WorldWideScience

Sample records for curatively treated patients

  1. Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD

    Science.gov (United States)

    Tsai, Ming-Shao; Lai, Chia-Hsuan; Lee, Chuan-Pin; Yang, Yao-Hsu; Chen, Pau-Chung; Kang, Chung-Jan; Chang, Geng-He; Tsai, Yao-Te; Lu, Chang-Hsien; Chien, Chih-Yen; Young, Chi-Kuang; Fang, Ku-Hao; Liu, Chin-Jui; Yeh, Re-Ming A.

    2016-01-01

    Background Our study aimed to compare the outcomes of surgical treatment of tongue cancer patients in three different age groups. Methods From 2004 to 2013, we retrospectively analyzed the clinical data of 1,712 patients who were treated in the four institutions constituting the Chang Gung Memorial Hospitals (CGMH). We divided and studied the patients in three age groups: Group 1, younger (patients (≥75 years). Results Multivariate analyses determined the unfavorable, independent prognostic factors of overall survival to be male sex, older age, advanced stage, advanced T, N classifications, and surgery plus chemotherapy. No significant differences were found in adjusted hazard ratios (HR) of death in early-stage disease (stage I–II) among Group 1 (HR 1.0), Group 2 (HR 1.43, 95% confidence interval (CI) [0.87–2.34], p = 0.158), and Group 3 (HR 1.22, 95% CI [0.49–3.03], p = 0.664) patients. However, amongst advanced-stage patients (stage (III–IV)), Group 3 (HR 2.53, 95% CI [1.46–4.38], p  = 0.001) showed significantly worse survival than the other two groups after other variables were adjusted for. Fourteen out of 21 older old, advanced-staged patients finally died, and most of the mortalities were non-cancerogenic (9/14, 64.3%), and mostly occurred within one year (12/14, 85%) after cancer diagnosis. These non-cancer cause of death included underlying diseases in combination with infection, pneumonia, poor nutrition status, and trauma. Conclusions Our study showed that advanced T classification (T3–4), positive nodal metastasis (N1–3) and poorly differentiated tumor predicted poor survival for all patients. Outcome of early-stage patients (stage I–II) among three age groups were not significantly different. However, for advanced-stage patients (stage III–IV), the older old patients (≥75) had significantly worse survival than the other two patient groups. Therefore, for early-stage patients, age should not deny them to receive optimal

  2. Mortality in tongue cancer patients treated by curative surgery: a retrospective cohort study from CGRD

    Directory of Open Access Journals (Sweden)

    Ming-Shao Tsai

    2016-12-01

    Full Text Available Background Our study aimed to compare the outcomes of surgical treatment of tongue cancer patients in three different age groups. Methods From 2004 to 2013, we retrospectively analyzed the clinical data of 1,712 patients who were treated in the four institutions constituting the Chang Gung Memorial Hospitals (CGMH. We divided and studied the patients in three age groups: Group 1, younger (<65 years; Group 2, young old (65 to <75; and Group 3, older old patients (≥75 years. Results Multivariate analyses determined the unfavorable, independent prognostic factors of overall survival to be male sex, older age, advanced stage, advanced T, N classifications, and surgery plus chemotherapy. No significant differences were found in adjusted hazard ratios (HR of death in early-stage disease (stage I–II among Group 1 (HR 1.0, Group 2 (HR 1.43, 95% confidence interval (CI [0.87–2.34], p = 0.158, and Group 3 (HR 1.22, 95% CI [0.49–3.03], p = 0.664 patients. However, amongst advanced-stage patients (stage (III–IV, Group 3 (HR 2.53, 95% CI [1.46–4.38], p  = 0.001 showed significantly worse survival than the other two groups after other variables were adjusted for. Fourteen out of 21 older old, advanced-staged patients finally died, and most of the mortalities were non-cancerogenic (9/14, 64.3%, and mostly occurred within one year (12/14, 85% after cancer diagnosis. These non-cancer cause of death included underlying diseases in combination with infection, pneumonia, poor nutrition status, and trauma. Conclusions Our study showed that advanced T classification (T3–4, positive nodal metastasis (N1–3 and poorly differentiated tumor predicted poor survival for all patients. Outcome of early-stage patients (stage I–II among three age groups were not significantly different. However, for advanced-stage patients (stage III–IV, the older old patients (≥75 had significantly worse survival than the other two patient groups. Therefore, for early

  3. Patient-reported symptoms during radiotherapy. Clinically relevant symptom burden in patients treated with palliative and curative intent

    Energy Technology Data Exchange (ETDEWEB)

    Koerner, Philipp [Universitaetsklinikum Wuerzburg, Interdisziplinaeres Zentrum Palliativmedizin, Wuerzburg (Germany); Universitaetsklinikum Wuerzburg, Klinik und Poliklinik fuer Strahlentherapie, Wuerzburg (Germany); Ehrmann, Katja [Universitaetsklinikum Wuerzburg, Medizinische Psychologie und Psychotherapie, Medizinische Soziologie und Rehabilitationswissenschaften, Wuerzburg (Germany); Hartmannsgruber, Johann [Praxis Landshut, Kinderzahnheilkunde, Landshut (Germany); Metz, Michaela; Steigerwald, Sabrina; Flentje, Michael [Universitaetsklinikum Wuerzburg, Klinik und Poliklinik fuer Strahlentherapie, Wuerzburg (Germany); Oorschot, Birgitt van [Universitaetsklinikum Wuerzburg, Interdisziplinaeres Zentrum Palliativmedizin, Wuerzburg (Germany)

    2017-07-15

    The benefits of patient-reported symptom assessment combined with integrated palliative care are well documented. This study assessed the symptom burden of palliative and curative-intent radiation oncology patients. Prior to first consultation and at the end of RT, all adult cancer patients planned to receive fractionated percutaneous radiotherapy (RT) were asked to answer the Edmonton Symptom Assessment Scale (ESAS; nine symptoms from 0 = no symptoms to 10 = worst possible symptoms). Mean values were used for curative vs. palliative and pre-post comparisons, and the clinical relevance was evaluated (symptom values ≥ 4). Of 163 participating patients, 151 patients (90.9%) completed both surveys (116 curative and 35 palliative patients). Before beginning RT, 88.6% of palliative and 72.3% of curative patients showed at least one clinically relevant symptom. Curative patients most frequently named decreased general wellbeing (38.6%), followed by tiredness (35.0%), anxiety (32.4%), depression (30.0%), pain (26.3%), lack of appetite (23.5%), dyspnea (17.8%), drowsiness (8.0%) and nausea (6.1%). Palliative patients most frequently named decreased general wellbeing (62.8%), followed by pain (62.8%), tiredness (60.0%), lack of appetite (40.0%), anxiety (38.0%), depression (33.3%), dyspnea (28.5%), drowsiness (25.7%) and nausea (14.2%). At the end of RT, the proportion of curative and palliative patients with a clinically relevant symptom had increased significantly to 79.8 and 91.4%, respectively; whereas the proportion of patients reporting clinically relevant pain had decreased significantly (42.8 vs. 62.8%, respectively). Palliative patients had significantly increased tiredness. Curative patients reported significant increases in pain, tiredness, nausea, drowsiness, lack of appetite and restrictions in general wellbeing. Assessment of patient-reported symptoms was successfully realized in radiation oncology routine. Overall, both groups showed a high symptom burden

  4. The survival outcome and patterns of failure in node positive endometrial cancer patients treated with surgery and adjuvant radiotherapy with curative intent.

    Science.gov (United States)

    Rajasooriyar, Chrishanthi; Bernshaw, David; Kondalsamy-Chennakesavan, Srinivas; Mileshkin, Linda; Narayan, Kailash

    2014-10-01

    The purpose of this study was to evaluate the patterns of failure, overall survival (OS), disease-free survival (DFS) and factors influencing outcome in endometrial cancer patients who presented with metastatic lymph nodes and were treated with curative intent. One hundred and twenty-six patients treated between January 1996 to December 2008 with surgery and adjuvant radiotherapy were identified from our service's prospective database. Radiotherapy consisted of 45 Gy in 1.8 Gy fractions to the whole pelvis. The involved nodal sites were boosted to a total dose of 50.4 to 54 Gy. The 5-year OS rate was 61% and the 5-year DFS rate was 59%. Grade 3 endometrioid, serous, and clear cell histologies and involvement of upper para-aortic nodes had lower OS and DFS. The number of positive nodes did not influence survival. Among the histological groups, serous histology had the worst survival. Among the 54 patients relapsed, only three (6%) failed exclusively in the pelvis and the rest of the 94% failed in extrapelvic nodal or distant sites. Patients with grade 3 endometrioid, serous and clear cell histologies did not influence pelvic failure but had significant extrapelvic failures (pendometrial cancer patients fail at extrapelvic sites. The most important factors influencing survival and extrapelvic failure are grade 3 endometrioid, clear cell and serous histologies and involvement of upper para-aortic nodes.

  5. The effectiveness of a nurse-led intervention with the distress thermometer for patients treated with curative intent for breast cancer: design of a randomized controlled trial.

    Science.gov (United States)

    Ploos van Amstel, Floortje K; Prins, Judith B; van der Graaf, Winette T A; Peters, Marlies E W J; Ottevanger, Petronella B

    2016-07-25

    Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to assess the psychosocial consequences of the systematic use of the DT and its discussion by a nurse as compared to the usual care provided to outpatients who are treated for primary breast cancer is needed. The effectiveness of a nurse-led intervention with the DT will be tested in a non-blinded randomized controlled trial. Patients treated with curative intent for breast cancer will be recruited from the Radboud University Medical Center. The intervention consists of the DT together with discussion of the results with the patient by a trained oncology nurse added to the usual care. Patients will be randomly allocated (1:1) to either receive usual care or the usual care plus the intervention. Primary outcome measure is global quality of life measured with the EORTC QLQ-C30. The functional and symptom scales of the EORTC QLQ-C30 and BR23, Hospital Anxiety and Depression Scale, Impact of Event Scale, Illness Cognition Questionnaire and DT (baseline and final measurement only) will be used to measure secondary outcomes. Questionnaires are obtained in both arms at baseline, after completion of each type of cancer treatment modality and during follow up, with a three and six months' interval during the first and second year respectively. This study will be the first randomized controlled longitudinal study about the effectiveness of the DT as nurse led-intervention. In case of proven effectiveness, future implementation and standardization of use of the DT as part of routine care will be recommended. This study is registered at clinicaltrial.gov march 17, 2010 ( NCT01091584 ).

  6. Recurrence and Risk Factors for Relapse in Patients with Non-Small Cell Lung Cancer Treated by Surgery with Curative Intent.

    Science.gov (United States)

    Cruz, Cristiana; Afonso, Margarida; Oliveiros, Bárbara; Pêgo, Alice

    2017-01-01

    Surgery remains the potentially curative treatment for early-stage non-small cell lung cancer (NSCLC). Despite this, tumor recurrence is the most common cause of treatment failure after surgery. Data were collected retrospectively from clinical files of patients who underwent lung surgery for NSCLC from January 2008 to December 2012 in a University Hospital. Demographic data, tumor characteristics, type of surgery and recurrence were recorded. A comparison of the distribution of variables using adjustment tests was made. The study included 102 patients, 68.6% were male with a mean age of 63.7 ± 9.3 years old. The majority of tumors had a peripheral location (72.5%) and consisted of adenocarcinomas (61.8%). The most frequently performed surgery was lobectomy. Recurrence was noted in 43.1% of cases. Mean disease-free survival was 57.9 ± 3.8 months. Multifactorial analyses showed that stage IIIA, tumor located in other lobes than the right lower lobe and pleural invasion were independent predictors of recurrence. Our recurrence rate was similar to those in the international literature. As in other studies, we found a positive relation between the lymphatic permeation and pleural invasion and the risk of lung cancer recurrence. We consider that some characteristics of the tumor should be assessed to define alternative modalities of treatment and follow-up in order to predict and rapidly recognize the recurrence. © 2017 S. Karger AG, Basel.

  7. Research on short-term curative effect of VATS-assisted NUSS procedure in treating PE

    Institute of Scientific and Technical Information of China (English)

    Xin-Hui Rao; Yun-Han Liu; Jin-Song Liang; Gang Chen; Jian Li

    2015-01-01

    Objective: To study the short-term curative effect and the occurrence of postoperative complications of VATS-assisted NUSS procedure in treating congenital pectus excavatum (PE). Methods: 96 patients with congenital PE admitted into our hospital from March, 2008 to June, 2014 were chosen and divided into the study group and the control group randomly. Patients in the study group received VATS-assisted NUSS procedure while patients in the control group were treated with traditional NUSS procedure. Blood pressure, heart rate, operating time, blood loss, the length of hospital stay and ICU stay of all the patients during perioperative period were recorded. And a three-month follow-up was performed to record the short-term curative effects and the occurrence of postoperative complications.Results: The operating time, blood loss, length of hospital stay of the study group were remarkably less than those of the control group (P0.05). The excellent and good rate of curative effect and the total score of M-SSQ of the study group were significantly higher than those of the control group (P<0.05), while the occurrence of postoperative complications of the study group was significantly lower than that of the control group (P<0.05).Conclusions: With better short-term curative effect and less postoperative complications, VATS-assisted NUSS procedure could be regarded as a reliable and effective therapy for congenital PE.

  8. Prognostic significance of clusterin expression in advanced-stage cervical cancer treated with curative intended radiotherapy.

    Science.gov (United States)

    Watari, Hidemichi; Kinoshita, Rumiko; Han, Yimin; Wang, Lei; Hosaka, Masayoshi; Taguchi, Hiroshi; Tsuchiya, Kazuhiko; Tanaka, Shinya; Shirato, Hiroki; Sakuragi, Noriaki

    2012-03-01

    Overexpression of clusterin (CLU), an antiapoptotic molecule, has been reported to induce resistance to radiotherapy (RT) in a variety of cancer cell types. The aim of this study was to evaluate the significance of CLU expression to predict survival of patients with advanced-stage cervical cancer who received curative intended RT. Biopsy tissue specimens of advanced-stage cervical cancer before curative intended RT were obtained from 34 patients who were treated at Hokkaido University Hospital between 1998 and 2008 and whose complete medical records were available. The expression of CLU protein was analyzed by immunohistochemistry. Findings were evaluated in relation to several clinicopathological factors. Survival analyses were performed using the Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by multivariate Cox regression analysis. Clusterin protein was mainly present in the cytoplasm of cervical cancer cells. The expression of CLU protein in cervical cancer tissues before curative intended RT was not significantly related to any clinicopathological factors analyzed, including age, clinical stage, histologic type, and response to RT. Univariate analysis on prognostic factors showed that histologic type (P = 0.001), and CLU expression (P = 0.02) were related to survival. Multivariate analysis revealed that both histologic type (P = 0.002), and CLU expression (P = 0.02) were independent prognostic factors for overall survival. We conclude that CLU could be a new molecular marker to predict overall survival of patients with advanced-stage cervical cancer treated with curative intended RT.

  9. Clinical Outcomes of Resectable Esophageal Cancer with Supraclavicular Lymph Node Metastases Treated with Curative Intent.

    Science.gov (United States)

    Honma, Yoshitaka; Hokamura, Nobukazu; Nagashima, Kengo; Sudo, Kazuki; Shoji, Hirokazu; Iwasa, Satoru; Takashima, Atsuo; Kato, Ken; Hamaguchi, Tetsuya; Boku, Narikazu; Umezawa, Rei; Ito, Yoshinori; Itami, Jun; Koyanagi, Kazuo; Igaki, Hiroyasu; Tachimori, Yuji

    2017-07-01

    In the seventh edition of the Union for International Cancer Control (UICC) TNM classification, supraclavicular lymph node (SCLN) in regard to thoracic esophageal cancer (EC) is regarded as a distant organ, therefore, if resectable, SCLN metastasis is considered a candidate for systemic chemotherapy. The purpose of this study was to clarify the survival outcome in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated with curative intent. Clinical outcomes in patients with resectable thoracic EC with SCLN metastases (M1LYM) treated by esophagectomy or definitive chemoradiotherapy (dCRT) were retrospectively analyzed. A total of 102 patients were divided in three groups: Surgery with perioperative therapy, n=45; surgery alone, n=19; and dCRT, n=38. Overall, median progression-free survival and median survival time were 9.3 and 26.7 months, respectively. The median survival time was 27.5 months in the group treated with surgery with perioperative treatment, 50.6 months in those treated with surgery alone, and 22 months in the dCRT group. No significant survival difference was seen among the three groups. Over 30% of patients with resectable M1LYM treated with curative intent achieved long-term survival. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  10. Prognostic significance of lymphovascular space invasion and nodal involvement in intermediate- and high-risk endometrial cancer patients treated with curative intent using surgery and adjuvant radiotherapy.

    Science.gov (United States)

    Narayan, Kailash; Khaw, Pearly; Bernshaw, David; Mileshkin, Linda; Kondalsamy-Chennakesavan, Srinivas

    2012-02-01

    The aim of this study was to assess whether lymphovascular space invasion (LVSI) and nodal status provide adequate prognostic information in comparison with the entire set of traditional prognostic factors in intermediate- and high-risk endometrial cancer patients treated and staged with primary surgery and adjuvant radiotherapy. Three hundred twenty-four previously untreated high-intermediate- and high-risk endometrial cancer patients with FIGO (International Federation of Gynecology and Obstetrics) stage I to IIIC; endometrioid, serous, or clear cell histology; diagnosed between November 1995 and December 2006; who presented to Peter MacCallum Cancer Centre for adjuvant radiotherapy were included in these analyses. All traditionally recognized prognostic factors and newly created 4 pairs of combination of LVSI and nodal status were studied with respect to survival and patterns of failure. The median follow-up time was 4.8 years. Five-year failure-free survival for all patients according to FIGO stage I, II, and III were 87.4%, 89.0%, and 62.4 %, respectively. In multivariable analysis for relapse, positive LVSI had a hazard ratio of 4.9 (P = 0.000), which increased to 8.8 (P = 0.004) in the presence of positive nodes. For overall survival, only LVSI was significant, with a hazard ratio of 3.02 (P = 0.003). In particular, in the presence of LVSI and nodes, histological type, grade, and myometrial invasion were not significant prognosticators for relapse or overall survival. This model enables the separation of good prognosis patients even among poorly differentiated endometrioid, serous, and clear cell carcinoma patients and can be used in simplifying the staging of endometrial cancer and for selecting patients for high-risk endometrial cancer studies.

  11. Patient surveillance after curative-intent surgery for rectal cancer.

    Science.gov (United States)

    Johnson, Frank E; Longo, Walter E; Ode, Kenichi; Shariff, Umar S; Papettas, Trifonas; McGarry, Alaine E; Gammon, Steven R; Lee, Paul A; Audisio, Riccardo A; Grossmann, Erik M; Virgo, Katherine S

    2005-09-01

    The follow-up of patients with rectal cancer after potentially curative resection has significant financial and clinical implications for patients and society. The ideal regimen for monitoring patients is unknown. We evaluated the self-reported practice patterns of a large, diverse group of experts. There is little information available describing the actual practice of clinicians who perform potentially curative surgery on rectal cancer patients and follow them after recovery. The 1795 members of the American Society of Colon and Rectal Surgeons were asked, via a detailed questionnaire, how often they request 14 discrete follow-up modalities in their patients treated for cure with TNM stage I, II, or III rectal cancer over the first five post-treatment years. 566/1782 (32%) responded and 347 of the respondents (61%) provided evaluable data. Members of the American Society of Colon and Rectal Surgeons typically follow their own patients postoperatively rather than sending them back to their referral source. Office visit and serum CEA level are the most frequently requested items for each of the first five postoperative years. Endoscopy and imaging tests are also used regularly. Considerable variation exists among these highly experienced, highly credentialed experts. The surveillance strategies reported here rely most heavily on relatively simple and inexpensive tests. Endoscopy is employed frequently; imaging tests are employed less often. The observed variation in the intensity of postoperative monitoring is of concern.

  12. The effectiveness of a nurse-led intervention with the distress thermometer for patients treated with curative intent for breast cancer: design of a randomized controlled trial

    NARCIS (Netherlands)

    Amstel, F.K. Ploos van; Prins, J.B.; Graaf, W.T.A. van der; Peters, M.E.W.J.; Ottevanger, P.B.

    2016-01-01

    BACKGROUND: Distress in patients with cancer influences their quality of life. Worldwide, screening on distress with the Distress Thermometer (DT) in patients with cancer is recommended. However, the effects of the use of the DT on the psychosocial wellbeing of the patient are unknown. A study to

  13. Curative ef ect observation of 37 functional constipation patients treated with biofeedback therapy%生物反馈治疗功能性便秘37例疗效观察

    Institute of Scientific and Technical Information of China (English)

    金学林

    2014-01-01

    目的:探讨生物反馈治疗功能性便秘的临床疗效。方法对我院2012年11月-2014年5月进行生物反馈治疗的37例功能性便秘病人回顾分析。结果生物反馈治疗后患者便秘症状评分显著降低,有效率为81.08%。结论生物反馈治疗对功能性便秘治疗安全有效。%Objective We aim to study the clinical curative ef ect of biofeedback therapy for functional constipation.Methods Clinic data of 37 functional constipation patients were evalua-ted.They were treated with biofeedback therapy in our hospital during November 2012 to May 2014.Results After biofeedback therapy,functional constipation symptom scores of patients de-creased significantly,with ef ective rate of 81.08%.Conclusions Biofeedback therapy for the treatment of functional constipation is safe and ef ective.

  14. Modern oncologic and operative outcomes for oesophageal cancer treated with curative intent.

    LENUS (Irish Health Repository)

    Reynolds, J V

    2011-09-01

    The curative approach to oesophageal cancer carries significant risks and a cure is achieved in approximately 20 per cent. There has been a recent trend internationally to observe improved operative and oncological outcomes. This report audits modern outcomes from a high volume centre with a prospective database for the period 2004-08. 603 patients were referred and 310 (52%) were treated with curative intent. Adenocarcinoma represented 68% of the cohort, squamous cell cancer 30%. Of the 310 cases, 227 (73%) underwent surgery, 105 (46%) underwent surgery alone, and 122 (54%) had chemotherapy or combination chemotherapy and radiation therapy. The postoperative mortality rate was 1.7%. The median and 5-year survival of the 310 patients based on intention to treat was 36 months and 36%, respectively, and of the 181 patients undergoing R0 resection, 52 months and 42%, respectively. An in-hospital postoperative mortality rate of less than 2 per cent, and 5-year survival of between 35 and 42% is consistent with benchmarks from international series.

  15. Curative effect observation of TCM in treating 106 patients with menopausal syndrome%中医治疗更年期综合征106例疗效观察

    Institute of Scientific and Technical Information of China (English)

    李玉萍

    2016-01-01

    目的:观察中医治疗更年期综合征的临床疗效。方法:应用中医辨证方法分5型,治疗更年期综合征。结果:总有效率为94.3%。结论:中医辨证治疗更年期综合征,疗效满意。%Objective: To observe the clinical curative effect of TCM in treating menopausal syndrome. Method:Traditional Chinese medicine treatment based on syndrome differentiation was adopted and herein 5 types of syndrome were identified. Result:The overall effective rate was 94.3%. Conclusion:Treating menopausal syndrome by traditional Chinese medicine based on syndrome differentiation had a satisfactory curative effect.

  16. Pattern of failure in 5001 patients treated for glottic squamous cell carcinoma with curative intent - A population based study from the DAHANCA group

    DEFF Research Database (Denmark)

    Lyhne, Nina Munk; Johansen, Jørgen; Kristensen, Claus A;

    2016-01-01

    were lost to follow-up. In total 1511 failures were observed; of these 93%, 11% and 5% included T site, N site, and M site, respectively. For patients diagnosed in the 70s and the 00s, respectively, the five-year incidences were: local failure (32% vs 19%), loco-regional failure (34% vs 21...

  17. Epidermoid carcinomas of the anal canal treated with definitive radiation therapy in a series of 305 patients; Carcinomes epidermoides du canal anal traites par irradiation a visee curative: a propos de 305 patients

    Energy Technology Data Exchange (ETDEWEB)

    Deniaud-Alexandre, E.; Touboul, E.; Huang, R.; Qu, S.H.; Pene, F.; Schlienger, M. [Hopital Tenon, Service d' Oncologie-Radiotherapie, 75 - Paris (France); Tiret, E.; Parc, R. [Hopital Saint-Antoine, Service de Chirurgie Digestive, 75 - Paris (France); Sezeur, A. [Hopital des Diaconesses, Service de Chirurgie Generale, 75 - Paris (France); Houry, S. [Hopital Tenon AP-HP, Service de Chirurgie Digestive, 75 - Paris (France); Gallot, D. [Groupe Hospitalier Bichat-Claude-Bernard, Service de Chirurgie Generale et Digestive B, 75 - Paris (France)

    2003-08-01

    Purpose. - To identify prognostic factors and treatment toxicity in a series of epidermoid cancers of the anal canal without evident metastasis. Patients and methods. - Between June 1972 and January 1997, 305 patients (pts) were treated with curative-intent radiation therapy (RT). The T-stages according to the 1987 UICC classification were: 26 T1, 141 T2, 104 T3, and 34 T4. There were 49 pts with nodal involvement at presentation. Pretreatment anal function scoring according to our in-house system was: 22 scored 0, 182 scored 1, 74 scored 2, 7 scored 3. 11 scored 4, and 9 not available pts. The treatment started with external beam RT (EBRT) in 303 pts (median dose: 45 Gy). After a rest period of 4 to 6 weeks, a boost of 20 Gy was delivered by EBRT in 279 pts and by interstitial {sup 192}Ir brachytherapy (Bcy) in 17 pts. Seven pts received only one course of EBRT (mean dose: 49.5 Gy) and 2 pts were treated with interstitial {sup 192}Ir Bcy alone (55 and 60 Gy, respectively). concomitant chemotherapy (5-fluoro-uracil and either mitomycin C or cisplatin) was delivered to 19 pts. Mean follow-up was 103 months. Results. - At the end of RT local tumor clinical complete response (cCR) rate was 80%. Out of 61 non responders or local progressive tumors 27 (44%) were salvaged with abdomino-perineal resection (APR). The rate of local tumor relapse (LR) was 12%. Out of 37 LTR, 20 (54%) were salvaged with APR and one with interstitial {sup 192}Ir Bcy. The overall local tumor control (LC) rate with or without salvage local treatment was 84%. LC rate with a good anal function scoring (score 0 and 1) was 56.5%0. Among 181/186 available pts who preserved their anus, 94% had a good anal function scoring. For a subgroup of 15 pts with length tumor <2 cm-N0, the LC rate after the end of RT was 100% the LC rate with or without local salvage treatment was 100%, and among 13 available pts who preserved their anus, the anal function scoring was good in 12 pts (92%). The 10-years disease

  18. The curative effects of LPN combined LCA in treating with middle and advanced renal cancer.

    Science.gov (United States)

    Qiu, M-J; Tian, H; Pang, C; Yang, Z-J; Li, C-Q; Xu, L

    2016-01-01

    To discuss the curative effects of laparoscopy partial nephrectomy (LPN) combined with laparoscopy cryoablation (LCA) in treating renal cancer. A total of 58 patients that were diagnosed with phase III-IV renal cancer in the Hospital from February 2013 to October 2014 were enrolled in this study. After obtaining the approval of Ethics Committee of the Hospital as well as the informed consent of the patients and their relatives, the patients were randomly divide into two groups: control group consisted of 24 patients, who were treated with LPN + chemo radiotherapy and the observation group consisted of 34 patients, who were treated with LPN in combination of LCA + chemo radiotherapy. The rate of successful operation was significantly higher in the observation group than in control group and the prevalence of per procedural complications in observation group was significantly lower than that of control group, and these differences had statistical significance (p LCA therapy was quite effective in treating with middle and advanced renal cancer. Compared with pure LPN therapy, LPN combined LCA therapy could significantly improve the surgical effects, retain the functions of the renal unit and improve the patients' prognosis.

  19. Prognostic factors of T4 gastric cancer patients undergoing potentially curative resection

    Institute of Scientific and Technical Information of China (English)

    Naoto Fukuda; Yasuyuki Sugiyama; Joji Wada

    2011-01-01

    AIM: To investigate the prognostic factors of T4 gas-tric cancer patients without distant metastasis who could undergo potentially curative resection. METHODS: We retrospectively analyzed the clinical data of 71 consecutive patients diagnosed with T4 gas-tric cancer and who underwent curative gastrectomy at our institutions. The clinicopathological factors that could be associated with overall survival were evalu-ated. The cumulative survival was determined by the Kaplan-Meier method, and univariate comparisons be-tween the groups were performed using the log-rank test. Multivariate analysis was performed using the Cox proportional hazard model and a step-wise procedure.RESULTS: The study patients comprised 53 men (74.6%) and 18 women (25.4%) aged 39-89 years (mean, 68.9 years). Nineteen patients (26.8%) had postoperative morbidity: pancreatic fistula developed in 6 patients (8.5%) and was the most frequent compli-cation, followed by anastomosis stricture in 5 patients (7.0%). During the follow-up period, 28 patients (39.4%) died because of gastric cancer recurrence, and 3 (4.2%) died because of another disease or accident. For all patients, the estimated overall survival was 34.1% at 5 years. Univariate analyses identified the following statis-tically significant prognostic factors in T4 gastric cancer patients who underwent potentially curative resection: peritoneal washing cytology (P < 0.01), number of met-astatic lymph nodes (P < 0.05), and venous invasion (P < 0.05). In multivariate analyses, only peritoneal wash-ing cytology was identified as an independent prognos-tic factor (HR = 3.62, 95% CI = 1.37-9.57) for long-term survival. CONCLUSION: Positive peritoneal washing cytology was the only independent poor prognostic factor for T4 gastric cancer patients who could be treated with potentially curative resection.

  20. Perceptual learning for treating amblyopia in children based on activation of visual signal pathway Relationship of curative effects and time

    Institute of Scientific and Technical Information of China (English)

    Weimin Liu; Jiang Shen; Jianzhong Huang; Yan Luo; Hongting Liu

    2008-01-01

    cortical neurons. According to results of visual function tests, individualized treatment was adopted for each amblyopia patient using perceptual learning system. One course of treatment lasted one month, and treatment was performed twice every day with two training procedures (each training procedure lasted for ten minutes). There was a ten-minute time interval between the two training procedures. The training treatment was performed in a quiet and dark environment. Visual acuity and recovery of visual function were tested every month. Original training procedure was continued or adjusted according to the results of visual function.MAIN OUTCOME MEASURES: Visual function change; relationship of curative effects and curative time. RESULTS: A total of 125 amblyopia children were included in the final analysis. The total efficiency of perceptual learning for treating amblyopia in children was 75.2%. Visual acuity began to greatly increase 3 months after treatment (P < 0.05). Visual acuity was best corrected from 0.60 ± 0.23 before treatment to 0.86 ± 0.26 after treatment (P < 0.05). The mean time to reach improved levels with curative effects was (2.82 ± 1.30) months, and to reach a basically cured level was (2.87 ± 1.40) months. Percentage of improved visual acuity was the highest [98% (39/40)] in children that received 3 months of treatment and the lowest [55% (31/56)] in children that received 1 month of treatment (P < 0.05). The percentage of basically cured levels with curative effects increased with length of learning time and was the greatest in children that received 4 months of treatment [67% (31/46), P < 0.05]. CONCLUSION: Perceptual learning rapidly and remarkably improves visual function of amblyopia children; however, the curative effects are first apparent two and three months after intervention.

  1. Analysis of curative effect of edaravone combined with seven Ye Zao glycosides sodium on treating patients with cerebral hemorrhage%依达拉奉联合七叶皂苷钠治疗脑出血的疗效观察

    Institute of Scientific and Technical Information of China (English)

    韩桐师; 王丹辉; 孙岩; 谢满红; 周平

    2014-01-01

    Objective To investigate the clinical curative effect of edaravone combined with seven Ye Zao glycosides sodi-um on treating patients with cerebral hemorrhage. Methods 60 patients with cerebral hemorrhage from February 2012 to De-cember 2012 in our hospital were randomly divided into the observation group (n=30 ,treated with the conventional treatment ) and the control group (n=30 ,treated with the edaravone combined with seven Ye Zao glycosides sodium ). The curative effect of two groups were compared. Results The total effective rate was 93.3% (in the observation group) and 76.7% (in the con-trol group);The NIHSS score ,edema area and hematoma volume of observation group were lower than these of control group , which had a significantly statistical difference (P<0.05). Conclusion The edaravone combined with seven Ye Zao glycosides sodium has a better curative effect on treating patients with cerebral hemorrhage ,which is worthy of clinical application.%目的:探讨依达拉奉联合七叶皂苷钠治疗脑出血的临床疗效。方法60例脑出血患者采用随机对照方法分为观察组和对照组各30例。对照组给予常规对症支持治疗,观察组在此基础上应用依达拉奉联合七叶皂苷钠治疗,比较2组临床疗效。结果观察组总有效率93.3%,对照组76.7%,观察组显著高于对照组,差异有统计学意义( P<0.05);观察组NIHSS评分、水肿面积及血肿体积均显著少于对照组,差异有统计学意义(P<0.05)。结论依达拉奉联合七叶皂苷钠治疗脑出血疗效显著,可有效改善患者临床症状,促进神经功能恢复,值得临床应用和推广。

  2. OBSERVATION OF CLINICAL CURATIVE EFFECT OF CEREBRAL FUNCTIONAL HEALTH INSTRUMENT FOR TREATING INSOMNIA JINZHOU KANGNING HOSPITAL

    Institute of Scientific and Technical Information of China (English)

    Shi Jinzhong

    2000-01-01

    Purpose 1t is researening to curative effect for treating the msomnia by non-medicine therapy Methods: The cases of 99 patments in acecrdance with the diagnosis standard CCMD-Ⅱ- R are applied with model BW-308 cerebral functional health instrment to be taken once every day , 15 minutes every time . A course of treatment has 15 tunes. Results The effective rate is 75 7 percent After treating the average grade of oneself meter of the sleep-disorder is distinet fall The average grade it=16 6. P<0.01) of SAS and SDS meter is distinet fall (The value t respectively is 6.4 and 7.8, p<0.01) is also distict difierent Conclusion The cerebral functional health instrument is really a efectivc supplementary instrument for treating the insomma It is specific worth to research to be used for treaung the neuropathy

  3. [Comparative study on curative effects of stroke treated with acupuncture by NIRS].

    Science.gov (United States)

    Li, Hong; Hou, Zhong-wei; Bai, Yu-lan; Gu, Shi-zhe

    2011-11-01

    To compare the intracephalic imaging differences of stroke treated with combined therapy of scalp and body acupuncture and body acupuncture only, in order to apply the image basis for the differences of clinical curative effects. Twenty cases of stroke were randomized into a body acupuncture group (group A) and a scalp and body acupuncture group (group B), ten cases in each group respectively. In group A, body acupuncture was applied simply, and different acupoints were selected according to the symptoms: Shousanli (LI 10), Jianliao (TE 14), Huantiao (GB 30) and Jiaji (EX-B 2) etc. were selected for hemiplegia, Fengchi (GB 20), Xiaguan (ST 7) and Quanliao (SI 18) etc. were for facial paralysis, Fengfu (GV 16) and Lianquan (CV 23) etc. were for aphasia. In group B, combined therapy were applied, the body acupoints selection was same as above; for scalp acupoints, corresponding motor area, sensory area and foot motor sensory area were selected. Instant changes of local cerebral blood flow before and after treatment were examined and evaluated by NIRS and the curative effects of both groups were evaluated. The total therapeutic effective rate was 90.0% (9/10) and the basically cured rate was 30.0% (3/10) in group A; and 100.0% (10/10) and 50.0% (5/10) respectively in group B, indicating that the clinical curative effect in group B was superior to that in group A at 20, 30 min of acupuncture treatment (P acupuncture treatment (all P Acupuncture can significantly increase blood flow and oxygen saturation in brain cortex, and the effect with combined therapy of scalp and body acupuncture is superior to that with body acupuncture.

  4. Pixel 2940激光治疗痤疮萎缩性瘢痕的疗效及对患者心理的影响%Curative observation and the influence on the mental status of the patients with acne scars treated with pixel2940 laser

    Institute of Scientific and Technical Information of China (English)

    严月华; 徐丽; 卢忠; 刘琴; 肖桂凤

    2013-01-01

    目的:了解痤疮凹陷性瘢痕患者的心理健康状况,观察Pixel 2940激光治疗痤疮凹陷性瘢痕的疗效及对患者心理健康的影响.方法:2010年10月~ 2012年8月,笔者科室采用Pixel 2940激光治疗痤疮瘢痕患者39例,并在治疗前和治疗结束后1月用Cardiff痤疮心理评估量表评估患者心理状况.结果:Pixel 2940激光治疗痤疮凹陷性瘢痕有效率达94.9%,副反应少而轻;痤疮影响了患者的心理健康,患者常常感到焦虑、愤怒和自信心下降等,但治疗后心理明显好转.结论:用Pixel 2940激光治疗痤疮凹陷性瘢痕疗效稳定、副反应少,可改善患者心理健康状况.%Objective To investigate the mental status of the patients with acne scars, and to observe the curative effect and the influence on mental health of the patients with acne scars treated with Pixel laser and. Methods From October 2010 to August 2012, 39 patients with acne scars were treated by Pixel 2940 laser, and before the treatment and 1 month after the treatment, the mental status were investigated by using the Cardiff Acne Psychological Assessment Questionaire. Results Of 39 cases with acne scars, the total effective rate was 94.9%, the adverse effective was little and light. Acne scars affects the mental health of some patients, the main manifestations are anxiety, anger and decreased self-confident, but after the treatment, the mental status of the patients were significantly improved. Conclusion The treatment of acne scars with Pixel 2940 laser has steady curative effect and little adverse effect, and can improve the psychological health status of the patients.

  5. Prognostic Factors for Patients after Curative Resection for Proximal Gastric Cancer

    Institute of Scientific and Technical Information of China (English)

    赵东晖; 徐惠绵; 李凯; 孙哲

    2010-01-01

    The factors influencing the long-term survival of patients with proximal gastric cancer (PGC) after curative resection were investigated. Data from 171 patients who underwent curative resection for PGC were retrospectively analyzed. The patients were grouped according to the clinicopathological factors and operative procedures. The tumor depth (T stage) and lymph node metastasis (pN stage) were graded according to the fifth edition of TNM Staging System published by UICC in 1997. The metastatic lymph node r...

  6. Long-Term Outcomes and Patterns of Relapse of Early-Stage Extranodal Marginal Zone Lymphoma Treated With Radiation Therapy With Curative Intent

    Energy Technology Data Exchange (ETDEWEB)

    Teckie, Sewit; Qi, Shunan; Lovie, Shona [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Navarrett, Scott [Weill Cornell Medical College, New York, New York (United States); Hsu, Meier [Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Noy, Ariela; Portlock, Carol [Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York (United States); Yahalom, Joachim, E-mail: yahalomj@mskcc.org [Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York (United States)

    2015-05-01

    Purpose: To report the long-term outcome and patterns of relapse of a large cohort of marginal zone lymphoma (MZL) patients treated with curative-intent radiation therapy (RT) alone. Patients and Methods: We reviewed the charts of 490 consecutive patients with stage IE or IIE MZL referred between 1992 and 2012 to our institution. Of those, 244 patients (50%) were treated with RT alone. Pathology was confirmed by hematopathologists at our institution. Patient and disease factors were analyzed for association with relapse-free survival (RFS) and overall survival (OS). Results: Median age of the cohort was 59 years, and median follow-up was 5.2 years. Ann Arbor stage was IE in 92%. Most common disease sites were stomach (50%), orbit (18%), non-thyroid head-and-neck (8%), skin (8%), and breast (5%). Median RT dose was 30 Gy. Five-year OS and RFS were 92% and 74%, respectively. Cumulative incidence of disease-specific death was just 1.1% by 5 years. Sixty patients (24%) developed relapse of disease; 10 were in the RT field. Crude rate of transformation to pathologically confirmed large-cell lymphoma was 1.6%. On multivariable analysis, primary disease site (P=.007) was independently associated with RFS, along with age (P=.04), presence of B-symptoms (P=.02), and International Prognostic Index risk group (P=.03). All disease sites except for head-and-neck had worse RFS relative to stomach. Conclusion: Overall and cause-specific survival are high in early-stage extra-nodal MZL treated with curative RT alone. In this large cohort of 244 patients, most patients did not experience relapse of MZL after curative RT; when relapses did occur, the majority were in distant sites. Stomach cases were less likely to relapse than other anatomic sites. Transformation to large-cell lymphoma was rare.

  7. 苗药鹿角壮骨胶囊辅助治疗骨质疏松性椎体压缩骨折46例临床观察%Study on Curative Effect Miao medicine Antler Bone Improvement Capsule Treating Patients with Osteoporotic Vertebral Compression Fracture

    Institute of Scientific and Technical Information of China (English)

    唐广应; 陆永刚; 赵久敏; 张凯

    2016-01-01

    目的:观察苗药鹿角壮骨胶囊辅助治疗骨质疏松性椎体压缩骨折(OVCF)的临床疗效。方法:选取86例 OVCF 患者为研究对象,随机分为对照组40例和治疗组46例。对照组采用 PVP 手术治疗后口服碳酸钙 D3和阿法骨化醇治疗,治疗组在对照组基础上加用苗药鹿角壮骨胶囊治疗,比较观察两组的疗效、骨 CT 值、骨密度值、再次骨折发生情况。结果:治疗组优良率93.47%高于对照组的80.00%,两组优良率比较,差异具有统计学意义(P <0.05);疗程结束后及结束后12个月随访,治疗组 CT 值和骨密度均高于对照组(P<0.05),而再骨折发生率低于对照组(P <0.05)。结论:苗药鹿角壮骨胶囊胶囊辅助治疗骨质疏松性椎体压缩骨折疗效好,且再骨折发生率较低,能明显改善患者的生活质量。%Objective the curative effect Miao medicine antler bone improvement capsule treating patients with OVCF.Method By randomized control test method to randomly divide 86 patients with OVCF control group 40 patients and treatment group 46 patients, the control group was treated by PVP operation,then given calcium carbonate D3 tablets and alfacalcidol capsules,The treatment group was based on basic medication group to plus Lujiao -zhuanggu capsule.Observe groups of patients'CT value,bone density,as well as observe the incidence of re -fracture.Results Compare the clinical effect of two groups,the treatment group with excellent and good rate of 93.47%;The control group with excellent and good rate of 80.00%;Compare the excellent and good rate of two groups,the difference has statistical significance (P <0.05).After and the end of treatment 12 months,the improvement of CT value and bone density of treatment group is significantly higher than what of control group (P <0.05),however,the incidence of re -frac-ture is significantly lower than what of control group (P <0.05).Conclusion The

  8. ANALYSIS OF THE CURATIVE EFFECT OF URL AND ESWL ON URETERAL CALCULI TREAT OF THE OLD PATIENTS%URL与ESWL治疗老年输尿管结石的疗效分析

    Institute of Scientific and Technical Information of China (English)

    刘岩山

    2012-01-01

    [目的]探讨输尿管镜下气压弹道碎石(URL)和体外冲击波碎石(ESWL)治疗老年输尿管结石的疗效.[方法]回顾性分析2007年1月~2010年12月在某院分别采用URL与ESWL治疗的输尿管结石老年患者临床资料.[结果] URL组总成功率和中下段结石成功率明显高于ESWL组,差异有统计学意义(均P<0.01);上段结石成功率低于ESWL组,差异有统计学意义(P<0.05).URL组发热和肾绞痛均明显少于ESWL组,差异有统计学意义(均P<0.01);恶心呕吐、肉眼血尿和输尿管穿孔差异均无统计学意义(均P> 0.05).[结论]URL在微创性上更有优势,ESWL应作为老年输尿管上段结石的首选,URL应作为老年输尿管中下段结石的首选.%{Objective] To investigate the therapeutic effect of Ureteroscopic Iithotripsy (URL) and Extracorporeal Shock Wave Iithotripsy {ESWL) on the ureterai calculi in the old patients. [Methods] A retrospective analysis was carried out for the therapeutic effect of URL and ESWL treatment on ureterai calculi of elderly patients from January 2007 years to De* 0.0S). [Conclusion] Minimally invasive URL treatment has more advantages. ESWL should be the Crest choice with upper ureleral calculi, and URL should be the first choice for lower ureterai cal-cuili for the old patients.

  9. Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection.

    Science.gov (United States)

    Kuroda, Daisuke; Sawayama, Hiroshi; Kurashige, Junji; Iwatsuki, Masaaki; Eto, Tsugio; Tokunaga, Ryuma; Kitano, Yuki; Yamamura, Kensuke; Ouchi, Mayuko; Nakamura, Kenichi; Baba, Yoshifumi; Sakamoto, Yasuo; Yamashita, Yoichi; Yoshida, Naoya; Chikamoto, Akira; Baba, Hideo

    2017-06-27

    Controlling Nutritional Status (CONUT), as calculated from serum albumin, total cholesterol concentration, and total lymphocyte count, was previously shown to be useful for nutritional assessment. The current study investigated the potential use of CONUT as a prognostic marker in gastric cancer patients after curative resection. Preoperative CONUT was retrospectively calculated in 416 gastric cancer patients who underwent curative resection at Kumamoto University Hospital from 2005 to 2014. The patients were divided into two groups: CONUT-high (≥4) and CONUT-low (≤3), according to time-dependent receiver operating characteristic (ROC) analysis. The associations of CONUT with clinicopathological factors and survival were evaluated. CONUT-high patients were significantly older (p nutritional status but also for predicting long-term OS in gastric cancer patients after curative resection.

  10. The curative effect of donepezil combined with mouse nerve growth factor on treating patients with Alzheimer’s disease%多奈哌齐联合鼠神经生长因子治疗阿尔茨海默病48例临床观察

    Institute of Scientific and Technical Information of China (English)

    李晴; 秦琴保

    2014-01-01

    目的:探讨多奈哌齐联合鼠神经生长因子联合治疗阿尔茨海默病的临床疗效。方法48例患者随机分为2组,分别接受多奈哌齐或多奈哌齐联合鼠神经生长因子治疗,总疗程12周,根据MMSE、ADL、ADAS‐cog量表评价2组治疗前后认知功能及生活能力变化。结果2组在日常生活能力及缓解认知功能的减退方面,显示有效;且联合治疗组较单纯使用多奈哌齐组在MMSE和ADL评分上改善更为显著。结论多奈哌齐联合鼠神经生长因子治疗能有效改善AD患者的认知、行为能力,并且具有良好安全性。%Objective To investigate the curative effect of donepezil combined with mouse nerve growth factor on treating patients with Alzheimer’s disease (AD). Methods 48 patients with AD were divided into donepezil group (treated with done‐pezil) and combined treatment group (treated with donepezil combined with mouse nerve growth factor ). 12 weeks after treat‐ment, the cognitive function and viability of two groups were evaluated by the Mini‐Mental State Examination (MMSE), Ac‐tivities of Daily Living(ADL),Alzheimer’s disease Assessment Scale cognitive subscale(ADAS‐cog). Results function and viability of two groups were significantly improved,and the MMSE and ADL score of combined treaTthmeencotggnriotiuvpe were better than these of donepezil group. Conclusion Donepezil combined with mouse nerve growth factor can effectively improve the cognitive function and viability of AD patients and have better safety.

  11. Lived experiences of everyday life during curative radiotherapy in patients with non-small cell lung cancer: A phenomenological study

    DEFF Research Database (Denmark)

    Petri, Suzanne; Berthelsen, Connie Bøttcher

    2015-01-01

    , anxiety, and reduced quality of life. However, little is known about the patients' experience of everyday life during the care trajectory. DESIGN: This study takes a reflective lifeworld approach using an empirical application of phenomenological philosophy described by Dahlberg and colleagues. METHOD......: A sample of three patients treated with curative radiotherapy for NSCLC was interviewed 3 weeks after the end of radiotherapy treatment about their experiences of everyday life during their treatment. Data were collected in 2014 and interviews and analysis were conducted within the descriptive...

  12. Coping, quality of life, depression, and hopelessness in cancer patients in a curative and palliative, end-of-life care setting.

    Science.gov (United States)

    van Laarhoven, Hanneke W M; Schilderman, Johannes; Bleijenberg, Gijs; Donders, Rogier; Vissers, Kris C; Verhagen, Constans A H H V M; Prins, Judith B

    2011-01-01

    Coping strategies may be important factors influencing quality of life (QOL), depression, and hopelessness. However, most studies on this issue were performed in patients still undergoing anticancer treatment. Unknown is which coping strategies are of importance for palliative-cancer patients who no longer receive treatment. The objectives of this study were to assess coping strategies in curatively treated and palliative-cancer patients no longer receiving anticancer treatment and to examine the relation of these coping strategies with QOL, depression, and hopelessness. A descriptive research design was used. Ninety-two curative and 59 palliative patients filled out the COPE-Easy abbreviated version, the European Organisation for Research-and-Treatment of Cancer QOL-Questionnaire version 2.0, Beck Depression Inventory for Primary Care, and Beck Hopelessness Scale. In both curative and palliative patients, active coping strategies and acceptance were beneficial in terms of QOL, depression, and hopelessness, unlike avoidant coping strategies and venting of emotions. Palliative patients scored higher on the coping strategy, seeking moral support. For the outcome variable, emotional functioning, significant interactions were observed between the variable, curative/palliative care setting, and the coping strategy, seeking moral support. For the outcome variable, role functioning, significant interactions were observed between the variable, curative/palliative care setting, and the coping strategy, waiting. Coping strategies were significantly correlated to QOL, depression, and hopelessness. However, this correlation differed in the curative and palliative, end-of-life care setting. The observed relations between coping strategies, QOL, depression, and hopelessness give room to cognitive-behavioral nursing interventions. Specific attention is needed for differences in coping strategies between curative and palliative patients.

  13. Research on curative effect of traditional Chinese medicine treating low-grade fever of children caused by respiratory system infection.

    Science.gov (United States)

    Li, Xiangyun

    2015-07-01

    This study aims to explore the curative effect of traditional Chinese medicine treating low-grade fever of children caused by respiratory system infection. Sixty children who suffered low-grade fever caused by respiratory system infection were selected and divided into treatment group and control group randomly, each with 30 cases. Control group was treated with conventional methods including oxygen uptake, nebulization and anti-infection, etc, while treatment group was given boil-free granules of traditional Chinese medicine besides the treatment which control group received. Then clinical curative effect of two groups was compared. Results showed that 28 cases (93.3%) were cured in treatment group; while 21 cases (70.0%) were cured in control group. Compared with control group, the treatment group showed up better treatment efficiency and the difference between groups was of statistical significance (Pfever of children caused by respiratory system infection; characterized by short treatment cycle and effective treatment effect, Chinese medicine granules in the combination with oxygen atomization inhalation is proved to be able to efficiently remit symptoms such as coughing, gasp and labored breathing, with outstanding curative effect in the treatment of low-grade fever of children caused by respiratory system infection, thus it is worthy of popularization and application clinically.

  14. Postoperative Helicobacter pylori Infection as a Prognostic Factor for Gastric Cancer Patients after Curative Resection.

    Science.gov (United States)

    Jung, Da Hyun; Lee, Yong Chan; Kim, Jie-Hyun; Chung, Hyunsoo; Park, Jun Chul; Shin, Sung Kwan; Lee, Sang Kil; Kim, Hyoung-Il; Hyung, Woo Jin; Noh, Sung Hoon

    2017-09-15

    Few studies have evaluated the effect of Helicobacter pylori infection on the prognosis of patients diagnosed with gastric cancer (GC) after curative surgery. We investigated the association between the H. pylori infection status and clinical outcome after surgery. We assessed the H. pylori status of 314 patients who underwent curative resection for GC. The H. pylori status was examined using a rapid urease test 2 months after resection. Patients were followed for 10 years after surgery. An H. pylori infection was observed in 128 of 314 patients. The median follow-up period was 93.5 months. A Kaplan-Meier analysis indicated that patients with H. pylori had a higher cumulative survival rate than those who were negative for H. pylori. Patients with stage II cancer who tested negative for H. pylori were associated with a poor outcome. In a multivariate analysis, H. pylori-negative status was a significant independent prognostic factor for poor overall survival. Having a negative H. pylori infection status seems to indicate poor prognosis for patients with GC who have undergone curative resection. Further prospective controlled studies are needed to evaluate the mechanism by which H. pylori affects GC patients after curative surgery in Korea.

  15. Patient Preferences for the Disclosure of Prognosis After Esophagectomy for Cancer with Curative Intent

    NARCIS (Netherlands)

    Lagarde, Sjoerd M.; Franssen, Sanne J.; van Werven, Jochem R.; Smets, Ellen M. A.; Tran, T. C. Khe; Tilanus, Hugo W.; Plukker, John Th. M.; de Haes, Johanna C. J. M.; van Lanschot, J. Jan B.

    2008-01-01

    Introduction: The aim of this study was to determine the preferences for content, style, and format of prognostic information of patients after potentially curative esophagectomy for cancer and to explore predictors of these preferences. Patients and Methods: This multicenter study included a consec

  16. 薄荷油湿热敷治疗维持性血液透析患者便秘的疗效观察%The curative effect observation on peppermint oil moist heat compress for treating constipation patients with maintained hemodialysis

    Institute of Scientific and Technical Information of China (English)

    张静静; 江桂林; 田远如; 徐静

    2014-01-01

    Objective To explore the curative effect and nursing experience of peppermint oil moist heat compress on the abdomen in onstipation patients with maintained hemodialysis. Methods 60 cases of constipation patients with maintained hemodialysis were randomly divided into observer group and control group with 30 cases in each group. The observer group were treated with peppermint oil moist heat compress on the abdomen,the control group took 3-6g Senna of bubble water at a draught and treatment courses were both 2 weeks. The first defecation time , reaction of patients during defecation, the independent defecation time,duration time and adverse reaction were observed and recorded between two groups. Results Effective rate of observer group is significantly higher than the control group, so there is significant difference between two groups (P<0.05).Conclusion Peppermint oil moist heat compress on the abdomen not only may help maintained hemodialysis patients maintain smooth stool,which is no side effect,and simple operation, but can reduce the discomfort and complication of constipations,and then improve life quality of the patients.%目的:探讨薄荷油腹部湿热敷对维持性血液透析患者便秘的疗效。方法将60例维持性血液透析便秘患者随机分为观察组与对照组各30例,观察组患者采用薄荷油腹部湿热敷,对照组给予番泻叶3~6 g泡水顿服,疗程均为2周。观察2组患者的疗效及排便时患者的反应。结果观察组总有效率明显高于对照组,2组比较差异有统计学意义(P<0.05)。结论薄荷油腹部湿热敷操作简单,无副作用,不仅可以使维持性血液透析患者保持大便通畅,而且可以减少因便秘引起的不适和并发症,进而提高患者的生活质量。

  17. Observation of the Curative Effect of Mabthera in Combination with the CHOP Regimen in Treating Invasive B-Cell Lymphoma: A Report of 45 Cases

    Institute of Scientific and Technical Information of China (English)

    Yuerong Shuang; Daqian Ye; Jianxiang Chen; Yaohua Wu; Hui Huang; Guanghua Fan

    2008-01-01

    OBIECTIVE To observe the clinical efficacy and toxic effects of Mabthera(rituximab)in combination with the CHOP(R-CHOP)regimen for treating invasive B-cell non-Hodgkin's lymphoma.METHODS A total of 45 patients with CD20 positive B-cell non-Hodgkin's lymphoma were randomly divided into the R-CHOP(22 cases) and CHOP groups(23 cases for controls).They received the regimens of Mabthera in combination with CHOP or single CHOP therapy respectively.An appraisement of the curative effect could only be performed following 4 cycles of chemotherapy for the 45 patients.Follow-up was conducted to observe the conditions ot survival.RESULTS The rate of complete remission(CR)in the R-CHOP group was 68.2%,with a total effective rate of 81.8%,and in the CHOP group these rates were 34.8% and 78.3%respectively.There was a significant difference in comparing the CR rates between the two groups (P0.05).Adverse effects related to the Mabthera infusions occurred in 6 cases of the R-CHOP group(27.2%).These effects lessened after symptomatic treatment.CONCLUSION The therapeutic regimen Of Mabthera,in combination with CHOP(R-CHOP)has an obvious curative effect for treating invasive B-cell non-Hodgkin's lymphoma,with a favorable tolerance.It is highly recommended as the treatment ot choice.

  18. 慢性肾功能衰竭肾性骨病患者采取骨化三醇治疗的疗效观察%Observe Curative Effect of Using Calcitriol to Treat Chronic Renal Failure Renal Osteopathy Patients

    Institute of Scientific and Technical Information of China (English)

    吴勇; 林克宣

    2013-01-01

      目的:关于将骨化三醇用于治疗慢性肾功能衰竭肾性骨病患者所取得的疗效进行分析探讨。方法:选取在笔者所在医院接受治疗的66例慢性肾功能衰竭肾性骨病患者,将患者随机分成两组。对照组患者进行常规治疗。实验组患者在进行常规治疗的同时采用骨化三醇治疗。比较并观察两组患者治疗后各指标的变化情况,以及观察治疗后两组患者出现不良反应的情况。结果:两组患者进行不同方法治疗后,实验组血清钙(2.46±0.39)mmol/L明显高于对照组(1.99±0.37)mmol/L,比较差异有统计学意义(P<0.05)。实验组血磷、碱性磷酸酶、尿素氮、肌酐明显低于对照组,比较差异有统计学意义(P<0.05)。结论:采用骨化三醇用于治疗慢性肾功能衰竭肾性骨病比常规治疗的效果好,可以加快钙的吸收,降低患者体内血磷、碱性磷酸酶、尿素氮、肌酐水平,可有效改善肾性骨病,且不良反应发生率低,在临床上可以广泛运用。%Objective:To discuss and analyze curative effect of using calcitriol to treat chronic renal failure renal osteopathy patients.Method:Chose 66 cases of these chronic renal failure renal osteopathy patients who have been treated at our hospital,divided them into control group and experimental group randomly.Proceeded conventional treatment to control group’s patients,while added calcitriol to experimental group’s patients on the basis of conventional treatment.Compared and observed these two groups’patients’change situations of various indexes after treatment,and observed their happening conditions of adverse reactions after treatment.Result:After these two groups patients received different treatments,experimental group’s serum calcium content(2.46±0.39)mmol/L was obviously higher than control group’s(1.99±0.37)mmol/L,it has statistics meaning(P<0.05). Experimental group’s blood

  19. Application of the new 8th TNM staging system for non-small cell lung cancer: treated with curative concurrent chemoradiotherapy.

    Science.gov (United States)

    Choi, Hoon Sik; Jeong, Bae Kwon; Jeong, Hojin; Lee, Yun Hee; Ha, In Bong; Song, Jin Ho; Kang, Ki Mun

    2017-07-21

    The eighth tumor, node, metastasis (TNM) staging system (8-TNM) for non-small cell lung cancer (NSCLC) was newly released in 2015. This system had limitation because most patients included in the analysis were treated with surgery. Therefore, it might be difficult to reflect prognosis of patients treated with curative concurrent chemoradiotherapy (CCRT). Purpose of this study was to investigate clinical impact of the newly published 8-TNM compared to the current seventh TNM staging system (7-TNM) for locally advanced NSCLC patients treated with CCRT. New 8-TNM was applied to 64 patients with locally advanced NSCLC who were treated with CCRT from 2010 to 2015. Changes in T category and stage group by 8-TNM were recorded and patterns of change were evaluated. Survival was analyzed according to T category, N category, and stage group in each staging system, respectively. Among the total of 64 patients, 38 (59.4%) patients showed change in T category while 22 (34.4%) patients showed change in stage group using 8-TNM compared to 7-TNM. Survival curves were significantly separated in the 8-TNM stage group (p = 0.001) than those in the 7-TNM (p > 0.05). Especially, survival of newly introduced stage IIIC by 8-TNM was significantly lower than that of others. On the other hand, there was no significant survival difference between T categories in each staging system. Subdivision of stage III into IIIA, IIIB, and IIIC by 8-TNM for patients treated with CCRT better reflected prognosis than 7-TNM. However, subdivision of T category according to tumor size in 8-TNM might be less significant.

  20. Curative Effect of Acupuncture and Rehabilitation Training in Treating Hemiplegia After Stroke

    Institute of Scientific and Technical Information of China (English)

    LIU Jin-feng

    2005-01-01

    Patients of post-stroke hemiplegia were divided into acupuncture and rehabilita tion training group (n = 50), acupuncture group (n = 32), and rehabilitation training group (n= 31), and treated with acupuncture and/or rehabilitation training. The patients' moving ability and capability of daily life were estimated before and after treatment. The total effective rate in the acupuncture and rehabilitation training group was higher than those in the acupuncture group and the rehabilitation training group (P< 0.01), and there was no difference between the acupuncture group and the rehabilitation group (P > 0.05). The method of acupuncture combining rehabilitation training is an effective therapy for treating post-stroke hemiplegia.%将中风偏瘫患者分为针灸结合康复训练组(n=50),针灸组(n=32),康复训练组(n=31),采用针刺治疗和康复训练.在治疗前后对患者偏瘫肢体的运动功能和日常生活能力进行评定.总有效率针灸结合康复训练组明显高于针灸组和康复训练组(P<0.01),而针刺组和康复组的总有效率比较无明显差异(P>0.05).针灸结合康复训练是治疗中风偏瘫的有效方法.

  1. When a Patient Declines Curative Care: Management of a Ruptured Aortic Aneurysm

    Directory of Open Access Journals (Sweden)

    Sangeeta Lamba

    2013-09-01

    Full Text Available The management of major vascular emergencies in the emergency department (ED involves rapid, aggressive resuscitation followed by emergent definitive surgery. However, for some patients this traditional approach may not be consistent with their goals and values. We explore the appropriate way to determine best treatment practices when patients elect to forego curative care in the ED, while reviewing such a case. We present the case of a 72-year-old patient who presented to the ED with a ruptured abdominal aortic aneurysm, but refused surgery. We discuss the transition of the patient from a curative to a comfort care approach with appropriate direct referral to hospice from the ED. Using principles of autonomy, decision-making capacity, informed consent, prognostication, and goals-of-care, ED clinicians are best able to align their approach with patients’ goals and values. [West J Emerg Med. 2013;14(5:555–558.

  2. Investigation the Curative Effect of the Endogenetic Field Thermotherapy Treated that Patients the Venous Thrombosis of Lower Limb Combined with Malignant Tumour%内生场热疗治疗恶性肿瘤并发的下肢静脉血栓疗效观察

    Institute of Scientific and Technical Information of China (English)

    金美四; 李一辉

    2015-01-01

    Objective To observe the curative ef ect by means of fourty-six cases of the venous thrombosis of lower limb combined with malignant tumour were treated by endogenetic field thermotherapy from the July of 2012 to July of 2014.Methods Fourty-six cases in accordance with the wishes of patients into two groups.one group is anticoagulant therapy alone (the observation group).the other is anticoagulant therapy and endogenetic field thermotherapy (the control group) to groups were observed the hospitalization time ,Karnofsky score ,improvement of pain, treatment ef ect ,untoward ef ect. Results The control group average hospitalization is eleven point four day, the observation group average hospitalization is thirteen point five day. the control group cure rate ,and has the obvious curative ef ect, significant improvement in pain and Karnofsky score, there were have statistical y significant dif erence with the observation group. twenty-three cases the endogenetic field thermotherapy treated is only two case local skin redness,no other adverse reaction. Conclusion The endogenetic field thermotherapy treated that patients the venous thrombosis of lower limb combined with malignant tumour is a safe, ef ective, no serious adverse reaction and a worth popularizing therapeutic tool.%目的通过回顾性分析2012年7月~2014年7月在我科住院的46例恶性肿瘤并发的下肢静脉血栓患者的临床资料,观察内生场热疗治疗恶性肿瘤并发的下肢静脉血栓疗效。方法将入住我科的46例患者按患者治疗意愿随机分为单纯抗凝治疗组(对照组)及抗凝治疗联合内生场热疗治疗组(观察组),观察两组患者住院时间,KPS评分,疼痛改善情况,治疗效果、不良反应。结果观察组平均住院日为11.4d,对照组为13.5d,观察组23例患者中治愈12例(52.17%),显效6例(26.08%),有效3例(13.04%),无效2例(8.7%),取得明显疗效的共18例(78.26%);对照组23例患者中治愈5

  3. Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation.

    Directory of Open Access Journals (Sweden)

    Bang Wool Eom

    Full Text Available A small number of nomograms have been previously developed to predict the individual survival of patients who undergo curative resection for gastric cancer. However, all were derived from single high-volume centers. The aim of this study was to develop and validate a nomogram for gastric cancer patients using a multicenter database.We reviewed the clinicopathological and survival data of 2012 patients who underwent curative resection for gastric cancer between 2001 and 2006 at eight centers. Among these centers, six institutions were randomly assigned to the development set, and the other two centers were assigned to the validation set. Multivariate analysis using the Cox proportional hazard regression model was performed, and discrimination and calibration were evaluated by external validation.Multivariate analyses revealed that age, tumor size, lymphovascular invasion, depth of invasion, and metastatic lymph nodes were significant prognostic factors for overall survival. In the external validation, the concordance index was 0.831 (95% confidence interval, 0.784-0.878, and Hosmer-Lemeshow chi-square statistic was 3.92 (P = 0.917.We developed and validated a nomogram to predict 5-year overall survival after curative resection for gastric cancer based on a multicenter database. This nomogram can be broadly applied even in general hospitals and is useful for counseling patients, and scheduling follow-up.

  4. Surveillance of patients following surgery with curative intent for colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Surveillance after resection of colorectal cancer with curative intent is an important component of post-operative care. Clinical review, imaging, colonoscopy, and cost to the community are among significant issues to consider in planning a surveillance regime. This review aims to identify the available evidence for the use of surveillance and its individual components. The literature pertaining to follow-up of patients following potentially curative surgery for colorectal cancer was reviewed in order to formulate a summary of the wide range of clinical practice. There is evidence of improved survival of patients undergoing more intense follow-up compared with those having minimal surveillance, with an estimated overall 5-year gain of up to 10%. The efficacy of individual components of follow-up regimes remains unclear, but an review, liver imaging, and colonoscopy appears to be of benefit It is cost-effective and can be specialist or community-based.

  5. Tumor Marker Levels Before and After Curative Treatment of Hepatocellular Carcinoma as Predictors of Patient Survival.

    OpenAIRE

    Nanashima, Atsushi; Taura, Naota; Abo, Takafumi; ICHIKAWA, TATSUKI; Sakamoto, Ichiro; Nagayasu, Takeshi; Nakao, Kazuhiko

    2011-01-01

    BACKGROUND: α-fetoprotein (AFP) is used as a marker for hepatocellular carcinoma (HCC), which is influenced by hepatitis. Protein-induced vitamin K absence or antagonist II (PIVKA-II) is a sensitive diagnostic marker. Changes in these markers after treatment may reflect curability and predict outcome. METHODS: We conducted an analysis of prognosis in 470 HCC patients who received curative treatments, and examined the relationship between changes in AFP and PIVKA-II levels after 1 month of tre...

  6. Prognostic associations of preoperative plasma levels of fibrinogen and D-dimer after curative resection in patients with colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    王俊锋

    2013-01-01

    Objective To explore the associations of preoperative plasma levels of fibrinogen and D-dimer with clinico-pathologic parameters and overall survival in colorectal cancer patients after curative resection.Methods From

  7. Prognostic nomogram for patients with hepatocellular carcinoma underwent adjuvant transarterial chemoembolization following curative resection

    Science.gov (United States)

    Jing, Chu-Yu; Fu, Yi-Peng; Zheng, Su-Su; Yi, Yong; Shen, Hu-Jia; Huang, Jin-Long; Xu, Xin; Lin, Jia-Jia; Zhou, Jian; Fan, Jia; Ren, Zheng-Gang; Qiu, Shuang-Jian; Zhang, Bo-Heng

    2017-01-01

    Abstract Adjuvant transarterial chemoembolization (TACE) is a major option for postoperative hepatocellular carcinoma (HCC) patients with recurrence risk factors. However, individualized predictive models for subgroup of these patients are limited. This study aimed to develop a prognostic nomogram for patients with HCC underwent adjuvant TACE following curative resection. A cohort comprising 144 HCC patients who received adjuvant TACE following curative resection in the Zhongshan Hospital were analyzed. The nomogram was formulated based on independent prognostic indicators for overall survival (OS). The performance of the nomogram was evaluated by the concordance index (C-index), calibration curve, and decision curve analysis (DCA) and compared with the conventional staging systems. The results were validated in an independent cohort of 86 patients with the same inclusion criteria. Serum alpha-fetoprotein (AFP), hyper-sensitive C-reactive protein (hs-CRP), incomplete tumor encapsulation, and double positive staining of Cytokeratin 7 and Cytokeratin 19 on tumor cells were identified as independent predictors for OS. The C-indices of the nomogram for OS prediction in the training cohort and validation cohort were 0.787 (95%CI 0.775–0.799) and 0.714 (95%CI 0.695–0.733), respectively. In both the training and validation cohorts, the calibration plot showed good consistency between the nomogram-predicted and the observed survival. Furthermore, the established nomogram was superior to the conventional staging systems in terms of C-index and clinical net benefit on DCA. The proposed nomogram provided an accurate prediction on risk stratification for HCC patients underwent adjuvant TACE following curative resection. PMID:28296727

  8. Secondary oesophageal or gastric cancer in patients treated for head and neck squamous cell carcinoma

    DEFF Research Database (Denmark)

    Andersen, Anja Rosenlund; Bjerring, Ole Steen; Godballe, Christian

    2016-01-01

    , to examine possible risk factors of developing SPMs. METHODS: Data on all patients treated for HNSCC with curative intent in the Region of Southern Denmark in the period between 1 January 2000 and 31 December 2010 were reviewed. A total of 1,172 patients were identified. The combined data from the DAHANCA...

  9. Curative effect of Tai Chi exercise in combination with auricular plaster therapy on improving obesity patient with secondary hyperlipidemia.

    Science.gov (United States)

    Song, Qinghua; Yuan, Yandong; Jiao, Chun; Zhu, Ximei

    2015-01-01

    Observe the effect of Tai Chi in combination with auricular plaster therapy on treating obesity patient with secondary hyperlipidemia. Select 45 patients who suffer from simple obesity and secondary hyperlipidemia and then adopt random digital table to divide them into a Tai Chi group, an auricular plaster therapy group and a combination group. Each group consists of 15 patients. The patients in Tai Chi group are trained with Tai Chi twice a day, while those in auricular plaster therapy are treated with auricular plaster therapy 3-5 times a day and those in the combination group are trained with Tai Chi and auricular plaster therapy twice a day. BMI, body fat percentage and blood lipid indexes are respectively detected for the selected patients in the three groups before treatment and after 180 days' treatment. After 180 days' treatment, BMI index and body fat percentage of Tai Chi group are significantly improved in comparison with those before treatment (Pplaster therapy group are not improved obviously in comparison with those before the treatment (P>0.05) but the blood lipid index is improved significantly (Pplaster therapy can show the obvious synergistic therapeutic effect and thus the combined curative effect is obviously superior to that of the single therapy method.

  10. Lived experiences of everyday life during curative radiotherapy in patients with non-small-cell lung cancer: A phenomenological study

    Directory of Open Access Journals (Sweden)

    Suzanne Petri

    2015-11-01

    Full Text Available Aim: To explore and describe the essential meaning of lived experiences of the phenomenon: Everyday life during curative radiotherapy in patients with non-small-cell lung cancer (NSCLC. Background: Radiotherapy treatment in patients with NSCLC is associated with severe side effects such as fatigue, anxiety, and reduced quality of life. However, little is known about the patients’ experience of everyday life during the care trajectory. Design: This study takes a reflective lifeworld approach using an empirical application of phenomenological philosophy described by Dahlberg and colleagues. Method: A sample of three patients treated with curative radiotherapy for NSCLC was interviewed 3 weeks after the end of radiotherapy treatment about their experiences of everyday life during their treatment. Data were collected in 2014 and interviews and analysis were conducted within the descriptive phenomenological framework. Findings: The essential meaning structure of the phenomenon studied was described as “Hope for recovery serving as a compass in a changed everyday life,” which was a guide for the patients through the radiotherapy treatment to support their efforts in coping with side effects. The constituents of the structure were: Radiotherapy as a life priority, A struggle for acceptance of an altered everyday life, Interpersonal relationships for better or worse, and Meeting the health care system. Conclusion: The meaning of hope was essential during radiotherapy treatment and our results suggest that interpersonal relationships can be a prerequisite to the experience of hope. “Hope for recovery serving as a compass in a changed everyday life,” furthermore identifies the essentials in the patients’ assertive approach to believing in recovery and thereby enabling hope in a serious situation.

  11. Curative Effects of Dendritic Cells Combined with Cytokine-Induced Killer Cells in Patients with Malignant Pericardial Effusion

    Science.gov (United States)

    Wang, Hongmin; Cui, Yuzhong; Wang, Sheng; Zhao, Rusen; Sun, Ming

    2016-01-01

    Background To determine the effects of dendritic cells (DCs) and cytokine-induced killer (CIK) cells in patients with malignant pericardial effusion. Material/Methods All patients underwent pericardial puncture and indwelling catheter insertion. After pericardial drainage, the 16 patients in the treatment group received an infusion of 20 mL DCs and CIK cells (>1.0×1010 cells) and 500,000 U interleukin (IL)-2 for 3 successive days. The 15 control-group patients received 30 mg/m2 cisplatin and 500,000 U IL-2 for 3 successive days. The treatment effects were assessed using imaging data. Results The total efficiency and complete remission rates were higher in the treatment group than in the control group at 4 weeks (total efficiency: 87.50% vs. 73.33%; complete remission: 62.50% vs. 46.67%) and 3 months after the treatment (total efficiency: 81.25% vs. 66.67%; complete remission: 50.00% vs. 40.00%; P<0.05 for all). In both groups, the Karnofsky scores for quality of life improved after treatment. However, the curative effects were better in the treatment group than in the control group (P<0.05). The following adverse reactions occurred: fever, 6 treatment-group patients and 3 control-group patients; chest pain, 2 treatment-group patients and 7 control-group patients; gastrointestinal reactions, 1 treatment-group patient and 6 control-group patients; and bone marrow suppression, 1 treatment-group patient and 5 control-group patients. The between-group differences in adverse reactions were significant (P<0.05). Conclusions The combination of DCs and CIK cells effectively treated malignant pericardial effusion, produced few side effects, and improved the patients’ quality of life. PMID:27806024

  12. Planned FDG PET-CT Scan in Follow-Up Detects Disease Progression in Patients With Locally Advanced NSCLC Receiving Curative Chemoradiotherapy Earlier Than Standard CT

    DEFF Research Database (Denmark)

    Pan, Yi; Brink, Carsten; Schytte, Tine;

    2015-01-01

    The role of positron emission tomography-computed tomography (PET-CT) in surveillance of patients with nonsmall cell lung cancer (NSCLC) treated with curatively intended chemoradiotherapy remains controversial. However, conventional chest X-ray and computed tomography (CT) are of limited value...... in discriminating postradiotherapy changes from tumor relapse. The aim of this study was to evaluate the clinical value of PET-CT scan in the follow-up for patients with locally advanced (LA) NSCLC receiving concomitant chemoradiotherapy (CCRT).Between 2009 and 2013, eligible patients with stages IIB-IIIB NSCLC...... were enrolled in the clinical trial NARLAL and treated in Odense University Hospital (OUH). All patients had a PET-CT scan scheduled 9 months (PET-CT9) after the start of the radiation treatment in addition to standard follow-up (group A). Patients who presented with same clinical stage of NSCLC...

