this domain. (orig.)

  12. [Nitrates in cardiology: current role and areas of uncertainty].

    Science.gov (United States)

    Bellisarii, Francesco Iachini; Muscente, Francesca; Radico, Francesco; Appignani, Marianna; De Caterina, Raffaele

    2011-01-01

    Nitrates have been commonly used in the therapy of cardiovascular disease for more than 150 years. In spite of this longevity and the popularity of their use, it appears somewhat paradoxical that their use is not consistent among cardiologists, both as to their indications and as to their mode of administration. In part this results from their contradictory pharmacodynamics: when given acutely, their effectiveness is indisputable; however, their long-term efficacy is substantially limited by the development of tolerance and the induction of endothelial dysfunction, which may have negative prognostic implications. This review, reporting the most recent biochemical and pathophysiological acquisitions, re-examines the role of nitrates in cardiovascular medicine, reporting, comparing and commenting international guidelines.

  13. Role of diffusion weighted imaging in musculoskeletal infections: Current perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Yogesh [Yale New Haven Health System at Bridgeport Hospital, Department of Radiology, Bridgeport, CT (United States); Khaleel, Mohammad [UT Southwestern Medical Center, Department of Orthopaedic Surgery, Dallas, TX (United States); Boothe, Ethan; Awdeh, Haitham [UT Southwestern Medical Center, Department of Radiology, Dallas, TX (United States); Wadhwa, Vibhor [University of Arkansas for Medical Sciences, Department of Radiology, Little Rock, AR (United States); Chhabra, Avneesh [UT Southwestern Medical Center, Department of Orthopaedic Surgery, Dallas, TX (United States); UT Southwestern Medical Center, Department of Radiology, Dallas, TX (United States)

    2017-01-15

    Accurate diagnosis and prompt therapy of musculoskeletal infections are important prognostic factors. In most cases, clinical history, examination and laboratory findings help one make the diagnosis, and routine magnetic resonance imaging (MRI) is useful to identify the extent of the disease process. However, in many situations, a routine MRI may not be specific enough especially if the patient cannot receive contrast intravenously, thereby delaying the appropriate treatment. Diffusion-weighted imaging (DWI) can help in many such situations by providing additional information, accurate characterization and defining the extent of the disease, so that prompt treatment can be initiated. In this article, we illustrate the imaging findings of the spectrum of musculoskeletal infections, emphasizing the role of DWI in this domain. (orig.)

  14. The Role of States in Cleanup of Hazardous Waste at Federal Facilities

    Science.gov (United States)

    1993-09-01

    law. In this case the plaintiffs were engaged in the business of growing, packing, and marketing avocados in Florida. They brought suit in federal court...production, marketing and distribution of electric power in the Pacific Northwest. The Council’s responsibility was to develop a plan for... Avocado Growers, Inc. v. Paul.’-9 In this case the Supreme Court set forth a three-part test to determine if a state law had been preempted by a federal

  15. The role of metformin in ovulation induction: Current status

    Directory of Open Access Journals (Sweden)

    Aboubakr Mohamed Elnashar

    2011-09-01

    Full Text Available To define the exact role of metformin in ovulation induction, it is crucial to distinguish three different indications: naïve PCOS, CC-resistant PCOS and ART. In naïve PCOS: metformin as compared to placebo has been shown to improve ovulation rates, but metformin did not exert significant advantage over CC with respect to cumulative ovulation, pregnancy or live-birth rates. The combined approach of metformin plus CC is not better than CC or metformin monotherapy in naïve PCOS. In CC-resistant patients: metformin has no benefit over placebo in ovulation, pregnancy, and live-birth rates as a single agent, but the combination of metformin and CC significantly improved ovulation and pregnancy rates when compared with CC alone. However, combined therapy did not improve the odds of live birth. Metformin pretreatment improves the efficacy of CC in PCOS patients with CC resistance. In PCOS patients scheduled for ART: metformin addition to gonadotropins reduces the duration of gonadotropins administration and the doses of gonadotropins required, and increases the rate of monoovulations, reducing the risk of cancelled cycles. Metformin co-administration to IVF treatment does not improve pregnancy or live-birth rates but reduces the risk of OHSS.

  16. The role of pharmacoeconomics in current Indian healthcare system.

    Science.gov (United States)

    Ahmad, Akram; Patel, Isha; Parimilakrishnan, Sundararajan; Mohanta, Guru Prasad; Chung, HaeChung; Chang, Jongwha

    2013-01-01

    Phamacoeconomics can aid the policy makers and the healthcare providers in decision making in evaluating the affordability of and access to rational drug use. Efficiency is a key concept of pharmacoeconomics, and various strategies are suggested for buying the greatest amount of benefits for a given resource use. Phamacoeconomic evaluation techniques such as cost minimization analysis, cost effectiveness analysis, cost benefit analysis, and cost utilization analysis, which support identification and quantification of cost of drugs, are conducted in a similar way, but vary in measurement of value of health benefits and outcomes. This article provides a brief overview about pharmacoeconomics, its utility with respect to the Indian pharmaceutical industry, and the expanding insurance system in India. Pharmacoeconomic evidences can be utilized to support decisions on licensing, pricing, reimbursement, and maintenance of formulary procedure of pharmaceuticals. For the insurance companies to give better facility at minimum cost, India must develop the platform for pharmacoeconomics with a validating methodology and appropriate training. The role of clinical pharmacists including PharmD graduates are expected to be more beneficial than the conventional pharmacists, as they will be able to apply the principles of economics in daily basis practice in community and hospital pharmacy.

  17. The current role of radiotherapy in colorectal cancer

    International Nuclear Information System (INIS)

    Aleman, B.M.P.; Bartelink, H.; Gunderson, L.L.

    1995-01-01

    During the last two decades, radiotherapy has become an integral part of the multidisciplinary approach in the treatment of patients with colorectal cancer. Currently, radiotherapy is seen mainly as an adjuvant therapy, sometimes in combination with chemotherapy, in a pre- or post-operative setting. Adjuvant radiotherapy alone leads to a significant reduction of local recurrence rates, but an impact on survival is seen only in subset analyses. Combined modality treatment can reduce local recurrence rates even further, and can also reduce the rate of distant relapses and increase survival. The acute toxicity of combined modality is considerably higher. Local radiation can also be used as a component of organ conserving local treatment for selected early lesions. Radiotherapy has been an important palliative treatment modality, diminishing symptoms in cases of inoperable primary rectal cancers or pelvic recurrences. The timing of radiation, surgery and chemotherapy has been under evaluation for years. For patients with locally advanced primary or recurrent malignancies (unresectable due to fixation), the preferred sequence is pre-operative irradiation with or without chemotherapy, followed by surgical resection. For mobile resectable lesions, sequencing issues are being tested in phase III randomised trials. (author)

  18. Assessing readability of patient education materials: current role in orthopaedics.

    Science.gov (United States)

    Badarudeen, Sameer; Sabharwal, Sanjeev

    2010-10-01

    Health literacy is the single best predictor of an individual's health status. It is important to customize health-related education material to the individual patient's level of reading skills. Readability of a given text is the objective measurement of the reading skills one should possess to understand the written material. In this article, some of the commonly used readability assessment tools are discussed and guidelines to improve the comprehension of patient education handouts are provided. Where are we now? Several healthcare organizations have recommended the readability of patient education materials be no higher than sixth- to eighth-grade level. However, most of the patient education materials currently available on major orthopaedic Web sites are written at a reading level that may be too advanced for comprehension by a substantial proportion of the population. WHERE DO WE NEED TO GO?: There are several readily available and validated tools for assessing the readability of written materials. While use of audiovisual aids such as video clips, line drawings, models, and charts can enhance the comprehension of a health-related topic, standard readability tools cannot construe such enhancements. HOW DO WE GET THERE?: Given the variability in the capacity to comprehend health-related materials among individuals seeking orthopaedic care, stratifying the contents of patient education materials at different levels of complexity will likely improve health literacy and enhance patient-centered communication.

  19. The role of simulation in teaching pediatric resuscitation: current perspectives

    Directory of Open Access Journals (Sweden)

    Lin Y

    2015-03-01

    Full Text Available Yiqun Lin,1 Adam Cheng2 1KidSIM-ASPIRE Simulation Research Program, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada; 2KidSIM-ASPIRE Research Program, Department of Pediatrics, Division of Emergency Medicine, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada Abstract: The use of simulation for teaching the knowledge, skills, and behaviors necessary for effective pediatric resuscitation has seen widespread growth and adoption across pediatric institutions. In this paper, we describe the application of simulation in pediatric resuscitation training and review the evidence for the use of simulation in neonatal resuscitation, pediatric advanced life support, procedural skills training, and crisis resource management training. We also highlight studies supporting several key instructional design elements that enhance learning, including the use of high-fidelity simulation, distributed practice, deliberate practice, feedback, and debriefing. Simulation-based training is an effective modality for teaching pediatric resuscitation concepts. Current literature has revealed some research gaps in simulation-based education, which could indicate the direction for the future of pediatric resuscitation research. Keywords: simulation, pediatric resuscitation, medical education, instructional design, crisis resource management, health care

  20. Current role of radiation therapy for multiple myeloma.

    Science.gov (United States)

    Talamo, Giampaolo; Dimaio, Christopher; Abbi, Kamal K S; Pandey, Manoj K; Malysz, Jozef; Creer, Michael H; Zhu, Junjia; Mir, Muhammad A; Varlotto, John M

    2015-01-01

    Radiation therapy (RT) is a treatment modality traditionally used in patients with multiple myeloma (MM), but little is known regarding the role and effectiveness of RT in the era of novel agents, i.e., immunomodulatory drugs and proteasome inhibitors. We retrospectively reviewed data from 449 consecutive MM patients seen at our institute in 2010-2012 to assess indications for RT as well as its effectiveness. Pain response was scored similarly to RTOG 0631 and used the Numerical Rating Pain Scale. Among 442 evaluable patients, 149 (34%) patients and 262 sites received RT. The most common indication for RT was palliation of bone pain (n = 109, 42%), followed by prevention/treatment of pathological fractures (n = 73, 28%), spinal cord compression (n = 26, 10%), and involvement of vital organs/extramedullary disease (n = 25, 10%). Of the 55 patients evaluable for pain relief, complete and partial responses were obtained in 76.4 and 7.2%, respectively. Prior RT did not significantly decrease the median number of peripheral blood stem cells collected for autologous transplant, even when prior RT was given to both the spine and pelvis. Inadequacy of stem cell collection for autologous stem cell transplant (ASCT) was not significantly different and it occurred in 9 and 15% of patients receiving no RT and spine/pelvic RT, respectively. None of the three cases of therapy-induced acute myelogenous leukemia/MDS occurred in the RT group. Despite the introduction of novel effective agents in the treatment of MM, RT remains a major therapeutic component for the management in 34% of patients, and it effectively provides pain relief while not interfering with successful peripheral blood stem cell collection for ASCT.

  1. Current Role of Computer Navigation in Total Knee Arthroplasty.

    Science.gov (United States)

    Jones, Christopher W; Jerabek, Seth A

    2018-01-31

    Computer-assisted surgical (CAS) navigation has been developed with the aim of improving the accuracy and precision of total knee arthroplasty (TKA) component positioning and therefore overall limb alignment. The historical goal of knee arthroplasty has been to restore the mechanical alignment of the lower limb by aligning the femoral and tibial components perpendicular to the mechanical axis of the femur and tibia. Despite over 4 decades of TKA component development and nearly 2 decades of interest in CAS, the fundamental question remains; does the alignment goal and/or the method of achieving that goal affect the outcome of the TKA in terms of patient-reported outcome measures and/or overall survivorship? The quest for reliable and reproducible achievement of the intraoperative alignment goal has been the primary motivator for the introduction, development, and refinement of CAS navigation. Numerous proprietary systems now exist, and rapid technological advancements in computer processing power are stimulating further development of robotic surgical systems. Three categories of CAS can be defined: image-based large-console navigation; imageless large-console navigation, and more recently, accelerometer-based handheld navigation systems have been developed. A review of the current literature demonstrates that there are enough well-designed studies to conclude that both large-console CAS and handheld navigation systems improve the accuracy and precision of component alignment in TKA. However, missing from the evidence base, other than the subgroup analysis provided by the Australian Orthopaedic Association National Joint Replacement Registry, are any conclusive demonstrations of a clinical superiority in terms of improved patient-reported outcome measures and/or decreased cumulative revision rates in the long term. Few authors would argue that accuracy of alignment is a goal to ignore; therefore, in the absence of clinical evidence, many of the arguments against

  2. Role of the Federal Radiological Monitoring and Assessment Center (FRMAC) following a radiological accident

    International Nuclear Information System (INIS)

    Doyle, J.F. III.

    1986-01-01

    The Federal Radiological Emergency Response Plan (FRERP) calls for the Department of Energy to establish a Federal Radiological Monitoring and Assessment Center (FRMAC) immediately following a major radiological accident to coordinate all federal off-site monitoring efforts in support of the State and the Cognizant Federal Agency (CFA) for the facility or material involved in the accident. Some accidents are potentailly very complex and may require hundreds of radiation specialists to ensure immediate protection of the public and workers in the area, and to identify priorities for the Environmental Protection Agency (EPA) long-term efforts once the immediate protective actions have been carried out. The FRMAC provides a working environment with today's high technology tools (i.e., communication, computers, management procedures, etc.) to assure that the State and CFA decision makers have the best possible information in a timely manner on which to act. The FRMAC planners also recognize an underlying responsibility to continuously document such operations in order to provide the State, the CFA, and the EPA the technical information they will require for long term assessments. In addition, it is fully recognized that information collected and actions taken by the FRMAC will be subjected to the same scrutiny as other parts of the accident and the overall response

  3. Curing America's Quick-Fix Mentality: A Role for Federally Supported Educational Research.

    Science.gov (United States)

    Florio, David H.

    1983-01-01

    Demands for immediate answers to education's problems affect federal support for needed long-term educational research programs. The National Institute of Education has made significant progress toward establishing valid research methods and a solid foundation for future research efforts, though restricted in its activities and denied due credit.…

  4. Federal role in resource recovery will focus on waste-to-energy R and D

    Energy Technology Data Exchange (ETDEWEB)

    Dawson, R.A.

    1981-05-01

    Virtually all of the federal programs created in recent years to sponsor resource recovery R and D have been slated for budget cuts or termination by the administration of President Ronald Reagan. The only programs that will survive revised fiscal budgets will be waste-to-energy R and D studies sponsored by DOE and EPA. Differing reactions to such cuts are apparent: the affected agencies are protesting, while private industry welcomes this hands-off policy.

  5. 78 FR 23885 - Federal Seed Act Program; Request for Extension and Revision of a Currently Approved Information...

    Science.gov (United States)

    2013-04-23

    ... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Doc. No. AMS-LS-13-0008] Federal Seed...: Agricultural Marketing Service, USDA. ACTION: Request for comments. SUMMARY: In accordance with the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35), this document announces the Agricultural Marketing Service's...

  6. The Role of Federal Government for Climate Adaptation in the Urban Context: Results of a workshop (Invited)

    Science.gov (United States)

    Buizer, J.; Chhetri, N.; Roy, M.

    2010-12-01

    network. Concerns included a broad range of issues, including flood protection, sea level rise, extreme events, infrastructure investment decisions, water supply, storm-water and wastewater management, public education and outreach. Suggestions included an in-depth exploration of new roles for federal agencies, as well as new partnerships with state and local entities, the private sector, and non-governmental entities; developing specialized communicators and trusted information brokers who can connect federal science agencies to local decision makers; and integrating federal decision making with local implementation.

  7. A Fiscal Cliff: The Current U.S. Federal Budget, Potential Cuts, and Impacts on Science Funding

    Science.gov (United States)

    Uhlenbrock, K. M.; Landau, E. A.; Hankin, E. R.

    2012-12-01

    As lawmakers on Capitol Hill face challenges to reach an agreement on how to cut the deficit while growing the economy, scientists must join the discussion and outline the serious impacts cuts to federal science programs will have on our society. Consistent and sustained federal science funding (discretionary spending) is an ever increasing struggle with the rising costs of mandatory spending and decrease in revenues. In 2011 Congress passed the Budget Control Act, which will require automatic across-the-board cuts, known as sequestration, and will take effect on 2 January 2013. Estimated cuts of $1.2 trillion and discretionary spending caps set at Fiscal Year 2012 levels will trigger non-defense program cuts of 9.8% in the first year as reported by the Congressional Research Service. Funding from non-defense program agencies such as NSF, NASA, DOE, NOAA, USGS, and others drive science and technological innovation, support public safety, create jobs, educate generations of scientists, stimulate the economy, protect our environment, and enrich lives. With non-defense discretionary programs representing less than one-fifth of the federal budget, severe cuts to these programs will not alleviate our deficit, but instead restrict our growth.

  8. [Points of view: the role of quality measurement from the Federal Joint Committee's perspective].

    Science.gov (United States)

    Klakow-Franck, Regina

    2014-01-01

    The Federal Joint Committee (G-BA) is a central decision-making body that issues binding directives to ensure the quality of both inpatient and outpatient health care services within the German Statutory Health Insurance system. Quality measurement on the basis of quality indicators has proceeded furthest in the field of external quality assurance (QA) of inpatient services. Originally designed for quality development in a "protected environment" through learning from better practices, it has been faced with new expectations since competitive elements have been introduced into the health care system. The economisation of medicine is de facto the driving force of the development of QA measures. In terms of health policy, the 2013 coalition agreement includes "a renaissance of the concept of quality competition". In particular, this is meant to strengthen the decision-making options of insured persons by creating more transparency into the quality of not only inpatient but also outpatient care and, if necessary, to support the possibility of selective agreements with individual health insurance funds. The campaign planned to improve the quality of hospitals also provides for a quality-oriented advancement of hospital planning and funding; and the Federal Joint Committee, supported by the new Institute for Quality Assurance and Transparency in the Healthcare System in accordance with Section 137a of Book V of the Social Code (SGB V) in the GKV-FQWG version will be assigned new tasks within this context, too. On the whole, the measures already agreed upon in the Act to Improve the Financial Structure and Quality of the Statutory Health Insurance System (GKV-FQWG) and—as far as can now be anticipated—the proceedings of the working group set up between the German government and the German federal states indicate that there is a high need to improve the methods and tools of external quality assurance available, starting with questions about the validity of the quality

  9. Role of disposal in developing Federal Facility Compliance Act mixed waste treatment plans

    International Nuclear Information System (INIS)

    Case, J.T.; Rhoderick, J.

    1994-01-01

    The Federal Facilities Compliance Act (FFCA) was enacted on October 6, 1992. This act amends the Solid Waste Disposal Act, which was previously amended by the Resource Conservation and Recovery Act (RCRA). The FFCA set in place a process for managing the Department of Energy's (DOE) mixed low-level radioactive wastes (MLLW), wastes that contain both hazardous and low-level radioactive constituents, with full participation of the affected states. The FFCA provides the framework for the development of treatment capacity for DOE's mixed waste. Disposal of the treatment residues is not addressed by the FFCA. DOE has initiated efforts in concert with the states in the development of a disposal strategy for the treated mixed wastes. This paper outlines DOE efforts in development of a mixed waste disposal strategy which is integrated with the FFCA Site Treatment Planning process

  10. Vaccines and Airline Travel: A Federal Role to Protect the Public Health.

    Science.gov (United States)

    Robertson, Christopher T

    2016-05-01

    This Article explores two ways in which airline travel is an important vector for the spread of infectious disease, and argues that airlines have market-based and liability-based reasons to require that passengers be vaccinated. Going further, the Article explores whether the federal government has the legal and constitutional authority-especially under the Commerce Clause-to encourage or mandate that airlines implement such a vaccine screen. By disrupting the spread of disease at key network nodes where individuals interact and then connect with other geographic regions, and by creating another incentive for adult vaccination, an airline vaccine screen could be an effective and legally viable tool for the protection of public health.

  11. Tidal residual current and its role in the mean flow on the Changjiang Bank

    Science.gov (United States)

    Xuan, Jiliang; Yang, Zhaoqing; Huang, Daji; Wang, Taiping; Zhou, Feng

    2016-02-01

    The tidal residual current may play an important role in the mean flow in the Changjiang Bank region, in addition to other residual currents, such as the Taiwan Warm Current, the Yellow Sea Coastal Current, and the Yellow Sea Warm Current. In this paper, a detailed structure of the tidal residual current, in particular the meso-scale eddies, in the Changjiang Bank region is observed from model simulations, and its role in the mean flow is quantified using the well-validated Finite Volume Coastal Ocean Model. The tidal residual current in the Changjiang Bank region consists of two components: an anticyclonic regional-scale tidal residual circulation around the edge of the Changjiang Bank and some cyclonic meso-scale tidal residual eddies across the Changjiang Bank. The meso-scale tidal residual eddies occur across the Changjiang Bank and contribute to the regional-scale tidal residual circulation offshore at the northwest boundary and on the northeast edge of the Changjiang Bank, southeastward along the 50 m isobath. Tidal rectification is the major mechanism causing the tidal residual current to flow along the isobaths. Both components of the tidal residual current have significant effects on the mean flow. A comparison between the tidal residual current and the mean flow indicates that the contribution of the tidal residual current to the mean flow is greater than 50%.

  12. Tidal residual current and its role in the mean flow on the Changjiang Bank

    Energy Technology Data Exchange (ETDEWEB)

    Xuan, Jiliang; Yang, Zhaoqing; Huang, Daji; Wang, Taiping; Zhou, Feng

    2016-02-01

    Tidal residual current may play an important role in the mean flow in the Changjiang Bank region, in addition to other residual currents, such as the Taiwan Warm Current, the Yellow Sea Coastal Current, and the Yellow Sea Warm Current. In this paper, a detailed structure of the tidal residual current, in particular the meso-scale eddies, in the Changjiang Bank region is observed from model simulations, and its role in the mean flow is quantified using the well-validated Finite Volume Coastal Ocean Model). The tidal residual current in the Changjiang Bank region consists of two components: an anticyclonic regional-scale tidal residual circulation around the edge of the Changjiang Bank and some cyclonic meso-scale tidal residual eddies across the Changjiang Bank. The meso-scale tidal residual eddies occur across the Changjiang Bank and contribute to the regional-scale tidal residual circulation offshore at the northwest boundary and at the northeast edge of the Changjiang Bank, southeastward along the 50 m isobath. Tidal rectification is the major mechanism causing the tidal residual current to flow along the isobaths. Both components of the tidal residual current have significant effects on the mean flow. A comparison between the tidal residual current and the mean flow indicates that the contribution of the tidal residual current to the mean flow is greater than 50%.

  13. Role of Airpower for Counterinsurgency in Afghanistan and FATA (Federally Administered Tribal Areas)

    Science.gov (United States)

    2009-06-01

    Malaysia , Greece, Philippine and Vietnam. The last part briefly analyzes the methods used to separate the population from insurgents and the role of...the Senate. These members were elected by the tribal maliks until 1997, when universal franchise was introduced in FATA. Under the Pakistan Political

  14. Public Support for Public Schools: The Past, the Future, and the Federal Role.

    Science.gov (United States)

    Piele, Philip K.

    1983-01-01

    Various indices of public support for the schools--school finance voting patterns, public opinion polls, and court litigation--are analyzed to document current trends. Two possible scenarios are forecast for the future, based on socioeconomic and demographic patterns. The need for future government support is stressed. (PP)

  15. Federated Identity Management

    OpenAIRE

    Chadwick, David W.

    2009-01-01

    Abstract. This paper addresses the topic of federated identity management. It discusses in detail the following topics: what is digital identity, what is identity management, what is federated identity management, Kim Camerons 7 Laws of Identity, how can we protect the users privacy in a federated environment, levels of assurance, some past and present federated identity management systems, and some current research in FIM.

  16. The Role and Place of State of Event-Strategic Megaobjects in the Sustainable Territorial Development of the Russian Federation

    Directory of Open Access Journals (Sweden)

    Vladimir Yuryevich Ivanov

    2016-12-01

    Full Text Available Russia is actively trying to raise its image and rating in the international political, sports and social spheres. This can be achieved by hosting major All-Russian and international events such as APEC 2012 summit, the 2013 Summer Universiade, the XXII Olympic Winter Games and XI Paralympic Winter Games 2014, FIFA 2018, 2019 Winter Universiade etc. We point to the absence of complex scientific approach to managing such event-strategic megaobjects, and this has negative affect on the Russian economy. The subject of the present research is represented by the role of state event-strategic megaobjects in sustainable regional development of Russia. The analysis allowed to identify a number of features of these objects, and to point out key issues and risks in their implementation. We consider the use of innovative crowdfunding technology to be the positive aspect of public megaobjects’ management. The negative aspects include the excessive scale of the financial costs and problems of cost-effective use of megaobjects after the hosting events. The territorial aspect of the analysis revealed the absence of a systemic approach to the selection of regions for hosting international events, as well as the unevenness of the territorial distribution of megaobjects. The largest event-strategic megaobjects were implemented in the Far Eastern Federal district (APEC summit in Vladivostok in 2012, the Southern Federal district (Krasnodar region, Sochi – The winter Olympic and Paralympic games in February 2014, Volga Federal district (the Universiade in Kazan in 2013. These districts did not become the leading regions in socio-economic development of Russia neither before nor after these events. The studies of such socio-economic and political phenomena will help to present theoretical and practical aspects of their application algorithm in the future for the purpose of balanced regional development of Russia.

  17. Physiological roles of the transient outward current Ito in normal and diseased hearts

    DEFF Research Database (Denmark)

    Cordeiro, Jonathan M.; Callø, Kirstine; Aschar-Sobbi, Roozbeh

    2016-01-01

    The Ca2+-independent transient outward K+ current (Ito) plays a critical role in underlying phase 1 of repolarization of the cardiac action potential and, as a result, is central to modulating excitation-contraction coupling and propensity for arrhythmia. Additionally, Ito and its molecular...... potential and the mechanisms by which Ito modulates excitation-contraction coupling. We also describe the effects of mutations in the subunits constituting the Ito channel as well as the role of Ito in the failing myocardium. Finally, we review pharmacological modulation of Ito and discuss the evidence...... constituents are consistently reduced in cardiac hypertrophy and heart failure. In this review, we discuss the physiological role of Ito as well as the molecular basis of this current in human and canine hearts, in which Ito has been thoroughly studied. In particular, we discuss the role of Ito in the action...

  18. On the role of neutral flow in field-aligned currents

    Science.gov (United States)

    Mannucci, Anthony J.; Verkhoglyadova, Olga P.; Meng, Xing; McGranaghan, Ryan

    2018-01-01

    In this brief note we explore the role of the neutral atmosphere in magnetosphere-ionosphere coupling. We analyze momentum balance in the ion rest frame to form hypotheses regarding the role of neutral momentum in the lower ionosphere during geomagnetic storms. Neutral momentum that appears in the ion rest frame is likely the result of momentum imparted to ionospheric ions by solar wind flow and the resultant magnetospheric dynamics. The resulting ion-neutral collisions lead to the existence of an electric field. Horizontal electron flow balances the momentum supplied by this electric field. We suggest a possible role played by the neutral atmosphere in generating field-aligned currents due to local auroral heating. Our physical interpretation suggests that thermospheric neutral dynamics plays a complementary role to the high-latitude field-aligned currents and electric fields resulting from magnetospheric dynamics.

  19. On the role of neutral flow in field-aligned currents

    Directory of Open Access Journals (Sweden)

    A. J. Mannucci

    2018-01-01

    Full Text Available In this brief note we explore the role of the neutral atmosphere in magnetosphere–ionosphere coupling. We analyze momentum balance in the ion rest frame to form hypotheses regarding the role of neutral momentum in the lower ionosphere during geomagnetic storms. Neutral momentum that appears in the ion rest frame is likely the result of momentum imparted to ionospheric ions by solar wind flow and the resultant magnetospheric dynamics. The resulting ion-neutral collisions lead to the existence of an electric field. Horizontal electron flow balances the momentum supplied by this electric field. We suggest a possible role played by the neutral atmosphere in generating field-aligned currents due to local auroral heating. Our physical interpretation suggests that thermospheric neutral dynamics plays a complementary role to the high-latitude field-aligned currents and electric fields resulting from magnetospheric dynamics.

  20. The current state of external quality control surveys in the German Federal Republic in the field of peptide hormone radioimmunoassays

    International Nuclear Information System (INIS)

    Marschner, I.; Scriba, P.C.; Wood, W.G.; Breuer, H.; Jungbluth, D.; Roehle, G.

    1977-01-01

    Two types of quality control surveys (QSC) are performed in the Federal Republic of Germany in the field of hormone assays: 1) The distribution of two lyophilized sera at regular intervals, in which the participants have to determine 7 or 8 different hormones. Because of the lack of reference methods for peptide hormones, the statistical evaluation of the results indicates only whether the results of the participants are 'correct' or contain systematic or nonsystematic errors with respect to the findings of the other participants. 2) The distribution of approximately 20 deep-frozen sera (including a standard curve in hormone-free serum) in which the participant has to assay a single hormone. These 20 sera-QCS are performed only at long intervals for a given hormone. The statistical analysis of the rate of the radioactive counts of the QCS-sera and those of the participants' standard curves allows - together with a methodological inquiry form - detection of probable causes for deviating results. (orig.) [de

  1. People’s Republic of China and Federal Republic of Germany in current international relations in Central Asia

    Directory of Open Access Journals (Sweden)

    A V Tsvyk

    2014-12-01

    Full Text Available This article is devoted to the analysis of the current Sino-German relations in the context of world politics and dynamics of international relations as exemplified by the Central Asia region. Basic problems and prospects for cooperation between China and Germany in this region, as well as possible ways of cooperation of the SCO and the EU are under consideration.

  2. Forget the Desk Job: Current Roles and Responsibilities in Entry-Level Reference Job Advertisements

    Science.gov (United States)

    Detmering, Robert; Sproles, Claudene

    2012-01-01

    This study examines the evolving roles and responsibilities of entry-level academic reference positions, as stated in recent job advertisements posted on the American Library Association's JobLIST Web site and other sources. Findings from a content analysis of these advertisements indicate that current entry-level reference positions in academic…

  3. Current and future role of echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy

    NARCIS (Netherlands)

    Mast, Thomas P.; Teske, Arco J.; Doevendans, Pieter A.; Cramer, Maarten J.

    Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited progressive cardiomyopathy, clinically characterized by ventricular arrhythmias and increased risk of sudden cardiac death. Echocardiography has a role in the diagnosis and prognosis of ARVD/C. However, in the current

  4. The current role of high-resolution ultrasonography of the hand and wrist in rheumatic diseases

    NARCIS (Netherlands)

    van Vugt, R. M.; van Dalen, A.; Bijlsma, J. W.

    1998-01-01

    To assess the current role of ultrasound in the diagnosis and treatment of pathological changes in the wrist and hand. 39 patients (14 male and 25 female, mean age 35 yrs.) with ill-defined pain and/or swelling of the wrist or hand were examined using a high-definition ultrasound (US) instrument. 18

  5. Federal Market Information Technology in the Post Flash Crash Era: Roles for Supercomputing

    Energy Technology Data Exchange (ETDEWEB)

    Bethel, E. Wes; Leinweber, David; Ruebel, Oliver; Wu, Kesheng

    2011-09-16

    This paper describes collaborative work between active traders, regulators, economists, and supercomputing researchers to replicate and extend investigations of the Flash Crash and other market anomalies in a National Laboratory HPC environment. Our work suggests that supercomputing tools and methods will be valuable to market regulators in achieving the goal of market safety, stability, and security. Research results using high frequency data and analytics are described, and directions for future development are discussed. Currently the key mechanism for preventing catastrophic market action are “circuit breakers.” We believe a more graduated approach, similar to the “yellow light” approach in motorsports to slow down traffic, might be a better way to achieve the same goal. To enable this objective, we study a number of indicators that could foresee hazards in market conditions and explore options to confirm such predictions. Our tests confirm that Volume Synchronized Probability of Informed Trading (VPIN) and a version of volume Herfindahl-Hirschman Index (HHI) for measuring market fragmentation can indeed give strong signals ahead of the Flash Crash event on May 6 2010. This is a preliminary step toward a full-fledged early-warning system for unusual market conditions.

  6. The role and importance of UAV within the current theaters of operations

    Directory of Open Access Journals (Sweden)

    Niculae MARIN

    2010-06-01

    Full Text Available Current theaters of operations are not limited to battlefields, but they are much morediversified, including the fight against the international terrorism phenomenon, the social conflicts (ofreligious, political, economic and separatist nature within several countries, thus supplying somepolitical-military conflicts within different states and areas of the world. The armed interference mustbe done based on some highly accurate information that must be gathered without endangering thehuman lives. This is the role currently played by the unmanned air vehicles (UAVs; they can performseveral functions: surveillance, information gathering, data storage and their transmission to theground stations, including the function of interference, when needed. This paper presents, within theabove context, the status of the current theaters of operations and of the UAVs performing differentmissions within these theaters, together with their role and importance in warfare operations.

  7. Symposium 19: Federal University of Rio Grande do Sul: its Role in the Biochemistry Teaching in the Southernmost Brazilian States

    Directory of Open Access Journals (Sweden)

    Clóvis M.D. Wannmacher

    2014-08-01

    Full Text Available K-Education(Portuguese Chair: V. Trindade Bayardo Torres; Clovis Wannmacher; Denise Macedo  Federal University of Rio Grande do Sul: its Role in the Biochemistry Teaching in the Southernmost Brazilian States. Wannmacher, C.M.D. Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.   At present, most Biochemistry teaching in Rio Grande do Sul and Santa Catarina has its origin in the Department of Biochemistry of the Federal University of Rio Grande do Sul. In the 70’s, all the teachers of the Department wrote a book together: “Fundamental Biochemistry”. This book was always used in the classes by groups of students of different careers supervised by the respective teacher. At the same time, this methodology was not used by pharmaceutical teachers, but they recommended the Department’s book to their students. Along the next years, Biochemistry teaching was adapted according to the professional course and to the teacher’s personal characteristics. Today, there are two extremes strategies again: one traditional for the most basic biochemistry student’s formation (including theoretical, laboratorial, seminars and informatics classes and the other, experimental-clinical, for physician’s formation (including seminars of molecular approach to the most prevalent diseases, mainly, those leading to failure of organs/systems and the interaction with patients from HCPA by the interpretation of their biochemical data. On the other hand, the Post Graduation Program, at first, emphasized biochemistry teaching in a traditional form, but gradually changed the emphasis to investigation, and most classes changed to scientific paper reports. To stimulate the teaching formation, two activities were offered to post-graduation students: Biochemistry Teaching Methodology and Teaching Practice in Biochemistry. These activities promote opportunity for the students to

  8. Current role of the USNRC safety research program in support of the regulatory process

    International Nuclear Information System (INIS)

    Levine, S.

    1979-01-01

    The current role of the USNRC's safety research program is shown. Some aspects of this role in the wake of the TMI accident are discused as well as some historical perspective on the development of USNRC's program, its relationship with the NRC mission, an overview of the program activities and some recent research results, and finally the impact of the TMI accident in clarifiying needs for expedited and new research activities, including the need for a greatly enhanced use of probabilistic analysis techniques to improve the coherence of its regulatory process. (author)

  9. Role of Ureaplasma Respiratory Tract Colonization in Bronchopulmonary Dysplasia Pathogenesis: Current Concepts and Update.

    Science.gov (United States)

    Viscardi, Rose Marie; Kallapur, Suhas G

    2015-12-01

    Respiratory tract colonization with the genital mycoplasma species Ureaplasma parvum and Ureaplasma urealyticum in preterm infants is a significant risk factor for bronchopulmonary dysplasia (BPD). Recent studies of the ureaplasmal genome, animal infection models, and human infants have provided a better understanding of specific virulence factors, pathogen-host interactions, and variability in genetic susceptibility that contribute to chronic infection, inflammation, and altered lung development. This review provides an update on the current evidence supporting a causal role of ureaplasma infection in BPD pathogenesis. The current status of antibiotic trials to prevent BPD in Ureaplasma-infected preterm infants is also reviewed. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Role of Ureaplasma Respiratory Tract Colonization in BPD Pathogenesis: Current Concepts and Update

    Science.gov (United States)

    Viscardi, Rose Marie; Kallapur, Suhas G.

    2015-01-01

    SYNOPSIS Respiratory tract colonization with the genital mycoplasma species Ureaplasma parvum and U. urealyticum in preterm infants is a significant risk factor for BPD. Recent studies of the ureaplasmal genome, animal infection models, and human infants have provided a better understanding of specific virulence factors, pathogen-host interactions, and variability in genetic susceptibility that contribute to chronic infection, inflammation, and altered lung development. This review will provide an update on the current evidence supporting a causal role of Ureaplasma infection in BPD pathogenesis. The current status of antibiotic trials to prevent BPD in Ureaplasma-infected preterm infants is also reviewed. PMID:26593075

  11. The Role Of The Media In The Political Culture Of Russia: The Current Situation

    OpenAIRE

    Анна Леонидовна Кочурова

    2014-01-01

    The article is devoted to the analysis of the characteristics and activities of mass media as an institution of political culture, which should be aimed at raising citizens' awareness and capacity objective to organize information exchange between Government and citizens. Considered social acuteness and urgency of this problem, the main functions of the MASS MEDIA, a trend increase in the role and impact of the MEDIA on the current political situation in Russia.

  12. Role of transverse-momentum currents in the optical Magnus effect in free space

    OpenAIRE

    Luo, Hailu; Wen, Shuangchun; Shu, Weixing; Fan, Dianyuan

    2010-01-01

    We establish a general vector field model to describe the role of transverse-momentum currents in the optical Magnus effect in free space. As an analogy of the mechanical Magnus effect, the circularly polarized wave packet in our model acts as the rotating ball, and its rotation direction depends on the polarization state. Based on this model, we demonstrate the existence of an optical polarization-dependent Magnus effect which is significantly different from the conventional optical Magnus e...

  13. Mother's Childrearing History and Current Parenting: Patterns of Association and the Moderating Role of Current Life Stress

    Science.gov (United States)

    Hill, Carri; Stein, Jennifer; Keenan, Kate; Wakschlag, Lauren S.

    2006-01-01

    This study examined the association between positive and negative aspects of childrearing history and current parenting and the moderating effect of current stress. Seventy mother-child dyads participated in this study. Mothers provided retrospective reports of childrearing histories and current reports of life stress. Parenting was assessed via…

  14. Role of tonic GABAergic currents during pre- and early postnatal rodent development

    Directory of Open Access Journals (Sweden)

    Werner eKilb

    2013-09-01

    Full Text Available In the last three decades it became evident that the GABAergic system plays an essential role for the development of the central nervous system, by influencing the proliferation of neuronal precursors, neuronal migration and differentiation, as well as by controlling early activity patterns and thus formation of neuronal networks. GABA controls neuronal development via depolarizing membrane responses upon activation of ionotropic GABA receptors. However, many of these effects occur before the onset of synaptic GABAergic activity and thus require the presence of extrasynaptic tonic currents in neuronal precursors and immature neurons. This review summarizes our current knowledge about the role of tonic GABAergic currents during early brain development. In this review we compare the temporal sequence of the expression and functional relevance of different GABA receptor subunits, GABA synthesizing enzymes and GABA transporters. We also refer to other possible endogenous agonists of GABAA receptors. In addition, we describe functional consequences mediated by the GABAergic system during early developmental periods and discuss current models about the origin of extrasynaptic GABA and/or other endogenous GABAergic agonists during early developmental states. Finally, we present evidence that tonic GABAergic activity is also critically involved in the generation of physiological as well as pathophysiological activity patterns before and after the establishment of functional GABAergic synaptic connections.

  15. Manual Therapy: The Historical, Current, and Future Role in the Treatment of Pain

    Directory of Open Access Journals (Sweden)

    A. Russell Smith

    2007-01-01

    Full Text Available Manual therapy has been an approach in the management of patients with various disorders dating back to ancient times and continues to play a significant role in current health care. The future role of manual therapy in health care is an important area of research. This paper reviews the history of manual therapy, examines the current literature related to the use of manual techniques (including manipulation, massage, and nerve manipulation, and discusses future research topics. The literature related to manual therapy has historically been anecdotal and theoretical, and current research tends to have a generic approach with broad definitions of manual therapy and inconsistencies in the classification of specific disorders. Systematic reviews of various types of manual therapy have differed on their conclusions regarding the effectiveness of this treatment modality. The current demand in health care for evidence-based practice necessitates a movement towards more specificity in the research of the effectiveness of manual therapy, with emphasis on specific patient signs and symptoms and specific manual techniques that result in effective care.

  16. Manual Therapy: The Historical, Current, and Future Role in the Treatment of Pain

    Science.gov (United States)

    Smith, A. Russell

    2007-01-01

    Manual therapy has been an approach in the management of patients with various disorders dating back to ancient times and continues to play a significant role in current health care. The future role of manual therapy in health care is an important area of research. This paper reviews the history of manual therapy, examines the current literature related to the use of manual techniques (including manipulation, massage, and nerve manipulation), and discusses future research topics. The literature related to manual therapy has historically been anecdotal and theoretical, and current research tends to have a generic approach with broad definitions of manual therapy and inconsistencies in the classification of specific disorders. Systematic reviews of various types of manual therapy have differed on their conclusions regarding the effectiveness of this treatment modality. The current demand in health care for evidence-based practice necessitates a movement towards more specificity in the research of the effectiveness of manual therapy, with emphasis on specific patient signs and symptoms and specific manual techniques that result in effective care. PMID:17334604

  17. [Is the structure of surgical clinics in Germany changing? A current investigation into the structure of surgical clinics in the Federal Republic of Germany].

    Science.gov (United States)

    Lob, G; Lob, T; Bauer, H; Niethard, F; Polonius, J; Siebert, H

    2009-04-01

    Medical developments have led to extensive specialization in the field of surgery. This has already been reflected for many years in altered structure and organization forms of surgical clinics. Indispensable quality standards, statutory general conditions, increasing competition in service providers and health insurance with transparency of the service procedure all intensify this trend. The aim of this investigation was, therefore, to determine how far this differentiation of service supply in the field of surgery is also reflected in the area and in surgical departments and clinics of basic and routine supply. To achieve this, all available published information on the structure and organization of surgical clinics in the Federal Republic of Germany was classified according to current departmentalization into "undivided" or general/visceral surgery facilities compared to orthopedic/trauma surgery departments.

  18. Electricity Transmission, Pipelines, and National Trails: An Analysis of Current and Potential Intersections on Federal Lands in the Eastern United States, Alaska, and Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Kuiper, James A. [Argonne National Lab. (ANL), Argonne, IL (United States); Krummel, John R. [Argonne National Lab. (ANL), Argonne, IL (United States); Hlava, Kevin J. [Argonne National Lab. (ANL), Argonne, IL (United States); Moore, H. Robert [Argonne National Lab. (ANL), Argonne, IL (United States); Orr, Andrew B. [Argonne National Lab. (ANL), Argonne, IL (United States); Schlueter, Scott O. [Argonne National Lab. (ANL), Argonne, IL (United States); Sullivan, Robert G. [Argonne National Lab. (ANL), Argonne, IL (United States); Zvolanek, Emily A. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-11-21

    As has been noted in many reports and publications, acquiring new or expanded rights-of-way for transmission is a challenging process, because numerous land use and land ownership constraints must be overcome to develop pathways suitable for energy transmission infrastructure. In the eastern U.S., more than twenty federally protected national trails (some of which are thousands of miles long, and cross many states) pose a potential obstacle to the development of new or expanded electricity transmission capacity. However, the scope of this potential problem is not well-documented, and there is no baseline information available that could allow all stakeholders to study routing scenarios that could mitigate impacts on national trails. This report, Electricity Transmission, Pipelines, and National Trails: An Analysis of Current and Potential Intersections on Federal Lands in the Eastern United States, was prepared by the Environmental Science Division of Argonne National Laboratory (Argonne). Argonne was tasked by DOE to analyze the “footprint” of the current network of National Historic and Scenic Trails and the electricity transmission system in the 37 eastern contiguous states, Alaska, and Hawaii; assess the extent to which national trails are affected by electrical transmission; and investigate the extent to which national trails and other sensitive land use types may be affected in the near future by planned transmission lines. Pipelines are secondary to transmission lines for analysis, but are also within the analysis scope in connection with the overall directives of Section 368 of the Energy Policy Act of 2005, and because of the potential for electrical transmission lines being collocated with pipelines.

  19. MRS [monitored retrievable storage] systems study Task G report: The role and functions of surface storage of radioactive material in the federal waste management system

    International Nuclear Information System (INIS)

    Wood, T.W.; Short, S.M.; Woodruff, M.G.; Altenhofen, M.K.; MacKay, C.A.

    1989-04-01

    This is one of nine studies undertaken by contractors to the US Department of Energy (DOE), Office of Civilian Radioactive Waste Management (OCRWM), to provide a technical basis for re-evaluating the role of a monitored retrievable storage (MRS) facility. The study investigates the functions that could be performed by surface storage of radioactive material within the federal radioactive waste management system, including enabling acceptance of spent fuel from utility owners, scheduling of waste-preparation processes within the system, enhancement of system operating reliability, and conditioning the thermal (decay heat) characteristics of spent fuel emplaced in a repository. The analysis focuses particularly on the effects of storage capacity and DOE acceptance schedule on power reactors. Figures of merit developed include the storage capacity [in metric tons of uranium (MTU)] required to be added beyond currently estimated maximum spent fuel storage capacities and its associated cost, and the number of years that spent fuel pools would remain open after last discharge (in pool-years) and the cost of this period of operation. 27 refs., 36 figs., 18 tabs

  20. Toward Institutional Autonomy or Nationalization? A Case Study of the Federal Role in U.S. Higher Education Accreditation

    Science.gov (United States)

    Matthews, Leah K.

    2012-01-01

    The centerpiece of the United States government's commitment to assuring that more Americans enroll in college and earn a degree is a massive system of federal financial aid that delivers billions of dollars to millions of students enrolled in accredited universities across the country. Since 1952, the federal government has relied upon…

  1. Exploring current and potential roles of Australian community pharmacists in gout management: a qualitative study.

    Science.gov (United States)

    Counsell, Allyce B; Nguyen, Amy D; Baysari, Melissa T; Kannangara, Diluk R W; McLachlan, Andrew J; Day, Richard O

    2018-05-09

    Gout is an increasingly prevalent form of inflammatory arthritis. Although effective treatments for gout exist, current management is suboptimal due to low medication adherence rates and treatments that are non-concordant with guidelines. Medications are the mainstay and most effective form of gout management. Thus, there is potential for community pharmacists to play an important primary health care role in gout management, however their current role and their potential to improve management of gout treatment is currently unclear. The purpose of the study is to explore the views of Australian pharmacists on their roles in gout management and to identify factors influencing their involvement in gout management. A convenience sample of community pharmacists were invited to participate using a snowballing recruitment strategy. Semi-structured, face-to-face interviews were conducted with 15 pharmacists of varying age, gender and pharmacy experience. Interviews focused on pharmacists' experiences of managing gout, interactions with people living with gout and their perceived roles and responsibilities in gout management. Interviews were transcribed verbatim and independently analysed by two reviewers to identify themes. The main role of pharmacists reported in gout management was providing patient education. The greatest facilitator to pharmacists involvement in gout management was identified to be pharmacists' good understanding of gout and its management. Barriers to pharmacists involvement were identified to be difficulties in monitoring adherence to gout medications, low priority given to gout in the pharmacy compared to other chronic health conditions, and lack of specific training and/or continuing education in gout prevention and management. Pharmacists can expand their primary health care role in gout management, particularly in the area of ongoing provision of education to people living with gout and in monitoring medication adherence in patients. However, a

  2. Vitamin E in Sarcopenia: Current Evidences on Its Role in Prevention and Treatment

    Directory of Open Access Journals (Sweden)

    Shy Cian Khor

    2014-01-01

    Full Text Available Sarcopenia is a geriatric syndrome that is characterized by gradual loss of muscle mass and strength with increasing age. Although the underlying mechanism is still unknown, the contribution of increased oxidative stress in advanced age has been recognized as one of the risk factors of sarcopenia. Thus, eliminating reactive oxygen species (ROS can be a strategy to combat sarcopenia. In this review, we discuss the potential role of vitamin E in the prevention and treatment of sarcopenia. Vitamin E is a lipid soluble vitamin, with potent antioxidant properties and current evidence suggesting a role in the modulation of signaling pathways. Previous studies have shown its possible beneficial effects on aging and age-related diseases. Although there are evidences suggesting an association between vitamin E and muscle health, they are still inconclusive compared to other more extensively studied chronic diseases such as neurodegenerative diseases and cardiovascular diseases. Therefore, we reviewed the role of vitamin E and its potential protective mechanisms on muscle health based on previous and current in vitro and in vivo studies.

  3. eHealth in Belgium, a new "secure" federal network: role of patients, health professions and social security services.

    Science.gov (United States)

    France, Francis Roger

    2011-02-01

    eHealth platform is the official federal network in Belgium (created by law on 21 August 2008) devoted to a secure exchange of health data in many types of applications, such as health care purposes, simplification of administrative procedures and contribution to health policy. It implies a controlled access to decentralized databases and uses encrypted personal data. The national identification number has been chosen in order to authenticate the requester, the patient, and the receiver of information exchange. Authorizations have to be respected in order to obtain personal health data. Several questions are raised about its security: the lack of mandatory request for systematic journaling on accesses to the electronic patient record as well as the absence of explicit procedures for sanctions in case of unauthorized access, the new role of social security administration in managing security where a eHealth manager can be both judge and party (in the function of trusted third party for health data encryption and of a required lawyer for texts proposed by physicians to the Commission for the protection of private life). Another critic concerns the number of physicians in minority and the absence of patients' delegates in the eHealth Board. At a time when the patient is becoming a partner in the care team, should not he be the gate-keeper for the access to his own health record? How could networks help him to get the appropriate knowledge to contribute to care and to write his testament of life? Recent laws (on private life, patient rights and euthanasia) have contributed to a behavioural change in citizens and physician attitudes. Recommendations are made in order to improve the acceptability of eHealth platform. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  4. Current status and emerging role of glutathione in food grade lactic acid bacteria

    Directory of Open Access Journals (Sweden)

    Pophaly Sarang

    2012-08-01

    Full Text Available Abstract Lactic acid bacteria (LAB have taken centre stage in perspectives of modern fermented food industry and probiotic based therapeutics. These bacteria encounter various stress conditions during industrial processing or in the gastrointestinal environment. Such conditions are overcome by complex molecular assemblies capable of synthesizing and/or metabolizing molecules that play a specific role in stress adaptation. Thiols are important class of molecules which contribute towards stress management in cell. Glutathione, a low molecular weight thiol antioxidant distributed widely in eukaryotes and Gram negative organisms, is present sporadically in Gram positive bacteria. However, new insights on its occurrence and role in the latter group are coming to light. Some LAB and closely related Gram positive organisms are proposed to possess glutathione synthesis and/or utilization machinery. Also, supplementation of glutathione in food grade LAB is gaining attention for its role in stress protection and as a nutrient and sulfur source. Owing to the immense benefits of glutathione, its release by probiotic bacteria could also find important applications in health improvement. This review presents our current understanding about the status of glutathione and its role as an exogenously added molecule in food grade LAB and closely related organisms.

  5. Electricity Transmission, Pipelines, and National Trails. An Analysis of Current and Potential Intersections on Federal Lands in the Eastern United States, Alaska, and Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Kuiper, James A; Krummel, John R; Hlava, Kevin J; Moore, H Robert; Orr, Andrew B; Schlueter, Scott O; Sullivan, Robert G; Zvolanek, Emily A

    2014-03-25

    As has been noted in many reports and publications, acquiring new or expanded rights-of-way for transmission is a challenging process, because numerous land use and land ownership constraints must be overcome to develop pathways suitable for energy transmission infrastructure. In the eastern U.S., more than twenty federally protected national trails (some of which are thousands of miles long, and cross many states) pose a potential obstacle to the development of new or expanded electricity transmission capacity. However, the scope of this potential problem is not well-documented, and there is no baseline information available that could allow all stakeholders to study routing scenarios that could mitigate impacts on national trails. This report, Electricity Transmission, Pipelines, and National Trails: An Analysis of Current and Potential Intersections on Federal Lands in the Eastern United States, was prepared by the Environmental Science Division of Argonne National Laboratory (Argonne). Argonne was tasked by DOE to analyze the “footprint” of the current network of National Historic and Scenic Trails and the electricity transmission system in the 37 eastern contiguous states, Alaska, and Hawaii; assess the extent to which national trails are affected by electrical transmission; and investigate the extent to which national trails and other sensitive land use types may be affected in the near future by planned transmission lines. Pipelines are secondary to transmission lines for analysis, but are also within the analysis scope in connection with the overall directives of Section 368 of the Energy Policy Act of 2005, and because of the potential for electrical transmission lines being collocated with pipelines. Based on Platts electrical transmission line data, a total of 101 existing intersections with national trails on federal land were found, and 20 proposed intersections. Transmission lines and pipelines are proposed in Alaska; however there are no

  6. Possible Role of Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder: Current Status

    International Nuclear Information System (INIS)

    Halepoto, D. M.; Bashir, S.; AL-Ayadhi, L.

