Sample records for cultural formulation approach

  1. A Cultural Formulation Approach to Career Assessment and Career Counseling with Asian American Clients (United States)

    Leong, Frederick T. L.; Hardin, Erin E.; Gupta, Arpana


    Using the cultural formulations approach to career assessment and career counseling, the current article applies it specifically to Asian American clients. The approach is illustrated by using the "Diagnostic and Statistical Manual of Mental Disorders" fourth edition ("DSM-IV") Outline for Cultural Formulations that consists of the following five…

  2. An exact approach for aggregated formulations

    DEFF Research Database (Denmark)

    Gamst, Mette; Spoorendonk, Simon; Røpke, Stefan

    Aggregating formulations is a powerful approach for problems to take on tractable forms. Aggregation may lead to loss of information, i.e. the aggregated formulation may be an approximation of the original problem. In branch-and-bound context, aggregation can also complicate branching, e.g. when...... optimality cannot be guaranteed by branching on aggregated variables. We present a generic exact solution method to remedy the drawbacks of aggregation. It combines the original and aggregated formulations and applies Benders' decomposition. We apply the method to the Split Delivery Vehicle Routing Problem....

  3. Considering the cultural context in psychopathology formulations

    Directory of Open Access Journals (Sweden)

    Junaid Hassim


    Full Text Available Background. Mental health research appears to be continually transforming. Recent literature reflects a greater appreciation for the ways in which pathoplastic features of culture modulate emotional regulation. This article introduces those aspects of the literature which explore the (reconsideration of culture as a dynamic and essential construct in the clinical formulation of psychopathology. Objectives. The study aims to review literature that focuses on the dynamic influence of culture in psychopathology. Furthermore, the researchers aim to present a view on the ways in which culture appeared to shape the topography of psychopathology nosology. Method. A literature review of 31 sources. Results. The review indicated that 29 literature sources were conceptual in design, suggesting a great need for more empirical research. This section also explored themes identified during the literature review. The literature was tabulated according to features and emerging themes. Three major themes were identified and included: the cultural context; the evolving definitions of culture; and culture and psychopathology. Conclusion/discussion. An analysis of the themes was offered. The authors concluded by highlighting the significance of the literature at present. Areas of particular interest suggested that health and behaviour are dependent, at least in part, on culture; psychopathology may also be appreciated as a social construct; culture influences psychopathology regardless of the aetiology; diagnostic classes do not adequately consider operational definitions; and a greater focus on hermeneutic perceptivity in appreciating cultural dynamics in psychopathology will benefit clinical assessment.

  4. An exact approach for aggregated formulations

    DEFF Research Database (Denmark)

    Gamst, Mette; Spoorendonk, Simon

    Aggregating formulations is a powerful approach for transforming problems into taking more tractable forms. Aggregated formulations can, though, have drawbacks: some information may get lost in the aggregation and { put in a branch-and-bound context { branching may become very di_cult and even....... The paper includes general considerations on types of problems for which the method is of particular interest. Furthermore, we prove the correctness of the procedure and consider how to include extensions such as cutting planes and advanced branching strategies....

  5. Loss, Psychosis, and Chronic Suicidality in a Korean American Immigrant Man: Integration of Cultural Formulation Model and Multicultural Case Conceptualization (United States)

    Shea, Munyi; Yang, Lawrence H.; Leong, Frederick T. L.


    Culture shapes the nature, experience, and expression of psychopathology and help-seeking behavior across ethnically diverse groups. Although the study of psychopathology among Asian Americans has advanced, clinicians remain in need of culturally appropriate tools for the assessment and diagnosis of severe mental disorders including psychotic symptoms among Asian Americans. In this article, we present a brief overview of two culturally relevant conceptual tools: a) the Cultural Formulation Model, and b) the Multicultural Case Conceptualization approach. We use a case scenario to illustrate the integration of these two approaches in providing culturally responsive clinical conceptualization, assessment and treatment of a Korean American immigrant suffering from prominent psychiatric symptoms. We intend this discussion to engender further empirical work to advance our knowledge of the manifestation and experience of severe mental illness including psychotic disorders among Asian Americans, and contribute to culturally competent prevention and intervention of chronic and persistent mental illness within this group. PMID:21603157

  6. Enabling Strategy Formulation by ICT: A Viable Systems Approach

    NARCIS (Netherlands)

    Vriens, D.J.; Achterbergh, J.M.I.M.; Vriens, D.J.


    In this chapter the role of ICT for competitive intelligence is approached from the perspective of strategy formulation. The authors hold the view that competitive intelligence can be seen as knowledge necessary for the process of strategy formulation. To determine the role of ICT, it is proposed to

  7. Induction of osteogenic differentiation of stem cells via a lyophilized microRNA reverse transfection formulation on a tissue culture plate

    Directory of Open Access Journals (Sweden)

    Wu K


    Full Text Available Kaimin Wu,1,* Jie Xu,2,* Mengyuan Liu,1 Wen Song,1 Jun Yan,1 Shan Gao,3 Lingzhou Zhao,2 Yumei Zhang1 1Department of Prosthetic Dentistry, 2Department of Periodontology and Oral Medicine, School of Stomatology, The Fourth Military Medical University, Xi’an, People’s Republic of China; 3The Interdisciplinary Nanoscience Center and Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark; School of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China*Both authors contributed equally to this workAbstract: MicroRNA (miRNA regulation is a novel approach to manipulating the fate of mesenchymal stem cells, but an easy, safe, and highly efficient method of transfection is required. In this study, we developed an miRNA reverse transfection formulation by lyophilizing Lipofectamine 2000-miRNA lipoplexes on a tissue culture plate. The lipoplexes can be immobilized on a tissue culture plate with an intact pseudospherical structure and lyophilization without any lyoprotectant. In this study, reverse transfection resulted in highly efficient cellular uptake of miRNA and enabled significant manipulation of the intracellular target miRNA level. Reverse transfection formulations containing Lipofectamine 2000 1 µL per well generated much higher transfection efficiency without obvious cytotoxicity compared with conventional and other transfection methods. Further, the transfection efficiency of the reverse transfection formulations did not deteriorate during 90 days of storage at 4°C and -20°C. We then assessed the efficiency of the miRNA reverse transfection formulation in promoting osteogenic differentiation of mesenchymal stem cells. We found that transfection with anti-miR-138 and miR-148b was efficient for enhancing osteogenic differentiation, as indicated by enhanced osteogenesis-related gene expression, amount of alkaline phosphatase present, production of collagen, and matrix mineralization. Overall

  8. A Systematic Approach to Strategy Formulation for Medium-Sized Shipyards


    Ma'ruf, Buana


    A more comprehensive strategy formulation has an important role for sustainable competitive advantage of the shipbuilding companies in the global market. The nature of shipbuilding industry differs from general industry, therefore a strategy formulation model should be developed based on its own characteristics and business environment. This paper presents a proposed strategy formulation model for medium-sized shipyards both in business and corporate levels. A new approach was developed based...

  9. Simultaneously Exploiting Two Formulations: an Exact Benders Decomposition Approach

    DEFF Research Database (Denmark)

    Lusby, Richard Martin; Gamst, Mette; Spoorendonk, Simon

    When modelling a given problem using linear programming techniques several possibilities often exist, and each results in a different mathematical formulation of the problem. Usually, advantages and disadvantages can be identified in any single formulation. In this paper we consider mixed integer...... to the standard branch-and-price approach from the literature, the method shows promising performance and appears to be an attractive alternative....

  10. New approach for dry formulation techniques for rhizobacteria (United States)

    Elchin, A. A.; Mashinistova, A. V.; Gorbunova, N. V.; Muratov, V. S.; Kydralieva, K. A.; Jorobekova, Sh. J.


    Two beneficial Pseudomonas isolates selected from rhizosphere of abundant weed - couch-grass Elytrigia repens L. Nevski have been found to have biocontrol activity. An adequate biocontrol effect requires high yield and long stability of the bacterial preparation [1], which could be achieved by an effective and stable formulation. This study was aimed to test various approaches to dry formulation techniques for Pseudomonas- based preparations. To reach this goal, two drying formulation techniques have been tested: the first one, spray drying and the second, low-temperature contact-convective drying in fluidized bed. The optimal temperature parameters for each technique were estimated. Main merits of the selected approach to dry technique are high yield, moderate specific energy expenditures per 1 kg of evaporated moisture, minimal time of contact of the drying product with drying agent. The technological process for dry formulation included the following stages: the obtaining of cell liquids, the low-temperature concentrating and the subsequent drying of a concentrate. The preliminary technological stages consist in cultivation of the rhizobacteria cultures and concentrating the cell liquids. The following requirements for cultivation regime in laboratory conditions were proposed: optimal temperatures are 26-28°С in 3 days, concentration of viable cells in cell liquid makes 1010-1011 cell/g of absolutely dry substance (ADS). For concentrating the cell liquids the method of a vacuum evaporation, which preserves both rhizobacteria cells and the secondary metabolites of cell liquid, has been used. The process of concentrating was conducted at the minimum possible temperature, i.e. not above 30-33°С. In this case the concentration of viable cells has decreased up to 109-1010 cell/g of ADS. For spray drying the laboratory up-dated drier BUCHI 190, intended for the drying of thermolabile products, was used. The temperatures of an in- and outcoming air did not exceed

  11. Untargeted LC-MS/MS Profiling of Cell Culture Media Formulations for Evaluation of High Temperature Short Time Treatment Effects. (United States)

    Floris, Patrick; McGillicuddy, Nicola; Albrecht, Simone; Morrissey, Brian; Kaisermayer, Christian; Lindeberg, Anna; Bones, Jonathan


    An untargeted LC-MS/MS platform was implemented for monitoring variations in CHO cell culture media upon exposure to high temperature short time (HTST) treatment, a commonly used viral clearance upstream strategy. Chemically defined (CD) and hydrolysate-supplemented media formulations were not visibly altered by the treatment. The absence of solute precipitation effects during media treatment and very modest shifts in pH values observed indicated sufficient compatibility of the formulations evaluated with the HTST-processing conditions. Unsupervised chemometric analysis of LC-MS/MS data, however, revealed clear separation of HTST-treated samples from untreated counterparts as observed from analysis of principal components and hierarchical clustering sample grouping. An increased presence of Maillard products in HTST-treated formulations contributed to the observed differences which included organic acids, observed particularly in chemically defined formulations, and furans, pyridines, pyrazines, and pyrrolidines which were determined in hydrolysate-supplemented formulations. The presence of Maillard products in media did not affect cell culture performance with similar growth and viability profiles observed for CHO-K1 and CHO-DP12 cells when cultured using both HTST-treated and untreated media formulations.

  12. Strategy Formulation in Small Enterprises: A Developmental Approach. (United States)

    Paton, Robert; Brownlie, Douglas


    The Small Company European Analysis Technique is a diagnostic tool that small businesses can use to analyze market opportunities in preparation for 1992. The approach uses small group consensus building as in the Delphi technique and brainstorming to formulate a strategic plan. (SK)

  13. A minimalist functional group (MFG) approach for surrogate fuel formulation

    KAUST Repository

    Abdul Jameel, Abdul Gani


    Surrogate fuel formulation has drawn significant interest due to its relevance towards understanding combustion properties of complex fuel mixtures. In this work, we present a novel approach for surrogate fuel formulation by matching target fuel functional groups, while minimizing the number of surrogate species. Five key functional groups; paraffinic CH, paraffinic CH, paraffinic CH, naphthenic CH–CH and aromatic C–CH groups in addition to structural information provided by the Branching Index (BI) were chosen as matching targets. Surrogates were developed for six FACE (Fuels for Advanced Combustion Engines) gasoline target fuels, namely FACE A, C, F, G, I and J. The five functional groups present in the fuels were qualitatively and quantitatively identified using high resolution H Nuclear Magnetic Resonance (NMR) spectroscopy. A further constraint was imposed in limiting the number of surrogate components to a maximum of two. This simplifies the process of surrogate formulation, facilitates surrogate testing, and significantly reduces the size and time involved in developing chemical kinetic models by reducing the number of thermochemical and kinetic parameters requiring estimation. Fewer species also reduces the computational expenses involved in simulating combustion in practical devices. The proposed surrogate formulation methodology is denoted as the Minimalist Functional Group (MFG) approach. The MFG surrogates were experimentally tested against their target fuels using Ignition Delay Times (IDT) measured in an Ignition Quality Tester (IQT), as specified by the standard ASTM D6890 methodology, and in a Rapid Compression Machine (RCM). Threshold Sooting Index (TSI) and Smoke Point (SP) measurements were also performed to determine the sooting propensities of the surrogates and target fuels. The results showed that MFG surrogates were able to reproduce the aforementioned combustion properties of the target FACE gasolines across a wide range of conditions

  14. A minimalist functional group (MFG) approach for surrogate fuel formulation

    KAUST Repository

    Abdul Jameel, Abdul Gani; Naser, Nimal; Issayev, Gani; Touitou, Jamal; Ghosh, Manik Kumer; Emwas, Abdul-Hamid M.; Farooq, Aamir; Dooley, Stephen; Sarathy, Mani


    Surrogate fuel formulation has drawn significant interest due to its relevance towards understanding combustion properties of complex fuel mixtures. In this work, we present a novel approach for surrogate fuel formulation by matching target fuel functional groups, while minimizing the number of surrogate species. Five key functional groups; paraffinic CH, paraffinic CH, paraffinic CH, naphthenic CH–CH and aromatic C–CH groups in addition to structural information provided by the Branching Index (BI) were chosen as matching targets. Surrogates were developed for six FACE (Fuels for Advanced Combustion Engines) gasoline target fuels, namely FACE A, C, F, G, I and J. The five functional groups present in the fuels were qualitatively and quantitatively identified using high resolution H Nuclear Magnetic Resonance (NMR) spectroscopy. A further constraint was imposed in limiting the number of surrogate components to a maximum of two. This simplifies the process of surrogate formulation, facilitates surrogate testing, and significantly reduces the size and time involved in developing chemical kinetic models by reducing the number of thermochemical and kinetic parameters requiring estimation. Fewer species also reduces the computational expenses involved in simulating combustion in practical devices. The proposed surrogate formulation methodology is denoted as the Minimalist Functional Group (MFG) approach. The MFG surrogates were experimentally tested against their target fuels using Ignition Delay Times (IDT) measured in an Ignition Quality Tester (IQT), as specified by the standard ASTM D6890 methodology, and in a Rapid Compression Machine (RCM). Threshold Sooting Index (TSI) and Smoke Point (SP) measurements were also performed to determine the sooting propensities of the surrogates and target fuels. The results showed that MFG surrogates were able to reproduce the aforementioned combustion properties of the target FACE gasolines across a wide range of conditions

  15. A formative approach to cultural content learning in intercultural foreign language teaching

    Directory of Open Access Journals (Sweden)

    Andrijević Maja M.


    Full Text Available The paper outlines the effectiveness of the formative approach in the adoption of cultural content as part of intercultural foreign language teaching. In contrast to the informative, the formative approach is based on a constructivist approach to foreign language acquisition; in other words, it is a process of tertiary socialization through the construction of an intercultural identity, by means of experiential acquisition, interaction and cognitive conflict with previously adopted patterns. Byram's (1997 propositions about the importance of acquiring intercultural competence in foreign language teaching represent a complete shift towards a formative approach since they formulate general educational goals according to which it is impossible to have an insight into the language reality of a different culture unless an individual is aware of their own and the relative nature of both, which is vital to the development of critical intercultural awareness. Thus the focus of teaching shifts to the integration of the target and the source cultures through participatory tasks and constructive analysis, and to the construction of the learner's identity as intercultural speaker with a range of affective, cognitive and behavioral competences enabling successful contact with difference. The formative approach enables the foreign language teacher, whose role has also been redefined, to use appropriate materials in order to develop critical thinking and intercultural competence in students through their active involvement in the process of target language acquisition.

  16. Approaches to understand culture

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard; Rauner, Felix


    Different approaches to understand the concept ofculture are presented and evaluated. The author'sconcept of culture is defined. Different aspectsof the concept are discussed.......Different approaches to understand the concept ofculture are presented and evaluated. The author'sconcept of culture is defined. Different aspectsof the concept are discussed....

  17. An Integrated Approach for Non-Recursive Formulation of Connection-Coefficients of Orthogonal Functions

    Directory of Open Access Journals (Sweden)

    Monika GARG


    Full Text Available In this paper, an integrated approach is proposed for non-recursive formulation of connection coefficients of different orthogonal functions in terms of a generic orthogonal function. The application of these coefficients arises when the product of two orthogonal basis functions are to be expressed in terms of single basis functions. Two significant advantages are achieved; one, the non-recursive formulations avoid memory and stack overflows in computer implementations; two, the integrated approach provides for digital hardware once-designed can be used for different functions. Computational savings achieved with the proposed non-recursive formulation vis-à-vis recursive formulation, reported in the literature so far, have been demonstrated using MATLAB PROFILER.

  18. Methodological approach to participatory formulation of agricultural technical assistance plans with territorial approach

    Directory of Open Access Journals (Sweden)

    Holmes Rodríguez Espinosa


    Full Text Available The collective identification of needs and shared decision-making in projects’ formulation for agricultural development is a process that requires the identification of participatory methodologies to promote active and reflective engagement of producers. The aim of this study was to evaluate a methodological approach for participatory formulation of technical assistance plan with territorial approach. Matrix analysis for the identification and prioritization of the most limiting technical assistance factors for milk production was performed and alternative solutions were defined, through participatory workshops with farmers. The results show the advantages of a collective reflection with stakeholders and quantitative tools reducing subjectivity in decision-making, improving participation in their own development and identifying acceptable alternatives to farmers and viable to the municipality in order to improve lack of pasture and forage management, implementation of good agricultural practices GAP and rational use of agrochemicals.

  19. Training on the DSM-5 Cultural Formulation Interview improves cultural competence in general psychiatry residents: A pilot study. (United States)

    Mills, Stacia; Xiao, Anna Q; Wolitzky-Taylor, Kate; Lim, Russell; Lu, Francis G


    The objective of this study was to assess whether a 1-hour didactic session on the DSM-5 Cultural Formulation Interview (CFI) improves the cultural competence of general psychiatry residents. The main hypothesis was that teaching adult psychiatry residents a 1-hour session on the CFI would improve cultural competence. The exploratory hypothesis was that trainees with more experience in cultural diversity would have a greater increase in cultural competency scores. Psychiatry residents at a metropolitan, county hospital completed demographics and preintervention questionnaires, were exposed to a 1-hour session on the CFI, and were given a postintervention questionnaire. The questionnaire was an adapted version of the validated Cultural Competence Assessment Tool . Paired samples t tests compared pre- to posttest change. Hierarchical linear regression assessed whether pretraining characteristics predicted posttest scores. The mean change of total pre- and posttest scores was significant ( p = .002), as was the mean change in subscales Nonverbal Communications ( p < .001) and Cultural Knowledge ( p = .002). Demographic characteristics did not predict higher posttest scores (when covarying for pretest scores). Psychiatry residents' cultural competence scores improved irrespective of previous experience in cultural diversity. More research is needed to further explore the implications of the improved scores in clinical practice.

  20. Changing Formulations of the Man-Environment Relationship in Anglo-American Geography (United States)

    Jeans, D. N.


    The following six formulations of the Man-Environment relationship have held successive favor in Geography since the 1900's: Economic Determinism, Possibilism, Cultural Relativism, the Landscape School, Perception of Environment, and Ecological Approach. (JH)

  1. Solid effervescent formulations as new approach for topical minoxidil delivery. (United States)

    Pereira, Maíra N; Schulte, Heidi L; Duarte, Natane; Lima, Eliana M; Sá-Barreto, Livia L; Gratieri, Tais; Gelfuso, Guilherme M; Cunha-Filho, Marcilio S S


    Currently marketed minoxidil formulations present inconveniences that range from a grease hard aspect they leave on the hair to more serious adverse reactions as scalp dryness and irritation. In this paper we propose a novel approach for minoxidil sulphate (MXS) delivery based on a solid effervescent formulation. The aim was to investigate whether the particle mechanical movement triggered by effervescence would lead to higher follicle accumulation. Preformulation studies using thermal, spectroscopic and morphological analysis demonstrated the compatibility between effervescent salts and the drug. The effervescent formulation demonstrated a 2.7-fold increase on MXS accumulation into hair follicles casts compared to the MXS solution (22.0±9.7μg/cm 2 versus 8.3±4.0μg/cm 2 ) and a significant drug increase (around 4-fold) in remaining skin (97.1±29.2μg/cm 2 ) compared to the drug solution (23.5±6.1μg/cm 2 ). The effervescent formulations demonstrated a prominent increase of drug permeation highly dependent on the effervescent mixture concentration in the formulation, confirming the hypothesis of effervescent reaction favoring drug penetration. Clinically, therapy effectiveness could be improved, increasing the administration interval, hence, patient compliance. More studies to investigate the follicular targeting potential and safety of new formulations are needed. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. A new formulation of Stokes’ approach in determining the global gravimetric geoid

    Directory of Open Access Journals (Sweden)

    Wen-Bin Shen


    Full Text Available According to Stokes’ approach, given the gravity anomaly on the geoid as the boundary, a disturbing potential function satisfying some boundary conditions should be solved. The basic requirement is that the disturbing potential function should be harmonic in the region outside the geoid. However, since the normal gravity potential is not defined inside the reference ellipsoid (taking the WGS84 ellipsoid as an example, when the geoid is below the ellipsoidal surface, the disturbing potential function is not harmonic in the whole region outside the geoid, and is not defined on the whole geoid itself. These are theoretical difficulties in Stokes’ approach. To remove these difficulties from Stokes’ approach, this study provides a new formulation of Stokes’ approach. An inner ellipsoid with four fundamental parameters is chosen, two of which, the geocentric gravitational constant and the rotational angular velocity, coincide with the corresponding parameters of the WGS84 ellipsoid. The other two parameters, the semi-major axis and flattening, are different from the corresponding ones of the ellipsoid. Then, the normal gravity potential generated by the inner ellipsoid is determined, by requiring that it holds a constant on the surface of the inner ellipsoid or on the surface of the ellipsoid. With this new formulation, the disturbing potential function is harmonic in the whole region outside the geoid, and the difficulties in Stokes’ approach disappear. The new formulation proposed in this study is also adequate for analogous geodetic boundary-value problems.

  3. Serum-free media formulations are cell line-specific and require optimization for microcarrier culture. (United States)

    Tan, Kah Yong; Teo, Kim Leng; Lim, Jessica F Y; Chen, Allen K L; Choolani, Mahesh; Reuveny, Shaul; Chan, Jerry; Oh, Steve Kw


    Mesenchymal stromal cells (MSCs) are being investigated as potential cell therapies for many different indications. Current methods of production rely on traditional monolayer culture on tissue-culture plastic, usually with the use of serum-supplemented growth media. However, the monolayer culturing system has scale-up limitations and may not meet the projected hundreds of billions to trillions batches of cells needed for therapy. Furthermore, serum-free medium offers several advantages over serum-supplemented medium, which may have supply and contaminant issues, leading to many serum-free medium formulations being developed. We cultured seven MSC lines in six different serum-free media and compared their growth between monolayer and microcarrier culture. We show that (i) expansion levels of MSCs in serum-free monolayer cultures may not correlate with expansion in serum-containing media; (ii) optimal culture conditions (serum-free media for monolayer or microcarrier culture) differ for each cell line; (iii) growth in static microcarrier culture does not correlate with growth in stirred spinner culture; (iv) and that early cell attachment and spreading onto microcarriers does not necessarily predict efficiency of cell expansion in agitated microcarrier culture. Current serum-free media developed for monolayer cultures of MSCs may not support MSC proliferation in microcarrier cultures. Further optimization in medium composition will be required for microcarrier suspension culture for each cell line. Copyright © 2015 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

  4. Loss, Psychosis, and Chronic Suicidality in a Korean American Immigrant Man: Integration of Cultural Formulation Model and Multicultural Case Conceptualization


    Shea, Munyi; Yang, Lawrence H.; Leong, Frederick T. L.


    Culture shapes the nature, experience, and expression of psychopathology and help-seeking behavior across ethnically diverse groups. Although the study of psychopathology among Asian Americans has advanced, clinicians remain in need of culturally appropriate tools for the assessment and diagnosis of severe mental disorders including psychotic symptoms among Asian Americans. In this article, we present a brief overview of two culturally relevant conceptual tools: a) the Cultural Formulation Mo...

  5. Precipitation in Powder Metallurgy, Nickel Base Superalloys: Review of Modeling Approach and Formulation of Engineering (Postprint) (United States)



  6. Personality and culture, the Social Science Research Council, and liberal social engineering: the Advisory Committee on Personality and Culture, 1930-1934. (United States)

    Bryson, Dennis


    The field of personality and culture was given a significant impetus during the 1930s with the establishment of the Advisory Committee on Personality and Culture (1930-1934) by the Social Science Research Council. This committee provided an early formulation of personality and culture that emphasized the interdisciplinary focus on the processes of personality formation within small-scale social settings. The committee's formulation also coupled personality and culture with a liberal social engineering approach geared toward cultural reconstruction. Major social scientists and clinicians were involved in the activities of the committee, including Edward Sapir, W. I. Thomas, E. W. Burgess, E. A. Bott, Robert S. Woodworth, Harry Stack Sullivan, C. M. Hincks, and Adolf Meyer.

  7. Standardization of Unani polyherbal formulation, Qurse-e-Hummaz: A comprehensive approach

    Directory of Open Access Journals (Sweden)

    Y T Kamal


    Full Text Available Background: An increase in the awareness about the advantages of the traditional system of medicines has led to the commercialization of the formulations used for the treatments. Manufacture of these medicines to meet this increasing demand has resulted in a decline in their quality, primarily due to a lack of adequate regulations pertaining to this sector of medicine. Hence, it is necessary to come up with a systematic approach to develop well-designed methodologies for the standardization of polyherbal formulations which are used in traditional systems of medicine. Materials and Methods: Qurs-e-Hummaz formulations were prepared by a qualified “Hakim” (Unani medical practitioner of Faculty of Unani Medicine, Hamdard University, as per the formula and instruction given in National Formulary of Unani Medicine. Results: Various quality control parameters such as organoleptic evaluations (color, odor, taste, and consistency, physicochemical evaluations (loss on drying, disintegration time, moisture content, total ash, acid insoluble ash, water soluble ash, pH of 1 and 10% solution, extractive values, water soluble matter, alcohol-soluble matter, and total phenolic content and thin layer chromatography fingerprint profiling have been carried out in triplicate. The evaluation of contaminants such as heavy metals, aflatoxins, pesticide residues, and microbial contamination has also been carried out in the formulation. Conclusion: Help in maintaining the quality and batch to batch consistency of many important polyherbal formulations.

  8. Methodological approaches in the research of organizational culture

    Directory of Open Access Journals (Sweden)

    Janićijević Nebojša


    Full Text Available In the thirty-years-long research of organizational culture, two mutually opposed methodological approaches have emerged: objectivistic quantitative and subjectivistic-qualitative. These two approaches are based on opposite ontological and epistemological assumptions: they include different types of research, and use opposite, quantitative vs. qualitative, methods of research. Each of the methodological approaches has its advantages and disadvantages. For this reason a hybrid approach emerges as a legitimate choice in organizational culture research methodology. It combines elements of both subjectivistic and objectivistic methodological approaches, according to the goals, content, and context of the research and preferences of the researcher himself/herself. Since it is possible to combine the two principal methodological approaches in various ways, there are several possible hybrid methodologies in organizational culture research. After the review of objectivistic quantitative and subjectivistic-qualitative methodological approaches, one of possible hybrid approaches in the research of organizational culture is presented in this paper.

  9. Formulation and Optimization of Multiparticulate Drug Delivery System Approach for High Drug Loading. (United States)

    Shah, Neha; Mehta, Tejal; Gohel, Mukesh


    The aim of the present work was to develop and optimize multiparticulate formulation viz. pellets of naproxen by employing QbD and risk assessment approach. Mixture design with extreme vertices was applied to the formulation with high loading of drug (about 90%) and extrusion-spheronization as a process for manufacturing pellets. Independent variables chosen were level of microcrystalline cellulose (MCC)-X 1 , polyvinylpyrrolidone K-90 (PVP K-90)-X 2 , croscarmellose sodium (CCS)-X 3 , and polacrilin potassium (PP)-X 4 . Dependent variables considered were disintegration time (DT)-Y 1 , sphericity-Y 2 , and percent drug release-Y 3 . The formulation was optimized based on the batches generated by MiniTab 17 software. The batch with maximum composite desirability (0.98) proved to be optimum. From the evaluation of design batches, it was observed that, even in low variation, the excipients affect the pelletization property of the blend and also the final drug release. In conclusion, pellets with high drug loading can be effectively manufactured and optimized systematically using QbD approach.

  10. Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films

    NARCIS (Netherlands)

    Visser, J. Caroline; Dohmen, Willem M. C.; Hinrichs, Wouter L. J.; Breitkreutz, Joerg; Frijlink, Henderik W.; Woerdenbag, Herman J.


    The quality by design (QbD) approach was applied for optimizing the formulation of extemporaneously prepared orodispersible films (ODFs) using Design-Expert Software. The starting formulation was based on earlier experiments and contained the film forming agents hypromellose and carbomer 974P and

  11. Modern approach to relativity theory (radar formulation)

    International Nuclear Information System (INIS)

    Strel'tsov, V.N.


    The main peculiarities of the radar formulation of the relativity theory are presented. This formulation operates with the retarded (light) distances and relativistic or radar length introduced on their basis. 21 refs.; 1 tab

  12. Complexation of c6-ceramide with cholesteryl phosphocholine - a potent solvent-free ceramide delivery formulation for cells in culture.

    Directory of Open Access Journals (Sweden)

    Pramod Sukumaran

    Full Text Available Ceramides are potent bioactive molecules in cells. However, they are very hydrophobic molecules, and difficult to deliver efficiently to cells. We have made fluid bilayers from a short-chain D-erythro-ceramide (C6-Cer and cholesteryl phosphocholine (CholPC, and have used this as a formulation to deliver ceramide to cells. C6-Cer complexed with CholPC led to much larger biological effects in cultured cells (rat thyroid FRTL-5 and human HeLa cells in culture compared to C6-Cer dissolved in dimethyl sulfoxide (DMSO. Inhibition of cell proliferation and induction of apoptosis was significantly more efficient by C6-Cer/CholPC compared to C6-Cer dissolved in DMSO. C6-Cer/CholPC also permeated cell membranes and caused mitochondrial Ca(2+ influx more efficiently than C6-Cer in DMSO. Even though CholPC was taken up by cells to some extent (from C6-Cer/CholPC bilayers, and was partially hydrolyzed to free cholesterol (about 9%, none of the antiproliferative effects were due to CholPC or excess cholesterol. The ceramide effect was not limited to D-erythro-C6-Cer, since L-erythro-C6-Cer and D-erythro-C6-dihydroCer also inhibited cell priolifereation and affected Ca(2+ homeostasis. We conclude that C6-Cer complexed to CholPC increased the bioavailability of the short-chain ceramide for cells, and potentiated its effects in comparison to solvent-dissolved C6-Cer. This new ceramide formulation appears to be superior to previous solvent delivery approaches, and may even be useful with longer-chain ceramides.

  13. Influence of the DSM-IV Outline for Cultural Formulation on multidisciplinary case conferences in mental health. (United States)

    Dinh, Nathalie M H; Groleau, Danielle; Kirmayer, Laurence J; Rodriguez, Charo; Bibeau, Gilles


    The Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association (DSM-IV-TR) includes an Outline for Cultural Formulation (CF) that identifies cultural information that can be used to modify diagnosis, clinical assessment and treatment plan. This study examined the use of the CF by a Cultural Consultation Service in the psychiatric assessment of patients referred by primary care providers. The study uses conversation analysis of 12 clinical case conferences to explore the ways in which the CF influenced the interaction of a multidisciplinary group of mental health professionals in conceptualizing the implications of patients' cultural background and current context for diagnosis and treatment planning. The results suggest that the CF can be a useful tool for interdisciplinary collaboration and knowledge transfer by providing a framework to systematically introduce different disciplinary perspectives and levels of description that transcend the narrow frame of disorder-centred psychiatric diagnosis, assessment and care.

  14. Rapid assessment of viable but non-culturable Bacillus coagulans MTCC 5856 in commercial formulations using Flow cytometry (United States)

    Majeed, Muhammed; Majeed, Shaheen; Nagabhushanam, Kalyanam; Punnapuzha, Ardra; Philip, Sheena


    Accurate enumeration of bacterial count in probiotic formulation is imperative to ensure that the product adheres to regulatory standards and citation in consumer product label. Standard methods like plate count, can enumerate only replicating bacterial population under selected culture conditions. Viable but non culturable bacteria (VBNC) retain characteristics of living cells and can regain cultivability by a process known as resuscitation. This is a protective mechanism adapted by bacteria to evade stressful environmental conditions. B. coagulans MTCC 5856(LactoSpore®) is a probiotic endospore which can survive for decades in hostile environments without dividing. In the present study, we explored the use of flow cytometry to enumerate the viable count of B. coagulans MTCC 5856 under acidic and alkaline conditions, high temperature and in commercial formulations like compressed tablets and capsules. Flow cytometry (FCM) was comparable to plate count method when the spores were counted at physiological conditions. We show that VBNC state is induced in B. coagulans MTCC 5856by high temperature and acidic pH. The cells get resuscitated under physiological conditions and FCM was sensitive to detect the VBNC spores. Flow cytometry showed excellent ability to assess the viable spore count in commercial probiotic formulations of B. coagulans MTCC 5856. The results establish Flow cytometry as a reliable method to count viable bacteria in commercial probiotic preparations. Sporulation as well as existence as VBNC could contribute to the extreme stability of B. coagulans MTCC 5856. PMID:29474436

  15. Rapid assessment of viable but non-culturable Bacillus coagulans MTCC 5856 in commercial formulations using Flow cytometry.

    Directory of Open Access Journals (Sweden)

    Muhammed Majeed

    Full Text Available Accurate enumeration of bacterial count in probiotic formulation is imperative to ensure that the product adheres to regulatory standards and citation in consumer product label. Standard methods like plate count, can enumerate only replicating bacterial population under selected culture conditions. Viable but non culturable bacteria (VBNC retain characteristics of living cells and can regain cultivability by a process known as resuscitation. This is a protective mechanism adapted by bacteria to evade stressful environmental conditions. B. coagulans MTCC 5856(LactoSpore® is a probiotic endospore which can survive for decades in hostile environments without dividing. In the present study, we explored the use of flow cytometry to enumerate the viable count of B. coagulans MTCC 5856 under acidic and alkaline conditions, high temperature and in commercial formulations like compressed tablets and capsules. Flow cytometry (FCM was comparable to plate count method when the spores were counted at physiological conditions. We show that VBNC state is induced in B. coagulans MTCC 5856by high temperature and acidic pH. The cells get resuscitated under physiological conditions and FCM was sensitive to detect the VBNC spores. Flow cytometry showed excellent ability to assess the viable spore count in commercial probiotic formulations of B. coagulans MTCC 5856. The results establish Flow cytometry as a reliable method to count viable bacteria in commercial probiotic preparations. Sporulation as well as existence as VBNC could contribute to the extreme stability of B. coagulans MTCC 5856.

  16. Rapid assessment of viable but non-culturable Bacillus coagulans MTCC 5856 in commercial formulations using Flow cytometry. (United States)

    Majeed, Muhammed; Majeed, Shaheen; Nagabhushanam, Kalyanam; Punnapuzha, Ardra; Philip, Sheena; Mundkur, Lakshmi


    Accurate enumeration of bacterial count in probiotic formulation is imperative to ensure that the product adheres to regulatory standards and citation in consumer product label. Standard methods like plate count, can enumerate only replicating bacterial population under selected culture conditions. Viable but non culturable bacteria (VBNC) retain characteristics of living cells and can regain cultivability by a process known as resuscitation. This is a protective mechanism adapted by bacteria to evade stressful environmental conditions. B. coagulans MTCC 5856(LactoSpore®) is a probiotic endospore which can survive for decades in hostile environments without dividing. In the present study, we explored the use of flow cytometry to enumerate the viable count of B. coagulans MTCC 5856 under acidic and alkaline conditions, high temperature and in commercial formulations like compressed tablets and capsules. Flow cytometry (FCM) was comparable to plate count method when the spores were counted at physiological conditions. We show that VBNC state is induced in B. coagulans MTCC 5856by high temperature and acidic pH. The cells get resuscitated under physiological conditions and FCM was sensitive to detect the VBNC spores. Flow cytometry showed excellent ability to assess the viable spore count in commercial probiotic formulations of B. coagulans MTCC 5856. The results establish Flow cytometry as a reliable method to count viable bacteria in commercial probiotic preparations. Sporulation as well as existence as VBNC could contribute to the extreme stability of B. coagulans MTCC 5856.

  17. Toward a new approach to the study of personality in culture. (United States)

    Cheung, Fanny M; van de Vijver, Fons J R; Leong, Frederick T L


    We review recent developments in the study of culture and personality measurement. Three approaches are described: an etic approach that focuses on establishing measurement equivalence in imported measures of personality, an emic (indigenous) approach that studies personality in specific cultures, and a combined emic-etic approach to personality. We propose the latter approach as a way of combining the methodological rigor of the etic approach and the cultural sensitivity of the emic approach. The combined approach is illustrated by two examples: the first with origins in Chinese culture and the second in South Africa. The article ends with a discussion of the theoretical and practical implications of the combined emic-etic approach for the study of culture and personality and for psychology as a science.

  18. Information cultures

    DEFF Research Database (Denmark)

    Skouvig, Laura


    The purpose of this article is to suggest a genealogy of the concept of information beyond the 20th century. The article discusses how the concept of information culture might provide a way of formulating such a genealogic strategy. The article approaches this purpose by providing a general...... narrative of premodern information cultures, examining works on early-modern scholars and 18th century savants and discussion of what seems to be a Foucauldian rupture in the conceptualization of information in 19th century England. The findings of the article are situated in the thinking that a genealogy...... of information would reveal that information had specific purposes in specific settings....

  19. A cultural psychological approach to evangelical faith healing groups

    NARCIS (Netherlands)

    van Saane, J.W.


    From the perspective of Belzen, a cultural approach for the psychology of religion is necessary to cope with the multiplicity of the religious phenomenon. He presents research of specific - very closed - religious groups to illustrate this point. A cultural approach is not limited to these specific

  20. Promoting Teachers of Culturally and Linguistically Diverse (CLD) Students as Change Agents: A Cultural Approach to Professional Learning (United States)

    Li, Guofang


    This article proposes a cultural approach to professional learning to empower pre- and in-service teachers to successfully address increasingly diverse student populations and become culturally responsive to students' diverse backgrounds. This cultural approach treats culture as a vital source for reshaping the politics of identity and…

  1. Approaches to culture and diversity: A critical synthesis of occupational therapy literature. (United States)

    Beagan, Brenda L


    The 2007 position statement on diversity for the Canadian occupational therapy profession argued discussion was needed to determine the implications of approaches to working with cultural differences and other forms of diversity. In 2014, a new position statement on diversity was published, emphasizing the importance of social power relations and power relations between client and therapist, and supporting two particular approaches: cultural safety and cultural humility with critical reflexivity This paper reviews and critically synthesizes the literature concerning culture and diversity published in occupational therapy between 2007 and 2014, tracing the major discourses and mapping the implications of four differing approaches: cultural competence, cultural relevance, cultural safety, and cultural humility. Approaches differ in where they situate the "problem," how they envision change, the end goal, and the application to a range of types of diversity. The latter two are preferred approaches for their attention to power relations and potential to encompass a range of types of social and cultural diversity. © CAOT 2015.


    Directory of Open Access Journals (Sweden)



    Full Text Available Formulation of the problem. One of the main features of modern tourism is the concept of its development based on sustainable development. Ecotourism, provided cultural approach to its organization, is an important means to improve the level of ecological culture of society and quality of life, maintain a balance in nature and the balanced development of the regions of our country. The necessary condition for the attractiveness of green tourism is an information and education activities media about public 'associations, educational and socio-cultural organizations, cultural approach to the planning and management of tourism activities.

  3. Economic Systems: A Modular Approach. Cultural Anthropology. (United States)

    Kassebaum, Peter

    Designed for use as supplementary instructional material in a cultural anthropology course, this learning module uses a systems approach to allow students to see the connections and similarities which most cultural groups share on the basis of the type of economic organization that they exhibit. The module begins with a general discussion of…

  4. Development of a versatile high-temperature short-time (HTST) pasteurization device for small-scale processing of cell culture medium formulations. (United States)

    Floris, Patrick; Curtin, Sean; Kaisermayer, Christian; Lindeberg, Anna; Bones, Jonathan


    The compatibility of CHO cell culture medium formulations with all stages of the bioprocess must be evaluated through small-scale studies prior to scale-up for commercial manufacturing operations. Here, we describe the development of a bespoke small-scale device for assessing the compatibility of culture media with a widely implemented upstream viral clearance strategy, high-temperature short-time (HTST) treatment. The thermal stability of undefined medium formulations supplemented with soy hydrolysates was evaluated upon variations in critical HTST processing parameters, namely, holding times and temperatures. Prolonged holding times of 43 s at temperatures of 110 °C did not adversely impact medium quality while significant degradation was observed upon treatment at elevated temperatures (200 °C) for shorter time periods (11 s). The performance of the device was benchmarked against a commercially available mini-pilot HTST system upon treatment of identical formulations on both platforms. Processed medium samples were analyzed by untargeted LC-MS/MS for compositional profiling followed by chemometric evaluation, which confirmed the observed degradation effects caused by elevated holding temperatures but revealed comparable performance of our developed device with the commercial mini-pilot setup. The developed device can assist medium optimization activities by reducing volume requirements relative to commercially available mini-pilot instrumentation and by facilitating fast throughput evaluation of heat-induced effects on multiple medium lots.

  5. Formulation of the endophytic fungus Cladosporium oxysporum Berk.

    Directory of Open Access Journals (Sweden)

    Bensaci Oussama Ali


    Full Text Available Two formulations containing culture filtrates and conidial suspensions of the endophytic fungus Cladosporium oxysporum Berk. & M.A. Curtis, isolated previously from stems of Euphorbia bupleuroides subsp. luteola (Kralik Maire, were experimentally tested for their aphicid activity against the black bean aphid Aphis fabae Scop. found in Algeria. It was shown that invert emulsions are more effective against aphids, than using aqueous suspensions. This was especially true for formulations containing culture filtrates. The relatively insignificant mortalities obtained by formulations containing conidial suspensions indicated a low infectious potential towards the aphids. The proteolytic activity seemed to be more important than the chitinolytic activity of the fungus against the black bean aphid A. fabae

  6. Toward a New Approach to the Study of Personality in Culture (United States)

    Cheung, Fanny M.; van de Vijver, Fons J. R.; Leong, Frederick T. L.


    We review recent developments in the study of culture and personality measurement. Three approaches are described: an etic approach that focuses on establishing measurement equivalence in imported measures of personality, an emic (indigenous) approach that studies personality in specific cultures, and a combined emic-etic approach to personality.…

  7. Effect of cell culture medium components on color of formulated monoclonal antibody drug substance. (United States)

    Vijayasankaran, Natarajan; Varma, Sharat; Yang, Yi; Mun, Melissa; Arevalo, Silvana; Gawlitzek, Martin; Swartz, Trevor; Lim, Amy; Li, Feng; Zhang, Boyan; Meier, Steve; Kiss, Robert


    As the industry moves toward subcutaneous delivery as a preferred route of drug administration, high drug substance concentrations are becoming the norm for monoclonal antibodies. At such high concentrations, the drug substance may display a more intense color than at the historically lower concentrations. The effect of process conditions and/or changes on color is more readily observed in the higher color, high concentration formulations. Since color is a product quality attribute that needs to be controlled, it is useful to study the impact of process conditions and/or modifications on color. This manuscript summarizes cell culture experiments and reports on findings regarding the effect of various media components that contribute to drug substance color for a specific monoclonal antibody. In this work, lower drug substance color was achieved via optimization of the cell culture medium. Specifically, lowering the concentrations of B-vitamins in the cell culture medium has the effect of reducing color intensity by as much as 25%. In addition, decreasing concentration of iron was also directly correlated color intensity decrease of as much as 37%. It was also shown that the color of the drug substance directly correlates with increased acidic variants, especially when increased iron levels cause increased color. Potential mechanisms that could lead to antibody coloration are briefly discussed. © 2013 American Institute of Chemical Engineers.

  8. Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route. (United States)

    Jain, Shashank; Patel, Niketkumar; Madan, Parshotam; Lin, Senshang


    The objective of this study was to fabricate and understand ethosomal formulations of diclofenac (DF) for enhanced anti-inflammatory activity using quality by design approach. DF-loaded ethosomal formulations were prepared using 4 × 5 full-factorial design with phosphatidylcholine:cholesterol (PC:CH) ratios ranging between 50:50 and 90:10, and ethanol concentration ranging between 0% and 30% as formulation variables. These formulations were characterized in terms of physicochemical properties and skin permeation kinetics. The interaction of formulation variables had a significant effect on both physicochemical properties and permeation kinetics. The results of multivariate regression analysis illustrated that vesicle size and elasticity of ethosomes were the dominating physicochemical properties affecting skin permeation, and could be suitably controlled by manipulation of formulation variables to optimize the formulation and enhance the skin permeation of DF-loaded ethosomes. The optimized formulation had ethanol concentration of 22.9% and PC:CH ratio of 88.4:11.6, with vesicle size of 144 ± 5 nm, zeta potential of -23.0 ± 3.76 mV, elasticity of 2.48 ± 0.75 and entrapment efficiency of 71 ± 4%. Permeation flux for the optimized formulation was 12.9 ± 1.0 µg/h cm(2), which was significantly higher than the drug-loaded conventional liposome, ethanolic or aqueous solution. The in vivo study indicated that optimized ethosomal hydrogel exhibited enhanced anti-inflammatory activity compared with liposomal and plain drug hydrogel formulations.

  9. Native American Culture: An Interdisciplinary Approach. (United States)

    Troisi, Andrea


    Provides suggestions for a literature-based approach when integrating Native American culture into the middle school curriculum. Recommends resources in the following subjects: language arts, mathematics, physical education, health, home and career skills, technology, art, music, and second language. (AEF)

  10. Approach--avoidance motivation and information processing: a cross-cultural analysis. (United States)

    Hamamura, Takeshi; Meijer, Zita; Heine, Steven J; Kamaya, Kengo; Hori, Izumi


    Much recent research suggests that North Americans more frequently experience approach motivations and East Asians more frequently experience avoidance motivations. The current research explores some cognitive implications of this cultural difference. North Americans should be more attentive to approach-oriented information, whereas East Asians should be more attentive to avoidance-oriented information. Three studies confirmed this hypothesis. When asked to recall information framed in either approach or avoidance terms, a predicted interaction between culture and information frame was observed (Study 1 and 2). Moreover, analyses of consumer book reviews found that among reviews that were rated as helpful, approach-focused content was more prevalent in American reviews compared to Japanese reviews, in which avoidance-focused content was more prevalent (Study 3). Findings from the current research add to the growing literature of cross-cultural research on approach-avoidance motivations.


    Directory of Open Access Journals (Sweden)

    Maryna Lavryshsheva


    Characteristics of cultural policy, as a process, i.e. procedural approach, allows us to see the specific aspects of interaction of subjects over the governmental authorities. However, due to the fact, that in its scale cultural process is the same as political environment of the state, some scientists identify it either with politics in general or with the totality of the shares of behavioral government entities, change their status and influence. Supporters of the institutional approach associates the cultural political process with the functioning and the transformation of the government institutionы, based on a set of the political system reactions on the environmental challenges. As we speak in the current economic conditions in Ukraine is actual the development of anti-crisis measures for the rehabilitation and development of the conceptual approach of cultural policies in the region. As such, the obvious is the development of a measures set by all courses of the plan, that will mutualize the key goals, objectives and tools into a uniform system of measures. This plan should provide the combined model in the region and provide a transition to the zonal management principle of the transition period. In the plan it is also should be provided institutional support for the proposed measures, namely the mechanisms of technological and socio-cultural issues implementation in range of the cultural policy of the society [1, p.18].

  12. A Decentralized Approach to the Formulation of Hypotheses: A Hierarchical Structural Model for a Prion Self-Assembled System (United States)

    Wang, Mingyang; Zhang, Feifei; Song, Chao; Shi, Pengfei; Zhu, Jin


    Innovation in hypotheses is a key transformative driver for scientific development. The conventional centralized hypothesis formulation approach, where a dominant hypothesis is typically derived from a primary phenomenon, can, inevitably, impose restriction on the range of conceivable experiments and legitimate hypotheses, and ultimately impede understanding of the system of interest. We report herein the proposal of a decentralized approach for the formulation of hypotheses, through initial preconception-free phenomenon accumulation and subsequent reticular logical reasoning processes. The two-step approach can provide an unbiased, panoramic view of the system and as such should enable the generation of a set of more coherent and therefore plausible hypotheses. As a proof-of-concept demonstration of the utility of this open-ended approach, a hierarchical model has been developed for a prion self-assembled system, allowing insight into hitherto elusive static and dynamic features associated with this intriguing structure.

  13. Evolutionary approaches to cultural and linguistic diversity. (United States)

    Steele, James; Jordan, Peter; Cochrane, Ethan


    Evolutionary approaches to cultural change are increasingly influential, and many scientists believe that a 'grand synthesis' is now in sight. The papers in this Theme Issue, which derives from a symposium held by the AHRC Centre for the Evolution of Cultural Diversity (University College London) in December 2008, focus on how the phylogenetic tree-building and network-based techniques used to estimate descent relationships in biology can be adapted to reconstruct cultural histories, where some degree of inter-societal diffusion will almost inevitably be superimposed on any deeper signal of a historical branching process. The disciplines represented include the three most purely 'cultural' fields from the four-field model of anthropology (cultural anthropology, archaeology and linguistic anthropology). In this short introduction, some context is provided from the history of anthropology, and key issues raised by the papers are highlighted.

  14. Visual Culture as a Strategic Approach to Art Production in Education

    DEFF Research Database (Denmark)

    Buhl, Mie


    The concept of visual culture challenges tradtitional approaches to art production in education. Art education lacks adequate concepts for understanding contemporary productive processes. The article suggests that the theoretical framework for the productive process should be reconsidered. Visual...... culture as a strategic approach focuses on conditions surrounding viewing rather than on the substance of aesthetic objects A new termonology is needed for use in student and teacher dialogue. The article presents a model for teaching art production bases on a visual culture approach to visual arts...

  15. Methodological Approaches in the Research of Organizational Culture


    Nebojša Janićijević


    In the thirty-years-long research of organizational culture, two mutually opposed methodological approaches have emerged: objectivistic quantitative and subjectivistic-qualitative. These two approaches are based on opposite ontological and epistemological assumptions: they include different types of research, and use opposite, quantitative vs. qualitative, methods of research. Each of the methodological approaches has its advantages and disadvantages. For this reason a hybrid approach e...

  16. The interactive role of organizational strategy and culture : a strategic management approach



    M.Com. This study has been undertaken with the specific objective of acquiring an insight into the concept "organizational culture" within a strategic management context, as well as the role played by the concept in the formulation and implementation of organizational strategy. Researchers from within various disciplines, such as anthropology, industrial psychology and strategic management, have analysed various aspects of the concept ...

  17. Space Culture: Innovative Cultural Approaches To Public Engagement With Astronomy, Space Science And Astronautics (United States)

    Malina, Roger F.


    In recent years a number of cultural organizations have established ongoing programs of public engagement with astronomy, space science and astronautics. Many involve elements of citizen science initiatives, artists’ residencies in scientific laboratories and agencies, art and science festivals, and social network projects as well as more traditional exhibition venues. Recognizing these programs several agencies and organizations have established mechanisms for facilitating public engagement with astronomy and space science through cultural activities. The International Astronautics Federation has established an Technical Activities Committee for the Cultural Utilization of Space. Over the past year the NSF and NEA have organized disciplinary workshops to develop recommendations relating to art-science interaction and community building efforts. Rationales for encouraging public engagement via cultural projects range from theory of creativity, innovation and invention to cultural appropriation in the context of `socially robust science’ as advocated by Helga Nowotny of the European Research Council. Public engagement with science, as opposed to science education and outreach initiatives, require different approaches. Just as organizations have employed education professionals to lead education activities, so they must employ cultural professionals if they wish to develop public engagement projects via arts and culture. One outcome of the NSF and NEA workshops has been development of a rationale for converting STEM to STEAM by including the arts in STEM methodologies, particularly for K-12 where students can access science via arts and cultural contexts. Often these require new kinds of informal education approaches that exploit locative media, gaming platforms, artists projects and citizen science. Incorporating astronomy and space science content in art and cultural projects requires new skills in `cultural translation’ and `trans-mediation’ and new kinds


    Directory of Open Access Journals (Sweden)



    Full Text Available In order to make evident the instrumental nature of the concept of culture applied to organization, thisessay develops a comprehension of the concept of organizational culture. This effort is important becausethe concept of organization itself implies a construction of a social order from meanings becominghegemonic in the framework of a particular context. Organizational Psychology, even with its neutralitypretension, is not innocent about the instrumental role that social sciences have had in the organizationalarena; however this essay introduces alternatives from critical approaches that allow ways of comprehensionand why not, intervention from perspectives explicitly political.

  19. Soft, chewable gelatin-based pharmaceutical oral formulations: a technical approach. (United States)

    Dille, Morten J; Hattrem, Magnus N; Draget, Kurt I


    Hard tablets and capsules for oral drug delivery cause problems for people experiencing dysphagia. This work describes the formulation and properties of a gelatin based, self-preserved, and soft chewable tablet as an alternative and novel drug delivery format. Gelatin (8.8-10% in 24.7-29% water) constituted the matrix of the soft, semi-solid tablets. Three different pharmaceuticals (Ibuprofen 10%, Acetaminophen 15%, and Meloxicam 1.5%) were tested in this formulation. Microbial stability was controlled by lowering the water activity with a mixture of sorbitol and xylitol (45.6-55%). Rheological properties were tested applying small strain oscillation measurements. Taste masking of ibuprofen soft-chew tablets was achieved by keeping the ibuprofen insoluble at pH 4.5 and keeping the processing temperature below the crystalline-to-amorphous transition temperature. Soft-chew formulations showed good stability for all three pharmaceuticals (up to 24 months), and the ibuprofen containing formulation exhibited comparable dissolution to a standard oral tablet as well as good microbial stability. The rheological properties of the ibuprofen/gelatin formulation had the fingerprint of a true gelatin gel, albeit higher moduli, and melting temperature. The results suggest that easy-to-swallow and well taste-masked soft chewable tablet formulations with extended shelf life are within reach for several active pharmaceutical ingredients (APIs).

  20. Transculturality as a Perspective: Researching Media Cultures Comparatively

    Directory of Open Access Journals (Sweden)

    Andreas Hepp


    Full Text Available Most of the research on media cultures operates in a "national-territorial" frame. Media cultures are considered as national cultures and other forms of media culture (for example professional journalism cultures, diasporas, celebrity cultures etc. are not investigated in their "deterritorial" character. But it is exactly such deterritorial forms of media culture that are gaining relevance with the ongoing pace of media globalization: they therefore have to be placed in the focus of comparative media and communication research. Starting with this consideration, the article develops a transcultural perspective on researching media cultures. Within this perspective it becomes possible to conduct comparative research on (territorial national media cultures as well as on other (deterritorial forms of present media cultures, as this approach moves the processes of cultural construction and articulation into the focus of analysis. To arrive at a better understanding of this approach, "media cultures" are defined as translocal phenomena in their territorial as well as their deterritorial relations. Based on this, the "semantics" of a transcultural research perspective are outlined, which then makes it possible to formulate practical principles for carrying out comparative qualitative research within this framework. URN: urn:nbn:de:0114-fqs0901267

  1. Becoming a Doctor in Different Cultures: Toward a Cross-Cultural Approach to Supporting Professional Identity Formation in Medicine. (United States)

    Helmich, Esther; Yeh, Huei-Ming; Kalet, Adina; Al-Eraky, Mohamed


    Becoming a doctor is fundamentally about developing a new, professional identity as a physician, which in and of itself may evoke many emotions. Additionally, medical trainees are increasingly moving from one cultural context to another and are challenged with navigating the resulting shifts in their professional identify. In this Article, the authors aim to address medical professional identity formation from a polyvocal, multidisciplinary, cross-cultural perspective. They delineate the cultural approaches to medical professionalism, reflect on professional identity formation in different cultures and on different theories of identity development, and advocate for a context-specific approach to professional identity formation. In doing so, the authors aim to broaden the developing professional identity formation discourse to include non-Western approaches and notions.

  2. Induction of osteogenic differentiation of stem cells via a lyophilized microRNA reverse transfection formulation on a tissue culture plate

    DEFF Research Database (Denmark)

    Wu, Kaimin; Xu, Jie; Liu, Mingzhe


    MicroRNA (miRNA) regulation is a novel approach to manipulating the fate of mesenchymal stem cells, but an easy, safe, and highly efficient method of transfection is required. In this study, we developed an miRNA reverse transfection formulation by lyophilizing Lipofectamine 2000-miRNA lipoplexes...... of the intracellular target miRNA level. Reverse transfection formulations containing Lipofectamine 2000 1 µL per well generated much higher transfection efficiency without obvious cytotoxicity compared with conventional and other transfection methods. Further, the transfection efficiency of the reverse transfection...... formulations did not deteriorate during 90 days of storage at 4°C and -20°C. We then assessed the efficiency of the miRNA reverse transfection formulation in promoting osteogenic differentiation of mesenchymal stem cells. We found that transfection with anti-miR-138 and miR-148b was efficient for enhancing...

  3. Combined culture-based and culture-independent approaches provide insights into diversity of jakobids, an extremely plesiomorphic eukaryotic lineage

    Directory of Open Access Journals (Sweden)

    Tomáš ePánek


    Full Text Available We used culture-based and culture-independent approaches to discover diversity and ecology of anaerobic jakobids (Excavata: Jakobida, an overlooked, deep-branching lineage of free-living nanoflagellates related to Euglenozoa. Jakobids are among a few lineages of nanoflagellates frequently detected in anoxic habitats by PCR-based studies, however only two strains of a single jakobid species have been isolated from those habitats. We recovered 712 environmental sequences and cultured 21 new isolates of anaerobic jakobids that collectively represent at least ten different species in total, from which four are uncultured. Two cultured species have never been detected by environmental, PCR-based methods. Surprisingly, culture-based and culture-independent approaches were able to reveal a relatively high proportion of overall species diversity of anaerobic jakobids - 60 % or 80 %, respectively. Our phylogenetic analyses based on SSU rDNA and six protein-coding genes showed that anaerobic jakobids constitute a clade of morphologically similar, but genetically and ecologically diverse protists – Stygiellidae fam. nov. Our investigation combines culture-based and environmental molecular-based approaches to capture a wider extent of species diversity and shows Stygiellidae as a group that ordinarily inhabits anoxic, sulfide- and ammonium-rich marine habitats worldwide.