  13. Treating statin-intolerant patients

    Directory of Open Access Journals (Sweden)

    Pigna G

    2011-04-01

    Full Text Available Marcello Arca, Giovanni PignaAtherosclerosis Unit, Department of Internal Medicine and Allied Medical Specialities, Sapienza University of Rome, Rome, ItalyAbstract: Statins are effective in reducing cardiovascular events and are safe for almost all patients. Nevertheless, intolerance to statins is frequently faced in clinical practice. This is mostly due to muscular symptoms (myalgia with or without increase of plasma creatinine kinase and/or elevation of hepatic aminotransferases, which overall constitutes approximately two-thirds of reported adverse events during statin therapy. These side effects raise concerns in patients as well as in doctors and are likely to reduce patients' adherence and, as a consequence, the cardiovascular benefit. Therefore, it is mandatory that clinicians improve their knowledge on the clinical aspects of muscular and hepatic side effects of statin therapy as well as their ability to manage patients with statin intolerance. Besides briefly examining the clinical aspects and the mechanisms that are proposed to be responsible for the most common statin-associated side effects, the main purpose of this article is to review the available approaches to manage statin-intolerant patients. The first step is to determine whether the adverse events are indeed related to statin therapy. If so, lowering the dosage or changing statin, alternate dosing options, or the use of nonstatin compounds may be practical strategies. The cholesterol-lowering potency as well as the usefulness of these different approaches in treating statin-intolerant patients will be examined based on currently available data. However, the cardiovascular benefit of these strategies has not been well established, so their use has to be guided by a careful clinical assessment of each patient.Keywords: statin therapy, atorvastatin, rosuvastatin, aminotransferase levels, myopathy

  14. 康复新湿敷治疗褥疮的疗效观察%Curative effect observation of treating bedsore by Kangfuxin lition wet-compressing therapy

    Institute of Scientific and Technical Information of China (English)

    罗华; 张海燕; 王黎明

    2009-01-01

    Objective To observe the curative effect of treating bedsore by Kangfuxin Lotion wet-compressing therapy. Methods 30 patients with bedsore (stage Ⅱ or stage Ⅲ) were randomly divided into two groups, each group contains 15 pa-tients. Besides conventional nursing and strengthened nutrition,they all received local debridement with medicine. For the treat-ment group, we clung Kangfuxin-dipped compress to the wound, eovered it with axenic dry gauze, and fix it with adhesive plas-ter. For the control group, we plastered the wound with 0.5% iodophor, and persistingly covered iodophor-dipped gauze on the wound. For both groups, we renew the compress three times a day so as to ensure the continuity of medicine effect and the wettish condition of the wound. Results The total effective rate of the treatment group was 93.3%, while that of the control group was 66.7%. Compared with the control group, the curative rate of the treatment group was much higher and its healing time was shor-ter, the discrepant was very obvious (P<0.01). Conclusion Kangfuxin Lotion, which is convenient to use and with low price, can greatly enhance the curative rate and shorten the healing time.%目的 观察康复新湿敷治疗褥疮的疗效.方法 30例患有Ⅱ期或Ⅲ期褥疮的患者,随机分为两组,各15例,两组患者除常规护理及加强营养外,均局部清创用药,治疗组用浸有康复新滴剂的棉球紧贴在创面上,外用无菌干纱布覆盖,胶布固定,每日换药3次,以保持药效的连续性和保证创面处于湿润状态.对照组用0.5%碘伏涂擦,并用碘伏纱布持续湿敷覆盖创面,每日换药3次.结果 观察治疗组总有效率为93.3%,对照组总有效率为66.7%.两组患者的治愈率及治愈时间比较,差异均有统计学意义(P<0.01),治疗组明显优于对照组.结论 康复新液治疗褥疮可明显提高治愈率,使愈合时间缩短,且操作简便,治疗费用低廉.

  15. Individualized Comprehensive Lifestyle Intervention in Patients Undergoing Chemotherapy with Curative or Palliative Intent: Who Participates?

    Directory of Open Access Journals (Sweden)

    Karianne Vassbakk-Brovold

    Full Text Available Knowledge about determinants of participation in lifestyle interventions in cancer patients undergoing chemotherapy, particularly with palliative intent, remains poor. The objective of the present study was to identify determinants of participating in a 12 month individualized, comprehensive lifestyle intervention, focusing on diet, physical activity, mental stress and smoking cessation, in cancer patients receiving chemotherapy with curative or palliative intent. The secondary objective was to identify participation determinants 4 months into the study.Newly diagnosed cancer patients starting chemotherapy at the cancer center in Kristiansand/Norway (during a 16 month inclusion period were screened. Demographic and medical data (age, sex, body mass index, education level, marital status, smoking status, Eastern Cooperative Oncology Group performance status (ECOG, diagnosis, tumor stage and treatment intention was analyzed for screened patients.100 of 161 invited patients participated. There were more females (69 vs. 48%; P = 0.004, breast cancer patients (46 vs. 25%; P = 0.007, non-smokers (87 vs. 74%; P = 0.041, younger (mean age 60 vs. 67 yrs; P 70 years were less likely to participate at baseline and 4 months.Individualized lifestyle interventions in cancer patients undergoing chemotherapy appear to facilitate a high participation rate that declines with increasing age; both during the enrollment process and completing the intervention. Neither oncologic nor socioeconomic variables deterred participation.

  16. Heart failure in patients treated with bisphosphonates

    DEFF Research Database (Denmark)

    Grove, Erik; Abrahamsen, B; Vestergaard, P

    2013-01-01

    The aim of this study was to investigate the occurrence of heart failure in patients treated with bisphosphonates.......The aim of this study was to investigate the occurrence of heart failure in patients treated with bisphosphonates....

  17. A curative immune profile one week after treatment of Indian kala-azar patients predicts success with a short-course liposomal amphotericin B therapy.

    Directory of Open Access Journals (Sweden)

    Smriti Mondal

    Full Text Available BACKGROUND: The present pilot study investigating the minimum dose for short-course single and double-dose treatment of kala-azar with an apparently new liposomal formulation of amphotericin B, Fungisome, led to identification of immunological components for early detection of success and/or failure to cure. METHODS: Patients were treated with 5, 7.5 (single-dose and 10 mg/kg body weight (5 mg/kg double-dose of Fungisome. Immunological investigations involving plasma cytokines and antigen-specific lymphoproliferation and cytokine responses from PBMCs were carried out before, 1 week after Fungisome treatment, at the time of relapse, and again after conventional amphotericin B treatment. RESULTS: At 1-month follow-up all the patients showed 100% initial cure. However, total doses of 5, 7.5 and 10 mg/kg Fungisome showed 60%, 50% and 90% cure, respectively, at 6-months posttreatment. Patients successfully cured demonstrated downregulation of IL-12 and IL-10 in plasma, and two-fold or more elevation of IFN-gamma, IL-12 and TNF, and significant down-regulation of IL-10 and TGF-beta in culture supernatants 1-week posttreatment irrespective of drug-dose. A differential immune profile, involving insignificant decline in IL-10 and IL-12 in plasma and negligible elevation of IFN-gamma, IL-12 and TNF, and persistence of IL-10, despite decline in TGF-beta in culture supernatants, in apparently cured individuals, corresponded with relapse within 6-months of treatment. CONCLUSION: Immunological investigations revealed significant curative and non-curative immunomodulation 1-week posttreatment, correlating with successful cure and relapse, respectively. Although immune-correlation was dose-independent, almost consistent curative response in patients treated with the highest dose 10 mg/kg reflected a definitive impact of the higher-dose on the immune response. TRIAL REGISTRATION NAME AND NUMBER: Clinical Trials Registry--India (CTRI CTRI/2009/091/000764.

  18. 气发声法治疗小儿生理性口吃 78例%Curative effect of physiological stammering using air vocalism in 78 child patients

    Institute of Scientific and Technical Information of China (English)

    王吉; 何玲; 肖志伟; 王旭霞

    2002-01-01

    Background: The physiological stammering in children can easily develop into balbuties if not treated in time.Balbuties can exert negative effect on the development of the patient child's psychology and the formation of his or her personality.Since 1998, we have been using the air vocalism to treat the physiological stammering in children and have achieved satisfying curative effect.The report is as following.

  19. Analysis on the curative effect of traditional Chinese medicine massage treating Insomnia%中医推拿治疗失眠的疗效分析

    Institute of Scientific and Technical Information of China (English)

    马学林

    2016-01-01

    To analyze the clinical effect of treating insomnia by TCM massage. Methods 150 patients with functional insomnia treated in our hospital from June 2010 to August, were randomly divided into control group and observation group. Estazolam drug treatment were adopted in the control group, the observation group taking Chinese medicine and massage therapy, the treatment lasted for 1 month and compared two groups of patients with clinical curative effect. Results In the observation group, the effective rate was 97.33%, the effective rate was 57, and the control group was 73 cases, the effective rate was 76%, the observation group was significantly better than the control group, the difference was statistically significant (P < 0.01, χ2=14.77). Conclusion TCM Massage has the advantages of high safety, the treatment effect is remarkable, and the medicine treatment has no side effect. It should be considered as an effective measure to treat the functional insomnia.%目的:分析中医推拿治疗失眠的临床疗效。方法:选取2010年6月~2014年8月期间来我院接受治疗的150例功能性失眠症患者为研究对象,将其随机均分为对照组和观察组。对照组采取舒乐安定药物治疗,观察组采取中医推拿治疗,疗程均为1个月,然后比较两组患者的临床疗效。结果:观察组中,治疗有效73例,有效率为97.33%;对照组中,治疗有效57例,有效率为76.00%;观察组的治疗效果明显优于对照组,差异有统计学意义(P<0.01,χ2=14.77)。结论:中医推拿具有安全性高,治疗效果显著,且较之药物治疗无毒副作用的优势,理应被视为治疗功能性失眠症的有效措施。

  20. Additional treatment with Esberitox in patients submitted to curative adjuvant irradiation after mammary carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Bendel, R.; Bendel, V.; Renner, K.; Stolze, K.

    1988-05-01

    The present prospective, randomized study was conducted with 50 patients submitted to curative adjuvant irradiation following to surgery for mammary carcinoma. The radiotherapy was performed in the same way in all patients with irradiations of the thoracic wall and the regional lymph nodes. Two groups were built by randomization. The study group received an additional treatment with Esberitox, the control group did not receive an additional treatment. As a result, no protective influence of Esberitox could be demonstrated. The parameters investigated were the peripheral blood count (leucocytes, granulocytes, lymphocyts, monocytes, thrombocytes, hemoglobin, hematocrit) and the incidence of infections. This result diverging from literatures is discussed. It is probably affected by volume and extension of the injury induced by a hematotoxic noxa and furthermore by the ability of regeneration. If this ability is exhausted, the protective effect of Esberitox can act no longer. Therefore the essential factor seems to be the duration of exposure to the noxa. Esberitox was effective in case of a short toxicity, it was ineffective in case of prolonged toxicity, if the treatment continuity (noxa) was not broken up by some regeneration intervals. The radiotherapy studied in this trial had a duration of 50 days, and its effect was that of a longterm injury.

  1. Data Curation

    Science.gov (United States)

    Mallon, Melissa, Ed.

    2012-01-01

    In their Top Trends of 2012, the Association of College and Research Libraries (ACRL) named data curation as one of the issues to watch in academic libraries in the near future (ACRL, 2012, p. 312). Data curation can be summarized as "the active and ongoing management of data through its life cycle of interest and usefulness to scholarship,…

  2. Data Curation

    Science.gov (United States)

    Mallon, Melissa, Ed.

    2012-01-01

    In their Top Trends of 2012, the Association of College and Research Libraries (ACRL) named data curation as one of the issues to watch in academic libraries in the near future (ACRL, 2012, p. 312). Data curation can be summarized as "the active and ongoing management of data through its life cycle of interest and usefulness to scholarship,…

  3. A Novel Prognostic Score, Based on Preoperative Nutritional Status, Predicts Outcomes of Patients after Curative Resection for Gastric Cancer.

    Science.gov (United States)

    Liu, Xuechao; Qiu, Haibo; Liu, Jianjun; Chen, Shangxiang; Xu, Dazhi; Li, Wei; Zhan, Youqing; Li, Yuanfang; Chen, Yingbo; Zhou, Zhiwei; Sun, Xiaowei

    2016-01-01

    PURPOSE: We aimed to determine whether preoperative nutritional status (PNS) was a valuable predictor of outcome in patients with gastric cancer (GC). METHODS: We retrospectively evaluated 1320 patients with GC undergoing curative resection. The PNS score was constructed based on four objective and easily measurable criteria: prognostic nutritional index (PNI) score 1, serum albumin nutritional-based prognostic score, is independently associated with OS in GC. Prospective studies are needed to validate its clinical utility.

  4. Do Surgeons Treat Their Patients Like They Would Treat Themselves?

    NARCIS (Netherlands)

    Janssen, S.J.; Teunis, T.; Guitton, T.G.; Ring, D.; Biert, J.

    2015-01-01

    BACKGROUND: There is substantial unexplained geographical and surgeon-to-surgeon variation in rates of surgery. One would expect surgeons to treat patients and themselves similarly based on best evidence and accounting for patient preferences. QUESTIONS/PURPOSES: (1) Are surgeons more likely to reco

  5. Prognostic role of diabetes mellitus in hepatocellular carcinoma patients after curative treatments:a meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Wei-MinWang; YangXu; Xin-RongYang; Yao-HuiWang; Hai-XiangSun; JiaFan

    2011-01-01

    BACKGROUND: The prognostic role of diabetes mellitus (DM) coexisting with hepatocellular carcinoma (HCC) remains controversial. To clarify its impact on survival in HCC patients after curative treatments, a meta-analysis was performed. DATA  SOURCES: Eligible studies were identified through multiple search strategies in the databases PubMed (MEDLINE), EMBASE, the Cochrane Library and ACP Journal Club between January 1950 and March 2010. Ten studies fulfilled the inclusion criteria, and data were aggregated comparing overall survival and recurrence-free survival in HCC patients according to DM status. RESULTS: The pooled hazard ratios (HRs) estimate for overall survival was 1.34 (95% CI, 1.18-1.51; P CONCLUSION: HCC patients with coexisting DM have a shorter survival time and a higher risk for tumor recurrence after curative treatments, while the precise value should be defined in more clinical trials with consistent methodology, especially prospective studies.

  6. Observation of curative effect in antibiotics associated diarrhea children treated by pidotimod and the influence on the inflammation factors and the immune function

    Institute of Scientific and Technical Information of China (English)

    Zhao-Yang Yin; Yao Chen; Ting Zhao

    2016-01-01

    Objective:To explore the curative effect in antibiotics associated diarrhea children treated by pidotimod and the influence on the inflammation factors and the immune function.Methods:A total of 82 cases antibiotic associated diarrhea children were divided into control group and observation group according to random number table method,41 cases in each group, children in two groups were given conventional treatment, on this basis, children in observation group were with pidotimod treatment, they were treated for 2 weeks, compared the clinical efficacy and immune globulin: IgA, IgG, IgM, T cell subgroup: CD3+, CD4+, CD8+, CD4+/CD8+, and inflammation factors: tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Results:The total effective rate in control group was 75.61%,it was significantly lower than 95.12% in observation group; The levels of CD3+,CD4+,CD4+/CD8+, IgA, IgG after treatment in two groups were significantly rised while the levels of TNF-α, IL-6 were significantly reduced than before treatment, The amplitude of index above in observation group was greater than the control group, the difference were all statistically significant.Conclusion: The curative effect in antibiotics associated diarrhea children treated by pidotimodi is obvious, it can reduce inflammation, improve immunity.

  7. Timely meta-analysis on the efficacy of adoptive immunotherapy for hepatocellular carcinoma patients after curative therapy

    Science.gov (United States)

    You, Xue-Mei; Cucchetti, Alessandro; Yuan, Bao-Hong; Li, Ru-Hong; Li, Le-Qun

    2017-01-01

    Aims The role of adoptive immunotherapy (AIT) for patients with hepatocellular carcinoma (HCC) who have received curative therapy is still not well illustrated. This timely meta-analysis aims to update the current evidence on efficacy and safety of AIT for patients with HCC who have received curative therapy. Methods We searched PubMed, EMBASE, Scopus and the Cochrane Library Through January 2017 for relevant studies. Mortality and tumor recurrence were compared between patients with or without adjuvant AIT. The meta-analysis was performed using Review Manager 5.3. Results Eight studies involving 1861 patients met the eligibility criteria and were meta-analyzed. Adjuvant AIT was associated with significantly lower mortality at 1 year (RR 0.64, 95%CI 0.52–0.79), 3 years (RR 0.73, 95%CI 0.65–0.81) and 5 years (RR 0.86, 95%CI 0.79–0.94). Similarly, adjuvant AIT was associated with significantly lower recurrence rate than curative therapies alone at 1 year (RR 0.64, 95%CI 0.49–0.82), 3 years (RR 0.85, 95%CI 0.79–0.91) and 5 years (RR 0.90, 95%CI 0.85–0.95). Short-term outcomes were confirmed in sensitivity analyses based on randomized trials or choice of random- or fixed-effect meta-analysis model. None of the included patients experienced grade 4 adverse events. Conclusions This timely meta-analysis confirms the evidence that adjuvant AIT for patients with HCC after curative treatment lowers risk of mortality and tumor recurrence. PMID:28339493

  8. A contrast study on the curative effect between trepanation and drainage and decompressive craniotomy for treating cerebellar hemorrhage

    Directory of Open Access Journals (Sweden)

    Jie ZHUO

    2014-06-01

    Full Text Available Thirty-three cases of hypertensive cerebellar hemorrhage were involved in this survey, with the bleeding volume over 10 ml. All of them were given external ventricular drainage and then taken continuous monitoring of intracranial pressure (ICP after admission. Within 7-24 h after the onset, they all underwent trepanation and drainage under local anesthesia. In the same period, another 33 cases of cerebellar hemorrhage patients were collected as the control, who met the inclusion criteria and were treated with conventional posterior fossa decompressive craniotomy. As results, the total efficiency of the drilling group was 81.82% (27/33, which was much better than the control group (63.64%, 21/33. However, there was no statistical significance between 2 groups (χ2 = 2.750, P = 0.097. doi: 10.3969/j.issn.1672-6731.2014.06.014

  9. 药物缓释支架治疗无保护左主干病变的近远期疗效%The immediate and long-term curative efficacy of drug-eluting stents in treating patients with unprotected left main coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    朱海军; 赵传艳; 崔连群

    2011-01-01

    目的:观察和评价药物缓释支架(DES)治疗无保护左主干病变(ULMCAD)的有效性和安全性.方法:回顾性分析68例行DES治疗的ULMCAD患者,搜集患者临床资料并应用Syntax积分进行危险分层.定期随访,追踪全因性死亡、心肌梗死、脑卒中、靶血管再次血运重建等主要不良心脑血管事件(MACCE)的发生情况.结果:68例ULMCAD患者中男48例,女20例;年龄(62±10)岁,合并高血压41例,合并糖尿病12例,Syntax积分(25.7±9.7)分.随访(35±16)个月,全因性死亡3例,心肌梗死4例;29例行冠状动脉造影复查,再狭窄并再次PCI 7例;冠状动脉旁路移植术(CABG)1例.1年MACCE 10例(15%),随访终点总MACCE 15例(22%).Syntax积分高危组总MACCE发生率明显高于低中危组(44%对比15%,P﹤0.05).结论:DES治疗ULMCAD安全有效,对Syntax积分小于33分的ULMCAD行介入治疗预后较好.%Objective: To observe and evaluate the validity and safety of drug-eluting stents ( DES) for patients with unprotected left main coronary artery disease (ULMCAD).Methods: The clinical data of patients with ULMCAD who had been treated by DES were collected and reviewed, and Syntax scores were calculated to valuate the risk stratification.The major adverse cardiac cerebral events ( MACCE) were recorded, including all-cause mortality, myocardial infraction, cerebrovascular events and target vessel revascularization.Results: The average age of 68 patients was(62 ± 10)years old, forty-eight of them were male.Forty-one patients suffered from hypertension; twelve patients suffered from type-2 diabetes mellitus.The mean Syntax score was(25.7 ±9.7).And the mean follow-up period was(35 ± 16)months.Three patients died from all causes, 4 patients had myocardial infraction and 1 received coronary artery bypass grafting(CABG).Twenty-nine patients were reexamined by coronary angiography, seven of whom had restenosis and received percutaneous coronary intervention( PCI) again.The occurrence of

  10. Clinical curative effect analysis of 109 cases of patients with brain malignant gliomas treated with operation combined with postoperative radiotherapy%109例脑恶性胶质瘤患者术后联合放射治疗的临床疗效分析

    Institute of Scientific and Technical Information of China (English)

    刘梁; 戈伟; 罗顺祥; 唐甜; 丁万军

    2012-01-01

    目的 观察脑胶质瘤患者术后进一步联合三维适形放疗等综合治疗方式的疗效和安全性.方法 回顾性分析我院109例术后联合放射治疗等多种治疗方式的脑恶性胶质细胞瘤患者的病历资料,对近期疗效和不良反应进行评价,随访时间12~36个月,中位随访时间13个月,计算患者1~3年生存率.结果 109例脑恶性胶质细胞瘤患者均按计划完成治疗,1个月后返院MRI复查结果提示:完全缓解(CR)75例,部分缓解(PR)14例,稳定(SD)13例,疾病进展(PD)7例,客观有效率(RR)为81.6%,疾病探制率(DCR)为93.6%.中位无疾病进展时间(TTP)为14个月,放化疗过程主要毒性表现在脑组织水肿、消化道和骨髓造血功能的抑制等方面.34例患者经MRI检查证实发生放射性脑水肿,发生几率为31.2%.结论 精确的肿瘤切除术后及时的放疗对控制术后残留病灶,完全阻断肿瘤生长根源有重要意义,如能同时接受正规的化疗以及特异性的靶向药物治疗,可收到较好的效果,是目前首选的综合治疗方式.%Objective To observe the efficacy and safety of comprehensive therapy with operation combined with three-dimensional conformal radiotherapy in treating brain malignant gliomas patients. Methods The medical records of 109 cases of brain malignant gliomas, who were treated with combining therapy with operation combined with postoperative radiotherapy were analyzed retrospectively to evaluate their short-term effects and adverse reaction. All the patients were followed up for 12-36 months to calculate their one to three years survival rate, and the median follow-up time was 13 months. Results All the 109 cases of brain malignant gliomas patients were accomplished the therapy on schedule, the MRI review results after a month indicate: CR in 75 cases, PR in 14 cases, SD in 13 cases, PI) in 7 cases. RR accounts for 81.6%, DCR accounts for 93.6%. The median TTP was 14 months. The toxic actions of

  11. Observation on curative effect of moxifloxacin in the treatment of initial-treated smear positive pulmonary tuberculosis patients during intensive chemotherapy%莫西沙星在初治肺结核患者化疗中疗效的观察

    Institute of Scientific and Technical Information of China (English)

    漆沄; 苟超伦; 李炜; 苗凤济; 李冬; 周倩

    2016-01-01

    目的:观察含莫西沙星抗结核方案在初治涂阳肺结核患者强化期化疗中的疗效。方法临床选取3年间我院收治的符合纳入及排除标准的涂阳初治肺结核患者93例。随机分为观察组和对照组,观察组在强化期给予HRZE常规抗结核方案基础上加用莫西沙星,对照组给予HRZE常规抗结核方案。对强化期各治疗时间点的痰菌阴转情况和其他临床指标进行分析。结果观察组第4、6、8周痰结核菌阴转率明显高于对照组(P0. 05). The adverse reactions of the two groups were similar (P>0. 05). Conclusion Moxifloxacin-containing anti-TB program can reduce sputum negative conversion time and improve the negative conversion rate and lesions absorption efficiency in the treatment of initial-treated smear positive pulmonary tuberculosis patients during intensive chemotherapy, with the similar adverse reactions as the control group.

  12. Benefits of intra-operative systemic chemotherapy during curative surgery in patients with locally advanced gastric cancer

    Institute of Scientific and Technical Information of China (English)

    MENG Qing-bin; YU Jian-chun; MA Zhi-qiang; KANG Wei-ming; ZHOU Li; YE Xin

    2013-01-01

    Background There is little information on the impact of intra-operative systemic chemotherapy on gastric cancer.The aim of this study was to identify prognostic factors in patients with locally advanced gastric cancer and undergoing curative resection,with a focus on evaluating survival benefits and tolerance of intra-operative systemic chemotherapy.Methods We retrospectively analyzed clinicopathological data for 264 consecutive patients who underwent curative resection for gastric cancer at Peking Union Medical College Hospital from January 2002 to January 2007.Survival curves were plotted using the Kaplan-Meier method and compared using log-rank tests.Univariate and multivariate analyses were performed with the Cox proportional hazard model.Results Patients who received intra-operative systemic chemotherapy had higher 5-year overall survival and 5-year disease-free survival rates (P=0.019 and 0.010,respectively) than patients who did not receive intra-operative systemic chemotherapy.In the subgroup analysis,systemic intra-operative chemotherapy benefited the 5-year overall survival and disease-free survival rates for patients with cancer of stage pTNM ⅠB-ⅢB,but not stage pTNM ⅢC.Patients who received intra-operative systemic chemotherapy in combination with post-operative chemotherapy had higher 5-year overall survival and 5-year disease-free survival rates (P=0.046 and 0.021,respectively) than patients who only received postoperative chemotherapy.However,the difference in these rates between patients who received only intra-operative systemic chemotherapy and patients who only received curative surgery was not statistically significant (P=0.150 and 0.170,respectively).Multivariate analyses showed that intra-operative systemic chemotherapy was a favorable prognostic factor for the overall survival and disease-free survival rates (P =0.048 and 0.023,respectively).No grade 4 toxicities related to intra-operative systemic chemotherapy were recorded within the

  13. [Who has more anxiety concerning a shortened life span: terminal cancer patients or those in curative therapy?].

    Science.gov (United States)

    Bölter, Annette F; Lange, Julia; Anger, Bernd; Olbricht, Sigrid; Köhler, Michael; Frommer, Jörg

    2010-07-01

    The aim of this study is to investigate whether there is a difference in the amount of fear of the advancement (progression) and return (relapse) of cancer shown by terminal cancer patients and those in curative therapy. The cohort consists of 291 rehabilitation patients, main diagnoses were colonic/rectal-, breast- and prostate cancer. The patients were questioned using the fear of progression questionnaire (PA-F-KF) and a Five-Item Fear of Relapse/Recurrence Scale. Patients in palliative care and those in curative therapy are equally fearful of the disease progressing. When comparing both groups for fear of relapse however, those patients in palliative care are more anxious. This apparently paradoxical result can be seen as being an expression of the highly debilitating fear experienced by terminally ill cancer patients. Simultaneously, patients try to keep up their hope by unconsciously reinterpreting the actual progress of the disease as being a potential relapse. Georg Thieme Verlag KG Stuttgart-New York.

  14. Role of Hormonal Treatment in Prostate Cancer Patients with Nonmetastatic Disease Recurrence After Local Curative Treatment: A Systematic Review.

    Science.gov (United States)

    van den Bergh, Roderick C N; van Casteren, Niels J; van den Broeck, Thomas; Fordyce, Eve R; Gietzmann, William K M; Stewart, Fiona; MacLennan, Steven; Dabestani, Saeed; Bellmunt, Joaquim; Bolla, Michel; Briers, Erik; Cornford, Philip; Joniau, Steven; Mason, Malcolm D; Matveev, Vsevolod; van der Poel, Henk G; van der Kwast, Theo H; Rouvière, Olivier; Wiegel, Thomas; Lam, Thomas B; Mottet, Nicolas

    2016-05-01

    The relative benefits and harms of hormonal treatment (HT) versus no or deferred HT in patients with nonmetastatic prostate cancer (PCa) relapse after primary curative therapy are controversial. To assess the effectiveness of HT for nonmetastatic PCa relapse, prognostic factors for treatment outcome, timing of treatment, and the most effective treatment strategy to provide guidance for clinical practice. A systematic literature search was undertaken incorporating Medline, Embase, and the Cochrane Library (search ended March 2015). Studies were critically appraised for risk of bias. The outcomes included overall and cancer-specific survival, metastasis-free survival, symptom-free survival, progression to castrate resistance, adverse events, and quality of life. Of 9687 articles identified, 27 studies were eligible for inclusion (2 RCTs, 8 nonrandomised comparative studies, and 17 case series). The results suggest that only a subgroup of patients, especially those with high-risk disease, may benefit from early HT. The main predictors for unfavourable outcomes were shorter PSA doubling time (7). Early HT may be warranted for patients with high-risk disease. An intermittent HT strategy appears feasible. Most studies had a moderate to high risks of bias. HT for PCa relapse after primary therapy with curative intent should be reserved for patients at highest risk of progression and with a long life expectancy. The potential benefits of starting HT should be judiciously balanced against the associated harms. This article summarises the evidence on the benefits and harms of hormonal treatment in prostate cancer (PCa) patients in whom the disease has recurred following earlier curative treatment. We found that only a select group of patients with aggressive PCa and a fast rising prostate-specific antigen may benefit from early hormonal treatment (HT), whereas in others HT may be more harmful than beneficial. Copyright © 2015 European Association of Urology. Published by

  15. 那他霉素联合氟康唑治疗真菌性角膜炎的疗效评比%Curative Effect Comparation of Fungal Keratitis Treated with Natamycin and Fluconazole

    Institute of Scientific and Technical Information of China (English)

    祝彩英

    2015-01-01

    Objective:To study the curative effect of fungal keratitis treated with Natamycin and Fluconazole.Method:145 patients with fungal keratitis admitted in our hospital from April 2013 to August 2014 were selected,in accordance with the random number table they were randomly divided into the experimental group(n=75) and the control group(n=70),the control group was treated with Natamycin Eye Drops,the experimental group was treated with Natamycin combined with Fluconazole Eye Drops,the ulcer,pain,empyema and curative effect of two groups were observed and compared. Result:The total effective rate of the experimental group(80.00%) was significantly higher than that of the control group(52.86%),the difference had statistically significant(P<0.05).Conclusion:The curative effect of fungal keratitis treated with Natamycin and Fluconazole is more significantly than Natamycin alone,is suitable for clinical application for a long time.%目的:研究那他霉素联合氟康唑治疗真菌性角膜炎的疗效,探讨其临床适用性。方法:选取2013年4月-2014年8月在笔者所在医院就诊的145例真菌性角膜炎患者,按照随机数字表法分为试验组75例和对照组70例,对照组给予那他霉素滴眼液点眼,试验组给予氟康唑滴眼液和那他霉素滴眼液联合点眼,观察两组患者溃疡、疼痛、积脓等症状,评比其疗效。结果:试验组治疗总有效率(80.00%)明显高于对照组(52.86%),差异有统计学意义(P<0.05)。结论:那他霉素联合氟康唑治疗真菌性角膜炎疗效比单独使用那他霉素疗效更为显著,适合临床长期推广应用。

  16. [Impacts on the curative effect of peripheral facial paralysis treated with acupuncture and moxibustion at different times].

    Science.gov (United States)

    Feng, Lei; Ma, Wen-Zhu

    2013-12-01

    To explore the optimal intervention time of acupuncture and moxibustion in the treatment of peripheral facial paralysis. Two hundred and four cases of peripheral facial paralysis were collected in clinic for retrospective analysis. According to the time between the disease onset and the intervention of acupuncture and moxibustion, 3 groups (groups A, B and C) were divided. In group A, the treatment was given in 1 to 3 days after onset; in group B, the treatment was given in 4 to 7 days after onset; in group C the treatment was given in 8 to 10 days after onset. The treatment with acupuncture and moxibustion was applied according to the regular stages of disease in the three groups. At the acute stage, the less points and shallow puncture therapy combined with distal acupoints at the limbs were adopted on the affected side. At the stable stage, the more points and shallow puncture therapy were used on the affected side. At the recovery stage, the deep puncture or penetrating punctures was applied on the affected side. The curative effects was given once every day and the treatment of 10 days made one session. The curative effects were analyzed statistically at the end of three sessions of treatments separately. At the end of the 1st session of treatment, the total effective rate was 58.8% (40/68) in group A, 69.7% (53/76) in group B and 46.6% (28/60) in group C. At the end of the 2nd session of treatment, the total effective rate was 85.3% (58/68), 90.8% (69/76) and 71.6% (43/60) in group A, B and C separately. At the end of 3rd session of treatment, the total effective rates were 89.7% (61/68), 97.4% (74/76) and 83.3% (50/60) in the three groups separately. The differences were significant statistically at the same session of treatment among three groups (all Pacupuncture and moxibustion is in 4 to 7 days after onset of facial paralysis.

  17. Curative effect observation on combination therapy of Sihuangshuimi and ultrared radiation in treating mechanical phlebitis%四黄水蜜外敷与红外线治疗机械性静脉炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    欧艳凌; 冷蓉; 陈晓玲; 卢敏; 蔡带娣

    2014-01-01

    目的 观察中药四黄水蜜外敷联合神灯照射治疗PICC所致机械性静脉炎的临床疗效.方法 收集我院血液科2012年1月至2013年12月行PICC置管的患者共134例,对置管后出现不同程度的机械性静脉炎的21例患者使用中药四黄水蜜外敷联合红外线照射一个疗程后进行疗效观察.结果 21例发生机械性静脉炎患者经过一个疗程治疗后治愈率达到76.19%,无发生其它不良反应.结论 中药四黄水蜜外敷联合红外线照射能有效治疗血液肿瘤患者PICC所致机械性静脉炎.%Objective To observe the clinical curative effects of combination therapy of Sihuangshuimi and ultrared radiation in treating peripherally inserted central catheter (PICC)-caused-phlebitis.Methods We collected 134 patients admitted in hematology department of our hospital from January 2012 to December 2013,PICC-caused-phlebitis had happened in 21 of the total 134 cases,and they were treated with traditional Chinese medicine Sihuangshuimi external application plus radiation therapy as a course of treatment,then the curative effect was observed.Result After a course of treatment,21 cases (76.19%) was effective without any other adverse reactions.Conclusion The combination therapy of Sihuangshuimi and ultrared radiation is effective to PICC-caused-phlebitis in hematological malignancy patients.

  18. Patient-Specific Therapy via Cell-Reprogramming Technology: a Curative Potential for Patients with Diabetes

    Science.gov (United States)

    Luo, Haizhao; Wang, Xianbao; Zhang, Ruyi; Chen, Youping; Shu, Yi; Li, Huixian; Chen, Hong

    2015-12-01

    Gene therapeutics provides great opportunities for curing diabetes. Numerous attempts have been made to establish a safe and high-efficiency gene delivery strategy, but all of them are unsuccessful. To achieve an ideal transfection, a novel gene delivery strategy was presented in this research. The novel system proposed was transfection mediated by the combination of ultrasound with microbubbles and cross-linked polyethylenimines (PEIs). Ultrasound with microbubbles enhances the permeability of target cells; moreover, cross-linked PEIs enabled DNA to escape from endosomes into the cytoplasm. If the proposed method is feasible and effective, the endogenous secretion system of insulin would be re-established in patients with diabetes.

  19. Observation of the Curative Effect of Since the Quasi Square for Treating Dysmenorrhea%自拟方治疗痛经的疗效观察

    Institute of Scientific and Technical Information of China (English)

    刘海洋

    2015-01-01

    Objective To observe the curative ef ect for the treatment of dysmenorrhea. Methods From June 2010 to February 2010 in our hospital of traditional Chinese medicine outpatient treatment to patients with blood stasis type of dysmenor hea haemor heological nature of the treatment. Treatment according to the state administration of traditional Chinese medicine after the release of the evaluation of disease diagnosis curative ef ect of traditional Chinese medicine standard therapeutic ef ect. Results The cure 34 cases, 25 cases ef ectively, the total ef ective rate was 92.18%. Conclusion The proposed treatment of dysmenor hea high ef icient, worth clinical promotion.%目的:观察自拟方治疗痛经的疗效。方法对自2010年6月~2013年2月到我院中医门诊救治的寒凝血瘀型痛经患者行自拟方治疗。治疗结束后根据国家中医药管理局发布的《中医病症诊断疗效标准》评价治疗效果。结果治愈34例,有效25例,总有效率92.18%。结论自拟方治疗痛经有效率高,值得临床推广。

  20. Adequacy of Online Patient Information Resources on Gout and Potentially Curative Urate-Lowering Treatment.

    Science.gov (United States)

    Jimenez-Liñan, L M; Edwards, L; Abhishek, A; Doherty, Michael

    2017-05-01

    To assess the content and readability of online patient information resources against the current understanding of gout. An online survey was undertaken using Google UK, USA, Australia, and Canada. Information was assessed for content and accuracy on 19 key points regarding core content for gout patient information resources. Readability was assessed using the Flesch-Kincaid Reading Ease score. Fifteen randomly selected websites were reviewed by a blinded second observer. A total of 85 websites were selected. More than 50% of the websites provided no information or had inaccuracies regarding the pathogenesis of gout. Most websites contained information on dietary and lifestyle modifications for treating gout and did not emphasize urate-lowering therapy (ULT) and its potential for cure. Over 75% of the websites had no/inaccurate information on the role of ULT or prophylaxis for preventing gout attacks on starting ULT. The majority of websites were difficult to read, with information in 68% of the websites rated at least fairly difficult. Only a few web-based patient information resources provide accurate and easy-to-read information on gout. This study will help physicians direct patients to currently reliable resources, but there is a need to improve many web-based patient information resources, which at present act as barriers to care. © 2016, American College of Rheumatology.

  1. Diagnostic performance of FDG PET/CT for surveillance in asymptomatic gastric cancer patients after curative surgical resection

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Won [Catholic Kwandong University College of Medicine, Department of Nuclear Medicine, International St. Mary' s Hospital, Incheon (Korea, Republic of); Lee, Sang Mi [Soonchunhyang University Hospital, Department of Nuclear Medicine, 23-20 Byeongmyeong-dong, Dongnam-gu, Chungcheongnam-do, Cheonan (Korea, Republic of); Son, Myoung Won; Lee, Moon-Soo [Soonchunhyang University Hospital, Department of Surgery, Cheonan (Korea, Republic of)

    2016-05-15

    The present study evaluated the diagnostic performance of 2-[{sup 18}F] fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) for surveillance in asymptomatic gastric cancer patients after curative surgical resection. We retrospectively recruited 190 gastric cancer patients (115 early gastric cancer patients and 75 advanced gastric cancer patients) who underwent 1-year (91 patients) or 2-year (99 patients) postoperative FDG PET/CT surveillance, along with a routine follow-up program, after curative surgical resection. All enrolled patients were asymptomatic and showed no recurrence on follow-up examinations performed before PET/CT surveillance. All PET/CT images were visually assessed and all abnormal findings on follow-up examinations including FDG PET/CT were confirmed with histopathological diagnosis or clinical follow-up. During follow-up, 19 patients (10.0 %) developed recurrence. FDG PET/CT showed abnormal findings in 37 patients (19.5 %). Among them, 16 patients (8.4 %) were diagnosed as cancer recurrence. Of 153 patients without abnormal findings on PET/CT, three patients were false-negative and diagnosed as recurrence on other follow-up examinations. The sensitivity, specificity, positive predictive value, and negative predictive value of FDG PET/CT were 84.2 %, 87.7 %, 43.2 %, and 98.0 %, respectively. Among 115 early gastric cancer patients, PET/CT detected recurrence in four patients (3.5 %) and one patient with local recurrence. Among 75 advanced gastric cancer patients, PET/CT detected recurrence in 12 patients (16.0 %), excluding two patients experiencing peritoneal recurrence. In addition, FDG PET/CT detected secondary primary cancer in six (3.2 %) out of all the patients. Post-operative FDG PET/CT surveillance showed good diagnostic ability for detecting recurrence in gastric cancer patients. FDG PET/CT could be a useful follow-up modality for gastric cancer patients, especially those with advanced gastric cancer

  2. Curative effect comparison of two kinds of external use medicine for treating superficial scar%两种外用药物治疗浅表性瘢痕疗效比较

    Institute of Scientific and Technical Information of China (English)

    涂雪松; 彭友林; 胡友红

    2015-01-01

    Objective Observation of curative effect comparison of Compound Heparin Sodium and Allantoin Gel and MPS for treating superficial scar. Methods 44 superficial scar patients were randomly divided into 2 groups. The treatment group(A) of 22 cases were used Compound Heparin Sodium and Allantoin Gel. The control group(B) of 22 cases were used MPS cream.Then observed the curative effect of the two groups after 3 months. Results A group's total efficiency was 86.3%,and B was 63.6%.There were significant differences between two groups. Conclusion It has more effective to treat superficial scar with Compound Heparin Sodium and Allantoin Gel.%目的:观察比较复方肝素钠尿囊素凝胶和多磺酸粘多糖乳膏两种外用药物治疗浅表性瘢痕的疗效。方法:将44例浅表性瘢痕患者随机分为两组,治疗组(A组):22例,外用复方肝素钠尿囊素凝胶;对照组(B组):22例,外用多磺酸粘多糖乳膏。疗程均为3个月,疗程结束后观察疗效。结果:A组总效率86.3%,B组总效率63.6%,两组间总有效率比较有统计学差异(P<0.05)。结论:复方肝素钠尿囊素凝胶治疗浅表性瘢痕疗效更肯定。

  3. [Observation on curative effect of thermal acupuncture needle muscular stimulation therapy for knee osteoarthritis patients].

    Science.gov (United States)

    Yang, Xiao-Chu; He, Shao-Feng; Wang, Ren-Can; Zhou, Yong-Mei

    2012-06-01

    To observe the therapeutic effect of thermal acupuncture needle muscular stimulation for treatment of knee osteoarthritis patients. A total of 120 outpatients with knee osteoarthritis were randomly and equally divided into control and treatment groups. Patients of the treatment group were treated by inserting the acupuncture needles into the attached sites of the quadriceps femoris, musculus vastus medialis, vastus lateralis, etc. around the knee joint. The needles were manipulated repeately till "Deqi", followed by attaching a piece of ignited moxa-roll (about 2 cm length) to the needle handle. The treatment was conducted once a week, 4 weeks altogether. Patients of the control group were treated by oral administration of Celebrex (a specific inhibitor of COX-2, 200 mg/time, once daily, 4 weeks together). The therapeutic effect was evaluated by using visual analogue scale (VAS), Lequesne Index (Chinese Version) of osteoarthritis after 4 weeks' treatment and 3 months after the treatment. After 4 weeks' treatment and 3 months after the treatment, the effective rates were 78.3% (47/60) and 81.7% (49/60) in the control group, and 96.6% (58/60) and 96.6% (58/60) in the treatment group, respectively, being significantly higher in the treatment group (P<0.05). Both VAS scores and Lequesne Indexes in the treatment group, and VAS scores in the control group were decreased significantly after 4 weeks' treatment and 3 months' follow-up (P<0.05). The effects of the treatment group were considerably superior to those of the control group (P<0.05). Thermal needle muscular stimulation therapy is effective for relieving knee osteoarthritis patients' symptoms of pain, knee-joint stiffness, swelling, walking capability, etc.

  4. Curative Chemoradiotherapy in Patients With Stage IVB Cervical Cancer Presenting With Paraortic and Left Supraclavicular Lymph Node Metastases

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ji-Yoon [Department of Radiation Oncology, Catholic University of Korea, College of Medicine, Seoul (Korea, Republic of); Kim, Joo-Young [Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of); Kim, Jin Hee [Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu (Korea, Republic of); Yoon, Mee Sun [Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Jeollanam-do (Korea, Republic of); Kim, Juree [Department of Radiation Oncology, Cheil General Hospital and Women' s Healthcare Center, Kwandong University, College of Medicine, Seoul (Korea, Republic of); Kim, Young Seok, E-mail: ysk@amc.seoul.kr [Department of Radiation Oncology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul (Korea, Republic of)

    2012-11-01

    Purpose: To evaluate the efficacy and toxicity of concurrent chemoradiotherapy (CCRT) with curative intent in patients with stage IVB cervical cancer initially presenting with paraortic and left supraclavicular lymph node metastases. Methods and Materials: The medical records of 25 patients with both paraortic and left supraclavicular lymph nodal metastases (group I) were reviewed and compared with those of 101 women with paraortic lymph node metastases alone (group II). Group I received a mean 59.4 Gy to the paraortic and left supraclavicular areas and 50.4 Gy to the pelvis, followed by 30 Gy of high-dose-rate brachytherapy in 6 fractions. Group II received the same dose to the paraortic area and pelvis followed by intracavitary brachytherapy. All patients received platinum-based chemotherapy simultaneously. Results: Of the 25 patients in group I, 16 (64%) experienced acute grade 3-4 hematologic toxicities, and 1 had a late grade 3 genitourinary toxicity. Complete responses, including the primary mass and pelvic, paraortic, and left supraclavicular lymph nodes, were observed in 13 patients (52%). At a median follow-up of 32 months for surviving patients, 3 experienced in-field failure, 6 showed distant failure, and 9 showed both. The 3-year overall and disease-free survival rates were 49% and 33%, respectively. In comparison, of the 101 patients in group II, 16 showed in-field failure, 14 experienced distant failure, and 11 showed both. The 3-year overall and disease-free survival rates were 69% and 57%, respectively. Conclusions: Curative CCRT is feasible in patients with stage IVB cervical cancer presenting with paraortic and left supraclavicular lymph nodal metastases, with acceptable late toxicity and high response rates, despite high rates of acute hematologic toxicity.

  5. Curative chemoradiotherapy in patients with stage IVB cervical cancer presenting with paraortic and left supraclavicular lymph node metastases.

    Science.gov (United States)

    Kim, Ji-Yoon; Kim, Joo-Young; Kim, Jin Hee; Yoon, Mee Sun; Kim, Juree; Kim, Young Seok

    2012-11-01

    To evaluate the efficacy and toxicity of concurrent chemoradiotherapy (CCRT) with curative intent in patients with stage IVB cervical cancer initially presenting with paraortic and left supraclavicular lymph node metastases. The medical records of 25 patients with both paraortic and left supraclavicular lymph nodal metastases (group I) were reviewed and compared with those of 101 women with paraortic lymph node metastases alone (group II). Group I received a mean 59.4 Gy to the paraortic and left supraclavicular areas and 50.4 Gy to the pelvis, followed by 30 Gy of high-dose-rate brachytherapy in 6 fractions. Group II received the same dose to the paraortic area and pelvis followed by intracavitary brachytherapy. All patients received platinum-based chemotherapy simultaneously. Of the 25 patients in group I, 16 (64%) experienced acute grade 3-4 hematologic toxicities, and 1 had a late grade 3 genitourinary toxicity. Complete responses, including the primary mass and pelvic, paraortic, and left supraclavicular lymph nodes, were observed in 13 patients (52%). At a median follow-up of 32 months for surviving patients, 3 experienced in-field failure, 6 showed distant failure, and 9 showed both. The 3-year overall and disease-free survival rates were 49% and 33%, respectively. In comparison, of the 101 patients in group II, 16 showed in-field failure, 14 experienced distant failure, and 11 showed both. The 3-year overall and disease-free survival rates were 69% and 57%, respectively. Curative CCRT is feasible in patients with stage IVB cervical cancer presenting with paraortic and left supraclavicular lymph nodal metastases, with acceptable late toxicity and high response rates, despite high rates of acute hematologic toxicity. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. 溃疡性结肠炎灌肠液治疗溃疡性结肠炎的临床疗效观察%Observation on Clinical Curative Effect of Kuijie Enema in Treating Ulcerative Colitis

    Institute of Scientific and Technical Information of China (English)

    任毅; 文华; 张振忠; 赵洪波; 马树梅; 李远; 梁斌强; 刘宁州; 豆小妮; 万照良

    2013-01-01

    Objective:To observe the clinical curative effects of Chinese herbal medicine enema in treating ulcerative colitis .Methods:Sixty patients with ulcerative colitis were given the treatment of self-made enema .They were given the detection of serum cytokines ,such as IL-1 β,TNF-αand Nos-3/eNos to observe the clinical curative effects of the Chinese herbal medicine enema on ulcerative colitis . Results:After a course of treatment,the total effective rate was 93.33%.The level of IL-1βwas promoted by 19.7% on average,and the level of TNF-αwas reduced by an average of 14.7%.The level of Nos-3/e Nos was decreased by 20.8%.Conclusion:In the treat-ment of UC ,Chinese medicine Kuijie enema shows the advantages of reliable curative effect ,easy application ,and low cost ,which is worth of clinical application .%目的:观察中草药灌肠对溃疡性结肠炎的临床疗效。方法:将60例溃疡性结肠炎患者给予自拟灌肠液治疗,检测血清细胞因子水平白介素1β( Interleukin-1β,IL-1β)、肿瘤坏死因子( Tumor Necrosis Factor -α,TNF-α)、一氧化氮合酶-3(内皮型)( Nitric Oxide Synthase-3,Nos-3/eNos)的变化趋势以观察中草药液灌肠对溃疡性结肠炎的临床疗效。结果:治疗1个疗程后,总有效率达93.33%,IL-1β平均提升了19.7%,TNF-α平均降低了14.7%,Nos-3/eNos平均降低了20.8%。结论:溃疡性结肠炎灌肠液在防治溃疡性结肠炎方面,疗效可靠,使用方便,造价低廉,值得临床推广。

  7. 至灵胶囊配合天王补心丸治疗阴血亏虚型失眠症80例疗效观察%Curative effect observation of zhiling capsules combined with tianwangbuxin pills treating 80 cases with defi-ciency of Yin-blood type of insomnia

    Institute of Scientific and Technical Information of China (English)

    薛峰; 李坤

    2016-01-01

    目的:探讨至灵胶囊配合天王补心丸治疗阴血亏虚型失眠症的疗效。方法:收治阴血亏虚型失眠症患者80例,给予至灵胶囊配合天王补心丸治疗,观察患者疗效。结果:痊愈率27.05%,显效率34.12%,总有效率83.52%。结论:至灵胶囊配合天王补心丸治疗阴血亏虚型失眠症治疗效果良好。%Objective:To evaluate the clinical curative effect of zhiling capsules combined with tianwangbuxin pills treating deficiency of Yin-blood type of insomnia.Methods:80 cases of patients with deficiency of Yin-blood type of insomnia were treated with zhiling capsules combined with tianwangbuxin pills and the clinical curative effect of patients was observed.Results:The cure rate was 27.05%,the excellent effective rate was 34.12%,and the total effective rate was 83.52%.Conclusion:Zhiling capsules combined with tianwangbuxin pills treating deficiency of Yin-blood type of insomnia had good clinical curative effect.

  8. Multi-Institutional Analysis of Solitary Extramedullary Plasmacytoma of the Head and Neck Treated With Curative Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Sasaki, Ryohei, E-mail: rsasaki@med.kobe-u.ac.jp [Division of Radiation Oncology, Kobe University Graduate School of Medicine (Japan); Yasuda, Koichi [Department of Radiology, Hokkaido University School of Medicine (Japan); Abe, Eisuke [Division of Radiation Oncology, Graduate School of Medical and Dental Sciences, Niigata University (Japan); Uchida, Nobue [Department of Radiation Oncology, Shimane University Faculty of Medicine (Japan); Kawashima, Mitsuhiko [Radiation Oncology Division, National Cancer Center Hospital East (Japan); Uno, Takashi [Department of Radiology, Graduate School of Medicine, Chiba University (Japan); Fujiwara, Masayuki [Department of Radiology, Hyogo College of Medicine (Japan); Shioyama, Yoshiyuki [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University (Japan); Kagami, Yoshikazu [Radiation Oncology Division, National Cancer Center Hospital (Japan); Shibamoto, Yuta [Department of Radiology, Nagoya City University Graduate School of Medical Sciences (Japan); Nakata, Kensei [Department of Radiology, Sapporo Medical University (Japan); Takada, Yoshie [Department of Radiology, Osaka City University Graduate School of Medicine (Japan); Kawabe, Tetsuya; Uehara, Kazuyuki [Division of Radiation Oncology, Kobe University Graduate School of Medicine (Japan); Nibu, Kenichi [Division of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine (Japan); Yamada, Syogo [Department of Radiation Oncology, Tohoku University School of Medicine (Japan)

    2012-02-01

    Purpose: The purpose of this study was to elucidate the efficacy and optimal method of radiotherapy in the management of solitary extramedullary plasmacytoma occurring in the head and neck regions (EMPHN). Methods and Materials: Sixty-seven patients (43 male and 24 female) diagnosed with EMPHN between 1983 and 2008 at 23 Japanese institutions were reviewed. The median patient age was 64 years (range, 12-83). The median dose administered was 50 Gy (range, 30-64 Gy). Survival data were calculated by the Kaplan-Meier method. Results: The median follow-up duration was 63 months. Major tumor sites were nasal or paranasal cavities in 36 (54%) patients, oropharynx or nasopharynx in 16 (23%) patients, orbita in 6 (9%) patients, and larynx in 3 (5%) patients. The 5- and 10-year local control rates were 95% and 87%, whereas the 5- and 10-year disease-free survival rates were 56% and 54%, respectively. There were 5 (7.5%), 12 (18%), and 8 (12%) patients who experienced local failure, distant metastasis, and progression to multiple myeloma, respectively. In total, 18 patients died, including 10 (15%) patients who died due to complications from EMPHN. The 5- and 10-year overall survival (OS) rates were 73% and 56%, respectively. Radiotherapy combined with surgery was identified as the lone significant prognostic factor for OS (p = 0.04), whereas age, gender, radiation dose, tumor size, and chemotherapy were not predictive. No patient experienced any severe acute morbidity. Conclusions: Radiotherapy was quite effective and safe for patients with EMPHN. Radiotherapy combined with surgery produced a better outcome according to survival rates. These findings require confirmation by further studies with larger numbers of patients with EMPHN.

  9. Hypoacusia in a Patient Treated by Isotretinoin

    Directory of Open Access Journals (Sweden)

    L. Rosende

    2011-01-01

    Full Text Available Isotretinoin is the most effective treatment for severe acne, but there are several adverse effects associated with its use, some of them very exceptional (<1/10000. We report one case of hypoacusia and tinnitus in a 15-year-old boy treated with isotretinoin during 6 weeks, who quickly improved after isotretinoin withdrawal. Also, we comment other publications about hearing alterations in patients treated with isotretinoin and other retinoids.

  10. Observations on the Curative Effect of Acupuncture on Depressive Neurosis

    Institute of Scientific and Technical Information of China (English)

    FU Wen-bin; WANG Si-you

    2003-01-01

    Purpose To evaluate the curative effect of acupuncture on depressive neurosis. Method Sixty-two patients were randomly divided into a treatment group of 32 cases and a control group of 30 cases. The treatment group and the control group were treated with acupuncture and Fluoxetine, respectively. The curative effects were evaluated by HAMD. Results There was a significant difference between pretreatment and posttreatmentin each group ( P 0.05). But acupuncture had no side effects and was good in compliance. Conclusion Acupuncture is an effective method for treating depressive neurosis.

  11. 微创治疗细菌性肝脓肿的疗效分析%Curative Effects of Minimally Invasive Therapy in Treating Pyogenic Liver Abscess

    Institute of Scientific and Technical Information of China (English)

    于亮; 段绍斌; 刘郁; 杨东鹰; 居来提; 邓明飞; 陈骏

    2011-01-01

    目的 探讨细菌性肝脓肿腹腔镜切开引流术和经皮穿刺引流术的适应证及疗效.方法 对外科处理的83例肝脓肿患者的临床资料进行回顾性分析,比较细菌性肝脓肿腹腔镜切开引流术与经皮穿刺引流术的疗效.结果 两组患者年龄、性别、脓肿大小、数量、病程、术前白细胞计数、清蛋白、空腹血糖水平比较,差异均无统计学意义(P>0.05).腹腔镜组手术时间较穿刺引流组明显延长,差异有统计学意义(P<0.05);两组体温恢复正常时间比较,差异无统计学意义(P>0.05);腹腔镜组白细胞恢复时间及住院时间较穿刺引流组明显缩短,差异有统计学意义(P<0.05);腹腔镜组较穿刺引流组治愈率明显升高,复发率明显降低,差异均有统计学意义(P<0.05).两组患者经治疗后均无大出血、腹膜炎、腹腔脏器损伤、胆瘘等严重并发症发生.结论 腹腔镜肝脓肿切开引流术和经皮肝脓肿穿刺引流术均是微创治疗细菌性肝脓肿的有效手段,前者操作更加简单安全,后者治疗更彻底.把握二者的适应证尤其重要.%Objective To explore the indications and curative effects of laparoscopic drainage and percutaneous transhepatic drainage in treating pyogenic liver abscess. Methods Data from 83 patients with pyogenic liver abscess after surgical manipulation were analyzed retrospectively, and the outcomes of laparoscopic drainage were compared with those of percutaneous transhepatic drainage. Results No significant differences were noted when age, gender, size of abscess, quantity of abscess,course of disease, preoperative lencocyte count, albumin level and fasting blood sugar level were compared between the two groups ( P > 0.05 ) . Operating time of the laparoscopic drainage group was notably longer than the percutaneous transhepatic drainage group with statistically significant difference ( P<0.05 ) . Time of body temperature restoration was not

  12. 恩再适注射液肌注治疗LDH术后残余神经痛的临床疗效观察%Observation on Clinical Curative Effect of Analgecine Muscle Injection Treating Postoperative Residual Neuralgia of LDH

    Institute of Scientific and Technical Information of China (English)

    徐昆; 郝佳颖; 肖天洁; 杜元良; 孙贺; 张义龙; 赵艳军; 张峥

    2016-01-01

    Objective:To observe the clinical curative effect of analgecine muscle injection treating postoper-ative residual neuralgia of LDH ( protrusion of lumbar intervertebral disc ) . Methods: 90 LDH patients be-tween 40 and 59 years old who were insensitive to regular conservative treatment ( four weeks) , with VAS 5 points,and still sufferedfrom lower limb pain or ( and) numb at the 2nd week after waist 4-5 or waist 5-sa-crum 1 nucleus pulposus removal and intervertebral fusion. They were randomized into three groups, with 30 cases in each group:group A ( VitaminB1+B12Injectiongroup) , group B ( Cobamamide injection group) , and group C ( analgecine injection group) . After being treated for 3-6 weeks by the listed three treatment meth-ods, the clinical curative effect of analgecine injection treating postoperative residual neuralgia of LDH were observed. Result:the clinical curative effect of group C ( analgecine injection group) was significantly better than that of group A and group B. Conclusions:analgecine injection can significantly improve the postoperative residualneuralgia of LDH and it has a significant clinical curative effect.%目的::观察恩再适注射液肌注治疗LDH(腰椎间盘突出症)术后残余神经痛的临床疗效。方法:选择年龄于40~59岁之间的LDH患者90例(男女各45例)经正规保守治疗4周无效且VAS≥5分患者,行腰4-5或腰5-骶1髓核摘除、椎间融合术后第2周仍存在下肢疼痛或(和)麻木者,按照完全随机等分法分三组、每组30例:A组(维生素B1+B12注射液组),B组(注射用腺苷钴胺组),C组(恩再适注射液组),通过上述三组治疗3~6周后,观察恩再适注射液组治疗LDH术后残余神经痛的临床疗效。结果:C组(恩再适注射液组)临床疗效显著优于A、B两组。结论:恩再适注射液可显著改善LDH术后残余神经痛症状,具有显著临床疗效。

  13. [The study of the pure tone audiometry characteristics and curative effect in sudden hearing loss patients with hypertension].

    Science.gov (United States)

    Li, Qian; Wang, Dayong; Wang, Hongyang; Lan, Lan; Han, Bing; Qi, Yue; Guan, Jing; Yin, Zifang; Wu, Ziming; Wang, Qiuju

    2014-04-01

    To investigate the pure tone audiometry characteristics and curative effect in sudden hearing loss patients with hypertension. One hundred and fifty-seven inpatients (168 ears) with hypertension suffered from sudden hearing loss were included in this study. We retrospectively analyzed the audiological index of these patients by comparing the pure tone audiometry (PTA) among patients in the aspects of gender, age, affected side, duration of hypertension, with or without inducement, concomitant symptoms and other combined diseases. The hearing threshold at different frequency was also compared, as well as the curative effect among patients with diverse audiological characteristics. Of the contemporaneous sudden hearing loss patients (874 cases), the prevalence of hypertension was 17.96%, where the male ones accounted for. 28.69% (103/359) and the female ones accounted for 19.42% (54/278) respectively with statistically significant difference between genders (P hearing threshold in PTA were increasingly severe as the increasing impaired-frequency, and the difference of the degree of hearing impairment among these three types of frequencies was statistically significant (P hearing threshold means of each frequency had no significant difference among patients with various gender, age and Cardiovascular Risk Stratification (P > 0.05). The hearing threshold means of each frequency of unilateral hearing loss patients was significantly higher than that of bilateral hearing loss patients (P hearing threshold means at 125 Hz, 250 Hz, 500 Hz and 1 kHz showed significant difference among patients with different duration of hypertension (P sudden hearing loss in patients with hypertension was significantly lower than that in the sudden hearing loss patients without hypertension (19.64%, 61.57% respectively, P sudden hearing loss in hypertension patients was higher in male than in female, which rose with age and combined disease. The hearing threshold means at mid-frequency and

  14. [A Case of Advanced Transverse Colon Cancer with Nephrotic Syndrome Treated with Curative Resection and Complete Adjuvant Chemotherapy].

    Science.gov (United States)

    Sato, Nobutaka; Fuyuno, Seiya; Hatada, Teppei; Furuhashi, Takashi; Abe, Toshihiko

    2017-05-01

    A 74-year-old woman was diagnosed as having transverse colon cancer after diagnosis of nephrotic syndrome caused by membranous nephropathy. Although she had hypoproteinemia and hypoalbuminemia, we judged that she had no major nutritional problem. In previous, similar case reports, the use of human serum albumin and fresh-frozen plasma was suggested to be important to avoid complications in the perioperative period. Thus, we used the same in our patient in the perioperative period. In addition, we paid special attention to perioperative nutrition management and used total parenteral nutrition in perioperative period. We performed laparoscopic assisted right hemicolectomy. On the 15th day after the surgical resection, the patient was discharged without any problems. We considered that postoperative adjuvant chemotherapy with XELOX (CapeOX)should be performed because the TNM pathological stage was pStage III b. Regarding adjuvant chemotherapy for gastrointestinal cancer with nephrotic syndrome, no previous reports detailed the indications for postoperative adjuvant chemotherapy. Upon introduction of adjuvant chemotherapy, we determined adaptation in accordance with the general adaptation criteria. While observing the patient's progress with a nephrologist, we safely completed the scheduled 8 courses adjuvant chemotherapy.

  15. A time-saving but effective approach to the follow-up of patients after curative surgery for carcinoma of the large bowel

    OpenAIRE

    Ross

    1983-01-01

    The traditional methods of follow-up of patients after curative surgery for large-bowel carcinoma have been shown to be time-consuming but largely ineffectual. A new approach is proposed which utilises laboratory investigations. A plea is made for controlled trials of cytotoxic regimens in patients with proven recurrent disease.

  16. Ipsilateral pleural recurrence after diagnostic transthoracic needle biopsy in pathological stage I lung cancer patients who underwent curative resection.

    Science.gov (United States)

    Moon, Seong Mi; Lee, Dae Geun; Hwang, Na Young; Ahn, Soohyun; Lee, Hyun; Jeong, Byeong-Ho; Choi, Yong Soo; Shim, Young Mog; Kim, Tae Jeong; Lee, Kyung Soo; Kim, Hojoong; Kwon, O Jung; Lee, Kyung Jong

    2017-09-01

    The relationship between transthoracic needle biopsy (TTNB) and pleural recurrence of cancer after curative lung resection remains unclear. We aimed to assess whether TTNB increases the ipsilateral pleural recurrence (IPR) rate and identify other potential risk factors for pleural recurrence after surgery. This retrospective study included 392 patients with p-stage I non-small cell lung cancer with solid or part-solid nodules after curative lung resection in 2009-2010. Imbalances among the characteristics were adjusted using an inverse probability-weighted method based on propensity scoring. Multivariate Cox's regression analysis and the Kaplan-Meier method were used to determine independent risk factors for IPR. A total of 243 (62%) patients received TTNB, while 149 (38%) underwent an alternate, or no, diagnostic technique. IPR was significantly more frequent in the TTNB group (p=0.004), while total recurrence was similar between the groups (p=0.098). After applying the weighted model, diagnostic TTNB (hazard ratio [HR], 5.27; 95% confidence interval [CI], 1.49-18.69; p=0.010), microscopic visceral pleural invasion (HR, 2.76; 95% CI, 1.08-7.01; p=0.033) and microscopic lymphatic invasion (HR, 3.25; 95% CI, 1.30-8.10; p=0.012) were associated with an increased frequency of IPR. Among patients who received TTNB, microscopic lymphatic invasion was a risk factor for IPR (HR, 2.74; 95% CI, 1.10-6.79; p=0.030). The diagnostic TTNB procedure is associated with pleural recurrence but may be unrelated to overall recurrence-free survival in early lung cancer. Moreover, microscopic lymphatic invasion could be a risk factor for pleural recurrence. TTNB should be carefully considered before lung resection and close follow-up to detect if pleural recurrence is needed. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Sarcopenia predicts 1-year mortality in elderly patients undergoing curative gastrectomy for gastric cancer: a prospective study.

    Science.gov (United States)

    Huang, Dong-Dong; Chen, Xiao-Xi; Chen, Xi-Yi; Wang, Su-Lin; Shen, Xian; Chen, Xiao-Lei; Yu, Zhen; Zhuang, Cheng-Le

    2016-11-01

    One-year mortality is vital for elderly oncologic patients undergoing surgery. Recent studies have demonstrated that sarcopenia can predict outcomes after major abdominal surgeries, but the association of sarcopenia and 1-year mortality has never been investigated in a prospective study. We conducted a prospective study of elderly patients (≥65 years) who underwent curative gastrectomy for gastric cancer from July 2014 to July 2015. Sarcopenia was determined by the measurements of muscle mass, handgrip strength, and gait speed. Univariate and multivariate analyses were used to identify the risk factors associated with 1-year mortality. A total of 173 patients were included, in which 52 (30.1 %) patients were identified as having sarcopenia. Twenty-four (13.9 %) patients died within 1 year of surgery. Multivariate analysis showed that sarcopenia was an independent risk factor for 1-year mortality. Area under the receiver operating characteristic curve demonstrated an increased predictive power for 1-year mortality with the inclusion of sarcopenia, from 0.835 to 0.868. Solely low muscle mass was not predictive of 1-year mortality in the multivariate analysis. Sarcopenia is predictive of 1-year mortality in elderly patients undergoing gastric cancer surgery. The measurement of muscle function is important for sarcopenia as a preoperative assessment tool.

  18. Life Expectancy in Patients Treated for Osteoporosis

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Osmond, Clive; Cooper, Cyrus

    2015-01-01

    Osteoporosis is a chronic disease, carrying an elevated risk of fractures, morbidity, and death. Long-term treatment may be required, but the long-term risks with osteoporosis drugs remain incompletely understood. The competing risk of death may be a barrier to treating the oldest, yet this may...... not be rational if the risk of death is reduced by treatment. It is difficult to devise goal-directed long-term strategies for managing osteoporosis without firm information about residual life expectancy in treated patients. We conducted an observational study in Danish national registries tracking prescriptions...... for osteoporosis drugs, comorbid conditions, and deaths. We included 58,637 patients and 225,084 age- and sex-matched control subjects. Information on deaths until the end of 2013 was retrieved, providing a follow-up period of 10 to 17 years. In men younger than 80 years and women younger than 60 years...

  19. A curated collection of tissue microarray images and clinical outcome data of prostate cancer patients

    Science.gov (United States)

    Zhong, Qing; Guo, Tiannan; Rechsteiner, Markus; Rüschoff, Jan H.; Rupp, Niels; Fankhauser, Christian; Saba, Karim; Mortezavi, Ashkan; Poyet, Cédric; Hermanns, Thomas; Zhu, Yi; Moch, Holger; Aebersold, Ruedi; Wild, Peter J.

    2017-01-01

    Microscopy image data of human cancers provide detailed phenotypes of spatially and morphologically intact tissues at single-cell resolution, thus complementing large-scale molecular analyses, e.g., next generation sequencing or proteomic profiling. Here we describe a high-resolution tissue microarray (TMA) image dataset from a cohort of 71 prostate tissue samples, which was hybridized with bright-field dual colour chromogenic and silver in situ hybridization probes for the tumour suppressor gene PTEN. These tissue samples were digitized and supplemented with expert annotations, clinical information, statistical models of PTEN genetic status, and computer source codes. For validation, we constructed an additional TMA dataset for 424 prostate tissues, hybridized with FISH probes for PTEN, and performed survival analysis on a subset of 339 radical prostatectomy specimens with overall, disease-specific and recurrence-free survival (maximum 167 months). For application, we further produced 6,036 image patches derived from two whole slides. Our curated collection of prostate cancer data sets provides reuse potential for both biomedical and computational studies. PMID:28291248

  20. A curated collection of tissue microarray images and clinical outcome data of prostate cancer patients.

    Science.gov (United States)

    Zhong, Qing; Guo, Tiannan; Rechsteiner, Markus; Rüschoff, Jan H; Rupp, Niels; Fankhauser, Christian; Saba, Karim; Mortezavi, Ashkan; Poyet, Cédric; Hermanns, Thomas; Zhu, Yi; Moch, Holger; Aebersold, Ruedi; Wild, Peter J

    2017-03-14

    Microscopy image data of human cancers provide detailed phenotypes of spatially and morphologically intact tissues at single-cell resolution, thus complementing large-scale molecular analyses, e.g., next generation sequencing or proteomic profiling. Here we describe a high-resolution tissue microarray (TMA) image dataset from a cohort of 71 prostate tissue samples, which was hybridized with bright-field dual colour chromogenic and silver in situ hybridization probes for the tumour suppressor gene PTEN. These tissue samples were digitized and supplemented with expert annotations, clinical information, statistical models of PTEN genetic status, and computer source codes. For validation, we constructed an additional TMA dataset for 424 prostate tissues, hybridized with FISH probes for PTEN, and performed survival analysis on a subset of 339 radical prostatectomy specimens with overall, disease-specific and recurrence-free survival (maximum 167 months). For application, we further produced 6,036 image patches derived from two whole slides. Our curated collection of prostate cancer data sets provides reuse potential for both biomedical and computational studies.

  1. Curative Effect Observation in Treating 113 Cases of Ance Vulgaris with Chinese Medical Facial Mask Combined Therapy%中药面膜综合疗法治疗113例寻常痤疮疗效观察

    Institute of Scientific and Technical Information of China (English)

    曾雪; 张晓红; 沈冬; 丁旭; 华华; 闫雨荷; 王煜明; 乔丽; 陈弘平; 刘瓦利; 赵婷; 赵俊英; 瞿幸; 徐志莉; 田野; 崔炳南; 吴小红

    2011-01-01

    Objective To evaluate the curative effect of Chinese Medical Facial Mask combined therapy in treating lesions of different degrees of ance vulgaris. Methods A total of 233 enrolled patients were divided randomly into two groups respectively, which had treated with external application of Chinese Medical Facial Mask combined therapy twice a week for four weeks and 5% benzoly peroxide gel( Benzihex) once a night for four weeks,without any oral medicine. After the therapy had been finished,the integral changes in different types of lesions were evaluated. Results After 4 weeks therpy, the effective rate of treating types, quantities, colours, swelling of lesion in Chinese Medical Facial Mask combined therapy were respectively 61.06% and 61.06% ,73.45% ,74.77% in contrast to 46.67% ,46.67% ,58.33% and 59.13% of western medicine in order. There were significant differences of curative effect in terms of each types of lesions between the two groups(P<0.05). Chinese Medical Facial Mask combined therapy can degrade the grade of severity in lesions of different degrees. Conclusion Chinese Medical Facial Mask combined therapy has significantly curative effect on treating lesions of different degrees of ance vulgaris.%目的 评价中药面膜综合疗法治疗寻常痤疮的疗效.方法 将入选的233例痤疮患者随机分为2组,分别予中药面膜综合疗法治疗(2次/周)和5%过氧化苯甲酰凝胶(每晚1次)治疗,两组疗程均为4周,疗程结束后按照不同标准分别判定疗效.结果 治疗4周后,治疗组按皮损类型、数量、颜色、肿胀程度分类评价的治疗有效率分别是61.06%、61.06%、73.45%和74.77%,对照组是46.67%、46.67%、58.33%、59.13%,两组间不同程度皮损疗效相比差异有统计学意义(P<0.05);中药面膜综合疗法能降低各项皮损严重程度分级.结论 中药面膜综合疗法治疗Ⅰ~Ⅲ度寻常痤疮疗效明显.

  2. Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study

    DEFF Research Database (Denmark)

    Mazeron, Renaud; Fokdal, Lars U; Kirchheiner, Kathrin

    2016-01-01

    Purpose To establish dose volume–effect relationships predicting late rectal morbidity in cervix cancer patients treated with concomitant chemoradiation and MRI-guided adaptive brachytherapy (IBABT) within the prospective EMBRACE study. Material and method All patients were treated with curative ...

  3. Curative Effect Observation of Treating 17 Cases of Gastric Bezoar Department of Internal Medicine%17例胃石症内科治疗效果观察

    Institute of Scientific and Technical Information of China (English)

    曹月敏; 王琳; 吴淑彦

    2014-01-01

    目的:内科保守治疗胃石的疗效观察。方法选择我院2011年~2013年17例胃石患者(均为植物性胃石)口服口服多潘立酮10mg,3次/d,兰索拉唑30mg,1次/d,碳酸氢钠注射液20ml,4次/d,可口可乐150ml,6次/d,共用7d。结果14例患者结石消失,3例患者胃石变小,在胃镜下应用圈套器碎石治疗,治疗过程中,2例患者出现腹胀,恶心症状,无消化道出血及穿孔发生。结论内科保守治疗胃石患者痛苦小、费用较低,效果明显、值得推广。%Objective To observe the curative ef ect of conservative treatment of gastrolith Department of internal medicine. Methods Our hospital in the years 2011~2013 17 cases of gastrolith patients (al vegetable gastrolithiasis) oral domperidone 10 mg 3 times daily, lansoprazole 30 mg once daily, Sodium Bicarbonate Injection 20 ml, 4 times a day, Coca-Cola 150 mil iliters 6 times a day, a total of 7 days. Results 14 patients with gal stone disappeared, 3 cases gastric bezoar smal er, application of the snare lithotripsy under the endoscopy, the course of treatment, 2 patients with abdominal distention, nausea, no gastrointestinal hemorrhage and perforation. Conclusion Department of internal medicine, conservative treatment of bezoar pain in patients with small, low cost, obvious ef ect, worthy of promotion.

  4. Patient safety risks and patients treated by multiple specialties.

    NARCIS (Netherlands)

    Baines, R.; Bruijne, M. de; Langelaan, M.; Wagner, C.

    2013-01-01

    Objectives: To determine if the number of medical specialties treating a patient is associated with the risk of experiencing harm during hospital admission. Methods: We performed structured retrospective patient record review study by trained nurses and physicians. We included 20 hospitals in the N

  5. The observation of Tiapride curative effect on 60 mental disorder patients with anxiety and dyssomnia%泰必利治疗神经症患者焦虑及睡眠障碍 60例疗效观察

    Institute of Scientific and Technical Information of China (English)

    李文华; 苏建宁; 龚劭工

    2001-01-01

    @@Background:Tiapride is a kind of derivative with thiamphenicol and o- dianisidine. It mainly acts on mesencephalon limbic system, blocks dopamine receptor selectively, it also has antagonism on corpus striatum dopamine somatic abnormal. Thus the patients are made tranquilizer, calm and pain relieved. Generally it has a certain curative effect on mental disorder people. Objective:To discuss the curative effect of mental disorder people, and to find on which symptom it has the best curative effect.

  6. Evaluation of the best follow-up period and curative effect for acoustic neuroma treated with a gamma knife%听神经瘤伽玛刀治疗后最佳随访时间的探讨

    Institute of Scientific and Technical Information of China (English)

    Xi Li; Yinhui Deng; Zhongjun Hou; Yaotang Chen; Yong He; Xiaojun Yu

    2008-01-01

    Objective:To determine the best follow-up period with regard to curative effect for acoustic neuroma treated with a gamma knife.Methods:Sixty cases of acoustic neuroma were treated with a gamma knife.The follow-up period was from 3 to 102 months.Changes in the lesions and peripheral tissues and clinical symptoms were compared and the curative effectiveness of gamma knife treatment was evaluated.Results:The highest total effective rate (92.3%) was in the third period.There was a significant difference in the tumor size postoperatively.There was no edema in the peripheral tissues surrounding the tumor.It was not obvious that clinical symptoms changed.Conclusion:In this report,the best follow-up period was 24-36months.Gamma knife treatment was still effective after 60 months post-operation.

  7. Nursing of advanced colorectal cancer patients treated with Cetuximab combined with chemotherapy

    Institute of Scientific and Technical Information of China (English)

    Xiaoping Zhu; Chunli Wu

    2008-01-01

    Cetuximab is a new medication that has recently been approved for the treatment of advanced colorectal cancer. To date we have had tittle experience in using this targeted agent. Eleven patients in our hospital with advanced colorectal cancer were treated with cetuximab and chemotherapy. Based on the curative effect of this combination therapy, we have concluded that the following nursing practices make an important contribution to the patients' prognosis and wellbeing: to establish a good nurse-patient relationship, to increase patient understanding of the side effects, to standardize the medications, to observe and to deal with the side effects of the medications(for example skin reaction, neutropenia, and diarrhea), and to provide continuous mental health care support and education.

  8. Establishment and Validation of SSCLIP Scoring System to Estimate Survival in Hepatocellular Carcinoma Patients Who Received Curative Liver Resection.