    2014-01-01

    Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of survival-promoting molecules, plays a vital role in the growth, development, maintenance, and function of several neuronal systems. The purpose of this review is to document the support for the involvement of this molecule in the maintenance of normal cognitive, emotional functioning, and to outline recent developments in the content of Autism spectrum disorder (ASD). Current and future treatment development can be guided by developing understanding of this molecules actions in the brain and the ways the expression of BDNF can be planned. Over the years, research findings suggested a critical role played by BDNF in the development of autism including increased serum concentrations of BDNF in children with autism and identification of different forms of BDNF in families of autistic individuals. (author)

  7. Possible Role of Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder: Current Status

    Energy Technology Data Exchange (ETDEWEB)

    Halepoto, D. M.; Bashir, S.; AL-Ayadhi, L. [King Saud Univ., Riyadh (Saudi Arabia). Dept. of Physiology

    2014-04-15

    Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of survival-promoting molecules, plays a vital role in the growth, development, maintenance, and function of several neuronal systems. The purpose of this review is to document the support for the involvement of this molecule in the maintenance of normal cognitive, emotional functioning, and to outline recent developments in the content of Autism spectrum disorder (ASD). Current and future treatment development can be guided by developing understanding of this molecules actions in the brain and the ways the expression of BDNF can be planned. Over the years, research findings suggested a critical role played by BDNF in the development of autism including increased serum concentrations of BDNF in children with autism and identification of different forms of BDNF in families of autistic individuals. (author)

  8. A commentary on the current status and the future role of the European accident code

    International Nuclear Information System (INIS)

    Butland, A.T.D.

    1990-01-01

    This paper describes the history of the project to produce the European Accident code (EAC), leading to the planned release of a version of EAC-2 at the end of 1989. The requirements of a computer code to model the initiation phase of Hypothetical Core Disruptive Accidents (HCDAs) are discussed, paying particular attention to the lessons learnt in the CABRI project. The current status and content of the EAC-2 code are examined in relation to these requirements, noting how the sophisticated modelling plans for EAC-2 make it a benchmark code. The validation status of EAC-2 and future plans are discussed, noting that currently it consists solely of stand-alone validation of the modules used in EAC-2, rather than validation of the combined code. The future role of EAC-2 is briefly discussed in relation to the fast reactor plans in the EEC countries. (author)

  9. Temporary oil production, current account deterioration and the role of monetary and fiscal policy

    International Nuclear Information System (INIS)

    Harvie, C.

    1992-01-01

    This paper extends earlier work on the macroeconomic adjustment processes arising for an economy experiencing a temporary period of oil production. Emphasis is placed on developments in the current account, as reflected in foreign asset stock movements, after oil production ceases, as well as on the role that monetary, fiscal or fiscal/monetary policy can play in influencing current-account developments during this same period. The results presented suggest that, to improve the performance of the current account, irrespective of the wage adjustment mechanism operative, after oil production ceases, the major thrust of macroeconomic policy should operate through fiscal rather than monetary policy. However developments in non-oil output would be influenced by the wage adjustment mechanism. With wage indexation, a tight fiscal policy after oil production ceases leads to a higher level of non-oil output than in the no policy response case, or one where monetary policy alone is used. With no wage indexation, the use of monetary and/or fiscal policy leads to lower levels of non-oil output. The use of fiscal policy also has the added benefit of contributing to a lower consumer price level, again irrespective of the operative wage adjustment mechanism. If the emphasis of policy operates through monetary policy, irrespective of the wage adjustment mechanism, the current-account problem will be exacerbated since foreign assets stocks will be lower. In addition, non-oil output and consumer prices will be lower. (Author)

  10. Update on the slow delayed rectifier potassium current (I(Ks)): role in modulating cardiac function.

    Science.gov (United States)

    Liu, Zhenzhen; Du, Lupei; Li, Minyong

    2012-01-01

    The slow delayed rectifier current (I(Ks)) is the slow component of cardiac delayed rectifier current and is critical for the late phase repolarization of cardiac action potential. This current is also an important target for Sympathetic Nervous System (SNS) to regulate the cardiac electivity to accommodate to heart rate alterations in response to exercise or emotional stress and can be up-regulated by β- adrenergic or other signal molecules. I(Ks) channel is originated by the co-assembly of pore-forming KCNQ1 α-subunit and accessory KCNE1 β-subunit. Mutations in any subunit can bring about severe long QT syndrome (LQT-1, LQT-5) as characterized by deliquium, seizures and sudden death. This review summarizes the normal physiological functions and molecular basis of I(Ks) channels, as well as illustrates up-to-date development on its blockers and activators. Therefore, the current extensive survey should generate fundamental understanding of the role of I(Ks) channel in modulating cardiac function and donate some instructions to the progression of I(Ks) blockers and activators as potential antiarrhythmic agents or pharmacological tools to determine the physiological and pathological function of I(Ks).

  11. Role of transverse-momentum currents in the optical Magnus effect in free space

    International Nuclear Information System (INIS)

    Luo Hailu; Wen Shuangchun; Shu Weixing; Fan Dianyuan

    2010-01-01

    We establish a general vector field model to describe the role of transverse-momentum currents in the optical Magnus effect in free space. As an analogy of the mechanical Magnus effect, the circularly polarized wave packet in our model acts as the rotating ball, and its rotation direction depends on the polarization state. Based on this model, we demonstrate the existence of an optical polarization-dependent Magnus effect which is significantly different from the conventional optical Magnus effect in that light-matter interaction is not required. Further, we reveal the relation between transverse-momentum currents and the optical Magnus effect, and find that such a polarization-dependent rotation is unavoidable when the wave packet possesses transverse-momentum currents. The physics underlying this intriguing effect is the combined contributions of transverse spin and orbital currents. We predict that this effect may be observed experimentally even in the propagation direction. These findings provide further evidence for the optical Magnus effect in free space and can be extrapolated to other physical systems.

  12. ELMs and the role of current-driven instabilities in the edge

    International Nuclear Information System (INIS)

    Snyder, P.B.; Wilson, H.R.

    2001-01-01

    Edge localized modes (ELMs) can limit tokamak performance both directly, via large transient heat loads, and indirectly, through constraints placed on the H-mode pedestal height which impact global confinement. Theoretical understanding of the physics of ELMs should allow optimisation of existing experiments, and lead to greater confidence in projections for Next Step devices. However, understanding ELMs has proved challenging, in part because the sharp edge pressure gradients and consequent large bootstrap currents in the pedestal region provide drive for a variety of modes over a wide range of toroidal mode numbers (n). Here we present a brief discussion of ELM phenomenology, focussing primarily on ELMs whose frequency increases with input power. Theories of ELMs will be reviewed, emphasizing those which incorporate current-driven instabilities such as kink or 'peeling' modes. Parallel current plays a dual role in the edge, enhancing second stability access for ballooning modes while providing drive for peeling modes. The strong collisionality dependence of the edge bootstrap current introduces separate density and temperature dependence into pedestal MHD stability. We give a detailed description of recent work on coupled peeling-ballooning modes, including a model for ELM characteristics and temperature pedestal limits. Peeling-ballooning stability analysis of experimental discharges will be discussed, emphasising comparisons of different ELM regimes, such as the comparison between 'giant' and 'grassy' ELM shots on JT-60U. (orig.)

  13. Role of the lower hybrid spectrum in the current drive modeling for DEMO scenarios

    Science.gov (United States)

    Cardinali, A.; Castaldo, C.; Cesario, R.; Santini, F.; Amicucci, L.; Ceccuzzi, S.; Galli, A.; Mirizzi, F.; Napoli, F.; Panaccione, L.; Schettini, G.; Tuccillo, A. A.

    2017-07-01

    The active control of the radial current density profile is one of the major issues of thermonuclear fusion energy research based on magnetic confinement. The lower hybrid current drive could in principle be used as an efficient tool. However, previous understanding considered the electron temperature envisaged in a reactor at the plasma periphery too large to allow penetration of the coupled radio frequency (RF) power due to strong Landau damping. In this work, we present new numerical results based on quasilinear theory, showing that the injection of power spectra with different {n}// widths of the main lobe produce an RF-driven current density profile spanning most of the outer radial half of the plasma ({n}// is the refractive index in a parallel direction to the confinement magnetic field). Plasma kinetic profiles envisaged for the DEMO reactor are used as references. We demonstrate the robustness of the modeling results concerning the key role of the spectral width in determining the lower hybrid-driven current density profile. Scans of plasma parameters are extensively carried out with the aim of excluding the possibility that any artefact of the utilised numerical modeling would produce any novelty. We neglect here the parasitic effect of spectral broadening produced by linear scattering due to plasma density fluctuations, which mainly occurs for low magnetic field devices. This effect will be analyzed in other work that completes the report on the present breakthrough.

  14. Role of Ecological Cultural Synthesis in Enhancement of Importance and Competitive Ability of Polytechnic Education in the Southern Far East of the Russian Federation

    Science.gov (United States)

    Petukhov, V. I.; Golikov, S. Yu; Maiorov, I. S.

    2017-11-01

    The regional features of polytechnic education development under present-day conditions are considered. The enhanced role of ecological cultural synthesis is proved to be necessary in order to enhance the importance and competitive ability of the polytechnic education in the southern Far East of the Russian Federation. Ecological cultural synthesis is the major condition to turn natural management into the ecologically sparing management of natural resources; it is also a method of a person to learn nature and the mutual relations with nature. It should become a basis for educational programs in the higher schools of the Russian Federation (that may be used with the practical purposes not only in the Russian Federation), and it may promote the search of the national idea, ideological core, and basic principles of further education development in Russia.

  15. Health Information System Role-Based Access Control Current Security Trends and Challenges.

    Science.gov (United States)

    de Carvalho Junior, Marcelo Antonio; Bandiera-Paiva, Paulo

    2018-01-01

    This article objective is to highlight implementation characteristics, concerns, or limitations over role-based access control (RBAC) use on health information system (HIS) using industry-focused literature review of current publishing for that purpose. Based on the findings, assessment for indication of RBAC is obsolete considering HIS authorization control needs. We have selected articles related to our investigation theme "RBAC trends and limitations" in 4 different sources related to health informatics or to the engineering technical field. To do so, we have applied the following search query string: "Role-Based Access Control" OR "RBAC" AND "Health information System" OR "EHR" AND "Trends" OR "Challenges" OR "Security" OR "Authorization" OR "Attacks" OR "Permission Assignment" OR "Permission Relation" OR "Permission Mapping" OR "Constraint". We followed PRISMA applicable flow and general methodology used on software engineering for systematic review. 20 articles were selected after applying inclusion and exclusion criteria resulting contributions from 10 different countries. 17 articles advocate RBAC adaptations. The main security trends and limitations mapped were related to emergency access, grant delegation, and interdomain access control. Several publishing proposed RBAC adaptations and enhancements in order to cope current HIS use characteristics. Most of the existent RBAC studies are not related to health informatics industry though. There is no clear indication of RBAC obsolescence for HIS use.

  16. Noninvasive imaging of coronary arteries: current and future role of multidetector row computer tomography

    International Nuclear Information System (INIS)

    Nedevska, M.; Stoinova, V.

    2006-01-01

    Full text: This review will present the current and future role of cardiac computer tomography (CCT), and particular multidetector CCT, for imaging of atherosclerotic pathologic changes of the coronary arteries. Atherosclerosis and its cardio-vascular complications represent one of the major issues of public health in industrial countries. Different imaging modalities, including invasive coronarography, have been aimed to the diagnosis of the disease, when it provokes symptomatic decrease of the blood flow. In spite of development of surgical and percutaneous methods for coronary revascularization, coronary artery disease remains the major cause of death in North America and Europe. This demonstrates the need of novel, complementary diagnostic strategies, aimed to identify asymptomatic stages as the basis of pharmacological interventions. Noninvasive coronary angiography with multidetector CT allows both assessment of luminal stenosis and subclinical disease of arterial wall. Large trails are missing now to understand and present what will be the role of this technology in the comprehensive assessment of patients, suspected of having CAD. Based on experience and current potentials we will describe how tomographic coronary imaging may eventually supplement traditional angiographic techniques in understanding the patterns of atherosclerotic CAD development

  17. Russian Federation

    International Nuclear Information System (INIS)

    2001-01-01

    In the Russian Federation (RF), management of radioactive wastes will be carried out within the framework of the Federal Target Program for management of radioactive wastes and used nuclear materials for the period 1996-2005. The agency within the RF responsible for this program is the Ministry of Russian Federation on Atomic Energy. Current radioactive waste disposal activities are focused on creating regional repositories for wastes generated by radiochemical production, nuclear reactors, science centers, and from other sources outside of the nuclear-fuel cycle (the latter wastes are managed by Scientific and Industrial Association, 'RADON'). Wastes of these types are in temporary storage, with the exception of non-fuel cycle wastes which are in long term storage managed by SAI 'RADON'. The criteria for segregating between underground or near-surface disposal of radioactive waste are based on the radiation fields and radionuclide composition of the wastes. The most progress in creating regional repositories has been made in the Northwest region of Russia. However, development of a detailed design has begun for a test facility in the Northeast for disposal of radioactive wastes generated in Murmansk and Arkhangelsk provinces. The feasibility study for construction of this facility is being evaluated by state monitoring organizations, the heads of administrations of the Arkhangelsk and Murmansk provinces, and Minatom of Russia

  18. The role of ring current O+ in the formation of stable auroral red arcs

    International Nuclear Information System (INIS)

    Kozyra, J.U.; Cravens, T.E.; Nagy, A.F.; Shelley, E.G.; Comfort, R.H.; Brace, L.H.

    1987-01-01

    Coulomb collisions between ring current protons and thermal electrons were first proposed by Cole (1965) as the energy source for stable auroral red (SAR) arcs. Recent observations have shown that the ring current and magnetospheric plasma contain significant amounts of heavy ions (Johnson et al., 1977; Young et al., 1977; Geiss et al., 1978; and others). In fact, the ring current is often dominated by heavy ions at those energies (E ≤ 17 keV) important for Coulomb collisions on SAR arc field lines (Kozyra et al., 1986a). Observations (during four SAR arcs in 1981) of thermal and energetic ion populations by the Dynamics Explorer 1 satellite in the magnetospheric energy source region and nearly simultaneous Langmuir probe measurements of enhanced electron temperatures by Dynamics Explorer 2 within the SAR arc at F region heights have allowed the authors to examine the role of heavy ions in the formation of SAR arcs. They find that (1) sufficient energy is transferred to the electron gas at high altitudes via Coulomb collisions between the observed ring current ions and thermal electrons to support the enhanced (SAR arc) F region electron temperatures measured on these field lines, (2) the latitudinal variation in the electron heating rates calculated using observed ion populations is consistent with the observed variation in electron temperature across the SAR arc, and (3) in all cases, ring current O + is the major source of energy for the SAR arcs. This implies a relationship between the heavy ion content of the magnetospheric plasma and the occurrence frequency and intensity of SAR arcs

  19. Role of Nrf2 in preventing oxidative stress induced chloride current alteration in human lung cells.

    Science.gov (United States)

    Canella, Rita; Benedusi, Mascia; Martini, Marta; Cervellati, Franco; Cavicchio, Carlotta; Valacchi, Giuseppe

    2018-08-01

    The lung tissue is one of the main targets of oxidative stress due to external sources and respiratory activity. In our previous work, we have demonstrated in that O 3 exposure alters the Cl - current-voltage relationship, with the appearance of a large outward rectifier component mainly sustained by outward rectifier chloride channels (ORCCs) in human lung epithelial cells (A549 line). In the present study, we have performed patch clamp experiments, in order to identify which one of the O 3 byproducts (4hydroxynonenal (HNE) and/or H 2 O 2 ) was responsible for chloride current change. While 4HNE exposition (up to 25 μM for 30' before electrophysiological analysis) did not reproduce O 3 effect, H 2 O 2 produced by glucose oxidase 10 mU for 24 hr before electrophysiological analysis mimicked O 3 response. This result was confirmed treating the cell with catalase (CAT) before O 3 exposure (1,000 U/ml for 2 hr): CAT was able to rescue Cl - current alteration. Since CAT is regulated by Nrf2 transcription factor, we pre-treated the cells with the Nrf2 activators, resveratrol and tBHQ. Immunochemical and immunocytochemical results showed Nrf2 activation with both substances that lead to prevent OS effect on Cl - current. These data bring new insights into the mechanisms involved in OS-induced lung tissue damage, pointing out the role of H 2 O 2 in chloride current alteration and the ability of Nfr2 activation in preventing this effect. © 2017 Wiley Periodicals, Inc.

  20. Role of oral zinc supplementation for reduction of neonatal hyperbilirubinemia: a systematic review of current evidence.

    Science.gov (United States)

    Sharma, Deepak; Farahbakhsh, Nazanin; Sharma, Pradeep; Shastri, Sweta

    2017-08-01

    Neonatal hyperbilirubinemia is frequently seen condition in the NICU. Oral zinc has been tried for the prevention of hyperbilirubinemia. To evaluate the role of oral zinc supplementation for reduction of neonatal hyperbilirubinemia in term and preterm infants. The literature search was done for various randomized control trial (RCT) by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, Scopus, Index Copernicus, African Index Medicus (AIM), Thomson Reuters (ESCI), Chemical Abstracts Service (CAS) and other data base. This review included six RCT that fulfilled inclusion criteria. One study evaluated the role of zinc in very low birth weight (VLBW) infants and remaining enrolled neonates  ≥35 weeks of gestation. The dose of zinc varied from 5 to 20 mg/day and duration from 5-7 days. All the studies used zinc sulfate, only one study used zinc gluconate. The total neonates enrolled in these different RCT are 749. Role of zinc in the prevention of neonatal hyperbilirubinemia is not supported by the current evidence. Only one study was able to show reduction in the mean TSB level and requirement of phototherapy with zinc, and the remaining studies did not report any positive effect. None of the studies showed any effect on the duration of phototherapy, incidence of phototherapy, age of starting of phototherapy and any serious adverse effect.

  1. Federal Holidays

    Data.gov (United States)

    Office of Personnel Management — Federal law (5 U.S.C. 6103) establishes the following public holidays for Federal employees. Please note that most Federal employees work on a Monday through Friday...

  2. Instabilities of collisionless current sheets revisited: The role of anisotropic heating

    International Nuclear Information System (INIS)

    Muñoz, P. A.; Kilian, P.; Büchner, J.

    2014-01-01

    In this work, we investigate the influence of the anisotropic heating on the spontaneous instability and evolution of thin Harris-type collisionless current sheets, embedded in antiparallel magnetic fields. In particular, we explore the influence of the macroparticle shape-function using a 2D version of the PIC code ACRONYM. We also investigate the role of the numerical collisionality due to the finite number of macroparticles in PIC codes. It is shown that it is appropriate to choose higher order shape functions of the macroparticles compared to a larger number of macroparticles per cell. This allows to estimate better the anisotropic electron heating due to the collisions of macroparticles in a PIC code. Temperature anisotropies can stabilize the tearing mode instability and trigger additional current sheet instabilities. We found a good agreement between the analytically derived threshold for the stabilization of the anisotropic tearing mode and other instabilities, either spontaneously developing or initially triggered ones. Numerical effects causing anisotropic heating at electron time scales become especially important for higher mass ratios (above m i /m e =180). If numerical effects are carefully taken into account, one can recover the theoretical estimated linear growth rates of the tearing instability of thin isotropic collisionless current sheets, also for higher mass ratios

  3. The effects of gender role orientation on team schema: a multivariate analysis of indicators in a US Federal health care organization.

    Science.gov (United States)

    Scherer, R F; Petrick, J A

    2001-02-01

    In this empirical study of 649 employees at a federally supported health care facility in the United States, the authors investigated the effects of individual gender role orientation on team schema. The results indicated (a) that nontraditional male and female employees perceived the greatest amount of group cohesion in their team schemas and (b) that both traditional and nontraditional male employees perceived greater problem-solving potential in their team schemas. Meaningful implications for team composition are discussed.

  4. New directions in federal energy management

    International Nuclear Information System (INIS)

    Ginsberg, M.

    1993-01-01

    The fuel embargo of 1973, followed by the oil disruption of 1979 heightened national security concerns over the availability and price of foreign oil to sustain all sectors of the U.S. economy. As a result of our growing dependence on foreign oil and diminishing resources at home, the Federal government has worked since 1974 to identify and implement a variety of measures to reduce energy consumption in Federal buildings and operations. Federal energy expenditures peaked at almost $14 billion in 1982 but has now been reduced to approximately $10 billion a year. However, much more needs to be done. Since the 1973 oil embargo, a series of legislative initiatives and Presidential authorities established the Federal Energy Management Program (FEMP) and then expanded it to address a broad range of energy-related issues affecting the Federal sector. Administered by the U.S. Department of Energy, FEMP coordinates the design and implementation of energy-saving programs for Federal buildings and operations. This includes working with other Federal agencies through interagency committees to interpret and implement Federal policy, to provide technical assistance to other Federal agencies, and to collect and report Federal energy consumption data to Congress. In addition, with the passage of the Clean Air Act Amendments of 1990, concerns over global climate change and a range of man-made and natural pollutants, environmental issues now play a critical role in our nation's energy policy. As a major consumer of energy, the Federal sector can serve as an important model for other sectors of the economy as a result of some of the innovative and cost-effective measures planned or currently underway. My talk today will focus on the Federal government's plans to ensure the energy efficient design and operation of Federal facilities, with an emphasis on life-cycle cost analyses

  5. The impact of Federal rehabilitation laws on the expanding role of employee assistance programs in business and industry.

    Science.gov (United States)

    Farkas, G M

    1989-12-01

    Federal statutory and case law protecting the rights of individuals with disabilities has had a major impact in expanding the occupational options for mentally and physically impaired employees. One serendipitous result of these protections has been the expansion of job opportunities for psychologists in business and industry. This article examines important federal laws and regulations pertaining to the employment rights of the handicapped worker and emphasizes the intricacies involved for psychologists who work in the employee assistance field or who consult with management. The expansion of vocational options for psychologists working with business is traced, and future prospects for psychologists in this area are explored.

  6. Current role of multidetector computed tomography in imaging of wrist injuries.

    Science.gov (United States)

    Syed, Mohd Arif; Raj, Vimal; Jeyapalan, Kanagaratnam

    2013-01-01

    Imaging of the wrist is challenging to both radiologists and orthopedic surgeons. This is primarily because of the complex anatomy/functionality of the wrist and also the fact that many frequent injuries are sustained to the hands. On going developments in multidetector computed tomography (MDCT) technology with its "state of the art" postprocessing capabilities have revolutionized this field. Apart from routine imaging of wrist trauma, it is now possible to assess intrinsic ligaments with MDCT arthrography, thereby avoiding invasive diagnostic arthroscopies. Postoperative wrist imaging can be a diagnostic challenge, and MDCT can be helpful in assessment of these cases because volume acquisition and excellent postprocessing abilities help to evaluate these wrists in any desired plane and thinner slices. This article pictorially reviews the current clinical role of MDCT imaging of wrist in our practice. It also describes arthrography technique and scanning parameters used at our center. Copyright © 2013 Mosby, Inc. All rights reserved.

  7. Roles of sunlight and natural ventilation for controlling infection: historical and current perspectives.

    Science.gov (United States)

    Hobday, R A; Dancer, S J

    2013-08-01

    Infections caught in buildings are a major global cause of sickness and mortality. Understanding how infections spread is pivotal to public health yet current knowledge of indoor transmission remains poor. To review the roles of natural ventilation and sunlight for controlling infection within healthcare environments. Comprehensive literature search was performed, using electronic and library databases to retrieve English language papers combining infection; risk; pathogen; and mention of ventilation; fresh air; and sunlight. Foreign language articles with English translation were included, with no limit imposed on publication date. In the past, hospitals were designed with south-facing glazing, cross-ventilation and high ceilings because fresh air and sunlight were thought to reduce infection risk. Historical and recent studies suggest that natural ventilation offers protection from transmission of airborne pathogens. Particle size, dispersal characteristics and transmission risk require more work to justify infection control practices concerning airborne pathogens. Sunlight boosts resistance to infection, with older studies suggesting potential roles for surface decontamination. Current knowledge of indoor transmission of pathogens is inadequate, partly due to lack of agreed definitions for particle types and mechanisms of spread. There is recent evidence to support historical data on the effects of natural ventilation but virtually none for sunlight. Modern practice of designing healthcare buildings for comfort favours pathogen persistence. As the number of effective antimicrobial agents declines, further work is required to clarify absolute risks from airborne pathogens along with any potential benefits from additional fresh air and sunlight. Copyright © 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  8. Anaesthetic specialist registrars in Ireland: current teaching practices and perceptions of their role as undergraduate teachers.

    LENUS (Irish Health Repository)

    Walsh, K

    2012-02-03

    BACKGROUND AND OBJECTIVES: Teaching is an important responsibility of non-consultant hospital doctors. In Ireland, specialist registrars (SpRs) in anaesthesia are contractually obliged to teach medical students, other doctors and nurses. Both medical students and fellow non-consultant hospital doctors attribute between 30 and 40% of their knowledge gain to non-consultant hospital doctors. METHODS: We carried out a confidential telephone survey of anaesthetic SpRs in Ireland regarding their current teaching practices and the perceptions of their role as undergraduate teachers. All the SpRs currently working in clinical practice in Ireland were eligible. RESULTS: Fifty-five of the 79 (70%) SpRs responded to the questionnaire. Only 7 (12.7%) of the respondents said they had been well trained as a teacher. The majority of the respondents stated that they would attend a learning-to-teach course\\/workshop if one was available, and felt that such a course would improve their ability as a teacher. Only 8 (14.5%) agreed that adequate emphasis is placed on commitment to teaching in the assessment of SpRs, both by individual departments and by the College of Anaesthetists. Anaesthetic SpRs in Ireland spend a considerable amount of time each day teaching undergraduate medical students, the majority (68.9%) stated that they had inadequate time to prepare for teaching. CONCLUSION: The majority of the respondents stated that they enjoy teaching, feel that they play an important role in undergraduate teaching but have inadequate time to prepare for teaching. An adequate emphasis is not placed on their commitment to teaching.

  9. Addressing current and future challenges for the NHS: the role of good leadership.

    Science.gov (United States)

    Elton, Lotte

    2016-10-03

    Purpose This paper aims to describe and analyse some of the ways in which good leadership can enable those working within the National Health Service (NHS) to weather the changes and difficulties likely to arise in the coming years, and takes the format of an essay written by the prize-winner of the Faculty of Medical Leadership and Management's Student Prize. The Faculty of Medical Leadership and Management ran its inaugural Student Prize in 2015-2016, which aimed at medical students with an interest in medical leadership. In running the Prize, the Faculty hoped to foster an enthusiasm for and understanding of the importance of leadership in medicine. Design/methodology/approach The Faculty asked entrants to discuss the role of good leadership in addressing the current and future challenges faced by the NHS, making reference to the Leadership and Management Standards for Medical Professionals published by the Faculty in 2015. These standards were intended to help guide current and future leaders and were grouped into three categories, namely, self, team and corporate responsibility. Findings This paper highlights the political nature of health care in the UK and the increasing impetus on medical professionals to navigate debates on austerity measures and health-care costs, particularly given the projected deficit in NHS funding. It stresses the importance of building organisational cultures prizing transparency to prevent future breaches in standards of care and the value of patient-centred approaches in improving satisfaction for both patients and staff. Identification of opportunities for collaboration and partnership is emphasised as crucial to assuage the burden that lack of appropriate social care places on clinical services. Originality/value This paper offers a novel perspective - that of a medical student - on the complex issues faced by the NHS over the coming years and utilises a well-regarded set of standards in conceptualising the role that health

  10. Role of turbulence fluctuations on uncertainties of acoutic Doppler current profiler discharge measurements

    Science.gov (United States)

    Tarrab, Leticia; Garcia, Carlos M.; Cantero, Mariano I.; Oberg, Kevin

    2012-01-01

    This work presents a systematic analysis quantifying the role of the presence of turbulence fluctuations on uncertainties (random errors) of acoustic Doppler current profiler (ADCP) discharge measurements from moving platforms. Data sets of three-dimensional flow velocities with high temporal and spatial resolution were generated from direct numerical simulation (DNS) of turbulent open channel flow. Dimensionless functions relating parameters quantifying the uncertainty in discharge measurements due to flow turbulence (relative variance and relative maximum random error) to sampling configuration were developed from the DNS simulations and then validated with field-scale discharge measurements. The validated functions were used to evaluate the role of the presence of flow turbulence fluctuations on uncertainties in ADCP discharge measurements. The results of this work indicate that random errors due to the flow turbulence are significant when: (a) a low number of transects is used for a discharge measurement, and (b) measurements are made in shallow rivers using high boat velocity (short time for the boat to cross a flow turbulence structure).

  11. Current roles of specific bacteria in the pathogenesis of inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Lucy McMullen

    2015-12-01

    Full Text Available The relevance of alterations in gut microbiota in the pathogenesis of inflammatory bowel disease (IBD remains unclear. Currently there is conflicting evidence with regards to the roles of specific bacterial species. Escherichia coli (particularly the adherent invasive strain are more prevalent in those with IBD and are associated with higher risk of IBD. However, the organisms are also present in healthy individuals and colonisation does not correlate with the degree of inflammation in IBD. Campylobacter concisus is more prevalent in those with IBD and higher levels of C. concisus specific IgG antibodies are found in the serum of those with IBD compared to healthy controls. Further, C. concisus has immunogenic properties that stimulate an antibody response suggesting the bacteria might trigger or exacerbate disease. Conversely most mycobacteria are unlikely to be causative as they are not presentin microbial stool cultures early in disease. In various studies,Mycobacterium aviumparatuberculosishas been detected both more frequently and not at all in individuals with Crohn's disease. Similar conflict exists with respect to Yersinia enterocolitica,Bacteroidesvulgatus and Helicobacter hepaticus, which are also more prevalent in IBD. However, these organisms appear more likely to contribute to disease persistence than initial disease development. This review aims to summarise the current understanding of key bacterial species implicated in the pathogenesis of IBD.

  12. Role of an inward rectifier K+ current and of hyperpolarization in human myoblast fusion

    Science.gov (United States)

    Liu, J-H; Bijlenga, P; Fischer-Lougheed, J; Occhiodoro, T; Kaelin, A; Bader, C R; Bernheim, L

    1998-01-01

    The role of K+ channels and membrane potential in myoblast fusion was evaluated by examining resting membrane potential and timing of expression of K+ currents at three stages of differentiation of human myogenic cells: undifferentiated myoblasts, fusion-competent myoblasts (FCMBs), and freshly formed myotubes. Two K+ currents contribute to a hyperpolarization of myoblasts prior to fusion: IK(NI), a non-inactivating delayed rectifier, and IK(IR), an inward rectifier. IK(NI) density is low in undifferentiated myoblasts, increases in FCMBs and declines in myotubes. On the other hand, IK(IR) is expressed in 28 % of the FCMBs and in all myotubes. IK(IR) is reversibly blocked by Ba2+ or Cs+. Cells expressing IK(IR) have resting membrane potentials of −65 mV. A block by Ba2+ or Cs+ induces a depolarization to a voltage determined by IK(NI) (−32 mV). Cs+ and Ba2+ ions reduce myoblast fusion. It is hypothesized that the IK(IR)-mediated hyperpolarization allows FCMBs to recruit Na+, K+ and T-type Ca2+ channels which are present in these cells and would otherwise be inactivated. FCMBs, rendered thereby capable of firing action potentials, could amplify depolarizing signals and may accelerate fusion. PMID:9705997

  13. Sport psychological associations role to create growth and stimulate networking in sports, federations and academia - experiences from Sweden and Denmark

    DEFF Research Database (Denmark)

    Becker-Larsen, Astrid; Edvardsson, Arne

    skills. Much has happened over the past 25 years since the Danish Society of Sport Psychology (DIFO;1992) and the Swedish Sports Psychological Association (SIPF; 2000) founded. When talking to experts in the field and looking at what is reported in media there have been a significant growing interest...... and networkning in sports, federations and academia. Metod/Method Board members from DIFO and SIPF have been invited to participate in this symposium. To initate discussion the participants have been given the assignment to answer the 3 open questions regarding their association: “What have you done in the past...... of SIPF or DIFO. The association’s goals are to promote and develop sports psychology research, teaching and applied practice by gathering experiences from different practitioners (e.g., academia, federations and sports). Therfore, it is in both assocations intrest to come togheter and discuss the past...

  14. Excipients and their role in approved injectable products: current usage and future directions.

    Science.gov (United States)

    Nema, Sandeep; Brendel, Ronald J

    2011-01-01

    This review article is a current survey of excipients used in approved injectable products. Information provided includes concentration ranges, function, frequency of use, and role in dosage form. This article is an update of a paper published more than a decade ago (reference 11). Since then many new products have been approved. Safety concerning excipients has evolved as the scientific community continues to learn about their usage. New excipients are being used in early phases of clinical trials to support novel therapeutic entities like RNAi, aptamers, anti-sense, fusion proteins, monoclonal antibodies, and variant scaffolds. Because these excipients are not inert, various pharmacopoeias are responding with monographs or informational chapters addressing excipient functionality. The final sections of this article discuss new excipients, serving specific needs that traditional excipients are unable to provide and for which safety studies are necessary to support a novel excipient for marketing applications. Excipients are added to parenteral dosage forms to serve a variety of functions including stabilization and as vehicles. This review article is a survey of excipients used in approved injectable products. Information provided includes excipient concentrations, functional roles, and frequency of use. This article is an update of an article originally published over a decade ago. Since then new products have been approved and safety concerns have evolved as the scientific community has learned about the usage of excipients. In addition, new excipients are being used in early phases of clinical trials to support novel therapeutic entities such as RNAi, aptamers, anti-sense, fusion proteins, monoclonal antibodies, and variant scaffolds. Because these excipients are not inert, various pharmacopoeias are responding with monographs or informational chapters addressing excipient functionality. The final sections of this article discuss new excipients, serving

  15. The Role of Soil Microorganisms in Plant Mineral Nutrition—Current Knowledge and Future Directions

    Science.gov (United States)

    Jacoby, Richard; Peukert, Manuela; Succurro, Antonella; Koprivova, Anna; Kopriva, Stanislav

    2017-01-01

    In their natural environment, plants are part of a rich ecosystem including numerous and diverse microorganisms in the soil. It has been long recognized that some of these microbes, such as mycorrhizal fungi or nitrogen fixing symbiotic bacteria, play important roles in plant performance by improving mineral nutrition. However, the full range of microbes associated with plants and their potential to replace synthetic agricultural inputs has only recently started to be uncovered. In the last few years, a great progress has been made in the knowledge on composition of rhizospheric microbiomes and their dynamics. There is clear evidence that plants shape microbiome structures, most probably by root exudates, and also that bacteria have developed various adaptations to thrive in the rhizospheric niche. The mechanisms of these interactions and the processes driving the alterations in microbiomes are, however, largely unknown. In this review, we focus on the interaction of plants and root associated bacteria enhancing plant mineral nutrition, summarizing the current knowledge in several research fields that can converge to improve our understanding of the molecular mechanisms underpinning this phenomenon. PMID:28974956

  16. The Current Role of Omega-3 Fatty Acids in the Management of Atrial Fibrillation

    Directory of Open Access Journals (Sweden)

    Georgios A. Christou

    2015-09-01

    Full Text Available Background: The main dietary source of omega-3 polyunsaturated fatty acids (n-3 PUFA is fish, which contains eicosapentaenoic acid (EPA and docosahexaenoic acid (DHA. In the present manuscript, we aimed to review the current evidence regarding the clinical role of n-3 PUFA in the prevention of atrial fibrillation (AF and the possible underlying mechanisms. Methods: A literature search based on PubMed listings was performed using “Omega-3 fatty acids” and “atrial fibrilation” as key search terms. Results: n-3 PUFA have been shown to attenuate structural atrial remodeling, prolong atrial effective refractory period through the prevention of reentry and suppress ectopic firing from pulmonary veins. Dietary fish intake has been found to have no effect on the incidence of AF in the majority of studies. Circulating DHA has been consistently reported to be inversely associated with AF risk, whereas EPA has no such effect. The majority of studies investigating the impact of n-3 PUFA supplementation on the incidence of AF following cardiac surgery reported no benefit, though most of them did not use n-3 PUFA pretreatment for adequate duration. Studies using adequate four-week pretreatment with n-3 PUFA before cardioversion of AF showed a reduction of the AF incidence. Conclusions: Although n-3 PUFA have antiarrhythmogenic properties, their clinical efficacy on the prevention of AF is not consistently supported. Further well-designed studies are needed to overcome the limitations of the existing studies and provide robust conclusions.

  17. The Current Role of Omega-3 Fatty Acids in the Management of Atrial Fibrillation.

    Science.gov (United States)

    Christou, Georgios A; Christou, Konstantinos A; Korantzopoulos, Panagiotis; Rizos, Evangelos C; Nikas, Dimitrios N; Goudevenos, John A

    2015-09-22

    The main dietary source of omega-3 polyunsaturated fatty acids (n-3 PUFA) is fish, which contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In the present manuscript, we aimed to review the current evidence regarding the clinical role of n-3 PUFA in the prevention of atrial fibrillation (AF) and the possible underlying mechanisms. A literature search based on PubMed listings was performed using "Omega-3 fatty acids" and "atrial fibrilation" as key search terms. n-3 PUFA have been shown to attenuate structural atrial remodeling, prolong atrial effective refractory period through the prevention of reentry and suppress ectopic firing from pulmonary veins. Dietary fish intake has been found to have no effect on the incidence of AF in the majority of studies. Circulating DHA has been consistently reported to be inversely associated with AF risk, whereas EPA has no such effect. The majority of studies investigating the impact of n-3 PUFA supplementation on the incidence of AF following cardiac surgery reported no benefit, though most of them did not use n-3 PUFA pretreatment for adequate duration. Studies using adequate four-week pretreatment with n-3 PUFA before cardioversion of AF showed a reduction of the AF incidence. Although n-3 PUFA have antiarrhythmogenic properties, their clinical efficacy on the prevention of AF is not consistently supported. Further well-designed studies are needed to overcome the limitations of the existing studies and provide robust conclusions.

  18. Role of Environmental Chemicals in Obesity: A Systematic Review on the Current Evidence

    Directory of Open Access Journals (Sweden)

    Roya Kelishadi

    2013-01-01

    Full Text Available The purpose of this paper is to systematically review the experimental and human studies on obesogenic chemicals and their mechanisms of action to provide a comprehensive view on the multifactorial aspects of obesity. The literatures were searched in available databases. The relevant papers were selected in three phases. After quality assessment, two reviewers extracted the data while another checked their extracted data. In this review, we summarized information regarding environmental chemicals that can be associated with obesity. Most evidence comes from experimental and laboratory studies; however a growing number of human studies also support the role of obesogenic chemicals. The current evidence proposes that the systemic responses to exposure to environmental factors could potentially increase the risk of excess weight. The effects of exposure to these chemicals are of crucial importance during developmental phases of life, when preprogramming for an adipogenic outcome may occur. By considering the adverse transgenerational effects of obesogen chemicals on human health, the global obesity epidemic should be considered as a multifactorial complex disorder necessitating the emphasis of public health interventions for environmental protection.

  19. Understanding the current state of infection preventionists through competency, role, and activity self-assessment.

    Science.gov (United States)

    Kalp, Ericka L; Marx, James F; Davis, James

    2017-06-01

    The Association for Professionals in Infection Control and Epidemiology (APIC) MegaSurvey, administered in 2015, was completed by approximately 4,079 APIC members. The survey sought to gain a better understanding the current state of 4 components of infection prevention practice: demographic characteristics, compensation, organizational structure, and practice and competency. The data for this analysis come from the APIC MegaSurvey Practice and Competency domain. Descriptive statistics and χ 2 analyses were conducted to examine differences in infection preventionist (IP) competency, roles, and activity self-assessments. The majority of IPs self-assessed their competency as Proficient compared with Novice or Expert for each of the 8 IP core competency activities. Forty percent of IPs self-rated their competency as Expert in the Preventing/Controlling the Transmission of Infectious Agents/HAIs component. IPs reported Novice competency in Employee/Occupational Health (29%); Cleaning, Sterilization, Disinfection, and Asepsis (23%); and Education and Research categories (22%). Differences in self-rated competency among IPs by discipline type (public health, nurse, and laboratory) were identified. Differences in self-rated competency were identified for each of the 8 IP core competency activities. IPs report using various resource types to gain competency. Future research is needed to identify opportunities to increase competency levels in the weakest-rated competency activities. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  20. The role of massage in sports performance and rehabilitation: current evidence and future direction.

    Science.gov (United States)

    Brummitt, Jason

    2008-02-01

    Massage is a popular treatment choice of athletes, coaches, and sports physical therapists. Despite its purported benefits and frequent use, evidence demonstrating its efficacy is scarce. To identify current literature relating to sports massage and its role in effecting an athlete's psychological readiness, in enhancing sports performance, in recovery from exercise and competition, and in the treatment of sports related musculoskeletal injuries. Electronic databases were used to identify papers relevant to this review. The following keywords were searched: massage, sports injuries, athletic injuries, physical therapy, rehabilitation, delayed onset muscle soreness, sports psychology, sports performance, sports massage, sports recovery, soft tissue mobilization, deep transverse friction massage, pre-event, and post exercise. RESEARCH STUDIES PERTAINING TO THE FOLLOWING GENERAL CATEGORIES WERE IDENTIFIED AND REVIEWED: pre-event (physiological and psychological variables), sports performance, recovery, and rehabilitation. Despite the fact clinical research has been performed, a poor appreciation exists for the appropriate clinical use of sports massage. Additional studies examining the physiological and psychological effects of sports massage are necessary in order to assist the sports physical therapist in developing and implementing clinically significant evidence based programs or treatments.

  1. Current role of cryotherapy in retinopathy of prematurity: a report by the American Academy of Ophthalmology.

    Science.gov (United States)

    Simpson, Jennifer L; Melia, Michele; Yang, Michael B; Buffenn, Angela N; Chiang, Michael F; Lambert, Scott R

    2012-04-01

    To evaluate the role of cryotherapy in the current treatment of retinopathy of prematurity (ROP). Literature searches of PubMed and the Cochrane Library were conducted on December 2, 2009, for articles published after 1984. The searches included all languages and retrieved 187 relevant citations. Thirteen articles were deemed relevant to the assessment question and were rated according to the strength of evidence. Four articles reported results from 2 large multicenter randomized clinical trials, and the remaining 9 articles reported results of 3 small randomized trials that directly compared cryotherapy and laser. Neither of the multicenter randomized clinical trials was a direct comparison of cryotherapy with laser. These studies were used to evaluate the comparative trials based on treatment criteria, study populations, and clinical results. Higher percentages of poor structural and functional outcomes generally were seen in eyes treated with cryotherapy compared with eyes undergoing laser treatment. Higher rates of systemic complications and myopia also were identified after treatment with cryotherapy. Despite a relative paucity of level I evidence directly comparing cryotherapy and laser treatment for threshold ROP, the literature suggests that neonatal facilities should gain access to laser technology and laser-trained ophthalmic staff to achieve better outcomes for treatment of the disease. Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  2. SMAD family proteins: the current knowledge on their expression and potential role in neoplastic diseases

    Directory of Open Access Journals (Sweden)

    Magdalena Witkowska

    2014-03-01

    Full Text Available Transforming growth factor beta (TGF-β plays a crucial role and takes part in many processes in the human body both in physiology and pathology. This cytokine is involved in angiogenesis, regulates apoptosis and stimulates divisions of cells, such as hepatocytes, lymphocytes or hematopoietic cells. SMAD proteins family is a unique group of particles responsible for transducting the signal induced by TGF-β into the nucleus. This molecules, after receiving a signal from activated TGF-β, act on transcription factors in the nucleus, leading directly to the expression of the corresponding genes. According to current knowledge, disturbances in the functioning of SMAD proteins are present in a number of diseases. The reduced expression was observed, for example in cardiovascular diseases such as primary pulmonary hypertension or myocardial infarction, autoimmune diseases for instance systemic lupus erythematosus and multiple sclerosis, Alzheimer’s disease or osteoporosis. The latest clinical data showed the presence of mutations in SMAD proteins in cancerogenesis. Mutation of SMAD-4 protein can be detected in half of the patients with pancreatic cancer, 20% of patients with colorectal cancer and 10% of patients with lung cancer. However, mutation in SMAD-2 protein was observed in 7% of both patients with colorectal cancer and lung cancer. On the basis of numerous works, SMAD protein expression would be valuable prognostic factor in some of neoplastic diseases.

  3. Federalism Lives.

    Science.gov (United States)

    Howard, A. E. Dick

    1987-01-01

    Examines the concept of federalism in terms of its past history and its encouraging future. Calls for a revival of concern for federalism not simply as a convenient administrative arrangement but as a fundamental constitutional value. (BSR)

  4. Emerging roles for biomedical librarians: a survey of current practice, challenges, and changes.

    Science.gov (United States)

    Crum, Janet A; Cooper, I Diane

    2013-10-01

    This study is intended to (1) identify emerging roles for biomedical librarians and determine how common these roles are in a variety of library settings, (2) identify barriers to taking on new roles, and (3) determine how librarians are developing the capacity to take on new roles. A survey was conducted of librarians in biomedical settings. Most biomedical librarians are taking on new roles. The most common roles selected by survey respondents include analysis and enhancement of user experiences, support for social media, support for systematic reviews, clinical informationist, help for faculty or staff with authorship issues, and implementation of researcher profiling and collaboration tools. Respondents in academic settings are more likely to report new roles than hospital librarians are, but some new roles are common in both settings. Respondents use a variety of methods to free up time for new roles, but predominant methods vary between directors and librarians and between academic and hospital respondents. Lack of time is the biggest barrier that librarians face when trying to adopt new roles. New roles are associated with increased collaboration with individuals and/or groups outside the library. This survey documents the widespread incorporation of new roles in biomedical libraries in the United States, as well as the barriers to adopting these roles and the means by which librarians are making time for them. The results of the survey can be used to inform strategic planning, succession planning, library education, and career development for biomedical librarians.

  5. Understanding Federalism.

    Science.gov (United States)

    Hickok, Eugene W., Jr.

    1990-01-01

    Urges returning to the original federalist debates to understand contemporary federalism. Reviews "The Federalist Papers," how federalism has evolved, and the centralization of the national government through acts of Congress and Supreme Court decisions. Recommends teaching about federalism as part of teaching about U.S. government…

  6. Revisiting the role of trap-assisted-tunneling process on current-voltage characteristics in tunnel field-effect transistors

    Science.gov (United States)

    Omura, Yasuhisa; Mori, Yoshiaki; Sato, Shingo; Mallik, Abhijit

    2018-04-01

    This paper discusses the role of trap-assisted-tunneling process in controlling the ON- and OFF-state current levels and its impacts on the current-voltage characteristics of a tunnel field-effect transistor. Significant impacts of high-density traps in the source region are observed that are discussed in detail. With regard to recent studies on isoelectronic traps, it has been discovered that deep level density must be minimized to suppress the OFF-state leakage current, as is well known, whereas shallow levels can be utilized to control the ON-state current level. A possible mechanism is discussed based on simulation results.

  7. The crucial role of habits in energy consumption: an evolutionary approach on changing current patterns

    Energy Technology Data Exchange (ETDEWEB)

    Marechal, Kevin (Centre for Economic and Social Studies on the Environment (CESSE), Univ. Libre de Bruxelles, Univ. d' Europe (Belgium)). e-mail: kevin.marechal@ulb.ac.be

    2009-07-01

    A substantial body of literature has shown that our behaviour is often guided by habits. The existence of habits - not fully conscious forms of behaviour - is important as it contradicts rational choice theory. Their presence thus calls for the setting of new instruments as they make it unlikely that consumers be capable of exercising control over their energy consumption in reaction to given incentives. This is further increased in the evolutionary perspective where the current carbon-based Socio-Technical System constraints and shapes consumers' choices through structural forces. Habits being potentially 'counterintentional', they may explain the 'efficiency paradox' in energy as well as the continued increase of energy consumption despite the rising environmental awareness among the population. Policies aiming at reducing energy consumption should thus specifically address the performance context of habits. For instance, targeting new residents has proven to be more effective given that their preceding habits have been disturbed. The results of our empirical analysis confirm this idea by showing how a change of context makes people more receptive to a proposed measure. Our analysis of the role played by habits also suggests that individuals do not consider the need to change existing habits as an obstacle even though this is contradicted implicitly in the answers they provided to open questions. This 'unconsciousness' is one of the most delicate features of habits and it should thus be accounted for when designing measures. Given the other characteristics of habits, the joint use of feedbacks and commitment strategies appears promising.

  8. Management of hypercalcaemic crisis in adults: Current role of renal replacement therapy.

    Science.gov (United States)

    Bentata, Yassamine; El Maghraoui, H; Benabdelhak, M; Haddiya, I

    2018-06-01

    Neoplasms and hematologic diseases are the predominant etiologies of hypercalcemic crisis in adults and the immediate treatment is mainly medical and symptomatic. The use of renal replacement therapy (RRT) is often necessary to correct the hypercalcemia, uremia and electrolyte disturbances related to Acute Kidney Injury (AKI). The aim of this work was to determine the etiologies and the place of RRT in treating patients with hypercalcaemic crisis. We conducted a retrospective study for 36months at the Nephrology Unit, University Hospital, Oujda, eastern of Morocco. We included all adult patients diagnosed with hypercalcemic crisis that was defined as corrected total serum calcium of >3.5mmol/l. 12 patients were collected. All patients were female and 5 patients were elderly (≥65years). Three patients had a serum calcium value of >4mmol/l and the highest calcium value was 5.8mmol/l. Electrocardiographic abnormalities were observed in 8 cases. AKI was observed in 8 cases. Three patients had chronic kidney disease on hemodialysis. Neoplasm was noted in 9 cases. All patients received venous rehydration, glucocorticoids and biphosphonates. The use of RRT with low calcium dialysate was performed in 11 cases. Three patients died during the first 24h of hospitalization. RRT must play its full role as first line treatment of hypercalcemia crisis. Improvements in hemodialysis techniques and the use of low calcium or calcium-free dialysates currently allows this therapeutic measure to be prescribed safely, and the benefit-risk balance is positive for the great benefit provided by dialysis. Copyright © 2018 Elsevier Inc. All rights reserved.

  9. Child obesity prevention in primary health care: investigating practice nurse roles, attitudes and current practices.

    Science.gov (United States)

    Robinson, Alison; Denney-Wilson, Elizabeth; Laws, Rachel; Harris, Mark

    2013-04-01

    Overweight and obesity affects approximately 20% of Australian pre-schoolers. The general practice nurse (PN) workforce has increased in recent years; however, little is known of PN capacity and potential to provide routine advice for the prevention of child obesity. This mixed methods pilot study aims to explore the current practices, attitudes, confidence and training needs of Australian PNs surrounding child obesity prevention in the general practice setting. PNs from three Divisions of General Practice in New South Wales were invited to complete a questionnaire investigating PN roles, attitudes and practices in preventive care with a focus on child obesity. A total of 59 questionnaires were returned (response rate 22%). Semi-structured qualitative interviews were also conducted with a subsample of PNs (n = 10). Questionnaire respondent demographics were similar to that of national PN data. PNs described preventive work as enjoyable despite some perceived barriers including lack of confidence. Number of years working in general practice did not appear to strongly influence nurses' perceived barriers. Seventy per cent of PNs were interested in being more involved in conducting child health checks in practice, and 85% expressed an interest in taking part in child obesity prevention training. Findings from this pilot study suggest that PNs are interested in prevention of child obesity despite barriers to practice and low confidence levels. More research is needed to determine the effect of training on PN confidence and behaviours in providing routine healthy life-style messages for the prevention of child obesity. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  10. Emerging Roles of Women in the National Food Security Campaign of the Federal Government of Nigeria: A Review

    OpenAIRE

    Ademilua, O.S; Adeeko, A; Gbotoso, O.A; Akomolafe, A.M; Ishola, O.O

    2017-01-01

    The issue of food security in Nigeria is of national concern as it affects young and old, male and female. The review assessed the emerging roles of women and their contributions to food security in Nigeria. Specifically, it explained the concept of food security, identified the specific roles of women in food security and identified factors affecting women participation in national food security. Food security is a situation that exist when all people at all times, have physical, social and ...

  11. A Self-Instructional Course in Student Financial Aid Administration. Module 2--Federal Student Financial Aid: History & Current Sources. Second Edition.

    Science.gov (United States)

    Washington Consulting Group, Inc., Washington, DC.

    The second of 17 modules in a self-instructional course on student financial aid administration, this module offers novice financial aid administrators and other institutional personnel a systematic introduction to the management of federal financial aid programs authorized by the Higher Education Act Title IV. It traces the history of federal…

  12. The role of First Nations in oil and gas development under federal regulatory regimes: Options for change and lessons from New Zealand

    Energy Technology Data Exchange (ETDEWEB)

    Davis, T. R. [Borden, Ladner, Gervais, LLP., Ottawa, ON (Canada)

    2001-07-01

    This thesis was prepared at the University of Ottawa in partial fulfillment of the requirements for the degree of Master of Laws (LL.M.). It is included here in its entirety. It outlines the role played by First Nations under federal oil and gas regulatory regimes and makes recommendations designed to enable First Nations groups to participate in oil and gas development. A persuasive argument is made on legal and policy grounds for an active role for First Nations in oil and gas development within their traditional territories. This position is supported by a comprehensive analysis of three federal oil and gas regimes -- the Northern, Offshore and Indian Reserve regimes -- their legislative frameworks and recent developments in aboriginal jurisprudence and policy. Further support for the recommendations is adduced by comparing the Canadian situation with relevant contemporary resource management issues in New Zealand. The author recommends the immediate creation of a Consultation Model for a range of consultation processes that vary depending upon the nature of the issue. Over the longer term, development of First Nation Models is recommended. These models should be adjustable by careful monitoring of the successes and failures of First Nation oil and gas management regimes under Comprehensive Land Claim Agreements. It is suggested that internal capacity issues with respect to infrastructure and expertise must be addressed before First Nation groups can establish economically viable oil and gas models. [320 refs.].