  4. Enrichment, development, and assessment of Indian basil oil based antiseptic cream formulation utilizing hydrophilic-lipophilic balance approach. (United States)

    Yadav, Narayan Prasad; Meher, Jaya Gopal; Pandey, Neelam; Luqman, Suaib; Yadav, Kuldeep Singh; Chanda, Debabrata


    The present work was aimed to develop an antiseptic cream formulation of Indian basil oil utilizing hydrophilic-lipophilic balance approach. In order to determine the required-hydrophilic lipophilic balance (rHLB) of basil oil, emulsions of basil oil were prepared by phase inversion temperature technique using water, Tween 80, and Span 80. Formulated emulsions were assessed for creaming (BE9; 9.8, BE10; 10.2), droplet size (BE18; 3.22 ± 0.09 μ m), and turbidity (BE18; 86.12 ± 2.1%). To ensure correctness of the applied methodology, rHLB of light liquid paraffin was also determined. After rHLB determination, basil oil creams were prepared with two different combinations of surfactants, namely, GMS : Tween 80 (1 : 3.45) and SLS : GMS (1 : 3.68), and evaluated for in vitro antimicrobial activity, skin irritation test, viscosity and consistency. The rHLB of basil oil and light liquid paraffin were found to be 13.36 ± 0.36 and 11.5 ± 0.35, respectively. Viscosity, and consistency parameters of cream was found to be consistent over 90 days. Cream formulations showed net zone of growth inhibition in the range of 5.0-11.3 mm against bacteria and 4.3-7.6 mm against fungi. Primary irritation index was found to be between 0.38 and1.05. Conclusively stable, consistent, non-irritant, enriched antiseptic basil oil cream formulations were developed utilizing HLB approach.

  5. A population memetics approach to cultural evolution in chaffinch song: meme diversity within populations. (United States)

    Lynch, A; Baker, A J


    We investigated cultural evolution in populations of common chaffinches (Fringilla coelebs) in the Atlantic islands (Azores, Madeira, Canaries) and neighboring continental regions (Morocco, Iberia) by employing a population memetics approach. To quantify variability within populations, we used the concept of a song meme, defined as a single syllable or a series of linked syllables capable of being transmitted. The frequency distribution of memes within populations generally fit a neutral model in which there is an equilibrium between mutation, migration, and drift, which suggests that memes are functionally equivalent. The diversity of memes of single syllables is significantly greater in the Azores compared to all other regions, consistent with higher population densities of chaffinches there. On the other hand, memes of two to five syllables have greater diversity in Atlantic island and Moroccan populations compared to their Iberian counterparts. This higher diversity emanates from a looser syntax and increased recombination in songs, presumably because of relaxed selection for distinctive songs in these peripheral and depauperate avifaunas. We urge comparative population memetic studies of other species of songbirds and predict that they will lead to a formulation of a general theory for the cultural evolution of bird song analogous to population genetics theory for biological traits.

  6. Different Regional Approaches to Cultural diversity Interpreting the Belgian Cultural Diversity Policy Paradox

    Directory of Open Access Journals (Sweden)

    Ilke Adam


    Full Text Available In Belgium, the authority over cultural diversity policies resulting from immigration has been devolved from the central state to the regions since 1970. Consequently, Flanders and Francophone Belgium have progressively developed divergent policy tools. By describing the divergent evolution of Francophone and Flemish cultural diversity policies, our paper demonstrates the existence of a “Belgian Cultural Diversity Paradox”, namely the existence of more multicultural minority rights in the region that has most experienced electoral success by an extreme-right anti-immigrant party (Flanders, and a more colour blind and radical secular approach in the region where anti-immigrant politicization is barely a factor (Francophone Belgium. This finding is counter-intuitive because an important strand of immigrant policy research has emphasized the relationship between the politicization of immigration and restrictive immigrant citizenship rights. Our paper demonstrates that the different degrees of politicization of immigration in Flanders and Francophone Belgium cannot fully account for divergent cultural diversity policies. By insisting on the historical path dependency of the linguistic and religious cleavages in Belgium and their overlap, this paper offers an addendum to the politicization approach. The historical linguistic and religious differences of the Belgian regions clearly mediate the impact of the politicization of immigration on both sides of the linguistic border.

  7. ENSI Approach to Oversight of Safety Culture

    International Nuclear Information System (INIS)

    Humbel Haag, Claudia


    Claudia Humbel Haag presented developments in ENSI approach to safety culture oversight. ENSI has developed a definition/understanding of Safety Culture and a concept of how to perform oversight of Safety Culture. ENSI defines safety culture in the following way: Safety Culture comprises the behaviour, world views (in the sense of conceptualisations of reality and explanation models), values (in the sense of aims and evaluation scales), and features of the physical environment (specifically, the nuclear power plant and the documents used) which are shared by many members of an organization, in as much as these are of significance to nuclear safety. A model of the accessibility of safety culture was presented ranging from the observable (external aspects of safety culture), to aspects that are accessible by asking questions, through to aspects that are not accessible (internal part of safety culture). ENSI considers observable aspects through the existing systematic safety assessment compliance program. Aspects that are observable by asking questions will be addressed by additional oversight activities outside the systematic assessment program. Aspects that are not accessible are addressed by helping the licensee to re-think its safety culture through proactive discussions on safety culture. Reports are issued to the licensee on assumptions and observations identified through the discussions. The conclusions of the presentation emphasised the importance of basing any interventions in this area on a solid understanding of the concept of safety culture. ENSI safety culture oversight principles were also described. These include licensee responsibility for safety, and the need for the regulator to critically review their own activities to ensure a positive influence on the licensee

  8. Optimization of a Culture Medium Using the Taguchi Approach for the Production of Microorganisms Active in Odorous Compound Removal

    Directory of Open Access Journals (Sweden)

    Krzysztof Makowski


    Full Text Available The aim of this work was to develop the composition of a medium for the cultivation of six microbial strains forming a deodorizing consortium: Pseudomonas fluorescens, Enterococcus faecium, Bacillus subtilis, Bacillus megaterium, Leuconostoc mesenteroides and Lactobacillus plantarum. The study focused on the optimization of a highly efficient culture medium composed of readily available components of plant origin to maximize microbial biomass yields, and to create a less expensive alternative to the commercial Tryptic Soy Broth medium (TSB. After preliminary efficiency screening of all tested media components, we selected four substrates for further optimization—soy protein concentrate (SPC, glucose or sucrose, and phosphate salts. The final concentrations of all components were fine-tuned using the Taguchi design for experiments according to an L9 array. Taguchi optimization led to formulation of a culture medium, which was approximately 5 times cheaper than TSB (depending on the components used. Consequently, microbial biomass yields were improved by up to 15-fold (1564%, depending on the strain. The results obtained in the laboratory experiments were then confirmed in pilot- (42 L and industrial- (300 L scale fermentation. Our results show that this method of using a parallel culture microbioreactor with the Taguchi approach can be recommended for optimization of culture media based on substrates of plant origin.

  9. A Lexical Approach to Identifying Dimensions of Organizational Culture (United States)

    Chapman, Derek S.; Reeves, Paige; Chapin, Michelle


    A comprehensive measure of organizational culture was developed using a lexical approach, a method typically employed within the study of personality. 1761 adjectives were narrowed down and factor analyzed, which resulted in the identification of a nine factor solution to organizational culture, including the dimensions of: Innovative, Dominant, Pace, Friendly, Prestigious, Trendy, Corporate Social Responsibility, Traditional, and Diverse. Comprised of 135 adjectives most frequently used in describing organizational culture by current employees of several hundred organizations, the Lexical Organizational Culture Scale (LOCS) was found to predict employee commitment, job satisfaction, job search behaviors, and subjective fit better than earlier scales of organizational culture. PMID:29922200

  10. Teacher Perception of Cultural Difference in L2 Materials: Is Filtering Culture the Right Approach? (United States)

    Hermessi, Tarek


    With the emergence of the intercultural approach to L2 teaching, several studies investigated teachers' attitudes and beliefs concerning the cultural dimension of L2 teaching in different foreign language settings. This study explored teachers' perceptions of the relationship between teaching English and culture in Tunisia, an EFL setting where…

  11. Effectiveness of a consistently formulated diffusion-synthetic acceleration differencing approach

    International Nuclear Information System (INIS)

    Khalil, H.


    A consistently formulated differencing approach is applied to the diffusion-synthetic acceleration of discrete ordinates calculations based on various spatial differencing schemes. The diffusion ''coupling'' equations derived for each scheme are contrasted to conventional coupling relations and are shown to permit derivation of either point- or box-centered diffusion difference equations. The resulting difference equations are shown to be mathematically equivalent, in slab geometry, to equations derived by applying Larsen's four-step procedure to the S/sub 2/ equations. Fourier stability analysis of the acceleration method applied to slab model problems is used to demonstrate that, for any S/sub n/ differencing scheme (a) the upper bound on the spectral radius of the method occurs in the fine-mesh limit and equals that of the spatially continuous case (0.22466), and (b) the spectral radius decreases with increasing mesh size to an asymptotic value <0.13135. This model problem performance is somewhat superior to that of Larsen's approach, for which the spectral radius is bounded by 0.25 in the wide-mesh limit. Numerical results of multidimensional, heterogeneous, scattering-dominated problems are also presented to demonstrate the rapid convergence of accelerated discrete ordinates calculations using various spatial differencing schemes

  12. Modular co-culture engineering, a new approach for metabolic engineering. (United States)

    Zhang, Haoran; Wang, Xiaonan


    With the development of metabolic engineering, employment of a selected microbial host for accommodation of a designed biosynthetic pathway to produce a target compound has achieved tremendous success in the past several decades. Yet, increasing requirements for sophisticated microbial biosynthesis call for establishment and application of more advanced metabolic engineering methodologies. Recently, important progress has been made towards employing more than one engineered microbial strains to constitute synthetic co-cultures and modularizing the biosynthetic labor between the co-culture members in order to improve bioproduction performance. This emerging approach, referred to as modular co-culture engineering in this review, presents a valuable opportunity for expanding the scope of the broad field of metabolic engineering. We highlight representative research accomplishments using this approach, especially those utilizing metabolic engineering tools for microbial co-culture manipulation. Key benefits and major challenges associated with modular co-culture engineering are also presented and discussed. Copyright © 2016 International Metabolic Engineering Society. Published by Elsevier Inc. All rights reserved.

  13. The "Biogenetic Law" in zoology: from Ernst Haeckel's formulation to current approaches. (United States)

    Olsson, Lennart; Levit, Georgy S; Hoßfeld, Uwe


    150 years ago, in 1866, Ernst Haeckel published a book in two volumes called "Generelle Morphologie der Organismen" (General Morphology of Organisms) in which he formulated his biogenetic law, famously stating that ontogeny recapitulates phylogeny. Here we describe Haeckel's original idea and follow its development in the thinking of two scientists inspired by Haeckel, Alexei Sewertzoff and Adolf Naef. Sewertzoff and Naef initially approached the problem of reformulating Haeckel's law in similar ways, and formulated comparable hypotheses at a purely descriptive level. But their theoretical viewpoints were crucially different. While Sewertzoff laid the foundations for a Darwinian evolutionary morphology and is regarded as a forerunner of the Modern Synthesis, Naef was one of the most important figures in 'idealistic morphology', usually seen as a type of anti-Darwinism. Both Naef and Sewertzoff aimed to revise Haeckel's biogenetic law and came to comparable conclusions at the empirical level. We end our review with a brief look at the present situation in which molecular data are used to test the "hour-glass model", which can be seen as a modern version of the biogenetic law.

  14. Estimating the gasoline components and formulations toxicity to microalgae (Tetraselmis chuii) and oyster (Crassostrea rhizophorae) embryos: An approach to minimize environmental pollution risk

    International Nuclear Information System (INIS)

    Paixao, J.F.; Nascimento, I.A.; Pereira, S.A.; Leite, M.B.L.; Carvalho, G.C.; Silveira, J.S.C.; Reboucas, M.; Matias, G.R.A.; Rodrigues, I.L.P.


    Even though petrochemical contamination frequently occurs in the form of oil spills, it is thought that a greater danger to coastal habitats is posed by chronic petrochemical toxicity associated with urban run-off, in which gasoline water-soluble-fraction (WSF) plays an important role. The hypothesis of the entrepreneurs, who were associated to the scientists uncharged of this research, was that recycled petrochemical waste may provide different gasoline formulations, having different toxic properties; the correlation between the gasoline formulations and their components' toxicological effects might contribute to the reformulation of the products, in such a way that the gasoline generated could be less toxic and less harmful to the environment. The aim of this research was to determine the toxic effects of 14 different types of gasoline (formulated, in accordance with National Petroleum Agency standards, from petrochemical waste), on Tetraselmis chuii (microalgae culture) and Crassostrea rhizophorae (embryos). Microalgae and oyster embryos were exposed to different gasoline formulations water-soluble fractions (WSF) at a range of concentrations (0%, 4.6%, 10.0%, 22.0%, 46.0%, and 100%), for 96 and 24 h, respectively. The tests were carried out under controlled conditions. End-points have been CI50-96h (concentration causing 50% growth inhibition in microalgae cultures) and EC50-24h (concentration causing abnormalities on 50% of the exposed embryos). Through these procedures, gasoline formulations, which represent the lowest environmental risk, were selected. Bioassays carried out on the 8 different gasoline components aimed to correlate gasoline toxicity with the toxic potential of its components. The analysis of principal components showed that the C9DI, a mixture of aromatic hydrocarbons of 9 carbon atoms, had the highest level of toxic potential, followed by C9S (a mixture of aromatics with 9-11 carbon atoms) and heavy naphtha. The results showed gasoline

  15. A Simulation-Based Approach to Training Operational Cultural Competence (United States)

    Johnson, W. Lewis


    Cultural knowledge and skills are critically important for military operations, emergency response, or any job that involves interaction with a culturally diverse population. However, it is not obvious what cultural knowledge and skills need to be trained, and how to integrate that training with the other training that trainees must undergo. Cultural training needs to be broad enough to encompass both regional (culture-specific) and cross-cultural (culture-general) competencies, yet be focused enough to result in targeted improvements in on-the-job performance. This paper describes a comprehensive instructional development methodology and training technology framework that focuses cultural training on operational needs. It supports knowledge acquisition, skill acquisition, and skill transfer. It supports both training and assessment, and integrates with other aspects of operational skills training. Two training systems will be used to illustrate this approach: the Virtual Cultural Awareness Trainer (VCAT) and the Tactical Dari language and culture training system. The paper also discusses new and emerging capabilities that are integrating cultural competence training more strongly with other aspects of training and mission rehearsal.

  16. Development of a vinasse culture medium for plant tissue culture

    International Nuclear Information System (INIS)

    Silva, A.L.L.D.; Gollo, L.


    Vinasse is the main pollutant (effluent) obtained from the distillation of sugarcane in the production of fuel alcohol. However, this residue is rich in nutrients that are required by plants. We developed a new culture medium using vinasse for the In vitro propagation of an orchid. The vinasse was treated (decanted and filtered), and the nutrients were determined and quantified. Different formulations using vinasse were tested for an In vitro culture. The vinasse dilutions demonstrated a good buffering effect. The ideal vinasse dilution for media formulation was 2.5%. The best KC formulations with vinasse were KCV1 and KCV5. Compared to KC medium, these formulations demonstrated similar results for In vitro multiplication, with the exception of protocorm-like body number, which was inferior in the vinasse formulations. Conversely, for In vitro elongation and rooting, these vinasse media were superior to KC medium. KC medium promotes a low rooting rate (8%) compared to 68 and 100% obtained by KCV1 and KCV5, respectively. Moreover, plantlets cultured on KC medium become protocorm-like body clusters, which impeded the acclimatization of these explants. Plantlets elongated and rooted on KCV1 and KCV5 were successfully acclimatized with a 91% survival rate for both KC vinasse formulations. This study shows the great potential of this technology as a rational alternative to vinasse disposal and adds value to what is currently considered a waste product. (author)

  17. Cultural sensitivity and supportive expressive psychotherapy: an integrative approach to treatment. (United States)

    White, Tracela M; Gibbons, Mary Beth Connolly; Schamberger, Megan


    Cultural sensitivity is a concept that has become increasingly important in psychotherapy research and practice. In response to the growing ethnic minority population and the increased demand for psychological services among minority clients, many therapists and researchers have attempted to identify competencies and guidelines for providing culturally sensitive approaches to treatment. However, many cultural sensitivity concepts are theoretical and have rarely been integrated into an established psychotherapeutic framework. The purpose of this manuscript is to operationalize the concepts of cultural sensitivity into specific therapeutic techniques using a manual-guided Supportive Expressive Psychotherapy approach. Developing these strategies may serve to further assist therapists with the delivery of mental health services to ethnic minority clients.

  18. The Ritz - Sublaminate Generalized Unified Formulation approach for piezoelectric composite plates (United States)

    D'Ottavio, Michele; Dozio, Lorenzo; Vescovini, Riccardo; Polit, Olivier


    This paper extends to composite plates including piezoelectric plies the variable kinematics plate modeling approach called Sublaminate Generalized Unified Formulation (SGUF). Two-dimensional plate equations are obtained upon defining a priori the through-thickness distribution of the displacement field and electric potential. According to SGUF, independent approximations can be adopted for the four components of these generalized displacements: an Equivalent Single Layer (ESL) or Layer-Wise (LW) description over an arbitrary group of plies constituting the composite plate (the sublaminate) and the polynomial order employed in each sublaminate. The solution of the two-dimensional equations is sought in weak form by means of a Ritz method. In this work, boundary functions are used in conjunction with the domain approximation expressed by an orthogonal basis spanned by Legendre polynomials. The proposed computational tool is capable to represent electroded surfaces with equipotentiality conditions. Free-vibration problems as well as static problems involving actuator and sensor configurations are addressed. Two case studies are presented, which demonstrate the high accuracy of the proposed Ritz-SGUF approach. A model assessment is proposed for showcasing to which extent the SGUF approach allows a reduction of the number of unknowns with a controlled impact on the accuracy of the result.

  19. The Cultural of Production and Career in the Danish film Industry

    DEFF Research Database (Denmark)

    Mathieu, Chris

    This chapter explores some of the central cultural tenets of career and film making among elite members of the Danish film industry, or what is less than elegantly and somewhat grammatically incorrectly referred to as ‘the cultural of production and career’ in the title of this chapter....... The theoretical reasons for this formulation is to train focus on the ideational dimensions of culture in the Danish film industry, especially as refracted through reflections on work and career by film workers. In this sense the approach, though less inclusive and ambitious, resembles Caldwell’s interest...

  20. Formulation of Higher Education Institutional Strategy Using Operational Research Approaches (United States)

    Labib, Ashraf; Read, Martin; Gladstone-Millar, Charlotte; Tonge, Richard; Smith, David


    In this paper a framework is proposed for the formulation of a higher education institutional (HEI) strategy. This work provides a practical example, through a case study, to demonstrate how the proposed framework can be applied to the issue of formulation of HEI strategy. The proposed hybrid model is based on two operational research…

  1. How Cultural Knowledge Shapes Core Design Thinking

    DEFF Research Database (Denmark)

    Clemmensen, Torkil; Ranjan, Apara; Bødker, Mads


    The growing trend of co-creation and co-design in cross-cultural design teams presents challenges for the design thinking process. We integrate two frameworks, one on reasoning patterns in design thinking, the other on the dynamic constructivist theory of culture, to propose a situation specific...... framework for the empirical analysis of design thinking in cross-cultural teams. We illustrate the framework with a qualitative analysis of 16 episodes of design related conversations, which are part of a design case study. The results show that cultural knowledge, either as shared by the cross......-cultural team or group specific knowledge of some team members, shape the reasoning patterns in the design thinking process across all the 16 episodes. Most of the design discussions were approached by the designers as problem situations that were formulated in a backward direction, where the value to create...

  2. Cultural Elements and Universality in the Process of Globalization : A Tentative Approach to a Theorization of Culture in sociology


    丸山, 哲央


    "The main purpose of this paper is to propose a conceptual scheme for the analysis of cultural globalization in accordance with the Parsonian notion of culture, and to point out some problematic issues caused by cultural globalization: the unbalanced development of cultural elements and the prevalence of the pseudo universality of a dominant particular culture. With respect to the recent trend of ‘cultural turn’ in social sciences, this is a tentative approach to a theorization of culture as ...

  3. A socio-cultural instrumental approach to emotion regulation: Culture and the regulation of positive emotions. (United States)

    Ma, Xiaoming; Tamir, Maya; Miyamoto, Yuri


    We propose a sociocultural instrumental approach to emotion regulation. According to this approach, cultural differences in the tendency to savor rather than dampen positive emotions should be more pronounced when people are actively pursuing goals (i.e., contexts requiring higher cognitive effort) than when they are not (i.e., contexts requiring lower cognitive efforts), because cultural beliefs about the utility of positive emotions should become most relevant when people are engaging in active goal pursuit. Four studies provided support for our theory. First, European Americans perceived more utility and less harm of positive emotions than Japanese did (Study 1). Second, European Americans reported a stronger relative preference for positive emotions than Asians, but this cultural difference was larger in high cognitive effort contexts than in moderate or low cognitive effort contexts (Study 2). Third, European Americans reported trying to savor rather than dampen positive emotions more than Asians did when preparing to take an exam, a typical high cognitive effort context (Studies 3-4), but these cultural differences were attenuated when an exam was not expected (Study 3) and disappeared when participants expected to interact with a stranger (Study 4). These findings suggest that cultural backgrounds and situational demands interact to shape how people regulate positive emotions. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  4. Regulatory Oversight of Safety Culture in Finland: A Systemic Approach to Safety

    International Nuclear Information System (INIS)

    Oedewald, P.; Väisäsvaara, J.


    In Finland the Radiation and Nuclear Safety Authority STUK specifies detailed regulatory requirements for good safety culture. Both the requirements and the practical safety culture oversight activities reflect a systemic approach to safety: the interconnections between the technical, human and organizational factors receive special attention. The conference paper aims to show how the oversight of safety culture can be integrated into everyday oversight activities. The paper also emphasises that the scope of the safety culture oversight is not specific safety culture activities of the licencees, but rather the overall functioning of the licence holder or the new build project organization from safety point of view. The regulatory approach towards human and organizational factors and safety culture has evolved throughout the years of nuclear energy production in Finland. Especially the recent new build projects have highlighted the need to systematically pay attention to the non-technical aspects of safety as it has become obvious how the HOF issues can affect the design processes and quality of construction work. Current regulatory guides include a set of safety culture related requirements. The requirements are binding to the licence holders and they set both generic and specific demands on the licencee to understand, monitor and to develop safety culture of their own organization but also that of their supplier network. The requirements set for the licence holders has facilitated the need to develop the regulator’s safety culture oversight practices towards a proactive and systemic approach.

  5. Quality by design approach for optimizing the formulation and physical properties of extemporaneously prepared orodispersible films. (United States)

    Visser, J Carolina; Dohmen, Willem M C; Hinrichs, Wouter L J; Breitkreutz, Jörg; Frijlink, Henderik W; Woerdenbag, Herman J


    The quality by design (QbD) approach was applied for optimizing the formulation of extemporaneously prepared orodispersible films (ODFs) using Design-Expert® Software. The starting formulation was based on earlier experiments and contained the film forming agents hypromellose and carbomer 974P and the plasticizer glycerol (Visser et al., 2015). Trometamol and disodium EDTA were added to stabilize the solution. To optimize this formulation a quality target product profile was established in which critical quality attributes (CQAs) such as mechanical properties and disintegration time were defined and quantified. As critical process parameters (CPP) that were evaluated for their effect on the CQAs the percentage of hypromellose and the percentage of glycerol as well as the drying time were chosen. Response surface methodology (RMS) was used to evaluate the effects of the CPPs on the CQAs of the final product. The main factor affecting tensile strength and Young's modulus was the percentage of glycerol. Elongation at break was mainly influenced by the drying temperature. Disintegration time was found to be sensitive to the percentage of hypromellose. From the results a design space could be created. As long as the formulation and process variables remain within this design space, a product is obtained with desired characteristics and that meets all set quality requirements. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. A Frame Analysis Approach To Cross-Cultural Television Advertising


    Noel M. Murray


    The role of visuals in advertising research is examined. An argument is developed to support a theory of frame analysis for cross-cultural television advertising. Frame analysis is explained and commercials from Japan and the Dominican Republic are used to illustrate application of the theory. It is hoped that frame analysis will supplement content analysis as a methodological approach to cross-cultural television advertising.

  7. Innovative Modelling Approach of Safety Culture Assessment in Nuclear Power Plant

    International Nuclear Information System (INIS)

    Ahn, N.


    A culture is commonly defined as the shared set of norms and values that govern appropriate individual behavior. Safety culture is the subset of organizational culture that reflects the general attitude and approaches to safety and risk management. While safety is sometimes narrowly defined in terms of human death and injury, we use a more inclusive definition that also considers mission loss as a safety problem and is thus applicable to nuclear power plants and missions. The recent accident reports and investigations of the nuclear power plant mission failures (i.e., TMI, Chernobyl, and Fukushima) point to safety cultural problems in nuclear power plants. Many assessment approaches have been developed by organizations such as IAEA and INPO based on the assessment of parameters at separate levels — individuals, groups, and organizations.


    Directory of Open Access Journals (Sweden)

    Lyudmila V. Astakhova


    Full Text Available Introduction: problems of cultural competence development among higher school students are becoming increasingly important against a decline in a cultural level of an individual in a post-industrial society. Their relevance is determined by low level of effectiveness in the use of competence-based approach in higher education, debatable nature of the culture concept in scholarship, and evolution of axiological dominants in different cultures, specificity of dominant values in post-industr ial culture. Materials and Methods: the author uses a competence-based approach to determine the cultural competence of students. A cultural approach is applied to determine various approaches to culture. A capital approach is established as the approach enabling to take into account the cultural and axiological dominants of post-industrial society. Analytic-synthetic methods are used in the search and analysis of literature on the topic; the method of comparative analysis in the determination of essence of concepts of cultural competence: method of sociological survey to discover the level of cultural competence of graduates. Results: the sociological survey of employers revealed the insufficient level of cultural competence among graduates; the concept of cultural competence in pedagogical science was examined; the limitations of approaches to this concept were identified, the author’s definition of cultural competence of personality in a postindustrial society is substantiated. Based on the author’s informed definition of cultural competence, as well as the notion of cultural capital, the author substantiates the definition of “cultural-capital competence of a student in a post-industrial society” as a structural part of his / her cultural competence, which takes into account the requirements of a post-industrial society. Discussion and Conclusions: given the evolution of value priorities in a post-industrial culture, the author substantiates the

  9. Linear programming: an alternative approach for developing formulations for emergency food products. (United States)

    Sheibani, Ershad; Dabbagh Moghaddam, Arasb; Sharifan, Anousheh; Afshari, Zahra


    To minimize the mortality rates of individuals affected by disasters, providing high-quality food relief during the initial stages of an emergency is crucial. The goal of this study was to develop a formulation for a high-energy, nutrient-dense prototype using linear programming (LP) model as a novel method for developing formulations for food products. The model consisted of the objective function and the decision variables, which were the formulation costs and weights of the selected commodities, respectively. The LP constraints were the Institute of Medicine and the World Health Organization specifications of the content of nutrients in the product. Other constraints related to the product's sensory properties were also introduced to the model. Nonlinear constraints for energy ratios of nutrients were linearized to allow their use in the LP. Three focus group studies were conducted to evaluate the palatability and other aspects of the optimized formulation. New constraints were introduced to the LP model based on the focus group evaluations to improve the formulation. LP is an appropriate tool for designing formulations of food products to meet a set of nutritional requirements. This method is an excellent alternative to the traditional 'trial and error' method in designing formulations. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  10. Flow Formulations for Curriculum-based Course Timetabling

    DEFF Research Database (Denmark)

    Bagger, Niels-Christian Fink; Kristiansen, Simon; Sørensen, Matias


    lower bound on one data instance in the benchmark data set from the second international timetabling competition. Regarding upper bounds, the formulation based on the minimum cost flow problem performs better on average than other mixed integer programming approaches for the CTT.......In this paper we present two mixed-integer programming formulations for the Curriculum based Course Timetabling Problem (CTT). We show that the formulations contain underlying network structures by dividing the CTT into two separate models and then connect the two models using flow formulation...... techniques. The first mixed-integer programming formulation is based on an underlying minimum cost flow problem, which decreases the number of integer variables significantly and improves the performance compared to an intuitive mixed-integer programming formulation. The second formulation is based...

  11. Cross-cultural adaptation of instruments assessing breastfeeding determinants: a multi-step approach (United States)


    Background Cross-cultural adaptation is a necessary process to effectively use existing instruments in other cultural and language settings. The process of cross-culturally adapting, including translation, of existing instruments is considered a critical set to establishing a meaningful instrument for use in another setting. Using a multi-step approach is considered best practice in achieving cultural and semantic equivalence of the adapted version. We aimed to ensure the content validity of our instruments in the cultural context of KwaZulu-Natal, South Africa. Methods The Iowa Infant Feeding Attitudes Scale, Breastfeeding Self-Efficacy Scale-Short Form and additional items comprise our consolidated instrument, which was cross-culturally adapted utilizing a multi-step approach during August 2012. Cross-cultural adaptation was achieved through steps to maintain content validity and attain semantic equivalence in the target version. Specifically, Lynn’s recommendation to apply an item-level content validity index score was followed. The revised instrument was translated and back-translated. To ensure semantic equivalence, Brislin’s back-translation approach was utilized followed by the committee review to address any discrepancies that emerged from translation. Results Our consolidated instrument was adapted to be culturally relevant and translated to yield more reliable and valid results for use in our larger research study to measure infant feeding determinants effectively in our target cultural context. Conclusions Undertaking rigorous steps to effectively ensure cross-cultural adaptation increases our confidence that the conclusions we make based on our self-report instrument(s) will be stronger. In this way, our aim to achieve strong cross-cultural adaptation of our consolidated instruments was achieved while also providing a clear framework for other researchers choosing to utilize existing instruments for work in other cultural, geographic and population

  12. Influence of the saline formulation in the conservation of in vitro plants of sugar cane

    Directory of Open Access Journals (Sweden)

    Leyanis García-Águila


    Full Text Available The present work had as aim to determine the saline formulation and its ideal concentration, as well as the culture temperature for the conservation of in vitro plants of sugar cane fran the variaty somaclonal IBP 87-100. Different concentrations of the saline formulations were studied MS (25, 50, 75, 100% and White (75, 100, 125% associated with two culture temperatures, 18 and 26 ±2ºC. The percentage of survival and the physiological condition of the plants during the period of conservation were decided. The conservation of the plants during six consecutive months was obtained as result when using the formulation MS reduced to 25 and 50%, associated with a culture temperature at 18ºC. This way the growth of the plants was slow and minor the physiological hurts, with values of survival between 58.3 and 69.2%. Whereas the formulation White did not favour the prolongation of conservation period and the plants only could be supported during two months with more than 50% of the foliate area dried. This behaviour could response due to the low levels of nitrogen that contains this formulation. Key words: culture temperature, in vitro conservation, saline concentration, survival

  13. Approaches to learning among occupational therapy undergraduate students: A cross-cultural study. (United States)

    Brown, Ted; Fong, Kenneth N K; Bonsaksen, Tore; Lan, Tan Hwei; Murdolo, Yuki; Gonzalez, Pablo Cruz; Beng, Lim Hua


    Students may adopt various approaches to academic learning. Occupational therapy students' approaches to study and the impact of cultural context have not been formally investigated to date. To examine the approaches to study adopted by undergraduate occupational therapy students from four different cultural settings. 712 undergraduate occupational therapy students (n = 376 from Australia, n = 109 from Hong Kong, n = 160 from Norway and n = 67 from Singapore) completed the Approaches and Study Skills Inventory for Students (ASSIST). A one-way analysis of variance (ANOVA) was conducted to compare the ASSIST subscales for the students from the four countries. Post-hoc comparisons using the Tukey HSD test indicated that the mean scores for the strategic approach were significantly different between Australia and the other three countries. The mean scores for the surface approach were significantly different between Australia and Hong Kong, and Hong Kong and Norway. There were no significant differences between the deep approach to studying between Australia, Norway, Singapore and Hong Kong. Culture and educational context do appear to impact the approaches to study adopted by undergraduate occupational therapy students. Academic and practice educators need to be cognizant of what approaches to studying the students they work with adopt.

  14. A New Resistance Formulation for Carbon Nanotubes

    Directory of Open Access Journals (Sweden)

    Ji-Huan He


    Full Text Available A new resistance formulation for carbon nanotubes is suggested using fractal approach. The new formulation is also valid for other nonmetal conductors including nerve fibers, conductive polymers, and molecular wires. Our theoretical prediction agrees well with experimental observation.

  15. Researcher’s Academic Culture in the Educational Space of the University: Linguo-Axiological Approach

    Directory of Open Access Journals (Sweden)

    Olena Semenog


    Full Text Available The article is devoted to the nature of the concepts “classic University”, “cultural and educational space of the University”, “research activity of future professional”, “researcher’s academic culture” and approach to academic culture as the basis of research culture in a university. It is defined that the concept of academic culture is complex. We are talking in general about the culture at the university, values, traditions, norms, rules of scientific research, and the scientific language culture, the culture of spirituality and morality, the culture of communication between science tutors and students, a culture of unique pedagogical action of master and his social, moral responsibility for the studying results. The formation of academic culture and own style, is better to develop on the positions of personal-activity, competence, axiological, cultural, acmeological approaches.

  16. Culture of health of a person as a part of physical culture


    A.P. Khalajtsan


    Purpose: to determine the general concepts of the theory and methods of physical education. On the basis of their form defining the components of physical culture and personality reflect the place of culture health of individuals among these components. Material: processed more than 40 references. Results: a definition of generalizing concepts of "culture", "health", "physical culture", "culture of health" formulated defining components of physical culture personality: health culture personal...

  17. The Issue of Compatibility between Cultural Integrity and Economic Development among Native American Tribes. (United States)

    Smith, Dean Howard


    Argues that economic development on American Indian reservations can strengthen a tribe's ability to maintain its culture if all development plans are formulated with consideration for their total societal impact. Discusses holistic approaches to development and business management, spiritual concerns, implications for higher education, and…

  18. Aggregation factor analysis for protein formulation by a systematic approach using FTIR, SEC and design of experiments techniques. (United States)

    Feng, Yan Wen; Ooishi, Ayako; Honda, Shinya


    A simple systematic approach using Fourier transform infrared (FTIR) spectroscopy, size exclusion chromatography (SEC) and design of experiments (DOE) techniques was applied to the analysis of aggregation factors for protein formulations in stress and accelerated testings. FTIR and SEC were used to evaluate protein conformational and storage stabilities, respectively. DOE was used to determine the suitable formulation and to analyze both the main effect of single factors and the interaction effect of combined factors on aggregation. Our results indicated that (i) analysis at a low protein concentration is not always applicable to high concentration formulations; (ii) an investigation of interaction effects of combined factors as well as main effects of single factors is effective for improving conformational stability of proteins; (iii) with the exception of pH, the results of stress testing with regard to aggregation factors would be available for suitable formulation instead of performing time-consuming accelerated testing; (iv) a suitable pH condition should not be determined in stress testing but in accelerated testing, because of inconsistent effects of pH on conformational and storage stabilities. In summary, we propose a three-step strategy, using FTIR, SEC and DOE techniques, to effectively analyze the aggregation factors and perform a rapid screening for suitable conditions of protein formulation. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. A situational approach to the measurement of safety culture

    International Nuclear Information System (INIS)

    Semmer, N.; Regennass, A.


    Values and social norms are the main target of most approaches to the study of safety culture and many existing survey methodologies directly ask for these norms and values. However, a number of considerations point to the dangers of limiting the evaluation of safety culture to the analysis of these responses. Therefore the necessity is stressed to also consider how actual situations activate norms and behaviours. This relates to the fact that in any given situation both aspects of the appraisal of reality are present: the objective definition of the situation and its personal evaluation. The latter not only reflects the ''official'' norms and values but also ''basic underlying assumptions''. The situational approach introduced in this paper confronts people with situations which contain a dilemma with conflicting social norms and where various costs and benefits are associated with different types of behaviour. In addition, the prerequisites and limitations of the situational approach are discussed. (author). 9 refs, 1 fig

  20. A systems biology framework for pathway level culture media engineering: pplication to Pichia pastoris cultures


    Ferreira, Ana Raquel Santos


    Dissertação para obtenção do Grau de Doutor em Engenharia Química e Bioquímica Culture media (CM) formulations contain hundreds of ingredients in aqueous solutions that may be involved in complex interactions in the same or competing pathways within the cell. This thesis proposes a new methodology for determining the optimal composition of CM that migrates from an empirical to a mechanistic or hybrid mechanistic CM development approach. A framework consisting in the execution of an a...

  1. Mass Media and Religious Culture of the Audiences; Suggesting a Useful Approach to Media Productions for Children

    Directory of Open Access Journals (Sweden)

    Nasser Bahonar


    Full Text Available The religious program of mass media exclusively produced for children have had a significant growth in recent years. The artistic expression of stories related to the life of the great prophets and to the history of Islam as well as taking advantage of theatrical literature in religious occasions can herald successes in this neglected field. But, what is questionable in national religious policies in that why who are involved in the religious education of children whether in traditional media (family, mosques, religious communities, etc or in modern media (textbooks, press, radio and television do not follow an integrated and coherent policy based on a proved theoretical view of religious communications. In fact, this question results from the same old opposition between audience-oriented and media-oriented approaches in communications as well as the opposition between cognitivism and other approaches in psychology. The findings of the field of study conducted by the author along with psychological achievements of cognitivism in human communications and cultural audience-oriented approaches, especially reception theory in mass communications can solve some existing difficulties in the formulation of religious messages. Drawing upon the above mentioned theoretical schools, this article tries to introduce a useful approach to producing religious programs for children and describes the main tasks of mass media in this field accordingly.

  2. Culture-sensitive neural substrates of human cognition: a transcultural neuroimaging approach. (United States)

    Han, Shihui; Northoff, Georg


    Our brains and minds are shaped by our experiences, which mainly occur in the context of the culture in which we develop and live. Although psychologists have provided abundant evidence for diversity of human cognition and behaviour across cultures, the question of whether the neural correlates of human cognition are also culture-dependent is often not considered by neuroscientists. However, recent transcultural neuroimaging studies have demonstrated that one's cultural background can influence the neural activity that underlies both high- and low-level cognitive functions. The findings provide a novel approach by which to distinguish culture-sensitive from culture-invariant neural mechanisms of human cognition.

  3. An approach for risk informed safety culture assessment for Canadian nuclear power stations

    International Nuclear Information System (INIS)

    Nelson, W.R.


    One of the most important components of effective safety and risk management for nuclear power stations is a healthy safety culture. DNV has developed an approach for risk informed safety culture assessment that combines two complementary paradigms for safety and risk management: loss prevention - for preventing and intervening in accidents; and critical function management - for achieving safety and performance goals. Combining these two paradigms makes it possible to provide more robust systems for safety management and to support a healthy safety culture. This approach is being applied to safety culture assessment in partnership with a Canadian nuclear utility. (author)

  4. Improvement of mammalian cell culture performance through surfactant enabled concentrated feed media. (United States)

    Hossler, Patrick; McDermott, Sean; Racicot, Christopher; Fann, John C H


    The design of basal and feed media in mammalian cell culture is paramount towards ensuring acceptable upstream process performance in various operation modes, especially fed-batch culture. Mammalian cell culture media designs have evolved from the classical formulations designed by Eagle and Ham, to today's formulations designed from continuous improvement and statistical frameworks. Feed media is especially important for ensuring robust cell growth, productivity, and ensuring the product quality of recombinant therapeutics are within acceptable ranges. Numerous studies have highlighted the benefit of various media designs, supplements, and feed addition strategies towards the resulting cell culture process. In this work we highlight the use of a top-down level approach towards feed media design enabled by the use of select surfactants for the targeted enrichment of a chemically defined feed media. The use of the enriched media was able to improve product titers at g/L levels, without adversely impacting the growth of multiple Chinese Hamster Ovary cell lines or the product quality of multiple recombinant antibodies. © 2013 American Institute of Chemical Engineers.

  5. Interacting Successfully in Corporate Culture (Approaches and Practices). (United States)

    Southard, Sherry G.


    Argues that, to assume roles in corporate culture, business and technical communication students must understand corporate protocol discourse. Suggests that teachers can prepare students by providing exercises that increase student competence in navigating institutional politics. Concludes that such an approach will enable students to advance in…

  6. Individual, social, and cultural approaches to knowledge sharing

    Directory of Open Access Journals (Sweden)

    Widen, Gunilla


    Full Text Available Workplace knowledge sharing is a complex process and there are a large number of studies in the area. In this article three theoretical approaches in library and information science are used to discuss knowledge sharing in the workplace. The approaches are information behavior, social capital, and information culture, and they bring important insights that need to be considered from a holistic management point of view when it comes to knowledge sharing. The individual's relation to different levels of context is important, meaning both in relation to work roles, work tasks, situations, organizational structures, and culture. The frameworks also shed light on where and how knowledge sharing activities are present in the organization. From a knowledge management point of view, it is important to acknowledge that when knowledge is valued, there is also an awareness of the knowledge sharing activities. Also, in addition to more traditional views of context, the frameworks bring forward different views on context, such as time and space as contextual factors.

  7. Cultural Distance-Aware Service Recommendation Approach in Mobile Edge Computing

    Directory of Open Access Journals (Sweden)

    Yan Li


    Full Text Available In the era of big data, traditional computing systems and paradigms are not efficient and even difficult to use. For high performance big data processing, mobile edge computing is emerging as a complement framework of cloud computing. In this new computing architecture, services are provided within a close proximity of mobile users by servers at the edge of network. Traditional collaborative filtering recommendation approach only focuses on the similarity extracted from the rating data, which may lead to an inaccuracy expression of user preference. In this paper, we propose a cultural distance-aware service recommendation approach which focuses on not only the similarity but also the local characteristics and preference of users. Our approach employs the cultural distance to express the user preference and combines it with similarity to predict the user ratings and recommend the services with higher rating. In addition, considering the extreme sparsity of the rating data, missing rating prediction based on collaboration filtering is introduced in our approach. The experimental results based on real-world datasets show that our approach outperforms the traditional recommendation approaches in terms of the reliability of recommendation.

  8. Leadership, Peer Relationship, and Transformational Organizational Culture: A Relational Approach to a Taiwan College Music Faculty Sample (United States)

    Ji, Chang-Ho C.; Chuang, Ching-Mien


    This paper explores how leadership and peer relation relate to the propensity of college music departments to develop transformational organizational culture. Our theory of relational leadership and peer relation has initially allowed us to formulate expectations for the affirmative impacts of professional and personal leadership and peer relation…

  9. Culture-bound syndrome and a culturally sensitive approach: from a viewpoint of medical anthropology. (United States)

    Shimoji, A; Miyakawa, T


    Some aspects of the culture-bound syndrome are presented for discussion. From the psychiatric and medical anthropological viewpoints, kamidaari is described as an initiatory illness for seeing a shaman, and focus on clinical realities developing between different therapeutic subcultures in the same culture and the complementary practices of two epistemological ones, namely, the shamanistic and modern psychiatric system in the shamanistic climate. It is suggested that the culture-bound syndrome that reflects cultural influences on disease patterns and renders them difficult to place in a universal classificatory system should be seen as a vernacular bricolage or as tactics used by people within the web of their own local culture of origin. Therapists who treat patients in a cross-epistemological milieu should be aware of the subcultural-epistemological issues that may affect the clinical process. It should be recognized that, depending on the nature of a particular psychiatric crisis, the clinical encounter is straddling the boundaries of multiple clinical realities. At every stage in the clinical field, there is an intersection, consonance, or interruption of rejoinders in the open dialog by all those engaged in the clinical time. Aspects of climatic, culturally sensitive psychotherapy will be described, and the concept of the culture-bound syndrome will be reconsidered. Our approach could be seen as 'situation- and fudo-bound'.

  10. Evaluating the Properties of Poly(lactic-co-glycolic acid) Nanoparticle Formulations Encapsulating a Hydrophobic Drug by Using the Quality by Design Approach. (United States)

    Kozaki, Masato; Kobayashi, Shin-Ichiro; Goda, Yukihiro; Okuda, Haruhiro; Sakai-Kato, Kumiko


    We applied the Quality by Design (QbD) approach to the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticle formulations encapsulating triamcinolone acetonide, and the critical process parameters (CPPs) were identified to clarify the correlations between critical quality attributes and CPPs. Quality risk management was performed by using an Ishikawa diagram and experiments with a fractional factorial design (ANOVA). The CPPs for particle size were PLGA concentration and rotation speed, and the CPP for relative drug loading efficiency was the poor solvent to good solvent volume ratio. By assessing the mutually related factors in the form of ratios, many factors could be efficiently considered in the risk assessment. We found a two-factor interaction between rotation speed and rate of addition of good solvent by using a fractional factorial design with resolution V. The system was then extended by using a central composite design, and the results obtained were visualized by using the response surface method to construct a design space. Our research represents a case study of the application of the QbD approach to pharmaceutical development, including formulation screening, by taking actual production factors into consideration. Our findings support the feasibility of using a similar approach to nanoparticle formulations under development. We could establish an efficient method of analyzing the CPPs of PLGA nanoparticles by using a QbD approach.

  11. Characterising influences on safety culture in military aviation:a methodologically grounded approach


    Bennett, Anthea; Hellier, Elizabeth; Weyman, Andrew


    Historically, much effort has been expended in safety culture / climate research toward identifying a generic core set of components, predominately using the self-administered questionnaire approach. However, no stable unified model has emerged, and much of this research has taken a methodologically top-down approach to depicting organisational safety culture. In light of this, the benefits of qualitative exploration as a precursor to and foundation for the development of quantitative climate...

  12. Considering the cultural context in psychopathology formulations

    African Journals Online (AJOL)


    Mar 2, 2013 ... need to explore cultural conceptualisations of psychopathology is ... The review indicated that 29 literature sources were conceptual in design, suggesting a great need for more empirical research. This .... logy; universalism, relativism, abso ..... as philosophical systems include moral and political concerns.

  13. "A Completely New Approach" to Indigenous Cultural Heritage: Evaluating the Queensland Aboriginal Cultural Heritage Act

    Directory of Open Access Journals (Sweden)

    Mark E. O'Neill


    Full Text Available The Aboriginal Cultural Heritage Act 2003 challenged the hegemony that Western, archaeological methodologies has held over Indigenous cultural heritage in Australia. By choosing to relinquish state control and authority over cultural heritage in favour of the expertise of Indigenous people, the Act created a unique and innovative heritage policy. Over the 10 years the Act has been in force, it has seen a variety of approaches adopted as part of myriad projects. This has created a mature field of practice for investigation and analysis. This article examines and critiques the Act to determine its successes and weaknesses. In doing so, it offers opportunities for other policy-makers to consider as part of policy review.

  14. Culture and psychiatric diagnosis. (United States)

    Lewis-Fernández, Roberto; Aggarwal, Neil Krishan


    Since the publication of DSM-IV in 1994, neurobiologists and anthropologists have criticized the rigidity of its diagnostic criteria that appear to exclude whole classes of alternate illness presentations, as well as the lack of attention in contemporary psychiatric nosology to the role of contextual factors in the emergence and characteristics of psychopathology. Experts in culture and mental health have responded to these criticisms by revising the very process of diagnosis for DSM-5. Specifically, the DSM-5 Cultural Issues Subgroup has recommended that concepts of culture be included more prominently in several areas: an introductory chapter on Cultural Aspects of Psychiatric Diagnosis - composed of a conceptual introduction, a revised Outline for Cultural Formulation, a Cultural Formulation Interview that operationalizes this Outline, and a glossary on cultural concepts of distress - as well as material directly related to culture that is incorporated into the description of each disorder. This chapter surveys these recommendations to demonstrate how culture and context interact with psychiatric diagnosis at multiple levels. A greater appreciation of the interplay between culture, context, and biology can help clinicians improve diagnostic and treatment planning. Copyright © 2013 APA*

  15. Cross-cultural medical education: conceptual approaches and frameworks for evaluation. (United States)

    Betancourt, Joseph R


    Given that understanding the sociocultural dimensions underlying a patient's health values, beliefs, and behaviors is critical to a successful clinical encounter, cross-cultural curricula have been incorporated into undergraduate medical education. The goal of these curricula is to prepare students to care for patients from diverse social and cultural backgrounds, and to recognize and appropriately address racial, cultural, and gender biases in health care delivery. Despite progress in the field of cross-cultural medical education, several challenges exist. Foremost among these is the need to develop strategies to evaluate the impact of these curricular interventions. This article provides conceptual approaches for cross-cultural medical education, and describes a framework for student evaluation that focuses on strategies to assess attitudes, knowledge, and skills, and the impact of curricular interventions on health outcomes.

  16. Corporate culture of modern university: approaches to definition essence

    Directory of Open Access Journals (Sweden)

    N. V. Horbenko


    Full Text Available The role and importance of corporate culture of the university; found to relate concepts as «corporate culture» and «organizational culture» and discovered the last function: cognitive, value­education, communication, legal and regulatory, motivational, innovative and Stability; singled structural elements of corporate culture: artifacts, values, norms, goals and mission of the organization; and signs of the university as a corporation: nadorhanizatsiynist, polisub’yektnist, competitive environment, as the value of social identity formation and contrast to other organizations; noted that the characteristics of the corporate culture of the University is directly dependent on its public tasks, including such as meeting the needs of the individual in the intellectual, cultural and moral development through vocational education, science through research and creative activity of scientific and pedagogical staff training retraining and advanced training of employees with higher education, the formation of students’ citizenship, ability to work and life, spreading knowledge among the population, improving its educational and cultural level; indicated on the approaches to the definition of «corporate culture», including phenomenological and pragmatic, rational and genetic, and eksternalistskyy internalistskyy, guiding and limiting; peculiarities of formation and development of the corporate culture of the university in the context of competitiveness; the conclusions noted that the level of corporate culture depends not only on internal motivational guidance of employees of the University, but the resulting performance indicators ­ profitability, profitability and competitiveness.

  17. A Guttman-Based Approach to Identifying Cumulativeness Applied to Chimpanzee Culture


    Graber, RB; de Cock, DR; Burton, ML


    Human culture appears to build on itself-that is, to be to some extent cumulative. Whether this property is shared by culture in the common chimpanzee is controversial. The question previously has been approached, qualitatively (and inconclusively), by debating whether any chimpanzee culture traits have resulted from individuals building on one another's work ("ratcheting"). The fact that the chimpanzees at different sites have distinctive repertoires of traits affords a different avenue of a...

  18. An integrative approach to cultural competence in the psychiatric curriculum. (United States)

    Fung, Kenneth; Andermann, Lisa; Zaretsky, Ari; Lo, Hung-Tat


    As it is increasingly recognized that cultural competence is an essential quality for any practicing psychiatrist, postgraduate psychiatry training programs need to incorporate cultural competence training into their curricula. This article documents the unique approach to resident cultural competence training being developed in the Department of Psychiatry at the University of Toronto, which has the largest residency training program in North America and is situated in an ethnically diverse city and country. The authors conducted a systematic review of cultural competence by searching databases including PubMed, PsycINFO, PsycArticles, CINAHL, Social Science Abstracts, and Sociological Abstracts; by searching government and professional association publications; and through on-site visits to local cross-cultural training programs. Based on the results of the review, a resident survey, and a staff retreat, the authors developed a deliberate "integrative" approach with a mindful, balanced emphasis on both generic and specific cultural competencies. Learning objectives were derived from integrating the seven core competencies of a physician as defined by the Canadian Medical Education Directions for Specialists (CanMEDS) roles framework with the tripartite model of attitudes, knowledge, and skills. The learning objectives and teaching program were further integrated across different psychiatric subspecialties and across the successive years of residency. Another unique strategy used to foster curricular and institutional change was the program's emphasis on evaluation, making use of insights from modern educational theories such as formative feedback and blueprinting. Course evaluations of the core curriculum from the first group of residents were positive. The authors propose that these changes to the curriculum may lead to enhanced cultural competence and clinical effectiveness in health care.

  19. Preparation and Evaluation of Taste Masked Famotidine Formulation Using Drug/β-cyclodextrin/Polymer Ternary Complexation Approach


    Patel, Ashok R.; Vavia, Pradeep R.


    The main aim of the present study was to evaluate potential of ternary complexation (comprising of drug, cyclodextrin and polymer) as an approach for taste masking. For this purpose famotidine with property of bitter taste was selected as a model drug. Improvement in taste masking capability of cyclodextrin towards famotidine was evaluated by formulating a ternary complex including hydrophilic polymer hydroxyl propyl methyl cellulose (HPMC 5 cps) as the third component. Phase solubility analy...


    Directory of Open Access Journals (Sweden)

    Victor Imanuel Nalle


    Full Text Available The 21st century is the era of the development of corporate social responsibility (CSR. It is encouraged by the development of the company as a business and societal entities that balances public and private interests. If there is a balance of public and private interests in the company, the application of CSR should be able to accommodate the public interest. But many companies in Indonesia do not involve the community in the formulation of CSR implementation model. This resulted in the implementation of CSR is often not well targeted. In that context, the theory of corporate constitutionalism becomes relevant theory to answer these problems. The theory of corporate constitutionalism put deliberation as one of the principles to achieve the legitimacy of decision-making in the corporation. Through a process of deliberation formulation of CSR model with the community, not just the interests of shareholders that can be accommodated but also the interests of stakeholders. Thus, CSR can actually be instrumental in the global and local challenges.

  1. The relationship between business strategy and organisational culture.



    This study has been undertaken with the specific objective of acquiring an insight into the concept “organisational culture” within a business strategic management context, as well as the role played by the organisation in the formulation and implementation of organisational strategy and culture. In this study an integrated approach is followed in order to describe and analyse the concepts within the context of business strategic management. The study confirms the importance of organisational...

  2. Enabling "new" practices of renewable energy sharing : A cross-cultural approach

    NARCIS (Netherlands)

    Singh, A.; Van Dijk, H.W.; Romero Herrera, N.A.; Keyson, D.V.


    Local generation, distribution and consumption of renewable energy within neighborhood is an emerging application context for the concept of `sharing'. This position paper introduces a cross-cultural approach to enable `new' social practices of renewable energy sharing in neighborhoods. The approach

  3. Fundamental principles of the cultural-activity approach in the psychology of giftedness


    Babaeva, Julia


    This article examines the cultural-activity approach to the study of giftedness, which is based on the ideas of L. S. Vygotsky, A. N. Leontiev, and O. K. Tikhomirov. Three basic principles of this approach are described: the principle of polymorphism, the dynamic principle, and the principle of the holistic analysis of the giftedness phenomenon. The article introduces the results of empirical research (including a 10-year longitudinal study), which verifies the efficacy of the cultural-activi...

  4. Towards the implementation of the Nigerian cultural policy for the ...

    African Journals Online (AJOL)

    Nigeria is among one of the African countries that took a cue from Ghana to formulate its national cultural policy at the insistence of the United Nations Education Scientific and Cultural Organisation (UNESCO). Since 1976 when Nigerian formulated her cultural policy till date (2009), gaping loopholes exist which hinder the ...

  5. Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulations

    Directory of Open Access Journals (Sweden)

    Dezzutti Charlene


    Full Text Available Abstract Background The objective of this study is to identify the critical formulation parameters controlling distribution and function for the rectal administration of microbicides in humans. Four placebo formulations were designed with a wide range of hydrophilic characteristics (aqueous to lipid and rheological properties (Newtonian, shear thinning, thermal sensitive and thixotropic. Aqueous formulations using typical polymers to control viscosity were iso-osmotic and buffered to pH 7. Lipid formulations were developed from lipid solvent/lipid gelling agent binary mixtures. Testing included pharmaceutical function and stability as well as in vitro and in vivo toxicity. Results The aqueous fluid placebo, based on poloxamer, was fluid at room temperature, thickened and became shear thinning at 37°C. The aqueous gel placebo used carbopol as the gelling agent, was shear thinning at room temperature and showed a typical decrease in viscosity with an increase in temperature. The lipid fluid placebo, myristyl myristate in isopropyl myristate, was relatively thin and temperature independent. The lipid gel placebo, glyceryl stearate and PEG-75 stearate in caprylic/capric triglycerides, was also shear thinning at both room temperature and 37°C but with significant time dependency or thixotropy. All formulations showed no rectal irritation in rabbits and were non-toxic using an ex vivo rectal explant model. Conclusions Four placebo formulations ranging from fluid to gel in aqueous and lipid formats with a range of rheological properties were developed, tested, scaled-up, manufactured under cGMP conditions and enrolled in a formal stability program. Clinical testing of these formulations as placebos will serve as the basis for further microbicide formulation development with drug-containing products.

  6. Formulation development of the biocontrol agent Bacillus subtilis strain CPA-8 by spray-drying. (United States)

    Yánez-Mendizábal, V; Viñas, I; Usall, J; Torres, R; Solsona, C; Abadias, M; Teixidó, N


    To prepare commercially acceptable formulations of Bacillus subtilis CPA-8 by spray-drying with long storage life and retained efficacy to control peach and nectarine brown rot caused by Monilinia spp. CPA-8 24-h- and 72-h-old cultures were spray dried using 10% skimmed milk, 10% skimmed milk plus 10% MgSO(4) , 10% MgSO(4) and 20% MgSO(4) as carriers/protectants. All carriers/protectants gave good percentages of powder recovery (28-38%) and moisture content (7-13%). CPA-8 survival varied considerably among spray-dried 24-h- and 72-h-old cultures. Seventy-two hours culture spray dried formulations showed the highest survival (28-32%) with final concentration products of 1·6-3·3 × 10(9) CFU g(-1) , while viability of 24-h-old formulations was lower than 1%. Spray-dried 72-h-old formulations were selected to subsequent evaluation. Rehydration of cells with water provided a good recovery of CPA-8 dried cells, similar to other complex rehydration media tested. Spray-dried formulations stored at 4 ± 1 and 20 ± 1°C showed good shelf life during 6 months, and viability was maintained or slightly decreased by 0·2-0·3-log. CPA-8 formulations after 4- and 6 months storage were effective in controlling brown rot caused by Monilinia spp. on nectarines and peaches resulting in a 90-100% reduction in disease incidence. Stable and effective formulations of biocontrol agent B. subtilis CPA-8 could be obtained by spray-drying. New shelf-stable and effective formulations of a biocontrol agent have been obtained by spray-drying to control brown rot on peach. © 2012 The Authors. Journal of Applied Microbiology © 2012 The Society for Applied Microbiology.

  7. Cultural Approach to HIV/AIDS Harm Reduction in Muslim Countries

    Directory of Open Access Journals (Sweden)

    Hasnain Memoona


    Full Text Available Abstract Muslim countries, previously considered protected from HIV/AIDS due to religious and cultural norms, are facing a rapidly rising threat. Despite the evidence of an advancing epidemic, the usual response from the policy makers in Muslim countries, for protection against HIV infection, is a major focus on propagating abstention from illicit drug and sexual practices. Sexuality, considered a private matter, is a taboo topic for discussion. Harm reduction, a pragmatic approach for HIV prevention, is underutilized. The social stigma attached to HIV/AIDS, that exists in all societies is much more pronounced in Muslim cultures. This stigma prevents those at risk from coming forward for appropriate counseling, testing, and treatment, as it involves disclosure of risky practices. The purpose of this paper is to define the extent of the HIV/AIDS problem in Muslim countries, outline the major challenges to HIV/AIDS prevention and treatment, and discuss the concept of harm reduction, with a cultural approach, as a strategy to prevent further spread of the disease. Recommendations include integrating HIV prevention and treatment strategies within existing social, cultural and religious frameworks, working with religious leaders as key collaborators, and provision of appropriate healthcare resources and infrastructure for successful HIV prevention and treatment programs in Muslim countries.