    Directory of Open Access Journals (Sweden)

    Sha Huang

    Full Text Available There is no prognostic model that is reliable and practical for patients who have received curative liver resection (CLR for hepatocellular carcinoma (HCC. This study aimed to establish and validate a Surgery-Specific Cancer of the Liver Italian Program (SSCLIP scoring system for those patients.668 eligible patients who underwent CLR for HCC from five separate tertiary hospitals were selected. The SSCLIP was constructed from a training cohort by adding independent predictors that were identified by Cox proportional hazards regression analyses to the original Cancer of the Liver Italian Program (CLIP. The prognostic performance of the SSCLIP at 12 and 36-months was compared with data from existing models. The patient survival distributions at different risk levels of the SSCLIP were also assessed.Four independent predictors were added to construct the SSCLIP, including age (HR = 1.075, 95%CI: 1.019-1.135, P = 0.009, albumin (HR = 0.804, 95%CI: 0.681-0.950, P = 0.011, prothrombin time activity (HR = 0.856, 95%CI: 0.751-0.975, P = 0.020 and microvascular invasion (HR = 19.852, 95%CI: 2.203-178.917, P = 0.008. In both training and validation cohorts, 12-month and 36-month prognostic performance of the SSCLIP were significantly better than those of the original CLIP, model of end-stage liver disease-based CLIP, Okuda and Child-Turcotte-Pugh score (all P < 0.05. The stratification of risk levels of the SSCLIP showed an enhanced ability to differentiate patients with different outcomes.A novel SSCLIP to predict survival of HCC patients who received CLR based on objective parameters may provide a refined, useful prognosis algorithm.

  9. Curative Result with Primary Medical Therapy in an Elderly Acromegaly Patient

    OpenAIRE

    Cander, Soner; Oz Gul, Ozen; Ersoy, Canan; Erturk, Erdinc

    2015-01-01

    AbstractIn acromegaly, transsphenoidal hypophysectomy is the primary treatment of choice. Medical treatment is performed on patients uncontrollable with surgery. Indications for primary medical treatment or medical treatment prior to surgery are limited to patients with macroadenoma with high risk for surgery due to cardiac and respiratory problems. Medical treatment is not applied on patients with microadenoma due to the high chance of cure with surgical option. Seventy-five years-old female...

  10. Curative Effects of Sacral Injection Therapy Plus Massage in Treating Acute Lumbar Sprain%骶管注射联合推拿疗法治疗急性腰扭伤的疗效研究

    Institute of Scientific and Technical Information of China (English)

    温优良; 何萃; 陈先武; 张大丁

    2012-01-01

    Objective To explore the curative effects of sacral injection plus strong stimulation massage on tender points in treating acute lumbar sprain. Methods 120 patients diagnosed with acute lumbar sprain and treated from January 2010 to May 2011 in the Department of Rehabilitation Medicine, Guangdong No. 2 Provincial People's Hospital were enrolled in the study, all the patients being informed and having agreed on the treating plan. They were randomly divided into four groups: sacral injection therapy ( SIT ) group, strong stimulation massage tender points ( SSMTP ) group, physiotherapy group and integrated group with 30 patients in each group. Patients in the SIT group received injection of 20 mi's mixed liquor of 0. 9% sodium chloride lidocaine and dexamethasone, 1 time. Patients in the SSMTP group were checked waist, scaral, buttocks and legs by tender point examination method recommended by Soft Tissues Surgery Association and treated by twice of strong stimulation massage tender points, every 3 days. Patients in the integrated group received integrated treatment above. The strong stimulation massage tender points treatment was performed immediately after injection once, and once again after 3 ~4 days. Patients in the physiotherapy group received integrated treatment of Ultra - short wave and dynamic interference power once every day, and for seven times totally. All the patients were accessed by M - JOA and VAS before injection, after injection immediately and after 1 week and the results were compared from the aspect of clinical curative effect afterwards. Results 116 patients were finally involved in the result analysis. Before treatment, their M -JOA and VAS scores in the four groups were not significantly different ( P > 0. 05 ); Their VAS scores immediately after treatment were significantly different ( P 0. 05 ). One week after the treatment, VAS scores and M - JOA scores being compared between the four groups, the differences were all significant ( P < 0

  11. Patient satisfaction with nurse-led telephone follow-up after curative treatment for breast cancer

    Directory of Open Access Journals (Sweden)

    Dirksen Carmen D

    2010-04-01

    Full Text Available Abstract Background Current frequent follow-up after treatment for breast cancer does not meet its intended aims, but does depend on expensive and scarce specialized knowledge for routine history taking and physical examinations. The study described in this paper compared patient satisfaction with a reduced follow-up strategy, i.e. nurse-led telephone follow-up, to satisfaction with traditional hospital follow-up. Methods Patient satisfaction was assessed among patients (n = 299 who were participants of a randomized controlled trial investigating the cost-effectiveness of several follow-up strategies in the first year after treatment for breast cancer. Data on patient satisfaction were collected at baseline, three, six and 12 months after treatment, using the Dutch version of Ware's Patient Satisfaction Questionnaire III (PSQ III. In addition to general satisfaction, the PSQ III reports on satisfaction scores for technical competence, interpersonal aspects, and access of care. Regression analysis was used to predict satisfaction scores from whether or not nurse-led telephone follow-up was received. Results Nurse-led telephone follow-up had no statistically significant influence on general patient satisfaction (p = 0.379, satisfaction with technical competence (p = 0.249, and satisfaction with interpersonal aspects (p = 0.662. Regarding access of care, patient satisfaction scores were significantly higher for patients receiving telephone follow-up (p = 0.015. However, a mean difference at 12 months of 3.1 points was judged to be not clinically relevant. Conclusions No meaningful differences were found in satisfaction scores between nurse-led telephone and hospital follow-up in the first year after breast cancer treatment. With high satisfaction scores and the potential to substantially reduce clinic visits, nurse-led telephone follow-up may be an acceptable alternative to traditional hospital follow-up. Trial registration number ISRCTN 74071417.

  12. Mouth opening and trismus in patients undergoing curative treatment for head and neck cancer.

    Science.gov (United States)

    Steiner, F; Evans, J; Marsh, R; Rigby, P; James, S; Sutherland, K; Wickens, R; Nedev, N; Kelly, B; Tan, S T

    2015-03-01

    This study documents mouth opening and the incidence of and factors contributing to trismus (6 months after treatment completion. Patients rated the impact of mouth opening on quality of life from 0 (no effect) to 10 (greatest effect). The mean mouth opening in 120 patients was 40.1mm (range 11-65 mm), with trismus occurring in 34 (28.3%) patients. Surgery and radiotherapy, surgery and chemoradiotherapy, and resection and reconstruction were associated with reduced mouth opening. The mean effect of mouth opening on quality of life for those with and without trismus was 3.8 and 1.5, respectively. There was a significant difference between the mean effect on quality of life for patients with and without trismus for those patients who underwent chemoradiotherapy or combined surgery and radiotherapy (4.0 vs. 1.0, and 3.6 vs. 1.6 respectively). Trismus impacts negatively on patient quality of life. Multi-modality treatment is associated with decreased mouth opening, an increased incidence of trismus, and reduced quality of life. Copyright © 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  13. Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients

    Institute of Scientific and Technical Information of China (English)

    Masayuki Imamura; Izumi Komoto; Shuichi Ota; Takuya Hiratsuka; Shinji Kosugi; Ryuichiro Doi; Masaaki Awane; Naoya Inoue

    2011-01-01

    AIM: To search for the optimal surgery for gastrinoma and duodenopancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1. METHODS: Sixteen patients with genetically confirmed multiple endocrine neoplasia type 1 (MEN 1) and Zollinger-Ellison syndrome (ZES) underwent resection of both gastrinomas and duodenopancreatic neuroendocrine tumors (NETs) between 1991 and 2009. For localization of gastrinoma, selective arterial secretagogue injection test (SASI test) with secretin or calcium solution was performed as well as somatostatin receptor scintigraphy (SRS) and other imaging methods such as computed tomography (CT) or magnetic resonance imaging (MRI). The modus of surgery for gastrinoma has been changed over time, searching for the optimal surgery: pancreaticoduodenectomy (PD) was first performed guided by localization with the SAST test, then local resection of duodenal gastrinomas with dissection of regional lymph nodes (LR), and recently pancreas-preserving total duodenectomy (PPTD) has been performed for multiple duodenal gastrinomas. RESULTS: Among various types of preoperative localizing methods for gastrinoma, the SASI test was the most useful method. Imaging methods such as SRS or CT made it essentially impossible to differentiate functioning gastrinoma among various kinds of NETs. However, recent imaging methods including SRS or CT were useful for detecting both distant metastases and ectopic NETs; therefore they are indispensable for staging of NETs. Biochemical cure of gastrinoma was achieved in 14 of 16 patients (87.5%); that is, 100% in 3 patients who underwent PD, 100% in 6 patients who underwent LR (although in 2 patients (33.3%) second LR was performed for recurrence of duodenal gastrinoma), and 71.4% in 7 patients who underwent PPTD. Pancreatic NETs more than 1 cm in diameter were resected either by distal pancreatectomy or enucleations, and no hepatic metastases have developed postoperatively. Pathological study of the

  14. Monitoring multiple myeloma patients treated with daratumumab

    DEFF Research Database (Denmark)

    McCudden, Christopher; Axel, Amy E; Slaets, Dominique

    2016-01-01

    BACKGROUND: Monoclonal antibodies are promising anti-myeloma treatments. As immunoglobulins, monoclonal antibodies have the potential to be identified by serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE). Therapeutic antibody interference with standard clinical SPE...... and IFE can confound the use of these tests for response assessment in clinical trials and disease monitoring. METHODS: To discriminate between endogenous myeloma protein and daratumumab, a daratumumab-specific immunofixation electrophoresis reflex assay (DIRA) was developed using a mouse anti......-treated patient samples. The DIRA limit of sensitivity was 0.2 g/L daratumumab, using spiking experiments. Results from DIRA were reproducible over multiple days, operators, and assays. The anti-daratumumab antibody was highly specific for daratumumab and did not shift endogenous M-protein. CONCLUSIONS...

  15. Myocardial condition after transcoronary ablation predicts the curative effect in patients with hypertrophic obstructive cardiomyopathy

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Transcoronary ablation of septal hypertrophy (TASH) has been recommended as an option for patients with drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). However, its outcome is varied, and some factors are attributed to the diversity results.1 Up to now, there is no study on the influence of the ablated myocardium's condition on the outcome. We retrospectively analyzed the myocardial perfusion imaging (MPI) obtained before and early after TASH in our patients to explore the relationship between the ablated myocardium's condition and the clinical outcome.

  16. Clinical comparative observation on curative effect of Anisodamine combinded with phenergan in treating vertige%山莨菪碱合用非那根治疗眩晕症176例临床对照观察

    Institute of Scientific and Technical Information of China (English)

    廖纪华

    2013-01-01

    object To compare the effect between Anisodamine cambinded with phenergan and Betahistine in treating vertige . Methods 351 Patients of vertige were ennel ed in the this study and were divided two groups, the freapeutic gneup(176 patients) were treated with Anisodamine(10-20mg/d) and Phenergan(25-50mg/d) intramuscular..injection for 3days. While control groups(175 Patients) were treated with Betahistine infravenuccs injection for 3 days The general effectic rate of the two were observed and conpared. Result. The general effectic rate was 91.5%(161). in ehe therapeetic group and 78.9%(137) in the control group and there was signifient difference between the two group (P<0.05). Conclusion The Anisodamine combined with phenergan had better curative effect than Betahistine injection in treatment of vertigc.%目的:观察山莨菪碱(654-Ⅱ)合用非那根治疗眩晕症的临床疗效。方法351例病人随机分成2组,治疗组176例,使用山莨菪碱注射液10-20mg/d,非那根注射液25-50mg/d,肌注,疗程3天;对照组175例,使用盐酸倍他司汀注射液500ml/d,静脉滴注,疗程3天。观察两组的总有效率。结果治疗组总有效率91.5%(161例),对照组总有效率78.9%(137例)。结论山莨菪碱合用非那根治疗眩晕症有明显效果(P<0.05),优于倍他司汀。

  17. Patient with double cancer--successfully treated.

    Science.gov (United States)

    Djukić, V B; Kastratović, D A; Pendjer, I P; Majstorović, B M; Nikolić, Lj I; Boricić, I V; Vujicić, Z N

    2005-01-01

    Etiology of thrombosis in malignant diseases is multifactorial, and mechanisms that lead to thrombosis include release of the procoagulants from tumor cells (PC), factor related to bed rest, infections, as well as oncological therapy --chemotherapy, hormones, radiotherapy and surgical treatment. Thrombocytosis has frequently been found to be associated with various malignancies. 53 years old female patient hospitalised because of hypopharingeal cancer with metastasis in the left neck. Her state was complicated with deep leg vein trombosis and pseudomonas infection. Persistent thrombocitosis in laboratory monitoring indicated more adequate diagnostic procedures, which led to discovering of Chorioidal Malignant Mellanoma as a second cancer. She was treated: surgically, with antibiotics, with anticoagulants and radiotherapy. Patient was discharged from the hospital in good health condition, free of any other symptom of the malignant disease. Presense of thrombocytosis and idiopatic thrombosis can suggest occult malignancy. It would be prudent to further evaluate the relationship of trombotic events, trombocitosis and head and neck tumors. We suggest anticoagulants to prevent thromboembolic complications, affect the angiogenesis and prevent development of metastatic disease. It may lead to lower mortality rate.

  18. Methylation of breast cancer susceptibility gene 1 (BRCA1) predicts recurrence in patients with curatively resected stage I non-small cell lung cancer.

    Science.gov (United States)

    Harada, Hiroaki; Miyamoto, Kazuaki; Yamashita, Yoshinori; Nakano, Kikuo; Taniyama, Kiyomi; Miyata, Yoshihiro; Ohdan, Hideki; Okada, Morihito

    2013-02-15

    Even after early detection and curative resection of early stage non-small cell lung cancer (NSCLC), a significant fraction of patients develop recurrent disease. Molecular biomarkers that can predict the risk of recurrence thus need to be identified to improve clinical outcomes. Using the methylation-specific polymerase chain reaction assay, promoter methylation of the breast cancer susceptibility gene 1 (BRCA1) was assessed in cancer tissues from 70 patients with curatively resected stage I NSCLC. The clinical relevance of BRCA1 methylation status was evaluated in terms of outcome of the disease. Methylation of the BRCA1 promoter was detected in 13 of 70 patients (18.6%). Multiple logistic regression analysis revealed that BRCA1 methylation was an independent risk factor for recurrence (P = .0197) and that patients with BRCA1 methylation demonstrated significantly poorer recurrence-free survival compared to those without (P = .0139). Cox's proportional hazard regression analysis revealed that BRCA1 methylation was an independent risk factor for recurrence-free survival (P = .0155). Methylated BRCA1 can be a potential biomarker that predicts the prognosis after curative resection of stage I NSCLC. Considering that BRCA1 plays a role in chemotherapy-induced apoptosis, it is plausible that identification of methylated BRCA1 could provide information that is clinically relevant to tailored adjuvant therapy. Copyright © 2013 American Cancer Society.

  19. Assessment of prognosis and curative effect in patients with chronic severe hepatitis using the model for end-stage liver disease scores

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Severe hepatitis is the most severe liver disease, with poor prognosis and high mortality. We explored the practical use of the model for end-stage liver disease (MELD) on clinical and the molecular adsorbents recirculating system (MARS) on chronic severe hepatitis to predict the short-term prognosis of patients with chronic severe hepatitis using the MELD score and the curative effect of MARS treatment.

  20. Evaluation of the Curative Effect of External Beam Radiotherapy and Brachytherapy for Tongue Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Ping Wang; Qingsong Pang

    2007-01-01

    OBJECTIVE To evaluate the curative effect of external beam radiotherapy (EBRT) and brachytherapy (BT) for tongue carcinoma. METHODS From 1991 to 2003, 35 patients received EBRT and BT in our department. We analyzed their curative and side effects retrospectively. RESULTS Local control was 80%. The 3-year overall (OS) and disease specific survival (DSS) rates were 75% and 79%. One patient developed metastases. Three patients (9%) developed different late complications. CONCLUSIONS Local regional control, survival, and complications in patients with tongue carcinoma treated by EBRT and BT have been satisfactory.

  1. 中药茶饮结合耳穴治疗中学生痤疮120例疗效观察%Curative Observation on Herbal Tea Combined with Ear Acupoint in Treating 120 Middle School Students with Acne

    Institute of Scientific and Technical Information of China (English)

    安维新; 张正华

    2016-01-01

    Objective: To survey curative effects of herbal tea and ear acupoint in the treatment for the students with acne. Methods: All 633 cases who were suffering from acne in health examination ofJiayuguan2014 College entrance examination, 230 patients were chosen and randomized into 120 cases of the treatment group and 110 cases of the control group, the treatment group were treated by herbal tea and ear acupoint and the control group orally took Viaminati capsules, 25mg each time, twice per day, and 0.025% tretinoin cream for external use, skin lesions ofthe acne were observed in six weeks. Results: Herbal tea and ear acupoint are effective in treating acne, and total ef-fective rate reached 95.8%. Conclusion: Spicy and sweet food and staying up late are the important inducing and ag-gravating factors of acne, herbal tea and ear acupoint are superior to western medicine in treating acne, and it's sim-ple and easily to accept by the students.%目的:观察中药茶饮和耳穴治疗中学生痤疮的临床疗效。方法:将嘉峪关市2014年高考体检痤疮学生633例,选择其中230例患者并随机分为治疗组120例和对照组110例,治疗组以中药茶饮结合耳穴治疗,对照组口服维胺酯胺囊25 mg/次,2次/d,并外用0.025%维A酸乳膏,6周后观察痤疮皮损情况。结果:中药茶饮结合耳穴治疗痤疮效果明显,总有效率达95.8%。结论:辛辣、甜腻饮食和熬夜是痤疮重要的诱发和加重因素,中药茶饮结合耳穴治疗学生痤疮优于西药对照组,而且方法简单,易为学生接受。

  2. Gastric carcinoma: curative resection and adjuvant chemotherapy.

    Science.gov (United States)

    Carrillo Hernández, J F; Ernesto de Obaldía Castillo, G; Ramírez Ortega, C; Frías Mendivil, M; Pardo, M

    1994-01-01

    A retrospective study of gastric adenocarcinoma treated with surgery as curative attempt was performed at the Oncology Service, in the Hospital Regional 20 de Noviembre, ISSSTE. Morbidity and mortality of the surgical procedures were evaluated, the significance of several risk factors and the survival impact of adjuvant chemotherapy with 5-fluorouracil (5-FU) and mitomycin C (MMC). In the period from 1975 to 1991 a total of 483 new cases were seen. In only 54 patients (11.2%) was it possible to undertake a curative resection. The patients were assigned to three groups of treatment: surgery alone (14 cases), surgery + 5-FU (19 cases), and surgery + 5-FU+MMC (21 cases). Three different types of surgical techniques are regularly performed in our service for gastric cancer treatment: Billroth II distal gastrectomy, total gastrectomy with Roux-En-Y reconstruction, and esophagogastrectomy with esophagogastrostomy. Surgical morbidity and mortality was low, with 9% of duodenal stump fistulas and 27% with partial stenosis of esophagojejunostomy; the operative mortality was zero. Chemotherapy toxicity was transient and low, no related deaths were recorded. The prognostic factors associated significantly with survival were lymph node status and tumor penetration. The histologic differentiation as well as the tumor location and type of surgery had no significance. The estimated 5-year survival of the patients treated with surgery alone was 62%, while that of the patients treated with surgery plus chemotherapy was 38%. These groups were not comparable, however, because of important differences in their prognostic factors. The groups treated with 5-FU alone or in combination with MMC had no survival difference between them.(ABSTRACT TRUNCATED AT 250 WORDS)

  3. The curative effect of treating the pigmentation after burn by Herbal Mask%中药面膜综合治疗面部烧伤后色素沉着疗效观察

    Institute of Scientific and Technical Information of China (English)

    涂雪松; 彭友林; 胡友红

    2015-01-01

    Objective To observe the curative effects of treating the pigmentation after burn with Herbal Mask. Methods 46 cases with facial pigmentation after second degree burn were treated with external Herbal Mask.Then,observed the pigmentation faded and curative effects. Results Pigmentation had subsided after a course of treatment. Conclusion It is a method worthy of popularization to treat the pigmentation after burn by Herbal Mask Combined with other auxiliary means.%目的:观察中药面膜等综合疗法对面部烧伤后色素沉着的疗效。方法:选择2013年1月-2014年6月收治的面部烧伤后色素沉着患者46例,均为面部浅Ⅱ度烧伤治疗后遗留的不同程度色素沉着,给予中药面膜综合治疗后,观察色素沉着消退情况。结果:经过一个疗程的治疗,色素沉着明显消退。结论:中药面膜等综合手段治疗面部烧伤后色素沉着,方便、有效,值得临床推广应用。

  4. [Second primary tumors in patients treated at an early age for Hodgkin's disease; consequences for the follow-up].

    Science.gov (United States)

    Aleman, B M; Klokman, W J; van Leeuwen, F E

    2000-08-05

    As curative treatment is now available for a substantial group of cancer patients, it is increasingly important to evaluate how late complications of treatment affect their long-term survival. Two recent publications summarize the second malignancies in survivors of Hodgkin's disease treated during adolescence or young adulthood. After more than 20 years' follow-up, the risk of solid tumours is still much greater in survivors of Hodgkin's disease than in the population at large. Age at treatment has a major effect on the occurrence of second malignancy. Reassuringly, the increased risk of solid tumours in patients who were less than 20 years of age seems to decrease as these patients grow older. The data of these studies suggest that chemotherapy may increase the risk of solid tumours from radiotherapy. Special alertness to symptoms of second malignancies is advised during follow-up after treatment for Hodgkin's disease, especially in patients treated below the age of 20.

  5. Thalidomide in Treating Patients With Myelodysplastic Syndrome

    Science.gov (United States)

    2013-01-23

    Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Previously Treated Myelodysplastic Syndromes; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Refractory Anemia With Ringed Sideroblasts; Secondary Myelodysplastic Syndromes

  6. 胸腔镜治疗自发性气胸临床疗效观察%Clinical Curative Effect Observation of Thoracoscope Treating Spontaneous Pneumothorax

    Institute of Scientific and Technical Information of China (English)

    徐涑坤

    2015-01-01

    Objective To observe the clinical effect of spontaneous pneumothorax patients treated by thoracoscope. Methods Thoracic surgery in our hospital for treatment of 80 patients with spontaneous pneumothorax were divided into groups of thoracoscope and thoracotomy group, group folio chest, open heart surgery for the implementation of thoracoscope surgery in patients with thoracoscope group. To observe the surgical treatment effect of two groups of patients. Results The intraoperative blood loss in patients with thoracoscope group was obviously less than thoracotomy group of patients (P<0.05), pain score (VAS) was lower than that in group thoracotomy patients (P<0.05), hospitalization time significantly shorter than thoracotomy group of patients (P<0.05). Conclusion The thoracoscope surgery in patients with spontaneous pneumothorax, body pain small, the surgical treatment effect is good.%目的:观察采用胸腔镜治疗自发性气胸患者的临床效果。方法将在我院胸外科接受治疗的80例自发性气胸患者分成胸腔镜组和开胸组,对开胸组患者实施开胸手术治疗,对胸腔镜组患者实施胸腔镜手术治疗。观察两组患者的手术治疗效果。结果胸腔镜组患者的术中出血量少于开胸组患者(P<0.05),疼痛评分(VAS)低于开胸组患者(P<0.05),住院时间短于开胸组患者(P<0.05)。结论胸腔镜手术治疗自发性气胸患者,机体痛苦小,手术治疗效果好。

  7. [Curative effect of decitabine combined with cytokine-induced killer cells in two elderly patients with acute myeloid leukemia].

    Science.gov (United States)

    Chang, Cheng; Yang, Bo; Zhang, Lin; Zhu, Hong-Li; Lu, Xue-Chun; Guo, Bo; Cai, Li-Li; Han, Wei-Dong; Wang, Yao; Fan, Hui; Li, Su-Xia; Liu, Yang; Yang, Yang; Zhai, Bing; Ran, Hai-Hong; Lin, Jie; Zhang, Feng

    2013-02-01

    This study was aimed to evaluate the effectiveness and safety of low methylation drug decitabine combined with autologous cytokine induced killer cells (CIK) to treat the elderly patients with acute myeloid leukemia (AML). Two AML patients aged over 80 years old were diagnosed and treated in our department from 2006 to 2012; both company with MDS history, and one case was M4-type, another case was M6-type according to FAB classification. The changes in lymphocyte subsets, hematologic response, transfusion frequency, leukemic gene expression, obtaining CR or PR, quality of life and survival time of the patients with different treatment regimen (decitabine alone; CIK alone; decitabine combined with CIK) were systematically observed. The results showed that therapy of decitabine combined with CIK cells could reduce bone marrow suppression extent, decrease the frequency and volume of blood transfusion, and prolong the duration of partial remission, compared with the single use of CIK cell infusion and single use of decitabine treatment. Meanwhile, the kinds of expressed genes associated with leukemia decreased and the survival time was prolonged obviously. The patients' life quality significantly improved. It is concluded that decitabine combined with CIK for treatment of elderly patients with AML is safe and effective.

  8. The dynamic pattern of recurrence in curatively resected non-small cell lung cancer patients: Experiences at a single institution.

    Science.gov (United States)

    Yamauchi, Yoshikane; Muley, Thomas; Safi, Seyer; Rieken, Stefan; Bischoff, Helge; Kappes, Jutta; Warth, Arne; Herth, Felix J F; Dienemann, Hendrik; Hoffmann, Hans

    2015-11-01

    To investigate the hazard function of tumor recurrence in patients with completely (R0) resected non-small cell lung cancer. A total of 1374 patients treated between 2003 and 2009 with complete resection and systematic lymph node dissection were studied. The risk of recurrence at a given time after operation was studied utilizing the cause-specific hazard function. Recurrence was categorized as local recurrence or distant recurrence. The risk distribution was assessed using clinical and pathological factors. The hazard function for recurrence presented an early peak at approximately 10 months after surgery and maintained a tapered plateau-like tail extending up to 8 years. A similar risk pattern was detected for both local recurrence and distant recurrence, while the risk of distant recurrence was higher than that of local recurrence. The double-peaked pattern of hazard rate was present in several subgroups, such as p-stage IA patients. A comparison of histology and status of nodal involvement showed that pN1-2 adenocarcinoma patients demonstrated a high hazard rate of distant recurrence and that pN0 adenocarcinoma patients exhibited a small recurrent risk for a longer time. Squamous cell carcinoma patients showed only little difference in risk. The data may be useful to select patients at high risk of recurrence and may provide information for each patient to decide how to manage the postoperative follow-up individually. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  9. Curative radio therapy in elderly patients with endometrial cancer. Patterns of relapse, toxicity and quality of life

    Energy Technology Data Exchange (ETDEWEB)

    Huguenin, P.; Baumert, B.; Luetolf, U.M.; Glanzmann, C. [Univ. Hospital Zuerich (Switzerland). Radiation Oncology; Wight, E. [Univ. Hospital Zuerich (Switzerland). Gynecologic Oncology

    1999-07-01

    Purpose: To assess survival, disease-specific survival, acute and late toxicity and quality of life in patients with curable endometrial carcinoma treated with adjuvant or primary radiotherapy at the age {>=}75 years. Patients and methods: In a prospective study, outcome was regularly assessed in 49 patients treated between 1991 and 1995 at a median age of 78.4 years. Radiotherapy was applied using the same concept as in younger patients. Thirty-eight patients received postoperative adjuvant radiotherapy (vaginal insertions only: n=18; external and vaginal insertions: n=17; external radiotherapy only: n=3), 8 patients were treated for a vaginal recurrence. Three patients received primary radiotherapy. Median pelvic dose was 39.6 Gy (ICRU) with 1.8 Gy per fraction (4 fields). Vaginal HDR radiotherapy consisted of 5 times 5 Gy at 0.5 cm depth in cases with no external radiotherapy, and of 3 times 5 Gy in addition to pelvic radiotherapy, respectively. Median follow-up was 3.2 years. The EORTC QLQ-C30 was used for self-assessment of quality of life. Results: Survival and disease-specific survival at 5 years was 64% and 84%, respectively. There was no pelvic or vaginal recurrence in patients with Stage IA to IIB. Patients with positive adnexa and those treated for vaginal recurrence relapsed in 50%. Two patients (4%) did not complete radiotherapy because of severe diarrhea. Grade 4 late complications were observed in 1/38 patients following adjuvant radiotherapy and in 2/8 patients treated for a recurrence. The actuarial rate of Grade 3 to 4 complications was 7% at 3 years. Quality of life was good in most cases and remained constant over time. (orig.) [Deutsch] Ziel: Analyse des Gesamtueberlebens, des tumorspezifischen Ueberlebens, der pelvinen Tumorkontrolle, der Akut- und Spaettoxizitaet sowie der Lebensqualitaet bei Patientinnen, die mit 75 oder mehr Jahren wegen eines Karzinoms des Corpus uteri mit kurativem Ziel bestrahlt wurden. Patienten und Methode: Zwischen

  10. 温针夹脊穴治疗腰椎间盘突出症的临床疗效观察%Clinical curative effect observation on treating lumbar disc herniation with warm acupuncture in Jiaji point

    Institute of Scientific and Technical Information of China (English)

    易建良; 袁锦波; 杨帆; 冯新国; 刘晓敏

    2013-01-01

    Objective: To observe the effect of acupuncture on treating lumbar disc herniation and compare the curative effect difference between warm acupuncture and simple acupuncture. Methods:62 patients with lumbar disc herniation were randomly divided into acupuncture group and warm acupuncture, 31 for each. Both groups were select bilateral Shenyu point, Jiaji point and the affected side Huantiao, Weizhong, Ashi point, 1 time a day, 10 times for 1 course. Changes of low back pain score (JOA score) and the McGill pain scale score between two groups were observed before and after treatment. Results:After treatment, JOA scores of two groups were significantly increased (P<0.01), the McGill Pain Questionnaire scores were significantly decreased (all P<0.01), warm acupuncture group in improving JOA scores and lower VAS score better than the acupuncture group (P<0.05). Conclusion: Acupuncture in the treatment of lumbar disc herniation is safe and effective, compared with conventional acupuncture group, warm acupuncture in improving the pain threshold of patients has more significant effect.%目的:观察针灸治疗腰椎间盘突出症的临床疗效,比较温针及单纯针刺的疗效差异。方法:将计入统计的62例腰椎间盘突出症患者随机分为针刺组和温针组,每组31例。均取双侧肾俞、夹脊穴及患侧环跳、委中、阿是穴,1次/d,10次为1个疗程。观察两组治疗前后下腰痛评分标准(JOA评分)及McGill疼痛量表评分变化情况。结果:两组患者治疗后JOA评分均明显上升(P<0.01),McGill疼痛量表各项评分均明显下降(均P<0.01),且温针组在提高JOA评分和降低VAS评分方面优于针刺组(P<0.05)。结论:温针治疗腰椎间盘突出症安全有效,与常规针刺组相比,其在提高患者痛阈方面疗效更加显著。

  11. Curative Effect Analysis of Inverse Bavel Incision Gingivectomy in Treat-ment of Gingival Hyperplasia%内斜切口牙龈切除术治疗牙龈增生的疗效分析

    Institute of Scientific and Technical Information of China (English)

    张本婷

    2016-01-01

    Objective To study and analyze the curative effect of inverse bavel incision Gingivectomy in treatment of gingi-val hyperplasia. Methods 84 cases of patients with gingival hyperplasia diagnosed in our hospital from December 2014 to February 2016 were selected and divided into two groups with 42 cases in each, the control group were treated with gin-givectomy, the experimental group were treated with inverse bavel incision gingivectomy, and the treatment effect and satis-factory degree of patients were compared between the two groups. Results After treatment, the effective rate in the control group was much lower than that in the experimental group, (81% vs 95%), at the same time, the treatment satisfactory de-gree in the experimental group was obviously higher than that in the control group, (90% vs 62%), P<0.05. Conclusion In clinic, gingival hyperplasia is a very common oral disease, the patients with gingival hyperplasia were treated with the in-verse bavel incision gingivectomy usually, and it has an extremely high treatment effective rate with obvious effect, and it is safe and reliable, which is well worth great promotion in clinic.%目的:探讨和分析内斜切口牙龈切除术治疗牙龈增生的疗效。方法整群选取2014年12月—2016年2月医院诊治的牙龈增生患者84例,分为实验组和对照组两组,各42例。对照组采用牙龈切除术治疗,实验组采用内斜切口牙龈切除术进行治疗。把两组的治疗效果和患者满意度进行对比。结果每组经过各自方法治疗后,采用传统牙龈切除术的对照组的有效率为81%,在有效率方面远远低于采用内斜切口牙龈切除术的实验组的有效率(95%)。同时,在患者满意度的方面,实验组治疗满意度为90%,显著高于对照组的62%(P<0.05)。结论在临床上,牙龈增生是一种十分常见的口腔疾病,通常情况都是采用内斜切口牙龈切除术对牙龈增生患者进行治疗,这种治

  12. Pretreatment glucose status determines HCC development in HCV patients with mild liver disease after curative antiviral therapy.

    Science.gov (United States)

    Huang, Chung-Feng; Yeh, Ming-Lun; Huang, Cing-Yi; Tsai, Pei-Chien; Ko, Yu-Min; Chen, Kuan-Yu; Lin, Zu-Yau; Chen, Shinn-Cherng; Dai, Chia-Yen; Chuang, Wan-Long; Huang, Jee-Fu; Yu, Ming-Lung

    2016-07-01

    Although diabetes mellitus (DM) is known to increase the risk of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), the impact of dynamic glucose status on HCC occurrence in chronic hepatitis C (CHC) patients receiving antiviral therapy is unclear. In total, 1112 biopsy-proven patients treated with peginterferon/ribavirin were enrolled in this study. Both pretreatment and post-treatment glucose status, including 75 g oral glucose tolerance test (OGTT), were measured to evaluate the association between glucose status and the development of HCC. Of the 1112 patients evaluated, 93 (8.4%) developed HCC >5183.8 person-years of follow-up (annual incidence rate: 1.79%). DM only influenced the risk of developing CC in patients with mild liver disease (F0-2) and a sustained virological response (SVR) but not in other patient subpopulations. Cox-regression analysis demonstrated that the strongest factor associated with HCC in patients with mild liver disease and SVR was the presence of DM (hazard ratio [HR]/95 % confidence intervals [CI]: 3.79/1.420-10.136, P = 0.008), followed by age (HR/CI: 1.06/1.001-1.117, P = 0.046) and platelet count (HR/CI: 0.989/0.979-1.000, P = 0.05). The percentages of SVR patients with F0-2 with normoglycemia, pre-DM, sub-DM (pre-sDM), and DM before treatment were 45.3% (n = 267), 29.9% (n = 176), 15.6% (n = 92), and 9.2% (n = 54), respectively. The percentages of HCC in patients with normoglycemia, pre-sDM, and DM were 1.1%, 3.7%, and 11.1%, respectively (trend P < 0.001). Sixteen of the 19 (84.2 %) HCC patients possessed glucose abnormality (including 6 patients with DM and 10 patients with pre-sDM) before antiviral therapy. Compared to patients with normoglycemia, the incidence of HCC increased gradually from pre-sDM (HR: 3.6, P = 0.05) to DM (HR: 11.6, P = 0.001) (adjusted trend P = 0.004). We concluded that DM is a critical determinant for the development of HCC in SVR patients with mild liver disease. Pre-sDM status

  13. Curation of Frozen Samples

    Science.gov (United States)

    Fletcher, L. A.; Allen, C. C.; Bastien, R.

    2008-01-01

    NASA's Johnson Space Center (JSC) and the Astromaterials Curator are charged by NPD 7100.10D with the curation of all of NASA s extraterrestrial samples, including those from future missions. This responsibility includes the development of new sample handling and preparation techniques; therefore, the Astromaterials Curator must begin developing procedures to preserve, prepare and ship samples at sub-freezing temperatures in order to enable future sample return missions. Such missions might include the return of future frozen samples from permanently-shadowed lunar craters, the nuclei of comets, the surface of Mars, etc. We are demonstrating the ability to curate samples under cold conditions by designing, installing and testing a cold curation glovebox. This glovebox will allow us to store, document, manipulate and subdivide frozen samples while quantifying and minimizing contamination throughout the curation process.

  14. Long-term curative effect of botulinum toxin A(BTXA) on treating spam of eyelid and facial muscle%肉毒杆菌毒素A治疗眼睑及面肌 痉挛远期疗效观察

    Institute of Scientific and Technical Information of China (English)

    田秋霞; 刘元真

    2000-01-01

    Objective To discuss the long-term curative effect of botulinum toxin A(BTXA) for treating spasm of eyelid and facial muscle.Methods Ninty-two patients with spasm of eyelid and facial muscle were treated with BTXA and observed for a long term.Results After being injected with BTXA for 1~4 days, the spasm relieved gradually. Sixteen weeks later, the spasm symptoms relapsed. The relapse began mostly from eyelid spasm. The facial spasm's relief time was longer. lt might be up to 24 weeks. After injection, the patients had some slight complications of facial expression numb, ptosis and fissura palpebrae. The above complication symptoms recovered by themselves after two weeks. Conclusion The curative effect of BTXA on treating spasm of eyelid and facial muscle is reliable.%目的探讨肉毒杆菌毒素A(botulinum A toxin,BTXA)治疗眼睑及面部肌肉痉挛的远期疗效。方法对92例眼睑及面部肌肉痉挛患者用BTXA注射治疗,随诊观察其远期疗效。结果 BTXA注射后1~4d痉挛逐渐缓解,维持16wk左右后症状复发。复发多由眼睑痉挛开始,面部痉挛缓解时间长,可达24wk。注射后可见表情麻木、上睑下垂、睑裂闭合不全等并发症,但均较轻,且2wk后多能自行恢复。结论 BTXA治疗眼睑面部肌肉痉挛疗效确切。

  15. High mortality among heart failure patients treated with antidepressants

    DEFF Research Database (Denmark)

    Veien, Karsten Tang; Videbæk, Lars; Schou, Morten

    2011-01-01

    This study was designed to assess whether pharmacologically treated depression was associated with increased mortality risk in systolic heart failure (SHF) patients.......This study was designed to assess whether pharmacologically treated depression was associated with increased mortality risk in systolic heart failure (SHF) patients....

  16. Observation on curative effects of low molecular weight heparin of prolongable curative course on treating unstable angina pectoris%低分子肝素延长疗程治疗不稳定型心绞痛疗效观察

    Institute of Scientific and Technical Information of China (English)

    胡亚力; 苏珍; 白洪雁; 苏晓燕; 刘怡

    2001-01-01

    目的:观察低分子肝素延长疗程治疗不稳定型心绞痛的疗效。方法:同期入院的不稳定型心绞痛患者168例,随机分为2组,均在常规治疗基础上应用低分子肝素(立迈青)皮下注射,每日2次。A组应用1周,B组应用3周,第1周用量2组均为每次120 IU/kg,第2~3周B组用量每次100 IU/kg。结果:早期(第7日)观察2组总有效率分别为75.9%、77.4%,疗效无显著差异(P>0.05);心血管意外事件(急性心肌梗死、心脏性或非心脏性死亡、药物无法控制病情需行急性血运重建术)及出血,在2组的发生率无显著差异(P>0.05) 。晚期(第8~30日)观察2组总有效率分别为87.2%、97.5%,有显著性差异(P0.05) 。结论:低分子肝素延长疗程治疗不稳定型心绞痛疗效较短程应用疗效为好,且不增加出血发生率。%Objective:To observe the curative effect of low molecular weight heparin of prolongable curative course on treating unstable angina pectoris.Methods:One hundred and sixtyeight cases with unstable angina pectoris who were admitted into hospital at the same period were randomly divided into two groups.Both groups were subcutaneously injected by low molecular weight heparin combined with conventional therapy,two times a day for one week in group A and three weeks in group B respectively.In the first week,the dosage of heparin in group A and B was 120 IU/kg every time,from second to third week,the dosage of heparin in group B was 100 IU/kg every time.Results:The total effective rates in group A and group B were 75.9% and 77.4% respectively in early stage (seventh day),and the difference was not significant (P>0.05).The incidences of cardiovascular accidental events (acute myocardial infarction,cardiac death,uncardiac death,the illness which could not be controlled by the medicine and should be treated with acute reconstruction of blood circulation) and haemorrhage in both groups had not significantly different

  17. Brain tumors in patients primarly treated psychiatrically

    Directory of Open Access Journals (Sweden)

    Ignjatović-Ristić Dragana

    2011-01-01

    Full Text Available Introduction. Psychiatric symptoms are not rare manifestations of brain tumors. Brain tumors presented by symptoms of raised intracranial pressure, focal neurological signs, or convulsions are usually first seen by the neurologist or less frequently by the neurosurgeon in routine diagnostic procedures. On the other hand, when psychiatric symptoms are the first manifestation in “neurologically silent” brain tumors, the patients are sent to the psychiatrist for the treatment of psychiatric symptoms and brain tumors are left misdiagnosed for a long period of time. Case Report. We presented three patients with the diagnosed brain tumor where psychiatrist had been the first specialist to be consulted. In all three cases neurological examination was generally unremarkable with no focal signs or features of raised intracranial pressure. CT scan demonstrated right insular tumor in a female patient with obsessive-compulsive disorder (OCD; right parietal temporal tumor in a patient with delusions and depression and left frontal tumor in a patient with history of alcohol dependency. Conclusion. Psychiatric symptoms/disorders in patients with brain tumors are not specific enough and can have the same clinical presentation as the genuine psychiatric disorder. Therefore, we emphasize the consideration of neuroimaging in patients with abrupt beginning of psychiatric symptoms, in those with a change in mental status, or when headaches suddenly appear or in cases of treatment resistant psychiatric disorders regardless the lack of neurological symptoms.

  18. Foreign patients in ER: receiving, understanding, treating

    Directory of Open Access Journals (Sweden)

    Alberto Dal Molin

    2006-06-01

    Full Text Available In the last years the presence of foreign patients inside Emergency Departments is increased, this means many problems, like misunderstanding, communication difficulties and more problematic situations when, our work or our expectations meet the values sideboards and life style of our patients. This article purpose is to describe this phenomenon inside Biella Emergency Departments, because if you know a situation you can solve it better.

  19. God of the hinge: treating LGBTQIA patients.

    Science.gov (United States)

    Boland, Annie

    2017-11-01

    This paper looks at systems of gender within the context of analysis. It explores the unique challenges of individuation faced by transsexual, transgender, gender queer, gender non-conforming, cross-dressing and intersex patients. To receive patients generously we need to learn how a binary culture produces profound and chronic trauma. These patients wrestle with being who they are whilst simultaneously receiving negative projections and feeling invisible. While often presenting with the struggles of gender conforming individuals, understanding the specifically gendered aspect of their identity is imperative. An analyst's unconscious bias may lead to iatrogenic shaming. The author argues that rigorous, humble inquiry into the analyst's transphobia can be transformative for patient, analyst, and the work itself. Analysis may, then, provide gender-variant patients with their first remembered and numinous experience of authentic connection to self. Conjuring the image of a hinge, securely placed in the neutral region of a third space, creates a transpositive analytic temenos. Invoking the spirit of the Trickster in the construction of this matrix supports the full inclusion of gender-variant patients. Nuanced attunement scaffolds mirroring and the possibility of play. Being mindful that gender is sturdy and delicate as well as mercurial and defined enriches the analyst's listening. © 2017, The Society of Analytical Psychology.

  20. The Curative Effect of High-dose Mecobalamin Treating Diabetes Peripheral Neuropathy%大剂量甲钴胺对糖尿病周围神经损害的影响

    Institute of Scientific and Technical Information of China (English)

    阚瑛; 赵焱

    2009-01-01

    目的 观察甲钴胺对糖尿病周围神经损害恢复的影响.方法 将128例糖尿病周围神经病变的患者随机分为3组,治疗1组给予甲钴胺1500 μg加入250 ml生理盐水中静脉滴注,1次/d,连用2周;治疗2组给予甲钴胺500微克肌肉注射,隔日1次,连用2周;对照组给予维生素B120.5毫克肌肉注射,1次/d,连用2周.每组均加以银杏达莫(杏丁)注射液辅助治疗.结果 治疗1组总有效率96.9%,治疗2组总有效率91.7%,均明显高于对照组53.3%(P0.05).the symptoms, physical signs and nerve conduction velocity(NCV) of treatment groups showed significant improvement compared with the control group. The clinical curative effect between the two treatment groups have statistical significant benefits. Conclusion High-dose mecobalamin can have obvious curative effect on treating DPN.

  1. Curative Effect of Arris Needle Bleeding Therapy in Treating Nasal Supenllus Period Rosacea%三棱针刺血疗法治疗鼻赘期酒渣鼻临床观察

    Institute of Scientific and Technical Information of China (English)

    石新荣; 原方; 史爱华

    2011-01-01

    目的:观察三棱针刺血疗法治疗鼻赘期酒渣鼻的疗效.方法:用三棱针刺血疗法治疗鼻赘期酒渣鼻38例,10 d治疗1次,3次1个疗程,共治疗1-2个疗程.结果:经1-2个疗程治疗后,治愈20例,好转17例,无效1例,有效率97.37%.结论:三棱针刺血疗法治疗鼻赘期酒渣鼻是具有良好疗效的非药物疗法.%Objective:To observe the curative effect of triangle -edged needle in treating grogblossom period of rosacea. Methods:Using triangle -edged needle acupuncture bleeding therapy nasal supenllus period rosacea 38 cases ,one time per 10 days,3 times as a course of treatment, 1 or 2 course of treatment for each. Results: After 1 - 2 treatment courses ,20 cases were cured, 17 cases were improved, l case ineffective,the total effective was 97.37%. Conclusion :Triangle -edged needle acupuncture bleeding therapy grngblossom period rosacea has the curative effect of the undrug therapy.

  2. Clinical curative effect analysis of huangqi-guizhi-wuwu decoction joint mecobalamine treating diabetic peripheral neuropathy%黄芪桂枝五物汤联合甲钴胺治疗糖尿病周围神经病变临床疗效分析

    Institute of Scientific and Technical Information of China (English)

    黄连河

    2015-01-01

    Objective:To explore the curative effect and application value of huangqi-guizhi-wuwu decoction joint mecobalamine treating diabetic peripheral neuropathy.Methods:94 cases of patients with diabetic peripheral neuropathy were divided into the observation group and the control group according to random number table method.The control group were treated with mecobalamine,and the observation group were treated with huangqi-guizhi-wuwu decoction joint mecobalamine,then the clinical curative effect of the two groups were compared.Results:The total effective rate of the control group was 76.60% and that of the observation group was 95.74% .There was statistically significant difference between the groups(P<0.05).Conclusion:Huangqi-guizhi-wuwu decoction joint mecobalamine treating diabetic peripheral neuropathy had reliable curative effect and improved the clinical symptoms and signs effectively.%目的:探讨黄芪桂枝五物汤联合甲钴胺治疗糖尿病周围神经病变的治疗效果及应用价值。方法:收治糖尿病周围神经病变患者94例,采用随机数字表法分为观察组和对照组。对照组给予甲钴胺治疗,观察组给予甲钴胺联合中药黄芪桂枝五物汤治疗,比较两组临床疗效。结果:对照组治疗总有效率76.60%,观察组治疗总有效率95.74%,组间对比差异有统计学意义(P<0.05)。结论:黄芪桂枝五物汤联合甲钴胺治疗糖尿病周围神经病变疗效可靠,能有效改善临床症状和体征。

  3. An exploration of the existential experiences of patients following curative treatment for cancer: reflections from a U.K. Sample.

    Science.gov (United States)

    Lagerdahl, Anna S K; Moynihan, Manus; Stollery, Brian

    2014-01-01

    The existential experiences associated with cancer diagnosis and treatment are well researched, but the posttreatment phase is relatively underexplored. Using semistructured interviews and theory-led thematic analysis this qualitative study investigated the existential experiences of eight cancer survivors who had successfully completed curative treatment. Being in remission had led to deep existential reflections (i.e., death anxiety, freedom, isolation, and meaning making), and some participants faced considerable challenges that affected their emotional well-being. Understanding cancer survivors' existential challenges should enable health care professionals to engage with the emerging shift from the predominantly medically focused posttreatment care to a more holistic approach.

  4. Comparison of curative effects of two kinds internal fixation in treating calcaneal fractures%跟骨骨折两种内固定手术疗效比较

    Institute of Scientific and Technical Information of China (English)

    徐海栋; 赵建宁; 陈勇

    2013-01-01

    目的 对比分析可塑钛板及空心钉内固定治疗跟骨骨折的临床疗效.方法 对40例(52足)跟骨骨折根据自愿原则分别进入可塑钛板内固定组及空心钉内固定组进行手术治疗,各20例(26足),对比分析两组患者手术时间、术中出血量、骨折愈合时间及术后足踝功能.结果 40例均获得随访6~18个月,平均(10.42±1.33)个月.空心钉内固定组与可塑钛板内固定组比较,手术时间较短、出血量较多,差异有统计学意义(P<0.05);骨折愈合时间、Bohler角、Gissane角、踝关节活动范围两组差异无统计学意义(P>0.05);两组并发症发生率差异无统计学意义(P>0.05).结论 空心钉内固定治疗跟骨骨折能有效防止关节面复位后再塌陷及骨折移位,手术方式简单、创伤小,具有较大的徼创手术优势.%Objective To explore the curative effect of plastic titanic plates and hollow screws in the treatment of calcaneal fractures. Methods Forty patients (52 feet) with calcaneal fractures were studied. They were divided into two groups,20 patients (26 feet) were treated with plastic titanic plates and 20 patients(26 feet) were treated with hollow screws. The operative times,blood loss,fractures healing time,and postoperative function scores were recorded in two groups. And the therapeutic effect in two groups was compared. Results All of 40 cases were followed up for 6~18 months, with an average of (10.42± 1.33) months. The operative time and volume of blood loss in hollow screws group were significantly shorter or reduced than those in plastic titanic plates group. The difference was statistically significant(P0.05). The incidence of complications was not significantly different in two groups(P >0.05). Conclusion The hollow screws in treatment of calcaneal fractures can effectively prevent the collapse of articular surface and re-displacement again. The surgery is simple with less trauma,strong advantages of minimally

  5. Curating the Shelves

    Science.gov (United States)

    Schiano, Deborah

    2013-01-01

    Curation: to gather, organize, and present resources in a way that meets information needs and interests, makes sense for virtual as well as physical resources. A Northern New Jersey middle school library made the decision to curate its physical resources according to the needs of its users, and, in so doing, created a shelving system that is,…

  6. Observation on Curative Effect of Hypertension Treated with Combination of Lotensin and Amlodipine%洛汀新与安内真联合治疗高血压150例疗效观察

    Institute of Scientific and Technical Information of China (English)

    查滨; 孙久清; 赵明惠; 周殷

    2005-01-01

    Objective To compare the curative effect on treatment d combination d lotensin and amlodipine and alone with lotensin or amlodipine. Methods 371 cases of essential hypertension were divided into A lotensin and amlodipine group (150cases), B lotensin group (105 cases ) and C amlodinpine group randomly and were treated respectively for 4 weeks. Ambulatory blood preasure monitoring was used to assess the arti-hypertensive efficacy, urine and renal function were also detected. Results The mean blood pressure in 24 h dropped in all three goupe, but mean blood pressure in 24 h dropped significanfly in group A. Group Awas also superior to the others in reducing proteinaria and improving renal function,Conclusion Associated spplication with lotensin and amlodinpine not only had good efficacy in steadily controlling the blood pressure in EH cases but also improve renal function.

  7. Second lung cancers in patients successfully treated for lung cancer.

    Science.gov (United States)

    Johnson, B E; Cortazar, P; Chute, J P

    1997-08-01

    The rate of developing second lung cancers and other aerodigestive tumors in patients who have been treated for both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) is approximately 10-fold higher than other adult smokers. The risk of second lung cancers in patients surviving resection of NSCLC is approximately 1% to 2% per year. The series reported show that the patients who develop second NSCLCs tend to have early-stage NSCLC (predominantly stage I and II). The survival of patients after the second resection of lung cancer is similar to that of patients presenting with initial NSCLC. The risk of second lung cancers in patients surviving SCLC is 2% to 14% per patient per year and increases two- to seven-fold with the passage of time from 2 to 10 years. The risk of second lung cancers in patients treated for SCLC appears to be higher than that found in patients with NSCLC who were treated only with surgical resection. In addition, the chances of successful resection of second primary NSCLCs in patients who were treated for SCLC is much less than that for patients with metachronous lung cancers after an initial NSCLC. Patients treated for SCLC who continue to smoke cigarettes increase their rate of developing second lung cancers. The contribution of chest radiation and chemotherapy administration to the risk of developing second lung tumors remain to be defined but may be responsible for some of the increased risk in patients treated for SCLC compared to patients undergoing a surgical resection for NSCLC.

  8. Curative Observation of Combining Stewed Gegen Fuling Decoction and Physical Therapy to Treat Acute Enteritis%煨葛根茯苓汤联合物理疗法治疗急性肠炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    赵恒刚; 蔡芳

    2016-01-01

    Objective:To evaluate clinical effect of Stewed Gegen Fuling Decoction combined with physical therapy in the treatment of enteritis.Methods:In July 2012to July 2014in our hospital accepted treatment of 80cases of colitis patients as the research objects,according to the random number were divided into controlled group and observation group,40cases in each group,for the controlled group were treated with physical therapy treatment,the observation group was given Stewed Gegen Fuling Decoction on the basis of the controlled group,the clinical curative effect of the two groups were observed and compared.Results:(1)In the observation group,26cases markedly effective,effective in 12cases,the total efficiency was as high as 95%,significantly better than the controlled group of 67.5%,a significant difference between the two groups,(P<0.05);(2) To observe the integrals of groups of patients with colonoscopy reduced more obvious,significantly faster than the patients in the controlled group,the comparison between the two groups was significant difference,P<0.05.Conclusion:Using Stewed Gegen Fuling Decoction combined with physical therapy treatment can significantly improve treatment effect in patients with colitis,can optimize the quality of life,worthy of promotion.%目的:观察煨葛根茯苓汤联合物理疗法治疗肠炎的临床效果.方法:将2012年7月~2014年7月于我院接受治疗的80例结肠炎患者作为研究对象,按照随机数字法将其分为对照组与观察组各40例,对对照组患者应用物理疗法治疗方案,对观察组则在对照组基础上加用煨葛根茯苓汤联合治疗,对比观察两组患者的临床治疗效果.结果:①观察组显效26例,有效12例,总有效率高达95.0%,明显优于对照组的67.5%,组间对比差异显著,P<0.05;②与对照组比较,观察组患者血清IL-8、SIL-2R及TNF-A水平较低(P<0.05),提示观察组治疗效果更明显.结论:对结肠炎患者采用煨葛根茯苓

  9. A Curative Effect Study on Auricular Seed-pressing Therapy Used for Patients with Insomnia%耳穴贴压治疗失眠症患者的疗效观察

    Institute of Scientific and Technical Information of China (English)

    臧镭镭; 胡虹

    2014-01-01

    Objective To observe the effect of auricular seed-pressing for patients with insomnia. Methods 120 patients with insomnia were randomly divided into three groups, each group of 40 cases, are treated with single medication, single auricular seed-pressing and combined with auricular seed-pressing and medication. Results Combined with auricular seed-pressing and medication group in all aspects of indicators are better than the single medication group and single auricular seed-pressing group. Conclusion Combined with auricular seed-pressing and medication treats the insomnia curative effect to be remarkable.%目的:观察耳穴贴压治疗失眠症患者的疗效。方法失眠症患者120例随机分为三组。每组40例,分别给予单纯服药,单纯耳穴贴压及服药联合耳穴贴压。结果服药联合耳穴贴压组在各方面指标均优于单纯服药组和单纯耳穴贴压组。结论服药联合耳穴贴压治疗失眠症疗效显著。

  10. Metallic taste in cancer patients treated with chemotherapy

    NARCIS (Netherlands)

    Ijpma, I.; Renken, R. J.; ter Horst, G. J.; Reyners, A. K. L.

    Background: Metallic taste is a taste alteration frequently reported by cancer patients treated with chemotherapy. Attention to this side effect of chemotherapy is limited. This review addresses the definition, assessment methods, prevalence, duration, etiology, and management strategies of metallic

  11. Metallic taste in cancer patients treated with chemotherapy

    NARCIS (Netherlands)

    Ijpma, I.; Renken, R. J.; ter Horst, G. J.; Reyners, A. K. L.

    2015-01-01

    Background: Metallic taste is a taste alteration frequently reported by cancer patients treated with chemotherapy. Attention to this side effect of chemotherapy is limited. This review addresses the definition, assessment methods, prevalence, duration, etiology, and management strategies of metallic

  12. Hearing Loss in Patients with Shunt-Treated Hydrocephalus

    Directory of Open Access Journals (Sweden)

    Panova Margarita V.

    2015-12-01

    Full Text Available Hearing loss is a common manifestation of the long-term complications in patients with shunt treated hydrocephalus along with motor development disturbance, cognitive and visual impairment, epilepsy and endocrine disorders.

  13. 肩胛松动术对类风湿患者肩关节功能障碍疗效的观察%Observation of Curative Effect of Scapular Manipulation to Shoulder Joint Dysfunction in Patients with Rheumatoid

    Institute of Scientific and Technical Information of China (English)

    李莉; 赵红

    2016-01-01

    Objective:Rheumatoid arthritis is an autoimmune disease.If the patients are in the conventional treatment at the same time with shoulder chest wall joint mobilization rehabilitation treatment, can effectively improve shoulder joint dysfunction, shorten the treat-ment time, improve the quality of life.Objective: To observe curative effect of shoulder joint dysfunction with the shoulder blade chest wall joint mobilization in patients with rheumatoid.Methods:78 patients with rheumatoid arthritis in December 2004 to April 2005 were randomly divided into intervention group( 38 cases) and control group (40 cases).After 1-2 period of treatment, effects were assessed through the shoulder joint function and clinical curative effect.To observe the curative effecthe of scapular manipulation in patients with rheumatoid disorders.Results:the intervention group 29 cases, 7cases effectively, the total effective rate was 94.7%, curative effect is significant difference (P <0.05) which compared with the control group.Conclusion:If the patients are in the conventional treatment at the same time with shoulder chest wall joint mobilization rehabilitation treatment, can effectively improve shoulder joint dysfunction, short-en the treatment time, improve the quality of life.%目的:类风湿关节炎是一种自身免疫疾病,患者在接受常规治疗的同时若配以肩胛胸壁关节松动术为主的康复治疗,能够有效地改善类风湿患者肩关节功能障碍,同时缩短治疗时间,提高患者生活质量。本研究观察肩胛胸壁关节松动术对类风湿患者肩关节功能障碍的疗效。方法:选择2014年12月~2015年4月符合诊断标准的78例类风湿性关节炎患者,采用随机数字表法,分为干预组38例和对照组40例。干预组利用常规治疗药物+蜡疗+肩胛松动术+主动运动;对照组为常规治疗药物+蜡疗+主动运动。治疗1~2个疗程,通过肩关节功能和临床疗效进行

  14. Lacrimal excretory system sequelae in patients treated for leishmaniasis

    OpenAIRE

    Hoyama,Erika; Schellini,Silvana Artioli; Stolf,Hamilton Ometo; Nakajima,Vitor

    2006-01-01

    Leishmaniasis infection may involve destruction of nasal tissues resulting in lacrimal drainage system alteration. PURPOSE: To evaluate the frequency of lacrimal excretory system sequelae in patients treated for leishmaniasis. METHODS: Forty-five leishmaniasis-treated patients (90 nasolacrimal ducts) were submitted to lacrimal excretory system evaluation. All were evaluated by Jones I test and when it was abnormal, dacryocystography and nasal endoscopy were performed. This situation occurred ...

  15. Telomere length and recurrence risk after curative resection in patients with early-stage non-small-cell lung cancer: a prospective cohort study.

    Science.gov (United States)

    Kim, Eric S; Ye, Yuanqing; Vaporciyan, Ara A; Xing, Jinliang; Huang, Maosheng; Gu, Jian; Roth, Jack A; Lippman, Scott M; Wu, Xifeng

    2015-02-01

    We hypothesized that telomere length in peripheral blood would have significant predictive value for risk of recurrence after curative resection in non-small-cell lung cancer (NSCLC). This prospective study included 473 patients with histologically confirmed early stage NSCLC who underwent curative therapy at MD Anderson Cancer Center between 1995 and 2008. Relative telomere length (RTL) of peripheral leukocytes was measured by real-time polymerase chain reaction. The risk of recurrence was estimated as hazard ratios (HRs) and 95% confidence intervals (CIs) using a multivariable Cox proportional hazard regression model. Median duration of follow-up was 61 months, and 151 patients (32%) had developed recurrence at time of analysis. Patients who developed recurrence had significantly longer mean RTL compared with those without recurrence (1.13 versus 1.07, p = 0.046). A subgroup analysis indicates that women had longer RTL compared with men (1.12 versus 1.06, p = 0.025), and the patients with adenocarcinoma demonstrated longer RTL compared with those with other histologic types (1.11 versus 1.05, p = 0.042). To determine whether longer RTL in women and adenocarcinoma subgroup would predict risk of recurrence, multivariate Cox analysis adjusting for age, sex, stage, pack year and treatment regimens was performed. Longer telomeres were significantly associated with higher risk of developing recurrence in women (hazard ratio [HR], 2.25; 95% confidence interval [CI], 1.02-4.96, p = 0.044) and adenocarcinoma subgroups (HR, 2.19; 95% CI, 1.05-4.55, p = 0.036). The increased risk of recurrence due to long RTL was more apparent in women with adenocarcinoma (HR, 2.67; 95% CI, 1.19-6.03, p = 0.018). This is the first prospective study to suggest that long RTL is associated with recurrence in early stage NSCLC after curative resection. Women and adenocarcinoma seem to be special subgroups in which telomere biology may play an important role.

  16. Curating the Poster

    DEFF Research Database (Denmark)

    Christensen, Line Hjorth

    2017-01-01

    structures can work as guidelines for curating posters and graphic design in a museum context. By applying an ecological view to design, specifically the semiotic notion “counter-ability”, it stresses the reciprocal relationship of humans and their built and product-designed environments. It further suggests...... the ecological approach to be viable for curatorial work, and demonstrates how this view inspired a recent poster event, the exhibition Spot on! British posters from the interwar years. The exhibition held at the Danish Poster Museum in 2015-2016 was initiated by the author and co-curated with graphic designer...... Michael Jensen. Keywords: poster, graphic design, environments, exhibition, curating...

  17. An observation of curative effect on cervical nonmalignant abnormity which treated by kangfuxin liquid and fujieshuan cooperating with microwave%康复新液联合妇洁栓辅助微波治疗子宫颈良性异常的疗效观察

    Institute of Scientific and Technical Information of China (English)

    范湘玲; 郭金利; 刘燕

    2011-01-01

    目的 观察子宫颈良性异常微波治疗后,应用康复新液联合妇洁栓对宫颈创面愈合的疗效.方法 460例宫颈良性异常患者,随机分为2组,每组230例.治疗组微波治疗后阴道联合应用康复新液、妇洁栓,对照组仅作微波治疗,观察两组治疗后宫颈创面愈合、阴道排液、出血等情况.结果 12周末时治疗组、对照组一次治愈率分别为97.39%、90.43%,两组比较有显著性差异(P<0.05);治疗组第1、2周的脱痂过程短,术后2、3、4周上皮覆盖过程明显优于对照组,两组有极显著性差异(P<0.01).治疗组阴道排液量明显减少,平均排液时间18d,对照组30d;治疗组阴道平均出血时间(8.13±2.31)d,对照组(14.67±2.95)d,两组比较均有显著性差异(P<0.05).结论 子宫颈良性异常微波治疗后,应用康复新液联合妇洁栓对减少阴道排液、出血及创面的修复起到了积极的作用,简便易行,疗效可靠.%Objective To observe curative effect of cervical nonmalignant abnormity which treated by kangfuxin liquid and fujieshuan (adsorption of vaginal inflammation suppository )cooperating with microwave. Methods Vaginas of patients in treating group were stuffed cotton ball with tail which dipped by kangfuxin liquid and 0.5% iodophor after cervical nonmalignant abnormity having been cured by microwave, and used them everynight for 12 days. Observe concrescence of cervix and bad reaction. Results Once curative ratio of treating group was 97.39% untill the end of the 12th week after curing, and that of control group was 90.43%. There were difference between two groupo(P < 0.05). It was short that decrustation after one week and two week in treating group; Epidermic bestrows in treating group were better obviously than those in control group after two week and three week and four week after curing. There were significant difference between two groups (P < 0.01 ). The number of the liquid flowing from vagina in treating

  18. 高压氧治疗儿童病毒性脑炎的效果分析%The curative effects of hyperbaric oxygen on treating children with viral meningitis

    Institute of Scientific and Technical Information of China (English)

    曾彦; 罗一峰

    2014-01-01

    Objective To investigate the curative effects of hyperbaric oxygen on treating children with viral meningitis.Methods 92 children with viral meningitis from October 2012 to October 2013 in our hospital were randomly divided into the observation group (n=46) and the control group (n=46). The control group was treated with conventional basic treatment measures ,and the observation group was treated with conventional treatment combined with hyperbaric oxygen measures. Re-sults The aphasia improve time ,facial paralysis improve time ,limb paralysis improve time and total treatment efficiency of ob-servation group were better than these of control group. Conclusion Hyperbaric oxygen therapy has a better curative effect on treating children with viral meningitis ,which is worthy of clinic application.%目的:探讨高压氧治疗儿童病毒性脑炎的临床疗效,为临床相关研究提供借鉴和参考。方法儿童病毒性脑炎患者92例随机将患儿分为对照组和观察组各46例。对照组采用常规基础治疗,观察组加用高压氧治疗。结果(1)2组失语改善时间、面瘫改善时间、肢瘫改善时间比较,观察组均显著优于对照组,差异有计学意义(P均<0.05);(2)观察组总有效率显著高于对照组,差异有统计学意义(χ2=6.4519,P=0.0111)。结论与常规治疗方法比较,高压氧治疗儿童病毒性脑炎患儿疗效显著,是临床治疗儿童病毒性脑炎的理想选择。

  19. Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens

    Science.gov (United States)

    Win, Htun Htun; Thitipanawan, Niramon; Po, Christina; Chowwiwat, Nongnud; Raksapraidee, Rattanaporn; Wilairisak, Pornpimon; Keereecharoen, Lily; Proux, Stéphane

    2017-01-01

    Background Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD heterozygous females, because of individual variation in the pattern of X-chromosome inactivation (Lyonisation) in erythroid cells, may have low G6PD activity in the majority of their erythrocytes, yet are usually reported as G6PD “normal” by current phenotypic screening tests. Their haemolytic risk when treated with 8-aminoquinolines has not been well characterized. Methods and Findings In a cohort study nested within a randomised clinical trial that compared different treatment regimens for P. vivax malaria, patients with a normal standard NADPH fluorescent spot test result (≳30%–40% of normal G6PD activity) were randomised to receive 3 d of chloroquine or dihydroartemisinin-piperaquine in combination with primaquine, either the standard high dose of 0.5 mg base/kg/day for 14 d or a higher dose of 1 mg base/kg/d for 7 d. Patterns of haemolysis were compared between G6PD wild-type and G6PD heterozygous female participants. Between 21 February 2012 and 04 July 2014, 241 female participants were enrolled, of whom 34 were heterozygous for the G6PD Mahidol variant. Haemolysis was substantially greater and a larger proportion of participants reached the threshold of clinically significant haemolysis (fractional haematocrit reduction >25%) in G6PD heterozygotes taking the higher (7 d) primaquine dose (9/17 [53%]) compared with G6PD heterozygotes taking the standard high (14 d) dose (2/16 [13%]; p = 0.022). In heterozygotes, the mean fractional haematocrit reductions were correspondingly greater with the higher primaquine dose (7-d regimen): −20.4% (95% CI −26.0% to −14.8%) (nadir on day 5) compared with the standard high (14 d) dose: −13.1% (95% CI −17.6% to −8.6%) (nadir day 6). Two heterozygotes taking the higher (7 d) primaquine dose

  20. The Future for Curators

    Directory of Open Access Journals (Sweden)

    Elise Coralie Edwards

    2007-11-01

    Full Text Available The role of the curator has changed and is likely to change in the future. Current issues of postmodernism have affected their authority and status, by calling on new voices and narratives. Criticisms continue to be levelled at curators for failing to change communication through display and to maintain subject-based expertise, while new technology constantly increases both the demand for and the supply of information. A survey of curatorial jobs in the 'Museums Journal 'confirms that the level of skills and knowledge required of curators has decreased. These changes will continue, as in the future curators will be affected by changes in technology, new computerised applications and competition for funding.

  1. Health status in patients treated with cardiac resynchronization therapy

    DEFF Research Database (Denmark)

    Schiffer, Angélique A; Denollet, Johan; Pedersen, Susanne S.

    2008-01-01

    Cardiac resynchronization therapy (CRT) is a promising treatment in chronic heart failure (CHF). However, a subgroup of patients still report impaired health status, cardiac symptoms, and feelings of disability following CRT. The aims of this study were to examine (1) whether CHF patients treated...

  2. Cognitive function in patients with chronic pain treated with opioids

    DEFF Research Database (Denmark)

    Kurita, G P; de Mattos Pimenta, C A; Braga, P E

    2012-01-01

    The paucity of studies regarding cognitive function in patients with chronic pain, and growing evidence regarding the cognitive effects of pain and opioids on cognitive function prompted us to assess cognition via neuropsychological measurement in patients with chronic non-cancer pain treated...

  3. Psychological functioning in cancer patients treated with radiotherapy

    NARCIS (Netherlands)

    Stiegelis, HE; Ranchor, AV; Sanderman, R

    2004-01-01

    Although many side-effects of radiotherapy (RT) are physical, previous studies have shown that patients, when treated with RT, also experience psychological problems. This review describes the psychological functioning of cancer patients prior to, during, and after RT. Moreover, we examined whether

  4. 酚妥拉明与多巴酚丁胺治疗慢性肺心病重度心衰的疗效观察%The observation of the curative offects on 26cases about treating the acute tert failure of the chronic pulmonary heart disease with Phentolamine and Dobutamine

    Institute of Scientific and Technical Information of China (English)

    张福财

    2001-01-01

    Objectives To study the curative effects about treating the acute heart failure of the chronic pulmonary heart disease with Phentolamine and Dobutamine.Methods Based on the integrated treatment,the treatment of the 26 patients who suffered from the acute heart failure of the chronic pulmonary heart disease was co-operatively dealt with by Phentolamine and Dobutamine.Results  After the curative courses enden,the total rate of the effect of the treatment group was 92.1%,while that of the control group was 67.0%.There was a very obvious significance(P<0.01).The former have some obvious effect on Grade IV heart function,significantly shorten the time of improving the heart function(P<0.05),resist the irregularity in the rhythem of the heart's beating and also stabilize the blood pressure and the heart rate(P>0.05).Conclusions Phentolamine and dobutamine are the safe and effective medicines which can be used to treat the acute heart failure of the chronic pulmonary heart disease with very good curative effects and without any side effects.%目的探讨酚妥拉明与多巴酚丁胺在肺心病重度心衰中的疗效。方法对26例肺心病重度心衰患者在综合治疗的基础上,应用酚妥拉明与多巴酚丁胺进行联合治疗。结果疗程结束后,治疗组总有效率为92.1%,对照组为67.0%,两组疗效有非常显著性差异(P<0.01)。前者对心功能Ⅳ级有显著疗效,心功能改善时间显著缩短(P<0.05),且有抗心律失常作用,对血压、心率有稳定(P>0.05)作用。结论酚妥拉明与多巴酚丁胺是治疗肺心病重度心衰安全有效的药物,疗效高,副作用少。

  5. Curating a Mild Apocalypse

    DEFF Research Database (Denmark)

    Brichet, Nathalia Sofie; Hastrup, Frida

    2017-01-01

    On the basis of our exhibition “Mild Apocalypse. Feral Landscapes in Denmark” (2016) we discuss how we curated insights generated in a collaborative cross-disciplinary research project about a former mining site in Denmark. We approach this industrially disturbed and radically altered landscape......-based curating must follow suit by creating novel objects, thereby making exhibitions into provisional analyses and blurring conventional lines between art galleries and museums of cultural history....

  6. High dose rate endobronchial brachytherapy: a curative treatment; La curietherapie endobronchique de haut debit de dose: un traitement curatif

    Energy Technology Data Exchange (ETDEWEB)

    Peiffert, D.; Spaeth, D.; Winnefeld, J. [Centre Alexis-Vautrin, 54 - Vandoeuvre-les-Nancy (France); Menard, O. [Centre Hospitalier Universitaire Nancy-Brabois, 54 - Vandoeuvre-les-Nancy (France)

    2000-06-01

    New endobronchial techniques of treatment allow a good unblocking. Nevertheless, only high dose rate brachytherapy delivers a curative treatment for invasive carcinomas. This study analyses the results of the first 33 consecutive patients treated with curative intent by this technique from 1994 to 1997, and followed-up more than one year. Thirty-seven lesions were treated, with usual schedule delivering 30 Gy at 1 cm depth in six fractions and three to five weeks. All the patients were meticulously selected on the local involvement of the tumour and absolute contraindications to a surgical treatment. All of them have a pulmonary disease history or a general contraindication. With a 14-month follow-up, the local control at two months after the treatment was 95 % (endoscopic and histologic), and 90 % of the patients presented a prolonged local control. Four patients died of the treated cancer, another of a controlateral cancer. Ten patients died of another disease, five of them from a respiratory insufficiency. The overall survival rate at two years was 53 % and the specific survival rate 80 %. The acute tolerance was good, without incident. Asymptomatic bronchial stenoses, described by endoscopic follow-up, were described for seven patients. We conclude that, on the basis of a good selection of the patients, and a respect of the indications, high dose rate endobronchial brachytherapy is an effective curative treatment. It offers a new curative option and must be proposed for the small invasive carcinomas in non-operable patients. (author)

  7. Curative Effect Observation of Cosmetic Incision along with the Axillary Dermatoglyph in the Treatment of 56 Patients with Bromhidrosis%顺腋窝皮纹美容切口治疗腋臭56例疗效观察

    Institute of Scientific and Technical Information of China (English)

    邹普功; 李长明; 王剑

    2015-01-01

    Objective To investigate and summarize the curative effect of cosmetic incision along with axillary dermatoglyph in the treatment of bromhidrosis. Methods Fifty⁃six patients with bromhidrosis of different degrees admitted between March, 2012 and February, 2013 were treated with cosmetic incision along with axillary dermatoglyph after the top⁃ical anesthesia, in combination with scraping or scissoring off the local sweat glands, fat globules and sudoriferous ducts with curet or eye scissors. The curative effects were observed. Results Three patients of the 56 patients developed hematoma post⁃incision, of which, 2 patients were given hematoma resection 48 hours post⁃incision and the wound healed after strengthened dressing changes, while the other one patient developed skin necrosis in the center of axilla at a size of 1 cm × 1. 5 cm and the necrotic wound healed after the debridement and suture 7 days post⁃incision. The incisions of all the other patients got healed satisfyingly. The three⁃month follow⁃up showed the incision wounds of all the patients recovered excel⁃lently with no hypertrophic scar formation. All patients no longer had smell except three patients still with mild odors. Con⁃clusion Cosmetic incision along with axillary dermatoglyph in the treatment of bromhidrosis can realize satisfying curative effects, in addition to its simple and easy operation, higher patients’ satisfaction, deserving to be promoted in clinic.%目的:探讨总结顺腋窝皮纹美容切口治疗腋臭的临床疗效。方法对2012年3月-2013年2月就诊的56例不同程度的腋臭患者,在局部肿胀麻醉下顺腋窝皮纹做美容切口,并用腋臭刮匙刮除或眼科剪剪除局部汗腺、脂肪球及汗腺导管,观察治疗效果。结果56例患者中,3例患者术后出现血肿,但其中2例患者于术后48 h清除血肿并加强换药后未影响伤口愈合;1例患者腋窝中央皮肤坏死,面积约1 cm ×1.5 cm

  8. Observation of Curative Effect of Gangliosides Combine with Edaravone Treating Acute Cerebral Infarction of Old People%神经节苷脂联合依达拉奉治疗老年人急性脑梗死疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨醒鸿; 李焕生; 周丛斌; 颜国平

    2015-01-01

    Objective Ti ibserve the curative effect if gangliisides cimbine with edaravine treating acute cerebral infarctiin if ild pei-ple. Method 120 cases if patients with acute cerebral infarctiin were randim divided inti the Treating griup(gangliisides cimbine with edaravine treating griup )and Cintril griup(riutine treating griup),60 cases in each griup,the twi griup's patients' clinical effective rate and Natiinal Institutes if Health Strike Scale(NIHSS)grade level changes situatiin were ibserved and cimpared. Results The patients in the treating griup had higher than the cintril griup,the differences were statistically significant(p ﹤0. 05). The clinical effective rate if pa-tients if the twi griups' pre - treatment NIHSS scale had ni statistically significant difference(p ﹥ 0. 05),after treating fir 14 d,the treat-ment griup's patients had liwer NIHSS scale than the cintril griup,the differences were statistically significant(p ﹤0. 05). Ni adverse reac-tiin if cerebral hemirrhage and si in iccur in the treating pricess. Conclusion Gangliisides cimbine with edaravine treating acute cerebral infarctiin if ild peiple,it has satisfied clinical curative effect,it is safe and reliable,and it is wirth clinical applicatiin.%目的:观察神经节苷脂联合依达拉奉治疗老年人急性脑梗死的临床治疗效果。方法:将120例老年人急性脑梗死患者,随机分为治疗组(神经节苷脂联合依达拉奉治疗组)和对照组(常规治疗组),每组患者各60例,观察比较两组患者的临床总有效率及神经功能缺损量表(NIHSS)评分程度变化情况。结果:治疗组患者的临床总有效率较对照组明显提高,差异有统计学意义(p ﹤0.05)。两组患者治疗前 NIHSS 评分差异无统计学意义(p ﹥0.05),治疗14 d 后治疗组患者的 NIHSS 评分较对照组明显下降,差异具有统计学意义(p ﹤0.05)。治疗过程中未见脑出血等不良反应发生。结

  9. Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related hepatocellular carcinoma: a retrospective cohort study at two centers in China

    Science.gov (United States)

    Li, De-Wei; Fan, Jia; Zhou, Jian; Feng, Gen-Sheng; Qiu, Shuang-Jian; Du, Cheng-You

    2017-01-01

    Although Metavir and Fibrosis-4 (FIB-4) scores are typically used to assess the severity of liver fibrosis, the relationship between these scores and patient outcome in hepatocellular carcinoma (HCC) is unclear. The aim of this study was to evaluate the prognostic value of the severity of hepatic fibrosis in HBV-related HCC patients after curative resection. We examined the prognostic roles of the Metavir and preoperative FIB-4 scores in 432 HBV-HCC patients who underwent curative resection at two different medical centers located in western (Chongqing) and eastern (Shanghai) China. In the testing set (n = 108), the Metavir, FIB-4, and combined Metavir/FIB-4 scores were predictive of overall survival (OS) and recurrence-free survival (RFS). Additionally, they were associated with several clinicopathologic variables. In the validation set (n = 324), the Metavir, FIB-4, and combined Metavir/FIB-4 scores were associated with poor prognosis in HCC patients after curative resection. Importantly, in the negative alpha-fetoprotein subgroup (≤ 20 ng/mL), the FIB-4 index (I vs. II) could discriminate between patient outcomes (high or low OS and RFS). Thus Metavir, preoperative FIB-4, and combined Metavir/FIB-4 scores are prognostic markers in HBV-HCC patients after curative hepatectomy. PMID:27662665

  10. 祛瘀接骨丸治疗骨折临床观察%Observation of the Curative Effect of Quyujiegu Pill on Treating 42 cases of Fractures

    Institute of Scientific and Technical Information of China (English)

    孙权; 唐孝富

    2012-01-01

    目的 观察祛瘀接骨丸治疗骨折的疗效.方法 将患者随机分为两组,治疗组予祛瘀接骨丸内服、外敷治疗,对照组口服碳酸钙片;每疗程15d,共治3个疗程.结果 两组均获临床愈合,均未见明显毒副作用,治疗组临床愈合时间明显短于对照组.结论 祛瘀接骨丸治疗骨折,能促进骨折愈合,有效缩短临床愈合时间,具有较好临床价值.%Objective: To observe the clinical effect of Quyu Jiegu Pill in the treatment of fracture. Methods: All cases were randomly divided into treatment group that treated with Quyu Jiegu Pill and control group that treated with Calcium carbonate tablets; the cases were treated with 3 courses of treatment and one course of treatment was 15 days. Results: Two groups of the fractures all healed without side effect,the treatment group needed less clinical time for fracture union than the control group. Conclusion: Quyujiegu Pill can promote the fracture healing and shorten the clinical healing time of fracture. It has good clinical application value.