  13. Role of oral pre-exposure prophylaxis (PrEP) in current and future HIV prevention strategies.

    Science.gov (United States)

    Burns, David N; Grossman, Cynthia; Turpin, Jim; Elharrar, Vanessa; Veronese, Fulvia

    2014-12-01

    Treatment as prevention is expected to have a major role in reducing HIV incidence, but other prevention interventions will also be required to bring the epidemic under control, particularly among key populations. One or more forms of pre-exposure prophylaxis (PrEP) will likely play a critical role. Oral PrEP with emtricitabine-tenofovir (Truvada®) is currently available in the US and some other countries, but uptake has been slow. We review the concerns that have contributed to this slow uptake and discuss current and future research in this critical area of HIV prevention research.

  14. External and internal accidents in PWR power plants. Comparison of current regulations in Belgium, United States, France, Federal Republic of Germany and United Kingdom

    International Nuclear Information System (INIS)

    Maere, G. de; Roch, M.; Cavaco, A.; Preat, M.

    1986-01-01

    In this report a comparison is made of the rules and practices applied in various countries (Belgium, France, Federal Republic of Germany, United Kingdom and United States of America) in designing PWR plants to resist natural hazards (first part of the report) and hazards associated with human activities (second part). The third part of the report deals with the practices in different countries concerning the protection against accidents of internal origin [fr

  15. Parental Smoking and Adolescent Smoking Stages: The Role of Parents' Current and Former Smoking, and Family Structure

    NARCIS (Netherlands)

    Otten, R.; Engels, R.C.M.E.; Ven, M.O.M. van de; Bricker, J.B.

    2007-01-01

    This study examined the role of parents’ current and former smoking in predicting adolescent smoking acquisition stages. Participants were 7,426 students from 33 schools in the Netherlands. Participants’ survey data were gathered at baseline and at two-year follow-up. Logistic regression models

  16. The role of nonlinear beating currents on parametric instabilities in magnetoplasmas

    International Nuclear Information System (INIS)

    Kuo, S.P.

    1996-01-01

    A general coupled mode equation for the low-frequency decay modes of parametric instabilities in magnetoplasmas is derived. The relative importance of the nonlinear contributions from the ponderomotive force, nonlinear beating current, and anisotropic effect to the parametric coupling is then manifested by the coupling terms of the equation. It is first shown in the unmagnetized case, that the contribution of the nonlinear beating current is negligibly small because of the small coefficient (i.e., weight) of this current contribution, instead of the beating current itself. It then follows that the weight of the beating current contribution increases significantly in the magnetized case, and consequently, this contribution to the parametric coupling is found to be important, as exemplified by two specific examples. copyright 1996 American Institute of Physics

  17. What Is the Role of Survivability Operations in the Current Force?

    National Research Council Canada - National Science Library

    Smallfield, Jason

    2003-01-01

    .... The problem, however, is that most of these changes do not adequately address the role that survivability operations should play across the full spectrum of conflict at the tactical level of warfare...

  18. Current Research of the Roles of IL-35 in Tumor Progression

    Directory of Open Access Journals (Sweden)

    Chongbiao HUANG

    2016-04-01

    Full Text Available Interleukin(IL-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of an α chain P35 and a β chain Epstein-Barr virus induced gene 3 (EBI3. Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inflammatory diseases and autoimmune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression.

  19. The adequacy of measures of gender roles attitudes: a review of current measures in omnibus surveys.

    Science.gov (United States)

    Walter, Jessica Gabriele

    2018-01-01

    The measures of attitudes toward gender roles included in many representative international and national omnibus surveys were developed mostly in the 1970s and 1980s with a focus on the male breadwinner model. This article deals with the issue of whether the measures provided in these omnibus surveys need to be adjusted to specific social changes. A review of these measures has found that adjustments have occurred in a limited way that focused on the role of women and disregarded the role of men. Furthermore, most of these measures only examined the traditional roles of men and women. More egalitarian role models have not been considered sufficiently. In addition, most items that have been measured are phrased in a general form and, for example, do not specify parents' employment or the ages of children. A specification of these aspects of measurement would help to clarify the conceptual meaning of the results and increase the possibility of more accurately analyzing gender role attitudes over time.

  20. The South East Asian Federation of Organizations for Medical Physics (SEAFOMP): Its history and role in the ASEAN countries.

    Science.gov (United States)

    Ng, Kh; Wong, Jhd

    2008-04-01

    Informal discussion started in 1996 and the South East Asian Federation of Organizations for Medical Physics (SEAFOMP) was officially accepted as a regional chapter of the IOMP at the Chicago World Congress in 2000 with five member countries, namely Indonesia, Malaysia, Philippines, Singapore and Thailand. Professor Kwan-Hoong Ng served as the founding president until 2006. Brunei (2002) and Vietnam (2005) joined subsequently. We are very grateful to the founding members of SEAFOMP: Anchali Krisanachinda, Kwan-Hoong Ng, Agnette Peralta, Ratana Pirabul, Djarwani S Soejoko and Toh-Jui Wong.The objectives of SEAFOMP are to promote (i) co-operation and communication between medical physics organizations in the region; (ii) medical physics and related activities in the region; (iii) the advancement in status and standard of practice of the medical physics profession; (iv) to organize and/or sponsor international and regional conferences, meetings or courses; (v) to collaborate or affiliate with other scientific organizations.SEAFOMP has been organizing a series of congresses to promote scientific exchange and mutual support. The South East Asian Congress of Medical Physics (SEACOMP) series was held respectively in Kuala Lumpur (2001), Bangkok (2003), Kuala Lumpur (2004) and Jakarta (2006). The respective congress themes indicated the emphasis and status of development. The number of participants (countries in parentheses) was encouraging: 110 (17), 150 (16), 220 (23) and 126 (7).In honour of the late Professor John Cameron, an eponymous lecture was established. The inaugural John Cameron Lecture was delivered by Professor Willi Kalender in 2004. His lecture was titled "Recent Developments in Volume CT Scanning".

  1. On the role of topological complexity in spontaneous development of current sheets

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Sanjay; Bhattacharyya, R. [Udaipur Solar Observatory, Physical Research Laboratory, Dewali, Bari Road, Udaipur-313001 (India); Smolarkiewicz, P. K. [European Centre for Medium-Range Weather Forecasts, Reading RG2 9AX (United Kingdom)

    2015-08-15

    The computations presented in this work aim to asses the importance of field line interlacing on spontaneous development of current sheets. From Parker's magnetostatic theorem, such development of current sheets is inevitable in a topologically complex magnetofluid, with infinite electrical conductivity, at equilibrium. Relevant initial value problems are constructed by superposition of two untwisted component fields, each component field being represented by a pair of global magnetic flux surface. The intensity of field line interlacing is then specified by the relative amplitude of the two superposed fields. The computations are performed by varying this relative amplitude. Also to have a direct visualization of current sheet formation, we follow the evolution of flux surfaces instead of the vector magnetic field. An important finding of this paper is in the demonstration that initial field lines having intense interlacing tend to develop current sheets which are distributed throughout the computational domain with no preference for topologically favorable sites like magnetic nulls or field reversal layers. The onsets of these current sheets are attributed to favorable contortions of magnetic flux surfaces where two oppositely directed parts of the same field line or different field lines come to close proximity. However, for less intensely interlaced field lines, the simulations indicate development of current sheets at sites only where the magnetic topology is favorable. These current sheets originate as two sets of anti-parallel complimentary field lines press onto each other.

  2. A 2D finite element study on the role of material properties on eddy current losses in soft magnetic composites

    Science.gov (United States)

    Ren, Xiaotao; Corcolle, Romain; Daniel, Laurent

    2016-02-01

    The use of soft magnetic composites (SMCs) in electrical engineering applications is growing. SMCs provide an effective alternative to laminated steels because they exhibit a high permeability with low eddy current losses. Losses are a critical feature in the design of electrical machines, and it is necessary to evaluate the role of microstructure and constitutive properties of SMCs during the predesign stage. In this paper we propose a simplified finite element approach to compute eddy current losses in these materials. The computations allow to quantify the role of exciting source and material properties on eddy current losses. This analysis can later be used in the development of homogenization models for SMC. Contribution to the topical issue "Numelec 2015 - Elected submissions", edited by Adel Razek

  3. The role of substorms in the formation of the ring current

    International Nuclear Information System (INIS)

    Rostoker, G.

    1996-01-01

    It has long been recognized that the formation of the terrestrial ring current is accompanied by strong substorm expansive phase activity in the auroral oval. While large amplitude substorm activity seems to be a prerequisite for ring current formation to take place, it has long been puzzling as to why some large amplitude substorm activity in the auroral oval is not associated with significant ring current development. In this paper I shall outline the basis for the renovated boundary layer dynamics model of magnetospheric substorms showing how the onset of the substorm expansive phase can be associated with a sudden decrease in shielding space charge in the region of the near-Earth plasma sheet threaded by Region 2 field-aligned currents. I shall suggest that an episode of sufficiently large southward IMF lasting over a sufficiently lengthy period of time can lead to a sequence of substorm expansive phases, each one being initiated closer to the Earth than the previous one. Each expansive phase is attributed to a sudden decrease in radially localized cross-tail current (viz. a decrease in shielding space charge) and with each onset the inner edge of the plasma sheet moves inward. The inductive electric field associated with each crosstail current decrease is responsible for the acceleration of already energetic particles to energies of significance for ring current formation. Only when the inner edge of the crosstail current is sufficiently close to the Earth do the acceleration processes associated with substorm onset produce a long lived ring current. copyright 1996 American Institute of Physics

  4. PERFORMANCE DETERMINANTS OF PARTICIPATION BANKS: THE ROLE OF SPECIAL CURRENT ACCOUNTS

    Directory of Open Access Journals (Sweden)

    Yusuf DINÇ

    2017-02-01

    Full Text Available Participation banks collect participation funds for credit allocation by participation accounts and special current accounts as main function. Profit or loss offered to participation accounts on base of participation share ratio while special current accounts are considered as cost-free resources. Participation funds are used in the models that analyze participation banks’ performance. Although participation fund types are not considered as variables also special current accounts. This research brings suggestions for the variables for performance analysis of participation banks for further researches.

  5. Federal Investment

    Science.gov (United States)

    Campbell, Sheila; Tawil, Natalie

    2013-01-01

    The federal government pays for a wide range of goods and services that are expected to be useful some years in the future. Those purchases, called investment, fall into three categories: physical capital, research and development (R&D), and education and training. There are several economic rationales for federal investment. It can provide…

  6. Role of current algebra in B→pp-barπ(π)

    International Nuclear Information System (INIS)

    Paver, N.; Riazuddin.

    1987-11-01

    We estimate in a current algebra framework the hadronic matrix elements relevant to the weak B→pp-barπ(π) transitions measured recently. The results so obtained are in agreement with the observed values. (author). 11 refs, 1 fig

  7. The role of history in understanding current South African attitudes to ...

    African Journals Online (AJOL)

    Southern African Journal of Environmental Education. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 10 (1989) >. Log in or Register to get access to full text downloads.

  8. Current Opinions and Areas of Consensus on the Role of the Cerebellum in Dystonia.

    Science.gov (United States)

    Shakkottai, Vikram G; Batla, Amit; Bhatia, Kailash; Dauer, William T; Dresel, Christian; Niethammer, Martin; Eidelberg, David; Raike, Robert S; Smith, Yoland; Jinnah, H A; Hess, Ellen J; Meunier, Sabine; Hallett, Mark; Fremont, Rachel; Khodakhah, Kamran; LeDoux, Mark S; Popa, Traian; Gallea, Cécile; Lehericy, Stéphane; Bostan, Andreea C; Strick, Peter L

    2017-04-01

    A role for the cerebellum in causing ataxia, a disorder characterized by uncoordinated movement, is widely accepted. Recent work has suggested that alterations in activity, connectivity, and structure of the cerebellum are also associated with dystonia, a neurological disorder characterized by abnormal and sustained muscle contractions often leading to abnormal maintained postures. In this manuscript, the authors discuss their views on how the cerebellum may play a role in dystonia. The following topics are discussed: The relationships between neuronal/network dysfunctions and motor abnormalities in rodent models of dystonia. Data about brain structure, cerebellar metabolism, cerebellar connections, and noninvasive cerebellar stimulation that support (or not) a role for the cerebellum in human dystonia. Connections between the cerebellum and motor cortical and sub-cortical structures that could support a role for the cerebellum in dystonia. Overall points of consensus include: Neuronal dysfunction originating in the cerebellum can drive dystonic movements in rodent model systems. Imaging and neurophysiological studies in humans suggest that the cerebellum plays a role in the pathophysiology of dystonia, but do not provide conclusive evidence that the cerebellum is the primary or sole neuroanatomical site of origin.

  9. Greater Role of Geostrophic Currents on Ekman Dynamics in the Western Arctic Ocean as a Mechanism for Beaufort Gyre Stabilization

    Science.gov (United States)

    Steele, M.; Zhong, W.; Zhang, J.; Zhao, J.

    2017-12-01

    Seven different methods, with and without including geostrophic currents, were used to explore Ekman dynamics in the western Arctic Ocean for the period 1992-2014. Results show that surface geostrophic currents have been increasing and are much stronger than Ekman layer velocities in recent years (2003-2014) when the oceanic Beaufort Gyre (BG) is spinning up in the region. The new methods that include geostrophic currents result in more realistic Ekman pumping velocities than a previous iterative method that does not consider geostrophic currents and therefore overestimates Ekman pumping velocities by up to 52% in the central area of the BG over the period 2003-2014. When the BG is spinning up as seen in recent years, geostrophic currents become stronger, which tend to modify the ice-ocean stress and to cause an Ekman divergence that counteracts wind-driven Ekman convergence in the Canada Basin. This is a mechanism we have identified to play an important and growing role in stabilizing the Ekman convergence and therefore the BG in recent years. This mechanism may be used to explain three scenarios that describe the interplay of changes in wind forcing, sea ice motion, and geostrophic currents that control the variability of the Ekman dynamics in the central BG during 1992-2014. Results also reveal several upwelling regions in the southern and northern Canada Basin and the Chukchi Abyssal Plain which may plays a significant role in biological processes in these regions.

  10. Greater Role of Geostrophic Currents in Ekman Dynamics in the Western Arctic Ocean as a Mechanism for Beaufort Gyre Stabilization

    Science.gov (United States)

    Zhong, Wenli; Steele, Michael; Zhang, Jinlun; Zhao, Jinping

    2018-01-01

    Seven different methods, with and without including geostrophic currents, were used to explore Ekman dynamics in the western Arctic Ocean for the period 1992-2014. Results show that surface geostrophic currents have been increasing and are much stronger than Ekman layer velocities in recent years (2003-2014) when the oceanic Beaufort Gyre (BG) is spinning up in the region. The new methods that include geostrophic currents result in more realistic Ekman pumping velocities than a previous iterative method that does not consider geostrophic currents and therefore overestimates Ekman pumping velocities by up to 52% in the central area of the BG over the period 2003-2014. When the BG is spinning up as seen in recent years, geostrophic currents become stronger, which tend to modify the ice-ocean stress and moderate the wind-driven Ekman convergence in the Canada Basin. This is a mechanism we have identified to play an important and growing role in stabilizing the Ekman convergence and therefore the BG in recent years. This mechanism may be used to explain three scenarios that describe the interplay of changes in wind forcing, sea ice motion, and geostrophic currents that control the variability of the Ekman dynamics in the central BG during 1992-2014. Results also reveal several upwelling regions in the southern and northern Canada Basin and the Chukchi Abyssal Plain which may play a significant role in physical and biological processes in these regions.

  11. Roles Prioritization of Hydrogen Production Technologies for Promoting Hydrogen Economy in the Current State of China

    DEFF Research Database (Denmark)

    Ren, Jingzheng; Gao, Suzhao; Tan, Shiyu

    2015-01-01

    Hydrogen production technologies play an important role in the hydrogen economy of China. However, the roles of different technologies played in promoting the development of hydrogen economy are different. The role prioritization of various hydrogen production technologies is of vital importance...... information. The prioritization results by using the proposed method demonstrated that the technologies of coal gasification with CO2 capture and storage and hydropower-based water electrolysis were regarded as the two most important hydrogen production pathways for promoting the development of hydrogen...... for the stakeholders/decision-makers to plan the development of hydrogen economy in China and to allocate the finite R&D budget reasonably. In this study, DPSIR framework was firstly used to identify the key factors concerning the priorities of various hydrogen production technologies; then, a fuzzy group decision...

  12. The Context of Current Content Analysis of Gender Roles: An Introduction to a Special Issue

    Science.gov (United States)

    Popova, Lucy; Linz, Daniel G.

    2010-01-01

    The aim of this paper is to provide context for the quantitative content analyses of gender roles that are to be included in both parts of this special issue. First, a timeline of historical uses of the content analysis methodology is presented. Second, research objectives that frequently drive content analysis of gender roles are described; these include: to support feminist claims, to compare media with real life, to predict effects on audiences, and to detect effects of media producers on content. Third, previous content analyses published in Sex Roles and other gender-focused journals are reviewed and categorized in terms of medium, genre, time span, gender, and nationality. Finally, contributions of each of the articles in this special issue are outlined. PMID:20694031

  13. Sausage instabilities in the electron current layer and its role in the concept of fast ignition

    International Nuclear Information System (INIS)

    Das, Amita; Jain, Neeraj; Kaw, Predhiman; Sengupta, Sudip

    2004-01-01

    The fast ignition concept of laser fusion utilizes hot electrons produced at the surface of the target by an incident intense laser pulse for the creation of the hot spot for ignition. As the hot electrons move inwards to the core of the precompressed target, the electrons from the background plasma provide a return shielding current. Three dimensional PIC simulations have shown that intense Weibel, tearing and coalescence instabilities take place which organize the current distribution into a few current filaments. In each of these filaments the central core region constitutes a current due to the fast electrons propagating inwards towards the pellet core, while the outer cylindrical shell region carries the return shielding current. The presence of instabilities and their subsequent nonlinear development can hinder the propagation of fast electrons towards the core influencing the location of the hot spot for ignition. Earlier studies showing the existence of sausage-like modes were carried out in the nonrelativistic limit and under the assumption of equal electron densities of the fast and the cold electrons. The fast electron density, in general, differs considerably from the background plasma density as it is dependent on the incident laser intensity. This paper incorporates relativistic effects and also studies the dependence of the growth rate on the fast electron density. Finally, nonlinear saturation of the instability and its impact on the stopping of the fast electron motion towards the core have also been investigated using numerical simulations. The simulations have, however, currently been carried out for non-relativistic dynamics. The results show that the sheared velocity profile of the channel gets flattened, causing an effective drop in the inward moving current. (author)

  14. [Current cases of falsified medicinal products within the competence of the Federal Institute for Drugs and Medical Devices (BfArM) : Case studies and extent].

    Science.gov (United States)

    Wittstock, Marcus; Paeschke, Norbert

    2017-11-01

    The nature of a falsification of a medicinal product can vary a lot. Therefore the means to detect them and the potential risk to patient safety can also be very different. The whole range of falsification will be described using observed cases from the Federal Institute for Drugs and Medical Devices (BfArM).Based on the relatively low number of detected cases of falsified medicines, the legal supply chain can still be regarded as safe. It has to be assumed that in the illegal supply chain, e. g. illegal internet trade, the majority of the offered medicinal products are not only falsifications due to illegal trade but because they are completely falsified. Therefore there is an especially high risk for the consumer to be harmed by medicinal products that do not fulfil the required specifications.The trend indicates that increased efforts will be necessary to keep the legal supply chain safe and to contain illegal trade with falsifications. The higher federal authorities BfArM, PEI and BVL are involved in this task by coordinating and ensuring the flow of information to the concerned authorities and stakeholders as well as informing the public. Increased efforts are also necessary due to the rising involvement of organised crime in the falsification of medicinal products. A package of measures was enacted with the Falsified Medicines Directive 2011/62/EU to protect the legal supply chain from falsified medicinal products.

  15. On the role of fusion neutron source with thorium blanket in forming the nuclide composition of the nuclear fuel cycle of the Russian Federation

    Energy Technology Data Exchange (ETDEWEB)

    Shmelev, A. N.; Kulikov, G. G., E-mail: ggkulikov@mephi.ru [National Research Nuclear University (Moscow Engineering Physics Institute) (Russian Federation)

    2016-12-15

    The possible role of available thorium resources of the Russian Federation in utilization of thorium in the closed (U–Pu)-fuel cycle of nuclear power is considered. The efficiency of application of fusion neutron sources with thorium blanket for economical use of available thorium resources is demonstrated. The objective of this study is the search for a solution of such major tasks of nuclear power as reduction of the amount of front-end operations in the nuclear fuel cycle and enhancement of its protection against uncontrolled proliferation of fissile materials with the smallest possible alterations in the fuel cycle. The earlier results are analyzed, new information on the amount of thorium resources of the Russian Federation is used, and additional estimates are made. The following basic results obtained on the basis of the assumption of involving fusion reactors with Th-blanket in future nuclear power for generation of the light uranium fraction {sup 232+233+234}U and {sup 231}Pa are formulated. (1) The fuel cycle would shift from fissile {sup 235}U to {sup 233}U, which is more attractive for thermal power reactors. (2) The light uranium fraction is the most “protected” in the uranium fuel component, and being mixed with regenerated uranium, it would become reduced-enrichment uranium fuel, which would relieve the problem of nonproliferation of the fissile material. (3) The addition of {sup 231}Pa into the fuel would stabilize its neutron-multiplying properties, thus making it possible to implement a long fuel residence time and, as a consequence, increase the export potential of the whole nuclear power technology. (4) The available thorium resource in the vicinity of Krasnoufimsk is sufficient for operation of the large-scale nuclear power industry of the Russian Federation with an electric power of 70 GW for more than one quarter of a century. The general conclusion is that involvement of a small number of fusion reactors with Th-blanket in the future

  16. THE ROLE OF INFORMATION TECHNOLOGIES IN THE PROCESS OF PROFESSIONAL TRAINING OF CADETS OF NATIONAL GUARD TROOPS OF THE RUSSIAN FEDERATION

    Directory of Open Access Journals (Sweden)

    O. A. Kozlov

    2016-01-01

    Full Text Available The purpose of this article is to identify the role of information technology in daily process of training of cadets of military schools of national guard troops of theRussian Federation.Methods. The methods involve system-oriented analysis, generalization and modelling.Results and scientific novelty. Informatization of modern society is characterized by growing use of information resources for different spheres of professional activity, suggesting radical changes in the content and technologies of its organization. The problems of informatization of the Russian higher military school are revealed: absence of the uniform methodology for implementation of new information technologies in educational process; low level of cooperation and coordination of activities of educational institutions during creation of a uniform basis of the software; insufficient training of the faculty, etc. The informatization process of military service and military experts of national guard troops of theRussian Federation as members of the security institute in the structure of the state is primarily associated with the creation and maintenance of necessary level of the equipment in order to solve professional tasks in various conditions of the operational environment. Modern realias dictate the need of search of ways and means of improvement of information literacy of cadets of departmental higher education institutions of national guard troops of theRussian Federation. The author of article has designated the main directions of intensive informatization of education of future army officers. The system use of a complex of information technologies of the general and special purpose in educational process of military higher education institution is described. The options of integration of these technologies in the contents of training sections of military experts are shown. Special attention is paid to opportunities of distance learning.Practical significance. The

  17. Radiology Physician Extenders: A Literature Review of the History and Current Roles of Physician Extenders in Medical Imaging.

    Science.gov (United States)

    Sanders, Vicki L; Flanagan, Jennifer

    2015-01-01

    The purpose of the literature review was to assess the origins of radiology physician extenders and examine the current roles found in the literature of advanced practice physician extenders within medical imaging. Twenty-six articles relating to physician assistants (PAs), nurse practitioners (NPs), radiologist assistants (RAs), and nuclear medicine advanced associates (NMAAs) were reviewed to discern similarities and differences in history, scope of practice, and roles in the medical imaging field. The literature showed PAs and NPs are working mostly in interventional radiology. PAs, NPs, and RAs perform similar tasks in radiology, including history and physicals, evaluation and management, preprocedure work-up, obtaining informed consent, initial observations/reports, and post-procedure follow-up. NPs and PAs perform a variety of procedures but most commonly vascular access, paracentesis, and thoracentesis. RAs perform gastrointestinal, genitourinary, nonvascular invasive fluoroscopy procedures, and vascular access procedures. The review revealed NMAAs are working in an advanced role, but no specific performances of procedures was found in the literature, only suggested tasks and clinical competencies. PAs, NPs, and RAs are currently the three main midlevel providers used in medical imaging. These midlevel providers are being used in a variety of ways to increase the efficiency of the radiologist and provide diagnostic and therapeutic radiologic procedures to patients. NMAAs are being used in medical imaging but little literature is available on current roles in clinical practice. More research is needed to assess the exact procedures and duties being performed by these medical imaging physician extenders.

  18. A gestão da atenção às urgências e o protagonismo federal Management of attention to emergency rooms and the federal role

    Directory of Open Access Journals (Sweden)

    Gisele O'Dwyer

    2010-08-01

    proposals as the facilitator trend of the structural resource, innovative due to the regionalization and responsibilization proposals presented by the several actors and by the alleged centrality of the user. The financing of SUS, despite its persistent state of embarrassment, had no coercive action on the technology investment. Under the current administration there was a vigorous expansion and structuring of the network, which was made by a strong inflow of federal funds. The management by committees should be investigated and points out how fragile the management of labor is.

  19. Current flow in random resistor networks: the role of percolation in weak and strong disorder.

    Science.gov (United States)

    Wu, Zhenhua; López, Eduardo; Buldyrev, Sergey V; Braunstein, Lidia A; Havlin, Shlomo; Stanley, H Eugene

    2005-04-01

    We study the current flow paths between two edges in a random resistor network on a L X L square lattice. Each resistor has resistance e(ax) , where x is a uniformly distributed random variable and a controls the broadness of the distribution. We find that: (a) The scaled variable u identical with u congruent to L/a(nu) , where nu is the percolation connectedness exponent, fully determines the distribution of the current path length l for all values of u . For u > 1, the behavior corresponds to the weak disorder limit and l scales as l approximately L, while for u < 1 , the behavior corresponds to the strong disorder limit with l approximately L(d(opt) ), where d(opt) =1.22+/-0.01 is the optimal path exponent. (b) In the weak disorder regime, there is a length scale xi approximately a(nu), below which strong disorder and critical percolation characterize the current path.

  20. Advanced practice registered nurses and physician assistants in sleep centers and clinics: a survey of current roles and educational background.

    Science.gov (United States)

    Colvin, Loretta; Cartwright, Ann; Collop, Nancy; Freedman, Neil; McLeod, Don; Weaver, Terri E; Rogers, Ann E

    2014-05-15

    To survey Advanced Practice Registered Nurse (APRN) and Physician Assistant (PA) utilization, roles and educational background within the field of sleep medicine. Electronic surveys distributed to American Academy of Sleep Medicine (AASM) member centers and APRNs and PAs working within sleep centers and clinics. Approximately 40% of responding AASM sleep centers reported utilizing APRNs or PAs in predominantly clinical roles. Of the APRNs and PAs surveyed, 95% reported responsibilities in sleep disordered breathing and more than 50% in insomnia and movement disorders. Most APRNs and PAs were prepared at the graduate level (89%), with sleep-specific education primarily through "on the job" training (86%). All APRNs surveyed were Nurse Practitioners (NPs), with approximately double the number of NPs compared to PAs. APRNs and PAs were reported in sleep centers at proportions similar to national estimates of NPs and PAs in physicians' offices. They report predominantly clinical roles, involving common sleep disorders. Given current predictions that the outpatient healthcare structure will change and the number of APRNs and PAs will increase, understanding the role and utilization of these professionals is necessary to plan for the future care of patients with sleep disorders. Surveyed APRNs and PAs reported a significant deficiency in formal and standardized sleep-specific education. Efforts to provide formal and standardized educational opportunities for APRNs and PAs that focus on their clinical roles within sleep centers could help fill a current educational gap.

  1. Current-oriented swimming by jellyfish and its role in bloom maintenance.

    Science.gov (United States)

    Fossette, Sabrina; Gleiss, Adrian Christopher; Chalumeau, Julien; Bastian, Thomas; Armstrong, Claire Denise; Vandenabeele, Sylvie; Karpytchev, Mikhail; Hays, Graeme Clive

    2015-02-02

    Cross-flows (winds or currents) affect animal movements [1-3]. Animals can temporarily be carried off course or permanently carried away from their preferred habitat by drift depending on their own traveling speed in relation to that of the flow [1]. Animals able to only weakly fly or swim will be the most impacted (e.g., [4]). To circumvent this problem, animals must be able to detect the effects of flow on their movements and respond to it [1, 2]. Here, we show that a weakly swimming organism, the jellyfish Rhizostoma octopus, can orientate its movements with respect to currents and that this behavior is key to the maintenance of blooms and essential to reduce the probability of stranding. We combined in situ observations with first-time deployment of accelerometers on free-ranging jellyfish and simulated the behavior observed in wild jellyfish within a high-resolution hydrodynamic model. Our results show that jellyfish can actively swim countercurrent in response to current drift, leading to significant life-history benefits, i.e., increased chance of survival and facilitated bloom formation. Current-oriented swimming may be achieved by jellyfish either directly detecting current shear across their body surface [5] or indirectly assessing drift direction using other cues (e.g., magnetic, infrasound). Our coupled behavioral-hydrodynamic model provides new evidence that current-oriented swimming contributes to jellyfish being able to form aggregations of hundreds to millions of individuals for up to several months, which may have substantial ecosystem and socioeconomic consequences [6, 7]. It also contributes to improve predictions of jellyfish blooms' magnitude and movements in coastal waters. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. The role of latency reversal agents in the cure of HIV: A review of current data.

    Science.gov (United States)

    Bashiri, Kiandokht; Rezaei, Nima; Nasi, Milena; Cossarizza, Andrea

    2018-04-01

    The definitive cure for human immunodeficiency virus type-1 (HIV) infection is represented by the eradication of the virus from the patient's body. To reach this result, cells that are infected but do not produce the virus must become recognizable to be killed by the immune system. For this purpose, drugs defined "latency reverting agents" (LRA) that reactivate viral production are under investigation. A few clinical studies have been performed in HIV-infected patients treated with LRA and combined antiretroviral therapy (cART). The strategy is thus to combine cART and LRA to reactivate the virus and unmask latently infected cells that, because of cART, cannot produce a fully competent form of the virus. Unmasked cells can present viral antigens to the immune system, that ultimately recognizes and kills such latently infected cells. This review reports and discusses recent studies that have been published on this topic. Copyright © 2018 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.

  3. Relative roles of local disturbance, current climate and palaeoclimate in determining phylogenetic and functional diversity in Chinese forests

    DEFF Research Database (Denmark)

    Feng, Gang; Mi, Xiangcheng; Bøcher, Peder Klith

    2014-01-01

    their relative roles in determining woody plant phylogenetic and functional diversity in this important hotspot for woody plant diversity. Local disturbance was the best predictor of functional diversity as represented by maximum canopy height (Hmax), probably reflecting the dominant role of competition...... studied, their relative importance for other aspects of diversity, notably phylogenetic and functional diversity is so far little studied. Here, we link data from large Chinese forest plots to data on current and Last Glacial Maximum (LGM) climate as well as local disturbance regimes to study...

  4. Triggering of frequent turbidity currents in Monterey Canyon and the role of antecedent conditioning

    Science.gov (United States)

    Clare, M. A.; Rosenberger, K. J.; Talling, P.; Barry, J.; Maier, K. L.; Parsons, D. R.; Simmons, S.; Gales, J. A.; Gwiazda, R.; McGann, M.; Paull, C. K.

    2017-12-01

    Turbidity currents pose a hazard to seafloor infrastructure, deliver organic carbon and nutrients to deep-sea communities, and form economically important deposits. Thus, determining the tempo of turbidity current activity and whether different triggers result in different flow modes is important. Identification of specific triggers is challenging, however, because most studies of turbidity currents are based on their deposits. New direct monitoring of flows and environmental conditions provides the necessary temporal constraints to identify triggering mechanisms. The Coordinated Canyon Experiment (CCE) in Monterey Canyon, offshore California is the most ambitious attempt yet to measure turbidity flows and their triggers. The CCE provides precise constraint on flow timing, initiation, and potential triggers based on measurements at 7 different instrumented moorings and 2 metocean buoys. Fifteen turbidity flows were measured in 18 months; with recorded velocities >8 m/s and run-outs of up to 50 km. Presence of live estuarine foraminifera within moored sediment traps suggests that that flows originated in water depths of Turbidity currents are thought to be triggered by processes including earthquakes, river floods and storm waves. Here we analyse seismicity, local river discharge, internal tides, wave height, direction and period data. We identify no clear control of any of these individual variables on flow timing. None of the recorded earthquakes (

  5. The role of edge current-driven modes in ELM activity

    Energy Technology Data Exchange (ETDEWEB)

    Gimblett, C G; Hastie, R J; Helander, P [EURATOM/UKAEA Fusion Association, Culham Science Centre, Abingdon, Oxon, OX14 3DB (United Kingdom)

    2006-10-15

    We propose a model for edge localized mode (ELM) evolution which goes beyond linear stability arguments by hypothesizing that peeling modes initiate a Taylor relaxation (a constrained minimization of the magnetic energy) of an outer annular plasma region. The relaxation has two effects on peeling mode stability: (a) As the relaxation process proceeds radially inwards it leaves in its wake a Taylor state, which for conventional tokamak ordering is simply a flattened equilibrium toroidal current density. This effect acting in isolation would provide a destabilizing effect (for conventional current profiles the edge current density would increase); (b) The formation of a (negative for conventional current profiles) skin current at the plasma-vacuum interface which has a counteracting stabilizing effect on peeling modes. For a finite relaxed annulus, these two opposing effects can balance and give a configuration that is stable to all possible peeling instabilities. The radial extent of the relaxed region required for stability can be calculated using this balance. This then leads to model predictions for ELM characteristics such as the widths and mode numbers, the magnitude of the attendant energy losses and the natural (deterministic) scatter in these quantities. We compare these model predictions with a number of experimentally observed ELM properties. Further, expanding the governing equations gives analytic expressions for ELM widths in terms of localized edge parameters. Peeling modes can occur even when the critical pressure gradient for the onset of ballooning modes has not been reached. For this reason 'type III' ELMs, which typically occur just above the threshold for L-H transitions, may be best described by this model.

  6. The role of edge current-driven modes in ELM activity

    International Nuclear Information System (INIS)

    Gimblett, C G; Hastie, R J; Helander, P

    2006-01-01

    We propose a model for edge localized mode (ELM) evolution which goes beyond linear stability arguments by hypothesizing that peeling modes initiate a Taylor relaxation (a constrained minimization of the magnetic energy) of an outer annular plasma region. The relaxation has two effects on peeling mode stability: (a) As the relaxation process proceeds radially inwards it leaves in its wake a Taylor state, which for conventional tokamak ordering is simply a flattened equilibrium toroidal current density. This effect acting in isolation would provide a destabilizing effect (for conventional current profiles the edge current density would increase); (b) The formation of a (negative for conventional current profiles) skin current at the plasma-vacuum interface which has a counteracting stabilizing effect on peeling modes. For a finite relaxed annulus, these two opposing effects can balance and give a configuration that is stable to all possible peeling instabilities. The radial extent of the relaxed region required for stability can be calculated using this balance. This then leads to model predictions for ELM characteristics such as the widths and mode numbers, the magnitude of the attendant energy losses and the natural (deterministic) scatter in these quantities. We compare these model predictions with a number of experimentally observed ELM properties. Further, expanding the governing equations gives analytic expressions for ELM widths in terms of localized edge parameters. Peeling modes can occur even when the critical pressure gradient for the onset of ballooning modes has not been reached. For this reason 'type III' ELMs, which typically occur just above the threshold for L-H transitions, may be best described by this model

  7. Vascular manifestations of syndromic aortopathies: role of current and emerging imaging techniques

    International Nuclear Information System (INIS)

    Westerland, O.; Frigiola, A.; Robert, L.; Shaw, A.; Blakeway, L.; Katsanos, K.; Kiesewetter, C.; Chung, N.; Karunanithy, N.

    2015-01-01

    Patients with connective tissue diseases such as Marfan's syndrome, Loeys–Dietz syndrome, and vascular Ehlers–Danlos syndrome comprise a small but important group of patients who present early with acute aortic syndrome comprising aneurysmal dilation, rupture, or aortic dissection. Cardiovascular pathologies are an important yet treatable cause of morbidity and mortality in these patients. Imaging plays an important role in initial diagnosis, surveillance, and identification of complications. Furthermore, these patients are prone to developing complications in other vascular territories. Effective screening and surveillance will allow early diagnosis and elective treatment thus reducing the morbidity and mortality associated with presentation with acute complications. In this article, we will provide an overview of the role of magnetic resonance and computed tomography angiography in the management of syndromic aortopathies.

  8. Current status and emerging role of glutathione in food grade lactic acid bacteria

    OpenAIRE

    Pophaly Sarang; Singh Rameshwar; Pophaly Saurabh; Kaushik Jai K; Tomar Sudhir

    2012-01-01

    Abstract Lactic acid bacteria (LAB) have taken centre stage in perspectives of modern fermented food industry and probiotic based therapeutics. These bacteria encounter various stress conditions during industrial processing or in the gastrointestinal environment. Such conditions are overcome by complex molecular assemblies capable of synthesizing and/or metabolizing molecules that play a specific role in stress adaptation. Thiols are important class of molecules which contribute towards stres...

  9. Core clerkship directors: their current resources and the rewards of the role.

    Science.gov (United States)

    Ephgrave, Kimberly; Margo, Katherine L; White, Christopher; Hammoud, Maya; Brodkey, Amy; Painter, Thomas; Juel, Vern C; Shaw, Darlene; Ferguson, Kristi

    2010-04-01

    To conduct a national multidisciplinary investigation assessing core clinical clerkships and their directors, variances in resources from national guidelines, and the impact of the clerkship director role on faculty members' academic productivity, advancement, and satisfaction. A multidisciplinary working group of the Alliance for Clinical Education (ACE), representing all seven core clinical disciplines, created and distributed a survey to clerkship directors at 125 U.S. MD-granting medical schools, in academic year 2006-2007. A total of 544 clerkship directors from Internal Medicine (96), Family Medicine (91), Psychiatry, (91), Pediatrics (79), Surgery (71), Neurology (60), and Obstetrics-Gynecology (56) responded, representing over 60% of U.S. core clinical clerkships. The clerkship directors were similar across disciplines in demographics and academic productivity, though clinical and clerkship activities varied. Departmental staff support for clerkships averaged 0.69 people, distinctly less than the ACE's 2003 guideline of a full-time coordinator in all disciplines' clerkships. Clerkship directors reported heavy clinical responsibilities, which, as in previous studies, were negatively related to academic productivity. However, many clerkship directors felt the role enhanced their academic advancement; a large majority felt it significantly enhanced their career satisfaction. The resources and rewards of the clerkship director role were similar across disciplines. Expectations of clerkship directors were considerable, including responsibility for clinical material and the learning environment. Resources for many fall short of those stated in the ACE guidelines, particularly regarding support staff. However, the findings indicate that the clerkship director role can have benefits for academic advancement and strongly enhances career satisfaction.

  10. Pioneering a new role: the beginning, current practice and future of the Clinical Nurse Leader.

    Science.gov (United States)

    Poulin-Tabor, Danielle; Quirk, Rebecca L; Wilson, Lauri; Orff, Sonja; Gallant, Paulette; Swan, Nina; Manchester, Nicole

    2008-07-01

    To discuss the development of a new nursing role in response to the health care crisis in the United States. The nursing shortage and fragmentation of care has contributed to the need for nurses who are prepared to laterally integrate care, bring evidence-based practice to the bedside and provide continuity of care to patients and families. The CNLs review the literature, share their experiences, and discuss outcomes related to improved quality of care. Having clinical nurses with a global perspective acting as facilitators and integrators of care is essential to maintaining a high standard of care. Organizational and management support is critical. The more CNLs that can be embedded in an institution, the more successful the role can be. The varied utilization of the CNLs in this practice setting has proven its value in a short period of time and facilitated better communication and collaboration among patients and their health care team. The flexibility and broad scope of this role allows for its use in any practice setting to realize gains in quality outcomes, cost savings, improved patient flow, increased safety, nurse satisfaction and increasing organizational capacity.

  11. Clinical decision making in cancer care: a review of current and future roles of patient age.

    Science.gov (United States)

    Tranvåg, Eirik Joakim; Norheim, Ole Frithjof; Ottersen, Trygve

    2018-05-09

    Patient age is among the most controversial patient characteristics in clinical decision making. In personalized cancer medicine it is important to understand how individual characteristics do affect practice and how to appropriately incorporate such factors into decision making. Some argue that using age in decision making is unethical, and how patient age should guide cancer care is unsettled. This article provides an overview of the use of age in clinical decision making and discusses how age can be relevant in the context of personalized medicine. We conducted a scoping review, searching Pubmed for English references published between 1985 and May 2017. References concerning cancer, with patients above the age of 18 and that discussed age in relation to diagnostic or treatment decisions were included. References that were non-medical or concerning patients below the age of 18, and references that were case reports, ongoing studies or opinion pieces were excluded. Additional references were collected through snowballing and from selected reports, guidelines and articles. Three hundred and forty-seven relevant references were identified. Patient age can have many and diverse roles in clinical decision making: Contextual roles linked to access (age influences how fast patients are referred to specialized care) and incidence (association between increasing age and increasing incidence rates for cancer); patient-relevant roles linked to physiology (age-related changes in drug metabolism) and comorbidity (association between increasing age and increasing number of comorbidities); and roles related to interventions, such as treatment (older patients receive substandard care) and outcome (survival varies by age). Patient age is integrated into cancer care decision making in a range of ways that makes it difficult to claim age-neutrality. Acknowledging this and being more transparent about the use of age in decision making are likely to promote better clinical decisions

  12. Federal Lands

    Data.gov (United States)

    Department of Homeland Security — This map layer consists of federally owned or administered lands of theUnited States, Puerto Rico, and the U.S. Virgin Islands. Only areas of 640 acres or more are...

  13. Current role of antibody therapy in patients with metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Pfeiffer, P; Qvortrup, C; Eriksen, Jesper Grau

    2007-01-01

    progressive disease and unfortunately in patients with disease resistant to 5-fluorouracil/folinic acid, irinotecan and oxaliplatin, no effective cytotoxic therapy is known. The rapidly expanding knowledge in tumor biology has encouraged optimism for the possibility to find and target tumor...... arsenal in CRC to a great extent, but they will also add to the complexity of treatment of CRC. In this review, we summarize the current status of antibody therapy in patients with CRC. Udgivelsesdato: 2007-May-28...

  14. Action potential bursts in central snail neurons elicited by paeonol: roles of ionic currents

    Science.gov (United States)

    Chen, Yi-hung; Lin, Pei-lin; Hsu, Hui-yu; Wu, Ya-ting; Yang, Han-yin; Lu, Dah-yuu; Huang, Shiang-suo; Hsieh, Ching-liang; Lin, Jaung-geng

    2010-01-01

    Aim: To investigate the effects of 2′-hydroxy-4′-methoxyacetophenone (paeonol) on the electrophysiological behavior of a central neuron (right parietal 4; RP4) of the giant African snail (Achatina fulica Ferussac). Methods: Intracellular recordings and the two-electrode voltage clamp method were used to study the effects of paeonol on the RP4 neuron. Results: The RP4 neuron generated spontaneous action potentials. Bath application of paeonol at a concentration of ≥500 μmol/L reversibly elicited action potential bursts in a concentration-dependent manner. Immersing the neurons in Co2+-substituted Ca2+-free solution did not block paeonol-elicited bursting. Pretreatment with the protein kinase A (PKA) inhibitor KT-5720 or the protein kinase C (PKC) inhibitor Ro 31-8220 did not affect the action potential bursts. Voltage-clamp studies revealed that paeonol at a concentration of 500 μmol/L had no remarkable effects on the total inward currents, whereas paeonol decreased the delayed rectifying K+ current (IKD) and the fast-inactivating K+ current (IA). Application of 4-aminopyridine (4-AP 5 mmol/L), an inhibitor of IA, or charybdotoxin 250 nmol/L, an inhibitor of the Ca2+-activated K+ current (IK(Ca)), failed to elicit action potential bursts, whereas tetraethylammonium chloride (TEA 50 mmol/L), an IKD blocker, successfully elicited action potential bursts. At a lower concentration of 5 mmol/L, TEA facilitated the induction of action potential bursts elicited by paeonol. Conclusion: Paeonol elicited a bursting firing pattern of action potentials in the RP4 neuron and this activity relates closely to the inhibitory effects of paeonol on the IKD. PMID:21042287

  15. Current role of non-anesthesiologist administered propofol sedation in advanced interventional endoscopy

    DEFF Research Database (Denmark)

    Burtea, Daniela Elena; Dimitriu, Anca; Maloş, Anca Elena

    2015-01-01

    the patients and medical personnel. Current guidelines support the use of propofol sedation, which has the same rate of adverse effects as traditional sedation with benzodiazepines and/or opioids, but decreases the procedural and recovery time. Non-anesthesiologist administered propofol sedation has become......, improved satisfaction for patients and doctors, as well as decreased recovery and discharge time. Despite the advantages of non-anesthesiologist administered propofol, there is still a continuous debate related to the successful generalization of the procedures....

  16. Role of spin diffusion in current-induced domain wall motion for disordered ferromagnets

    KAUST Repository

    Akosa, Collins Ashu; Kim, Won-Seok; Bisig, André ; Klä ui, Mathias; Lee, Kyung-Jin; Manchon, Aurelien

    2015-01-01

    Current-induced spin transfer torque and magnetization dynamics in the presence of spin diffusion in disordered magnetic textures is studied theoretically. We demonstrate using tight-binding calculations that weak, spin-conserving impurity scattering dramatically enhances the nonadiabaticity. To further explore this mechanism, a phenomenological drift-diffusion model for incoherent spin transport is investigated. We show that incoherent spin diffusion indeed produces an additional spatially dependent torque of the form ∼∇2[m×(u⋅∇)m]+ξ∇2[(u⋅∇)m], where m is the local magnetization direction, u is the direction of injected current, and ξ is a parameter characterizing the spin dynamics (precession, dephasing, and spin-flip). This torque, which scales as the inverse square of the domain wall width, only weakly enhances the longitudinal velocity of a transverse domain wall but significantly enhances the transverse velocity of vortex walls. The spatial-dependent spin transfer torque uncovered in this study is expected to have significant impact on the current-driven motion of abrupt two-dimensional textures such as vortices, skyrmions, and merons.

  17. Role of spin diffusion in current-induced domain wall motion for disordered ferromagnets

    KAUST Repository

    Akosa, Collins Ashu

    2015-03-12

    Current-induced spin transfer torque and magnetization dynamics in the presence of spin diffusion in disordered magnetic textures is studied theoretically. We demonstrate using tight-binding calculations that weak, spin-conserving impurity scattering dramatically enhances the nonadiabaticity. To further explore this mechanism, a phenomenological drift-diffusion model for incoherent spin transport is investigated. We show that incoherent spin diffusion indeed produces an additional spatially dependent torque of the form ∼∇2[m×(u⋅∇)m]+ξ∇2[(u⋅∇)m], where m is the local magnetization direction, u is the direction of injected current, and ξ is a parameter characterizing the spin dynamics (precession, dephasing, and spin-flip). This torque, which scales as the inverse square of the domain wall width, only weakly enhances the longitudinal velocity of a transverse domain wall but significantly enhances the transverse velocity of vortex walls. The spatial-dependent spin transfer torque uncovered in this study is expected to have significant impact on the current-driven motion of abrupt two-dimensional textures such as vortices, skyrmions, and merons.

  18. The Current Role of Venous Sampling in the Localization of Endocrine Disease

    International Nuclear Information System (INIS)

    Lau, Jeshen H. G.; Drake, William; Matson, Matthew

    2007-01-01

    Endocrine venous sampling plays a specific role in the diagnosis of endocrine disorders. In this article, we cover inferior petrosal sinus sampling, selective parathyroid venous sampling, hepatic venous sampling with arterial stimulation, adrenal venous sampling, and ovarian venous sampling. We review their indications and the scientific evidence justifying these indications in the diagnosis and management of Cushing's syndrome, hyperparathyroidism, pancreatic endocrine tumors, Conn's syndrome, primary hyperaldosteronism, pheochromocytomas, and androgen-secreting ovarian tumors. For each sampling technique, we compare its diagnostic accuracy with that of other imaging techniques and, where possible, look at how it impacts patient management. Finally, we incorporate venous sampling into diagnostic algorithms used at our institution

  19. The Role of Clinical Cardiac Magnetic Resonance Imaging in China: Current Status and the Future

    Directory of Open Access Journals (Sweden)

    Shi Chen, MD

    2016-12-01

    Full Text Available Cardiac magnetic resonance (CMR imaging plays an important role in the diagnosis and management of cardiovascular diseases. The state-of-the-art CMR imaging has many advantages in cardiac imaging, including excellent spatial and temporal resolution, unrestricted imaging field, no exposure to ionizing radiation, excellent tissue contrast, and unique myocardial tissue characterization. Clinical CMR imaging is used during the cardiovascular diagnostic workup in the United States and some European countries. Use of CMR imaging is emerging in hospitals in China and has a promising future. This review briefly describes the real-world clinical application of CMR imaging in China and discuss obstacles for its future development.

  20. "Our federalism" moves indoors.

    Science.gov (United States)

    Ruger, Theodore W

    2013-04-01

    A great deal of the US Supreme Court's federalism jurisprudence over the past two decades has focused on the outer limits of federal power, suggesting a mutually exclusive division of jurisdiction between the states and the federal government, where subjects are regulated by one sovereign or the other but not both. This is not an accurate picture of American governance as it has operated over the past half century - most important areas of American life are regulated concurrently by both the federal government and the states. The Supreme Court's June 2012 decision clearing the way for the Patient Protection and Affordable Care Act (PPACA) to move forward thus should not be regarded as an affront to state sovereignty but as a realistic embrace of state power in its active, modern form. The PPACA is infused with multiple major roles for the states, and as the statute goes into operation over the next few years, states retain, and are already exercising, substantial policy discretion.

  1. Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors

    Directory of Open Access Journals (Sweden)

    Gregory eBeaudet

    2015-01-01

    Full Text Available Elderly persons often face biological, psychological or social changes over time that may cause discomfort or morbidity. While some cognitive domains remain stable over time, others undergo a decline. Spatial navigation is a complex cognitive function essential for independence, safety and quality of life. While egocentric (body-centered navigation is quite preserved during aging, allocentric (externally-centered navigation — based on a cognitive map using distant landmarks — declines with age. Recent preclinical studies showed that serotonergic 5-HT7 receptors are localized in brain regions associated with allocentric spatial navigation processing. Behavioral assessments with pharmacological or genetic tools have confirmed the role of 5-HT7 receptors in allocentric navigation. Moreover, few data suggested a selective age-related decrease in the expression of 5-HT7 receptors in pivotal brain structures implicated in allocentric navigation such as the hippocampal CA3 region. We aim to provide a short overview of the potential role of 5-HT7 receptors in spatial navigation, and to argue for their interests as therapeutic targets against age-related cognitive decline.

  2. The Emerging Role of Tractography in Deep Brain Stimulation: Basic Principles and Current Applications

    Directory of Open Access Journals (Sweden)

    Nelson B. Rodrigues

    2018-01-01

    Full Text Available Diffusion tensor imaging (DTI is an MRI-based technique that delineates white matter tracts in the brain by tracking the diffusion of water in neural tissue. This methodology, known as “tractography”, has been extensively applied in clinical neuroscience to explore nervous system architecture and diseases. More recently, tractography has been used to assist with neurosurgical targeting in functional neurosurgery. This review provides an overview of DTI principles, and discusses current applications of tractography for improving and helping develop novel deep brain stimulation (DBS targets.

  3. Role of imaging in testicular cancer: current and future practice.

    Science.gov (United States)

    Barrisford, Glen W; Kreydin, Evgeniy I; Preston, Mark A; Rodriguez, Dayron; Harisighani, Mukesh G; Feldman, Adam S

    2015-09-01

    The article provides a summary of the epidemiologic and clinical aspects of testicular malignancy. Current standard imaging and novel techniques are reviewed. Present data and clinical treatment trends have favored surveillance protocols over adjuvant radiation or chemotherapy for low-stage testicular malignancy. This has resulted in increasing numbers of imaging studies and the potential for increased long-term exposure risks. Understanding imaging associated risks as well as strategies to minimize these risks is of increasing importance. The development, validation and incorporation of alternative lower risk highly efficacious and cost-effective imaging techniques is essential.

  4. The Role of Ionospheric O+ in Forming the Storm-time Ring Current

    Science.gov (United States)

    Kistler, L. M.; Mouikis, C.; Menz, A.; Bingham, S.

    2017-12-01

    During storm times, the particle pressure that creates the storm-time ring current in the inner magnetosphere can be dominated by O+. This is surprising, as the immediate source for the ring current is the nightside plasma sheet, and O+ is usually not the dominant species in the plasma sheet. In this talk we examine the many factors that lead to this result. The O+ outflow is enhanced during geomagnetically active times. The transport paths of O+ and H+ are different, such that the O+ that reaches the near-earth plasma sheet is more energetic than H+. The source spectrum in the near-earth plasma sheet can be harder for O+ than for H+, perhaps due to substorm injections, so that the more energetic plasma has a higher O+/H+ ratio. And finally the plasma sheet O+ can be more abundant towards the beginning of the storm, when the convection is largest, so the enhanced O+ is brought the deepest into the inner magnetosphere. We will discuss the interrelationships between these different effects as well as the ways in which O+ itself may influence the system.