  8. Finite element analysis of structures through unified formulation

    CERN Document Server

    Carrera, Erasmo; Petrolo, Marco; Zappino, Enrico


    The finite element method (FEM) is a computational tool widely used to design and analyse  complex structures. Currently, there are a number of different approaches to analysis using the FEM that vary according to the type of structure being analysed: beams and plates may use 1D or 2D approaches, shells and solids 2D or 3D approaches, and methods that work for one structure are typically not optimized to work for another. Finite Element Analysis of Structures Through Unified Formulation deals with the FEM used for the analysis of the mechanics of structures in the case of linear elasticity. The novelty of this book is that the finite elements (FEs) are formulated on the basis of a class of theories of structures known as the Carrera Unified Formulation (CUF). It formulates 1D, 2D and 3D FEs on the basis of the same ''fundamental nucleus'' that comes from geometrical relations and Hooke''s law, and presents both 1D and 2D refined FEs that only have displacement variables as in 3D elements. It also covers 1D...

  9. Assessment of safety culture: Changing regulatory approach in Hungary

    International Nuclear Information System (INIS)

    Ronaky, Jozsef; Toth, Andras


    Hungarian Atomic Energy Authority (HAEA) is changing its inspection practice and assessment methods of safety performance and safety culture in operating nuclear facilities. The new approach emphasises integrated team inspection of safety cornerstones and systematic assessment of safety performance of operators. (author)

  10. Nuclear safety and security culture - an integrated approach to regulatory oversight

    International Nuclear Information System (INIS)

    Tronea, M.; Ciurea Ercau, C.


    The paper presents the development and implementation of regulatory guidelines for the oversight of safety and security culture within licensees organizations. CNCAN (the National Commission for Nuclear Activities of Romania) has used the International Atomic Energy Agency (IAEA) attributes for a strong safety culture as the basis for its regulatory guidelines providing support to the reviewers and inspectors for recognizing and gathering information relevant to safety culture. These guidelines are in process of being extended to address also security culture, based on the IAEA Nuclear Security Series No. 7 document Nuclear Security Culture: Implementing Guide. Recognizing that safety and security cultures coexist and need to reinforce each other because they share the common objective of limiting risk and that similar regulatory review and inspection processes are in place for nuclear security oversight, an integrated approach is considered justified, moreover since the common elements of these cultures outweigh the differences. (authors)

  11. Community Collectivism: A social dynamic approach to conceptualizing culture. (United States)

    Akkuş, Birol; Postmes, Tom; Stroebe, Katherine


    Culture shapes individuals, but the measurement of cultural differences has proven a challenge. Traditional measures of cultural values focus on individual perceptions. We suggest that values are established and maintained within social communities of proximate others, such as the family and its social environment. Within such communities, values serve to maintain collective harmony whilst preserving individual agency. From a social-dynamic analysis of communities, we infer that community values of loyalty regulate individual commitment, values of honor regulate norm compliance, and values of group hierarchy maintain a division of labor. In addition, communities may regulate the ways in which individuals have independent agency. A new scale to measure these values was validated in four studies (N = 398, 112, 465 and 111) among Dutch (religious and non-religious), Turkish-Dutch, Surinamese and Turkish groups. Values and practices were measured at the level of the individual ('What do you value?') and at the level of the perceived community ('What does your community value?'). Results show that, unlike individual-level measures of individualism/collectivism, this scale has excellent reliability, differentiates between cultural groups, and has predictive validity for future (voting) behavior. This approach provides a new way of conceptualizing culture, a new measure of collectivism and new insights into the role of proximate others in shaping culture.

  12. Positive Emotion Regulation and Psychopathology: A Transdiagnostic Cultural Neuroscience Approach (United States)

    Hechtman, Lisa A.; Raila, Hannah; Chiao, Joan Y.; Gruber, June


    There is burgeoning interest in the study of positive emotion regulation and psychopathology. Given the significant public health costs and the tremendous variance in national prevalence rates associated with many disorders of positive emotion, it is critical to reach an understanding of how cultural factors, along with biological factors, mutually influence positive emotion regulation. Progress in this domain has been relatively unexplored, however, underscoring the need for an integrative review and empirical roadmap for investigating the cultural neuroscientific contributions to positive emotion disturbance for both affective and clinical science domains. The present paper thus provides a multidisciplinary, cultural neuroscience approach to better understand positive emotion regulation and psychopathology. We conclude with a future roadmap for researchers aimed at harnessing positive emotion and alleviating the burden of mental illness cross-culturally. PMID:24812583

  13. Formulation of Fast-Dissolving Tablets of Promethazine Theoclate ...

    African Journals Online (AJOL)

    Purpose: To optimize and formulate promethazine theoclate fast-dissolving tablets that offer a suitable approach to the treatment of nausea and vomiting. Method: The solubility of promethazine theoclate was increased by formulating it as a fast-dissolving tablet containing β-cyclodextrin, crospovidone, and camphor, using ...

  14. Triphala, a formulation of traditional Ayurvedic medicine, shows

    Indian Academy of Sciences (India)

    Triphala, a formulation of traditional Ayurvedic medicine, shows protective effect against X-radiation in HeLa cells. YUKI TAKAUJI KENSUKE ... with the cellscultured in vitro. The simple bioassay system with human cultured cells would facilitate the understanding of themolecular basis for the beneficial effects of Triphala.

  15. Experimental validation of flexible multibody dynamics beam formulations

    Energy Technology Data Exchange (ETDEWEB)

    Bauchau, Olivier A., E-mail:; Han, Shilei [University of Michigan-Shanghai Jiao Tong University Joint Institute (China); Mikkola, Aki; Matikainen, Marko K. [Lappeenranta University of Technology, Department of Mechanical Engineering (Finland); Gruber, Peter [Austrian Center of Competence in Mechatronics GmbH (Austria)


    In this paper, the accuracies of the geometrically exact beam and absolute nodal coordinate formulations are studied by comparing their predictions against an experimental data set referred to as the “Princeton beam experiment.” The experiment deals with a cantilevered beam experiencing coupled flap, lag, and twist deformations. In the absolute nodal coordinate formulation, two different beam elements are used. The first is based on a shear deformable approach in which the element kinematics is described using two nodes. The second is based on a recently proposed approach featuring three nodes. The numerical results for the geometrically exact beam formulation and the recently proposed three-node absolute nodal coordinate formulation agree well with the experimental data. The two-node beam element predictions are similar to those of linear beam theory. This study suggests that a careful and thorough evaluation of beam elements must be carried out to assess their ability to deal with the three-dimensional deformations typically found in flexible multibody systems.

  16. State-Space Formulation for Circuit Analysis (United States)

    Martinez-Marin, T.


    This paper presents a new state-space approach for temporal analysis of electrical circuits. The method systematically obtains the state-space formulation of nondegenerate linear networks without using concepts of topology. It employs nodal/mesh systematic analysis to reduce the number of undesired variables. This approach helps students to…

  17. Pricing index-based catastrophe bonds: Part 1: Formulation and discretization issues using a numerical PDE approach (United States)

    Unger, André J. A.


    This work is the first installment in a two-part series, and focuses on the development of a numerical PDE approach to price components of a Bermudan-style callable catastrophe (CAT) bond. The bond is based on two underlying stochastic variables; the PCS index which posts quarterly estimates of industry-wide hurricane losses as well as a single-factor CIR interest rate model for the three-month LIBOR. The aggregate PCS index is analogous to losses claimed under traditional reinsurance in that it is used to specify a reinsurance layer. The proposed CAT bond model contains a Bermudan-style call feature designed to allow the reinsurer to minimize their interest rate risk exposure on making substantial fixed coupon payments using capital from the reinsurance premium. Numerical PDE methods are the fundamental strategy for pricing early-exercise constraints, such as the Bermudan-style call feature, into contingent claim models. Therefore, the objective and unique contribution of this first installment in the two-part series is to develop a formulation and discretization strategy for the proposed CAT bond model utilizing a numerical PDE approach. Object-oriented code design is fundamental to the numerical methods used to aggregate the PCS index, and implement the call feature. Therefore, object-oriented design issues that relate specifically to the development of a numerical PDE approach for the component of the proposed CAT bond model that depends on the PCS index and LIBOR are described here. Formulation, numerical methods and code design issues that relate to aggregating the PCS index and introducing the call option are the subject of the companion paper.

  18. Literature and Lives: A Response-Based, Cultural Studies Approach to Teaching English. (United States)

    Carey-Webb, Allen

    Telling stories from secondary and college English classrooms, this book explores the new possibilities for teaching and learning generated by bringing together reader-response and cultural-studies approaches. The book connects William Shakespeare, Charles Dickens, Mark Twain, and other canonical figures to multicultural writers, popular culture,…

  19. Laboratory Approach to the Diagnosis of Culture-Negative Infective Endocarditis. (United States)

    Subedi, S; Jennings, Z; Chen, S C-A


    Blood-culture negative endocarditis (BCNE) accounts for up to 35% of all cases of infective endocarditis (IE) and is a serious life-threatening condition with considerable morbidity and mortality. Rapid detection and identification of the causative pathogen is essential for timely, directed therapy. Blood-culture negative endocarditis presents a diagnostic and therapeutic challenge. Causes of BCNE are varied including: treatment with antibiotic agents prior to blood culture collection; sub-optimal specimen collection; and/or infection due to fastidious (eg. nutritionally variant streptococci), intracellular (eg. Coxiella burnetii, Bartonella species) or non-culturable or difficult to culture organisms (eg. Mycobacteria, Tropheryma whipplei and fungi); as well as non-infective aetiologies. Here, we review aetiological and diagnostic approaches to BCNE including newer molecular based techniques, with a brief summary of imaging investigation and treatment principles. Copyright © 2017 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

  20. Individualist-Collectivist Culture and Trust Radius : A Multilevel Approach

    NARCIS (Netherlands)

    van Hoorn, André

    We apply a multilevel approach to examine empirically the nexus between individualist and collectivist culture on the one hand and people’s radius of trust on the other. People’s trust level (i.e., the intensity with which people trust other people) has been extensively studied. Increasingly,

  1. A cultural landscape approach to community-based conservation in Solomon Islands

    Directory of Open Access Journals (Sweden)

    Richard K. Walter


    Full Text Available International environmental organizations have an increasing commitment to the development of conservation programs in high-diversity regions where indigenous communities maintain customary rights to their lands and seas. A major challenge that these programs face is the alignment of international conservation values with those of the indigenous communities whose cooperation and support are vital. International environmental organizations are focused on biodiversity conservation, but local communities often have a different range of concerns and interests, only some of which relate to biodiversity. One solution to this problem involves adoption of a cultural landscape approach as the ethical and organizational foundation of the conservation program. In our conservation work in coastal Melanesia, we have developed a cultural landscape approach that involves the construction of a conceptual model of environment that reflects the indigenous perceptions of landscape. This model incorporates cultural, ideational, and spiritual values alongside other ecosystem services and underpins the conservation activities, priorities, and organizational structure of our programs. This cultural landscape model was a reaction to a survey of environmental values conducted by our team in which Solomon Islanders reported far greater interest in conserving cultural heritage sites than any other ecosystem resources. This caused a radical rethinking of community-based conservation programs. The methodologies we adopted are derived from the fields of archaeology and historical anthropology, in which there is an established practice of working through research problems within the framework of indigenous concepts of, and relationship to, landscape. In our work in Isabel Province, Solomon Islands, coastal communities have enthusiastically adopted conservation programs that are based on cultural landscape models that recognize indigenous values. A particularly useful tool is

  2. Screening vaccine formulations for biological activity using fresh human whole blood. (United States)

    Brookes, Roger H; Hakimi, Jalil; Ha, Yukyung; Aboutorabian, Sepideh; Ausar, Salvador F; Hasija, Manvi; Smith, Steven G; Todryk, Stephen M; Dockrell, Hazel M; Rahman, Nausheen


    Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as monoclonal antibodies, a lack of immune response to the formulation is desired. During early formulation development, various biochemical and biophysical characteristics can be monitored in a high-throughput screening (HTS) format. However, it remains impractical and arguably unethical to screen samples in this way for immunological functionality in animal models. Furthermore, data for immunological functionality lag formulation design by months, making it cumbersome to relate back to formulations in real-time. It is also likely that animal testing may not accurately reflect the response in humans. For a more effective formulation screen, a human whole blood (hWB) approach can be used to assess immunological functionality. The functional activity relates directly to the human immune response to a complete formulation (adjuvant/antigen) and includes adjuvant response, antigen response, adjuvant-modulated antigen response, stability, and potentially safety. The following commentary discusses the hWB approach as a valuable new tool to de-risk manufacture, formulation design, and clinical progression.

  3. An herbal formulation for hemorrhoids treatment

    Directory of Open Access Journals (Sweden)

    S. Dehdari


    Full Text Available Background and objectives: Hemorrhoids is the most painful rectal disease. Straining and pregnancy seem playing chief roles in the development of hemorrhoids. Symptoms of hemorrhoids may include bleeding, inflammation and pain. Despite current medical efforts, many discomforts of hemorrhoids have not been handled. The aim of the present study was to formulate and evaluate Itrifal-e muqil (IM tablet to achieve desired pharmaceutical properties. Method: Quality control tests of Allium ampeloperasum L, Commiphora mukul (Hook. ex Stocks Engl., Phyllanthus emblica L., Terminalia chebula Retz. and Terminalia bellerica Retz. were performed. Afterwards, different formulations were prepared and their physical properties were evaluated. Subsequently, the formulation was coated and its physicochemical characteristics were assessed. Result: All of the herbs demonstrated good results in quality control tests according to United State Pharmacopeia (USP. Formulation-1 that was completely prepared based on explained manufacturing process of IM in traditional medicine manuscripts did not show suitable pharmaceutical properties. Among different formulations, Formulation-3 that consisted of A. ampeloperasum, C. mukul, P. emblica, T. chebula and T. bellerica, displayed best outcomes through different tests. Conclusion: Modern pharmaceutical approaches can excellently be adapted for IM preparations.

  4. Autonomy and relatedness in psychopathology and treatment: a cross-cultural formulation. (United States)

    Sato, T


    A cross-cultural view of psychopathology is proposed, contending that there are two basic systems of self-organization. These two systems of self-organization, labeled autonomy and relatedness, are essential to a person's well-being regardless of the culture or society to which the person belongs. The degree of autonomy and relatedness required to maintain mental health in a specific society is affected by cultural mores. People in collectivistic (primarily non-Western) cultures require high levels of relatedness and moderate levels of autonomy to maintain mental health. People in individualistic (primarily Western) cultures require high levels of autonomy and moderate levels of relatedness to maintain mental health. This view, based on a review of past work in various areas of psychology, is discussed in the context of various forms of psychotherapy existing in individualistic and collectivistic cultures.

  5. Application of quality by design approach to optimize process and formulation parameters of rizatriptan loaded chitosan nanoparticles

    Directory of Open Access Journals (Sweden)

    Ajinath Eknath Shirsat


    Full Text Available The purpose of present study was to optimize rizatriptan (RZT chitosan (CS nanoparticles using ionic gelation method by application of quality by design (QbD approach. Based on risk assessment, effect of three variables, that is CS %, tripolyphosphate % and stirring speed were studied on critical quality attributes (CQAs; particle size and entrapment efficiency. Central composite design (CCD was implemented for design of experimentation with 20 runs. RZT CS nanoparticles were characterized for particle size, polydispersity index, entrapment efficiency, in-vitro release study, differential scanning calorimetric, X-ray diffraction, scanning electron microscopy (SEM. Based on QbD approach, design space (DS was optimized with a combination of selected variables with entrapment efficiency > 50% w/w and a particle size between 400 and 600 nm. Validation of model was performed with 3 representative formulations from DS for which standard error of − 0.70-3.29 was observed between experimental and predicted values. In-vitro drug release followed initial burst release 20.26 ± 2.34% in 3-4 h with sustained drug release of 98.43 ± 2.45% in 60 h. Lower magnitude of standard error for CQAs confirms the validation of selected CCD model for optimization of RZT CS nanoparticles. In-vitro drug release followed dual mechanism via, diffusion and polymer erosion. RZT CS nanoparticles were prepared successfully using QbD approach with the understanding of the high risk process and formulation parameters involved and optimized DS with a multifactorial combination of critical parameters to obtain predetermined RZT loaded CS nanoparticle specifications.

  6. Mixture experiment methods in the development and optimization of microemulsion formulations. (United States)

    Furlanetto, S; Cirri, M; Piepel, G; Mennini, N; Mura, P


    Microemulsion formulations represent an interesting delivery vehicle for lipophilic drugs, allowing for improving their solubility and dissolution properties. This work developed effective microemulsion formulations using glyburide (a very poorly-water-soluble hypoglycaemic agent) as a model drug. First, the area of stable microemulsion (ME) formations was identified using a new approach based on mixture experiment methods. A 13-run mixture design was carried out in an experimental region defined by constraints on three components: aqueous, oil and surfactant/cosurfactant. The transmittance percentage (at 550 nm) of ME formulations (indicative of their transparency and thus of their stability) was chosen as the response variable. The results obtained using the mixture experiment approach corresponded well with those obtained using the traditional approach based on pseudo-ternary phase diagrams. However, the mixture experiment approach required far less experimental effort than the traditional approach. A subsequent 13-run mixture experiment, in the region of stable MEs, was then performed to identify the optimal formulation (i.e., having the best glyburide dissolution properties). Percent drug dissolved and dissolution efficiency were selected as the responses to be maximized. The ME formulation optimized via the mixture experiment approach consisted of 78% surfactant/cosurfacant (a mixture of Tween 20 and Transcutol, 1:1, v/v), 5% oil (Labrafac Hydro) and 17% aqueous phase (water). The stable region of MEs was identified using mixture experiment methods for the first time. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Enhanced liposomal vaccine formulation and performance: simple physicochemical and immunological approaches. (United States)

    de Almeida Silva, Vanessa; Sayoko Takata, Célia; Sant'Anna, Osvaldo A; Carlos Lopes, Antônio; Soares de Araujo, Pedro; Helena Bueno da Costa, Maria


    The Dtxd (Diphtheria toxoid) was the first antigen encapsulated within liposomes, their adjuvant properties were discovered (their capacity to enhance the vaccine immunogenicity). The point here is not to propose a new method to prepare this lipossomal vaccine. The central idea is to give new dresses for old vaccines by using classical and well-established liposome preparation method changing only the encapsulation pH and the immunization protocol. The most appropriate method of Dtxd encapsulation within liposome was based on lipid film hydration in 100 mM citrate buffer, pH 4.0. This was accompanied by changes on protein hydrophobicity, observed by CD and fluorescence spectroscopies. Whenever the Dtxd exposed its hydrophobic residues at pH 4.0, it interacted better with the lipossomal (observed by electrophoretic mobility) film than when its hydrophobic residues were buried (pH 9.0). The Dtxd partition coefficient in Triton-X114 and the acrylamide fluorescence quenching were also pH dependent. Both were bigger at pH 4.0 than at pH 9.0. The relationship protein structure and lipid interaction was pH dependent and now it can be easily maximized to enhance encapsulation of antigens in vaccine development. Mice were primed with formulations containing 5 mug of Dtxd within liposomes prepared in pH 4.0 or 7.0 or 9.0. The boosters were done 38 or 138 days after the first immunization. The IgM produced by immediate response of all lipossomal formulations were higher than the control (free protein). The response patterns and the immune maturity were measured by IgG1 and IgG2a titrations. The IgG1 titers produced by both formulations at pH 4.0 and 7.0 were at least 22 higher than those produced by mice injected lipossomal formulation at pH 9.0. When the boosters were done, 138 days after priming the mice produced a IgG2a titer of 29 and the group that received the booster 30 days after priming produced a titer of 25. The strongest antibody production was the neutralizing

  8. Community Collectivism: A social dynamic approach to conceptualizing culture (United States)

    Postmes, Tom; Stroebe, Katherine


    Culture shapes individuals, but the measurement of cultural differences has proven a challenge. Traditional measures of cultural values focus on individual perceptions. We suggest that values are established and maintained within social communities of proximate others, such as the family and its social environment. Within such communities, values serve to maintain collective harmony whilst preserving individual agency. From a social-dynamic analysis of communities, we infer that community values of loyalty regulate individual commitment, values of honor regulate norm compliance, and values of group hierarchy maintain a division of labor. In addition, communities may regulate the ways in which individuals have independent agency. A new scale to measure these values was validated in four studies (N = 398, 112, 465 and 111) among Dutch (religious and non-religious), Turkish-Dutch, Surinamese and Turkish groups. Values and practices were measured at the level of the individual (‘What do you value?’) and at the level of the perceived community (‘What does your community value?’). Results show that, unlike individual-level measures of individualism/collectivism, this scale has excellent reliability, differentiates between cultural groups, and has predictive validity for future (voting) behavior. This approach provides a new way of conceptualizing culture, a new measure of collectivism and new insights into the role of proximate others in shaping culture. PMID:28957447

  9. Community Collectivism: A social dynamic approach to conceptualizing culture.

    Directory of Open Access Journals (Sweden)

    Birol Akkuş

    Full Text Available Culture shapes individuals, but the measurement of cultural differences has proven a challenge. Traditional measures of cultural values focus on individual perceptions. We suggest that values are established and maintained within social communities of proximate others, such as the family and its social environment. Within such communities, values serve to maintain collective harmony whilst preserving individual agency. From a social-dynamic analysis of communities, we infer that community values of loyalty regulate individual commitment, values of honor regulate norm compliance, and values of group hierarchy maintain a division of labor. In addition, communities may regulate the ways in which individuals have independent agency. A new scale to measure these values was validated in four studies (N = 398, 112, 465 and 111 among Dutch (religious and non-religious, Turkish-Dutch, Surinamese and Turkish groups. Values and practices were measured at the level of the individual ('What do you value?' and at the level of the perceived community ('What does your community value?'. Results show that, unlike individual-level measures of individualism/collectivism, this scale has excellent reliability, differentiates between cultural groups, and has predictive validity for future (voting behavior. This approach provides a new way of conceptualizing culture, a new measure of collectivism and new insights into the role of proximate others in shaping culture.

  10. Madurese cultural communication approach (United States)

    Dharmawan, A.; Aji, G. G.; Mutiah


    Madura is a tribe with a cultural entity influenced by the ecological aspect and Madurese people. Assessing Madurese culture cannot be separated from the relation of society and ecological aspects that form the characteristics of Madura culture. Stereotypes of Madurese include a stubborn attitude, and carok or killing as a problem solving. On the other hand, Madurese are known to be inclusive, religious, and hardworking. The basic assumption is that the ecological conditions in Madura also shape the social and cultural life of the Madurese. Therefore, judging the Madurese cannot just be seen from a single event only. Moreover, the assessment only focuses on Madurese violence and disregards their structure and social aspects. Assessing Madura culture as a whole can explain the characteristics of Madurese community. According Hofstede culture is a characteristic mindset and perspective of individuals or groups of society in addressing a distinguished life. These differences distinguish individuals from others, or one country to the other. According to Hofstede to be able to assess the culture can be explained by four dimensions namely, individualism-collectivism, uncertainty avoidance, masculinity-femininity and power distance. The method used in this research is a case study. The Result is Madurese classified collectivism can be viewed from the pattern of settlements called kampong meji. Madurese can be classified into low and high uncertainty avoidance. the power distance for the Madurese is classified as unequally or there is a distance of power based on social groups. The element of masculinity of the Madurese is shown to be found when the earnestness of work.


    Directory of Open Access Journals (Sweden)

    N. N. Ulasiuk


    Full Text Available The executed researches of studying historical manors of Belarus, the analysis of domestic and foreign experience of restoration and modem use of manors have allowed to formulate purposes, principles, conceptual approaches and methods of restoration and adaptation of historical manors for cultural and tourist use.

  12. Development and optimization of a new processing approach for manufacturing topical liposomes-in-hydrogel drug formulations by dual asymmetric centrifugation. (United States)

    Ingebrigtsen, Sveinung G; Škalko-Basnet, Nataša; Holsæter, Ann Mari


    The objective of the present study was to utilize dual asymmetric centrifugation (DAC) as a novel processing approach for the production of liposomes-in-hydrogel formulations. Lipid films of phosphatidylcholine, with and without chloramphenicol (CAM), were hydrated and homogenized by DAC to produce liposomes in the form of vesicular phospholipid gels with a diameter in the size range of 200-300 nm suitable for drug delivery to the skin. Different homogenization processing parameters were investigated along with the effect of adding propylene glycol (PG) to the formulations prior to homogenization. The produced liposomes were incorporated into a hydrogel made of 2.5% (v/v) soluble β-1,3/1,6-glucan (SBG) and mixed by DAC to achieve a homogenous liposomes-in-hydrogel-formulation suitable for topical application. CAM-containing liposomes with a vesicle diameter of 282 ± 30 nm and polydispersity index (PI) of 0.13 ± 0.02 were successfully produced by DAC after 50 min centrifugation at 3500 rpm, and homogenously (< 4% content variation) incorporated into the SBG hydrogel. Addition of PG decreased the necessary centrifugation time to 2 min and 55 s, producing liposomes of 230 ± 51 nm and PI of 0.25 ± 0.04. All formulations had an entrapment efficiency of approximately 50%. We managed to develop a relatively fast and reproducible new method for the production of liposomes-in-hydrogel formulations by DAC.


    Institute of Scientific and Technical Information of China (English)


    Dongting Lake is internationally an important wetland. We studied and summarized the conception, function, classification and current situation of the wetland-landscape culture in this region. The results showed that the culture of Dongting Lake wetland was rich in diversity, which are the Rice Cultivation Culture, high-balustrade dwelling,Nuo Culture, Ship Culture, Dragon Boat Culture, Chu Culture, Ancient Architecture Landscape, Wetland Foodstuff andCuisine Culture, Civil Art, Historic Heritage and Cultural Relics, Revolutionary Sites and Ruins, and Production andLiving Culture, etc. We also evaluated the eeo-tourism value of wetland landscape culture, and analyzed its features andorientation. The results revealed that the south Dongting Lake wetland plays a key role on the Changjiang(Yangtze) Riverreaches civilization and Chinese civilization, even has great influence on the global civilization. We summarized that thesoul of the south Dongting Lake Culture was Wetland Culture, Water Culture, Rice Cultivation and Chu Culture. Thethoughts, principles and approaches of sustainable exploitation and utilization of the wetland landscape culture were formulated and suggested.

  14. Enzymatic formulation capable of degrading scrapie prion under mild digestion conditions.

    Directory of Open Access Journals (Sweden)

    Emeka A Okoroma

    Full Text Available The prion agent is notoriously resistant to common proteases and conventional sterilisation procedures. The current methods known to destroy prion infectivity such as incineration, alkaline and thermal hydrolysis are harsh, destructive, environmentally polluting and potentially hazardous, thus limit their applications for decontamination of delicate medical and laboratory devices, remediation of prion contaminated environment and for processing animal by-products including specified risk materials and carcases. Therefore, an environmentally friendly, non-destructive enzymatic degradation approach is highly desirable. A feather-degrading Bacillus licheniformis N22 keratinase has been isolated which degraded scrapie prion to undetectable level of PrP(Sc signals as determined by Western Blot analysis. Prion infectivity was verified by ex vivo cell-based assay. An enzymatic formulation combining N22 keratinase and biosurfactant derived from Pseudomonas aeruginosa degraded PrP(Sc at 65 °C in 10 min to undetectable level -. A time-course degradation analysis carried out at 50 °C over 2 h revealed the progressive attenuation of PrP(Sc intensity. Test of residual infectivity by standard cell culture assay confirmed that the enzymatic formulation reduced PrP(Sc infectivity to undetectable levels as compared to cells challenged with untreated standard scrapie sheep prion (SSBP/1 (p-value = 0.008 at 95% confidence interval. This novel enzymatic formulation has significant potential application for prion decontamination in various environmentally friendly systems under mild treatment conditions.

  15. Four Approaches to Cultural Diversity: Implications for Teaching at Institutions of Higher Education. (United States)

    Ofori-Dankwa, Joseph; Lane, Robert W.


    Identifies four approaches to cultural diversity that professors at institutions of higher education may take. These are neutrality, similarity, diversity, and diversimilarity. Identifies the strengths and weaknesses of each of these approaches, and argues for the diversimilarity approach, using the teaching of the death penalty (and examination…

  16. A Systematic Approach to Cultural Explanations of War: Tracing Causal Processes in Two West African Insurgencies

    NARCIS (Netherlands)

    Richards, P.


    Many accounts of cultural factors in armed conflicts are dependent on circumstantial details. Alternative quantitative approaches suffer from confusion of correlation and cause. This paper describes and exemplifies a third approach to the analysis of cultural factors in war—causal process tracing.

  17. Controversies in oncologist-patient communication: a nuanced approach to autonomy, culture, and paternalism. (United States)

    Cherny, Nathan I


    Difficult dialogues with patients facing life-changing decisions are an intrinsic part of oncologic practice and a major source of stress. Having a sophisticated approach to the concepts of autonomy, paternalism, and culture can help in addressing difficult dilemmas that arise around the issues of disclosure and decision making. This article addresses some of the most common major challenges in oncologist-patient communication with a nuanced approach to the concepts of autonomy, paternalism, and culture. It introduces the new concept of"voluntary diminished autonomy" and describes the implications this concept has for the consent process. It also attempts to bring clarity to common problems and misconceptions relating to culture, paternalism, and therapeutic privilege as these pertain to the communication practices of oncologists.

  18. An Extrusion Spheronization Approach to Enable a High Drug Load Formulation of a Poorly Soluble Drug with a Low Melting Surfactant. (United States)

    Tatavarti, Aditya; Kesisoglou, Filippos


    Vitamin E tocopherol polyethylene glycol succinate (TPGS) is a non-ionic surface active agent, known to enhance the bioavailability of lipophilic compounds via wettability, solubility, and in some cases permeability enhancement. MK-0536 is an anti-retroviral drug with poor wettability and solubility and a high dose. Based on pharmacokinetic studies in dogs and humans, use of vitamin E TPGS in oral solid formulations of MK-0536 provides desired PK characteristics. The use of vitamin E TPGS, however, in solid dosage forms is limited because of the processing challenges resulting from its waxy nature and low melting temperature (∼37°C). The current study, for the first time, demonstrates the use of an alternative low pressure extrusion and spheronization approach to enable high loadings of the poorly soluble, poorly compactable drug and relatively high levels of vitamin E TPGS. This approach not only aided in mitigating processing challenges arising from most high energy process steps such as milling, compression, and coating, but also enabled a higher drug load formulation that provided superior bioperformance relative to a conventional high shear wet granulated formulation. An encapsulated dosage form consisting of pellets prepared by extrusion spheronization with 75% (w/w) MK-0536 and 10% (w/w) vitamin E TPGS was developed. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

  19. High-Order Entropy Stable Formulations for Computational Fluid Dynamics (United States)

    Carpenter, Mark H.; Fisher, Travis C.


    A systematic approach is presented for developing entropy stable (SS) formulations of any order for the Navier-Stokes equations. These SS formulations discretely conserve mass, momentum, energy and satisfy a mathematical entropy inequality. They are valid for smooth as well as discontinuous flows provided sufficient dissipation is added at shocks and discontinuities. Entropy stable formulations exist for all diagonal norm, summation-by-parts (SBP) operators, including all centered finite-difference operators, Legendre collocation finite-element operators, and certain finite-volume operators. Examples are presented using various entropy stable formulations that demonstrate the current state-of-the-art of these schemes.

  20. Economic culture of the Tuvans within the scope of the sociocultural approach

    Directory of Open Access Journals (Sweden)

    Yuri V. Popkov


    Full Text Available In this article, the authors argue that for the periods of social turmoil, understanding culture as a set of norms controlling social behavior is limited and insufficient. A more adequate approach would involve interpreting culture as a specific historical version of the society’s existence in its qualitative form. This hearkens back to the sociocultural approach which postulates the culture as an ensemble, and the sociocultural construed as the social in the cultural variety. In this context, economic culture might be seen as a set of qualitative features of a specific economic entity shaped by the local conditions of development. With all its peculiarities, an economic culture appears an element of this sociocultural diversity. Studying the economic culture of Tuvans through the lens of the sociocultural approach and the notion of this diversity allows us to outline several important aspects of this issue, rarely addressed by the existing academic discourse. A focus should be made, for instance, not only on the dominant nomadic culture, but also on subdominant economic cultures which helped shape a number of skills and techniques. While nomadism helped develop unhurried and contemplative attitude to life, hunting demanded dynamic change, and agriculture and crafts called for diligence and meticulousness. A brief glance at the economic history of Tuvans allowed the authors to conclude that economic diversity both provides stability to the economic culture of Tuvan society and expresses its variegation, its capacity to develop through numerous modifications. This polymorphism acts as an important resource which helps launch the alternate routes of ethnic development. These routes rarely appear self-evident under the dominant type of economic culture which had been shaping the traditional life of Tuvan society. Tapping into this alternative potential can prove an important reserve for future development. An overview of ethnographic data helps

  1. Increasing cell culture population doublings for long-term growth of finite life span human cell cultures (United States)

    Stampfer, Martha R; Garbe, James C


    Cell culture media formulations for culturing human epithelial cells are herein described. Also described are methods of increasing population doublings in a cell culture of finite life span human epithelial cells and prolonging the life span of human cell cultures. Using the cell culture media disclosed alone and in combination with addition to the cell culture of a compound associated with anti-stress activity achieves extended growth of pre-stasis cells and increased population doublings and life span in human epithelial cell cultures.

  2. A Cultural Approach to Learning

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard


    The this article learning is discussed in relation to different understanding of culture. In particular the dialectics of 'Enlightenment' inthe Western culture are reflected , as well aslow- and high-context communication and learningin different types of culture. Finaaly the Weberian methodology...

  3. A non-linear programming approach to the computer-aided design of regulators using a linear-quadratic formulation (United States)

    Fleming, P.


    A design technique is proposed for linear regulators in which a feedback controller of fixed structure is chosen to minimize an integral quadratic objective function subject to the satisfaction of integral quadratic constraint functions. Application of a non-linear programming algorithm to this mathematically tractable formulation results in an efficient and useful computer-aided design tool. Particular attention is paid to computational efficiency and various recommendations are made. Two design examples illustrate the flexibility of the approach and highlight the special insight afforded to the designer.

  4. New approaches for the asessment and education of children under socio-cultural disadvantages

    Directory of Open Access Journals (Sweden)

    Alegría Majluf


    Full Text Available The present paper describes the traditional psychometric parameters thal don 't fit by workingwith children who suffer socio-cultural deprivation (or who are living under socio-cultural disadvantagesand the new assessment and education strategies for this population. Vygotsky's socio-cultural approach, that emphasizes the Zone of Proximal Development, and the Dynamic Assessment and the Mediated Learning developed by Feucrstein and complemented by Coll relatedwith the Significative Learning are stressed.

  5. Development and evaluation of a teaching and learning approach in cross-cultural care and antidiscrimination in university nursing students. (United States)

    Allen, Jacqui; Brown, Lucinda; Duff, Carmel; Nesbitt, Pat; Hepner, Anne


    Cross-cultural care and antidiscrimination are vital to ethical effective health systems. Nurses require quality educational preparation in cross-cultural care and antidiscrimination. Limited evidence-based research is available to guide teachers. To develop, implement and evaluate an evidence-based teaching and learning approach in cross-cultural care and antidiscrimination for undergraduate nursing students. A quantitative design using pre- and post-survey measures was used to evaluate the teaching and learning approach. The Bachelor of Nursing program in an Australian university. Academics and second year undergraduate nursing students. A literature review and consultation with academics informed the development of the teaching and learning approach. Thirty-three students completed a survey at pre-measures and following participation in the teaching and learning approach at post-measures about their confidence to practice cross-cultural nursing (Transcultural Self-efficacy Tool) and about their discriminatory attitudes (Quick Discrimination Index). The literature review found that educational approaches that solely focus on culture might not be sufficient in addressing discrimination and racism. During consultation, academics emphasised the importance of situating cross-cultural nursing and antidiscrimination as social determinants of health. Therefore, cross-cultural nursing was contextualised within primary health care and emphasised care for culturally diverse communities. Survey findings supported the effectiveness of this strategy in promoting students' confidence regarding knowledge about cross-cultural nursing. There was no reported change in discriminatory attitudes. The teaching and learning approach was modified to include stronger experiential learning and role playing. Nursing education should emphasise cross-cultural nursing and antidiscrimination. The study describes an evaluated teaching and learning approach and demonstrates how evaluation

  6. Efficacies of Gel Formulations Containing Foscarnet, Alone or Combined with Sodium Lauryl Sulfate, against Establishment and Reactivation of Latent Herpes Simplex Virus Type 1 (United States)

    Piret, Jocelyne; Lamontagne, Julie; Désormeaux, André; Bergeron, Michel G.


    The influence of sodium lauryl sulfate (SLS) on the efficacies of gel formulations of foscarnet against herpes simplex virus type 1 (HSV-1) cutaneous lesions and on the establishment and reactivation of latent virus has been evaluated in a murine model of orofacial infection. Topical treatments were given twice daily for 3 days and were initiated at 6, 24, and 48 h after virus inoculation. The gel formulation that contained both 3% foscarnet and 5% SLS and that was administered within 48 h postinfection reduced the rate of development of herpetic skin lesions. This formulation also significantly decreased the viral content in skin tissues and in ipsilateral trigeminal ganglia when it was given within 24 and 6 h postinfection, respectively. A lower level of efficacy was observed for the gel formulation containing 3% foscarnet alone. Of prime interest, the gel formulation containing 5% SLS reduced significantly the mortality rate among mice in a zosteriform model of infection. Both formulations of foscarnet had no effect on the mean titers of reactivated virus in explant cultures of ipsilateral and contralateral trigeminal ganglia from latently infected mice. The use of a gel formulation containing combinations of foscarnet and SLS could represent an attractive approach for the treatment of herpetic mucocutaneous infections. PMID:11257012

  7. Development of Oral Flexible Tablet (OFT) Formulation for Pediatric and Geriatric Patients: a Novel Age-Appropriate Formulation Platform. (United States)

    Chandrasekaran, Prabagaran; Kandasamy, Ruckmani


    Development of palatable formulations for pediatric and geriatric patients involves various challenges. However, an innovative development with beneficial characteristics of marketed formulations in a single formulation platform was attempted. The goal of this research was to develop solid oral flexible tablets (OFTs) as a platform for pediatrics and geriatrics as oral delivery is the most convenient and widely used mode of drug administration. For this purpose, a flexible tablet formulation using cetirizine hydrochloride as model stability labile class 1 and 3 drug as per the Biopharmaceutical Classification System was developed. Betadex, Eudragit E100, and polacrilex resin were evaluated as taste masking agents. Development work focused on excipient selection, formulation processing, characterization methods, stability, and palatability testing. Formulation with a cetirizine-to-polacrilex ratio of 1:2 to 1:3 showed robust physical strength with friability of 0.1% (w/w), rapid in vitro dispersion within 30 s in 2-6 ml of water, and 0.2% of total organic and elemental impurities. Polacrilex resin formulation shows immediate drug release within 30 min in gastric media, better taste masking, and acceptable stability. Hence, it is concluded that ion exchange resins can be appropriately used to develop taste-masked, rapidly dispersible, and stable tablet formulations with tailored drug release suitable for pediatrics and geriatrics. Flexible formulations can be consumed as swallowable, orally disintegrating, chewable, and as dispersible tablets. Flexibility in dose administration would improve compliance in pediatrics and geriatrics. This drug development approach using ion exchange resins can be a platform for formulating solid oral flexible drug products with low to medium doses.

  8. Designing a primary science curriculum in a globalizing world: How do social constructivism and Vietnamese culture meet? (United States)

    Hằng, Ngô Vũ Thu; Meijer, Marijn Roland; Bulte, Astrid M. W.; Pilot, Albert


    The implementation of social constructivist approaches to learning science in primary education in Vietnamese culture as an example of Confucian heritage culture remains challenging and problematic. This theoretical paper focuses on the initial phase of a design-based research approach; that is, the description of the design of a formal, written curriculum for primary science education in which features of social constructivist approaches to learning are synthesized with essential aspects of Vietnamese culture. The written design comprises learning aims, a framework that is the synthesis of learning functions, learning settings and educational expectations for learning phases, and exemplary curriculum units. Learning aims are formulated to comprehensively develop scientific knowledge, skills, and attitudes toward science for primary students. Derived from these learning aims, the designed framework consists of four learning phases respectively labeled as Engagement, Experience, Exchange, and Follow-up. The designed framework refers to knowledge of the "nature of science" education and characteristics of Vietnamese culture as an example of Confucian heritage culture. The curriculum design aims to serve as an educational product that addresses previously analyzed problems of primary science education in the Vietnamese culture in a globalizing world.

  9. Formulation and Evaluation of Organogels Containing Hyaluronan Microparticles for Topical Delivery of Caffeine. (United States)

    Simsolo, Erol Eli; Eroğlu, İpek; Tanrıverdi, Sakine Tuncay; Özer, Özgen


    Cellulite is a dermal disorder including the extracellular matrix, the lymphatic and microcirculatory systems and the adipose tissue. Caffeine is used as the active moiety depending its preventive effect on localization of fat in the cellular structure. Hyaluronic acid (hyaluronan-HA) is a natural constituent of skin that generates formation and poliferation of new cells having a remarkable moisturizing ability. The aim of this study is to formulate HA microparticles loaded with caffeine via spray-drying method. Resulting microparticle formulations (33.97 ± 0.3 μm, span < 2, 88.56 ± 0.42% encapsulation efficiency) were distributed in lecithin organogels to maintain the proper viscosity for topical application. Following the characterization and cell culture studies, in vitro drug release and ex vivo permeation studies were performed. The accumulated amount of caffeine was twice higher than the aqueous solution for the microparticle-loaded organogels at 24 h (8262,673 μg/cm 2 versus 4676,691 μg/cm 2 ). It was related to the sustained behaviour of caffeine release from the microparticles. As a result, lecithin organogel containing HA-encapsulated microparticles could be considered as suitable candidate formulations for efficient topical drug delivery system of caffeine. In addition to that, synergistic effect of this combination appears as a promising approach for long-acting treatment of cellulite.

  10. Cross-Cultural Film Study: Seeing Inside Out (Approaches to Teaching Freedom of Expression). (United States)

    Aufderheide, Patricia


    Explores classroom approaches to multicultural film study which seek to avoid miscommunication between cultures. Suggests that instructors prepare a checklist of factors to help students identify how specific films relay their messages. Argues that film study can broaden students' notions of free expression, and frame it as a cultural challenge.…

  11. Validation of flexible multibody dynamics beam formulations using benchmark problems

    NARCIS (Netherlands)

    Bauchau, O.A.; Wu, Genyong; Betsch, P.; Cardona, A.; Gerstmayr, J.; Jonker, Jan B.; Masarati, P.; Sonneville, V.


    As the need to model flexibility arose in multibody dynamics, the floating frame of reference formulation was developed, but this approach can yield inaccurate results when elastic displacements becomes large. While the use of three-dimensional finite element formulations overcomes this problem, the

  12. Engaged Problem Formulation of IT Management in Danish Municipalities

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby


    Municipalities’ effectiveness in managing information technology (IT) is increasingly important in adhering to their responsibilities for providing services to citizens. While the municipalities’ difficulty in managing IT has been well documented, it is more elusive what specific problems are most...... relevant in contemporary municipal IT management practice. On this basis, we present an engaged scholarship approach to formulate IT management problems together with municipalities - not for municipalities. We have come to understand such engaged problem formulation as joint researching and defining...... of a contemporary and complex problem by researchers and those who experience and know the problem. We present the formulated IT management problems and discuss the engaged problem formulation process in relation to engaged scholarship. Furthermore, we discuss how engaged problem formulation may contribute...

  13. 21 CFR 864.2875 - Balanced salt solutions or formulations. (United States)


    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Balanced salt solutions or formulations. 864.2875 Section 864.2875 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Cell And Tissue Culture Products § 864.2875...

  14. Exploring Chinese cultural standards through the lens of German managers: A case study approach

    Directory of Open Access Journals (Sweden)

    Roger Moser


    Full Text Available The ability to understand one’s own culture and to deal with specificities of foreign cultures is one of the core requirements in today’s international business. Management skills are partially culture specific and a management approach that is appropriate in one cultural context may not be appropriate in another. Several business activities of companies nowadays take place abroad, which requires managers to interact with different cultures. This paper aims to analyse cultural characteristics, especially in a Sino-German business context. Based on literature analysis and case study research, relevant cultural standards in China were identified from the German perspective. The result differentiates three superordinate cultural areas and five specific cultural standards and analyses different influence factors on the dimensions of the identified Chinese cultural standards.

  15. Quality by Design approach for studying the impact of formulation and process variables on product quality of oral disintegrating films. (United States)

    Mazumder, Sonal; Pavurala, Naresh; Manda, Prashanth; Xu, Xiaoming; Cruz, Celia N; Krishnaiah, Yellela S R


    The present investigation was carried out to understand the impact of formulation and process variables on the quality of oral disintegrating films (ODF) using Quality by Design (QbD) approach. Lamotrigine (LMT) was used as a model drug. Formulation variable was plasticizer to film former ratio and process variables were drying temperature, air flow rate in the drying chamber, drying time and wet coat thickness of the film. A Definitive Screening Design of Experiments (DoE) was used to identify and classify the critical formulation and process variables impacting critical quality attributes (CQA). A total of 14 laboratory-scale DoE formulations were prepared and evaluated for mechanical properties (%elongation at break, yield stress, Young's modulus, folding endurance) and other CQA (dry thickness, disintegration time, dissolution rate, moisture content, moisture uptake, drug assay and drug content uniformity). The main factors affecting mechanical properties were plasticizer to film former ratio and drying temperature. Dissolution rate was found to be sensitive to air flow rate during drying and plasticizer to film former ratio. Data were analyzed for elucidating interactions between different variables, rank ordering the critical materials attributes (CMA) and critical process parameters (CPP), and for providing a predictive model for the process. Results suggested that plasticizer to film former ratio and process controls on drying are critical to manufacture LMT ODF with the desired CQA. Published by Elsevier B.V.

  16. Validation of flexible multibody dynamics beam formulations using benchmark problems

    Energy Technology Data Exchange (ETDEWEB)

    Bauchau, Olivier A., E-mail: [University of Maryland (United States); Betsch, Peter [Karlsruhe Institute of Technology (Germany); Cardona, Alberto [CIMEC (UNL/Conicet) (Argentina); Gerstmayr, Johannes [Leopold-Franzens Universität Innsbruck (Austria); Jonker, Ben [University of Twente (Netherlands); Masarati, Pierangelo [Politecnico di Milano (Italy); Sonneville, Valentin [Université de Liège (Belgium)


    As the need to model flexibility arose in multibody dynamics, the floating frame of reference formulation was developed, but this approach can yield inaccurate results when elastic displacements becomes large. While the use of three-dimensional finite element formulations overcomes this problem, the associated computational cost is overwhelming. Consequently, beam models, which are one-dimensional approximations of three-dimensional elasticity, have become the workhorse of many flexible multibody dynamics codes. Numerous beam formulations have been proposed, such as the geometrically exact beam formulation or the absolute nodal coordinate formulation, to name just two. New solution strategies have been investigated as well, including the intrinsic beam formulation or the DAE approach. This paper provides a systematic comparison of these various approaches, which will be assessed by comparing their predictions for four benchmark problems. The first problem is the Princeton beam experiment, a study of the static large displacement and rotation behavior of a simple cantilevered beam under a gravity tip load. The second problem, the four-bar mechanism, focuses on a flexible mechanism involving beams and revolute joints. The third problem investigates the behavior of a beam bent in its plane of greatest flexural rigidity, resulting in lateral buckling when a critical value of the transverse load is reached. The last problem investigates the dynamic stability of a rotating shaft. The predictions of eight independent codes are compared for these four benchmark problems and are found to be in close agreement with each other and with experimental measurements, when available.

  17. Dimensions of Cultural Differences: Pancultural, ETIC/EMIC, and Ecological Approaches (United States)

    Stankov, Lazar; Lee, Jihyun


    We investigated the factorial structure of four major domains in social psychology (personality traits, social attitudes, values, and social norms) with an emphasis on cross-cultural differences. Three distinctive approaches--pancultural, multigroup, and multilevel--were applied to the data based on 22 measures that were collected from 2029…

  18. Does the Cultural Formulation Interview for the fifth revision of the diagnostic and statistical manual of mental disorders (DSM-5) affect medical communication? A qualitative exploratory study from the New York site. (United States)

    Aggarwal, Neil K; Desilva, Ravi; Nicasio, Andel V; Boiler, Marit; Lewis-Fernández, Roberto


    Cross-cultural mental health researchers often analyze patient explanatory models of illness to optimize service provision. The Cultural Formulation Interview (CFI) is a cross-cultural assessment tool released in May 2013 with DSM-5 to revise shortcomings from the DSM-IV Outline for Cultural Formulation (OCF). The CFI field trial took place in 6 countries, 14 sites, and with 321 patients to explore its feasibility, acceptability, and clinical utility with patients and clinicians. We sought to analyze if and how CFI feasibility, acceptability, and clinical utility were related to patient-clinician communication. We report data from the New York site which enrolled 7 clinicians and 32 patients in 32 patient-clinician dyads. We undertook a data analysis independent of the parent field trial by conducting content analyses of debriefing interviews with all participants (n = 64) based on codebooks derived from frameworks for medical communication and implementation outcomes. Three coders created codebooks, coded independently, established inter-rater coding reliability, and analyzed if the CFI affects medical communication with respect to feasibility, acceptability, and clinical utility. Despite racial, ethnical, cultural, and professional differences within our group of patients and clinicians, we found that promoting satisfaction through the interview, eliciting data, eliciting the patient's perspective, and perceiving data at multiple levels were common codes that explained how the CFI affected medical communication. We also found that all but two codes fell under the implementation outcome of clinical utility, two fell under acceptability, and none fell under feasibility. Our study offers new directions for research on how a cultural interview affects patient-clinician communication. Future research can analyze how the CFI and other cultural interviews impact medical communication in clinical settings with subsequent effects on outcomes such as medication adherence

  19. Beyond Diversity as Usual: Expanding Critical Cultural Approaches to Marginalization in Engineering Education (United States)

    Secules, Stephen

    In general, what we think of as "diversity work" in undergraduate engineering education focuses in the following ways: more on the overlooked assets of minority groups than on the acts of overlooking, more on the experiences of marginalized groups than on the mechanisms of marginalization by dominant groups, more on supporting and increasing minority student retention than on critiquing and remediating the systems which lead minority students to leave engineering. This dissertation presents a series of arguments which push beyond a status quo understanding of diversity in engineering education. The first approach the dissertation takes up is to problematize educational facts around failure by interrogating their roots in interactions and cultural norms in an engineering classroom. In another argument, the dissertation places the engineering classroom cultural norms of competition, whiteness, and masculinity in a critical historical context of the discipline at large. Finally, I demonstrate how engaging students in a critique of marginalizing educational culture can be an important source of agency. In addition to applying and demonstrating the value of specific novel approaches in engineering education, the dissertation contributes to the research community by discussing the respective affordances between these and other possible scholarly approaches to culture and marginalization in education. I also suggest how a consideration of the taken-for-granted culture of engineering education can be an important tool for instructors seeking to gain insight into persistent educational problems. In addition, this dissertation makes implications for diversity support practice, envisioning new forms of support programming rooted in intersectionality and critical praxis.

  20. Exploring Integrated Marketing Communications, Brand Awareness, and Brand Image in Hospitality Marketing: A Cross-Cultural Approach

    Directory of Open Access Journals (Sweden)

    Maja Šerić


    Full Text Available Purpose – The purpose of this paper is to assess customer perceptions of integration of marketing communications, brand awareness, and brand image in hospitality. Moreover, cross-cultural differences are considered when evaluating all the concepts, since national culture can have a considerable impact on customer behavior. Design/Methodology/Approach – After a literature review of the examined concepts, the results of an empirical study are presented and discussed. The empirical investigation was carried out by approaching 475 guests of upscale Croatian hotels. The SPSS software was employed for data analysis. Findings and implications – The results indicate that hotel guests assessed integrated marketing communications fairly highly. Brand image also reached relatively high scores, while the level of awareness of the brand was more moderate. Significant differences in perceptions among three delimited groups according to their national culture were found. The findings suggest that hotel managers should increase brand awareness and consider cross-cultural differences when implementing their business strategies. Limitations – A greater number of hotel guests according to their national culture should be approached to obtain more representative subsamples. Originality – The contribution of this work lies in examining three key marketing variables from the consumer point of view and under a cross-cultural approach. In particular, there has been little empirical evidence on IMC perceptions from the consumer perspective and hardly any considering the cultural background of the respondents. The contribution is also made to the hotel environment, as the variables were examined from the cross-cultural perspective, an issue that was completely neglected in the literature on hospitality marketing to date.

  1. Cross-cultural training as a source of competitive advantage

    Directory of Open Access Journals (Sweden)

    Alberto Mirabal Martínez


    Full Text Available The present article of a theoretical nature addresses cross-cultural training as a success factor to promote external adjustment. In that sense, a documentary and critical review of the subject, and the analysis pursuant to agency theories, transaction costs, and dynamic capacities allow the formulation of a body of propositions; the latter help to estimate, among other considerations, that the degree of effectiveness of the referred practice can not only differ according to cultural distance, type of expatriate employee, and strategic approach; but, as an unintended effect, the acquired technical and multicultural skills may be susceptible to personal benefit, when weaknesses in control mechanisms or inadequate human resources policies are conductive to the presence of opportunistic behavior or conflicts of interest between parties.

  2. A Comparison of Local and Global Formulations of Thermodynamics (United States)

    DeVoe, Howard


    Several educators have advocated teaching thermodynamics using a"global" approach in place of the conventional "local" approach. This article uses four examples of experiments to illustrate the two formulations and the definitions of heat and work associated with them. Advantages and disadvantages of both approaches are…

  3. Topology optimization of acoustic-structure interaction problems using a mixed finite element formulation

    DEFF Research Database (Denmark)

    Yoon, Gil Ho; Jensen, Jens Stissing; Sigmund, Ole


    given during the optimization process. In this paper we circumvent the explicit boundary representation by using a mixed finite element formulation with displacements and pressure as primary variables (a u/p-formulation). The Helmholtz equation is obtained as a special case of the mixed formulation...... for the elastic shear modulus equating to zero. Hence, by spatial variation of the mass density, shear and bulk moduli we are able to solve the coupled problem by the mixed formulation. Using this modelling approach, the topology optimization procedure is simply implemented as a standard density approach. Several...... two-dimensional acoustic-structure problems are optimized in order to verify the proposed method....

  4. Strengthening Safety Culture as an Overriding Priority, in Achieving Global Nuclear Security Approach

    International Nuclear Information System (INIS)

    Kolundzija, V.


    In the IAEA glossary safety culture is defined as the assembly of characteristics and attitudes in organizations and individuals, which establishes that, as an overriding priority, protection and safety issues receive the attention warranted by their significance. It has been observed that a safety culture, as a part of both security and safety, possesses a few obstacles that should be noticed: safety culture cannot be directly regulated; variation in national cultures means that what constitutes as a good approach to enhancing safety culture in one country may not be the best approach in another. Three stages have been identified in developing and strengthening safety culture: 1 A technical issue (rules and regulations)/ first stage 2 Good safety performance (primarily in terms of safety targets or goals)/ second stage 3 A continuing process of improvement to which everyone can contribute/ third stage There are several key issues in safety culture, such as: a commitment, use of procedures, a conservative decision making (STAR) a reporting culture. Organizations and individuals should have attention on these. Overall common goals are to achieve and maintain a high level of safety and security of radioactive sources as well as facilities. Measures that are concerned on safeguards restrict access to the radioactive sources, conditioning and/or recycling of sources, and systems for detection the passage of the radioactive sources at strategic points, have gained main support. The main partners in implementation these measures are: IAEA, USA, Russian Federation, G8- Global Partnership, and European Union The member states of the IAEA have at their disposal internationally agreed standards. Current differences in applying standards in the IAEA member states are mainly related to state preparedness to cope with demands. Developing and less developed countries with small and medium nuclear programmes have difficulties to accept rules and regulations, to establish

  5. Marxism in Vygotskian Approaches to Cultural Studies of Science Education (United States)

    Lima, Paulo, Jr.; Ostermann, Fernanda; Rezende, Flavia


    In this paper we initially address the main categories of Marxism, illustrating how Vygotsky has appropriated them as mediational meta-theoretical tools for building concepts for his psychological approach. In order to investigate the influence of Marxism in cultural studies of science education, we make an account of how current research,…

  6. Engaged Problem Formulation in IS Research

    DEFF Research Database (Denmark)

    Nielsen, Peter Axel; Persson, John Stouby


    problems requires a more substantial engagement with the different stakeholders, especially when their problems are ill structured and situated in complex organizational settings. On this basis, we present an engaged approach to formulating IS problems with, not for, IS practitioners. We have come...

  7. Fish consumption and track to a fish feed formulation (United States)

    Cai-Juan, Soong; Ramli, Razamin; Rahman, Rosshairy Abdul


    Strategically located in the equator, Malaysia is blessed with plenty of fish supply. The high demand in fish consumption has helped the development in the fishery industry and provided numerous jobs in the secondary sector, contributing significantly to the nation's income. A survey was conducted to understand the trend of current demands for fish for the purpose of designing a feed formulation, which is still limited in this area of study. Results showed that grouper fish in restaurants commanded a very high price compared to other species of fish. Tiger grouper gained the highest demand in most restaurants, while giant grouper had the highest price in restaurants. Due to the demand and challenges to culture this type of fish, a framework for fish feed formulation is proposed. The formulation framework when materialized could be an alternative to the use of trash fish as the feed for grouper.

  8. Magnetic Resonance Imaging to Visualize Disintegration of Oral Formulations. (United States)

    Curley, Louise; Hinton, Jordan; Marjoribanks, Cameron; Mirjalili, Ali; Kennedy, Julia; Svirskis, Darren


    This article demonstrates that magnetic resonance imaging can visualize the disintegration of a variety of paracetamol containing oral formulations in an in vitro setting and in vivo in the human stomach. The different formulations had unique disintegration profiles which could be imaged both in vitro and in vivo. No special formulation approaches or other contrast agents were required. These data demonstrate the potential for further use of magnetic resonance imaging to investigate and understand the disintegration behavior of different formulation types in vivo, and could potentially be used as a teaching tool in pharmaceutical and medical curricula. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  9. Does the Cultural Formulation Interview (CFI) for the Fifth Revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) affect medical communication? A qualitative exploratory study from the New York site (United States)

    Aggarwal, Neil K.; DeSilva, Ravi; Nicasio, Andel V.; Boiler, Marit; Lewis-Fernández, Roberto


    Objectives Cross-cultural mental health researchers often analyze patient explanatory models of illness to optimize service provision. The Cultural Formulation Interview (CFI) is a cross-cultural assessment tool released in May 2013 with DSM-5 to revise shortcomings from the DSM-IV Outline for Cultural Formulation (OCF). The CFI field trial took place in 6 countries, 14 sites, and with 321 patients to explore its feasibility, acceptability, and clinical utility with patients and clinicians. We sought to analyze if and how CFI feasibility, acceptability, and clinical utility were related to patient-clinician communication. Design We report data from the New York site which enrolled 7 clinicians and 32 patients in 32 patient-clinician dyads. We undertook a data analysis independent of the parent field trial by conducting content analyses of debriefing interviews with all participants (n=64) based on codebooks derived from frameworks for medical communication and implementation outcomes. Three coders created codebooks, coded independently, established inter-rater coding reliability, and analyzed if the CFI affects medical communication with respect to feasibility, acceptability, and clinical utility. Results Despite racial, ethnic, cultural, and professional differences within our group of patients and clinicians, we found that promoting satisfaction through the interview, eliciting data, eliciting the patient’s perspective, and perceiving data at multiple levels were common codes that explained how the CFI affected medical communication. We also found that all but 2 codes fell under the implementation outcome of clinical utility, 2 fell under acceptability, and none fell under feasibility. Conclusion Our study offers new directions for research on how a cultural interview affects patient-clinician communication. Future research can analyze how the CFI and other cultural interviews impact medical communication in clinical settings with subsequent effects on outcomes

  10. Stress, Burnout and Culture Shock: An Experiential, Pre-service Approach. (United States)

    Mungo, Samuel J.