  11. Antierythropoietin Antibodies in Hemodialysis Patients Treated with Recombinant Erythropoietin

    OpenAIRE

    Savaş ÖZTÜRK; Alper GÜMÜŞ; Vecihi MEMİLİ; Muhammet Emin DÜZ; Egemen CEBECİ; Macit KOLDAŞ; Rümeyza KAZANCIOĞLU

    2014-01-01

    OBJECTIVE: Erythropoietin resistance is a serious problem in patients treated with recombinant erythropoietin. Antierythropoietin antibodies are considered to be one of the causes of this resistance. MATERIAL and ME THODS: We investigated antierythropoietin antibodies in chronic hemodialysis patients and compared the results with healthy controls by means of establishing an ELISA method. A total of 121 chronic hemodialysis patients receiving recombinant erythropoietin were included in the ...

  12. Craniofacial morphology in Turner syndrome patients treated with growth hormone

    Directory of Open Access Journals (Sweden)

    Jovana Julsoki

    2015-05-01

    Full Text Available ABSTRACT Introduction: In addition to well-established physical characteristics, Turner syndrome patients have distinct craniofacial morphology. Since short stature is the most typical characteristic, Turner syndrome patients are commonly treated with growth hormone in order to increase final height. At the same time, growth hormone treatment was found to influence craniofacial growth and morphology in various groups of treated patients. Whereas craniofacial characteristics of Turner syndrome patients are well documented, comparatively little is known of craniofacial morphology of those who are treated with growth hormone. Aim: The aim of this study was to investigate craniofacial morphology in Turner syndrome patients treated with growth hormone in comparison to healthy females. Materials and methods: The cephalometric evaluation was conducted on twenty lateral cephalograms of Turner syndrome patients (13.53 ± 4.04 years treated with growth hormone for at least one year (4.94 ± 1.92 years in average. As a control group, forty lateral cephalograms of healthy female controls, who matched Turner syndrome patients by chronological (11.80 ± 2.37 years and skeletal age, were used. Eleven angular, seven linear measurements and six dimensional ratios were measured to describe craniofacial morphology. Results: The results obtained for angular measurements, in cephalometric analyses for Turner syndrome patients treated with growth hormone, revealed bimaxillary retrognathism. The linear measurements indicated longer mandibular ramus, anterior cranial base and both anterior and posterior facial heights. However, posterior cranial base and maxilla were in proportion to the anterior cranial base, when comparing dimensional ratios. Anterior cranial base, maxilla and mandibular ramus were larger in proportion to mandibular body; as well as posterior facial height was when compared to anterior facial height. Turner syndrome patients treated with growth

  13. Intrahepatic Flow Redistribution in Patients Treated with Radioembolization

    Energy Technology Data Exchange (ETDEWEB)

    Spreafico, Carlo, E-mail: carlo.spreafico@istitutotumori.mi.it; Morosi, Carlo, E-mail: carlo.morosi@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Radiology (Italy); Maccauro, Marco, E-mail: marco.maccauro@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Nuclear Medicine (Italy); Romito, Raffaele, E-mail: raffaele.romito@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Liver Surgery and Transplant (Italy); Lanocita, Rodolfo, E-mail: rodolfo.lanocita@istitutotumori.mi.it; Civelli, Enrico M., E-mail: enrico.civelli@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Radiology (Italy); Sposito, Carlo, E-mail: carlo.sposito@istitutotumori.mi.it; Bhoori, Sherrie, E-mail: sherrie.bhoori@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Liver Surgery and Transplant (Italy); Chiesa, Carlo, E-mail: carlo.chiesa@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Nuclear Medicine (Italy); Frigerio, Laura F., E-mail: laura.frigerio@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Radiology (Italy); Lorenzoni, Alice, E-mail: alice.lorenzoni@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Nuclear Medicine (Italy); Cascella, Tommaso, E-mail: tommaso.cascella@istitutotumori.mi.it; Marchianò, Alfonso, E-mail: alfonso.marchiano@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Radiology (Italy); Mazzaferro, Vincenzo, E-mail: vincenzo.mazzaferro@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Liver Surgery and Transplant (Italy)

    2015-04-15

    IntroductionIn planning Yttrium-90 ({sup 90}Y)-radioembolizations, strategy problems arise in tumours with multiple arterial supplies. We aim to demonstrate that tumours can be treated via one main feeding artery achieving flow redistribution by embolizing accessory vessels.MethodsOne hundred {sup 90}Y-radioembolizations were performed on 90 patients using glass microspheres. In 19 lesions/17 patients, accessory branches were found feeding a minor tumour portion and embolized. In all 17 patients, the assessment of the complete perfusion was obtained by angiography and single photon emission computerized tomography–computerized tomography (SPECT–CT). Dosimetry, toxicity, and tumor response rate of the patients treated after flow redistribution were compared with the 83 standard-treated patients. Seventeen lesions in 15 patients with flow redistribution were chosen as target lesions and evaluated according to mRECIST criteria.ResultsIn all patients, the complete tumor perfusion was assessed immediately before radioembolization by angiography in all patients and after the {sup 90}Y-infusion by SPECT–CT in 15 of 17 patients. In the 15 assessable patients, the response rate in their 17 lesions was 3 CR, 8 PR, and 6 SD. Dosimetric and toxicity data, as well tumour response rate, were comparable with the 83 patients with regular vasculature.ConclusionsAll embolization procedures were performed successfully with no complications, and the flow redistribution was obtained in all cases. Results in term of toxicity, median dose administered, and radiological response were comparable with standard radioembolizations. Our findings confirmed the intratumoral flow redistribution after embolizing the accessory arteries, which makes it possible to treat the tumour through its single main feeding artery.

  14. 针灸结合心理疗法治疗失眠症57例疗效观察%Curative Effect Observation of the Treatment of Acupuncture Combined with Py-schological Cure for 57 Patients with Insomnia

    Institute of Scientific and Technical Information of China (English)

    王永红

    2014-01-01

    Objective:To observe the curative effect of treatment of acupuncture combined with psychological cure for the patients with insomnia. Method:57 cases with insomnia were treated by the method of acupuncture combined with pyschological cure. The effect was analyzed. Result:The effective rate was 97% after the acupunture treatment for 1 to 3 months and the psychological cure for 3 to 9 months. Conclusion:The acupuncture combined with pyschological cure is effective treatment for the patients with insomnia.%目的:观察针灸结合心理疗法治疗失眠症效果。方法:对57例失眠患者行针灸结合心理疗法治疗,并做分析总结。结果:患者经1~3个疗程针灸治疗和3~9次心理疗法治疗,有效率97%。结论:针灸结合心理疗法治疗失眠症是一种有效的方法。

  15. Curative to palliative care-transition and communication issues: Surgeons perspective

    Directory of Open Access Journals (Sweden)

    S V Suryanarayana Deo

    2013-01-01

    Full Text Available Transition of a cancer patient from curative to palliative stage is one of the most difficult and challenging phases of cancer care both from patient and physician point of view. Most of the time the treating surgeons are expected to facilitate this transition but due to a number of reasons surgeons often fail to fulfill this crucial responsibility. This article highlights the various issues involved in the transition phase from a surgeons perspective.

  16. Curative to palliative care-transition and communication issues: surgeons perspective.

    Science.gov (United States)

    Suryanarayana Deo, Sv; Thejus, T

    2013-05-01

    Transition of a cancer patient from curative to palliative stage is one of the most difficult and challenging phases of cancer care both from patient and physician point of view. Most of the time the treating surgeons are expected to facilitate this transition but due to a number of reasons surgeons often fail to fulfill this crucial responsibility. This article highlights the various issues involved in the transition phase from a surgeons perspective.

  17. Tetany in kala azar patients treated with paromomycin.

    Science.gov (United States)

    Thakur, C P

    2008-05-01

    Paromomycin, an aminoglycoside, is known to cause several side effects like nephrotoxicity and ototoxicity like other aminoglycosides but tetany has not been reported. Three cases of tetany were detected in the patients of kala-azar treated with paromomycin. They were promptly treated with intravenous 10 per cent calcium gluconate and tetany was relieved immediately and treatment with paromomycin continued with oral calcium supplement. After completion of 21 days treatment with paromomycin patients' splenic aspirates were free of parasites. Paromomycin may cause temporary tubular damage leading to calcium wasting in urine and hypocalcaemia resulting in tetany. Prompt detection of symptoms and intravenous calcium gluconate treatment promptly reverse the situation.

  18. 阿魏酸钠治疗糖尿病周围神经病变的疗效观察%Observation about the clinical curative effect of sodium ferulate in treating diabetic peripheral neuropathy

    Institute of Scientific and Technical Information of China (English)

    杨祖蓉

    2012-01-01

    Objective To observe the clinical curative effect of sodium ferulate in treating diabetic peripheral neuropathy. Methods 75 inpatients with diabetic peripheral neuropathy were given conventional treatment , diabetes education , sports and diabetic diet with strict control of blood glucose . At the same time , their original treatment were not changed without other anticoagulants , vasodilators and neurotrophic drugs . The 75 inpatients with diabetic peripheral neuropathy were selected and randomly divided into 2 groups : treatment group (n =45) and control group (n =30) . The treatment group were given intravenously 0. 3 sodium ferulate per day for 20 days , and the control group were given a daily intramuscular injection of vitamin B1 10mg and vitamin B12 0. 5mg for 20 days . At last we had a comparison of the therapeutic effect . Results The symptoms and signs of the treatment group than of the control group were improved significantly different ; EMC nerve test showed that the treatment group before and after treatment had significant changes in conduction velocity than the control group improved significantly . Conclusion It is of exact curative to treat diabetic peripheral neuropathy with sodium ferulate .%目的 观察阿魏酸钠治疗糖尿病周围神经病变的疗效.方法 将75例糖尿病周围神经病变患者常规给予基础治疗,糖尿病教育、运动及糖尿病饮食,并运用口服药物和胰岛素严格控制血糖,原治疗措施不变,停用其它抗凝剂、扩血管药及营养神经药物.随机分成治疗组45例,给予阿魏酸钠0.3g静脉滴注1次/d,共20d,对照组30例给予维生素B1和维生素B12,比较其疗效.结果 治疗组症状、体征的改善与对照组相比差异有统计学意义(P<0.05);肌电图检测显示神经传导速度,治疗组治疗前与治疗后有明显变化(P<0.05),明显高于对照组.结论 阿魏酸钠有明显改善糖尿病周围神经病变的疗效.

  19. More Than a Text Message: Dismantling Digital Triggers to Curate Behavior Change in Patient-Centered Health Interventions.

    Science.gov (United States)

    Muench, Frederick; Baumel, Amit

    2017-05-26

    Digital triggers such as text messages, emails, and push alerts are designed to focus an individual on a desired goal by prompting an internal or external reaction at the appropriate time. Triggers therefore have an essential role in engaging individuals with digital interventions delivered outside of traditional health care settings, where other events in daily lives and fluctuating motivation to engage in effortful behavior exist. There is an emerging body of literature examining the use of digital triggers for short-term action and longer-term behavior change. However, little attention has been given to understanding the components of digital triggers. Using tailoring as an overarching framework, we separated digital triggers into 5 primary components: (1) who (sender), (2) how (stimulus type, delivery medium, heterogeneity), (3) when (delivered), (4) how much (frequency, intensity), and (5) what (trigger's target, trigger's structure, trigger's narrative). We highlighted key considerations when tailoring each component and the pitfalls of ignoring common mistakes, such as alert fatigue and habituation. As evidenced throughout the paper, there is a broad literature base from which to draw when tailoring triggers to curate behavior change in health interventions. More research is needed, however, to examine differences in efficacy based on component tailoring, to best use triggers to facilitate behavior change over time, and to keep individuals engaged in physical and mental health behavior change efforts. Dismantling digital triggers into their component parts and reassembling them according to the gestalt of one's change goals is the first step in this development work. ©Frederick Muench, Amit Baumel. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 26.05.2017.

  20. Curative effect observation of patients with primary systemic amyloidosis treated by the combination of bortezomib with dexmethasone and cyclophosphamide

    Institute of Scientific and Technical Information of China (English)

    路瑾

    2013-01-01

    Objective To analyze the efficacy and side effects of the combination regimen containing bortezomib,cyclophosphamide and dexamethasone(BCD)in the treatment of primary systemic amyloidosis(PSA).Methods

  1. Evaluation of Clinical Curative Effect on 142 Patients With Gastric Ulcer%142例胃溃疡病例的临床疗效评价

    Institute of Scientific and Technical Information of China (English)

    王颖

    2015-01-01

    目的:对比分析不同治疗方案治疗胃溃疡的临床疗效。方法选择胃溃疡病例142例,随机分入奥美拉唑联合阿莫西林克拉维酸钾组和奥美拉唑组,每组各72例,选择总有效率为观察指标。结果奥美拉唑联合阿莫西林克拉维酸钾组总有效率95.13%和奥美拉唑组总有效率73.41%,P<0.05,差异具有统计学意义。结论对于胃溃疡的治疗,奥美拉唑联合阿莫西林克拉维酸钾具有更好的临床疗效。%Objective Compare with the curative effect on different treatment protocols of gastric ulcer. Methods Selected 142 patients with gastric ulcer were randomized to the omeprazole combined with amoxicillin group and the omeprazole group, each group had 72 cases. Observation index of total efifciency rate. Results The total efifciency rate was 95.13%in the omeprazole combined with amoxicillin group and 73.41% in the omeprazole group, P<0.05, had difference statistically significance. Conclusion Omeprazole combine with amoxicillin has better clinical curative effect on gastric ulcers.

  2. Hair cortisol measurement in mitotane-treated adrenocortical cancer patients.

    Science.gov (United States)

    Manenschijn, L; Quinkler, M; van Rossum, E F C

    2014-04-01

    The only approved drug for the treatment of adrenocortical cancer (ACC) is mitotane. Mitotane is adrenolytic and therefore, hydrocortisone replacement therapy is necessary. Since mitotane increases cortisol binding globulin (CBG) and induces CYP3A4 activity, high doses of hydrocortisone are thought to be required. Evaluation of hydrocortisone therapy in mitotane-treated patients has been difficult since there is no good marker to evaluate hydrocortisone therapy. Measurement of cortisol in scalp hair is a novel method that offers the opportunity to measure long-term cortisol levels. Our aim was to evaluate whether hair cortisol measurements could be useful in evaluating recent hydrocortisone treatment in mitotane-treated ACC patients. Hair cortisol levels were measured in 15 mitotane-treated ACC patients on hydrocortisone substitution and 96 healthy individuals. Cortisol levels were measured in 3 cm hair segments, corresponding to a period of 3 months. Hair cortisol levels were higher in ACC patients compared to healthy individuals (pcortisol levels above the reference range. None of the patients had hair cortisol levels below normal. In contrast to hydrocortisone doses (β=0.03, p=0.93), hair cortisol levels were associated with BMI (β=0.53, p=0.042). There was no correlation between hair cortisol levels and hydrocortisone doses (β=0.41, p=0.13). Almost half of the ACC patients had high hair cortisol levels, suggesting long-term over-substitution of hydrocortisone in some of the patients, whereas none of the patients was under-substituted. Hair cortisol measurements might be useful in long-term monitoring hydrocortisone treatment in mitotane-treated ACC patients.

  3. Evaluation of the orofacial lesions in treated leprosy patients

    Directory of Open Access Journals (Sweden)

    V K Pooja

    2014-01-01

    Full Text Available Background: Leprosy is primarily a disease of developmental countries. About 4 million people have or are disabled by leprosy. Eighty-six percent of leprosy patients reside in Southeast Asia and Brazil. India accounts for up to 70% of total cases. Aim: To evaluate the incidence of orofacial lesions in treated leprosy patients. Materials and Methods: Thirty treated leprosy patients were examined clinically and the percentage of orofacial lesions were evaluated. Results: On evaluating the orofacial lesions, incidence of hypopigmentation on face and oral mucosa were highest (63% followed by depressed nasal bridge and fissured tongue (33%. The incidence of crenated tongue was seen to be the lowest (3.3%. Conclusion: Orofacial lesions in leprosy patients develop insidiously, generally are asymptomatic and are secondary to nasal changes. Oral lesions may contribute to the diagnosis of the disease and be attributed to involvement of Mycobacterium leprae.

  4. The changing face of HIV/AIDS in treated patients.

    Science.gov (United States)

    Llibre, Josep M; Falco, Vicenç; Tural, Cristina; Negredo, Eugenia; Pineda, Juan A; Muñoz, Jose; Ortega, Enrique; Videla, Sebastia; Sirera, Guillem; Martinez, Esteban; Miralles, Celia; Iribarren, Josean; Galindo, Maria J; Domingo, Pere; d'Arminio-Monforte, Antonella; Miro, Jose M; Clotet, Bonaventura

    2009-07-01

    The spectrum of complications emerging in successfully treated HIV-infected patients has dramatically changed since the advent of HAART. Typical AIDS-defining illnesses have been substituted by new comorbid conditions that threaten even those patients who maintain virologic suppression. Proper management of cardiovascular risk, and early diagnosis of AIDS-related and, particularly, non-AIDS-related malignancies (including papilomavirus-related neoplasms) must be introduced into the routine of care. Hot areas of investigation include HIV-associated neurocognitive disorders, hepatitis B and C coinfection, non-alcoholic fatty liver disease, progressive multifocal leukoencephalopathy and tuberculosis. Bone and kidney long-term toxicities and lipoatrophy remain as issues of paramount importance. The identification and early treatment of immune reconstitution disease is also of major interest, specially in those patients starting their antiretroviral treatment with severe CD4 cell depletion. The present review focuses on these twelve areas of increasing interest for physicians currently facing successfully treated HIV+ patients.

  5. Validation of EORTC and CALGB prognostic models in surgical patients submitted to diagnostic, palliative or curative surgery for malignant pleural mesothelioma.

    Science.gov (United States)

    Sandri, Alberto; Guerrera, Francesco; Roffinella, Matteo; Olivetti, Stefania; Costardi, Lorena; Oliaro, Alberto; Filosso, Pier Luigi; Lausi, Paolo Olivo; Ruffini, Enrico

    2016-08-01

    To assess the trend of our surgical patients affected by malignant pleural mesothelioma (MPM) and submitted to diagnostic/palliative or curative surgical procedures and to validate the European Organisation for Research and Treatment of Cancer (EORTC) prognostic score in our patient population. This is a cohort study of patients submitted to surgery for MPM from January 2007 to December 2013. Primary outcome was overall survival (OS). Univariate and multivariate-adjusted comparisons by EORTC prognostic score for OS were accomplished using Cox method. Adjusted models included the following clinical variables: kind of procedure, smoking habit, asbestos exposure, Charlson's Comorbidity Index (CCI), clinical tumor stage, adjuvant chemotherapy, dyspnoea, chest pain and haematological variables according to the score features. Nomenclature of the surgical procedures matches the International Association for the Study Lung Cancer (IASLC)/International Mesothelioma Interest Group (iMIG). One-hundred sixty-six consecutive cases were collected: the median age at surgery was 73 years and 123 patients (75%) had a history of asbestos exposure. Ninty patients (54%) were submitted to a palliative/diagnostic thoracoscopy, 30 to pleurectomy/decortication (P/D), and 6 to extra-pleural pneumonectomy (EPP). Clinical TNM stages were as follows: 99 (60%) stage I-II, 34 (20%) stage III and 33 (20%) stage IV. The median follow-up (FU) was 19 months [interquartile range (IQR), 9-31 months] and the FU-completeness was 98%. By the end of the study 130 patients died (78%). One- and 3-year OS was 60% and 36%, respectively. Patients submitted to EPP and P/D showed a better survival (P=0.013). Multivariable model showed an independent prognostic value of EORTC score (HR =2.86, PEORTC prognostic index proved to be an independent prognostic factor in our cohort of patients and therefore is a reliable and valid instrument that may be implemented in the daily practice.

  6. Effect of pioglitazone on outcome following curative treatment for hepatocellular carcinoma in patients with hepatitis C virus infection: A prospective study.

    Science.gov (United States)

    Sumie, Shuji; Kawaguchi, Takumi; Kawaguchi, Atsushi; Kuromatsu, Ryoko; Nakano, Masahito; Satani, Manabu; Yamada, Shingo; Okamura, Shusuke; Yonezawa, Yuko; Kakuma, Tatsuyuki; Torimura, Takuji; Sata, Michio

    2015-01-01

    Pioglitazone is an insulin sensitizer used for the treatment of diabetes mellitus (DM). DM with insulin resistance is a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection. We aimed to investigate the effects of pioglitazone on HCC recurrence following treatment in HCV-infected patients. Between 2009 and 2011, 85 HCV-infected HCC patients who underwent curative treatment were enrolled in this prospective study. Among 45 patients with type 2 DM, 27 were administered pioglitazone (pioglitazone group) following treatment. The remaining 58 patients were assigned to the control group. The primary outcome was recurrence-free survival. Changes in insulin resistance and serum adiponectin levels resulting from pioglitazone treatment were also assessed. In the whole analysis (n=85), no significant difference in recurrence-free survival was observed between the pioglitazone and control groups. However, in a spline model analysis of DM patients, a decreased risk of HCC recurrence was associated with increased body weight in patients with a body mass index (BMI) ≥23; this association became significant at BMI ≥24 (hazard ratio=0.17; 95% confidence interval: 0.03-0.95). In addition, significantly decreased homeostasis model assessment for insulin resistance values (P=0.002) and significantly increased serum high-molecular-weight adiponectin levels (Ppioglitazone treatment. Although pioglitazone did not suppress HCC recurrence in the whole analysis, it inhibited HCC recurrence in overweight HCV-infected diabetic patients. Moreover, pioglitazone improved insulin resistance and adipocytokine levels. Thus, pioglitazone may suppress HCC recurrence, which is associated with glucose and fat metabolism disorders.

  7. Polyarthritis flare in patient with ankylosing spondylitis treated with infliximab

    Directory of Open Access Journals (Sweden)

    E. Filippucci

    2011-06-01

    Full Text Available Over the last ten years, the treatment of seronegative spondyloarthropathies has changed dramatically with the introduction of the anti-tumor necrosis factor alpha (TNFα agents. Nevertheless, there is a growing number of studies describing several adverse reactions in patients treated with biological agents. In the present report we describe the case of a 22-year-old male patient with ankylosing spondylitis who developed a “paradoxic” adverse reaction, while receiving infliximab.

  8. [Comorbid autoimmune pathology in patients treated with disease modifying drugs].

    Science.gov (United States)

    Goncharova, Z A; Sizyakina, L P; Belovolova, R A; Megeryan, V A

    2016-01-01

    Because of intensive growth of the prevalence of multiple sclerosis (MS) and other autoimmune diseases (AID) during the last years, the comorbidity of MS and AID is not a rarity. In this literature review, the development of comorbid AID in patients with MS is considered to be the probable complication of disease modifying therapy with drugs of different groups. The authors present the own data on the prevalence of comorbid autoimmune pathology in patients with MS treated with disease modifying drugs.

  9. Supraclavicular node disease is not an independent prognostic factor for survival of esophageal cancer patients treated with definitive chemoradiation.

    Science.gov (United States)

    Jeene, Paul M; Versteijne, Eva; van Berge Henegouwen, Mark I; Bergmann, Jacques J G H M; Geijsen, Elisabeth D; van Laarhoven, Hanneke W M; Hulshof, Maarten C C M

    2017-01-01

    The prognostic value of supraclavicular lymph node (SCN) metastases in esophageal cancer is not well established. We analyzed the prognostic value of SCN disease in patients after definitive chemoradiation (dCRT) for esophageal cancer. We retrospectively analyzed 207 patients treated between 2003 and 2013 to identify the prognostic value of metastasis in the SCN on treatment failure and survival. All patients were treated with external beam radiotherapy (50.4 Gy in 28 fractions) combined with weekly concurrent paclitaxel 50 mg/m(2) and carboplatin AUC2. Median follow-up for patients alive was 43.3 months. The median overall survival (OS) for all patients was 17.5 months. OS at one, three and five years was 67%, 36% and 21%, respectively. For patients with metastasis in a SCN, OS was 23.6 months compared to 17.1 months for patients without metastasis in the SCN (p = .51). In multivariate analyses, higher cT status, cN status and adenocarcinoma were found to be prognostically unfavorable, but a positive SCN was not (p = .67). Median OS and median disease-free survival for tumors with SCN involvement and N0/1 disease was 49.0 months and 51.6 months, respectively, compared to 14.2 months and 8.2 months, respectively, in patients with N2/3 disease. In esophageal cancer treated with dCRT, the number of affected lymph nodes is an important independent prognostic factor, whereas involvement of a SCN is not. Supraclavicular lymph nodes should be considered as regional lymph nodes and treated with curative intent if the total number of involved lymph nodes is limited.

  10. Severe hyponatraemia in an amiloride/hydrochlorothiazide-treated patient

    NARCIS (Netherlands)

    Van Assen, S.; Mudde, A.H.

    1999-01-01

    A 85-year-old woman treated with, among other drugs, a thiazide diuretic presented with a severe hyponatraemia. She met several of the criteria for SIADH and, besides drugs, no cause for SIADH was found. After stopping the thiazide diuretic and restricting fluid intake the patient recovered fully. I

  11. Constructing Data Curation Profiles

    Directory of Open Access Journals (Sweden)

    Michael Witt

    2009-12-01

    Full Text Available This paper presents a brief literature review and then introduces the methods, design, and construction of the Data Curation Profile, an instrument that can be used to provide detailed information on particular data forms that might be curated by an academic library. These data forms are presented in the context of the related sub-disciplinary research area, and they provide the flow of the research process from which these data are generated. The profiles also represent the needs for data curation from the perspective of the data producers, using their own language. As such, they support the exploration of data curation across different research domains in real and practical terms. With the sponsorship of the Institute of Museum and Library Services, investigators from Purdue University and the University of Illinois interviewed 19 faculty subjects to identify needs for discovery, access, preservation, and reuse of their research data. For each subject, a profile was constructed that includes information about his or her general research, data forms and stages, value of data, data ingest, intellectual property, organization and description of data, tools, interoperability, impact and prestige, data management, and preservation. Each profile also presents a specific dataset supplied by the subject to serve as a concrete example. The Data Curation Profiles are being published to a public wiki for questions and discussion, and a blank template will be disseminated with guidelines for others to create and share their own profiles. This study was conducted primarily from the viewpoint of librarians interacting with faculty researchers; however, it is expected that these findings will complement a wide variety of data curation research and practice outside of librarianship and the university environment.

  12. Cerebral Targeting of Acupuncture at Combined Acupoints in Treating Essential Hypertension: An Rs-fMRI Study and Curative Effect Evidence

    Directory of Open Access Journals (Sweden)

    Yanjie Wang

    2016-01-01

    Full Text Available The study attempted to explore that the synergistic effect of acupoints combination is not a simple superposition of single acupoint’s effect by comparing and analyzing the changes of blood pressure (BP, SF-36, and brain regions after acupuncture treatment. 47 patients were randomly divided into LR3+KI3 group, LR3 group, and KI3 group. Subjects received Rs-fMRI scan, BP measurement, and SF-36 questionnaires before and after treatment and short-term acupuncture treatment. After treatment, there were no significant differences in BP and SF-36 among 3 groups, compared to the case before treatment, SBP of 3 groups decreased, and DBP significantly decreased while vitality and mental health significantly increased in LR3+KI3 group. Both number and scopes of changes of brain regions in LR3+KI3 group were the largest, which mainly included BAs 3, 4, 8, 19, 21, 24, 32, 44, and 45. In conclusion, acupuncture at LR3+KI3 may auxiliarily reduce BP and improve the vitality and mental health of patients, and the changes of brain regions were related to somatesthesia, movement, vision, audition, emotion and mood, language, memory, etc. BAs 4, 9, 10, 24, 31, 32, and 46 may be the targeting brain areas of acupuncture in assisting hypotension. It is suggested that acupoints combination of LR3+KI3 maybe generates a synergistic effect, and it is not simple sum of single acupoint effect.

  13. Curative effects of microneedle fractional radiofrequency system on skin laxity in Asian patients: A prospective, double-blind, randomized, controlled face-split study.

    Science.gov (United States)

    Lu, Wenli; Wu, Pinru; Zhang, Zhen; Chen, Jinan; Chen, Xiangdong; Ewelina, Biskup

    2017-04-01

    To date, no studies compared curative effects of thermal lesions in deep and superficial dermal layers in the same patient (face-split study). To evaluate skin laxity effects of microneedle fractional radiofrequency induced thermal lesions in different dermal layers. 13 patients underwent three sessions of a randomized face-split microneedle fractional radiofrequency system (MFRS) treatment of deep dermal and superficial dermal layer. Skin laxity changes were evaluated objectively (digital images, 2 independent experts) and subjectively (patients' satisfaction numerical rating). 12 of 13 subjects completed a course of 3 treatments and a 1-year follow-up. Improvement of nasolabial folds in deep dermal approach was significantly better than that in superficial approach at three months (P=.0002) and 12 months (P=.0057) follow-up. Effects on infraorbital rhytides were only slightly better (P=.3531). MFRS is an effective method to improve skin laxity. Thermal lesion approach seems to provide better outcomes when applied to deep dermal layers. It is necessary to consider the skin thickness of different facial regions when choosing the treatment depth.

  14. Physical Activity in Patients Treated With Peritoneal Dialysis

    Science.gov (United States)

    Thangarasa, Tharshika; Imtiaz, Rameez; Hiremath, Swapnil; Zimmerman, Deborah

    2017-01-01

    Background: Patients with chronic diseases are known to benefit from exercise. Despite a lack of compelling evidence, patients with end-stage kidney disease treated with peritoneal dialysis are often discouraged from participating in exercise programs that include resistance training due to concerns about the development of hernias and leaks. The actual effects of physical activity with or without structured exercise programs for these patients remain unclear. The purpose of this study is to more completely define the risks and benefits of physical activity in the end-stage kidney disease population treated with peritoneal dialysis. Methods/design: We will conduct a systematic review examining the effects of physical activity on end-stage kidney disease patients treated with peritoneal dialysis. For the purposes of this review, exercise will be considered a purposive subcategory of physical activity. The primary objective is to determine if physical activity in this patient population is associated with improvements in mental health, physical functioning, fatigue and quality of life and if there is an increase in adverse outcomes. With the help of a skilled librarian, we will search MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials for randomized trials and observational studies. We will include adult end-stage kidney disease patients treated with peritoneal dialysis that have participated in an exercise training program or had their level of physical activity assessed directly or by self-report. The study must include an assessment of the association between physical activity and one of our primary or secondary outcomes measures. We will report study quality using the Cochrane Risk of Bias Assessment Tool for randomized controlled trials and the Newcastle–Ottawa Scale for observational studies. Quality across studies will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. The

  15. 中西医结合治疗小儿细菌性腹泻疗效观察%Combine Traditional Chinese and Western Medicine in Treating Pediatric Bacterial Diarrhea Curative Effects

    Institute of Scientific and Technical Information of China (English)

    徐馥

    2012-01-01

    目的:探讨口服头孢克肟治疗小儿细菌性腹泻的疗效.方法:在门诊选择92例小儿细菌性腹泻随机分为治疗组(52例)、对照组(40例)进行比较.结果:治疗组总有效率(96.15%)与对照组总有效率(62.5%)有显著性差异(P<0.05).结论:口服头孢克肟治疗小儿细菌性腹泻效果显著,无明显不良反应,使用安全、方便.%Objective: To study the treatment of children, oral eephalosporins latter bacterial diarrhea curative effect. Methods: 92 cases of children in outpatient service choice bacterial diarrhea divided into the treatment group ( 52 rases ) and control group ( n=40 ) are compared. Results: The total effective rate of the treatment group( 96.15% )and the control group total effective rate( 62.5% ) significant difierenc.e( P<0.05 ). Conclusion; Oral cephalosporins g in treating pediatric bacterial diarrhea latter effect significantly, no obvious adverse reaction. the use of safe, convenient.

  16. Silent venous thromboembolism in multiple myeloma patients treated with lenalidomide.

    Science.gov (United States)

    Isoda, Atsushi; Sato, Naru; Miyazawa, Yuri; Matsumoto, Yoshinobu; Koumoto, Mina; Ookawa, Masahito; Sawamura, Morio; Matsumoto, Morio

    2015-09-01

    Lenalidomide treatment in combination with dexamethasone and/or chemotherapy is associated with a significant risk of venous thromboembolism (VTE) in patients with multiple myeloma (MM). However, the incidence of asymptomatic VTE in lenalidomide-treated MM patients remains unclear. A total of 80 relapsed and refractory MM patients treated with lenalidomide-containing regimens in a single institution between July 2010 and July 2014 were retrospectively analyzed. Of these, eight patients had asymptomatic VTE before starting lenalidomide. The remaining 72 patients received thromboprophylaxis with low-dose aspirin (100 mg daily) and monitoring of plasma D-dimer levels on each visit. During the median follow-up time of 7.3 months (range 1.0-43.5 months), 29 patients (40.3 %) showed an elevation of D-dimer (≥2.5 μg/mL), and 13 (18.1 %) showed asymptomatic VTE in a lower extremity. Median time to asymptomatic VTE events from initiation of lenalidomide treatment was 3.0 months (range 1.0-13.1 months). All patients having an asymptomatic VTE continued lenalidomide treatment on warfarinization (target international normalized ratio 1.5-2.5), and none of them developed symptomatic VTE. In conclusion, an asymptomatic VTE event occurred in 18 % of Japanese MM patients receiving lenalidomide-containing therapy despite aspirin prophylaxis. Serial monitoring of plasma D-dimer levels and early intervention may help to prevent symptomatic or lethal VTE events.

  17. Curative Effect Analysis of Treating Thoracolumbar Vertebral Compression Fracture Through Injured Vertebra Nail%经伤椎置钉治疗胸腰椎压缩性骨折的疗效分析

    Institute of Scientific and Technical Information of China (English)

    时代; 顾德毅; 荆鑫

    2014-01-01

    目的:探究经伤椎椎弓根复位固定的对于治疗胸腰椎骨折的可行性及其临床疗效。方法根据随机数字表法将60例单椎体胸腰椎骨折患者分为30例的经伤椎椎弓根固定的6钉固定术(6钉组)和30例的单纯行跨伤椎的4钉固定术(4钉组),对所有的患者随访12~43个月,平均随访(27.65±2.42)个月,通过比较两组的手术时间、术中出血量、术后卧床时间、术后伤口引流量等从而得到围手术期指标及伤椎前后缘高度比值内固定失败率腰背痛评分改善指数及神经功能恢复情况。结果两组围手术期相关指标中术中出血量、手术时间、术后卧床时间比较,差异有统计学意义(P<0.05),4钉组过度撑开致术后螺钉松动率为13.33%,后凸加重发生率为10.00%,这是4钉组的情况,但是6钉组则不存在此情况。4钉组术后1周和术后6个月随访腰背痛评分平均改善率均低于6钉组,差异有统计学意义,但两组术后神经功能恢复情况具有较大的差异无统计学意义。结论经伤椎椎弓根置钉能更直接牢固骨折和固定复位,改善应力分布和固定的强度,比传统跨伤椎固定能更好的维持矫正效果。%Objective The feasibility and clinical curative effect of treating thoracolumbar vertebral fracture through resetting and fixing of injured vertebral pedicle are discussed in the thesis. Methods 60 patients with single-vertebral thoracolumbar fracture are divided into two groups according to the random number table method;the first group has 30 patients who are subjected to 6-nail fixation of injured vertebral pedicle fixation (6-nail group);the second group has 30 patients who are subjected to 4-nail fixa-tion of simple line-cross injured vertebra (4-nail group). The follow-up visit time of all patients is 12 to 43 months; the average time is (27.65±2.42) months. Perioperative indicators such as operation time, the amount of intraoperative blood loss

  18. Avascular osteonecrosis in patients treated for Hodgkin`s disease

    Energy Technology Data Exchange (ETDEWEB)

    Enrici, R.M.; Donato, V.; Santoro, M. [La Sapienza Univ. of Rome, Inst. of Radiology, Chair of Radiation Oncology, Rome (Italy); Tombolini, V. [Univ of L`Aquila, Hospital S. Maria di Collemaggio, Dept. of Radiation Oncology, L`Aquila (Italy); Anselmo, A.P. [La Sapienza Univ. of Rome, Dept. of Human Biopathology, Haematology Section, Rome (Italy)

    1998-09-01

    The aim of this study is to assess the risk of avascular osteonecrosis (AVN) of the femoral head in patients treated for Hodgkin`s disease (HD), in relation to the type of treatment they have received. For this purpose, a cohort of 1391 patients treated for HD at University of Rome between 1972 and 1996 was divided into 2 groups according to their initial treatment. The first group contained 784 patients treated, at the onset of HD, either with chemotherapy (CT) containing steroids, combined in some cases with subdiaphragmatic radiotherapy (RT), or with subdiaphragmatic RT combined with CT without steroids. The second group was made up of 607 patients who had received, initially, supradiaphragmatic RT alone or supradiaphragmatic RT combined with CT without steroids. For the purpose of this study, only the 784 patients belonging to the first group were observed for the appearance of AVN, which occurred in 9 cases. The period of time which elapsed between the end of treatment and the radiological evidence of AVN ranged from 23 to 97 months, with an average of 35 months. Because the number of cases of AVN was so small, the pathogenesis of this complication could not be identified. (au) 55 refs.

  19. Addison disease in patients treated with glucocorticoid therapy.

    LENUS (Irish Health Repository)

    Cronin, C C

    2012-02-03

    Acute adrenal crisis in patients with unrecognized chronic adrenocortical failure is difficult to diagnose and potentially fatal. We describe 2 patients with acute adrenal crisis whose diagnoses were hindered because of concomitant glucocorticoid treatment. Acute adrenal insufficiency is primarily a state of mineralocorticoid deficiency. Prednisolone and prednisone, the most frequently prescribed anti-inflammatory corticosteroid agents, have minimal mineralocorticoid activity. Several conditions that may be treated with pharmacological glucocorticoids are associated with an increased risk of Addison disease. An acute adrenal crisis, against which concurrent glucocorticoid therapy does not confer adequate protection, may develop in such patients.

  20. Hearing Loss in Patients with Shunt-Treated Hydrocephalus.

    Science.gov (United States)

    Panova, Margarita V; Geneva, Ina E; Madjarova, Kalina I; Bosheva, Miroslava N

    2015-01-01

    Hearing loss is a common manifestation of the long-term complications in patients with shunt treated hydrocephalus along with motor development disturbance, cognitive and visual impairment, epilepsy and endocrine disorders. The aim of the present study was to investigate the alterations of hearing in patients with shunt treated hydrocephalus of non-tumor etiology and at least one year after implantation of ventriculo-peritoneal shunt, as well as their impact on the quality of life of patients. The study included 70 patients (age range 1.25 years - 21.25 years) with shunted non-tumor hydrocephalus and at least one year after placement of the shunt system. Hearing alterations were proved by measuring the brainstem auditory evoked potentials (BAEP) for children up to 5 years of age and children with mental retardation; audiograms was used for children older than 5 years with normal neuro-psychological development (NPD). Of the 70 studied patients 17 (24%) had hearing loss (10 bilateral and 7-unilateral) and all of them had sensorineural hearing loss, which is associated with low weight at birth, posthemorrhagic hydrocephalus and brainstem symptoms at the time of diagnosis of hydrocephalus. Hearing pathology was found more often in shunt-treated patients with NPD retardation, poor functional status and low quality of life. Children with shunt-treated hydrocephalus have hearing loss of sensorineural type. Children with brain stem symptomatology at diagnosing hydrocephalus and children with post-hemorrhagic hydrocephalus show higher risk of hearing loss. Children with shunted hydrocephalus and hearing loss show lower NPD, lower quality of life and lower functional status.

  1. Tumor site and disease stage as predictors of quality of life in head and neck cancer: a prospective study on patients treated with surgery or combined therapy with surgery and radiotherapy or radiochemotherapy.

    Science.gov (United States)

    Veldhuis, Dennis; Probst, Gunther; Marek, Astrid; Noack, Volker; Ural, Ahmet; Adamietz, Irenaeus; Dazert, Stefan; Minovi, Amir

    2016-01-01

    In this prospective study, we compared the short-term quality of life (QOL) of two subgroups of head and neck cancers: oropharyngeal and laryngeal cancers. Patients treated with curative surgery, were asked to participate in the study using the EORTC QLQ-C30 and H&N35 questionnaires to examine QOL. The oropharynx group consisted of 32 (48 %) patients, while the larynx group consisted of 35 (52 %) patients. All patients were treated with either curative surgery alone or curative surgery combined with adjuvant radiotherapy or radiochemotherapy. The questionnaires were handed out pre- and post-therapy (10 months). At baseline, an impaired overall QOL (=EORTC QLQ-C30 global score) with a value of 53.4 for the whole patient collective was found; the overall QOL after 10 months improved (60.2, p < 0.05). Between the two patient groups, there was no difference in the global score after 10 months. The oropharynx patients described more problems with fatigue and oral cavity associated. The main symptoms in the larynx group were loss of sensual function and coughing. The present investigation revealed that the general post-therapy QOL in two subgroups of head and neck cancer reached a satisfying level.

  2. Dosimetric comparison of intensity modulated radiotherapy, volumetric-modulated arc therapy and tomotherapy in patients with gastric adenocarcinoma after curative surgery

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Objective:To compare the dosimetric differences between IMRT, VMAT and TOMO planning for gastric cancer patients.Methods: A total of 14 patients with gastric cancer after curative surgery were prospectively enrolled. In each case, IMRT, VMAT and TOMO plans were created (45Gy/25f). Dose distributions and dose–volume histograms for PTV and normal tissue were compared. A paired t test or signed-rank test was applied to compare the averages between techniques.Results:Comparison of the PTV revealed satisfactory coverage by the 95% isodose envelope in three plans. However, significantly higher conformity index (CI) and lower V20 of bone marrow were observed in TOMO plan. Moreover, IMRT and TOMO techniques both showed signiifcant reduced mean dose of the bilateral lungs compared to the VMAT. Not much difference was found in parameters of the kidney, intestine, spine, liver and heart.Conclusion:The IMRT, VMAT and TOMO plans all achieved favorable target coverage and dose sparing of the critical organs in adjuvant radiotherapy for gastric cancer. However, the TOMO technique displayed the best target dose conformity and superior sparing of the bone marrow and lungs.

  3. 乳管镜冲洗治疗乳痛症疗效观察%Curative effect observation of mastodynia treated by ductoscopy rinsing

    Institute of Scientific and Technical Information of China (English)

    宋杏丽; 李芳; 魏庆忠; 王钢

    2016-01-01

    Objective To constract and analyse the effect of taking traditional chinese drug and ductoscopy rinsing on mastodynia. Methods Retrospectively analyzed totally 225 patients with mastodynia from Oct 2012 to Oct 2013 ,which were divided into two groups,traditional chinese drug group and ductoscopy rinsing group,and comparatively observed the clinical ef-ficacy. Results The effective rate of traditional chinese drug group was 76.1%(83/109),relapse rate was 53.0%(44/83),the effective rate of ductoscopy rinsing group was 84.5%(98/116),relapse rate was 25.5%(25/98). Conclusion As a minimally invasive technique with few complication,ductoscopy is safe,effective and feasible for mastodynia,especially galactostasia would get better prognosis with ductoscopy rinsing and uneasily relapse.%目的:对比分析口服中成药和乳管镜冲洗治疗乳痛症患者的临床疗效。方法回顾性分析2012年10月~2013年10月来我院就诊的225例乳痛症患者,按不同的治疗方法分成中成药组及乳管镜冲洗治疗组,对比观察临床疗效。结果中成药组治疗有效率为76.1%(83/109),复发率为53.0%(44/83)。乳管镜冲洗组治疗有效率为84.5%(98/116),复发率为25.5%(25/98)。结论乳管镜是一项微创且并发症少的乳腺检查技术,对乳痛症患者冲洗治疗有效、安全可行,尤其是积乳症引起的乳痛,疗效确切且不易复发。

  4. Consideration of tumor size improves the accuracy of TNM predictions in patients with gastric cancer after curative gastrectomy.

    Science.gov (United States)

    Lu, Jun; Huang, Chang-ming; Zheng, Chao-hui; Li, Ping; Xie, Jian-wei; Wang, Jia-Bin; Lin, Jian-xian

    2013-09-01

    To investigate whether addition of tumor size improves the prognostic accuracy of the UICC 7th TNM staging system in gastric cancer patients who underwent radical surgery (R0 resection). The clinical and pathological data and postoperative 5-year survival rate of 507 patients with gastric cancer who underwent radical surgery (R0 resection) in our department from January 2004 to June 2006 were evaluated retrospectively. The prognostic accuracy of conventional UICC 7th TNM staging was compared with that of UICC 7th TNM staging plus tumor size. The ability of tumor size to improve the 95% confidence interval (CI) of postoperative 5-year survival rate in gastric cancer patients was assessed. Of the 507 patients, 470 (92.7%) were followed up. The five-year survival rate of these patients was 50.4%. The survival rates of patients with pT1, pT2, pT3, and pT4 stage tumors were 89.3%, 72.4%, 36.9%, and 23.7%, respectively (P TNM staging in predicting 5-year survival was 75.4% and the accuracy of tumor size plus the UICC 7th TNM staging was 77.9% (P TNM staging in predicting survival in gastric cancer patients following radical surgery (R0 resection). Tumor size is likely to be another important indicator in future UICC-TNM staging systems for gastric cancer patients. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

  5. Curative Effect of Unite Yupingfeng in Allergic Rhinitis Patients%联合玉屏风颗粒治疗变应性鼻炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨立新; 赵伍西; 周宁

    2013-01-01

    目的:研究联合玉屏风颗粒治疗变应性鼻炎(Allergic rhinitis ,AR)的疗效及对AR患者外周血白介素-4(Inter-leukin ,IL-4)和γ-干扰素(Interferon ,IFN-γ)的影响。方法:选择我院耳鼻喉科门诊2010年4月-2013年4月AR患者58例,随机分为治疗组与研究组,研究组在治疗组常规使用抗组胺药、抗白三烯药、鼻用或口服糖皮质激素治疗基础上加用玉屏风颗粒。同时选择健康体检者29例为对照组进行对照研究。治疗前及治疗后1个月、3个月、6个月测定外周血IL-4和IFN-γ的浓度,并观察临床症状及体征。结果:治疗组与研究组在治疗前及治疗期间体征评分比较无明显差异(P>0.05),IL-4和IFN-γ水平比较无明显差异(P>0.05)、治疗期间症状评分及疗效两组比较有差异(P<0.05)。停药后3个月两组在症状及体征评分、疗效、IL-4和IFN-γ的水平均有差异(P<0.05)。结论:联合玉屏风颗粒治疗AR可提高疗效,对AR患者的免疫状态有恢复作用且作用长久。%Objective :To investigate the curative effect of unite Yupingfeng in AR patients and effect on peripheral blood IL-4 and IFN-γin AR patients .Methods :58 AR patients were chosen in outpatients service of Otorhinolaryngolo-gy from April 2010 to April 2013 .58 AR patients were divided into treatment group and research group in random . Treatment group were treated with drug of antihistamine ,antileukotriene ,intranasal or oral corticosteroids ,Research group were treated with Yupingfeng particle in addition .29 Healthy controls were chosen .Peripheral blood concentra-tion of IL-4 and IFN-γwere measured before treatment and one month ,three months ,six months after treatment .Clini-cal symptoms and physical signs were observed .Results:Grade of physical signs weren’t different before treatment pe-riod and in treatment period between treatment group and research group (P>0

  6. 放散状与聚焦状冲击波治疗足底筋膜炎疗效比较%Comparison of the Curative Effect of Radial and Focused Extracorporeal Shock Waves in Treating the Plantar Fasciitis

    Institute of Scientific and Technical Information of China (English)

    张隆浩; 满立波; 黄广林; 王海; 徐啸

    2012-01-01

    Objective To compare the curative effect of radial and focused extracorporeal shock waves in the treatment of plantar fasciitis. Methods Fifty two patients with plantar fasciitis were included in the study, 26 of them received radial extracorporeal shock waves therapy (group R) and the others received focused extracorporeal shock waves therapy (group F). 5 Hz impulses of radial extracorporeal shock waves was applied for group R for 15 mm,2,000 impulses per session,and 2-3 bar air pressure. 1 Hz impulses was applied for group F for 15 mm, 1,200 impulses per session,and at the voltage of 7-8 kV. Each patient received three sessions of treatment with an interval of 1 week. Visual Analog Scale (VAS) score was used to evaluate the extent of pain before the therapy and 4 or 12 weeks after the last therapy. Results Prior to the therapy,the VAS scores were similar for both groups. VAS scores of 4 and 12 weeks after the therapy were significantly lower than before therapy (P 0.05). Conclusion Radial extracorporeal shock waves therapy showed a better effectiveness for treating plantar fasciitis in short-term, while there was no significant long-term difference in therapeutic effect between the two groups.%目的:比较放散状与聚焦状冲击波治疗足底筋膜炎的疗效.方法:52例足底筋膜炎患者被分为放散状冲击波治疗组(放散组)与聚焦状冲击波治疗组(聚焦组),每组26例.放散组患者治疗频率为5 Hz,治疗探头15 mm,治疗压力2~3bar,冲击波次数2000,手持压力中-高.聚焦组患者治疗电压7~8 kV,冲击频率60次/min,冲击次数1200次.所有患者均治疗3次,每次治疗间隔7天,治疗部位均为患侧跟骨内侧结节.治疗前和末次治疗后4周后和12周后,采用视觉模拟评级法(VAS)评估患者治疗前后疼痛强度.结果:治疗前两组患者VAS评分相近,末次治疗4周后及12周后,VAS评分均显著低于治疗前,两组之间的差异有统计学意义(P<0.05);本次治疗4

  7. Evaluation of curative effect of basic treatment of periodontitis on patients with aggressive periodontitis%侵袭性牙周炎患者牙周基础治疗的效果评价

    Institute of Scientific and Technical Information of China (English)

    汤莉

    2014-01-01

    Objective To analyze the curative effect of invasive periodontal basic treatment on periodontitis patients.Methods 40 patients(87 teeth) with aggressive periodontitis were treated with basic therapy, January,2011 to September,2014. Results After periodontal basic treatment,bleeding index, plaque index, clinical attachment loss,probing depth were significantly lower than those before periodontal basic treatment(P<0.05),the rate of tooth mobility were significantly lower than those before periodontal basic treatment(P<0.05), and significant decrease in I degrees, I I degrees. Conclusion Periodontal basic treatment on patients with aggressive periodontitis is effect, can improve the state of the periodontitis tissue, fix the loose tooth.%目的:评价侵袭性牙周炎患者采用牙周基础治疗的临床疗效。方法:选择我院2011年1月~2014年9月收治的40例(87颗牙)侵袭性牙周炎患者,采用牙周基础治疗。结果:患者治疗后,出血指数、菌斑指数、附着丧失、牙周探诊深度均低于治疗前(P<0.05)。治疗后牙齿松动比率均低于治疗前(P<0.05),达到I I度、I I I度的明显减少。结论:侵袭性牙周炎患者采用牙周基础治疗效果较好,可有效改善牙周组织状况,固定松动牙齿。

  8. Curative effect of minimally invasive sclera buckling on single retinal detachment

    Directory of Open Access Journals (Sweden)

    Yun-Huan Li

    2015-02-01

    Full Text Available AIM: To investigate the curative effect of minimally invasive sclera buckling on single retinal detachment. METHODS:Totally, 100 cases of patients with retinal detachment(106 eyesenrolled in our hospital were randomly divided into observation group and control group, 53 eyes in each group. Patients in observation group were treated with minimally invasive sclera buckling, while patients in control group received traditional limbal conjunctival incision. After surgery, patients were all followed up for 6~18mo, during which the retinal recurrence situation, degree of vision enhancement and compliance occurrence rate was recorded. RESULTS: The retinal reattachment rate once of observation group(96.22%was significantly higher than that of control group(88.68%, there was statistically significance(PPPCONCLUSION: The improved minimally invasive sclera buckling can significantly enhance the curative effect for retinal detachment, decrease the compliance occurrence rate, improve vision function, and is a scientific, practical and rigorous tool for retinal detachment treatment.

  9. Gallium-67 scintigraphy in patients with hemochromatosis treated by deferoxamine

    Energy Technology Data Exchange (ETDEWEB)

    Nagamachi, Shigeki; Hoshi, Hiroaki; Jinnouchi, Seishi; Ono, Seiji; Watanabe, Katsushi

    1988-05-01

    Gallium scintigraphy was performed as an aid for determining the presence or absence of malignant neoplasm in two patients with hemochromatosis treated by deferoxamine. However, gallium scan images could not be obtained. So gallium scintigraphy was performed once more to investigate the cause of low activity. Both patients had heavy urinary excretion of gallium in the first 24 hrs after the injection, and activity was very low on the day of examination. This phenomenon may be attributed to the effect of deferoxamine which is highly bound to the gallium.

  10. [Tranexamic acid gel in patients treated with oral anticoagulants].

    Science.gov (United States)

    Ripollés-de Ramón, Jorge; Muñoz-Corcuera, Marta; Bravo-Llatas, Carmen; Bascones-Martínez, Antonio

    2014-12-09

    Patients treated with oral anticoagulants have increased susceptibility to bleeding, and therefore any surgical medical procedure and especially oral surgery requires a therapeutic approach that minimizes bleeding effects in these patients. The working hypothesis was based on studies of local application of tranexamic acid after maxillofacial interventions as effective therapeutic alternative for the prevention and control of bleeding. The aim was to assess the effectiveness of the application of a gel solution tranexamic acid after tooth extraction in anticoagulated patients in terms of healing time and degree of healing. The results indicate that application of tranexamic acid gel is very effective for consistency and maintenance in the place of action and shows its efficacy as a procoagulant material. The application of a gel solution of tranexamic acid in oral anticoagulants patients ameliorates healing time and the bleeding time within the first 48-72 h. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

  11. Antierythropoietin Antibodies in Hemodialysis Patients Treated with Recombinant Erythropoietin

    Directory of Open Access Journals (Sweden)

    Savaş ÖZTÜRK

    2014-05-01

    Full Text Available OBJECTIVE: Erythropoietin resistance is a serious problem in patients treated with recombinant erythropoietin. Antierythropoietin antibodies are considered to be one of the causes of this resistance. MATERIAL and ME THODS: We investigated antierythropoietin antibodies in chronic hemodialysis patients and compared the results with healthy controls by means of establishing an ELISA method. A total of 121 chronic hemodialysis patients receiving recombinant erythropoietin were included in the study. The patients were subdivided according to the type of recombinant erythropoietin (erythropoietin-α or erythropoietin-β they had been treated with in the last six months. RESULTS: The absorbance values of patients were compared with the absorbance values of the control group by a specific and reproducible method. LOD (limit of detection and LOQ (limit of quantitation values were also calculated. The difference in the absorbance values between the therapy and control groups was statistically significant. CONCLUSION: Both erythropoietin-α and erythropoietin-β induce production of antibodies against erythropoietin. Anti rh-EPO antibodies may play a role in EPO resistance.

  12. Incidence and Management of Rash in Telaprevir-Treated Patients.

    Science.gov (United States)

    Smith, Michael A; Johnson, Heather J; Chopra, Kapil B; Dunn, Michael A; Ulrich, Ashley M; Mohammad, Rima A

    2014-09-01

    Telaprevir-induced rash is a common, therapy-limiting adverse drug event (ADE) for patients with hepatitis c virus (HCV) infection. Given the similarity between telaprevir and simeprevir, real-world management of rash during treatment with an NS3/4A protease inhibitor and its implications are important. The objectives of this study were to determine the incidence of rash in telaprevir-treated patients, its management, and the impact on sustained virological response and to identify any risk factors for rash development. This was a retrospective study of adult patients who were treated with telaprevir in a hepatology clinic from July 1, 2011, to August 31, 2012. Pertinent information on demographics, past medical history, medications, laboratory data, outcomes of rash, other ADEs related to treatment, and physician grading of rash were collected. Of 159 patients included, 44% (70/159) developed rash, and 4% (7/159) discontinued therapy because of rash. Median number of days until rash did not differ between patients who continued and discontinued therapy (25 vs 45, respectively; P = 0.88). Patients who developed rash were more likely to have lower actual body weight (ABW) or body mass index (BMI; P ≤ 0.01). No significant difference in rash development when drug-allergy history was considered was found. Most patients who continued telaprevir were prescribed topical corticosteroids (93.7%) and cetirizine (41.3%). Patients who discontinued therapy were more likely to be evaluated by dermatology (P = 0.002), prescribed oral corticosteroids (P = 0.02), hydroxyzine (P = 0.001), and topical triamcinolone (P = 0.01). ABW and BMI appear to be related to rash development. This finding may have implications in the treatment of HCV with simeprevir, given its similarity to telaprevir. © The Author(s) 2014.

  13. The DCC Curation Lifecycle Model

    Directory of Open Access Journals (Sweden)

    Sarah Higgins

    2008-08-01

    Full Text Available Lifecycle management of digital materials is necessary to ensure their continuity. The DCC Curation Lifecycle Model has been developed as a generic, curation-specific, tool which can be used, in conjunction with relevant standards, to plan curation and preservation activities to different levels of granularity. The DCC will use the model: as a training tool for data creators, data curators and data users; to organise and plan their resources; and to help organisations identify risks to their digital assets and plan management strategies for their successful curation.

  14. Effect of Risperidone Combined with Sertraline on Curative Effect of Patients with Obsessive-Compulsive Disorder%利培酮合并舍曲林对强迫症患者疗效的影响

    Institute of Scientific and Technical Information of China (English)

    段海水; 吕贝

    2016-01-01

    ABSTRACT:Objective To observe the effect of risperidone combined with sertraline on the obsessive-compulsive disorder patients. Methods 80 cases of obsessive-compulsive disorder in our hospital were selected as the observation objects, the patients were divided into the observation group and the control group according to the random grouping method, 40 cases in each group, the control group were treated with sertraline treatment alone, patients in the observation group were treated with risperidone on the basis of the contral group. The Yale Brown Obsessive Compulsive Scale (Y-BOCS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) were used to evaluate the curative effect. Results After treatment, the indexes of the two groups were signiifcantly decreased, and the observation group was signiifcantly higher than the control group, the difference between the groups was signiifcant (P<0.05). Conclusion Patients with obsessive-compulsive disorder accepting sertraline combined with risperidone treatment can receive signiifcant effect, can improve the symptoms of patients, high safety, it is worth to be popularized in clinical application.%目的:观察利培酮合并舍曲林对强迫症患者的影响。方法选取本院收治的80例强迫症患者作为观察对象,并按照随机分组法将患者分为观察组和对照组,每组40例,对照组患者给予单纯的舍曲林治疗,观察组患者在对照组治疗的基础上联合应用利培酮。采用耶鲁-布郎强迫量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评定疗效。结果经过治疗后两组患者的以上指标均有明显的下降,且观察组的下降幅度显著大于对照组,组间差异具有显著性(P均<0.05)。结论对于强迫症患者在舍曲林的基础上联合应用利培酮治疗能够收到显著的效果,有助于改善患者的症状,安全性高,值得在临床中进行推广应用。

  15. Observation of curative effect of Xiyanping on treating capillarity bronchitis%喜炎平治疗毛细支气管炎60例疗效观察

    Institute of Scientific and Technical Information of China (English)

    马洪英; 唐毅

    2011-01-01

    目的 现察喜炎平对毛细支气管炎的治疗效果.方法 将120例毛细支气管炎患者随机分为治疗组与对照组,每组均为60例,两组患者在吸氧、祛痰的基础上,治疗组用喜炎平治疗,对照组用病毒唑治疗,根据治疗效果进行对比分析.结果 治疗组在发热、喘憋、肺部罗音消失时间缩短等方面优于对照组,差异有显著性(P<0.05).结论 喜炎平抗病毒作用比病毒唑强,治疗毛细支气管炎取得满意疗效,值得临床推广.%Objective To observe Xiyanping's curative effect on capillarity bronchitis. Methods 120 cases with capillarity bronchitis were stochastically divided into two groups, including the treatment group ( 60 cases) and the control group (60 cases). Based on oxygen- breathing and phlegm dispelling, the treatment group was treated with Xiyanping, while the control group with ribavirin. Results The result indicates that the vanishing time for Xiyanping group's fever, suppression of heavy breath and lungs Rales were reduced. Conclusion Xiyanping's anti-virus function is stronger than ribavirin.

  16. Screen Practice in Curating

    DEFF Research Database (Denmark)

    Toft, Tanya Søndergaard

    2014-01-01

    During the past one and a half decade, a curatorial orientation towards "screen practice" has expanded the moving image and digital art into the public domain, exploring alternative artistic uses of the screen. The emergence of urban LED screens in the late 1990s provided a new venue that allowed...... for digital art to expand into public space. It also offered a political point of departure, inviting for confrontation with the Spectacle and with the politics and ideology of the screen as a mass communication medium that instrumentalized spectator positions. In this article I propose that screen practice...... to the dispositif of screen practice in curating, resulting in a medium-based curatorial discourse. With reference to the nomadic exhibition project Nordic Outbreak that I co-curated with Nina Colosi in 2013 and 2014, I suggest that the topos of the defined visual display area, frequently still known as "the screen...

  17. Curating Gothic Nightmares

    Directory of Open Access Journals (Sweden)

    Heather Tilley

    2007-10-01

    Full Text Available This review takes the occasion of a workshop given by Martin Myrone, curator of Gothic Nightmares: Fuseli, Blake, and the Romantic Imagination (Tate Britain, 2006 as a starting point to reflect on the practice of curating, and its relation to questions of the verbal and the visual in contemporary art historical practice. The exhibition prompted an engagement with questions of the genre of Gothic, through a dramatic display of the differences between ‘the Gothic' in literature and ‘the Gothic' in the visual arts within eighteenth- and early nineteenth-century culture. I also address the various ways in which 'the Gothic' was interpreted and reinscribed by visitors, especially those who dressed up for the exhibition. Finally, I consider some of the show's ‘marginalia' (specifically the catalogue, exploring the ways in which these extra events and texts shaped, and continue to shape, the cultural effect of the exhibition.

  18. Digital Curation and Doctoral Research

    Directory of Open Access Journals (Sweden)

    Daisy Abbott

    2015-02-01

    Full Text Available This article considers digital curation in doctoral study and the role of the doctoral supervisor and institution in facilitating students’ acquisition of digital curation skills, including some of the potentially problematic expectations of the supervisory relationship with regards to digital curation. Research took the form of an analysis of the current digital curation training landscape, focussing on doctoral study and supervision. This was followed by a survey (n=116 investigating attitudes towards importance, expertise, and responsibilities regarding digital curation. This research confirms that digital curation is considered to be very important within doctoral study but that doctoral supervisors and particularly students consider themselves to be largely unskilled at curation tasks. It provides a detailed picture of curation activity within doctoral study and identifies the areas of most concern. A detailed analysis demonstrates that most of the responsibility for curation is thought to lie with students and that institutions are perceived to have very low responsibility and that individuals tend to over-assign responsibility to themselves. Finally, the research identifies which types of support system for curation are most used and makes suggestions for ways in which students, supervisors, institutions, and others can effectively and efficiently address problematic areas and improve digital curation within doctoral study.

  19. Erectile dysfunction in patients with chronic pain treated with opioids.

    Science.gov (United States)

    Ajo, Raquel; Segura, Ana; Inda, María-Del-Mar; Margarit, César; Ballester, Pura; Martínez, Emi; Ferrández, Guillermina; Sánchez-Barbie, Ángel; Peiró, Ana M

    2017-07-21

    Chronic pain is associated with comorbidities that have an impact on the quality of life of patients and, among others, affect their sexual functioning. One of the most relevant side effects of opioid analgesics is erectile dysfunction (ED), due in part to the inhibition of the gonadal-pituitary-hypothalamic axis and the decline in testosterone levels. To evaluate ED and effectiveness of treatment in men with chronic pain treated with long-term opioids. Prospective observational study lasting 3 years, where the intensity of pain (visual analogue scale, 0-10cm), erectile function (IIEF-EF, range 1-30 points), quality of life (EQ-VAS, 0-100mm), quality of sexual life (MSLQ-QOL, 0-100 points), anxiety/depression (HAD, 0-21 points) and testosterone levels, was assessed in patients who reported sexual dysfunction (ED or libido modification). A 6-month follow-up was applied to each patient after administering the usual treatment in the Andrology Unit. The study was approved by the Clinical Research Ethics Committee and data were statistically analyzed with the GraphPad Prism 5 software. ED was observed in 27.6% of patients (n=105, 57±12.2 years, mean dose of morphine equivalent=107.1±107.9mg/day, 84.3% adjuvant analgesics). After 6 months, 42% of patients showed a significant improvement after being treated with iPDE5 (48.5%) and/or testosterone gel (81.8%), with a resolution rate of 31% (p=0.000). A positive correlation was observed between the improvement of IIEF and quality of sexual life (55.5±25.7 points, p=0.000), as well as anxiety (7.4±4.3 points, p=0.048). No significant changes were observed in the levels of testosterone, in the levels of pain nor in the quality of life, which remained moderate. Erectile function and quality of sexual life, as well as anxiety, improved in patients treated chronically with opioids after administering andrological treatment. The management of patients with pain should include a review of their sexual health history given the

  20. 茎乳孔注射地西泮配合SGB治疗面肌痉挛的疗效观察%Stylomastoid Foramen Injection Diazepam with SGB Treat Hemifacial Spasm Curative Effect Observation

    Institute of Scientific and Technical Information of China (English)

    董志科

    2013-01-01

    Objective: To explore the stylomastoid foramen injection of diazepam with curative ef ect, SGB for the treatment of hemifacial spasm. Method: in 2008 May ~2009 May admit ed to our hospital 20 cases of patients with hemifacial spasm made retrospective analysis, analysis of the stylomastoid foramen injection of diazepam combined with the ef ect of SGB treatment. Results:after 1 times of injection termination of seizures in 8 cases, after 2 times of injection after termination of seizures in 6 cases, with 3~5 injections after termination of seizures in 6 cases, the patients were followed up for 1 years without recurrence. Conclusion: the stylomastoid foramen injection of diazepam with the efficacy of stel ate ganglion block in treatment of hemifacial spasm with.%目的:分析探讨茎乳孔注射地西泮配合SGB治疗面肌痉挛的疗效。方法对2008年5月~2009年5月收治于我院的20例面肌痉挛患者做出了回顾性分析,分析茎乳孔注射地西泮配合SGB治疗的疗效。结果经1次注射终止发作8例,经2次注射后终止发作6例,经3~5次注射后终止发作6例,其病例随访1年仍无复发。结论茎乳孔注射地西泮配合星状神经节阻滞治疗面肌痉挛疗效满意。

  1. Curative effect analysis of small incision surgery in the treatment of senile cataract patients%高龄白内障患者小切口手术疗效分析

    Institute of Scientific and Technical Information of China (English)

    杨学真; 郭登山

    2014-01-01

    Objective To study curative effect of small incision on patients with senile cataract surgical. Methods Selected 101 cases(123 eyes) of senile cataract patients as the research object, aged 76~92 years old. 123 eyes were randomly divided into research group (55 eyes) and phaco group (68 eyes), treated by small incision surgery and ultrasonic emulsification treatment respectively. Results Postoperative visual acuity was no significant difference between two groups(P>0.05). 53 eyes and 67 eyes occurred corneal edema respectively. the number of class I, class II and level III corneal edema had no statistical significances (χ2=0.81, P>0.81);but the team level III ratio was less than phaco group. Team corneal edema postoperative fading fast in phaco group, the number of postoperative 1 day fade eyes of study group were more than phaco group (χ2=6.45, P0.05)。两组分别有53眼和67眼出现角膜水肿。研究组和超乳组之间发生I级、II级及III级角膜水肿的眼数差异无统计学意义(χ2=0.60, P>0.05);但研究组发生III级的比例少于超乳组。研究组患者角膜水肿术后消退时间快于超乳组,其中术后1 d消退的眼数研究组多于超乳组(χ2=4.01, P<0.05)。结论小切口手术治疗高龄白内障,是一种比较安全、有效的方式。

  2. Curative effect of continuous positive airway pressure on treatment of patients with obstructive sleep apnea hypopnea syndrome and hypertension: A Meta-analysis

    Directory of Open Access Journals (Sweden)

    Bi-fang MIAO

    2016-12-01

    Full Text Available Objective  To systematically evaluate the curative effect of continuous positive airway pressure (CPAP on treatment of patients with obstructive sleep apnea hypopnea syndrome (OSAHS and hypertension. Methods  The data were retrieved of randomized controlled trials (RCTs about the curative effect of CPAP on treatment of patients with OSAHS and hypertension from PubMed, Cochrane Library, CNKI, VIP, CBM and WanFang database from inception to Oct. 2015. Literature screening, data extraction and risk bias assessment were performed by two independent reviewers, and meta-analysis was then carried out by using RevMan 5.3 software. Results  A total of 16 RCTs involving 2101 patients were included. Meta-analysis revealed that, compared with the antihypertensive drug therapy alone, CPAP plus antihypertensive drug therapy significantly reduced the daytime systolic pressure [MD=–12.60, 95%CI(–17.68 to –7.52, P<0.00001], nighttime systolic pressure [MD=–21.90, 95%CI(–25.94 to –17.86, P<0.00001] and nighttime diastolic pressure [MD=–11.90, 95%CI(–15.44 to –8.36, P<0.00001], while created no significant difference in daytime diastolic pressure, 24-h mean systolic pressure and 24-h mean diastolic pressure in a following-up less than 12 weeks. Whereas in the following-up no less than 12 weeks, compared with the antihypertensive drug therapy alone, CPAP plus antihypertensive drug therapy significantly reduced the 24-h mean systolic pressure [MD=–7.88, 95%CI(–12.09 to –3.66, P=0.00002], 24-h mean diastolic pressure [MD=–5.14, 95%CI(–6.00 to –4.28, P<0.00001], daytime systolic pressure [MD=–5.89, 95%CI(–8.79 to –2.98, P<0.0001], daytime diastolic pressure [MD=–4.34, 95%CI(–6.32 to –2.36, P<0.0001]; nighttime systolic pressure [MD=–7.06, 95%CI(–11.12 to –2.99, P=0.0007] and nighttime diastolic pressure [MD=–4.49, 95%CI (–7.39 to –1.58, P=0.006]. Conclusions  The current evidences suggest that on the basis

  3. Winter disease summer treat acupoint sticking 68 cases of the treatment of chronic bronchitis curative effect observation and nursing care%冬病夏治穴位贴敷治疗慢性支气管炎68例疗效观察与护理

    Institute of Scientific and Technical Information of China (English)

    葛双阳; 丁小清

    2015-01-01

    Objective Winter disease summer treat acupoints were applied on the curative effect of chronic bronchitis.Methods The dog days of 68 cases of chronic bronchitis patients with acupoint sticking therapy. Results Clinical control 15 cases, 29 cases had marked effect, improvement in 19 cases, 5 cases were invalid, the total effective rate was 92.6%.Conclusions Winter disease summer acupoint sticking therapy cure chronic bronchitis has good effect, conform to the Chinese medicine Jane, and cheap, the characteristics of the test, can be used as an application of TCM appropriate technologies in community health posts.%目的:观察冬病夏治穴位贴敷对慢性支气管炎的疗效。方法:三伏天对68例慢性支气管炎患者进行穴位贴敷治疗。结果:临床控制15例,显效29例,好转19例,无效5例,总有效率92.6%。结论:冬病夏治穴位贴敷治疗慢性支气管炎有较好效果,符合中医简、便、廉、验的特点,可作为中医适宜技术在社区卫生站推广应用。

  4. [Clinical Trials for Observing the Influence of Acupuncture Needle-stimulation Induced Sharp Pain on Curative Effect in Primary Dysmenorrhea Patients].

    Science.gov (United States)

    Ru, Shang-qing; Zhang, Peng; Li, Jing; Wang, Pei; Lin, Chi; Hu, Ni-juan; Hao, Jie; Hao, Mian-yi; Sun, Jon-jun; Wang, Ya-feng; Zhu, Jiang

    2016-04-01

    To observe the influence of acupuncture needle stimulation-induced sharp pain on the curative effect of acupuncture therapy for primary dysmenorrhea (PD) patients with cold damp stagnation syndrome (CDSS). A total of 87 PD patients with CDSS experiencing abdominal pain (> or =40 mm in visual analogue scale, VAS) were randomly asigned to deqi-expectation group and no-deqi-expectation group which were further divided into deqi-expectation + sharp pain (n = 31), deqi-expectation + no-sharp pain (n = 12), no-deqi-expectation + sharp pain (n = 17), no-deqi-expectation + no- sharp pain (n =27) groups. On the first day of abdominal pain attack, bilateral Sanyinjiao (SP 6) were punctured respectively with thicker needles with deeper insertion for deqi-expectation patients and thin filiform needles with shallow insertion for no-deqi-expectation patients. The needles were manipulated for 30 s with uniform reinforcing-reducing method for all the deqi-expectation patients, which was repeated once again every 10 min during 30 min of needle retention. The VAS was used to evaluate the patients' abdominal pain severity before treatment and 0, 10 min after acupuncture needle withdrawal. Following acupuncture stimulation of SP 6, the VAS scores of menstrual pain at both 0 min and 10 min after withdrawing acupuncture needles were significantly decreased in the deqi-expectation + sharp pain group, deqi-expectation + no-sharp pain group, no-deqi-expectation+sharp pain group and no-deqi-expectation + no-sharp pain group (Pdeqi-expectation + sharp pain group ( Pdeqi-expectation plus sharp pain and deqi- expectation + no-sharp pain groups, and between no-deqi-expectation + sharp pain and no-deqi-expectation + no-sharp pain groups (P>0.05). Acupuncture stimulation of SP 6 has an immediate analgesic effect in PD women with cold damp stagnation syndrome, which was not affected by needling-induced sharp pain, deqi-expectation, and thicker or thinner needle with shallow and deeper insertion.