  5. The role of stents in the treatment of congenital heart disease: Current status and future perspectives

    International Nuclear Information System (INIS)

    Peters, Bjoern; Ewert, Peter; Berger, Felix

    2009-01-01

    Intravascular or intracardiac stenoses occur in many forms of congenital heart disease (CHD). Therefore, the implantation of stents has become an accepted interventional procedure for stenotic lesions in pediatric cardiology. Furthermore, stents are know to be used to exclude vessel aneurysm or to ensure patency of existing or newly created intracardiac communications. With the further refinement of the first generation of devices, a variety of “modern” stents with different design characteristics have evolved. Despite the tremendous technical improvement over the last 20 years, the “ideal stent” has not yet been developed. Therefore, the pediatric interventionalist has to decide which stent is suitable for each lesion. On this basis, currently available stents are discussed in regard to their advantages and disadvantages for common application in CHD. New concepts and designs developed to overcome some of the existing problems, like the failure of adaptation to somatic growth, are presented. Thus, in the future, biodegradable or growth stents might replace the currently used generation of stents. This might truly lead to widening indications for the use of stents in the treatment of CHD

  6. Current role of liquid chromatography coupled to mass spectrometry in clinical toxicology screening methods.

    Science.gov (United States)

    Viette, Véronique; Fathi, Marc; Rudaz, Serge; Hochstrasser, Denis; Veuthey, Jean-Luc

    2011-07-01

    Abstract Toxicological screening is the analysis of a biological specimen to detect and identify compounds in patients admitted to the hospital with acute intoxication of unknown origin. The screening of a wide range of toxicologically relevant compounds in biological samples is a serious challenge for clinical laboratories. The high selectivity and sensitivity of liquid chromatography coupled to mass spectrometry or tandem mass spectrometry technology provides an attractive alternative to the current methods. For these reasons, an increasing number of applications for multi-target screening or general screening of unknown compounds in biological matrices are being published. This paper is an overview of sample clean-up, chromatographic separation and mass spectrometry detection procedures which can be combined to obtain screening methods adapted to the constraints and needs of various laboratories, and none specifically in clinical toxicology. Currently the techniques are in the hands of specialists, principally in academic institutes. However, the evolution in technology should allow application of the techniques as a tool in toxicology laboratories and thus more widespread exploitation of their potential.

  7. The role of ultrasound elastographic techniques in chronic liver disease: Current status and future perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Piscaglia, Fabio, E-mail: fabio.piscaglia@unibo.it [Division of Internal Medicine, University of Bologna, General and University Hospital S. Orsola-Malpighi, Bologna (Italy); Marinelli, Sara, E-mail: sara_marinelli@libero.it [Division of Internal Medicine, University of Bologna, General and University Hospital S. Orsola-Malpighi, Bologna (Italy); Bota, Simona, E-mail: bota_simona1982@yahoo.com [Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara (Romania); Serra, Carla, E-mail: carla.serra@aosp.bo.it [Division of Medical Liver Transplant Care, General and University Hospital S. Orsola-Malpighi, Bologna (Italy); Venerandi, Laura, E-mail: laura.venerandi@gmail.com [Division of Internal Medicine, University of Bologna, General and University Hospital S. Orsola-Malpighi, Bologna (Italy); Leoni, Simona, E-mail: leonisimona@yahoo.it [Division of Internal Medicine, University of Bologna, General and University Hospital S. Orsola-Malpighi, Bologna (Italy); Salvatore, Veronica, E-mail: veronica.salvatore@unibo.it [Division of Internal Medicine, University of Bologna, General and University Hospital S. Orsola-Malpighi, Bologna (Italy)

    2014-03-15

    This review illustrates the state of the art clinical applications and the future perspectives of ultrasound elastographic methods for the evaluation of chronic liver diseases, including the most widely used and validated technique, transient elastography, followed by shear wave elastography and strain imaging elastography. Liver ultrasound elastography allows the non-invasive evaluation of liver stiffness, providing information regarding the stage of fibrosis, comparable to liver biopsy which is still considered the gold standard; in this way, it can help physicians in managing patients, including the decision as to when to start antiviral treatment. The characterization of focal liver lesions and the prognostic role of the elastographic technique in the prediction of complications of cirrhosis are still under investigation.

  8. Role of Plants in a Constructed Wetland: Current and New Perspectives

    Directory of Open Access Journals (Sweden)

    Amit Gross

    2013-04-01

    Full Text Available The role of plants in the treatment of effluents by constructed wetland (CW systems is under debate. Here, we review ways in which plants can affect CW processes and suggest two novel functions for plants in CWs. The first is salt phytoremediation by halophytes. We have strong evidence that halophytic plants can reduce wastewater salinity by accumulating salts in their tissues. Our studies have shown that Bassia indica, a halophytic annual, is capable of salt phytoremediation, accumulating sodium to up to 10% of its dry weight. The second novel use of plants in CWs is as phytoindicators of water quality. We demonstrate that accumulation of H2O2, a marker for plant stress, is reduced in the in successive treatment stages, where water quality is improved. It is recommended that monitoring and management of CWs consider the potential of plants as phytoremediators and phytoindicators.

  9. Exploring Current and Future Roles of Non-Dental Professionals: Implications for Dental Hygiene Education.

    Science.gov (United States)

    Maxey, Hannah L; Farrell, Christine; Gwozdek, Anne

    2017-09-01

    The health care system is undergoing transformation in which oral health is not only valued as an aspect of overall health, but health care delivery systems are aligning to better deliver total patient care. As a result of this transformation, education for many non-dental professionals incorporates oral health content to prepare them to practice in comprehensive delivery models. While some non-dental professionals already incorporate oral health care in their service, many opportunities exist for expansion of oral health care delivery by other non-dental professionals, including radiologic technicians, nursing staff, and human services professionals. As non-dental professionals take on expanded roles in oral health care, the dental hygiene workforce must be prepared to practice in settings with new types of professionals. Dental hygiene curricula should prioritize interprofessional education to best prepare these students for practice in evolved delivery models. This article was written as part of the project "Advancing Dental Education in the 21 st Century."

  10. Androgens and the male reproductive tract: an overview of classical roles and current perspectives.

    Science.gov (United States)

    Patrão, Marilia T C C; Silva, Erick J R; Avellar, Maria Christina W

    2009-11-01

    Androgens are steroid hormones that play key roles in the development and maintenance of male phenotype and reproductive function. These hormones also affect the function of several non-reproductive organs, such as bone and skeletal muscle. Endogenous androgens exert most of their effects by genomic mechanisms, which involve hormone binding to the androgen receptor (AR), a ligand-activated transcription factor, resulting in the modulation of gene expression. AR-induced non-genomic mechanisms have also been reported. A large number of steroidal and non-steroidal AR-ligands have been developed for therapeutic use, including the treatment of male hypogonadism (AR agonists) and prostate diseases (AR antagonists), among other pathological conditions. Here, the AR gene and protein structure, mechanism of action and AR gene homologous regulation were reviewed. The AR expression pattern, its in vivo regulation and physiological relevance in the developing and adult testis and epididymis, which are sites of sperm production and maturation, respectively, were also presented.

  11. Role of genetics in the etiopathogenesis of genetic generalized epilepsy: A review of current literature

    Directory of Open Access Journals (Sweden)

    S A Balarabe

    2016-01-01

    Full Text Available Until recently, genetic generalized epilepsy (GGE was believed to be of presumed genetic etiology with no identifiable genetic mutation or demonstrable epigenetic abnormality. A wide range of epileptic disorders has clue for an inherited susceptibility. Monogenic disorders associated with epilepsy mental retardation and structural brain lesion typified by heterotopias, tuberous sclerosis, and progressive myoclonus epilepsies account for about 1% of epilepsies. This review focuses on the role of genetic mutations and epigenetic rearrangements in the pathophysiologic mechanism of GGE. To achieve this; PubMed, EMBASE, and Google Scholar were systematically and comprehensively searched using keywords (“epilepsy” “juvenile myoclonic epilepsy (JME,” “typical absences,” “idiopathic generalized epilepsy,” “JME,” “juvenile absence epilepsy,” “childhood absence epilepsy” “generalized tonic-clonic seizure” “GTCS”. Most GGE has evidence of underlying genetic inheritance. Recent animal studies have shown that early detection and treatment of genetic generalized epilepsies can alter the phenotypic presentation in rodents. These findings suggest a critical period in epileptogenesis, during which spike-and-wave seizures can be suppressed, leading to chronic changes in the brain (epileptogenesis and the preceding dysfunctions may, therefore, be targeted using therapeutic approaches that may either delay or inhibit the transition to active epileptic attack. The interplay between genetic mutations and epigenetic rearrangements play important roles in the development of GCE and that this process, especially at crucial developmental periods, is very susceptible to environmental modulations.

  12. The role of business in addressing the long-term implications of the current food crisis

    Directory of Open Access Journals (Sweden)

    Yach Derek

    2008-12-01

    Full Text Available Abstract Before the onset of the current food crisis, the evidence of a severely neglected nutrition crisis was starting to receive attention. Increased food prices are having severe impacts on the nutritional status of populations. Our current food system has evolved over decades in a largely unplanned manner and without consideration for the complexity and implications of linkages between health, nutrition, agricultural, economic, trade and security issues. The underlying causes for the nutrition crisis include the above, as well as decades of neglect with regard to nutrition, and agricultural science (especially in emerging markets; a failure of governance with respect to the major players involved in nutrition, a weak response by government donors and Foundations to invest in basic nutrition (in contrast to growing support for humanitarian aspects of food aid, and a reluctance to develop private-public partnerships. The emergence of new business models that tackle social problems while remaining profitable offers promise that the long term nutrition needs of people can be met. Businesses can have greater impact acting collectively than individually. Food, retail, food service, chemical and pharmaceutical companies have expertise, distribution systems and customers insights, if well harnessed, could leapfrog progress in addressing the food and nutrition crises. While business can do lots more, its combined impact will be minimal if a range of essential government actions and policies are not addressed. Governments need to create innovative and complementary opportunities that include incentives for businesses including: setting clear nutritional guidelines for fortification and for ready-to eat products; offering agreements to endorse approved products and support their distribution to clinics and schools; eliminating duties on imported vitamins and other micronutrients; and providing tax and other incentives for industry to invest with

  13. The role of business in addressing the long-term implications of the current food crisis.

    Science.gov (United States)

    Yach, Derek

    2008-12-05

    Before the onset of the current food crisis, the evidence of a severely neglected nutrition crisis was starting to receive attention. Increased food prices are having severe impacts on the nutritional status of populations. Our current food system has evolved over decades in a largely unplanned manner and without consideration for the complexity and implications of linkages between health, nutrition, agricultural, economic, trade and security issues. The underlying causes for the nutrition crisis include the above, as well as decades of neglect with regard to nutrition, and agricultural science (especially in emerging markets); a failure of governance with respect to the major players involved in nutrition, a weak response by government donors and Foundations to invest in basic nutrition (in contrast to growing support for humanitarian aspects of food aid), and a reluctance to develop private-public partnerships. The emergence of new business models that tackle social problems while remaining profitable offers promise that the long term nutrition needs of people can be met. Businesses can have greater impact acting collectively than individually. Food, retail, food service, chemical and pharmaceutical companies have expertise, distribution systems and customers insights, if well harnessed, could leapfrog progress in addressing the food and nutrition crises. While business can do lots more, its combined impact will be minimal if a range of essential government actions and policies are not addressed. Governments need to create innovative and complementary opportunities that include incentives for businesses including: setting clear nutritional guidelines for fortification and for ready-to eat products; offering agreements to endorse approved products and support their distribution to clinics and schools; eliminating duties on imported vitamins and other micronutrients; and providing tax and other incentives for industry to invest with donors in essential nutrition

  14. Current rectification in a single molecule diode: the role of electrode coupling.

    Science.gov (United States)

    Sherif, Siya; Rubio-Bollinger, Gabino; Pinilla-Cienfuegos, Elena; Coronado, Eugenio; Cuevas, Juan Carlos; Agraït, Nicolás

    2015-07-24

    We demonstrate large rectification ratios (> 100) in single-molecule junctions based on a metal-oxide cluster (polyoxometalate), using a scanning tunneling microscope (STM) both at ambient conditions and at low temperature. These rectification ratios are the largest ever observed in a single-molecule junction, and in addition these junctions sustain current densities larger than 10(5) A cm(-2). By following the variation of the I-V characteristics with tip-molecule separation we demonstrate unambiguously that rectification is due to asymmetric coupling to the electrodes of a molecule with an asymmetric level structure. This mechanism can be implemented in other type of molecular junctions using both organic and inorganic molecules and provides a simple strategy for the rational design of molecular diodes.

  15. The role of alternating current in photo-assisted electrochemical porosification of GaN

    International Nuclear Information System (INIS)

    Ainorkhilah, Mahmood; Naser, M. Ahmed; Yushamdan, Yusof; Kwong, Yam Fong; Zainuriah, Hassan; Tiginyanu, Ion; Siang, Chuah Lee

    2013-01-01

    In this paper, we report the formation of porous GaN films under a novel alternating current (sine-wave a.c. (50 Hz)) photo-assisted electrochemical (ACPEC) etching conditions. The ACPEC formed porous GaN with excellent structural and surface morphology. Field emission scanning electron microscope (FESEM), atomic force microscopy (AFM) and high resolution X-ray diffraction (HR-XRD) phi-scan and rocking curves measurements evidenced important features of the pore morphology and nanostructures. According to the FESEM micrographs, the spatial nano architecture of the porous structures exhibits pores with perfect hexagonal shape. The AFM measurements revealed an increase in the surface roughness induced by porosification. X-ray diffraction phi-scan showed that porous GaN sample maintained the epitaxial. (authors)

  16. Current Roles and Future Applications of Cardiac CT: Risk Stratification of Coronary Artery Disease

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Yeonyee Elizabeth [Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam 463-707 (Korea, Republic of); Lim, Tae-Hwan [Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736 (Korea, Republic of)

    2014-07-01

    Cardiac computed tomography (CT) has emerged as a noninvasive modality for the assessment of coronary artery disease (CAD), and has been rapidly integrated into clinical cares. CT has changed the traditional risk stratification based on clinical risk to image-based identification of patient risk. Cardiac CT, including coronary artery calcium score and coronary CT angiography, can provide prognostic information and is expected to improve risk stratification of CAD. Currently used conventional cardiac CT, provides accurate anatomic information but not functional significance of CAD, and it may not be sufficient to guide treatments such as revascularization. Recently, myocardial CT perfusion imaging, intracoronary luminal attenuation gradient, and CT-derived computed fractional flow reserve were developed to combine anatomical and functional data. Although at present, the diagnostic and prognostic value of these novel technologies needs to be evaluated further, it is expected that all-in-one cardiac CT can guide treatment and improve patient outcomes in the near future.

  17. The role of hybrid SPECT-CT in oncology: current and emerging clinical applications

    International Nuclear Information System (INIS)

    Chowdhury, F.U.; Scarsbrook, A.F.

    2008-01-01

    Single photon emission computed tomography - computed tomography (SPECT-CT) is an emerging dual-modality imaging technique with many established and potential clinical applications in the field of oncology. To date, there has been a considerable emphasis on the benefits of integrated positron emission tomography - computed tomography (PET-CT) in oncology, but relatively little focus on the clinical utility of SPECT-CT. As with PET-CT, accurate co-registration of anatomical and functional data from a combined SPECT-CT camera often provides complementary diagnostic information. Both sensitivity (superior disease localization) and specificity (exclusion of false-positives due to physiological tracer uptake) are improved, and the functional significance of indeterminate lesions detected on cross-sectional imaging can be defined. This article will review the scope of hybrid SPECT-CT in oncology and illustrate both current and emerging clinical applications

  18. The current role of on-line extraction approaches in clinical and forensic toxicology.

    Science.gov (United States)

    Mueller, Daniel M

    2014-08-01

    In today's clinical and forensic toxicological laboratories, automation is of interest because of its ability to optimize processes, to reduce manual workload and handling errors and to minimize exposition to potentially infectious samples. Extraction is usually the most time-consuming step; therefore, automation of this step is reasonable. Currently, from the field of clinical and forensic toxicology, methods using the following on-line extraction techniques have been published: on-line solid-phase extraction, turbulent flow chromatography, solid-phase microextraction, microextraction by packed sorbent, single-drop microextraction and on-line desorption of dried blood spots. Most of these published methods are either single-analyte or multicomponent procedures; methods intended for systematic toxicological analysis are relatively scarce. However, the use of on-line extraction will certainly increase in the near future.

  19. Current controversies on the role of behavior therapy in Tourette Syndrome

    Science.gov (United States)

    Scahill, Lawrence; Woods, Douglas W.; Himle, Michael B.; Peterson, Alan L.; Wilhelm, Sabine; Piacentini, John C.; McNaught, Kevin; Walkup, John T.; Mink, Jonathan W.

    2014-01-01

    Comprehensive Behavioral Intervention for Tics (CBIT) is a safe and effective treatment for managing the tics of TS. In contrast to most current medications used for the treatment of tics, the efficacy of CBIT has been demonstrated in two relatively large, multisite trials. It also shows durability of benefit over time. Similar to psychopharmacological intervention, skilled practitioners are required to implement the intervention. Despite concerns about the effort required to participate in CBIT, patients with TS and parents of children with TS appear willing to meet the requirements of the CBIT program. Efforts are underway to increase the number of trained CBIT providers in the United States. Based on available evidence, recent published guidelines suggest that CBIT can be considered a first-line treatment for persons with a tic disorders. PMID:23681719

  20. The role of augmentative and alternative communication for children with autism: current status and future trends

    Directory of Open Access Journals (Sweden)

    Iacono T

    2016-09-01

    Full Text Available Teresa Iacono,1 David Trembath,2 Shane Erickson3 1Living with Disability Research Centre, La Trobe University, Bendigo, VIC, Australia; 2Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia; 3Living with Disability Research Centre, La Trobe University, Melbourne, VIC, Australia Background: Augmentative and alternative communication (AAC interventions are used for children with autism, often as stand-alone communication interventions for those who are minimally verbal. Our aim was to synthesize the evidence for AAC interventions for children (up to 21 years, and then consider the role of AAC within established, comprehensive, evidence-based autism interventions targeting learning across multiple developmental domains.Design: We completed a systematic search of three databases (OVID Medline, PsycINFO, ERIC as well as forward citation and hand searches to identify systematic reviews of AAC intervention efficacy research including children with autism, published between 2000 and March 2016 in peer-reviewed journals. Data pertaining to the quality indicators of included studies, effect sizes for intervention outcomes, and evidence for effectiveness were extracted for descriptive analysis.Results: The search yielded 17 systematic reviews. Most provided indicators of research quality for included studies, of which only relatively few provided conclusive results. Communication targets tended to be focused on teaching children to make requests. Still, effect size measures for included studies indicated that AAC was effective to highly effective.Conclusion: There is growing evidence for the potential benefits of AAC for children with autism, but there is a need for more well-designed studies and broader, targeted outcomes. Furthermore, a lack of evidence for the role of AAC within comprehensive intervention programs may account for a tendency by autism researchers and practitioners to neglect this intervention. Attempts to

  1. IRM in the Federal Government: Opinions and Reflections.

    Science.gov (United States)

    Haney, Glenn P.

    1989-01-01

    Evaluates various aspects of federal information resources management and reviews technological changes within the Department of Agriculture to illustrate current issues and future trends in information resources management. Topics discussed include telecommunications and networking; distributed processing and field office automation; the role of…

  2. Current role of the radiographers in imaging diagnostics, nuclear medicine and radiotherapy in modern departments

    International Nuclear Information System (INIS)

    Karidova, S.; Velkova, K.; Panamska, K.; Petkova, K.

    2006-01-01

    Full text: In the communication we set out to focus the attention of the medical staff and the public on the place and the constantly growing role (relative burden) of the radiographers in imaging diagnostics, nuclear medicine and radiotherapy in the field of modern medicine. The advanced radiographers level and rapid development of the contemporary equipment and apparatuses used in imaging diagnostics, nuclear medicine and radiotherapy, as well as the methods of their utilization, presuppose very good and constantly improving theoretical and practical training of the imaging technician. The radiographer fulfills responsible tasks under the guidance of the physician or independently and bears specific responsibilities. Having mastered the fundamentals of radiation protection, the imaging technician protects both himself and the patient from the impact of ionizing radiation. To be able to fulfill his/her constantly increasing duties and obligations, the imaging radiographer has acquired wide knowledge of general education subjects, subjects of general medicine and special subjects. The radiographer has a good knowledge of Latin and a modern foreign language, and he is also computer literate so as to be able to cope with the widely spread visualizing methods. The radiographer acquires additional post-graduate training to work in narrowly specialized fields as well as to improve his/her qualifications

  3. Role of the pH in state-dependent blockade of hERG currents

    Science.gov (United States)

    Wang, Yibo; Guo, Jiqing; Perissinotti, Laura L.; Lees-Miller, James; Teng, Guoqi; Durdagi, Serdar; Duff, Henry J.; Noskov, Sergei Yu.

    2016-10-01

    Mutations that reduce inactivation of the voltage-gated Kv11.1 potassium channel (hERG) reduce binding for a number of blockers. State specific block of the inactivated state of hERG block may increase risks of drug-induced Torsade de pointes. In this study, molecular simulations of dofetilide binding to the previously developed and experimentally validated models of the hERG channel in open and open-inactivated states were combined with voltage-clamp experiments to unravel the mechanism(s) of state-dependent blockade. The computations of the free energy profiles associated with the drug block to its binding pocket in the intra-cavitary site display startling differences in the open and open-inactivated states of the channel. It was also found that drug ionization may play a crucial role in preferential targeting to the open-inactivated state of the pore domain. pH-dependent hERG blockade by dofetilie was studied with patch-clamp recordings. The results show that low pH increases the extent and speed of drug-induced block. Both experimental and computational findings indicate that binding to the open-inactivated state is of key importance to our understanding of the dofetilide’s mode of action.

  4. Role of ultrasound for central catheter tip localization in neonates: a review of the current evidence.

    Science.gov (United States)

    Sharma, Deepak; Farahbakhsh, Nazanin; Tabatabaii, Seyyed Ahmad

    2018-02-15

    Central catheters are known as "life lines" in intensive care units and are used frequently in neonatal intensive care unit (NICU) for multiple indications. The central catheters used in NICU includes umbilical venous catheter (UVC), umbilical arterial catheter (UAC) and peripherally inserted central catheter (PICC) lines. The tip of these central lines needs to be in a correct position as malpositioned central line tips lead to many neonatal complications. Radiograph either abdomen or chest is the most widely used modality for locating the tip of the central catheter. There are many disadvantages of radiographic confirmation of tip position and recently ultrasound (USG)/echocardiography has been used for localization of catheter tip. USG provides real-time assessment of the tip position with other added advantages like no radiation exposure, need for minimal training for performing USG, minimal handling of the neonate, identification of migration of central lines and making repositioning of central lines under USG guidance. The present evidence supports the use of USG/Echo for localization of central catheter tip and USG has shown to have good sensitivity, specificity, positive predictive value and negative predictive value when compared with a radiograph. In this review, we discuss about the role of USG/Echo in the identification of tip of central catheters in neonatal care.

  5. The current role of Gamma Knife radiosurgery in the management of intracranial haemangiopericytoma.

    Science.gov (United States)

    Spina, Alfio; Boari, Nicola; Gagliardi, Filippo; Donofrio, Carmine A; Franzin, Alberto; Mortini, Pietro

    2016-04-01

    Haemangiopericytomas (HPCs) are rare tumours characterised by aggressive behaviour with tendency to local recurrence and to metastasise. WHO grade II and grade III tumours show different progression-free survival and overall survival rates. Gross total tumour resection is still considered the treatment of choice. Adjuvant radiation therapies represent an option in the treatment strategy regardless the extent of resection. Based on this consideration, Gamma Knife radiosurgery has been introduced either as a primary treatment or as an adjuvant treatment for residual or recurrent tumours. A systematic search was performed on PubMed, Web of Science and Google Scholar for clinical series reporting Gamma Knife radiosurgery, Cyberknife and Linear Accelerator (LINAC) for the management of intracranial HPCs. Fourteen studies focusing on the effects of Gamma Knife radiosurgery for intracranial HPCs were included. Four studies reported data on Cyberknife radiosurgery and LINAC. A total of 208 patients harbouring 366 tumours have been reported. Patient's features, radiosurgical treatment characteristics and follow-up data of the pertinent literature have been critically revised. Gamma Knife radiosurgery and the other radiosurgical techniques represent a feasible and effective therapy in the management of HPCs. Tumour control and survival rate are comparable to those reported for radiotherapy. Further studies should be focused to define the exact role of Gamma Knife radiosurgery in the management of HPCs.

  6. Role of Helicobacter pylori infection in gastric carcinogenesis: Current knowledge and future directions

    Science.gov (United States)

    Sokic-Milutinovic, Aleksandra; Alempijevic, Tamara; Milosavljevic, Tomica

    2015-01-01

    Helicobacter pylori (H. pylori) plays a role in the pathogenesis of gastric cancer. The outcome of the infection depends on environmental factors and bacterial and host characteristics. Gastric carcinogenesis is a multistep process that is reversible in the early phase of mucosal damage, but the exact point of no return has not been identified. Therefore, two main therapeutic strategies could reduce gastric cancer incidence: (1) eradication of the already present infection; and (2) immunization (prior to or during the course of the infection). The success of a gastric cancer prevention strategy depends on timing because the prevention strategy must be introduced before the point of no return in gastric carcinogenesis. Although the exact point of no return has not been identified, infection should be eradicated before severe atrophy of the gastric mucosa develops. Eradication therapy rates remain suboptimal due to increasing H. pylori resistance to antibiotics and patient noncompliance. Vaccination against H. pylori would reduce the cost of eradication therapies and lower gastric cancer incidence. A vaccine against H. pylori is still a research challenge. An effective vaccine should have an adequate route of delivery, appropriate bacterial antigens and effective and safe adjuvants. Future research should focus on the development of rescue eradication therapy protocols until an efficacious vaccine against the bacterium becomes available. PMID:26556993

  7. Doctors as managers of healthcare resources in Nigeria: Evolving roles and current challenges.

    Science.gov (United States)

    Ojo, Temitope Olumuyiwa; Akinwumi, Adebowale Femi

    2015-01-01

    Over the years, medical practice in Nigeria has evolved in scope and practice, in terms of changing disease patterns, patients' needs, and social expectations. In addition, there is a growing sentiment especially among the general public and some health workers that most doctors are bad managers. Besides drawing examples from some doctors in top management positions that have performed less creditably, critics also harp on the fact that more needs to be done to improve the training of doctors in health management. This article describes the role of doctors in this changing scene of practice and highlights the core areas where doctors' managerial competencies are required to improve the quality of healthcare delivery. Areas such as health care financing, essential drugs and supplies management, and human resource management are emphasized. Resources to be managed and various skills needed to function effectively at the different levels of management are also discussed. To ensure that doctors are well-skilled in managerial competencies, the article concludes by suggesting a curriculum review at undergraduate and postgraduate levels of medical training to include newer but relevant courses on health management in addition to the existing ones, whereas also advocating that doctors be incentivized to go for professional training in health management and not only in the core clinical specialties.

  8. Current role of transient elastography in the management of chronic hepatitis B patients

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jung Hwan; Lee, Jung Il [Dept. of Internal Medicine, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2017-04-15

    Liver fibrosis is an important prognostic factor for chronic hepatitis B (CHB), and accurate evaluation of the stage of liver fibrosis is crucial in establishing management strategies. While liver biopsy is still considered the gold standard for staging liver fibrosis or cirrhosis, transient elastography (TE), a noninvasive means of assessing liver fibrosis, has come to play an increasing role in this process. After extensive validation, TE is now regarded as a reliable surrogate maker for grading the severity of liver fibrosis in CHB patients. It can detect the extent of fibrosis in a patient and can also be used to evaluate longitudinal changes in liver fibrosis over time with or without interventional management, such as antiviral therapy. However, several confounders hinder the effective assessment of liver fibrosis using TE, such as extensive liver necroinflammation, hepatic congestion, and cholestasis. TE has limited use in obese patients or patients with ascites. Although TE has several limitations, due to its accessibility and safety, it is a valuable tool for the initial evaluation and follow-up in patients with CH.

  9. The Role of Stem Cell Therapeutics in Wound Healing: Current Understanding and Future Directions.

    Science.gov (United States)

    Sorice, Sarah; Rustad, Kristine C; Li, Alexander Y; Gurtner, Geoffrey C

    2016-09-01

    Chronic wounds present unique challenges for healthcare providers as they place patients at increased risk for various morbidities and mortality. Advances in wound care technology have expanded the treatment options available for wound management, but few products fully address the underlying core deficiencies responsible for the development of poorly healing wounds. In the future, addressing these derangements will undoubtedly play a key role in the treatment of these patients. Broad enthusiasm has surrounded the field of stem cell biology, which has shown great promise in repairing damaged tissues across numerous disease phenotypes. In this review, we provide a comprehensive review of the literature and evaluate the present landscape of wound therapeutics while discussing the rationales and allure behind stem cell-based products. We further propose 2 challenges that remain as new stem cell-based therapies are being developed and as this technology moves toward clinical translation. Given the relatively young age of this newer technology in wound healing, numerous challenges continue to surround its effective use including identifying the ideal population of stem cells to use and determining the optimal cell delivery method. However, significant forward progress has been made, with several clinical trials beginning to demonstrate reliable clinical benefit. The upward trajectory of stem cell technologies provides an exciting opportunity to positively impact patient outcomes through the controlled application of regenerative cell-based therapy.

  10. The role of tramadol in current treatment strategies for musculoskeletal pain

    Science.gov (United States)

    Schug, Stephan A

    2007-01-01

    Non-selective and cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drugs (NSAIDs) have been the mainstay of treatment for musculoskeletal pain of moderate intensity. However, in addition to gastrointestinal and renal toxicity, an increased cardiovascular risk may be a class effect for all NSAIDs. Despite these safety risks and the acknowledged ceiling effect of NSAIDs, many doctors still use them to treat moderate, mostly musculoskeletal pain. Recent guidelines for treating osteoarthritis and low back pain, issued by numerous professional medical societies, recommend NSAIDs and COX-2 inhibitors only in strictly defined circumstances, at the lowest effective dose and for the shortest possible period of time. These recent guidelines bring more focus to the usage of paracetamol and opioids. But opioids still remain under-utilized, although they are effective with minimal organ toxicity. In this setting, the atypical, centrally acting analgesic tramadol offers important benefits. Its multi-modal effect results from a dual mode of action, ie, opioid and monoaminergic mechanisms, with efficacy in both nociceptive and neuropathic pain. Moreover, fewer instances of side effects such as constipation, respiratory depression, and sedation occur than with traditional opioids, and tramadol has been prescribed for 30 years for a broad range of indications. Tramadol is now regarded as the first-line analgesic for many musculoskeletal indications. In conclusion, it is recommended to better implement the more recent guidelines focusing on pain management and consider the role of tramadol in musculoskeletal pain treatment strategies. PMID:18472996

  11. Role of government in public health: Current scenario in India and future scope

    Directory of Open Access Journals (Sweden)

    Subitha Lakshminarayanan

    2011-01-01

    Full Text Available The new agenda for Public Health in India includes the epidemiological transition, demographical transition, environmental changes and social determinants of health. Based on the principles outlined at Alma-Ata in 1978, there is an urgent call for revitalizing primary health care in order to meet these challenges. The role of the government in influencing population health is not limited within the health sector but also by various sectors outside the health systems. This article is a literature review of the existing government machinery for public health needs in India, its success, limitations and future scope. Health system strengthening, human resource development and capacity building and regulation in public health are important areas within the health sector. Contribution to health of a population also derives from social determinants of health like living conditions, nutrition, safe drinking water, sanitation, education, early child development and social security measures. Population stabilization, gender mainstreaming and empowerment, reducing the impact of climate change and disasters on health, improving community participation and governance issues are other important areas for action. Making public health a shared value across the various sectors is a politically challenging strategy, but such collective action is crucial.

  12. The sponge pump: the role of current induced flow in the design of the sponge body plan.

    Directory of Open Access Journals (Sweden)

    Sally P Leys

    Full Text Available Sponges are suspension feeders that use flagellated collar-cells (choanocytes to actively filter a volume of water equivalent to many times their body volume each hour. Flow through sponges is thought to be enhanced by ambient current, which induces a pressure gradient across the sponge wall, but the underlying mechanism is still unknown. Studies of sponge filtration have estimated the energetic cost of pumping to be 0.75 with the ambient current velocity. During short bursts of high ambient current the sponges filtered two-thirds of the total volume of water they processed daily. Our model indicates that the head loss across the sponge collar filter is 10 times higher than previously estimated. The difference is due to the resistance created by a fine protein mesh that lines the collar, which demosponges also have, but was so far overlooked. Applying our model to the in situ measurements indicates that even modest pumping rates require an energetic expenditure of at least 28% of the total in situ respiration. We suggest that due to the high cost of pumping, current-induced flow is highly beneficial but may occur only in thin walled sponges living in high flow environments. Our results call for a new look at the mechanisms underlying current-induced flow and for reevaluation of the cost of biological pumping and its evolutionary role, especially in sponges.

  13. How stakeholders frame dam removal: The role of current and anticipated future ecosystem service use

    Science.gov (United States)

    Reilly, Kate; Adamowski, Jan

    2016-04-01

    Many river restoration projects, including dam removal, are controversial and can trigger conflicts between stakeholders who are for and against the proposed project. The study of environmental conflicts suggests that differences in how stakeholders 'frame', or make sense of a situation based on their prior knowledge and experiences, can perpetuate conflicts. Understanding different stakeholders' frames, particularly how they converge, can form the basis of successful conflict resolution. In the case of dam removals, it is often assumed that emphasising increased provision of ecosystem services can be a point of convergence between those advocating for ecological restoration and those opposed to removal because of negative human impacts. However, how exactly stakeholders frame a contentious proposed dam removal and how those frames relate to ecosystem services has been little studied. Here we used the case of a potential dam removal in New Brunswick to investigate how people frame the issue and how that relates to their current and anticipated future use of ecosystem services. Based on in-depth interviews with 30 stakeholders in the area, including both people for and against dam removal, we found that both groups currently used ecosystem services and were in favour of ecosystem protection. However, they differed in how they framed the issue of the potential dam removal. The group against dam removal framed the issue as one of loss and risk - they thought that any potential benefits to the ecosystem would be outweighed by the high risk of negative social impacts caused by a loss of access to ecosystem services, such as recreation and aesthetic enjoyment. By contrast, the group in favour of the dam framed the issue as one of opportunity and justice. They thought that following a short transition period, all stakeholders would benefit from the restored river, particularly from a restored salmon fishery, improved aesthetic appeal and the long-term sustainability of an

  14. Psychosocial factors and their role in chronic pain: A brief review of development and current status

    Directory of Open Access Journals (Sweden)

    Innes Stanley I

    2005-04-01

    Full Text Available Abstract The belief that pain is a direct result of tissue damage has dominated medical thinking since the mid 20th Century. Several schools of psychological thought proffered linear causal models to explain non-physical pain observations such as phantom limb pain and the effects of placebo interventions. Psychological research has focused on identifying those people with acute pain who are at risk of transitioning into chronic and disabling pain, in the hope of producing better outcomes. Several multicausal Cognitive Behavioural models dominate the research landscape in this area. They are gaining wider acceptance and some aspects are being integrated and implemented into a number of health care systems. The most notable of these is the concept of Yellow Flags. The research to validate the veracity of such programs has not yet been established. In this paper I seek to briefly summarize the development of psychological thought, both past and present, then review current cognitive-behavioural models and the available supporting evidence. I conclude by discussing these factors and identifying those that have been shown to be reliable predictors of chronicity and those that may hold promise for the future.

  15. [Role of classical oral glucose-lowering medications in current treatment].

    Science.gov (United States)

    Carramiñana Barrera, F C

    2014-07-01

    Classical oral glucose were discovered in the mid twentieth century. Despite the time elapsed since then and the lack of large studies to support the use of some of these drugs, they continue to be employed, are indicated in all clinical practice guidelines and consensus documents and, overall, remain among the most widely prescribed drugs in the national health system. The main arguments for their continued use are their widespread and prolonged prescription, their effectiveness, and cost. Their main disadvantages have always been and continue to be their adverse gastrointestinal effects, weight gain, the risk of hypoglycemia and other adverse effects, which have encouraged the development of new glucose-lowering drugs with an improved pharmacological profile that would cover the various mechanisms of hyperglycemia. Currently, deep knowledge of glucose-lowering drugs is required in the patient-centered management of diabetes. Furthermore, this knowledge should be adapted to each individual patient to acquire the experience necessary to achieve effective metabolic control, delay the development of chronic complications, and improve the quality of life and life expectancy of patients with diabetes. Copyright © 2014 Elsevier España, S.L.U. y Sociedad Española de Medicina Rural y Generalista (SEMERGEN). All rights reserved.

  16. The current role of simulators for performance evaluations and licensing (case of Mexico)

    International Nuclear Information System (INIS)

    Maldonado A, H.

    1997-01-01

    The main purpose of this paper is to share the experience acquired by the National Commission of Nuclear Safety and Safeguards (CNSNS) during the administration of both certification and licensing operational exams applied to Senior Reactor Operators (SRO) and Reactor OPerators (RO) by using a full-scope simulator. The licensing operational exams are administered to examinate candidates for a SRO or RO license while the certification operational exams are administered to all personnel that possess a SRO or RO license in order to renew their licenses within a six years period. A general description with the most important simulator antecedents from the initial authorization for its usage to provide the ''Initial Simulator Training Course'' until currently in which it has been started the installation and testing performance of a new computer equipment that will improve and increase the simulation capacity of the Laguna Verde Nuclear Power Plant (LVNPP) simulator. In other hand, it is showed the process that the CNSNS will apply during the next verification of the simulator certification which should be performed due to the old computer equipment is being replaced with a more modern computer equipment so that the simulation capability will be improved. The verification process was discussed with the utility personnel and as result of this an agreement has been established to carry into effect this hard task. Finally, the conclusions and recommendations from regulators point of view are presented regarding to the importance of perform a well both evaluation and verification of simulators performance. (author)

  17. Current Role for Biomarkers in Clinical Diagnosis of Alzheimer Disease and Frontotemporal Dementia.

    Science.gov (United States)

    Sheikh-Bahaei, Nasim; Sajjadi, Seyed Ahmad; Pierce, Aimee L

    2017-11-14

    Purpose of review Alzheimer's disease (AD) and frontotemporal dementia can often be diagnosed accurately with careful clinical history, cognitive testing, neurological examination, and structural brain MRI. However, there are certain circumstances wherein detection of specific biomarkers of neurodegeneration or underlying AD pathology will impact the clinical diagnosis or treatment plan. We will review the currently available biomarkers for AD and frontotemporal dementia (FTD) and discuss their clinical importance. Recent findings With the advent of 18 F-labeled tracers that bind amyloid plaques, amyloid PET is now clinically available for the detection of amyloid pathology and to aid in a biomarker-supported diagnosis of AD or mild cognitive impairment (MCI) due to AD. It is not yet possible to test for the specific FTD pathologies (tau or TDP-43); however, a diagnosis of FTD may be "imaging supported" based upon specific MRI or FDG-PET findings. Cerebrospinal fluid measures of amyloid-beta, total-tau, and phospho-tau are clinically available and allow detection of both of the cardinal pathologies of AD: amyloid and tau pathology. Summary It is appropriate to pursue biomarker testing in cases of MCI and dementia when there remains diagnostic uncertainty and the result will impact diagnosis or treatment. Practically speaking, due to the rising prevalence of amyloid positivity with advancing age, measurement of biomarkers in cases of MCI and dementia is most helpful in early-onset patients, patients with atypical clinical presentations, or when considering referral for AD clinical trials.

  18. Current & Heat Transport in Graphene Nanoribbons: Role of Non-Equilibrium Phonons

    Science.gov (United States)

    Pennington, Gary; Finkenstadt, Daniel

    2010-03-01

    The conducting channel of a graphitic nanoscale device is expected to experience a larger degree of thermal isolation when compared to traditional inversion channels of electronic devices. This leads to enhanced non-equilibrium phonon populations which are likely to adversely affect the mobility of graphene-based nanoribbons due to enhanced phonon scattering. Recent reports indicating the importance of carrier scattering with substrate surface polar optical phonons in carbon nanotubes^1 and graphene^2,3 show that this mechanism may allow enhanced heat removal from the nanoribbon channel. To investigate the effects of hot phonon populations on current and heat conduction, we solve the graphene nanoribbon multiband Boltzmann transport equation. Monte Carlo transport techniques are used since phonon populations may be tracked and updated temporally.^4 The electronic structure is solved using the NRL Tight-Binding method,^5 where carriers are scattered by confined acoustic, optical, edge and substrate polar optical phonons. [1] S. V. Rotkin et al., Nano Lett. 9, 1850 (2009). [2] J. H. Chen, C. Jang, S. Xiao, M. Ishigami and M. S. Fuhrer, Nature Nanotech. 3, 206 (2008). [3] V. Perebeinos and P. Avouris, arXiv:0910.4665v1 [cond-mat.mes-hall] (2009). [4] P. Lugli et al., Appl. Phys. Lett. 50, 1251 (1987). [5] D. Finkenstadt, G. Pennington & M.J. Mehl, Phys. Rev. B 76, 121405(R) (2007).

  19. Current and future role of genetic screening in gynecologic malignancies.

    Science.gov (United States)

    Ring, Kari L; Garcia, Christine; Thomas, Martha H; Modesitt, Susan C

    2017-11-01

    The world of hereditary cancers has seen exponential growth in recent years. While hereditary breast and ovarian cancer and Lynch syndrome account for the majority of mutations encountered by gynecologists, newly identified deleterious genetic mutations continue to be unearthed with their associated risks of malignancies. However, these advances in genetic cancer predispositions then force practitioners and their patients to confront the uncertainties of these less commonly identified mutations and the fact that there is limited evidence to guide them in expected cancer risk and appropriate risk-reduction strategies. Given the speed of information, it is imperative to involve cancer genetics experts when counseling these patients. In addition, coordination of screening and care in conjunction with specialty high-risk clinics, if available, allows for patients to have centralized management for multiple cancer risks under the guidance of physicians with experience counseling these patients. The objective of this review is to present the current literature regarding genetic mutations associated with gynecologic malignancies as well to propose screening and risk-reduction options for these high-risk patients. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Some current problems in atmospheric ozone chemistry; role of chemical kinetics

    Energy Technology Data Exchange (ETDEWEB)

    Cox, R.A.

    1987-03-01

    A review is given on selected aspects of the reaction mechanisms of current interest in the chemistry of atmospheric ozone. Atmospheric ozone is produced and removed by a complex series of elementary gas-phase photochemical reactions involving O/sub x/, HO/sub x/, NO/sub x/, CIO/sub x/ and hydrocarbon species. At the present time there is a good knowledge of the basic processes involved in ozone chemistry in the stratosphere and the troposphere and the kinetics of most of the key reactions are well defined. There are a number of difficulties in the theoretical descriptions of observed ozone behaviour which may be due to uncertainties in the chemistry. Examples are the failure to predict present day ozone in the photochemically controlled region above 35 Km altitude and the large reductions in the ozone column in the Antartic Spring which has been observed in recent years. In the troposphere there is growing evidence that ozone and other trace gases have changed appreciably from pre-industrial concentrations, due to chemical reactions involving man-made pollutants. Quantitative investigation of the mechanisms by which these changes may occur requires a sound laboratory kinetics data base.

  1. Navigating the Role of Business Incubators: A Review on the Current Literature on Business Incubation in South Africa

    Directory of Open Access Journals (Sweden)

    Thobekani Lose

    2016-10-01

    Full Text Available Business incubators (BIs are a significant tool in promoting the development of entrepreneurial firms, technology-based growth firms and economic growth in South Africa. The study reviewed the current literature on business incubation in South Africa. BIs in South Africa emerged as a popular strategy in the 1990s and most of the current literature was established in the same period. However, the current literature is still limited. The aim of this paper is to provide an overview of existing knowledge on the role and effectiveness of business incubation in supporting the development of new small startup businesses. The quantitative and qualitative literature published by the academic and practitioner communities is reviewed. The searches indicated that incubation has encouraged many studies in South Africa. The studies can be categorised under the following themes: the role and contribution of incubators, success factors for business incubation, obstacles, and the relationship between incubators and entrepreneurship. The areas for further research are suggested. Two major areas that new research can explore focus on the creation of the model and selfsustainability of BIs.

  2. PingFederate

    Data.gov (United States)

    US Agency for International Development — PingFederate Server provides Identity Federation and Single Sign On Capabilities. Federated identity management (or identity federation) enables enterprises to...

  3. The Metal Neurotoxins: An Important Role in Current Human Neural Epidemics?

    Directory of Open Access Journals (Sweden)

    Keith Schofield

    2017-12-01

    Full Text Available Many published studies have illustrated that several of the present day neurological epidemics (autism, attention deficit disorder, Alzheimer’s cannot be correlated to any single neurotoxicant. However, the present scientific examination of the numerous global blood monitoring databases for adults that include the concentrations of the neurotoxic elements, aluminum (Al, arsenic (As, lead (Pb, manganese (Mn, mercury (Hg, and selenium (Se clearly indicate that, when considered in combination, for some, the human body may become easily over-burdened. This can be explained by changes in modern lifestyles. Similar data, solely for pregnant women, have been examined confirming this. All these elements are seen to be present in the human body and at not insignificant magnitudes. Currently suggested minimum risk levels (MRL for humans are discussed and listed together with averages of the reported distributions, together with their spread and maximum values. One observation is that many distributions for pregnant women are not too dissimilar from those of general populations. Women obviously have their individual baseline of neurotoxin values before pregnancy and any efforts to modify this to any significant degree is not yet clearly apparent. For any element, distribution shapes are reasonably similar showing broad distributions with extended tails with numerous outlier values. There are a certain fraction of people that lie well above the MRL values and may be at risk, especially if genetically susceptible. Additionally, synergistic effects between neurotoxins and with other trace metals are now also being reported. It appears prudent for women of child-bearing age to establish their baseline values well before pregnancy. Those at risk then can be better identified. Adequate instrumental testing now is commercially available for this. In addition, directives are necessary for vaccination programs to use only non-neurotoxic adjuvants, especially for

  4. Role of biologics and biosimilars in inflammatory bowel disease: current trends and future perspectives

    Directory of Open Access Journals (Sweden)

    Rawla P

    2018-05-01

    Full Text Available Prashanth Rawla,1 Tagore Sunkara,2 Jeffrey Pradeep Raj3 1Department of Internal Medicine, Memorial Hospital of Martinsville and Henry County, Martinsville, VA, 2Division of Gastroenterology and Hepatology, The Brooklyn Hospital Center, Clinical Affiliate of The Mount Sinai Hospital, New York, NY, USA; 3Department of Pharmacology, St John’s Medical College, Bangalore, India Abstract: Inflammatory bowel disease (IBD is an idiopathic chronic inflammatory disease of the gastrointestinal system. The spectrum is of predominantly two types, namely, ulcerative colitis and Crohn’s disease. The incidence of IBD has been increasing steadily since 1990, and so the number of agents used in their treatment. Biologics that are derived partly or completely from living biological sources such as animals and humans have become widely available, which provide therapeutic benefits to the IBD patients. Currently, monoclonal antibodies against tumor necrosis factor-alpha (infliximab, adalimumab, certolizumab, and golimumab, integrins (vedolizumab and natalizumab, and interleukin (IL-12 and IL-23 antagonists (ustekinumab are approved for use in IBD. Biosimilars of infliximab and adalimumab are also available for the treatment of IBD. This review summarizes the clinical pharmacology, studies leading to their approval, overall indications and their use in IBD, usage in pregnancy and lactation, and the adverse effects of these agents. This review also summarizes the recent advances and future perspectives specific to biologics and biosimilars in IBD. Keywords: inflammatory bowel disease, Crohn’s disease, ulcerative colitis, biologics, biosimilars, tumor necrosis factor, integrin, interleukin, adalimumab, Humira®, certolizumab, Cimzia®, golimumab, Simponi®, infliximab, Remicade®, vedolizumab, Entyvio, natalizumab, Tysabri®, ustekinumab, Stelara® 

  5. The Current and Future Role of Nigerian Indigenous Oil Companies in the Mature Niger Delta

    International Nuclear Information System (INIS)

    David Rowlands, Spectrum Energy and Information Technology Ltd

    2002-01-01

    Over the last 10 years, there has been a steady increase in the number of successful Indigenous Oil Companies exploring for hydrocarbons in the Niger Delta. A number of these companies have already entered into partnership agreements with overseas based oil companies, however, many more are still seeking technical and financial partnership agreements with overseas based oil companies, however, many more are still seeking technical and financial partners to fulfil their licence commitments. The first exploration licence to an Indigenous Company was awarded in the mid eighties. However, it wasn't until the early nineties that the Nigerian Government's intention to privatise the oil industry gathered momentum. Between 1991 and 1993 a number of discretionary awards of acreage from various sedimentary basins in Nigeria were made to Nigerian Indigenous Companies. Many of these companies had little or no previous experience of hydrocarbon exploration.Sixteen of the Indigenous Companies have already reported discoveries in various parts of the delta, either in partnerships with foreign companies or independently. Eight of the Indigenous Companies are producing hydrocarbons. With very little production in the early 90's, the Indigenous Companies now account for over 4.5% of Nigeria's daily production. The government is intent on increasing this percentage through initiatives such as the Marginal Fields re-allocation programme, and the continued award of acreage in traditional license rounds. This paper takes a closer look at the operations and discoveries of two Indigenous Companies Solgas and Summit with the aim of providing an insight into the structure and mode of operation of typical Nigerian Indigenous Oil Companies.The more recent licensing activity in Nigeria includes the current Marginal Fields re-allocation programme and also possible participation of Nigerian companies in the join Development Zone between Nigeria and Sao Tome and Principe. The paper concludes with

  6. Role of interannual Kelvin wave propagations in the equatorial Atlantic on the Angola Benguela Current system

    Science.gov (United States)

    Imbol Koungue, Rodrigue Anicet; Illig, Serena; Rouault, Mathieu

    2017-06-01

    The link between equatorial Atlantic Ocean variability and the coastal region of Angola-Namibia is investigated at interannual time scales from 1998 to 2012. An index of equatorial Kelvin wave activity is defined based on Prediction and Research Moored Array in the Tropical Atlantic (PIRATA). Along the equator, results show a significant correlation between interannual PIRATA monthly dynamic height anomalies, altimetric monthly Sea Surface Height Anomalies (SSHA), and SSHA calculated with an Ocean Linear Model. This allows us to interpret PIRATA records in terms of equatorial Kelvin waves. Estimated phase speed of eastward propagations from PIRATA equatorial mooring remains in agreement with the linear theory, emphasizing the dominance of the second baroclinic mode. Systematic analysis of all strong interannual equatorial SSHA shows that they precede by 1-2 months extreme interannual Sea Surface Temperature Anomalies along the African coast, which confirms the hypothesis that major warm and cold events in the Angola-Benguela current system are remotely forced by ocean atmosphere interactions in the equatorial Atlantic. Equatorial wave dynamics is at the origin of their developments. Wind anomalies in the Western Equatorial Atlantic force equatorial downwelling and upwelling Kelvin waves that propagate eastward along the equator and then poleward along the African coast triggering extreme warm and cold events, respectively. A proxy index based on linear ocean dynamics appears to be significantly more correlated with coastal variability than an index based on wind variability. Results show a seasonal phasing, with significantly higher correlations between our equatorial index and coastal SSTA in October-April season.

  7. Phylogeography of Ophioblennius: the role of ocean currents and geography in reef fish evolution.

    Science.gov (United States)

    Muss, A; Robertson, D R; Stepien, C A; Wirtz, P; Bowen, B W

    2001-03-01

    Many tropical reef fishes are divided into Atlantic and East Pacific taxa, placing similar species in two very different biogeographic regimes. The tropical Atlantic is a closed ocean basin with relatively stable currents, whereas the East Pacific is an open basin with unstable oceanic circulation. To assess how evolutionary processes are influenced by these differences in oceanography and geography, we analyze a 630-bp region of mitochondrial cytochrome b from 171 individuals in the blenniid genus Ophioblennius. Our results demonstrate deep genetic structuring in the Atlantic species, O. atlanticus, corresponding to recognized biogeographic provinces, with divergences of d = 5.2-12.7% among the Caribbean, Brazilian, St. Helena/Ascension Island, Gulf of Guinea, and Azores/Cape Verde regions. The Atlantic phylogeny is consistent with Pliocene dispersal from the western to eastern Atlantic, and the depth of these separations (along with prior morphological comparisons) may indicate previously unrecognized species. The eastern Pacific species, O. steindachneri, is characterized by markedly less structure than O. atlanticus, with shallow mitochondrial DNA lineages (dmax = 2.7%) and haplotype frequency shifts between locations in the Sea of Cortez, Pacific Panama, Clipperton Island, and the Galapagos Islands. No concordance between genetic structure and biogeographic provinces was found for O. steincdachneri. We attribute the phylogeographic pattern in O. atlanticus to dispersal during the reorganization of Atlantic circulation patterns that accompanied the shoaling of the Isthmus of Panama. The low degree of structure in the eastern Pacific is probably due to unstable circulation and linkage to the larger Pacific Ocean basin. The contrast in genetic signatures between Atlantic and eastern Pacific blennies demonstrates how differences in geology and oceanography have influenced evolutionary radiations within each region.