    A carefully-monitored off-campus program for preservice teacher education students can be used as a preventive approach to teacher stress, burnout, and culture shock often experienced by practicing and beginning teachers. Anxiety, caused by a variety of reactions including low self image, threat to security, and fear, is a common element in stress…

  11. Assessing Adolescents' Understanding of and Reactions to Stress in Different Cultures: Results of a Mixed-Methods Approach (United States)

    Nastasi, Bonnie K.; Hitchcock, John H.; Burkholder, Gary; Varjas, Kristen; Sarkar, Sreeroopa; Jayasena, Asoka


    This article expands on an emerging mixed-method approach for validating culturally-specific constructs (see Hitchcock et al., 2005). Previous work established an approach for dealing with cultural impacts when assessing psychological constructs and the current article extends these efforts into studying stress reactions among adolescents in Sri…

  12. Sodium Lauryl Sulfate Increases the Efficacy of a Topical Formulation of Foscarnet against Herpes Simplex Virus Type 1 Cutaneous Lesions in Mice (United States)

    Piret, Jocelyne; Désormeaux, André; Cormier, Hélène; Lamontagne, Julie; Gourde, Pierrette; Juhász, Julianna; Bergeron, Michel G.


    The influence of sodium lauryl sulfate (SLS) on the efficacies of topical gel formulations of foscarnet against herpes simplex virus type 1 (HSV-1) cutaneous infection has been evaluated in mice. A single application of the gel formulation containing 3% foscarnet given 24 h postinfection exerted only a modest effect on the development of herpetic skin lesions. Of prime interest, the addition of 5% SLS to this gel formulation markedly reduced the mean lesion score. The improved efficacy of the foscarnet formulation containing SLS could be attributed to an increased penetration of the antiviral agent into the epidermis. In vitro, SLS decreased in a concentration-dependent manner the infectivities of herpesviruses for Vero cells. SLS also inhibited the HSV-1 strain F-induced cytopathic effect. Combinations of foscarnet and SLS resulted in subsynergistic to subantagonistic effects, depending on the concentration used. Foscarnet in phosphate-buffered saline decreased in a dose-dependent manner the viability of cultured human skin fibroblasts. This toxic effect was markedly decreased when foscarnet was incorporated into the polymer matrix. The presence of SLS in the gel formulations did not alter the viabilities of these cells. The use of gel formulations containing foscarnet and SLS could represent an attractive approach to the treatment of herpetic mucocutaneous lesions, especially those caused by acyclovir-resistant strains. PMID:10952566

  13. From a regulatory to a cultural approach in the field of radiological protection

    International Nuclear Information System (INIS)

    Boehler, M.-C.


    A radiological protection culture, which is seen to be a 'management' approach to individual and collective doses, based on the principle of optimisation is described with particular reference to the nuclear industry. The article discusses the fundamental role of the principle of optimisation, the legal nature of the principle of optimisation and the implementation of a radiological protection culture. (UK)

  14. Optimizing the co-feeding strategy of Persian sturgeon (Acipenser persicus larvae using Artemia nauplii and formulated diet

    Directory of Open Access Journals (Sweden)

    Naser Agh


    Full Text Available High mortality and labor costs are associated with first-feeding sturgeon culture, particularly during the period of dietary transition from live to formulated feed. Therefore we investigated the effects of various feeding treatments on the survival and growth of the Persian sturgeon (Acipenser persicus larvae during a 20-day culture period. Three replicate groups (250 fish/replicate of first-feeding larvae were fed according to four main feeding regimes: (1 live food (live nauplii of brine shrimp Artemia urmiana; (2 indirect transition (5 days live food followed by gradual transition to formulated diet; (3 direct transition (using different combinations of live and formulated diet from the start feeding onwards; (4 formulated feed (FD from the start feeding. Results indicated that growth and survival were higher in the indirect transition feeding regime than in other regimes. Based on our study, co-feeding of A. persicus should start five days after prior feeding with live food.

  15. A geometrically exact beam element based on the absolute nodal coordinate formulation

    International Nuclear Information System (INIS)

    Gerstmayr, Johannes; Matikainen, Marko K.; Mikkola, Aki M.


    In this study, Reissner's classical nonlinear rod formulation, as implemented by Simo and Vu-Quoc by means of the large rotation vector approach, is implemented into the framework of the absolute nodal coordinate formulation. The implementation is accomplished in the planar case accounting for coupled axial, bending, and shear deformation. By employing the virtual work of elastic forces similarly to Simo and Vu-Quoc in the absolute nodal coordinate formulation, the numerical results of the formulation are identical to those of the large rotation vector formulation. It is noteworthy, however, that the material definition in the absolute nodal coordinate formulation can differ from the material definition used in Reissner's beam formulation. Based on an analytical eigenvalue analysis, it turns out that the high frequencies of cross section deformation modes in the absolute nodal coordinate formulation are only slightly higher than frequencies of common shear modes, which are present in the classical large rotation vector formulation of Simo and Vu-Quoc, as well. Thus, previous claims that the absolute nodal coordinate formulation is inefficient or would lead to ill-conditioned finite element matrices, as compared to classical approaches, could be refuted. In the introduced beam element, locking is prevented by means of reduced integration of certain parts of the elastic forces. Several classical large deformation static and dynamic examples as well as an eigenvalue analysis document the equivalence of classical nonlinear rod theories and the absolute nodal coordinate formulation for the case of appropriate material definitions. The results also agree highly with those computed in commercial finite element codes

  16. Cross-cultural undergraduate medical education in North America: theoretical concepts and educational approaches. (United States)

    Reitmanova, Sylvia


    Cross-cultural undergraduate medical education in North America lacks conceptual clarity. Consequently, school curricula are unsystematic, nonuniform, and fragmented. This article provides a literature review about available conceptual models of cross-cultural medical education. The clarification of these models may inform the development of effective educational programs to enable students to provide better quality care to patients from diverse sociocultural backgrounds. The approaches to cross-cultural health education can be organized under the rubric of two specific conceptual models: cultural competence and critical culturalism. The variation in the conception of culture adopted in these two models results in differences in all curricular components: learning outcomes, content, educational strategies, teaching methods, student assessment, and program evaluation. Medical schools could benefit from more theoretical guidance on the learning outcomes, content, and educational strategies provided to them by governing and licensing bodies. More student assessments and program evaluations are needed in order to appraise the effectiveness of cross-cultural undergraduate medical education.

  17. Urbanity and Urbanization: An Interdisciplinary Review Combining Cultural and Physical Approaches

    Directory of Open Access Journals (Sweden)

    Christoph Schneider


    Full Text Available This review paper focuses on research schemes regarding urbanity and urbanization, and brings together both cultural and physical approaches. First, we review the cultural and social construction of urbanity (as related to urbanization in Germany. In the early 20th century, urbanity was mainly the result of identity derived from a historical perspective in cities. This has changed profoundly in recent decades as urbanity stems more and more from various urban lifestyles and the staging of societal experiences, as summarized in the German term, “Erlebnisgesellschaft” (thrill-seeking society. The discussion is extended by an assessment of the recent state of the art regarding physical urban research. The focus lies on different fields of research; we address topics such as biodiversity, urban climate, air pollution, and resilience, as well as their impact on urban planning and governance. In conclusion, in order to tackle recent developments and future challenges regarding social and environmental issues, an integrative approach urges novel cross- and inter-disciplinary research efforts in urban studies, including urban-rural linkages. A newly constituted assessment of urbanization and city quarter development is proposed; the assessment focuses on the conjoint analysis of mobility, “Energiewende” (energy transition, cultural drivers, demographic development, and environmental issues.

  18. Developing a Plant Culture Medium Composed of Vinasse Originating from Haematococcus Pluvialis Culture

    International Nuclear Information System (INIS)

    Gollo, A. L.; Silva, A. L. L. D.; Lima, K. K. D. D.; Camara, M. C.; Rodrigues, C.; Vandenberghe, L. P. D. S.; Soccol, V. T.; Soccol, C. R.; Biasi, L. A.


    The mineral nutrients in vinasse provide support for algal and plant growth. Algal culture releases organic compounds into its liquid culture medium. These organic and inorganic substances can be useful for formulating a plant tissue culture medium, because tissue culture medium is composed of organic and inorganic components. Therefore, the aims of this study were to develop a plant culture medium by using the vinasse that is employed for Haematococcus pluvialis culture (algal filtrate); to investigate the possible beneficial effects of the biocompounds in the micropropagation of Nidularium procerum (Bromeliaceae), to evaluate quercetin content, total phenolics content in vinasse and to evaluate the cytotoxicity of the media by performing a bioassay with Artemia salina. The vinasse that originated from H. pluvialis culture can be used to formulate plant tissue culture at a 3% dilution, and its mineral nutrients can support In vitro plant growth, but some nutrients must be supplemented to enhance its efficiency. An efficient micropropagation protocol was developed for N. procerum. The micropropagated plants were suitable for transfer to the field (they were acclimatized). This culture medium provides a way to reuse wastewater, gives a rational alternative to vinasse disposal and adds value to what is currently considered to be an undesirable residue. Moreover, this process can reduce the production costs of clonal seedlings and/or bioactive compounds in biofactories. There was no apparent biostimulatory effect by the algal filtrate on morphogenesis; however, it did increase quercetin production. The H. pluvialis culture that was grown in the vinasse decreased the cytotoxicity and phenolic compound contents, which prevented explant tissue necrosis and represented a treatment for this residue for safer disposal in the environment. (author)

  19. Element free Galerkin formulation of composite beam with longitudinal slip

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, Dzulkarnain; Mokhtaram, Mokhtazul Haizad [Department of Civil Engineering, Universiti Selangor, Bestari Jaya, Selangor (Malaysia); Badli, Mohd Iqbal; Yassin, Airil Y. Mohd [Faculty of Civil Engineering, Universiti Teknologi Malaysia, Skudai, Johor (Malaysia)


    Behaviour between two materials in composite beam is assumed partially interact when longitudinal slip at its interfacial surfaces is considered. Commonly analysed by the mesh-based formulation, this study used meshless formulation known as Element Free Galerkin (EFG) method in the beam partial interaction analysis, numerically. As meshless formulation implies that the problem domain is discretised only by nodes, the EFG method is based on Moving Least Square (MLS) approach for shape functions formulation with its weak form is developed using variational method. The essential boundary conditions are enforced by Langrange multipliers. The proposed EFG formulation gives comparable results, after been verified by analytical solution, thus signify its application in partial interaction problems. Based on numerical test results, the Cubic Spline and Quartic Spline weight functions yield better accuracy for the EFG formulation, compares to other proposed weight functions.

  20. The past, present, and future of health development campaigns: reflexivity and the critical-cultural approach. (United States)

    Dutta, Mohan Jyoti; de Souza, Rebecca


    In contemporary society, health issues have gained increasing urgency in both political and academic spheres. Looking back at the failure of the modernist development initiatives, there is the need to realize that we live in a time of increasing sociopolitical complexity. The present moment is perhaps best understood in terms of a complex tension and linkage between the past and present, global and local, modern and postmodern. The critical-cultural approach to health campaigns is an approach that, through the reflexive interrogation of modernist assumptions underlying health communication campaigns, attempts to foreground the tensions inherent in the practice of health campaigns. This essay discusses the manner in which the critical-cultural approach interrogates modernist assumptions and provides an alternative paradigm for approaching the theory and practice of health campaigns by suggesting the necessity for reflexivity. Specifically, we discuss how the perspective interrogates the role of the media in development, the significance of culture, the locus of health responsibility, the impact of structural conditions, and the politics of knowledge, providing examples of campaigns that illustrate this reflexivity.

  1. Recent advances in cross-cultural measurement in psychiatric epidemiology: utilizing 'what matters most' to identify culture-specific aspects of stigma. (United States)

    Yang, Lawrence Hsin; Thornicroft, Graham; Alvarado, Ruben; Vega, Eduardo; Link, Bruce George


    While stigma measurement across cultures has assumed growing importance in psychiatric epidemiology, it is unknown to what extent concepts arising from culture have been incorporated. We utilize a formulation of culture-as the everyday interactions that 'matter most' to individuals within a cultural group-to identify culturally-specific stigma dynamics relevant to measurement. A systematic literature review from January 1990 to September 2012 was conducted using PsycINFO, Medline and Google Scholar to identify articles studying: (i) mental health stigma-related concepts; (ii) ≥ 1 non-Western European cultural group. From 5292 abstracts, 196 empirical articles were located. The vast majority of studies (77%) utilized adaptations of existing Western-developed stigma measures to new cultural groups. Extremely few studies (2.0%) featured quantitative stigma measures derived within a non-Western European cultural group. A sizeable amount (16.8%) of studies employed qualitative methods to identify culture-specific stigma processes. The 'what matters most' perspective identified cultural ideals of the everyday activities that comprise 'personhood' of 'preserving lineage' among specific Asian groups, 'fighting hard to overcome problems and taking advantage of immigration opportunities' among specific Latino-American groups, and 'establishing trust among religious institutions due to institutional discrimination' among African-American groups. These essential cultural interactions shaped culture-specific stigma manifestations. Mixed method studies (3.6%) corroborated these qualitative results. Quantitatively-derived, culturally-specific stigma measures were lacking. Further, the vast majority of qualitative studies on stigma were conducted without using stigma-specific frameworks. We propose the 'what matters most' approach to address this key issue in future research.

  2. Grid refinement model in lattice Boltzmann method for stream function-vorticity formulations

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Myung Seob [Dept. of Mechanical Engineering, Dongyang Mirae University, Seoul (Korea, Republic of)


    In this study, we present a grid refinement model in the lattice Boltzmann method (LBM) for two-dimensional incompressible fluid flow. That is, the model combines the desirable features of the lattice Boltzmann method and stream function-vorticity formulations. In order to obtain an accurate result, very fine grid (or lattice) is required near the solid boundary. Therefore, the grid refinement model is used in the lattice Boltzmann method for stream function-vorticity formulation. This approach is more efficient in that it can obtain the same accurate solution as that in single-block approach even if few lattices are used for computation. In order to validate the grid refinement approach for the stream function-vorticity formulation, the numerical simulations of lid-driven cavity flows were performed and good results were obtained.

  3. Genetic programming based models in plant tissue culture: An addendum to traditional statistical approach. (United States)

    Mridula, Meenu R; Nair, Ashalatha S; Kumar, K Satheesh


    In this paper, we compared the efficacy of observation based modeling approach using a genetic algorithm with the regular statistical analysis as an alternative methodology in plant research. Preliminary experimental data on in vitro rooting was taken for this study with an aim to understand the effect of charcoal and naphthalene acetic acid (NAA) on successful rooting and also to optimize the two variables for maximum result. Observation-based modelling, as well as traditional approach, could identify NAA as a critical factor in rooting of the plantlets under the experimental conditions employed. Symbolic regression analysis using the software deployed here optimised the treatments studied and was successful in identifying the complex non-linear interaction among the variables, with minimalistic preliminary data. The presence of charcoal in the culture medium has a significant impact on root generation by reducing basal callus mass formation. Such an approach is advantageous for establishing in vitro culture protocols as these models will have significant potential for saving time and expenditure in plant tissue culture laboratories, and it further reduces the need for specialised background.

  4. A duty-period-based formulation of the airline crew scheduling problem

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, K.


    We present a new formulation of the airline crew scheduling problem that explicitly considers the duty periods. We suggest an algorithm for solving the formulation by a column generation approach with branch-and-bound. Computational results are reported for a number of test problems.

  5. A methodology for building culture and gender norms into intervention: an example from Mumbai, India. (United States)

    Kostick, Kristin M; Schensul, Stephen L; Singh, Rajendra; Pelto, Pertti; Saggurti, Niranjan


    This paper responds to the call for culturally-relevant intervention research by introducing a methodology for identifying community norms and resources in order to more effectively implement sustainable interventions strategies. Results of an analysis of community norms, specifically attitudes toward gender equity, are presented from an HIV/STI research and intervention project in a low-income community in Mumbai, India (2008-2012). Community gender norms were explored because of their relevance to sexual risk in settings characterized by high levels of gender inequity. This paper recommends approaches that interventionists and social scientists can take to incorporate cultural insights into formative assessments and project implementation These approaches include how to (1) examine modal beliefs and norms and any patterned variation within the community; (2) identify and assess variation in cultural beliefs and norms among community members (including leaders, social workers, members of civil society and the religious sector); and (3) identify differential needs among sectors of the community and key types of individuals best suited to help formulate and disseminate culturally-relevant intervention messages. Using a multi-method approach that includes the progressive translation of qualitative interviews into a quantitative survey of cultural norms, along with an analysis of community consensus, we outline a means for measuring variation in cultural expectations and beliefs about gender relations in an urban community in Mumbai. Results illustrate how intervention strategies and implementation can benefit from an organic (versus a priori and/or stereotypical) approach to cultural characteristics and analysis of community resources and vulnerabilities. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. Safety culture as an element of contact and cooperation between utilities, research and safety authorities

    International Nuclear Information System (INIS)

    Hoegberg, L.


    The safety culture approach may simply be seen as a recognition of the close interdependence between safety and organisational processes: achievement of technical safety objectives will largely depend on the quality of the implementation processes in the organisations concerned. With a slight modification of the original INSAG formulation, SKI defines safety culture as 'a consciously formulated and implemented set of values in an organisation, which establishes that, as an overriding priority, safety issues receive the attention warranted by their significance'. In practice, a high level of safety culture means the systematic organisation and implementation of a number of activities aimed at creating a high quality defence in depth against both technical and human failures that may cause accidents. An enquiring and learning attitude is a key element of such a safety culture. For example, to prevent accidents, the organisation always needs to be reactive to incidents, by performing proper root cause analysis of both technical and organisational factors, and taking appropriate corrective actions. The long term organisational objective should be to be proactive and identify deficiencies in technology and organisation that may lead to serious incidents or, at worst, accidents and take corrective action even before actual occurrence of incidents of substantial safety significance. (author) 13 refs

  7. Fusarium diversity in soil using a specific molecular approach and a cultural approach. (United States)

    Edel-Hermann, Véronique; Gautheron, Nadine; Mounier, Arnaud; Steinberg, Christian


    Fusarium species are ubiquitous in soil. They cause plant and human diseases and can produce mycotoxins. Surveys of Fusarium species diversity in environmental samples usually rely on laborious culture-based methods. In the present study, we have developed a molecular method to analyze Fusarium diversity directly from soil DNA. We designed primers targeting the translation elongation factor 1-alpha (EF-1α) gene and demonstrated their specificity toward Fusarium using a large collection of fungi. We used the specific primers to construct a clone library from three contrasting soils. Sequence analysis confirmed the specificity of the assay, with 750 clones identified as Fusarium and distributed among eight species or species complexes. The Fusarium oxysporum species complex (FOSC) was the most abundant one in the three soils, followed by the Fusarium solani species complex (FSSC). We then compared our molecular approach results with those obtained by isolating Fusarium colonies on two culture media and identifying species by sequencing part of the EF-1α gene. The 750 isolates were distributed into eight species or species complexes, with the same dominant species as with the cloning method. Sequence diversity was much higher in the clone library than in the isolate collection. The molecular approach proved to be a valuable tool to assess Fusarium diversity in environmental samples. Combined with high throughput sequencing, it will allow for in-depth analysis of large numbers of samples. Published by Elsevier B.V.


    Directory of Open Access Journals (Sweden)

    Lígia Márcia Martins


    Full Text Available This article puts in question the affectional-cognitive unit which sustains the human activity, with the purpose to light incorrectness of approaches which dichotomize reason and emotion. It asserts that such dissociations are founded in theorical-methodological principles which set bounds for explanations about the human psychism, so that the overcoming of referred dualisms puts on as a method matter. For making explicit that assertion, it resorted to Historic-Cultural Psychology, based on that it explains about the psychism as subjective image of objective reality, of Vygotskyan criticisms to Cartesian dualism and the need of a historic-cultural approach on emotion studies, intend to analyzing the human activity as a affective-cognitive unit and the imbricated relations that are waged, within it, among affections, emotions, feelings and thoughts. Once presented the interrelations between emotions and cognitions this exhibition argues that the concepts are necessary as a minimum unit of analysis both of thought and feelings.

  9. A new formulation of non-relativistic diffeomorphism invariance

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, Rabin, E-mail: [S.N. Bose National Centre for Basic Sciences, JD Block, Sector III, Salt Lake City, Kolkata-700 098 (India); Mitra, Arpita, E-mail: [S.N. Bose National Centre for Basic Sciences, JD Block, Sector III, Salt Lake City, Kolkata-700 098 (India); Mukherjee, Pradip, E-mail: [Department of Physics, Barasat Government College, Barasat, West Bengal (India)


    We provide a new formulation of non-relativistic diffeomorphism invariance. It is generated by localising the usual global Galilean symmetry. The correspondence with the type of diffeomorphism invariant models currently in vogue in the theory of fractional quantum Hall effect has been discussed. Our construction is shown to open up a general approach of model building in theoretical condensed matter physics. Also, this formulation has the capacity of obtaining Newton–Cartan geometry from the gauge procedure.

  10. Assessment of strategy formulation

    DEFF Research Database (Denmark)

    Acur, Nuran; Englyst, Linda


    of the success criteria through face-to-face interviews with 46 managers, workshops involving 40 managers, and two in-depth case studies. The success criteria have been slightly modified due to the empirical results, to yield the assessment tool. Findings – The resulting assessment tool integrates three generic...... approaches to strategy assessment, namely the goal-centred, comparative and improvement approaches, as found in the literature. Furthermore, it encompasses three phases of strategy formulation processes: strategic thinking, strategic planning and embedding of strategy. The tool reflects that the different......, but cases and managerial perceptions indicate that the need for accurate and detailed plans might be overrated in the literature, as implementation relies heavily on continuous improvement and empowerment. Concerning embedding, key aspects relate both to the goal-centred and improvement approaches, while...

  11. The geometry of the SLsub(2,c) gauge formulation of general relativity

    International Nuclear Information System (INIS)

    Kaye, M.


    The formulation of Einstein's general theory of relativity as an SLsub(2,c) gauge theory is considered. Use is made of the language of fibre bundles and general arguments are put forward in favour of the SLsub(2,c) approach to problems connected with the study of the space-time structure. The possibility of deriving the dynamics of the theory from a Yang-Mills-type Lagrangian density is discussed. Finally, the spinor approach is compared with other approaches to the problem of formulating Einstein's theory as a gauge theory

  12. Projecting India's energy requirements for policy formulation

    International Nuclear Information System (INIS)

    Parikh, Kirit S.; Karandikar, Vivek; Rana, Ashish; Dani, Prasanna


    Energy policy has to have a long-term perspective. To formulate it one needs to know the contours of energy requirements and options. Different approaches have been followed in literature, each with their own problems. A top down econometric approach provides little guidance on policies, while a bottom up approval requires too much knowledge and too many assumptions. Using top-down econometric approach for aggregate overall benchmarking and a detailed activity analysis model, Integrated Energy System Model, for a few large sectors, provides a unique combination for easing the difficulties of policy formulation. The model is described in this paper. Eleven alternate scenarios are built, designed to map out extreme points of feasible options. Results show that even after employing all domestic energy resource to their full potential, there will be a continued rise of fossil fuel use, continued importance of coal, and continued rise of import dependence. Energy efficiency emerges as a major option with a potential to reduce energy requirement by as much as 17%. Scenario results point towards pushing for development of alternative sources. (author)

  13. Non-Invasive Optical Sensor Based Approaches for Monitoring Virus Culture to Minimize BSL3 Laboratory Entry

    Directory of Open Access Journals (Sweden)

    Viswanath Ragupathy


    Full Text Available High titers of infectious viruses for vaccine and diagnostic reference panel development are made by infecting susceptible mammalian cells. Laboratory procedures are strictly performed in a Bio-Safety Level-3 (BSL3 laboratory and each entry and exit involves the use of  disposable Personnel Protective Equipment (PPE to observe cell culture conditions. Routine PPE use involves significant recurring costs. Alternative non-invasive optical sensor based approaches to remotely monitor cell culture may provide a promising and cost effective approach to monitor infectious virus cultures resulting in lower disruption and costs. We report here the monitoring of high titer cultures of Human Immunodeficiency Virus-1 (HIV-1 and Herpes Simplex Virus-2 (HSV-2 remotely with the use of optical oxygen sensors aseptically placed inside the cell culture vessel. The replacement of culture media for cell and virus propagation and virus load monitoring was effectively performed using this fluorescent sensor and resulted in half the number of visits to the BSL3 lab (five versus ten.

  14. Comparison of algebraic and analytical approaches to the formulation of the statistical model-based reconstruction problem for X-ray computed tomography. (United States)

    Cierniak, Robert; Lorent, Anna


    The main aim of this paper is to investigate properties of our originally formulated statistical model-based iterative approach applied to the image reconstruction from projections problem which are related to its conditioning, and, in this manner, to prove a superiority of this approach over ones recently used by other authors. The reconstruction algorithm based on this conception uses a maximum likelihood estimation with an objective adjusted to the probability distribution of measured signals obtained from an X-ray computed tomography system with parallel beam geometry. The analysis and experimental results presented here show that our analytical approach outperforms the referential algebraic methodology which is explored widely in the literature and exploited in various commercial implementations. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids

    International Nuclear Information System (INIS)

    Kapur, S K; Wang, X; Shang, H; Yun, S; Li, X; Feng, G; Khurgel, M; Katz, A J


    Adipose-derived stromal/stem cells (ASCs) have been gaining recognition as an extremely versatile cell source for tissue engineering. The usefulness of ASCs in biofabrication is further enhanced by our demonstration of the unique properties of these cells when they are cultured as three-dimensional cellular aggregates or spheroids. As described herein, three-dimensional formulations, or self-assembling ASC spheroids develop their own extracellular matrix that serves to increase the robustness of the cells to mechanical stresses. The composition of the extracellular matrix can be altered based on the external environment of the spheroids and these constructs can be grown in a reproducible manner and to a consistent size. The spheroid formulation helps preserve the viability and developmental plasticity of ASCs even under defined, serum-free media conditions. For the first time, we show that multiple generations of adherent ASCs produced from these spheroids retain their ability to differentiate into multiple cell/tissue types. These demonstrated properties support the idea that culture-expanded ASCs are an excellent candidate cellular material for ‘organ printing’—the approach of developing complex tissue structures from a standardized cell ‘ink’ or cell formulation. (paper)

  16. A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture. (United States)

    Risso, Davide S; Giuliani, Cristina; Antinucci, Marco; Morini, Gabriella; Garagnani, Paolo; Tofanelli, Sergio; Luiselli, Donata


    The study of food choice, one of the most complex human traits, requires an integrated approach that takes into account environmental, socio-cultural and biological diversity. We recruited 183 volunteers from four geo-linguistic groups and highly diversified in terms of both genetic background and food habits from whom we collected genotypes and phenotypes tightly linked to taste perception. We confirmed previous genetic associations, in particular with stevioside perception, and noted significant differences in food consumption: in particular, broccoli, mustard and beer consumption scores were significantly higher (Adjusted P = 0.02, Adjusted P diversity and cultural aspects in taste perception and food consumption. Published by Elsevier Ltd.

  17. Intersubjective Culture: The Role of Intersubjective Perceptions in Cross-Cultural Research. (United States)

    Chiu, Chi-Yue; Gelfand, Michele J; Yamagishi, Toshio; Shteynberg, Garriy; Wan, Ching


    Intersubjective perceptions refer to shared perceptions of the psychological characteristics that are widespread within a culture. In this article, we propose the intersubjective approach as a new approach to understanding the role that culture plays in human behavior. In this approach, intersubjective perceptions, which are distinct from personal values and beliefs, mediate the effect of the ecology on individuals' responses and adaptations. We review evidence that attests to the validity and utility of the intersubjective approach in explicating culture's influence on human behaviors and discuss the implications of this approach for understanding the interaction between the individual, ecology, and culture; the nature of cultural competence; management of multicultural identities; cultural change; and measurement of culture. © The Author(s) 2010.

  18. Redefining Organizational Cultures: An Interpretative Anthropological Approach to Corporate Narratives

    Directory of Open Access Journals (Sweden)

    Jasmin Mahadevan


    Full Text Available Hardly any management theory nowadays fails to take culture's influence on today's organizations into account. At the very foundation lies the belief that the intercultural boundary can be determined externally—by etic view. In my paper I show how much emic organizational reality differs from etic view. Hereby, I refer to two years of fieldwork that I conducted in a global high-tech company at sites in Germany, Austria and India. I choose this approach to trace culture as an open process of sense-making in practice. Through interpretative anthropological means, I identified several discourses of collective identity that were constructed narratively—often regardless of the presumed etic border of "Germans" vs. "Indians." In summary, this paper makes the following contributions: Firstly, it shows how emic and etic categorizations of the cultural other can differ in a complex environment. Secondly, it looks in depth into the emic categorizations of "the Other" and how they are constructed narratively. Thirdly, it draws conclusions for the field of intercultural communication. URN: urn:nbn:de:0114-fqs0901440

  19. Refining stability and dissolution rate of amorphous drug formulations

    DEFF Research Database (Denmark)

    Grohganz, Holger; Priemel, Petra A; Löbmann, Korbinian


    Introduction: Poor aqueous solubility of active pharmaceutical ingredients (APIs) is one of the main challenges in the development of new small molecular drugs. Additionally, the proportion of poorly soluble drugs among new chemical entities is increasing. The transfer of a crystalline drug to its...... and on the interaction of APIs with small molecular compounds rather than polymers. Finally, in situ formation of an amorphous form might be an option to avoid storage problems altogether. Expert opinion: The diversity of poorly soluble APIs formulated in an amorphous drug delivery system will require different...... approaches for their stabilisation. Thus, increased focus on emerging techniques can be expected and a rational approach to decide the correct formulation is needed....

  20. Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia. (United States)

    Korčok, Davor Jovan; Tršić-Milanović, Nada Aleksandar; Ivanović, Nevena Djuro; Đorđević, Brižita Ivan


    Probiotics are increasingly more present both as functional foods, and in pharmaceutical preparations with multiple levels of action that contribute to human health. Probiotics realize their positive effects with a proper dose, and by maintaining a declared number of probiotics cells by the expiration date. Important precondition for developing a probiotic product is the right choice of clinically proven probiotic strain, the choice of other active components, as well as, the optimization of the quantity of active component of probiotic per product dose. This scientific paper describes the optimization of the number of probiotics cells in the formulation of dietary supplement that contains probiotic culture Lactobacillus plantarum 299v, iron and vitamin C. Variations of the quantity of active component were analyzed in development batches of the encapsulated probiotic product categorized as dietary supplement with the following ingredients: probiotic culture, sucrosomal form of iron and vitamin C. Optimal quantity of active component L. plantarum of 50 mg, was selected. The purpose of this scientific paper is to select the optimal formulation of probiotic culture in a dietary supplement that contains iron and vitamin C, and to also determine its expiration date by the analysis of the number of viable probiotic cells.

  1. Towards a methodology to formulate sustainable diets for livestock: accounting for environmental impact in diet formulation. (United States)

    Mackenzie, S G; Leinonen, I; Ferguson, N; Kyriazakis, I


    The objective of this study was to develop a novel methodology that enables pig diets to be formulated explicitly for environmental impact objectives using a Life Cycle Assessment (LCA) approach. To achieve this, the following methodological issues had to be addressed: (1) account for environmental impacts caused by both ingredient choice and nutrient excretion, (2) formulate diets for multiple environmental impact objectives and (3) allow flexibility to identify the optimal nutritional composition for each environmental impact objective. An LCA model based on Canadian pig farms was integrated into a diet formulation tool to compare the use of different ingredients in Eastern and Western Canada. By allowing the feed energy content to vary, it was possible to identify the optimum energy density for different environmental impact objectives, while accounting for the expected effect of energy density on feed intake. A least-cost diet was compared with diets formulated to minimise the following objectives: non-renewable resource use, acidification potential, eutrophication potential, global warming potential and a combined environmental impact score (using these four categories). The resulting environmental impacts were compared using parallel Monte Carlo simulations to account for shared uncertainty. When optimising diets to minimise a single environmental impact category, reductions in the said category were observed in all cases. However, this was at the expense of increasing the impact in other categories and higher dietary costs. The methodology can identify nutritional strategies to minimise environmental impacts, such as increasing the nutritional density of the diets, compared with the least-cost formulation.

  2. An adhesive contact mechanics formulation based on atomistically induced surface traction

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Houfu [Department of Civil and Environmental Engineering, University of California, Berkeley, CA 94720 (United States); Ren, Bo [Livermore Software Technology Corporation, 7374 Las Positas Road, Livermore, CA 94551 (United States); Li, Shaofan, E-mail: [Department of Civil and Environmental Engineering, University of California, Berkeley, CA 94720 (United States)


    In this work, we have developed a novel multiscale computational contact formulation based on the generalized Derjuguin approximation for continua that are characterized by atomistically enriched constitutive relations in order to study macroscopic interaction between arbitrarily shaped deformable continua. The proposed adhesive contact formulation makes use of the microscopic interaction forces between individual particles in the interacting bodies. In particular, the double-layer volume integral describing the contact interaction (energy, force vector, matrix) is converted into a double-layer surface integral through a mathematically consistent approach that employs the divergence theorem and a special partitioning technique. The proposed contact model is formulated in the nonlinear continuum mechanics framework and implemented using the standard finite element method. With no large penalty constant, the stiffness matrix of the system will in general be well-conditioned, which is of great significance for quasi-static analysis. Three numerical examples are presented to illustrate the capability of the proposed method. Results indicate that with the same mesh configuration, the finite element computation based on the surface integral approach is faster and more accurate than the volume integral based approach. In addition, the proposed approach is energy preserving even in a very long dynamic simulation.

  3. New formulations of ready-to-use foods

    International Nuclear Information System (INIS)

    Dibari, Filippo; Akomo, Peter; Collins, Steve; Bahwere, Paluku


    Development of improved Ready-to-Use Therapeutic Foods (RUTFs) is a priority since the endorsement of the Community-based Management of Acute Malnutrition (CMAM). The most commonly used formulation is based on peanut and milk powder, but the following issues need to be addressed: acceptability is low in certain cultural contexts; milk powder is very expensive (about 50% of the total ingredient cost) and therefore it constraints the scaling up of local/regional production; peanut are often prone to aflatoxin contamination. Therefore, Valid International developed and trialled alternative RUTF formulations based on locally available and/or cheaper ingredients: Chickpea- and Sesame-based RUTF (CS-RUTF), Soya-, Maize, Sorghum-based RUTF (SMS-RUTF), and Whey Protein-based RUTF (WPC-RUTF). In Malawi, an observational study highlighted that CS-RUTF was effective in reversing HIV wasting in adults, and bio-electrical impedance measurements suggested a positive direct correlation between weight gain and free fat mass. In the same country, a randomized controlled trial demonstrated that WPC-RUTF was not inferior to the standard peanut and milk-based formulation (P-RUTF) when rehabilitating children under five years of age from severe acute malnutrition (SAM). In other two similar studies conducted in Zambia and Democratic Republic of Congo, SMS-RUTF and P-RUTF were equivalently efficient in rehabilitating SAM in children aged 2 to 5 years, but not in those below 2 years. In this presentation, we will (i) describe the procedures used for the development of the RUTF formulations, (ii) share successes and challenges encountered in formulating lower cost prototypes that meet international standards, (iii) suggest ways to reduce effect of anti-nutrients, to enhance bioavailability of crucial micronutrients (e.g. iron), and minimize abdominal discomfort. Based on results from efficacy and effectiveness trials, we will discuss their implications for policy-making and implementation

  4. Appendix A: The components of the culture media. (United States)

    Loyola-Vargas, Víctor M


    The success in the technology and application of plant tissue culture is greatly influenced by the nature of the culture medium used. A better understanding of the nutritional requirements of cultured cells and tissues can help to choose the most appropriate culture medium for the explant used. It is also important to pay attention to a number of inaccuracies and errors which have appeared in several widely used plant tissue culture basal medium formulations.

  5. Rectal budesonide and mesalamine formulations in active ulcerative proctosigmoiditis: efficacy, tolerance, and treatment approach

    Directory of Open Access Journals (Sweden)

    Christophi GP


    Full Text Available George P Christophi, Arvind Rengarajan, Matthew A Ciorba Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA Abstract: Ulcerative colitis (UC is an immune-mediated disease of the colon that is characterized by diffuse and continuous inflammation contiguous from the rectum. Half of UC patients have inflammation limited to the distal colon (proctitis or proctosigmoiditis that primarily causes symptoms of bloody diarrhea and urgency. Mild-to-moderate distal UC can be effectively treated with topical formulations (rectal suppositories, enemas, or foam of mesalamine or steroids to reduce mucosal inflammation and alleviate symptoms. Enemas or foam formulations adequately reach up to the splenic flexure, have a minimal side-effect ­profile, and induce remission alone or in combination with systemic immunosuppressive therapy. Herein, we compare the efficacy, cost, patient tolerance, and side-effect profiles of steroid and mesalamine rectal formulations in distal UC. Patients with distal mild-to-moderate UC have a remission rate of approximately 75% (NNT =2 after treatment for 6 weeks with mesalamine enemas. Rectal budesonide foam induces remission in 41.2% of patients with mild-to-moderate active distal UC compared to 24% of patient treated with placebo (NNT =5. However, rectal budesonide has better patient tolerance profile compared to enema formulations. Despite its favorable efficacy, safety, and cost profiles, patients and physicians significantly underuse topical treatments for treating distal colitis. This necessitates improved patient education and physician familiarity regarding the indications, effectiveness, and potential financial and tolerability barriers in using rectal formulations. Keywords: inflammatory bowel disease, treatment cost effectiveness, Crohn’s disease, ulcerative colitis, colon mucosa, proctitis suppositories, topical immunosuppressive therapy

  6. Different Strokes for Different Folks? Contrasting Approaches to Cultural Adaptation of Parenting Interventions. (United States)

    Mejia, Anilena; Leijten, Patty; Lachman, Jamie M; Parra-Cardona, José Ruben


    Relevant achievements have been accomplished in prevention science with regard to disseminating efficacious parenting interventions among underserved populations. However, widespread disparities in availability of parenting services continue to negatively impact diverse populations in high-income countries (e.g., the USA) and low- and middle-income countries. As a result, a scholarly debate on cultural adaptation has evolved over the years. Specifically, some scholars have argued that in diverse cultural contexts, existing evidence-based parenting interventions should be delivered with strict fidelity to ensure effectiveness. Others have emphasized the need for cultural adaptations of interventions when disseminated among diverse populations. In this paper, we propose that discussions on cultural adaptation should be conceptualized as a "both-and," rather than an "either-or" process. To justify this stance, we describe three distinct parenting intervention projects to illustrate how cultural adaptation and efficacy of evidence-based interventions can be achieved using contrasting approaches and frameworks, depending on cultural preferences and available resources of local contexts. Further, we suggest the need to develop guidelines for consistent reporting of cultural adaptation procedures as a critical component of future investigations. This discussion is relevant for the broader public health field and prevention science.

  7. An Approach to Enhancement of the Safety Culture of Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The culture of an organization is very complex to study and evaluate, but it is possible to examine the specific norms that figure out the culture for the safety of a system. This paper describes an initiation plan to study the safety culture issue in Korean NPPs. Recently there happened successively events that turned out to be socially prominent in Korea. Many issues on the safety culture aspect of NPPs have been raised including the types of errors such as violations, an intended concealment of safety-related information, counterfeit items, forgery process in procurement, and so on. Those were investigated in detail for the root causes of these issues as human and organizational errors and for the countermeasures to prevent those events. They are integrated into a correspondent long-term plan including the establishment of a fundamental infrastructure of safety culture management for operating NPPs in Korea. A monitoring system with analysis functions utilizing system dynamics simulation and data mining is proposed to be incorporated into a safety culture management system. Additionally, a set of training and support programs are to be developed for the enhancement of some selected competence of the operating personnel in Korean NPPs. The safe operation of NPPs requires the typical safety culture characteristics of the high reliability organization (HRO). The culture of an organization is very complex to study and evaluate, but it is possible to examine the specific norms that figure out the culture for the safety of a system. This paper describes an integrated systems approach as an initiating plan to study the safety culture issue in Korean NPPs.

  8. An Approach to Enhancement of the Safety Culture of Nuclear Power Plants

    International Nuclear Information System (INIS)

    Lee, Yong Hee


    The culture of an organization is very complex to study and evaluate, but it is possible to examine the specific norms that figure out the culture for the safety of a system. This paper describes an initiation plan to study the safety culture issue in Korean NPPs. Recently there happened successively events that turned out to be socially prominent in Korea. Many issues on the safety culture aspect of NPPs have been raised including the types of errors such as violations, an intended concealment of safety-related information, counterfeit items, forgery process in procurement, and so on. Those were investigated in detail for the root causes of these issues as human and organizational errors and for the countermeasures to prevent those events. They are integrated into a correspondent long-term plan including the establishment of a fundamental infrastructure of safety culture management for operating NPPs in Korea. A monitoring system with analysis functions utilizing system dynamics simulation and data mining is proposed to be incorporated into a safety culture management system. Additionally, a set of training and support programs are to be developed for the enhancement of some selected competence of the operating personnel in Korean NPPs. The safe operation of NPPs requires the typical safety culture characteristics of the high reliability organization (HRO). The culture of an organization is very complex to study and evaluate, but it is possible to examine the specific norms that figure out the culture for the safety of a system. This paper describes an integrated systems approach as an initiating plan to study the safety culture issue in Korean NPPs

  9. The relationship between occupational culture dimensions and reward preferences: A structural equation modelling approach

    Directory of Open Access Journals (Sweden)

    Mark Bussin


    Full Text Available Orientation: Reward has links to employee attraction and retention and as such has a role to play in managing talent. However, despite a range of research, there is still lack of clarity on employee preferences relating to reward. Research purpose: The purpose of the research was to recommend and appraise a theoretical model of the relationship between occupational culture dimensions and reward preferences of specific occupational groups in the South African context. Motivation for the study: The motivation for this study was to address the gap that exists with reward preferences and occupational culture with a view to identifying and gaining insight into individual preferences. Research design, approach and method: A structural equation modelling approach was adopted in exploring the proposed relationships. A South African Information, Communication, and Technology (ICT organisation served as the population, and a web-based survey assisted in gathering study data (n = 1362. Main findings: The findings provided support for the relationship between occupational culture dimensions and certain reward preferences. In particular, statistically significant results were obtained with the inclusion of the Environment, Team, and Time occupational culture dimensions as independent variables. Practical implications and value-add: The study provides workable input to organisations and reward professionals in the design of their reward strategies and programmes. Keywords: compensation; employee preferences; occupational culture; remuneration; reward preferences

  10. Transdermal delivery of diclofenac using water-in-oil microemulsion: formulation and mechanistic approach of drug skin permeation. (United States)

    Thakkar, Priyanka J; Madan, Parshotam; Lin, Senshang


    The objective of the present investigation was to enhance skin permeation of diclofenac using water-in-oil microemulsion and to elucidate its skin permeation mechanism. The w/o microemulsion formulations were selected based on constructed pseudoternary phase diagrams depending on water solubilization capacity and thermodynamic stability. These formulations were also subjected to physical characterization based on droplet size, viscosity, pH and conductivity. Permeation of diclofenac across rat skin using side-by-side permeation cells from selected w/o microemulsion formulations were evaluated and compared with control formulations. The selected w/o microemulsion formulations were thermodynamically stable, and incorporation of diclofenac sodium into microemulsion did not affect the phase behavior of system. All microemulsion formulations had very low viscosity (11-17 cps) and droplet size range of 30-160 nm. Microemulsion formulations exhibited statistically significant increase in diclofenac permeation compared to oily solution, aqueous solution and oil-Smix solution. Higher skin permeation of diclofenac was observed with low Smix concentration and smaller droplet size. Increase in diclofenac loading in aqueous phase decreased the partition of diclofenac. Diclofenac from the oil phase of microemulsion could directly partition into skin, while diclofenac from the aqueous droplets was carried through skin by carrier effect.

  11. [Beyond Weimar Culture--the significance of the Forman thesis for a cultural approach to the history of science]. (United States)

    Trischler, Helmuth; Carson, Cathryn; Kojevnikov, Alexei


    '"Forman thesis', published in 1971, argued for a historical linkage among the intellectual atmosphere of Weimar Germany, popular revolts against determinism and materialism, and the creation of the revolutionary new theory of quantum mechanics. Paul Forman's long essay on "Weimar Culture" has shaped research agendas in numerous fields, from the history and philosophy of physics to German history to the sociology of scientific knowledge. Despite its status as a classic and its transformative effect, Weimar Culture has always inspired as much critique as assent. In particular in the history of science, cohorts of students and two generations of scholars have debated the Forman thesis as a conceptual tool for linking scientific change with cultural processes. The Forman thesis raises critical questions for both the ongoing debates over cultural approaches to the history of science and the burgeoning newer scholarship on physics in and beyond Weimar Germany. Exploring these implications has been the aim of a transnational project of the three authors of this article which sheds some light on these debates and briefly introduces the following papers of this special issue devoted to Paul Forman and his seminal works in the history of science.

  12. The Dynamic Interplay among EFL Learners' Ambiguity Tolerance, Adaptability, Cultural Intelligence, Learning Approach, and Language Achievement (United States)

    Alahdadi, Shadi; Ghanizadeh, Afsaneh


    A key objective of education is to prepare individuals to be fully-functioning learners. This entails developing the cognitive, metacognitive, motivational, cultural, and emotional competencies. The present study aimed to examine the interrelationships among adaptability, tolerance of ambiguity, cultural intelligence, learning approach, and…

  13. Gender Approach at Physical Culture Lessons at the Second Stage of Basic High Education (United States)

    Vorotilkin?, Irina M.; Anokhina, Olga V.; Galitsyn, Sergey V.; Byankina, Larisa V.; Chiligin, Dmitriy V.


    Gender approach in education is a specific impact on the development of boys and girls by the set of factors of education and training process. The objective of this research is the reasoning of applying gender approach at physical culture lessons and creating comfortable environment taking into account the psychophysiological differences of the…

  14. Efficacy and toxicological studies of cremophor EL free alternative paclitaxel formulation. (United States)

    Utreja, Puneet; Jain, Subheet; Yadav, Subodh; Khandhuja, K L; Tiwary, A K


    In the present study, Cremophor EL free paclitaxel elastic liposomal formulation consisting of soya phosphatidylcholine and biosurfactant sodium deoxycholate was developed and optimized. The toxicological profile, antitumor efficacy and hemolytic toxicity of paclitaxel elastic liposomal formulation in comparison to Cremophor EL based marketed formulation were evaluated. Paclitaxel elastic liposomal formulations were prepared and characterized in vitro, ex-vivo and in vivo. Single dose toxicity study of paclitaxel elastic liposomal and marketed formulation was carried out in dose range of 10, 20, 40, 80, 120, 160 and 200 mg/kg. Cytotoxicity of developed formulation was evaluated using small cell lung cancer cell line (A549). Antitumor activity of developed formulation was compared with the marketed formulation using Cytoselect™ 96-well cell transformation assay. In vivo administration of paclitaxel elastic liposomal formulation into mice showed 6 fold increase in Maximum Tolerated Dose (MTD) in comparison to the marketed formulation. Similarly, LD50 (141.6 mg/kg) was also found to increase significantly than the marketed formulation (16.7 mg/kg). Result of antitumor assay revealed a high reduction of tumor density with paclitaxel elastic liposomal formulation. Reduction in hemolytic toxicity was also observed with paclitaxel elastic liposomal formulation in comparison to the marketed formulation. The carrier based approach for paclitaxel delivery demonstrated significant reduction in toxicity as compared to the Cremophor EL based marketed formulation following intra-peritoneal administration in mice model. The reduced toxicity and enhanced anti-cancer activity of elastic liposomal formulation strongly indicate its potential for safe and effective delivery of paclitaxel.

  15. Cultures Around the World: A Unique Approach to Youth Cultural Diversity Education

    Directory of Open Access Journals (Sweden)

    Justen O. Smith


    Full Text Available Increasingly diverse cultural trends have significant implications for the educational needs of American youth. Learning about and valuing diverse cultures will help prepare youth to become better citizens in an ever-changing society. Cultures Around the World was developed to meet the educational needs of youth in the area of cultural diversity. The Cultures Around the World program brings to life exciting cultures and customs from countries all over the world. Countries are presented in a unique format by teaching youth (ages 10 to 18 a specific country’s history, culture, food, music, dance, language, religion, and current issues. The Cultures Around the World program can be used by any youth educator. The program comes in a ready to use CD containing presentations, handicraft instructions, language guides, and resource guides for nine different countries (Armenia, Australia, Ecuador, Egypt, England, France, Ghana, Slovakia and Mexico.

  16. The Islamic Orient and the Development of Material Culture of Muscovy: Evaluation Methods

    Directory of Open Access Journals (Sweden)

    Belyaev Leonid A.


    Full Text Available The author discusses approaches to archaeological analysis of the Muslim contribution to the development of Muscovy, as well as the mere possibility of such analysis. So far, the studies focused on identifi cation of some interpenetrating elements of the material and artistic culture, which is necessary, but not quite suffi cient. New tasks must be formulated: to outline and characterize areas of intersection of various cultural streams; to identify forms and stages of such contacts; to understand ways for primary perception of impulses, which gave birth to distinctive national cultures in the Middle Ages and in the Modern era; to trace processing of such impulses further on; to try and understand whether there was a monocultural archaeological environment that existed in the past and belonged to the coexisting groups speaking different languages and belonging to different confessions.

  17. Enhanced Ungual Permeation of Terbinafine HCl Delivered Through Liposome-Loaded Nail Lacquer Formulation Optimized by QbD Approach. (United States)

    Shah, Viral H; Jobanputra, Amee


    The present investigation focused on developing, optimizing, and evaluating a novel liposome-loaded nail lacquer formulation for increasing the transungual permeation flux of terbinafine HCl for efficient treatment of onychomycosis. A three-factor, three-level, Box-Behnken design was employed for optimizing process and formulation parameters of liposomal formulation. Liposomes were formulated by thin film hydration technique followed by sonication. Drug to lipid ratio, sonication amplitude, and sonication time were screened as independent variables while particle size, PDI, entrapment efficiency, and zeta potential were selected as quality attributes for liposomal formulation. Multiple regression analysis was employed to construct a second-order quadratic polynomial equation and contour plots. Design space (overlay plot) was generated to optimize a liposomal system, with software-suggested levels of independent variables that could be transformed to desired responses. The optimized liposome formulation was characterized and dispersed in nail lacquer which was further evaluated for different parameters. Results depicted that the optimized terbinafine HCl-loaded liposome formulation exhibited particle size of 182 nm, PDI of 0.175, zeta potential of -26.8 mV, and entrapment efficiency of 80%. Transungual permeability flux of terbinafine HCl through liposome-dispersed nail lacquer formulation was observed to be significantly higher in comparison to nail lacquer with a permeation enhancer. The developed formulation was also observed to be as efficient as pure drug dispersion in its antifungal activity. Thus, it was concluded that the developed formulation can serve as an efficient tool for enhancing the permeability of terbinafine HCl across human nail plate thereby improving its therapeutic efficiency.

  18. Fundamental theories of waves and particles formulated without classical mass (United States)

    Fry, J. L.; Musielak, Z. E.


    Quantum and classical mechanics are two conceptually and mathematically different theories of physics, and yet they do use the same concept of classical mass that was originally introduced by Newton in his formulation of the laws of dynamics. In this paper, physical consequences of using the classical mass by both theories are explored, and a novel approach that allows formulating fundamental (Galilean invariant) theories of waves and particles without formally introducing the classical mass is presented. In this new formulation, the theories depend only on one common parameter called 'wave mass', which is deduced from experiments for selected elementary particles and for the classical mass of one kilogram. It is shown that quantum theory with the wave mass is independent of the Planck constant and that higher accuracy of performing calculations can be attained by such theory. Natural units in connection with the presented approach are also discussed and justification beyond dimensional analysis is given for the particular choice of such units.

  19. A Framework Approach to Evaluate Cross-Cultural Adaptation of Public Engagement Strategies for Radioactive Waste Management - 13430

    International Nuclear Information System (INIS)

    Hermann, Laura


    The complex interplay of politics, economics and culture undermines attempts to define universal best practices for public engagement in the management of nuclear materials. In the international context, communicators must rely on careful adaptation and creative execution to make standard communication techniques succeed in their local communities. Nuclear professionals need an approach to assess and adapt culturally specific public engagement strategies to meet the demands of their particular political, economic and social structures. Using participant interviews and public sources, the Potomac Communications Group reviewed country-specific examples of nuclear-related communication efforts to provide insight into a proposed approach. The review considered a spectrum of cultural dimensions related to diversity, authority, conformity, proximity and time. Comparisons help to identify cross-cultural influences of various public engagement tactics and to inform a framework for communicators. While not prescriptive in its application, the framework offers a way for communicators to assess the salience of outreach tactics in specific situations. The approach can guide communicators to evaluate and tailor engagement strategies to achieve localized public outreach goals. (authors)

  20. A Framework Approach to Evaluate Cross-Cultural Adaptation of Public Engagement Strategies for Radioactive Waste Management - 13430

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, Laura [Potomac Communications Group, 1133 20th St NW Washington DC 20035 (United States)


    The complex interplay of politics, economics and culture undermines attempts to define universal best practices for public engagement in the management of nuclear materials. In the international context, communicators must rely on careful adaptation and creative execution to make standard communication techniques succeed in their local communities. Nuclear professionals need an approach to assess and adapt culturally specific public engagement strategies to meet the demands of their particular political, economic and social structures. Using participant interviews and public sources, the Potomac Communications Group reviewed country-specific examples of nuclear-related communication efforts to provide insight into a proposed approach. The review considered a spectrum of cultural dimensions related to diversity, authority, conformity, proximity and time. Comparisons help to identify cross-cultural influences of various public engagement tactics and to inform a framework for communicators. While not prescriptive in its application, the framework offers a way for communicators to assess the salience of outreach tactics in specific situations. The approach can guide communicators to evaluate and tailor engagement strategies to achieve localized public outreach goals. (authors)

  1. An experimental approach towards the development of an in vitro cortical-thalamic co-culture model. (United States)

    Kanagasabapathi, Thirukumaran T; Massobrio, Paolo; Tedesco, Mariateresa; Martinoia, Sergio; Wadman, Wytse J; Decré, Michel M J


    In this paper, we propose an experimental approach to develop an in vitro dissociated cortical-thalamic co-culture model using a dual compartment neurofluidic device. The device has two compartments separated by 10 μm wide and 3 μm high microchannels. The microchannels provide a physical isolation of neurons allowing only neurites to grow between the compartments. Long-term viable co-culture was maintained in the compartmented device, neurite growth through the microchannels was verified using immunofluorescence staining, and electrophysiological recordings from the co-culture system was investigated. Preliminary analysis of spontaneous activities from the co-culture shows a distinctively different firing pattern associated with cultures of individual cell types and further analysis is proposed for a deeper understanding of the dynamics involved in the network connectivity in such a co-culture system.

  2. [Traditional and modern approaches to culture of preimplantation mammalian embryos in vitro]. (United States)

    Brusentsev, E Iu; Igonina, T N; Amstislavskiĭ, S Ia


    This review covers the basic principles and methods of in vitro culture of preimplantation mammalian embryos. The features of in vitro development of embryos of various species of animals with allowance for the composition of nutrient media are described, with special attention paid to those species that have traditionally been consideredas laboratory (i.e., mice, rats, and hamsters). The effects of suboptimal culturing conditions of preimplantation embryos on the formation of the phenotype of individuals developed from these embryos are discussed. New approaches to optimize the conditions of the development of preimplantation mammalian embryos in vitro are analyzed.

  3. Using non-feature films to teach diversity, cultural competence, and the DSM-IV-TR outline for cultural formulation. (United States)

    Lim, Russell F; Diamond, Ronald J; Chang, Jacquelyn B; Primm, Annelle B; Lu, Francis G


    Feature films have been used for teaching in psychiatry for many years to demonstrate diagnoses, but the use of documentary and instructional films in resident and staff cultural competence training have not been extensively written about in the medical and psychological literature. This article will describe the films that have been used by the authors and suggest methods for their use in cultural competence and diversity training. A literature search was done using MEDLINE and PsychINFO and the authors were asked to describe their teaching methods. One article was found detailing the use of videotapes as a stimulus but not for cultural competence education, and two articles were found documenting the use of The Color of Fear as a stimulus for the discussion of racism. However, many educators use these films all across the country for the purpose of opening discussion about racism. Documentary, instructional, and public service announcements can be useful in teaching culturally competent assessment and treatment.

  4. Does National Culture Impact Capital Budgeting Systems?


    Peter J. Graham; Milind Sathye


    We examine how national culture impacts organisational selection of capital budgeting systems to develop our understanding of what influence a holistic formulation of national culture has on capital budgeting systems. Such an understanding is important as it would not only provide a clearer link between national culture and capital budgeting systems and advance extant literature but would also help multinational firms that have business relationships with Indonesian firms in suita...

  5. The Scourges of the South? Essays on "The Sickly South" in History, Literature, and Popular Culture

    DEFF Research Database (Denmark)

    “sickly” culture as not so much southern “problems”, but, rather, southern opportunities, or else, springboards to yet another of the South’s cultural revitalizations, “health”. As Thomas Ærvold Bjerre and Beata Zawadka note in their introduction, the so-called “Healthy South” has never been an easy topic...... for scholars dealing with the region. One reason for this is that researchers have been taught to approach so formulated a topic no further than to the point when it turns out it is a contradiction in terms, and, indeed, there is much in southern history and the present situation that justifies...