  5. Mortality in patients treated for hyperthyroidism with iodine-131

    Energy Technology Data Exchange (ETDEWEB)

    Hall, P.; Lundell, G.; Holm, L.E. (Karolinska Hospital, Stockholm (Sweden))

    1993-03-01

    Causes of death were studied in 10552 Swedish hyperthyroid patients treated with [sup 131]I diagnosed between 1950 and 1975. The patients were followed for an average of 15 years and were matched with the Swedish cause of death register. A total of 5400 deaths were observed and the overall standardized mortality ratio was 1.47. The standardized mortality ratio for females was 1.50 compared to 1.31 in males. The most common cause of death was from cardiovascular diseases. Significantly elevated risks were also seen for tumours, diseases of the endocrine system, respiratory system, gastro-intenstinal system, and congenital malformations. In all causes of death, except tumours and trauma, decreasing standardized mortality ratios over time were seen. Patients followed for more than 10 years had significantly elevated risks for tumours, diseases of the endocrine, respiratory, and cardiovascular systems. Patients given higher [sup 131]I activity and younger patients had higher standardized mortality ratios than those given lower activity and older patients. The hyperthyroidism per se, rather than the [sup 131]I treatment, appeared to be the major explanation for the elevated mortality. 20 refs., 3 tabs.

  6. Peripartum cardiomyopathy in a patient treated for acute myeloid leukemia

    Directory of Open Access Journals (Sweden)

    Čolović Nataša

    2016-01-01

    Full Text Available Introduction. Peripartum cardiomyopathy usually presents with systolic heart failure during the last months of pregnancy and up to five months postpartum. The disease is rare and can be fatal. Case Outline. We report a 30-year-old female who was diagnosed with acute myeloid leukemia, with maturation and cytogenetic finding of t(8;21(q22;q22,del(9(q22 in January 2004. She was treated with chemotherapy and achieved complete remission that lasts to date. She became pregnant and delivered a healthy newborn with caesarean section in 2009. Seven months later, she again became pregnant and delivered the second child with caesarean section in January 2011. Seven days after delivery she developed symptoms and signs of heart failure. Electrocardiogram showed sinus rhythm, low voltage and negative T-waves in inferior and lateral leads. Echocardiography revealed global left ventricular dysfunction with ejection fraction of 15%, with mobile thrombotic mass of 12 mm attached to the left ventricle wall. She was treated with both unfractionated and low-molecular heparin, diuretics, cardiotonics, and beta-blockers. Within six following weeks left ventricle systolic function improved up to 25-30%. The full clinical recovery was achieved in September 2013, resulting in absence of heart failure and left ventricular ejection fraction of 54%. Conclusion. Peripartum cardiomyopathy is a rare condition. The cause of cardiomyopathy is unknown, but it is believed that it could be triggered by various conditions and risk factors. Although the patient was treated with cardiotoxic drugs (doxorubicin and mitoxantrone in permitted doses, they could have been contributory factors of myocardial damage. Close monitoring of cardiac function in the peripartal period might be beneficial in patients treated with cardiotoxic drugs. [Projekat Ministarstva nauke Republike Srbije, br. 175080 I br. OI 175034

  7. [Acid-base status in patients treated with peritoneal dialysis].

    Science.gov (United States)

    Katalinić, Lea; Blaslov, Kristina; Pasini, Eva; Kes, Petar; Bašić-Jukić, Nikolina

    2014-04-01

    When compared to hemodialysis, peritoneal dialysis is very simple yet low cost method of renal replacement therapy. Series of studies have shown its superiority in preserving residual renal function, postponing uremic complications, maintaining the acid-base balance and achieving better post-transplant outcome in patients treated with this method. Despite obvious advantages, its role in the treatment of chronic kidney disease is still not as important as it should be. Metabolic acidosis is an inevitable complication associated with progressive loss of kidney function. Its impact on mineral and muscle metabolism, residual renal function, allograft function and anemia is very complex but can be successfully managed. The aim of our study was to evaluate the efficiency in preserving the acid-base balance in patients undergoing peritoneal dialysis at Zagreb University Hospital Center. Twenty-eight patients were enrolled in the study. The mean time spent on the treatment was 32.39 ± 43.43 months. Only lactate-buffered peritoneal dialysis fluids were used in the treatment. Acid-base balance was completely maintained in 73.07% of patients; 11.54% of patients were found in the state of mild metabolic acidosis, and the same percentage of patients were in the state of mild metabolic alkalosis. In one patient, mixed alkalosis with respiratory and metabolic component was present. The results of this study showed that acid-base balance could be maintained successfully in patients undergoing peritoneal dialysis, even only with lactate-buffered solutions included in the treatment, although they were continuously proclaimed as inferior in comparison with bicarbonate-buffered ones. In well educated and informed patients who carefully use this method, accompanied by the attentive and thorough care of their physicians, this method can provide quality continuous replacement of lost renal function as well as better quality of life.

  8. 腹腔镜下宫颈癌根治术与传统经腹宫颈癌根治术的临床疗效对照%Comparison of therapeutic effect of the ventral cervical cancer treated with traditional laparoscopic cervical cancer radical curative effect of cervical dis -ease

    Institute of Scientific and Technical Information of China (English)

    肖红

    2013-01-01

    目的:观察腹腔镜下宫颈癌根治术与传统经腹宫颈癌根治术对宫颈癌疾病治疗的临床疗效。方法对我院收治的90例宫颈癌(Ia-IIa期)患者随机分为治疗组和对照组,各45例,对比两组患者治疗效果。结果两组患者清扫淋巴结数目比较无统计学意义( P>0.05);对比两组患者术中出血量、肛门排气时间、下床活动时间、切口感染发生率及平均住院时间,有统计学意义(P<0.05)。结论腹腔镜下宫颈癌根治术治疗宫颈癌疾病较传统手术方式优越。%Objective To observe the ventral cervical cancer treated with traditional laparoscopic cervical cancer radical curative effect of cervical disease .Methods our hospital 90 cases of cervical cancer patients were divided into treatment group and control group ,45 cases ,com-pared two groups of patients with therapeutic effect .Results Two groups of patients with cleaning the lymph node number is no statistical signifi-cance (P>0.05);Compared to two groups of patients with intraoperative blood loss ,anal exhaust time ,ambulation time ,incision infection rate and the average length of hospital stay ,was statistically significant (P<0.05) .Conclusion Laparoscopic treatment of cervical cancer radical cervi-cal cancer disease effect is remarkable .

  9. 辨证取穴配合刺络拔罐治疗带状疱疹疗效观察%Observation of curative effect of herpes zoster treated with acupuncture based on syndrome differentiation combined with pricking and cupping

    Institute of Scientific and Technical Information of China (English)

    潘华

    2011-01-01

    目的:比较辨证取穴配合刺络拔罐法与单纯刺络拔罐法治疗带状疱疹的疗效差异.方法:将86例患者随机分为观察组(43例)、对照组(43例).观察组采用辨证取穴配合局部刺络拔罐治疗,分为肝胆湿热型、脾虚湿蕴型、气虚血瘀型,穴取曲池、足三里、三阴交等;对照组采用单纯局部刺络拔罐法.两组每日1次,7天为一疗程,2个疗程后统计疗效,1月后随访.结果:观察组愈显率为93.0%(40/43),优于对照组的67.4%(29/43)(P<0.01).后遗神经痛:观察组发生率2.3%(1/43),对照组14.0%(6/43),观察组低于对照组(P<0.05).分型比较:肝胆湿热型愈显率:观察组94.7%(18/19),对照组85.7%(18/21),差异无统计学意义(P>0.05);脾虚湿蕴型愈显率:观察组93.8%(15/16),优于对照组60.0%(9/15)(P<0.05);气虚血瘀型愈显率:观察组87.5%(7/8),明显优于对照组的28.6%(2/7)(P<0.05).结论:辨证取穴配合刺络拔罐治疗带状疱疹,针对性强、疗效明显,可显著减少后遗神经痛,疗效优于单纯刺络拔罐法.%Objective To compare the differences of curative effects of herpes zoster treated with acupuncture based on syndrome differentiation combined with pricking and cupping and simple pricking and cupping. Methods Eighty-six cases were randomly divided into an observation group (43 cases) and a control group (43 cases). In observation group, acupoints selection based on syndrome differentiation I.e. Quchi( LI 11), ZusanlKST 36), Sanyinjiao ( SP 6), etc. Were selected and pricking and cupping at affected parts were applied, and the cases were classified into damp heat in liver and gallbladder, damp retention and spleen deficiency, and qi deficiency and blood stasis. In control group, all the cases were simplely treated with pricking and cupping at affected parts. The treatment was given once a day, and seven days were made one session. The curative effect was evaluated after 2 courses, and the

  10. Thyroglobulin value in patients surgically treated for differentiated thyroid carcinoma

    Directory of Open Access Journals (Sweden)

    Mikač Gostimir

    2016-01-01

    Full Text Available Introduction. Thyroglobulin is composed glycoprotein, and it is synthesized by follicular cells of the thyroid gland. Treatment of differentiated thyroid carcinomas involves total thyroidectomy followed by radioiodine ablation of a potential remaining tissue. The measurement of thyroglobulin in the postoperative follow-up can serve as an indicator of tumor growth or recurrence of the disease. Objective. The aim of this paper is to examine the value of thyroglobulin in patients surgically treated for differentiated thyroid cancer who had metastases in the lymph nodes of the neck, as well as in operated on patients without any evident metastasis. Methods. Thyroglobulin values in the serum of 58 patients were analyzed. Two groups were formed. The thyroglobulin value was established with the use of IRMA-hTg (125I system. Normal levels of thyroglobulin were from 2 ng/ml to 65 ng/ml. For all of 58 patients, thyroglobulin was determined three times. The first, so-called pre-ablation thyroglobulin was determined immediately before the application of 131I ablation dose. The second and the third measurements were conducted six to eight months and one year, respectively, after the application of the ablation dose respectively. Results. The first group consisted of 14 patients with histologically proven metastases in the lymph nodes of the neck, while the second group consisted of 44 patients without any evident metastases. The average thyroglobulin value of pre-ablation in the patients from the first group was 43.45 ng/ml, while in the second was 7.57 ng/ml. Levene’s test (with p = 0.00, i.e p < 0.05, demonstrated a statistically significant difference. Furthermore, in both groups, there was statistically significant difference between pre-ablation and post-ablation thyroglobulin values (Student’s t-test with p < 0.05. Conclusion It can be concluded that the average value of thyroglobulin was significantly higher in patients with lymph node metastases

  11. Atropinic (Anticholinergic) Burden in Antipsychotic-Treated Patients.

    Science.gov (United States)

    Montastruc, François; Benevent, Justine; Touafchia, Anthony; Chebane, Leila; Araujo, Mélanie; Guitton-Bondon, Emmanuelle; Durrieu, Geneviève; Arbus, Christophe; Schmitt, Laurent; Begaud, Bernard; Montastruc, Jean-Louis

    2017-09-09

    Antipsychotic drugs possess side atropinic (anticholinergic) properties that may induce several adverse drug reactions (ADRs), such as memory loss or cognitive impairment. The aim of the present study was investigating anticholinergic burden in patients treated with antipsychotic drugs. All ADR reports including at least one antipsychotic and registered between 2000 and 2015 in the Midi-Pyrénées PharmacoVigilance Database were extracted and analyzed using the Anticholinergic Duran's list. The primary objective of this cross-sectional study was to calculate anticholinergic burden in antipsychotic-treated patients; the secondary one was to investigate associated factors. Among the 1,948 reports, the average number of atropinic drugs per report was 2.4 ± 1.4. At least one atropinic drug was found in 59.4% of reports (1,158), in addition to antipsychotic drugs. The mean anticholinergic burden per report was 3.9 ± 2.9. A value ≥ 3 was found in 61.7% of the reports. A significant association between anticholinergic burden, age and male gender of patients was found. The mean value of anticholinergic burden remained stable during the study period. This study showed high values of anticholinergic burden in patients receiving antipsychotics. Thus, considering the potential noxious clinical impact of atropinic properties on cognitive functions, an appropriate approach should be to reduce prescription of antipsychotics with a high anticholinergic burden but also coprescription of other frequently associated atropinic drugs, like antiparkinsonians, H1 antihistamines or imipraminic antidepressants in these patients. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. Evaluation of diagnosis and curative criterion forconcussion patients by color three- dimensionaltrascrani doppler%经颅三维多普勒技术对脑震诊断、疗效及愈后的评估

    Institute of Scientific and Technical Information of China (English)

    肖兴义; 薛贯生; 李春玲; 郭新红; 宋燕

    2001-01-01

    Objective In order to offer a noninvasive and objective examination method for assessing the clinical diagnosis and eurative criterion of concussion patients, the patients color three - dimensional transcranial doppler( 3D - TCD) characteristic at deferent phases, parameter and clincal manifestation were studied Method Parameter of Median Cerebral Artery(MCA), Base Artery(BA), the average peak forwand velocity of cerebral blood flow, train figure were tested by 3D - TCD within 24 hours, 3 - 6 days and at the end of treatment, respectively. The results were compared with clinical diagnoses and curative criterion. Result Among 135 patients who had clinically diagnosed concussion, agreeable diagnoses 101 cases, basically agreeable diagnooses 12 cases, disagreeable diagnosis 22 cases(16. 2%) .At the end of treatment, according to clinical determination 96 cases(71.1%) were cured, 39 cases(28.9%) were improved. Wave train character, figure and diagnoses prameter of cerebral spasm caused by concussion were suggested Conclusion To be one of the diagnostic bases and curative criterion, 3D- TC D technology is performable. Meanwhile, it is a new testing objective technique for assessing curative and determining prognosis.

  13. Prolonged nerve blockade in a patient treated with lithium

    Directory of Open Access Journals (Sweden)

    Lehavi A

    2012-04-01

    Full Text Available Amit Lehavi, Boris Shenderey, Yeshayahu (Shai KatzDepartment of Anesthesiology, Rambam Health Care Campus, Haifa, IsraelAbstract: We report a case of a patient, chronically treated with oral lithium, who presented with an extremely prolonged (42-hour duration of sensory and motor paralysis following an uneventful infraclavicular block for hand surgery that was performed under ultrasound guidance using bupivacaine and lidocaine. Due to its direct effect on nerve conduction of action potential, we propose that lithium may have had a role in the unusually prolonged duration of a peripheral nerve block.Keywords: nerve blockade, lithium, duration, anesthesia

  14. Immunotherapy and patients treated for cancer with microsatellite instability.

    Science.gov (United States)

    Colle, Raphaël; Cohen, Romain; Cochereau, Delphine; Duval, Alex; Lascols, Olivier; Lopez-Trabada, Daniel; Afchain, Pauline; Trouilloud, Isabelle; Parc, Yann; Lefevre, Jérémie H; Fléjou, Jean-François; Svrcek, Magali; André, Thierry

    2017-01-01

    Microsatellite instability (MSI) is a tumor phenotype linked to somatic or germline (Lynch syndrome) inactivating alterations of DNA mismatch repair genes. A broad spectrum of neoplasms exhibits MSI phenotype, mainly colorectal cancer, endometrial cancer, and gastric cancer. MSI tumors are characterized by dense immune infiltration and high load of tumor neo-antigens. Growing evidence is accumulating on the efficacy of immune checkpoint inhibition for patients treated for MSI solid tumors. We present a comprehensive overview of MSI phenotype, its biological landscape and current diagnostic methods. Then we focus on MSI as a predictive biomarker of response to immune checkpoint inhibition in the context of colorectal cancer and non-colorectal tumors.

  15. Extracorporeal shock waves as curative therapy for varicose veins?

    Directory of Open Access Journals (Sweden)

    Fiorenzo Angehrn

    2008-03-01

    Full Text Available Fiorenzo Angehrn1, Christoph Kuhn1, Ortrud Sonnabend2, Axel Voss31Klinik Piano, Biel, Switzerland; 2Pathodiagnostics, Herisau, Switzerland; 3SwiTech Medical AG, Kreuzlingen, SwitzerlandAbstract: In this prospective design study the effects of low-energy partially focused extracorporeal generated shock waves (ESW onto a subcutaneous located varicose vein – left vena saphena magna (VSM – are investigated. The treatment consisted of 4 ESW applications within 21 days. The varicose VSM of both sides were removed by surgery, and samples analyzed comparing the treated and untreated by means of histopathology. No damage to the treated varicose vein in particular and no mechanical destruction to the varicose vein’s wall could be demonstrated. However, an induction of neo-collagenogenesis was observed. The thickness of the varicose vein’s wall increased. Optimization of critical application parameters by investigating a larger number of patients may turn ESW into a non-invasive curative varicose treatment.Keywords: curative therapy, extra-cellular matrix (ECM, histopathologic changes of varicose veins, extracorporeal shock wave (ESW, progenitor cells

  16. Seizure Outcomes in Patients With Surgically Treated Cerebral Arteriovenous Malformations.

    Science.gov (United States)

    von der Brelie, Christian; Simon, Matthias; Esche, Jonas; Schramm, Johannes; Boström, Azize

    2015-11-01

    Epilepsy is the second most common symptom in cerebral arteriovenous malformation (AVM) patients. The consecutive reduction of life quality is a clinically underrated problem because treatment usually focuses on the prevention of intracerebral hemorrhage. To evaluate postoperative seizure outcome with the aim of more accurate counseling for postoperative seizure outcome. From 1985 to 2012, 293 patients with an AVM were surgically treated by J.S. One hundred twenty-six patients with preoperative seizures or epilepsy could be identified; 103 of 126 had a follow-up of at least 12 months and were included in the analysis. The different epilepsy subtypes were categorized (sporadic seizures, chronic epilepsy, drug-resistant epilepsy [DRE]). Preoperative workup and surgical technique were evaluated. Seizure outcome was analyzed by using International League Against Epilepsy classification. Sporadic seizures were identified in 41% of patients (chronic epilepsy and DRE were identified in 36% and 23%, respectively). Detailed preoperative epileptological workup was done in 13%. Seizure freedom was achieved in 77% (79% at 5 years, 84% at 10 years). Outcome was significantly poorer in DRE cases. More extensive resection was performed in 11 cases with longstanding symptoms (>24 months) and resulted in better seizure outcome as well as the short duration of preoperative seizure history. Patients presenting with AVM-associated epilepsy have a favorable seizure outcome after surgical treatment. Long-standing epilepsy and the progress into DRE markedly deteriorate the chances to obtain seizure freedom and should be considered an early factor in establishing the indication for AVM removal.

  17. Intubation of Profoundly Agitated Patients Treated with Prehospital Ketamine.

    Science.gov (United States)

    Olives, Travis D; Nystrom, Paul C; Cole, Jon B; Dodd, Kenneth W; Ho, Jeffrey D

    2016-12-01

    Profound agitation in the prehospital setting confers substantial risk to patients and providers. Optimal chemical sedation in this setting remains unclear. The goal of this study was to describe intubation rates among profoundly agitated patients treated with prehospital ketamine and to characterize clinically significant outcomes of a prehospital ketamine protocol. This was a retrospective cohort study of all patients who received prehospital ketamine, per a predefined protocol, for control of profound agitation and who subsequently were transported to an urban Level 1 trauma center from May 1, 2010 through August 31, 2013. Identified records were reviewed for basic ambulance run information, subject characteristics, ketamine dosing, and rate of intubation. Emergency Medical Services (EMS) ambulance run data were matched to hospital-based electronic medical records. Clinically significant outcomes are characterized, including unadjusted and adjusted rates of intubation. Overall, ketamine was administered 227 times in the prehospital setting with 135 cases meeting study criteria of use of ketamine for treatment of agitation. Endotracheal intubation was undertaken for 63% (85/135) of patients, including attempted prehospital intubation in four cases. Male gender and late night arrival were associated with intubation in univariate analyses (χ2=12.02; P=.001 and χ2=5.34; P=.021, respectively). Neither ketamine dose, co-administration of additional sedating medications, nor evidence of ethanol (ETOH) or sympathomimetic ingestion was associated with intubation. The association between intubation and both male gender and late night emergency department (ED) arrival persisted in multivariate analysis. Neither higher dose (>5mg/kg) ketamine nor co-administration of midazolam or haloperidol was associated with intubation in logistic regression modeling of the 120 subjects with weights recorded. Two deaths were observed. Post-hoc analysis of intubation rates suggested a

  18. 十全大补汤联合肠内营养支持对肺癌手术患者免疫功能及临床疗效的影响分析%Influence analysis of shiquandabu decoction combined with enteral nutrition on the immune function and clinical curative effect of patients with lung cancer

    Institute of Scientific and Technical Information of China (English)

    李宏

    2016-01-01

    目的:探讨十全大补汤联合肠内营养支持治疗肺癌手术患者的临床效果及免疫功能变化。方法:收治肺癌手术患者80例,随机分为两组。对照组单纯给予早期营养支持,研究组在营养支持的基础上加用十全大补汤治疗,比较两组临床疗效及免疫功能变化。结果:治疗后,研究组中医证候积分显著低于对照组,差异具有统计学意义(P<0.05)。研究组治疗后的免疫功能提高率显著高于对照组,降低率明显低于对照组,差异具有统计学意义(P<0.05)。结论:肠内营养支持联合十全大补汤治疗肺癌手术患者可有效提高临床效果,改善患者的免疫功能。%Objective:To investigate the clinical curative effect and changes of immune function of patients with lung cancer treated with shiquandabu decoction combined with enteral nutrition.Methods:80 cases of patients with lung cancer were divided into two groups randomly.The control group were treated with early nutritional support,and the research group were treated with shiquandabu decoction based on nutritional support.The clinical curative effect and changes of immune function of two groups were compared.Results:After treatment,the TCM syndrome scores of the research group were significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The immune function increasing rate of the research group was significantly higher than that of the control group,while the reduction rate was significantly lower than that of the control group, and the differences were statistically significant(P<0.05).Conclusion:Enteral nutrition combined with shiquandabu decoction in the treatment of patients with lung cancer could improve the clinical curative effect effectively and improve the immune function of the patients.

  19. Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Tomohiro; Kaneko, Kazuhiro; Makino, Reiko; Ito, Hiroaki; Konishi, Kazuo; Kurahashi, Toshinori; Kitahara, Tadashi; Mitamura, Keiji [Showa Univ., Tokyo (Japan). School of Medicine

    2001-05-01

    A significant correlation has been found between p53 mutation and response to chemotherapy or radiotherapy. To determine the prognostic value of p53 mutation in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy, p53 mutation was analyzed using the biopsied specimens taken for diagnosis. Concurrent chemoradiotherapy was performed for 40 patients with severe dysphagia caused by esophageal squamous cell carcinoma associated with T3 or T4 disease. Chemotherapy consisted of protracted infusion of 5-fluorouracil, combined with an infusion of cisplatinum. Radiation treatment of the mediastinum was administered concomitantly with chemotherapy. The p53 gene mutation was detected by fluorescence-based polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) methods. DNA sequences were determined for DNA fragments with shifted peaks by SSCP methods. Of the 40 patients, 15 had T3 disease and 25 had T4 disease; 11 patients had M1 lymph node (LYM) disease. Of the 40 patients, 13 (33%) achieved a complete response. The median survival time was 14 months, and the 2-year survival rate was 20%. Among the 40 tumor samples, p53 mutation was detected in 24 tumors (60%). The survival rate in the 24 patients with p53 mutation did not differ significantly from that in the 16 patients without p53 mutation. In contrast, the 15 patients with T3 disease survived longer than the 25 patients with T4 disease (P=0.016); however, the survival rate in the 11 patients with M1 LYM disease did not differ significantly from that in the 29 patients without M1 LYM disease. Concurrent chemoradiotherapy is potentially curative for locally advanced esophageal carcinoma, but p53 genetic abnormality has no impact on prognosis. (author)

  20. A case of progeria syndrome treated as VIP patient

    Directory of Open Access Journals (Sweden)

    Seema Mahant, Mahant PD, C.M. Reddy

    2014-11-01

    Full Text Available Progeria is rare autosomal recessive genetic disease with an incidence of about one in eight million. He was 16 years old boy lying on the couch. He was short stature thin with minimal subcutaneous tissue, skin was thin and fragile with loss of hair over scalp, eyebrows and eyelashes, and his face was dismorphic with prominent eyes, beaked nose, small jaw and large cranium with visible veins over it. His voice was thin and high pitched. Overall, this gives them an extremely aged nearly 70 -80 years old man look. The patient was a known case of progeria syndrome and he was treated as a VIP patient by all faculty members and staff, though he belongs low socioeconomic status, no political issue with them. But still he was a VIP.

  1. Fluctuating anaemia in treated HIV patients: could be a PICA?

    Science.gov (United States)

    Ajana, Faiza; Pasquet, Armelle; Auffret, Marine; Gautier, Sophie

    2013-01-01

    HIV infected patients are frequently exposed to anaemia, due to antiretroviral agents and/or prophylactic treatment of opportunistic infections. Anemia due to PICA, unusually evoked in our western countries, could be a more frequent situation than imagined. We report two cases of fluctuating anemia with no HIV or iatrogenic origin, observed in two HIV infected women, 47 years old and 33 years old respectively, coming from Africa and treated with antiretroviral agents. The anemia was explained by a culturally sanctioned practice of kaolin ingestion, in the broader context of PICA and resolved after the withdrawal of kaolin ingestion. PICA, and in particular kaolin ingestion, must be investigated when HIV infected patients came from Africa and presented significative unexplained anemia.

  2. 混合肠内营养支持对老年脑卒中患者的疗效观察%Curative observation of different enteral nutrition support in elderly stroke patients

    Institute of Scientific and Technical Information of China (English)

    梁倩芳

    2013-01-01

      目的探讨混合肠内营养(EN)支持对老年脑卒中患者营养状况的影响。方法将69例老年脑卒中患者随机分为观察组35例和对照组34例。观察组采用传统推注普通匀浆膳+持续输注能全力肠内营养混悬液,对照组采用传统推注普通匀浆膳。观察两组患者营养支持前后各项营养指标的变化并比较疗效。结果观察组营养支持后第7、14d总蛋白(TP)、白蛋白(ALB)、前白蛋白(PA)、血红蛋白(HGb)水平均明显高于对照组,差异有统计学意义(P <0.05)。结论采取传统推注匀浆膳加持续输注肠内营养混悬液的混合肠内营养支持方式,能增加老年脑卒中患者摄入量,提高血清蛋白水平,改善机体的营养状况。%  Objective To investigate the Curative observation of different enteral nutrition support in elderly stroke patients. Methods 69 cases with elderly stroke patients were randomly divided into observation group(n=35) and control group(n=34). Cases in observation group were treated enteral nutrition support with Nutrison Fibre and homogenate die, while cases in control group were treated with homogenate diet. Indicators of nutrition status were detected in two groups both before and after nutrition support, changes of all nutrition indicators of the two groups have been detected. Results Levels of TP, ALB, PA and HGb were significantly higher after receiving nutrition on the 7th and 14th day in observation group than those in control group(P <0.05). Conclusion Enteral nutrition support with Nutrison Fibre and homogenate diet can take in more protein and caloric, can improve nutritional status of elderly stroke patients.

  3. Audiological profile of patients treated for childhood cancer.

    Science.gov (United States)

    Liberman, Patricia Helena Pecora; Goffi-Gomez, Maria Valéria Schmidt; Schultz, Christiane; Novaes, Paulo Eduardo; Lopes, Luiz Fernando

    To characterize the hearing loss after cancer treatment, according to the type of treatment, with identification of predictive factors. Two hundred patients who had cancer in childhood were prospectively evaluated. The mean age at diagnosis was 6 years, and at the audiometric assessment, 21 years. The treatment of the participants included chemotherapy without using platinum derivatives or head and neck radiotherapy in 51 patients; chemotherapy using cisplatin without radiotherapy in 64 patients; head and neck radiotherapy without cisplatin in 75 patients; and a combined treatment of head and neck radiotherapy and chemotherapy with cisplatin in ten patients. Patients underwent audiological assessment, including pure tone audiometry, speech audiometry, and immittancemetry. The treatment involving chemotherapy with cisplatin caused 41.9% and 47.3% hearing loss in the right and left ear, respectively, with a 11.7-fold higher risk of hearing loss in the right ear and 17.6-fold higher in the left ear versus patients not treated with cisplatin (p<0.001 and p<0.001, respectively). Children whose cancer diagnosis occurred after the age of 6 have shown an increased risk of hearing loss vs. children whose diagnosis occurred under 6 years of age (p=0.02). The auditory feature found after the cancer treatment was a symmetrical bilateral sensorineural hearing loss. Chemotherapy with cisplatin proved to be a risk factor, while head and neck radiotherapy was not critical for the occurrence of hearing loss. Copyright © 2016 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

  4. 何氏逐阴散联合来氟米特治疗类风湿性关节炎临床疗效观察%Curative Effect of Combined Heshi-Zhuyin Powder and Leflunomide to Treat Rheumatoid Arthritis

    Institute of Scientific and Technical Information of China (English)

    周跃辉

    2012-01-01

    目的:观察何氏逐阴散和来氟米特联合应用治疗类风湿性关节炎临床疗效.方法:142例患者按就诊顺序采用随机排列表法分为治疗组和对照组,治疗组采用外敷何氏逐阴散和口服来氟米特,对照组外擦扶他林和口服来氟米特.结果:两组对于类风湿性关节炎均有效,但治疗组明显优于对照组.结论:何氏逐阴散外敷联合来氟米特治疗风湿性关节炎的疗效确切,能明显改善患者的临床症状与体征,值得推广.%Objective:To observe the curative effect of combined Heshi-Zhuyin Powder and Leflunomide for treating rheumatoid arthritis. Methods: All 142 patients of rheumatoid arthritis were randomly divided into treatment group and control group. The patients of treatment group were applyment outside with Heshi-Zhuyin Powder and taken orally with Leflunomide. Results:Both of the two groups were effective for rheumatoid arthritis, and the treatment group was significant superior to the control group. Conclusion; Heshi -Zhuyin Powder combined with Leflunomide are effective for rheumatoid arthritis, which can significantly improve the patient's clinical symptoms and signs, so t is worthy for clinical application.

  5. Application of cryoprecipitate in patients treated by portaazygous devascularization

    Directory of Open Access Journals (Sweden)

    YANG Zhaoxu

    2013-01-01

    Full Text Available ObjectiveTo evaluate the effect of cryoprecipitate-based blood component therapy on reducing perioperative risk in patients treated with portaazygous devascularization and to assess its influence on risk of post-operative complications. MethodsSixty-eight patients with portal hypertension who were scheduled for portaazygous devascularization were randomly assigned to receive either the standard surgery (control group, n=34 or surgery combined with perioperative transfusion of 10U cryoprecipitate (treatment group, n=34. Data recorded for inter-group comparative analysis (t-test included postoperative blood loss, prothrombin time, and recovery time, as well as incidences of re-hemorrhage in the gastrointestinal tract and of portal vein thrombosis. ResultsCompared with the control group, the cryoprecipitate-transfused patients showed significantly lower amount of blood loss after surgery and significantly lower incidence of postoperative bleeding and of re-hemorrhage in the gastrointestinal tract. The cryoprecipitate-transfused patients also experienced a shorter duration recovery period, with less days of in-hospital stay. There was no increase in the incidence of portal vein thrombosis after the use of cryoprecipitate. ConclusionApplication of cryoprecipitate during portaazygous devascularization surgery is safe and can improve coagulation function and reduce the risk of perioperative bleeding. Perioperative cryoprecipitate administration also benefits postoperative recovery and does not increase the incidence of portal vein thrombosis.

  6. Bone densitometry in pediatric patients treated with pamidronate

    Energy Technology Data Exchange (ETDEWEB)

    Grissom, Leslie E.; Kecskemethy, Heidi H.; Harcke, H.Theodore [Alfred I. duPont Hospital for Children, Nemours Children' s Clinic, Department of Medical Imaging, P.O. Box 269, Wilmington, DE (United States); Bachrach, Steven J. [Alfred I. duPont Hospital for Children, Nemours Children' s Clinic, Division of General Pediatrics, P.O. Box 269, Wilmington, DE (United States); McKay, Charles [Alfred I. duPont Hospital for Children, Nemours Children' s Clinic, Division of Nephrology, P.O. Box 269, Wilmington, DE (United States)

    2005-05-01

    To determine the effect of intravenous pamidronate on the bone mineral density of children with osteogenesis imperfecta and spastic quadriplegic cerebral palsy. Charts of 38 children with osteogenesis imperfecta (n=20) and spastic quadriplegic cerebral palsy (n=18) treated with pamidronate were retrospectively reviewed. Patients were selected for treatment because of prior fracture and/or abnormally low bone mineral density. All received intravenous pamidronate at two-month to eight-month intervals and were periodically examined using dual energy X-ray absorptiometry. All patients had abnormally low bone mineral density prior to treatment. Lumbar spine bone mineral density and z-scores showed serial improvement in 31 of 32 patients. Spine bone mineral density increased 78{+-}38.1% in OI and 47.4{+-}39.0% in children with cerebral palsy. The area of greatest lateral distal femur bone mineral density improvement was in the metaphysis adjacent to the growth plate, with a 96{+-}87.8% improvement in the osteogenesis imperfecta group and 65.7{+-}55.2% improvement in the cerebral palsy group. Increases in bone mineral density exceeded that expected for age-specific growth. This was demonstrated by improvement in both spine and femur z-scores for both groups. No children with spastic quadriplegic cerebral palsy experienced fractures after the first week of treatment, whereas patients with osteogenesis imperfecta continued to have fractures but at a decreased rate. (orig.)

  7. PCSK9 Inhibitors: Treating the Right Patients in Daily Practice.

    Science.gov (United States)

    King, Peta; Nicholls, Stephen J

    2017-08-01

    Monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9) have emerged as a novel approach to low-density lipoprotein cholesterol (LDL-C) lowering. The potential role of PCSK9 inhibitors in clinical practice will be reviewed. Clinical trials have demonstrated that PCSK9 inhibitors produce robust LDL-C lowering when administered either as monotherapy or in combination with statins. This provides the opportunity to achieve effective lipid lowering in familial hypercholesterolemia, patients with either established atherosclerotic cardiovascular disease or high risk primary prevention and an important opportunity to treat patients with statin intolerance. The findings from plaque imaging and patients with established atherosclerotic cardiovascular disease suggest that PCSK9 inhibition has favorable outcomes beyond improving lipid profiles, which has the opportunity to expand their use. PCSK9 inhibitors represent a new approach to achieving effective cardiovascular risk reduction in a broader number of patients. How these agents will be taken up in clinical practice remains to be determined.

  8. Curative Effects in General Massage Combined with Iliotibial Band Pressure Point Massage Treating Lumbar Disc Herniation%常规推拿手法合用髂胫束压痛点推拿治疗腰椎间盘突出症疗效

    Institute of Scientific and Technical Information of China (English)

    杨丽芳; 刘静; 罗凛

    2014-01-01

    Objective:To observe the clinical efficacy of general massage combined with iliotibial band pressure point massage treating lumbar disc herniation. Methods:68 patients with lumbar disc herniation were randomly divided into control group and treatment group, control group with rou-tine massage, treatment group received general massage combined with iliotibial band pressure point massage, to compare the curative effects of two groups. Results:The total effective rate of treatment group was 94.1%, significantly higher than that of control group by 73.5%(P<0.05). Conclu-sion:Efficacy of general massage combined with iliotibial band pressure point massage treating lumbar disc herniation is significant, being worthy of promotion.%目的:观察常规推拿手法合用髂胫束压痛点推拿治疗对腰椎间盘突出症的临床疗效。方法:68例腰椎间盘突出症的患者随机分为对照组与治疗组,对照组予常规推拿手法,治疗组予常规推拿手法合用髂胫束压痛点推拿松解,对比两组疗效。结果:治疗组总有效率为94.1%,显著高于对照组的73.5%(P<0.05)。结论:常规推拿手合用髂胫束压痛点推拿松解治疗腰椎间盘突出症疗效显著,值得推广。

  9. 探究通络祛痛膏治疗膝关节骨性关节炎风湿瘀阻证的疗效%To Explore the Curative Effect of Treating Knee Joint Osteoarthritis with Rheumatism and Blood Stasis Syndrome by Dredging Collaterals and Re-moving Pain Plaster

    Institute of Scientific and Technical Information of China (English)

    覃艳梅

    2016-01-01

    目的:探究治疗风湿瘀阻型KOA时应用通络祛痛膏的疗效。方法整群选择该院2014年2月—2016年3月收治的105例KOA患者作为临床疗效研究对象,依据随机数字表分为贴膏组55例(通络祛痛膏治疗)、参照组50例(应用塞来昔布),结果参照组总有效率为72.00%,贴膏组为92.73%;经过30 d的治疗后参照组的WOMAC评分明显高于贴膏组差异有统计学意义(P<0.05)。结论应用通络祛痛膏可以改善风湿瘀阻型KOA的治疗效果。%Objective To explore the therapeutic effect of dredging collaterals and relieving pain cream in treating rheumat-ic blood stasis type KOA. Methods Group choose in February 2014 — March 2016 from 105 cases of KOA patients in the hospital as the research object of the clinical curative effect, according to the random number table will be 105 points for plaster group 55 cases (Tongluo Qutong ointment in treating), reference group 50 cases (celecoxib). Results The reference group, the total efficiency was 72.00%, plaster group was 92.73%; after 30 d after treatment with reference to WOMAC score group was obviously higher than that in the plaster group (P< 0.05). Conclusion The application of dredging meridi-ans and removing pain ointment can improve the therapeutic effect of KOA in the treatment of rheumatism and blood stasis.

  10. Immunisation in a curative setting

    DEFF Research Database (Denmark)

    Kofoed, Poul-Erik; Nielsen, B; Rahman, A K

    1990-01-01

    OBJECTIVE: To study the uptake of vaccination offered to women and children attending a curative health facility. DESIGN: Prospective survey over eight months of the uptake of vaccination offered to unimmunised women and children attending a diarrhoeal treatment centre as patients or attendants...... of women and children who were unimmunised or incompletely immunised was calculated and the percentage of this target population accepting vaccination was recorded. RESULTS: 7530 (84.2%) Of 8944 eligible children and 7730 (40.4%) of 19,138 eligible women were vaccinated. Of the children, 63.8% were boys......, 75.9% were aged under 1 year, and 23.0% were aged 1 to 2 years. The estimated number of missed opportunities for vaccination was 716 among the children (8.0% of the target population) and 11,408 among the women (59.6% of those eligible). CONCLUSION: It is possible to establish immunisation services...

  11. Curative observation on treating secretory otitis media in children by secretory excision%腺样体切除治疗小儿分泌性中耳炎疗效观察

    Institute of Scientific and Technical Information of China (English)

    王红杰

    2013-01-01

    Objective To discuss the mechanism, time and curative effects in treating secretory ostitis media in children by secretory excision. Methods 78 children admitted into our hospital from July 2010 to July 2012 were selected and diagnosed to be secretory ostitis media because of secretory hypertrophy, among those, 42 received surgery treatment and 36 got non surgery treatment. We compared the treatment effects for those two methods. Results The total efifciency for surgery treatment was 96.62%, and the total efifciency for non surgery treatment was 83.33%, there was great dififdence for the two kind of treatment methods. Conclusion It is beneift for function recovery of eustachian tube, audition improvement after the secretory excision. And the relapse rate is very low, so it is an efifcient method for the treatment of secretory ostitis media in children.%目的:探讨腺样体切除治疗小儿分泌性中耳炎的机理、时机及疗效。方法选择保定市第二医院2010年7月至2012年7月间收治并确诊为腺样体肥大所致分泌性中耳炎患儿78例,其中手术治疗42例、非手术治疗36例,对比分析采用两种方法的治疗效果。结果手术组治疗后总有效率97.62%,非手术组治疗后总有效率83.33%,两组治疗后有效性差异有统计学意义。结论腺样体切除术后有利于咽鼓管功能恢复、听力改善,术后复发率低,是治疗儿童分泌性中耳炎的有效方法。

  12. Malignancies in patients treated with high doses of radium-224

    Energy Technology Data Exchange (ETDEWEB)

    Nekolla, E.A. [Federal Office for Radiation Protection (BfS), Neuherberg (Germany); Walsh, L. [Radiobiological Inst., Univ. of Munich (Germany); Schottenhammer, G.; Spiess, H. [Children' s Hospital, Univ. of Munich (Germany)

    2005-07-01

    Several thousand German patients suffering from ankylosing spondylitis, tuberculosis and some other diseases, received multiple injections of the short-lived {alpha}-emitter {sup 224}Ra. The ''Spiess study'' was initiated in the early 1950s to follow the health of 899 persons (278 female, 621 male) who were treated mainly between 1945 and 1955. Most of the high dose patients and nearly all of those treated as children or juveniles (n=217) were included in the study. In June 2003, 152 persons were still alive. The most striking observed health effect, following {sup 224}Ra injections, was a temporal wave of 56 malignant bone tumours with a maximum at about 8 years after exposure which has already been described in several publications. In 2000, a new analysis was performed because an improved dosimetry resulted in modified bone surface doses. The estimated risk coefficient, averaged over all ages at exposure, was found to be in agreement with earlier analyses. However, a statistically significant increase of bone tumour risk with decreasing age at exposure was found. The earlier results, which indicated a reversed protraction factor, were confirmed. A significant excess of non-skeletal solid malignancies has also appeared during the most recent observation decade. In 2004, significant increases of cancer rates were observed for several sites: for breast cancer (31 cases observed vs. 9.1 cases expected), soft tissue malignancies (11 vs. 1.0), thyroid carcinomas (7 vs. 0.9), liver (8 vs. 2.3), kidney (13 vs. 4.6), pancreas (8 vs. 3.9), and bladder cancer (14 vs. 7.7). The 8-fold excess relative risk of mammary cancers in those women exposed as children or juveniles is particularly striking; moreover, 2 cases of breast cancer occurred in men. In 1993, a control group of tuberculosis patients not treated with {sup 224}Ra was established to rule out potential confounding factors - such as chest fluoroscopy - which might bias the breast cancer excess

  13. Oligo-recurrence predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lung cancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional study of 61 subjects.

    Science.gov (United States)

    Niibe, Yuzuru; Nishimura, Tetsuo; Inoue, Tetsuya; Karasawa, Katsuyuki; Shioyama, Yoshiyuki; Jingu, Keiichi; Shirato, Hiroki

    2016-08-19

    To investigate the prognostic value of oligo-recurrence in patients with brain-only oligometastases of non-small cell lung cancer (NSCLC) treated with stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT). Patients treated with SRS or SRT for brain-only NSCLC oligometastases in 6 high-volume institutions in Japan between 1996 and 2008 were reviewed. Eligible patients met 1), 2), and 4) or 1), 3), and 4) of the following: 1) NSCLC with 1 to 4 brain metastases on magnetic resonance imaging (MRI) treated with SRS or SRT; 2) control of the primary lesions (thorax) at the time of SRS or SRT for brain metastases (patients meeting this criterion formed the oligo-recurrence group); 3) with SRS or SRT for brain metastases, concomitant treatment for active primary lesions (thorax) with curative surgery or curative stereotactic body radiotherapy (SBRT), or curative chemoradiotherapy (sync-oligometastases group); and 4) Karnofsky performance status (KPS) ≥70. The median overall survival (OS) of all 61 patients was 26 months (95 % CI: 17.5-34.5 months). The 2-year and 5-year overall survival rates were 60.7 and 15.7 %, respectively. Stratified by oligostatus, the sync-oligometastases group achieved a median OS of 18 months (95 % CI: 14.8-21.1 months) and a 5-year OS of 0 %, while the oligo-recurrence group achieved a median OS of 41 months (95 % CI: 27.8-54.2 months) and a 5-year OS of 18.6 %. On multivariate analysis, oligo-recurrence was the only significant independent factor related to a favorable prognosis (hazard ratio: 0.253 (95 % CI: 0.082-0.043) (p = 0.025). The presence of oligo-recurrence can predict a favorable prognosis of brain-only oligometastases in patients with NSCLC treated with SRS or SRT.

  14. Cancer risk in patients with spondyloarthritis treated with TNF inhibitors

    DEFF Research Database (Denmark)

    Hellgren, Karin; Dreyer, Lene; Arkema, Elizabeth V.

    2017-01-01

    TNFi initiators with SpA, RR versus TNFi-naïve was 0.8 (95% CI 0.7 to 1.0) and results were similar for AS and PsA when analysed separately. Site-specific cancer RRs: prostate 0.5 (95% CI 0.3 to 0.8), lung 0.6 (95% CI 0.3 to 1.3), colorectal 1.0 (95% CI 0.5 to 2.0), breast 1.3 (95% CI 0.9 to 2......Background Safety data on cancer risks following tumour necrosis factor a inhibitors (TNFi) in patients with spondyloarthritis (SpA) (here defined as ankylosing spondylitis (AS), undifferentiated spondarthropaties (SpA UNS), psoriatic arthritis (PsA)) are scarce. Our objective was to assess risks...... for cancer overall and for common subtypes in patients with SpA treated with TNFi compared with TNFi-naïve patients with SpA and to the general population. Methods From the Swedish (Anti-Rheumatic Therapy in Sweden (ARTIS)) and Danish (DANBIO) biologics registers, we assembled 8703 (ARTIS=5448, DANBIO=3255...

  15. Treatments of Hepatocellular Carcinoma Patients with Hepatitis B Virus Infection: Treat HBV-related HCC

    Directory of Open Access Journals (Sweden)

    Charing Ching-Ning Chong

    2016-03-01

    Full Text Available There have been major advances recently on the therapeutic approaches of hepatitis B virus (HBV-related hepatocellular carcinoma (HCC. Surgical treatments are the key curative treatments of HCC, whereas local ablative treatments may also achieve clinical remission in selected cases. Trans-arterial locoregional therapies are regarded as palliative but still lead to improved survival. There have been major breakthroughs in the systemic therapies for HCC. The first marketed targeted therapy, sorafenib, was shown to improve survival in patients with advanced HCC. Studies on other targeted therapies also showed promising results. Suppressing HBV with effective antiviral treatment would also benefit HCC patients by reducing recurrence and improving liver function.

  16. 外用中药面膜及左旋维生素C联合穴位注射丹参治疗黄褐斑疗效观察%Analysis of traditional Chinese medicine mask and levorotatory vitamin C for Joint Chiefs of Danhe curative effect of acupoint injection in treating chloasma

    Institute of Scientific and Technical Information of China (English)

    潘丽萍

    2015-01-01

    目的:观察外用中药面膜及左旋维生素C联合穴位注射丹参治疗黄褐斑的临床疗效。方法:将60名黄褐斑患者分为A、B两组,A组(治疗组):背部俞穴注射丹参联合中药面膜及左旋维生素C治疗;B组(对照组):用中药面膜联合左旋维生素C治疗。以VISIA面部棕色斑评分法及传统评价法(评分计算法)评价两组有效率,并进行对比分析。结果:A组的临床总有效率为98%,B组的临床总有效率96%(P>0.05),两组比较无统计学意义。A组基本治愈率高于B组,VISIA面部棕色斑评分法与评分计算法结果与此结果相当。结论:外用中药面膜及左旋维生素C联合穴位注射丹参治疗黄褐斑的临床疗效很好,不良反应较少,成本较低,经济实惠,风险小,可临床推广应用。%Objective To observe the clinical curative effect of external application by Chinese herbal medicine mask and levorotatory vitamin C combined with acupoint injection of Danshen in treating chloasma. Method 60 patients with chloasma were divided into A, B two groups,group A (treatment group) was treated by Shu-acupoint back injection of Danshen combined with traditional Chinese medicine mask and levorotatory vitamin C;group B (control group)was treated with traditional Chinese medicine combined with vitamin C in facial mask.VISIA facial brown spot scoring method and the traditional evaluation method (score calculation) were used to evaluate the efficiency of two groups and compared the results. Results The clinical A group total effective rate was 98%, the clinical total effective rate was 96% in B group(P>0.05),there was no statistical significance.A group basic cure rate and effective rate was higher than that of group B,VISIA score and the score of facial brown spot and the results calculated by equivalent. Conclusion The clinical curative effect of external application of Chinese herbal medicine mask and levorotatory

  17. Ovarian structural disturbances in epilectic patients treated with Sodium valproate

    Directory of Open Access Journals (Sweden)

    Yousefi N.

    2008-03-01

    Full Text Available Background: Recent studies have raised the issue of an increased incidence of polycystic ovaries (PCO and menstrual disturbances in women with epilepsy treated with valproate (VPA. It seems that antiepileptic drugs, especially valproate, may have a functional role in altering the endocrine system of child-bearing women with epilepsy. We conducted this study to investigate the association of VPA and ovarian structural/menstrual disorders in epileptic women.Methods: In this cross-sectional study, we compared a total of 64 epileptic patients, aged 16-45 years, 32 of whom had been taking VPA alone and 32 were on other antiepileptic drugs for a minimum duration of six months. Ovarian sonography was performed and body mass index (BMI calculated for all subjects. We also recorded the presence of menstrual disturbances in both groups.Results: Fifteen (46% of the VPA subjects had PCO compared to 7 (21.9% of the other group. In the VPA group, four (12.5% had oligomenorrhea, one (3.1% amenorrhea and 13 (40.6% had irregular menstrual cycles. However, from the other group, two (6.3% subjects had oligomenorrhea and seven (21.9% had irregular menstrual cycles; amenorrhea was not present in the non-VPA treated patients. Mean BMI was 22.5 kg/m2 among the VPA subjects and 20.1 kg/m2 in the non-VPA subjects.Conclusions: This study supports the association of PCO and high BMI with VPA treatment. The frequency of menstrual disturbances did not differ significantly between the two groups.

  18. Severe hypercalcemia and hypernatremia in a patient treated with canagliflozin

    Science.gov (United States)

    Winters, Stephen J

    2015-01-01

    Summary Drugs that inhibit the sodium-glucose co-transporter-2 (SGLT2) are an exciting novel, insulin-independent treatment for diabetes that block glucose reabsorption from the proximal tubules of the kidney, leading to increased glucose excretion and lower blood glucose levels. Inhibition of SGLT2 activity also reduces sodium reabsorption, which together with glycosuria produces a mild diuretic effect with the potential for dehydration and hyperkalemia. We report on a 60-year-old man with uncontrolled type 2 diabetes treated with insulin, glimepiride, metformin and canagliflozin, who was admitted with altered mental status after a syncopal episode. He had a 1-week history of ingestion of Tums for heartburn followed by poor appetite and lethargy. Laboratory work-up showed acute kidney injury, diabetic ketoacidosis (DKA), and parathyroid hormone-independent severe hypercalcemia of 17.4 mg/dl. DKA resolved with insulin treatment, and saline hydration led to improvement in hypercalcemia and renal function over 48 h, but was accompanied by a rapid increase in the serum sodium concentration from 129 to 162 mmol/l despite changing fluids to 0.45% saline. Urine studies were consistent with osmotic diuresis. Hypernatremia was slowly corrected with hypotonic fluids, with improvement in his mental status over the next 2 days. This is the first report of hypercalcemia associated with the use of a SLGT2 inhibitor. Although the exact mechanism is unknown, canagliflozin may predispose to hypercalcemia in patients ingesting excessive calcium because of dehydration from osmotic diuresis, with reduced calcium excretion and possible increased intestinal calcium absorption. Saline therapy and osmotic diuresis may lead to hypernatremia from electrolyte-free water loss. Learning points Canagliflozin, an SGLT2 inhibitor, may cause hypercalcemia in susceptible patients.Although the exact mechanisms are unknown, dehydration from osmotic diuresis and increased intestinal calcium

  19. 中药外治法用于盆腔炎性疾病后遗症的疗效探讨%Exploring the curative effect of treating sequelae of pelvic inflammatory disease with chinese medicine external therapy

    Institute of Scientific and Technical Information of China (English)

    宁林金; 朱颖源; 奉新英; 尹小桃

    2011-01-01

    Objective To explore the curative effect of treating sequelae of pelvic inflammatory disease with chinese medicine external therapy.Metbods 178 cases that diagnosed as sequelae of pelvic inflammatory disease were randomly divided into control group,test Group 1,and test Group 2.Control group were treated by with broad-spectrum antibioticos for three cycles cycles intravenously;and applying Chinese medicine retention enema and Chinese medicine abdominal hot compress on test Group 1 for three cycles;test Group 2 was used the same methods as group 1 for six cycles.Comparing the comprehensive effect,cure rate and the recurrence rate within the six-month after the treatment.Results Comparing the integrated effect of the three groups;test groups 2 was the optimal(P<0.01).The cure rates of control group,test Group 1,and test Group 2 were19%34%61%respective;and the recurrence rates were 55%,35%,12%respectively.There were statistically significant differences among these three groups(P<0.01);test group 2 had the highest cure rate and the lowest recurrence rate;and control group had the opposite results.Conchusion Applying Chinese medicine retention enema and abdominal Chinese medicine hot compress on sequelae of pelvic inflammatory disease for 6 cycles has remarkable treatment effect.%目的 探讨中药外治法治疗湿热瘀阻型盆腔炎性疾病后遗症的临床疗效.方法 选择178例确诊为湿热瘀阻型盆腔炎性疾病后遗症的女性,随机分为对照组、试验1组和试验2组.对照组采用广谱抗生素静脉滴注3个疗程,试验1组采取中药保留灌肠加中药腹部外敷治疗3个疗程.试验2组与试验1组同法治疗6个疗程.比较三组的综合疗效.治愈率及停药后6个月内的复发率.结果 三组综合疗效比较,试验2组综合疗效最优,差异有极显著性(P<0.01).对照组、试验1组和试验2组的治愈率分别为19%.34%,61%;停药后6个月内的复发率分别为55%.35%,12%;三组治愈率和复

  20. 氧气驱动雾化吸入治疗小儿毛细支气管炎的疗效观察%Oxygen aerosol inhalation to treat infantile capil ary bronchitis curative ef ect observation

    Institute of Scientific and Technical Information of China (English)

    肖菊霞

    2015-01-01

    objective:to study the oxygen aerosol inhalation in the treatment of infantile capil ary bronchitis curative ef ect and nursing care.Methods:126 cases of capil ary bronchitis patients were randomly divided into observation group and control group.The control group,62 cases of the conventional comprehensive treatment with traditional way of ultrasonic atomization in-halation.Observation group 64 cases on the basis of routine comprehensive treatment,give driven by oxygen atomization inhalation.Results:in observation group,the blood oxygen saturation, symptoms and signs disappeared time,the cure rate is bet er than that in control group (P <0.01).Conclusion:oxygen aerosol inhalation in the treatment of infantile capil ary bronchitis meth-od is bet er than that of ultrasonic atomization inhalation,can shorten the course of the disease,relieve pain,children promote children recover at an early date,is worth promoting.%目的:探讨氧气驱动雾化吸入治疗小儿毛细支气管炎的疗效和护理。方法:将126例毛细支气管炎患儿随机分为观察组和对照组。对照组62例采用常规综合治疗,运用传统的超声雾化吸入方式。观察组64例在常规综合治疗的基础上,给予由氧气驱动雾化吸入方式。结果:观察组在血氧饱和度、症状及体征消失时间、治愈率等方面优于对照组(P <0.01)。结论:氧气驱动雾化吸入治疗小儿毛细支气管炎的方法优于超声雾化吸入方式,可缩短病程,减轻患儿痛苦,促进患儿早日康复,值得推广。

  1. 骨水泥型人工股骨头置换治疗老年不稳定股骨转子间骨折%Curative effects using cemented artificial femoral head arthroplasty for unstable intertrochanteric fracture in elderly patients

    Institute of Scientific and Technical Information of China (English)

    吕浩; 荆珏华; 周云

    2013-01-01

    Objective To explore the clinical effect of artificial femoral head arthroplasty on unstable intertrochanteric fracture of femur in the elderly patients.Methods 17 cases of the femoral neck fractures in elderly patients was treated with bone cement prosthetic femoral head replacement and intertrochanteric reconstruction.The patients did earliest rehabilitation exercise after operation.Results The operation time was 55 ~ 95min,the intraoperative blood loss was 100 ~500 ml.1 case got involved deep vein thrombosis in lower limb.17 cases were followed up for 8 ~ 21 months.According to the final Harris hip function score,8 cases were excellent,6 good,2 fair,and 1 poor.Conclusions Cemented prosthetic femoral head replacement in the treatment of intertrochanteric femoral fractures can shorten the time in bed,reduce the complications,provide early stage of hip functional exercise to rehabilitation.The curative effect is reliable.%目的 探讨人工股骨头置换治疗老年不稳定股骨转子间骨折的临床效果.方法 对17例老年不稳定股骨转子间骨折患者行骨水泥型股骨头置换及转子间重建,术后早期进行功能锻炼.结果 手术时间55~95 min,术中出血量100~500 ml.1例术后出现下肢静脉血栓.17例均获随访,时间8~21个月.末次随访髋关节功能Harris评分:优8例,良6例,可2例,差1例.结论 应用骨水泥人工股骨头置换治疗不稳定股骨转子间骨折,可缩短患者卧床时间,减少并发症发生;早期进行患髋功能锻炼,有利于康复,且疗效可靠.

  2. Curative effect of decitabine combined with CAG regimen in older patients with acute myeloid leukemia%地西他滨联合CAG治疗老年急性髓系白血病的疗效观察

    Institute of Scientific and Technical Information of China (English)

    于锦香; 蔡冬梅; 王晓雪; 梁颖; 张蕊; 颜晓菁; 何娟; 李艳

    2013-01-01

    目的 观察地西他滨联合CAG方案治疗老年急性髓系白血病的疗效和安全性.方法 7例老年急性髓系白血病患者应用地西他滨+ CAG方案[地西他滨15 mg/(m2·d),qd,iv,d1-5;阿克拉霉素10 mg/d,qd,iv,d3-6;阿糖胞苷10 mg/m2,q12h,ih,d3-9;G-CSF 300μg,qd,ih d0-9].观察患者疗效及不良反应.结果 2例使用4个疗程,2例使用3个疗程,1例使用2个疗程,2例使用1个疗程,其中2例获完全缓解,4例获部分缓解,1例疾病进展,最后因肺部感染死亡.结论 地西他滨联合CAG方案治疗老年急性髓系白血病,效果良好,安全性高,不良反应少,化疗相关死亡率低.%Objective To investigate the curative effect and safety of decitabine combined with CAG regimen treatment for elderly AML patients. Methods 7 cases of elderly AML patients were treated with decitabine combined with CAG regimen [decitabine 15 mg/(m2?d) ,qd,iv,d1-5 ,aclarubicin 10 mg/d, qd, iv, d3-6 , Ara-c 10 mg/m2 ,ql2h, ih, d3-9 , G-CSF 300 μg, qd, ih, d0.9]. Results 2 cases lasted for 4 courses, and 2 cases for 3 courses, 1 case for 2 courses and 2 cases for 1 course. There were 2 cases of CR,4 cases of PR,1 case of NR(died of lung infection). Conclusion Decitabine combined with CAG regimen is an effective treatment for the elderly AML patients with high safety and low treatment-related mortality.

  3. With LPHP PHILOS beloved or the curative effect of complex treatment of proximal humeral fractures older patients%采用PHILOS与LPHP治疗老年肱骨近端复杂骨折的疗效研究

    Institute of Scientific and Technical Information of China (English)

    叶文清

    2014-01-01

    Objective To analysis in the proximal humerus locking system (PHILOS beloved or) locking plate with a locking proximal humeral plate (LPHP) in the treatment of proximal humerus elderly the curative effect of complex fractures. Method 96 cases of complex proximal humerus elderly fracture patients were randomly divided into two groups, observation group with PHILOS beloved or locking plate internal ifxation treatment, control group using LPHP internal ifxation treatment, compared two groups of curative effect. Result The average healing time of fracture (6.5±3.5) for weeks, the control group (8.2±3.9) for weeks, the experimental group earlier than the control group (t=2.247, P=0.027). Lift on precursor observation group, outside readings is greater than the control group (t=2.691, P=0.008;t=3.088, P=0.003);curative effect observation group was 95.84%, 81.25%in control group, experimental group is better than that of control group (Z=-2.103, P=0.035);observation group 6.25%incidence of adverse reactions, control group was 12.50%, no statistically signiifcant differences between the two groups (χ2cor ection = 0.490, P = 0.483). Conclusion Proximal humerus elderly complex fracture were treated by PHILOS beloved or locking plate reduction and ifxation, early activities of curative effect is better than that of LPHP, and side effects of small, have important reference value.%目的:分析肱骨近端内锁定系统(PHILOS)自锁钢板与肱骨近端锁定钢板(LPHP)治疗老年肱骨近端复杂骨折的效果。方法将96例老年肱骨近端复杂骨折患者随机均分为两组,观察组患者采用PHILOS自锁钢板内固定治疗,对照组患者采用LPHP内固定治疗,比较两组的治疗效果。结果观察组患者骨折平均愈合时间为(6.5±3.5)周,对照组患者骨折平均愈合时间为(8.2±3.9)周,观察组早于对照组(t=2.247,P=0.027);观察组患者前驱上举、外旋度

  4. Nigerian dental students' willingness to treat HIV-positive patients.

    Science.gov (United States)

    Azodo, Clement Chinedu; Ehigiator, Osarobo; Oboro, Helen Oziofu; Ehizele, Adebola Oluyemisi; Umoh, Agnes; Ezeja, Ejike Bartholomew; Omili, Michael; Ehigiator, Laura

    2010-04-01

    Dental care of HIV-positive individuals plays a vital role in improving their nutritional intake, medication tolerance and effectiveness, treatment success rate, and quality of life. It is therefore important to ensure optimal dental care of this group of people, especially since more of them, with or without knowledge of their serologic status, are now utilizing dental services. The objective of this study was to assess Nigerian dental students' willingness to treat HIV-positive individuals. A descriptive cross-sectional survey of all seventy-six final-year dental students of the University of Benin, Nigeria, was conducted in December 2007 using a self-administered questionnaire that elicited information on the students' demography, self-rated knowledge on HIV/AIDS, attitude towards homosexuals, infection control practices, occupational risk perception, and willingness to provide care for HIV-positive individuals. The response rate was 76.3 percent. Over 77 percent of the respondents were in the twenty-five to thirty years age group. The male-female ratio was approximately 1.6:1. HIV-related knowledge was reported as high by only 31 percent of the respondents. Eighty-one percent showed great interest in HIV-related information, while about half (53.4 percent) exhibited significant worry about occupational contagion. Forty-eight (82.7 percent) desired more knowledge about safety precautions during treatment of HIV patients. Fifty respondents (86.2 percent) reported good infection control practices. About three-fourths (74.2 percent) rated the risk of HIV contagion from patients high, while only one-fourth (25.8 percent) reported having an unsympathetic attitude towards homosexuals. Almost all respondents (98.3 percent) agreed that oral care for HIV-positive individuals improves their quality of life, but only 58.8 percent expressed a willingness to treat HIV-positive patients and only 46.5 percent said they will render volunteer dental services in HIV centers. HIV

  5. The curative effects of therapy of Jieyu mixture coordinating with cognitive behavior on treating PSD%解郁合剂配合认知行为疗法治疗卒中后抑郁疗效分析

    Institute of Scientific and Technical Information of China (English)

    孔莉; 颜红

    2011-01-01

    [目的]探讨解郁合剂配合认知行为疗法治疗卒中后抑郁的临床疗效.[方法]将128例卒中后抑郁患者依照随机数字表法分为治疗组(解郁合剂配合认知行为疗法组)和对照组(西酞普兰组),其中治疗组68例,对照组60例,所有患者均于治疗前、治疗4周及治疗8周分别进行汉密尔顿抑郁量表(HAMD)、副反应量表(TESS)评分比较.[结果]采用解郁合剂配合认知行为疗法可明显减少患者HAMD评分,改善患者抑郁状态,其效果优于单纯西药治疗(P<0.05),且副反应小.[结论]解郁合剂配合认知行为疗法治疗卒中后抑郁症安全有效,适合临床推广.%[Objective] To probe the clinical efficacy of therapy of Jieyu mixture coordinating with cognitive behavior on treating PSD. [Method] Divide 128 patients with PSD into two groups, 68 cases of treatment group (treated with Jieyu mixture coordinating with cognitive behavior), and 60 cases of control group (treated with citaloprm). All of the patients were graded at before treating, 4 and 8 weeks after treating by HAMD and TESS scale. [Result] The therapy of Jieyu mixture coordinating with cognitive behavior could reduce the HAMD, and improve the depressive state of PSD patients, and better than citaloprm. [Conclusion] The therapy of Jieyu mixture coordinating with cognitive behavior can be safety and effective to treat PSD, and suit to popularize.

  6. Biomarkers in patients treated with BCG: an update.

    Science.gov (United States)

    Klap, Julia; Schmid, Marianne; Loughlin, Kevin R

    2014-08-01

    Bacillus Calmette-Guerin (BCG) instillations are the recommended treatment for non-muscle invasive bladder cancer but high recurrence and progression rates remain after treatment. Despite patients risk stratification, BCG effectiveness remains unpredictable. A close, invasive and expensive follow up is mandatory. To improve or even replace this heavy surveillance in this high risk population, validated biomarkers were developed. To identify the useful tools for the urologist in monitoring bladder cancer patients, we reviewed the literature focusing on plasma and urinary biomarkers of BCG-therapy outcome. Articles dated from 1988 to 2013 including specific keywords (urinary bladder neoplasm, biological markers, intravesical administration, recurrence) were examined and relevant papers were selected. Before treatment initiation, genetic polymorphisms of multiple agents (cytokines, matrix-metalloproteinases) were found to become very useful to tailor therapy and monitoring. Those biomarkers belong to personalized medicine which is a topic of great interest today, but still need to be validated in cohorts from different ethnicities. During instillations, cytokines (IL-2, IL-8, IL-6/IL-10) were reported to be reliable to determine treatment response and efficacy. Further studies are needed to confirm results and standardize thresholds. After treatment, UroVysion, the FDA-approved fluorescence in situ hybridization (FISH), appeared to be the most robust marker of all the clinical parameters reviewed; but is not yet validated for BCG-treated patients. No recommendations for everyday practice can be established today, but a combination of several markers and clinicopathological characteristics may be the future. As bladder cancer diagnosis and management are evolving, practicing urologists should be aware of and utilize bladder cancer markers in clinical practice.

  7. Vitamin B12 status in metformin treated patients: systematic review.

    Directory of Open Access Journals (Sweden)

    Qilin Liu

    Full Text Available OBJECTIVE: Randomized controlled trials and observational studies have yielded inconsistent results on the effects of metformin on vitamin B12 reduction. We therefore performed a systematic review to analyze the effects of metformin on vitamin B12 concentration. METHODS: PubMed, Medline, Embase, and the Cochrane central registry of controlled trials were searched to identify randomized controlled trials and observational studies exploring the association between metformin and vitamin B12 concentration in patients with type 2 diabetes mellitus or polycystic ovary syndrome. The main outcome measure was changes in serum vitamin B12 concentration after 6-208 weeks of treatment with metformin, as compared with placebo or other anti-hyperglycemic therapy. RESULTS: Six randomized controlled trials met the inclusion criteria. Serum vitamin B12 concentrations were significantly lower in patients treated with metformin than in those who received placebo or rosiglitazone (mean difference [MD], -53.93 pmol/L; 95% confidence interval [CI], -81.44 to -26.42 pmol/L, P = 0.0001. Subgroup analysis identified four trials in which patients received a lower dose of metformin (<2000 mg/d and two in which they received a higher dose (≥2000 mg/d, with MDs in vitamin B12 concentration after metformin treatment of -37.99 pmol/L (95% CI, -57.44 to -18.54 pmol/L, P = 0.0001 and -78.62 pmol/L (95% CI, -106.37 to -50.86 pmol/L, P<0.00001, respectively. CONCLUSIONS: The reduction of vitamin B12 may be induced by metformin in a dose dependent manner.

  8. Lipoprotein Kinetics in Male Hemodialysis Patients Treated with Atorvastatin

    Science.gov (United States)

    Schwaiger, Johannes P.; Nakada, Yoshinobu; Berberich, Ramona; Ikewaki, Katsunori; Dieplinger, Benjamin; Zitt, Emanuel; Neyer, Ulrich; Salmhofer, Hermann; Kronenberg, Florian; Koenig, Paul

    2013-01-01

    Summary Background and objectives In vivo metabolism of atherogenic apolipoprotein B (apoB)–containing lipoproteins is severely impaired in patients undergoing hemodialysis (HD), resulting in markedly prolonged residence times of these particles. It is unclear whether treatment with statins improves LDL kinetics in HD patients as is known for the general population. Therefore, this kinetic study assessed apoB-containing lipoproteins in these patients. Design, setting, participants, & measurements Kinetic measures were analyzed with stable-isotope technology in six men undergoing HD before and after 3 months of daily administration of 10 mg of atorvastatin. Patients were 18–65 years of age, had LDL cholesterol levels between 90 and 200 mg/dl, and had been treated with HD for >6 months. They consumed a standardized isocaloric diet for 3 days before analysis. Fractional catabolic rates (FCRs) and production rates of very-low-density lipoprotein (VLDL)–apoB, intermediate-density lipoprotein–apoB, and LDL-apoB were determined using multicompartment modeling after plasma lipoprotein separation, precipitation of apoB, and determination of tracer-to-tracee ratios using mass spectrometry. Results Plasma concentrations of VLDL- and LDL-apoB were significantly lower (mean ± SD, 7.77±2.62 versus 11.27±6.15 mg/dl, P<0.05; 56.9±23.9 versus 84.0±21.1 mg/dl, P=0.03) and their FCRs were significantly higher (7.20±3.08 versus 5.20±2.98 days−1, P<0.05; 0.851±0.772 versus 0.446±0.232 days−1, P<0.05) after 3 months of atorvastatin treatment. Accordingly, the residence times in plasma of VLDL- and LDL-apoB were significantly lower after treatment (0.14 versus 0.19 day and 1.2 versus 2.2 days, respectively). Conclusion Lower plasma concentrations and improved kinetics of atherogenic lipoproteins were observed in HD patients after administration of low-dose atorvastatin. PMID:23599405

  9. Aortic thrombus in a patient with myeloproliferative thrombocytosis, successfully treated by pharmaceutical therapy: a case report

    Directory of Open Access Journals (Sweden)

    Imai Norikazu

    2010-07-01

    Full Text Available Abstract Introduction Thrombosis in myeloproliferative thrombocytosis occurs usually in the microvessels and medium-sized arteries and veins and only rarely in the aorta. Aortic thrombosis is usually treated with thrombectomy. Reported here is a rare case that was treated pharmacologically. Case presentation A 60-year-old Japanese woman presented with numbness of both lower extremities. Her platelet count was 1787 × 103/μl. Through bone marrow examination, we diagnosed her condition as myelodysplastic and/or myeloproliferative disorder-unclassifiable. Abdominal ultrasonography and computed tomographic scan revealed aortic thrombosis. Her platelet count was controlled with hydroxyurea and ranimustine. Aspirin and ticlopidine improved the numbness in both lower limbs on the second day. Aortic thrombosis was not observed in a computed tomographic scan on the seventh day. Conclusion For aortic thrombosis, surgical management is usually adopted, but pharmacological management is also an option because of its immediate curative effects.

  10. Effect of Operation Time on the Curative Efficacy in Hypertensive Intracerebral Hemorrhage in Basal Ganglia Treating With Small Window Craniotomy Microsurgical Operation%小骨窗显微手术时机对基底节区高血压性脑出血疗效的影响

    Institute of Scientific and Technical Information of China (English)

    李建; 高觉民

    2014-01-01

    Objective To investigate the effect of operation time on the curative efficacy in hypertensive intracerebral hemorrhage (HICH) in basal ganglia treating with small window craniotomy microsurgical operation. Methods 80 cases of HICH in basal ganglia treating with small window craniotomy microsurgical operation meeting the inclusion criteria were randomly divided into ultra-early group (within 6 h) and early group (6~24 h) equally. Then the curative efficacy and life quality scores were observed and compared. Results The rate of recurrent hemorrhage in the ultra-early group was 10.0%, which was statistically same with that of 15.0% in the early group (P>0.05). Meanwhile, the ultra-early group had a mortality rate of 5.0%, which was statistically lower than that of 20.0% in the early group (P0.05). Three months after, life quality scores in the ultra-early group was significantly statistically higher than that in the early group (P<0.05). Conclusion The ultra-early small window craniotomy microsurgical operation can significant reduce mortality rate of patients with HICH in basal ganglia, improve life quality and prognosis, without increasing the rate of recurrent hemorrhage. And the ultra-early operation time is ideal for patients with optimum conditions.%目的:探讨小骨窗显微手术时机对基底节区高血压性脑出血(HICH)疗效的影响。方法80例符合纳入标准的行小骨窗显微手术的基底节区 HICH 患者随机分为超早期组(发病6 h 内手术)和早期组(发病6~24 h 内手术),每组各40例,观察治疗疗效及患者生活质量评分变化情况。结果超早期组和早期组的再出血率分别为10.0%和15.0%,两组比较无统计学差异(P >0.05)。超早期组的手术死亡率为5.0%,明显低于早期20.0%的死亡率,比较有统计学差异(P <0.05)。术前,两组患者生活质量评分比较无统计学差异(P >0.05)。术后3个月,超早期组的生活质量

  11. 高强度超声聚焦治疗晚期胰腺癌20例的疗效分析%a Study about Curative Effect of High Intensity Focused Ultrasound on 20 Patients with advanced Pancreatic Cancer

    Institute of Scientific and Technical Information of China (English)

    张涛; 刘在照

    2013-01-01

    Objective To investigate the efficacy and security of High Intensity Focused Ultrasound (HIFU) in treating patients with advanced pancreatic carcinoma. Methods 20 newly received cases of advanced pancreatic carcinoma with HIFU was treated. The curative effect of HIFU was observed by testing the function of major organs, examining the tumor volume changes with CT and ultrasound, and observing the serum level of CA19-9, CA242 and other indicators. Results After treatment, the pain symptoms were relieved significantly in nearly 85% of the patients. Results of 7-21d imaging examination showed that compared with patients before treatment, tumor volume in 9 cases (45%) was decreased, in 8 cases (40%) was almost changeless and in 3 cases (15%) was increased among patients after treatment. Results of CT enhanced scan showed that tumors in 6 cases did not have significant enhancement and in 14 cases had regional enhancement. The latter indicated the existence of blood flow and suggested that tumors had not been destroyed by heat and more treatment were needed. The concentration of biochemical markers such as CA19-9、CA242 was decreased and no significant complications were appeared in patients after treatment in the near future. Conclusion As a safe treatment method, HIFU treatment can significantly relieve sufferings, improve life quality and extend life span of patients with advanced pancreatic carcinoma.%  目的探讨高强度超声聚焦(HIFU)对晚期胰腺癌患者治疗的效果和安全性。方法对近期收治的20例晚期胰腺癌患者应用高能超声聚焦刀治疗。通过主要脏器功能测定,超声及CT检查肿瘤体积变化,通过血清标志物CA19-9、CA242等指标的测定观察HIFU的疗效。结果治疗后85%的患者癌性疼痛症状得到了较大缓解;7-21 d影像学检查显示:与治疗前相比,治疗后肿瘤体积缩小的有9例,占45.00%;无明显变化的有8例,占40.00%;增大的有3例,占15.00%

  12. Role of preoperative selective portal vein embolization in two-step curative hepatectomy for hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Wu Ji; Jie-Shou Li; Ling-Tang Li; Wu-Hong Liu; Kuan-Sheng Ma; Xiang-Tian Wang; Zhen-Ping He; Jia-Hong Dong

    2003-01-01

    AIM: To determine the feasibility and role of ultrasoundguided preoperative selective portal vein embolization (POSPVE) in the two-step hepatectomy of patients with advanced primary hepatocellular carcinoma (HCC).METHODS: Fifty patients with advanced HCC who were not suitable for curative hepatectomy were treated by ultrasound-guided percutaneous transhepatic POSPVE with fine needles. The successful rate, side effects and complications of POSPVE, changes of hepatic lobe volume and two-step curative hepatectomy rate after POSPVE were observed.RESULTS: POSPVE was successfully performed in 47(94.0 %) patients. In patients whose right portal vein branches were embolized, their right hepatic volume decreased and left hepatic volume increased gradually. The ratio of right hepatic volume to total hepatic volume decreased from 62.4 % before POSPVE to 60.5 %, 57.2 %and 52.8 % after 1, 2 and 3 weeks respectively. The side effects included different degree of pain in liver area (38cases), slight fever (27 cases), nausea and vomiting (9cases). The level of aspartate alanine transaminase (AST),alanine transaminase (ALT) and total bilirubin (TBIL)increased after POSPVE, but returned to preoperative level in 1 week. After 2-4 weeks, two-step curative hepatectomy for HCC was successfully performed on 23 (52.3 %) patients.There were no such severe complications as ectopic embolization, local hemorrhage and bile leakage.CONCLUSION: Ultrasound-guided percutaneous transhepatic POSPVE with fine needles is feasible and safe. It can extend the indications of curative hepatectomy of HCC, and increase the safety of hepatectomy.