  8. Creeping Federalization

    DEFF Research Database (Denmark)

    Sweeney, Richard J.

    2003-01-01

    that make taxharmonization difficult to impose. Other types of harmonization have a less clear-cut costbenefitanalysis. A federal commercial code that is uniform across member states reducestransaction and information costs, compared to leaving important code issues to memberstates; further, many states may...

  9. CURRENT APPROACHES TO THE LABORATORY DIAGNOSIS OF RHEUMATIC DISEASES: ROLE OF MOLECULAR AND CELLULAR BIOMARKERS

    Directory of Open Access Journals (Sweden)

    E. N. Aleksandrova

    2016-01-01

    .The alternative therapies of RD include the use of low-molecular-weight chemically synthesized agents that suppress the activity of tyrosine kinases. The important area of this therapy is to restore immunological tolerance and to correct autoimmune disorders by means of autologous hematopoietic stem cells, mesenchymal stromal cells, autologous tolerogenic dendritic cells, regulatory T and B cells, gene therapy, and peptide antigens. The prospects for the laboratory diagnosis of RD are associated with the necessity of harmonizing and standardizing the current methods to determine autoantibodies and with the search for and clinical validation of novel proteomic, transcriptomic, and genomic biomarkers.

  10. Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure.

    Directory of Open Access Journals (Sweden)

    Beatriz Trenor

    Full Text Available Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na(+ current (I(NaL is relevant and is currently under investigation. In this study we examined the role of I(NaL in the electrophysiological phenotype of ventricular myocytes, and its proarrhythmic effects in the failing heart. A model for cellular heart failure was proposed using a modified version of Grandi et al. model for human ventricular action potential that incorporates the formulation of I(NaL. A sensitivity analysis of the model was performed and simulations of the pathological electrical activity of the cell were conducted. The proposed model for the human I(NaL and the electrophysiological remodeling of myocytes from failing hearts accurately reproduce experimental observations. The sensitivity analysis of the modulation of electrophysiological parameters of myocytes from failing hearts due to ion channels remodeling, revealed a role for I(NaL in the prolongation of action potential duration (APD, triangulation of the shape of the AP, and changes in Ca(2+ transient. A mechanistic investigation of intracellular Na(+ accumulation and APD shortening with increasing frequency of stimulation of failing myocytes revealed a role for the Na(+/K(+ pump, the Na(+/Ca(2+ exchanger and I(NaL. The results of the simulations also showed that in failing myocytes, the enhancement of I(NaL increased the reverse rate-dependent APD prolongation and the probability of initiating early afterdepolarizations. The electrophysiological remodeling of failing hearts and especially the enhancement of the I(NaL prolong APD and alter Ca(2+ transient facilitating the development of early afterdepolarizations. An enhanced I(NaL appears to be an important contributor to the electrophysiological phenotype and to the dysregulation of [Ca(2+](i homeostasis of failing myocytes.

  11. Perception of community pharmacists toward their current professional role in the healthcare system of Dubai, United Arab Emirates.

    Science.gov (United States)

    Rayes, Ibrahim Khalid; Hassali, Mohamed Azmi; Abduelkarem, Abduelmula R

    2015-07-01

    The new paradigm to pharmacy profession has changed the focus of pharmacists from product-centered to patient-oriented. This change has brought new set of beliefs and assumptions on the way services should be delivered to pharmacy clients. The main aim of this study was to explore the perception of community pharmacists on their current professional role in Dubai. Key findings show that community pharmacists are more directed toward business than patients. They almost dispense all categories of medicines over-the-counter without the need of prescriptions. However, a new trend of pharmacists in Dubai is to provide enhanced pharmacy services such as consultation to patients upon request.

  12. A role for biological optimization within the current treatment planning paradigm

    International Nuclear Information System (INIS)

    Das, Shiva

    2009-01-01

    reduced (after DVO) by 5.0%/3.9%, and highest doses were reduced by 4.6%/7.8%. The optimization with purely biological OAR objectives achieved bladder/rectal EUDs that were 7.4%/3.1% lower than from DVO, but only reduced highest doses by 1.4%/0.7%. In the olfactory neuroblastoma case, the target was closely surrounded by the eyes, optic nerves, chiasm, and brainstem. In one of the scenarios studied, the eyes, optic nerves, and chiasm were targeted for EUD reduction after DVO. EUD to the left eye, right eye, left optic nerve, right optic nerve, and chiasm were reduced by 7.0%, 5.7%, 4.7%, 4.1%, and 0.6%, respectively, and highest doses were reduced by 16.5%, 11.0%, 5.1%, 3.8%, and 1.5%, respectively. The optimization with purely biological OAR objectives was less effective for the eyes and optics nerves. EUDs for the left eye/right eye/left optic nerve/right optic nerve/chiasm were lower than that from DVO by 0.4%/2.7%/4.0%/2.8%/15.6% and highest doses were lower by 4.6%/1.4%/2.4%/6.4%/7.1% (but purely biological optimization was better overall for the OARs not targeted for EUD reduction). Conclusions: Incorporating biological optimization after dose-volume constrained optimization can further reduce biological metrics, while preserving the important dose reductions achieved by dose-volume constrained optimization. Thus, biological optimization may be accommodated within the framework of current IMRT planning clinical expectations.

  13. State-federal interactions in nuclear regulation

    Energy Technology Data Exchange (ETDEWEB)

    Pasternak, A.D.; Budnitz, R.J.

    1987-12-01

    The Atomic Energy Act of 1954 established, and later Congressional amendments have confirmed, that except in areas which have been explicitly granted to the states, the federal government possesses preemptive authority to regulate radiation hazards associated with the development and use of atomic energy. Since the passage of the original Act, numerous decisions by the courts have reaffirmed the legitimacy of federal preemption, and have defined and redefined its scope. In this study, the aim is to explore the underlying issues involved in federal preemption of radiation-hazard regulation, and to recommend actions that the Department of Energy and other agencies and groups should consider undertaking in the near term to protect the preemption principle. Appropriate roles of the states are discussed, as well as recent state-level activities and their rationale, and several current arenas in which state-federal conflicts about regulation of hazards are being played out. The emphasis here is on four particular arenas that are now important arenas of conflict, but the issues discussed are far broader in scope. These four arenas are: state-level moratorium activity; emergency planning for reactors; conflicts arising from state financial regulation; and inroads in federal preemption through litigation under state law.

  14. State-federal interactions in nuclear regulation

    International Nuclear Information System (INIS)

    Pasternak, A.D.; Budnitz, R.J.

    1987-12-01

    The Atomic Energy Act of 1954 established, and later Congressional amendments have confirmed, that except in areas which have been explicitly granted to the states, the federal government possesses preemptive authority to regulate radiation hazards associated with the development and use of atomic energy. Since the passage of the original Act, numerous decisions by the courts have reaffirmed the legitimacy of federal preemption, and have defined and redefined its scope. In this study, the aim is to explore the underlying issues involved in federal preemption of radiation-hazard regulation, and to recommend actions that the Department of Energy and other agencies and groups should consider undertaking in the near term to protect the preemption principle. Appropriate roles of the states are discussed, as well as recent state-level activities and their rationale, and several current arenas in which state-federal conflicts about regulation of hazards are being played out. The emphasis here is on four particular arenas that are now important arenas of conflict, but the issues discussed are far broader in scope. These four arenas are: state-level moratorium activity; emergency planning for reactors; conflicts arising from state financial regulation; and inroads in federal preemption through litigation under state law

  15. Federal databases

    International Nuclear Information System (INIS)

    Welch, M.J.; Welles, B.W.

    1988-01-01

    Accident statistics on all modes of transportation are available as risk assessment analytical tools through several federal agencies. This paper reports on the examination of the accident databases by personal contact with the federal staff responsible for administration of the database programs. This activity, sponsored by the Department of Energy through Sandia National Laboratories, is an overview of the national accident data on highway, rail, air, and marine shipping. For each mode, the definition or reporting requirements of an accident are determined and the method of entering the accident data into the database is established. Availability of the database to others, ease of access, costs, and who to contact were prime questions to each of the database program managers. Additionally, how the agency uses the accident data was of major interest

  16. The Federal Role in Meeting the Education Needs of Chicanos and Puerto Ricans with Special Emphasis on Higher Education. Final Report.

    Science.gov (United States)

    Miranda (L.) and Associates, Bethesda, MD.

    Federal efforts to meet higher educational needs of Chicanos and Puerto Ricans are analyzed in this report. As part of a study conducted by L. Miranda and Associates, 15 Federal agencies were surveyed to determine their programs and their financial commitment to Hispanic postsecondary education, and the participation of Hispanics in each agency's…

  17. Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A.

    Science.gov (United States)

    Seyler, Claudia; Scherer, Daniel; Köpple, Christoph; Kulzer, Martin; Korkmaz, Sevil; Xynogalos, Panagiotis; Thomas, Dierk; Kaya, Ziya; Scholz, Eberhard; Backs, Johannes; Karle, Christoph; Katus, Hugo A; Zitron, Edgar

    2017-05-01

    The cardiac I K1 current stabilizes the resting membrane potential of cardiomyocytes. Protein kinase A (PKA) induces an inhibition of I K1 current which strongly promotes focal arrhythmogenesis. The molecular mechanisms underlying this regulation have only partially been elucidated yet. Furthermore, the role of A-kinase anchoring proteins (AKAPs) in this regulation has not been examined to date. The objective of this project was to elucidate the molecular mechanisms underlying the inhibition of I K1 by PKA and to identify novel molecular targets for antiarrhythmic therapy downstream β-adrenoreceptors. Patch clamp and voltage clamp experiments were used to record currents and co-immunoprecipitation, and co-localization experiments were performed to show spatial and functional coupling. Activation of PKA inhibited I K1 current in rat cardiomyocytes. This regulation was markedly attenuated by disrupting PKA-binding to AKAPs with the peptide inhibitor AKAP-IS. We observed functional and spatial coupling of the plasma membrane-associated AKAP15 and AKAP79 to Kir2.1 and Kir2.2 channel subunits, but not to Kir2.3 channels. In contrast, AKAPyotiao had no functional effect on the PKA regulation of Kir channels. AKAP15 and AKAP79 co-immunoprecipitated with and co-localized to Kir2.1 and Kir2.2 channel subunits in ventricular cardiomyocytes. In this study, we provide evidence for coupling of cardiac Kir2.1 and Kir2.2 subunits with the plasma membrane-bound AKAPs 15 and 79. Cardiac membrane-associated AKAPs are a functionally essential part of the regulatory cascade determining I K1 current function and may be novel molecular targets for antiarrhythmic therapy downstream from β-adrenoreceptors.

  18. The Sponge Pump: The Role of Current Induced Flow in the Design of the Sponge Body Plan

    Science.gov (United States)

    Leys, Sally P.; Yahel, Gitai; Reidenbach, Matthew A.; Tunnicliffe, Verena; Shavit, Uri; Reiswig, Henry M.

    2011-01-01

    Sponges are suspension feeders that use flagellated collar-cells (choanocytes) to actively filter a volume of water equivalent to many times their body volume each hour. Flow through sponges is thought to be enhanced by ambient current, which induces a pressure gradient across the sponge wall, but the underlying mechanism is still unknown. Studies of sponge filtration have estimated the energetic cost of pumping to be sponge Aphrocallistes vastus at a 150 m deep reef in situ and in a flow flume; we also modeled the glass sponge filtration system from measurements of the aquiferous system. Excurrent flow from the sponge osculum measured in situ and in the flume were positively correlated (r>0.75) with the ambient current velocity. During short bursts of high ambient current the sponges filtered two-thirds of the total volume of water they processed daily. Our model indicates that the head loss across the sponge collar filter is 10 times higher than previously estimated. The difference is due to the resistance created by a fine protein mesh that lines the collar, which demosponges also have, but was so far overlooked. Applying our model to the in situ measurements indicates that even modest pumping rates require an energetic expenditure of at least 28% of the total in situ respiration. We suggest that due to the high cost of pumping, current-induced flow is highly beneficial but may occur only in thin walled sponges living in high flow environments. Our results call for a new look at the mechanisms underlying current-induced flow and for reevaluation of the cost of biological pumping and its evolutionary role, especially in sponges. PMID:22180779

  19. The Role of the New Zealand Plateau in the Tasman Sea Circulation and Separation of the East Australian Current

    Science.gov (United States)

    Bull, Christopher Y. S.; Kiss, Andrew E.; van Sebille, Erik; Jourdain, Nicolas C.; England, Matthew H.

    2018-02-01

    The East Australian Current (EAC) plays a major role in regional climate, circulation, and ecosystems, but predicting future changes is hampered by limited understanding of the factors controlling EAC separation. While there has been speculation that the presence of New Zealand may be important for the EAC separation, the prevailing view is that the time-mean partial separation is set by the ocean's response to gradients in the wind stress curl. This study focuses on the role of New Zealand, and the associated adjacent bathymetry, in the partial separation of the EAC and ocean circulation in the Tasman Sea. Here utilizing an eddy-permitting ocean model (NEMO), we find that the complete removal of the New Zealand plateau leads to a smaller fraction of EAC transport heading east and more heading south, with the mean separation latitude shifting >100 km southward. To examine the underlying dynamics, we remove New Zealand with two linear models: the Sverdrup/Godfrey Island Rule and NEMO in linear mode. We find that linear processes and deep bathymetry play a major role in the mean Tasman Front position, whereas nonlinear processes are crucial for the extent of the EAC retroflection. Contrary to past work, we find that meridional gradients in the basin-wide wind stress curl are not the sole factor determining the latitude of EAC separation. We suggest that the Tasman Front location is set by either the maximum meridional gradient in the wind stress curl or the northern tip of New Zealand, whichever is furthest north.

  20. New Federalism: Back to Basics.

    Science.gov (United States)

    Durenberger, Dave

    1983-01-01

    The senator explains the basic concepts of New Federalism, including a rethinking of responsibilities and intergovernmental relations and a reconsideration of the role of state and local government. (SK)

  1. A new direction for prioritizing federal agency cleanups

    International Nuclear Information System (INIS)

    McCrillis, L.

    1995-01-01

    Departments and agencies of the federal government manage a vast array of activities at 27,000 facilities. Due to the nature of such activities, federal facilities could be contaminated with hazardous substances. It is estimated that the federal government ultimately will be responsible for or have a significant role in the cleanup of up to 500,000 sites. Although federal facilities comprise only a small percentage of the community regulated under the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), federal facilities owned or operated by the Department of Energy (DOE) and the Department of Defense (DOD) are usually larger and more complex than their private industrial counterparts. Federal facilities routinely have a larger number of sites on their facilities with varying degrees of risk. At present, the approaches for allocating resources for environmental restoration of federal facilities, for incorporating stakeholder concerns in the allocation, and for obtaining funding from Congress vary greatly from one agency to another. In light of these concerns, the federal government recognizes the need to evaluate the current resource allocation system for funding remediation projects and to establish a broader-based publicly supported priority-setting method. This paper outlines a possible new direction and summarizes the conclusions reached in a handful of forums created to address the issue of priority setting

  2. Gender Diversity in Anesthesiology Programs: The Role of Current Residents and Department Leadership in the 2014 Match Results.

    Science.gov (United States)

    Kranner, Paul W; Mussehl, Denise A; Hess, Aaron S

    2016-01-01

    Nearly half of graduates of American medical colleges are women, yet the percentage of women entering accredited anesthesiology programs remains less than 40%. There are obviously many factors that influence the choice of a residency training program, from geography to reputation to the atmosphere, composition and camaraderie of the department. We examined whether a greater number of current female residents, a female Chair, or a female Program Director were associated with a program matching a greater number of female candidates in the 2014 NRMP Match. An electronic questionnaire was sent to all 132 ACGME-accredited anesthesiology programs immediately following the 2014 Match seeking information on the gender mix of their current residents, the gender of the Chair and Program Director, and the gender composition of their newly-matched candidates. The percentage of current female residents was significantly associated with the percentage of incoming female residents (p = 0.013). There was no association between the percentage of new female residents obtained in the Match and the presence of a female Chair or Program Director. The results of the 2013 NRMP anesthesiology match indicate that programs with a higher proportion of female residents were able to sustain that diversity and successfully match a higher percentage of female candidates. No correlation was seen with Chair and Program Director gender, suggesting further work is needed to define the influence of female role models on female applicants' choice of anesthesiology residency programs.

  3. THE ROLE OF EDUCATIONAL EFFECTIVENESS FOR THE STANDARD OF FEDERAL GOVERNMENTAL EDUCATION PROFESSIONAL HIGH EDUCATION IN THE PROFESSIONAL PREPARATION OF STUDENTS FOR THE PSYCHO-PEDAGOGICAL FIELD

    Directory of Open Access Journals (Sweden)

    Svetlana Petrovna Akutina

    2015-02-01

    Full Text Available The goal: the educational research of educational effectiveness FGOS PVO for the professional preparation.The research method and the methodological approach: to enlighten the goals of the Federal Governmental Education Standard (FGOS of the high professional education (VPO of the psycho-pedagogical field within the education system reforming; to create new didactical materials, programs, plans, training courses; to model the educational effectiveness of a high education institution according to the competence approach.The clue of the educational effectiveness is in the developing an individual educational path for students in the comprehensive phase, and as a result the role of an educator, and a tutor increases; the changes in social cultural sphere of an educational institution, the importance of students self-management are to remodel the formulating personal needs paradigm in professional, private, intellectual, cultural and modal advancing.The research results are to open valuable possibilities of educational effectiveness in FGOS VPO influencing the professional preparation, that is filled with innovative forms, me-thods, technological approaches in cooperation between students and educators; to organize socially oriented process within the educational and extra educational context, to construct an individual educational path to obtain a qualification, to guaranty the realization of a new educational system for educators’ cooperation, for tutors and social partners; all these permit to act in different cultural spheres acquiring positive experience of professional training.The application field: the research results are applied in the pedagogical activity to prepare professional figures in the psycho pedagogical area, in educational projects with students, in cooperating with various social partners.

  4. Fiscal Federalism

    DEFF Research Database (Denmark)

    Feng, Xingyuan; Ljungwall, Christer; Guo, Sujian

    2013-01-01

    China's central–local relations have been marked by perpetual changes amidst economic restructuring. Fiscal decentralization on the expenditure side has been paralleled by centralization on the revenue side, accompanied by political centralization. Hence, our understanding of China's fiscal...... relations is not without controversy. This paper aims to make a theoretical contribution to the ongoing debate on ‘fiscal federalism’ by addressing crucial questions regarding China's central–local fiscal relations: first, to what extent do Chinese central–local fiscal relations conform to fiscal federalism...

  5. Federal Interagency Geothermal Activities

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Arlene [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Prencipe, Loretta [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Todaro, Richard M. [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Cuyler, David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Eide, Elizabeth [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-06-01

    This collaborative document describes the roles and responsibilities of key Federal agencies in the development of geothermal technologies including the U.S. Department of Energy (DOE); the U.S. Department of Agriculture (USDA), including the U.S. Forest Service; the U.S. Department of Interior (DOI), including the United States Geological Survey (USGS) and Bureau of Land Management (BLM); the Environmental Protection Agency (EPA); and the Department of Defense (DOD).

  6. Evolution, current structure, and role of a primary care clinical pharmacy service in an integrated managed care organization.

    Science.gov (United States)

    Heilmann, Rachel M F; Campbell, Stephanie M; Kroner, Beverly A; Proksel, Jenel R; Billups, Sarah J; Witt, Daniel M; Helling, Dennis K

    2013-01-01

    The impact of the declining number of primary care physicians is exacerbated by a growing elderly population in need of chronic disease management. Primary care clinical pharmacy specialists, with their unique knowledge and skill set, are well suited to address this gap. At Kaiser Permanente of Colorado (KPCO), primary care clinical pharmacy specialists have a long history of integration with medical practices and are located in close proximity to physicians, nurses, and other members of the health care team. Since 1992, Primary Care Clinical Pharmacy Services (PCCPS) has expanded from 4 to 30 full-time equivalents (FTEs) to provide services in all KPCO medical office buildings. With this growth in size, PCCPS has evolved to play a vital role in working with primary care medical teams to ensure that drug therapy is effective, safe, and affordable. In addition, PCCPS specialists provide ambulatory teaching sites for pharmacy students and pharmacy residents. There is approximately 1 specialist FTE for every 13,000 adult KPCO members and every 9 clinical FTEs of internal medicine and family medicine physicians. All clinical pharmacy specialists in the pharmacy department are required to have a PharmD degree, to complete postgraduate year 2 residencies, and, as a condition of employment, to become board certified in an applicable specialty. The evolution, current structure, and role of PCCPS at KPCO, including factors facilitating successful integration within the medical team, are highlighted. Patient and nonpatient care responsibilities are described.

  7. Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Elena Bellavista

    2014-01-01

    Full Text Available The ubiquitin-proteasome system is the major intracellular molecular machinery for protein degradation and maintenance of protein homeostasis in most human cells. As ubiquitin-proteasome system plays a critical role in the regulation of the immune system, it might also influence the development and progression of multiple sclerosis (MS. Both ex vivo analyses and animal models suggest that activity and composition of ubiquitin-proteasome system are altered in MS. Proteasome isoforms endowed of immunosubunits may affect the functionality of different cell types such as CD8+ and CD4+ T cells and B cells as well as neurons during MS development. Furthermore, the study of proteasome-related biomarkers, such as proteasome antibodies and circulating proteasomes, may represent a field of interest in MS. Proteasome inhibitors are already used as treatment for cancer and the recent development of inhibitors selective for immunoproteasome subunits may soon represent novel therapeutic approaches to the different forms of MS. In this review we describe the current knowledge on the potential role of proteasomes in MS and discuss the pro et contra of possible therapies for MS targeting proteasome isoforms.

  8. A pivotal role for ocean eddies in the distribution of microbial communities across the Antarctic Circumpolar Current.

    Directory of Open Access Journals (Sweden)

    Siddarthan Venkatachalam

    Full Text Available Mesoscale variability and associated eddy fluxes play crucial roles in ocean circulation dynamics and the ecology of the upper ocean. In doing so, these features are biologically important, providing a mechanism for the mixing and exchange of nutrients and biota within the ocean. Transient mesoscale eddies in the Southern Ocean are known to relocate zooplankton communities across the Antarctic Circumpolar Current (ACC and are important foraging grounds for marine top predators. In this study we investigated the role of cyclonic and anti-cyclonic eddies formed at the South-West Indian Ridge on the spatial variability and diversity of microbial communities. We focused on two contrasting adjacent eddies within the Antarctic Polar Frontal Zone to determine how these features may influence the microbial communities within this region. The water masses and microbiota of the two eddies, representative of a cyclonic cold core from the Antarctic zone and an anti-cyclonic warm-core from the Subantarctic zone, were compared. The data reveal that the two eddies entrain distinct microbial communities from their points of origin that are maintained for up to ten months. Our findings highlight the ecological impact that changes, brought by the translocation of eddies across the ACC, have on microbial diversity.

  9. Toward Understanding the Role of Aryl Hydrocarbon Receptor in the Immune System: Current Progress and Future Trends

    Directory of Open Access Journals (Sweden)

    Hamza Hanieh

    2014-01-01

    Full Text Available The immune system is regulated by distinct signaling pathways that control the development and function of the immune cells. Accumulating evidence suggest that ligation of aryl hydrocarbon receptor (Ahr, an environmentally responsive transcription factor, results in multiple cross talks that are capable of modulating these pathways and their downstream responsive genes. Most of the immune cells respond to such modulation, and many inflammatory response-related genes contain multiple xenobiotic-responsive elements (XREs boxes upstream. Active research efforts have investigated the physiological role of Ahr in inflammation and autoimmunity using different animal models. Recently formed paradigm has shown that activation of Ahr by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or 3,3′-diindolylmethane (DIM prompts the differentiation of CD4+Foxp3+ regulatory T cells (Tregs and inhibits T helper (Th-17 suggesting that Ahr is an innovative therapeutic strategy for autoimmune inflammation. These promising findings generate a basis for future clinical practices in humans. This review addresses the current knowledge on the role of Ahr in different immune cell compartments, with a particular focus on inflammation and autoimmunity.

  10. Federal Aid and State Library Agencies.

    Science.gov (United States)

    Shavit, David

    1985-01-01

    Considers role of states as middlemen between federal government and local public libraries in administration of Library Services and Construction Act funds. An audit of Illinois state library agencies, 1970 federal mandates, state control of federal funds, and state library agencies' use of funds are discussed. Eight references are cited. (EJS)

  11. Federalism and managed care: introductory comments to the American Association of Law Schools' Section on Law, Medicine and Health Care on the role of the states in managed care regulation.

    Science.gov (United States)

    Blum, J D

    1999-01-01

    This section of the Annals of Health Law represents a compilation of materials concerning the state regulation of managed care. The following materials were first presented at the annual meeting of the American Association of Law Schools ("AALS"), Section on Law, Medicine and Health Care in January 1999. Chairman John Blum introduces the subject and questions the dual role assumed by state and federal authorities in regulating managed care.

  12. Current Understanding of Physicochemical Mechanisms for Cell Membrane Penetration of Arginine-rich Cell Penetrating Peptides: Role of Glycosaminoglycan Interactions.

    Science.gov (United States)

    Takechi-Haraya, Yuki; Saito, Hiroyuki

    2018-01-01

    Arginine-rich cell penetrating peptides (CPPs) are very promising drug carriers to deliver membrane-impermeable pharmaceuticals, such as siRNA, bioactive peptides and proteins. CPPs directly penetrate into cells across cell membranes via a spontaneous energy-independent process, in which CPPs appear to interact with acidic lipids in the outer leaflet of the cell membrane. However, acidic lipids represent only 10 to 20% of the total membrane lipid content and in mammalian cell membranes they are predominantly located in the inner leaflet. Alternatively, CPPs favorably bind in a charge density- dependent manner to negatively charged, sulfated glycosaminoglycans (GAGs), such as heparan sulfate and chondroitin sulfate, which are abundant on the cell surface and are involved in many biological functions. We have recently demonstrated that the interaction of CPPs with sulfated GAGs plays a critical role in their direct cell membrane penetration: the favorable enthalpy contribution drives the high-affinity binding of arginine-rich CPPs to sulfated GAGs, initiating an efficient cell membrane penetration. The favorable enthalpy gain is presumably mainly derived from a unique property of the guanidino group of arginine residues forming multidentate hydrogen bonding with sulfate and carboxylate groups in GAGs. Such interactions can be accompanied with charge neutralization of arginine-rich CPPs, promoting their partition into cell membranes. This review summarizes the current understanding of the physicochemical mechanism for lipid membrane penetration of CPPs, and discusses the role of the GAG interactions on the cell membrane penetration of CPPs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  13. Biphasic response of action potential duration to metabolic inhibition in rabbit and human ventricular myocytes: role of transient outward current and ATP-regulated potassium current

    NARCIS (Netherlands)

    Verkerk, A. O.; Veldkamp, M. W.; van Ginneken, A. C.; Bouman, L. N.

    1996-01-01

    Inhibition of cell metabolism is associated with significant changes in action potential duration. The aim of this study was to investigate the time course of the changes in action potential duration during metabolic inhibition and to determine what changes in membrane currents are responsible. The

  14. Why the Federal Reserve Failed to See the Financial Crisis of 2008: The Role of “Macroeconomics” as a Sense making and Cultural Frame

    OpenAIRE

    Fligstein, Neil; Brundage, Jonah S; Schultz, Michael

    2014-01-01

    One of the puzzles about the financial crisis of 2008 is why the regulators were so slow to recognize the impending collapse of the financial system. In this paper, we propose a novel account of what happened. We analyze the meeting transcripts of the Federal Reserve’s main decision-making body, the Federal Open Market Committee (FOMC), to show that they had surprisingly little recognition that a serious economic meltdown was underway even after the collapse of Lehman Brothers on September 15...

  15. Proceedings of the DOE workshop on the role of a high-current accelerator in the future of nuclear medicine

    International Nuclear Information System (INIS)

    Moody, D.C.; Peterson, E.J.

    1989-05-01

    The meeting was prompted by recent problems with isotope availability from DOE accelerator facilities; these difficulties have resulted from conflicting priorities between physics experiments and isotope production activities. The workshop was a forum in which the nuclear medicine community, isotope producers, industry, and other interested groups could discuss issues associated with isotope availability (including continuous supply options), the role of DOE and industry in isotope production, and the importance of research isotopes to the future of nuclear medicine. The workshop participants endorsed DOE's presence in supplying radioisotopes for research purposes and recommended that DOE should immediately provide additional support for radionuclide production in the form of personnel and supplies, DOE should establish a policy that would allow income from sales of future ''routine'' radionuclide production to be used to support technicians, DOE should obtain a 70-MeV, 500-/mu/A variable-energy proton accelerator as soon as possible, and DOE should also immediately solicit proposals to evaluate the usefulness of a new or upgraded high-energy, high-current machine for production of research radionuclides. This proceedings volume is a summary of workshop sessions that explored the future radionuclide needs of the nuclear medicine community and discussed the DOE production capabilities that would be required to meet these needs

  16. Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons

    Directory of Open Access Journals (Sweden)

    Yimy eAmarillo

    2015-05-01

    Full Text Available Thalamocortical neurons are involved in the generation and maintenance of brain rhythms associated with global functional states. The repetitive burst firing of TC neurons at delta frequencies (1-4 Hz has been linked to the oscillations recorded during deep sleep and during episodes of absence seizures. To get insight into the biophysical properties that are the basis for intrinsic delta oscillations in these neurons, we performed a bifurcation analysis of a minimal conductance-based thalamocortical neuron model including only the IT channel and the sodium and potassium leak channels. This analysis unveils the dynamics of repetitive burst firing of TC neurons, and describes how the interplay between the amplifying variable mT and the recovering variable hT of the calcium channel IT is sufficient to generate low threshold oscillations in the delta band. We also explored the role of the hyperpolarization activated cationic current Ih in this reduced model and determine that, albeit not required, Ih amplifies and stabilizes the oscillation.

  17. Proceedings of the DOE workshop on the role of a high-current accelerator in the future of nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    Moody, D.C.; Peterson, E.J. (comps.)

    1989-05-01

    The meeting was prompted by recent problems with isotope availability from DOE accelerator facilities; these difficulties have resulted from conflicting priorities between physics experiments and isotope production activities. The workshop was a forum in which the nuclear medicine community, isotope producers, industry, and other interested groups could discuss issues associated with isotope availability (including continuous supply options), the role of DOE and industry in isotope production, and the importance of research isotopes to the future of nuclear medicine. The workshop participants endorsed DOE's presence in supplying radioisotopes for research purposes and recommended that DOE should immediately provide additional support for radionuclide production in the form of personnel and supplies, DOE should establish a policy that would allow income from sales of future ''routine'' radionuclide production to be used to support technicians, DOE should obtain a 70-MeV, 500-/mu/A variable-energy proton accelerator as soon as possible, and DOE should also immediately solicit proposals to evaluate the usefulness of a new or upgraded high-energy, high-current machine for production of research radionuclides. This proceedings volume is a summary of workshop sessions that explored the future radionuclide needs of the nuclear medicine community and discussed the DOE production capabilities that would be required to meet these needs.

  18. The role of European Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase in standardization and harmonization of the preanalytical phase in Europe

    NARCIS (Netherlands)

    Cornes, Michael P.; Church, Stephen; van Dongen-Lases, Edmée; Grankvist, Kjell; Guimarães, João T.; Ibarz, Mercedes; Kovalevskaya, Svetlana; Kristensen, Gunn Bb; Lippi, Giuseppe; Nybo, Mads; Sprongl, Ludek; Sumarac, Zorica; Simundic, Ana-Maria

    2016-01-01

    Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry and

  19. Federal laboratories for the 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Gover, J. [Sandia National Labs., Albuquerque, NM (United States); Huray, P.G. [Univ. of South Carolina, Columbia, SC (United States)

    1998-04-01

    Federal laboratories have successfully filled many roles for the public; however, as the 21st Century nears it is time to rethink and reevaluate how Federal laboratories can better support the public and identify new roles for this class of publicly-owned institutions. The productivity of the Federal laboratory system can be increased by making use of public outcome metrics, by benchmarking laboratories, by deploying innovative new governance models, by partnerships of Federal laboratories with universities and companies, and by accelerating the transition of federal laboratories and the agencies that own them into learning organizations. The authors must learn how government-owned laboratories in other countries serve their public. Taiwan`s government laboratory, Industrial Technology Research Institute, has been particularly successful in promoting economic growth. It is time to stop operating Federal laboratories as monopoly institutions; therefore, competition between Federal laboratories must be promoted. Additionally, Federal laboratories capable of addressing emerging 21st century public problems must be identified and given the challenge of serving the public in innovative new ways. Increased investment in case studies of particular programs at Federal laboratories and research on the public utility of a system of Federal laboratories could lead to increased productivity of laboratories. Elimination of risk-averse Federal laboratory and agency bureaucracies would also have dramatic impact on the productivity of the Federal laboratory system. Appropriately used, the US Federal laboratory system offers the US an innovative advantage over other nations.

  20. Federalism and bioethics.

    Science.gov (United States)

    Von Hagel, Alisa

    2014-01-01

    The absence of comprehensive federal oversight of human biotechnologies in the United States continues to stimulate academic discourse on the relative merits of European-style regulatory agencies as compared to the current, decentralized approach. Many American bioethicists support the latter, maintaining that the key features of federalism--policy experimentation and moral pluralism--allows for the efficient regulation of these complex and contentious issues. This paper examines state-level regulation of oocyte donation to assess claims regarding the superiority of this decentralized regulatory approach. Further, this paper introduces an additional element to this examination of state law, which concerns the degree to which the health and safety of key participants is addressed at the state level. This inquiry assesses one facet of fertility medicine and biomedical research law, oocyte donation, an analysis that can be used to inform the broader discourse regarding the regulation of human biotechnologies and bioethical issues by the states.

  1. Role of amino acid supplementation in the prevention of necrotizing enterocolitis in preterm neonates - a review of current evidences.

    Science.gov (United States)

    Garg, Bhawan Deep; Kabra, Nandkishor S

    2018-09-01

    Necrotizing enterocolitis (NEC) is one of the most common acute and fatal gastrointestinal emergency in very low birth weight (VLBW) preterm neonates with mortality range from 15 to 30%. NEC is likely due to multifactorial process such as oxidative injury, ischemic necrosis, and over-reactive inflammatory response to intestinal microbes. To evaluate the role of amino acid supplementation for reduction of neonatal NEC in preterm neonates. The literature search was done for various randomized control trial (RCT) by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, Scopus, Index Copernicus, African Index Medicus (AIM), Thomson Reuters (ESCI), Chemical Abstracts Service (CAS) and other database. This review included 15 RCTs that fulfilled inclusion criteria. The total neonates enrolled in these different RCT are 3424 (amino acid group 1711 and control 1713). Almost all participating neonates were of VLBW or extremely low birth weight (ELBW). In two trials, birth weight was between 1500-2000 grams. The intervention was started within first few days after birth and continued up to 30th day of postnatal age in most of the trials. In two trials, intervention was continued up to 120th day of postnatal age. Arginine, glutamine and N-acetyl cysteine (NAC) were used at the dose of 1.5 mol/kg/day (261 mg/kg/day), 0.3 grams/kg/day and 16-32 mg/kg/day, respectively. Role of amino acid in the prevention of neonatal NEC is not exclusively supported by the current evidence. Only three studies were able to show reduction in the incidence of NEC with amino acid supplementation (arginine, glutamine), and the remaining studies did not report any positive effect. Amino acid supplementation was not associated with significant reduction in mortality due to any causes. However, arginine supplementation was associated with significant reduction in mortality due to NEC. Two studies on glutamine were reported significant reduction in

  2. Role of the community pharmacist in emergency contraception counseling and delivery in the United States: current trends and future prospects

    Directory of Open Access Journals (Sweden)

    Rafie S

    2017-03-01

    Full Text Available Sally Rafie,1 Rebecca H Stone,2 Tracey A Wilkinson,3 Laura M Borgelt,4,5 Shareen Y El-Ibiary,6 Denise Ragland7 1Department of Pharmacy, UC San Diego Health, San Diego, CA, 2Department of Clinical and Administrative Pharmacy, University of Georgia, College of Pharmacy, Athens, GA, 3Children’s Health Services Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 4Department of Clinical Pharmacy, 5Department of Family Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, 6Department of Pharmacy Practice, College of Pharmacy, Midwestern University, Glendale, AZ, 7Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, USA Abstract: Women and couples continue to experience unintended pregnancies at high rates. In the US, 45% of all pregnancies are either mistimed or unwanted. Mishaps with contraceptives, such as condom breakage, missed pills, incorrect timing of patch or vaginal ring application, contraceptive nonuse, forced intercourse, and other circumstances, place women at risk of unintended pregnancy. There is a critical role for emergency contraception (EC in preventing those pregnancies. There are currently three methods of EC available in the US. Levonorgestrel EC pills have been available with a prescription for over 15 years and over-the-counter since 2013. In 2010, ulipristal acetate EC pills became available with a prescription. Finally, the copper intrauterine device remains the most effective form of EC. Use of EC is increasing over time, due to wider availability and accessibility of EC methods. One strategy to expand access for both prescription and nonprescription EC products is to include pharmacies as a point of access and allow pharmacist prescribing. In eight states, pharmacists are able to prescribe and provide EC directly to women: levonorgestrel EC in eight states and ulipristal

  3. The Breakdown Mechanisms In Electrical Discharges: The Role Of The Field Emission Effect In Direct Current Discharges In Micro gaps

    International Nuclear Information System (INIS)

    Radmilovic-Radjenovic, M.; Radjenovic, B.; Bojarov, A.; Klas, M.; Matejcik, S.

    2013-01-01

    This review represents an attempt to sum up the current state of the research in the field of breakdown phenomena in electrical discharges. The paper provides facts and theories concerning different classes of direct current, radio and microwave frequency discharges, in vacuum, in the gas and in liquids, without and in the presence of the magnetic fields. The emphasize was made on the field emission effects and on the fundamental aspects of the breakdown phenomena in micro discharges via discussions and analysis of the experimental, theoretical and simulation results. It was found that the Paschen's law is not applicable for the micron gap sizes, when deviations from the standard scaling law become evident and modified Paschen curve should be used. The explanation of the deviations from the Paschen law was attributed to the secondary electron emission enhanced by the strong field generated in micro gaps. The experiments were carried out in order to establish scaling law in micro gaps. The volt-ampere characteristics were also recorded and compared with the theoretical predictions based on the Fowler-Nordheim theory. The importance of the enhancement factor and the space charge on results was also considered. On the basis of the experimental breakdown voltage curves, the effective yields in micro gaps have been estimated for different gases which can be served as input data in modeling. The effective yields allow analytically produce modified Paschen curves that predicts the deviations from the Paschen law observed in the experiments. In addition, we present results of computer simulations using a Particle-in-cell/Monte Carlo Collisions (PIC/MCC) code with the secondary emission model in order to include the field emission enhanced secondary electron production in micro gaps. The agreement between simulation and experimental results suggest that computer simulations can be used to improve understanding of the plasma physics as an alternative to analytical

  4. The role of minimum supply and social vulnerability assessment for governing critical infrastructure failure: current gaps and future agenda

    Directory of Open Access Journals (Sweden)

    M. Garschagen

    2018-04-01

    Full Text Available Increased attention has lately been given to the resilience of critical infrastructure in the context of natural hazards and disasters. The major focus therein is on the sensitivity of critical infrastructure technologies and their management contingencies. However, strikingly little attention has been given to assessing and mitigating social vulnerabilities towards the failure of critical infrastructure and to the development, design and implementation of minimum supply standards in situations of major infrastructure failure. Addressing this gap and contributing to a more integrative perspective on critical infrastructure resilience is the objective of this paper. It asks which role social vulnerability assessments and minimum supply considerations can, should and do – or do not – play for the management and governance of critical infrastructure failure. In its first part, the paper provides a structured review on achievements and remaining gaps in the management of critical infrastructure and the understanding of social vulnerabilities towards disaster-related infrastructure failures. Special attention is given to the current state of minimum supply concepts with a regional focus on policies in Germany and the EU. In its second part, the paper then responds to the identified gaps by developing a heuristic model on the linkages of critical infrastructure management, social vulnerability and minimum supply. This framework helps to inform a vision of a future research agenda, which is presented in the paper's third part. Overall, the analysis suggests that the assessment of socially differentiated vulnerabilities towards critical infrastructure failure needs to be undertaken more stringently to inform the scientifically and politically difficult debate about minimum supply standards and the shared responsibilities for securing them.

  5. The role of minimum supply and social vulnerability assessment for governing critical infrastructure failure: current gaps and future agenda

    Science.gov (United States)

    Garschagen, Matthias; Sandholz, Simone

    2018-04-01

    Increased attention has lately been given to the resilience of critical infrastructure in the context of natural hazards and disasters. The major focus therein is on the sensitivity of critical infrastructure technologies and their management contingencies. However, strikingly little attention has been given to assessing and mitigating social vulnerabilities towards the failure of critical infrastructure and to the development, design and implementation of minimum supply standards in situations of major infrastructure failure. Addressing this gap and contributing to a more integrative perspective on critical infrastructure resilience is the objective of this paper. It asks which role social vulnerability assessments and minimum supply considerations can, should and do - or do not - play for the management and governance of critical infrastructure failure. In its first part, the paper provides a structured review on achievements and remaining gaps in the management of critical infrastructure and the understanding of social vulnerabilities towards disaster-related infrastructure failures. Special attention is given to the current state of minimum supply concepts with a regional focus on policies in Germany and the EU. In its second part, the paper then responds to the identified gaps by developing a heuristic model on the linkages of critical infrastructure management, social vulnerability and minimum supply. This framework helps to inform a vision of a future research agenda, which is presented in the paper's third part. Overall, the analysis suggests that the assessment of socially differentiated vulnerabilities towards critical infrastructure failure needs to be undertaken more stringently to inform the scientifically and politically difficult debate about minimum supply standards and the shared responsibilities for securing them.

  6. Federal research

    International Nuclear Information System (INIS)

    1991-04-01

    This book reviews the status of the Department of Energy's (DOE) Superconducting Super Collider (SSC), which will be located 30 miles south of Dallas, Texas. The SSC will be the world's largest high energy particle accelerator a research tool used by physicists to seek fundamental knowledge about energy and matter. DOE recently estimated that the SSC will cost $8.2 billion (in current-year dollars). This report provides information on the instability in tenure of DOE and SSC Laboratory project management, uncertainties related to the SSC site geology, uncertainties and risks with magnet development and production, and Texas' proposed contribution to the project's costs

  7. A brief history of federal support for health physics education and training in the United States

    International Nuclear Information System (INIS)

    Ziemer, P.L.

    1996-01-01

    Since the formation of health physics as a profession following the end of World War II, the federal government of the United States has played an active role in the support of education and training of health physicists. The purpose of this paper is to review the types of federal support that have been available from the federal government in the past and to examine the current status of support. Individuals trained in health physics through the nuclear navy programs have not been included in this discussion. (author)

  8. Vorapaxar: The Current Role and Future Directions of a Novel Protease-Activated Receptor Antagonist for Risk Reduction in Atherosclerotic Disease

    OpenAIRE

    Gryka, Rebecca J.; Buckley, Leo F.; Anderson, Sarah M.

    2017-01-01

    Introduction Despite the current standard of care, patients with cardiovascular disease remain at a high risk for recurrent events. Inhibition of thrombin-mediated platelet activation through protease-activated receptor-1 antagonism may provide reductions in atherosclerotic disease beyond those achievable with the current standard of care. Objective Our primary objective is to evaluate the clinical literature regarding the role of vorapaxar (Zontivity?) in the reduction of cardiovascular even...

  9. Federal research

    International Nuclear Information System (INIS)

    1991-05-01

    This paper reports that of the uncertainties and risks associated with the construction of the superconducting super collider, the major technical risk concerns the collider dipole magnets. Although Germany has demonstrated that superconducting magnets can be industrially produced, their magnets were made for a substantially smaller accelerator and involved different management approaches. Whether the superconducting super collider's magnets will work as intended is uncertain because no full-size magnet of the current design has been built and tested. Although the Department of Energy has tried to reduce the risk by, among other things, delaying the start of magnet production, uncertainties and risks remain. The schedule for developing the magnets is still compressed and the overall risks for the magnets are high because little time will be available to resolve any problems that may be encountered. A critical test in determining whether the magnets will work as intended is the aboveground string test scheduled for the fourth quarter of fiscal year 1992. Tunnel construction is also scheduled to start in the fourth quarter of that fiscal year. In April 1991, GAO suggested that Congress could limit the government's financial risk by not funding tunnel construction until the string tests have shown that the magnets work as intended

  10. Can Brazil play a more important role in global tuberculosis drug production? An assessment of current capacity and challenges.

    Science.gov (United States)

    Gemal, Andre; Keravec, Joel; Menezes, Alexandre; Trajman, Anete

    2013-03-27

    Despite the existence of effective treatment, tuberculosis is still a global public health issue. The World Health Organization recommends a six-month four-drug regimen in fixed-dose combination formulation to treat drug sensitive tuberculosis, and long course regimens with several second-line drugs to treat multi-drug resistant tuberculosis. To achieve the projected tuberculosis elimination goal by 2050, it will be essential to ensure a non-interrupted supply of quality-assured tuberculosis drugs. However, quality and affordable tuberculosis drug supply is still a significant challenge for National Tuberculosis Programs. Quality drug production requires a combination of complex steps. The first challenge is to guarantee the quality of tuberculosis active pharmaceutical ingredients, then ensure an adequate manufacturing process, according to international standards, to guarantee final product's safety, efficacy and quality. Good practices for storage, transport, distribution and quality control procedures must follow. In contrast to other high-burden countries, Brazil produces tuberculosis drugs through a strong network of public sector drug manufacturers regulated by a World Health Organization-certified national sanitary authority. The installed capacity for production surpasses the 71,000 needed treatments in the country. However, in order to be prepared to act as a global supplier, important bottlenecks are to be overcome. This article presents an in-depth analysis of the current status of production of tuberculosis drugs in Brazil and the bottlenecks and opportunities for the country to sustain national demand and play a role as a potential global supplier. Raw material and drug production, quality control, international certification and pre-qualification, political commitment and regulatory aspects are discussed, as well recommendations for tackling these bottlenecks. This discussion becomes more important as new drugs and regimens to treat tuberculosis are

  11. Health care reform and federalism.

    Science.gov (United States)

    Greer, Scott L; Jacobson, Peter D

    2010-04-01

    Health policy debates are replete with discussions of federalism, most often when advocates of reform put their hopes in states. But health policy literature is remarkably silent on the question of allocation of authority, rarely asking which levels of government ought to lead. We draw on the larger literatures about federalism, found mostly in political science and law, to develop a set of criteria for allocating health policy authority between states and the federal government. They are social justice, procedural democracy, compatibility with value pluralism, institutional capability, and economic sustainability. Of them, only procedural democracy and compatibility with value pluralism point to state leadership. In examining these criteria, we conclude that American policy debates often get federalism backward, putting the burden of health care coverage policy on states that cannot enact or sustain it, while increasing the federal role in issues where the arguments for state leadership are compelling. We suggest that the federal government should lead present and future financing of health care coverage, since it would require major changes in American intergovernmental relations to make innovative state health care financing sustainable outside a strong federal framework.

  12. The current and future role of general practitioners in skin cancer care: an assessment of 268 general practitioners

    NARCIS (Netherlands)

    Rijsingen, M.C.J. van; Bon, B.W. van; Wilt, G.J. van der; Lagro-Janssen, A.L.M.; Gerritsen, M.J.P.

    2014-01-01

    BACKGROUND: Given the increase in skin cancer (SC) it seems inevitable that general practitioners (GPs) will play a larger role in SC care in the near future. OBJECTIVES: To obtain insights into the opinion of GPs with respect to their role in SC care, and their SC knowledge and skills. METHODS: A

  13. Energy transport corridors: the potential role of Federal lands in states identified by the Energy Policy Act of 2005, section 368(b).

    Energy Technology Data Exchange (ETDEWEB)

    Krummel, J.; Hlohowskyj, I.; Kuiper, J.; Kolpa, R.; Moore, R.; May, J.; VanKuiken, J.C.; Kavicky, J.A.; McLamore, M.R.; Shamsuddin, S. (Decision and Information Sciences); ( EVS)

    2011-09-01

    On August 8, 2005, the President signed the Energy Policy Act of 2005 (EPAct) into law. In Subtitle F of EPAct, Congress set forth various provisions that would change the way certain federal agencies (Agencies) coordinate to authorize the use of land for a variety of energy-related purposes. As part of Subtitle F of EPAct, Section 368 addresses the issue of energy transportation corridors on federal land for oil, gas, and hydrogen pipelines, as well as electricity transmission and distribution facilities. Because of the critical importance of improving the nation's electrical transmission grid, Congress recognized that electricity transmission issues should receive added attention when the Agencies address corridor location and analysis issues. In Section 368, Congress specifically directed the Agencies to consider the need for upgraded and new facilities to deliver electricity: In carrying out [Section 368], the Secretaries shall take into account the need for upgraded and new electricity transmission and distribution facilities to (1) improve reliability; (2) relieve congestion; and (3) enhance capability of the national grid to deliver electricity. Section 368 does not require the Agencies to consider or approve specific projects, applications for rights-of-way (ROWs), or other permits within designated energy corridors. Importantly, Section 368 does not direct, license, or otherwise permit any on-the-ground activity of any sort. If an applicant is interested in obtaining an authorization to develop a project within any corridor designated under Section 368, the applicant would have to apply for a ROW authorization and applicable permits. The Agencies would consider each application by applying appropriate project-specific reviews under requirements of laws and related regulations, including, but not limited to, the National Environmental Policy Act (NEPA), the Clean Water Act, the Clean Air Act, Section 7 of the Endangered Species Act (ESA), and Section

  14. Ronald Reagan's "New Federalism."

    Science.gov (United States)

    Parker, Joseph B.

    1982-01-01

    Describes how changes in federal fiscal policies affect the federal government's relationship to state and local government. Franklin D. Roosevelt's and Ronald Reagan's formulas for "New Federalism" are compared. (AM)

  15. The role of European Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase in standardization and harmonization of the preanalytical phase in Europe

    DEFF Research Database (Denmark)

    Cornes, Michael P; Church, Stephen; van Dongen-Lases, Edmée

    2016-01-01

    Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry and Labor......Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry...... and Laboratory Medicine Working Group for Preanalytical Phase (EFLM WG-PRE) was established to lead in standardization and harmonization of preanalytical policies and practices at a European level. One of the key activities of the WG-PRE is the organization of the biennial EFLM-BD conference on the preanalytical...... summarises the work that has and will be done in these areas. The goal of this initiative is to ensure the EFLM WG-PRE produces work that meets the needs of the European laboratory medicine community. Progress made in the identified areas will be updated at the next preanalytical phase conference and show...

  16. Brachytherapy, diagnostic radiology, mammographic radiology and ophthalmic applicators. An assessment of current and future needs in the UK and the role of NPL

    International Nuclear Information System (INIS)

    Angliss, R.; Bass, G.; Sander, T.

    2001-01-01

    Several UK hospitals were visited by NPL staff to discuss the current practises and future developments in brachytherapy, diagnostic and mammographic radiology and ophthalmic applicators. The results of the discussions are presented here, including NPL's role in each of these areas is discussed. (author)

  17. The O+ contribution and role on the ring current pressure development for CMEs and CIRs using Van Allen Probes observations

    Science.gov (United States)

    Mouikis, C.; Bingham, S.; Kistler, L. M.; Farrugia, C. J.; Spence, H. E.; Gkioulidou, M.

    2016-12-01

    The ring current responds differently to the different solar and interplanetary storm drivers such as coronal mass injections, (CME's), co-rotating interaction regions (CIR's), high-speed streamers and other structures. The resulting changes in the ring current particle pressure change the global magnetic field, which affects the transport of the radiation belts. In order to determine the field changes during a storm, it is necessary to understand the transport, sources and losses of the particles that contribute to the ring current. The source population of the storm time ring current is the night side plasma sheet. We use Van Allen Probes observations to determine the ring current pressure contribution of the convecting plasma sheet H+ and O+ particles in the storm time development of the ring current. We compare storms that are related to different interplanetary drivers, CMEs and CIRs, as observed at different local times. We find that during the storm main phase most of the ring current pressure in the pre-midnight inner magnetosphere is contributed by particles on open drift paths that cause the development of a strong partial ring current that causes most of the main phase Dst drop. These particles can reach as deep as L 2 and their pressure compares to the local magnetic field pressure as deep as L 3. During the recovery phase, if these particles are not lost at the magnetopause, will become trapped and will contribute to the symmetric ring current. However, the largest difference between the CME and CIR ring current responses during the storm main and early recovery phases is caused by how the 15 - 60 keV O+ responds to these drivers.