  6. Novel and unexpected bacterial diversity in an arsenic-rich ecosystem revealed by culture-dependent approaches

    Directory of Open Access Journals (Sweden)

    Delavat François


    Full Text Available Abstract Background Acid Mine Drainages (AMDs are extreme environments characterized by very acid conditions and heavy metal contaminations. In these ecosystems, the bacterial diversity is considered to be low. Previous culture-independent approaches performed in the AMD of Carnoulès (France confirmed this low species richness. However, very little is known about the cultured bacteria in this ecosystem. The aims of the study were firstly to apply novel culture methods in order to access to the largest cultured bacterial diversity, and secondly to better define the robustness of the community for 3 important functions: As(III oxidation, cellulose degradation and cobalamine biosynthesis. Results Despite the oligotrophic and acidic conditions found in AMDs, the newly designed media covered a large range of nutrient concentrations and a pH range from 3.5 to 9.8, in order to target also non-acidophilic bacteria. These approaches generated 49 isolates representing 19 genera belonging to 4 different phyla. Importantly, overall diversity gained 16 extra genera never detected in Carnoulès. Among the 19 genera, 3 were previously uncultured, one of them being novel in databases. This strategy increased the overall diversity in the Carnoulès sediment by 70% when compared with previous culture-independent approaches, as specific phylogenetic groups (e.g. the subclass Actinobacteridae or the order Rhizobiales were only detected by culture. Cobalamin auxotrophy, cellulose degradation and As(III-oxidation are 3 crucial functions in this ecosystem, and a previous meta- and proteo-genomic work attributed each function to only one taxon. Here, we demonstrate that other members of this community can also assume these functions, thus increasing the overall community robustness. Conclusions This work highlights that bacterial diversity in AMDs is much higher than previously envisaged, thus pointing out that the AMD system is functionally more robust than expected

  7. Charge-field formulation of quantum electrodynamics (QEMED)

    International Nuclear Information System (INIS)

    Leiter, D.


    By expressing classical electron theory in terms of 'charge-field' functional structures, it is shown that a finite formulation of the classical electrodynamics of point charges emerges in a simple and elegant fashion. This is used to construct a 'charge-field' quantum electrodynamic theory. It is found that interacting photon states are generated as a secondary manifestation of electron-positron quantization, and do not require the usual 'free' canonical quantization scheme. The possibility is discussed that this approach may lead to a better formulation of quantum electrodynamics in the Heisenberg picture and suggests a crucial experimental test to distinguish this new 'charge-field' quantum electrodynamics 'QEMED' from the standard QED formulation. Specifically QEMED predicts that the 'Einstein principle of separability' should be found to be valid for correlated photon polarization measurements, in which the polarizers are changed more rapidly than a characteristic photon travel time. Such an experiment (Aspect 1976) can distinguish between QEMED and QED in a complete and clear-cut fashion. (U.K.)

  8. Environmental Remediation Full-Scale Implementation: Back to Simple Microbial Massive Culture Approaches

    Directory of Open Access Journals (Sweden)

    Agung Syakti


    Full Text Available Using bioaugmentation and biostimulation approach for contaminated soil bioremediation were investigated and implemented on field scale. We combine those approaches by culturing massively the petrophilic indigenous microorganisms from chronically contaminated soil enriched by mixed manure. Through these methods, bioremediation performance revealed promising results in removing the petroleum hydrocarbons comparatively using metabolite by product such as biosurfactant, specific enzymes and other extra-cellular product which are considered as a difficult task and will impact on cost increase.

  9. Chinese culture approached through touch

    DEFF Research Database (Denmark)

    Wang, Li; Champion, Erik


    Can recent technology help bridge cultures through playful interaction appropriate to traditional tacit means of acquiring knowledge? In order to help answer this question, we designed four Adobe Flash-based based game prototypes and evaluated them via a touch-screen PC. The goal was to offer non......, fun, and cultural authenticity. While this form of tangible computing proved engaging, it raises technical issues of how to convey appropriately the interactive elements without the help of the evaluator, and how to evaluate user satisfaction. We also briefly discuss more embodied and spatial......Chinese participants a playful way of experiencing aspects of traditional Chinese culture. The four single-player games were based on the four arts of China (music, calligraphy, painting and the game of Go!). In the evaluation we asked non-Chinese and the Chinese participants to evaluate the games in terms of learning...

  10. Langevin formulation of quantum dynamics

    International Nuclear Information System (INIS)

    Roncadelli, M.


    We first show that nonrelativistic quantum mechanics formulated at imaginary-(h/2 π) can formally be viewed as the Fokker-Planck description of a frictionless brownian motion, which occurs (in general) in an absorbing medium. We next offer a new formulation of quantum mechanics, which is basically the Langevin treatment of this brownian motion. Explicitly, we derive a noise-average representation for the transition probability W(X'',t''|X',t'), in terms of the solutions to a Langevin equation with a Gaussian white-noise. Upon analytic continuation back to real-(h/2 π),W(X'',t''|X',t') becomes the propagator of the original Schroedinger equation. Our approach allows for a straightforward application to quantum dynamical problems of the mathematical techniques of classical stochastic processes. Moreover, computer simulations of quantum mechanical systems can be carried out by using numerical programs based on the Langevin dynamics. (author). 19 refs, 1 tab

  11. Cultural visions of technology. Paradoxes of panoptic and interactive perspectives and methods

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard


    The essential premise of the human-centered technology paradigm was clearly formulated by Howard Rosenbrock in the 1970s: technology should enrich rather than impoverish people’s work and life conditions. The increasing influence of technology in modern societies has been seen by some as offering...... great promise for the future, but by others as creating the electronic surveillance and/or manipulation of human genes, minds and beliefs. This paper approaches technological worlds as cultural visions in order to discuss and reflect the paradoxical process of viewing technology as part of a hope...

  12. Using Social Scientific Criteria to Evaluate Cultural Theories: Encoding/Decoding Evaluated


    Evan L. Kropp


    This article transcends the issue of conflicting theoretical schools of thought to formulate a method of social scientific style theory evaluation for cultural studies. It is suggested that positivist social scientific models of theory critique can be used to assess cultural models of communication to determine if they should be classified as theories. A set of evaluation criteria is formulated as a guide and applied to Stuart Hall’s Encoding/Decoding to determine if it is a theory. Conclusio...

  13. Formulation of cheaper artificial feeds for shrimp culture: preliminary biochemical, physical and biological evaluation

    Digital Repository Service at National Institute of Oceanography (India)

    Goswami, U.; Goswami, S.C.

    flour, mangroveleaves, and wheat flour, were analysed biochemically for their nutritive value. The formulated diet is in a dry pellet form. It was assessed experimentally for its physical stability and subsequently fed to various size groups of a...

  14. Cultural distance between parents' and children's creativity: A within-country approach in Taiwan. (United States)

    Chang, Jen-Ho; Su, Jenny C; Chen, Hsueh-Chih


    The present study adopted a within-country approach to investigate the relation of cultural distance to general creativity and math creativity in Taiwan. First, we conducted a pilot study of 201 young adolescents with parents from one of the 3 largest subethnic groups in Taiwan, namely Min-nan Taiwanese, Ha-kka Taiwanese, and Outside-Province Taiwanese. The results revealed that young Taiwanese adolescents perceived the cultural distance between Min-nan Taiwanese and Outside-Province Taiwanese as larger than the cultural distance between the other subethnic groups. The main study revealed that 610 young adolescents from large cultural distance families (i.e., those comprising 1 Min-nan Taiwanese parent and 1 Outside-Province Taiwanese parent) outperformed those from small cultural distance families (i.e., those comprising 2 Min-nan Taiwanese parents, and those comprising 1 Min-nan Taiwanese parent and 1 Ha-kka Taiwanese parent) on both general creativity and math creativity. This pattern remained even after controlling for family socioeconomic status, parents' education level, and adolescents' school mathematical performance. Implications and limitations are discussed. (c) 2015 APA, all rights reserved).

  15. Drug Solubility in Fatty Acids as a Formulation Design Approach for Lipid-Based Formulations: A Technical Note. (United States)

    Lee, Yung-Chi; Dalton, Chad; Regler, Brian; Harris, David


    Lipid-based drug delivery systems have been intensively investigated as a means of delivering poorly water-soluble drugs. Upon ingestion, the lipases in the gastrointestinal tract digest lipid ingredients, mainly triglycerides, within the formulation into monoglycerides and fatty acids. While numerous studies have addressed the solubility of drugs in triglycerides, comparatively few publications have addressed the solubility of drugs in fatty acids, which are the end product of digestion and responsible for the solubility of drug within mixed micelles. The objective of this investigation was to explore the solubility of a poorly water-soluble drug in fatty acids and raise the awareness of the importance of drug solubility in fatty acids. The model API (active pharmaceutical ingredient), a weak acid, is considered a BCS II compound with an aqueous solubility of 0.02 μg/mL and predicted partition coefficient >7. The solubility of API ranged from 120 mg/mL to over 1 g/mL in fatty acids with chain lengths across the range C18 to C6. Hydrogen bonding was found to be the main driver of the solubilization of API in fatty acids. The solubility of API was significantly reduced by water uptake in caprylic acid but not in oleic acid. This report demonstrates that solubility data generated in fatty acids can provide an indication of the solubility of the drug after lipid digestion. This report also highlights the importance of measuring the solubility of drugs in fatty acids in the course of lipid formulation development.

  16. A Spreadsheet-Based, Matrix Formulation Linear Programming Lesson

    DEFF Research Database (Denmark)

    Harrod, Steven


    The article focuses on the spreadsheet-based, matrix formulation linear programming lesson. According to the article, it makes a higher level of theoretical mathematics approachable by a wide spectrum of students wherein many may not be decision sciences or quantitative methods majors. Moreover...

  17. Modular Approach to Designing Computer Cultural Systems: Culture as a Thermodynamic Machine

    Directory of Open Access Journals (Sweden)

    Leland Gilsen


    Full Text Available Culture is a complex non-linear system. In order to design computer simulations of cultural systems, it is necessary to break the system down into sub-systems. Human culture is modular. It consists of sets of people that belong to economic units. Access to, and control over matter, energy and information is postulated as the key to development of cultural simulations. Because resources in the real world are patchy, access to and control over resources is expressed in two related arenas: economics (direct control and politics (non-direct control. The best way to create models for cultural ecology/economics lies in an energy-information-economic paradigm based on general systems theory and an understanding of the "thermodynamics" of ecology, or culture as a thermodynamic machine.

  18. The Risk of Hyper-Culture: How to Avoid It and Work With Real Organizational Culture

    International Nuclear Information System (INIS)

    Alvesson, M.


    The talk addresses the issue of work with organizational culture often circling around nicely formulated, vague and idealistic words — hyper culture. These look good on power point presentations and in policy documents. They seldom work well in practical use. But senior managers, consultants, staff people and educators like the nice-sounding. It is good for status and self-esteem. And we all like what is pedagogical, astetic and reassuring. The talk addresses the phenomenon of hyper culture. And points at ways to avoid these and work with organizational practices in relation to culture. The talk draws on the presenter’s book THE TRIUMPH OF EMPTINESS. Oxford University Press. (author)

  19. Cultural contact over the Strait of Gibraltar during the Middle Palaeolithic? Evaluating the visibility of cultural exchange

    Directory of Open Access Journals (Sweden)



    Full Text Available Possible contacts between hunter-gatherers of Northern Africa and Europe via the Strait of Gibraltar during the Pleistocene are still object to discussions. In the absence of significant fossil remains, debates are mainly based on similarities and differences of singular aspects of material culture. However, a theoretical framework for these discussions was lacking. The first aim of this study thus has been the development of a theoretical base. We therein included Maslow´s pyramid of basic needs. The idea of our approach is that the presence or absence of so-called cultural tracers identify either contact or disparity. A large database on archaeological sites of Morocco and Southern Iberia dating between 160 ka and 40 ka years ago has been compiled, containing information about lithic technology and typology, lithic raw material acquisition, subsistence patterns and symbolic behaviour. We formulated three potential contact scenarios between the two regions. The presence and/or absence of so-called cultural tracers within the data set, that covered all levels of Maslow´s pyramid, led us to conclude that – based on the present archaeological and anthropological data - no contact took place between Iberian and North African populations across the Strait of Gibraltar in the given time frame.

  20. How reliable are case formulations? A systematic literature review. (United States)

    Flinn, Lucinda; Braham, Louise; das Nair, Roshan


    This systematic literature review investigated the inter-rater and test-retest reliability of case formulations. We considered the reliability of case formulations across a range of theoretical modalities and the general quality of the primary research studies. A systematic search of five electronic databases was conducted in addition to reference list trawling to find studies that assessed the reliability of case formulation. This yielded 18 studies for review. A methodological quality assessment tool was developed to assess the quality of studies, which informed interpretation of the findings. Results indicated inter-rater reliability mainly ranging from slight (.1-.4) to substantial (.81-1.0). Some studies highlighted that training and increased experience led to higher levels of agreement. In general, psychodynamic formulations appeared to generate somewhat increased levels of reliability than cognitive or behavioural formulations; however, these studies also included methods that may have served to inflate reliability, for example, pooling the scores of judges. Only one study investigated the test-retest reliability of case formulations yielding support for the stability of formulations over a 3-month period. Reliability of case formulations is varied across a range of theoretical modalities, but can be improved; however, further research is required to strengthen our conclusions. Clinical implications: The findings from the review evidence some support for case formulation being congruent with the scientist-practitioner approach. The reliability of case formulation is likely to be improved through training and clinical experience. Limitations: The broad inclusion criteria may have introduced heterogeneity into the sample, which may have affected the results. Studies reviewed were limited to peer-reviewed journal articles written in the English language, which may represent a source of publication and selection bias. © 2014 The British Psychological Society.

  1. Approaching German Culture: A Tentative Analysis (United States)

    Tinsley, Royal; Woloshin, David


    A comparative analysis of the five universal problems of cultural orientation: 1) human nature, 2) social relations, 3) man and nature, 4) time, 5) space, as they are reflected in German and American culture. (PP)

  2. Formulation of diclofenac for dermal delivery. (United States)

    Goh, Choon Fu; Lane, Majella E


    Diclofenac (DF) was first synthesized in the 1960's and is currently available as ophthalmic, oral, parenteral, rectal and skin preparations. This review focuses on the administration of DF to the skin. As a member of the non-steroidal anti-inflammatory (NSAID) group of drugs the primary indications of DF are for the management of inflammation and pain but it is also used to treat actinic keratosis. The specific aims of this paper are to: (i) provide an overview of the pharmacokinetics and metabolism of DF following oral and topical administration; (ii) examine critically the various formulation approaches which have been investigated to enhance dermal delivery of DF; and (iii) identify new formulation strategies for enhanced DF skin penetration. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. Superspace formulation in a three-algebra approach to D=3, N=4, 5 superconformal Chern-Simons matter theories

    International Nuclear Information System (INIS)

    Chen Famin; Wu Yongshi


    We present a superspace formulation of the D=3, N=4, 5 superconformal Chern-Simons Matter theories, with matter supermultiplets valued in a symplectic 3-algebra. We first construct an N=1 superconformal action and then generalize a method used by Gaitto and Witten to enhance the supersymmetry from N=1 to N=5. By decomposing the N=5 supermultiplets and the symplectic 3-algebra properly and proposing a new superpotential term, we construct the N=4 superconformal Chern-Simons matter theories in terms of two sets of generators of a (quaternion) symplectic 3-algebra. The N=4 theories can also be derived by requiring that the supersymmetry transformations are closed on-shell. The relationship between the 3-algebras, Lie superalgebras, Lie algebras, and embedding tensors (proposed in [E. A. Bergshoeff, O. Hohm, D. Roest, H. Samtleben, and E. Sezgin, J. High Energy Phys. 09 (2008) 101.]) is also clarified. The general N=4, 5 superconformal Chern-Simons matter theories in terms of ordinary Lie algebras can be re-derived in our 3-algebra approach. All known N=4, 5 superconformal Chern-Simons matter theories can be recovered in the present superspace formulation for super-Lie algebra realization of symplectic 3-algebras.

  4. A quality by design approach on polymeric nanocarrier delivery of gefitinib: formulation, in vitro, and in vivo characterization

    Directory of Open Access Journals (Sweden)

    Kola Srinivas NS


    Full Text Available Navya Sree Kola Srinivas,1 Ruchi Verma,2 Girish Pai Kulyadi,1 Lalit Kumar1 1Department of Pharmaceutics, 2Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India Abstract: Gefitinib is an anticancer agent which acts by inhibiting epidermal growth factor receptor tyrosine kinase receptors. The aim of the present study was to prepare gefitinib nanosuspension. Gefitinib was encapsulated in Eudragit® RL100 and then dispersed in stabilizer solution, polyvinyl alcohol, and polyvinylpyrrolidone K30. Nanosuspension was prepared by using homogenization and ultrasonication techniques. The quality by design approach was also used in the study to understand the effect of critical material attributes (CMAs and critical processing parameters (CPPs on critical quality attributes and to improve the quality and safety of formulation. To study the effect of CMAs and CPPs, 23 full factorial design was applied. The particle size, polydispersity index, and zeta potential of the optimized solution were 248.20 nm, 0.391, and -5.62 mV, respectively. Drug content of the optimized nanoformulation was found to be 87.74%±1.19%. Atomic force microscopy studies of the optimized formulation confirmed that the prepared nanoparticles are smooth and spherical in nature. In vitro cytotoxicity studies of the nanosuspension on Vero cell line revealed that the formulation is nontoxic. The gefitinib nanosuspension released 60.03%±4.09% drug over a period of 84 h, whereas standard drug dispersion released only 10.39%±3.37% drug in the same duration. From the pharmacokinetic studies, half-life, Cmax, and Tmax of the drug of an optimized nanosuspension were found to be 8.65±1.99 h, 46,211.04±5,805.97 ng/mL, and 6.67±1.77 h, respectively. A 1.812-fold increase in relative bioavailability of nanosuspension was found, which confirmed that the present formulation is suitable to enhance the oral bioavailability

  5. Protecting the fast breeders: Problem formulation and effects analysis

    International Nuclear Information System (INIS)

    Oughton, D.H.


    Recent debates on protection of the environment from ionising radiation have reached reasonable agreement over the ethical and philosophical basis of environmental protection and a recognition that a practical system of protection will need to support (at a minimum) the principles of sustainable development, biodiversity, and conservation. However, there is still some controversy over the use of dose assessment tools within risk evaluation and management. The paper uses the case of the Dounreay 'radioactive rabbits' to discuss the advantages and limitations of proposed systems, focusing primarily on the interaction between ecological risk assessment (ERA) and the reference flora and fauna approach. It concludes that the reference approach is a valuable tool for the analysis of environmental effects, but that there is a problem if it becomes the driving force of the protection framework. In particular, there is a need for a clearer focus on non-technical issues within the problem formulation stage of ERA, particularly the social, ethical, political and economic issues, and there should be a strong commitment to stakeholder involvement at this stage. The problem formulation stage should identify the relevant assessment tools; the assessment tool should dictate neither the problem formulation nor the risk management. (author)

  6. Performed Culture: An Approach to East Asian Language Pedagogy. Pathways to Advanced Skills Series, Volume 11 (United States)

    Christensen, Matthew; Warnick, Paul


    This book is a general introduction to the performed culture approach, which trains students how to express themselves in a way that native speakers of the target culture feel appropriate in given situations. Target readership includes Chinese, Japanese, and Korean language teachers and graduate students. Chapters of this book include: (1)…

  7. The Influence of Linguistics upon the Formation of the Culture-Historical Approach in Archaeology

    Directory of Open Access Journals (Sweden)

    Zorica Kuzmanović


    Full Text Available Through the critical research into the history of archaeology, the paper aims to explore the influence of linguistics and, more generally, the role of language in modern societies, upon the formation of the culture-historical approach in the discipline, focusing upon the situation in the Serbian archaeology. In doing so, the author follows the series of the similar critical historical accounts of the history of archaeology, pointing to the conceptual burden carried along with the culture-historical practice of attributing artefacts according to their cultural affiliation, automatically making inferences about the cultural/ ethnic identity of the people who used them. The need to analyse the relationship between linguistics and archaeology at the time of formation of the discipline originates from the standpoint that, even if we do not advocate the complete rejection of the culture-historical tradition (still impossible, however, it is nevertheless necessary to understand the ways in which certain meanings were formed, implicit to the archaeological concept of culture. In this way, it becomes possible to avoid the interpretive mistakes inherent to the conceptual burden of the discipline.

  8. Meaningful Learning in the Teaching of Culture: The Project Based Learning Approach (United States)

    Kean, Ang Chooi; Kwe, Ngu Moi


    This paper reports on a collaborative effort taken by a team of three teacher educators in using the Project Based Learning (PBL) approach in the teaching of Japanese culture with the aim to investigate the presence of actual "meaningful learning" among 15 students of a 12-Week Preparatory Japanese Language course under a teacher…

  9. SfM for Orthophoto to Generation: A Winning Approach for Cultural Heritage Knowledge

    Directory of Open Access Journals (Sweden)

    F. Chiabrando


    Full Text Available 3D detailed models derived from digital survey techniques have increasingly developed and focused in many field of application. The high detailed content and accuracy of such models make them so attractive and usable for large sets of purposes in Cultural Heritage. The present paper focuses on one of the main techniques used nowadays for Cultural Heritage survey and documentation: the image matching approach or Structure from Motion (SfM technique. According to the low cost nature and the rich content of derivable information, these techniques are extremely strategic in poor available resources sectors such as Cultural Heritage documentation. After an overview of the employed algorithms and used approaches of SfM computer vision based techniques, the paper is focused in a critical analysis of the strategy used by two common employed software: the commercial suite Agisoft Photoscan and the open source tool MicMac realized by IGN France. The experimental section is focused on the description of applied tests (from RPAS data to terrestrial acquisitions, purposed to compare different solutions in various featured study cases. Finally, the accuracy assessment of the achieved products is compared and analyzed according to the strategy employed by the studied software.

  10. Quality by Design (QbD) approach to optimize the formulation of a bilayer combination tablet (Telmiduo®) manufactured via high shear wet granulation. (United States)

    Lee, Ah Ram; Kwon, Seok Young; Choi, Du Hyung; Park, Eun Seok


    A bilayer tablet, which consisted of telmisartan and amlodipine besylate, was formulated based on a Quality by Design (QbD) approach. The control and response factors were determined based on primary knowledge and the target values of the control tablet (Twynsta ® ). A D-optimal mixture design was used to obtain the optimal formulations in terms of D-mannitol, crospovidone, and MCC for the telmisartan layer, and CCM-Na, PVP K25, and Prosolv for the amlodipine layer. The quantitative effects of the different formulation factors on the response factors were accurately predicted using the equations of best fit and a strong linearity was observed between the predicted and actual values of the response factors. The optimized bilayer tablet was obtained using a numeric optimization technique and was characterized compared with a control (Twynsta ® ) by using various physical evaluations and in vivo pharmacokinetic parameters. The physical stability of Telmiduo ® was greater than that of Twynsta ® owing to the improvement of formulation factors. The in vivo pharmacokinetic parameters suggested that Telmiduo ® might have pharmaceutical equivalence and bioequivalence with Twynsta ® . Therefore, the bilayer tablet that consisted of telmisartan and amlodipine besylate could be produced using a more economical and simpler method than that used to produce Twynsta ® . Moreover, the suitability of QbD for effective product development in the pharmaceutical industry was shown. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Within-culture variations of uniqueness: towards an integrative approach based on social status, gender, life contexts, and interpersonal comparison. (United States)

    Causse, Elsa; Félonneau, Marie-Line


    Research on uniqueness is widely focused on cross-cultural comparisons and tends to postulate a certain form of within-culture homogeneity. Taking the opposite course of this classic posture, we aimed at testing an integrative approach enabling the study of within-culture variations of uniqueness. This approach considered different sources of variation: social status, gender, life contexts, and interpersonal comparison. Four hundred seventy-nine participants completed a measure based on descriptions of "self" and "other." Results showed important variations of uniqueness. An interaction between social status and life contexts revealed the expression of uniqueness in the low-status group. This study highlights the complexity of uniqueness that appears to be related to both cultural ideology and social hierarchy.

  12. Recommendations of the Oligonucleotide Safety Working Group's Formulated Oligonucleotide Subcommittee for the Safety Assessment of Formulated Oligonucleotide-Based Therapeutics. (United States)

    Marlowe, Jennifer L; Akopian, Violetta; Karmali, Priya; Kornbrust, Douglas; Lockridge, Jennifer; Semple, Sean


    The use of lipid formulations has greatly improved the ability to effectively deliver oligonucleotides and has been instrumental in the rapid expansion of therapeutic development programs using oligonucleotide drugs. However, the development of such complex multicomponent therapeutics requires the implementation of unique, scientifically sound approaches to the nonclinical development of these drugs, based upon a hybrid of knowledge and experiences drawn from small molecule, protein, and oligonucleotide therapeutic drug development. The relative paucity of directly applicable regulatory guidance documents for oligonucleotide therapeutics in general has resulted in the generation of multiple white papers from oligonucleotide drug development experts and members of the Oligonucleotide Safety Working Group (OSWG). The members of the Formulated Oligonucleotide Subcommittee of the OSWG have utilized their collective experience working with a variety of formulations and their associated oligonucleotide payloads, as well as their insights into regulatory considerations and expectations, to generate a series of consensus recommendations for the pharmacokinetic characterization and nonclinical safety assessment of this unique class of therapeutics. It should be noted that the focus of Subcommittee discussions was on lipid nanoparticle and other types of particulate formulations of therapeutic oligonucleotides and not on conjugates or other types of modifications of oligonucleotide structure intended to facilitate delivery.

  13. Citizenship culture: psychosocial approach to the law in the context of a Rio de Janeiro slum

    Directory of Open Access Journals (Sweden)

    Georgie Alexánder Echeverri


    Full Text Available In the first part of this paper, we approach the citizenship culture as it was developed in Colombia by the former mayor of Bogotá, Antanas Mockus, taking into account both the conceptual structure and the methodological principles of implementation, namely, the internalization of the rule and the creation of communication strategies aimed at achieving willingly cooperation. After making a psychosocial approach of the citizenship culture in the light of the theory of the social representations, we present the results of a prototypical analysis based on free association data from a sample of 156 teenagers who live at Mangueira slum, in Rio de Janeiro, exercise that enabled us to make a socio-cultural and political reading from the fulfillment or failure of the law. Finally, as an educational proposal, we hand in the results of a participatory action research —Aventureiros—, a program of education for citizenship focused on children, based on the very Colombian methodological principles of the citizenship culture and adapted to the Rio de Janeiro favela environment.

  14. Perceived cultural importance and actual self-importance of values in cultural identification. (United States)

    Wan, Ching; Chiu, Chi-yue; Tam, Kim-pong; Lee, Sau-lai; Lau, Ivy Yee-man; Peng, Siqing


    Cross-cultural psychologists assume that core cultural values define to a large extent what a culture is. Typically, core values are identified through an actual self-importance approach, in which core values are those that members of the culture as a group strongly endorse. In this article, the authors propose a perceived cultural importance approach to identifying core values, in which core values are values that members of the culture as a group generally believe to be important in the culture. In 5 studies, the authors examine the utility of the perceived cultural importance approach. Results consistently showed that, compared with values of high actual self-importance, values of high perceived cultural importance play a more important role in cultural identification. These findings have important implications for conceptualizing and measuring cultures. ((c) 2007 APA, all rights reserved).

  15. Partnership for Diversity: A Multidisciplinary Approach to Nurturing Cultural Competence at an Emerging Medical School. (United States)

    Swanberg, Stephanie M; Abuelroos, Dena; Dabaja, Emman; Jurva, Stephanie; Martin, Kimberly; McCarron, Joshua; Reed-Hendon, Caryn; Yeow, Raymond Y; Harriott, Melphine M


    Fostering cultural competence in higher education institutions is essential, particularly in training future health care workers to care for diverse populations. The opportunity to explore techniques to address diversity and cultural competence at a new medical school was undertaken by a multidisciplinary team of librarians, faculty, staff, and medical students. From 2011 to 2015, the team sponsored a voluntary programming series to promote cultural competence and raise awareness of health care disparities for the medical school. Thirteen events were hosted with 562 participants across all. This approach to diversity proved effective and could be adapted in any higher education setting.

  16. Principles of ration formulation for ruminants

    International Nuclear Information System (INIS)

    Jayasuriya, M.C.N.


    Feeding standards as practiced in developed countries could be misleading when non-conventional feed resources are used in formulating rations for ruminant livestock in developing countries. They tend to reject the poor quality feeds that are available in vast quantities. The non-availability of good quality forage throughout the year and the need to optimise the efficiency of utilisation of locally available feed resources have lead to the application of basic nutritional principles when considering ration formulation. The alternative approach to the use of feeding standards would be to ensure that the production system matches the available resources. The development of feed supplementation strategies based on locally available feed resources require the understanding of the relative roles and nutrient needs of the two-compartment system represented by the micro-organisms in the rumen and the host animal. (author)

  17. Hong Kong Chinese daughters' intergenerational caregiving obligations: a cultural model approach. (United States)

    Holroyd, E


    This paper, based on a study carried out in Hong Kong, outlines the caregiving obligations of Hong Kong Chinese daughters towards their frail elderly parents. A cultural model approach drawn from cognitive anthropology is taken to focus on how Chinese caregiving daughters develop a sense of what is right and emotionally fulfilling and acquire the motivation to care for their parents. An ethnographic approach was used in the study and techniques included guided and open-ended interviews and non-participatory observations. A total of 20 co-residential caregiving daughters were interviewed in their homes on average twice over the course of one year. All interviews were conducted in Cantonese. Although the sample was small, daughters' accounts are structured by reference to cultural models and this structure provides the common basis for generalisability of results. Concepts of Confucian antecedents, reciprocity and personhood and other modern ideas of filial duty are explored. Conclusions are drawn about the shifting rights and obligations of Chinese caregiving daughters within the contemporary urban realities of Hong Kong. The findings of this study have relevance for the development of welfare policy for older Chinese persons and the chronically ill, and to all services involving women. The findings will also serve to inform family caregiver education programs.

  18. Cultural Understanding Through Cross-Cultural Analysis. (United States)

    Briere, Jean-Francois


    A college course used an explicit intercultural approach and collective research activities to compare French and American cultures and to examine the reasons for cultural attitudes and culture conflict. Class assignments dealt with contrastive analyses of American and French institutions like advertising, cinema, feminism, etc. (MSE)

  19. Applying the Cultural Approach to Cognitive Development (United States)

    Gauvain, Mary; Beebe, Heidi; Zhao, Shuheng


    Cognitive development is a cultural process. More experienced cultural members and the practices, institutions, and artifacts of the culture provide support and guidance for children as they develop knowledge and thinking skills. In this article, the authors describe the value that is added to our understanding of cognitive development when…

  20. Recent advances in co-amorphous drug formulations

    DEFF Research Database (Denmark)

    Dengale, Swapnil Jayant; Grohganz, Holger; Rades, Thomas


    with other amorphous stabilization techniques. Because of this, several research groups started to investigate the co-amorphous formulation approach, resulting in an increasing amount of scientific publications over the last few years. This study provides an overview of the co-amorphous field and its recent......Co-amorphous drug delivery systems have recently gained considerable interest in the pharmaceutical field because of their potential to improve oral bioavailability of poorly water-soluble drugs through drug dissolution enhancement as a result of the amorphous nature of the material. A co...... findings. In particular, we investigate co-amorphous formulations from the viewpoint of solid dispersions, describe their formation and mechanism of stabilization, study their impact on dissolution and in vivo performance and briefly outline the future potentials....

  1. A Cross-Cultural Approach to the Negotiation of Individual and Group Identities: Parliamentary Debates and Editorial Meetings (United States)

    Stewart, Miranda


    This article draws on interactional pragmatics and a cross-cultural approach (UK, France, Spain) to investigate the negotiation of individual and group identities in two different speech events, parliamentary debates and editorial meetings. The cross-cultural examination of the use of linguistic resources for signalling "social role,…

  2. The Cultural Approach to Studying Schools (United States)

    Appalachia Educational Laboratory at Edvantia (NJ1), 2005


    This paper presents key concepts from the theoretical literature on organizational change and school learning cultures. It concludes with eight actions school leaders can take to help school communities develop or enhance learning cultures that are receptive to change. [This report is based on a literature review by Albert J. Boerema.

  3. Investigating Preservice Teachers' Beliefs toward Cultural Diversity Employing an Inquiry through Literature Approach (United States)

    Rangseechatchawan, Dusadee


    This study investigated preservice teachers' beliefs toward cultural diversity by employing an inquiry through literature approach. The purpose of this study was to examine the impact of an inquiry through literature instructional format, such as book clubs, and whole class and individual inquiry, on preservice teachers' beliefs regarding cultural…

  4. Structural and Cultural Approaches Towards Studying the Diffusion of Management Practices


    Scheiber, Florian


    This dissertation combines so called structural and cultural approaches within diffusion research from organizational theory in order to contribute to gaining a deeper understanding for the spread of management practices. Therefore, three empirical cases are assessed using both qualitative and quantitative research methods: (1) The diffusion of codes of conduct among 287 firms in the German textile and apparel industry, (2) the diffusion of modern management practices among 272 German SMEs an...

  5. Stability and in vitro toxicity of an infliximab eye drop formulation. (United States)

    Robert, Marie-Claude; Spurr-Michaud, Sandra; Frenette, Mathieu; Young, David; Gipson, Ilene K; Dohlman, Claes H


    The purpose of this study was to develop a novel 10-mg/mL infliximab eye drop, to characterize its physical and biological stability under recommended storage conditions, and to assess the formulation's toxicity to ocular surface epithelium in vitro. Infliximab (10 mg/mL) was reconstituted using equal volumes of sterile water and 1% carboxymethylcellulose artificial tears. Aliquots were stored in either a 4 degrees C refrigerator or -20 degrees C freezer for up to 45 days. Physical stability was assessed through monitoring the solution's appearance, pH, ultraviolet-visible-near infrared absorbance and scattering, as well as protein gel electrophoresis. Biological stability was assayed through binding to tumor necrosis factor-alpha using an enzyme-linked immunosorbent assay. In vitro cytotoxicity to human corneal-limbal epithelial cells was examined following a 4-hour exposure to the study drug. Refrigerated and frozen infliximab eye drops remained clear and colorless for the duration of study. The formulation's pH (7.0) was comparable to that of the artificial tear vehicle alone. Low levels of ultraviolet-visible-near infrared light absorbance and scattering established the lack of protein precipitate after refrigeration or freezing. Protein gel electrophoresis performed under reducing conditions revealed the presence of two main protein bands of approximately 50 kDa and 25 kDa, representing immunoglobulin G heavy and light chains. The migration pattern of the proteins did not change under the different storage conditions and between day 10 and 45 after formulation. Infliximab binding to tumor necrosis factor-alpha remained stable for up to 45 days, with conservation of 101% and 102% of its initial binding activity when refrigerated or frozen, respectively. In vitro human corneal-limbal epithelial cultures showed no increase in cytotoxicity with infliximab treatment when compared to vehicle and culture media controls (P > 0.05). Infliximab can be formulated as an

  6. An Investigation of a Culturally Responsive Approach to Science Education in a Summer Program for Marginalized Youth (United States)

    Garvin, Brittany A.

    There have been numerous calls and efforts made to provide states, school districts, and communities needed financial support to increase and enhance access to and opportunities in Science, Technology, Engineering, and Math (STEM) related disciplines for marginalized populations (Tyson, Lee, & Hanson, 2007; Caldwell & Siwatu, 2003). As the challenge to better educate students of color and poor students intensifies, the need to provide equitable science learning experiences for all students aimed at scientific literacy and STEM also becomes critical. Thus the need to provide summer science enrichment programs where students engage in scientific experimentation, investigation, and critical thinking are vital to helping students who have been traditionally marginalized achieve success in school science and enter the science career pipeline. This mixed methods study examined the impact of a culturally responsive approach on student attitudes, interests in science education and STEM careers, and basic science content knowledge before and after participation in an upward bound summer program. Quantitative results indicated using a culturally responsive approach to teach science in an informal learning space significantly increases student achievement. Students receiving culturally responsive science instruction exhibited statistically significant increases in their posttest science scores compared to pretest science scores, M = 0.376, 95% CI [0.266, 0.487], t (10) = 7.610, p < 0.001. Likewise, students receiving culturally responsive science instruction had a significantly higher interest in science (M = 1.740, SD = 0.548) and STEM careers, M = 0.597, 95% CI [0.276, 0.919], p = 0.001. The qualitative data obtained in this study sought to gain a more in-depth understanding of the impact of a culturally responsive approach on students' attitudes, interests in science and STEM careers. Findings suggest providing students the opportunity to do and learn science utilizing a

  7. PNL vitrification technology development project glass formulation strategy for LLW vitrification

    International Nuclear Information System (INIS)

    Kim, D.; Hrma, P.R.; Westsik, J.H. Jr.


    This Glass Formulation Strategy describes development approaches to optimize glass compositions for Hanford's low-level waste vitrification between now and the projected low-level waste facility start-up in 2005. The objectives of the glass formulation task are to develop optimized glass compositions with satisfactory long-term durability, acceptable processing characteristics, adequate flexibility to handle waste variations, maximize waste loading to practical limits, and to develop methodology to respond to further waste variations

  8. Formulation of marketing information and communication strategies in Taiwan tourism industry


    Lee, Tzong-Ru; Kuo, Yu-Hsuan; Hilletofth, Per


    Purpose: The purpose of this research is to formulate marketing information and communication (ICT) strategies for Taiwan tourism industry. Design/methodology/approach: This research uses a literature review to identify problems and solutions of Taiwan’s tourism industry. One of the identified problems is used as an example to formulate marketing ICT strategies. Findings: This research has identified twenty-five main problems and forty-eight solutions of Taiwan’s tourism industry and formulat...

  9. Statistical formulation of gravitational radiation reaction

    International Nuclear Information System (INIS)

    Schutz, B.F.


    A new formulation of the radiation-reaction problem is proposed, which is simpler than alternatives which have been used before. The new approach is based on the initial-value problem, uses approximations which need be uniformly valid only in compact regions of space-time, and makes no time-asymmetric assumptions (no a priori introduction of retarded potentials or outgoing-wave asymptotic conditions). It defines radiation reaction to be the expected evolution of a source obtained by averaging over a statistical ensemble of initial conditions. The ensemble is chosen to reflect one's complete lack of information (in real systems) about the initial data for the radiation field. The approach is applied to the simple case of a weak-field, slow-motion source in general relativity, where it yields the usual expressions for radiation reaction when the gauge is chosen properly. There is a discussion of gauge freedom, and another of the necessity of taking into account reaction corrections to the particle-conservation equation. The analogy with the second law of thermodynamics is very close, and suggests that the electromagnetic and thermodynamic arrows of time are the same. Because the formulation is based on the usual initial-value problem, it has no spurious ''runaway'' solutions

  10. The Enterprise Value Creation Management Process and Intangible Assets - the CERM/ROIAM Approach (Japanese)


    KARIYA Takeaki


    As Robert Redfield has stated, culture is a shared common knowledge and understanding to be manifested in behavior and processed goods. Intangible assets are the fundamental source of enterprise value creation. In this paper we first aim to clarify the compound, complex and multilayered processes whereby intangible assets contribute to value creation, and then aim to formulate the framework of an effective and comprehensive management process referred to as CERM/ROIAM. This approach makes it ...

  11. Exploring Education Culture by Employing Hofstede?s Cultural Dimensions to Evaluate the Effectiveness of the Current ERP Training Approach in Thailand (United States)

    Chayakonvikom, Monta; Fuangvut, Parin; Cannell, Stephen


    ERP training is a critical success factor in ERP implementation. The current ERP training was largely ineffective and caused user resistance and ERP implementation failure. The objective of this paper is to investigate whether the current ERP training approach can accommodate the cultural learning behaviors of end-users. Hofstede's cultural…

  12. Two different formulations of the heavy quark effective theory

    International Nuclear Information System (INIS)

    Balk, S.; Ilakovac, A.; Koerner, J.G.; Pirjol, D.


    We point out that there exist two different formulations of the Heavy Quark Effective Theory (HQET). The one formulation of HQET was mostly developed at Harvard and involves the use of the equation of motion to eliminate the small components of the heavy quark field. The second formulation, developed in Mainz, involves a series of Foldy-Wouthuysen-type field transformations which diagonalizes the heavy quark Lagrangian in terms of an effective quark and antiquark sector. Starting at O(1/m Q 2 ) the two formulations are different in that their effective Lagrangians, their effective currents, and their effective wave functions differ. However, when these three differences are properly taken into account, the two alternative formulations lead to identical transition or S-matrix elements. This is demonstrated in an explicit example at O(1/m Q 2 ). We point to an essential difficulty of the Harvard HQET in that the Harvard effective fields are not properly normalized starting at order O(1/m Q 2 ). We provide explicit higher order expressions for the effective fields and the Lagrangian in the Mainz approach, and write down an O(1/m Q 2 ) nonabelian version of the Pauli equation for the heavy quark effective field. (orig.)

  13. Random path formulation of nonrelativistic quantum mechanics

    International Nuclear Information System (INIS)

    Roncadelli, M.


    Quantum amplitudes satisfy (almost) the same calculus that probabilities obey in the theory of classical stochastic diffusion processes. As a consequence of this structural analogy, a new formulation of (nonrelativistic) quantum mechanics naturally arises as the quantum counterpart of the Langevin description of (classical) stochastic diffusion processes. Quantum fluctuations are simulated here by a Fresnel white noise (FWN), which is a (real) white noise with imaginary diffusion constant, whose functional (pseudo) measure yields the amplitude distribution for its configurations. Central to this approach is the idea that classical dynamical trajectories in configuration space are perturbed by the FWN. Hence, a single (arbitrary) classical dynamical path gets replaced by a family of quantum random paths (QRPs) - one for each FWN sample - all originating from the same space-time point (x', t'). The QRPs are the basic objects of the present formulation and are given by a Langevin equation with the FWN, whose drift is controlled by a (arbitrary) solution to the classical Hamilton-Jacobi equation. So, our approach is manifestly based on classical dynamics. Now, a transition amplitude is associated with each QRP: it gives the amplitude that a particle starting from (x', t') will reach (x'', t'') by travelling just along the considered QRP. The quantum mechanical propagator (x'', t'' modul x', t') then emerges as the FWN average of the transition amplitude along a QRP. Thus, quantum mechanics looks like classical mechanics as perturbed by the FWN. The general structure of this formulation is discussed in detail, along with some practical and conceptual implications. (author). 14 refs

  14. Optimisation of the formulation of a bubble bath by a chemometric approach market segmentation and optimisation. (United States)

    Marengo, Emilio; Robotti, Elisa; Gennaro, Maria Carla; Bertetto, Mariella


    The optimisation of the formulation of a commercial bubble bath was performed by chemometric analysis of Panel Tests results. A first Panel Test was performed to choose the best essence, among four proposed to the consumers; the best essence chosen was used in the revised commercial bubble bath. Afterwards, the effect of changing the amount of four components (the amount of primary surfactant, the essence, the hydratant and the colouring agent) of the bubble bath was studied by a fractional factorial design. The segmentation of the bubble bath market was performed by a second Panel Test, in which the consumers were requested to evaluate the samples coming from the experimental design. The results were then treated by Principal Component Analysis. The market had two segments: people preferring a product with a rich formulation and people preferring a poor product. The final target, i.e. the optimisation of the formulation for each segment, was obtained by the calculation of regression models relating the subjective evaluations given by the Panel and the compositions of the samples. The regression models allowed to identify the best formulations for the two segments ofthe market.

  15. A personalized and control systems engineering conceptual approach to target childhood anxiety in the contexts of cultural diversity. (United States)

    Pina, Armando A; Holly, Lindsay E; Zerr, Argero A; Rivera, Daniel E


    In the child and adolescent anxiety area, some progress has been made to develop evidence-based prevention protocols, but less is known about how to best target these problems in children and families of color. In general, data show differential program effects with some minority children benefiting significantly less. Our preliminary data, however, show promise and suggest cultural parameters to consider in the tailoring process beyond language and cultural symbols. It appears that a more focused approach to culture might help activate intervention components and its intended effects by focusing, for example, on the various facets of familismo when working with some Mexican parents. However, testing the effects and nuances of cultural adaption vis-à-vis a focused personalized approach is methodologically challenging. For this reason, we identify control systems engineering design methods and provide example scenarios relevant to our data and recent intervention work.

  16. Nanoparticle dispersion in environmentally relevant culture media: a TiO2 case study and considerations for a general approach

    International Nuclear Information System (INIS)

    Horst, Allison M.; Ji, Zhaoxia; Holden, Patricia A.


    Nanoparticle exposure in toxicity studies requires that nanoparticles are bioavailable by remaining highly dispersed in culture media. However, reported dispersion approaches are variable, mostly study-specific, and not transferable owing to their empirical basis. Furthermore, many published approaches employ proteinaceous dispersants in rich laboratory media, both of which represent end members in environmental scenarios. Here, a systematic approach was developed to disperse initially agglomerated TiO 2 nanoparticles (Aeroxide® TiO 2 P25, Evonik, NJ; primary particle size range 6.4–73.8 nm) in oligotrophic culture medium for environmentally relevant bacterial toxicity studies. Based on understanding particle–particle interactions in aqueous media and maintaining environmental relevance, the approach involves (1) quantifying the relationship between pH and zeta potential to determine the point of zero charge of select nanoparticles in water; (2) nominating, then testing and selecting, environmentally relevant stabilizing agents; and (3) dispersing via “condition and capture” whereby stock dry powder nanoparticles are sonicated in pre-conditioned (with base, or acid, plus stabilizing agent) water, then diluted into culture media. The “condition and capture” principle is transferable to other nanoparticle and media chemistries: simultaneously, mechanically and electrostatically, nanoparticles can be dispersed with surrounding stabilizers that coat and sterically hinder reagglomeration in the culture medium.

  17. A Cell Culture Approach to Optimized Human Corneal Endothelial Cell Function (United States)

    Bartakova, Alena; Kuzmenko, Olga; Alvarez-Delfin, Karen; Kunzevitzky, Noelia J.; Goldberg, Jeffrey L.


    Purpose Cell-based therapies to replace corneal endothelium depend on culture methods to optimize human corneal endothelial cell (HCEC) function and minimize endothelial-mesenchymal transition (EnMT). Here we explore contribution of low-mitogenic media on stabilization of phenotypes in vitro that mimic those of HCECs in vivo. Methods HCECs were isolated from cadaveric donor corneas and expanded in vitro, comparing continuous presence of exogenous growth factors (“proliferative media”) to media without those factors (“stabilizing media”). Identity based on canonical morphology and expression of surface marker CD56, and function based on formation of tight junction barriers measured by trans-endothelial electrical resistance assays (TEER) were assessed. Results Primary HCECs cultured in proliferative media underwent EnMT after three to four passages, becoming increasingly fibroblastic. Stabilizing the cells before each passage by switching them to a media low in mitogenic growth factors and serum preserved canonical morphology and yielded a higher number of cells. HCECs cultured in stabilizing media increased both expression of the identity marker CD56 and also tight junction monolayer integrity compared to cells cultured without stabilization. Conclusions HCECs isolated from donor corneas and expanded in vitro with a low-mitogenic media stabilizing step before each passage demonstrate more canonical structural and functional features and defer EnMT, increasing the number of passages and total canonical cell yield. This approach may facilitate development of HCEC-based cell therapies. PMID:29625488


    Directory of Open Access Journals (Sweden)

    Marius Costel Esi


    Full Text Available The economic activity goals reveal a number of aspects which express the need for re-evaluating the way in which the dynamics analysis values may be correlated with the wording business mission. Under these conditions, managerial undertaken strategies at the level of business may be validated in so far as they reveal purpose/ objectives assumed/ undertaken by decision makers (particularly top-managers. Moreover, compliance with eligibility criteria according to which management strategies are reflected, should be aimed at in our opinion improving decision-making process. But such a decision-making process involves an understanding of the judicious economic actors/ labor with regard to the way in which it is possible to analyze the dynamics values in relation to formulation  of  business organization's mission. In these circumstances, a first objective of this research is analysis dynamics values in the context of formulation of business mission. In this way, by this approach, we strive to show you those conditionings that make it possible formulation of business mission in relation to organizational culture.  On the other hand, a second objective that we have in view is given of the way in which is to bring about the process of defining and statement of organizational mission, a process linked to the size of axiological mission statement of business organization. This status as a matter of fact, in the light of the analysis we take into account,  a business model in which the objectives, strategies, organization mission business become materialized in so far as that contextuality  venture is validated in relation to socio-economic prospects. Therefore, the existence of phenomena such as social and economic situation involves a series of connections between different levels of displacing of the organization of business which provides, in fact, its legitimacy

  19. Crystallization Formulation Lab (United States)

    Federal Laboratory Consortium — The Crystallization Formulation Lab fills a critical need in the process development and optimization of current and new explosives and energetic formulations. The...


    Directory of Open Access Journals (Sweden)

    Dian Anggraeni


    Full Text Available Makalah ini melaporkan temuan satu eksperimen dengan disain pretest-postest dengan kelompok kontrol dan menerapkan pendekatan kontekstual dan strategi formulate-share-listen-create (FSLC, untuk menelaah kemampuan pemahaman dan komunikasi matematik siswa SMK. Subyek penelitian ini adalah 80 siswa SMK program keahlian pemasaran di Bandung. Instrumen penelitian terdiri dari tes kemampuan pemahaman dan komunikasi matematik serta disposisi matematik. Berdasarkan analisis data menggunakan SPSS 16.0 dan Microsoft Excel 2010, penelitian menemukan: Pencapaian dan peningkatan kemampuan pemahaman dan komunikasi matematik siswa yang memperoleh pendekatan kontekstual dan strategi formulate-share-listen-create (FSLC lebih baik daripada pencapaian dan peningkatan kemampuan siswa yang memperoleh pembelajaran konvensional.  Penelitian juga menemukan adanya asosiasi sedang antara kemampuan pemahaman dan komunikasi matematik, dan siswa menunjukkan disposisi matematik yang positif terhadap pendekatan kontekstual dan strategi formulate-share-listen-create (FSLC   Kata Kunci    : pendekatan kontekstual, strategi formulate-share-listen-create, pemahaman dan komunikasi matematik, disposisi matematik     This paper reports the findings from an experimental prettest-posttest control group design conducted by using contextual approach and formulate-share-listen-create (FSLC strategy to investigate students’ mathematical understanding and communication abilities.The study involved 80 grade-11 students from SMK of marketing field program in Bandung. The instrumens of this study are mathematical undestanding test, mathematical communication test, and mathematical disposistion scale. By using SPSS 16.0 and Microsoft Excel 2010, the study found the contextual approach and formulate-share-listen-create (FSLC strategy was able to improve students’ mathematical understanding and mathematical communication abilities better than that of conventional approach. Students

  1. Biodeterioration of epoxy resin: a microbial survey through culture-independent and culture-dependent approaches. (United States)

    Pangallo, Domenico; Bučková, Maria; Kraková, Lucia; Puškárová, Andrea; Šaková, Nikoleta; Grivalský, Tomaš; Chovanová, Katarina; Zemánková, Milina


    During the 20th century, synthetic polymers were greatly used in the field of art. In particular, the epoxy resins were used for both conservation and for creating sculptures. The biodeterioration of these polymers has not been adequately studied. The aim of this investigation was to examine the microflora responsible for the deterioration of an epoxy statue exposed to outdoor conditions. Fungal and bacterial microflora were isolated from the art object, clustered by fluorescence-ITS (internal transcribed spacer), identified by ITS and 16S rRNA sequencing and tested for their lipolytic abilities by three agar assays. Different algal, bacterial, cyanobacterial and fungal clone libraries were constructed. The surrounding airborne microflora was analyzed using culture-dependent and culture-independent approaches. The results indicated the presence, on the statue surface, of an interesting and differentiate microbial community composed of rock-inhabiting members, algal photobionts (Trebouxia spp., Chloroidium ellipsoideum and Chlorella angustoellipsoidea), Cyanobacteria (Leptolyngbya sp., Phormidium sp., Cylindrospermum stagnale, Hassallia byssoidea and Geitlerinema sp.), black yeasts related to the species Friedmanniomyces endolithicus, Pseudotaeniolina globosa, Phaeococcomyces catenatus and Catenulostroma germanicum and several plant-associated fungi. This investigation provides new information on the potential microfloral inhabitants of epoxy resin discovering a new ecological niche, occupied mainly by several members of rock-colonizing microbial species. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

  2. The motivation to study in the light of the Historical Cultural Approach

    Directory of Open Access Journals (Sweden)

    Luis Alfredo González Collera


    Full Text Available In this article: Motivation to study in the light of the historical-cultural approach, it is made a critical and historical analysis of the antecedents of the process of motivation, from the theoretical and methodological point of view. The works made by researchers and followers of this approach are remarked, and it is presented the theoretical bases for the study and development of the process of motivation and motivation for study at present. It denotes the necessity and the importance of the revision of these contents for elaborating new problems to be solved in this area of educative and human development.

  3. Cultural entrepreneurship

    NARCIS (Netherlands)

    A. Klamer (Arjo)


    textabstractCultural entrepreneurship is a new character in the cultural sector. This paper characterizes the cultural entrepreneur paying homage to the hermeneutic approach of Don Lavoie and others. The challenge is to render the "cultural" meaningful. An invention is the highlighting of the

  4. Modeling evolution of the mind and cultures: emotional Sapir-Whorf hypothesis (United States)

    Perlovsky, Leonid I.


    Evolution of cultures is ultimately determined by mechanisms of the human mind. The paper discusses the mechanisms of evolution of language from primordial undifferentiated animal cries to contemporary conceptual contents. In parallel with differentiation of conceptual contents, the conceptual contents were differentiated from emotional contents of languages. The paper suggests the neural brain mechanisms involved in these processes. Experimental evidence and theoretical arguments are discussed, including mathematical approaches to cognition and language: modeling fields theory, the knowledge instinct, and the dual model connecting language and cognition. Mathematical results are related to cognitive science, linguistics, and psychology. The paper gives an initial mathematical formulation and mean-field equations for the hierarchical dynamics of both the human mind and culture. In the mind heterarchy operation of the knowledge instinct manifests through mechanisms of differentiation and synthesis. The emotional contents of language are related to language grammar. The conclusion is an emotional version of Sapir-Whorf hypothesis. Cultural advantages of "conceptual" pragmatic cultures, in which emotionality of language is diminished and differentiation overtakes synthesis resulting in fast evolution at the price of self doubts and internal crises are compared to those of traditional cultures where differentiation lags behind synthesis, resulting in cultural stability at the price of stagnation. Multi-language, multi-ethnic society might combine the benefits of stability and fast differentiation. Unsolved problems and future theoretical and experimental directions are discussed.

  5. Unifying the concept of consciousness across the disciplines: A concept-based, cross-cultural approach (United States)

    Jones, Peter N.

    The majority of studies concerning consciousness have examined and modeled the concept of consciousness in terms of particular lines of inquiry, a process that has circumscribed the general applicability of any results from such approaches. The purpose of this dissertation was to study consciousness from a concept-based, cross-cultural approach and to attempt to unify the concept across the cultures examined. The 4 cultures are the academic disciplines of philosophy, physics, psychology, and anthropology. Consciousness was examined in terms of how the concept is framed and where the major limitations in each line of inquiry occur. The rationale for examining consciousness as a concept across 4 cultures was to determine whether there was any common component in each line's framing that could be used to unify the concept. The study found that experience itself was the primary unifying factor in each field's framing and that experience was treated as a nonreducible property within each line of inquiry. By taking experience itself (but not subjective experience) as a fundamental property, each culture's concept of consciousness becomes tractable. As such, this dissertation argues that experience should be taken as a fundamental property of the concept. The significance of this analysis is that by taking experience as a fundamental property, it becomes possible to unify the concept across the 4 cultures. This unification is presented as a unity thesis, which is a theory arguing for unification of the concept based on the fundamental of experience. Following this theoretical examination, this paper discusses several key implications of the unity thesis, including implications of the unity thesis for the current status of altered states of consciousness and for the so-called hard and easy problems associated with the concept (at least within Occidental ontology). It is argued that the so-called hard problem does not exist when experience is taken as a fundamental property

  6. IAEA’s Approach to Leadership, Management and Culture for Safety

    International Nuclear Information System (INIS)

    Rzentkowski, G.


    In this session the director of the Division of Nuclear Installation Safety (NSNI) will describe the division’s approach to leadership, management and culture for safety and outline the strategy adopted for this work. The IAEA has developed a safety culture foundation framework which is used to support all installations’ and organisations’ work for continuous improvement to achieve excellence in nuclear safety performance. The framework has been developing since 1986 through the work of the IAEA and the nuclear community, and is based on nuclear organisations’ experiences (both in practices applied and events experienced) and the development of scientific knowledge on human and organisation factors that support nuclear safety performance. The main aim for the IAEA is to assist the Member States to translate the knowledge into practical and successful practise, and to further enhance the safety on nuclear installations. The Strategy of the division is to share the common foundation of the framework across the different nuclear sectors and ensure that application of improvement activities are firmly based on knowledge and appropriate context based solutions.

  7. Aspects of western cultural, Intolerance: on the hermeneutical approach to the Mah–abh–arata

    Directory of Open Access Journals (Sweden)

    Carmen Dragonetti


    Full Text Available There are frequent manifestations of Western cultural intolerance that prevent a scientific neutral approach to the intellectual achievements of other cultures, and also to appreciate them in their actual value. The authors of this article first refer to examples of this kind of intolerance in the field of Philosophy (which has been the principal object of their last investigations, Religion (Buddhist Atheism, and Linguistics (the «discovery» of Sanskrit language by Western scholars. In the present paper they specifically deal with the hermeneutical approach by Western scholars to the Mah–abh–arata that the authors consider the most important work in World Literature: Intolerance in this matter makes scholars find in the Mah–abh–arata a real «chaos» or conduces them to the obsessive search for the «Ur-Text», giving rise to theories that eliminate large portions of the epic poem considering them interpolations, or negating it all creativity, originality, and even its Indian essence. The last part of the article is dedicated to Krsna, an avatara, i.e. a reincarnation or manifestation, of the Supreme God Visnu. Krsna is seen as «a bizarre figure», «a cynic», «an opportunist», «a charlatan, who declares himself to be the God of Gods». These Western scholars leave completely aside the Indian tradition of almost three thousand centuries that proclaims that Krsna is not a God, but the God of the Hindu people, being adored by many devoted hearts. A simple but important hermeneutical norm has been forgotten: To accept the cultural products created by another culture as they are conceived by it, and without interpreting them according to one’s one cultural criteria based on the own values and beliefs.

  8. Marxism in Vygotskian approaches to cultural studies of science education (United States)

    Lima Junior, Paulo; Ostermann, Fernanda; Rezende, Flavia


    In this paper we initially address the main categories of Marxism, illustrating how Vygotsky has appropriated them as mediational meta-theoretical tools for building concepts for his psychological approach. In order to investigate the influence of Marxism in cultural studies of science education, we make an account of how current research, sustained by Vygotsky's original and successor theories, has been appropriating meta-theoretical categories of dialectical materialism. Once we identified Cultural Studies of Science Education as a journal that would probably concentrate papers that follow these perspectives, we decided to take it as the context of this study. In the process of selecting the corpus to be reviewed from the editions published from 2006 to 2011, we have found that 16 % of the articles that matched keywords denoting frameworks related to the Vygotskian tradition developed and appropriated the categories of dialectical materialism. The quality and originality of contemporary development of CHAT denote that this framework has been playing a very important role in recent expansion of Vygotskian approaches to research in science education. Among the papers that we considered to develop and appropriate Vygotskian frameworks, incompletion in the appropriation of meta-theoretical categories of dialectical materialism and the misusage of dialectics intertwined with dialogism were highlighted. Our findings suggest that overcoming these limitations can enhance political analysis of sociocultural phenomena in the context of science education. It also represents a strengthening of the role of dialectical materialism in expanding sociocultural perspectives toward a better articulation between individual and institutional-centered analyses.