  13. Curative Treatment of Stage I Non-Small-Cell Lung Cancer in Patients With Severe COPD: Stereotactic Radiotherapy Outcomes and Systematic Review

    Energy Technology Data Exchange (ETDEWEB)

    Palma, David, E-mail: david.palma@uwo.ca [VU University Medical Center, Amsterdam (Netherlands); Division of Radiation Oncology, London Regional Cancer Program, London, Ontario (Canada); Lagerwaard, Frank [VU University Medical Center, Amsterdam (Netherlands); Rodrigues, George [Division of Radiation Oncology, London Regional Cancer Program, London, Ontario (Canada); Haasbeek, Cornelis; Senan, Suresh [VU University Medical Center, Amsterdam (Netherlands)

    2012-03-01

    Objectives: Patients with severe chronic obstructive pulmonary disease (COPD) have a high risk of lung cancer and of postsurgical complications. We studied outcomes after stereotactic body radiotherapy (SBRT) in patients with severe COPD, as defined by Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, and performed a systematic review of the literature on outcomes after SBRT or surgery in these patients. Methods: A single-institution cohort of 176 patients with COPD GOLD III-IV and Stage I non-small-cell lung cancer (NSCLC) treated with SBRT was evaluated. A systematic review identified studies reporting outcomes after SBRT or surgery for Stage I NSCLC in patients with GOLD III-IV or a predicted postoperative forced expiratory volume in 1 second (FEV1) of {<=}40%. Results: In the single-institution cohort, median follow-up was 21 months and median overall survival (OS) was 32 months. Actuarial 3-year local control was 89%, and 1- and 3-year OS were 79% and 47%, respectively. COPD severity correlated with OS (p = 0.01). The systematic review identified four other studies (two surgical, two SBRT, n = 196 patients). SBRT studies were published more recently and included older patients than surgical studies. Mean 30-day mortality was 0% post-SBRT and 10% after surgery. Local or locoregional control was high ({>=}89%) after both treatments. Post-SBRT, actuarial OS was 79-95% at 1 year and 43-70% at 3 years. Postsurgical actuarial OS was 45-86% at 1 year and 31-66% at 3 years. Conclusions: SBRT and surgery differ in risk of 30-day mortality in patients with severe COPD. Despite the negative selection of SBRT patients, survival at 1 and 3 years is comparable between the two treatments.

  14. Observation of Curative Effect on Patients of Chronic Rhinosinusitis with Xinzhi Naristillae%辛芷滴鼻液对慢性鼻-鼻窦炎患者的疗效观察

    Institute of Scientific and Technical Information of China (English)

    王萍; 刘光斌; 代得银

    2015-01-01

    Objective To observe the clinical curative effect of Xinzhi Naristillae on treating the patients which were CRSwNP or CRSsNP.Methods Choose 598 case of CRS patients in our hospital from March 2012 to March 2014.They were randomly divided into a control group and Xinzhi Naristillae group.The control group was given thearapy of flutica-sone propionate and roxithromycin.In addition to above, the other group was given three drops Xinzhi Naristillae on each nose and three times a day.Each group were given score with VAS and SNOT-20 before treatment and the fourth, eighth,12th, 16th after treatment.Results The score of VAS and SNOT-20 between control group and Xinzhi Naristil-lae group decreased compared with the score before treatment, and Xinzhi Naristillae group significantly decreased.The difference was statistically significant.Conclusions Xinzhi Naristillae have a therapeutic effect on CRS.%目的:观察辛芷滴鼻液治疗慢性鼻-鼻窦炎( Chronic rhinosinusitis,CRS)伴或不伴息肉( CRSwNP or, CRSsNP)患者的临床疗效。方法选择2012年3月~2014年3月诊治慢性鼻鼻窦炎患者598例,随机分为对照组及辛芷滴鼻液组,对照组给予丙酸氟替卡松、罗红霉素治疗;辛芷滴鼻液组除上述治疗外给予辛芷滴鼻液滴鼻每鼻3滴,1日3次;每组于治疗前和治疗4、8、12、16周分别给予视觉模拟评分法( Visual Analogue Scale/Score,简称VAS)及鼻腔鼻窦结局测试-20( SNOT-20)评分。结果对照组及辛芷滴鼻液组VAS评分及SNOT-20评分较治疗前降低,且辛芷滴鼻液组降低更明显,差异具有统计学意义。结论辛芷滴鼻液对慢性鼻-鼻窦炎有治疗作用。

  15. 抑郁患者治疗前后疗效评价方法的研究进展%Research advance on evaluation method of curative effect in patient with depression before and after treatment

    Institute of Scientific and Technical Information of China (English)

    冯玙; 武志芳

    2015-01-01

    Depression has high prevalence,high self-mutilation,high recurrence rate,high mortality,do harm to human health seriously.After antidepressant treatment,we usually use Hamilton depression scale to assess whether the treat-ment is effective.With the development of new technology,in-depth research and the appearance of new testing method, it is possible to find a more objective and specific evaluation method for the depression patient.At present,for the eval-uation of the efficacy before and after treatment,researchers have studied the change of scale,cytokines,EEG,MEG, functional MRI,diffusion tensor imaging,cerebral blood flow,glucose metabolism and the receptor imaging.The study re-views the different evaluation methods of curative effect before and after treatment for patients with depression.%抑郁症有高患病率、高自残率、高复发率、高死亡率的特点,是一类严重危害人类身心健康的疾病。在抗抑郁治疗后,临床上常用汉密尔顿抑郁量表来评价治疗是否有效。随着新技术的发展、研究的深入、新型检测手段的出现,使找到一个更加客观、更加特异地评价抑郁疗效的检查方式成为可能。目前对于抑郁症治疗前后疗效的评价,研究者们研究了治疗前后量表、细胞因子、脑电信号、脑磁图、功能磁共振、弥散张量成像、脑局部血流量、葡萄糖代谢、神经受体等多方面的改变,得到不同的评价结果。本研究就目前抑郁患者治疗前后疗效的不同评价方法进行综述。

  16. Curative effects of nasal lacrimal sac anastomosis combined with tube insertion under nasal endoscope on patients with chronic dacryocystitis and nasolacrimal duct obstruction

    Directory of Open Access Journals (Sweden)

    Hao Sun

    2017-03-01

    Full Text Available AIM: To explore the effects of nasal lacrimal sac anastomosis combined with tube insertion under nasal endoscope on patients with chronic dacryocystitis and nasolacrimal duct obstruction. METHODS: Totally 70 patients(70 eyeswith chronic dacryocystitis and nasolacrimal duct obstruction in our hospital from December 2011 to December 2014 were selected, and were randomly divided into control group and study group. The control group were treated with nasal cavity lacrimal sac anastomosis under nasal endoscope, and the study group were treated with nasal lacrimal sac anastomosis combined with tube insertion under nasal endoscope. Total effective rates and fistula areas at 1, 6 and 12mo before and after operation were compared between the two groups. RESULTS: At 1mo after operation, there was no significant difference in total effective rates between the control group(97%and the study group(100%; P>0.05. At 6mo after operation, the total effective rate in the study group(97%was significantly higher than that in the control group(77%; PPP>0.05, while fistula areas in the study group were larger than those in the control group at 6 and 12mo after operation(PCONCLUSION: The effects of nasal lacrimal sac anastomosis combined with tube insertion under nasal endoscope on patients with chronic dacryocystitis and nasolacrimal duct obstruction are remarkable.

  17. The mechanisms of photodynamic action for treating of cancer patients

    Directory of Open Access Journals (Sweden)

    A. L. Akopov

    2015-01-01

    Full Text Available Current views on mechanisms of therapeutic effect of photodynamic therapy for treating of cancer patients are represented. The history of formation and development of the method is described. The main requirements for agents used as photosensitizers are listed. Detailed review of main photosensitizers used in clinical practice in Russia and in foreign countries with their chemical structure, main spectral characteristics was performed. Methods of its application, therapeutic dose ranges, indications, specifi c pharmacokinetic properties and side-effects are briefl y outlined. Advantages and disadvantages of the most popular modern photosensitizers, main mechanisms of entry of photosensitizers of different chemical structure into cancer cells are observed. Three main possible component of anti-tumor effect: direct damage of cancer cells, impairment of vascular stroma of tumor and elimination of tumor due to immune cells are shown and closely discussed. Necrosis and apotosis of neovascular net which are main development trends of anti-tumor action for photodynamic therapy are noticed. 

  18. [Holter monitoring of patients treated with cytostatic agents].

    Science.gov (United States)

    Kozáková, M; Beńesová, E; Cieslar, P; Sálková, J

    1989-01-20

    After cytostatic treatment severe arrhythmias, the development of angina pectoris and even the development of acute myocardial infarction and sudden death were observed. Therefore we made in 42 patients with malignant haematological disease treated with cytostatics 96 Holter monitorings of the electrocardiographic signal. The monitoring was made during the administration of cytostatics as well as during the time interval between the administration of combinations of cytostatics. In both instances (during the administration and during the interval between administration) we recorded a surprisingly high, mean all-day as well as maximal, heart rate. In the group monitored during administration of chemotherapeutic drugs we observed 5-8 hours after administration of cytostatics serious ventricular arrhythmias [incl. ventricular tachycardia], denivelization of the ST segment, paroxysms of supraventricular tachycardia. In the group monitored during the interval between administration of cytostatics the sick-sinus syndrome was recorded, as well as a passive nodal rhythm, disorders of the intraventricular conduction. The described changes are explained by the release of vasoactive substances after administration of cytostatics, by a change of the transmembrane calcium transport leading to an increased excitability of the heart muscle and possibly to coronary spasms and direct irreversible damage of the conduction system.

  19. Meta analysis on curative effect of oxiracetam improving cognitive function of patients with acute cerebral apoplexy%奥拉西坦改善急性脑卒中患者认知功能疗效的Meta分析

    Institute of Scientific and Technical Information of China (English)

    万玉鸿; 李继

    2015-01-01

    Objective To evaluate effect and safety of oxiracetam treating cognitive function of patients with acute cerebral apoplexy. Methods retrieve Pubmed, Cochrane Library, CNKI, VIP and Wanfang database by computer, search random control test (RCT) of oxiracetam treating cognitive function of patients with acute cerebral apoplexy, and screen references included in documents with retrieval time of inception to December 2012. Carry on Meta analysis by RevMan 5 software after 2 researchers’ screening and drawing materials according to predetermined inclusion and exclusion criteria, and quality evaluation of methodology. Resultsa total of 9 RCT were included . Meta analysis results showed:difference between placebo and oxiracetam with mini mental state examination table (MMSE) and Barthel index rating value of improving acute cerebral apoplexy showed statistical significance. Eight reports on adverse reactions incidence of oxiracetam treating acute cerebral apoplexy showed no statistical difference from placebo group, with slight adverse reaction degree and no serious adverse reaction, which is safe in clinical application.Conclusion present study showed oxiracetam has good curative effect and safety for improving cognitive function of patients with acute cerebral apoplexy. And the above results have to be confirmed yet by more high-quality studies.%目的:评价奥拉西坦治疗急性脑卒中患者认知功能的疗效及安全性。方法计算机检索Pubmed、Cochrane图书馆、CNKI、VIP和万方数据库,查找奥拉西坦治疗急性脑卒中患者认知功能的随机对照试验(RCT),同时筛检纳入文献的参考文献。检索时间均从建库至2012年12月。由2名研究者按预定纳入与排除标准筛选文献、提取资料和进行方法学评价质量后,采用RevMan 5.0软件进行Meta分析。结果共纳入9个RCT。Meta分析结果显示:与安慰剂相比,奥拉西坦在改善急性脑卒中患者简易精神状态检查

  20. Curative effect analysis of different blood purification way for severe arsenic poisoning patients%不同血液净化方式对重症砷中毒患者疗效分析

    Institute of Scientific and Technical Information of China (English)

    何招辉; 杨春丽

    2014-01-01

    Objective To explore the curative effect of continuous bedside blood filter treatment and continuous bedside blood filter combined with the plasma exchange on the patients with multiple organ dysfunction caused by arsenic poisoning. Metheds To analyze 8 cases of severe arsenic poisoning patients retrospectively which were acceptted in hospital from January 2010 to February 2012,they were divided randomly into two groups,4 cases of the treatment group were treated with continuous bedside blood filter treatment,the others with continuous bedside blood filter combined with the plasma exchange. Through the change of clinical symptoms,hemoglobin,liver and kidney function,urine volume,and the time of in hospital of ICU,we compared and ob-served the patient's condition. Results Such as ausea,vomiting,waist pain,abdominal pain and so on clinical symptoms were all can obviously relieve after continuous bedside blood purification treatment on the two groups of patients. After the seventh day , serum creatinine,bilirubin,myocardial enzyme have improved significantly compare with before treatment. But there were no obvi-ous difference between the two groups in the time of the urine recovery time,ICU length of hospital stay and total length of hospital stay. Conclusion Early be treated with continuous bedside blood filter treatment or continuous bedside blood filter combined with plasma exchange,the prognosis of the severe arsenic poisoning patients with multiple organ function can obviously be improved. And there was no obvious difference between the two kinds of treatment methods on the prognosis.%目的:探讨持续床旁血滤治疗与持续床旁血滤联合血浆置换治疗对存在多器官功能不全的砷中毒患者的疗效。方法回顾性分析2010年1月至2012年2月我科收治的8例重症砷中毒患者治疗,将其随机分两组。其中治疗组4例行持续床旁血滤治疗,对照组4例行床旁血滤联合血浆置换治疗。比较观察患

  1. How much does curation cost?

    Science.gov (United States)

    Karp, Peter D

    2016-01-01

    NIH administrators have recently expressed concerns about the cost of curation for biological databases. However, they did not articulate the exact costs of curation. Here we calculate the cost of biocuration of articles for the EcoCyc database as $219 per article over a 5-year period. That cost is 6-15% of the cost of open-access publication fees for publishing biomedical articles, and we estimate that cost is 0.088% of the cost of the overall research project that generated the experimental results. Thus, curation costs are small in an absolute sense, and represent a miniscule fraction of the cost of the research.

  2. The curative effect analysis of acetabulum fracture treated with bridge combined fixation sys-tem or reconstruction plate%桥接组合式内固定系统与重建钢板治疗髋臼骨折的疗效比较

    Institute of Scientific and Technical Information of China (English)

    关翔; 宋香全; 王洪炳; 周朝波

    2015-01-01

    Objective To investigate the clinical efficacy of reconstruction plate or bridge combined fixation system in the treatment of acetabulum fractures. Methods Fifty-five patients of acetabulum fractures treated by surgery were selected for a case-control study. Twenty-eight patients was treated by reconstruction plate, while twenty-seven pa-tients was treated by bridge combined fixation system. Operation time, intraoperative blood loss and hospital stay of two groups were observed and compared. Results The time of hospital stay, operative time, amount of bleeding of the group treated by bridge combined fixation system was better than the group treated by reconstruction plate. There are statistically significant difference between the two groups (P<0. 05). For the postoperative hip joint function of the reconstruction plate group,14 cases were excellent,9 good,4 fair, and 1 poor, and the rate of excellence and good results was 23/28. For the bridge combined fixation system group,13 cases were excellent,11 good,2 fair, and 1 poor, and the rate of excellence and good results was 24/27. There are statistically significant difference between the two groups of curative effect ( P<0. 05 ) . Conclusions The bridge combined fixation system has the advantages of less trauma, better functional recovery and less postoperative complications, which can be used as the preferred way for the surgical treatment of acetabulum fracture.%目的:探讨重建钢板与桥接组合式内固定系统治疗髋臼骨折临床疗效。方法手术治疗55例髋臼骨折的患者,分别行重建钢板(28例)和桥接组合式内固定系统(27例)内固定,观察两组的手术时间、术中出血量、住院时间,比较两组疗效。结果桥接组合式内固定系统组的手术时间、术中出血量、住院时间均优于重建钢板组,差异有统计学意义(P<0.05)。术后髋关节功能:重建钢板组优14例,良9例,可4例,差1例,优良率23/28;桥接

  3. Curative Analysis of Applying Traditional Chinese Medicine Characteristic Symptomatic Therapy to Treat Sudden Deafness%中医辨证治疗突发性耳聋临床疗效分析

    Institute of Scientific and Technical Information of China (English)

    唐嘉蔚; 佘国跃; 谭伟

    2014-01-01

    目的:分析中医特色对症治疗突发性耳聋的临床疗效,探索突发性耳聋治疗方法.方法:以100例突发性耳聋患者为研究对象,随机将其分为观察组与对照组各50例,给予对照组西医治疗,给予观察组中医特色对症治疗,比较两组听力损失分值总和、耳鸣变化状况及疗效.结果:治疗后,观察组平均听力损失分值总和为72分,对照组为93分,与治疗前相比,均有统计学意义(P<0.05);治疗后,组间比较差异有统计学意义(P<0.05).治疗后,观察组与对照组耳鸣状况均改善,与治疗前相比,差异显著(P<0.05);治疗后组间差异显著(P<0.05).观察组治疗总有效率为94%,对照组为78%,组间差异显著(P<0.05).结论:中医特色对症疗法是治疗突发性耳聋的可靠方法,值得临床推广.%Objective:To study the effect of TCM characteristic symptomatic therapy in the treatment of sudden deafness,and to explore the treatment methods of sudden deafness.Methods:100cases of sudden deafness patients were selected as the research object,they were randomly divided into two groups:the observation group and the controlled group,each group of 50cases.The controlled group were given western medicine therapy,the observation group were given TCM characteristic symptomatic therapy,making a comparison of two groups of hearing loss sum score,changes in tinnitus and curative effect.Results:After treatment,the sum scores of the average heating loss in the observation group was 72,and the controlled group was 93,compared with before treatment,there were statistically significant (P<0.05) ; after treatment,the difference between the two groups was statistically significant (P<0.05).After treatment,both group of tinnitus status were improved,compared with before treatment,the difference was significant (P<0.05) ; the differences between the two groups was significant after treatment (P<0.05).The total efficiency of the observation group was 94

  4. 动脉持续灌注化疗与静脉全身化疗治疗中晚期胰腺癌的疗效分析%A clinical study on continuous transarterial infusion chemotherapy and systemic venous chemotherapy with gemcitabine and 5-fiuorouracil in treating patients with advanced pancreatic carcinoma

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To compare the curative effectiveness of continuous transarterial infusion chemotherapy and systemic venous chemotherapy in treating patients with advanced pancreatic cancer, and to evaluate the value of selective continuous transarterial infusion chemotherapy in treating advanced pancreatic cancer. Methods: Of the 51 patients with advanced pancreatic cancer receiving chemotherapy with gemcitabine and 5-fluorouracil, 25 patients were treated with selective continuous transarterial infusion chemotherapy, 26 were treated with systemic venous chemotherapy, and curative effectiveness was analyzed retrospectively. Curative effectiveness included tumor volume, clinical benefit response (CBR), acute and subacute toxic reactions of antitumor drugs, survival rate and median survival time. Results: The objective effective rate in transarterial group was 32.0% versus 23.1% in systemic group without any significant difference (P = 0.475). Clinical benefit rates in transarterial group and systemic group were 80.0% and 50.0% respectively (P = 0.025). The 6-, 9- and 12-month accumulated survival rates and median survival time in transarterial group were higher than those of the systemic group (P = 0.002), the differences were statistically significant. However, the adverse reactions between the two groups were not statistically significant. Conclusion: Compared with systemic chemotherapy, continuous transarterial infusion chemotherapy with gemcitabine and 5-fluorouracil could improve clinical benefit rate and survival time of patients with advanced pancreatic cancer, it is safe and reliable, and the adverse reactions is less.

  5. Risk of virus-associated cancer in female arthritis patients treated with biologigal DMARDs

    DEFF Research Database (Denmark)

    Cordtz, René; Mellemkjær, Lene; Glintborg, Bente;

    2016-01-01

    .0) cancer only occurred among bDMARD-treated patients. SIR was not increased for cervical cancer, either in ever or never bDMARD-treated patients. SIRs for Hodgkin's and non-Hodgkin's lymphomas were increased in never bDMARD-treated patients (SIR = 2.5, 95% CI: 1.5, 4.0). CONCLUSION: bDMARD therapy...... was not associated with an overall excess of virus-associated cancers in female arthritis patients. The observed increased occurrence of oropharyngeal cancer needs further investigation. Lymphoma incidence was increased in patients unexposed to bDMARD treatment.......OBJECTIVE: To investigate the risk of virus-associated cancer in female arthritis patients ever treated with biological DMARDs (bDMARDs) compared with never bDMARD-treated patients and ever and never treated with bDMARD compared with the general population. METHODS: This was a cohort study...

  6. Observation of Clinical Curative Effect of Transmultifidus Lumbar Interbody Fusion in the Treat-ment of Lumbar Degenerative Diseases%经多裂肌间隙椎间融合术治疗腰椎退行性疾病观察

    Institute of Scientific and Technical Information of China (English)

    赵建; 刘少; 林波; 刘丽平

    2014-01-01

    Objective To investigate and analyze the clinical curative effect of transmultifidus lumbar interbody fusion in the treatment of lumbar degenerative diseases. Methods 62 patients with lumbar degenerative diseases who came to our hos-pital from April,2011 to July,2012 were randomly divided into the control group and the experimental group according to the random number method. There were 31 cases in each group. The control group accepted transforaminal lumbar interbody fusion while the experimental group accepted transmultifidus lumbar interbody fusion. The clinical curative effect of the two groups was compared. Results Blood loss and postoperative drainage volume of the experimental group was significantly less than that of the control group(P0. 05). The VAS score in the 3rd day and 2 weeks after the operation,the ODI index in 1st month and 6th month of the experimental group was statistically better than that of the control group(P0. 05). Conclusion Transmultifidus lumbar interbody fusion has a significant effect in treating lumbar degenerative diseases. The approach has less damage during the operation and improves the efficacy of surgery and patients'quality of life. So it is worth promoting.%目的:探讨分析经多裂肌间隙入路椎体间融合治疗腰椎退行性疾病的临床疗效。方法选取我院自2011年4月至2012年7月收治的62例腰椎退行性疾病患者,将所有患者按随机数法分为实验组和对照组,各31例。对照组接受经椎间孔椎体间融合术,实验组接受经多裂肌间隙椎间融合术,对比分析两组患者的临床疗效。结果实验组术中出血量及术后引流量均明显少于对照组( P0.05),实验组术后3 d,术后2周的VAS评分及术后1个月与术后半年的ODI评分明显优于对照组( P0.05);实验组与对照组手术前及术后1年滑脱角、椎间隙高度及Taillard指数的比较差异无统计学意义( P>0.05)。结论经多裂肌间隙入路

  7. Personalised medicine in asthma: from curative to preventive medicine.

    Science.gov (United States)

    Guilleminault, Laurent; Ouksel, Hakima; Belleguic, Chantal; Le Guen, Yannick; Germaud, Patrick; Desfleurs, Emilie; Leroyer, Christophe; Magnan, Antoine

    2017-01-01

    The concept of asthma has changed substantially in recent years. Asthma is now recognised as a heterogeneous entity that is complex to treat. The subdivision of asthma, provided by "cluster" analyses, has revealed various groups of asthma patients who share phenotypic features. These phenotypes underlie the need for personalised asthma therapy because, in contrast to the previous approach, treatment must be tailored to the individual patient. Determination of the patient's asthma phenotype is therefore essential but sometimes challenging, particularly in elderly patients with a multitude of comorbidities and a complex exposure history. This review first describes the various asthma phenotypes, some of which were defined empirically and others through cluster analysis, and then discusses personalisation of the patient's diagnosis and therapy, addressing in particular biological therapies and patient education. This personalised approach to curative medicine should make way in the coming years for personalised preventive and predictive medicine, focused on subjects at risk who are not yet ill, with the aim of preventing asthma before it occurs. The concept of personalised preventive medicine may seem a long way off, but is it really? Copyright ©ERS 2017.

  8. Q开关Nd:YAG激光治疗色素性皮肤病421例%Pigmented Dermatosis Treated with Q-Switched Nd:YAG Laser and Its Clinical Curative Effect

    Institute of Scientific and Technical Information of China (English)

    王立玉; 行敏; 党艳秋

    2011-01-01

    Objective To observe therapeutic effect and safety of pigmented dermatosis treated with Q-switched Nd:YAG laser.Methods A total of 421 patients with pigmented dermatosis were treated with Q-switched Nd: YAG laser, including 103 cases of freckle, 45 cases of cafe-au-lait spots, 98 cases seborrheic keratosis, 33 cases of naevus of Ora, 56 cases of tattoos(blue and black), 49 cases of naevus fuscocaerulens zygomaticus and 37 cases of accidental chromatosis.The pigmented dermatosis was treated with wavelength of 532 nm the freckle, cafe-au-lait spots and seborrheic keratosis were treated with wavelength of 532 nm and 1 064 nm while the naevus of Ota, tattoos ( blue and black), naevus fuscocaerulens zygomaticus and accidental chromatosis were treated with wavelength of 1 064 nm.Results After treated 1 to 9 times, the total effective rate of freckle, cafe-au-lait spots, seborrheic keratosis , the naevus of Ota, tattoos(blue and black), nacvus fuscocaerulens zygomaticus and accidental chromatosis was 96.1%, 75.6%, 70.4%, 78.8%,91.1%, 81.6% and 83.8%, respectively.There was no scar formation.Conclusions Q-switched Nd:YAG laser is proved to be safe and effective in treating pigmented dermatosis.%目的 观察Q开关Nd:YAG激光治疗色素性皮肤病的临床疗效及安全性.方法 使用Q开关Nd:YAG激光治疗色素性皮肤病患者421例,其中雀斑103例、咖啡斑45例、脂溢性角化病98例、太田痣33例、文身(蓝黑色)56例、颧部褐青色痣49例及外伤性色素沉着37例.激光治疗的波长:雀斑、咖啡斑为532nm,脂溢性角化病为532 nm和1 064 nm波长联合治疗,太田痣、文身(蓝黑色)、颧部褐青色痣和外伤性色素沉着采用Q1 064 nm波长.结果 经1-9次治疗,雀斑、咖啡斑、脂溢性角化病、太田痣、文身(蓝黑色)、颧部褐青色痣及外伤性色素沉着总有效率分别为96.1%、75.6%、70.4%、78.8%、91.1%、81.6%和83.8%.术后出现暂时性色素沉着25例(5.9%),无

  9. The Preoperative Controlling Nutritional Status Score Predicts Survival After Curative Surgery in Patients with Pathological Stage I Non-small Cell Lung Cancer.

    Science.gov (United States)

    Shoji, Fumihiro; Haratake, Naoki; Akamine, Takaki; Takamori, Shinkichi; Katsura, Masakazu; Takada, Kazuki; Toyokawa, Gouji; Okamoto, Tatsuro; Maehara, Yoshihiko

    2017-02-01

    The prognostic Controlling Nutritional Status (CONUT) score is used to evaluate immuno-nutritional conditions and is a predictive factor of postoperative survival in patients with digestive tract cancer. We retrospectively analyzed clinicopathological features of patients with pathological stage I non-small cell lung cancer (NSCLC) to identify predictors or prognostic factors of postoperative survival and to investigate the role of preoperative CONUT score in predicting survival. We selected 138 consecutive patients with pathological stage I NSCLC treated from August 2005 to August 2010. We measured their preoperative CONUT score in uni- and multivariate Cox regression analyses of postoperative survival. A high CONUT score was positively associated with preoperative serum carcinoembryonic antigen level (p=0.0100) and postoperative recurrence (p=0.0767). In multivariate analysis, the preoperative CONUT score [relative risk (RR)=6.058; 95% confidence interval (CI)=1.068-113.941; p=0.0407), increasing age (RR=7.858; 95% CI=2.034-36.185; p=0.0029), and pleural invasion (RR=36.615; 95% CI=5.900-362.620; pcancer-specific survival (CS), and overall survival (OS), the group with high CONUT score had a significantly shorter RFS, CS, and OS than did the low-CONUT score group by log-rank test (p=0.0458, p=0.0104 and p=0.0096, respectively). The preoperative CONUT score is both a predictive and prognostic factor in patients with pathological stage I NSCLC. This immuno-nutritional score can indicate patients at high risk of postoperative recurrence and death. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  10. [Treating mentally wounded patients within the French armed forces].

    Science.gov (United States)

    Raffray, Pierre; Rio, Anaïck; Lahutte, Bertrand; Boisseaux, Humbert

    2012-12-01

    The French army has put in place a doctrine aimed at treating mentally wounded soldiers. A real treatment pathway comprising different specialised medical staff, places and time frames supports the soldier from the theatre of operations to France.

  11. Receipt of maintenance therapy is most predictive of survival in older acute lymphoblastic leukemia patients treated with intensive induction chemotherapy regimens.

    Science.gov (United States)

    Landsburg, Daniel J; Stadtmauer, Edward; Loren, Alison; Goldstein, Steven; Frey, Noelle; Nasta, Sunita D; Porter, David L; Tsai, Donald E; Perl, Alexander E; Hexner, Elizabeth O; Luger, Selina

    2013-08-01

    While the prognosis for older adults diagnosed with acute lymphoblastic leukemia (ALL) is frequently poor, long-term survival can be achieved in patients treated with curative intent. We reviewed the outcomes of 37 patients age ≥60 treated at our institution with either DVP- or hyperCVAD-based chemotherapy regimens from 2003-2011. In this patient population, a complete response rate of 92%, relapse rate of 56% and median overall survival of 18.1 months was experienced. Univariate analysis revealed that receipt of maintenance therapy vs. no maintenance therapy was associated with a statistically-significant impact on overall survival (p = 0.001, HR 0.15 for death), while disease-related characteristics including high-risk white blood cell count at diagnosis and Philadelphia chromosome status as well as treatment-related factors including chemotherapy regimen or completion of intensive therapy were not. Many patients were unable to initiate or remain on maintenance therapy due to toxicities including infections and cytopenias. Our analysis reveals the benefit of prolonged therapy in the treatment of older adults with ALL as well as the high incidence of treatment-related toxicity experienced by these patients.

  12. CPAP Treats Muscle Cramps in Patients with Obstructive Sleep Apnea

    OpenAIRE

    Westwood, Andrew J.; Spector, Andrew R.; Auerbach, Sanford H.

    2014-01-01

    We describe a case series of 4 patients with varying degrees of obstructive sleep apnea who incidentally had a history of nocturnal leg cramps. None of the patients had periodic limb movements during the study and denied symptoms consistent with restless legs syndrome. In 3 of the 4 patients, nocturnal leg cramps resolved with CPAP treatment for OSA, while the fourth patient noted near-resolution of cramping after starting CPAP. In patients presenting with muscle cramps, obstructive sleep apn...

  13. Personality Disorders in Substance Abusers: A Comparison of Patients Treated in a Prison Unit and Patients Treated in Inpatient Treatment

    Science.gov (United States)

    Stefansson, Ragnar; Hesse, Morten

    2008-01-01

    A large body of literature has shown a high prevalence of personality disorders in substance abusers. We compared a sample of substance abusers treated in a prison setting with substance abusers treated in a non-prison inpatient setting rated with the Millon Clinical Multiaxial Inventory-III. Base-rate scores indicated a prevalence of 95% of…

  14. Using artificial femoral head replacement treated of elderly intertrochanteric fracture--Analysis of curative effect of 103 cases%人工股骨头置换术治疗高龄股骨粗隆间骨折--附103例疗效分析

    Institute of Scientific and Technical Information of China (English)

    钟群华; 王大伟; 陈烨; 苑井宽

    2014-01-01

    目的:分析高龄(>75岁)股骨粗隆间骨折患者采用人工股骨头置换术的疗效。方法:对2004.1~2013.10我院103例高龄股骨粗隆间骨折患者采用人工股骨头假体置换治疗。其中女性67例,男性36例,最大年龄102岁,最小年龄75岁,平均83岁。结果:术中、术后死亡2例,余患者均得到随访,随访时间1~9年(平均3.5年),参照Harris法评分[1]优65例,良26例,可6例,差4例。疗效优良率达88.34%。所有随访患者无发生脱位,经复查X片,假体、髋臼完好无松动93例,髋臼磨损5例,假体周围骨折2例,假体松动1例。结论:证实人工股骨头置换术治疗高龄股骨粗隆间骨折具有减少患者卧床时间,早日下地负重功能锻炼,减少术后并发症等优点。%Objective: to the curative effect of using artificial femoral head replacement treated of the age (>75 years) intertrochanteric fracture patients. Methods: For the elderly which over 75-years-old of intertrochanteric fractures 103 patients were treated with artificial femoral head replacement from January 2004 to October 2013.In the 103 patients which have 67 women, 36 men, the ages between 75 years and 102 years, average 83 years old. Results: Intraoperative and postoperative had death 2 cases, others patients all follow-up, follow-up time of 101 cases are 1 year to 9 years, which averages 3.5 years. Under Harris score [1], 65 cases had excellence, 26 good, 6 mediate, 4 bad, the excellence rate was 88.34%; All the follow-up of patients were no dislocation. Reviewing X-ray films, 93 cases artificial femoral head and acetabulum are good and no loose;5 cases had acetabulum attrition rate;2 cases had prosthesis around fracture;5 cases had prosthesis loose. Conclusion:Application of artificial femoral head replacement in the treatment of elderly intertrochanteric femoral fractures, have shorten patients stay in bed time, early do functional exercise, reduce

  15. Curative observation of acupuncture com-bined with herbal penetration therapy for treating knee osteoarthritis%针灸配合中药外敷治疗膝关节骨性关节炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    高娴

    2016-01-01

    AIM: To investigate the clinical effect of acupunc⁃ture combined with herbal penetration therapy for treating knee osteoarthritis. METHODS: A total of 160 patients with knee osteoarthritis admitted into 92676 Army Hospital from November 2013 to March 2015 were randomly divided into observation group (n=80) and control group(n=80). The observation group was treated by acupuncture and herbal penetration therapy, while the control group was treated by conventional western medicine therapy. The effects of two groups after one course of treatment ( 4 weeks) were compared. RESULTS:The total effective rate of observation group was 78%, and that of the control group was 65%. The observation group was significantly higher than that of the control group, and the difference was statistically significant ( P<0.05 ) . CONCLUSION: Acupuncture can improve blood circulation and relieve the pain, and herbal penetration therapy can effectively promote blood circulation to remove blood stasis and nourish arthritic joints. The combination of acupuncture and herbal penetration therapy for treating knee osteoarthritis was direct, effective and little side⁃effects.%目的:探讨针灸配合中药外敷治疗膝关节骨性关节炎的临床效果.方法:选取92676部队医院2013-11/2015-03收治的160例膝关节骨性关节炎患者,按照就诊序号随机抽样分为观察组( n=80)与对照组( n=80).观察组采用针灸配合中药外敷治疗,对照组采用西医常规对症治疗,两组分别治疗4周(1疗程)后对比疗效.结果:观察组总有效率(78%)明显高于对照组(65%),差异具有统计学意义(P<0.05).结论:针灸能够通经活血、解除疼痛,中药敷贴能够有效活血化瘀,滋补患病关节,两种方法配合治疗膝关节骨性关节炎具有作用直接、疗效确切、不良反应少等优点.

  16. The clinical curative effect observation of Chinese medicine therapy combined with stellate ganglion block in treating cervical vertigo%中医疗法结合星状神经节阻滞治疗颈性眩晕94例疗效观察

    Institute of Scientific and Technical Information of China (English)

    楚福明; 刘亮

    2013-01-01

    目的 探讨中医疗法结合星状神经节阻滞(SGB)治疗颈性眩晕的疗效.方法 将94例颈性眩晕病人随机分为两组,治疗组47倒,采用中医综合治疗及星状神经节阻滞治疗;对照组47例,采用中医综合治疗.治疗结束观察两组疗效.结果 治疗组治疗结束及半年后有效率分别为93.62%和82.98%,对照组有效率分别为82.98%和65.96%,治疗组治愈率分别是48.94%和42.55%,对照组治愈率分别是38.30%和29.79%,两组比较,差异有统计学意义(P<0.05).结论 应用中医中药结合交感神经节阻滞治疗可快速缓解患者眩晕症状,同时能达到病情持续康复.%Objective To explore the curative effect of TCM therapy combined with stellate ganglion block in treating cervical vertigo.Methods 94cervical vertigo sufferers were divided into experimental group and control group 47 for each,experimental group was given TCM therapy combined with stellate ganglion block,while the control group takes TCM therapy only.The clinical curative effect at the end of the treatment were observed.Results At the end of the treatment,the effective ratio of the experimental group was 93.62%,and the control group was82.98% ;the curative ratio of the experimental group was 48.94%,the control group was 38.30%.Six months later,the effective ratio were 82.98% and 65.96%.The curative ratio of the experimental group was 42.55%,the control group was 29.79%.It was significant different between the two groups.Conclusion TCM therapy combined with stellate ganglion block in treating cervical vertigo can fast relieve the symptoms of vertigo,and achieve continual rehabilitation condition.

  17. Curating the innate immunity interactome

    Science.gov (United States)

    2010-01-01

    Background The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks. Systems biology approaches promise to shed new light on the regulation of innate immunity through the analysis and modelling of these networks. A key initial step in this process is the contextual cataloguing of the components of this system and the molecular interactions that comprise these networks. InnateDB (http://www.innatedb.com) is a molecular interaction and pathway database developed to facilitate systems-level analyses of innate immunity. Results Here, we describe the InnateDB curation project, which is manually annotating the human and mouse innate immunity interactome in rich contextual detail, and present our novel curation software system, which has been developed to ensure interactions are curated in a highly accurate and data-standards compliant manner. To date, over 13,000 interactions (protein, DNA and RNA) have been curated from the biomedical literature. Here, we present data, illustrating how InnateDB curation of the innate immunity interactome has greatly enhanced network and pathway annotation available for systems-level analysis and discuss the challenges that face such curation efforts. Significantly, we provide several lines of evidence that analysis of the innate immunity interactome has the potential to identify novel signalling, transcriptional and post-transcriptional regulators of innate immunity. Additionally, these analyses also provide insight into the cross-talk between innate immunity pathways and other biological processes, such as adaptive immunity, cancer and diabetes, and intriguingly, suggests links to other pathways, which as yet, have not been implicated in the innate immune response. Conclusions In summary, curation of the InnateDB interactome provides a wealth of information to enable systems-level analysis of innate immunity. PMID:20727158

  18. Advanced Age is Not a Contraindication for Treatment With Curative Intent in Esophageal Cancer.

    Science.gov (United States)

    Voncken, Francine E M; van der Kaaij, Rosa T; Sikorska, Karolina; van Werkhoven, Erik; van Dieren, Jolanda M; Grootscholten, Cecile; Snaebjornsson, Petur; van Sandick, Johanna W; Aleman, Berthe M P

    2017-07-31

    The objective of this study is to compare long-term outcomes between younger and older (70 y and above) esophageal cancer patients treated with curative intent. Overall survival (OS), disease-free survival (DFS), and locoregional recurrence-free interval were compared between older (70 y and above) and younger (below 70 y) esophageal cancer patients treated between 1998 and 2013. Treatment consisted of neoadjuvant chemoradiotherapy with surgery or definitive chemoradiotherapy: 36 to 50.4 Gy in 18 to 28 fractions combined with 5-fluorouracil/cisplatin or carboplatin/paclitaxel. The study comprised 253 patients, of whom 76 were 70 years and older. Median age was 64 years (range, 41 to 83). Most patients had stage II-IIIA disease (83%). Planned treatment was neoadjuvant chemoradiotherapy with surgery for 169 patients (41 patients aged 70 y and older) and definitive chemoradiotherapy for 84 patients (31 patients aged 70 y and older). The compliance to radiotherapy was 92%, with no difference between older and younger patients. In 33 patients (13 patients aged 70 y and older) planned surgery was not performed. Median follow-up was 4.9 years. Three-year OS was 42%. The multivariable analysis showed no statistical difference in OS or in DFS comparing older and younger patients: OS (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.61-1.28), DFS (HR, 0.87; 95% CI, 0.60-1.25). Elderly showed a longer locoregional recurrence-free interval; HR, 0.53 (95% CI, 0.30-0.92; P=0.02) and a higher pathologic complete response rate (50% vs. 25%; P=0.02). Long-term outcomes of older esophageal cancer patients (70 y and above) selected for treatment with neoadjuvant chemoradiotherapy followed by surgery or definitive chemoradiotherapy were comparable with the outcomes of their younger counterparts. Advanced age alone should not be a contraindication for potentially curative chemoradiotherapy-based treatment in esophageal cancer patients.

  19. Variables Affecting Canalith Repositioning Maneuver (CRM Trend for Treating Patients with Benign Paroxysmal Positional Vertigo (BPPV

    Directory of Open Access Journals (Sweden)

    E. Entezari

    2006-07-01

    Full Text Available Background: The purpose of this study was to identify variables affecting outcome in patients with benign paroxysmal positional vertigo (BPPV treated with canalith repositioning maneuver (CRM. Methods: This interventional study was conducted on 58 patients (14 males, 44 females, mean age 48.12+13.22 referred to the Vertigo Rehabilitation Clinic of the Rehabilitation School of Tehran University of Medical Sciences from 2002 to 2004. All patients were treated with CRM. According to the treatment efficacy the patients were allocated in three groups: completely treated, partially treated, and not treated. The effect of factors including age, sex, etiology, duration of BPPV, unilateral or bilateral disease, number of maneuvers, and number of sessions on outcome in patients was evaluated. Results: Forty-nine patients (84.5% were completely cured. Age, sex, etiology, and duration did not significantly affect the treatment outcome. Unilateral BPPV can be treated significantly better than bilateral BPPV. Forty-seven patients who were completely treated needed 1 session and thirty-seven of them required 2 maneuvers. Conclusion: CRM is significantly effective for BPPV treatment. Treating unilateral BPPV is expected to be easier. As most of the patients will be cured by 1 or 2 maneuvers or in 1 session, patients who required more sessions or more maneuvers may not be completely treated.

  20. Observation of curative effect of Bushenjianpi decoction on promoting ovulation in patients with polycystic ovary syndrome%补肾健脾汤用于多囊卵巢综合征促排卵疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨慧; 张尉

    2013-01-01

    目的 观察补肾健脾汤用于肾亏脾虚型多囊卵巢综合征促排卵的临床疗效.方法 将60例脾肾亏虚型多囊卵巢综合征患者随机分为2组,治疗组30例于月经第5天口服补肾健脾汤水煎剂,1剂/d,连服至排卵日;对照组30例于月经第5天开始口服克罗米芬50mg/d,连服5d.B超监测卵泡生长情况,当卵泡直径≥18mm时,肌肉注射HCG 10000IU诱发排卵.观察HCG日优势卵泡数、最大卵泡平均直径、子宫内膜厚度及排卵率、妊娠率,同时观察患者腰酸腿软、头晕耳鸣、神疲肢倦、纳少便溏等肾亏脾虚的症状改善情况.结果 治疗后治疗组临床症状改善情况明显优于对照组(P均<0.05).治疗组HCG日优势卵泡数、HCG日子宫内膜厚度、妊娠率均优于对照组(P均<0.05).结论 补肾健脾汤治疗肾亏脾虚型多囊卵巢综合征所致不孕促排卵疗效优于西药克罗米芬,且可以明显改善患者临床症状,提高生活质量,值得临床推广应用.%Objective It is to observe the clinical curative effect of Bushenjianpi decoction on promoting ovulation for deficiency of spleen and kidney type polycystic ovary syndrome. Methods 60 patients with deficiency of spleen and kidney type polycystic ovary syndrome were randomly divided into 2 groups. The patients in treatment group( 30 cases ) were treated with Bushenjianpi decoction one dose a day by oral administration from the 5th day menstruation to oviposit day. The control group ( 30 cases ) were treated with clomiphene citrate 50 mg/d on the 5th day menstruation, continued for 5 days. Follicular growth was detected by B - mode ultrasound, ovulation was induced by intramuscular injection of HCG 10 000 units when the follicular diameter & 18 mm. The quantity of advantage follicles, average maximum follicular diameter, endometrial thickness and o-vulation rate, pregnancy rate were observed on the HCG days. At the same time the improvements of the spleen and kidney

  1. 疏血通联合异丙嗪、三磷酸腺苷、维生素B6治疗眩晕症的临床疗效观察%Curative effect observation of Shuxuetong with promethazine, ATP, vitamin B6 treat vertigo

    Institute of Scientific and Technical Information of China (English)

    刘磊

    2014-01-01

    Objective To discuss the clinical efficacy of Shuxuetong with promethazine, ATP, vitamin B6 in the treatment of vertigo, provide effective theoretical basis for the treatment of rapid treatment. Methods 60 patients with vertigo were randomly divided into treatment group and control group. Treatment group was treated with Shuxuetong, promethazine,ATP, vitamin B6; the control group was given the treatment of promethazine, 654-2. Comparison of curative effect of two groups of patients after 3h. Results Effective 28 cases in the treatment group after treatment 3h, significantly better than the 20 cases in the control group, P<0.01. Conclusion Shuxuetong combination with promethazine, adenosine triphosphate, vitamin B6 treatment of emergency vertigo is a safe and effective and fast treatment, worthy of clinical application.%目的:探讨疏血通联合异丙嗪、三磷酸腺苷、维生素B6治疗眩晕症的临床疗效,为急诊快速救治提供有效理论依据。方法将60例眩晕症患者随机分为治疗组和对照组。治疗组给予疏血通、异丙嗪、三磷酸腺苷、维生素B6治疗;对照组给予异丙嗪、654-2治疗。对比两组患者在3h后的疗效。结果治疗组在治疗3h后有效26例,明显好于对照组17例,P<0.05。结论疏血通联用异丙嗪、三磷酸腺苷、维生素B6治疗眩晕症是一种安全有效而又快速的治疗手段,值得临床推广应用。

  2. Curative efficacy observation and nursing on infantile diarrhea treated with Traditional Chinese Medicine "diarrhea paste" external applied on acupoint Shenjue%中药“腹泻贴”外敷神厥穴治疗小儿泄泻的疗效观察及护理

    Institute of Scientific and Technical Information of China (English)

    李新聪

    2014-01-01

    目的:中药腹泻贴外敷神厥穴治疗小儿泄泻的临床疗效,探讨护理人员在治疗中的作用。方法:将100例泄泻患儿随机分成治疗组50例、对照组50例。对照组给予常规西医治疗,治疗组在常规西医治疗的基础上根据辨证分型加中药腹泻贴外敷神厥穴治疗。结果:治疗组总有效率96%,明显高于对照组80%,差异有统计学意义(P<0.01)。结论:中药腹泻贴治疗泄泻患儿疗效显著,可减轻患儿的痛苦,依从性好。%Objective:To explore the clinical curative effect on infantile diarrhea treated with Traditional Chinese Medicine"diarrhea paste"external applied on acupoint Shenjue and the role of nursing staff on the treatment. Methods:100 cases of children with diarrhea were randomly divided into a treatment group of 50 cases and a control group of 50 cases. The patients in the control group were given conventional western medicine treatment, while the patients in the treatment group were given the therapy of Traditional Chinese Medicine“diarrhea paste”external applied on acupoint Shenjue on the basis of conventional western medicine treatment according to syndrome differentiation type diarrhea. Results:The total effectiveness of the treatment group was 96%, obviously higher than that of control group 80%, and the difference was statistically significant (P<0.01). Conclusion:Chinese medicine for children with diarrhea has obvious therapeutic effect which can reduce the pain but with good adherence.

  3. The curative effect in skeletal Class III children patients with the facemask appliance%面具式前方牵引矫治器治疗儿童骨性III类错牙合的疗效分析

    Institute of Scientific and Technical Information of China (English)

    赵清娟; 杨燕方; 吴秋瑾; 刘海霞

    2015-01-01

    Objective To evaluate the curative effect in skeletal Class Ⅲ children patients following the facemask appliance. Methods The 19 patients treated with facemask appliance in the second hospital affiliated Xinjiang Medical University during 2010 to 2013 were selected. The lateral cephalometric radiographs and models of SNA,SNB,ANB,SND,Wits value,U1- L1,FMA,SN- MP,SN- PP, U1- SN,IMPA,NLA,ULP,LLP,upper facial height,lower facial height,the models of maxillary dental arch width (forepart,midpiece,posterior part) were compared before treatment and after treatment. Results The 19 patients had received for six months, and SNA,ANB,Wits value,U1- L1,FMA,SN- MP,SN- PP, upper facial height,lower facial height,IMPA,NLA,LLP,the modelsof maxillary dental posterior arch width,the length of the mandibular were significantly different before and after treatment ( P0.05). Conclusion Protraction with facemask appliance can stimulate growth of maxillary bone of the patients, and makes the maxillary and mandible rotate clockwise, but it makes little control of mandible growth.%目的:评价面具式前方牵引矫治器治疗儿童骨性III类错牙合临床效果。方法:选取2010~2013年就诊于新疆医科大学第二附属医院利用面具式矫治器进行矫治的19例(男12例,女7例)儿童骨性III类错牙合患者的矫治前与矫治结束时头颅侧位片和模型,并测量SNA、SNB、ANB、SND、Wits、U1-L1、FMA、SN-MP、SN-PP、U1-SN、IMPA、NLA、ULP、LLP、上面高、下面高、上颌模型牙弓宽度(前段、中段、后段),比较其矫治前后的变化。结果:所有患者都进行了前方牵引6个月,SNA、ANB、Wits值、U1-L1、FMA、SN-MP、SN-PP、上面高、下面高、IMPA、NLA、LLP、上颌模型后段、下颌长度,比较其治疗前后,差异有统计学意义,SND、U1-SN、SNB、ULP、上颌模型前段、上颌模型中段比较其矫治前后无统计学意义。结论:使用前方牵引矫治器

  4. Weight bias among professionals treating eating disorders: attitudes about treatment and perceived patient outcomes.

    Science.gov (United States)

    Puhl, Rebecca M; Latner, Janet D; King, Kelly M; Luedicke, Joerg

    2014-01-01

    This study aimed to assess weight bias among professionals who specialize in treating eating disorders and identify to what extent their weight biases are associated with attitudes about treating obese patients. Participants were 329 professionals treating eating disorders, recruited through professional organizations that specialize in eating disorders. Participants completed anonymous, online self-report questionnaires, assessing their explicit weight bias, perceived causes of obesity, attitudes toward treating obese patients, perceptions of treatment compliance and success of obese patients, and perceptions of weight bias among other practitioners. Negative weight stereotypes were present among some professionals treating eating disorders. Although professionals felt confident (289; 88%) and prepared (276; 84%) to provide treatment to obese patients, the majority (184; 56%) had observed other professionals in their field making negative comments about obese patients, 42% (138) believed that practitioners who treat eating disorders often have negative stereotypes about obese patients, 35% (115) indicated that practitioners feel uncomfortable caring for obese patients, and 29% (95) reported that their colleagues have negative attitudes toward obese patients. Compared to professionals with less weight bias, professionals with stronger weight bias were more likely to attribute obesity to behavioral causes, expressed more negative attitudes and frustrations about treating obese patients, and perceived poorer treatment outcomes for these patients. Similar to other health disciplines, professionals treating eating disorders are not immune to weight bias. This has important implications for provision of clinical treatment with obese individuals and efforts to reduce weight bias in the eating disorders field. Copyright © 2013 Wiley Periodicals, Inc.

  5. Compare the curative effect of two kinds of therapy to treat athlete’s foot%两种疗法治疗足癣的疗效比较

    Institute of Scientific and Technical Information of China (English)

    薛宛玲

    2015-01-01

    objective to explore the combined oral and external use of antifungal drugs and use of compound preparation for external use clinical curative effect for the treatment of athlete’s foot.Methods the tubby naphthalene Finn oral joint compound ketone health zun external use, and results were compared with pure compound ketone health zun external use, to evaluate the effect of the combination therapy.Results the experimental group and control group 4 weeks after drug withdrawal efficient were 96.80% and 72.83% respectively, fungal clearance were 95.83% and 59.72%respectively, the difference was statistically significant (P<0.05).Conclusion combined treatment can shorten the treatment course, improve the cure rate, fungal clearance than single drug curative effect is satisfied.%目的:探讨联合口服和外用抗真菌药物与单用复方制剂外用治疗足癣的临床疗效。方法采用特比萘芬口服联合复方酮康唑外用,并与单纯复方酮康唑外用作对照,评价该联合疗法的疗效。结果试验组与对照组停药4周后有效率分别为96.80%和72.83%,真菌清除率分别为95.83%和59.72%,差异有统计学意义(P<0.05)。结论联合治疗可以缩短疗程,提高治愈率,真菌清除率较单一用药疗效满意。

  6. Clinical curative effect analysis and predictors of prognosis in patients with temporal lobe epilepsy after anterior temporal lobectomy:results after five years

    Institute of Scientific and Technical Information of China (English)

    Sun Zhenxing; Yuan Dan; Sun Yaxing; Zhang Jianguo; Zuo Huancong; Zhang Kai

    2014-01-01

    Background Anterior temporal lobectomy (ATL) is the most common surgical treatment for temporal lobe epilepsy (TLE),although long-term prognosis is often less favorable than short-term outcomes.This study aimed to examine the outcomes of patients with TLE 5 years after undergoing ATL,and to seek possible predictors of prognosis.Methods We examined the clinical records of 121 patients with TLE who underwent ATL in our institution between January 2005 and December 2008.The Engel seizure classification was used to divide patients into "seizure free" and "non-seizure free" groups.Univariate and multivariate Logistic regression analyses were used to identify potential prognostic indicators,including history,clinical features of seizures,and magnetic resonance imaging (MRI) and videoelectroencephalography (EEG) findings.Results The majority of patients were seizure free during the follow-up period:71.9% 1 year after surgery; 71.6% after 2 years; 75.8% after 3 years; 78.8% after 4 years after surgery and 68.8% after 5 years.There were significant differences between seizure-free and non-seizure-free groups in terms of preoperative seizure duration,history of febrile seizures,type of seizure,and MRI and video-EEG findings (P <0.05),but not in terms of sex,age at seizure onset,age at surgery,side of surgery,auras,family history of seizure,or history of traumatic brain injury,perinatal anoxia or intracranial infection history (P >0.05).Multivariate Logistic regression analysis showed that a preoperative seizure duration <10 years,a history of febrile seizures,simple complex partial seizures,positive MRI findings,hippocampal sclerosis and unilateral localized video-EEG spikes predicted better outcome (P <0.05).Conclusions ATL appears to be an effective means of treating TLE.Patients undergoing ATL for TLE require careful and comprehensive assessment to ensure optimal outcomes and to allow patients to make informed decisions about their treatment.

  7. Optimize patient health by treating literacy and language barriers.

    Science.gov (United States)

    Dreger, Vicki; Tremback, Tom

    2002-02-01

    More than 90 million Americans have limited literacy skills. Almost two million US residents cannot speak English, and millions more speak it poorly. The stigma of illiteracy or the inability to speak a country's predominant language keep patients from disclosing their limitations. Recognizing these facts is an important first step in improving health education for this vulnerable population. By adapting teaching techniques to patients' special needs, nurses can ensure that patients understand their health problems and plan of care. Statistics dramatically demonstrate the high cost of neglecting these needs. Patients who do not understand their plan of care do not comply with instructions and, therefore, suffer unnecessary complications. Health care providers who can communicate with their patients through multilingual, low literacy patient education materials and with the use of qualified interpreters markedly improve the quality of care for their patients and the resulting outcomes.

  8. An observation of the characteristics of allergens and curative effect for patients with chronic intractable eczema in Zhaoqing%肇庆地区慢性顽固性湿疹患者的过敏原特征及疗效观察

    Institute of Scientific and Technical Information of China (English)

    帅春海; 陈洁华

    2014-01-01

    Objective To explore the relations between various allergens in nature and the morbidity of chronic eczema so as to provide guidance for prevention and treatment for the patients, and carry out a statistical assessment towards the curative effect after the treatment. Methods Allergens of 274 patients with chronic eczema were tested via BIotray866 Auto Blot Processor produced in Shenzhen Rayto Life and Analytical Sciences Co.,Ltd. The curative effect was observed after desensitization treatment. 125 patients with chronic eczema were selected as a control group, and received regular treatment for eczema instead of the desensitization treatment. Results Positive rate of allergens in 274 patients with chronic eczema reached up to 79.56%(218 patients); among the allergens for patients with positive results, the positive rate of dermatophagoides farina ranked the first with 46 patients, and other allergens were seafood, cow's milk and sheep's milk. Some patients were allergic to multiple allergens. The patients received desensitization treatment and kept away from the allergens, and only 28 patients(12.84%) relapsed in a 1-year follow-up, showing a significantly curative effect compared with 72 relapsed patients(57.6%) in the control group. Conclusion For patients with chronic intractable eczema, causes of disease should be actively traced during diagnosis and treatment, and related allergens should be avoided during their daily life. In such way, diseases can be effectively treated and prevented, and relapse rate can be significantly reduced.%目的:探讨自然界各种过敏原与慢性湿疹患者发病的关系,为患者的预防和治疗提供指导依据,并对治疗后的效果进行统计学评价。方法采用深圳雷杜BIotray866全自动过敏原分析仪器对274例慢性湿疹患者进行过敏原的检测,在脱敏治疗后观察疗效,同时设立125例对照湿疹患者,不进行脱敏治疗只进行常规湿疹治疗。结果274例慢性

  9. 龙血竭胶囊加逍遥丸治疗乳腺增生症临床观察%Clinical curative effect observation of mammary gland hyperplasia treated by dragon’s blood capsule and the ease pill

    Institute of Scientific and Technical Information of China (English)

    陈波; 刘晓蛟; 周红

    2015-01-01

    目的:观察龙竭胶囊加逍遥丸治疗乳腺增生症的疗效。方法:选择270例门诊女性乳腺增生症患者,随机分为A 组、B 组、C 组,每组各90例。A 组:方法为口服逍遥丸,每次8粒,每日2次;同时口服龙血竭胶囊1.8 g,每日2次;B 组:口服三苯氧胺片,每次10 mg,每日2次;C 组:口服逍遥丸,每次8粒,每日2次;一个疗程为15 d,服用需要3个疗程,开始于月经来潮后第5天,结束于下次月经来潮。结果:治疗有效率比较,A 组有效率为86%(77/90),B 组有效率为92%(83/90),C组有效率42%(38/90),A 组、B 组明显高于 C 组,有统计学意义(P <0.05);而 A 组与 B 组相比,无统计学意义(P >0.05)。不良反应结果显示 A 组占3%(5例),B 组占38%(35例),C 组占2%(2例),A 与 B 组比较,差异有统计学意义(P <0.05);A 与 C 组比较,差异无统计学意义(P >0.05)。血清性激素结果显示,各组均可降低 E 2及 PRL 的水平,同时升高 P、T 的含量, A 组和 B 组作用与 C 组比较有统计学差异(P <0.05)。结论:逍遥丸加龙血竭胶囊治疗乳腺增生症较单独使用逍遥丸方法有效,与三苯氧胺相比,具有副作用小的优势,因此值得基层医院推广。%Objective:To observe the curative effect of dragon's blood capsule and the ease pill against mammary gland hyper-plasia.Methods:270 female patients with mammary gland hyperplasia proved by clinic were randomly divided into 3 groups:group A, B and group C,90 cases in each.Group A:taking the ease pill 2 times each day,8 pills each time;taking dragon's blood capsule 2 times each day,1 .8 g each time.Group B:taking tamoxifen pills,2 times each day,10 mg each time.Group C:taking the ease pill 2 times each day,8 pills each time.All drugs were taken from the 5th day of the menstruation period,till the next

  10. The relationship between environmental parameters of saline and underground karst - patients with different diseases in the course of speleotherapy - anthropogenic effect - keeping intact the underground environment and curative properties.

    Science.gov (United States)

    Simionca, Iu.; Hoteteu, M.; Chonka, Ia.; Slavik, P.; Kubas, J.; Grudnicki, N.

    2009-04-01

    One of the non-pharmacological therapy in patients with bronchial asthma (AB) and other BPOC is speleotherapy (ST), recognized as a complementary therapy. The curative effect of ST depends on geophysic structure of massive salt or karst, of mine or cave cavities, lack of noxes and toxic gas, also on the lack of the plant and microbial allergen, on the microclimatic parameters, sanitary and other parameters of the underground environment, on the mechanism of curative factors in these specific environments, on the medical particularities and disease specific speleotherapeutic methodology. An essential role they have environmental studies of underground cavities that own speleotherapeutic properties and use in medical and balneoclimatic tourism purposes. Among these studies are: - Air temperature, soil and salt layer; - Atmospheric pressure and the difference from the outside; - Relative humidity of the air underground; - Velocity of air currents; - Concentration of positive and negative air ions; - Particle size and concentration of saline aerosol; - Concentration of microorganisms, including pathogens, conditioning-pathogenic and saprophytic in air, soil saline and salt walls in rooms designed for speleotherapy; - Concentration of allergens; - Concentration of oxygen and carbon dioxide, the presence and concentration of ozone, the gaseous pollutants (NO2, SO2, hydrocarbons and derivatives of ozone); - Radioactivity (type, value), the presence and concentration of radon. Taking into consideration the possibility of anthropogenic effect on the underground salt or karst environment produced by patients with chronic inflammatory diseases, respiratory or skin allergic diseases is needed to assess the underground environmental sanitary parameters in various main locations (the entrance in the underground, the artificial or natural air flow; the sanatory area " - the location where patients or tourists are keeped for a period of 1-3 or more hours, bathroom) and the

  11. Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors

    Science.gov (United States)

    2015-03-18

    Adult Rhabdomyosarcoma; Adult Synovial Sarcoma; Childhood Hepatoblastoma; Childhood Synovial Sarcoma; Previously Treated Childhood Rhabdomyosarcoma; Recurrent Adrenocortical Carcinoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Liver Cancer; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive; Neuroectodermal Tumor; Recurrent Neuroblastoma; Recurrent Osteosarcoma; Recurrent Retinoblastoma; Recurrent Wilms Tumor and Other Childhood Kidney Tumors

  12. 蛙式扳法治疗骶髂关节源性下腰痛的临床疗效观察%Clinical Observation on Curative Effect of Wa-shi Pulling on Treating Sacroiliac Joint Pain

    Institute of Scientific and Technical Information of China (English)

    诸波; 范炳华; 王鹏; 应晓明; 徐泉珍; 郭少卿

    2012-01-01

    Objective: To observe the clinical efficacy of the Wa - shi pulling on treating sacroiliac joint pain and to explore the mechanism of the Wa - shi pulling. Methods: 60 patients diagnosed as sacroiliac joint pain were collected and treated with the four operative steps of the Wa - shi pulling to observe the clinical efficacy. Results: The treatment time ranged from 1 to 7 (average 4 times). According to evaluation standard of sacroiliac joint pain, the results were cured in 50 cases,improvement in 9 cases,inefficacy in 1 case. Conclusion:The Wa - shi pulling had many advantages such as targeted and quick effect and high rate of success in treatment of sacroiliac joint pathological changes due to low back pain.%目的:通过观察蛙式四步扳法治疗骶髂关节源性下腰痛的临床疗效,探讨蛙式四步扳法的作用机制.方法:临床收集被确诊为骶髂关节源性下腰痛患者60例,采用自体牵引,极度屈髋屈膝,蛙式扳法和后伸扳法四步操作,观察其疗效.结果:治疗次数1~7次,平均治疗4.0次.疗效评价治愈50例,好转9例,未愈1例.结论:蛙式四步扳法治疗骶髂关节源性下腰痛针对性强,见效快,成功率高.

  13. Treating approaches of neurotic disorders in patients with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Erkin Toirov

    2010-09-01

    Full Text Available During investigation of neurotic conditions in 168 patients with rheumatoid arthritis in 65.6% patients it was determined neurotic disorders (ND of different severity. Astheno-vegetative disorders were diagnosed in most cases (61.3%. Treatment of ND was carried out depending on the type and degree of its significance. In case of mild ND degree the complex treatment included sing general stimulating medications, physiotherapy and treatable physical training. Treatment for moderate ND degree used sedative medication (novopassit, sedavit, glisin, pion tincture, and the one for severe disease degree used antidepressants and tranquilizers. The treatment duration depended on the type of therapy (10-21 days.The treatment course provided significant reduction of ND symptoms in 66 patients (54.1% and full reduction of symptoms - in 44 patients (36.1%. In 12 patients (9.8% we did not determine any reductions of clinical symptoms of ND. Psychotherapy course provided positive outcomes in 62.3% of patients, satisfactory - in 26.2% of patients, and unsatisfactory - in 11.5% of patients. In the control group (46 patients without ND these results were taken accordingly in 52.2%, 37.0% and 10.8% of patients.

  14. Influenza vaccination coverage in patients treated with chemotherapy : current clinical practice

    NARCIS (Netherlands)

    Wumkes, M. L.; van der Velden, A. M. T.; van der Velden, A. W. G.; Stouthard, J. M. L.; Nijziel, M. R.; Westerman, M.; Beeker, A.; Meerveld-Eggink, A.; Rijkers, G. T.; Biesma, D. H.

    2013-01-01

    Background: Influenza virus vaccination is recommended for patients treated with chemotherapy. Little is known about vaccination coverage in these patients. Methods: Vaccination coverage in the Netherlands was analysed by questionnaires completed by general practitioners, within a catchment area of

  15. Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin.

    Science.gov (United States)

    Biswas, J S; Patel, A; Otter, J A; Wade, P; Newsholme, W; van Kleef, E; Goldenberg, S D

    2015-07-01

    Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI). This study investigated whether fidaxomicin for treatment of all patients with CDI reduced C. difficile environmental contamination. Surfaces in the rooms of 66 hospitalized patients treated with metronidazole and/or vancomycin and 68 hospitalized patients treated with fidaxomicin were sampled. Patients treated with fidaxomicin were less likely to contaminate their environment (25/68, 36.8%) than patients treated with metronidazole and/or vancomycin (38/66 57.6%) (P = 0.02). Treatment with fidaxomicin was associated with reduced environmental contamination with C. difficile.

  16. Workflow Tools for Digital Curation

    Directory of Open Access Journals (Sweden)

    Andrew James Weidner

    2013-04-01

    Full Text Available Maintaining usable and sustainable digital collections requires a complex set of actions that address the many challenges at various stages of the digital object lifecycle. Digital curation activities enhance access and retrieval, maintain quality, add value, and facilitate use and re-use over time. Digital resource lifecycle management is becoming an increasingly important topic as digital curators actively explore software tools that perform metadata curation and file management tasks. Accordingly, the University of North Texas (UNT Libraries develop tools and workflows that streamline production and quality assurance activities. This article demonstrates two open source software tools, AutoHotkey and Selenium IDE, which the UNT Digital Libraries Division has adopted for use during the pre-ingest and post-ingest stages of the digital resource lifecycle.

  17. [Personality and emesis in the patient treated with antineoplastic chemotherapy].

    Science.gov (United States)

    Llorca, G; Martín, T; Derecho, J; Gómez, M J

    1991-01-01

    A sample of twenty cancer patients following chemotherapy realize MMPI questionnaire, and another one for valuation of emetic and anticipatory phenomena in relation to said therapy. The authors came to the conclusion that 36.8% of the sample had anticipatory nausea and vomiting, 63.6% anticipatory dysphoria, and 66% emetic incidents after chemotherapy. The conclusion, through comparison of personality variables, is that all patients showed neuroticism and depression scales increased, in relation to healthy population. Depression variable increased especially in patients that didn't present anticipatory nausea and vomiting. Likewise, patients with anticipatory symptoms or emetic incidents after chemotherapy present an increased social introversion variable.

  18. Immunoreactivity examination of patients with testicular tumours treated with radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Stefanits, K.; Kuhn, E.; Csere, T.

    1985-02-01

    Results of the immunoreactivity study of 72 patients receiving radiotherapy are presented. Tuberculin and DNCB (2,4 dinitrochlorobenzol) reactivity tests were performed before, during and 3 years after the radiation therapy and at the time when metastases appeared. The number of positive reactions decreased slightly in both tuberculin and DNCB groups, though not significantly. Metastatic patients showed a significant decrease of reactivity against DNCB as compared with the results obtained before the treatment. In 5,6% of patients herpes zoster was registered. No other infections occured. It was found that immunosuppression caused by the radiation treatment does not influence the later fate of patients with testicular tumours. 41 refs.

  19. Atrial fibrillation in fracture patients treated with oral bisphosphonates

    DEFF Research Database (Denmark)

    Abrahamsen, B; Eiken, P; Brixen, K

    2009-01-01

    -2005). SUBJECTS: Fracture patients beginning bisphosphonates (n = 15 795) were matched with unexposed fracture patients of the same age, sex and fracture type (n = 31 590). RESULTS: Incidence rates of AF were 16.5/1000 person years in untreated fracture patients and 20.6/1000 person years in bisphosphonate users...... to adherence. There was no increased risk of ischaemic stroke and an increased risk of myocardial infarction was not significant after adjustment for comorbidity. CONCLUSIONS: The increased occurrence of AF in fracture patients who are users of oral bisphosphonates should be attributed to targeting...

  20. 多囊卵巢综合征性不孕症中西医结合治疗效果观察%Curative effect observation on chinese and western medicine treating polycystic ovary syndrome of infertility

    Institute of Scientific and Technical Information of China (English)

    冯发雨

    2016-01-01

    目的:分析行中西医结合疗法的多囊卵巢综合征性不孕症患者的临床效果。方法调查对象从我院2011年5月至2014年7月接收多囊卵巢综合征性不孕症患者中抽选,将100例分成不同处理组,即:西医组(西医疗法,克罗米芬)、中西医组(中西医疗法,克罗米芬加中药自拟汤剂),治疗后对结果进行评定。结果中西医组患者治疗后疾病缓解率为92.0%,和西医组缓解率的72.0%相比高,两者之间存在差异(P<0.05)。结论临床针对多囊卵巢综合征性不孕症患者行中西医结合疗法作用突出,可促进卵泡发育,增强临床效果,值得推广应用。%Objective to analyze clinical effect of chinese and western medicine treating polycystic ovary syndrome of infertility. Methods choose survey objects from infertility patients with polycystic ovary syndrome treated in our hospital from May 2011 to July 2014, 100 cases were divided into different treatment groups, namely: Western medicine group (Western medicine therapy, clomiphene), traditional Chinese medicine and Western medicine group (combination of traditional Chinese and Western medicine, clomiphene and self-made traditional Chinese medicine decoction), evaluate treatment results.Results remission rate was 92% of traditional Chinese medicine and Western medicine group after treatment, and that was 72% of western medicine group, there was difference between two groups (P<0.05).Conclusion traditional Chinese medicine and Western medicine therapy has outstanding effect polycystic ovary syndrome infertility patients, which can promote follicular development and enhance clinical effect. It is worthy of promotion and application.

  1. 探讨缬沙坦和阿托伐他汀治疗高血压病合并持续性房颤的疗效%Explore the Curative Effect about Valsartan and Atorvastatin to Treat Hypertention with Persistent Atrial Fibrillation

    Institute of Scientific and Technical Information of China (English)

    潘冰冰

    2014-01-01

    目的:探讨缬沙坦和阿托伐他汀治疗高血压病合并持续性房颤的疗效。方法选取来我院的高血压病合并持续性房颤患者40例,随机分为两组,每组20例,为实验组和对照组。对照组给予常规的抗凝治疗,服用阿托伐他汀同时服用硝苯地平缓释片;实验组则在对照组的基础上服用缬沙坦治疗。观察两组患者的血压变化、hs-CRP、LAD以及LVMI。结果两组患者治疗前血压无明显差异(P>0.05),治疗后两组患者血压觉得到明显改善,但实验组治疗效果与对照组相比,治疗效果更加良好(P<0.05)。两组患者治疗前hs-CRP、LAD以及LVMI均无显著差异(P>0.05),治疗后,实验组治疗效果明显优于对照组(P<0.05)。结论缬沙坦和阿托伐他汀联合治疗高血压病合并持续性房颤效果明显较之单独使用一种药物效果好,值得临床使用及进一步探讨。%Objective To explore the curative effect about valsartan and atorvastatin to treat hypertention with persistent atrial ifbrillation. Methods Choose 40 patients with hypertention and persistent atrial ifbrillation who came to our hospital last year, randomly dividing into two groups, the experimental group and the control group. The control group was treated with atorvastatin and nifedipine zyban, following with anticoagulation therapy. The experimental group with the control groups the same, besides the valsartan taken. Then, observe the changes of two groups of patients with blood pressure, hs-CRP, LAD and LVMI. Results There is no difference in blood pressure between the two groups of patients before treatment, but the treatment effect of the experimental group is better than the control posttreatment. And there is also no difference in hs-CRP, LAD and LVMI between the two groups of patients before treatment, but the treatment effect of the experimental group is also better than the control posttreatment. Conclusion

  2. Observation of Curative Effect of Self Righting Rise White Leucopenia after Chemotherapy to Treat Malignant Tumor%自拟扶正升白方治疗恶性肿瘤化疗后白细胞减少的疗效观察

    Institute of Scientific and Technical Information of China (English)

    郭晓琴

    2015-01-01

    目的:观察自拟扶正升白方治疗恶性肿瘤化疗后白细胞减少的疗效。方法选取160例恶性肿瘤化疗后白细胞减少的患者,随机分为观察和对照组各80例,观察组予自拟扶正升白方,对照组予鲨肝醇、利血生治疗,连用三周,比较两组患者外周血象白细胞计数变化。结果据卫生部《药物临床研究指导原则》中制定的升高白细胞疗效标准,观察组:显效48例,有效23例,无效9例,总有效率88.75%,对照组:显效27例,有效29例,无效24例,总有效率70.00%,两组比较有显著性差异(P<0.05),Karnofsky 功能状态评分标准(KPS)评分≥70分:观察组61例,对照组35例,两组比较有极显著差异(P<0.01)。结论自拟扶正升白方可在一定程度上治疗化疗引起的白细胞下降,改善患者生存质量。%Objective To observe the curative effect of self-made fuzhengshengbai party leucopenia after chemotherapy to treat malignant tumor. Methods 160 cases of patients with leukopenia after chemotherapy in patients with malignant tumor, were randomly divided into observation and control group with 80 cases in each group, the observation group were treated by Fuzheng Shengbai decoction, the control group was given batyl alcohol, Leucogen treatment for three weeks, compared two groups of patients with peripheral blood white cel count changes. Results According to the Ministry of health "drug clinical research guiding principle" made in increasing leukocyte effect standard, the observation group: excel ent in 48 cases, effective 23 cases, invalid 9 cases, the total efficiency of 88.75%, control group: excel ent in 27 cases, effective 29 cases, invalid 24 cases, the total efficiency of 70%, compared with two groups there was a significant difference (P<0.05), Karnofsky score standard functional status (KPS) score more than 70 points: 61 cases in observation group, 35 cases in the control group, the two

  3. Pulmonary artery dissection in a patient with Eisenmenger syndrome treated with heart and lung transplantation

    DEFF Research Database (Denmark)

    Tønder, Niels; Køber, Lars; Hassager, Christian

    2004-01-01

    We report the case of a patient with known Eisenmenger syndrome due to congenital ventricular septal defect, who developed pulmonary artery dissection. The patient was successfully treated with heart and lung transplantation.......We report the case of a patient with known Eisenmenger syndrome due to congenital ventricular septal defect, who developed pulmonary artery dissection. The patient was successfully treated with heart and lung transplantation....

  4. Curative effect of point massage in patients with chronic insomnia%穴位按摩治疗慢性失眠患者的疗效观察

    Institute of Scientific and Technical Information of China (English)

    李小敏; 陈慧; 赵连旭; 周月玲

    2011-01-01

    Objective To observe the influence of point massage at head and body points on sleep structure in chronic insomnia patients.Methods 45 patients were treated by point massage on the same main points including Anmian,Sishencong,Shenmen,Sanyinjiao temple for two to five minutes,once every day,abidingly for 20 to 30 days(averaged 24 ± 5 days).The change of patients' sleep structure before and after treatment was tested by poly-somnography analytical system.Self-control statistical methods were used to analyze the data.Results Before treatment,sleep structure of 45 cases were all incomplete; some patients missed S3 or S4.Being treated with point massage for 30 days,all patients got some improvement of falt and broken sleep structure.Sleep Monitoring showed that Point massage shortened latency period of sleep,lengthened the time of slow-wave sleep(S + S4 period),shorten the time of somnolence(S1 + S2 period),and relatively lengthened the time of NREMS and REMS (P< 0.05).Conclusion Point massage can repair the sleep structure,remold its continuity to a certain extent,and lengthen the time of slow-wave sleep,which is the main mechanism of improving sleep quality by acupuncture.%目的 观察穴位按摩对慢性失眠患者睡眠结构的影响及其治疗效果.方法 45例患者均采用穴位按摩法治疗.穴位取安眠、四神聪、神门、三阴交及太阳穴为主穴,根据中医辩证施治原则,再选择其他辅助穴位按摩.每个穴位按压2~5分钟,按摩天数20 ~ 30天(平均24±5天).治疗前、后使用多道睡眠描记监测分析系统检测患者睡眠结构的变化.结果 治疗前,45例患者的睡眠结构均不完整,部分患者S3或S4缺失.治疗30天后,所有患者的睡眠结构得到一定程度的修复和改善;睡眠监测分析显示,患者的睡眠潜伏期缩短,慢波睡眠时间(S+S4)增加,REMS的释放延长,浅睡眠时间(S1+S2期)缩短,NREMS和REMS相对延长(P<0.05).结论 穴位按摩疗法能够修复

  5. Treating Infertility

    Science.gov (United States)

    ... Education & Events Advocacy For Patients About ACOG Treating Infertility Home For Patients Search FAQs Treating Infertility Page ... Treating Infertility FAQ137, March 2015 PDF Format Treating Infertility Gynecologic Problems What is infertility? What treatment options ...