  18. Current temporal asymmetry and the role of tides: Nan-Wan Bay vs. the Gulf of Elat

    Science.gov (United States)

    Ashkenazy, Yosef; Fredj, Erick; Gildor, Hezi; Gong, Gwo-Ching; Lee, Hung-Jen

    2016-05-01

    Nan-Wan Bay in Taiwan and the Gulf of Elat in Israel are two different coastal environments, and as such, their currents are expected to have different statistical properties. While Nan-Wan Bay is shallow, has three open boundaries, and is directly connected to the open ocean, the Gulf of Elat is deep, semi-enclosed, and connected to the Red Sea via the Straits of Tiran. Surface currents have been continuously measured with fine temporal (less than or equal to 1 h) and spatial resolution (less than or equal to 1 km) for more than a year in both environments using coastal radars (CODARs) that cover a domain of roughly 10 × 10 km. These measurements show that the currents in Nan-Wan Bay are much stronger than those in the Gulf of Elat and that the mean current field in Nan-Wan Bay exhibits cyclonic circulation, which is stronger in the summer; in the Gulf of Elat, the mean current field is directed southward and is also stronger during the summer. We have compared the statistical properties of the current speeds in both environments and found that both exhibit large spatial and seasonal variations in the shape parameter of the Weibull distribution. However, we have found fundamental and significant differences when comparing the temporal asymmetry of the current speed (i.e., the ratio between the time during which the current speed increases and the total time). While the Nan-Wan Bay currents are significantly asymmetric, those of the Gulf of Elat are not. We then extracted the tidal component of the Nan-Wan Bay currents and found that it is strongly asymmetric, while the asymmetry of tidally filtered currents is much weaker. We thus conclude that the temporal asymmetry of the Nan-Wan Bay currents reported here is due to the strong tides in the region. We show that the asymmetry ratio in Nan-Wan Bay varies spatially and seasonally: (i) the currents increase rapidly and decay slowly in the northern part of the domain and vice versa in the southern part, and (ii) the

  19. A Survey of University of Medical Sciences’ Health Care Professionals on the Current and Ideal Role of General Practitioners in Iran

    Directory of Open Access Journals (Sweden)

    Bijan Geraili

    2009-08-01

    Full Text Available Background and purpose: roles and tasks of intended graduates direct medical eductionist for developing the right curriculum. In Iran there has been no systematic study on defining GPs roles. This study is an attempt to systematically clarify the roles of GPs in Iran.Methods: In this questionnaire – based survey health care professionals participated. The subjects were selected through convinient sampling and snowballing. A semi-structured questionnaire was developed which covered the goals and functions of health system as mentioned in World Health Report 2000. For content validity a panel of experts including health care professionals, biostatisticians, and psychometrist evaluated the questionnaire. For the reliability of the questionnaire a pilot study was carried out. Chronbach’s coeficient were calculated as 0.89 .The final revision of the questionnaire included 15 roles in current and ideal states. The respondent should score each role in both states in a range of 0-100.Results: Of 50 subjects who received the questionnaire, 40 (80% completed and returned it. Of all subjects 30% were female and 70% were male. Of all subjects 90% were faculty members. The subjects believe that in the current state “health care provision” (74.7.3±29.7 “health center administration” (37±21.8, and “leading clinical services and coordinating patients care” (29.5±24.4 are more evident while “fund holding” is rather non-existence (1.2±3.7. They believed that in an ideal national health system physicians should play most of these roles in various extents.Conclusion: The participants believed that GPs should play other roles beyond the clinical care provision to enable health system respond to community needs and expectations. The graduate medical degree should be reformed if the gradates are going to play these new roles.Key words: Role Definition, Curriculum Development, GP, Primary Health Care

  20. 20 CFR 661.110 - What is the role of the Department of Labor as the Federal governmental partner in the governance...

    Science.gov (United States)

    2010-04-01

    ... local governments. (b) The Department of Labor sees as one of its primary roles providing leadership and... provisions. State and local policies, interpretations, guidelines and definitions that are consistent with...

  1. 76 FR 15044 - Federal Interagency Committee on Emergency Medical Service (FICEMS) Teleconference Meeting

    Science.gov (United States)

    2011-03-18

    ... stakeholder input call-in session to receive input regarding the current and future role of the Federal... for EMS. The National Security Staff Resilience Directorate has requested that FICEMS engage with stakeholders and develop an options paper by May 15, 2011. FICEMS is interested in any stakeholder input about...

  2. The Netherlands: How the interplay between federations and government helps to build a sporting nation

    NARCIS (Netherlands)

    Breedveld, K.; Hoekman, R.H.A.; Scheerder, J.; Willem, A.; Claes, E.

    2017-01-01

    In this chapter, we will highlight the current state of affairs as well as the historical background of the way in which sport is governed in the Netherlands. In order to do so, we will focus on the role of the national government, the sports clubs and sport federations and the local governments. We

  3. The role of ocean currents in the temperature selection of plankton : Insights from an individual-based model

    NARCIS (Netherlands)

    Hellweger, Ferdi L.; Van Sebille, Erik; Calfee, Benjamin C.; Chandler, Jeremy W.; Zinser, Erik R.; Swan, Brandon K.; Fredrick, Neil D.

    2016-01-01

    Biogeography studies that correlate the observed distribution of organisms to environmental variables are typically based on local conditions. However, in cases with substantial translocation, like planktonic organisms carried by ocean currents, selection may happen upstream and local environmental

  4. Role of Ga vacancies in enhancing the leakage current of GaN Schottky barrier ultraviolet photodetectors

    International Nuclear Information System (INIS)

    De-Gang, Zhao; Shuang, Zhang; Wen-Bao, Liu; De-Sheng, Jiang; Jian-Jun, Zhu; Zong-Shun, Liu; Hui, Wang; Shu-Ming, Zhang; Hui, Yang; Xiao-Peng, Hao; Long, Wei

    2010-01-01

    The leakage current of GaN Schottky barrier ultraviolet photodetectors is investigated. It is found that the photodetectors adopting undoped GaN instead of lightly Si-doped GaN as an active layer show a much lower leakage current even when they have a higher dislocation density. It is also found that the density of Ga vacancies in undoped GaN is much lower than in Si-doped GaN. The Ga vacancies may enhance tunneling and reduce effective Schottky barrier height, leading to an increase of leakage current. It suggests that when undoped GaN is used as the active layer, it is necessary to reduce the leakage current of GaN Schottky barrier ultraviolet photodetector. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  5. Role of the magnetospheric and ionospheric currents in the generation of the equatorial scintillations during geomagnetic storms

    Directory of Open Access Journals (Sweden)

    L. Z. Biktash

    2004-09-01

    Full Text Available The equatorial ionosphere parameters, Kp, Dst, AU and AL indices characterized contribution of different magnetospheric and ionospheric currents to the H-component of geomagnetic field are examined to test the geomagnetic activity effect on the generation of ionospheric irregularities producing VLF scintillations. According to the results of the current statistical studies, one can predict near 70% of scintillations from Aarons' criteria using the Dst index, which mainly depicts the magnetospheric ring current field. To amplify Aarons' criteria or to propose new criteria for predicting scintillation characteristics is the question. In the present phase of the experimental investigations of electron density irregularities in the ionosphere new ways are opened up because observations in the interaction between the solar wind - magnetosphere - ionosphere during magnetic storms have progressed greatly. According to present view, the intensity of the electric fields and currents at the polar regions, as well as the magnetospheric ring current intensity, are strongly dependent on the variations of the interplanetary magnetic field. The magnetospheric ring current cannot directly penetrate the equatorial ionosphere and because of this difficulties emerge in explaining its relation to scintillation activity. On the other hand, the equatorial scintillations can be observed in the absence of the magnetospheric ring current. It is shown that in addition to Aarons' criteria for the prediction of the ionospheric scintillations, models can be used to explain the relationship between the equatorial ionospheric parameters, h'F, foF2, and the equatorial geomagnetic variations with the polar ionosphere currents and the solar wind.

  6. THE ROLE OF FAST MAGNETOSONIC WAVES IN THE RELEASE AND CONVERSION VIA RECONNECTION OF ENERGY STORED BY A CURRENT SHEET

    Energy Technology Data Exchange (ETDEWEB)

    Longcope, D. W.; Tarr, L. [Department of Physics, Montana State University, Bozeman, MT 59717 (United States)

    2012-09-10

    Using a simple two-dimensional, zero-{beta} model, we explore the manner by which reconnection at a current sheet releases and dissipates free magnetic energy. We find that only a small fraction (3%-11% depending on current-sheet size) of the energy is stored close enough to the current sheet to be dissipated abruptly by the reconnection process. The remaining energy, stored in the larger-scale field, is converted to kinetic energy in a fast magnetosonic disturbance propagating away from the reconnection site, carrying the initial current and generating reconnection-associated flows (inflow and outflow). Some of this reflects from the lower boundary (the photosphere) and refracts back to the X-point reconnection site. Most of this inward wave energy is reflected back again and continues to bounce between X-point and photosphere until it is gradually dissipated, over many transits. This phase of the energy dissipation process is thus global and lasts far longer than the initial purely local phase. In the process, a significant fraction of the energy (25%-60%) remains as undissipated fast magnetosonic waves propagating away from the reconnection site, primarily upward. This flare-generated wave is initiated by unbalanced Lorentz forces in the reconnection-disrupted current sheet, rather than by dissipation-generated pressure, as some previous models have assumed. Depending on the orientation of the initial current sheet, the wave front is either a rarefaction, with backward-directed flow, or a compression, with forward-directed flow.

  7. The Role of Socio-technical Devices in Framing the Current Strategic Issues and Future States of the Service Market

    DEFF Research Database (Denmark)

    Tryggestad, Kjell

    2004-01-01

    The aim of this paper is to inquire into the role of socio-technical devices like value metrics and accounting in organizing the service market. The authors provide a case on how such devices participates in framing the market for transportation during the introduction of large-scale bridges....... In addition to the traditional role of accounting as a representation device, the authors also show how these devices participate in performing the service economy - undermining and redrawing organizational boundaries in unexpected ways. The presence of multiple connections with socio-technical devices...... are then brought into an explanation of the overflowing and reconfiguration of the transportation market....

  8. Federal Student Loan Programs

    Science.gov (United States)

    Federal Student Aid, US Department of Education, 2014

    2014-01-01

    For those needing a loan to attend college, think federal aid first. Federal student loans usually offer borrowers lower interest rates and have more flexible repayment terms and options than private student loans. This brief report answers the following questions about federal aid: (1) What is a federal student loan?; (2) What is a private…

  9. Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.

    Science.gov (United States)

    Devenyi, Ryan A; Ortega, Francis A; Groenendaal, Willemijn; Krogh-Madsen, Trine; Christini, David J; Sobie, Eric A

    2017-04-01

    Arrhythmias result from disruptions to cardiac electrical activity, although the factors that control cellular action potentials are incompletely understood. We combined mathematical modelling with experiments in heart cells from guinea pigs to determine how cellular electrical activity is regulated. A mismatch between modelling predictions and the experimental results allowed us to construct an improved, more predictive mathematical model. The balance between two particular potassium currents dictates how heart cells respond to perturbations and their susceptibility to arrhythmias. Imbalances of ionic currents can destabilize the cardiac action potential and potentially trigger lethal cardiac arrhythmias. In the present study, we combined mathematical modelling with information-rich dynamic clamp experiments to determine the regulation of action potential morphology in guinea pig ventricular myocytes. Parameter sensitivity analysis was used to predict how changes in ionic currents alter action potential duration, and these were tested experimentally using dynamic clamp, a technique that allows for multiple perturbations to be tested in each cell. Surprisingly, we found that a leading mathematical model, developed with traditional approaches, systematically underestimated experimental responses to dynamic clamp perturbations. We then re-parameterized the model using a genetic algorithm, which allowed us to estimate ionic current levels in each of the cells studied. This unbiased model adjustment consistently predicted an increase in the rapid delayed rectifier K + current and a drastic decrease in the slow delayed rectifier K + current, and this prediction was validated experimentally. Subsequent simulations with the adjusted model generated the clinically relevant prediction that the slow delayed rectifier is better able to stabilize the action potential and suppress pro-arrhythmic events than the rapid delayed rectifier. In summary, iterative coupling of

  10. The role to the citizen participation in public policies, under the current scenario of governance: theoretical reflections

    Directory of Open Access Journals (Sweden)

    Monica Castillo Cubillos

    2017-09-01

    It is necessary to involve thinking about public policy, as one of the roles in which citizens may or may not make such effective participation. Taking into account, that public policy instruments can encourage and strengthen governance, in scenarios where there is a real participation of citizens. Let us see how true this is.

  11. The Role of Ultrasound in Graduate Anatomy Education: Current State of Integration in the United States and Faculty Perceptions

    Science.gov (United States)

    Royer, Danielle F.

    2016-01-01

    Ultrasound (US) is increasingly taught in medical schools, where it has been shown to be a valuable adjunct to anatomy training. To determine the extent of US training in nonmedical anatomy programs, and evaluate anatomists' perceptions on the role of US in anatomy education, an online survey was distributed to faculty in anatomy Master's and…

  12. Understanding the impact of prior depression on stress generation: examining the roles of current depressive symptoms and interpersonal behaviours.

    Science.gov (United States)

    Shih, Josephine H; Eberhart, Nicole K

    2008-08-01

    Stress generation is a process in which individuals contribute to stressful life events. While research has supported an association between current depression and stress generation, it has been noted that individuals with prior depression tend to contribute to stressors even when they are no longer experiencing a depressive episode. The aim of the study is to elucidate the pathways through which prior major depression predicts interpersonal stress generation in women. Specifically, we examined current subsyndromal depressive symptoms and problematic interpersonal behaviours as potential mediators. Fifty-one college women were followed prospectively for 6 weeks. Participants were interviewed to assess current and past depression as well as stressful life events they experienced over the 6-week period. The findings suggest that prior major depression continues to have an impact even after the episode has ended, as the disorder continues to contribute to stress generation through residual depressive symptoms.

  13. Hyperpolarization-activated current (I(h)) in vestibular calyx terminals: characterization and role in shaping postsynaptic events.

    Science.gov (United States)

    Meredith, Frances L; Benke, Tim A; Rennie, Katherine J

    2012-12-01

    Calyx afferent terminals engulf the basolateral region of type I vestibular hair cells, and synaptic transmission across the vestibular type I hair cell/calyx is not well understood. Calyces express several ionic conductances, which may shape postsynaptic potentials. These include previously described tetrodotoxin-sensitive inward Na(+) currents, voltage-dependent outward K(+) currents and a K(Ca) current. Here, we characterize an inwardly rectifying conductance in gerbil semicircular canal calyx terminals (postnatal days 3-45), sensitive to voltage and to cyclic nucleotides. Using whole-cell patch clamp, we recorded from isolated calyx terminals still attached to their type I hair cells. A slowly activating, noninactivating current (I(h)) was seen with hyperpolarizing voltage steps negative to the resting potential. External Cs(+) (1-5 mM) and ZD7288 (100 μM) blocked the inward current by 97 and 83 %, respectively, confirming that I(h) was carried by hyperpolarization-activated, cyclic nucleotide gated channels. Mean half-activation voltage of I(h) was -123 mV, which shifted to -114 mV in the presence of cAMP. Activation of I(h) was well described with a third order exponential fit to the current (mean time constant of activation, τ, was 190 ms at -139 mV). Activation speeded up significantly (τ=136 and 127 ms, respectively) when intracellular cAMP and cGMP were present, suggesting that in vivo I(h) could be subject to efferent modulation via cyclic nucleotide-dependent mechanisms. In current clamp, hyperpolarizing current steps produced a time-dependent depolarizing sag followed by either a rebound afterdepolarization or an action potential. Spontaneous excitatory postsynaptic potentials (EPSPs) became larger and wider when I(h) was blocked with ZD7288. In a three-dimensional mathematical model of the calyx terminal based on Hodgkin-Huxley type ionic conductances, removal of I(h) similarly increased the EPSP, whereas cAMP slightly decreased simulated EPSP size

  14. The role of current characteristics of the arc evaporator in formation of the surface metal-coating composite

    International Nuclear Information System (INIS)

    Plikhunov, V V; Petrov, L M; Grigorovich, K V

    2016-01-01

    The influence of current characteristics of the vacuum arc evaporator on the interaction process of plasma streams with the surface under treatment during generation of the physicochemical properties of the formed metal-coating composite is considered. It is shown that the interaction of plasma streams with the processed surface provides surface heating, defects elimination, change in energy properties, and mass transfer of plasma stream elements activating surface diffusion processes whose intensity is evaluated by the arc current magnitude and location of the processed surface relative to the cathode axis. (paper)

  15. An Xrootd Italian Federation

    International Nuclear Information System (INIS)

    Boccali, T; Mazzoni, E; Donvito, G; Diacono, D; Marzulli, G; Pompili, A; Ricca, G Della; Argiro, S; Gregori, D; Grandi, C; Bonacorsi, D; Lista, L; Fabozzi, F; Barone, L M; Santocchia, A; Riahi, H; Tricomi, A; Sgaravatto, M; Maron, G

    2014-01-01

    The Italian community in CMS has built a geographically distributed network in which all the data stored in the Italian region are available to all the users for their everyday work. This activity involves at different level all the CMS centers: the Tier1 at CNAF, all the four Tier2s (Bari, Rome, Legnaro and Pisa), and few Tier3s (Trieste, Perugia, Torino, Catania, Napoli, ...). The federation uses the new network connections as provided by GARR, our NREN (National Research and Education Network), which provides a minimum of 10 Gbit/s to all the sites via the GARR-X[2] project. The federation is currently based on Xrootd[1] technology, and on a Redirector aimed to seamlessly connect all the sites, giving the logical view of a single entity. A special configuration has been put in place for the Tier1, CNAF, where ad-hoc Xrootd changes have been implemented in order to protect the tape system from excessive stress, by not allowing WAN connections to access tape only files, on a file-by-file basis. In order to improve the overall performance while reading files, both in terms of bandwidth and latency, a hierarchy of xrootd redirectors has been implemented. The solution implemented provides a dedicated Redirector where all the INFN sites are registered, without considering their status (T1, T2, or T3 sites). An interesting use case were able to cover via the federation are disk-less Tier3s. The caching solution allows to operate a local storage with minimal human intervention: transfers are automatically done on a single file basis, and the cache is maintained operational by automatic removal of old files.

  16. An Xrootd Italian Federation

    Science.gov (United States)

    Boccali, T.; Donvito, G.; Diacono, D.; Marzulli, G.; Pompili, A.; Della Ricca, G.; Mazzoni, E.; Argiro, S.; Gregori, D.; Grandi, C.; Bonacorsi, D.; Lista, L.; Fabozzi, F.; Barone, L. M.; Santocchia, A.; Riahi, H.; Tricomi, A.; Sgaravatto, M.; Maron, G.

    2014-06-01

    The Italian community in CMS has built a geographically distributed network in which all the data stored in the Italian region are available to all the users for their everyday work. This activity involves at different level all the CMS centers: the Tier1 at CNAF, all the four Tier2s (Bari, Rome, Legnaro and Pisa), and few Tier3s (Trieste, Perugia, Torino, Catania, Napoli, ...). The federation uses the new network connections as provided by GARR, our NREN (National Research and Education Network), which provides a minimum of 10 Gbit/s to all the sites via the GARR-X[2] project. The federation is currently based on Xrootd[1] technology, and on a Redirector aimed to seamlessly connect all the sites, giving the logical view of a single entity. A special configuration has been put in place for the Tier1, CNAF, where ad-hoc Xrootd changes have been implemented in order to protect the tape system from excessive stress, by not allowing WAN connections to access tape only files, on a file-by-file basis. In order to improve the overall performance while reading files, both in terms of bandwidth and latency, a hierarchy of xrootd redirectors has been implemented. The solution implemented provides a dedicated Redirector where all the INFN sites are registered, without considering their status (T1, T2, or T3 sites). An interesting use case were able to cover via the federation are disk-less Tier3s. The caching solution allows to operate a local storage with minimal human intervention: transfers are automatically done on a single file basis, and the cache is maintained operational by automatic removal of old files.

  17. Current and Future School Psychologists' Preparedness to Work with LGBT Students: Role of Education and Gay-Straight Alliances

    Science.gov (United States)

    Arora, Prerna G.; Kelly, Jennifer; Goldstein, Thalia R.

    2016-01-01

    This study sought to assess current and future school psychologists' attitudes toward and preparedness to address the needs of lesbian, gay, bisexual, and transgender (LGBT) students in schools. Two-hundred seventy-nine school psychologists (n = 162, 58%) and school psychology graduate students (n = 117, 42%) were included in the study.…

  18. Investigating the role of wind in generating surface currents over the slope area of the Laptev Sea, Arctic Ocean

    Science.gov (United States)

    Patteson, R. N.

    2017-12-01

    Mixing mechanisms of the Arctic Ocean have profound impacts on sea ice, global ocean dynamics, and arctic communities. This project used a two-year long time series of ocean current velocities collected from eight moorings located on the Eurasian basin, as well as ERA-interim wind data, to compare and assess relationships between current and wind velocities at different depths. Determining the strength of these correlations will further scientific understanding of the degree to which wind influences mixing, with implications for heat flux, diffusion, and sea ice changes. Using statistical analysis, I calculated whether a significant relationship between wind velocity and ocean currents existed beginning at the surface level ( 50m) .The final correlation values, ranging from R = 0.11 to R = 0.28, indicated a weak relationship between wind velocity and ocean currents at the surface for all eight mooring sites. The results for the surface depth imply that correlation likely decreases with increasing depths, and thus further testing of deeper depth levels was unnecessary. This finding suggests that there is another dominant factor at play in the ocean; we postulate that topography exerts a significant influence on subsurface mixing. This study highlights the need for further research of the different mechanisms and their importance in influencing the dynamic structure of the ocean.

  19. Using Xrootd to Federate Regional Storage

    International Nuclear Information System (INIS)

    Bauerdick, L; Benjamin, D; Bloom, K; Bockelman, B; Bradley, D; Dasu, S; Ernst, M; Ito, H; Rind, O; Gardner, R; Vukotic, I; Hanushevsky, A; Lesny, D; McGuigan, P; McKee, S; Severini, H; Sfiligoi, I; Tadel, M; Würthwein, F; Williams, S

    2012-01-01

    While the LHC data movement systems have demonstrated the ability to move data at the necessary throughput, we have identified two weaknesses: the latency for physicists to access data and the complexity of the tools involved. To address these, both ATLAS and CMS have begun to federate regional storage systems using Xrootd. Xrootd, referring to a protocol and implementation, allows us to provide data access to all disk-resident data from a single virtual endpoint. This “redirector” discovers the actual location of the data and redirects the client to the appropriate site. The approach is particularly advantageous since typically the redirection requires much less than 500 milliseconds and the Xrootd client is conveniently built into LHC physicists’ analysis tools. Currently, there are three regional storage federations - a US ATLAS region, a European CMS region, and a US CMS region. The US ATLAS and US CMS regions include their respective Tier 1, Tier 2 and some Tier 3 facilities; a large percentage of experimental data is available via the federation. Additionally, US ATLAS has begun studying low-latency regional federations of close-by sites. From the base idea of federating storage behind an endpoint, the implementations and use cases diverge. The CMS software framework is capable of efficiently processing data over high-latency links, so using the remote site directly is comparable to accessing local data. The ATLAS processing model allows a broad spectrum of user applications with varying degrees of performance with regard to latency; a particular focus has been optimizing n-tuple analysis. Both VOs use GSI security. ATLAS has developed a mapping of VOMS roles to specific file system authorizations, while CMS has developed callouts to the site's mapping service. Each federation presents a global namespace to users. For ATLAS, the global-to-local mapping is based on a heuristic-based lookup from the site's local file catalog, while CMS does the mapping

  20. Using Xrootd to federate regional storage

    Energy Technology Data Exchange (ETDEWEB)

    Bauerdick, L.; et al.

    2012-01-01

    While the LHC data movement systems have demonstrated the ability to move data at the necessary throughput, we have identified two weaknesses: the latency for physicists to access data and the complexity of the tools involved. To address these, both ATLAS and CMS have begun to federate regional storage systems using Xrootd. Xrootd, referring to a protocol and implementation, allows us to provide data access to all disk-resident data from a single virtual endpoint. This redirector discovers the actual location of the data and redirects the client to the appropriate site. The approach is particularly advantageous since typically the redirection requires much less than 500 milliseconds and the Xrootd client is conveniently built into LHC physicists analysis tools. Currently, there are three regional storage federations - a US ATLAS region, a European CMS region, and a US CMS region. The US ATLAS and US CMS regions include their respective Tier 1, Tier 2 and some Tier 3 facilities, a large percentage of experimental data is available via the federation. Additionally, US ATLAS has begun studying low-latency regional federations of close-by sites. From the base idea of federating storage behind an endpoint, the implementations and use cases diverge. The CMS software framework is capable of efficiently processing data over high-latency links, so using the remote site directly is comparable to accessing local data. The ATLAS processing model allows a broad spectrum of user applications with varying degrees of performance with regard to latency, a particular focus has been optimizing n-tuple analysis. Both VOs use GSI security. ATLAS has developed a mapping of VOMS roles to specific file system authorizations, while CMS has developed callouts to the site's mapping service. Each federation presents a global namespace to users. For ATLAS, the global-to-local mapping is based on a heuristic-based lookup from the site's local file catalog, while CMS does the mapping

  1. Federalism & bioethics: states and moral pluralism.

    Science.gov (United States)

    Fossett, James W; Ouellette, Alicia R; Philpott, Sean; Magnus, David; McGee, Glenn

    2007-01-01

    Bioethicists are often interested mostly in national standards and institutions, but state governments have historically overseen a wide range of bioethical issues and share responsibility with the federal government for still others. States ought to have an important role. By allowing for multiple outcomes, the American federal system allows a better fit between public opinion and public policies.

  2. Federal Information: Foundation for National Competitiveness.

    Science.gov (United States)

    Clark, Joseph E.; And Others

    1988-01-01

    Seven papers address issues related to the dissemination of federal information to the private sector. General topics addressed include the impact of federal information policy on the flow of scientific and technical information (STI), business needs for STI, and the role of the National Technical Information Service. (13 references) (MES)

  3. Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets.

    Science.gov (United States)

    Sun, Na; Keep, Richard F; Hua, Ya; Xi, Guohua

    2016-10-01

    Sphingolipids are a series of cell membrane-derived lipids which act as signaling molecules and play a critical role in cell death and survival, proliferation, recognition, and migration. Sphingosine-1-phosphate acts as a key signaling molecule and regulates lymphocyte trafficking, glial cell activation, vasoconstriction, endothelial barrier function, and neuronal death pathways which plays a critical role in numerous neurological conditions. Stroke is a second leading cause of death all over the world and effective therapies are still in great demand, including ischemic stroke and hemorrhagic stroke as well as poststroke repair. Significantly, sphingolipid activities change after stroke and correlate with stroke outcome, which has promoted efforts to testify whether the sphingolipid pathway could be a novel therapeutic target in stroke. The sphingolipid metabolic pathway, the connection between the pathway and stroke, as well as therapeutic interventions to manipulate the pathway to reduce stroke-induced brain injury are discussed in this review.

  4. 30 CFR 906.30 - State-Federal cooperative agreement.

    Science.gov (United States)

    2010-07-01

    .... Resolve conflicts and difficulties between other Federal agencies in a timely manner. 3. As soon as.... Publish notices of NEPA documents as required by Federal law and regulations. 5. Take the leadership role...

  5. Inhibition linearizes firing rate responses in human motor units: implications for the role of persistent inward currents.

    Science.gov (United States)

    Revill, Ann L; Fuglevand, Andrew J

    2017-01-01

    Motor neurons are the output neurons of the central nervous system and are responsible for controlling muscle contraction. When initially activated during voluntary contraction, firing rates of motor neurons increase steeply but then level out at modest rates. Activation of an intrinsic source of excitatory current at recruitment onset may underlie the initial steep increase in firing rate in motor neurons. We attempted to disable this intrinsic excitatory current by artificially activating an inhibitory reflex. When motor neuron activity was recorded while the inhibitory reflex was engaged, firing rates no longer increased steeply, suggesting that the intrinsic excitatory current was probably responsible for the initial sharp rise in motor neuron firing rate. During graded isometric contractions, motor unit (MU) firing rates increase steeply upon recruitment but then level off at modest rates even though muscle force continues to increase. The mechanisms underlying such firing behaviour are not known although activation of persistent inward currents (PICs) might be involved. PICs are intrinsic, voltage-dependent currents that activate strongly when motor neurons (MNs) are first recruited. Such activation might cause a sharp escalation in depolarizing current and underlie the steep initial rise in MU firing rate. Because PICs can be disabled with synaptic inhibition, we hypothesized that artificial activation of an inhibitory pathway might curb this initial steep rise in firing rate. To test this, human subjects performed slow triangular ramp contractions of the ankle dorsiflexors in the absence and presence of tonic synaptic inhibition delivered to tibialis anterior (TA) MNs by sural nerve stimulation. Firing rate profiles (expressed as a function of contraction force) of TA MUs recorded during these tasks were compared for control and stimulation conditions. Under control conditions, during the ascending phase of the triangular contractions, 93% of the firing

  6. Interpretation of electrokinetic measurements with porous films: role of electric conductance and streaming current within porous structure.

    Science.gov (United States)

    Yaroshchuk, Andriy; Luxbacher, Thomas

    2010-07-06

    It is shown that in tangential electrokinetic measurements with porous films the porous structure makes contribution not only to the cell electric conductance (as demonstrated previously) but also to the observed streaming current. Both of these contributions give rise to dependences of streaming-potential and streaming-current coefficients on the channel height. However, due to the combined contribution of two phenomena, the dependence of streaming-potential coefficient on the channel height may be rather complicated and not allow for simple extrapolation. At the same time, the dependences of streaming-current coefficient and cell electric conductance on the channel height turn out linear and can be easily extrapolated to zero channel heights. This enables one to determine separately the contributions of external surface of porous film and of its porous structure to the streaming current and of the channel and porous structure to the cell electric conductance. This procedure is illustrated by the measurements of tangential electrokinetic phenomena and electric conductance with Millipore mixed-cellulose membrane filters of various average pore sizes (from 0.025 to 5 mum) in the so-called adjustable-gap cell of SurPASS electrokinetic instrument (Anton Paar GmbH). The design of this cell allows for easy and quasi-continuous variation of channel height as well as accurate determination of cell electric conductance, streaming-current coefficient, and channel height (from the cell hydraulic permeability). The quality of linear fits of experimental data has been found to be very good, and thus, the extrapolation procedures were quite reliable and accurate. Zeta-potentials could be determined of both external film and internal pore surfaces. It is demonstrated that the porous structures make considerable contributions to both streaming-current coefficient and cell electric conductance especially in the case of filters with larger pores. It is also found that, rather

  7. Current intimate relationship status, depression, and alcohol use among bisexual women: The mediating roles of bisexual-specific minority stressors.

    Science.gov (United States)

    Molina, Yamile; Marquez, Jacob H; Logan, Diane E; Leeson, Carissa J; Balsam, Kimberly F; Kaysen, Debra L

    2015-07-01

    Current intimate relationship characteristics, including gender and number of partner(s), may affect one's visibility as a bisexual individual and the minority stressors they experience, which may in turn influence their health. The current study tested four hypotheses: 1) minority stressors vary by current intimate relationship status; 2) higher minority stressors are associated with higher depressive symptoms and alcohol-related outcomes; 3) depressive symptoms and alcohol-related outcomes vary by current intimate relationship status; and 4) minority stressors will mediate differences in these outcomes. Participants included 470 self-identified bisexual women (65% Caucasian, mean age: 21) from a sample of sexual minority women recruited from different geographic regions in the United States through advertisements on social networking sites and Craigslist. Participants completed a 45 minute survey. Respondents with single partners were first grouped by partner gender (male partner: n=282; female partner: n=56). Second, women were grouped by partner gender/number (single female/male partner: n = 338; women with multiple female and male partners: n=132). Women with single male partners and women with multiple male and female partners exhibited elevated experienced bi-negativity and differences in outness (H1). Experienced and internalized bi-negativity were associated with health outcomes, but not outness (H2). Differences in outcomes emerged by partner number and partner number/gender (H3); these differences were mediated by experienced bi-negativity (H4). These results suggest that experiences of discrimination may underlie differences in health related to bisexual women's relationship structure and highlight the importance of evaluating women's relational context as well as sexual identification in understanding health risk behaviors.

  8. Current intimate relationship status, depression, and alcohol use among bisexual women: The mediating roles of bisexual-specific minority stressors

    Science.gov (United States)

    Molina, Yamile; Marquez, Jacob H.; Logan, Diane E.; Leeson, Carissa J.; Balsam, Kimberly F.; Kaysen, Debra L.

    2015-01-01

    Current intimate relationship characteristics, including gender and number of partner(s), may affect one's visibility as a bisexual individual and the minority stressors they experience, which may in turn influence their health. The current study tested four hypotheses: 1) minority stressors vary by current intimate relationship status; 2) higher minority stressors are associated with higher depressive symptoms and alcohol-related outcomes; 3) depressive symptoms and alcohol-related outcomes vary by current intimate relationship status; and 4) minority stressors will mediate differences in these outcomes. Participants included 470 self-identified bisexual women (65% Caucasian, mean age: 21) from a sample of sexual minority women recruited from different geographic regions in the United States through advertisements on social networking sites and Craigslist. Participants completed a 45 minute survey. Respondents with single partners were first grouped by partner gender (male partner: n=282; female partner: n=56). Second, women were grouped by partner gender/number (single female/male partner: n = 338; women with multiple female and male partners: n=132). Women with single male partners and women with multiple male and female partners exhibited elevated experienced bi-negativity and differences in outness (H1). Experienced and internalized bi-negativity were associated with health outcomes, but not outness (H2). Differences in outcomes emerged by partner number and partner number/gender (H3); these differences were mediated by experienced bi-negativity (H4). These results suggest that experiences of discrimination may underlie differences in health related to bisexual women's relationship structure and highlight the importance of evaluating women's relational context as well as sexual identification in understanding health risk behaviors. PMID:26456995

  9. ON THE DETERMINANTS OF UNEMPLOYMENT IN NIGERIA: WHAT ARE THE ROLES OF TRADE OPENNESS AND CURRENT ACCOUNT BALANCE?

    Directory of Open Access Journals (Sweden)

    Isiaka Akande Raifu

    2017-12-01

    Full Text Available Attention of international trade and macroeconomic experts has focused on the effect of international trade, precisely trade openness, on economic growth and by extension on unemployment rate, albeit with mixed results. However, scanty attention has been drawn towards the effect of current account balance on unemployment rate despite the arguments from different quarters trailing such relationship. By employing Autoregressive Distribution Lag estimation technique, this study specifically focuses on the short-run dynamic and long-run effects of trade openness and current account balance on unemployment rate in Nigeria using the data that span 1981-2014. We found that trade openness worsens unemployment rate both in the short-run and long run. We also discovered that in the short run, current account balance increases unemployment rate but reduces it in the long run. Control variables used in the study such as inflation rate, exchange rate, and FDI followed a priori expectation while real GDP, wages and government consumption expenditure failed to follow a priori expectation. We, therefore, concluded that there is need for sound trade and macroeconomic policies to aid domestic firms’ production to ensure international competitiveness of these firms so as to guarantee employment generation.

  10. Federal Standard: Beneficial Use of Dredged Material

    Science.gov (United States)

    The purpose of this document is to provide national guidance that explains the role of the Federal Standard in implementing beneficial uses of dredged material from U.S. Army Corps of Engineers’ new and maintenance navigation projects.

  11. The role of upper mantle mineral phase transitions on the current structure of large-scale Earth's mantle convection.

    Science.gov (United States)

    Thoraval, C.

    2017-12-01

    Describing the large-scale structures of mantle convection and quantifying the mass transfer between upper and lower mantle request to account for the role played by mineral phase transitions in the transition zone. We build a density distribution within the Earth mantle from velocity anomalies described by global seismic tomographic models. The density distribution includes thermal anomalies and topographies of the phase transitions at depths of 410 and 660 km. We compute the flow driven by this density distribution using a 3D spherical circulation model, which account for depth-dependent viscosity. The dynamic topographies at the surface and at the CMB and the geoid are calculated as well. Within the range of viscosity profiles allowing for a satisfying restitution of the long wavelength geoid, we perform a parametric study to decipher the role of the characteristics of phase diagrams - mainly the Clapeyron's slopes - and of the kinetics of phase transitions, which may modify phase transition topographies. Indeed, when a phase transition is delayed, the boundary between two mineral phases is both dragged by the flow and interfere with it. The results are compared to recent estimations of surface dynamic topography and to the phase transition topographies as revealed by seismic studies. The consequences are then discussed in terms of structure of mantle flow. Comparisons between various tomographic models allow us to enlighten the most robust features. At last, the role played by the phase transitions on the lateral variations of mass transfer between upper and lower mantle are quantified by comparison to cases with no phase transitions and confronted to regional tomographic models, which reflect the variability of the behaviors of the descending slabs in the transition zone.

  12. Role of metal/silicon semiconductor contact engineering for enhanced output current in micro-sized microbial fuel cells

    KAUST Repository

    Mink, Justine E.

    2013-11-25

    We show that contact engineering plays an important role to extract the maximum performance from energy harvesters like microbial fuel cells (MFCs). We experimented with Schottky and Ohmic methods of fabricating contact areas on silicon in an MFC contact material study. We utilized the industry standard contact material, aluminum, as well as a metal, whose silicide has recently been recognized for its improved performance in smallest scale integration requirements, cobalt. Our study shows that improvements in contact engineering are not only important for device engineering but also for microsystems. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Exercising the federal radiological emergency response plan

    International Nuclear Information System (INIS)

    Gant, K.S.; Adler, M.V.; Wolff, W.F.

    1986-01-01

    Multiagency exercises were an important part of the development of the Federal Radiological Emergency Response Plan. This paper concentrates on two of these exercises, the Federal Field Exercise in March 1984 and the Relocation Tabletop Exercise in December 1985. The Federal Field Exercise demonstrated the viability and usefulness of the draft plan; lessons learned from the exercise were incorporated into the published plan. The Relocation Tabletop Exercise examined the federal response in the postemergency phase. This exercise highlighted the change over time in the roles of some agencies and suggested response procedures that should be developed or revised. 8 refs

  14. Current advances in polymer electrolyte fuel cells based on the promotional role of under-rib convection

    Energy Technology Data Exchange (ETDEWEB)

    Choi, K.S. [Industrial Technology Cooperation Center, Korea Institute of Energy Research, 152 Gajeong-ro, Yuseong-gu, Daejeon 305-343 (Korea, Republic of); Kim, B.G.; Park, K.; Kim, H.M. [Department of Mechanical Engineering and High Safety Vehicle Core Technology Research Center, INJE University, 607 Eobang-dong, Gimhae, Gyeongnam 621-749 (Korea, Republic of)

    2012-12-15

    Literature data on the promotional role of under-rib convection for polymer electrolyte fuel cells (PEFCs) fueled by hydrogen and methanol are structured and analyzed, thus providing a guide to improving fuel cell performance through the optimization of flow field interaction. Data are presented for both physical and electrochemical performance showing reactant mass transport, electrochemical reaction, water behavior, and power density enhanced by under-rib convection. Performance improvement studies ranging from single cell to stack are presented for measuring the performance of real operating conditions and large-scale setups. The flow field optimization techniques by under-rib convection are derived from the collected data over a wide range of experiments and modeling studies with a variety of components including both single cell and stack arrangements. Numerical models for PEFCs are presented with an emphasis on mass transfer and electrochemical reaction inside the fuel cell. The models are primarily used here as a tool in the parametric analysis of significant design features and to permit the design of the experiment. Enhanced flow field design that utilizes the promotional role of under-rib convection can contribute to commercializing PEFCs. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. Innovation in cardiovascular disease in Europe with focus on arrhythmias: current status, opportunities, roadblocks, and the role of multiple stakeholders.

    Science.gov (United States)

    Prinzen, Frits W; Dagres, Nikolaos; Bollmann, Andreas; Arnar, David O; Bove, Sylvie; Camm, John; Casadei, Barbara; Kirchhof, Paulus; Kuck, Karl-Heinz; Lumens, Joost; Michel, Martin C; Schwartz, Peter J; Van Vleymen, Betty; Vardas, Panos; Hindricks, Gerhard

    2018-05-01

    The European Heart Rhythm Association (EHRA) held an Innovation Forum in February 2016, to consider issues around innovation. The objective of the forum was to extend the innovation debate outside of the narrow world of arrhythmia specialists and cardiology in general, and seek input from all stakeholders including regulators, strategists, technologists, industry, academia, health providers, medical societies, payers, and patients. Innovation is indispensable for a continuing improvement in health care, preferably at higher efficacy and lower costs. It requires people who have been trained in a good scientific environment, high-quality research for achieving ground breaking inventions and the certainty of return on innovation investments. In the context of cardiovascular disease, innovation can imply better risk assessment and stratification, device technology, drug development, and process design. Several areas of promising developments were identified as well as several roadblocks to innovation. To drive innovation forward all stakeholders need to play a significant role. In a globalized and extremely competitive world, the leading role of Europe in medical innovation can only be achieved through a combined and well-coordinated effort from all involved parties.

  16. The role of autobiographical memory networks in the experience of negative emotions: how our remembered past elicits our current feelings.

    Science.gov (United States)

    Philippe, Frederick L; Koestner, Richard; Lecours, Serge; Beaulieu-Pelletier, Genevieve; Bois, Katy

    2011-12-01

    The present research examined the role of autobiographical memory networks on negative emotional experiences. Results from 2 studies found support for an active but also discriminant role of autobiographical memories and their related networked memories on negative emotions. In addition, in line with self-determination theory, thwarting of the psychological needs for competence, autonomy, and relatedness was found to be the critical component of autobiographical memory affecting negative emotional experiences. Study 1 revealed that need thwarting in a specific autobiographical memory network related to the theme of loss was positively associated with depressive negative emotions, but not with other negative emotions. Study 2 showed within a prospective design a differential predictive validity between 2 autobiographical memory networks (an anger-related vs. a guilt-related memory) on situational anger reactivity with respect to unfair treatment. All of these results held after controlling for neuroticism (Studies 1 and 2), self-control (Study 2), and for the valence (Study 1) and emotions (Study 2) found in the measured autobiographical memory network. These findings highlight the ongoing emotional significance of representations of need thwarting in autobiographical memory networks. (c) 2011 APA, all rights reserved.

  17. Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates.

    Science.gov (United States)

    Baumann, Michael H; Bulling, Simon; Benaderet, Tova S; Saha, Kusumika; Ayestas, Mario A; Partilla, John S; Ali, Syed F; Stockner, Thomas; Rothman, Richard B; Sandtner, Walter; Sitte, Harald H

    2014-05-01

    Serotonin (5-HT) transporter (SERT) substrates like fenfluramine and 3,4-methylenedioxymethamphetamine cause long-term depletion of brain 5-HT, while certain other substrates do not. The 5-HT deficits produced by SERT substrates are dependent upon transporter proteins, but the exact mechanisms responsible are unclear. Here, we compared the pharmacology of several SERT substrates: fenfluramine, d-fenfluramine, 1-(m-chlorophenyl)piperazine (mCPP) and 1-(m-trifluoromethylphenyl)piperainze (TFMPP), to establish relationships between acute drug mechanisms and the propensity for long-term 5-HT depletions. In vivo microdialysis was carried out in rat nucleus accumbens to examine acute 5-HT release and long-term depletion in the same subjects. In vitro assays were performed to measure efflux of [(3)H]5-HT in rat brain synaptosomes and transporter-mediated ionic currents in SERT-expressing Xenopus oocytes. When administered repeatedly to rats (6 mg/kg, i.p., four doses), all drugs produce large sustained elevations in extracellular 5-HT (>5-fold) with minimal effects on dopamine. Importantly, 2 weeks after dosing, only rats exposed to fenfluramine and d-fenfluramine display depletion of brain 5-HT. All test drugs evoke fluoxetine-sensitive efflux of [(3)H]5-HT from synaptosomes, but d-fenfluramine and its bioactive metabolite d-norfenfluramine induce significantly greater SERT-mediated currents than phenylpiperazines. Our data confirm that drug-induced 5-HT release probably does not mediate 5-HT depletion. However, the magnitude of transporter-mediated inward current may be a critical factor in the cascade of events leading to 5-HT deficits. This hypothesis warrants further study, especially given the growing popularity of designer drugs that target SERT.

  18. A Survey of University of Medical Sciences’ Administrators and GPs on the Current and Ideal Role of General Practitioners in Iran

    Directory of Open Access Journals (Sweden)

    Bijan Geraili

    2009-07-01

    Full Text Available Background and purpose: roles and tasks of intended graduates direct medical eductionist for developing the right curriculum. In Iran there has been no systematic study on defining GPs roles. This study is an attempt to systematically clarify the roles of GPs in Iran.Methods: In this questionnaire – based survey executive directors of Universities of medicine of Iran and general practitioners participated. The subjects were selected through stratified sampling procedure. A semi-structured questionnaire was developed which covered the goals and functions of health system as mentioned in World Health Report 2000. For content validity a panel of experts including health care professionals, biostatisticians, and psychometrist evaluated the questionnaire. For the reliability of the questionnaire a pilot study was carried out. Chronbach’s coeficient were calculated as 0.89 .The final revision of the questionnaire included 15 roles in current and ideal states. The respondent should score each role in both states in a range of 0-100.Results: Of 94 subjects who received the questionnaire, 71 (80% completed and returned it. Of all subjects 42.2% were female and 57.8% were male. Of all subjects 25% were faculty members. The subjects believe that in the current state “health care provision” (85.4±18.6 “health center administration” (57.8±24.8, and “leading clinical services and coordinating patients care” (47.6±26.8 are more evident while “fund holding” had the lowest rank(5.0±10.0. They believed that in an ideal national health system physicians should play most of these roles in various extents.Conclusion: The participants believed that GPs should play other roles beyond the clinical care provision to enable health system respond to community needs and expectations. The graduate medical degree should be reformed if the gradates are going to play these new roles.Key words: Role Definition, Curr iculum Development, GP, Primary Health

  19. Management of end stage liver disease (ESLD): what is the current role of orthotopic liver transplantation (OLT)?

    Science.gov (United States)

    Miró, José M; Laguno, Montserrat; Moreno, Asuncion; Rimola, Antonio

    2006-01-01

    Liver disease due to chronic hepatitis B and C is now a leading cause of morbidity and mortality among HIV-infected patients in the developed world, where classical opportunistic complications of severe immunodeficiency have declined dramatically. Orthotopic liver transplantation (OLT) is the only therapeutic option for patients with end-stage liver disease (ESLD). Accumulated experience in North America and Europe in the last 5 years indicates that 3-year survival in selected HIV-infected recipients of liver transplants was similar to that of HIV-negative recipients. So, HIV infection by itself is not therefore a contraindication for liver transplantation. As survival of HIV-infected patients with ESLD is shorter than non-HIV-infected population, the evaluation for OLT should be made after the first liver decompensation. The current selection criteria for HIV-positive transplant candidates include: no history of opportunistic infections or HIV-related neoplasms, CD4 cell count > 100 cells/mm(3), and plasma HIV viral load suppressible with antiretroviral treatment. For drug abusers, a 2-year abstinence from heroin and cocaine is required, although patients can be in a methadone programme. The main problems in the post-transplant period are pharmacokinetic and pharmacodynamic interactions between antiretrovirals and immunosuppressive drugs, and the management of relapse of HCV infection. Up to now, experience with pegylated interferon and ribavirin is scarce in this population. Currently, HCV re-infection is the main cause for concern.

  20. Underlying role of mitochondrial mutagenesis in the pathogenesis of a disease and current approaches for translational research.

    Science.gov (United States)

    Paraskevaidi, Maria; Martin-Hirsch, Pierre L; Kyrgiou, Maria; Martin, Francis L

    2017-05-01

    Mitochondrial diseases have been extensively investigated over the last three decades, but many questions regarding their underlying aetiologies remain unanswered. Mitochondrial dysfunction is not only responsible for a range of neurological and myopathy diseases but also considered pivotal in a broader spectrum of common diseases such as epilepsy, autism and bipolar disorder. These disorders are a challenge to diagnose and treat, as their aetiology might be multifactorial. In this review, the focus is placed on potential mechanisms capable of introducing defects in mitochondria resulting in disease. Special attention is given to the influence of xenobiotics on mitochondria; environmental factors inducing mutations or epigenetic changes in the mitochondrial genome can alter its expression and impair the whole cell's functionality. Specifically, we suggest that environmental agents can cause damage in mitochondrial DNA and consequently lead to mutagenesis. Moreover, we describe current approaches for handling mitochondrial diseases, as well as available prenatal diagnostic tests, towards eliminating these maternally inherited diseases. Undoubtedly, more research is required, as current therapeutic approaches mostly employ palliative therapies rather than targeting primary mechanisms or prophylactic approaches. Much effort is needed into further unravelling the relationship between xenobiotics and mitochondria, as the extent of influence in mitochondrial pathogenesis is increasingly recognised. © The Author 2016. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. Biogeographical role of the Kuroshio Current in the amphibious mudskipper Periophthalmus modestus indicated by mitochondrial DNA data

    Science.gov (United States)

    He, Lijun; Mukai, Takahiko; Hou Chu, Ka; Ma, Qiang; Zhang, Jing

    2015-10-01

    Quaternary climatic cycles have influenced marine organisms’ spatial distribution and population dynamics. This study aimed to elucidate the evolutionary influences of contemporary and glacial physical barriers on the population structure, demography and colonization history of the mudskipper (Periophthalmus modestus) based on a mitochondrial gene segment (ND5) from 131 individual fish sampled in the northwestern Pacific Ocean. The current Kuroshio Current and the glacial exposure of the Taiwan Strait appeared to have restricted migration among the South China Sea, coastal East China and Japan. However, genetic homogeneity (Nm>1) also suggested contemporary larval transportation by sea circulation between the East China Sea and the South China Sea or historical dispersal along the glacial exposed shoreline among China, Japan and the Ryukyu Islands. Evolutionary signals of the strengthened East Asian Summer Monsoon in the mid-Pleistocene and regional difference in intertidal primary productions were indicated by a late-Pleistocene population expansion of P. modestus with a higher effective population size in the South China Sea than in the East China Sea. Furthermore, a potential colonization origin from the South China Sea was consistently inferred by different clues, including the populations’ coalescence times, the ancestral haplotype distribution, the number of private haplotypes and species/genetic diversity.

  2. Preparing nursing students for enhanced roles in primary care: The current state of prelicensure and RN-to-BSN education.

    Science.gov (United States)

    Wojnar, Danuta M; Whelan, Ellen Marie

    With the current emphasis on including registered nurses (RNs) on the primary care teams, it is essential that nursing programs prepare students for employment in these settings. This study explored the current state of prelicensure and RN-to-Bachelor of Science in Nursing (BSN) online education regarding the implementation of primary care content in the curricula. A sample of 1,409 schools and/or colleges from across the United States was invited to participate in an online survey. About 529 surveys were returned for an overall response rate of 37.5%. Summative content analysis was used to analyze survey data. Although most respondents have implemented some primary care content, some found it challenging and others have demurred from incorporating primary care content altogether. Nursing leaders and faculty in academia must collaborate with clinical partners to design and expand didactic and clinical learning experiences that emphasize primary care content in the prelicensure and RN-to-BSN education. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. The Role of Cold Work in Eddy Current Residual Stress Measurements in Shot-Peened Nickel-Base Superalloys

    International Nuclear Information System (INIS)

    Yu, F.; Nagy, P. B.

    2006-01-01

    Recently, it was shown that eddy current methods can be adapted to residual stress measurement in shot-peened nickel-base superalloys. However, experimental evidence indicates that the piezoresistivity effect is simply not high enough to account for the observed apparent eddy current conductivity (AECC) increase. At the same time, X-ray diffraction data indicates that 'cold work' lingers even when the residual stress is fully relaxed and the excess AECC is completely gone. It is impossible to account for both observations with a single coherent explanation unless we assume that instead of a single 'cold work' effect, there are two varieties of cold work; type-A and type-B. Type-A cold work (e.g., changes in the microscopic homogeneity of the material) is not detected by X-ray diffraction as it does not significantly affect the beam width, but causes substantial conductivity change and exhibits strong thermal relaxation. Type-B cold work (e.g., dislocations) is detected by X-ray, but causes little or no conductivity change and exhibits weak thermal relaxation. Based on the assumption of two separate cold-work variables and that X-ray diffraction results indicate the presence of type-B, but not type-A, all observed phenomena can be explained. If this working hypothesis is proven right, the separation of residual stress and type-A cold work is less critical because they both relax much earlier and much faster than type-B cold work

  4. Gestational surrogacy and the role of routine embryo screening: Current challenges and future directions for preimplantation genetic testing.

    Science.gov (United States)

    Sills, E Scott; Anderson, Robert E; McCaffrey, Mary; Li, Xiang; Arrach, Nabil; Wood, Samuel H

    2016-03-01

    Preimplantation genetic screening (PGS) is a component of IVF entailing selection of an embryo for transfer on the basis of chromosomal normalcy. If PGS were integrated with single embryo transfer (SET) in a surrogacy setting, this approach could improve pregnancy rates, minimize miscarriage risk, and limit multiple gestations. Even without PGS, pregnancy rates for IVF surrogacy cases are generally satisfactory, especially when treatment utilizes embryos derived from young oocytes and transferred to a healthy surrogate. However, there could be a more general role for PGS in surrogacy, since background aneuploidy in embryos remains a major factor driving implantation failure and miscarriage for all infertility patients. At present, the proportion of IVF cases involving GS is limited, while the number of IVF patients requesting PGS appears to be increasing. In this report, the relevance of PGS for surrogacy in the rapidly changing field of assisted fertility medicine is discussed. © 2015 Wiley Periodicals, Inc.