  9. The safety culture according to a comprehensive approach. A contribution to risk governance within complex systems. Doctoral thesis prepared at SCK-CEN and defended in 2004

    International Nuclear Information System (INIS)

    Fucks, I.


    The article refers to an abstract of a doctoral thesis. This PhD is based on two evolutions within the society concerning the way to manage modern risks. It is more and more acknowledged that, firstly, rational scientific models are no longer capable to explain and manage the complexity and the diversity of risks. Secondly the supporters of a democratic conception of the risk governance claim that the risk management can benefit from the participation of the lay people to the debate. Within this framework, the study of safety culture, according to a bottom-up and comprehensive approach, in the field of the social sciences, represents an opportunity to make concrete the risk governance principle within complex system (such as a nuclear power plant and a nuclear research centre). The objectives of this PhD are the following: to appreciate the participation of the workers to the debate of the risk management within organisations; to present the lessons which can be drawn from this exercise and finally to investigate the safety culture of different groups of workers adopting an alternative view as compared to the vision as formulated in the present texts of the IAEA.The methodology was based on two techniques: observation and Focus Group. The observations were planed to feed further the Focus Group discussions with concrete examples of situations at work. We organized different Focus Group discussions with different kinds of workers (workers, managers, safety officers) in order to collect the social representation relating to the safety, the organization, the technology, the socio-economical environment and the work of each of these groups, both in the Belgian Nuclear Research Centre and in the Nuclear Power Plant of Tricastin in France. The results confirm firstly the relevance of developing a multidisciplinary theoretical framework of safety culture drawing its inspiration from sociology, social psychology, anthropology, etc. This multidisciplinary approach allows

  10. The dynamic interplay among EFL learners’ ambiguity tolerance, adaptability, cultural intelligence, learning approach, and language achievement

    Directory of Open Access Journals (Sweden)

    Shadi Alahdadi


    Full Text Available A key objective of education is to prepare individuals to be fully-functioning learners. This entails developing the cognitive, metacognitive, motivational, cultural, and emotional competencies. The present study aimed to examine the interrelationships among adaptability, tolerance of ambiguity, cultural intelligence, learning approach, and language achievement as manifestations of the above competencies within a single model. The participants comprised one hundred eighty BA and MA Iranian university students studying English language teaching and translation. The instruments used in this study consisted of the translated versions of four questionnaires: second language tolerance of ambiguity scale, adaptability taken from emotional intelligence inventory, cultural intelligence (CQ inventory, and the revised study process questionnaire measuring surface and deep learning. The results estimated via structural equation modeling (SEM revealed that the proposed model containing the variables under study had a good fit with the data. It was found that all the variables except adaptability directly influenced language achievement with deep approach having the highest impact and ambiguity tolerance having the lowest influence. In addition, ambiguity tolerance was a positive and significant predictor of deep approach. CQ was found to be under the influence of both ambiguity tolerance and adaptability. The findings were discussed in the light of the yielded results.

  11. Lithium-ion battery capacity fading dynamics modelling for formulation optimization: A stochastic approach to accelerate the design process

    International Nuclear Information System (INIS)

    Tao, Laifa; Cheng, Yujie; Lu, Chen; Su, Yuzhuan; Chong, Jin; Jin, Haizu; Lin, Yongshou; Noktehdan, Azadeh


    Highlights: •The model is linked to known physicochemical degradation processes and material properties. •Aging dynamics of various battery formulations can be understood by the proposed model. •Large number of experiments will be reduced to accelerate the battery design process. •This approach can describe batteries under various operating conditions. •The proposed model is simple and easily implemented. -- Abstract: A five-state nonhomogeneous Markov chain model, which is an effective and promising way to accelerate the Li-ion battery design process by investigating the capacity fading dynamics of different formulations during the battery design phase, is reported. The parameters of this model are linked to known physicochemical degradation dynamics and material properties. Herein, the states and behaviors of the active materials in Li-ion batteries are modelled. To verify the efficiency of the proposed model, a dataset from approximately 3 years of cycling capacity fading experiments of various formulations using several different materials provided by Contemporary Amperex Technology Limited (CATL), as well as a NASA dataset, are employed. The capabilities of the proposed model for different amounts (50%, 70%, and 90%) of available experimental capacity data are tested and analyzed to assist with the final design determination for manufacturers. The average relative errors of life cycling prediction acquired from these tests are less than 2.4%, 0.8%, and 0.3%, even when only 50%, 70%, and 90% of the data, respectively, is available for different anode materials, electrolyte materials, and individual batteries. Furthermore, the variance is 0.518% when only 50% of the data are available; i.e., one can save at least 50% of the total experimental time and cost with an accuracy greater than 97% in the design phase, which demonstrates an effective and promising way to accelerate the Li-ion battery design process. The qualitative and quantitative analyses


    Directory of Open Access Journals (Sweden)

    Grujo Bjeković


    Full Text Available Inaugural discusses of metatheoretical innovatinal forming of upgrading the cultural health and pedagogical technology of children’s and youth’s health progress and protection systems in the system of generally educational and health-school organizations. Establishment of a dynamical cumulative knowledge exchange and cooperative harmonization of the pedagogues of teaching obligations in the constitution of knowledge management educational space on rising health culture, physicality, and enriching sport and recreative lifestyle. Working out of con ceptual structural-functional scheme of health management measures in school and of evaluation of psychophysical and functional potentials, from the aspect of personalorientation. Establishment of complex system monitoring for physical development and physical capabilities and achieved results in domain of self-organized sport and sport-recreative selected activities.

  13. Exploring Integrated Marketing Communications, Brand Awareness, and Brand Image in Hospitality Marketing: A Cross-Cultural Approach


    Maja Šerić; Irene Gil Saura; Josip Mikulić


    Purpose – The purpose of this paper is to assess customer perceptions of integration of marketing communications, brand awareness, and brand image in hospitality. Moreover, cross-cultural differences are considered when evaluating all the concepts, since national culture can have a considerable impact on customer behavior. Design/Methodology/Approach – After a literature review of the examined concepts, the results of an empirical study are presented and discussed. The empirical investigat...

  14. Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery. (United States)

    Balakrishnan, Prabagar; Shanmugam, Srinivasan; Lee, Won Seok; Lee, Won Mo; Kim, Jong Oh; Oh, Dong Hoon; Kim, Dae-Duk; Kim, Jung Sun; Yoo, Bong Kyu; Choi, Han-Gon; Woo, Jong Soo; Yong, Chul Soon


    Niosomes have been reported as a possible approach to improve the low skin penetration and bioavailability characteristics shown by conventional topical vehicle for minoxidil. Niosomes formed from polyoxyethylene alkyl ethers (Brij) or sorbitan monoesters (Span) with cholesterol molar ratios of 0, 1 and 1.5 were prepared with varying drug amount 20-50mg using thin film-hydration method. The prepared systems were characterized for entrapment efficiency, particle size, zeta potential and stability. Skin permeation studies were performed using static vertical diffusion Franz cells and hairless mouse skin treated with either niosomes, control minoxidil solution (propylene glycol-water-ethanol at 20:30:50, v/v/v) or a leading topical minoxidil commercial formulation (Minoxyl). The results showed that the type of surfactant, cholesterol and incorporated amount of drug altered the entrapment efficiency of niosomes. Higher entrapment efficiency was obtained with the niosomes prepared from Span 60 and cholesterol at 1:1 molar ratio using 25mg drug. Niosomal formulations have shown a fairly high retention of minoxidil inside the vesicles (80%) at refrigerated temperature up to a period of 3 months. It was observed that both dialyzed and non-dialyzed niosomal formulations (1.03+/-0.18 to 19.41+/-4.04%) enhanced the percentage of dose accumulated in the skin compared to commercial and control formulations (0.11+/-0.03 to 0.48+/-0.17%) except dialyzed Span 60 niosomes. The greatest skin accumulation was always obtained with non-dialyzed vesicular formulations. Our results suggest that these niosomal formulations could constitute a promising approach for the topical delivery of minoxidil in hair loss treatment.

  15. A Cultural Approach to Understanding Professional Experiences of Foreign-Born Faculty in U.S. Educational Leadership Preparation Programs (United States)

    Khrabrova, Iryna; Sanzo, Karen L.


    The purpose of this study was to investigate the professional experiences of foreign-born faculty members serving in U.S. educational leadership preparation programs, utilizing a cultural approach to discern their lived experiences related to professional life. Cultural values were explored as reflected in professional life experiences. The…

  16. A signed particle formulation of non-relativistic quantum mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Sellier, Jean Michel, E-mail:


    A formulation of non-relativistic quantum mechanics in terms of Newtonian particles is presented in the shape of a set of three postulates. In this new theory, quantum systems are described by ensembles of signed particles which behave as field-less classical objects which carry a negative or positive sign and interact with an external potential by means of creation and annihilation events only. This approach is shown to be a generalization of the signed particle Wigner Monte Carlo method which reconstructs the time-dependent Wigner quasi-distribution function of a system and, therefore, the corresponding Schrödinger time-dependent wave-function. Its classical limit is discussed and a physical interpretation, based on experimental evidences coming from quantum tomography, is suggested. Moreover, in order to show the advantages brought by this novel formulation, a straightforward extension to relativistic effects is discussed. To conclude, quantum tunnelling numerical experiments are performed to show the validity of the suggested approach.

  17. How Does a Newcomer Construct Identity? A Socio-Cultural Approach to Workplace Learning (United States)

    Blaka, Gunnhild; Filstad, Cathrine


    The aim of this article is to develop the foundations of a socio-cultural approach and to determine how this shapes our perception of a newcomer's construction of identity in two different workplaces: a high-technology delivery ward with newly employed midwives and a real estate agency with newly employed real estate agents. We explore how…

  18. Cultural transmission and the evolution of human behaviour: a general approach based on the Price equation. (United States)

    El Mouden, C; André, J-B; Morin, O; Nettle, D


    Transmitted culture can be viewed as an inheritance system somewhat independent of genes that is subject to processes of descent with modification in its own right. Although many authors have conceptualized cultural change as a Darwinian process, there is no generally agreed formal framework for defining key concepts such as natural selection, fitness, relatedness and altruism for the cultural case. Here, we present and explore such a framework using the Price equation. Assuming an isolated, independently measurable culturally transmitted trait, we show that cultural natural selection maximizes cultural fitness, a distinct quantity from genetic fitness, and also that cultural relatedness and cultural altruism are not reducible to or necessarily related to their genetic counterparts. We show that antagonistic coevolution will occur between genes and culture whenever cultural fitness is not perfectly aligned with genetic fitness, as genetic selection will shape psychological mechanisms to avoid susceptibility to cultural traits that bear a genetic fitness cost. We discuss the difficulties with conceptualizing cultural change using the framework of evolutionary theory, the degree to which cultural evolution is autonomous from genetic evolution, and the extent to which cultural change should be seen as a Darwinian process. We argue that the nonselection components of evolutionary change are much more important for culture than for genes, and that this and other important differences from the genetic case mean that different approaches and emphases are needed for cultural than genetic processes. © 2013 The Authors. Journal of Evolutionary Biology © 2013 European Society For Evolutionary Biology.

  19. Approaching Africa: The Reception of African Visual Culture in Germany 1894-1915


    Husemann, Manuela


    This thesis focuses on the approaches to African visual culture in German publications between 1894 and 1915. Considering the development from a purely ethnographic analysis towards an art historical and art scientific discourse, it brings together formerly unconnected fields of research. By introducing theories from translation studies this thesis will identify how scholars from different disciplines analysed and interpreted African art in order to mediate their function, meaning and form...

  20. Formulating informative, data-based priors for failure probability estimation in reliability analysis

    International Nuclear Information System (INIS)

    Guikema, Seth D.


    Priors play an important role in the use of Bayesian methods in risk analysis, and using all available information to formulate an informative prior can lead to more accurate posterior inferences. This paper examines the practical implications of using five different methods for formulating an informative prior for a failure probability based on past data. These methods are the method of moments, maximum likelihood (ML) estimation, maximum entropy estimation, starting from a non-informative 'pre-prior', and fitting a prior based on confidence/credible interval matching. The priors resulting from the use of these different methods are compared qualitatively, and the posteriors are compared quantitatively based on a number of different scenarios of observed data used to update the priors. The results show that the amount of information assumed in the prior makes a critical difference in the accuracy of the posterior inferences. For situations in which the data used to formulate the informative prior is an accurate reflection of the data that is later observed, the ML approach yields the minimum variance posterior. However, the maximum entropy approach is more robust to differences between the data used to formulate the prior and the observed data because it maximizes the uncertainty in the prior subject to the constraints imposed by the past data

  1. Development of a goat fermented milk with probiotics starter culture

    Directory of Open Access Journals (Sweden)

    Aldo Hernández-Monzón


    Full Text Available The goat milk for their multiple properties nutraceutical and for the high yield of their derived products, it represents an interesting commercial alternative for the elaboration of special fermented milk. At the present time the probiotics starter culture for their proven properties are used thoroughly in the elaboration of fermented milk. Keeping in mind these antecedents this work had as objective to develop a fermented milk of goat with characteristic probiotics, good acceptability and appropriate shelf life using the starter culture Lactobacillus casei, Lactobacillus acidophilus jointly with the starter culture of the yogurt. It was carried out a design of experiment of response surface (22 with the independent variables, starter culture dose (1.5 to 2.5% and the relationship of starter culture of yogurt: probiotics starter culture 1:3 at 1:5. As variable answers they took: the viability, the acidity and the sensorial indicators. The formulation selected with the best characteristics was conserved to temperature of 4 oC for the evaluation of the storage life. The best formulation was the 2% starter culture with a relationship of 1:4. The fermented milk was evaluated of “I like” and its viability was above the therapeutic minimum until the 21 days (log (UFC/ml of 8.8 at 7.0.

  2. Audits of radiopharmaceutical formulations

    International Nuclear Information System (INIS)

    Castronovo, F.P. Jr.


    A procedure for auditing radiopharmaceutical formulations is described. To meet FDA guidelines regarding the quality of radiopharmaceuticals, institutional radioactive drug research committees perform audits when such drugs are formulated away from an institutional pharmacy. All principal investigators who formulate drugs outside institutional pharmacies must pass these audits before they can obtain a radiopharmaceutical investigation permit. The audit team meets with the individual who performs the formulation at the site of drug preparation to verify that drug formulations meet identity, strength, quality, and purity standards; are uniform and reproducible; and are sterile and pyrogen free. This team must contain an expert knowledgeable in the preparation of radioactive drugs; a radiopharmacist is the most qualified person for this role. Problems that have been identified by audits include lack of sterility and apyrogenicity testing, formulations that are open to the laboratory environment, failure to use pharmaceutical-grade chemicals, inadequate quality control methods or records, inadequate training of the person preparing the drug, and improper unit dose preparation. Investigational radiopharmaceutical formulations, including nonradiolabeled drugs, must be audited before they are administered to humans. A properly trained pharmacist should be a member of the audit team

  3. Integrative approach to produce hydrogen and polyhydroxybutyrate from biowaste using defined bacterial cultures. (United States)

    Patel, Sanjay K S; Kumar, Prasun; Singh, Mamtesh; Lee, Jung-Kul; Kalia, Vipin C


    Biological production of hydrogen (H2) and polyhydroxybutyrate (PHB) from pea-shell slurry (PSS) was investigated using defined mixed culture (MMC4, composed of Enterobacter, Proteus, Bacillus spp.). Under batch culture, 19.0LH2/kg of PSS (total solid, TS, 2%w/v) was evolved. Using effluent from the H2 producing stage, Bacillus cereus EGU43 could produce 12.4% (w/w) PHB. Dilutions of PSS hydrolysate containing glucose (0.5%, w/v) resulted in 45-75LH2/kg TS fed and 19.1% (w/w) of PHB content. Under continuous culture, MMC4 immobilized on coconut coir (CC) lead to an H2 yield of 54L/kg TS fed and a PHB content of 64.7% (w/w). An improvement of 2- and 3.7-fold in H2 and PHB yields were achieved in comparison to control. This integrative approach using defined set of bacterial strains can prove effective in producing biomolecules from biowastes. Copyright © 2014. Published by Elsevier Ltd.

  4. Canonical formulation of general-relativistic theories

    International Nuclear Information System (INIS)

    Bergmann, P.G.


    With the birth of quantum field theory in the late twenties physicists decided that nature could not be half classical and half quantum, and that the gravitational field ought to be quanticized, just as the electromagnetic field had been. One could accept the group of differomorphisms as a fundamental characteristic of general relativity (and indeed of all general-relativistic theories), and proceed to construct a quantum field-theory that was adapted to that group. Quantization would be attempted by way of a Hamiltonian formulation of the (classical) theory, and quantum commutation relations be patterned after the Poisson brackets arising in that formulation. This program is usually called the canonical quantization program, whereas the weak-field approach is known as covariant quantization. The first steps, conceived entirely within the framework of the classical theory, turned out to be beset with technical and conceptual difficulties, which today are essentially resolved. In this paper the author traces out these initial steps

  5. Organizational Culture and Its Implementation in the Choice of Strategic Option - Case Study Montenegro

    Directory of Open Access Journals (Sweden)

    Gordana NIKČEVIĆ


    Full Text Available The topic of this paper is to examine the influence of organizational culture on determination and implementation of the appropriate strategy within the company. Specifically, the author has tested the hypothesis about the influence of organizational culture on determination of strategy in Montenegrin companies. Firstly, in the theoretical part of the paper, the author defined organizational culture and business strategy and then analyzed the nature and manner of influence of organizational culture on formulation and implementation of strategy, as well as influence of implemented strategy on organizational culture. Organizational culture affects formulation of strategy determining information gathering, perception and interpretation of the environment. Namely, culture can facilitate or prevent implementation of the strategy through legitimization process. In the same way, the application of chosen strategy may, through its institutionalization process, reinforce or change the existing organizational culture. The empirical part of the paper refers to research results and testing of hypotheses about the influence of organizational culture on strategy of companies in Montenegro carried out on sample of 16 companies (324 respondents in Montenegro.

  6. Cultural consultation as a model for training multidisciplinary mental healthcare professionals in cultural competence skills: preliminary results. (United States)

    Owiti, J A; Ajaz, A; Ascoli, M; de Jongh, B; Palinski, A; Bhui, K S


    Lack of cultural competence in care contributes to poor experiences and outcomes from care for migrants and racial and ethnic minorities. As a result, health and social care organizations currently promote cultural competence of their workforce as a means of addressing persistent poor experiences and outcomes. At present, there are unsystematic and diverse ways of promoting cultural competence, and their impact on clinician skills and patient outcomes is unknown. We developed and implemented an innovative model, cultural consultation service (CCS), to promote cultural competence of clinicians and directly improve on patient experiences and outcomes from care. CCS model is an adaptation of the McGill model, which uses ethnographic methodology and medical anthropological knowledge. The method and approach not only contributes both to a broader conceptual and dynamic understanding of culture, but also to learning of cultural competence skills by healthcare professionals. The CCS model demonstrates that multidisciplinary workforce can acquire cultural competence skills better through the clinical encounter, as this promotes integration of learning into day-to-day practice. Results indicate that clinicians developed a broader and patient-centred understanding of culture, and gained skills in narrative-based assessment method, management of complexity of care, competing assumptions and expectations, and clinical cultural formulation. Cultural competence is defined as a set of skills, attitudes and practices that enable the healthcare professionals to deliver high-quality interventions to patients from diverse cultural backgrounds. Improving on the cultural competence skills of the workforce has been promoted as a way of reducing ethnic and racial inequalities in service outcomes. Currently, diverse models for training in cultural competence exist, mostly with no evidence of effect. We established an innovative narrative-based cultural consultation service in an inner

  7. Macro-evolutionary studies of cultural diversity: a review of empirical studies of cultural transmission and cultural adaptation. (United States)

    Mace, Ruth; Jordan, Fiona M


    A growing body of theoretical and empirical research has examined cultural transmission and adaptive cultural behaviour at the individual, within-group level. However, relatively few studies have tried to examine proximate transmission or test ultimate adaptive hypotheses about behavioural or cultural diversity at a between-societies macro-level. In both the history of anthropology and in present-day work, a common approach to examining adaptive behaviour at the macro-level has been through correlating various cultural traits with features of ecology. We discuss some difficulties with simple ecological associations, and then review cultural phylogenetic studies that have attempted to go beyond correlations to understand the underlying cultural evolutionary processes. We conclude with an example of a phylogenetically controlled approach to understanding proximate transmission pathways in Austronesian cultural diversity.

  8. Triple co-culture cell model as an in vitro model for oral particulate vaccine systems

    DEFF Research Database (Denmark)

    Nielsen, Line Hagner; De Rossi, C.; Lehr, C.-M.

    the immunostimulatory ability of particulate vaccine formulations designed for oral delivery. Levels of cytokine production in response to vaccine administration were measured following particulate vaccine administration, as an indication of dendritic cell and macrophage activation. Precursors of cubosomes containing......; this was not observed with ovalbumin and blank solution. An example of the results is shown in Figure 2 for IL-17A. An established co-culture of Caco-2, THP-1 and MUTZ-3 cells showed promise as an in vitro model for testing of oral vaccine formulations. Mobility of co-culture immune cells as well as cytokine production...... with particle formulations. This was not the case when incubating with ovalbumin solution or blank. The ELISA screening assay showed production of a wide range of cytokines following culture incubation with cubosomes (with and without ovalbumin) and LPS solutions, indicative of a stimulatory effect...

  9. Occupation, well-being, and culture: Theory and cultural humility. (United States)

    Hammell, Karen R Whalley


    The Canadian Model of Occupational Performance and Engagement depicts individuals embedded within cultural environments that afford occupational possibilities. Culture pertains not solely to ethnicity or race but to any dimension of diversity, including class, gender, sexual orientation, and ability. This paper highlights specific dimensions of cultural diversity and their relationships to occupational engagement and well-being. Cultural variations constitute the basis for a socially constructed hierarchy of traits that significantly determine occupational opportunities and impact mental health and well-being. Cultural humility is an approach to redressing power imbalances in client-therapist relationships by incorporating critical self-evaluation and recognizing that cultural differences lie not within clients but within client-therapist relationships. It is proposed that theoretical relevance would be enhanced if culturally diverse perspectives were incorporated into theories of occupation. Cultural humility is advocated as an approach to theoretical development and in efforts to counter professional Eurocentrism, ethnocentrism, and intellectual colonialism.

  10. The Internalization Theory of Emotions: A Cultural Historical Approach to the Development of Emotions (United States)

    Holodynski, Manfred


    Starting with an overview of theoretical approaches to emotion from an activity-oriented stance, this article applies Vygotsky's three general principles of development, sign mediation, and internalization to the development of emotional expressions as a culturally evolved sign system. The possible twofold function of expression signs as a means…

  11. Cultural pathways through universal development. (United States)

    Greenfield, Patricia M; Keller, Heidi; Fuligni, Andrew; Maynard, Ashley


    We focus our review on three universal tasks of human development: relationship formation, knowledge acquisition, and the balance between autonomy and relatedness at adolescence. We present evidence that each task can be addressed through two deeply different cultural pathways through development: the pathways of independence and interdependence. Whereas core theories in developmental psychology are universalistic in their intentions, they in fact presuppose the independent pathway of development. Because the independent pathway is therefore well-known in psychology, we focus a large part of our review on empirically documenting the alternative, interdependent pathway for each developmental task. We also present three theoretical approaches to culture and development: the ecocultural, the sociohistorical, and the cultural values approach. We argue that an understanding of cultural pathways through human development requires all three approaches. We review evidence linking values (cultural values approach), ecological conditions (ecocultural approach), and socialization practices (sociohistorical approach) to cultural pathways through universal developmental tasks.

  12. Platelet lysate formulations based on mucoadhesive polymers for the treatment of corneal lesions. (United States)

    Sandri, Giuseppina; Bonferoni, Maria Cristina; Rossi, Silvia; Ferrari, Franca; Mori, Michela; Del Fante, Claudia; Perotti, Cesare; Scudeller, Luigia; Caramella, Carla


    Growth factors contained in platelet α-granules initiate and modulate tissue repair and are proposed for the treatment of soft and hard-tissue surgical conditions and in the management of non-healing wounds. Platelet lysate is a hemoderivative obtained from platelet-rich plasma and is capable of releasing a pool of growth factors. Many medical and surgical techniques have been proposed for the treatment of corneal lesions; management of these conditions remains problematic and healing with standard protocols is unattainable. The aim of this study was to develop formulations suitable for prolonging the contact of platelet lysate with the damaged cornea for the time necessary to exert a therapeutic effect. Two vehicles, one based on polyacrylic acid and one based on chitosan, were autoclaved and loaded with platelet lysate and the resultant formulations were characterized for rheology, mucoadhesion, vehicle compatibility and stability. The proliferation effect was tested on two cell culture types (rabbit corneal epithelial cells and fibroblasts). An in-vitro wound-healing test was performed on fibroblasts. In both cases the formulations were compared with platelet lysate diluted with saline at the same concentration. Both formulations maintained the rheological and mucoadhesive properties of the vehicles and the proliferative activity of platelet lysate. The chitosan formulation was able to significantly enhance epithelial cell growth even after storage of up to 2 weeks (in-use conditions), while the polyacrylic acid formulation was less efficient, probably due to the characteristics of the cell model used. The in-vitro wound-healing test performed on fibroblasts confirmed the differences between the two vehicles. The effect induced by the platelet lysate and chitosan formulation was faster than that of the polyacrylic acid formulation and complete in-vitro wound repair was achieved within 48 h. © 2010 The Authors. JPP © 2010 Royal Pharmaceutical Society.

  13. Formulation, stabilisation and encapsulation of bacteriophage for phage therapy. (United States)

    Malik, Danish J; Sokolov, Ilya J; Vinner, Gurinder K; Mancuso, Francesco; Cinquerrui, Salvatore; Vladisavljevic, Goran T; Clokie, Martha R J; Garton, Natalie J; Stapley, Andrew G F; Kirpichnikova, Anna


    Against a backdrop of global antibiotic resistance and increasing awareness of the importance of the human microbiota, there has been resurgent interest in the potential use of bacteriophages for therapeutic purposes, known as phage therapy. A number of phage therapy phase I and II clinical trials have concluded, and shown phages don't present significant adverse safety concerns. These clinical trials used simple phage suspensions without any formulation and phage stability was of secondary concern. Phages have a limited stability in solution, and undergo a significant drop in phage titre during processing and storage which is unacceptable if phages are to become regulated pharmaceuticals, where stable dosage and well defined pharmacokinetics and pharmacodynamics are de rigueur. Animal studies have shown that the efficacy of phage therapy outcomes depend on the phage concentration (i.e. the dose) delivered at the site of infection, and their ability to target and kill bacteria, arresting bacterial growth and clearing the infection. In addition, in vitro and animal studies have shown the importance of using phage cocktails rather than single phage preparations to achieve better therapy outcomes. The in vivo reduction of phage concentration due to interactions with host antibodies or other clearance mechanisms may necessitate repeated dosing of phages, or sustained release approaches. Modelling of phage-bacterium population dynamics reinforces these points. Surprisingly little attention has been devoted to the effect of formulation on phage therapy outcomes, given the need for phage cocktails, where each phage within a cocktail may require significantly different formulation to retain a high enough infective dose. This review firstly looks at the clinical needs and challenges (informed through a review of key animal studies evaluating phage therapy) associated with treatment of acute and chronic infections and the drivers for phage encapsulation. An important driver

  14. Application of the KeratinoSens™ assay for assessing the skin sensitization potential of agrochemical active ingredients and formulations. (United States)

    Settivari, Raja S; Gehen, Sean C; Amado, Ricardo Acosta; Visconti, Nicolo R; Boverhof, Darrell R; Carney, Edward W


    Assessment of skin sensitization potential is an important component of the safety evaluation process for agrochemical products. Recently, non-animal approaches including the KeratinoSens™ assay have been developed for predicting skin sensitization potential. Assessing the utility of the KeratinoSens™ assay for use with multi-component mixtures such as agrochemical formulations has not been previously evaluated and is a significant need. This study was undertaken to evaluate the KeratinoSens™ assay prediction potential for agrochemical formulations. The assay was conducted for 8 agrochemical active ingredients (AIs) including 3 sensitizers (acetochlor, meptyldinocap, triclopyr), 5 non-sensitizers (aminopyralid, clopyralid, florasulam, methoxyfenozide, oxyfluorfen) and 10 formulations for which in vivo sensitization data were available. The KeratinoSens™ correctly predicted the sensitization potential of all the AIs. For agrochemical formulations it was necessary to modify the standard assay procedure whereby the formulation was assumed to have a common molecular weight. The resultant approach correctly predicted the sensitization potential for 3 of 4 sensitizing formulations and all 6 non-sensitizing formulations when compared to in vivo data. Only the meptyldinocap-containing formulation was misclassified, as a result of high cytotoxicity. These results demonstrate the promising utility of the KeratinoSens™ assay for evaluating the skin sensitization potential of agrochemical AIs and formulations. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. What 'cultural' approach of electricity history?

    International Nuclear Information System (INIS)

    Beltran, Alain


    The evolution of electricity consumption should be related to social and cultural change. To understand this change better, we should use the notion of 'mentalities', which is less vague than 'culture' and permits us to include practices in a dynamic totality. It is true that the study of consumers is difficult since they do not appear much in business archives. We must study the literature, advertisement and art of the time. Electricity was given its fairy status by the press. Before 1914, many myths, both frightening and reassuring, circulated around this form of energy. It is only during the Inter-war period that electricity had been degraded from the status of goddess to the one of maid. And yet, it did keep its double aspect of a soft and dangerous form of energy, as shown by its mid-1970's marriage to nuclear energy. A comparative cultural history of electricity remains to be done

  16. Introduction to German Culture: An Interdisciplinary Approach. (United States)

    Roig, Kathleen


    Describes a course, taught in English, entitled "Introduction to German Culture," which was designed to meet the needs of students who have visited or plan to visit Germany and want to take a course in its contemporary culture, politics, and social problems. (SED)

  17. Dissolution rates of over-the-counter painkillers: a comparison among formulations. (United States)

    Alemanni, Matteo; Gatoulis, Sergio C; Voelker, Michael


    We wanted to compare the dissolution profile of several over-the-counter analgesics to understand whether the different formulation techniques employed to enhance absorption were associated with variations in the dissolution rate, a parameter known to affect drug absorption. We considered 5 formulations currently marketed in Italy: aspirin tablets (Aspirina Dolore e Infiammazione®), ibuprofen tablets and liquid capsules (Moment®), ibuprofen lysine tablets (Nurofenimmedia®) and dexketoprofen trometamol tablets (Enantyum®). Dissolution tests were performed according to the current USP/NF monograph dissolution procedure. Drug dissolution was evaluated at 1, 3, 6, 15, and 30 minutes since the start of the test. Dissolution was evaluated at three different pH: 1.2, 4.5 and 6.8. Every test was repeated 12 times. The aspirin formulation was by far the most rapid dissolving formulation, among those tested, with more than 80% of the tablet dissolved at 6 minutes for every pH considered. At pH 1.2 and 4.5, only the dexketoprofen formulation was able to reach the dissolution level of aspirin at 30 minutes, but had lower levels of dissolution at the previous time points. Instead, at pH 6.8, most of the formulations approached aspirin dissolution level, but only after 15 minutes. Ibuprofen capsules had the slowest kinetics, with a lag phase the first 6 minutes. Different formulation strategies can lead to great differences in the dissolution rates even among drugs of the same class, suggesting that enhancements in the formulation of painkillers can lead to improvements in drug absorption, and thus in the onset of analgesia.

  18. Psychiatric Cultures Compared : Psychiatry and Mental Health Care in the Twentieth Century: Comparisons and Approaches

    NARCIS (Netherlands)

    Gijswijt-Hofstra, Marijke; Oosterhuis, Harry; Vijselaar, Joost; Freeman, Hugh


    The history of mental health care in the twentieth century is a relatively uncharted territory. Exemplifying a new emphasis on the comparative approach, this volume offers overviews of various national psychiatric cultures and explores new research subjects. By confronting Dutch psychiatry with

  19. Siting technological risks: cultural approaches and cross-cultural ethics

    NARCIS (Netherlands)

    Basta, C.


    Are European national risk prevention regulations reflecting different cultural attitudes towards risk? This article replies positively to this question by elaborating the results of an investigation led between 2004 and 2008 by the Joint Research Centre of the European Commission. The investigation

  20. Redesigning government regulations towards a tobacco endgame strategy: a comparative law approach

    Directory of Open Access Journals (Sweden)

    Lee Edson Yarcia


    Incorporation of international law in domestic law allows States to formulate tobacco endgame strategies through legislative and/or executive actions. The formulation based on the Philippines could be a basis for other States to formulate their respective end game strategies, taking into consideration their unique political, cultural, economic, and epidemiological contexts.

  1. Constitutional Openness in 1991, Ethnic and Cultural Diversity, and Political System: a Philosophical-Political Approach

    Directory of Open Access Journals (Sweden)

    Nelson Jair Cuchumbé Holguín


    Full Text Available The multicultural approach seems to be the most praiseworthy instrument through which the acknowledgement of cultural diversity could renew the deontic structure legitimised by the socio-political order in Colombia. Facing a State model based on the denial and exclusion of diversity, the multicultural State allows for pluralism to be articulated into it. In this way, the formation of political unity becomes a matter determined by dialogue, mutual acknowledgement and cultural enhancement. Nevertheless, the multicultural interpretation lacks plausibility if the formation of the State is understood in a pragmatic and universalistic way. From this perspective, the inclusion of the Other is likely only if social actors promote interactions regulated by a political culture based on constitutional principles, active participation, public deliberation and the organisational ability of communities. A shared political culture of this nature seems unavoidable if the purpose is to form a citizenship more suited to living in a democracy.

  2. Cultural Adaptation of a Preventive Program for Ultra-Orthodox Preschool Boys (United States)

    Gilboa, Yafit


    Cultural factors significantly influence the effectiveness of pediatric screening that enables the prevention of developmental disturbances. The formulation of intervention programs must match the needs of the child, his or her family, and educators. Recognizing the importance of creating an intervention program accessible to the culture of the…

  3. Formulation of Biocides Increases Antimicrobial Potency and Mitigates the Enrichment of Nonsusceptible Bacteria in Multispecies Biofilms (United States)

    Forbes, Sarah; Cowley, Nicola; Mistry, Hitesh; Amézquita, Alejandro


    ABSTRACT The current investigation aimed to generate data to inform the development of risk assessments of biocide usage. Stabilized domestic drain biofilm microcosms were exposed daily over 6 months to increasing concentrations (0.01% to 1%) of the biocide benzalkonium chloride (BAC) in a simple aqueous solution (BAC-s) or in a complex formulation (BAC-f) representative of a domestic cleaning agent. Biofilms were analyzed by culture, differentiating by bacterial functional group and by BAC or antibiotic susceptibility. Bacterial isolates were identified by 16S rRNA sequencing, and changes in biofilm composition were assessed by high-throughput sequencing. Exposure to BAC-f resulted in significantly larger reductions in levels of viable bacteria than exposure to BAC-s, while bacterial diversity greatly decreased during exposure to both BAC-s and BAC-f, as evidenced by sequencing and viable counts. Increases in the abundance of bacteria exhibiting reduced antibiotic or BAC susceptibility following exposure to BAC at 0.1% were significantly greater for BAC-s than BAC-f. Bacteria with reduced BAC and antibiotic susceptibility were generally suppressed by higher BAC concentrations, and formulation significantly enhanced this effect. Significant decreases in the antimicrobial susceptibility of bacteria isolated from the systems before and after long-term BAC exposure were not detected. In summary, dose-dependent suppression of bacterial viability by BAC was enhanced by formulation. Biocide exposure decreased bacterial diversity and transiently enriched populations of organisms with lower antimicrobial susceptibility, and the effects were subsequently suppressed by exposure to 1% BAC-f, the concentration most closely reflecting deployment in formulated products. IMPORTANCE Assessment of the risks of biocide use has been based mainly on the exposure of axenic cultures of bacteria to biocides in simple aqueous solutions. The current investigation aimed to assess the

  4. Using Social Scientific Criteria to Evaluate Cultural Theories: Encoding/Decoding Evaluated

    Directory of Open Access Journals (Sweden)

    Evan L. Kropp


    Full Text Available This article transcends the issue of conflicting theoretical schools of thought to formulate a method of social scientific style theory evaluation for cultural studies. It is suggested that positivist social scientific models of theory critique can be used to assess cultural models of communication to determine if they should be classified as theories. A set of evaluation criteria is formulated as a guide and applied to Stuart Hall’s Encoding/Decoding to determine if it is a theory. Conclusions find the sharing of criteria between schools of thought is judicious, Encoding/Decoding fits the established criteria, and Encoding/Decoding should be referred to as a theory.

  5. Mass Society/Culture/Media: An Eclectic Approach. (United States)

    Clavner, Jerry B.

    Instructors of courses in mass society, culture, and communication start out facing three types of difficulties: the historical orientation of learning, the parochialism of various disciplines, and negative intellectually elitist attitudes toward mass culture/media. Added to these problems is the fact that many instructors have little or no…

  6. Applications of lipid based formulation technologies in the delivery of biotechnology-based therapeutics. (United States)

    du Plessis, Lissinda H; Marais, Etienne B; Mohammed, Faruq; Kotzé, Awie F


    In the last decades several new biotechnologically-based therapeutics have been developed due to progress in genetic engineering. A growing challenge facing pharmaceutical scientists is formulating these compounds into oral dosage forms with adequate bioavailability. An increasingly popular approach to formulate biotechnology-based therapeutics is the use of lipid based formulation technologies. This review highlights the importance of lipid based drug delivery systems in the formulation of oral biotechnology based therapeutics including peptides, proteins, DNA, siRNA and vaccines. The different production procedures used to achieve high encapsulation efficiencies of the bioactives are discussed, as well as the factors influencing the choice of excipient. Lipid based colloidal drug delivery systems including liposomes and solid lipid nanoparticles are reviewed with a focus on recent advances and updates. We further describe microemulsions and self-emulsifying drug delivery systems and recent findings on bioactive delivery. We conclude the review with a few examples on novel lipid based formulation technologies.

  7. Korean Screen Cultures

    DEFF Research Database (Denmark)

    Screen Cultures sets out to redress this imbalance with a broad selection of essays spanning both North and South as well as different methodological approaches, from ethnographic and audience studies to cultural materialist readings. The first section of the book, «The South», highlights popular media...... new approaches to Korean popular culture beyond national borders and includes work on K-pop and Korean television drama. This book is a vital addition to existing scholarship on Korean popular culture, offering a unique view by providing an imaginary unification of the two Koreas negotiated through...

  8. A multi-disciplinary approach for the structural monitoring of Cultural Heritages in a seismic area (United States)

    Fabrizia Buongiorno, Maria; Musacchio, Massimo; Guerra, Ignazio; Porco, Giacinto; Stramondo, Salvatore; Casula, Giuseppe; Caserta, Arrigo; Speranza, Fabio; Doumaz, Fawzi; Giovanna Bianchi, Maria; Luzi, Guido; Ilaria Pannaccione Apa, Maria; Montuori, Antonio; Gaudiosi, Iolanda; Vecchio, Antonio; Gervasi, Anna; Bonali, Elena; Romano, Dolores; Falcone, Sergio; La Piana, Carmelo


    In the recent years, the concepts of seismic risk vulnerability and structural health monitoring have become very important topics in the field of both structural and civil engineering for the identification of appropriate risk indicators and risk assessment methodologies in Cultural Heritages monitoring. The latter, which includes objects, building and sites with historical, architectural and/or engineering relevance, concerns the management, the preservation and the maintenance of the heritages within their surrounding environmental context, in response to climate changes and natural hazards (e.g. seismic, volcanic, landslides and flooding hazards). Within such a framework, the complexity and the great number of variables to be considered require a multi-disciplinary approach including strategies, methodologies and tools able to provide an effective monitoring of Cultural Heritages form both scientific and operational viewpoints. Based on this rationale, in this study, an advanced, technological and operationally-oriented approach is presented and tested, which enables measuring and monitoring Cultural Heritage conservation state and geophysical/geological setting of the area, in order to mitigate the seismic risk of the historical public goods at different spatial scales*. The integration between classical geophysical methods with new emerging sensing techniques enables a multi-depth, multi-resolution, and multi-scale monitoring in both space and time. An integrated system of methodologies, instrumentation and data-processing approaches for non-destructive Cultural Heritage investigations is proposed, which concerns, in detail, the analysis of seismogenetic sources, the geological-geotechnical setting of the area and site seismic effects evaluation, proximal remote sensing techniques (e.g. terrestrial laser scanner, ground-based radar systems, thermal cameras), high-resolution aerial and satellite-based remote sensing methodologies (e.g. aeromagnetic surveys

  9. Cultural probes

    DEFF Research Database (Denmark)

    Madsen, Jacob Østergaard

    The aim of this study was thus to explore cultural probes (Gaver, Boucher et al. 2004), as a possible methodical approach, supporting knowledge production on situated and contextual aspects of occupation.......The aim of this study was thus to explore cultural probes (Gaver, Boucher et al. 2004), as a possible methodical approach, supporting knowledge production on situated and contextual aspects of occupation....

  10. A comprehensive screening platform for aerosolizable protein formulations for intranasal and pulmonary drug delivery. (United States)

    Röhm, Martina; Carle, Stefan; Maigler, Frank; Flamm, Johannes; Kramer, Viktoria; Mavoungou, Chrystelle; Schmid, Otmar; Schindowski, Katharina


    Aerosolized administration of biopharmaceuticals to the airways is a promising route for nasal and pulmonary drug delivery, but - in contrast to small molecules - little is known about the effects of aerosolization on safety and efficacy of biopharmaceuticals. Proteins are sensitive against aerosolization-associated shear stress. Tailored formulations can shield proteins and enhance permeation, but formulation development requires extensive screening approaches. Thus, the aim of this study was to develop a cell-based in vitro technology platform that includes screening of protein quality after aerosolization and transepithelial permeation. For efficient screening, a previously published aerosolization-surrogate assay was used in a design of experiments approach to screen suitable formulations for an IgG and its antigen-binding fragment (Fab) as exemplary biopharmaceuticals. Efficient, dose-controlled aerosol-cell delivery was performed with the ALICE-CLOUD system containing RPMI 2650 epithelial cells at the air-liquid interface. We could demonstrate that our technology platform allows for rapid and efficient screening of formulations consisting of different excipients (here: arginine, cyclodextrin, polysorbate, sorbitol, and trehalose) to minimize aerosolization-induced protein aggregation and maximize permeation through an in vitro epithelial cell barrier. Formulations reduced aggregation of native Fab and IgG relative to vehicle up to 50% and enhanced transepithelial permeation rate up to 2.8-fold. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

  11. Within- and between-culture variation: individual differences and the cultural logics of honor, face, and dignity cultures. (United States)

    Leung, Angela K-Y; Cohen, Dov


    The CuPS (Culture × Person × Situation) approach attempts to jointly consider culture and individual differences, without treating either as noise and without reducing one to the other. Culture is important because it helps define psychological situations and create meaningful clusters of behavior according to particular logics. Individual differences are important because individuals vary in the extent to which they endorse or reject a culture's ideals. Further, because different cultures are organized by different logics, individual differences mean something different in each. Central to these studies are concepts of honor-related violence and individual worth as being inalienable versus socially conferred. We illustrate our argument with 2 experiments involving participants from honor, face, and dignity cultures. The studies showed that the same "type" of person who was most helpful, honest, and likely to behave with integrity in one culture was the "type" of person least likely to do so in another culture. We discuss how CuPS can provide a rudimentary but integrated approach to understanding both within- and between-culture variation. (c) 2011 APA, all rights reserved

  12. Efficiency of biological activator formulated material (BAFM) for volatile organic compounds removal--preliminary batch culture tests with activated sludge. (United States)

    Corre, Charline; Couriol, Catherine; Amrane, Abdeltif; Dumont, Eric; Andrès, Yves; Le Cloirec, Pierre


    During biological degradation, such as biofiltration of air loaded with volatile organic compounds, the pollutant is passed through a bed packed with a solid medium acting as a biofilm support. To improve microorganism nutritional equilibrium and hence to enhance the purification capacities, a Biological Activator Formulated Material (BAFM) was developed, which is a mixture of solid nutrients dissolving slowly in a liquid phase. This solid was previously validated on mineral pollutants: ammonia and hydrogen sulphide. To evaluate the efficiency of such a material for biodegradation of some organic compounds, a simple experiment using an activated sludge batch reactor was carried out. The pollutants (sodium benzoate, phenol, p-nitrophenol and 2-4-dichlorophenol) were in the concentration range 100 to 1200 mg L(-1). The positive impact of the formulated material was shown. The improvement of the degradation rates was in the range 10-30%. This was the consequence of the low dissolution of the nutrients incorporated during material formulation, followed by their consumption by the biomass, as shown for urea used as a nitrogen source. Owing to its twofold interest (mechanical resistance and nutritional supplementation), the Biological Activator Formulated Material seems to be a promising material. Its addition to organic or inorganic supports should be investigated to confirm its relevance for implementation in biofilters.

  13. Bridging Theory and Practice: Using Hip-Hop Pedagogy As A Culturally Relevant Approach In The Urban Science Classroom (United States)

    Adjapong, Edmund S.

    This dissertation explores the context of urban science education as it relates to the achievement and engagement of urban youth. This study provides a framework for Hip-Hop Pedagogy, an approach to teaching and learning anchored in the creative elements of Hip-Hop culture, in STEM as an innovative approach to teaching and learning demonstrates the effect that Hip-Hop Pedagogy, as a culturally relevant approach to teaching has on teaching and learning in an urban science classroom. This study establishes practical tools and approaches, which were formed from by theory and research that transcend the traditional monolithic approaches to teaching science. Participants in this study are middle school students who attend an urban school in one of the largest school systems in the country. This research showed that as result of utilizing Hip-Hop pedagogical practices, students reported that they developed a deeper understanding of science content, students were more likely to identify as scientists, and students were provided a space and opportunities to deconstruct traditional classroom spaces and structures.

  14. Microcanonical formulation of quantum field theories

    International Nuclear Information System (INIS)

    Iwazaki, A.


    A microcanonical formulation of Euclidean quantum field theories is presented. In the formulation, correlation functions are given by a microcanonical ensemble average of fields. Furthermore, the perturbative equivalence of the formulation and the standard functional formulation is proved and the equipartition low is derived in our formulation. (author)

  15. Use of Cowpea and Pigeon pea as Nutritional Ingredients in Culture ...

    African Journals Online (AJOL)

    Use of Cowpea and Pigeon pea as Nutritional Ingredients in Culture Media. ... Sudan Journal of Medical Sciences ... Cheap, locally available plant seeds such as cowpea (Vigna unguiculata) and pigeon pea (Cajanus cajan) could be used in the design and formulation of microbial culture media in order to reduce the cost.

  16. Approaches to measuring cultural diversity in recreation (United States)

    Chieh-Lu Li; James D. Absher; Yi-Chung Hsu; Alan R. Graefe


    Measuring cultural diversity in recreation has become an important topic because of the increasing coverage of and interest in ethnicity and cross-cultural aspects of recreation. Introducing theories and methods from established disciplines other than leisure studies/recreation and park studies is necessary to understand this important issue. In this article, we first...

  17. Bio-Culturalism

    DEFF Research Database (Denmark)

    Grodal, Torben Kragh


    The article argues on the basis of analyses of successful films for children that not only cultural determinants but also innate determinats are important, and that film studies should combine cultural studies with cognitive theory, evolutionary theory and neuroscience, an approach that is called...... Bio-culturalism....

  18. Reactive decontamination formulation (United States)

    Giletto, Anthony [College Station, TX; White, William [College Station, TX; Cisar, Alan J [Cypress, TX; Hitchens, G Duncan [Bryan, TX; Fyffe, James [Bryan, TX


    The present invention provides a universal decontamination formulation and method for detoxifying chemical warfare agents (CWA's) and biological warfare agents (BWA's) without producing any toxic by-products, as well as, decontaminating surfaces that have come into contact with these agents. The formulation includes a sorbent material or gel, a peroxide source, a peroxide activator, and a compound containing a mixture of KHSO.sub.5, KHSO.sub.4 and K.sub.2 SO.sub.4. The formulation is self-decontaminating and once dried can easily be wiped from the surface being decontaminated. A method for decontaminating a surface exposed to chemical or biological agents is also disclosed.

  19. Communicative Competence Approach to Person-Oriented Teaching of the Russian Language and Culture of Speech

    Directory of Open Access Journals (Sweden)

    Y. V. Orlova


    Full Text Available The paper is devoted to the communicative competence approach in professional training of physicians on the undergraduate level. The main emphasis is on developing linguistic, sociolinguistic and pragmatic competences while teaching the Russian language and the culture of speech. The paper is aimed at analyzing the requirements of federal state educational standards of the 3rd generation concerning the competences in the humanities which should be developed by medical students in the course of the Russian language and the culture of speech; defining the contents of the «communicative competence» term based on consideration of general European competences in mastering the language and the analysis of lingua-didactic works of modern Russian scientists; identifying the component content of linguistic, sociolinguistic and pragmatic competences of the Russian language and the culture of speech course for medical schools. The research results regarding the analysis and component content of linguistic, sociolinguistic and pragmatic competences of the Russian language and the culture of speech course have been applied while designing the Russian and the culture of speech curriculum, as well as electronic textbooks and manuals for medical students. 

  20. Application of fuzzy set theory for safety culture and safety management assessment of Kartini research reactor

    International Nuclear Information System (INIS)

    Syarip; Hauptmanns, U.


    The safety culture status of nuclear power plant is usually assessed through interview and/or discussions with personnel and management in plant, and an assessment of the pertinent documentation. The approach for safety culture assessment described in IAEA Safety Series, make uses of a questionnaire composed of questions which require 'Yes' or 'No' as an answer. Hence, it is basically a check-list approach which is quite common for safety assessments in industry. Such a procedure ignores the fact that the expert answering the question usually has knowledge which goes far beyond a mere binary answer. Additionally, many situations cannot readily be described in such restricted terms. Therefore, it was developed a checklist consisting of questions which are formulated such that they require more than a simple 'yes' or 'no' as an answer. This allows one to exploit the expert knowledge of the analyst appropriately by asking him to qualify the degree of compliance of each of the topics examined. The method presented has proved useful in assessing the safety culture and quality of safety management of the research reactor. The safety culture status and the quality of safety management of Kartini research reactor is rated as 'average'. The method is also flexible and allows one to add questions to existing areas or to introduce new areas covering related topics

  1. Study of energy partitioning using a set of related explosive formulations (United States)

    Lieber, Mark; Foster, Joseph C.; Stewart, D. Scott


    Condensed phase high explosives convert potential energy stored in the electro-magnetic field structure of complex molecules to high power output during the detonation process. Historically, the explosive design problem has focused on intramolecular energy storage. The molecules of interest are derived via molecular synthesis providing near stoichiometric balance on the physical scale of the molecule. This approach provides prompt reactions based on transport physics at the molecular scale. Modern material design has evolved to approaches that employ intermolecular ingredients to alter the spatial and temporal distribution of energy release. State of the art continuum methods have been used to study this approach to the materials design. Cheetah has been used to produce data for a set of fictitious explosive formulations based on C-4 to study the partitioning of the available energy between internal and kinetic energy in the detonation. The equation of state information from Cheetah has been used in ALE3D to develop an understanding of the relationship between variations in the formulation parameters and the internal energy cycle in the products.

  2. Formulation of resveratrol entrapped niosomes for topical use. (United States)

    Pando, Daniel; Matos, María; Gutiérrez, Gemma; Pazos, Carmen


    A new approach to the formulation of resveratrol (RSV) entrapped niosomes for topical use is proposed in this work. Niosomes were formulated with Gelot 64 (G64) as surfactant, and two skin-compatible unsaturated fatty acids (oleic and linoleic acids), commonly used in pharmaceutical formulations, as penetration enhancers. Niosomes were prepared by two different methods: a thin film hydration method with minor modifications followed by a sonication stage (TFH-S), and an ethanol injection modified method (EIM). Niosomes prepared with the EIM method were in the range of 299-402 nm, while the TFH-S method produced larger niosomes in the range of 293-496 nm. Moreover, niosomes with higher RSV entrapment efficiency (EE) and better stability were generated by the EIM method. Ex vivo transdermal experiments, carried out in Franz diffusion cells on newborn pig skin, indicated that niosomes prepared by the EIM method were more effective for RSV penetration in epidermis and dermis (EDD), with values up to 21% for both penetration enhancers tested. The EIM method, which yielded the best RSV-entrapped niosomes, seems to be the most suitable for scaling up. Copyright © 2015 Elsevier B.V. All rights reserved.


    Directory of Open Access Journals (Sweden)

    N. Yu. Kryvda


    Full Text Available Purpose. The article is devoted to the cultural aspect of texts using in European culture. The paper found out methodological basis of correctly interpreting the term "practice" in the philosophical and sociological discourses. In the first case the concept reveals human nature; appealing to the field of ethics and intersubjective interactions. In sociological approach the term practice is contrasted to institutional life. It seems to be an organic; vital relevance of actions for contrast to the mechanically regulated community life. Methodology. The paper considered the typology of human intellectual conditions according to Kant’s divided into pure and practical reason. The last one directs action-willed individual efforts so as to meet the universal relevance and ethical coherence. Gottlieb Fichte interpreted practice reason as the way to combine intellectual intentions and material conditions of human being. G. W. F. Hegel enriched the concept with terms of "objectification" and "alienation” of labour. Karl Marx formulated the main features of activity approach to the human nature exploring. In sociological discourse the term practice is opposed to mechanically done actions (according to institutional normativity. Given the philosophical and sociological methodological contexts the reading is studied as activity that aimed emotional and volitional contact with sense. Originality. The paper analysed the genealogy of reading practices. There were selected two types of text perception – rapid "masculine" and prudent "women's" reading. Women salon environment of the XVIII-th century capitalistic Europe was the main condition for the forming of literary-aware public. The authors analysed the process of reading of the text-as-satisfaction and text-as-pleasure (R. Barthes. The work presents the overview of classical studies of sociocultural field: Thorstein Veblen; Vladimir Toporov; Rolan Barthes and contemporary researchers such as T. Markova

  4. Cultural dissonance among generations: a solution-focused approach with East Asian elders and their families. (United States)

    Lee, Mo Yee; Mjelde-Mossey, LeeAnn


    In traditional East Asian cultures, high value is assigned to family harmony and filial piety coupled with the expectation that elders will be honored and obeyed. A lifetime of such expectations shapes how elders perceive their role and status in the family. Problems can arise when younger, less traditional, generations do not share these expectations. This article describes a solution-focused approach that facilitates the family in creating a beneficial harmony in situations of cultural dissonance. Family members are empowered to draw on personal strengths in which multiple worldviews and values of individual members are recognized, incorporated, and negotiated.

  5. An analytical approach for a nodal formulation of a two-dimensional fixed-source neutron transport problem in heterogeneous medium

    Energy Technology Data Exchange (ETDEWEB)

    Basso Barichello, Liliane; Dias da Cunha, Rudnei [Universidade Federal do Rio Grande do Sul, Porto Alegre, RS (Brazil). Inst. de Matematica; Becker Picoloto, Camila [Universidade Federal do Rio Grande do Sul, Porto Alegre, RS (Brazil). Programa de Pos-Graduacao em Engenharia Mecanica; Tres, Anderson [Universidade Federal do Rio Grande do Sul, Porto Alegre, RS (Brazil). Programa de Pos-Graduacao em Matematica Aplicada


    A nodal formulation of a fixed-source two-dimensional neutron transport problem, in Cartesian geometry, defined in a heterogeneous medium, is solved by an analytical approach. Explicit expressions, in terms of the spatial variables, are derived for averaged fluxes in each region in which the domain is subdivided. The procedure is an extension of an analytical discrete ordinates method, the ADO method, for the solution of the two-dimensional homogeneous medium case. The scheme is developed from the discrete ordinates version of the two-dimensional transport equation along with the level symmetric quadrature scheme. As usual for nodal schemes, relations between the averaged fluxes and the unknown angular fluxes at the contours are introduced as auxiliary equations. Numerical results are in agreement with results available in the literature.

  6. Institutional statism: an overview of the formulation of the taxi recapitalisation policy

    Directory of Open Access Journals (Sweden)

    D. van Schalkwyk


    Full Text Available This article provides an overview of the government’s formulation of the taxi recapitalisation policy which is aimed at regulating the minibus taxi industry. Coupled with a brief social and politico-historical context of the policy, the aim is to highlight the government’s statist conduct in the formulation of the recapitalisation policy. The minibus taxi industry started to fulfil a prominent role in the 1970s as a result of a loophole in the legislation of the former apartheid government. It is currently the most accessible mode of public transport and conveys 65 per cent of the country’s commuters daily. Consequently, the Industry is an imperative force to be considered by the government in its formulation of transport policies. However, the industry is characterised by numerous problems, including a high rate of minibus taxis involved in accidents, unroadworthy vehicles and violence. It is in this context that the government formulated both the original and revised versions of the recapitalisation policy. However, the formulation of the policy has been problematic. The government followed a statist approach during the formulation process when it directed the course of the process according to its interests and without adequate consultation with relevant role players.

  7. The Reaffirmation of Cultural Identity in Cross-cultural Encounters. (United States)

    Kosmitzki, Corinne


    Examines the relationship between cultural contact and cultural identity as conceptualized in two research approaches: social identity theory and acculturation. The groups studied were German and Americans who either lived in their nonnative culture or had no direct contact. Comparisons between bicultural and monocultural groups revealed a…

  8. A Cultural Evolution Approach to Digital Media. (United States)

    Acerbi, Alberto


    Digital media have today an enormous diffusion, and their influence on the behavior of a vast part of the human population can hardly be underestimated. In this review I propose that cultural evolution theory, including both a sophisticated view of human behavior and a methodological attitude to modeling and quantitative analysis, provides a useful framework to study the effects and the developments of media in the digital age. I will first give a general presentation of the cultural evolution framework, and I will then introduce this more specific research program with two illustrative topics. The first topic concerns how cultural transmission biases, that is, simple heuristics such as "copy prestigious individuals" or "copy the majority," operate in the novel context of digital media. The existence of transmission biases is generally justified with their adaptivity in small-scale societies. How do they operate in an environment where, for example, prestigious individuals possess not-relevant skills, or popularity is explicitly quantified and advertised? The second aspect relates to fidelity of cultural transmission. Digitally-mediated interactions support cheap and immediate high-fidelity transmission, in opposition, for example, to oral traditions. How does this change the content that is more likely to spread? Overall, I suggest the usefulness of a "long view" to our contemporary digital environment, contextualized in cognitive science and cultural evolution theory, and I discuss how this perspective could help us to understand what is genuinely new and what is not.

  9. A cultural evolution approach to digital media

    Directory of Open Access Journals (Sweden)

    Alberto Acerbi


    Full Text Available Digital media have today an enormous diffusion, and their influence on the behaviour of a vast part of the human population can hardly be underestimated. In this review I propose that cultural evolution theory, including both a sophisticated view of human behaviour and a methodological attitude to modelling and quantitative analysis, provides a useful framework to study the effects and the developments of media in the digital age. I will first give a general presentation of the cultural evolution framework, and I will then introduce this more specific research program with two illustrative topics.The first topic concerns how cultural transmission biases, that is, simple heuristics such as copy prestigious individuals or copy the majority, operate in the novel context of digital media. The existence of transmission biases is generally justified with their adaptivity in small-scale societies. How do they operate in an environment where, for example, prestigious individuals possess not-relevant skills, or popularity is explicitly quantified and advertised?The second aspect relates to fidelity of cultural transmission. Digitally-mediated interactions support cheap and immediate high-fidelity transmission, in opposition, for example, to oral traditions. How does this change the content that is more likely to spread? Overall, I suggest the usefulness of a long view to our contemporary digital environment, contextualised in cognitive science and cultural evolution theory, and I discuss how this perspective could help us to understand what is genuinely new and what is not.