  6. Curative treatment of oesophageal carcinoma: current options and future developments

    Directory of Open Access Journals (Sweden)

    Bruns Christiane

    2011-05-01

    Full Text Available Abstract Since the 1980s major advances in surgery, radiotherapy and chemotherapy have established multimodal approaches as curative treatment options for oesophageal cancer. In addition the introduction of functional imaging modalities such as PET-CT created new opportunities for a more adequate patient selection and therapy response assessment. The majority of oesophageal carcinomas are represented by two histologies: squamous cell carcinoma and adenocarcinoma. In recent years an epidemiological shift towards the latter was observed. From a surgical point of view, adenocarcinomas, which are usually located in the distal third of the oesophagus, may be treated with a transhiatal resection, whereas squamous cell carcinomas, which are typically found in the middle and the upper third, require a transthoracic approach. Since overall survival after surgery alone is poor, multimodality approaches have been developed. At least for patients with locally advanced tumors, surgery alone can no longer be advocated as routine treatment. Nowadays, scientific interest is focused on tumor response to induction radiochemotherapy. A neoadjuvant approach includes the early and accurate assessment of clinical response, optimally performed by repeated PET-CT imaging and endoscopic ultrasound, which may permit early adaption of the therapeutic concept. Patients with SCC that show clinical response by PET CT are considered to have a better prognosis, regardless of whether surgery will be performed or not. In non-responding patients salvage surgery improves survival, especially if complete resection is achieved.

  7. Impairments and disabilities in patients treated by exercise therapists.

    NARCIS (Netherlands)

    Zuijderduin, W.M.; Dekker, J.

    1994-01-01

    This study provides a description of the patient population of exercise therapists (Cesar and Mensendieck). The study focuses on impairments and disabilities as diagnosed by the exercise therapists. Data were recorded by 48 Cesar therapists on 1020 patients, and by 52 Mensendieck therapists on 1088

  8. Clinical observation and therapeutic evaluation of intravenous pump of recombinant human endostatin combined with TP regimen in treating patients with advanced ovarian cancer

    Institute of Scientific and Technical Information of China (English)

    Chi Zhang; Wen-Ying Deng; Ning Li; Su-Xia Luo

    2015-01-01

    Objectives: To observe the curative effects and adverse reactions of recombinant human (rh)-endostatin injection combined with a TP regimen for treating patients with advanced ovarian cancer.Methods: Fifty-four patients with pathologically confirmed ovarian cancer were randomly divided into a combined treatment (intravenous pump of rh-endostatin + TP regimen) group and a control (single chemotherapy) group, twenty-seven patients in each group.All patients were given a conventional CT examination.The level of vascular endothelial growth factor (VEGF), the size of tumor before treatment, after 2 cycles and after 4 cycles of treatment were determined for the comparison of curative effects and adverse reactions.Results: The effective rate was 37.0% (10/27) and disease control rate was 63.0% (17/27) in the combined treatment group after 2 cycles of treatment.The effective rate was 25.9% (7/27) and disease control rate was 63.0% (17/27) in the control group.The comparison between these two groups showed no significant differences (P > 0.05).The effective rate was 63.0% (17/27) and disease control rate was 92.6% (25/27) in the combined treatment group after 4 cycles of treatment.The effective rate was 29.6% (8/27) and disease control rate was 63.0% (17/27) in the control group.The effective rate and disease control rate between these two groups after 4 cycles of treatment showed significant differences (P < 0.05).The incidences of cardiovascular toxicity, myelosuppression, sore muscles and joints, alopecia and gastrointestinal reaction was not significantly different between two groups (P > 0.05).Conclusion: The pump delivery of rh-endostatin can down-regulate the expression of VEGF in ovarian cancer and has the better curative effect and slighter adverse reactions.Copyright 2015, Chinese Medical Association Production.Production and hosting by Elsevier B.V.on behalf of KeAi Communications Co., Ltd.This is an open access article under the CC BY

  9. Sexual function in lithium-treated manic-depressive patients

    DEFF Research Database (Denmark)

    Kristensen, Ellids; Jørgensen, Per

    1987-01-01

      Sexual function in 24 patients with major affective disorders who were given prophylactic lithium treatment was compared with that of a control group of surgical outpatients with no known psychiatric disease. Changes in sexual function during lithium treatment were also recorded retrospectively...... in sexual function during lithium treatment were reported by one-fourth of the patients. Of these, four reported a positive influence of the treatment and five a negative influence. Statistically, significantly more patients than controls were dissatisfied with their present sex life........ Sexual dysfunctions were described by about one-fourth of both female patients and controls. About one-third of the male patients and controls reported sexual dysfunctions. We cannot exclude tha lithium in combination with other psychotropic drugs may increase the frequency of sexual dysfunction. Changes...

  10. Diabetic patients treated with dialysis: complications and quality of life

    DEFF Research Database (Denmark)

    Sørensen, V R; Mathiesen, E R; Watt, T

    2007-01-01

    AIMS/HYPOTHESIS: The aim of this study was to describe the prevalence of complications, health-related quality of life (HRQOL) and the influence of beliefs about control over health in diabetic dialysis patients. METHODS: Of 53 eligible diabetic patients on chronic dialysis during January 2004...... in our clinic, 38 (76%) completed a kidney-specific (Kidney Disease Quality of Life) and a generic (SF-36) questionnaire and were characterised in terms of cardiovascular diseases and diabetic complications. Matched groups of non-diabetic dialysis patients (n = 40) and diabetic patients with a long...... population (47 +/- 19). The diabetic dialysis patients had similar levels of kidney-specific quality of life and mental health compared with the control groups. Reduced physical health was predicted by the presence of end-stage renal disease, diabetes and short time spent in education. Among the diabetic...

  11. Target lesion revascularisation in patients treated with a sirolimus-eluting or paclitaxel-eluting stent

    DEFF Research Database (Denmark)

    Maeng, Michael; Okkels Jensen, Lisette; Rasmussen, Klaus;

    2007-01-01

    OBJECTIVE: To identify risk factors for clinical-driven target lesion revascularisation (TLR) in patients treated with sirolimus-eluting (Cypher) or paclitaxel-eluting (Taxus) stents in a real-world scenario. DESIGN: From 1 January 2003 to 18 May 2005, all patients treated with a Cypher or Taxus ...

  12. Cytotoxicity and T-B Cell Crosstalk in Belatacept-Treated Kidney Transplant Patients

    NARCIS (Netherlands)

    G.N. de Graav (Gretchen)

    2017-01-01

    markdownabstractIn this dissertation, we aimed to learn more about the immune mechanisms involved in alloreactivity in patients treated with belatacept or tacrolimus after kidney transplantation. In particular, we sought to explain the higher acute rejection rate in belatacept-treated patients by st

  13. Obilježja bolesnika liječenih plazmaferezom [Characteristics of patients treated with plasmapheresis

    OpenAIRE

    Brunetta Gavranić, Bruna

    2015-01-01

    Frequent use of therapeutic plasmapheresis and advances in medicine and technology generated significant changes in indications, complications, method and epidemiological characteristics of patients treated with this procedure. Nevertheless many questions still remain open. Database of the National Referral Centre for therapeutic plasmapheresis and apheresis was retrospectively analyzed for changes in indications, complications, method and epidemiological characteristics of patients treate...

  14. Radiation pneumonitis in non‑small‑cell lung cancer patients treated ...

    African Journals Online (AJOL)

    Conclusions: We found that poor PS and V5–V15 were the risk factors associated with grade ≥3 RP in NSCLC patients treated with HT. Thus, for NSCLC patients treated with HT, the volume of total lung with low-dose ..... Adenocarcinoma.

  15. Data curation + process curation=data integration + science.

    Science.gov (United States)

    Goble, Carole; Stevens, Robert; Hull, Duncan; Wolstencroft, Katy; Lopez, Rodrigo

    2008-11-01

    In bioinformatics, we are familiar with the idea of curated data as a prerequisite for data integration. We neglect, often to our cost, the curation and cataloguing of the processes that we use to integrate and analyse our data. Programmatic access to services, for data and processes, means that compositions of services can be made that represent the in silico experiments or processes that bioinformaticians perform. Data integration through workflows depends on being able to know what services exist and where to find those services. The large number of services and the operations they perform, their arbitrary naming and lack of documentation, however, mean that they can be difficult to use. The workflows themselves are composite processes that could be pooled and reused but only if they too can be found and understood. Thus appropriate curation, including semantic mark-up, would enable processes to be found, maintained and consequently used more easily. This broader view on semantic annotation is vital for full data integration that is necessary for the modern scientific analyses in biology. This article will brief the community on the current state of the art and the current challenges for process curation, both within and without the Life Sciences.

  16. Curative treatment for central nervous system medulloepithelioma despite residual disease after resection. Report of two cases treated according to the GPHO protocol HIT 2000 and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Klaus [Leipzig Univ. (Germany). Dept. of Radiotherapy and Radiooncology; Zwiener, Isabella [University Medical Center Univ. Mainz (Germany). Inst. for Medical Biostatistics, Epidemiology and Informatics; Welker, Helmut [Katharinenhospital, Stuttgart (Germany). Dept. of Radiotherapy and Radiooncology; Maass, Eberhard [Klinikum Stuttgart - Olgahospital (DE). Pediatrics 5 (Oncology, Hematology, Immunology); Bongartz, Rudolf [Koeln Univ. (Germany). Dept. of Radiotherapy and Radiooncology; Berthold, Frank [Koeln Univ. (Germany). Dept. of Pediatric Oncology; Pietsch, Torsten [Bonn Univ. Medical Center (Germany). Dept. of Neuropathology; Warmuth-Metz, Monika [Wuerzburg Univ. (Germany). Dept. of Neuroradiology; Bueren, Andre von; Rutkowski, Stefan [University Medical Center Hamburg-Eppendorf, Hamburg (Germany). Dept. of Pediatric Hematology and Oncology

    2011-11-15

    Medulloepithelioma of the central nervous system (CNS) is an uncommon primitive neuroectodermal tumor (PNET) usually occurring in early childhood. It is characterized by highly malignant behavior with a propensity for progression, recurrence, and dissemination despite intensive therapy. Due to its rarity, the optimal management is still unknown. However, gross total resection (GTR) has been considered crucial to achieve cure. In this article, the authors report on 2 cases of CNS medulloepithelioma in which long-term survival (more than 6 years) could be achieved despite evidence of, or suspected postoperative residual disease with an otherwise dismal prognosis. The patients were treated according to different strata of the protocol for primitive neuroectodermal tumors (PNET) of the German-Austrian multicenter trial of the German Society for Pediatric Oncology and Hematology (GPOH) for childhood brain tumors (HIT 2000). Treatment included postoperative hyperfractionated radiotherapy of the craniospinal axis followed by a boost to the tumor site in combination with chemotherapy. A review of the 2 reported and 37 previously published cases confirmed GTR and older age as positive prognostic factors. (orig.)

  17. Curative treatment for central nervous system medulloepithelioma despite residual disease after resection. Report of two cases treated according to the GPHO Protocol HIT 2000 and review of the literature.

    Science.gov (United States)

    Müller, Klaus; Zwiener, Isabella; Welker, Helmut; Maass, Eberhard; Bongartz, Rudolf; Berthold, Frank; Pietsch, Torsten; Warmuth-Metz, Monika; von Bueren, André; Rutkowski, Stefan

    2011-11-01

    Medulloepithelioma of the central nervous system (CNS) is an uncommon primitive neuroectodermal tumor (PNET) usually occurring in early childhood. It is characterized by highly malignant behavior with a propensity for progression, recurrence, and dissemination despite intensive therapy. Due to its rarity, the optimal management is still unknown. However, gross total resection (GTR) has been considered crucial to achieve cure. In this article, the authors report on 2 cases of CNS medulloepithelioma in which long-term survival (more than 6 years) could be achieved despite evidence of, or suspected postoperative residual disease with an otherwise dismal prognosis.The patients were treated according to different strata of the protocol for primitive neuroectodermal tumors (PNET) of the German-Austrian multicenter trial of the German Society for Pediatric Oncology and Hematology (GPOH) for childhood brain tumors (HIT 2000). Treatment included postoperative hyperfractionated radiotherapy of the craniospinal axis followed by a boost to the tumor site in combination with chemotherapy. A review of the 2 reported and 37 previously published cases confirmed GTR and older age as positive prognostic factors.

  18. 紫杉醇联合奈达铂在老年食管癌的疗效分析%Analysis Curative Effect of Taxol Combine With Eugene Nida in Senium Patients With Esophagus Cancer

    Institute of Scientific and Technical Information of China (English)

    陈文玲

    2016-01-01

    目的:探究紫杉醇联合奈达铂治疗老年食管癌的临床疗效。方法根据治疗方案不同将66例老年食管癌患者分为A组(36例)和B组(30例),分别给予紫杉醇联合奈达铂和紫杉醇联合顺铂,比较两组近期疗效、毒副反应及1、2年内生存率。结果 A组毒副反应发生率低于B组,1、2年生存率均高于B组,差异有统计学意义(P<0.05)。结论对于老年晚期食管癌,多采用紫杉醇联合奈达铂治疗,近期疗效和耐受性均较高,可提高患者生存率。%Objective Analysis curative effect of taxol combine with eugene nida in senium patients with esophagus cancer.Methods 66 cases of elderly patients with esophageal cancer, which were divided into group A (36 cases) and group B (30 cases), were given nida, paclitaxel plus cisplatin and paclitaxel combined cisplatin, compared two groups in the near future curative effect, adverse reaction and 1, 2 year survival rate.Results The incidence of adverse reaction of group A is lower than group B, 1, 2 year survival rates were higher than group B, the more significant difference (P<0.05).Conclusion The elderly advanced esophageal cancer, with paclitaxel plus platinum chemotherapy treatment pattern, the recent high efficacy and tolerability, can improve patients survival rate.

  19. 两种网片悬吊术治疗女性压力性尿失禁的疗效比较%Comparison of curative effect between two mesh suspensions in treating female stress urinary incontinence

    Institute of Scientific and Technical Information of China (English)

    洪岭; 孙静; 滕晓明; 李昆明; 李怀芳; 樊伯珍; 童晓文

    2010-01-01

    目的 评估两种网片悬吊术治疗女性压力性尿失禁的疗效及安全性.方法 将75例女性压力性尿失禁(SUI)患者分成2组,A组(35例)采用童氏前路悬吊术治疗,B组(40例)行改良TVT-O术治疗,分析2组手术疗效、安全性及并发症等.结果 2组术式在手术时间[(20.13±4.96)min vs(16.46±7.65)min]、术中出血[(39.86±5.48)ml vs(37.23±8.25)ml]、损伤(0 vs 0)、近期尿潴留(1/35 vs 2/40)、治愈率(94.3% vs 92.5%)等方面差异均无统计学意义(P>0.05),但A组手术费用低于B组[(980.74±212.45)元 vs (2879.06±467.13)元],差异有统计学意义(P<0.05).结论 两种术式对SUI的治疗效果相似,改良TVT-O手术难度较大,适合在大型医院内进行推广;童氏前路悬吊术不经盆腔,完全在直视下进行,操作简单、安全、经济,也可在基层医院内进行推广,还可以作为TVT、SPARC、ⅣS、MONARC、TOT、TVT-O等术式失败后的一种补救手术措施.%Objective To evaluate the curative effect difference between Tong's anterior mesh suspension and modified tension-free vaginal tape-obturator (TVT-O). Methods 75 SUI cases were random divided into two groups: Group A (35 cases) were accepted Tong's anterior mesh suspension and group B (40cases) were accepted modified tension-free vaginal tape- obturator. Curative effects, operation safety,and complications and so on, were recorded and compared. Results There had no statistical differences between these two groups on operation time, bleeding lose, operation injury, immediate postoperative urinary retention andcure rates, but the operation expense of group A was cheaper than group B [ (980. 74 ±212.45)yuan vs (2879.06 ±467. 13)yuan , P <0.05). Conclusion The curative effect between two methods were similar. It's a little complicated and fit to be popularized in large hospital to modified tensionfree vaginal tape-obturator. Tong's anterior mesh suspension was performed under completely direct vision,not through

  20. Color vision loss in patients treated with chloroquine

    Directory of Open Access Journals (Sweden)

    Ventura Dora F.

    2003-01-01

    Full Text Available Patients that make use of chloroquine or hydroxychloroquine, drugs which are frequently administered for treatment of rheumatoid arthritis, lupus erithromatosus or malaria, may suffer alterations in color vision and in contrast sensitivity. The present work evaluates the visual function of these patients in a joint study of the University of São Paulo (USP, in São Paulo, and of the Federal University of Pará (UFPA, in Belém. Thirty two chloroquine user patients without alterations in the eye fundus exam were evaluated in São Paulo (n=10; aged 38 to 71 years; mean=55,8 years and in Belém (n=22; aged 20 to 67; mean=40 years. The prescribed accumulated chloroquine dose was 45 to 430 g (mean=213 g; sd = 152 g for the São Paulo group, and 36 to 540 g (mean=174 g; sd=183 g for the Belém group. Tests were performed monocularly with corrected eye refractive state. Color discrimination was evaluated using the Cambridge Colour Test (CCT: the color discrimination threshold was measured first in the protan, deutan and tritan axes and, in succession, three MacAdam's ellipses were determined. The patient's color vision was also evaluated with color arrangement tests: the Farnsworth-Munsell 100 Hue (FM100, the Farnsworth-Munsell D15, and the Lanthony Desaturated (D15d tests. We also measured the contrast sensitivity for black-and-white sine wave grating of twenty two patients. The results were compared with controls without ophthalmologic or neuro-ophthalmologic pathologies. Twenty four patients presented acquired dyschromatopsia. There were cases of selective loss (11 patients and of diffuse loss (13 patients. Although losses were present in the FM100 there was no correlation between the FM100 error score and the ellipse area measured by the CCT. Moreover, three patients that scored normal in the FM100, failed to reach normal threshold in the CCT. The Lanthony test was less sensitive than the other two tests, since it failed to indicate loss in about

  1. American brain tumor patients treated with BNCT in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Laramore, G.E.; Griffin, B.R.; Spence, A.

    1995-11-01

    The purpose of this work is to establish and maintain a database for patients from the United States who have received BNCT in Japan for malignant gliomas of the brain. This database will serve as a resource for the DOE to aid in decisions relating to BNCT research in the United States, as well as assisting the design and implementation of clinical trials of BNCT for brain cancer patients in this country. The database will also serve as an information resource for patients with brain tumors and their families who are considering this form of therapy.

  2. [A new method for treating patients with chronic prostatitis].

    Science.gov (United States)

    Boĭko, M I

    1995-01-01

    A new preparation is reported for treatment of chronic inflammation of the prostate, which substantially lowers rates of patients' complaints and depresses the secretion leucocyte reaction. Prostatilen was shown to be capable of normalization of immunity status of the chronic prostatitis patients thus lowering the microbial index of the cultured prostate secretion microorganisms. The following new nonantibacterial strategy of treatment of chronic prostatitis patients is proposed: prostatilen given as a single agent or in combination with immunomodulators and physiotherapeutic methods. Antibacterial therapy is to be instituted on a short-term basis only during the period of exacerbation of the inflammatory process.

  3. Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab

    NARCIS (Netherlands)

    Weide, Benjamin; Martens, Alexander; Hassel, Jessica C.; Berking, Carola; Postow, Michael A.; Bisschop, Kees; Simeone, Ester; Mangana, Johanna; Schilling, Bastian; Di Giacomo, Anna Maria; Brenner, Nicole; Kaehler, Katharina; Heinzerling, Lucie; Gutzmer, Ralf; Bender, Armin; Gebhardt, Christoffer; Romano, Emanuela; Meier, Friedegund; Martus, Peter; Maio, Michele; Blank, Christian; Schadendorf, Dirk; Dummer, Reinhard; Ascierto, Paolo A.; Hospers, Geke; Garbe, Claus; Wolchok, Jedd D.

    2016-01-01

    Purpose: Biomarkers for outcome after immune-checkpoint blockade are strongly needed as these may influence individual treatment selection or sequence. We aimed to identify baseline factors associated with overall survival (OS) after pembrolizumab treatment in melanoma patients. Experimental Design:

  4. Treating Patients with High-Risk Smoldering Myeloma

    Science.gov (United States)

    In this phase III clinical trial, patients with smoldering myeloma classified as high risk for progression will be randomly assigned to undergo standard observation or six 4-week courses of treatment with the drug lenalidomide.

  5. Risk factors in patients surgically treated for peptic ulcer perforation

    DEFF Research Database (Denmark)

    Møller, Morten Hylander; Shah, Kamran; Bendix, Jørgen;

    2009-01-01

    OBJECTIVE: The overall mortality for patients undergoing surgery for perforated peptic ulcer has increased despite improvements in perioperative monitoring and treatment. The objective of this study was to identify and describe perioperative risk factors in order to identify ways of optimizing...... the treatment and to improve the outcome of patients with perforated peptic ulcer. MATERIAL AND METHODS: Three hundred and ninety-eight patients undergoing emergency surgery in four university hospitals in Denmark were included in the study. Information regarding the pre-, intra- and postoperative phases were...... insufficiency upon admission and insufficient postoperative nutrition have been added to the list of independent risk factors for death within 30 days of surgery in patients with peptic ulcer perforation. Finding that shock upon admission, reduced albumin blood levels upon admission, renal insufficiency upon...

  6. Valproic Acid Induced Hyperammonemia in a Long Time Treated Patient

    Directory of Open Access Journals (Sweden)

    Rohit Aiyer

    2016-01-01

    Full Text Available We report a case of a patient who had been on long time valproic acid for treatment of bipolar affective disorder. While being an inpatient, serology ammonia level testing revealed a very high ammonia level despite being asymptomatic. Dual therapy of carnitine and lactulose was provided to the patient for treatment of the hyperammonemia. It should also be noted that, during this treatment, valproic acid was not stopped. Consequently, this case illustrates that patients can present asymptomatically despite very high ammonia levels and hyperammonemia can occur in chronic valproic acid despite not increasing the dose of the medication and psychiatrists do not need to discontinue valproic acid in the presence of elevated levels of ammonia if the patient shows no signs of encephalopathy or delirium.

  7. Evaluation of Oxidative Status in Patients Treated with Electroconvulsive Therapy

    Science.gov (United States)

    Şenyurt, Mahmut; Aybek, Hulya; Herken, Hasan; Kaptanoglu, Bunyamin; Korkmaz, Ali

    2017-01-01

    Objective Electroconvulsive therapy (ECT) is used in the treatment of many psychiatric diseases and this therapy may be effective on antioxidant defence system. In this study, we aimed to evaluate the effects of ECT on oxidative stress. Methods Fourteen major depression, 11 schizophrenia and 8 bipolar affective disorder patients diagnosed and received ECT treatment, and 37 healthy volunteers enrolled in the study. ECT was applied to all patients. Before ECT, after the first and last ECTs, serum samples were obtained. Serum total antioxidant status (TAS), total oxidant status (TOS), and calculated oxidative stress index (OSI) were measured in patients before and after ECTs. Results TOS values before ECT were higher in major depression (p=0.005) and schizophrenia (p=0.001) groups compared to the control group. TAS values were lower in major depression (p=0.0001), schizophrenia (p=0.004), bipolar affective disorder (p=0.004) groups compared to the controls. Also OSI values were higher in major depression (p=0.0001), schizophrenia (p=0.001), bipolar affective disorder (p=0.009) groups compared to healthy group. After the last ECT, TOS values were significantly lower compared to TOS values before ECT in major depression (p=0.004) and schizophrenia patients (p=0.004). TAS values after the first ECT were higher compared to values before ECT in major depression patients (p=0.004). After last ECT, OSI values were significantly lower compared to before ECT in schizophrenia patients (p=0.006). Conclusion As a result, it can be said that ECT did not increase oxidative stress. However, further studies with more patients are needed. PMID:28138109

  8. Treating depression in HIV-positive patients affects adherence

    Directory of Open Access Journals (Sweden)

    M Y H Moosa

    2012-09-01

    Full Text Available Aim. To determine changes in adherence to antiretroviral therapy (ART in HIV-positive patients with depression, following treatment with an antidepressant or psychotherapy. Methods. The study was prospective, randomised and controlled. Consenting volunteers aged ≥18 years and stable on ART for ≥6 months were included in the study. Sociodemographic data were obtained, and a clinical diagnostic evaluation and the Hamilton Depression rating scale (HAMD were performed on all subjects at entry to and at the end of the study. Participants found to be depressed were randomly assigned antidepressant treatment (20 mg citalopram or interpersonal psychotherapy (IPT (5 sessions. Medication was dispensed at each visit and patients were asked to return all unused medication to determine ART adherence. The study was approved by the University of the Witwatersrand. Results. Sixty-two HIV-positive persons receiving ART participated; 30 were not depressed (control group and 32 were depressed (patient group. No significant differences in demographic characteristics existed between the control and patient groups. Mean ART adherence at the start of the study was 99.5% (standard error (SE ±0.46 and 92.1% (SE ±1.69 in the control and patients groups, respectively. Mean ART adherence at the end of the study changed marginally in the control group (99.7%; SE ±0.46 and increased significantly in the patient group (99.5%; SE± 0.13 (p>0.05. The mean ART adherence rate of patients who received pharmacotherapy increased from 92.8% to 99.5%, and of those who received psychotherapy increased from 91.1% to 99.6% (p>0.05. There was no significant association between the increased adherence in the patient group and baseline demographic and clinical characteristics, irrespective of antidepressant therapy or IPT (p>0.05. Conclusion. Successful treatment of depression with an antidepressant or psychotherapy was associated with improved ART adherence, independent of the type

  9. Analysis the curative effects of total knee arthroplasty using in elderly patients with knee osteoarthritis%老年膝关节骨关节炎患者全膝关节置换术后的疗效分析

    Institute of Scientific and Technical Information of China (English)

    马晓军

    2015-01-01

    Objective:Observe the the curative effects of total knee arthroplasty using in elderly patients with knee osteoarthritis .Methods:Selected 56 patients (71 knees)of elderly knee osteoarthritis patients from Janu-ary 2012 to January 2014 in our hospital,all of the patients received total knee replacement surgery,compared the HSS knee scoring postoperative and before treatment,compared the effect.Results:HSS various scores of the pa-tients postoperative were significantly higher than that of preoperative,the differences between groups were statisti-cally significant,P >0.05).Postoperatively,knee joint function of patients was 91.55%,was significantly increased compared with before treatment,P 0.05)。术后,患者的膝关节功能优良率达到了91.55%,较治疗前明显升高(P <0.01)。结论:全膝关节置换术应用于晚期膝关节骨性关节炎老年患者的治疗可以起到很好的效果。可以有效缓解患者的疼痛症状,更快地恢复膝关节功能,值得临床应用。

  10. Early electroretinografic changes in elderly RA patients treated with hydroxychloroquine

    Directory of Open Access Journals (Sweden)

    C. Gelmi

    2011-09-01

    Full Text Available Objective: to evaluate the effectiveness of fundoscopy, electrooculography, electroretinogram and visually evoked potentials in early detection of hydroxychloroquine retinal toxicity in RA patients and to evaluate the influence of patients’ age, drug dosage, concomitant therapy (prednisone and methotrexate and serum creatinine levels in the development of this side effect. Methods: from september to december 1999, we have enrolled 32 RA patients (13 males, 19 females starting hydroxichlorochine treatment. The patients underwent regular ophthalmological examination (fundoscopy, electro-oculography, electro-retinogram and visually evoked potentials every 4 months. Disease activity was evaluated every two months by clinical and routine serological examination. Results: no patients developed retinopathy during 1 year’s follow-up; fundoscopy, electrooculography, and visually evoked potentials did not vary from the baseline. On the other hand, electroretinogram showed early alterations of scotopic and photopic response; moreover a significant statistical correlation between patients’ age (more than 65 years and b1 photopic wave increase (p < 0,05 was observed. No correlation was found between the developement of electro- retinographic alterations and hydroxychloroquine dosage, concomitant therapy and serum creatinine levels Conclusion: our data show the inefficacy of fundoscopy, electrooculography and visually evoked potentials in early detection of hydroxychloroquine retinopathy. On the other hand electroretinogram allows early detection of retinal alterations during hydroxychloroquine treatment, in patients older than 65 years.

  11. Muscle function in rheumatic disease patients treated with corticosteroids.

    Science.gov (United States)

    Rothstein, J M; Delitto, A; Sinacore, D R; Rose, S J

    1983-02-01

    Clinical and experimental data indicate that long-term corticosteroid use leads to atrophy of the type 2 muscle fibers. The purpose of this study was to characterize and quantify the nature of muscle function in rheumatic disease patients who have been on long-term corticosteroid therapy. Quadriceps function (i.e., peak torque and power) in 19 patients (11 with rheumatoid arthritis, five with systemic lupus erythematosis, and 3 other) and 11 age- and activity-matched normal controls was measured with an isokinetic dynamometer (Cybex II), during four constant velocity movements. Power was significantly lower for the patients at all speeds. At the higher speeds the patients' deficit in power production increased as indicated by a difference in the slopes of power-velocity regression lines. Measures of peak torque could not be consistently used to differentiate the groups. Patients with rheumatic diseases receiving corticosteroids have a decreased ability to generate muscle power. The method described allows for quantification of these deficits in a clinical setting.

  12. The clinical curative effects of prehospital nursing care on patients with heavy craniocerebral injury%重型颅脑损伤患者院前救护效果分析

    Institute of Scientific and Technical Information of China (English)

    周细银; 张梓童; 蒋彩霞; 范学荣

    2013-01-01

    目的 分析探究对重型颅脑损伤患者行院前救护临床疗效.方法 选取本院收治的72例重型颅脑损伤患者,其中50例入院急救前行院前救护作为观察组,22例未行院前救护作为对照组,观察组与对照组入院后均立即进行急救,比较两组患者治疗后疗效以及格拉斯哥昏迷(GCS)值.结果 观察组50例中31例痊愈,占62%,28例好转,占56%,1例死亡,占2%,对照组22例中7例痊愈,占31.82%,9例好转,占40.91%,6例死亡,占27.27%,观察组治疗效果明显高于对照组(P<0.05),15 d后观察组GCS评分明显高于对照组(P<0.05).结论 院前救护可以提高重型颅脑损伤患者入院后的治疗效果,降低并发症发生率,减少患者死亡率,临床效果显著,值得临床推广运用.%Objective To explore the clinical curative effects of prehospital nursing care on patients with heavy craniocerebral injury.Methods Totaled of 72 patients with heavy craniocerebral injury were selected and divided into two groups.Observation group with 50 cases adopted prehospital nursing care,and control group with 22 cases did not adopted prehospital nursing care.Two groups were compared with curative effects and GCS value.Results In the observation group,31 cases of 50 cases healed,28 cases got better,1 case death,the proportion was respectively 62%,56% and 2% ; in the control group,7 cases of 22 cases healed,9 cases got better,6 cases death,the proportion was respectively 31.82%,40.91%,27.27%.The curative effects of observation group was obviously better than that of control group (P < 0.05).GCS score was obviously higher than that of the control group after 15 days (P < 0.05).Conclusions Prehospital care can improve the curative effects of patients with heavy craniocerebral injury,reduce the incidence of complications and reduce mortality of patients.Clinical effects is remarkable,it is worth spreading in clinic.

  13. Cognitive Curations of Collaborative Curricula

    Science.gov (United States)

    Ackerman, Amy S.

    2015-01-01

    Assuming the role of learning curators, 22 graduate students (in-service teachers) addressed authentic problems (challenges) within their respective classrooms by selecting digital tools as part of implementation of interdisciplinary lesson plans. Students focused on formative assessment tools as a means to gather evidence to make improvements in…

  14. Curating the CIA World Factbook

    Directory of Open Access Journals (Sweden)

    Peter Buneman

    2009-12-01

    Full Text Available The CIA World Factbook is a prime example of a curated database – a database that is constructed and maintained with a great deal of human effort in collecting, verifying, and annotating data. Preservation of old versions of the Factbook is important for verification of citations; it is also essential for anyone interested in the history of the data such as demographic change. Although the Factbook has been published, both physically and electronically, only for the past 30 years, we appear in danger of losing this history. This paper investigates the issues involved in capturing the history of an evolving database and its application to the CIA World Factbook. In particular it shows that there is substantial added value to be gained by preserving databases in such a way that questions about the change in data, (longitudinal queries can be readily answered. Within this paper, we describe techniques for recording change in a curated database and we describe novel techniques for querying the change. Using the example of this archived curated database, we discuss the extent to which the accepted practices and terminology of archiving, curation and digital preservation apply to this important class of digital artefacts.

  15. Teacher Training in Curative Education.

    Science.gov (United States)

    Juul, Kristen D.; Maier, Manfred

    1992-01-01

    This article considers the application of the philosophical and educational principles of Rudolf Steiner, called "anthroposophy," to the training of teachers and curative educators in the Waldorf schools. Special emphasis is on the Camphill movement which focuses on therapeutic schools and communities for children with special needs. (DB)

  16. Breast cancer patients treated with chemotherapy reports more unmet supportive care needs in the early treatment phase, than patients treated only with radiotherapy

    DEFF Research Database (Denmark)

    Jensen-Johansen, Mikael Birkelund; Meldgaard, Anette; Henriksen, Jette

    2016-01-01

    Breast Cancer Patients Treated with Chemo-therapy Reports More Unmet Supportive Care Needs in the Early Treatment Phase, than Patients Treated Only with Radio-therapy Jensen-Johansen, Mikael Birkelund, Meldgaard, Anette, Henriksen, Jette, Villadsen, Ingrid VIA University College, Holstebro, Denmark...... treatment period. Eighty-five percent agreed to participate and 100 women filled out the baseline questionnaire. Forty-five women were under treatment with radiation-therapy, forty-nine with chemo-therapy and four women were treated with both radiation- and chemotherapy. Design and methods: As part...... & information-, physical & daily living-, patient care & support-, and sexuality needs. Analysis: The subscales of the SCNS revealed good reliability (Cronbach’s alpha: .79 - .96) and the summated scores were skewed and therefore log-transformed. An independent samples t-test was conducted to compare the need...

  17. Treating malignant glioma in Chinese patients: update on temozolomide

    Directory of Open Access Journals (Sweden)

    Chang L

    2014-02-01

    Full Text Available Liang Chang,1 Jun Su,1 Xiuzhi Jia,2,3 Huan Ren2,3 1Department of Neurosurgery, The Tumor Hospital of Harbin Medical University, 2Department of Immunology, Harbin Medical University, 3Key Lab Infection and Immunity, Heilongjiang Province, Harbin, People's Republic of China Abstract: Malignant glioma, ie, anaplastic astrocytoma and glioblastoma, is the most common type of primary malignant brain tumor in the People's Republic of China, and is particularly aggressive. The median survival of patients with newly diagnosed glioblastoma is only 12–14 months despite advanced therapeutic strategies. Treatment of malignant glioma consists mainly of surgical resection followed by adjuvant radiation and chemotherapy. Temozolomide (TMZ, a second-generation oral alkylating agent, is playing an increasingly important role in the treatment of malignant glioma in Chinese patients. Since the publication of a study by Stupp et al in 2005, which used a protocol of conventional fractionated irradiation with concomitant TMZ followed by standard TMZ for six cycles, many clinical studies in the People's Republic of China have demonstrated that such a treatment strategy has significantly improved efficacy with limited side effects for newly diagnosed glioblastoma after surgery as compared with strategies that do not contain TMZ. However, as a relatively new agent, the history and development of TMZ for malignant glioma is not well documented in Chinese patients. Multicenter, randomized controlled trials including appropriately sized patient populations investigating multiple aspects of TMZ therapy and related combination therapies are warranted in patients with malignant glioma. This review provides an update on the efficacy, mechanism of action, adverse reactions, and clinical role of TMZ in the treatment of malignant glioma in Chinese patients. Keywords: malignant glioma, chemotherapy, temozolomide, efficacy, side effect, People's Republic of China

  18. Patient with intractable delirium successfully treated with electroconvulsive therapy

    DEFF Research Database (Denmark)

    Lindgren, Eske; Hageman, Ida

    2014-01-01

    Delirium is a frequent and serious condition often seen in hospitalized patients, especially the elderly. Treatment of the somatic illness causing the delirium, and antipsychotic medication will usually resolve the condition. Sometimes, however, the condition is refractory towards medical treatment...... and in this situation electroconvulsive therapy (ECT) can be a quick and efficient treatment. In this case report of a 26-year-old man a post-operative intractable delirium persisting for three weeks was efficiently and swiftly relieved by three consecutive ECTs. The patient was discharged without need for further...

  19. Curation of OSIRIS-REx Asteroid Samples

    Science.gov (United States)

    Righter, K.; Nakamura-Messnger, K.; Lauretta, D. S.; Osiris-Rex Curation Working Group

    2013-09-01

    An overview of the mission curation plan will be given, including the main elements of contamination control, sample recovery, sample cleanroom construction, and curation support once the sample is returned to Earth.

  20. Impact of time from diagnosis to initiation of curative-intent chemotherapy on clinical outcomes in patients with classical Hodgkin lymphoma.

    Science.gov (United States)

    Brooks, Edward G; Connors, Joseph M; Sehn, Laurie H; Gascoyne, Randy D; Savage, Kerry J; Shenkier, Tamara N; Klasa, Richard; Gerrie, Alina S; Skinnider, Brian; Slack, Graham W; Villa, Diego

    2016-01-01

    The impact of treatment delays on outcomes in Hodgkin lymphoma (HL) is currently unknown. Time from definitive histologic diagnosis to first ABVD treatment (TDT) was calculated in 810 adults with HL: 365 (45%) TDT ≤4 weeks, 369 (46%) TDT 5-8 weeks, 76 (9%) TDT >8 weeks. The 5-year overall survival (OS) was 92% TDT ≤4 weeks, 92% TDT 5-8 weeks, and 83% TDT >8 weeks (p = 0.007). The 5-year disease-specific survival (DSS) was 93% TDT ≤4 weeks, 95% TDT 5-8 weeks, and 87% TDT >8 weeks (p = 0.094). The 5-year progression-free survival (PFS) was similar between groups (p = 0.139). In the multivariate analysis, TDT >8 weeks was not associated with worse OS, DSS, or PFS. Despite the univariate association between initiation of ABVD >8 weeks and worse OS, these data do not support such cut-off to improve outcomes. Nevertheless, clinicians should make every effort possible to initiate curative-intent chemotherapy as soon as a diagnosis of HL is established.

  1. Treating depression in HIV-positive patients affects adherence

    African Journals Online (AJOL)

    2012-09-02

    19,20-22 maintain CD4 cell counts; prevent clinical ... affecting ART adherence in HIV-positive patients,32-35 ... 99.5%, and of those who received psychotherapy increased .... children (chi2=5.022; p=0.285); past history.

  2. Tryptophan degradation and neopterin levels in treated rheumatoid arthritis patients.

    Science.gov (United States)

    Ozkan, Yesim; Mete, Guray; Sepici-Dincel, Aylin; Sepici, Vesile; Simsek, Bolkan

    2012-01-01

    Increased kynurenine/tryptophan-reflects trytophan degradation-and neopterin levels have been regarded as a biochemical marker of cell-mediated immune response and inflammation. This study was designed to evaluate the usefulness of tryptophan degradation and neopterin levels in active rheumatoid arthritis patients under therapy. In this case-control study, kynurenine and tryptophan levels were determined by HPLC; neopterin and tumor necrosis factor-α levels were measured with ELISA in 32 active rheumatoid arthritis patients and 20 healthy controls. Although mean values of tryptophan, kynurenine, ratio of kynurenine to tryptophan, neopterin, and tumor necrosis factor-α levels did not show statistically significant differences between patient and control groups, neopterin levels correlated positively with kynurenine (r = 0.582, p < 0.02), kynurenine/tryptophan (r = 0.486, p < 0.05), erythrocyte sedimentation rate (r = 0.472, p < 0.05) and RF (r = 0.478, p < 0.05) in the rheumatoid arthritis group. CRP levels of the patient group correlated with kynurenine levels (r = 0.524, p < 0.03). Determination of tryptophan degradation and neopterin levels in chronic inflammatory disease may provide a better understanding of progression of the disease.

  3. Development of labial gingival recessions in orthodontically treated patients

    NARCIS (Netherlands)

    Renkema, Anne Marie; Fudalej, Piotr S.; Renkema, Alianne; Kiekens, Rosemie; Katsaros, Christos

    2013-01-01

    Introduction: Our aim was to assess the prevalence of gingival recessions in patients before, immediately after, and 2 and 5 years after orthodontic treatment. Methods: Labial gingival recessions in all teeth were scored (yes or no) by 2 raters on initial, end-of-treatment, and posttreatment (2 and

  4. Development of labial gingival recessions in orthodontically treated patients

    NARCIS (Netherlands)

    Renkema, A.M.; Fudalej, P.S.; Kiekens, R.M.A.; Katsaros, C.

    2013-01-01

    INTRODUCTION: Our aim was to assess the prevalence of gingival recessions in patients before, immediately after, and 2 and 5 years after orthodontic treatment. METHODS: Labial gingival recessions in all teeth were scored (yes or no) by 2 raters on initial, end-of-treatment, and posttreatment (2 and

  5. Osteonecrosis in patients with testicular tumours treated with chemotherapy.

    NARCIS (Netherlands)

    Berkmortel, F. van den; Wit, R. de; Rooy, J.W.J. de; Mulder, P.H.M. de

    2004-01-01

    The role of antiemetics is invaluable in allowing cancer patients to complete, otherwise possibly intolerable, chemotherapy. In the Perugia Consensus Conference it was decided that the recommended antiemetic regimen in the prevention of acute emesis induced by a single high, low and repeated doses o

  6. Prolactin levels and adverse events in patients treated with risperidone.

    Science.gov (United States)

    Kleinberg, D L; Davis, J M; de Coster, R; Van Baelen, B; Brecher, M

    1999-02-01

    Hyperprolactinemia is a common clinical disorder that may lead to sexual dysfunction or galactorrhea. It may arise from a variety of etiologies, including the use of antipsychotic agents, presumably because of a dopamine receptor blockade. This analysis was designed to characterize the relationship between risperidone, serum prolactin levels, and possible clinical sequelae. All data from randomized, double-blind studies of risperidone in patients with chronic schizophrenia were analyzed. The two largest studies (the North American and multinational trials) included 841 patients (259 women, 582 men) with paired prolactin level data and 1,884 patients (554 women, 1,330 men) with data on six adverse events possibly associated with increased prolactin levels (amenorrhea, galactorrhea, and decreased libido in women; erectile dysfunction, ejaculatory dysfunction, gynecomastia, and decreased libido in men). Both risperidone and haloperidol produced dose-related increases in plasma prolactin levels in men and women. Among women, the risperidone dose was not correlated with adverse events, nor were the adverse events correlated with endpoint prolactin levels. Among men, the incidence of adverse events was positively correlated with risperidone dose; however, at risperidone doses of 4 to 10 mg/day the incidence of adverse events was not significantly higher than that observed in patients receiving placebo. Furthermore, adverse events in men were unrelated to plasma prolactin levels. Risperidone-associated increase in serum prolactin levels was not significantly correlated to the emergence of possible prolactin-related side effects.

  7. Herpes zoster in psoriasis patients treated with tofacitinib

    DEFF Research Database (Denmark)

    Winthrop, Kevin L; Lebwohl, Mark; Cohen, Arnon D

    2017-01-01

    BACKGROUND: Tofacitinib is an oral Janus kinase (JAK) inhibitor. Immunomodulatory therapies can increase the risk for herpes zoster (HZ) in patients with psoriasis. OBJECTIVE: To evaluate the relationship between tofacitinib use and HZ risk. METHODS: We used phases 2 and 3 and long-term extension...

  8. Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer

    Science.gov (United States)

    2013-01-08

    Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Paroxysmal Nocturnal Hemoglobinuria; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Myeloid Leukemia; Refractory Anemia; Refractory Anemia With Ringed Sideroblasts; Relapsing Chronic Myelogenous Leukemia; Thrombocytopenia; Untreated Adult Acute Myeloid Leukemia

  9. 喜疗妥联合电磁疗治疗动静脉内瘘炎症的疗效观察%Evaluation on curative effect of hirudoid in combined to electromagnetic therapy to treat Inflammation of arteriovenous fistula

    Institute of Scientific and Technical Information of China (English)

    陈燕; 李桃梅; 范星

    2011-01-01

    Objective: To probe into the effect of hirudoid cream in combined to electromagnetic therapy to treat autogenous arteriovenous fistula (AVF) inflammation. Methods: A total of 42 AVF local inflammation patients randomly were divided into experimental group (22 cases) and control group (20 cases) , hirudoid in combined to electromagnetic therapy for experimental group cases and hirudoid therapy for control group cases. The therapeutic effect,the average time of curing,the condition of antibiotics use,the time of first use of AVF for hematodialysis after treatment and incidence of related complications were recorded. Results: Compared with control group,the cure rate was higher (P<0. 01) ,the average time of curing was shorter (P<0. 01) , and the combined rate of antibiotic was less (P<0. 01), and incidence of subsequent dialysis complications of experimental group was less (P<0. 05). Conclusion: The hirudoid in combined to electromagnetic therapy has the benefits of rapid onset, short duration and low cost and is effective for AVF inflammation in chronic renal failure patients undergoing maintenance hemodialysis%[目的]探讨喜疗妥联合电磁疗治疗自体动静脉内瘘(AVF)炎症的效果.[方法] AVF局部炎症病人42例,随机分喜疗妥联合电磁疗组22例和喜疗妥组20例,分别采用喜疗妥联合电磁疗治疗和喜疗妥治疗.记录两组病人疗效、治愈时间、合并使用抗生素情况,治疗后首次使用AVF行血液透析时间以及相关并发症发生情况等.[结果]喜疗妥联合电磁疗组病人治愈率明显高于喜疗妥组(P<0.01),治愈时间短于喜疗妥组(P<0.01),抗生素合用率明显少于喜疗妥组(P<0.01),后续透析并发症发生率明显低于喜疗妥组(P<0.05).[结论]喜疗妥联合电磁疗治疗起效快、疗程短、费用低,能有效用于慢性肾衰维持性血液透析病人AVF炎症的治疗.

  10. An observational study of glycemic control in canagliflozin treated patients.

    Science.gov (United States)

    Meckley, L M; Miyasato, G; Kokkotos, F; Bumbaugh, J; Bailey, R A

    2015-08-01

    To evaluate changes in glycemic control following the initial canagliflozin pharmacy claim in a real-world population. A retrospective cohort analysis of adult patients with type 2 diabetes mellitus (T2DM) was conducted using 2013 medical, pharmacy and laboratory claims from the Inovalon MORE 2 Registry. Patients with T2DM aged ≥18 years with ≥60 days of canagliflozin supply and HbA1c test results within 120 days before and ≥60 days after initial canagliflozin claim (defined as index date) were included. The differences between HbA1c levels pre- and post-index were assessed. Changes pre- and post-index in Healthcare Effectiveness Data and Information Set (HEDIS) glycemic control criteria of HbA1c 9% were evaluated. Subgroup analyses of patients with HbA1c >7% at baseline and patients aged ≥65 were also conducted. Among the 268 patients meeting the study criteria, mean HbA1c pre-index was 8.3% and post-index was 7.6%; the mean reduction in HbA1c pre-post index was 0.7% (95% CI: 0.6%, 0.9%). The proportions of patients meeting the HEDIS glycemic control measures (HbA1c 9%) improved and was significantly different pre- and post-index (all p 7% prior to index (81% of the cohort; mean pre-index HbA1c = 8.8%), HbA1c was reduced by 0.9% (95% CI: 0.8%, 1.1%). The aged ≥65 subgroup consisted of 15% of the cohort, with a pre-index HbA1c of 8.3%. The mean reduction in HbA1c test results pre- and post-canagliflozin index was 0.6% (95% CI: 0.4%, 0.9%). This analysis did not adjust for changes in antihyperglycemic agents during the study period. Patients with T2DM were observed to have improved glycemic control following initial canagliflozin pharmacy claim as measured by HbA1c change and attainment of specific glycemic control criteria.

  11. Survival of patients with hepatocellular carcinoma (HCC treated by percutaneous radio-frequency ablation (RFA is affected by complete radiological response.

    Directory of Open Access Journals (Sweden)

    Giuseppe Cabibbo

    Full Text Available BACKGROUND: Radio-frequency ablation (RFA has been employed in the treatment of Barcelona Clinic Liver Cancer (BCLC early stage hepatocellular carcinoma (HCC as curative treatments. AIM: To assess the effectiveness and the safety of RFA in patients with early HCC and compensated cirrhosis. METHODS: A cohort of 151 consecutive patients with early stage HCC (122 Child-Pugh class A and 29 class B patients treated with RFA were enrolled. Clinical, laboratory and radiological follow-up data were collected from the time of first RFA. A single lesion was observed in 113/151 (74.8%, two lesions in 32/151 (21.2%, and three lesions in 6/151 (4% of patients. RESULTS: The overall survival rates were 94%, 80%, 64%, 49%, and 41% at 12, 24, 36, 48 and 60 months, respectively. Complete response (CR at 1 month (p<0.0001 and serum albumin levels (p = 0.0004 were the only variables indipendently linked to survival by multivariate Cox model. By multivariate analysis, tumor size (p = 0.01 is the only variable associated with an increased likehood of CR. The proportion of major complications after treatment was 4%. CONCLUSIONS: RFA is safe and effective for managing HCC with cirrhosis, especially for patients with HCC ≤3 cm and higher baseline albumin levels. Complete response after RFA significantly increases survival.

  12. 饮食康复对糖尿病并发胃肠植物神经病变患者疗效观察%Curative observation of dietary recovery on patients of diabetes combined with gastrointestinal vegetative nervous lesion

    Institute of Scientific and Technical Information of China (English)

    王仲迪

    2001-01-01

    @@Background: It has been reported that there are 50% patients in type 2 diabetes combined with differential gastrointestinal vegetative nervous lesion.The main symptoms are: dysphagia,abdominalgia,diarrhea,constipation,satiety in morning,nausea and vomitting the foods taken before the last dinner or several hours,body weight's cutting down,low blood-glucose after supper,unstable blood-glucose etc,which caused the acceleration of patient's condition changes and the occurrence of other complications.Therefore,excepting actively decreasing blood-glucose and expectant treatments,the special dietary recovery care is necessary for patients of diabetes combined with gastrointestinal vegetative nervous lesion. Objective: To observe the curative effect of dietary care on patients of diabetes combined with gastrointestinal vegetative nervous lesion. Unit: People's Hospital of Shaoxing City. Subject: 172 in-patients of diabetes combined with gastrointestinal vegetative nervous lesion from June 1996 to March 2001.Among them,male 98 cases,female 74 cases,age 42~ 87.Duration of illness was 2~ 29 years.Clinical symptoms were: 26 cases with nausea or vomitting the foods taken before the last dinner,72 cases with satiety on epigastrium,22 cases with satiety in morning,42 cases with epigastric pain,56 cases with diarrhea,89 cases with constipation,7 cases with dysphagia.

  13. Ultrastructural Analysis of the Foreskin in Patients With True Phimosis Treated or Not Treated With Topical Betamethasone and Hyaluronidase Ointment.

    Science.gov (United States)

    Favorito, Luciano Alves; Gallo, Carla B M; Costa, Waldemar S; Sampaio, Francisco J B

    2016-12-01

    To evaluate, by using scanning electron microscopy (SEM), the possible alterations of the foreskin connective tissue in patients with true phimosis submitted to topical treatment with betamethasone and hyaluronidase ointment. We studied 15 patients (mean 5.3 years old) submitted or not to topical application of betamethasone 0.2% and hyaluronidase cream. For qualitative analysis of the connective tissue, we studied 5 samples from each foreskin, with 2 mm length. The samples were submitted to fixation for SEM by immersing tissue fragments in a modified Karnovsky solution for 48 hours at 4°C. The obtained acellular preparations were then processed for high-vacuum SEM, and observations were performed on a LEO 435 (Zeiss, Oberkochen, Germany) scanning electron microscope with an acceleration voltage of 15 to 20 kV. Parents of 7 children did not agree with the clinical treatment and opted for circumcision directly. These patients served as the control group (nontreated). Eight patients submitted to topical treatment could not expose the glans and were referred for circumcision. In SEM, with a magnification of 5000×, we observed important differences in the organization of the collagen and elastic system fibers when comparing treated and nontreated patients with betamethasone and hyaluronidase. Treated patients presented a different organization of collagen with a clear decrease in the elastic system fibers. The treatment of phimosis with betamethasone + hyaluronidase showed changes in the structure of the foreskin with a decrease of elastic system fibers, which is characteristic of the healing processes. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. The Role of Narrow Band Imaging in the Detection of Recurrent Laryngeal and Hypopharyngeal Cancer after Curative Radiotherapy

    Directory of Open Access Journals (Sweden)

    Michal Zabrodsky

    2014-01-01

    Full Text Available Narrow band imaging is considered a significant improvement in the possibility of detecting early mucosal lesion of the upper aerodigestive tract. Early detection of mucosal neoplastic lesions is of utmost importance for patients survival. There is evidence that, especially in patients previously treated by means of curative radiotherapy or chemoradiotherapy, the early detection rate of recurrent disease is quite low. The aim of this study was to prove whether the videoendoscopy coupled with NBI might help detect recurrent or secondary tumors of the upper aerodigestive tract. 66 patients previously treated by means of RT or CRT with curative intent were enrolled in the study. All patients underwent transnasal flexible videoendoscopy with NBI mode under local anesthesia. When a suspicious lesion was identified in an ambulatory setting, its nature was proved histologically. Many of these changes were not identifiable by means of conventional white light (WL endoscopy. The accuracy, sensitivity, specificity, and positive and negative predictive value of the method are very high (88%, 92%, 76%, 96%, and 91%, resp.. Results demonstrate that outpatient transnasal endoscopy with NBI is an excellent method for the follow-up of patients with carcinomas of the larynx and the hypopharynx primarily treated with radiotherapy.

  15. Immunological evaluation of rheumatoid arthritis patients treated with itolizumab

    OpenAIRE

    Aira, Lazaro E.; Hernández, Patricia; Prada, Dinorah; Chico, Araceli; Gómez, Jorge A.; González, Zuyén; Fuentes, Karla; Viada, Carmen; Mazorra, Zaima

    2015-01-01

    Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation that affects approximately 1% of the general population. Itolizumab, a monoclonal antibody specific for the human CD6 molecule mainly expressed on T lymphocytes, has been shown to inhibit proliferation of T cells and proinflammatory cytokine production in psoriasis patients. We have now assessed the immunological effect of itolizumab in combination with methotrexate in rheumatoid arthritis by analyzing clinical ...

  16. CNS Involvement in AML Patient Treated with 5-Azacytidine

    Directory of Open Access Journals (Sweden)

    Diamantina Vasilatou

    2014-01-01

    Full Text Available Central nervous system (CNS involvement in acute myeloid leukemia (AML is a rare complication of the disease and is associated with poor prognosis. Sometimes the clinical presentation can be unspecific and the diagnosis can be very challenging. Here we report a case of CNS infiltration in a patient suffering from AML who presented with normal complete blood count and altered mental status.

  17. Treating depression in HIV-positive patients affects adherence

    OpenAIRE

    M Y H Moosa; F Y Jeenah

    2012-01-01

    Aim. To determine changes in adherence to antiretroviral therapy (ART) in HIV-positive patients with depression, following treatment with an antidepressant or psychotherapy. Methods. The study was prospective, randomised and controlled. Consenting volunteers aged ≥18 years and stable on ART for ≥6 months were included in the study. Sociodemographic data were obtained, and a clinical diagnostic evaluation and the Hamilton Depression rating scale (HAMD) were performed on all subjects at en...

  18. Hepatitis C: Treatment of difficult to treat patients

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Over the past several years, more so recently, treatmentoptions for hepatitis C virus (HCV) have seemed toexponentially grow. Up until recently, the regimen ofpegylated interferon (peg-IFN) and ribavirin (RBV) stoodas the standard of care. Direct acting antivirals, whichtarget nonstructural proteins involved in replicationand infection of HCV were first approved in 2011 as anaddition to the peg-IFN and RBV regimen and with themhave come increased sustained virological response rates(SVR). The previously reported 50%-70% SVR ratesusing the combination of peg-IFN and RBV are no longerthe standard of care with direct acting antiviral (DAA)based regimens now achieving SVR of 70%-90%. Peg-IFN free as well as "all oral" regimens are also available.The current randomized controlled trials available showfavorable SVRs in patients who are naive to treatment,non-cirrhotic, and not human immunodeficiency virus(HIV)-co-infected. What about patients who do notfit into these categories? In this review, we aim todiscuss the currently approved and soon to be approvedDAAs while focusing on their roles in patients that aretreatment experienced, cirrhotic, or co-infected with HIV.In this discussion, review of the clinical trials leadingto recent consensus guidelines as well as discussion ofbarriers to treatment will occur. A case will attempt willbe made that social services, including financial supportand drug/alcohol treatment, should be provided to allHCV infected patients to improve chances of cure andthus prevention of late stage sequela.

  19. Primary CNS lymphoma in a patient treated with azathioprine

    DEFF Research Database (Denmark)

    Glesner, Matilde Kanstrup; Ocias, Lukas Frans; Larsen, Thomas Stauffer;

    2014-01-01

    with surrounding oedema. There was cerebrospinal fluid pleocytosis, and Epstein-Barr virus (EBV) DNA was detected in the spinal fluid by PCR. A brain biopsy confirmed the suspicion of primary brain lymphoma. EBV-associated primary brain lymphoma is a relevant differential diagnosis in patients with long......-standing immune suppression presenting with neurological symptoms. Detection of EBV DNA in the spinal fluid together with characteristic radiological findings may serve as a diagnostic clue for a quick diagnosis....

  20. Osteoradionecrosis of the mandibula in patients treated with different fractionations

    Energy Technology Data Exchange (ETDEWEB)

    Studer, G.; Glanzmann, C. [Dept. of Radiation Oncology, Univ. Hospital Zurich (Switzerland); Graetz, K.W. [Dept. of Cranio-Maxillo-Facial Surgery, Univ. Hospital Zurich (Switzerland)

    2004-04-01

    Purpose: the incidence of osteonecrosis of the mandibula (ON) after irradiation using modern three-dimensional planning as well as hyperfractionation or moderately accelerated irradiation has been evaluated and compared with the incidence of the preceding period. Patients and methods: the records of 268 head and neck cancer patients irradiated between January 1, 1980 and December 31, 1998 with a dose to the mandibula of at least 60 Gy were retrospectively analyzed. All patients had CT-based treatment planning, computerized dose calculation with isodose charts also in several off-axis planes, and regular verification films. Results: the long-term cumulative incidence of ON needing mandibular resection was as follows: after conventional fractionation 6.2% (between 60 and 66.6 Gy target dose) or 20.1% (between > 66.6 and 72 Gy); after hyperfractionated irradiation with a target dose between 72 and 78.8 Gy 6.6%; after concomitant boost irradiation according to the MDA/Houston regime with a dose between 63.9 and 70.5 Gy: no case; after 6 x 2 Gy/week or 7 x 1.8 Gy/week and a total target dose between 66 and 72 Gy approximately 17% or higher (small patient number). Conclusion: comparison of the incidence of ON during the period between 1980 and 1990 with the following period between 1990 and 1998 shows a decrease in risk to a value of approximately 5% using modern three-dimensional techniques as well as hyperfractionation or moderately accelerated fractionation. (orig.)

  1. Basal cell carcinomas in elderly patients treated by cryotherapy.

    Science.gov (United States)

    Chiriac, Anca; Mihaila, Doina; Foia, Liliana; Solovan, Caius

    2013-01-01

    Basal cell carcinoma is a malignant skin tumor with high incidence in our country, especially in rural areas, on sun-exposed skin (particularly on the face) in elderly patients. We present three cases of basal cell carcinoma with good results with cryotherapy. This report aims to outline and to prove that in some difficult situations, a simple, inexpensive, easy-to-perform procedure with no contraindications and with minimal side effects (erythema, mild pain) can be applied and resolve such cases.

  2. Options for treating postherpetic neuralgia in the medically complicated patient

    Directory of Open Access Journals (Sweden)

    Bruckenthal P

    2013-08-01

    Full Text Available Patricia Bruckenthal,1 Robert L Barkin2,31Department of Graduate Studies in Advanced Practice Nursing, Stony Brook University School of Nursing, Stony Brook, NY, USA; 2Department of Anesthesiology, Family Medicine, and Pharmacology, Rush University Medical College, Chicago, IL, USA; 3Department of Anesthesiology, Northshore University Health System Pain Centers, Skokie and Evanston Hospitals, Skokie and Evanston, IL, USAAbstract: Patients with postherpetic neuralgia (PHN are often of advanced age or immunocompromised and likely to have ≥1 comorbid medical condition for which they receive ≥1 medication (polypharmacy. Comorbidities affecting renal or hepatic function can alter pharmacokinetics, thereby impacting the efficacy or tolerability of PHN analgesic therapies. Cardiovascular, cerebrovascular, or psychiatric comorbidities may increase patient vulnerability to potential adverse events associated with some PHN analgesic therapies. Because PHN is a localized condition, localized therapy with a topical analgesic (lidocaine patch 5% and capsaicin 8% patch or cream may provide adequate efficacy while mitigating the risk of systemic adverse events compared with oral analgesics (eg, tricyclic antidepressants, anticonvulsants, opioids. However, combined therapy with a topical and an oral analgesic or with >1 oral analgesic may be needed for optimal pain management in some patients. This review summarizes how comorbidities and concomitant medications should be taken into account when selecting among available pharmacotherapies for PHN and provides recommendations for the selection of therapies that will provide analgesia while minimizing the risk of adverse events.Keywords: calcium channel α2-δ ligand, comorbidities, lidocaine patch, polypharmacy, postherpetic neuralgia, TCA

  3. PET studies of parkinsonian patients treated with autologous adrenal implants.

    Science.gov (United States)

    Guttman, M; Burns, R S; Martin, W R; Peppard, R F; Adam, M J; Ruth, T J; Allen, G; Parker, R A; Tulipan, N B; Calne, D B

    1989-08-01

    Transplantation of autologous adrenal medulla tissue into the striatum has recently been proposed as a treatment for Parkinson's disease. We report the use of positron emission tomography (PET) to evaluate patients who had adrenal implants placed into the right caudate. 6-[18F] fluoro-L-dopa (6-FD) scans were performed to study the integrity and activity of the implant, and the nigrostriatal dopamine system before and six weeks after transplantation surgery. [68Ga] Gallium-ethylenediaminetetraacetate (Ga) scans were also performed to assess the blood brain barrier. The Ga scans performed on two patients showed increased permeability of the blood brain barrier at the surgical site. 6-FD PET scans in five patients did not show a consistent change in striatal uptake following adrenal medullary implantation after six weeks. Further assessment of implant viability with 6-FD PET scans after longer follow up may provide useful information if the blood-brain barrier becomes re-established with the passage of time.

  4. [The efficacy of treating patients with intraocular hemorrhages with emoxypin].

    Science.gov (United States)

    Mokhammad, I; Cherkasov, I S

    1990-01-01

    Emoxipin, a home-made preparation approved by the Pharmacological Committee for clinical usage in 1986, is a retinal protector. Its usage is indicated for treatment of chorioretinitis, diabetic retinopathy, thrombosis of retinal vessels as well as to protects the retina from a damaging action of light of high intensity. In order to study therapeutic effectiveness of emoxipin in intraocular hemorrhages of different genesis, the preparation was used subconjunctivally, 0.5 ml of a 1% solution daily for 10-15 days. Emoxipin was used in 29 patients (29 eyes) with intraocular hemorrhages, of them, due to contusion of the eye--in 19, hypertonic disease--in 6, thrombosis of the central retinal vein--in 2, after intraocular operations--in 2 patients. As a result of the treatment, partial or almost total resolution of hemorrhages and a rise of visual acuity of different degree were recorded in all patients. Before treatment, visual acuity was from light perception to 0.04 in 26 eyes, from 0.09 to 0.3 in 3 eyes. After treatment, it rose to 0.1-0.2 in 12 eyes, to 0.3-1.0--in 17 eyes.

  5. Effects of a 24-week course of interferon-α therapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    AIM: To assess whether a 24-wk course of interferon (IFN) could prevent hepatocellular carcinoma (HCC) recurrence and worsening of liver function in patients with hepatitis C virus (HCV)-infected patients after receiving curative treatment for primary HCC. METHODS: Outcomes in 42 patients with HCV infection treated with IFN-α, after curative treatment for primary HCC (IFN group), were compared with 42 matched curatively treated historical controls not given IFN (nonIFN group). RESULTS: Although the rate of initial recurrence did not differ significantly between IFN group and non-IFN group (0%, 44%, 61%, and 67% vs 4.8%, 53%, 81%, and 87% at 1, 3, 5, and 7 years, P = 0.153, respectively), IFN group showed a lower rate than the non-IFN group for second recurrence (0%, 10.4%, 28%, and 35% vs 0%, 30%, 59%, and 66% at 1, 3, 5 and 7 years, P = 0.022, respectively). Among the IFN group, patients with sustained virologic response (SVR) were less likely to have a second HCC recurrence than IFN patients without an SVR, or non-IFN patients. Multivariate analysis identified the lack of SVR as the only independent risk factor for a second recurrence, while SVR and Child-Pugh class A independently favored overall survival. CONCLUSION: Most intrahepatic recurrences of HCVrelated HCC occurred during persistent viral infection. Eradication of HCV is essential for the prevention of HCC recurrence and improvement of survival.

  6. Curative effect observation of electrical stimulation to cerebellar fastigial nucleus on nerve function recovery of cerebral infarction patients%电刺激小脑顶核对脑梗死患者神经功能恢复的疗效观察

    Institute of Scientific and Technical Information of China (English)

    彭昌鼎; 孙鸣; 王昌铭; 吉国泰; 姬向丽

    2002-01-01

    Objective To observe curative effect of electrical stimulation cerebellar fastigial nucleus on nerve function recovery of cerebral infarction patients.Method The patients were treated with electrical stimulation cerebellar fastigial nucleus except for routine drugs,the electrode were placed on the bilateral mastoid processes,giving pulse electric current for forty minutes two times per day,for a 10 day couse treatment.The parameter was set at model 1,frequency was 131% ~ 136% and intensity was 70% ~ 90% .Result Total effective rate of therapeutic group and control group were 91.7% and 71.4% separately.χ 2=4.860(P< 0.05).The nerver function defect score was manifestly decreased.There was a significant difference between the therapeutic group and control group,and between before and after treatment in therapeutic group(P< 0.01).Conclusion The experiment suggested that the treatment of cerebral infarction by drugs except adding electrical stimulation of cerebellar fastigial nucleus is better than by drugs along.The electrical stimulation of cerebellar fastigial nucleus has obvious protective effect.It can promote recovery of cerebral infarction.

  7. Meta Analysis of Xiao-Qinglong Decoction in Treating Asthma Clinical Curative Effect%小青龙汤治疗哮喘临床疗效 Meta 分析

    Institute of Scientific and Technical Information of China (English)

    吴治谚; 金晓飞; 蒋孟良

    2014-01-01

    目的:评价小青龙汤在治疗哮喘时的临床疗效。方法:使用文献搜索引擎中国知网( CNKI)、万方数据库、中国生物医学文献数据库(CBM)对小青龙汤治疗哮喘的文献进行搜索,而后进行meta分析。结果:使用小青龙汤的观察组其总有效率与临床控制率均高于使用常规哮喘药物的对照组的总有效率与临床控制率。结论:小青龙汤对哮喘的治疗效果要比常规哮喘药物之治疗效果更加优秀。%Objective to evaluate the small qinglong decoction in the treatment of asthma in the clinical curative effect .Methods using lit-erature search engine China hownet (CNKI), a database of ten thousand , the Chinese biomedical literature database (CBM) for small qinglong decoction in the treatment of asthma literature search , and meta analysis .Results using a small Xiao -QingLong decoction treatment group the total effective rate and clinical control rates were higher than using conventional control group total effective rate and clinical asthma drug control .Conclusion the effect of Xiao -QingLong decoction in the treatment of asthma is more outstanding than conventional treatment of asthma drug effect .

  8. LICC: L-BLP25 in patients with colorectal carcinoma after curative resection of hepatic metastases--a randomized, placebo-controlled, multicenter, multinational, double-blinded phase II trial

    Directory of Open Access Journals (Sweden)

    Schimanski Carl

    2012-04-01

    Full Text Available Abstract Background 15-20% of all patients initially diagnosed with colorectal cancer develop metastatic disease and surgical resection remains the only potentially curative treatment available. Current 5-year survival following R0-resection of liver metastases is 28-39%, but recurrence eventually occurs in up to 70%. To date, adjuvant chemotherapy has not improved clinical outcomes significantly. The primary objective of the ongoing LICC trial (L-BLP25 In Colorectal Cancer is to determine whether L-BLP25, an active cancer immunotherapy, extends recurrence-free survival (RFS time over placebo in colorectal cancer patients following R0/R1 resection of hepatic metastases. L-BLP25 targets MUC1 glycoprotein, which is highly expressed in hepatic metastases from colorectal cancer. In a phase IIB trial, L-BLP25 has shown acceptable tolerability and a trend towards longer survival in patients with stage IIIB locoregional NSCLC. Methods/Design This is a multinational, phase II, multicenter, randomized, double-blind, placebo-controlled trial with a sample size of 159 patients from 20 centers in 3 countries. Patients with stage IV colorectal adenocarcinoma limited to liver metastases are included. Following curative-intent complete resection of the primary tumor and of all synchronous/metachronous metastases, eligible patients are randomized 2:1 to receive either L-BLP25 or placebo. Those allocated to L-BLP25 receive a single dose of 300 mg/m2 cyclophosphamide (CP 3 days before first L-BLP25 dose, then primary treatment with s.c. L-BLP25 930 μg once weekly for 8 weeks, followed by s.c. L-BLP25 930 μg maintenance doses at 6-week (years 1&2 and 12-week (year 3 intervals unless recurrence occurs. In the control arm, CP is replaced by saline solution and L-BLP25 by placebo. Primary endpoint is the comparison of recurrence-free survival (RFS time between groups. Secondary endpoints are overall survival (OS time, safety, tolerability, RFS/OS in MUC-1 positive

  9. XK469R in Treating Patients With Refractory Hematologic Cancer

    Science.gov (United States)

    2013-02-07

    Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Refractory Chronic Lymphocytic Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Myelodysplastic Syndromes; Stage III Chronic Lymphocytic Leukemia; Stage IV Chronic Lymphocytic Leukemia; Untreated Adult Acute Myeloid Leukemia

  10. Observation of the Curative Effect of MEBT/MEBO in Treating Pediatric Burn%烧伤皮肤再生医疗技术治疗小儿烧伤的疗效观察

    Institute of Scientific and Technical Information of China (English)

    孙记燕; 赵贤忠

    2015-01-01

    Objective To investigate the effects of moist exposed burn treatment/moist exposed burn ointment ( MEBT/MEBO) in treating pediatric burn. Methods 98 cases of burn patients treated in our hospital from April 2015 to April 2012 were selected. According to simple randomization method, they were divided into the observation group and the control group, each with 49 cases. The control group was given conventional treatment, while the observation group was given MEBT/MEBO treatment. Results The observa-tion group was less or fewer than the control group in terms of the wound area, wound healing time, graft number and scar healing ca-ses, with statistically significant difference (P<0. 05) . There were 5 cases in the observation group with wound infection (10. 2%), compared with 13 cases in the control group (26. 5%) and the difference was statistically significant (χ2=4. 356, P=0. 037, <0. 05) . Conclusion MEBT/MEBO can narrow the wound area, promote wound healing, reduce skin graft and scar hyperplasia and effectively decrease the rate of wound infection. It is an ideal treatment for children with burns.%目的 探讨烧伤皮肤再生医疗 ( MEBT/MEBO) 技术对小儿烧伤的临床疗效. 方法 选取我院2012 年4 月至2015年4月收治住院治疗的烧伤患儿98例的临床资料. 按照随机数字表的分组方法将98例患儿分为观察组和对照组, 各49例. 对照组给予常规治疗, 观察组给予MEBT/MEBO技术治疗. 结果 观察组患儿创面面积、 愈合时间、 植皮数及瘢痕愈合例数均低于对照组, 两组比较差异有统计学意义 ( P<0. 05 ). 观察组创面感染5例 ( 10. 2%) , 对照组创面感染13例(26. 5%), 两组比较差异有统计学意义 (χ2=4. 356, P=0. 037<0. 05). 结论 MEBT/MEBO技术能够缩小创面面积、 加快创面愈合时间、 减少植皮数及瘢痕增生, 可有效预防局部感染的发生, 是小儿烧伤的理想治疗方案.

  11. Emergency management of patients being treated with oral anticoagulants

    Directory of Open Access Journals (Sweden)

    Franco Manzato

    2013-12-01

    Full Text Available Vitamin K antagonists (VKA are among the most widely prescribed drugs in the industrialized world. In fact, for decades, VKA have been the only orally available anticoagulant for the primary and secondary prevention of venous and arterial thrombotic events. Their efficacy has been widely demonstrated in a series of studies carried out in the 1990s. Since the incidences of atrial fibrillation and venous thromboembolism increase exponentially with age, the number of anticoagulated patients is destined to increase. This paper examines anticoagulation therapy management with particular attention to the use of VKA.

  12. Chronic Thromboembolic Pulmonary Hypertension: Treat the Patient Not the Haemodynamics

    Directory of Open Access Journals (Sweden)

    Ben Dunne

    2012-01-01

    Full Text Available Chronic thromboembolic pulmonary hypertension (CTEPH is a disabling condition that is being increasingly recognised. It is unique as a cause of pulmonary hypertension in that it is surgically curable. We wish to highlight the importance of recognition and early referral of any patient who may have CTEPH even in the absence of resting pulmonary hypertension as excellent results can be achieved by restoring pulmonary vascular anatomy, reducing exercise-induced pulmonary hypertension, and reducing dead-space ventilation. We present a case that illustrates these points and discuss our experience as a referral centre for CTEPH.

  13. An Ageusia and Dysosmia Patient Treated by Acupuncture

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Occurrence of ageusia, a disease characterized by complete or severe loss of the subjective sense of taste and frequently accompanied with olfaction disorders, is increasing at the rate of 140 thousand more cases every year in Japan according to the latest congressional data, 2002(1). There may be many reasons for this, such as influenza, diabetes, adverse reaction of antimicrobial drugs, smoke, depression, etc. Disorders of taste and smell could not only cause uncomfort, but also result in a loss of body weight in the patients, and may be harmful to their quality of life(2).

  14. [The use of prostatilen in treating patients with prostatic diseases].

    Science.gov (United States)

    Vozianov, A F; Gorpinchenko, I I; Boĭko, N I; Drannik, G N; Khavinson, V Kh

    1991-01-01

    A clinical trial of polypeptide prostatic preparation prostatilen has been performed in 37 and 15 patients with chronic prostatitis and prostatic adenoma, respectively. The treatment resulted in attenuation of algetic and dysuria symptoms. Copulative function and spermatogenesis improved. The uroflowmetric index rose, while residual urine and leukocyte count in prostatic secretion reduced. The drug demonstrated antibacterial and immunomodulation effects in the absence of adverse reactions. Prostatilen is indicated in: chronic prostatitis, prostatic adenoma stage I, normospermatogenic and toxic sterility, interoceptive copulative dysfunction, dysuria. The drug in recommended for clinical application.

  15. PROMISES FOR TREATING COLON CANCER PATIENTS WITH BRAF GENE MUTATION

    Directory of Open Access Journals (Sweden)

    M. Yu. Fedyanin

    2014-01-01

    Full Text Available Colon cancer represents a heterogenous disease group, which differ by cancerogenesis mechanisms, molecular alterations, prognosis and treatment possibilities. In modern clinical practice assessment of KRAS and NRAS genes status is already necessary in order to prescribe anti-EGFR treatment for metastatic disease. A separate poor prognosis group are patients with BRAF mutation. In this review we will focus on biological features of BRAF-mutant colorectal cancer, its epidemiology, clinical features on different stages, treatment choice and promising new treatment possibilities.