  5. Federal Fleet Report

    Data.gov (United States)

    General Services Administration — Annual report of Federal agencies' motor vehicle fleet data collected in the Federal Automotive Statistical Tool (FAST), a web-based reporting tool cosponsored by...

  6. Federal Register in XML

    Data.gov (United States)

    National Archives and Records Administration — The Federal Register is the official daily publication for rules, proposed rules, and notices of Federal agencies and organizations, as well as executive orders and...

  7. Nuclear waste management: a challenge to Federalism

    International Nuclear Information System (INIS)

    Lucas, P.

    1979-01-01

    The controversy over state/Federal authority over waste disposal has already had a significant effect regardless of the choice Congress ultimately makes between an informal deference to state will and a statutory authorization of state control over Federal repositories. The highly emotional issue of local disposal of nuclear waste and the assertions of state control over waste disposal have made the nation and the Federal bureaucracy more aware of the status of the waste management program. State resistance to Federal siting efforts and the passage of state waste disposal legislation has compelled the Federal government to provide the states with a larger role in waste management. State power to exclude Federal repositories would give states additional political leverage. Ideally, public attention and effective state veto power will contribute to a more successful program, without impeding progress toward the immediate goal of siting and developing permanent repositories

  8. 2010 Northwest Federal Market Assessment Report

    Energy Technology Data Exchange (ETDEWEB)

    Scanlon, Tim; Sandusky, William F.

    2011-09-01

    The primary intent of this market assessment is to provide insights on the effectiveness of current energy efficiency and renewable energy program offerings available to Federal sites in the region. The level of detail, quality and currency of the data used in this market assessment varies significantly by Federal agency and energy efficiency service provider. Limited access to some Federal sites, limited availability of key points of contact, time/resource constraints, and other considerations limited the total number of Federal agencies and energy efficiency service providers participating in the survey.

  9. Energy report of the Federal German Government

    International Nuclear Information System (INIS)

    1986-01-01

    In its governmental declaration of May 4th, 1983, the Federal German Government has pointed out how it will safeguard the continuous, economical, and non-polluting supply of energy to the Federal Republic of Germany. By that report the Federal Government strikes a balance of its policy and defines its position with regard to topical questions, especially the peaceful use of nuclear energy. The report comprises four chapters: 1. peaceful use of nuclear energy in the Federal Republic of Germany, 2. Summary statement on energy policy, 3. Current situation in the energy market and long-term perspectives, 4. Points of main emphasis of future energy policy. (orig./UA) [de

  10. The role of interfacial defects in enhancing the critical current density of YBa2Cu3O7-delta coatings

    Energy Technology Data Exchange (ETDEWEB)

    Foltyn, Stephen R [Los Alamos National Laboratory; Wang, Haiyan [Los Alamos National Laboratory; Civale, Leonardo [Los Alamos National Laboratory; Maiorov, Boris A [Los Alamos National Laboratory; Jia, Quanxi [Los Alamos National Laboratory

    2009-01-01

    The critical current density (J{sub c}) of YBa{sub 2}Cu{sub 3}0{sub 7-{delta}} (YBCO) films can approach 10 MA/cm{sup 2} at 77 K in self field , but only for very thin films. We have shown previously that strong thickness dependence results if J{sub c} is enhanced near the film-substrate interface. In the present work we investigate interfacial enhancement using laser-deposited YBCO films on NdGaO{sub 3} substrates, and find that we can adjust deposition conditions to switch the enhancement on and off. Interestingly, we find that the 'on' state is accompanied by interfacial misfit dislocations, establishing an unambiguous correlation between enhanced J{sub c} and dislocations at the film-substrate interface.

  11. The role of feedback resistors and tid effects in the ASET response of a high speed current feedback amplifier

    International Nuclear Information System (INIS)

    Roig, F.; Dusseau, L.; Privat, A.; Vaille, J.R.; Boch, J.; Saigne, F.; Ribeiro, P.; Auriel, G.; Roche, N.J.H.; Marec, R.; Calvel, P.; Bezerra, F.; Ecoffet, R.; Azais, B.

    2014-01-01

    The influence of external circuit designs on ASET shapes in a high speed current feedback amplifier (CFA) (AD844) is investigated by means of the pulsed laser single event effect (PLSEE) simulation technique. Changes of the feedback resistors modify circuit's electrical parameters such as closed-loop gain and bandwidth, affecting amplifier stability and so ASET shapes. Qualitative explanations based on general electronic rules and feedback theories enable the understanding of a CFA operation establishing a correlation between the evolution of external feedback resistor values and ASET parameters. TID effects on the ASET sensitivity in AD844 CFA are also investigated in this work highlighting different behaviors according to the impacted bipolar transistor in the integrated circuit. (authors)

  12. Nuclear supervision - Administration by the federal states on behalf of the Federal Government or direct federal administration for optimum achievement

    International Nuclear Information System (INIS)

    Renneberg, W.

    2005-01-01

    One year ago, Federal Minister for the Environment Juergen Trittin expressed doubt about the long-term viability of the federal states' acting on behalf of the federal government in the field of atomic energy law administration. An alternative to this type of administration was mentioned, namely direct execution by the feral government, and a thorough examination was announced. This was to show which type of administration would achieve maximum safety for the residual operating lives of nuclear power plants. Kienbaum Management Consultants were commissioned to evaluate the current status and potential alternative structures. That study was performed within the framework of one of the key projects in reactor safety of the Federal Ministry for the Environment, Nature Conservation, and Nuclear Safety (BMU), namely the reform of nuclear administration. Further steps to be taken by the BMU by the end of this parliamentary term are presented. The federal state are to be approached in an attempt to conduct an unbiased discussion of the pros and cons of the alternatives to administration by the federal states on behalf of the federal government. Questions will be clarified which need to be examined in depth before direct administration by the federal government can be introduced. These include constitutional matters and matters of costing in financing the higher-level federal authority as well as specific questions about the organization of that authority. The purpose is to elaborate, by the end of this parliamentary term, a workable concept of introducing direct federal administration of nuclear safety. (orig.)

  13. ACHP | Unified Federal Review

    Science.gov (United States)

    Search skip specific nav links Home arrow Unified Federal Review Three logos: 1) Executive Office of the Homeland Security. Unified Federal Environmental and Historic Preservation Review Process Please visit the new location for the Unified Federal Review located here: http://www.fema.gov/environmental-historic

  14. Framing Canadian federalism

    National Research Council Canada - National Science Library

    Saywell, John; Anastakis, Dimitry; Bryden, Penny E

    2009-01-01

    ... the pervasive effects that federalism has on Canadian politics, economics, culture, and history, and provide a detailed framework in which to understand contemporary federalism. Written in honour of John T. Saywell's half-century of accomplished and influential scholarly work and teaching, Framing Canadian Federalism is a timely and fitting t...

  15. 13 CFR 314.5 - Federal Share.

    Science.gov (United States)

    2010-01-01

    ... marketing costs. (b) The Federal Share excludes that portion of the current fair market value of the..., which are not included in the total Project costs. For example, if the total Project costs are $100...

  16. The Domino Effects of Federal Research Funding.

    Science.gov (United States)

    Lanahan, Lauren; Graddy-Reed, Alexandra; Feldman, Maryann P

    2016-01-01

    The extent to which federal investment in research crowds out or decreases incentives for investment from other funding sources remains an open question. Scholarship on research funding has focused on the relationship between federal and industry or, more comprehensively, non-federal funding without disentangling the other sources of research support that include nonprofit organizations and state and local governments. This paper extends our understanding of academic research support by considering the relationships between federal and non-federal funding sources provided by the National Science Foundation Higher Education Research and Development Survey. We examine whether federal research investment serves as a complement or substitute for state and local government, nonprofit, and industry research investment using the population of research-active academic science fields at U.S. doctoral granting institutions. We use a system of two equations that instruments with prior levels of both federal and non-federal funding sources and accounts for time-invariant academic institution-field effects through first differencing. We estimate that a 1% increase in federal research funding is associated with a 0.411% increase in nonprofit research funding, a 0.217% increase in state and local research funding, and a 0.468% increase in industry research funding, respectively. Results indicate that federal funding plays a fundamental role in inducing complementary investments from other funding sources, with impacts varying across academic division, research capacity, and institutional control.

  17. Federal Technology Alert: Ground-Source Heat Pumps Applied to Federal Facilities-Second Edition; FINAL

    International Nuclear Information System (INIS)

    Hadley, Donald L

    2001-01-01

    This Federal Technology Alert, which was sponsored by the U.S. Department of Energy's Office of Federal Energy Management Programs, provides the detailed information and procedures that a Federal energy manager needs to evaluate most ground-source heat pump applications. This report updates an earlier report on ground-source heat pumps that was published in September 1995. In the current report, general benefits of this technology to the Federal sector are described, as are ground-source heat pump operation, system types, design variations, energy savings, and other benefits. In addition, information on current manufacturers, technology users, and references for further reading are provided

  18. The role of stress and beta-adrenergic system in melanoma: current knowledge and possible therapeutic options.

    Science.gov (United States)

    Colucci, Roberta; Moretti, Silvia

    2016-05-01

    The aim of the present review was to discuss recent findings on the role of beta-adrenergic system in melanoma, in order to provide information on the biological responses elicited by its activation and its potential application for melanoma treatment. A literature search was performed, and evidences regarding the involvement of stress and beta-adrenergic system in cancer and melanoma were found and discussed. Our search pointed out that beta-adrenergic system is a key regulator of important biological processes involved in the onset and progression of some solid tumors. In the last decade, functional beta-adrenoceptors have been also identified on melanoma cells, as well as on their microenvironment cells. Similarly to other common cancers too, the activation of such adrenoceptors by catecholamines, usually released under stress conditions, has been found to trigger pro-tumorigenic pathways contributing to cell proliferation and motility, immune system regulation, apoptosis, epithelial-mesenchymal transition, invasion and neoangiogenesis. The biological evidences we found clarify and sustain the clinical evidences reporting the involvement of chronic stress in melanoma onset and progression. In such scenario, it is conceivable that a therapeutic approach targeting beta-adrenergic system could constitute a novel and promising strategy for melanoma treatment.

  19. The role of hospital payments in the adoption of new medical technologies: an international survey of current practice.

    Science.gov (United States)

    Sorenson, Corinna; Drummond, Michael; Torbica, Aleksandra; Callea, Giuditta; Mateus, Ceu

    2015-04-01

    This study examined the role of prospective payment systems in the adoption of new medical technologies across different countries. A literature review was conducted to provide background for the study and guide development of a survey instrument. The survey was disseminated to hospital payment systems experts in 15 jurisdictions. Fifty-one surveys were disseminated, with 34 returned. The surveys returned covered 14 of the 15 jurisdictions invited to participate. The majority (71%) of countries update the patient classification system and/or payment tariffs on an annual basis to try to account for new technologies. Use of short-term separate or supplementary payments for new technologies occurs in 79% of countries to ensure adequate funding and facilitate adoption. A minority (43%) of countries use evidence of therapeutic benefit and/or costs to determine or update payment tariffs, although it is somewhat more common in establishing short-term payments. The main barrier to using evidence is uncertain or unavailable clinical evidence. Almost three-fourths of respondents believed diagnosis-related group systems incentivize or deter technology adoption, depending on the particular circumstances. Improvements are needed, such as enhanced strategies for evidence generation and linking evidence of value to payments, national and international collaboration and training to improve existing practice, and flexible timelines for short-term payments. Importantly, additional research is needed to understand how different payment policies impact technology uptake as well as quality of care and costs.

  20. What's happening? The expanding role of apheresis platelet support in neonatal alloimmune thrombocytopenia: current status and future trends.

    Science.gov (United States)

    Bessos, Hagop; Seghatchian, Jerard

    2005-10-01

    Despite some unresolved problems that may be associated with platelet transfusion, such as alloimmunisation, refractoriness, bacterial contamination, and the potential side effects related to the development of some biological response modifiers during storage, platelet therapy remains the most effective treatment for the management and prevention of severe thrombocytopenia and hemorrhage [Seghatchian J, Snyder EL, Krailadsiri P, editors. Platelet therapy: current status and future trends. Amsterdam, The Netherlands: Elsevier; 2000]. This appears to be particularly the case in neonatal alloimmune thrombocytopenia (NAIT), which arises due to an incompatibility of the platelet specific antigens between the pregnant mother and her baby. Over 80% of severe NAIT cases in the Caucasian population occur when the mother and baby differ in their HPA-1 epitope (HPA-1a negative and positive respectively) leading, in 10% of cases, to the production of anti-HPA-1a which can cross the placenta and cause NAIT in utero or post-partum. Anti-HPA-5b is the second most cause of NAIT, although severe cases occur only after the first pregnancy. Clinical manifestations of NAIT vary from mild (petechia and bruises) to severe (intracranial haemorrhage with possible death or life long morbidity). A recent study in Scotland indicated that the cost per case of severe NAIT detected during screening of pregnant women, where anti-HPA-1a is detected for the first time, would amount to $98,771 [Turner M, Bessos H, et al. Prospective epidemiological study of the outcome and cost effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia (NAIT) due to anti-HPA-1a. Transfusion, in press. Yet, unlike the case with Rhesus hemolytic disease of the new born, the cost-effectiveness of HPA-1 screening in NAIT remains unresolved, as does the most optimal mode of treatment. Therefore, in the absence of a consensus on the screening and optimal management of NAIT, the availability and

  1. The politics of federal environmental education policy

    Science.gov (United States)

    Crouch, Richard Craig

    Both environmental governance1 and education governance 2 occupy contested territory in contemporary US political discourse. Environmental education (EE) policy has emerged at this intersection and taken on aspects of both controversies. Central to debates surrounding environmental education are still unresolved issues concerning the role of the federal government in education, the role of education in citizen-making, and the role of the public in environmental governance. As a case study of the politics of environmental education policy, I explore these issues as they relate to the National Environmental Education Act of 1990,3 attempts at its reauthorization, its continued appropriations, and its current state of policy stasis. The political controversy over the federal role in environmental education is an appropriate case study of environmental education politics insofar as it reflects the different positions held by actor groups with regard to the definition, efficacy, and legitimacy of environmental education. At the core of these debates, as we will see, is a definitional crisis---that is, there is no common understanding across the relevant actor groups as to what environmental education is, or should be. I suggest here that this definitional issue can be best understood as having technical, ideological, and structural components4---all of which are mutually reinforcing and thus perpetuate the stasis in federal environmental education policy. 1I rely on Durant, Fiorino and O'leary's definition of environmental governance in Environmental Governance Reconsidered ; "In the term environmental governance, we refer to the increasingly collaborative nature of [environmental and natural resource] policy formulation and implementation. In this vein, a wide array of third parties (for example, actors in the profit sector, the nonprofit sector, and civic society), in addition to government agencies, comprise non hierarchical networks of actors wielding a variety of

  2. The role of gene-environment interplay in occupational and environmental diseases: current concepts and knowledge gaps.

    Science.gov (United States)

    Kwo, Elizabeth; Christiani, David

    2017-03-01

    The interplay between genetic susceptibilities and environmental exposures in the pathogenesis of a variety of diseases is an area of increased scientific, epidemiologic, and social interest. Given the variation in methodologies used in the field, this review aims to create a framework to help understand occupational exposures as they currently exist and provide a foundation for future inquiries into the biological mechanisms of the gene-environment interactions. Understanding of this complex interplay will be important in the context of occupational health, given the public health concerns surrounding a variety of occupational exposures. Studies found evidence that suggest genetics influence the progression of disease postberyllium exposure through genetically encoded major histocompatibility complex, class II, DP alpha 2 (HLA-DP2)-peptide complexes as it relates to T-helper cells. This was characterized at the molecular level by the accumulation of Be-responsive CD4 T cells in the lung, which resulted in posttranslational change in the HLA-DPB1 complex. These studies provide important evidence of gene-environment association, and many provide insights into specific pathogenic mechanisms. The following includes a review of the literature regarding gene-environment associations with a focus on pulmonary diseases as they relate to the workplace.

  3. Computing and the Crisis: The Significant Role of New Information Technologies in the Current Socio-economic Meltdown

    Directory of Open Access Journals (Sweden)

    David Hakken

    2010-08-01

    Full Text Available There is good reason to be concerned about the long-term implications of the current crisis for the reproduction of contemporary social formations. Thus there is an urgent need to understand it character, especially its distinctive features. This article identifies profound ambiguities in valuing assets as new and key economic features of this crisis, ambiguities traceable to the dominant, “computationalist” computing used to develop new financial instruments. After some preliminaries, the article identifies four specific ways in which computerization of finance is generative of crisis. It then demonstrates how computationalist computing is linked to other efforts to extend commodification based on the ideology of so-called “intellectual property” (IP. Several other accounts for the crisis are considered and then demonstrated to have less explanatory value. After considering how some commons-oriented (e.g., Free/Libre and/or Opening Source Software development projects forms of computing also undermine the IP project, the article concludes with a brief discussion of what research on Socially Robust and Enduring Computing might contribute to fostering alternative, non-crisis generative ways to compute.

  4. Role of VEGF, Nitric Oxide and sympathetic neurotransmitters in the pathogenesis of tendinopathy: a review of the current evidences

    Directory of Open Access Journals (Sweden)

    Sebastiano Vasta

    2016-08-01

    Full Text Available Chronic tendinopathy is a painful common condition affecting athletes as well as the general population undergoing to tendon overuse. Although its huge prevalence, little is known about tendinopathy pathogenesis, and even cloudier is its treatment.Traditionally, tendinopathy has been defined as a lack of tendon ability to overcome stressing stimuli with appropriate adaptive changes. Histologic studies have demonstrated the absence of inflammatory infiltrates, as a consequence conventional antinflammatory drugs have shown little or no effectiveness in treating tendinopathies. New strategies should be therefore identified to address chronic tendon disorders. Angiofibroblastic changes have been highlighted as the main feature of tendinopathy, and vascular endothelial growth factor (VEGF has been demonstrated as one of the key molecules involved in vascular hyperplasia. More recently, attention has been focused on new peptides such as Substance P, nitric oxide and calcitonin gene-related peptide. Those new findings support the idea of a nerve-mediated disregulation of tendon metabolism. Each of those molecules could be a target for new treatment options. This study aimed to systematically review the current available clinical and basic science in order to summarize the latest evidences on the pathophysiology and its effect on treatment of chronic tendinopathy, and to spread suggestions for future research on its treatment.

  5. A comprehensive analysis of the current and future role of biofuels for transport in the European Union (EU

    Directory of Open Access Journals (Sweden)

    Massimo Raboni1

    2015-01-01

    Full Text Available The production of biofuels is strongly supported all over the world as a renewable energy source for reducing dependence on the unstable oil market. Bioethanol, the main biofuel produced in the world, is widely used to power vehicles in both the USA and Brazil, but concerns exist in both places regarding its sustainability. In Brazil, it is produced from a by-product of the sugar cane industry, while in the USA it is manufactured from food crops. The production of biogas and biodiesel is growing rapidly, but neither has outpaced the production of bioethanol. The European Union (EU is greatly interested in this issue, and in 2011 adopted an extensive strategy to reduce carbon dioxide emissions related to transport by 60% by the year 2050. In order to achieve this result, the current European transportation system must be transformed. This ambitious goal will require the implementation of complex measures including the reduction of fossil fuels in favor of renewable fuels. This program has various options regarding the development of biofuels (e. g., biogas, bioethanol and biodiesel and their related technologies, which are still on trial (mainly regarding the bioethanol production, and must also analyze their sustainability from a social and economic standpoint. The paper discusses the use of biofuels for transport in the European setting, and shows that their sustainability may result in relevant negative social effects due mainly to the use of land for energy crops (e.g., change of food price and world food shortage.

  6. An important role of the moisture supply from the Kuroshio Current/Kuroshio Extension in the rapid development of an explosive cyclone

    Science.gov (United States)

    Hirata, H.; Kawamura, R.; Kato, M.; Shinoda, T.

    2014-12-01

    We investigated how the moisture supply from the Kuroshio Current/Kuroshio Extension affects the rapid intensification of an explosive cyclone using a couple atmosphere-ocean non-hydrostatic model, CReSS-NHOES. The Cloud-Resolving Storm Simulator (CReSS) and the Non-Hydrostatic Ocean model for the Earth Simulator (NHOES) have been developed by the Hydrospheric Atmospheric Research Center of Nagoya University and the Japan Agency for Marine-Earth Science and Technology, respectively. We performed a numerical simulation of an extratropical cyclone migrating along the southern periphery of the Kuroshio Current on January 14, 2013, that developed most rapidly in recent years in the vicinity of Japan. The evolutions of surface fronts related to the cyclone simulated by the CReSS-NHOES closely resemble Shapiro-Keyser model. In the lower troposphere, the cyclone's bent-back front and the associated frontal T-bone structure become evident with the cyclone development. Cold Conveyor Belt (CCB) is also well organized over the northern part of the cyclone. During its developing stage, since the CCB dominates just over the Kuroshio Current/Kuroshio Extension, a large amount of moisture is efficiently supplied from the warm current into the CCB. The vapor evaporated from the underlying warm current is transported into the bent-back front by the CCB and converges horizontally in the vicinity of the front. As a result, strong diabatic heating arises over the corresponding moisture convergence area in that vicinity, indicating that the abundant moisture due to the warm current plays a vital role in rapid development of the cyclone through latent heat release processes. Both processes of the moisture transport from the warm current into the cyclone system via the CCB and of the latent heat release around the bent-back front are also confirmed by trajectory analyses. The rapid SLP decrease of the cyclone center can in turn increase the moisture supply from the warm current through

  7. Role of action potential configuration and the contribution of C²⁺a and K⁺ currents to isoprenaline-induced changes in canine ventricular cells.

    Science.gov (United States)

    Szentandrássy, N; Farkas, V; Bárándi, L; Hegyi, B; Ruzsnavszky, F; Horváth, B; Bányász, T; Magyar, J; Márton, I; Nánási, P P

    2012-10-01

    Although isoprenaline (ISO) is known to activate several ion currents in mammalian myocardium, little is known about the role of action potential morphology in the ISO-induced changes in ion currents. Therefore, the effects of ISO on action potential configuration, L-type Ca²⁺ current (I(Ca)), slow delayed rectifier K⁺ current (I(Ks)) and fast delayed rectifier K⁺ current (I(Kr)) were studied and compared in a frequency-dependent manner using canine isolated ventricular myocytes from various transmural locations. Action potentials were recorded with conventional sharp microelectrodes; ion currents were measured using conventional and action potential voltage clamp techniques. In myocytes displaying a spike-and-dome action potential configuration (epicardial and midmyocardial cells), ISO caused reversible shortening of action potentials accompanied by elevation of the plateau. ISO-induced action potential shortening was absent in endocardial cells and in myocytes pretreated with 4-aminopyridine. Application of the I(Kr) blocker E-4031 failed to modify the ISO effect, while action potentials were lengthened by ISO in the presence of the I(Ks) blocker HMR-1556. Both action potential shortening and elevation of the plateau were prevented by pretreatment with the I(Ca) blocker nisoldipine. Action potential voltage clamp experiments revealed a prominent slowly inactivating I(Ca) followed by a rise in I(Ks) , both currents increased with increasing the cycle length. The effect of ISO in canine ventricular cells depends critically on action potential configuration, and the ISO-induced activation of I(Ks) - but not I(Kr) - may be responsible for the observed shortening of action potentials. © 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.

  8. Role of action potential configuration and the contribution of Ca2+ and K+ currents to isoprenaline-induced changes in canine ventricular cells

    Science.gov (United States)

    Szentandrássy, N; Farkas, V; Bárándi, L; Hegyi, B; Ruzsnavszky, F; Horváth, B; Bányász, T; Magyar, J; Márton, I; Nánási, PP

    2012-01-01

    BACKGROUND AND PURPOSE Although isoprenaline (ISO) is known to activate several ion currents in mammalian myocardium, little is known about the role of action potential morphology in the ISO-induced changes in ion currents. Therefore, the effects of ISO on action potential configuration, L-type Ca2+ current (ICa), slow delayed rectifier K+ current (IKs) and fast delayed rectifier K+ current (IKr) were studied and compared in a frequency-dependent manner using canine isolated ventricular myocytes from various transmural locations. EXPERIMENTAL APPROACH Action potentials were recorded with conventional sharp microelectrodes; ion currents were measured using conventional and action potential voltage clamp techniques. KEY RESULTS In myocytes displaying a spike-and-dome action potential configuration (epicardial and midmyocardial cells), ISO caused reversible shortening of action potentials accompanied by elevation of the plateau. ISO-induced action potential shortening was absent in endocardial cells and in myocytes pretreated with 4-aminopyridine. Application of the IKr blocker E-4031 failed to modify the ISO effect, while action potentials were lengthened by ISO in the presence of the IKs blocker HMR-1556. Both action potential shortening and elevation of the plateau were prevented by pretreatment with the ICa blocker nisoldipine. Action potential voltage clamp experiments revealed a prominent slowly inactivating ICa followed by a rise in IKs, both currents increased with increasing the cycle length. CONCLUSIONS AND IMPLICATIONS The effect of ISO in canine ventricular cells depends critically on action potential configuration, and the ISO-induced activation of IKs– but not IKr– may be responsible for the observed shortening of action potentials. PMID:22563726

  9. Recalled and current gender role behavior, gender identity and sexual orientation in adults with Disorders/Differences of Sex Development.

    Science.gov (United States)

    Callens, Nina; Van Kuyk, Maaike; van Kuppenveld, Jet H; Drop, Stenvert L S; Cohen-Kettenis, Peggy T; Dessens, Arianne B

    2016-11-01

    The magnitude of sex differences in human brain and behavior and the respective contributions of biology versus socialization remain a topic of ongoing study in science. The preponderance of evidence attests to the notion that sexual differentiation processes are at least partially hormonally mediated, with high levels of prenatal androgens facilitating male-typed and inhibiting female-typed behaviors. In individuals with Disorders/Differences of Sex Development (DSD), hormonal profiles or sensitivities have been altered due to genetic influences, presumably affecting gender(ed) activity interests as well as gender identity development in a minority of the affected population. While continued postnatal androgen exposure in a number of DSD syndromes has been associated with higher rates of gender dysphoria and gender change, the role of a number of mediating and moderating factors, such as initial gender assignment, syndrome severity and clinical management remains largely unclear. Limited investigations of the associations between these identified influences and gendered development outcomes impede optimization of clinical care. Participants with DSD (n=123), recruited in the context of a Dutch multi-center follow-up audit, were divided in subgroups reflecting prenatal androgen exposure, genital appearance at birth and gender of rearing. Recalled childhood play and playmate preferences, gender identity and sexual orientation were measured with questionnaires and semi-structured interviews. Data were compared to those of control male (n=46) and female participants (n=79). The findings support that (a) prenatal androgen exposure has large effects on (gendered) activity interests, but to a much lesser extent on sexual orientation and that (b) initial gender of rearing remains a better predictor of gender identity contentedness than prenatal androgen exposure, beyond syndrome severity and medical treatment influences. Nonetheless, 3.3% of individuals with DSD in our

  10. Current problems in the first-line treatment of metastatic breast cancer: focus on the role of docetaxel

    Directory of Open Access Journals (Sweden)

    Filippo Montemurro

    2010-09-01

    Full Text Available Metastatic breast cancer is a very heterogeneous disease, both from a clinical and a biological point of view. Despite being still incurable, the expanding therapeutic repertoire has determined a progressive increase in median survival. We describe the clinical course of a 67-year-old woman with a locally advanced, hormone-receptor positive breast cancer with synchronous liver metastases. Single-agent docetaxel at the dose of 100 mg/m2 for 8 cycles determined a pathological complete remission in the breast and a near complete remission of liver metastases. After more than 4 years from diagnosis, the patient is alive and without signs of tumour progression. Based on this clinical case, we discuss management issues like the choice of the initial treatment, the use of monochemotherapy vs polychemotherapy, the worth of surgery of the primary tumour in patients with stage IV disease, and the issue of maintenance endocrine therapy. Furthermore, we reviewed the pivotal role of docetaxel in the management of advanced breast cancer. Whether monochemotherapy or polychemotherapy is felt to be an adequate choice in the clinical practice, docetaxel qualifies as one of the most active and manageable agents. Single agent activity ranging from 20-48% in terms of response rate has been reported in several clinical trials in patients treated in various clinical settings. Docetaxel-based combinations with other cytotoxic agents have become established in the first line treatment both in patients with anthracycline-resistant and anthracycline-sensitive metastatic breast cancer. Finally, docetaxel has been shown to be an optimal companion drug for biologically targeted agents like trastuzumab or bevacizumab, resulting in further treatment options.

  11. Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart.

    Science.gov (United States)

    Klein, Michael G; Shou, Matie; Stohlman, Jayna; Solhjoo, Soroosh; Haigney, Myles; Tidwell, Richard R; Goldstein, Robert E; Flagg, Thomas P; Haigney, Mark C

    2017-08-01

    The failing heart exhibits an increased arrhythmia susceptibility that is often attributed to action potential (AP) prolongation due to significant ion channel remodeling. The inwardly rectifying K + current (I K1 ) has been reported to be reduced, but its contribution to shaping the AP waveform and cell excitability in the failing heart remains unclear. The purpose of this study was to define the effect of I K1 suppression on the cardiac AP and excitability in the normal and failing hearts. We used electrophysiological and pharmacological approaches to investigate I K1 function in a swine tachy-pacing model of heart failure (HF). Terminal repolarization of the AP (TRAP; the time constant of the exponential fit to terminal repolarization) was markedly prolonged in both myocytes and arterially perfused wedges from animals with HF. TRAP was increased by 54.1% in HF myocytes (P < .001) and 26.2% in HF wedges (P = .014). The increase in TRAP was recapitulated by the potent and specific I K1 inhibitor, PA-6 (pentamidine analog 6), indicating that I K1 is the primary determinant of the final phase of repolarization. Moreover, we find that I K1 suppression reduced the ratio of effective refractory period to AP duration at 90% of repolarization, permitting re-excitation before full repolarization, reduction of AP upstroke velocity, and likely promotion of slow conduction. Using an objective measure of terminal repolarization, we conclude that I K1 is the major determinant of the terminal repolarization time course. Moreover, suppression of I K1 prolongs repolarization and reduces postrepolarization refractoriness without marked effects on the overall AP duration. Collectively, these findings demonstrate how I K1 suppression may contribute to arrhythmogenesis in the failing heart. Published by Elsevier Inc.

  12. Current trends in platelet transfusions practice: The role of ABO-RhD and human leukocyte antigen incompatibility

    Directory of Open Access Journals (Sweden)

    Serena Valsami

    2015-01-01

    Full Text Available Platelet transfusions have contributed to the revolutionary modern treatment of hypoproliferative thrombocytopenia. Despite the long-term application of platelet transfusion in therapeutics, all aspects of their optimal use (i.e., in cases of ABO and/or Rh (D incompatibility have not been definitively determined yet. We reviewed the available data on transfusion practices and outcome in ABO and RhD incompatibility and platelet refractoriness due to anti-human leukocyte antigen (HLA antibodies. Transfusion of platelets with major ABO-incompatibility is related to reduced posttransfusion platelet (PLT count increments, compared to ABO-identical and minor, but still are equally effective in preventing clinical bleeding. ABO-minor incompatible transfusions pose the risk of an acute hemolytic reaction of the recipient that is not always related to high anti-A, B donor titers. ABO-identical PLT transfusion seems to be the most effective and safest therapeutic strategy. Exclusive ABO-identical platelet transfusion policy could be feasible, but alternative approaches could facilitate platelet inventory management. Transfusion of platelets from RhD positive donors to RhD negative patients is considered to be effective and safe though is associated with low rate of anti-D alloimmunization due to contaminating red blood cells. The prevention of D alloimmunization is recommended only for women of childbearing age. HLA alloimmunization is a major cause of platelet refractoriness. Managing patients with refractoriness with cross-matched or HLA-matched platelets is the current practice although data are still lacking for the efficacy of this practice in terms of clinical outcome. Leukoreduction contributes to the reduction of both HLA and anti-D alloimmunization.

  13. At the Turning Point of the Current Techno-Economic Paradigm: Commons-Based Peer Production, Desktop Manufacturing and the Role of Civil Society in the Perezian Framework

    Directory of Open Access Journals (Sweden)

    Vasilis Kostakis

    2013-01-01

    Full Text Available Following the theory of techno-economic paradigm shifts (TEPS, this paper calls attention to the phenomenon of Commons-based peer production (CBPP. In the context of the current paradigm, it argues that civil society can play an important role in creating favourable conditions for a more sustainable global knowledge society. Approaching tentatively the ways in which 3D printing and other desktop manufacturing technologies can be used in CBPP, it also explores the ways in which the partnership with the state may provide a supportive innovative institutional basis for taking the maximum advantage of the emerging synergies in the vein of TEPS theory.

  14. Federal Government Electronic Bulletin Boards: An Assessment with Policy Recommendations.

    Science.gov (United States)

    Bertot, John Carlo; McClure, Charles R.

    1993-01-01

    Identifies and analyzes federal government electronic bulletin boards; assesses the types of information available to users, including costs and technological access issues; discusses federal information policy; and considers the role of federal bulletin boards in accessing and managing electronic government information. (Contains 29 references.)…

  15. Federalism and educational policies in Brazil: contexts and ruptures

    Directory of Open Access Journals (Sweden)

    Rodrigo Ferreira Rodrigues

    2018-01-01

    Full Text Available This article aims to analyze the complexity of the Brazilian federal arrangement and the design of educational policies through the correlation of forces and disputes between spaces and institutional tensions that configure the current and recent context in the educational policies of Brazil. It is a theoretical and documentary study and had as its axis of analysis the tensions and ruptures that had as a background (direct or indirect the National Education System and in its contribution the very system of collaboration, as specific policies of the Brazilian cooperative pact. Thus, we emphasize the role of social participation in the implementation of EC 59/2009, in the National Education Conferences (from 2010 to 2018 and in the constitution of SASE as spaces of agreement and broad and democratic dialogue. Based on this context, it was possible to highlight the ruptures with the process of affirmation of cooperative federalism in guaranteeing the right to quality public education with social and democratic participation, evidencing the necessary strengthening of federal pacts, in the face of the challenges facing the federalism and effectiveness of educational policies in Brazil.

  16. Environmental federalism and US climate change policy

    Energy Technology Data Exchange (ETDEWEB)

    Jaeger, L.M. [Bracewell and Patterson, LLP (United States)

    2004-07-01

    Environmental disputes involving states over the proper state and federal roles have grown in number and magnitude over the last several years, with many disputes engaging dozens of states. States with competing views are fully engaged in the ongoing debate over climate change, a textbook case for testing the contours of environmental federalism. The issue has all the necessary components: transboundary environmental impacts; competing state economic and environmental interests; state self-interest; disagreement on first principles including what is the proper role of the states; and a somewhat ill-defined federal role. With those qualities, one would expect the federal government to step in and regulate. Instead, the federal government has declined to regulate, inviting a national discourse on whether and how to reduce greenhouse gas (GHG) emissions. As of Spring 2004, twenty-eight states have launched or are planning initiatives, some of which will directly regulate sources of GHG emissions. As these programs take root, pressure will build for a greater federal role. This paper will advance the position that even with this building momentum, the federal government is not likely to emulate state programs that mandate CO{sub 2} emission reductions. In the face of high national cost, uncertain environmental benefits, and a history of federal non-regulatory action, federal regulation at this time appears to be a remote possibility. State efforts to address global climate change add value to the debate, but they do not create the cocoon of consensus the federal government seeks before launching mandatory programs of this magnitude. The more likely scenario is that the federal government will continue on its present course, funding research and development, investing in energy efficient technologies, and supporting voluntary measures. Under this scenario, states and the private sector would continue to function as the 'laboratories' to develop new ideas to

  17. Environmental federalism and US climate change policy

    International Nuclear Information System (INIS)

    Jaeger, L.M.

    2004-01-01

    Environmental disputes involving states over the proper state and federal roles have grown in number and magnitude over the last several years, with many disputes engaging dozens of states. States with competing views are fully engaged in the ongoing debate over climate change, a textbook case for testing the contours of environmental federalism. The issue has all the necessary components: transboundary environmental impacts; competing state economic and environmental interests; state self-interest; disagreement on first principles including what is the proper role of the states; and a somewhat ill-defined federal role. With those qualities, one would expect the federal government to step in and regulate. Instead, the federal government has declined to regulate, inviting a national discourse on whether and how to reduce greenhouse gas (GHG) emissions. As of Spring 2004, twenty-eight states have launched or are planning initiatives, some of which will directly regulate sources of GHG emissions. As these programs take root, pressure will build for a greater federal role. This paper will advance the position that even with this building momentum, the federal government is not likely to emulate state programs that mandate CO 2 emission reductions. In the face of high national cost, uncertain environmental benefits, and a history of federal non-regulatory action, federal regulation at this time appears to be a remote possibility. State efforts to address global climate change add value to the debate, but they do not create the cocoon of consensus the federal government seeks before launching mandatory programs of this magnitude. The more likely scenario is that the federal government will continue on its present course, funding research and development, investing in energy efficient technologies, and supporting voluntary measures. Under this scenario, states and the private sector would continue to function as the 'laboratories' to develop new ideas to improve energy

  18. Federal environmental inspections handbook

    International Nuclear Information System (INIS)

    1991-10-01

    This Federal Environmental Inspection Handbook has been prepared by the Department of Energy (DOE), Office of Environmental Guidance, RCRA/CERCLA Division (EH-231). It is designed to provide DOE personnel with an easily accessible compilation of the environmental inspection requirements under Federal environmental statutes which may impact DOE operations and activities. DOE personnel are reminded that this Handbook is intended to be used in concert with, and not as a substitute for, the Code of Federal Regulations (CFR). Federal Register (FR), and other applicable regulatory documents

  19. Bioethics Symposium: The ethical food movement: What does it mean for the role of science and scientists in current debates about animal agriculture?

    Science.gov (United States)

    Croney, C C; Apley, M; Capper, J L; Mench, J A; Priest, S

    2012-05-01

    Contemporary animal agriculture is increasingly criticized on ethical grounds. Consequently, current policy and legislative discussions have become highly controversial as decision makers attempt to reconcile concerns about the impacts of animal production on animal welfare, the environment, and on the efficacy of antibiotics required to ensure human health with demands for abundant, affordable, safe food. Clearly, the broad implications for US animal agriculture of what appears to be a burgeoning movement relative to ethical food production must be understood by animal agriculture stakeholders. The potential effects of such developments on animal agricultural practices, corporate marketing strategies, and public perceptions of the ethics of animal production must also be clarified. To that end, it is essential to acknowledge that people's beliefs about which food production practices are appropriate are tied to diverse, latent value systems. Thus, relying solely on scientific information as a means to resolve current debates about animal agriculture is unlikely to be effective. The problem is compounded when scientific information is used inappropriately or strategically to advance a political agenda. Examples of the interface between science and ethics in regards to addressing currently contentious aspects of food animal production (animal welfare, antimicrobial use, and impacts of animal production practices on the environment) are reviewed. The roles of scientists and science in public debates about animal agricultural practices are also examined. It is suggested that scientists have a duty to contribute to the development of sound policy by providing clear and objectively presented information, by clarifying misinterpretations of science, and by recognizing the differences between presenting data vs. promoting their own value judgments in regard to how and which data should be used to establish policy. Finally, the role of the media in shaping public opinions

  20. 76 FR 31395 - Federal Acquisition Regulation; Sustainable Acquisition

    Science.gov (United States)

    2011-05-31

    ..., landfill gas, ocean (including tidal, wave, current, and thermal), municipal solid waste, or new... maintenance costs; (4) Ensure that rehabilitation of Federally-owned historic buildings utilizes best...

  1. Environmental Enforcement of Federal Agencies: A Struggle for Power under the ’New Federalism

    Science.gov (United States)

    1990-01-01

    Separation of Powers Dillemma ............ . 55 III. Establishment of Goals...federal power. Currently that countervailing federal 54 power does not exist because of the restraints imposed on EPA. 16 d. Separation of Powers Dilemma...structure and implies a necessary separation of powers . In Federalist 48 Madison discussed the connections necessary to maintain a proper separation of powers :

  2. Teaching about American Federal Democracy.

    Science.gov (United States)

    Schechter, Stephen L., Ed.

    Ten essays discuss federal democracy, the form of government of the United States. The first essay discusses the origins of American federalism. The second examines why we have a federal system, the functions federalism serves, and the consequences of federalism for the American political system. Federalism in the Constitution and constitutional…

  3. Current role of resurfacing lasers.

    Science.gov (United States)

    Hantash, B M; Gladstone, H B

    2009-06-01

    Resurfacing lasers have been the treatment of choice for diminishing rhytids and tightening skin. The carbon dioxide and erbium lasers have been the gold and silver standards. Despite their effectiveness, these resurfacing lasers have a very high risk profile including scarring, hyperpigmentation and hypopigmentation. Because of these side effects, various practitioners have tried alternative settings for these lasers as well as alternative wavelengths, particularly in the infrared spectrum. These devices have had less downtime, but their effectiveness has been limited to fine wrinkles. As with selective photothemolysis, a major advance in the field has been fractionated resurfacing which incorporates grids of microthermal zones that spares islands of skin. This concept permits less tissue damage and quicker tissue regeneration. Initially, fractionated resurfacing was limited to the nonablative mid-infrared spectrum. These resurfacing lasers is appropriate for those patients with acne scars, uneven skin tone, mild to moderate photodamage, and is somewhat effective for melasma. Importantly, because there is less overall tissue damage and stimulation of melanocytes, these lasers can be used in darker skin types. Downtime is 2-4 days of erythema and scaling. Yet, these nonablative fractionated devices required 5-6 treatments to achieve a moderate effect. Logically, the fractionated resurfacing has now been applied to the CO2 and the Erbium:Yag lasers. These devices can treat deeper wrinkles and tighten skin. Downtime appears to be 5-7 days. The long term effectiveness and the question of whether these fractionated devices will approach the efficacy of the standard resurfacing lasers is still in question. Ultimately either integrated devices which may use fractionated resurfacing, radiofrequency and a sensitizer, or combining different lasers in a single treatment may prove to be the most effective in reducing rhtyides, smoothing the skin topography and tightening the skin envelope.

  4. [Current role of conservative surgery].

    Science.gov (United States)

    Barri-Soldevila, Pere N; Vázquez, Alberto

    2013-07-01

    It is not easy to establish the true impact of fibroids on fertility. Fibroidectomy in sterile patients with subserosal fibroids does not offer the best results for patients with in situ fibroids. Women with intramural fibroids appear to present reduced fertility and increased miscarriage rates, compared with women without fibroids. However, fibroidectomy does not always reverse this effect (does not increase the clinical pregnancy or "take-home baby" rates), but the quality of the studies is still poor. Fibroids with a submucosal component significantly decrease implantation and pregnancy rates with regard to sterile controls. Fibroid exeresis clearly improves fertility results. There is a need for better quality studies aimed at assessing the impact of intramural fibroids, with a special focus on factors such as size, number and proximity to the endometrium. The majority of cases can be treated endoscopically. This procedure needs properly trained teams who monitor their results and who are able to offer the same guarantees that laparotomy affords, both in terms of the surgical technique and the patients' obstetric future. Laparoscopic fibroidectomy offers results comparable to laparotomy and minimizes the formation of adhesions, blood loss, hospital stay and the time to return to work. For sterile patients, laparoscopic fibroidectomy may be the first choice therapy. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  5. CMS Use of a Data Federation

    CERN Document Server

    Bloom, Kenneth Arthur

    2014-01-01

    CMS is in the process of deploying an Xrootd based infrastructure to facilitate a global data federation. The services of the federation are available to export data from half the physical capacity and the majority of sites are configured to read data over the federation as a back-up. CMS began with a relatively modest set of use-cases for recovery of failed local file opens, debugging and visualization. CMS is finding that the data federation can be used to support small scale analysis and load balancing. Looking forward we see potential in using the federation to provide more flexibility in the location workflows are executed as the differenced between local access and wide area access are diminished by optimization and improved networking. In this presentation we will discuss the application development work and the facility deployment work, the use-cases currently in production, and the potential for the technology moving forward.

  6. Dimensions of Modern Federalism.

    Science.gov (United States)

    Williams, Robert F.; And Others

    1995-01-01

    Encapsulates a series of brief essays exploring different aspects of modern federalism. Issues include further protection of individual rights extended through state constitutions and federalism and the world economy. Authors include Robert F. Williams, Earl H. Fry, and Daniel J. Elazar. (MJP)

  7. Depression among current, former, and never smokers from 2005 to 2013: The hidden role of disparities in depression in the ongoing tobacco epidemic.

    Science.gov (United States)

    Goodwin, Renee D; Wall, Melanie M; Garey, Lorra; Zvolensky, Michael J; Dierker, Lisa; Galea, Sandro; Gbedemah, Misato; Weinberger, Andrea H; Williams, Jill M; Hu, Mei-Chen; Hasin, Deborah S

    2017-04-01

    After declining sharply for many years, the prevalence of smoking has remained fairly stable over the past decade. One possible explanation is that there has been an increase in the prevalence of barriers to cessation, like depression, among remaining smokers. To estimate changes in the prevalence of depression among current, former and never smokers in the United States (U.S.) population from 2005 to 2013 overall and by age, gender, and income. Data were drawn from the National Household Survey on Drug Use (NSDUH), an annual cross-sectional study of persons ages 12 and over (N=496,805). The prevalence of past 12-month depression was examined annually among current (past 12-month), former (not past 12-month), and lifetime non-smokers from 2005 to 2013. Data were re-analyzed stratified by age, gender, and household income, and adjusted for demographics. Depression appears to have significantly increased in the United States from 2005 to 2013 among current, former, and never smokers. Depression prevalence increased among current smokers overall, but the increase among former and never smokers was even more prominent. Striking temporal changes emerged by age, gender and income. Specifically, (1) depression increased significantly among current smokers aged 12-17 (from 16% to 22%, p-value=0.0002) and the prevalence was consistently more than twice as high as that of never smokers; (2) depression increased among male smokers (6.19%-7.82%, p-value=0.0099); (3) depression increased significantly among smokers in the highest income group (6.36% to 8.91%, p-value=0.0400). Throughout this period, the prevalence of depression among current smokers was consistently twice as high as among former and never smokers. Public health efforts aimed at decreasing the prevalence of smoking should take depression into account, a common and modifiable barrier whose treatment may help to increase successful smoking cessation. Future work is needed to disentangle the role of smoking and

  8. Vorapaxar: The Current Role and Future Directions of a Novel Protease-Activated Receptor Antagonist for Risk Reduction in Atherosclerotic Disease.

    Science.gov (United States)

    Gryka, Rebecca J; Buckley, Leo F; Anderson, Sarah M

    2017-03-01

    Despite the current standard of care, patients with cardiovascular disease remain at a high risk for recurrent events. Inhibition of thrombin-mediated platelet activation through protease-activated receptor-1 antagonism may provide reductions in atherosclerotic disease beyond those achievable with the current standard of care. Our primary objective is to evaluate the clinical literature regarding the role of vorapaxar (Zontivity™) in the reduction of cardiovascular events in patients with a history of myocardial infarction and peripheral artery disease. In particular, we focus on the potential future directions for protease-activating receptor antagonists in the treatment of a broad range of atherosclerotic diseases. A literature search of PubMed and EBSCO was conducted to identify randomized clinical trials from August 2005 to June 2016 using the search terms: 'vorapaxar', 'SCH 530348', 'protease-activated receptor-1 antagonist', and 'Zontivity™'. Bibliographies were searched and additional resources were obtained. Vorapaxar is a first-in-class, protease-activated receptor-1 antagonist. The Thrombin Receptor Antagonist for Clinical Event Reduction (TRACER) trial did not demonstrate a significant reduction in a broad primary composite endpoint. However, the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P-TIMI 50) trial examined a more traditional composite endpoint and found a significant benefit with vorapaxar. Vorapaxar significantly increased bleeding compared with standard care. Ongoing trials will help define the role of vorapaxar in patients with peripheral arterial disease, patients with diabetes mellitus, and other important subgroups. The use of multivariate modeling may enable the identification of subgroups with maximal benefit and minimal harm from vorapaxar. Vorapaxar provides clinicians with a novel mechanism of action to further reduce the burden of ischemic heart disease. Identification of

  9. A review of the potential therapeutic role of statins in the treatment of Alzheimer’s disease: current research and opinion

    Directory of Open Access Journals (Sweden)

    Mitchell AJ

    2013-01-01

    Full Text Available Álvaro Sánchez-Ferro,1–4 Julián Benito-León,1–3 Alex J Mitchell,5 Félix Bermejo-Pareja1–31Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain; 2Department of Medicine, Complutense University, Madrid, Spain; 3Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain; 4Instituto de Salud Carlos III, Madrid, Spain; 5Department of Psycho-oncology, Leicestershire Partnership NHS Trust and University of Leicester, Leicester, UKAbstract: Alzheimer’s disease is one of the most prevalent neurodegenerative disorders. However, there is no current treatment, which definitively influences disease progression over a sustained period. Numerous studies linking an increase in serum cholesterol, mainly during midlife, with the pathogenic process of Alzheimer’s disease have been published. Therefore, the role of statins as a therapy in this disorder may be of great interest. The aim of the present review is to summarize of the role of statins in the treatment of Alzheimer’s disease.Keywords: animal models, epidemiology, HMGCoA-inhibitors, clinical trials, prevention, cognitive function

  10. The Role That Web 2.0 Currently Has and Could Have in the Future in Supporting the Teaching of ICT Design for All

    Science.gov (United States)

    Mitrea, Paulina; Mitrea, Delia

    The main objective of the article is to highlight the role that Web2.0 currently has and could have in the future in supporting the teaching of ICT Design for All. According to this, first the concepts of Web2.0 and eLearning2.0 are clarified and connected. The new way of thinking about eLearning being inspired by the emergence of Web2.0, the term eLearning2.0 was introduced to identify a new paradigm. So, eLearning 2.0, by contrast to eLearning1.0 is built around collaboration, also eLearning2.0 assumes that knowledge is socially constructed. Related to the role of Web2.0 in supporting the teaching of ICT Design for All, the 4 steps involved by the ICT Design For All Teaching Principles are presented and detailed. Finally, some real world examples are shown, as evidence of how the new methods of communication offered by Web2.0 can be used to support students as they learn about Design for All.

  11. Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yao [Jonas Children’s Vision Care, and Bernard and Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology and Pathology & Cell Biology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital/Columbia University, New York, United States; Zhang, Yu [Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, United States; Xu, Yu [Jonas Children’s Vision Care, and Bernard and Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology and Pathology & Cell Biology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital/Columbia University, New York, United States; Department of Ophthalmology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Kittredge, Alec [Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, United States; Ward, Nancy [Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, United States; Chen, Shoudeng [Molecular Imaging Center, Department of Experimental Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China; Tsang, Stephen H. [Jonas Children’s Vision Care, and Bernard and Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology and Pathology & Cell Biology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital/Columbia University, New York, United States; Yang, Tingting [Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, Rochester, United States

    2017-10-24

    Mutations in the human BEST1 gene lead to retinal degenerative diseases displaying progressive vision loss and even blindness. BESTROPHIN1, encoded by BEST1, is predominantly expressed in retinal pigment epithelium (RPE), but its physiological role has been a mystery for the last two decades. Using a patient-specific iPSC-based disease model and interdisciplinary approaches, we comprehensively analyzed two distinct BEST1 patient mutations, and discovered mechanistic correlations between patient clinical phenotypes, electrophysiology in their RPEs, and the structure and function of BESTROPHIN1 mutant channels. Our results revealed that the disease-causing mechanism of BEST1 mutations is centered on the indispensable role of BESTROPHIN1 in mediating the long speculated Ca2+-dependent Cl- current in RPE, and demonstrate that the pathological potential of BEST1 mutations can be evaluated and predicted with our iPSC-based ‘disease-in-a-dish’ approach. Moreover, we demonstrated that patient RPE is rescuable with viral gene supplementation, providing a proof-of-concept for curing BEST1-associated diseases.

  12. Current evidence for a role of GLP-1 in Roux-en-Y gastric bypass-induced remission of type 2 diabetes

    DEFF Research Database (Denmark)

    Rhee, Nicolai Alexander; Vilsbøll, T; Knop, F K

    2012-01-01

    Weight-reducing surgical procedures such as Roux-en-Y gastric bypass (RYGB) have proven efficient as means of decreasing excess body weight. Furthermore, some studies report that up to 80% of patients with type 2 diabetes mellitus (T2DM) undergoing RYGB experience complete remission of their T2DM......-induced remission of T2DM are lacking. This article critically evaluates the current evidence for a role of GLP-1 in RYGB-induced remission of T2DM.......Weight-reducing surgical procedures such as Roux-en-Y gastric bypass (RYGB) have proven efficient as means of decreasing excess body weight. Furthermore, some studies report that up to 80% of patients with type 2 diabetes mellitus (T2DM) undergoing RYGB experience complete remission of their T2DM...... antidiabetic effects of GLP-1 are thought to be key mediators in RYGB-induced remission of T2DM. However, the published studies on the impact of RYGB on GLP-1 secretion are few, small and often not controlled properly. Furthermore, mechanistic studies delineating the role of endogenous GLP-1 secretion in RYGB...

  13. Federalism, Agenda Setting, and the Dynamics of Federal Education Policy.

    Science.gov (United States)

    Manna, Paul

    This paper is part of a larger project on agenda setting in the U.S. federal system and the development of the federal education agenda since 1965. Two questions motivate the paper, one theoretical and the other empirical: (1) how does federalism affect the federal agenda?; and (2) what explains the development of federal involvement in K-12…

  14. Projected changes to South Atlantic boundary currents and confluence region in the CMIP5 models: the role of wind and deep ocean changes

    Science.gov (United States)

    Pontes, G. M.; Gupta, A. Sen; Taschetto, A. S.