  10. A Cultural Evolution Approach to Digital Media (United States)

    Acerbi, Alberto


    Digital media have today an enormous diffusion, and their influence on the behavior of a vast part of the human population can hardly be underestimated. In this review I propose that cultural evolution theory, including both a sophisticated view of human behavior and a methodological attitude to modeling and quantitative analysis, provides a useful framework to study the effects and the developments of media in the digital age. I will first give a general presentation of the cultural evolution framework, and I will then introduce this more specific research program with two illustrative topics. The first topic concerns how cultural transmission biases, that is, simple heuristics such as “copy prestigious individuals” or “copy the majority,” operate in the novel context of digital media. The existence of transmission biases is generally justified with their adaptivity in small-scale societies. How do they operate in an environment where, for example, prestigious individuals possess not-relevant skills, or popularity is explicitly quantified and advertised? The second aspect relates to fidelity of cultural transmission. Digitally-mediated interactions support cheap and immediate high-fidelity transmission, in opposition, for example, to oral traditions. How does this change the content that is more likely to spread? Overall, I suggest the usefulness of a “long view” to our contemporary digital environment, contextualized in cognitive science and cultural evolution theory, and I discuss how this perspective could help us to understand what is genuinely new and what is not. PMID:28018200

  11. Applications of an alternative formulation for one-layer real time optimization

    Directory of Open Access Journals (Sweden)

    Schiavon Júnior A.L.


    Full Text Available This paper presents two applications of an alternative formulation for one-layer real time structure for control and optimization. This new formulation have arisen from predictive controller QDMC (Quadratic Dynamic Matrix Control, a type of predictive control (Model Predictive Control - MPC. At each sampling time, the values of the outputs of process are fed into the optimization-control structure which supplies the new values of the manipulated variables already considering the best conditions of process. The variables of optimization are both set-point changes and control actions. The future stationary outputs and the future stationary control actions have both a different formulation of conventional one-layer structure and they are calculated from the inverse gain matrix of the process. This alternative formulation generates a convex problem, which can be solved by less sophisticated optimization algorithms. Linear and nonlinear economic objective functions were considered. The proposed approach was applied to two linear models, one SISO (single-input/single output and the other MIMO (multiple-input/multiple-output. The results showed an excellent performance.

  12. The Pedagogy of Education Policy Formulation: Working from Policy Assets (United States)

    Sack, Richard; Marope, Mmantsetsa


    This article explores a "pedagogical" approach to education policy formulation in developing countries. This constitutes a process that shows promise in promoting the "ownership" necessary for sustainable policies and programs, especially when they rely on external financing. Based on case studies from 26 countries focused on "what works," the…

  13. STRATEGIC HUMAN RESOURCE MANAGEMENT : A Cross-Cultural Managerial Approach


    Anyangwe, Xavier


    The goal of the thesis was to examine the impact of the concepts of culture, human resource management and strategic human resource management. A man without a culture is like a man with no identity, so the identity of people needs to be identified for effective unity in diversity. The findings of the thesis show that cultural diversity is an inclusive aspect of almost all communities and countries in the world. The richness of these cultures in terms of cultural values, languages, intera...

  14. From Cultural Knowledge to Intercultural Communicative Competence: Changing Perspectives on the Role of Culture in Foreign Language Teaching (United States)

    Piatkowska, Katarzyna


    Approaches to the concept of culture and teaching cultural competence in a foreign language classroom have been changing over the last decades. The paper summarises, compares, contrasts and evaluates four major approaches to teaching cultural competence in foreign language teaching, that is, knowledge-based approach, contrastive approach,…


    Directory of Open Access Journals (Sweden)

    Elkonin L.A.


    Full Text Available Genetic transformation is a powerful tool for genetic improvement of arable crops. Genetic engineering approaches are especially important for modification of starch and protein contents, vitamin and micronutrient concentration, improvement of nutritive value of protein fractions, and increase tolerance to environmental stresses. Application of transgenic technologies for genetic improvement of sorghum, a highly productive heat tolerant and drought resistant crop, is extremely important since climate aridization in many regions all over the globe hampers sustainable production of traditional cereals, such as wheat, maize and barley. However, sorghum, in spite of great number of investigations, is one of the most recalcitrant crop species to genetic modification. The most frequently reported problems are a low frequency of transformation and silencing of transgenes. Using the A. tumefaciens strain AGL0/p35SGIB with the bar and gus-intron genes under the nos and CaMV35S promoters, respectively, we studied different methods of Agrobacterium-mediated genetic transformation of the grain sorghum: in vitro culture-based techniques, by inoculation of immature embryos or embryo-derived calli, and pollen-mediated approach, by inoculation of flowering panicles. Four lines of grain sorghum – Milo-10, [9E] Milo-10 (CMS-line, KVV-114, and KVV-45 – were used. In both approaches, for activation of vir-genes agrobacterial cell suspension was grown in the AB or modified AB media with acetosyringone at room temperature. In vitro culture approach was effective for obtaining transgenic plants in the lines Milo-10 and KVV-45, which were able to produce embryogenic callus from immature embryos after their co-cultivation with agrobacterial cell suspension. Callus cultures tolerant to glufosinate ammonium (GA and capable to plant regeneration were obtained. The frequency of immature embryos producing PCR-positive transgenic plants varied in different experiments

  16. Extensive preclinical investigation of polymersomal formulation of doxorubicin versus Doxil-mimic formulation. (United States)

    Alibolandi, Mona; Abnous, Khalil; Mohammadi, Marzieh; Hadizadeh, Farzin; Sadeghi, Fatemeh; Taghavi, Sahar; Jaafari, Mahmoud Reza; Ramezani, Mohammad


    Due to the severe cardiotoxicity of doxorubicin, its usage is limited. This shortcoming could be overcome by modifying pharmacokinetics of the drugs via preparation of various nanoplatforms. Doxil, a well-known FDA-approved nanoplatform of doxorubicin as antineoplastic agent, is frequently used in clinics in order to reduce cardiotoxicity of doxorubicin. Since Doxil shows some shortcomings in clinics including hand and food syndrome and very slow release pattern thus, there is a demand for the development and preparation of new doxorubicin nanoformulation with fewer side effects. The new formulation of the doxorubicin, synthesized previously by our group was extensively examined in the current study. This new formulation is doxorubicin encapsulated in PEG-PLGA polymersomes (PolyDOX). The main aim of the study was to compare the distribution and treatment efficacy of a new doxorubicin-polymersomal formulation (PolyDOX) with regular liposomal formulation (Doxil-mimic) in murine colon adenocarcinoma model. Additionally, the pathological, hematological changes, pharmacodynamics, biodistribution, tolerated dose and survival rate in vivo were evaluated and compared. Murine colon cancer model was induced by subcutaneous inoculation of BALB/c mice with C26 cells. Afterwards, either Doxil-mimic or PolyDOX was administered intravenously. The obtained results from biodistribution study showed a remarkable difference in the distribution of drugs in murine organs. In this regard, Doxil-mimic exhibited prolonged (48h) presence within liver tissues while PolyDOX preferentially accumulate in tumor and the presence in liver 48h post-treatment was significantly lower than that of Doxil-mimic. Obtained results demonstrated comparable final length of life for mice receiving either Doxil-mimic or PolyDOX formulations whereas tolerated dose of mice receiving Doxil-mimic was remarkably higher than those receiving PolyDOX. Therapeutic efficacy of formulation in term of tumor growth rate

  17. Numerical integration of some new unified plasticity-creep formulations

    International Nuclear Information System (INIS)

    Krieg, R.D.


    The usual constitutive description of metals at high temperature treats creep as a phenomenon which must be added to time independent phenomena. A new approach is now being advocated by some people, principally metallurgists. They all treat the inelastic strain as a unified quantity, incapable of being separated into time dependent and time independent parts. This paper examines the behavior of the differential formulations reported in the literature together with one proposed by the author. These formulations are capable of representing primary and secondary creep, cyclic hardening to a stable cyclic stress-strain loop, a conventional plasticity behavior, and a Bauchinger effect which may be creep induced and discernable either at fast or slow loading rates. The new unified formulations seem to lead to very non-linear systems of equations which are very well behaved in some regions and very stiff in other regions where the word 'stiff' is used in the mathematical sense. Simple conventional methods of integrating incremental constitutive equations are observed to be totally inadequate. A method of numerically integrating the equations is presented. (Auth.)

  18. Lagrangian formulation of the general relativistic Poynting-Robertson effect (United States)

    De Falco, Vittorio; Battista, Emmanuele; Falanga, Maurizio


    We propose the Lagrangian formulation for describing the motion of a test particle in a general relativistic, stationary, and axially symmetric spacetime. The test particle is also affected by a radiation field, modeled as a coherent flux of photons traveling along the null geodesics of the background spacetime, including the general relativistic Poynting-Robertson effect. The innovative part of this work is to prove the existence of the potential linked to the dissipative action caused by the Poynting-Robertson effect in general relativity through the help of an integrating factor, depending on the energy of the system. Generally, such kinds of inverse problems involving dissipative effects might not admit a Lagrangian formulation; especially, in general relativity, there are no examples of such attempts in the literature so far. We reduce this general relativistic Lagrangian formulation to the classic case in the weak-field limit. This approach facilitates further studies in improving the treatment of the radiation field, and it contains, for example, some implications for a deeper comprehension of the gravitational waves.

  19. Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies. (United States)

    Kumru, Ozan S; Joshi, Sangeeta B; Smith, Dawn E; Middaugh, C Russell; Prusik, Ted; Volkin, David B


    Instability of vaccines often emerges as a key challenge during clinical development (lab to clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious vaccine dosage forms for human use, successful formulation strategies must address a combination of interrelated topics including stabilization of antigens, selection of appropriate adjuvants, and development of stability-indicating analytical methods. This review covers key concepts in understanding the causes and mechanisms of vaccine instability including (1) the complex and delicate nature of antigen structures (e.g., viruses, proteins, carbohydrates, protein-carbohydrate conjugates, etc.), (2) use of adjuvants to further enhance immune responses, (3) development of physicochemical and biological assays to assess vaccine integrity and potency, and (4) stabilization strategies to protect vaccine antigens and adjuvants (and their interactions) during storage. Despite these challenges, vaccines can usually be sufficiently stabilized for use as medicines through a combination of formulation approaches combined with maintenance of an efficient cold chain (manufacturing, distribution, storage and administration). Several illustrative case studies are described regarding mechanisms of vaccine instability along with formulation approaches for stabilization within the vaccine cold chain. These include live, attenuated (measles, polio) and inactivated (influenza, polio) viral vaccines as well as recombinant protein (hepatitis B) vaccines. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  20. Reducing unnecessary culturing: a systems approach to evaluating urine culture ordering and collection practices among nurses in two acute care settings

    Directory of Open Access Journals (Sweden)

    Robert Redwood


    Full Text Available Abstract Background Inappropriate ordering and acquisition of urine cultures leads to unnecessary treatment of asymptomatic bacteriuria (ASB. Treatment of ASB contributes to antimicrobial resistance particularly among hospital-acquired organisms. Our objective was to investigate urine culture ordering and collection practices among nurses to identify key system-level and human factor barriers and facilitators that affect optimal ordering and collection practices. Methods We conducted two focus groups, one with ED nurses and the other with ICU nurses. Questions were developed using the Systems Engineering Initiative for Patient Safety (SEIPS framework. We used iterative categorization (directed content analysis followed by summative content analysis to code and analyze the data both deductively (using SEIPS domains and inductively (emerging themes. Results Factors affecting optimal urine ordering and collection included barriers at the person, process, and task levels. For ED nurses, barriers included patient factors, physician communication, reflex culture protocols, the electronic health record, urinary symptoms, and ED throughput. For ICU nurses, barriers included physician notification of urinalysis results, personal protective equipment, collection technique, patient body habitus, and Foley catheter issues. Conclusions We identified multiple potential process barriers to nurse adherence with evidence-based recommendations for ordering and collecting urine cultures in the ICU and ED. A systems approach to identifying barriers and facilitators can be useful to design interventions for improving urine ordering and collection practices.

  1. Product Design – From Molecules to Formulations to Devices

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Ng, Ka M.


    Product design is a multidisciplinary and diverse subject. This article focuses on product conceptualization (what-to-make) and briefly reviews the corresponding manufacturing processes (how-to-make). Four product types are considered – molecular products, formulated products, devices...... and functional products. For molecular products, computer-aided design tools are used to predict the physicochemical properties of single molecules and blends. For formulated products, an integrated experiment-molecular modelling approach to generate the formula with the specified product attributes is followed....... For devices and functional products, conceptual product design is carried out by modelling the product based on thermodynamics, kinetics and transport processes, by performing experiments, and by decision making based on experience. The results are product specifications in terms of the type of ingredients...

  2. Product design - Molecules, devices, functional products, and formulated products

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Ng, Ka M.


    Chemical product design is a multidisciplinary and diverse subject. This article provides an overview of product design while focusing on product conceptualization. Four product types are considered - molecular products, formulated products, devices and functional products. For molecular products......, computer-aided design tools are used to predict the physicochemical properties of single molecules and blends. For formulated products, an integrated experiment-modeling approach is used to generate the formula with the specified product attributes. For devices and functional products, conceptual product...... design is carried out by modeling the product based on thermodynamics, kinetics and transport processes, by performing experiments, and by decision making based on rule-based methods The results are product specifications in terms of the type of ingredients, composition, and the structure, form, shape...

  3. High-Level Waste Glass Formulation Model Sensitivity Study 2009 Glass Formulation Model Versus 1996 Glass Formulation Model

    International Nuclear Information System (INIS)

    Belsher, J.D.; Meinert, F.L.


    This document presents the differences between two HLW glass formulation models (GFM): The 1996 GFM and 2009 GFM. A glass formulation model is a collection of glass property correlations and associated limits, as well as model validity and solubility constraints; it uses the pretreated HLW feed composition to predict the amount and composition of glass forming additives necessary to produce acceptable HLW glass. The 2009 GFM presented in this report was constructed as a nonlinear optimization calculation based on updated glass property data and solubility limits described in PNNL-18501 (2009). Key mission drivers such as the total mass of HLW glass and waste oxide loading are compared between the two glass formulation models. In addition, a sensitivity study was performed within the 2009 GFM to determine the effect of relaxing various constraints on the predicted mass of the HLW glass.

  4. Risk based In Vitro Performance Assessment of Extended Release Abuse Deterrent Formulations (United States)

    Xu, Xiaoming; Gupta, Abhay; Al-Ghabeish, Manar; Calderon, Silvia N.; Khan, Mansoor A.


    High strength extended release opioid products, which are indispensable tools in the management of pain, are associated with serious risks of unintentional and potentially fatal overdose, as well as of misuse and abuse that might lead to addiction. The issue of drug abuse becomes increasingly prominent when the dosage forms can be readily manipulated to release a high amount of opioid or to extract the drug in certain products or solvents. One approach to deter opioid drug abuse is by providing novel abuse deterrent formulations (ADF), with properties that may be viewed as barriers to abuse of the product. However, unlike regular extended release formulations, assessment of ADF technologies are challenging, in part due to the great variety of formulation designs available to achieve deterrence of abuse by oral, parenteral, nasal and respiratory routes. With limited prior history or literature information, and lack of compendial standards, evaluation and regulatory approval of these novel drug products become increasingly difficult. The present article describes a risk-based standardized in-vitro approach that can be utilized in general evaluation of abuse deterrent features for all ADF products. PMID:26784976

  5. Flame acceleration due to wall friction: Accuracy and intrinsic limitations of the formulations (United States)

    Demirgok, Berk; Sezer, Hayri; Akkerman, V.'Yacheslav


    The analytical formulations on the premixed flame acceleration induced by wall friction in two-dimensional (2D) channels [Bychkov et al., Phys. Rev. E 72 (2005) 046307] and cylindrical tubes [Akkerman et al., Combust. Flame 145 (2006) 206] are revisited. Specifically, pipes with one end closed are considered, with a flame front propagating from the closed pipe end to the open one. The original studies provide the analytical formulas for the basic flame and fluid characteristics such as the flame acceleration rate, the flame shape and its propagation speed, as well as the flame-generated flow velocity profile. In the present work, the accuracy of these approaches is verified, computationally, and the intrinsic limitations and validity domains of the formulations are identified. Specifically, the error diagrams are presented to demonstrate how the accuracy of the formulations depends on the thermal expansion in the combustion process and the Reynolds number associated with the flame propagation. It is shown that the 2D theory is accurate enough for a wide range of parameters. In contrast, the zeroth-order approximation for the cylindrical configuration appeared to be quite inaccurate and had to be revisited. It is subsequently demonstrated that the first-order approximation for the cylindrical geometry is very accurate for realistically large thermal expansions and Reynolds numbers. Consequently, unlike the zeroth-order approach, the first-order formulation can constitute a backbone for the comprehensive theory of the flame acceleration and detonation initiation in cylindrical tubes. Cumulatively, the accuracy of the formulations deteriorates with the reduction of the Reynolds number and thermal expansion.

  6. Variational formulation and projectional methods for the second order transport equation

    International Nuclear Information System (INIS)

    Borysiewicz, M.; Stankiewicz, R.


    Herein the variational problem for a second-order boundary value problem for the neutron transport equation is formulated. The projectional methods solving the problem are examined. The approach is compared with that based on the original untransformed form of the neutron transport equation

  7. The representation of nurses in 1950s melodrama: a cross-cultural approach. (United States)

    Babini, Elisabetta


    Melodrama is identified as one of the most prolific cinematic genres in terms of the representation of nurses. Its contribution to the overall media depiction of the professional category has therefore been significant. This paper explores melodramatic portrayals of nurses with a specific focus on cinema of the 1950s, the golden age of Western melodrama, and concentrates on two representative case studies: Anna (ITA, 1951), and The Nun's Story (USA, 1959). These films enable a fruitful comparison, sharing several narrative elements, featuring religious nurses as protagonists, and yet eventually conferring on the nursing vocation different values. Such similar nurses' images are examined through a multidisciplinary approach, spanning feminist film theory, gender and cultural studies, cultural history and the social history of nursing. Among the goals of this study is to consider whether different national origins--in these films, Italy and America--have also been influential in the depiction of the respective nurse-character. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Contemporary Approaches to Safety Culture: Lessons from Developing a Regulatory Oversight Approach

    International Nuclear Information System (INIS)

    Goebel, V.; Heppell-Masys, K.


    The Canadian Nuclear Safety Commission (CNSC) regulates the use of nuclear energy and materials to protect health, safety, security and the environment, and to implement Canada’s international commitments on the peaceful use of nuclear energy; and to disseminate objective scientific, technical and regulatory information to the public. In the late 1990s, the CNSC conducted research into an Organization and Management (O&M) assessment method. Based on this research the CNSC conducted O&M assessments at all Canadian nuclear power plants and conducted additional assessments of nuclear research and uranium mine and mill operations. The results of these assessments were presented to licencees and used to inform their ongoing actions related to safety culture. Additional safety culture outreach and oversight activities provided licencees with opportunities to develop effective safety culture assessment methods, to share best practices across industry, and to strive for continual improvement of their organizations. Recent changes to the Canadian Standards Association (CSA) management system standard have resulted in the inclusion of requirements associated to safety culture and human performance. Representatives from several sectors of Canada’s nuclear industry, as well as participation from regulators such as the CNSC took part to the development of this consensus standard. Specifically, these requirements focus on monitoring and understanding safety culture, integrating safety into all of the requirements of the management system, committing workers to adhere to the management system and supporting excellence in workers’ performance. The CNSC is currently developing a regulatory document on safety culture which includes key concepts applicable to all licencees and specific requirements related to self-assessment, and additional guidance for nuclear power plants. Developing a regulatory document on safety culture requires consultation and fact finding initiatives at

  9. Cross-Cultural Effects of Cannabis Use Disorder: Evidence to Support a Cultural Neuroscience Approach. (United States)

    Prashad, Shikha; Milligan, Amber L; Cousijn, Janna; Filbey, Francesca M


    Cannabis use disorders (CUDs) are prevalent worldwide. Current epidemiological studies underscore differences in behaviors that contribute to cannabis use across cultures that can be leveraged towards prevention and treatment of CUDs. This review proposes a framework for understanding the effects of cross-cultural differences on psychological, neural, and genomic processes underlying CUDs that has the potential to inform global policies and impact global public health. We found that cultural factors may influence (1) the willingness to acknowledge CUD-related symptoms among populations of different countries, and (2) neural responses related to the sense of self, perception, emotion, and attention. These findings leverage the potential effects of culture on neural mechanisms underlying CUDs. As the number of individuals seeking treatment for CUDs increases globally, it is imperative to incorporate cultural considerations to better understand and serve differing populations and develop more targeted treatment strategies and interventions.

  10. Lipid Based Formulations of Biopharmaceutics Classification System (BCS Class II Drugs: Strategy, Formulations, Methods and Saturation

    Directory of Open Access Journals (Sweden)

    Šoltýsová I.


    Full Text Available Active ingredients in pharmaceuticals differ by their physico-chemical properties and their bioavailability therefore varies. The most frequently used and most convenient way of administration of medicines is oral, however many drugs are little soluble in water. Thus they are not sufficiently effective and suitable for such administration. For this reason a system of lipid based formulations (LBF was developed. Series of formulations were prepared and tested in water and biorelevant media. On the basis of selection criteria, there were selected formulations with the best emulsification potential, good dispersion in the environment and physical stability. Samples of structurally different drugs included in the Class II of the Biopharmaceutics classification system (BCS were obtained, namely Griseofulvin, Glibenclamide, Carbamazepine, Haloperidol, Itraconazol, Triclosan, Praziquantel and Rifaximin, for testing of maximal saturation in formulations prepared from commercially available excipients. Methods were developed for preparation of formulations, observation of emulsification and its description, determination of maximum solubility of drug samples in the respective formulation and subsequent analysis. Saturation of formulations with drugs showed that formulations 80 % XA and 20 % Xh, 35 % XF and 65 % Xh were best able to dissolve the drugs which supports the hypothesis that it is desirable to identify limited series of formulations which could be generally applied for this purpose.

  11. Introduction. History, Culture and Modernity in China

    Directory of Open Access Journals (Sweden)

    Gotelind Müller


    Full Text Available The article provides a short introduction to the main topics and aims of this thematic issue on history, culture and modernity in China. It outlines the multi-faceted approaches to a (or more than one modernity between and beyond Westernisation and Sinicisation as formulated in the twentieth century, be it in Republican China, Taiwan or the People's Republic, and how this is reflected in "Western" historiography on China. For China, (rearticulations of "alternatives" would open up the possibility for more than just one single, homogenising, culturalist-essentialist (and top-down defined "Chinese dream". Since discussions of modernity are always closely linked to the concerns of the present, shifts in global economy and politics might, in turn, also lead to new conceptions of what a "global modernity" (if such a single entity exists should mean and how the Chinese case might relate (or contribute to it.

  12. The Culure Assimilator: An Approach to Cross-Cultural Training (United States)

    Fiedler, Fred E.; And Others


    Evaluates the cultural assimilator, a kind of training manual to help members of one culture understand and adjust to another culture. Describes those constructed for the Arab countries, Iran, Thailand, Central America, and Greece. (MB)

  13. Meanings of Care: A Culture-Centered Approach to Left-Behind Family Members in the Countryside of China. (United States)

    Sun, Kang; Dutta, Mohan J


    Critical studies of health communication foreground the importance of meanings as organizing frameworks for constituting health. The contested and contradictory meanings articulated around health offer insights into the constraining and enabling roles of structures. Through ethnographic fieldwork conducted in a village in China embedded within the activist framework of the culture-centered approach, this project explores understandings of family care amid left-behind families in rural China against the backdrop of the migration of the middle generation of working adults from families located in rural contexts to cities. We work with the culture-centered approach to explore local meanings of care, understanding everyday care as integral to the health of an aging population that has been erased from the discursive space by market reforms and the hegemonic narrative of national development in China.

  14. Bridging Theory and Practice: Using Hip-Hop Pedagogy as a Culturally Relevant Approach in the Urban Science Classroom (United States)

    Adjapong, Edmund S.


    This dissertation explores the context of urban science education as it relates to the achievement and engagement of urban youth. This study provides a framework for Hip-Hop Pedagogy, an approach to teaching and learning anchored in the creative elements of Hip-Hop culture, in STEM as an innovative approach to teaching and learning demonstrates…

  15. A theoretical and empirical framework for constructing culture-specific stigma instruments for Chile


    Yang,Lawrence H.; Valencia,Elie; Alvarado,Ruben; Link,Bruce; Huynh,Nina; Nguyen,Kristy; Morita,Kara; Saavedra,Mariella; Wong,Chak; Galea,Sandro; Susser,Ezra


    Different cultural contexts contribute to substantial variation in the stigma faced by people with psychosis globally. We propose a new formulation of how culture affects stigma to create psychometrically-validated tools to assess stigma’s culture-specific effects. We propose to construct culture-specific stigma measures for the Chilean context via: 1) open-ended administration of ‘universal’ stigma scales to a sample of individuals with psychosis, relatives, and community respondents; 2) qua...

  16. Persistence of two neem formulations on peach leaves and fruit: effect of the distribution. (United States)

    Sarais, Giorgia; Angioni, Alberto; Lai, Francesco; Cabras, Paolo; Caboni, Pierluigi


    Persistence of azadirachtins (A+B) and of the other limonoids (nimbin, salannin, deacetylnimbin, and deacetylsalannin) on peach leaves and fruits was studied using a commercial formulation (form. C) compared with an experimental formulation (form. E) prepared with coformulations allowed in organic culture. Field experiments were carried out using three concentrations: 1x, 5x, and 10x the dose recommended by the manufacturer. The EU maximum residue level (MRL) in fruits and vegetables for azadirachtin A is 1 mg/kg with a preharvest interval (PHI) of 3 days. At the recommended dose, azadirachtin A residue on fruits was not detectable (LOQ stability. This is probably due to the amount of the active ingredients that diffuse into the epicuticular wax layer thus enhancing photostability of azadirachtoids.

  17. Cross-Cultural Effects of Cannabis Use Disorder: Evidence to Support a Cultural Neuroscience Approach (United States)

    Prashad, Shikha; Milligan, Amber L.; Cousijn, Janna; Filbey, Francesca M.


    Purpose of review Cannabis use disorders (CUDs) are prevalent worldwide. Current epidemiological studies underscore differences in behaviors that contribute to cannabis use across cultures that can be leveraged towards prevention and treatment of CUDs. This review proposes a framework for understanding the effects of cross-cultural differences on psychological, neural, and genomic processes underlying CUDs that has the potential to inform global policies and impact global public health. Recent findings We found that cultural factors may influence (1) the willingness to acknowledge CUD-related symptoms among populations of different countries, and (2) neural responses related to the sense of self, perception, emotion, and attention. These findings leverage the potential effects of culture on neural mechanisms underlying CUDs. Summary As the number of individuals seeking treatment for CUDs increases globally, it is imperative to incorporate cultural considerations to better understand and serve differing populations and develop more targeted treatment strategies and interventions. PMID:29062679

  18. Problem formulation for risk assessment of combined exposures to chemicals and other stressors in humans. (United States)

    Solomon, Keith R; Wilks, Martin F; Bachman, Ammie; Boobis, Alan; Moretto, Angelo; Pastoor, Timothy P; Phillips, Richard; Embry, Michelle R


    When the human health risk assessment/risk management paradigm was developed, it did not explicitly include a "problem formulation" phase. The concept of problem formulation was first introduced in the context of ecological risk assessment (ERA) for the pragmatic reason to constrain and focus ERAs on the key questions. However, this need also exists for human health risk assessment, particularly for cumulative risk assessment (CRA), because of its complexity. CRA encompasses the combined threats to health from exposure via all relevant routes to multiple stressors, including biological, chemical, physical and psychosocial stressors. As part of the HESI Risk Assessment in the 21st Century (RISK21) Project, a framework for CRA was developed in which problem formulation plays a critical role. The focus of this effort is primarily on a chemical CRA (i.e., two or more chemicals) with subsequent consideration of non-chemical stressors, defined as "modulating factors" (ModFs). Problem formulation is a systematic approach that identifies all factors critical to a specific risk assessment and considers the purpose of the assessment, scope and depth of the necessary analysis, analytical approach, available resources and outcomes, and overall risk management goal. There are numerous considerations that are specific to multiple stressors, and proper problem formulation can help to focus a CRA to the key factors in order to optimize resources. As part of the problem formulation, conceptual models for exposures and responses can be developed that address these factors, such as temporal relationships between stressors and consideration of the appropriate ModFs.


    Directory of Open Access Journals (Sweden)

    Saifuddin Dhuhri


    Full Text Available This article elucidates local theology, which encapsulates in the work of shari’a in Acehnese contexts. The argument of this article is grounded in the Acehnese historical epochs in which Acehnese cultural identity were formulated. I argue that Acehnese shari’a is the set of local rituals, beliefs and ideas as the production of local interpretation of Islam, which responds to local cultural identity. That version of Islam works as local theology, which embodies sacred and divine values and is perceived as local identity and ideology. Building on Tibi’s, Salim’s and Nuim’s argument on shari’a and Hall’s perspective on identity and ideology, I examine the work of shari’a in Acehnese historical times, and its relation to Acehnese culture and ideology. There are four indications that shari’a holds central role in formulating the Acehnese theology, where local cultural identity and ideology are seen as part of Islamic religiosity, namely the process of Islamization of Southeast Asia, the function of local Islamic traditional boarding education (dayah, the distribution of local power, and the work of local arts.

  20. Problem formulation as a discursive design activity

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp; Dorst, Kees; Andreasen, Mogens Myrup


    In the design methodology literature, design is often described as a rational problem solving process. This approach has been very successful; it has lead to the creation of design process models, tools, methods and techniques. Design methods teaching along these lines has become an indispensable...... part of any engineering design education. Yet the assumptions behind the rational problem solving approach to design do not sit well with some of the experiences we have in design teaching and design practice. Problem formulation is one such area where we might have to look for a different way...... to describe what is happening in design, beyond the problem solving approach. In this paper an extensive educational case study will be used to see whether a framework for describing design as a discursive activity (based on the notions of ‘discourse’ and ‘paradox’) could be more appropriate to describe...

  1. An anthropological approach to teaching health sciences students cultural competency in a field school program. (United States)

    Hutchins, Frank T; Brown, Lori DiPrete; Poulsen, Keith P


    International immersion experiences do not, in themselves, provide students with the opportunity to develop cultural competence. However, using an anthropological lens to educate students allows them to learn how to negotiate cultural differences by removing their own cultural filters and seeing events through the eyes of those who are culturally different. Faculty at the University of Wisconsin-Madison's Global Health Institute believed that an embedded experience, in which students engaged with local communities, would encourage them to adopt this Cultural Competency 2.0 position. With this goal in mind, they started the Field School for the Study of Language, Culture, and Community Health in Ecuador in 2003 to teach cultural competency to medical, veterinary, pharmacy, and nursing students. The program was rooted in medical anthropology and embraced the One Health initiative, which is a collaborative effort of multiple disciplines working locally, nationally, and globally to obtain optimal health for people, animals, and the environment. In this article, the authors identify effective practices and challenges for using a biocultural approach to educating students. In a semester-long preparatory class, students study the Spanish language, region-specific topics, and community engagement principles. While in Ecuador for five weeks, students apply their knowledge during community visits that involve homestays and service learning projects, for which they partner with local communities to meet their health needs. This combination of language and anthropological course work and community-based service learning has led to positive outcomes for the local communities as well as professional development for students and faculty.

  2. Cross-cultural nursing research. (United States)

    Suhonen, Riitta; Saarikoski, Mikko; Leino-Kilpi, Helena


    International cross-cultural comparative nursing research is considered important for the advancement of nursing knowledge offering a global perspective for nursing. Although this is recognised in policy statements and quality standards, international comparative studies are rare in database citations. To highlight the need for cross-cultural comparative research in nursing and to share some of the insights gained after conducting three international/cross-cultural comparative studies. These are: an examination of patients' autonomy, privacy and informed consent in nursing interventions BIOMED 1998-2001, the ICProject International Patient Study 2002-2006 and the Ethical Codes in Nursing (ECN) project 2003-2005. There are three critical issues raised here for discussion from the international cross-cultural studies. These are: the planning and formulating of an international study, the conduct of cross-cultural research including the implementation of rigorous data collection and analysis and the reporting and implementing the results. International and cross-cultural nursing research is powerful tool for the improvement of clinical nursing practise, education and management and advancement of knowledge. Such studies should be carried out in order to improve European evidence based health care development in which the patients' perspective plays an important part in the evaluation and benchmarking of services.

  3. A general real-time formulation for multi-rate mass transfer problems

    Directory of Open Access Journals (Sweden)

    O. Silva


    Full Text Available Many flow and transport phenomena, ranging from delayed storage in pumping tests to tailing in river or aquifer tracer breakthrough curves or slow kinetics in reactive transport, display non-equilibrium (NE behavior. These phenomena are usually modeled by non-local in time formulations, such as multi-porosity, multiple processes non equilibrium, continuous time random walk, memory functions, integro-differential equations, fractional derivatives or multi-rate mass transfer (MRMT, among others. We present a MRMT formulation that can be used to represent all these models of non equilibrium. The formulation can be extended to non-linear phenomena. Here, we develop an algorithm for linear mass transfer, which is accurate, computationally inexpensive and easy to implement in existing groundwater or river flow and transport codes. We illustrate this approach by application to published data involving NE groundwater flow and solute transport in rivers and aquifers.

  4. Dissection of culture media for embryos: the most important and less important components and characteristics. (United States)

    Gardner, David K


    Improvements in culture media formulations have led to an increase in the ability to maintain the mammalian embryo in culture throughout the preimplantation and pre-attachment period. Amino acids and specific macromolecules have been identified as being key medium components, whereas temporal dynamics have been recognised as important media characteristics. Furthermore, other laboratory factors that directly impact embryo development and viability have been identified. Such factors include the use of a reduced oxygen tension, an appropriate incubation system and an adequate prescreening of all contact supplies. With rigourous quality systems in place, it is possible to obtain in vivo rates of embryo development in vitro using new media formulations while maintaining high levels of embryo viability. The future of embryo culture will likely be based on novel culture chips capable of providing temporal dynamics while facilitating real-time analysis of embryo physiology.

  5. A comparison of biological and cultural evolution. (United States)

    Portin, Petter


    This review begins with a definition of biological evolution and a description of its general principles. This is followed by a presentation of the biological basis of culture, specifically the concept of social selection. Further, conditions for cultural evolution are proposed, including a suggestion for language being the cultural replicator corresponding to the concept of the gene in biological evolution. Principles of cultural evolution are put forward and compared to the principles of biological evolution. Special emphasis is laid on the principle of selection in cultural evolution, including presentation of the concept of cultural fitness. The importance of language as a necessary condition for cultural evolution is stressed. Subsequently, prime differences between biological and cultural evolution are presented, followed by a discussion on interaction of our genome and our culture. The review aims at contributing to the present discussion concerning the modern development of the general theory of evolution, for example by giving a tentative formulation of the necessary and sufficient conditions for cultural evolution, and proposing that human creativity and mind reading or theory of mind are motors specific for it. The paper ends with the notion of the still ongoing coevolution of genes and culture.

  6. Perspectives and Paradoxes in the sensory-cultural explorative approach

    DEFF Research Database (Denmark)

    Lundberg, Pia

    The paper presents varieties of cultural science's investigation of human sensory experience in different cultures through history. One of the discoveries of the pioneering scientists exploring human sensoria was in fact the discovery of human sense being culturally different in matter rather than...

  7. Community Collectivism : A social dynamic approach to conceptualizing culture

    NARCIS (Netherlands)

    Akkus, Birol; Postmes, Tom; Stroebe, Katherine


    Culture shapes individuals, but the measurement of cultural differences has proven a challenge. Traditional measures of cultural values focus on individual perceptions. We suggest that values are established and maintained within social communities of proximate others, such as the family and its

  8. The Implementation of a Social Constructivist Approach in Primary Science Education in Confucian Heritage Culture: The Case of Vietnam (United States)

    H?ng, Ngô Vu Thu; Meijer, Marijn Roland; Bulte, Astrid M. W.; Pilot, Albert


    Social constructivism has been increasingly studied and implemented in science school education. Nevertheless, there is a lack of holistic studies on the implementation of social constructivist approach in primary science education in Confucian heritage culture. This study aims to determine to what extent a social constructivist approach is…

  9. Granulated decontamination formulations (United States)

    Tucker, Mark D.


    A decontamination formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a sorbent additive, and water. A highly adsorbent sorbent additive (e.g., amorphous silica, sorbitol, mannitol, etc.) is used to "dry out" one or more liquid ingredients into a dry, free-flowing powder that has an extended shelf life, and is more convenient to handle and mix in the field.

  10. Effects of DCPD cement chemistry on degradation properties and cytocompatibility: comparison of MCPM/β-TCP and MCPM/HA formulations

    International Nuclear Information System (INIS)

    Alge, Daniel L; Goebel, W Scott; Chu, Tien-Min Gabriel


    Dicalcium phosphate dihydrate (DCPD) cements are attractive biomaterials for bone repair, and a number of different DCPD cement formulations have been proposed in the literature. In this study, we have specifically compared monocalcium phosphate monohydrate (MCPM)/hydroxyapatite (HA) and MCPM/β-tricalcium phosphate (β-TCP) formulations to test the hypothesis that DCPD cement chemistry affects the degradation properties and cytocompatibility of the cement. Using simple in vitro models we found that MCPM/β-TCP formulations degraded primarily by DCPD dissolution, which was associated with a slight pH drop and relatively low mass loss. Cytocompatibility testing of cement conditioned culture media revealed no significant change in cell viability relative to the negative control for all of the MCPM/β-TCP formulations. In contrast, the MCPM/HA formulations were prone to undergo rapid conversion of DCPD to HA, resulting in a sharp pH drop and extensive mass loss. A stoichiometric excess of HA in the cement was found to accelerate the conversion process, and significant cytotoxicity was observed for the MCPM/HA formulations containing excess HA. Collectively, these results show that, although the product of the setting reaction is the same, DCPD cements produced with MCPM/HA and MCPM/β-TCP formulations differ significantly in their degradation properties and cytocompatibility. These differences may have important implications for the selection of a DCPD cement formulation for clinical application. (paper)

  11. Optimization and characterization of spray-dried IgG formulations: a design of experiment approach. (United States)

    Faghihi, Homa; Najafabadi, Abdolhosein Rouholamini; Vatanara, Alireza


    The purpose of the present study is to optimize a spray-dried formulation as a model antibody regarding stability and aerodynamic property for further aerosol therapy of this group of macromolecules. A three-factor, three-level, Box-Behnken design was employed milligrams of Cysteine (X 1 ), Trehalose (X 2 ), and Tween 20 (X 3 ) as independent variables. The dependent variables were quantified and the optimized formulation was prepared accordingly. SEC-HPLC and FTIR-spectroscopy were conducted to evaluate the molecular and structural status of spray-dried preparations. Particle characterization of optimized sample was performed with the aid of DSC, SEM, and TSI examinations. Experimental responses of a total of 17 formulations resulted in yield values, (Y 1 ), ranging from 21.1 ± 0.2 to 40.2 ± 0.1 (%); beta-sheet content, (Y 2 ), from 66.22 ± 0.19 to 73.78 ± 0.26 (%); amount of aggregation following process, (Y 3 ), ranging from 0.11 ± 0.03 to 0.95 ± 0.03 (%); and amount of aggregation upon storage, (Y 4 ), from 0.81 ± 0.01 to 3.13 ± 0.64 (%) as dependent variables. Results-except for those of the beta sheet content-were fitted to quadratic models describing the inherent relationship between main factors. Co-application of Cysteine and Tween 20 preserved antibody molecules from molecular degradation and improved immediate and accelerated stability of spry-dried antibodies. Validation of the optimization study indicated high degree of prognostic ability of response surface methodology in preparation of stable spray-dried IgG. Graphical abstract Spray drying of IgG in the presence of Trehalose, Cysteine and Tween 20.

  12. Family Perspectives: Using a Cultural Prism to Understand Families from Asian Cultural Backgrounds (United States)

    Lee, Suk-Hyang; Turnbull, Ann P.; Zan, Fei


    Educators can better serve students who come from diverse cultural backgrounds by understanding the differing cultural values of these students and their families. This article explores different cultural perspectives using a cultural prism approach, focused most specifically on the Korean and Chinese cultures. (Contains 2 tables.)

  13. Developing of guidelines for counselling children of divorce within Tsonga culture



    M.A. The goals of this study were formulated in response to a need for a culturally sensitive counselling service for children of divorce within the Tsonga culture. The aim of this study was to develop guidelines to be used by counsellors in helping children of divorce within Tsonga culture. The study was undertaken within the framework of the developmental research and utilisation model. The research design integrated exploratory and descriptive methods. Qualitative methods of data gather...

  14. Nutrition and culture in professional football. A mixed method approach. (United States)

    Ono, Mutsumi; Kennedy, Eileen; Reeves, Sue; Cronin, Linda


    An adequate diet is essential for the optimal performance of professional football (soccer) players. Existing studies have shown that players fail to consume such a diet, without interrogating the reasons for this. The aim of this study was to explore the difficulties professional football players experience in consuming a diet for optimal performance. It utilized a mixed method approach, combining nutritional intake assessment with qualitative interviews, to ascertain both what was consumed and the wider cultural factors that affect consumption. The study found a high variability in individual intake which ranged widely from 2648 to 4606 kcal/day. In addition, the intake of carbohydrate was significantly lower than that recommended. The study revealed that the main food choices for carbohydrate and protein intake were pasta and chicken respectively. Interview results showed the importance of tradition within the world of professional football in structuring the players' approach to nutrition. In addition, the players' personal eating habits that derived from their class and national habitus restricted their food choice by conflicting with the dietary choices promoted within the professional football clubs. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. Total safety management: An approach to improving safety culture

    International Nuclear Information System (INIS)

    Blush, S.M.


    A little over 4 yr ago, Admiral James D. Watkins became Secretary of Energy. President Bush, who had appointed him, informed Watkins that his principal task would be to clean up the nuclear weapons complex and put the US Department of Energy (DOE) back in the business of producing tritium for the nation's nuclear deterrent. Watkins recognized that in order to achieve these objectives, he would have to substantially improve the DOE's safety culture. Safety culture is a relatively new term. The International Atomic Energy Agency (IAEA) used it in a 1986 report on the root causes of the Chernobyl nuclear accident. In 1990, the IAEA's International Nuclear Safety Advisory Group issued a document focusing directly on safety culture. It provides guidelines to the international nuclear community for measuring the effectiveness of safety culture in nuclear organizations. Safety culture has two principal aspects: an organizational framework conducive to safety and the necessary organizational and individual attitudes that promote safety. These obviously go hand in hand. An organization must create the right framework to foster the right attitudes, but individuals must have the right attitudes to create the organizational framework that will support a good safety culture. The difficulty in developing such a synergistic relationship suggests that achieving and sustaining a strong safety culture is not easy, particularly in an organization whose safety culture is in serious disrepair

  16. Neonates need tailored drug formulations. (United States)

    Allegaert, Karel


    Drugs are very strong tools used to improve outcome in neonates. Despite this fact and in contrast to tailored perfusion equipment, incubators or ventilators for neonates, we still commonly use drug formulations initially developed for adults. We would like to make the point that drug formulations given to neonates need to be tailored for this age group. Besides the obvious need to search for active compounds that take the pathophysiology of the newborn into account, this includes the dosage and formulation. The dosage or concentration should facilitate the administration of low amounts and be flexible since clearance is lower in neonates with additional extensive between-individual variability. Formulations need to be tailored for dosage variability in the low ranges and also to the clinical characteristics of neonates. A specific focus of interest during neonatal drug development therefore is a need to quantify and limit excipient exposure based on the available knowledge of their safety or toxicity. Until such tailored vials and formulations become available, compounding practices for drug formulations in neonates should be evaluated to guarantee the correct dosing, product stability and safety.

  17. A New approach to the spread of safety culture. The trend of studies and practice in the foreign nuclear power industry, and future approach

    International Nuclear Information System (INIS)

    Hasegawa, Naoko; Takano, Kenichi


    The purpose of this study is to clarify organizational factors influencing on safety and to suggest future approach for the spread of safety culture. As the results of investigations on safety companies, characteristics of organizational policies, those of safety activities' purposes, and organizational factors which encourage workers to take a positive attitude toward the safety activities were clarified. Based on the clarified characteristics and the trend of studies and practice in the foreign nuclear power industry, it was suggested that it would be necessary for the spread of safety culture in an organization to learn lessons for the prevention of accidents' recurring and to maintain safety behavior and attitude for the prevention of accidents' occurring. For support of this, it is desired to develop the assessment system of organizational safety and the planning system of safety management. The new approach was also suggested with the process model for influence of organizational factors which include workers' psychological aspects. (author)

  18. A systematic review of team formulation in clinical psychology practice: Definition, implementation, and outcomes. (United States)

    Geach, Nicole; Moghaddam, Nima G; De Boos, Danielle


    Team formulation is promoted by professional practice guidelines for clinical psychologists. However, it is unclear whether team formulation is understood/implemented in consistent ways - or whether there is outcome evidence to support the promotion of this practice. This systematic review aimed to (1) synthesize how team formulation practice is defined and implemented by practitioner psychologists and (2) analyse the range of team formulation outcomes in the peer-reviewed literature. Seven electronic bibliographic databases were searched in June 2016. Eleven articles met inclusion criteria and were quality assessed. Extracted data were synthesized using content analysis. Descriptions of team formulation revealed three main forms of instantiation: (1) a structured, consultation approach; (2) semi-structured, reflective practice meetings; and (3) unstructured/informal sharing of ideas through routine interactions. Outcome evidence linked team formulation to a range of outcomes for staff teams and service users, including some negative outcomes. Quality appraisal identified significant issues with evaluation methods; such that, overall, outcomes were not well-supported. There is weak evidence to support the claimed beneficial outcomes of team formulation in practice. There is a need for greater specification and standardization of 'team formulation' practices, to enable a clearer understanding of any relationships with outcomes and implications for best-practice implementations. Under the umbrella term of 'team formulation', three types of practice are reported: (1) highly structured consultation; (2) reflective practice meetings; and (3) informal sharing of ideas. Outcomes linked to team formulation, including some negative outcomes, were not well evidenced. Research using robust study designs is required to investigate the process and outcomes of team formulation practice. © 2017 The British Psychological Society.

  19. Transformation of rural-urban cultural landscapes in Europe: Integrating approaches from ecological, socio-economic and planning perspectives

    Directory of Open Access Journals (Sweden)

    S. Pauleit


    Full Text Available This paper presents a review of the presentations and synthesis of the discussion during a Symposium on ‘Transformation of rural-urban cultural landscapes in Europe: Integrating approaches from ecological, socio-economic and planning perspectives’ held at the European IALE conference 2009 in Salzburg, Austria. The symposium addressed an extended and much debated subject of the landscape dynamics in Europe. The papers presented during the symposium showcased a broad spectrum of cutting edge research questions and challenges faced by the cultural landscapes of Europe. During six sessions, 18 presentations (besides 20 posters were made by 36 scientists (including co-authors from 14 countries, representing 25 institutions of Europe. A glance at the presentations revealed that the state-of-the-art focuses on driving forces and selected aspects of transformation processes, methods of its analysis and planning support as dimensions of research in this field. However, inter- and transdisciplinary research and integrative approaches to the development of rural-urban cultural landscapes are needed. The extended discussion session at the latter part of the symposium highlighted some critical and unaddressed research questions which remained a pending agenda for future research.

  20. Topical formulations with superoxide dismutase: influence of formulation composition on physical stability and enzymatic activity. (United States)

    Di Mambro, Valéria M; Borin, Maria F; Fonseca, Maria J V


    Three different topical formulations were supplemented with superoxide dismutase (SOD) and evaluated concerning physical and chemical stabilities in order to determine the most stable formulation that would maintain SOD activity. Physical stability was evaluated by storing the formulation at room temperature, and at 37 and 45 degrees C for 28 days. Samples were collected at 7-day intervals for assessment of rheological behavior. Chemical stability was evaluated by the measurement of enzymatic activity in formulations stored at room temperature and at 45 degrees C for 75 days. The formulations showed a pseudoplastic behavior, with a flow index of less than 1. There was no significant difference in the initial values of flow index, hysteresis loop or minimum apparent viscosity. The simple emulsion and the one stabilized with hydroxyethylcellulose showed decreased viscosity by the 21st day and with higher temperature, but no significant changes concerning the presence of SOD. Although there were no significant changes concerning storage time or temperature, the formulation stabilized with hydroxyethylcellulose showed a marked loss of SOD activity. The addition of SOD to the formulations studied did not affect their physical stability. Simple emulsions or emulsions stabilized with carboxypolymethylene seem to be better bases for enzyme addition than emulsion stabilized with hydroxyethylcellulose.

  1. The tourism image of Estonia in Spain: a formulative approach

    Directory of Open Access Journals (Sweden)

    Katlin Savva


    Full Text Available We are living in an environment, where information flow is freer than ever. Nowadays everyone has access to global news and can make their own conclu-sions based on the perceived image. Therefore, the role of perception and image is becoming more important for different countries to attract visitors and in-vestors. Tourism is a way of selling the image of a country and the reputation and word of mouth generated from tourism activities are priceless to the image of a destination. This paper analyzes the case of Estonia, which is an emerging tourism market and quite new and unknown for Spain. The authors try to accent the importance of direct promotion, through a survey carried out to 341 Spanish people in Madrid. The result from this quantitative and formulative research method is that Estonia has to promote its tourism image better if the country wants to attract the Spanish tourist.

  2. Flow Formulation-based Model for the Curriculum-based Course Timetabling Problem

    DEFF Research Database (Denmark)

    Bagger, Niels-Christian Fink; Kristiansen, Simon; Sørensen, Matias


    problem. This decreases the number of integer variables signicantly and improves the performance compared to the basic formulation. It also shows competitiveness with other approaches based on mixed integer programming from the literature and improves the currently best known lower bound on one data...... instance in the benchmark data set from the second international timetabling competition.......In this work we will present a new mixed integer programming formulation for the curriculum-based course timetabling problem. We show that the model contains an underlying network model by dividing the problem into two models and then connecting the two models back into one model using a maximum ow...

  3. Radiation safely culture in nuclear facilities

    International Nuclear Information System (INIS)

    Coates, R.


    The importance of developing a sound radiation safety culture is a relatively new development in the practical application of radiation protection in operational facilities. It is instructive to trace the evolution of the fundamental approaches to controlling operational exposures, staring with the engineering-based 'Distance, Shielding and Time' mantra, through the growing emphasis on ALARA and systematic management-based approaches, towards a recognition of the importance of developing a more 'hearts and minds' approach based within the wider safety culture of the organization. The underlying requirements for developing a strong radiation safety culture are not novel, and are largely identical to those necessary for nuclear safety culture, which is why an integrated approach to culture within the organization is essential

  4. Personality disorders and culture: contemporary clinical views (Part B). (United States)

    Alarcón, R D; Foulks, E F


    This article reviews the basic concepts surrounding the clinical relationships between culture and personality disorders (PDs). Part A of this article, which appeared in Cultural Diversity and Mental Health, Vol. 1, No. 1, pp 3-17 (1995), examined the interpretive/explanatory and pathogenic/ pathoplastic roles of culture. Herein, culture's role as a diagnostic/nosological factor is discussed through the use of measurement instruments and the cultural formulation included in DSM-IV (American Psychiatric Association, 1994). In addition to these three roles, some authors would also consider a therapeutic/protective function for cultured in PDs. Following a critique of the biological perspective, a research model based on the definition of the cultural profile and the estimation of the cultural distance between clinical examiners and populations is proposed. It is important to reject both biological reductionism and the extremes of cultural determinism, in order to better assess the intraethnic distribution of psychopathology, and interethnic variations represented by the notion of cultural relativism.


    Directory of Open Access Journals (Sweden)

    Agil Valiyev


    Full Text Available Today, culture is one of the main feeble factors of economic development.  The leading role of culture in economic development should be argued as multiplied: so, on firstly, as domestic value, on secondly, as a main factor of regional economic development advanced to raised gravity of different regions for residents, tourists and investors, on thirdly, as major parameters of social development based on tolerance, creativity and knowledge. To the different international experiences, culture is main part of economic development in our life. Cultural diversities are combined into a main reason economic development model. The article consist of explainations about the understanding of culture, cultural diplomacy and economics, approach on conflicts between culture and economics, to find how affecting of culture to economic development, the role of culture in economic development of Azerbaijan. The article can be considered as a useful resource  for experts and researchers conducting research in this field.

  6. Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin. (United States)

    Milewski, Mikolaj; Brogden, Nicole K; Stinchcomb, Audra L


    The efficacy of microneedles in the area of transdermal drug delivery is well documented. Multiple studies have shown that enhancement of skin permeation by means of the creation of microscopic pores in the stratum corneum can greatly improve the delivery rates of drugs. However, skin pretreatment with microneedles is not the only factor affecting drug transport rates. Other factors, including drug formulation and rate of micropore closure, are also important for optimizing delivery by this route. This review aims to highlight work that has been done in these areas, with an emphasis on drug formulation parameters that affect transdermal flux. This review creates an appreciation for the many factors affecting microneedle-enhanced delivery. Most results clearly indicate that microneedle skin pretreatment by itself may have different effects on drug transport depending on the formulation used, and formulation characteristics have different effects on the transport through untreated skin and microneedle-treated skin. Several formulation approaches are reported to optimize microneedle-enhanced drug delivery, including co-solvent use, vesicular, nanoparticulate and gel systems. In addition to well-established factors that affect microneedle-assisted delivery (geometry, type of microneedle, etc.), formulation and pore viability are also critical factors that must be considered.

  7. Incorporating organisational safety culture within ergonomics practice. (United States)

    Bentley, Tim; Tappin, David


    This paper conceptualises organisational safety culture and considers its relevance to ergonomics practice. Issues discussed in the paper include the modest contribution that ergonomists and ergonomics as a discipline have made to this burgeoning field of study and the significance of safety culture to a systems approach. The relevance of safety culture to ergonomics work with regard to the analysis, design, implementation and evaluation process, and implications for participatory ergonomics approaches, are also discussed. A potential user-friendly, qualitative approach to assessing safety culture as part of ergonomics work is presented, based on a recently published conceptual framework that recognises the dynamic and multi-dimensional nature of safety culture. The paper concludes by considering the use of such an approach, where an understanding of different aspects of safety culture within an organisation is seen as important to the success of ergonomics projects. STATEMENT OF RELEVANCE: The relevance of safety culture to ergonomics practice is a key focus of this paper, including its relationship with the systems approach, participatory ergonomics and the ergonomics analysis, design, implementation and evaluation process. An approach to assessing safety culture as part of ergonomics work is presented.

  8. Baseline LAW Glass Formulation Testing

    International Nuclear Information System (INIS)

    Kruger, Albert A.; Mooers, Cavin; Bazemore, Gina; Pegg, Ian L.; Hight, Kenneth; Lai, Shan Tao; Buechele, Andrew; Rielley, Elizabeth; Gan, Hao; Muller, Isabelle S.; Cecil, Richard


    The major objective of the baseline glass formulation work was to develop and select glass formulations that are compliant with contractual and processing requirements for each of the LAW waste streams. Other objectives of the work included preparation and characterization of glasses with respect to the properties of interest, optimization of sulfate loading in the glasses, evaluation of ability to achieve waste loading limits, testing to demonstrate compatibility of glass melts with melter materials of construction, development of glass formulations to support ILAW qualification activities, and identification of glass formulation issues with respect to contract specifications and processing requirements

  9. Driving Cultures: Cars, Young People and Cultural Research

    Directory of Open Access Journals (Sweden)

    Sarah Redshaw


    Full Text Available This article describes the Driving Cultures research, the cultural importance of the car and the psychological approaches central to research in the field of road safety and investigations of the over–representation of young people in crashes. The aim of the article is to outline driving as a cultural practice drawing on the experiences of young people as described in focus groups in order to show how cultural research can contribute to a social concern such as traffic injury and death.

  10. A Semantic Approach for Recommendations generation: some Cultural Heritage applications

    Directory of Open Access Journals (Sweden)

    Maurizio De Tommasi


    Full Text Available EnThe growing availability of data in the information systems has raised the challenging problem of distinguishing between the resources that belong to the same information context. Starting from the hypothesis that the information system is based on Semantic Web technologies, is it possible to use these technologies to make an information system more adaptive to user requirements in order to enable personalization and differentiation mechanisms in the information delivery process?This paper proposes an approach to building recommendations by using Semantic Web technologies, in order to give the users a different access to the information. The outcome is a semantic recommender engine, capable of retrieving and ranking semantically annotated resources, by using a set of domain ontologies and a semantic matching algorithm. We are showing some applications of this model in the Cultural Heritage domain in which the presented approach seems to be particularly effective, due to the richness of semantic structures and models existing for such domain.ItLa crescente quantità di dati disponibili da parte dei sistemi informativi ha sollevato il complesso problema della distinzione tra risorse appartenenti allo stesso contesto informativo. Partendo dall'ipotesi che il sistema informativo si basi sulle tecnologie proprie del Web Semantico, è possibile utilizzare tali tecnologie per rendere il sistema adattivo ai requisiti dell'utente, abilitando, in questo modo, meccanismi di personalizzazione e differenziazione?Questo articolo propone un approccio per la generazione di recommendation,  utilizzando le tecnologie del Web Semantico, al fine di fornire, ai singoli utenti, accessi differenziati alle informazioni. Il risultato è un motore di generazione di recommendation semantiche, in grado di recuperare e classificare risorse annotate semanticamente, avvalendosi di un set di ontologie di dominio e di un algoritmo di matching semantico. Saranno

  11. A Fourth Order Formulation of DDM for Crack Analysis in Brittle Solids

    Directory of Open Access Journals (Sweden)

    Abolfazl Abdollahipour


    Full Text Available A fourth order formulation of the displacement discontinuity method (DDM is proposed for the crack analysis of brittle solids such as rocks, glasses, concretes and ceramics. A fourth order boundary collocation scheme is used for the discretization of each boundary element (the source element. In this approach, the source boundary element is divided into five sub-elements each recognized by a central node where the displacement discontinuity components are to be numerically evaluated. Three different formulating procedures are presented and their corresponding discretization schemes are discussed. A new discretization scheme is also proposed to use the fourth order formulation for the special crack tip elements which may be used to increase the accuracy of the stress and displacement fields near the crack ends. Therefore, these new crack tips discretizing schemes are also improved by using the proposed fourth order displacement discontinuity formulation and the corresponding shape functions for a bunch of five special crack tip elements. Some example problems in brittle fracture mechanics are solved for estimating the Mode I and Mode II stress intensity factors near the crack ends. These semi-analytical results are compared to those cited in the fracture mechanics literature whereby the high accuracy of the fourth order DDM formulation is demonstrated.