  16. Telemedicine-based physician consultation results in more patients treated and released by ambulance personnel

    DEFF Research Database (Denmark)

    Raaber, Nikolaj; Bøtker, Morten T; Riddervold, Ingunn S

    2016-01-01

    . In the intervention period, the EMCC was manned 24/7 with physicians experienced in emergency care. Eligible participants included all patients with nonurgent conditions receiving an ambulance after a medical emergency call. Ambulance personnel assessed patients and subsequently performed a telephone consultation...... a physician at the EMCC and ambulance personnel and noncritically ill 1-1-2 patients results in an increased rate of patients treated and released with high satisfaction. The approach does not seem to compromise patient safety....

  17. Immunological evaluation of rheumatoid arthritis patients treated with itolizumab

    Science.gov (United States)

    Aira, Lazaro E.; Hernández, Patricia; Prada, Dinorah; Chico, Araceli; Gómez, Jorge A.; González, Zuyén; Fuentes, Karla; Viada, Carmen; Mazorra, Zaima

    2016-01-01

    Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation that affects approximately 1% of the general population. Itolizumab, a monoclonal antibody specific for the human CD6 molecule mainly expressed on T lymphocytes, has been shown to inhibit proliferation of T cells and proinflammatory cytokine production in psoriasis patients. We have now assessed the immunological effect of itolizumab in combination with methotrexate in rheumatoid arthritis by analyzing clinical samples taken from 30 patients enrolled in a clinical trial. T and B cell subpopulations were measured at different time points of the study. Plasma cytokine levels and anti-idiotypic antibody response to itolizumab were also evaluated. The combined treatment of itolizumab and methotrexate led to a reduction in the frequency of T cell subpopulations, and plasma levels of proinflammatory cytokines showed a significant decrease up to at least 12 weeks after treatment ended. No anti-idiotypic antibody response was detected. These results support the relevance of the CD6 molecule as a therapeutic target for the treatment of this disease. PMID:26466969

  18. Immunological evaluation of rheumatoid arthritis patients treated with itolizumab.

    Science.gov (United States)

    Aira, Lazaro E; Hernández, Patricia; Prada, Dinorah; Chico, Araceli; Gómez, Jorge A; González, Zuyén; Fuentes, Karla; Viada, Carmen; Mazorra, Zaima

    2016-01-01

    Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation that affects approximately 1% of the general population. Itolizumab, a monoclonal antibody specific for the human CD6 molecule mainly expressed on T lymphocytes, has been shown to inhibit proliferation of T cells and proinflammatory cytokine production in psoriasis patients. We have now assessed the immunological effect of itolizumab in combination with methotrexate in rheumatoid arthritis by analyzing clinical samples taken from 30 patients enrolled in a clinical trial. T and B cell subpopulations were measured at different time points of the study. Plasma cytokine levels and anti-idiotypic antibody response to itolizumab were also evaluated. The combined treatment of itolizumab and methotrexate led to a reduction in the frequency of T cell subpopulations, and plasma levels of proinflammatory cytokines showed a significant decrease up to at least 12 weeks after treatment ended. No anti-idiotypic antibody response was detected. These results support the relevance of the CD6 molecule as a therapeutic target for the treatment of this disease.

  19. [The use of prostatilen in treating patients with chronic prostatitis].

    Science.gov (United States)

    Tkachuk, V N; Gorbachev, A G; Khavinson, V Kh

    1991-01-01

    Conventional methods of chronic prostatitis treatment aimed at destruction of pathogenic microflora have certain shortcomings. A promising approach is biologic control of prostatic function. A trial was performed of a new drug prostatilen which is a polypeptide isolated from the animal prostate. The study included 307 patients with chronic prostatitis of 4 mon to 36 years duration. Their age ranged from 18 to 74 years. The drug dose of 5-10 mg was administered once a day i.m. for 5-10 days. The immediate effect and long-term one were measured upon the treatment completion and 4-6 months later. A clinical effect manifested following 2-3 injections and grew to maximal values after 5-6 ones. In rare cases the treatment lasted up to 8-10 injections. The drug promoted disappearance or attenuation of the symptoms in 96.7% of the patients. Positive shifts were achieved in pain complaints, diuresis, sexual function, sleep, general condition. The subjective response agreed with objective laboratory and urodynamic evidence. Prostatilen proved effective for chronic prostatitis because it is tolerable, induces no side effects, beneficial in combinations with other modalities in management of this persistent and prone to recurrences disease.

  20. Definitive Chemoradiation Therapy Following Surgical Resection or Radiosurgery Plus Whole-Brain Radiation Therapy in Non-Small Cell Lung Cancer Patients With Synchronous Solitary Brain Metastasis: A Curative Approach

    Energy Technology Data Exchange (ETDEWEB)

    Parlak, Cem, E-mail: cemparlak@gmail.com [Department of Radiation Oncology, Baskent University, Adana Medical Faculty, Adana (Turkey); Mertsoylu, Hüseyin [Department of Medical Oncology, Baskent University, Adana Medical Faculty, Adana (Turkey); Güler, Ozan Cem; Onal, Cem; Topkan, Erkan [Department of Radiation Oncology, Baskent University, Adana Medical Faculty, Adana (Turkey)

    2014-03-15

    Purpose/Objectives: The aim of this study was to evaluate the impact of definitive thoracic chemoradiation therapy following surgery or stereotactic radiosurgery (SRS) and whole-brain radiation therapy (WBRT) on the outcomes of patients with non-small cell lung cancer (NSCLC) with synchronous solitary brain metastasis (SSBM). Methods and Materials: A total of 63 NSCLC patients with SSBM were retrospectively evaluated. Patients were staged using positron emission tomography-computed tomography in addition to conventional staging tools. Thoracic radiation therapy (TRT) with a total dose of 66 Gy in 2 Gy fractions was delivered along with 2 cycles of cisplatin-based chemotherapy following either surgery plus 30 Gy of WBRT (n=33) or SRS plus 30 Gy of WBRT (n=30) for BM. Results: Overall, the treatment was well tolerated. All patients received planned TRT, and 57 patients (90.5%) were also able to receive 2 cycles of chemotherapy. At a median follow-up of 25.3 months (7.1-52.1 months), the median months of overall, locoregional progression-free, neurological progression-free, and progression-free survival were 28.6, 17.7, 26.4, and 14.6, respectively. Both univariate and multivariate analyses revealed that patients with a T1-T2 thoracic disease burden (P=.001), a nodal stage of N0-N1 (P=.003), and no weight loss (P=.008) exhibited superior survival. Conclusions: In the present series, surgical and radiosurgical treatments directed toward SSBM in NSCLC patients were equally effective. The similarities between the present survival outcomes and those reported in other studies for locally advanced NSCLC patients indicate the potentially curative role of definitive chemoradiation therapy for highly selected patients with SSBM.

  1. Prevalence and predictors of cognitive dysfunction in opioid-treated patients with cancer: a multinational study

    DEFF Research Database (Denmark)

    Kurita, Geana P; Sjøgren, Per; Ekholm, Ola;

    2011-01-01

    PURPOSE To identify prevalence and associated factors of cognitive dysfunction in opioid-treated patients with cancer. PATIENTS AND METHODS EPOS (European Pharmacogenetic Opioid Study) is a prospective cross-sectional multicenter study in which adult patients with cancer who received treatment...

  2. 五苓散合五皮饮治疗肝硬化腹水58例疗效观察%Curative Effect Observation of 58 Cases of Cirrhosis Ascites Treated with Wuling Powder and Wupi drink

    Institute of Scientific and Technical Information of China (English)

    张帆

    2013-01-01

    目的:观察五苓散合五皮饮治疗肝硬化腹水的疗效。方法:将89例患者随机分成对照组31例,治疗组58例,对照组予以口服双氢克尿噻25mg 口服,每天3次,安体舒通口服20mg 每天3次治疗;治疗组单纯口服五苓散和五皮饮基础方加减,观察患者症状分级与评分情况。治疗组总有效率98.3%,对照组结果总有效率83.7%。治疗组总有效率优于对照组(P<0.05)结论:五苓散合五皮饮基础方可作为治疗肝硬化腹水专病专方推广。%Objective:To observe the clinical effect of Wuling Powder and Wupi Drink in the treatment of cirrhosis ascites.Method:The 89 patients were divided into two groups randomly, 31 of them were put into the control group, and the other 58 were put into the treatment group. The control group was given oral hydrochlorothiazide, 25mg tid, and spironolactone, 20mg tid. The treatment group was treated with a combination of Wuling powder and Wupi drink. Col ect the symptomatic grading and the score of the scales after observation.Results:The total effective rate of the treatment group were 98.3%, which was higher than the total effective rate in controls which is 83.7%.(P<0.05).Conclusion:Experiments proves that Wuling powder and Wupi drink in combination works in the treatment of cirrhosis ascites and is worth to generalize the use of it.

  3. 针灸加推拿正骨手法配合牵引与推拿正骨手法配合牵引治疗腰椎间盘突出症的对比疗效观察%Comparison of Curative Effect Observation of Acupuncture Add Massage Manipulation with Traction and Manipulation of Massage with Traction on Treating Prolapse of Lumbar Intervertebral Disc

    Institute of Scientific and Technical Information of China (English)

    胡英

    2013-01-01

    目的:对比针灸加推拿正骨手法配合牵引与推拿正骨手法配合牵引治疗腰椎间盘突出症的疗效.方法:将94例患者随机分为针灸加推拿正骨手法配合牵引治疗组(47例),推拿正骨手法配合牵引治疗组(47例),两组均使用ATA-ⅡD型腰椎自动牵引床行间歇牵引,每日1次,10天为1疗程,在4个疗程后观察评定疗效.结果:针灸加推拿正骨手法配合牵引治疗组总有效率为87.23%,推拿正骨手法配牵引组总有效率为80.85%,两组差异显著(P<0.05).结论:针灸加推拿正骨手法配合牵引较推拿正骨手法配合牵引疗效更佳.%Objective:To compare the effect of acupuncture add massage manipulation with traction and manipulation of massage with traction to treat prolapse of lumbar intervertebral disc.Methods:94 patients were randomly divided into treatment groups with 47 cases for acupuncture add massage manipulation with traction and treatment groups with 47 cases for massage manipulation with traction.Both two groups were using ATA-Ⅱ D type automatic traction beds,1 time a day and 10 days for 1 course.After 4 courses of treatment,curative effects of both methods were compared.Results:The total effective rate for acupuncture add massage manipulation with traction was 87.23%,while the rate for manipulation of massage with traction group was 80.85%.Difference about treatment effects between the two groups was significant (P<0.05).Conclusion:Acupuncture add massage manipulation with traction has better curative effects than that of manipulation of massage with traction.

  4. 躯体形式障碍患者人格倾向与临床疗效%A Study of Personality Disorder Tendencies and Curative Effect in Patients with Somatoform Disorder

    Institute of Scientific and Technical Information of China (English)

    马闯胜; 邵玉单; 邱松伟; 杨靖; 张淑芳

    2016-01-01

    Objective :To study the personality disorder tendencies and curative effect in patients with somatoform disorder .Methods :58 patients with somatoform disorders were assessed by personality diagnostic questionnaire (PDQ- 4) ;Patients with positive personality disorders screening were in study group ,others were in control group ,all pa‐tients were treated with paroxetine for 8 weeks .The efficacy were evaluated with Symptom Checklist - 90(SCL - 90) before the treatment and after 2 ,4 ,8 weeks .Results :In the 58 patients ,the positive of personality disorders screening were 34 cases(58 .62% ) ,the anxious group was 30 cases(51 .72% ) ,odd or eccentric group was 24 cases(41 .38% ) , dramatic and erratic group was 23 cases(39 .66% ) ,the frequent types of personality disorders were obsessive - com‐pulsive(29 cases ,50 .00% ) ,avoidant(22 cases ,37 .93% )and paranoid(21 cases ,36 .21% ) .After treatment ,the obvious effective rate and total effective rate of study group were 50 .00% and 85 .29% ,the control group were 54 .17% and 87 .50% ,there were no difference between two groups(χ2 = 0 .098 and 0 .022 P > 0 .05) .the scores o f somatiz ation , anxiety and dep ression factor o f SCL - 90 were reduced significantly in two groups after treatment(P < 0 .01) , there were significantly difference between two groups in somatization factor at 4 week and in anxiety factor at 4 ,8 week(P < 0 .05) .Conclusion :Somatoform disorder patients have high tendency for personality disorder .There is simi‐lar efficacy with all patients .The patients of negative of personality disorders screening have better efficacy than oth ‐ers in symptom of somatization and anxiety .%目的:调查躯体形式障碍患者的人格障碍倾向,比较帕罗西汀对有人格障碍倾向患者的临床疗效。方法:应用人格诊断问卷第4版(PDQ -4)对符合研究条件的58例躯体形式障碍患者筛查,筛查阳性的患者作为研究组,其余分入对照组,

  5. 锁定接骨板治疗老年肱骨近端骨折的术后并发症与远期疗效分析%Analysis of postoperative complications and long-term curative effect of elderly patients with proximal humerus fractures by locking proximal humerus plate

    Institute of Scientific and Technical Information of China (English)

    朱建举; 罗灵敏

    2016-01-01

    Objective To analyze the postoperative complications and long-term curative effect analysis of elderly patients with proximal humerus fractures by locking proximal humerus plate,and provide reference for such patients’clinical treatment.Methods A total of 92 elder patients with proximal humerus fractures in our hospital from September 2012 to September 2014 were included in the research.They were divided into control group (who were treated with anatomical bone plates)and observation group (who were treated with locking plates),according to different sugrical methods.The postoperative complications situation and long-term curative effect analysis of two groups were compared.Results The proportions of humerus head varus malunion and humerus head necrosis of observation group were less than those of control group,with statistically significant difference(P <0.05).And after six months of follow-up,the excellent rate of observation group were 89.1%,significantly more than control group 67.4%,with statistically significant difference(P <0.05).Conclusion The loc-king plate used in elderly patients with proximal humerus fractures can effectively reduce the occurrence of postoperative complications,and it has excellent long-term curative effect.%目的:分析锁定接骨板治疗老年肱骨近端骨折的术后并发症情况与远期疗效,为提高该类患者的临床治疗提供参考依据。方法选取2012年9月至2014年9月在本院接受手术治疗的92例老年肱骨近端骨折患者为研究对象,按手术方法分为对照组(解剖接骨板治疗)和观察组(锁定接骨板治疗),各46例。比较2组患者的并发症发生情况和远期疗效。结果观察组患者术后出现肱骨头内翻畸形愈合和肱骨头坏死的比例均少于对照组,差异均有统计学意义(P <0.05)。随访6个月后,观察组患者的治疗优良率为89.1%,高于对照组的67.4%,差异具有统计学意义(P <0

  6. 饮食护理干预对糖尿病肾病患者饮食治疗依从性的影响%Effect of diet nursing intervention on curative compliance of patients with diabetic nephropathy

    Institute of Scientific and Technical Information of China (English)

    李妙玲

    2012-01-01

    Objective To investigate the effect of diet nursing intervention on the curative compliance of patients with diabetic nephropathy. Methods 171 patients with diabetic nephropathy hospitalized in the hospital received diet nursing intervention besides routine treatment and nursing, including assessment of patient's conditions, diet instructions to patients and their families and conducting of wardmate get-together. The dieting compliance before nursing intervention was compared with that after intervention. Results The dieting compliance after diet nursing intervention was significantly better than that before intervention (P < 0.0S). Conclusion Diet nursing intervention may enhance the knowledge of diabetic nephropathy patients on alimentary control, improve the compliance of diet therapy, delay the deterioration of diabetes and improve the curative effect.%目的 探讨饮食护理干预对糖尿病肾病患者饮食治疗依从性的效果.方法 选择在本院住院治疗的171例糖尿病肾病患者,在常规治疗和护理的同时,实施饮食护理干预,内容包括评估患者情况、对患者和家属进行饮食指导、举办病友交流会.比较实施饮食护理干预前后患者饮食治疗依从性的差异.结果 实施饮食护理干预后患者饮食治疗依从性优于干预前,干预前后比较,均P< 0.05,差异具有统计学意义.结论 饮食护理干预在提高糖尿病肾病患者对饮食治疗相关知识理解和掌握的同时,提高了患者饮食治疗的依从性,进而延缓疾病的进展和提高治疗效果.

  7. Basal cell carcinomas in elderly patients treated by cryotherapy

    Directory of Open Access Journals (Sweden)

    Chiriac A

    2013-03-01

    Full Text Available Anca Chiriac,1 Doina Mihaila,2 Liliana Foia,3, Caius Solovan4 1Department of Dermatology, Nicolina Medical Center, 2Department of Pathology, St Maria Children's Hospital, 3Surgical Department, Grigore T Popa University of Medicine and Pharmacy, Iaşi, Romania; 4Victor Babe University of Medicine, Timişoara, Romania Abstract: Basal cell carcinoma is a malignant skin tumor with high incidence in our country, especially in rural areas, on sun-exposed skin (particularly on the face in elderly patients. We present three cases of basal cell carcinoma with good results with cryotherapy. This report aims to outline and to prove that in some difficult situations, a simple, inexpensive, easy-to-perform procedure with no contraindications and with minimal side effects (erythema, mild pain can be applied and resolve such cases. Keywords: basal cell carcinoma, cryotherapy

  8. Balancing the Duty to Treat Patients with Ebola Virus Disease with the Risks to Dialysis Personnel

    OpenAIRE

    Evans, Nicholas G.

    2015-01-01

    In 2014, the author was invited to present at the American Society for Nephrology’s annual conference in Philadelphia on the ethics of treating patients with Ebola virus disease. The argument was made that the status of health care workers, including nephrologists, was the dominant ethical standard that generated both the duty to treat and the conflicts between this commitment and other ethical commitments that arise in public health emergencies. Conflicts between duty to treat and personal s...

  9. Prognostic factor and quality of life analysis in 160 patients aged > or =60 years with hematologic neoplasias treated with allogeneic hematopoietic cell transplantation.

    Science.gov (United States)

    Deschler, Barbara; Binek, Kristin; Ihorst, Gabriele; Marks, Reinhard; Wäsch, Ralph; Bertz, Hartmut; Finke, Jürgen

    2010-07-01

    Toxicity-reduced conditioning is a curative treatment option for medically compromised or elderly patients ineligible for myeloablative hematopoietic cell transplantation (HCT). The aim of this study was to detect prognostic factors for overall survival (OS) and to evaluate quality of life (QOL) in a large homogeneous cohort of 160 consecutive patients aged > or =60 years treated with allogeneic HCT. We evaluated age, sex, performance status, comorbidities, pulmonary function, lactic dehydrogenase concentration, type of donor, disease status, CD34(+) cells transplanted, cytomegalovirus status, time from diagnosis to HCT, and the development of acute and chronic graft-versus-host disease (GVHD). All patients who survived for > or =6 months (n = 79) were asked to complete a QOL survey. All patients (median age, 64.7 years; range, 60.1-76 years) received pretransplantation conditioning with fludarabine, BCNU, and melphalan. With a median follow-up of 35 months, the 1-year OS was 62.4% and 3-year OS was 47.4%. Multivariate analysis revealed compromised performance status as the most significant negative prognostic parameter for OS (P < .003), whereas male donor (P = .008) and chronic GVHD (P = .024) were associated with better OS. The 89% of survivors who returned the QOL questionnaire rated their global QOL as good-to-excellent despite impaired functional capabilities and such symptoms as fatigue, dyspnea, and loss of appetite. The main prognostic factor was performance status, not age. Our data suggest that toxicity-reduced conditioning offers a chance for enhanced OS with an adequate QOL.

  10. 40 cases of curative effect observation of acupuncture in treating primary hypertension disease%针刺治疗原发性高血压病40例疗效观察

    Institute of Scientific and Technical Information of China (English)

    康明明; 石学敏

    2013-01-01

    Objective: Observe the influence of acupuncture in treating immediate blood pressure, 8:00, 16:00 blood pressure and 24 hours dynamic blood pressure for 40 cases of patients with primary hypertension disease. Methods: Inserting bilateral Renying (ST-9), Hegu (LI-4), Taichong (LR-3), Quchi (LI -11), Zusanli (ST-36) at daily time of 9:00 and 15:00, to respectively record patients' immediate blood pressure value after inserted 20 minutes, blood pressure value at daily 8:00, 16:00, and 24 hours dynamic blood pressure before and after treatment. 30 days for one period of treatment, 2 days off per week. Making a comparison of immediate blood pressure value, 8:00, 16:00 blood pressure value and two dynamic blood pressure value at 3 days before treatment and the last three days of treatment. Results: The immediate blood pressure value, 8:00, 16:00 blood pressure value and dynamic blood pressure value significantly decreased than acupuncture before, especially the systolic blood pressure, and there was statistically significant difference (P<0.05). Conclusions: Acupuncture could reduce the immediate blood pressure value, mean value of day and night blood pressure, blood pressure load, blood pressure variability and morning blood pressure, effectively improve the rhythm of day and night blood pressure, reverse the non-scoop type blood pressure, which was a kind of safe and effective decompression measure.%目的:观察针刺对40例原发性高血压病即刻血压、8:00、16:00血压及24h动态血压的影响.方法:每日9:00、15:00针刺双侧人迎、合谷、太冲、曲池、足三里,分别记录患者针刺20min后的即刻血压值、每日8:00、16:00的血压值及治疗前后24h动态血压值,30d为1个疗程,疗程中每周休息2d,分别对同一时间段治疗第1-3天和治疗最后3d即刻血压值、8:00、16:00血压值及2次动态血压值进行比较.结果:即刻血压值、8:00、16:00血压值及动态血压值较针刺前均有明显下降,收

  11. The Comparative Study of Venlafaxine Combined with Sulpiride for Treating Patients with Depression%文拉法辛合并舒必利治疗抑郁症的随机对照研究

    Institute of Scientific and Technical Information of China (English)

    尹定富; 曹秀英; 周建文

    2009-01-01

    Objective To observe the curative effect and adverse reaction in the treatment of depres-sion by using venlafaxine combined with sulpiride. Methods The 64 hospital patients with depression were di-vided into two groups randomly. The study group of patients was treated with Venlafaxine Combined with Sulpiride while the controlled group of patients was treated with venlafaxine only. The curative effect and adverse reaction will be measured by Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS). Results The decrease rate in HAMD of the study group33.08% is higher than the controlled groupl0. 64% from the first week and the curative effect87.5% is better than the controlled group68.8% from the fourth week,there are no badly adverse reaction in two groups. Conclusion The treatment with venlafaxine combined with sulpiride can swiftly relieve the depression symptom and the curative effect is better than the treatment with venlafaxine only, and there is no increasing adverse reaction and the patients are willing to follow the course of treatment.%目的 观察文拉法辛合并舒必利治疗抑郁症的疗效和不良反应.方法 对64例住院的抑郁症患者随机分为两组,研究组给予文拉法辛合并舒必利治疗,对照组单用文拉法辛治疗,采用汉密尔顿抑郁量表(HAMD)及副反应量表(TESS)评定疗效和不良反应.结果 研究组第一周HAMD减分率33.08%显著高于对照组10.64%,四周后研究组显效率87.5%优于对照组68.8%,两组均无严重不良反应.结论 文拉法辛合并舒必利能快速缓解抑郁症状,疗效优于单用文拉法辛,不良反应不增加,患者依从性好.

  12. Digital curation theory and practice

    CERN Document Server

    Hedges, Mark

    2016-01-01

    Digital curation is a multi-skilled profession with a key role to play not only in domains traditionally associated with the management of information, such as libraries and archives, but in a broad range of market sectors. Digital information is a defining feature of our age. As individuals we increasingly communicate and record our lives and memories in digital form, whether consciously or as a by-product of broader social, cultural and business activities. Throughout government and industry, there is a pressing need to manage complex information assets and to exploit their social, cultural and commercial value. This book addresses the key strategic, technical and practical issues around digital curation, curatorial practice, and locating the discussions within an appropriate theoretical context.

  13. 晚期三阴性乳腺癌一线治疗GP方案和TAC方案疗效对比%Curative effect contrast of GP scheme and TAC scheme as first-line treatment in treating triple-negative breast cancer

    Institute of Scientific and Technical Information of China (English)

    林顺欢

    2014-01-01

    Objective To compare the effect of GP scheme and TAC scheme as first-line treatment in treating triple-negative breast cancer. Methods 68 patients with triple-negative breast cancer were selected, they were randomly divided in-to the observation group and the control group, 34 cases each. The observation group was given GP scheme combined chemotherapy, while the control group was given TAC scheme combined chemotherapy. The clinical efficacy, adverse reaction and clinical benefit response were compared between the two groups after the treatment. Results The total effective rate was 47.06%in the observation group, no significant difference with the control group (50%), P>0.05. The bone marrow suppression of second degree and third degree and above were 20 cases, 14 cases in the observation group, while they were 13 cases, 21 cases in the control group, the bone marrow toxicity was significant difference between the two groups (P0.05). The clinical benefit response rate of observation group was 55.88%, while 50%in the control group. There was no significant differ-ence between the two groups (P>0.05). Conclusion GP scheme and TAC scheme combined with chemotherapy have good curative effect in treating triple-breast cancer at first-line therapy.%目的:比较GP和TAC两种化疗方案用于晚期三阴性乳腺癌患者一线治疗的临床效果。方法晚期三阴性乳腺癌患者68例,按随机数字表法分为观察组和对照组,各34例。观察组给予GP两药联合化疗,对照组给予TAC三药联合化疗,比较两组患者治疗后的临床疗效、毒副反应发生情况及临床受益反应。结果观察组患者治疗总有效率为47.06%,与对照组患者的50.00%比较无明显差异(P>0.05)。观察组骨髓抑制Ⅱ度及Ⅲ度以上分别为20例、14例,对照组为13例、21例,对照组患者骨髓毒性大于观察组,组间存在显著性差异(P<0.05)。观察组胃肠道反应Ⅱ度以上为19

  14. Gonadal dysfunction in patients treated for metastatic germ-cell tumors.

    Science.gov (United States)

    Leitner, S P; Bosl, G J; Bajorunas, D

    1986-10-01

    The effects of chemotherapy on endocrine function were assessed in 22 previously treated patients with germ-cell tumors and compared with the endocrine function of six previously untreated patients. Baseline and stimulated serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, thyroid-stimulating hormone (TSH), prolactin, and thyroxine (T4) were obtained. Baseline LH levels were elevated in both groups of patients, whereas basal FSH levels were significantly elevated only in treated patients (P less than .001). Following gonadotropin-releasing hormone (GnRH), levels of LH (P = .051) and FSH (P = .003) were greater in treated patients than in untreated control patients. No abnormalities of thyroid function or prolactin responsiveness were observed. Patients younger than 25 years of age at the time of treatment had lower serum levels of LH and FSH following chemotherapy than patients older than 25. Evidence for partial recovery of gonadal function was present with patients treated more than 18 months before study having lower levels of LH and FSH than those patients studied less than 18 months after treatment. These data demonstrate that frequent gonadal dysfunction exists in untreated patients with germ-cell tumors and that chemotherapy induces additional injury to both Leydig cells and the germinal epithelium. Further studies with long-term follow-up are necessary to define the pattern of gonadal recovery and to assess the potential sequelae of endogenous gonadotropin hypersecretion.

  15. Curative effect of wilsonii injecta on severe head injury

    Institute of Scientific and Technical Information of China (English)

    陈礼刚; 曾凡俊; 杨立斌; 柴建康; 李开慧; 卢敏; 匡永勤

    2002-01-01

    Objective: To study the curative effect of wilsoniiinjecta on severe head injury (SHI).Methods: A total of 120 patients with SHI weredivided randomly into 2 groups, the patients treated withconventional methods as Group A (n = 60) and the patientstreated with wilsonii injecta as Group B (n = 60). Thechanges of neural function indexes were evaluated withGlasgow Coma Scale (GCS) before treatment and withGlasgow Outcome Scale ( GOS ) after treatment,simultaneously, the paramneters of hemorrheological indexes(HI), brain electrical activity map ( BEAM ) andtranscranial Doppler sonography (TCD) were observedbefore and after treatment.Results: In Group B, the clinical GCS, the HI, theBEAM and the prognosis GOS were improved much morethan those in Group A. And the TCD parameters in GroupB decreased, which had significant difference comparedwith that in Group A (P <0.01).Conclusions: Wilsonii injecta can rapidly improve theinjured persons' conscious states, the abnormal BEAM and the surviving quality. It suggests that the improvement of the HI is related to the relief of the vasospasm of thearterial blood vessels in the brain, which may be one of theimportant mechanisms of wilsonii injecta in improving theprognosis.

  16. High prevalence of metabolic syndrome features in patients previously treated for nonfunctioning pituitary macroadenoma

    NARCIS (Netherlands)

    Joustra, Sjoerd D.; Claessen, Kim M. J. A.; Dekkers, Olaf M.; van Beek, Andre P.; Wolffenbuttel, Bruce H. R.; Pereira, Alberto M.; Biermasz, Nienke R.

    2014-01-01

    Objective: Patients treated for nonfunctioning pituitary macroadenoma (NFMA) with suprasellar extension show disturbed sleep characteristics, possibly related to hypothalamic dysfunction. In addition to hypopituitarism, both structural hypothalamic damage and sleep restriction per se are associated

  17. Progressive Neurologic Dysfunction in a Psoriasis Patient Treated With Dimethyl Fumarate

    OpenAIRE

    Bartsch, Thorsten; Rempe, Torge; Wrede, Arne; Leypoldt, Frank; Brück, Wolfgang; Adams, Ortwin; Rohr, Axel; Jansen, Olav; Wüthrich, Christian; Deuschl, Günther; Koralnik, Igor J.

    2015-01-01

    Progressive multifocal leukoencephalopathy (PML) has recently been described in psoriasis or multiple sclerosis patients treated with fumaric acid esters (fumarates), who had developed severe and long-standing lymphocytopenia (

  18. [Experience in irradiating with helium-neon lasers to treat patients with relapsing aphthous stomatitis].

    Science.gov (United States)

    Prikuls, V F

    2000-01-01

    Seventy-five patients with relapsing aphthous stomatitis (41 with the fibrinous form, 25 with glandular form, and 9 with necrotic form) were treated using He-Ne laser and a photosensitizer. A good therapeutic effect was attained.

  19. Thirty-five Infantile Purpura Nephritis Patients Treated with Integrated Traditional Chinese and Western Medicine

    Institute of Scientific and Technical Information of China (English)

    ZHENG; Tian-wen

    2001-01-01

    Thirty-five patients of infantile purpura nephritis (IPN) were treated with integrated traditional Chinese and western medicine (TCM-WM) from January 1994 to December 1998, with good efficacy obtained, and following is the report.

  20. Observate the curative effect of 35 cases of type 2 diabetes complicated with cerebral infarction treated by blood house Stasis Decoction%血府逐瘀汤治疗2型糖尿病合并脑梗塞的疗效观察

    Institute of Scientific and Technical Information of China (English)

    栾春霞

    2015-01-01

    ObjectiveTo explore the curative effect of Xuefu Zhuyu Decoction in the treatment of type 2 diabetes complicated with cerebral infarction.MethodsIn our hospital in patients with type 2 diabetes complicated with cerebral infarction and 70 cases as the research object, and were randomly divided into two groups, the control group were given routine treatment, patients in study group were given conventional treatment + Xuefu Zhuyu Decoction treatment, changes in blood glucose and treatment effect before and after treatment in two groups were compared.ResultsThe study group blood sugar improved signiifcantly better than the control group, the difference was statistically signiifcant (P<0.05). Patients in study group was better than that in control group, the difference was statistically signiifcant (P<0.05).ConclusionThe conventional treatment + Xuefu Zhuyu Decoction in the treatment of type 2 diabetes complicated with cerebral infarction curative effect, deifnite curative effect, is worth promoting.%目的:研究探讨血府逐瘀汤治疗2型糖尿病合并脑梗塞的疗效。方法选取我院2型糖尿病合并脑梗塞患者70例作为研究对象,将其随机分为两组,对照组患者给予常规治疗,研究组患者给予常规治疗+血府逐瘀汤治疗,比较两组患者治疗前后的血糖变化及疗效。结果研究组血糖改善明显优于对照组,差异有统计学意义(P<0.05)。研究组患者治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论常规治疗+血府逐瘀汤治疗2型糖尿病合并脑梗塞疗效确切,值得推广。

  1. Reperfusion delay in patients treated with primary percutaneous coronary intervention

    DEFF Research Database (Denmark)

    Schoos, Mikkel M; Sejersten, Maria; Hvelplund, Anders

    2012-01-01

    BACKGROUND: Reperfusion delay in ST-segment elevation myocardial infarction (STEMI) predicts adverse outcome. We evaluated time from alarm call (system delay) and time from first medical contact (PCI-related delay), where fibrinolysis could be initiated, to balloon inflation in a pre-hospital org......BACKGROUND: Reperfusion delay in ST-segment elevation myocardial infarction (STEMI) predicts adverse outcome. We evaluated time from alarm call (system delay) and time from first medical contact (PCI-related delay), where fibrinolysis could be initiated, to balloon inflation in a pre...... identification number to emergency medical services (EMS) and National Board of Health databases in the period of 2005-2008. Patients were stratified according to transfer distances to PPCI into zone 1 (0-25 km), zone 2 (65-100 km) and zone 3 (101-185 km) and according to referral by pre-hospital triage. System...... the local hospital (219 (171-250)). System delay was an independent predictor of mortality (p100 km away and for non-directly referred...

  2. ANALYSIS OF CLINICAL CURATIVE EFFECT OF THE TREATMENT OF PRESSURIZED STEEL SCREWS INTERNAL FIXATION FOR 106 PATIENTS WITH NONUNION OF HUMERUS BACKBONE FRACTURE%加压钢板螺钉内固定用于106例肱骨干骨折术后骨不愈合治疗的临床疗效分析

    Institute of Scientific and Technical Information of China (English)

    吐尔洪江·阿不拉; 吐尔松·热合曼; 邓龙君

    2011-01-01

    [Objective] To explore the clinical curative effect of the treatment of pressurized steel screws internal fixation for patients with nonunion of humerus backbone fracture. [ Methods] 106 patients with brachial backbone fracture nonunion (observation group) were treated by the application of pressurized steel screws internal fixation, analyzed its therapeutic effect, and compared with clinical curative effect of 72 cases (control group) of nun-steel screws adopted the pressure of internal fixation for brachial backbone fracture nonunion. [Results] 106 patients were performed successfully, all were followed up 9 months to 24 months effectively, the average time was 17 months. The line of force was good, 92 cases reached anatomicalreattachment, 14 cases reached the function restoration. The time of X-ray examination for osteoarthritis was 2-11 months, the average was 4.9 months, no one nonunion. 4 patients happened postoperative wound infection, after in time antibiotic treatment, all healed. All patients were without elbows, shoulders, activity function limitation. The excellent and good rates were 100%, and significantly higher than those in the control group. [Conclusion] Pressurized steel screws internal fixation in the treatment of postoperative nonunion after screw humerus fracture has good curative effect, can acquire satisfactory results, and widely used and promoted in clinic.%[目的]探讨加压钢板螺钉内固定在治疗肱骨干骨折术后不愈合方面的临床意义.[方法]对某院经治的106例肱骨干骨折术后不愈合的患者(观察组),应用加压钢板螺钉内固定术,分析其治疗效果,并与72例以往采用非加压钢板螺钉内固定治疗的肱骨干骨折术后不愈合患者(对照组)的临床疗效比较.[结果]106例患者手术均顺利完成,均进行有效随访,随访时闻9~24个月,平均17个月.上肢的力线良好,106例中92例达到了解剖复位,余14例均达到了功能复位.X线检查结

  3. Lymph Node Failure Pattern and Treatment Results of Esophageal Cancer Patients Treated with Definitive Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sun Young; Kwon, Hyoung Cheol; Kim, Jung Soo [Chonbuk National University Hospital, Jeonju (Korea, Republic of); Lee, Heui Kwan [The Catholic University of Korea, Seoul (Korea, Republic of); Kim, Soo Geon [Jesushospital, Jeonju (Korea, Republic of)

    2008-06-15

    We evaluated the failure pattern of the celiac axis, gastric lymph node, and treatment outcome in the upper and mid-esophageal region of cancer patients treated by definitive radiotherapy, except when treating the celiac axis and gastric lymph node for treatment volume, retrospectively. Materials and Methods: The study constituted the evaluation 108 patients with locally advanced esophageal cancer receiving radiotherapy or a combination of radiotherapy and chemotherapy at Chonbuk National University Hospital from January 1986 to December 2006. In total, 82 patients treated by planned radiotherapy, except when treating the celiac axis and gastric lymph node for treatment volume, were analysed retrospectively. The study population consisted of 78 men and 2 women (mean age of 63.2 years). In addition, 51 patients received radiotherapy alone, whereas 31 patients received a combination of radiation therapy and chemotherapy. The primary cancer sites were located in the upper portion (17 patients), and mid portion (65 patients), respectively. Further, the patients were in various clinical stages including T1N0-1M0 (7 patients), T2N0-1M0 (18 patients), T3N0-1M0 (44 patients) and T4N0-1M0 (13 patients). The mean follow up period was 15 months. Results: The various treatment outcomes included complete response (48 patients), partial response (31 patients) and no response (3 patients). The failure patterns of the lymph node were comprised of the regional lymph node (23 patients) and the distance lymph node which included celiac axis and gastric lymph node (13 patients). However, metastasis was not observed in the regional and distant lymph node in 10 patients, whereas 36 patients were not evaluated. Furthermore, of the 13 patients who developed celiac axis and gastric lymph node metastases, 3 were in stage T1N0-1M0 and 10 were in stage T2-4N0-1M0. A complete response appeared in 12 patients, whereas a partial response appeared in 1 patient. The mean survival time of the

  4. Efficacy of abatacept and tocilizumab in patients with rheumatoid arthritis treated in clinical practice

    DEFF Research Database (Denmark)

    Leffers, Henrik Christian; Ostergaard, Mikkel; Glintborg, Bente;

    2011-01-01

    To describe drug survival, disease activity and clinical response in patients with rheumatoid arthritis (RA) treated with abatacept or tocilizumab in routine care, based on prospectively registered observational data from the nationwide Danish DANBIO registry.......To describe drug survival, disease activity and clinical response in patients with rheumatoid arthritis (RA) treated with abatacept or tocilizumab in routine care, based on prospectively registered observational data from the nationwide Danish DANBIO registry....

  5. Early preventive exercises versus usual care does not seem to reduce trismus in patients treated with radiotherapy for cancer in the oral cavity or oropharynx

    DEFF Research Database (Denmark)

    Høgdal, Nina; Juhl, Carsten Bogh; Aadahl, Mette

    2015-01-01

    ABSTRACT Purpose. In head and neck cancer patients undergoing curative radiotherapy, we investigated the benefi ts and harms of an early exercise regime on trismus. Material and methods. Patients with head and neck cancer undergoing radiotherapy were centrally randomised to exercises 5 – 6 times ...

  6. Reduced Acute Bowel Toxicity in Patients Treated With Intensity-Modulated Radiotherapy for Rectal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Samuelian, Jason M. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States); Callister, Matthew D., E-mail: Callister.matthew@mayo.edu [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States); Ashman, Jonathan B. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States); Young-Fadok, Tonia M. [Division of Colorectal Surgery, Mayo Clinic, Scottsdale, AZ (United States); Borad, Mitesh J. [Division of Hematology-Oncology, Mayo Clinic, Scottsdale, AZ (United States); Gunderson, Leonard L. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States)

    2012-04-01

    Purpose: We have previously shown that intensity-modulated radiotherapy (IMRT) can reduce dose to small bowel, bladder, and bone marrow compared with three-field conventional radiotherapy (CRT) technique in the treatment of rectal cancer. The purpose of this study was to review our experience using IMRT to treat rectal cancer and report patient clinical outcomes. Methods and Materials: A retrospective review was conducted of patients with rectal cancer who were treated at Mayo Clinic Arizona with pelvic radiotherapy (RT). Data regarding patient and tumor characteristics, treatment, acute toxicity according to the Common Terminology Criteria for Adverse Events v 3.0, tumor response, and perioperative morbidity were collected. Results: From 2004 to August 2009, 92 consecutive patients were treated. Sixty-one (66%) patients were treated with CRT, and 31 (34%) patients were treated with IMRT. All but 2 patients received concurrent chemotherapy. There was no significant difference in median dose (50.4 Gy, CRT; 50 Gy, IMRT), preoperative vs. postoperative treatment, type of concurrent chemotherapy, or history of previous pelvic RT between the CRT and IMRT patient groups. Patients who received IMRT had significantly less gastrointestinal (GI) toxicity. Sixty-two percent of patients undergoing CRT experienced {>=}Grade 2 acute GI side effects, compared with 32% among IMRT patients (p = 0.006). The reduction in overall GI toxicity was attributable to fewer symptoms from the lower GI tract. Among CRT patients, {>=}Grade 2 diarrhea and enteritis was experienced among 48% and 30% of patients, respectively, compared with 23% (p = 0.02) and 10% (p = 0.015) among IMRT patients. There was no significant difference in hematologic or genitourinary acute toxicity between groups. In addition, pathologic complete response rates and postoperative morbidity between treatment groups did not differ significantly. Conclusions: In the management of rectal cancer, IMRT is associated with a

  7. Outcome of patients treated with automated peritoneal dialysis: Effects of selection of patients

    Directory of Open Access Journals (Sweden)

    Ayman Karkar

    2011-01-01

    Full Text Available To determine the effect of selection of peritoneal dialysis patients who used auto-mated PD (APD as a first renal replacement therapy (RRT option, we studied two groups of adult chronic kidney disease (CKD patients treated with APD over a period of 4 years: group 1 included 30 patients in whom APD was the first choice for RRT and group 2 included 40 patients transferred from failed hemodialysis (HD treatment. Both groups were matched for the original causes of CKD and comorbid conditions. However, group 1 had significantly higher residual renal function (RRF than group 2 [glomerular filtration rate (GFR 11.85 ± 4 mL/min and urine output 995 ± 465 mL/day vs. 3.69 ± 3.7 mL/min and 340 ± 447 mL/day, respectively, P = 0.0001] and Kt/v (2.7 ± 0.7 vs. 1.9 ± 0.4, respectively, P = 0.006. Most of the patients were compliant with their APD prescription, performed ideal PD techniques, achieved adequate dialysis and fluid ultra-filtration, and experienced much less than average infectious and non-infectious complications. However, group 1 achieved better clinical outcome than group 2, including relatively higher sur-vival rate and kidney transplantation, significantly fewer episodes of peritonitis per year (0.09 vs. 0.14, respectively, P = 0.0001, higher serum albumin (2.95 ± 0.3 vs. 2.7 ± 0.27 g/dL, respectively, P = 0.035, hemoglobin (11.5 ± 0.9 vs. 10.6 ± 0.7 g/dL, respectively, P = 0.022 and lower para-thormone levels (283 ± 117 vs. 389 ± 269 pg/mL, respectively, P = 0.02. They also maintained significantly higher total fluid removal compared to group 2 (1120 ± 330 vs. 560 ± 300 mL/day, respectively, P = 0.004, higher RRF (GFR 8 ± 2.6 mL/min vs. 1.8 ± 2.4 mL/min, respectively, P = 0.0001, and urine output (556 ± 447 mL/day vs. 240 ± 347 mL/day, respectively, P = 0.004, and significantly higher Kt/v (2.8 ± 0.7 vs. 1.9 ± 0.4, respectively, P = 0.2. In conclusion, in CKD patients, PD is a viable initial modality of RRT, and with better

  8. CHANGES OF INTERCELLULAR COOPERATION IN PERIPHERAL BLOOD IN TREATED PATIENTS WITH CARDIOLOGIC DISEASES

    Directory of Open Access Journals (Sweden)

    L. N. Korichkina

    2009-01-01

    Full Text Available Aim. To study changes of intercellular cooperation in peripheral blood induced by treatment in patients with arterial hypertension (HT, ischemic heart disease (IHD and chronic heart failure (CHF.Material and methods. 610 patients were involved into the study, including 250 patients with HT of stages I-III (50 untreated patients, 150 patients with IHD and 210 patients with CHF of stages I-III. All patients were treated except 50 hypertensive ones. 80 healthy patients (40 men, 40 women were included into control group. Blood smears of patients were evaluated (Romanovsky's stain. A number of leukocyte, autorosettes and autorosettes with erythrocyte lysis was calculated. The cellular association consisting of a neutrophil, monocyte or eosinocyte with 3 or more erythrocytes skintight to their surface defined as autorosettes. Erythrocytes number and hemoglobin level determined in peripheral blood.Results. Single autorosettes in peripheral blood were observed in patients of control group and in untreated patients with HT. Treated patients with HT, IHD and CHF had increased number of autorossets and autorosettes with erythrocytes lysis. This phenomenon resulted in reduction of erythrocytes number and hemoglobin level in peripheral blood.Conclusion. Treated patients with cardiologic diseases had changes in intercellular cooperation. It should be considered at intensive and long term therapy.

  9. Evaluation of cardiovascular ischemic event rates in dasatinib-treated patients using standardized incidence ratios.

    Science.gov (United States)

    Saglio, Giuseppe; le Coutre, Philipp; Cortes, Jorge; Mayer, Jiří; Rowlings, Philip; Mahon, François-Xavier; Kroog, Glenn; Gooden, Kyna; Subar, Milayna; Shah, Neil P

    2017-08-01

    With high survival rates for chronic myeloid leukemia (CML) patients treated with BCR-ABL1 tyrosine kinase inhibitors (TKIs), emerging consequences, such as arterial ischemic events, require consideration when evaluating treatment options. Cardiovascular ischemic event incidence in clinical trials was evaluated in 2712 dasatinib-treated patients with Philadelphia chromosome-positive (Ph+) leukemias from 11 first- and second-line trials (pooled), newly diagnosed CML patients treated with dasatinib or imatinib (DASISION), and prostate cancer patients treated with dasatinib or placebo plus docetaxel/prednisone (READY). Overall, 2-4% of dasatinib-treated patients had cardiovascular ischemic events. Most dasatinib-treated patients with an event had a history of and/or risk factor for atherosclerosis (pooled 77 with history/risk and event/96 with events; DASISION 8/10; READY 15/18). Most cardiovascular ischemic events occurred within 1 year of initiating dasatinib (pooled 69/96; DASISION 7/10; READY 16/18). Comparison of observed and expected event rates through standardized incidence ratios indicates that dasatinib does not increase risk for cardiovascular ischemic events compared with external reference populations.

  10. Short-Term Outcome of Untreated Versus Treated Asymptomatic Bacteriuria in Renal Transplant Patients.

    Science.gov (United States)

    Arencibia, N; Agüera, M L; Rodelo, C; López, I; Sánchez-Agesta, M; Hurtarte, A; Navarro, M D; Rodríguez-Benot, A

    2016-11-01

    Infection of the urinary tract (UTI) is the most common form of bacterial infection in renal transplant patients, but its management is still controversial. We compared symptomatic and asymptomatic bacteriuria, treated or untreated, during two different months (summer or winter). This longitudinal, prospective study involved routine urine cultures collected during September 2014 or March 2015. Demographic, clinical, and microbiological characteristics from the patients with positive urine cultures were described. The main outcomes were the need of hospitalization, the bacterial clearance, and the selection of the resistant pathogen. From the 538 urine cultures collected, only 61 were positive urine cultures. Twenty were untreated asymptomatic bacteriuria (AB), 28 were treated AB, and 13 were treated symptomatic bacteriuria. The more prevalent micro-organisms were E coli (27%), K pneumoniae (11%), and E faecalis (7%). There were no differences in the demographic, clinical, and microbiological characteristics depending on the month when the urine cultures were collected. Only 10 patients required hospitalization during follow-up, and all of them belonged to the treated group. Bacterial clearance after the treatment occurred in 20 patients of the 41 treated (48.9%) and spontaneously in 14 of the 20 patients untreated (70%). Of the treated patients, 47.6% developed a new resistance to another antibiotic. Only 7.6% of the routine urine cultures on renal transplant were positive. Untreated AB did not require hospitalization, and 70% had spontaneous bacterial clearance. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. 腹腔镜Roux-en-Y胃旁路术治疗2型糖尿病的疗效分析%Curative effect analysis of laparoscopic Roux-en-Y gastric bypass to treat type 2 diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    刘昶; 杨凯; 纪艳超; 王东

    2015-01-01

    Objective To investigate the effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) in treating type 2 diabetes mellitus (T2DM) and the operation essentials of LRYGB.Methods The clinical data of 41 T2DM patients who underwent LRYGB in the Fourth Affiliated Hospital of Harbin Medical University during January 2011 to January 2012 was analyzed. Changes of weight, blood glucose and blood lipid levels before and after operations were compared. The measurement data was compared by Independent-Samplest Test.Results All procedures were successfully without conversion to open operation. No serious postoperative complications were happened. The operative time was (148±21) min. time to ambulation was (3.0±1.4) d, liquid intake at (3.3±1.2) d, and postoperative hospitalization (15.0±4.1) d. Symptoms of T2DM and metabolic disorders were relieved significantly, and the obesity indexes were also decreased significantly(P<0.05).Conclusions LRYGB is effective for obese T2DM which is worthy of clinical application.%目的探讨腹腔镜Roux-en-Y胃旁路术(laparoscopic Roux-en-Y gastric bypass,LRYGB)对2型糖尿病的治疗效果及手术操作要点。方法收集2011年1月至2012年1月在哈尔滨医科大学附属第四医院接受LRYGB的41例2型糖尿病患者的临床资料,对比术前及术后体重、血糖及血脂水平的变化情况,采用两样本t检验进行计量资料的比较。结果所有患者均成功完成手术,无中转开放,无严重术后并发症发生。手术时间(148±21)min,术后(3.0±1.4)d下地活动,术后(3.3±1.2)d恢复流食,术后住院时间为(15.0±4.1)d。所有患者均随访3年,随访期间,糖尿病及代谢异常综合征均明显缓解,各项肥胖指标明显降低,且差异有统计学意义(P<0.05)。结论 LRYGB对合并肥胖的2型糖尿病患者有良好的治疗效果,值得临床广泛开展。

  12. Curative effects of EEG biofeedback on first-episode Schizophrenic patients and its influence on cognitive function%脑电生物反馈治疗首发精神分裂症患者疗效及对认知功能的影响

    Institute of Scientific and Technical Information of China (English)

    孙志勇; 黄河; 张伟

    2015-01-01

    目的:探讨脑电生物反馈治疗对首发精神分裂症患者的疗效及其对认知功能的影响. 方法:将65例首发精神分裂症患者,随机分为研究组和对照组. 对照组患者33例,给予单用药物治疗;研究组患者32例,给予药物联合脑电生物反馈治疗组. 两组患者均治疗6周. 治疗前后,采用阳性与阴性症状量表( PANSS)评定两组患者的临床疗效,采用威斯康星卡片分类测验( WCST)及韦氏成人记忆量表( WMS-RC)的数字广度、数字符号、再生分量表评定两组患者的认知功能. 结果:治疗6周后,两组患者的PANSS及认知功能较治疗前均有改善,但研究组患者的PANSS的阳性症状分、精神病理分及认知功能改善更加明显,与对照组存在差异(P<0. 05). 结论:脑电生物反馈治疗能改善首发精神分裂症患者的认知功能,显著提高临床疗效.%Objective:To explore curative effects of EEG biofeedback onfirst-episode Schizophrenic patients and its influence on cognitive function. Methods:65 first-episode schizophrenicpatients were randomly divided into study group (n=32) and control group (n=33). The control group was treated with single drug for 6 weeks, while the study group was treated with the drug combined with EG biofeedback for 6 weeks. Before and after the treatment, the clinical curative effects were evaluated by positive and negative syndrome scale ( PANSS) , and the cognitive function was assessed by Wisconsin card sorting test ( WCST) , and digit span, digit sym-bol and picture arrangement in Wechsler memory scale-revised China ( WMS-RC) . Results:After 6-week treatment, the PANSS and cognitive function of the two groups were improved. The scores of positive symptom, psychopathy and cognitive function of study group were better than those of control group (P<0. 05). Conclusions:The EEG biofeedback can improve the cognitive function of the first-episode Schizophrenic patients, and significantly improve the clinical

  13. Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study

    OpenAIRE

    Witting, Valerie; Bergis, Dominik; Sadet, Dilek; Badenhoop, Klaus

    2014-01-01

    Background: Diabetes mellitus and thyroid diseases frequently coexist. In order to evaluate how thyroid disorders interfere with glycemic control, we analysed insulin-treated type 2 diabetes patients with thyroid disease. Methods: Diabetes patients (n = 1.957) were retrospectively investigated. We focused on type 2 diabetes patients who had been admitted for insulin-treatment and diagnosed thyroid diseases (n = 328). Patients were divided into three groups according to thyroid disease mani...

  14. Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity

    DEFF Research Database (Denmark)

    Vorum, H; Gram, L; Honoré, B

    1993-01-01

    Binding of valproate and palmitate to serum albumin was studied in 29 valproate-treated epileptic patients. The results were compared with similar observations in a reference group of 43 non valproate-treated individuals. The binding affinity for palmitate was decreased (P ... in increased availability of long-chain fatty acids (P = 0.008) due to competitive valproate binding in the valproate-treated patients. The findings support a hypothesis on the pathogenesis of obesity as a complication of valproate treatment of epilepsy. Udgivelsesdato: 1993-Sep...

  15. Curative Effect of Lengthening and Forward of Achilles Tendon on Treating Spastic Equinus of Children with Cerebral Palsy%跟腱延长前移术治疗脑性瘫痪痉挛型马蹄足的疗效

    Institute of Scientific and Technical Information of China (English)

    张天久; 俞松; 杨小红; 胡月光

    2012-01-01

    目的 评价跟腱延长前移术治疗儿童脑性瘫痪痉挛型马蹄足的疗效.方法 收集1998年5月- 2011年6月应用跟腱延长前移术治疗脑性瘫痪痉挛型马蹄足儿童53例85足.男28例45足,女25例40足;年龄2.5 ~14.0岁,平均6.8岁.痉挛程度按Ashworth 5级法评定:3级12足,4级38足,5级35足.患儿均能行走,智力发育及下肢肌力基本正常,伴不同程度肌张力增高,腱反射亢进,踝阵挛和Babinski征阳性,无明显内翻、外翻及平足畸形,X线片未提示明显骨性畸形.合并双髋内收畸形5例,双膝屈曲畸形2例,均在术前或同期行手术矫正.结果 患儿均获随访,随访时间0.5~11.2a,平均2.3a.1例于术后2周出现切口裂开、跟腱断裂,再次行跟腱吻合术,术后恢复良好;患儿术后均未发现小腿三头肌肌力较术前下降.53例85足均获满意疗效,优55足,良30足,优良率达100%.结论 跟腱延长前移术利用生物力学原理,在跟腱延长的基础上将跟腱止点前移至跟距关节后缘,缩短了跟腱至踝关节的力臂,平衡了踝关节背伸与跖屈肌肌力,远期效果良好,是儿童脑性瘫痪痉挛型马蹄足较好的治疗方法.%Objective To evaluate curative effect of lengthening and forward of achilles tendon on treating spastic equinus of children with cerebral palsy. Methods Fifty -three patients (85 feet) with spastic equinus caused by cerebral palsy in children, including 28 male (45 feet)and 25 female (40 feet) .were treated with lengthening and forward of achilles tendon from May 1998 to Jun. 2011. The ages of the patients ranged from 2.5 to 14.0 years. According to the Ashworth method for the evaluation of spastieity:12 feet belonged to level 3,38 feet level 4,and 35 feet level 5. All patients were able to walk,had normal intelligence and muscle strength of lower limbs,varying degrees of muscle tension,tendon reflexes hyperfunction, ankle clonus and Babinski sign positive,had not significant bone

  16. Curative effect of primary liver cancer treated by SBRT synchronous DC - CIK biological treatment%SBRT同步DC-CIK生物治疗对中晚期原发性肝癌的疗效观察

    Institute of Scientific and Technical Information of China (English)

    杜海峰; 魏长宏; 王作志; 卞晓山; 傅振强

    2016-01-01

    109 ,2 ~ 6 courses. During treat-ment,avoiding the use of any drug. Results:After the treatment in 2 ~ 3 months,6 cases were CR(14. 3% ),31 cases were PR(73. 8),5 cases were NC(11. 9% ),the total efficiency 88. 1% . Epigastric discomfort,abdominal pain and other clinical symptoms improve ment efficiency was 76% ,patients with ascites remission rate was 75% . Conclusion:Advanced SBRT synchronous DC - CIK biological treatment on primary liver cancer,can significantly improve the quality of life and the toxicity can be tolerated,is a safe and reliable treatment.

  17. Eight-year survival after advanced gastric cancer treated with S-1 followed by surgery

    Institute of Scientific and Technical Information of China (English)

    Susumu; Hijioka; Keisho; Chin; Yasuyuki; Seto; Noriko; Yamamoto; Kiyohiko; Hatake

    2010-01-01

    We report a case of advanced gastric cancer, with cervical, axillary, and abdominal paraaortic lymph node metastases, that was successfully treated with chemotherapy and surgery. The disease was initially considered unresectable, and the patient was treated with orally administered S-1. Chemotherapy was effective, and all lymph node metastases disappeared after 6 courses. After 27 mo of chemotherapy, the patient underwent curative surgery, with subtotal gastrectomy and lymph node dissection. Histopathologic...

  18. Increasing infection rate in multiple implanted pulse generator changes in movement disorder patients treated with deep brain stimulation

    DEFF Research Database (Denmark)

    Thrane, Jens F; Sunde, Niels A; Bergholt, Bo

    2014-01-01

    Increasing infection rate in multiple implanted pulse generator changes in movement disorder patients treated with deep brain stimulation......Increasing infection rate in multiple implanted pulse generator changes in movement disorder patients treated with deep brain stimulation...

  19. Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP

    Energy Technology Data Exchange (ETDEWEB)

    Albano, Domenico; La Grutta, Ludovico; Grassedonio, Emanuele; Brancatelli, Giuseppe; Lagalla, Roberto; Midiri, Massimo; Galia, Massimo [University of Palermo, Department of Radiology, DIBIMED, Palermo (Italy); Patti, Caterina; Mule, Antonino [Azienda Ospedali Riuniti Villa Sofia-Cervello, Department of Hematology I, Palermo (Italy)

    2017-05-15

    The purpose of our retrospective review of prospectively acquired Whole Body Magnetic Resonance (WB-MRI) scans was to assess the incidence of osteonecrosis in patients who received different chemotherapies. We evaluated the WB-MRI scans performed on 42 patients with Hodgkin Lymphoma treated by three chemotherapy regimens (6ABVD, 2ABVD + 4BEACOPP, 2ABVD + 8BEACOPP), excluding patients with the main risk factors for osteonecrosis. Six out of seven patients (86 %) who received eight BEACOPP and one out of five patients (20 %) treated by four BEACOPP presented osteonecrosis, with a statistically significant difference of frequency between the two groups of patients (p < 0.05); no injury has been reported in patients treated by only ABVD. Among a total of 48 osteonecrotic lesions observed, 48 % were detected in the knee; multifocal osteonecrosis were detected in six out of seven patients (86 %). The development of osteonecrosis is strictly related to the chemotherapy protocol adopted and the number of cycles received, with a strong correlation between the dose of corticosteroids included in the BEACOPP scheme and this complication. WB-MRI can be considered as a helpful tool that allows detecting earlier osteonecrotic lesions in patients treated with corticosteroids. (orig.)

  20. Electrophysiological correlates of information processing in breast-cancer patients treated with adjuvant chemotherapy.

    Science.gov (United States)

    Kreukels, Baudewijntje P C; Schagen, Sanne B; Ridderinkhof, K Richard; Boogerd, Willem; Hamburger, Hans L; van Dam, Frits S A M

    2005-11-01

    Cognitive deficits are found in a number of breast-cancer patients who have undergone adjuvant (Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF)) chemotherapy, but the underlying mechanisms are still unclear. The objective of this study is to investigate information processing in these patients with concurrent registration of brain activity. Twenty-six breast-cancer patients treated with adjuvant CMF chemotherapy and a control group of 23 stage I breast-cancer patients not treated with chemotherapy were examined. Mean time since treatment for the CMF patients was 5.1 years after the last CMF course, and for the control patients 3.6 years after termination of radiotherapy. An information processing task was administered with concurrent EEG registration. Reaction times and the amplitudes and latencies of an Event Related Potential component (P3) in different task conditions related to input, central, and output processing of information were studied. Significant differences in latency and amplitude of the P3 component were found between the treatment groups with an earlier and reduced P3 in the chemotherapy group. Patients treated with chemotherapy had longer reaction times (although not significantly different) than the control group on all task conditions. Our data provide further evidence for long-term neurocognitive problems in breast-cancer patients treated with adjuvant (CMF) chemotherapy and offer new information regarding abnormalities in brain functioning in these patients.

  1. Serum Leptin Levels in Epileptic Patients Treated with Topiramate and Valproic Acid

    Directory of Open Access Journals (Sweden)

    İrem Fatma Uludağ

    2011-03-01

    Full Text Available OBJECTIVE: Leptin is considered to be a signal factor that regulates body weight and energy expenditure, and there is a strong correlation between serum leptin concentrations, body mass index, and body fat mass in humans. Our aim in this study was to evaluate the role of leptin in valproic acid (VPA and topiramate (TPM related weight changes in epileptic patients. METHODS: Body mass index is calculated and serum leptin and insulin levels are measured in 56 patients with epilepsy (40 patients taking VPA and 16 patients taking VPA and TPM and in 40 healty control subjects. RESULTS: Obesity was seen in 21 patients (52.5% in VPA treated group, in 15 patients (37.5% in the control group and in only one male (6.3% in VPA and TPM treated group. Body mass index was lower in the group treated with VPA and TPM (p<0.001. Serum leptin concentrations were correlated with the body mass index (r=0.49, p<0.001 and were significantly higher in obese subjects (p<0.001 and in women (p<0.001. Serum leptin levels were significantly lower in patients treated with VPA and TPM (p<0.05. CONCLUSION: High levels of serum leptin in patients taking VPA and significantly low levels of serum leptin in patients taking VPA and TPM in our study are in agreement with the hypotheses that weight changes induced with VPA and TPM are related with the alterations in serum leptin levels.

  2. Interpretation and Prognostic Value of Positron Emission Tomography-Computed Tomography After Induction Chemotherapy With or Without Radiation in IIIA-N2 Non-small Cell Lung Cancer Patients Who Receive Curative Surgery.

    Science.gov (United States)

    Kim, Sung Hwan; Lee, Jong Hoon; Lee, Guk Jin; Jeong, Songmi; Kwak, Yoo-Kang; Kim, Hoon-Kyo; Cho, Deog Gon; Park, Young Ha; Yu, Mina; Yoon, Sei Chul

    2015-06-01

    We evaluate the correlation of clinical staging on positron emission tomography-computed tomography (PET-CT) and pathologic staging and the prognostic value of PET-CT after induction chemotherapy in patients with locally advanced nonsmall cell lung cancer (NSCLC). We analyzed 42 cases of clinical stage IIIA-N2 NSCLC who receive 2 to 4 cycles of preoperative chemotherapy with or without radiation followed by curative resection. The maximum standard uptake value (SUVmax) of the suspected lesion on PET-CT was recorded. PET-CT findings after induction chemotherapy were compared with those of initial PET-CT and pathology after surgery. The accuracy of PET-CT in restaging of the primary tumor after induction chemotherapy was 50.0%. Eighteen (42.8%) of 42 patients were underestimated ycT stage, and 3 (7.1%) of 42 patients was overestimated ycT stage by PET-CT scan. The accuracy of PET-CT in restaging of the nodal disease was 71.4%. Six (14.3%) of 42 patients were underestimated ycN stage, and 6 (14.3%) of 42 patients were overestimated ycN stage as compared with pathologic staging. The 2-year overall survival (OS) and relapse-free survival (RFS) rate were 68.5% and 40.9%, respectively. Complete responders (ycT0N0M0) on PET-CT after induction chemotherapy had a significantly longer RFS time than did incomplete responders (28.3 vs 9.1 months, P = 0.021). Complete response on PET-CT after induction chemotherapy with or without radiation was a good prognosticator for RFS in stage IIIA-N2 NSCLC patients who received surgery. However, response evaluation on PET-CT after induction chemotherapy should be interpreted with caution due to its unacceptable accuracy.

  3. 油樟叶挥发油水乳剂对家兔自然感染皮肤真菌病的疗效观察%Curative effect of the emulsion in water from volatile oil of Cinnamomum longepaniculatum leaves on treating rabbits with dermatophytosis

    Institute of Scientific and Technical Information of China (English)

    范静; 汪开毓; 殷中琼; 魏琴; 周黎军; 贾仁勇; 耿毅; 杜永华

    2012-01-01

    从患皮肤真菌病家兔的皮屑、被毛中分离病原真菌,并进行病原鉴定;分别用5、10、30mL/L油樟叶挥发油水乳剂通过皮肤涂擦法进行治疗试验,以观察油樟叶挥发油水乳剂对家兔皮肤真菌病的疗效。结果显示,分离得到的2种病原真菌经培养特性、菌落性状、菌丝形态和孢子性状特征等鉴定,为须毛癣菌和犬小孢子菌;3种剂量组的油樟叶挥发油水乳剂对家兔皮肤真菌病均有较好的疗效,其中以10mL/L油樟叶挥发油水乳剂对于家兔自然感染皮肤真菌病的疗效最好。试验表明油樟叶挥发油水乳剂对兔自然感染的皮肤真菌病具有一定的疗效。%The pathogenic microorganisms were isolated from scurf and coat of diseased rabbits.After identification of the pathogenic microorganism,the rabbits with dermatophytosis were treated with three different dosages of emulsion(5 mL/L,10 mL/L,30 mL/L) in water from volatile oil of Cinnamomum longepaniculatum leaves by skin iatraliptics to observe the curative effect of the emulsion on treating rabbits with dermatophytosis.Result showed that two kinds of pathogenic microorganism were isolated,which were identified as Microsporum canis and Trichophyton mentagrophytes,according to colony morphology,hypha and spore morphology,culture character,and the pathogenic experiments of the bacteria isolates.All of the three different dosages of emulsion had good antifungal effects and the emulsion containing 10 mL/L volatile oil showed a preferable curative effect on treating rabbits with dermatophytosis.Therefore,the emulsion in water from volatile oil of C.longepaniculatum leaves had good antifungal effect against dermatophytosis.

  4. Curative effect observation on treating cervicalspondylotic radiculopathy with neck pain particles combined with traction%颈痛颗粒配合牵引治疗神经根型颈椎病的疗效观察

    Institute of Scientific and Technical Information of China (English)

    李托

    2014-01-01

    Objection: To discussion the clinical effects on treating cervicalspondylotic radiculopathy with neck pain particles combined with traction. Methods: The clinical data of 87 cases admitted during 2011 June to 2012 December as the object of study in my department, were randomly divided into treated group 46 cases and control group of 41 cases, the control group was treated by cervical traction, the treated group was treated by neck pain particles combined with traction. Analysis of treatment results after 4 weeks treatment. Results: The treated group cure rate is about 28.3%, the total efficiency of 89.1%;control group, the cure rate is about 14.6%, the total efficiency is about 68.3%, the treated group was significantly better than the control group, the difference was statistically significant (P<0.05). Conclusion: Treating cervicalspondylotic radiculopathy with neck pain particles combined with traction have a significant treatment effect, is worthy of clinical popularization and application.%目的:研究颈痛颗粒配合牵引治疗神经根型颈椎病的临床治疗效果。方法:观察我科在2011年6月-2012年12月期间收治的87例神经根型颈椎病患者的临床资料作为研究对象,按照随机分组的原则将之分为治疗组46例和对照组41例,其中对照组采用单纯颈椎牵引进行治疗,治疗组则在牵引基础上加用颈痛颗粒进行治疗,治疗4周后统计两组患者的治疗结果并进行分析。结果:治疗组患者的治愈率约为28.3%,总有效率约为89.1%;对照组患者的治愈率约为14.6%,总有效率约为68.3%,治疗组明显优于对照组,差异具有统计学意义(P<0.05)。结论:颈痛颗粒配合颈椎牵引用于治疗神经根型颈椎病的临床效果显著,较单纯采用牵引进行治疗有着明显的优势,值得在临床上推广和应用。

  5. Curative Effect Comparison of Hemodialysis Therapy in Diabetic Nephropathy and Nondiabetic Nephropathy Patients%糖尿病肾病与非糖尿病肾病患者维持性血液透析疗效比较

    Institute of Scientific and Technical Information of China (English)

    吴小群

    2012-01-01

    Objective To explore the clinical curative effect of hemodialysis in diabetes nephrosis and nondiabetic nephropathy patients, and the measures of reducing complications, improve the life quality and long-tenn survival of patients. Methods A retrospective study was done from January 2007 to January 2008 , 52 patients with diabetes nephrosis were selected and 50 patients without diabetes nephrosis were selected as control group. The cause of death, complications and survival of the two groups of patients were compared. Results 3 years later,there were 28 survivals^ 53. 85% )in the diabetic nephropathy group and there were 39 survivals( 78% )in the control group. The 3-year survival rate in the diabetes nephrosis group was lower than that in the control group, the difference was statistically significant( P < 0. 05 ). In the diabetes nephrosis group,11 case( 45. 83% )died of infection;5 cases( 20. 83% )died of cardiovascular disease;3 patients ( 12.5% )died of cerehrovascular diseases; 5 cases( 20.83% )died of other reasons. Conclusion The curative effect of hemodialysis in diabetic nephropathy patients is worse than that in nondiabetic nephropathy patients. The diabetes nephrosis patients should begin hemodialysis as early as possible, during treatment active control of blood pressure, lipids, and sugar, and improvement of the nutritional status and anemia of the patients, should be done,which can improve the clinical symptoms and the survival rate.%目的 分析研究血液透析对糖尿病肾病与非糖尿病肾病的临床疗效,以减少患者的并发症,提高其生活质量和长期的生存率.方法 回顾2007年1月至2008年1月在我院治疗的52例糖尿病肾病患者的临床资料,选取同期收治的50例非糖尿病肾病患者的临床资料作为对照.比较两组患者的死亡原因、并发症以及生存率.结果 3年后,糖尿病肾病组患者生存28例,生存率为53.85%;对照组患者生存39例,生存率为78%,

  6. 硝普钠联合多巴胺治疗急性心力衰竭的临床观察%Curative Effect of Sodium Nitroprusside Combined Dopamine in Treatment of Patients With Acute Heart Failure

    Institute of Scientific and Technical Information of China (English)

    王岚

    2016-01-01

    目的:观察硝普钠联合多巴胺治疗急性心力衰竭患者的效果。方法随机将110例急性心力衰竭患者平均分为2组,对照组行硝普钠治疗,观察组在对照组的基础上联合多巴胺治疗。结果观察组总有效率、生理指标等均优于对照组(P<0.05)。结论硝普钠联合多巴胺治疗急性心力衰竭效果理想。%Objective To investigate the curative effect of sodium nitroprusside combined dopamine in the treatment of patients with acute heart failure. Methods We divided 110 patients into two groups,the control group used sodium nitroprusside treatment,and observation group used dopamine on the basis of the control group. Results The total effective rate and physiological indexes of the observation group were significantly better than control group(P<0.05). Conclusion The effect of sodium nitroprusside combined dopamine in the treatment of acute heart failure is ideal.

  7. Sexual functioning in testosterone-supplemented patients treated for bilateral testicular cancer

    NARCIS (Netherlands)

    van Basten, Johannes; vanDriel, MF; Jonker, G; Sleijfer, DT; Schraffordt Koops, Heimen; van de Wiel, HBM; Hoekstra, HJ

    1997-01-01

    Objective To determine the effects of intramuscular injections with testosterone (Sustanon(R)) on sex-hormone levels, sexual functioning and general wellbeing in patients treated with orchidectomy for bilateral testicular cancer. Patients and methods The study comprised seven men (median age 38 year

  8. Acute exercise in treated phenylketonuria patients: Physical activity and biochemical response

    Directory of Open Access Journals (Sweden)

    Priscila Nicolao Mazzola

    2015-12-01

    Conclusions: Acute aerobic exercise followed by a Phe-restricted breakfast did not change Phe concentrations in treated phenylketonuria patients, but it was associated with decreased Phe/Tyr only in controls. Further studies are necessary to confirm our results in a higher number of patients.

  9. Anal carcinoma - Survival and recurrence in a large cohort of patients treated according to Nordic guidelines

    DEFF Research Database (Denmark)

    Leon, Otilia; Guren, Marianne; Hagberg, Oskar

    2014-01-01

    OBJECTIVE: To evaluate treatment outcome in a large population-based cohort of patients with anal cancer treated according to Nordic guidelines. MATERIAL: Clinical data were collected on 1266 patients with anal squamous cell carcinoma diagnosed from 2000 to 2007 in Sweden, Norway and Denmark. 886...

  10. Clinical impact of microscopic extrathyroidal extension in patients with papillary thyroid microcarcinoma treated with hemithyroidectomy.

    Science.gov (United States)

    Ahn, D; Sohn, J H; Jeon, J H; Jeong, J Y

    2014-02-01

    Pathologically confirmed microscopic extrathyroidal extension (ETE) is often identified after hemithyroidectomy in patients with papillary thyroid microcarcinoma (PTMC). Without the presence of microscopic ETE, these patients would be optimal candidates for hemithyroidectomy. The present study aimed at evaluating the clinical impact of microscopic ETE on the recurrence of PTMC treated with hemithyroidectomy. We compared the clinicopathological characteristics and 5-year outcomes for 262 PTMC patients without ETE and 86 with microscopic ETE who were treated with hemithyroidectomy between January 2004 and December 2010. The mean tumour size was larger (0.67 vs. 0.54 cm, p microscopic ETE as compared with patients without ETE. Occult multifocal disease was more frequent in patients with microscopic ETE than in those without ETE (14.0 vs. 6.5 %, p = 0.030). However, the recurrence rate was not different between the two groups during the mean 55.8-month follow-up period. In addition, univariate and multivariate analyses revealed no meaningful association between recurrence and microscopic ETE in patients with PTMC treated with hemithyroidectomy. Although microscopic ETE was associated with large tumour size and multifocal disease, its clinical impact on disease recurrence was not significant in PTMC patients treated with hemithyroidectomy. Therefore, microscopic ETE identified after hemithyroidectomy would not be an absolute indication for completion thyroidectomy in patients with PTMC.

  11. Outcomes of Patients With Burkitt Lymphoma Older Than Age 40 Treated With Intensive Chemotherapeutic Regimens

    NARCIS (Netherlands)

    Kelly, Jennifer L.; Toothaker, Stephen R.; Ciminello, Lauren; Hoelzer, Dieter; Holte, Harald; LaCasce, Ann S.; Mead, Graham; Thomas, Deborah; Van Imhoff, Gustaaf W.; Kahl, Brad S.; Cheson, Bruce D.; Magrath, Ian T.; Fisher, Richard I.; Friedberg, Jonathan W.

    2009-01-01

    Burkitt lymphoma is a highly curable disorder when treated with modern intensive chemotherapy regimens. The majority of adult patients with Burkitt lymphoma in the United States are over age 40 years. Older patients have historically been underrepresented in published clinical trials of modern inten

  12. Randomized controlled trial of modified Banxia Houpo decoction in treating functional dyspepsia patients with psychological factors

    Institute of Scientific and Technical Information of China (English)

    肖琳

    2013-01-01

    Objective To observe the therapeutic effect of Modified Banxia Houpo Decoction(MBHD)in treating patients with functional dyspepsia(FD)accompanied with psychological factors,and to compare it with Domperidone,Neurostan,and Domperidone+Neurostan.Methods Recruited were 89 FD patients

  13. Education about treating patients with HIV infections/AIDS: the student perspective.

    Science.gov (United States)

    Seacat, Jason P; Inglehart, Marita Rohr

    2003-06-01

    This study investigated dental and dental hygiene students' a) perceptions of their education about treating patients with HIV infections/AIDS, b) knowledge of universal precautions, c) attitudes towards treating these patients and patients perceived to be at risk for HIV infections, and d) evaluations of potential curricular activities such as discussion groups with HIV-infected patients. Data were collected with self-administered questionnaires from 315 dental and 89 dental hygiene students. On average, dental students reported having learned about this topic in fever courses than dental hygiene students. However, dental students answered significantly more knowledge questions about universal precautions correctly than did dental hygiene students. This knowledge increased over the program course. Male students had significantly stronger negative attitudes towards patients at risk for or with HIV infections/AIDS than female students. Overall, dental and dental hygiene students responded positively to the suggested methods for including more material about patients with HIV infections/AIDS such as case studies, discussion groups, and closely supervised clinical experiences. This study shows that dental and dental hygiene students are interested in learning more about treating patients with HIV infections/AIDS. It also adds information to previous research on factors involved in the dental healthcare providers' decisions to treat patients at risk for or with HIV infections/AIDS. The implications of these findings for curriculum development efforts are discussed.

  14. A Theoretical Model for Understanding Dentists' Behavior in Treating