    2016-09-01

    The South Atlantic (SA) circulation plays an important role in the oceanic teleconnections from the Indian, Pacific and Southern oceans to the North Atlantic, with inter-hemispheric exchanges of heat and salt. Here, we show that the large-scale features of the SA circulation are projected to change significantly under ‘business as usual’ greenhouse gas increases. Based on 19 models from the Coupled Model Intercomparison Project phase 5 there is a projected weakening in the upper ocean interior transport (stress curl over this region. The reduction in ocean interior circulation is largely compensated by a decrease in the net deep southward ocean transport (>1000 m), mainly related to a decrease in the North Atlantic deep water transport. Between 30° and 40°S, there is a consistent projected intensification in the Brazil current strength of about 40% (30%-58% interquartile range) primarily compensated by an intensification of the upper interior circulation across the Indo-Atlantic basin. The Brazil-Malvinas confluence is projected to shift southwards, driven by a weakening of the Malvinas current. Such a change could have important implications for the distribution of marine species in the southwestern SA in the future.

  15. Role of food preoccupation and current dieting in the associations of parental feeding practices to emotional eating in young adults: A moderated mediation study.

    Science.gov (United States)

    Williams, Natalie A; Dev, Dipti A; Hankey, Maren; Blitch, Kimberly

    2017-04-01

    Parental feeding practices reflecting coercive control are related to children's later eating behaviors, but the mechanisms underlying these effects remain poorly understood. This study examined the relationships between recalled childhood experiences of parental pressure to eat and restriction and current food preoccupation, dieting, and emotional eating in a racially diverse sample of college students (N = 711). Results revealed that parental restriction, but not pressure to eat, was associated with more emotional eating (r = 0.18, p Food preoccupation mediated the association between restriction and emotional eating (95% CI [3.6495-7.2231]); however, a moderated mediation model revealed that the strength of the indirect effect of restrictive feeding on emotional eating through food preoccupation was significantly different for dieters and non-dieters (index of moderated mediation = 1.79, Boot SE = 0.79; 95% bias-corrected bootstrap CI [-3.5490 to -0.4515]). These findings provide unique insight into the mechanisms linking parental feeding practices with emotional eating in young adulthood. Future studies attempting to clarify the processes through which child feeding practices impact later eating behaviors should consider the role of current dieting. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Modulation of neural activity in the temporoparietal junction with transcranial direct current stimulation changes the role of beliefs in moral judgment

    Directory of Open Access Journals (Sweden)

    Hang eYe

    2015-12-01

    Full Text Available Judgments about whether an action is morally right or wrong typically depend on our capacity to infer the actor’s beliefs and the outcomes of the action. Prior neuroimaging studies have found that mental state (e.g., beliefs, intentions attribution for moral judgment involves a complex neural network that includes the temporoparietal junction (TPJ. However, neuroimaging studies cannot demonstrate a direct causal relationship between the activity of this brain region and mental state attribution for moral judgment. In the current study, we used transcranial direct current stimulation (tDCS to transiently alter neural activity in the TPJ. The participants were randomly assigned to one of three stimulation treatments (right anodal/left cathodal tDCS, left anodal/right cathodal tDCS, or sham stimulation. Each participant was required to complete two similar tasks of moral judgment before receiving tDCS and after receiving tDCS. We studied whether tDCS to the TPJ altered mental state attribution for moral judgment. The results indicated that restraining the activity of the right temporoparietal junction (RTPJ or the left the temporoparietal junction (LTPJ decreased the role of beliefs in moral judgments and led to an increase in the dependence of the participants’ moral judgments on the action’s consequences. We also found that the participants exhibited reduced reaction times both in the cases of intentional harms and attempted harms after receiving right cathodal/left anodal tDCS to the TPJ. These findings inform and extend the current neural models of moral judgment and moral development in typically developing people and in individuals with neurodevelopmental disorders such as autism.

  17. A compreensão dos operadores de direito do Distrito Federal sobre o usuário de drogas na vigência da nova lei The understanding of law professionals from the Federal District about drug users under the current new law

    Directory of Open Access Journals (Sweden)

    Luiza Barros Santoucy

    2010-04-01

    Full Text Available O usuário de drogas tem recebido tratamentos contraditórios que promovem sua estigmatização e clandestinidade e limitam a compreensão do fenômeno. O objetivo foi investigar como Promotores e Juízes estão entendendo e aplicando a nova lei que legisla sobre a conduta de usar e portar drogas no Brasil. Onze operadores do Direito do Distrito Federal (DF participaram de entrevistas semi-estruturadas divididas em três eixos: a visão em relação ao usuário de droga; como a lei vem sendo aplicada; e como concebe o trabalho da equipe multidisciplinar. As respostas demonstraram posições muito heterogêneas, denotando não haver ainda unanimidade quanto à compreensão da nova lei: se por um lado há uma crença compartilhada de que o uso de drogas é um problema de saúde pública, por outro, acredita-se que o usuário deve receber uma punição por seu ato ilegal. Um diálogo interdisciplinar efetivo permitiria uma atuação eficaz e reflexiva visando a beneficiar as pessoas que chegam à justiça.Drugs users have been receiving contradictory treatments thereby promoting their stigma besides hiding and limiting the understanding of the phenomenon. The objective of this study was to investigate how the District Attorneys and Judges are considering and applying the new law which legislates on the conduct of drug use in Brazil. Eleven Law professionals from the Federal District participated in semi-structured interviews divided in three areas: the point of view in relation to the user of drugs, how the law is being applied, and how they conceive the work of the multidisciplinary teams. The results showed very heterogeneous positions, showing that there is no unanimity on the understanding of the new law. For some, there is a shared belief that drugs abuse is a public health problem, for others, it is believed that the user must receive a punishment for his/her illegal act. An effective and efficient interdisciplinary dialogue should allow a

  18. Improving Federal Response to Drought.

    Science.gov (United States)

    Wilhite, Donald A.; Rosenberg, Norman J.; Glantz, Michael H.

    1986-03-01

    Severe and widespread drought occurred over a large portion of the United States between 1974 and 1977. Impacts on agriculture and other industries, as well as local water supplies, were substantial. The federal government responded with forty assistance programs administered by sixteen federal agencies. Assistance was provided primarily in the form of loans and grants to people, businesses and governments experiencing hardship caused by drought. The total cost of the program is estimated at $7-8 billion.Federal response to the mid-1970s drought was largely untimely, ineffective and poorly coordinated. Four recommendations are offered that, if implemented, would improve future drought assessment and response efforts: 1) reliable and timely informational products and dissemination plans; 2) improved impact assessment techniques, especially in the agricultural sector, for use by government to identify periods of enhanced risk and to trigger assistance measures; 3) administratively centralized drought declaration procedures that are well publicized and consistently applied; and 4) standby assistance measures that encourage appropriate levels of risk management by producers and that are equitable, consistent and predictable. The development of a national drought plan that incorporates these four items is recommended. Atmospheric scientists have an important role to play in the collection and interpretation of near-real time weather data for use by government decision makers.

  19. The understanding of law professionals from the Federal District about drug users under the current new law / A compreensão dos operadores de direito do Distrito Federal sobre o usuário de drogas na vigência da nova lei

    Directory of Open Access Journals (Sweden)

    Maria Fátima Olivier Sudbrack

    2010-01-01

    Full Text Available Drugs users have been receiving contradictory treatments thereby promoting their stigma besides hiding and limiting the understanding of the phenomenon. The objective of this study was to investigate how the District Attorneys and Judges are considering and applying the new law which legislates on the conduct of drug use in Brazil. Eleven Law professionals from the Federal District participated in semi-structured interviews divided in three areas: the point of view in relation to the user of drugs, how the law is being applied, and how they conceive the work of the multidisciplinary teams. The results showed very heterogeneous positions, showing that there is no unanimity on the understanding of the new law. For some, there is a shared belief that drugs abuse is a public health problem, for others, it is believed that the user must receive a punishment for his/her illegal act. An effective and efficient interdisciplinary dialogue should allow a reflective action aiming at favoring those who come to justice.

  20. Federalism and multilevel governance

    NARCIS (Netherlands)

    van der Wusten, H.; Agnew, J.; Mamadouh, V.; Secor, A.J.; Sharp, J.

    2015-01-01

    Federalism and multilevel governance both emphasize polycentricity in governing arrangements. With their different intellectual pedigrees, these concepts are discussed in two separate sections. Fragments are now increasingly mixed up in hybrid forms of governance that also encompass originally

  1. Federal Medication Terminologies

    Science.gov (United States)

    Federal Medication (FedMed) collaboration of 8 partner agencies agreed on a set of standard, comprehensive, freely and easily accessible FMT terminologies to improve the exchange and public availability of medication information.

  2. ACA Federal Upper Limits

    Data.gov (United States)

    U.S. Department of Health & Human Services — Affordable Care Act Federal Upper Limits (FUL) based on the weighted average of the most recently reported monthly average manufacturer price (AMP) for...

  3. Federal Ballpark Estimator

    Data.gov (United States)

    Office of Personnel Management — The Federal Ballpark E$timate(R) was developed by the Employee Benefit Research Institute(R) and its American Savings Education Council(R) (ASEC(R)) program. It is...

  4. New Mexico Federal Lands

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — This map layer consists of federally owned or administered lands of the United States, Puerto Rico, and the U.S. Virgin Islands. Only areas of 640 acres or more are...

  5. Integrated vs. Federated Search

    DEFF Research Database (Denmark)

    Løvschall, Kasper

    2009-01-01

    Oplæg om forskelle og ligheder mellem integrated og federated search i bibliotekskontekst. Holdt ved temadag om "Integrated Search - samsøgning i alle kilder" på Danmarks Biblioteksskole den 22. januar 2009.......Oplæg om forskelle og ligheder mellem integrated og federated search i bibliotekskontekst. Holdt ved temadag om "Integrated Search - samsøgning i alle kilder" på Danmarks Biblioteksskole den 22. januar 2009....

  6. Information Asymmetry in Federations

    Directory of Open Access Journals (Sweden)

    Alexander Mikhailovich Libman

    2014-12-01

    Full Text Available The paper investigates the problems of information transmission between levels of government in a federal state. The central government in a federation typically faces serious difficulties while collecting information on economic and political situation in the regions. There are two types of problems: lack of incentives for the regions to accurately collect information and strategic manipulation of information, which are discussed in the paper along with possible solutions. In particular, overcoming information asymmetry would require the development of national parties or informal coalitions of bureaucrats and politicians of the center and of the regions, creating incentives for regional politicians to back the successful functioning of the federal level. Furthermore, the paper discusses the issue of «informal decentralization», which emerges as a result of information asymmetry, and its consequences for the functioning of a federal state, including both advantages and disadvantages. We conclude that under information asymmetry the organization of the federation will inevitably turn into an issue of permanent negotiations and bargaining between the center and the regions, which functions as the information acquisition tool for optimal allocation of authorities in a federation

  7. Complying with the Federal Facilities Compliance Act

    International Nuclear Information System (INIS)

    Pavetto, C.S.; Watmore, A.S.

    1994-01-01

    The Federal Facilities Compliance Act (FFCA), signed into law on October 6, 1992, amended the Resource Conservation and Recovery Act (RCRA) to place significant additional environmental compliance responsibilities on federal facilities. The federal government has expressly waived sovereign immunity regarding hazardous waste enforcement action taken against these facilities by the states and the EPA. An exception exists for mixed waste violations. The FFCA defines mixed waste as hazardous waste, as defined by RCRA, combined with source, special nuclear or by-product material that is subject to the Atomic Energy Act of 1954. As the majority owner of mixed waste in the United States, the Department of Energy (DOE) must satisfy several new requirements under the FFCA for their facilities. This paper reviews the FFCA's requirements and how they apply to and may affect the DOE and other federal facilities. Included in the review are responsibilities of federal agencies involved and the role of the EPA and the states. In addition, this paper discusses the intent of the FFCA to encourage development of federal facility agreements (FFA) between federal agencies, the EPA and state environmental regulatory agencies

  8. Energy prices, equalization and federalism

    Energy Technology Data Exchange (ETDEWEB)

    Courchene, T.J. [Queen' s Univ., Kingston, ON (Canada). School of Policy Studies

    2005-10-01

    A rise in oil prices over the last 30 years has shaped the debate on the equalization formula as well as the nature of fiscal federalism. The oil shocks of 1973 and 1979 contributed to the creation of the National Energy Program (NEP) in 1980 and the Energy Pricing and Taxation Agreement (EPTA) between Ottawa and Alberta in 1981. The current surge in oil prices, to recent highs of $70 a barrel has resulted in a new debate on energy pricing, equalization and fiscal frameworks. This article presented a review of the history of oil and federalism, and proposed a remedy to the horizontal fiscal imbalance by allocating the fixed equalization pool in accordance with fiscal capacity disparities relating to non-resource revenues. An interprovincial revenue-sharing pool was suggested for resource revenues, agreed to and operated by the provinces. It was suggested that after the price spike in 1973 in which the price of oil tripled, a key part of the rationale for imposing export taxes on oil equal to the difference between domestic and world prices was that the federal government could subsidize oil imports into eastern Canada and maintain a uniform domestic price across the country. By continuing to subsidize imports and maintaining a domestic price below the world price, the government has been diverting potential energy revenues from energy-rich provinces and transferring them directly to Canadians in terms of subsidized energy prices. It was noted that energy price surges cannot send equalization payments soaring as they did before because of the 2004 Framework Agreement, in which the overall equalization will be increased to $10.9 billion. A 2-tier approach to equalization was presented, in which it was suggested that the $10.9 billion pool should be allocated with fiscal capacity disparities relating to non-resource revenues. The creation of a revenue sharing pool for resource revenues was recommended. It was suggested that the 2 approaches will result in a strategic

  9. Energy prices, equalization and federalism

    International Nuclear Information System (INIS)

    Courchene, T.J.

    2005-01-01

    A rise in oil prices over the last 30 years has shaped the debate on the equalization formula as well as the nature of fiscal federalism. The oil shocks of 1973 and 1979 contributed to the creation of the National Energy Program (NEP) in 1980 and the Energy Pricing and Taxation Agreement (EPTA) between Ottawa and Alberta in 1981. The current surge in oil prices, to recent highs of $70 a barrel has resulted in a new debate on energy pricing, equalization and fiscal frameworks. This article presented a review of the history of oil and federalism, and proposed a remedy to the horizontal fiscal imbalance by allocating the fixed equalization pool in accordance with fiscal capacity disparities relating to non-resource revenues. An interprovincial revenue-sharing pool was suggested for resource revenues, agreed to and operated by the provinces. It was suggested that after the price spike in 1973 in which the price of oil tripled, a key part of the rationale for imposing export taxes on oil equal to the difference between domestic and world prices was that the federal government could subsidize oil imports into eastern Canada and maintain a uniform domestic price across the country. By continuing to subsidize imports and maintaining a domestic price below the world price, the government has been diverting potential energy revenues from energy-rich provinces and transferring them directly to Canadians in terms of subsidized energy prices. It was noted that energy price surges cannot send equalization payments soaring as they did before because of the 2004 Framework Agreement, in which the overall equalization will be increased to $10.9 billion. A 2-tier approach to equalization was presented, in which it was suggested that the $10.9 billion pool should be allocated with fiscal capacity disparities relating to non-resource revenues. The creation of a revenue sharing pool for resource revenues was recommended. It was suggested that the 2 approaches will result in a strategic

  10. Emerging role of nivolumab in the management of patients with non-small-cell lung cancer: current data and future perspectives

    Directory of Open Access Journals (Sweden)

    Feld E

    2017-07-01

    Full Text Available Emily Feld, Leora Horn Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, TN, USA Abstract: Immune-checkpoint inhibitors have become valuable therapies in the treatment of patients with non-small-cell lung cancer (NSCLC. Recent clinical trials have shown promising results with regard to efficacy and toxicity profiles of these agents compared to cytotoxic chemotherapy. Nivolumab was one of the first immune-checkpoint inhibitors to demonstrate clinical activity in patients with NSCLC, and is currently approved in the US for treatment of patients with advanced squamous and nonsquamous NSCLC who have progressed on or after platinum-based chemotherapy. This review provides an update on nivolumab’s pharmacology, safety, and efficacy, as established by the CheckMate trials. We also discuss specific applications and strategies for the use of nivolumab in NSCLC patients, as well as predictive biomarkers and their role in treatment selection. Keywords: nivolumab, non-small-cell lung cancer, immune-checkpoint inhibitor, PD1 

  11. Role of the current density profile on drift wave stability in internal transport barrier reversed magnetic shear experiments at JET and Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Fourment, C; Hoang, G T; Eriksson, L-G; Garbet, X; Litaudon, X; Tresset, G [EURATOM-CEA Association, CEA/DSM/DRFC, CEA Cadarache, 13108 St Paul-lez-Durance (France)

    2003-03-01

    The role of the current density profile on drift wave stability is investigated using a linear electrostatic gyro-kinetic code. The growth rates are shown to have a linear dependence on the normalized temperature gradients above a certain threshold. A parametric study of the threshold shows a dramatic stabilizing effect of negative magnetic shear, especially for large scale instabilities. A set of handy formulae fitting the threshold as a function of the magnetic shear and the safety factor is proposed. Analysis of reversed magnetic shear discharges with internal transport barrier (ITB) in JET shows that ion ITBs can be triggered by the negative magnetic shear in the core of the plasma. Subsequently, the increase of the ExB shearing rate allows for the expansion of the ITB, despite the increase of the linear growth rates due to the temperature gradient peaking. In the case of the electron ITB obtained in the Tore Supra LHEP mode, the central increase of the confinement is associated with the stabilization of large scale trapped electron modes by the negative magnetic shear effect, whereas the steep electron temperature gradient destabilizes the small scale electron temperature gradient modes, which prevent the electron heat transport to reach neoclassical levels.

  12. The Future of Federal Education Policy.

    Science.gov (United States)

    Guthrie, James W.

    1983-01-01

    This article explores the evolution of federal government policy on education during the past 20 years, points out trends likely to influence future policy, and projects possible future responses to these trends. The roles of educational interest groups instrumental in passing the legislation are described. (PP)

  13. Behavioral Insights for Federal Higher Education Policy

    Science.gov (United States)

    Castleman, Ben

    2017-01-01

    The federal role in higher education has grown over the past two decades, and now a new administration has the opportunity to strengthen policies that support students and their colleges and universities. To help inform these decisions, the Urban Institute convened a bipartisan group of scholars and policy advisers to write a series of memos…

  14. Higher Education Accreditation and the Federal Government

    Science.gov (United States)

    Kelchen, Robert

    2017-01-01

    The federal role in higher education has grown over the past two decades, and now a new administration has the opportunity to strengthen policies that support students and their colleges and universities. To help inform these decisions, the Urban Institute convened a bipartisan group of scholars and policy advisers to write a series of memos…

  15. Federalism and Health Care

    Directory of Open Access Journals (Sweden)

    G. Alan Tarr

    2011-10-01

    Full Text Available President Barack Obama proposed a major overhaul of the American healthsystem, and in 2010 the U.S. Congress enacted his proposal, the PatientProtection and Affordable Care Act. Opponents of the Act challenged itsconstitutionality in federal court, claiming that it exceeds the powers grantedto the federal government under the Commerce Clause and the NecessaryProper Clause of the federal Constitution. Some courts have upheldthe law, but others have agreed with the critics, in particular ruling thatthe provision requiring citizens to buy health insurance is unconstitutional.Eventually the U.S. Supreme Court will rule on the issue. This article tracesthe controversy, surveys the interpretation of pertinent constitutional provisionsin past cases, analyzes the constitutional arguments presented byproponents and opponents of the Act, and concludes that the Act is constitutional.

  16. Federation in genomics pipelines: techniques and challenges.

    Science.gov (United States)

    Chaterji, Somali; Koo, Jinkyu; Li, Ninghui; Meyer, Folker; Grama, Ananth; Bagchi, Saurabh

    2017-08-29

    Federation is a popular concept in building distributed cyberinfrastructures, whereby computational resources are provided by multiple organizations through a unified portal, decreasing the complexity of moving data back and forth among multiple organizations. Federation has been used in bioinformatics only to a limited extent, namely, federation of datastores, e.g. SBGrid Consortium for structural biology and Gene Expression Omnibus (GEO) for functional genomics. Here, we posit that it is important to federate both computational resources (CPU, GPU, FPGA, etc.) and datastores to support popular bioinformatics portals, with fast-increasing data volumes and increasing processing requirements. A prime example, and one that we discuss here, is in genomics and metagenomics. It is critical that the processing of the data be done without having to transport the data across large network distances. We exemplify our design and development through our experience with metagenomics-RAST (MG-RAST), the most popular metagenomics analysis pipeline. Currently, it is hosted completely at Argonne National Laboratory. However, through a recently started collaborative National Institutes of Health project, we are taking steps toward federating this infrastructure. Being a widely used resource, we have to move toward federation without disrupting 50 K annual users. In this article, we describe the computational tools that will be useful for federating a bioinformatics infrastructure and the open research challenges that we see in federating such infrastructures. It is hoped that our manuscript can serve to spur greater federation of bioinformatics infrastructures by showing the steps involved, and thus, allow them to scale to support larger user bases. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  17. Empire vs. Federation

    DEFF Research Database (Denmark)

    Gravier, Magali

    2011-01-01

    The article discusses the concepts of federation and empire in the context of the European Union (EU). Even if these two concepts are not usually contrasted to one another, the article shows that they refer to related type of polities. Furthermore, they can be used at a time because they shed light...... on different and complementary aspects of the European integration process. The article concludes that the EU is at the crossroads between federation and empire and may remain an ‘imperial federation’ for several decades. This could mean that the EU is on the verge of transforming itself to another type...

  18. Federalism and health policy.

    Science.gov (United States)

    Nathan, Richard P

    2005-01-01

    This paper presents a cyclical theory of U.S. federalism and social policy: Many social policy initiatives are tested and refined at the state level, especially during conservative periods, and later morph into national policies. The paper describes such federalism cycles and offers an interpretation of why and how they occur, focusing on Medicaid. State activism has preserved and expanded Medicaid through policy innovation and resistance to retrenchment, especially in conservative periods, by taking advantage of the flexibility the program provides. I conclude that Medicaid's incremental/partnership approach is appropriate and feasible to build on for a future expansion of health care coverage.

  19. The Energy Policy Act of 1992 and Executive Order 13149: Proposed compliance strategies and process improvements for federal agencies

    International Nuclear Information System (INIS)

    Helwig, Michael; Deason, Jonathan P.

    2007-01-01

    Under the Energy Policy Act of 1992 (EPAct), 75 percent of Light Duty Vehicle acquisitions by federal agencies must be Alternative Fuel Vehicles (AFVs). EPAct's intent was to reduce United States reliance on oil imports, with federal agencies assuming a leadership role in acquiring AFVs and using alternative fuel in those AFVs. Executive Order (E.O.) 13149, issued in 2000, required federal agencies to reduce petroleum consumption 20 percent relative to a 1999 baseline and use alternative fuels the majority of the time in their AFVs by 2005. Most federal agencies met the EPAct 75 percent acquisition requirement in 2004, however, most will not achieve the petroleum reduction and alternative fuel use requirements. Frequently, federal agencies acquire the relatively expensive AFVs and then fuel those vehicles with gasoline. Besides wasting taxpayer dollars, this approach does not meet the intent of EPAct. It was surmised that federal agencies lack an objective, quantitative methodology for AFV acquisitions and Executive Order 13149 compliance. Several types of optimization models were constructed, using the United States Navy as a test case, for models focusing on EPAct and/or E.O. 13149 compliance. Results of a tiered set of models indicate there are efficiencies that federal agencies could take advantage of when developing EPAct and E.O. 13149 compliance strategies that are not currently being exploited

  20. Sheep farmer opinions on the current and future role of veterinarians in flock health management on sheep farms: A qualitative study

    Science.gov (United States)

    Kaler, Jasmeet; Green, L.E.

    2013-01-01

    A 2009 UK Government report on veterinary expertise in food animal production highlighted that there was insufficient herd health expertise among veterinarians and lack of appropriate business models to deliver veterinary services to the livestock sector. Approximately two thirds of sheep farmers only contact their veterinarian for emergencies and one fifth have all year round contact. The aim of the current study was to understand sheep farmers’ perception, the current and future role of veterinarians in flock health management using qualitative methodology. The eligibility criteria were male farmers with a flock size of at least 200 adult sheep. Seven focus groups of farmers (n = 45) stratified by three regions and two age groups (≤50 and >50) were conducted. Thematic analysis of the discussions indicated that most farmers considered and used their veterinarian as a fire-fighter, whilst other advice was gathered free of charge when the veterinarian was on the farm for other reasons (typically seeing cattle) or by telephone. A small group of farmers were using their veterinarian or a sheep consultant proactively with regular contact and found this financially beneficial. Farmers indicated that the key barriers to using a veterinarian proactively were inconsistent service, high turnover of veterinarians, lack of expertise of sheep farming among veterinarians and concern about independence of advice. Although economics was also mentioned as a key barrier to using veterinarians more proactively, most farmers did not know where they gained and lost income from their flock; there was heavy reliance on the single farm payment scheme (SPS) and very few farmers kept records from which they could investigate where there were inefficiencies in production. Overall sheep farmers considered sheep farming complex and that each farm was unique and that they themselves were the experts to manage their flock. We conclude that there is an impasse: veterinarians might need to

  1. Energy policy and federalism

    Energy Technology Data Exchange (ETDEWEB)

    Thur, L M [ed.

    1981-04-01

    Separate abstracts are prepared for six papers presented as the product of an international seminar on Energy Policy and Federalism in North America. Specially commissioned papers for the seminar are presented along with a summary of the discussions. The summary appears in English, French, and Spanish; the other papers are in English. (MCW)

  2. Federal Emergency Management Agency

    Science.gov (United States)

    ... Term(s): About the Agency Text Messages Federal Interagency Operational Plans Whole Community Technological Hazards Division - Contacts Accessible ASL ... content. Home About Us Download Plug-ins Doing Business with FEMA Privacy ... General Strategic Plan Whitehouse.gov DHS.gov Ready.gov USA.gov ...

  3. Optimized detection and characterization of liver metastases. The role of current MRI contrast agents; Optimierte Detektion und Charakterisierung von Lebermetastasen. Leistungsvermoegen aktueller MRT-Kontrastmittel

    Energy Technology Data Exchange (ETDEWEB)

    Weinrich, J.M.; Well, L.; Bannas, P. [Universitaetsklinikum Hamburg-Eppendorf, Zentrum fuer Radiologie und Endoskopie, Klinik und Poliklinik fuer diagnostische und interventionelle Radiologie und Nuklearmedizin, Hamburg (Germany)

    2017-05-15

    Metastases are the most common malignant lesions of the liver. The presence of liver metastases is an important prognostic factor and is decisive for the further management, especially in patients with colorectal cancer. Detection and characterization of liver metastases as well as differentiation from benign lesions are of high importance and a daily challenge in clinical radiology. Contrast-enhanced magnetic resonance imaging (MRI) has the highest sensitivity in detecting liver metastases. The sensitivity of MRI has been further increased due to the development of liver-specific contrast agents. This article describes the role of extracellular and hepatobiliary contrast agents for the detection and characterization of liver metastases. Moreover, the current knowledge on safety, sequence optimization, transient severe dyspnea and the combination of hepatobiliary with intravascular contrast agents for liver imaging is discussed. (orig.) [German] Metastasen sind die haeufigsten malignen Leberlaesionen. Das Vorhandensein von Lebermetastasen ist entscheidend fuer die Prognose und weitere Therapieplanung von Tumorpatienten, insbesondere von Patienten mit kolorektalen Karzinomen. Die Detektion von Lebermetastasen sowie deren Unterscheidung von anderen Leberlaesionen sind daher von hoechster Bedeutung und stellen eine alltaegliche Herausforderung fuer den Radiologen dar. Die Bildgebung mit der hoechsten Sensitivitaet fuer die Detektion von Lebermetastasen stellt die dynamische kontrastmittelgestuetzte Magnetresonanztomographie (MRT) dar. Die bereits hohe Sensitivitaet der MRT wird durch den Einsatz leberspezifischer Kontrastmittel noch weiter gesteigert. Dieser Artikel beleuchtet die Rolle der aktuellen unspezifischen und leberspezifischen MRT-Kontrastmittel fuer die Detektion und Charakterisierung von Lebermetastasen. Weiterhin werden Erkenntnisse zur Sicherheit, Sequenzoptimierung, zu transienten Atemartefakten und zur Kombination von MRT-Kontrastmitteln fuer die

  4. The OLAP-XML Federation System

    DEFF Research Database (Denmark)

    Yin, Xuepeng; Pedersen, Torben Bach

    2006-01-01

    We present the logical “OLAP-XML Federation System” that enables the external data available in XML format to be used as virtual dimensions. Unlike the complex and time-consuming physical integration of OLAP and external data in current OLAP systems, our system makes OLAP queries referencing fast...

  5. The Role of the Environmental Management Site Specific Advisory Board under the Federal Advisory Committee Act, With Emphasis on the Northern New Mexico Citizens' Advisory Board - 12482

    Energy Technology Data Exchange (ETDEWEB)

    Santistevan, Menice B. [Northern New Mexico Citizens' Advisory Board, 1660 Old Pecos Trail, Suite B, Santa Fe, New Mexico 87505 (United States)

    2012-07-01

    The Environmental Management Site Specific Advisory Board (EM SSAB) is comprised of eight Citizens' Advisory Boards, chartered under the Federal Advisory Committee Act (FACA) by the Assistant Secretary for Environmental Management for the U. S. Department of Energy (DOE). The purpose of the EM SSAB is to provide the DOE with recommendations regarding Environmental Management issues from legacy waste produced at major sites across the DOE Complex. The Northern New Mexico Citizens' Advisory Board (NNMCAB) is the site specific advisory board to the DOE on issues of environmental monitoring, remediation, waste management and long-term stewardship at Los Alamos National Laboratory (LANL). The other boards are located at: Hanford, Idaho, Nevada, Paducah, Portsmouth, Oak Ridge and Savannah River. Using broad citizen outreach and input, the SSAB provides an official mechanism for the citizenry at each of these sites to monitor current activities affecting the region and also to have input into the prioritization of future activities. 'The mission of the EM SSAB is to more directly involve stakeholders in EM Planning and decision-making processes for the nuclear weapons complex cleanup. DOE has various means of involving the public in its planning and decision-making processes; the EM SSAB is only one component of EM's public participation program, and is not intended to be an exclusive means of public participation. It is the policy of DOE and EM to conduct it programs in an open and responsive manner, thereby encouraging and providing the opportunity for public participation in its planning and decision-making processes. EM SSAB members are appointed to a two year term and may serve up to three terms. During this time, members are able to hear many presentation from subject matter experts, attend several site tours at their site and across the DOE complex and are able to express their concerns and give input to the prioritization of clean up at each

  6. EPA perspective on federal facility agreements

    International Nuclear Information System (INIS)

    Grundler, C.

    1988-01-01

    Although DOE's image with Congress and the media concerning environmental compliance may be poor, EPA sees the Department's recent attitude toward the environment as good. DOE and EPA must continue to move forward. In particular, EPA would like to emphasize less study of a problem and more clean-up. Strong, enforceable agreements will allow this goal to be met by letting EPA take more risks in its decision making. Currently EPA is developing an enforcement strategy for Federal facilities. This strategy will address identifying Federal facilities of concern, increasing enforcement and compliance monitoring activities at those facilities, implementing the model agreements, resource planning, and the establishment of an Agency Management System for Federal facilities. There are over 1000 Federal facilities which are listed on the EPA compliance docket. Over 200 Federal facilities are expected to be included on the NPL. Increased EPA attention may increase the ability of the various Federal agencies to obtain the necessary funding. Another subject being addressed by EPA is the liability of government contractors under the environmental statutes. The Agency is developing a GoCo enforcement strategy. In the hazardous waste enforcement program, three criteria are being considered for determining when to proceed against a contractor: Degree of contractor control over the hazardous waste management activity. Who is actually performing the work, and Degree of Departmental cooperation

  7. Why the Federal Reserve Failed to See the Financial Crisis of 2008: The Role of “Macroeconomics†as a Sense making and Cultural Frame

    OpenAIRE

    Fligstein, Neil; Brundage, Jonah S; Schultz, Michael

    2014-01-01

    One of the puzzles about the financial crisis of 2008 is why the regulators were so slow to recognize the impending collapse of the financial system. In this paper, we propose a novel account of what happened. We analyze the meeting transcripts of the Federal Reserve’s main decision-making body, the Federal Open Market Committee (FOMC), to show that they had surprisingly little recognition that a serious economic meltdown was underway even after the collapse of Lehman Brothers on September ...

  8. Federal Recognition of the Rights of Minority Language Groups.

    Science.gov (United States)

    Leibowitz, Arnold H.

    Federal laws, policies, and court decisions pertaining to the civil rights of minority language groups are reviewed, with an emphasis on political, legal, economic, and educational access. Areas in which progress has been made and those in which access is still limited are identified. It is argued that a continuing federal role is necessary to…

  9. F-Word or Blueprint for Institutional Reform? European Integration and the Continued Relevance of Federalism

    Directory of Open Access Journals (Sweden)

    Maximilian Conrad

    2012-12-01

    Full Text Available Federalist thought has historically been an important source of inspiration in European integration. Although the last few decades have witnessed a gradual decline of the concept’s relevance, the most recent developments in the wake of the Eurozone debt crisis have drawn renewed attention to shortcomings in the European Union’s institutional architecture as well as to the feasibility of federal solutions to such institutional shortcomings. This article explores the potential of federalist thought as a blueprint for institutional reform in the EU. Based on a brief introduction to the concept of federalism, the article contextualizes federalism in debates on the democratic deficit, the EU’s sources of legitimacy and the relationship between the union institutions and the member states. If shortcomings in institutional design are the source of the current (and future crises, then closer attention needs to be paid to the costs and benefits of federal reorganization in terms of democracy, legitimacy and sovereignty, particularly from the perspective of small states in the EU. Federal reorganization would not only improve the democratic character of EU decision making, but also strengthen the role of small states in the union. However, it also prompts a number of thorny questions, most importantly regarding the construction of a European demos and its relationship to deeply engrained ideas about the nation state as a more or less natural home of democracy.

  10. Forget a Federal RPS - here's an idea that will work

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-04-15

    Instead of top-down federalism, a carbon portfolio standard would engage states in collaborative federalism in which responsibility for achieving a national goal is shared between Washington and the states consistent with constitutional roles. (author)

  11. Federal report on research 1984

    International Nuclear Information System (INIS)

    1984-01-01

    Current challenges to science and research in the field of scientific-technological innovation are: to safeguard the competitiveness of particularly high-grade and demanding products in those parts of the world market where competition is hard; careful, responsible and at the same time economically reasonable use of nature and the natural resources; scientific and technological efficiency of this country as a partner in the world. The newly oriented research policy approves technical progress and invites top performances. One of the most important immediate problems is the training of qualified young scientists. The federal government views the technological development also in relation to the risks, but is convinced that possible disadvantages can be reduced to become negligible. Information technology, new material, bio and laser technologies, having interindustrial importance, play a part in economy world-wide as key technologies. Besides expenditure for sciences, measures and promotion instruments, the main points of emphasis of promotion as well as the international cooperation are described in detail as to their tasks, structure and volume; furthermore the individual research institutions of the Federal Republic of Germany are pointed out. The statistics appended contain the financial data regarding science expenditure. (HSCH) [de

  12. Study of federal microwave standards

    Energy Technology Data Exchange (ETDEWEB)

    David, L.

    1980-08-01

    Present and future federal regulatory processes which may impact the permissible levels of microwave radiation emitted by the SPS Microwave Power Transmission (MPTS) were studied. An historical development of US occupational and public microwave standards includes an overview of Western and East European philosophies of environmental protection and neurophysiology which have led to the current widely differing maximum permissible exposure limits to microwaves. The possible convergence of microwave standards is characterized by a lowering of Western exposure levels while Eastern countries consider standard relaxation. A trend toward stricter controls on activities perceived as harmful to public health is under way as is interest in improving the federal regulatory process. Particularly relevant to SPS is the initiation of long-term, low-level microwave exposure programs. Coupled with new developments in instrumentation and dosimetry, the results from chronic exposure program and population exposure studies could be expected within the next five to ten years. Also discussed is the increasing public concern that rf energy is yet another hazardous environmental agent.

  13. Federal research policy 1988

    International Nuclear Information System (INIS)

    1988-01-01

    The report covers several separate parts dealing with the following: Orientation and perspectives of the Federal Government's research policy; resources available for science, research and development; fields of main interest in R and D work sponsored by the Government; research and technology policy of the Lands; international and national research and technology policy; organisations promoting and establishment doing research work in the FRG; statistics. The guidelines and principles of research policy are given: freedom of science and research; restraint from governmental influence within the meaning of the subsidiarity principle; positive attitude to scientific and technical progress; investigation of long-term perspectives and options; fostering joint responsibility of the Federal Government and the Lands; development of international cooperation. (orig./HSCH) [de

  14. From Soft Power to Economic Diplomacy? A Comparison of the Changing Rationales and Roles of the U. S. and Canadian Federal Governments in International Education. Research & Occasional Paper Series: CSHE.2.15

    Science.gov (United States)

    Trilokekar, Roopa Desai

    2015-01-01

    Through a historical and comparative analysis of international education policy development in Canada and the U.S., this paper will map the similarities and differences in the two countries. It will highlight the contributions and challenges of the government's involvement in international education (IE) in the two federal states and in…

  15. The European Federation of Organisations for Medical Physics Policy Statement No 14, The role of the Medical Physicist in the management of safety within the magnetic resonance imaging environment, EFOMP recommendations

    NARCIS (Netherlands)

    Hand, J.; Bosmans, H.; Caruana, C.; Keevil, S.; Norris, David Gordon; Padovani, R.; Speck, O.

    2013-01-01

    This European Federation of Organisations for Medical Physics (EFOMP) Policy Statement outlines the way in which a Safety Management System can be developed for MRI units. The Policy Statement can help eliminate or at least minimize accidents or incidents in the magnetic resonance environment and is

  16. Economic Energy Savings Potential in Federal Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Daryl R.; Dirks, James A.; Hunt, Diane M.

    2000-09-04

    The primary objective of this study was to estimate the current life-cycle cost-effective (i.e., economic) energy savings potential in Federal buildings and the corresponding capital investment required to achieve these savings, with Federal financing. Estimates were developed for major categories of energy efficiency measures such as building envelope, heating system, cooling system, and lighting. The analysis was based on conditions (building stock and characteristics, retrofit technologies, interest rates, energy prices, etc.) existing in the late 1990s. The potential impact of changes to any of these factors in the future was not considered.

  17. Federal Wildfire Activities. Current Strategy and Issues Needing Attention

    National Research Council Canada - National Science Library

    1999-01-01

    Concerned about the rising costs of preparing for and controlling wildfires, you asked us to provide information on how the Forest Service and the Bureau of Land Management manage their wildfire programs...

  18. Current activities on nuclear desalination in the Russian Federation

    International Nuclear Information System (INIS)

    Baranaev, Y.D.

    1996-01-01

    The goal of the RF desalination programme has been to develop small power floating nuclear seawater desalination complex based on KLT-40 reactor, originally developed for ship propulsion, as an energy source. Russia has sufficient fresh water resource rather evenly distributed over country territory (except for several specific conditions where sea or brackish water desalination is required for reliable long term potable water supply) and only limited internal deployment of this system is expected. Therefore, the development programme is mostly oriented to external market. Development of the floating nuclear desalination complex goes in parallel and is backed by the project of floating nuclear electricity and heat cogeneration plant using two KLT-40 reactors. This plant producing up to 70 MW(e) of electricity and up to 50 Gcal/of heat for district heating is now at the basic design stage and planned to be implemented around the year 2000 in Russia, at the Arctic Sea area

  19. Current Status of Federal Involvement in U.S. Aquaculture

    National Research Council Canada - National Science Library

    1995-01-01

    ...; little reached commercial markets. Although trout had been produced for food since the turn of the century, only with the advent of the catfish culture industry did commercial aquaculture gain visibility as a market force...

  20. 78 FR 27968 - Federal Management Regulation; Redesignations of Federal Buildings

    Science.gov (United States)

    2013-05-13

    ... Management Regulation; Redesignations of Federal Buildings AGENCY: Public Buildings Service (PBS), General... designation and redesignation of six Federal buildings. DATES: Expiration Date: This bulletin announcement expires July 30, 2013. The building designations and redesignations remains in effect until canceled or...

  1. 76 FR 76622 - Federal Management Regulation; Motor Vehicle Management

    Science.gov (United States)

    2011-12-08

    ...; Docket 2011-0011; Sequence 2] RIN 3090-AJ14 Federal Management Regulation; Motor Vehicle Management... Administration is amending the Federal Management Regulation (FMR) by revising current policy on the definitions... CONTACT: For clarification of content, contact Mr. James Vogelsinger, Director, Motor Vehicle Management...

  2. 76 FR 31545 - Federal Management Regulation; Motor Vehicle Management

    Science.gov (United States)

    2011-06-01

    ...; Sequence 1] RIN 3090-AJ14 Federal Management Regulation; Motor Vehicle Management AGENCY: Office of... Services Administration is proposing to amend the Federal Management Regulation (FMR) by revising current....C. 553(a)(2) because it applies to agency management. However, this proposed rule is being published...

  3. Block Grants and the New Federalism: Boon or Bane.

    Science.gov (United States)

    Williams, Ben

    1983-01-01

    The new federalism is explained, and reaction to block grants in California is described. Some alternatives to current proposals and programs, effects on research in the social sciences and human services, and conclusions about the prospects for the new federalism proposals are discussed. (MSE)

  4. Improving regulatory effectiveness in Federal/State siting actions: Federal/State regulatory permitting actions in selected nuclear power station licensing cases

    International Nuclear Information System (INIS)

    Baroff, J.

    1977-06-01

    The Federal/State regulatory permitting actions in 12 case histories of nuclear power station licensing in nine different states are documented. General observations regarding Federal/State siting roles in the siting process are included. Eleven of the case histories are illustrated with a logic network that gives the actions of the utilities in addition to the Federal/State permits

  5. Federating Distributed Storage For Clouds In ATLAS

    CERN Document Server

    Berghaus, Frank; The ATLAS collaboration

    2017-01-01

    Input data for applications that run in cloud computing centres can be stored at distant repositories, often with multiple copies of the popular data stored at many sites. Locating and retrieving the remote data can be challenging, and we believe that federating the storage can address this problem. A federation would locate the closest copy of the data on the basis of GeoIP information. Currently we are using the dynamic data federation Dynafed, a software solution developed by CERN IT. Dynafed supports several industry standards for connection protocols like Amazon’s S3, Microsoft’s Azure, as well as WebDAV and HTTP. Dynafed functions as an abstraction layer under which protocol-dependent authentication details are hidden from the user, requiring the user to only provide an X509 certificate.

  6. Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 2: Role of Growth Factors in Normal and Pathological Wound Healing: Therapeutic Potential and Methods of Delivery

    Science.gov (United States)

    Demidova-Rice, Tatiana N.; Hamblin, Michael R.; Herman, Ira M.

    2012-01-01

    This is the second of 2 articles that discuss the biology and pathophysiology of wound healing, reviewing the role that growth factors play in this process and describing the current methods for growth factor delivery into the wound bed. PMID:22820962

  7. Electronic Code of Federal Regulations

    Data.gov (United States)

    National Archives and Records Administration — The Electronic Code of Federal Regulations (e-CFR) is the codification of the general and permanent rules published in the Federal Register by the executive...

  8. The role of remote wind forcing in the subinertial current variability in the central and northern parts of the South Brazil Bight

    Science.gov (United States)

    Dottori, Marcelo; Castro, Belmiro Mendes

    2018-05-01

    Data analysis of continental shelf currents and coastal sea level, together with the application of a semi-analytical model, are used to estimate the importance of remote wind forcing on the subinertial variability of the current in the central and northern areas of the South Brazil Bight. Results from both the data analysis and from the semi-analytical model are robust in showing subinertial variability that propagates along-shelf leaving the coast to the left in accordance with theoretical studies of Continental Shelf Waves (CSW). Both the subinertial variability observed in along-shelf currents and sea level oscillations present different propagation speeds for the narrow northern part of the SBB ( 6-7 m/s) and the wide central SBB region ( 11 m/s), those estimates being in agreement with the modeled CSW propagation speed. On the inner and middle shelf, observed along-shelf subinertial currents show higher correlation coefficients with the winds located southward and earlier in time than with the local wind at the current meter mooring position and at the time of measurement. The inclusion of the remote (located southwestward) wind forcing improves the prediction of the subinertial currents when compared to the currents forced only by the local wind, since the along-shelf-modeled currents present correlation coefficients with observed along-shelf currents up to 20% higher on the inner and middle shelf when the remote wind is included. For most of the outer shelf, on the other hand, this is not observed since usually, the correlation between the currents and the synoptic winds is not statistically significant.

  9. Federalism and social justice: implications for social work.

    Science.gov (United States)

    Linhorst, Donald M

    2002-07-01

    Federalism is a system of government that divides power between two or more levels of government. During the current conservative political climate in the United States, power has shifted increasingly from the federal government to states, a move that has implications for the achievement of social justice. Consequently, it is now necessary for social workers to engage in political activity at the state and local levels, in addition to the federal level, to promote social justice. Implications for social work policy practice, research, and education for advancing social justice within the federal system of government are explored.

  10. 78 FR 45617 - Student Assistance General Provisions, Federal Perkins Loan Program, Federal Family Education...

    Science.gov (United States)

    2013-07-29

    ..., et al. Student Assistance General Provisions, Federal Perkins Loan Program, Federal Family Education... General Provisions, Federal Perkins Loan Program, Federal Family Education Loan Program, and William D... General Provisions, Federal Perkins Loan (Perkins Loan) Program, Federal Family Education Loan (FFEL...

  11. The Federal Air Pollution Program.

    Science.gov (United States)

    National Air Pollution Control Administration (DHEW), Washington, DC.

    Described is the Federal air pollution program as it was in 1967. The booklet is divided into these major topics: History of the Federal Program; Research; Assistance to State and Local Governments; Abatement and Prevention of Air Pollution; Control of Motor Vehicle Pollution; Information and Education; and Conclusion. Federal legislation has…

  12. The FY2011 Federal Budget

    Science.gov (United States)

    2010-08-04

    long been the largest source of federal revenues, followed by social insurance (payroll) taxes. Federal individual and corporate income tax revenues...915 billion (6.4% of GDP). Corporate income tax revenues fell from $304 billion in FY2008 to $138 billion in FY2009. Federal revenues from other

  13. Tax incentives in fiscal federalism

    DEFF Research Database (Denmark)

    Kelders, Christian; Köthenbürger, Marko

    2010-01-01

    Models of fiscal federalism rarely account for the efficiency implications of intergovernmental fiscal ties for federal tax policy. This paper shows that fiscal institutions such that federal tax deductibility, vertical revenue-sharing, and fiscal equalization (being common features of existing...

  14. Central Banking and the Crisis. A Comparison of the Federal Reserve and the European Central Bank Measures, and the ECB’s Changing Role in the EU Economic Governance System

    Directory of Open Access Journals (Sweden)

    Marcin Roman Czubala

    2016-06-01

    Full Text Available The European Central Bank (ECB has received a lot of criticism for its too little, too late performance to ease market pressures during the economic crisis. At the same time, the ECB and the Federal Reserve (FED have managed the new economic realities that have emerged in the international context differently. Despite the criticisms, the European Central Bank is the European Union institution that has assumed more control due to the new model of economic governance of the EU. Why did the Federal Reserve act so nimbly and quickly to calm the markets, while the ECB was so cautious in managing monetary policy? The aim of this paper is to perform a comparative analysis of the management of interest rates and other monetary policy measures undertaken by the Central Bank and the Federal Reserve during the economic crisis, as well as to understand the changes in the context of the ECB and the emergence of its authority within the European Union’s economic governance model since 2011. Thus, in order to carry out a scrupulous exposition, we will also limit the time frame of this study to the 2007-2014 period.

  15. The Role of Academic Motivation in High School Students’ Current and Lifetime Alcohol Consumption: Adopting a Self-Determination Theory Perspective*

    Science.gov (United States)

    Wormington, Stephanie V.; Anderson, Kristen G.; Corpus, Jennifer Henderlong

    2011-01-01

    Objective: The current study investigated the relationship between different types of academic motives—specifically, intrinsic motivation, introjected regulation, and external regulation—and high school students' current and lifetime alcohol consumption. Method: One thousand sixty-seven high school students completed measures of academic motivation, other school-related factors, and lifetime and current alcohol consumption. Results: Using structural equation modeling, different types of motivation and school-related factors were differentially related to student drinking. Specifically, intrinsic motivation was negatively related to lifetime and current alcohol consumption. External regulation, on the other hand, was positively associated with current drinking. Grade point average was the only school-related factor related to student alcohol use. Conclusions: These findings suggest that motivation is an important construct to consider in predicting students’ alcohol use, even when other more commonly studied educational variables are considered. In addition, it supports the adoption of a motivation framework that considers different types of motivation in understanding the relationship between academic motivation and alcohol use. Suggestions for incorporating the self-determination model of motivation into studies of alcohol and substance use, as well as potential impacts on intervention efforts, are discussed. In particular, it may be important to foster only certain types of motivation, rather than all types of academically-focused motives, in efforts to deter alcohol use. PMID:22051210

  16. The role of academic motivation in high school students' current and lifetime alcohol consumption: adopting a self-determination theory perspective.

    Science.gov (United States)

    Wormington, Stephanie V; Anderson, Kristen G; Corpus, Jennifer Henderlong

    2011-11-01

    The current study investigated the relationship between different types of academic motives-specifically, intrinsic motivation, introjected regulation, and external regulation-and high school students' current and lifetime alcohol consumption. One thousand sixty-seven high school students completed measures of academic motivation, other school-related factors, and lifetime and current alcohol consumption. Using structural equation modeling, different types of motivation and school-related factors were differentially related to student drinking. Specifically, intrinsic motivation was negatively related to lifetime and current alcohol consumption. External regulation, on the other hand, was positively associated with current drinking. Grade point average was the only school-related factor related to student alcohol use. These findings suggest that motivation is an important construct to consider in predicting students' alcohol use, even when other more commonly studied educational variables are considered. In addition, it supports the adoption of a motivation framework that considers different types of motivation in understanding the relationship between academic motivation and alcohol use. Suggestions for incorporating the self-determination model of motivation into studies of alcohol and substance use, as well as potential impacts on intervention efforts, are discussed. In particular, it may be important to foster only certain types of motivation, rather than all types of academically-focused motives, in efforts to deter alcohol use.

  17. Current role of MDCT in the diagnosis of coronary artery disease (2011). A clinical guideline of the Austrian Societies of Cardiology and Radiology

    International Nuclear Information System (INIS)

    Hergan, K.; Globits, S.; Loewe, C.

    2011-01-01

    The clinical guideline of the Austrian Societies for Cardiology and Radiology on the actual role of MDCT in the diagnosis of coronary artery diseases includes the following issues: CT calcium scoring; CT angiography (CTA) of the coronaries; actually recommended application of MDCR; generally inappropriate use of the technique for specific patients; radiation exposure; structural and organizational framework.

  18. Role of the lifetime of ring current particles on the solar wind-magnetosphere power transfer during the intense geomagnetic storm of 28 August 1978

    International Nuclear Information System (INIS)

    Gonzalez, W.D.; Gonzalez, A.L.C.; Lee, L.C.

    1990-01-01

    For the intense magnetic storms of 28 August 1978 it is shown that the power transfer from the solar wind to the magnetosphere is well represented by the expression obtained by Vasyliunas et al. (1982, Planet. Space Sci. 30, 359) from dimensional analysis, but this representation becomes improved when such an expression is modified by a factor due to an influence of the lifetime of ring current particles as suggested by Lee and Akasofu (1984, Planet. Space Sci. 32, 1423). During a steady state regime of the ring current evolution of this storm, our study suggests that the power transfer depends on the solar wind density, the transverse component of the IMF (Interplanetary magnetic field) (with respect to the Sun-Earth line) and also, explicitly, on the time constant for ring current energy decay, but not on the solar wind speed. (author)

  19. Federal Contributions to High-Income School Districts: The Use of Tax Deductions for Funding K-12 Education

    Science.gov (United States)

    Loeb, Susannna; Socias, Miguel

    2004-01-01

    The federal role in education finance is commonly seen as compensatory. The federal government gives large sums of money to low-income schools and school districts through programs such as Title 1. Yet, this view of federal aid is based solely on direct educational expenditures. The federal government and state governments also support schools…

  20. Role of Universities in Forming a Competence of Innovative Activity as an Essential Factor of Successful Realization of a Strategy of Innovative Development of the Russian Federation Until 2020

    Directory of Open Access Journals (Sweden)

    Nina M. Pestereva

    2012-10-01

    Full Text Available World economic crisis of 2008-2009 slowed down a development of Russian innovative system. Dedicated federal target programs have been worked out in order to restore after-crisis situation in the country and speed up a transfer to an innovative development. These programs envisage a range of activities aimed at forming competences of innovative activity, improvement of forms and scale of personnel training and re-training programs in engineering and scientific specializations, enhancing a range of educational programs in innovative entrepreneurship and technological management.The article describes mechanisms of attracting students, postgraduates and young researchers to solving tasks of Russia’s innovative development until 2020.