  12. From Learning Cultures to Educational Cultures: Values and Judgements in Educational Research and Educational Improvement (United States)

    Biesta, Gert


    This article outlines a new approach to the study of learning and the improvement of education. The approach consists of two elements: a theory of learning cultures and a cultural theory of learning. Learning cultures are different from learning contexts or learning environments in that they are to be understood as the social practices through…

  13. Conceptions of ‘culture' in international communication - Limits to cultural explanations?

    DEFF Research Database (Denmark)

    Froholdt, Lisa Loloma; Knudsen, Fabienne


    The paper addresses a critical approach to static, objective and context-independent concept of culture. Conceiving of another culture as objective, persistent, and evenly shared features within a nation may bring some basic order while facing an unknown culture, but it may also have unintentional...

  14. A Framework for Understanding Chinese Leadership: A Cultural Approach (United States)

    Liu, Peng


    Chinese culture is widely regarded as being dominated by Confucian thought, which is characterized as focusing on morality, relationalism and collectivism. Also, Chinese culture has been deemed to be very hierarchical and lacking in a sense of autonomy. However, there has been little attention paid to other diverse elements in Chinese culture and…

  15. Challenging patient safety culture: survey results

    NARCIS (Netherlands)

    Hellings, Johan; Schrooten, Ward; Klazinga, Niek; Vleugels, Arthur


    PURPOSE: The purpose of this paper is to measure patient safety culture in five Belgian general hospitals. Safety culture plays an important role in the approach towards greater patient safety in hospitals. DESIGN/METHODOLOGY/APPROACH: The Patient Safety Culture Hospital questionnaire was

  16. The renaissance of continuous culture in the post-genomics age. (United States)

    Bull, Alan T


    The development of continuous culture techniques 60 years ago and the subsequent formulation of theory and the diversification of experimental systems revolutionised microbiology and heralded a unique period of innovative research. Then, progressively, molecular biology and thence genomics and related high-information-density omics technologies took centre stage and microbial growth physiology in general faded from educational programmes and research funding priorities alike. However, there has been a gathering appreciation over the past decade that if the claims of systems biology are going to be realised, they will have to be based on rigorously controlled and reproducible microbial and cell growth platforms. This revival of continuous culture will be long lasting because its recognition as the growth system of choice is firmly established. The purpose of this review, therefore, is to remind microbiologists, particularly those new to continuous culture approaches, of the legacy of what I call the first age of continuous culture, and to explore a selection of researches that are using these techniques in this post-genomics age. The review looks at the impact of continuous culture across a comprehensive range of microbiological research and development. The ability to establish (quasi-) steady state conditions is a frequently stated advantage of continuous cultures thereby allowing environmental parameters to be manipulated without causing concomitant changes in the specific growth rate. However, the use of continuous cultures also enables the critical study of specified transition states and chemical, physical or biological perturbations. Such dynamic analyses enhance our understanding of microbial ecology and microbial pathology for example, and offer a wider scope for innovative drug discovery; they also can inform the optimization of batch and fed-batch operations that are characterized by sequential transitions states.

  17. Developments in the formulation and delivery of spray dried vaccines. (United States)

    Kanojia, Gaurav; Have, Rimko Ten; Soema, Peter C; Frijlink, Henderik; Amorij, Jean-Pierre; Kersten, Gideon


    Spray drying is a promising method for the stabilization of vaccines, which are usually formulated as liquids. Usually, vaccine stability is improved by spray drying in the presence of a range of excipients. Unlike freeze drying, there is no freezing step involved, thus the damage related to this step is avoided. The edge of spray drying resides in its ability for particles to be engineered to desired requirements, which can be used in various vaccine delivery methods and routes. Although several spray dried vaccines have shown encouraging preclinical results, the number of vaccines that have been tested in clinical trials is limited, indicating a relatively new area of vaccine stabilization and delivery. This article reviews the current status of spray dried vaccine formulations and delivery methods. In particular it discusses the impact of process stresses on vaccine integrity, the application of excipients in spray drying of vaccines, process and formulation optimization strategies based on Design of Experiment approaches as well as opportunities for future application of spray dried vaccine powders for vaccine delivery.

  18. Developments in the formulation and delivery of spray dried vaccines (United States)

    Kanojia, Gaurav; Have, Rimko ten; Soema, Peter C.; Frijlink, Henderik; Amorij, Jean-Pierre; Kersten, Gideon


    ABSTRACT Spray drying is a promising method for the stabilization of vaccines, which are usually formulated as liquids. Usually, vaccine stability is improved by spray drying in the presence of a range of excipients. Unlike freeze drying, there is no freezing step involved, thus the damage related to this step is avoided. The edge of spray drying resides in its ability for particles to be engineered to desired requirements, which can be used in various vaccine delivery methods and routes. Although several spray dried vaccines have shown encouraging preclinical results, the number of vaccines that have been tested in clinical trials is limited, indicating a relatively new area of vaccine stabilization and delivery. This article reviews the current status of spray dried vaccine formulations and delivery methods. In particular it discusses the impact of process stresses on vaccine integrity, the application of excipients in spray drying of vaccines, process and formulation optimization strategies based on Design of Experiment approaches as well as opportunities for future application of spray dried vaccine powders for vaccine delivery. PMID:28925794

  19. Application of hanging drop technique to optimize human IgG formulations. (United States)

    Li, Guohua; Kasha, Purna C; Late, Sameer; Banga, Ajay K


    The purpose of this work is to assess the hanging drop technique in screening excipients to develop optimal formulations for human immunoglobulin G (IgG). A microdrop of human IgG and test solution hanging from a cover slide and undergoing vapour diffusion was monitored by a stereomicroscope. Aqueous solutions of IgG in the presence of different pH, salt concentrations and excipients were prepared and characterized. Low concentration of either sodium/potassium phosphate or McIlvaine buffer favoured the solubility of IgG. Addition of sucrose favoured the stability of this antibody while addition of NaCl caused more aggregation. Antimicrobial preservatives were also screened and a complex effect at different buffer conditions was observed. Dynamic light scattering, differential scanning calorimetry and size exclusion chromatography studies were performed to further validate the results. In conclusion, hanging drop is a very easy and effective approach to screen protein formulations in the early stage of formulation development.

  20. Approaches to pre-formulation R and D for phytopharmaceuticals emanating from herb based traditional Ayurvedic processes

    Directory of Open Access Journals (Sweden)

    D B Anantha Narayana


    Full Text Available Botanicals constitute a large part of the drugs from the traditional medicine (TM and ethno medicine (EM known for their history of safe use (HOSU. Phytopharmaceuticals having a base of such origin offer high advantages as they come with safety profiles, and often allow extrapolation of the HOSU data, under certain circumstances. However, while current pharmaceutical technologies are being adopted by the industry to make phytopharmaceuticals with such origin, there is a need for preformulation research and development (R and D during formulation. Some suggestions for R and D studies in case of aqueous extracts known in Ayurveda, converted on an industrial scale to obtain a phytopharmaceutical, and formulated as a solid dosage form (granules, tablets, or capsules are discussed.

  1. Terbinafine: novel formulations that potentiate antifungal activities. (United States)

    Ma, Y; Chen, X; Guan, S


    Terbinafine, an orally and topically active antifungal agent, has been available for the treatment of dermatophytic infections and onychomycosis for more than a decade. In addition, oral administration has been shown to be associated with drug-drug interactions, hepatotoxicity, low concentration at the infected sites, gastrointestinal and systemic side effects and other adverse effects. Since topical drug delivery can provide higher patient compliance, allow immediate access to the infected site and reduce unwanted systemic drug exposure, an improved topical drug delivery approach with high permeability, sustained release and prolonged retainment could overcome the limitations and side effects caused by oral administration. Conventional topical formulations cannot keep the drug in the targeted sites for a long duration of time and hence a novel drug delivery that can avoid the side effects while still providing sustained efficacy in treatment should be developed. This brief review of novel formulations based on polymers and nanostructure carriers provides insight into the efficacy and topical delivery of terbinafine. Copyright 2015 Prous Science, S.A.U. or its licensors. All rights reserved.

  2. A new LP formulation of the admission control problem modelled as an MDP under average reward criterion (United States)

    Pietrabissa, Antonio


    The admission control problem can be modelled as a Markov decision process (MDP) under the average cost criterion and formulated as a linear programming (LP) problem. The LP formulation is attractive in the present and future communication networks, which support an increasing number of classes of service, since it can be used to explicitly control class-level requirements, such as class blocking probabilities. On the other hand, the LP formulation suffers from scalability problems as the number C of classes increases. This article proposes a new LP formulation, which, even if it does not introduce any approximation, is much more scalable: the problem size reduction with respect to the standard LP formulation is O((C + 1)2/2 C ). Theoretical and numerical simulation results prove the effectiveness of the proposed approach.

  3. "Phronesis" on tour: cultural adaptability of Aristotelian ethical notions. (United States)

    Polansky, R


    How might bioethics take account of cultural diversity? Can practical wisdom of an Aristotelian sort be applied across cultures? After showing that practical wisdom involves both intellectual cleverness and moral virtue, it is argued that both these components have universality. Hence practical wisdom must be universal as well. Hellenic ethical thought neither depended on outdated theoretical notions nor limited itself to the Greek world, but was in fact developed with constant awareness of cultural differences, so it arguably works as well in other times and places when formulated. Even the eudaemonistic setting for practical wisdom is unproblematic.

  4. GHS additivity formula: can it predict the acute systemic toxicity of agrochemical formulations that contain acutely toxic ingredients? (United States)

    Van Cott, Andrew; Hastings, Charles E; Landsiedel, Robert; Kolle, Susanne; Stinchcombe, Stefan


    In vivo acute systemic testing is a regulatory requirement for agrochemical formulations. GHS specifies an alternative computational approach (GHS additivity formula) for calculating the acute toxicity of mixtures. We collected acute systemic toxicity data from formulations that contained one of several acutely-toxic active ingredients. The resulting acute data set includes 210 formulations tested for oral toxicity, 128 formulations tested for inhalation toxicity and 31 formulations tested for dermal toxicity. The GHS additivity formula was applied to each of these formulations and compared with the experimental in vivo result. In the acute oral assay, the GHS additivity formula misclassified 110 formulations using the GHS classification criteria (48% accuracy) and 119 formulations using the USEPA classification criteria (43% accuracy). With acute inhalation, the GHS additivity formula misclassified 50 formulations using the GHS classification criteria (61% accuracy) and 34 formulations using the USEPA classification criteria (73% accuracy). For acute dermal toxicity, the GHS additivity formula misclassified 16 formulations using the GHS classification criteria (48% accuracy) and 20 formulations using the USEPA classification criteria (36% accuracy). This data indicates the acute systemic toxicity of many formulations is not the sum of the ingredients' toxicity (additivity); but rather, ingredients in a formulation can interact to result in lower or higher toxicity than predicted by the GHS additivity formula. Copyright © 2018 Elsevier Inc. All rights reserved.

  5. Development of a microparticle-based dry powder inhalation formulation of ciprofloxacin hydrochloride applying the quality by design approach

    Directory of Open Access Journals (Sweden)

    Karimi K


    Full Text Available Keyhaneh Karimi, Edina Pallagi, Piroska Szabó-Révész, Ildikó Csóka, Rita Ambrus Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary Abstract: Pulmonary drug delivery of ciprofloxacin hydrochloride offers effective local antibacterial activity and convenience of easy application. Spray drying is a trustworthy technique for the production of ciprofloxacin hydrochloride microparticles. Quality by design (QbD, an up-to-date regulatory-based quality management method, was used to predict the final quality of the product. According to the QbD-based theoretical preliminary parameter ranking and priority classification, dry powder inhalation formulation tests were successfully performed in practice. When focusing on the critical parameters, the practical development was more effective and was in correlation with our previous findings. Spray drying produced spherical microparticles. The dry powder formulations prepared were examined by particle size analysis, scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimetry, and in vitro drug release and aerodynamic particle size analyses were also performed. These formulations showed an appropriate particle size ranging between 2 and 4 µm and displayed an enhanced aerosol performance with fine particle fraction up to 80%. Keywords: antibiotic, carrier-free formulation, quality by design, aerodynamic evaluation, dry powder for inhalation

  6. Duddingtonia flagrans formulated in rice bran in the control of Oesophagostomum spp. intestinal parasite of swine. (United States)

    Facchini Rodrigues, João Victor; Braga, Fabio Ribeiro; Campos, Artur Kanadani; de Carvalho, Lorendane Millena; Araujo, Juliana Milani; Aguiar, Anderson Rocha; Ferraz, Carolina Magri; da Silveira, Wendeo Ferreira; Valadão, Marisa Caixeta; de Oliveira, Thais; de Freitas, Samuel Galvão; de Araújo, Jackson Victor


    Three experimental assays with Duddingtonia flagrans (isolated AC001) were carried out. The growth of the genus Duddingtonia present in formulation of rice bran, its predatory capability on Oesophagostomum spp. infective larvae (L 3 ) in petri dishes (assay 1), its action in faecal cultures with eggs of that parasite (assay 2) and isolate's capability of predation after passing through gastrointestinal tract of swine (assay 3) was evaluated. At assay 3, feces were collected at time intervals of 12, 24, 36, 48, and 60 h after feed animals with the formulation. Assays 1 and 2 showed a statistical difference (p  0.05). The results demonstrate that the fungal isolate AC001 formulated in rice bran can prey on L 3 of Oesophagostomum spp., in vitro and after passing through the gastrointestinal tract, without loss of viability. This isolate may be an alternative in the control of Oesophagostomum spp. in swine. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. An approach for generating trajectory-based dynamics which conserves the canonical distribution in the phase space formulation of quantum mechanics. II. Thermal correlation functions. (United States)

    Liu, Jian; Miller, William H


    We show the exact expression of the quantum mechanical time correlation function in the phase space formulation of quantum mechanics. The trajectory-based dynamics that conserves the quantum canonical distribution-equilibrium Liouville dynamics (ELD) proposed in Paper I is then used to approximately evaluate the exact expression. It gives exact thermal correlation functions (of even nonlinear operators, i.e., nonlinear functions of position or momentum operators) in the classical, high temperature, and harmonic limits. Various methods have been presented for the implementation of ELD. Numerical tests of the ELD approach in the Wigner or Husimi phase space have been made for a harmonic oscillator and two strongly anharmonic model problems, for each potential autocorrelation functions of both linear and nonlinear operators have been calculated. It suggests ELD can be a potentially useful approach for describing quantum effects for complex systems in condense phase.

  8. Pharmacokinetic and Pharmacodynamic Characteristics of a New Pediatric Formulation of Artemether-Lumefantrine in African Children with Uncomplicated Plasmodium falciparum Malaria▿


    Djimdé, Abdoulaye A.; Tekete, Mamadou; Abdulla, Salim; Lyimo, John; Bassat, Quique; Mandomando, Inacio; Lefèvre, Gilbert; Borrmann, Steffen


    The pharmacokinetic and pharmacodynamic properties of a new pediatric formulation of artemether-lumefantrine, dispersible tablet, were determined within the context of a multicenter, randomized, parallel-group study. In an exploratory approach, we compared a new pediatric formulation with the tablet formulation administered crushed in the treatment of African children with uncomplicated Plasmodium falciparum malaria. Patients were randomized to 3 different dosing groups (weights of 5 to

  9. Cultural study in design : In search of a meaningful approach

    NARCIS (Netherlands)

    van Boeijen, A.G.C.


    Does the Circuit of Culture help design students to do a cultural study that is meaningful for their design project? Indeed, it provides a good view on the phenomenon culture, its complexity and how contemporary cultures can be studied, providing an overview and structure of the processes that

  10. Yield improvement strategies for the production of secondary metabolites in plant tissue culture: silymarin from Silybum marianum tissue culture. (United States)

    AbouZid, S


    Plant cell culture can be a potential source for the production of important secondary metabolites. This technology bears many advantages over conventional agricultural methods. The main problem to arrive at a cost-effective process is the low productivity. This is mainly due to lack of differentiation in the cultured cells. Many approaches have been used to maximise the yield of secondary metabolites produced by cultured plant cells. Among these approaches: choosing a plant with a high biosynthetic capacity, obtaining efficient cell line for growth and production of metabolite of interest, manipulating culture conditions, elicitation, metabolic engineering and organ culture. This article gives an overview of the various approaches used to maximise the production of pharmaceutically important secondary metabolites in plant cell cultures. Examples of using these different approaches are shown for the production of silymarin from Silybum marianum tissue culture.

  11. A generalized transport-velocity formulation for smoothed particle hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Chi; Hu, Xiangyu Y., E-mail:; Adams, Nikolaus A.


    The standard smoothed particle hydrodynamics (SPH) method suffers from tensile instability. In fluid-dynamics simulations this instability leads to particle clumping and void regions when negative pressure occurs. In solid-dynamics simulations, it results in unphysical structure fragmentation. In this work the transport-velocity formulation of Adami et al. (2013) is generalized for providing a solution of this long-standing problem. Other than imposing a global background pressure, a variable background pressure is used to modify the particle transport velocity and eliminate the tensile instability completely. Furthermore, such a modification is localized by defining a shortened smoothing length. The generalized formulation is suitable for fluid and solid materials with and without free surfaces. The results of extensive numerical tests on both fluid and solid dynamics problems indicate that the new method provides a unified approach for multi-physics SPH simulations.

  12. Organizations, projects and culture

    NARCIS (Netherlands)

    J. van Cleeff; Pieter van Nispen tot Pannerden


    Purpose: to explore and demonstrate the effects of organizational culture on projects, in particular project culture and project management style. Methodology/approach: descriptive and explorative; through students’ groups. Findings: the cultural relationship between organizations, their projects

  13. Formulation of Pine Tar Antidandruff Shampoo Assessment and Comparison With Some Commercial Formulations

    Directory of Open Access Journals (Sweden)

    M. Gharavi


    Full Text Available In this study a pine tar shampoo as a new antidandruff formulation is presented. Assessment of antidandruff preparations has been hampered by the lack of standardized schedules, and reliable methods of evaluation.Some antidandruff agents such as : Zinc pyri-thione pine tar, selenium sulphide and (sulfure were used in shampoos. Samples were coded as numbers 1,2 formulated by us and 3,4 formulated commercially. The grading scheme based on 10 point scale, and corneocyte count was carried out on 50 selected volunte¬ers. Corneocyte count and fungal study proved that pine tor shampoo is effective against pityrosporum ovale. Draize lest was used for determination of the irritancy potential of the samples. Results showed that samples numbered 1,2 were relatively innocous in comparison with the others. I urthermore,s kin sensitination test on rabbit also confirmed the results obtained by Draize test. Consumer judgments proved that all formulations were acceptable.

  14. Design of analog networks in the control theory formulation. Part 2: Numerical results


    Zemliak, A. M.


    The paper presents numerical results of design of nonlinear electronic networks based on the problem formulation in terms of the control theory. Several examples illustrate the prospects of the approach suggested in the first part of the work.

  15. Emotion regulation strategies: procedure modeling of J. Gross and cultural activity approach

    Directory of Open Access Journals (Sweden)

    Elena I. Pervichko


    Full Text Available The first part of this paper argued the desirability of structural-dynamic model of emotion regulation in the theoretical and methodological framework of cultural activity paradigm with the construction of a psychologically-based typology of emotion regulation strategies in norm and pathology, and also psychological mechanisms enabling the regulation of emotions. This conclusion was based on the analysis of the basic concepts and paradigms in which the issue of emotion regulation is studied: cognitive and psychoanalytic approaches, concept and emotional development of emotional intelligence, cultural activity approach. The paper considers the procedure model of emotion regulation by J. Gross, identifies emotion regulation strategies and evaluates their effectiveness. The possibilities and limitations of the model. Based on the review of the today research the conclusion is arrived at that the existing labels on a wide range of regulatory strategies remain an open issue.The author’s definition of emotion regulation is drawn. Emotion regulation is deemed as a set of mental processes, psychological mechanisms and regulatory strategies that people use to preserve the capacity for productive activities in a situation of emotional stress; to ensure optimal impulse control and emotions; to maintain the excitement at the optimum level. The second part of this paper provides the general description of emotion regulation strategies, the approach to their typology, the psychological mechanisms of emotion regulation that lie in the basis of this typology, i.e. the main elements of the structural-dynamic model of emotion regulation. The work shows theoretical and methodological efficacy of empirical significance of signs and symbols and also personal reflection. The diagnostic system to allow empirically identify a wide range of emotion regulation strategies is suggested. The psychological mechanisms used by the subject to solve the problem of emotional

  16. A modified Continuous Quality Improvement approach to improve culturally and socially inclusive care within rural health services. (United States)

    Mitchell, Olivia; Malatzky, Christina; Bourke, Lisa; Farmer, Jane


    The sickest Australians are often those belonging to non-privileged groups, including Indigenous Australians, gay, lesbian, bisexual, transsexual, intersex and queer people, people from culturally and linguistically diverse backgrounds, socioeconomically disadvantaged groups, and people with disabilities and low English literacy. These consumers are not always engaged by, or included within, mainstream health services, particularly in rural Australia where health services are limited in number and tend to be generalist in nature. The aim of this study was to present a new approach for improving the sociocultural inclusivity of mainstream, generalist, rural, health care organisations. This approach combines a modified Continuous Quality Improvement framework with Participatory Action Research principles and Foucault's concepts of power, discourse and resistance to develop a change process that deconstructs the power relations that currently exclude marginalised rural health consumers from mainstream health services. It sets up processes for continuous learning and consumer responsiveness. The approach proposed could provide a Continuous Quality Improvement process for creating more inclusive mainstream health institutions and fostering better engagement with many marginalised groups in rural communities to improve their access to health care. The approach to improving cultural inclusion in mainstream rural health services presented in this article builds on existing initiatives. This approach focuses on engaging on-the-ground staff in the need for change and preparing the service for genuine community consultation and responsive change. It is currently being trialled and evaluated. © 2018 National Rural Health Alliance Ltd.

  17. Supporting culturally and linguistically diverse children with speech, language and communication needs: Overarching principles, individual approaches. (United States)

    Verdon, Sarah; McLeod, Sharynne; Wong, Sandie


    Speech-language pathologists (SLPs) are working with an increasing number of families from culturally and linguistically diverse backgrounds as the world's population continues to become more internationally mobile. The heterogeneity of these diverse populations makes it impossible to identify and document a one size fits all strategy for working with culturally and linguistically diverse families. This paper explores approaches to practice by SLPs identified as specialising in multilingual and multicultural practice in culturally and linguistically diverse contexts from around the world. Data were obtained from ethnographic observation of 14 sites in 5 countries on 4 continents. The sites included hospital settings, university clinics, school-based settings, private practices and Indigenous community-based services. There were 652 individual artefacts collected from the sites which included interview transcripts, photographs, videos, narrative reflections, informal and formal field notes. The data were analysed using Cultural-Historical Activity Theory (Engeström, 1987). From the analysis six overarching Principles of Culturally Competent Practice (PCCP) were identified. These were: (1) identification of culturally appropriate and mutually motivating therapy goals, (2) knowledge of languages and culture, (3) use of culturally appropriate resources, (4) consideration of the cultural, social and political context, (5) consultation with families and communities, and (6) collaboration between professionals. These overarching principles align with the six position statements developed by the International Expert Panel on Multilingual Children's Speech (2012) which aim to enhance the cultural competence of speech pathologists and their practice. The international examples provided in the current study demonstrate the individualised ways that these overarching principles are enacted in a range of different organisational, social, cultural and political contexts

  18. A Ffowcs Williams and Hawkings formulation for hydroacoustic analysis of propeller sheet cavitation (United States)

    Testa, C.; Ianniello, S.; Salvatore, F.


    A novel hydroacoustic formulation for the prediction of tonal noise emitted by marine propellers in presence of unsteady sheet cavitation, is presented. The approach is based on the standard Ffowcs Williams and Hawkings equation and the use of transpiration (velocity and acceleration) terms, accounting for the time evolution of the vapour cavity attached on the blade surface. Drawbacks and potentialities of the method are tested on a marine propeller operating in a nonhomogeneous onset flow, by exploiting the hydrodynamic data from a potential-based panel method equipped with a sheet cavitation model and comparing the noise predictions with those carried out by an alternative numerical approach, documented in literature. It is shown that the proposed formulation yields a one-to-one correlation between emitted noise and sheet cavitation dynamics, carrying out accurate predictions in terms of noise magnitude and directivity.

  19. Viability of calcifying bacterial formulations in fly ash for applications in building materials. (United States)

    Dhami, Navdeep Kaur; Mukherjee, Abhijit; Reddy, M Sudhakara


    Evidence of bacterial involvement in precipitation of calcium carbonates has brought a revolution in the field of applied microbiology, geotechnical sciences, environmental and civil engineering with its marked success in restoration of various building materials. For applications of these calcite binder-producing bacterial cultures, different expensive carrier materials have been used but their high costs have come in the way of their successful commercialization. In the present study, we have explored the potential of cheap industrial by-product fly ash as a carrier material for bacterial cells and investigated the viability of calcifying bacterial isolates: Bacillus megaterium, Bacillus cereus, and Lysinibacillus fusiformis in fly ash carrier at varying temperatures and moisture conditions along with biomineralization efficacy of these formulations. We used laser scanning confocal microscopy to analyze the viability of bacteria by florescent dye 5-cyano-2,3-ditolyl tetrazolium chloride (CTC) along with the plate count method. Results revealed that fly ash successfully served as an effective carrier material and bacterial formulations stored at 4 °C provided longer shelf life than those stored at higher temperatures. Up to 10(6) cfu/g was found to sustain in all formulations at 4 °C compared to 10(4)-10(5) cfu/g in case of higher temperatures up to 1 year. For 4 °C, higher moistures (50 %) were found to provide better survivability while for higher temperatures, lower moistures (30 %) favored higher viability. The biomineralization capability of fresh and formulated bacterial cells was compared on the basis of precipitation of carbonates and it was found that carbonate precipitation efficacy of formulated bacterial cells was comparable to fresh bacterial cells.

  20. Formulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres. (United States)

    Alli, Sk Md Athar


    Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose, a mucoadhesive polymer, following coacervation and phase separation technique and were subsequently enteric-coated with hypromellose phthalate. Microspheres were evaluated for percent yield; entrapment efficiency; in vitro swelling; surface morphology; particle size, size distribution, and zeta potential; flow property, mucoadhesion property by the ex vivo mucoadhesive strength test and the in vitro wash off test; in vitro release profile and release kinetic; in vivo probiotic activity; and stability. The values for the kinetic constant and regression coefficient of model-dependent approaches and the difference factor (f(1)), the similarity factor (f(2)), and the Rescigno index (ξ(1) and ξ(2)) of model independent approaches were determined for comparing in vitro dissolution profiles. Freeze dried B. coagulans cells were successfully formulated as enteric-coated mucoadhesive microspheres with satisfactory physical structure and yield. The viability of B. coagulans was maintained in the simulated gastric conditions and during processing; in simulated intestinal conditions exhibiting mucoadhesion, and controlling and extending the viable cell release following zero-order; and was satisfactorily stable at room temperature. Test results depict statistically significant effects of the hypromellose grade and their concentration on the performance and release profile of formulations.

  1. Fatty acid-based formulations for wood protection against mold and sapstain (United States)

    Carol A. Clausen; Robert D. Coleman; Vina W. Yang


    Safer, highly effective biocides providing long-term protection of mold growth on wood-based materials is of interest to the wood protection industry. Moldicide formulations containing synergistic combinations of ingredients derived from natural sources are commonly recognized as a promising approach for the next generation of wood protectants. Although fatty acid (FA...

  2. A Cultural Approach to Conducting HIV/AIDS and Hepatitis C Virus Education among Native American Adolescents (United States)

    Lowe, John


    This pilot study tests the feasibility of using a Talking Circle approach and measures cultural values and beliefs within a HIV/AIDS and hepatitis C virus (HCV) prevention program conducted among a Native American (Cherokee) youth population. A descriptive correlation design was used to examine the relationship between Cherokee self-reliance and…

  3. Three Approaches to Teaching Art Methods Courses: Child Art, Visual Culture, and Issues-Based Art Education (United States)

    Chang, EunJung; Lim, Maria; Kim, Minam


    In this article, three art educators reflect on their ideas and experiences in developing and implementing innovative projects for their courses focusing on art for elementary education majors. They explore three different approaches. The three areas that are discussed in depth include: (1) understanding child art; (2) visual culture; and (3)…

  4. Culture-independent molecular approaches reveal a mostly unknown high diversity of active nitrogen-fixing bacteria associated with Pennisetum purpureum—a bioenergy crop

    NARCIS (Netherlands)

    Videira, Sandy Sampaio; de Cássia Pereira e Silva, Michele; Galisa, Pericles de Souza; Franco Dias, Armando Cavalcante; Nissinen, Riitta; Baldani Divan, Vera Lucia; van Elsas, Jan Dirk; Baldani, Jose Ivo; Salles, Joana Falcao


    Previous studies have shown that elephant grass is colonized by nitrogen-fixing bacterial species; however, these results were based on culture-dependent methods, an approach that introduces bias due to an incomplete assessment of the microbial community. In this study, we used culture-independent

  5. Cross-culture Communications in Tourism under Conditions of Globalisation

    Directory of Open Access Journals (Sweden)

    Aldoshyna Mariia V.


    Full Text Available The article is devoted to the study of cross-cultural specific features of interaction within social and business communication in the international tourism. The goal of the article is analysis of the cross-cultural environment of Ukraine in the context of the world globalisation for efficient interaction in the sphere of international management and marketing. The article shows a necessity of a study of influence of national cultural features upon business activity of tourist enterprises with consideration of their international and cross-cultural nature of activity. The article identifies functions of culture and presents basic classifications of the world cultures by Geert Hofstede, Fons Trompenaars and Edward Twitchell Hall Jr. It considers specific features of activity of tourist enterprises in the spheres of cross-cultural management and marketing, formulates problems of manifestation of cultural differences in these spheres. It offers main advertising strategies in the international communication policy, which help enterprises to promote their tourist products to international markets more efficiently.

  6. Cultures of Learning and Learning Culture: Socratic and Confucian Approaches to Teaching and Learning (United States)

    Gorry, Jonathan


    A wide variety of British universities are expanding efforts to attract international students. This article argues that higher education's implicit claim to all-inclusive "universality" may hereby be challenged by subsequent issues of cultural particularity. Here I set to conceptualise possible differences in the learning culture of…

  7. A newly high alkaline lipase: an ideal choice for application in detergent formulations

    Directory of Open Access Journals (Sweden)

    Cherif Slim


    Full Text Available Abstract Background Bacterial lipases received much attention for their substrate specificity and their ability to function in extreme environments (pH, temperature.... Many staphylococci produced lipases which were released into the culture medium. Reports of thermostable lipases from Staphylococcus sp. and active in alkaline conditions are not previously described. Results A newly soil-isolated Staphylococcus sp. strain ESW secretes an induced lipase in the culture medium. The effects of temperature, pH and various components in a detergent on the activity and stability of Staphylococcus sp. lipase (SL1 were studied in a preliminary evaluation for use in detergent formulation solutions. The enzyme was highly active over a wide range of pH from 9.0 to 13.0, with an optimum at pH 12.0. The relative activity at pH 13.0 was about 60% of that obtained at pH 12.0. It exhibited maximal activity at 60°C. This novel lipase, showed extreme stability towards non-ionic and anionic surfactants after pre-incubation for 1 h at 40°C, and relative stability towards oxidizing agents. Additionally, the crude enzyme showed excellent stability and compatibility with various commercial solid and liquid detergents. Conclusions These properties added to the high activity in high alkaline pH make this novel lipase an ideal choice for application in detergent formulations.

  8. How to Formulate Marketing and Sales Strategy through Analytical CRM for An Elevator Company


    Teoh, Cheok Hui


    This paper aims to examine how to formulate marketing and sales strategy through analytical Customer Relationship Management (CRM) systems for an elevator company. A multi-layered framework with different perspective of affordance, weighting, interoperability are applied to the culture, people, processes and technology layer as proposed in the framework. Evidence from the case study of Company S suggest that the multi-layered and interdisciplinary framework can assist an elevator company in d...

  9. Deconstructing dementia and delirium hospital practice: using cultural historical activity theory to inform education approaches. (United States)

    Teodorczuk, Andrew; Mukaetova-Ladinska, Elizabeta; Corbett, Sally; Welfare, Mark


    Older patients with dementia and delirium receive suboptimal hospital care. Policy calls for more effective education to address this though there is little consensus on what this entails. The purpose of this clarification study is to explore how practice gaps are constructed in relation to managing the confused hospitalised older patient. The intent is to inform educational processes in the work-place beyond traditional approaches such as training. Adopting grounded theory as a research method and working within a social constructionist paradigm we explored the practice gaps of 15 healthcare professionals by interview and conducted five focus groups with patients, carers and Liaison mental health professionals. Data were thematically analysed by constant comparison and theoretical sampling was undertaken until saturation reached. Categories were identified and pragmatic concepts developed grounded within the data. Findings were then further analysed using cultural historical activity theory as a deductive lens. Practice gaps in relation to managing the confused older patient are determined by factors operating at individual (knowledge and skill gaps, personal philosophy, task based practice), team (leadership, time and ward environmental factors) and organisational (power relationships, dominance of medical model, fragmentation of care services) levels. Conceptually, practice appeared to be influenced by socio-cultural ward factors and compounded by a failure to join up existing "patient" knowledge amongst professionals. Applying cultural historical activity theory to further illuminate the findings, the central object is defined as learning about the patient and the mediating artifacts are the care relationships. The overarching medical dominance emerges as an important cultural historical factor at play and staff rules and divisions of labour are exposed. Lastly key contradictions and tensions in the system that work against learning about the patient are

  10. Should we learn culture in chemistry classroom? Integration ethnochemistry in culturally responsive teaching (United States)

    Rahmawati, Yuli; Ridwan, Achmad; Nurbaity


    The papers report the first year of two-year longitudinal study of ethnochemistry integration in culturally responsive teaching in chemistry classrooms. The teaching approach is focusing on exploring the culture and indigenous knowledge in Indonesia from chemistry perspectives. Ethnochemistry looks at the culture from chemistry perspectives integrated into culturally responsive teaching has developed students' cultural identity and students' engagement in chemistry learning. There are limited research and data in exploring Indonesia culture, which has around 300 ethics, from chemistry perspectives. Students come to the chemistry classrooms from a different background; however, their chemistry learning disconnected with their background which leads to students' disengagement in chemistry learning. Therefore this approach focused on students' engagement within their differences. This research was conducted with year 10 and 11 from four classrooms in two secondary schools through qualitative methodology with observation, interviews, and reflective journals as data collection. The results showed that the integration of ethnochemistry in culturally responsive teaching approach can be implemented by involving 5 principles which are content integration, facilitating knowledge construction, prejudice reduction, social justice, and academic development. The culturally responsive teaching has engaged students in their chemistry learning and developed their cultural identity and soft skills. Students found that the learning experiences has helped to develop their chemistry knowledge and understand the culture from chemistry perspectives. The students developed the ability to work together, responsibility, curiosity, social awareness, creativity, empathy communication, and self-confidence which categorized into collaboration skills, student engagement, social and cultural awareness, and high order thinking skills. The ethnochemistry has helped them to develop the critical self

  11. Evaluating the use of an integrated approach to support energy and climate policy formulation and evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Bassi, A. M. [Millennium Institute, 2111 Wilson Blvd, Suite 700, Arlington, VA 22201 (United States)


    With the adoption of the Kyoto Protocol in 1997 national leaders have started investigating options for reducing carbon emissions within national borders. Despite confronting similar energy issues, every country that adopted the Kyoto Protocol has a unique energy strategy - being characterized by a different context, social, economic or environmental that influences the way different nations deal with climate change and other energy-related issues. Finding that currently available energy models are often too detailed or narrowly focused to inform longer-term policy formulation and evaluation holistically, the present study proposes the utilization of an integrated cross-sectoral medium to longer-term research and modeling approach, incorporating various methodologies to minimize exogenous assumptions and endogenously represent the key drivers of the system analyzed. The framework proposed includes feedback, delays and non-linearity and focuses on structure, scenarios and policies, requires a profound customization of the model that goes beyond a new parameterization. The inclusion of social and environmental factors, in addition to economic ones, all unique to the geographical area analyzed, allows for a wider analysis of the implication of policies by identifying potential side effect or longer-term bottlenecks for socio-economic development and environmental preservation arising from cross-sectoral relations. (author)

  12. Cultural diversity for virtual characters investigating behavioral aspects across cultures

    CERN Document Server

    Endrass, Birgit


    Culture plays a crucial role in our lives. Depending on our cultural background, we judge on and react to everything that we encounter. Subtle differences in behavior can lead to misunderstandings or even culture shock. In a similar manner, virtual characters can be declined by certain user groups when showing culturally inappropriate behavior. But how can social aspects such as culture be integrated into the behavioral models of virtual characters Birgit Endrass addresses this question by carrying out a hybrid approach that is based on theoretical background from the social sciences as well a

  13. National environmental radiation monitoring program: towards formulating policy on radioactive waste management

    International Nuclear Information System (INIS)

    Sukiman Sarmani


    Though Malaysia has no nuclear power station, but the management of its low level radioactive waste generated from industrial activities involves most of the same issues that must be considered in countries with nuclear power. These include public consultation at all stages, an open approach, high level scientific and engineering input and political decision by the Government. A carefully planned approach, which involves the public and gives time to build trust and confidence, is necessary for success. It is also pertinent to establish accurate and reliable data on environmental radiation to accurately assess possible risk. This is where a national monitoring program on environmental radiation is very important. While accurate data will help formulate sound policy on radioactive waste management, it should also be readily available to the public to gain support and acceptance. This paper presents arguments on the importance of a national monitoring program for environmental radiation as an input for formulating a policy on radioactive waste management in Malaysia. (Author)

  14. Triple co-culture cell model as an in vitro model for oral particulate vaccine systems

    DEFF Research Database (Denmark)

    Nielsen, Line Hagner; De Rossi, C.; Lehr, C-M.

    ; this was not observed with ovalbumin and blank solution. An example of the results is shown in Figure 2 for IL-17A. An established co-culture of Caco-2, THP-1 and MUTZ-3 cells showed promise as an in vitro model for testing of oral vaccine formulations. Mobility of co-culture immune cells as well as cytokine production......A triple co-culture cell model of Caco-2 cells, dendritic cells and macrophages (Figure 1) has previously been developed for studying intestinal permeability in a state of inflammation [1],[2]. The aim of this study was to investigate the applicability of this cell model for testing...... the model antigen ovalbumin was spray dried to obtain a particulate vaccine model system for testing in the cell model. The precursors were shown to form cubosomes when dispersed in aqueous medium, and was therefore used as the vaccine formulation for testing on the co-cultures. After 11 days, the TEER...

  15. A hybrid formulation for the numerical simulation of condensed phase explosives (United States)

    Michael, L.; Nikiforakis, N.


    In this article we present a new formulation and an associated numerical algorithm, for the simulation of combustion and transition to detonation of condensed-phase commercial- and military-grade explosives, which are confined by (or in general interacting with one or more) compliant inert materials. Examples include confined rate-stick problems and interaction of shock waves with gas cavities or solid particles in explosives. This formulation is based on an augmented Euler approach to account for the mixture of the explosive and its products, and a multi-phase diffuse interface approach to solve for the immiscible interaction between the mixture and the inert materials, so it is in essence a hybrid (augmented Euler and multi-phase) model. As such, it has many of the desirable features of the two approaches and, critically for our applications of interest, it provides the accurate recovery of temperature fields across all components. Moreover, it conveys a lot more physical information than augmented Euler, without the complexity of full multi-phase Baer-Nunziato-type models or the lack of robustness of augmented Euler models in the presence of more than two components. The model can sustain large density differences across material interfaces without the presence of spurious oscillations in velocity and pressure, and it can accommodate realistic equations of state and arbitrary (pressure- or temperature-based) reaction-rate laws. Under certain conditions, we show that the formulation reduces to well-known augmented Euler or multi-phase models, which have been extensively validated and used in practice. The full hybrid model and its reduced forms are validated against problems with exact (or independently-verified numerical) solutions and evaluated for robustness for rate-stick and shock-induced cavity collapse case-studies.

  16. Formulation of Generic Simulation Models for Analyzing Construction Claims

    Directory of Open Access Journals (Sweden)

    Rifat Rustom


    Full Text Available While there are several techniques for analyzing the impact of claims on time schedule and productivity,very few are considered adequate and comprehensive to consider risks and uncertainties.A generic approach for claims analysis using simulation is proposed. The formulation of the generic methodology presented in this paper depends on three simulation models;As-Planned Model (APM,As-Built Model (ABM, and What-Would-HaveBeenModel(WWHBM. The proposed generic methodology as presented in this paper provides a good basis as a more elaborate approach to better analyze claims and their impacts on project time and productivity utilizing discrete event simulation.The approach proposed allows for scenario analysis to account for the disputed events and workflow disruptions. The proposed models will assist claimants in presenting their cases effectively and professionally.

  17. Wave packet formulation of the boomerang model for resonant electron--molecule scattering

    International Nuclear Information System (INIS)

    McCurdy, C.W.; Turner, J.L.


    A time-dependent formulation of the boomerang model for resonant electron--molecule scattering is presented in terms of a wave packet propagating on the complex potential surface of the metastable anion. The results of calculations using efficient semiclassical techniques for propagating the wave packet are found to be in excellent agreement with full quantum-mechanical calculations of vibrational excitation cross sections in e - --N 2 scattering. The application of the wave packet formulation as a computational and conceptual approach to the problem of resonant collisions with polyatomic molecules is discussed in the light of recent wave packet calculations on polyatomic photodissociation and Raman spectra

  18. A multiherbal formulation influencing immune response in vitro. (United States)

    Menghini, L; Leporini, L; Scanu, N; Pintore, G; Ferrante, C; Recinella, L; Orlando, G; Vacca, M; Brunetti, L


    Aim of this study was to evaluate the effects of phytocomplexes of Uncaria, Shiitake and Ribes in terms of viability and inflammatory response on immune cell-derived cultures. Standardized extracts of Uncaria, Shitake and Ribes and their commercial formulation were tested on cell lines PBMC, U937 and macrophage. The activity was evaluated in terms of cell viability (MTT test), variations of oxidative marker release (ROS and PGE2) and modulatory effects on immune response (gene expression of IL-6, IL-8 and TNFα, RT-PCR). Cell viability was not affected by extracts, except subtle variations observed only at higher doses (>250 µg/mL). The extract mixture was well tolerated, with no effects on cell viability up to doses of 500 µg/mL. Pre-treatment of macrophages with subtoxic doses of the extracts reduced the basal release of oxidative markers and enhanced the cell response to exogenous oxidant stimulation, as revealed by ROS and PGE2 release reduction. The same treatment on macrophage resulted in a selective modulation of the immune response, as shown by an increase of IL-6 mRNA and, partially, IL-8 mRNA, while a reduction was observed for TNFα mRNA. Data confirm that extracts and their formulations can act as regulator of the immune system with mechanisms involving the oxidative stress and the release of selected proinflammatory cytokines.

  19. A quasi-linear formulation for chemically reacting compressible mixtures of imperfect gases (United States)

    Lentini, D.


    A quasi-linear formulation is proposed for high-speed finite-rate chemically reacting mixtures of imperfect gases, i.e., thermally perfect gases with specific heat varying with temperature. It retains the same formalism of a well-tried counterpart formulation for perfect gases, which has been proven to be suited for application of accurate and fast algorithms. Equations for both quasi-monodimensional flows, and for axisymmetric viscous flows are presented. The approach is based on the definition of an appropriate function F of temperature and concentration, which allows to identify Riemann variables for the flow under consideration; the formulation also includes equations for the entropy and the mass fractions of the N chemical species present in the reacting mixture. The key function F must be computed by numerical quadrature, together with its derivatives with respect to the individual species mass fractions. An example of computation of these quantities is reported, with reference to conditions in the combustion chamber of the Vulcain engine powering the first stage of the Ariane 5 launcher. Such a computation is demonstrated to be both economic and accurate, thus proving the workability of the proposed approach. Further, an estimate of the variation of the mixture specific heat ratio with temperature is given, in order to underline the importance of the effect under consideration.

  20. Case Study of An Adopted Chinese Woman with Bulimia Nervosa: A Cultural and Transcultural Approach. (United States)

    de Montgremier, Marion Vu-Augier; Chen, Liangliang; Chen, Jue; Moro, Marie Rose


    For a long time, eating disorders were considered as culture-bound syndromes, specific to Western countries. This theory has been refuted for anorexia, but few transcultural studies have been carried out on bulimia nervosa. As a result, knowledge concerning this disorder is limited. On the basis of a clinical case involving a bulimic Chinese girl, we attempt to demonstrate the impact of cultural factors on the disorder. We discuss the atypical characteristics of her symptom profile, in particular the absence of preoccupations concerning her appearance and the psycho-pathological impact of the secrecy surrounding her adoption. In this particular case, bulimia triggered a search for filiation and identity that could have later enabled her to restore harmonious family ties and to gain autonomy. We also examine the case in the context of adoption in China. This clinical case points out how important it is to take cultural factors into account and how useful a transcultural approach is in order to understand bulimia, and suggest effective methods of care.

  1. Studies of beneficial interactions between active medicaments and excipients in pharmaceutical formulations. (United States)

    Kalinkova, G N


    A review of "up to date" research findings leading to new concepts of the pharmaceutical formulations and their interactions has been presented. The rational approaches to the excipients choice as well as to their interactions with medicaments have been shown as a basis for modern modelling of pharmaceutical formulations. The importance of complexation, hydrogen bonding, ion-dipole, dipole-dipole and van der Waals attractions as the tools which can modify the physicochemical, pharmacological or pharmacokinetical behaviour of the medicaments has been emphasised. In vivo studies (carried out in healthy human subjects-volunteers, in beagle dogs, in rats etc.) and in vitro studies (on excised human skin, hairless mouse skin etc.) as well as studies of chemical stability and bioavailability serve also as a proof of these interactions. Therefore, excipients are important components of pharmaceutical formulations and they can take an active part in the improvement of the characteristics of formulations (but they may also reduce the effectiveness of some preparations). In this context, the so called active and inactive ingredients in pharmaceutical formulations are inexact, old and "out-of date". Their further use is only conventional. In conclusion, among the various modern techniques applied the combination of infrared spectroscopy and X-ray diffraction has been estimated as the most successful in proving the interactions between drugs and excipients. Finally, pharmaceutical formulations and their interactions have constituted a diverse and rapidly expanding field of Pharmacy (Pharmaceutical Technology, Pharmaceutical Industry and Pharmaceutical Sciences) which covers a wide range of numerical topics within an unified framework.

  2. An extension of implicit Monte Carlo diffusion: Multigroup and the difference formulation

    International Nuclear Information System (INIS)

    Cleveland, Mathew A.; Gentile, Nick A.; Palmer, Todd S.


    Implicit Monte Carlo (IMC) and Implicit Monte Carlo Diffusion (IMD) are approaches to the numerical solution of the equations of radiative transfer. IMD was previously derived and numerically tested on grey, or frequency-integrated problems . In this research, we extend Implicit Monte Carlo Diffusion (IMD) to account for frequency dependence, and we implement the difference formulation as a source manipulation variance reduction technique. We derive the relevant probability distributions and present the frequency dependent IMD algorithm, with and without the difference formulation. The IMD code with and without the difference formulation was tested using both grey and frequency dependent benchmark problems. The Su and Olson semi-analytic Marshak wave benchmark was used to demonstrate the validity of the code for grey problems . The Su and Olson semi-analytic picket fence benchmark was used for the frequency dependent problems . The frequency dependent IMD algorithm reproduces the results of both Su and Olson benchmark problems. Frequency group refinement studies indicate that the computational cost of refining the group structure is likely less than that of group refinement in deterministic solutions of the radiation diffusion methods. Our results show that applying the difference formulation to the IMD algorithm can result in an overall increase in the figure of merit for frequency dependent problems. However, the creation of negatively weighted particles from the difference formulation can cause significant numerical instabilities in regions of the problem with sharp spatial gradients in the solution. An adaptive implementation of the difference formulation may be necessary to focus its use in regions that are at or near thermal equilibrium.

  3. Cultural Change: The How and the Why. (United States)

    Varnum, Michael E W; Grossmann, Igor


    More than half a century of cross-cultural research has demonstrated group-level differences in psychological and behavioral phenomena, from values to attention to neural responses. However, cultures are not static, with several specific changes documented for cultural products, practices, and values. How and why do societies change? Here we juxtapose theory and insights from cultural evolution and social ecology. Evolutionary approaches enable an understanding of the how of cultural change, suggesting transmission mechanisms by which the contents of culture may change. Ecological approaches provide insights into the why of cultural change: They identify specific environmental pressures, which evoke shifts in psychology and thereby enable greater precision in predictions of specific cultural changes based on changes in ecological conditions. Complementary insights from the ecological and cultural evolutionary approaches can jointly clarify the process by which cultures change. We end by discussing the relevance of cultural change research for the contemporary societal shifts and by highlighting several critical challenges and future directions for the emerging field of cross-temporal research on culture and psychology.

  4. Understanding Nuclear Safety Culture: A Systemic Approach

    International Nuclear Information System (INIS)

    Afghan, A.N.


    The Fukushima accident was a systemic failure (Report by Director General IAEA on the Fukushima Daiichi Accident). Systemic failure is a failure at system level unlike the currently understood notion which regards it as the failure of component and equipment. Systemic failures are due to the interdependence, complexity and unpredictability within systems and that is why these systems are called complex adaptive systems (CAS), in which “attractors” play an important role. If we want to understand the systemic failures we need to understand CAS and the role of these attractors. The intent of this paper is to identify some typical attractors (including stakeholders) and their role within complex adaptive system. Attractors can be stakeholders, individuals, processes, rules and regulations, SOPs etc., towards which other agents and individuals are attracted. This paper will try to identify attractors in nuclear safety culture and influence of their assumptions on safety culture behavior by taking examples from nuclear industry in Pakistan. For example, if the nuclear regulator is an attractor within nuclear safety culture CAS then how basic assumptions of nuclear plant operators and shift in-charges about “regulator” affect their own safety behavior?

  5. Tactile friction of topical formulations. (United States)

    Skedung, L; Buraczewska-Norin, I; Dawood, N; Rutland, M W; Ringstad, L


    The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Coevolutionary network approach to cultural dynamics controlled by intolerance (United States)

    Gracia-Lázaro, Carlos; Quijandría, Fernando; Hernández, Laura; Floría, Luis Mario; Moreno, Yamir


    Starting from Axelrod's model of cultural dissemination, we introduce a rewiring probability, enabling agents to cut the links with their unfriendly neighbors if their cultural similarity is below a tolerance parameter. For low values of tolerance, rewiring promotes the convergence to a frozen monocultural state. However, intermediate tolerance values prevent rewiring once the network is fragmented, resulting in a multicultural society even for values of initial cultural diversity in which the original Axelrod model reaches globalization.

  7. German Castles, Customs and Culture: Introducing a New Approach to the Undergraduate Culture Course (United States)

    Lalande, John F., II


    Courses on the culture of the German-speaking world (GSW) have long dotted the landscape of undergraduate course offerings at North American colleges and universities. The primary purpose of this article is to share information about a new kind of undergraduate culture course that uses castles as a vehicle for introducing students to past and…

  8. Culture and the social construction of gender: mapping the intersection with mental health. (United States)

    Andermann, Lisa


    The social construction of gender is an important concept for better understanding the determinants of mental health in women and men. Going beyond physical and physiological differences and the traditional biomedical approach, interdisciplinary study of the complex factors related to culture and society, power and politics is necessary to be able to find solutions to situations of disparity in mental health, related to both prevalence of disorders, availability and response to treatment. Gender inequality continues to be a source of suffering for many women around the world, and this can lead to adverse mental health outcomes. This review focuses on developments in the literature on culture, gender and mental health over the past decade, focusing on themes around the social construction of gender, mental health and the media, a look at cultural competence through a gender lens, gender and the body, providing some examples of the intersection between mental health and gender in low-income countries as well as the more developed world, and the impact of migration and resettlement on mental health. At the clinical level, using a bio-psycho-social-spiritual model that can integrate and negotiate between both traditional and biomedical perspectives is necessary, combined with use of a cultural formulation that takes gender identity into account. Research involving both qualitative and quantitative perspectives, and in many cases an ethnographic framework, is essential in tackling these global issues.

  9. Tecfidera(®): an approach for repurposing. (United States)

    Spencer, Roxanne P


    As a case study of patent coverage for a repurposed drug, Biogen Idec's approach for Tecfidera(®), an oral formulation of dimethyl fumarate, was analyzed. While mixtures of fumarates have been used for over 50 years to treat psoriasis, Tecifidera is approved for the treatment of relapsing-remitting multiple sclerosis. Biogen pursued claims to pharmaceutical formulations and useful doses for treating multiple sclerosis, an approach that is relevant to pharmaceutical lifecycle management in general. A survey of recent US, EP, and PCT patent applications indicate other companies are developing competing fumarate formulations. While it is possible to pursue secondary patents for compounds without composition of matter coverage, regulatory data exclusivity provides additional protection to delay competitors.

  10. Chemometric formulation of bacterial consortium-AVS for improved decolorization of resonance-stabilized and heteropolyaromatic dyes. (United States)

    Kumar, Madhava Anil; Kumar, Vaidyanathan Vinoth; Premkumar, Manickam Periyaraman; Baskaralingam, Palanichamy; Thiruvengadaravi, Kadathur Varathachary; Dhanasekaran, Anuradha; Sivanesan, Subramanian


    A bacterial consortium-AVS, consisting of Pseudomonas desmolyticum NCIM 2112, Kocuria rosea MTCC 1532 and Micrococcus glutamicus NCIM 2168 was formulated chemometrically, using the mixture design matrix based on the design of experiments methodology. The formulated consortium-AVS decolorized acid blue 15 and methylene blue with a higher average decolorization rate, which is more rapid than that of the pure cultures. The UV-vis spectrophotometric, Fourier transform infra red spectrophotometric and high performance liquid chromatographic analysis confirm that the decolorization was due to biodegradation by oxido-reductive enzymes, produced by the consortium-AVS. The toxicological assessment of plant growth parameters and the chlorophyll pigment concentrations of Phaseolus mungo and Triticum aestivum seedlings revealed the reduced toxic nature of the biodegraded products. Copyright © 2012 Elsevier Ltd. All rights reserved.

  11. Is Information Ethics Culture-Relative?

    NARCIS (Netherlands)

    Brey, Philip A.E.; Zaphiris, P.; Ang, C.


    In this article, I examine whether information ethics is culture relative. If it is, different approaches to information ethics are required in different cultures and societies. This would have major implications for the current, predominantly Western approach to information ethics. If it is not,

  12. Two anthropological assemblages: New Zealand museums, Native policy, and Māori ‘culture areas’ and ‘adaptation’

    Directory of Open Access Journals (Sweden)

    Fiona Cameron


    Full Text Available In this paper we investigate two anthropological assemblages in Aotearoa/New Zealand in the 1920s and 1930s and how each were used in the adjudication of forms of governmental regulation of Māori populations. We explore the radically different agencements and socio-technical arrangements of people, things and ideas that were formulated within these contexts. Henry Devenish Skinner, curator of the Otago Museum and Anthropology lecturer at the University of Otago, Dunedin, formulated his assemblages based on archaeological fieldwork, ethnology and Wissler’s culture area concept. Indigenous anthropologist Peter Buck and his associates the politicians Āpirana Ngata and Māui Pōmare formulated their distinct assemblages for operating on the Māori social according to living performative culture and anthropological fieldwork. Through these contrasting collecting, fieldwork and ordering regimes, different views of Māori as liberal subjects emerged to articulate ways the Indigenous population could enter into the cultural life of the emerging nation. Indigenous agency was ultimately to become of paramount importance in liberal governance.

  13. Scientific culture: A theoretical approach to the term

    Directory of Open Access Journals (Sweden)

    Rafael Antonio Hernández Cruz Pérez


    Full Text Available Presently article is made a valuation of the term scientific culture starting from a realized systematizing to the records from the term to international level, but with emphasis in the positions assumed by Cuban authors and you culminates with the definition of Scientific Culture of (Pinar 2006. This definition, contrary to those mentioned, explicit the process for the development of the Scientific Culture, having present the Ethics and the historical-social context in its development, for what is not limited alone to the knowledge related with the Science and the Technology. As essential element in this definition the humanist focus is revealed, it is emphasized in the related with the man's development and with its autorrealización that will facilitate them a harmonic bond with the Nature and the Society.

  14. Citizenship and cultural diversity in agenda of cultural policies

    Directory of Open Access Journals (Sweden)

    Patricia Silva Dorneles


    Full Text Available This is a discussion paper which aims to contribute to the systematization of studies, concepts and practices on cultural policies which have been developed in previous years in Brazil and are orienting cultural actions and public programs in the country, also influencing the Occupational Therapy. Citizenship and Cultural Diversity are concepts under construction and are part of the of the agenda of cultural policies and as well as the reflections and practices of various occupational therapists who are acting in a constant dialogue with the cultural area by means of the formation in cultural management, cultural mapping, programs and grant projects aimed to promote inventive identities, traditional communities, native populations, urban mobility, and cultural networks and exchange initiatives, among others. The article presents the process of this conceptual construction and the constitution of experiences aiming the democratization of the culture in the history of Brazilian cultural public policies, over which are being discussed approach paths and possibilities for Occupational Therapy.

  15. In vitro co-cultures of Pinus pinaster with Bursaphelenchus xylophilus: a biotechnological approach to study pine wilt disease. (United States)

    Faria, Jorge M S; Sena, Inês; Vieira da Silva, Inês; Ribeiro, Bruno; Barbosa, Pedro; Ascensão, Lia; Bennett, Richard N; Mota, Manuel; Figueiredo, A Cristina


    Co-cultures of Pinus pinaster with Bursaphelenchus xylophilus were established as a biotechnological tool to evaluate the effect of nematotoxics addition in a host/parasite culture system. The pinewood nematode (PWN), Bursaphelenchus xylophilus, the causal agent of pine wilt disease (PWD), was detected for the first time in Europe in 1999 spreading throughout the pine forests in Portugal and recently in Spain. Plant in vitro cultures may be a useful experimental system to investigate the plant/nematode relationships in loco, thus avoiding the difficulties of field assays. In this study, Pinus pinaster in vitro cultures were established and compared to in vivo 1 year-old plantlets by analyzing shoot structure and volatiles production. In vitro co-cultures were established with the PWN and the effect of the phytoparasite on in vitro shoot structure, water content and volatiles production was evaluated. In vitro shoots showed similar structure and volatiles production to in vivo maritime pine plantlets. The first macroscopic symptoms of PWD were observed about 4 weeks after in vitro co-culture establishment. Nematode population in the culture medium increased and PWNs were detected in gaps of the callus tissue and in cavities developed from the degradation of cambial cells. In terms of volatiles main components, plantlets, P. pinaster cultures, and P. pinaster with B. xylophilus co-cultures were all β- and α-pinene rich. Co-cultures may be an easy-to-handle biotechnological approach to study this pathology, envisioning the understanding of and finding ways to restrain this highly devastating nematode.

  16. Embedding security messages in existing processes: a pragmatic and effective approach to information security culture change

    CERN Document Server

    Lopienski, Sebastian

    Companies and organizations world-wide depend more and more on IT infrastructure and operations. Computer systems store vital information and sensitive data; computing services are essential for main business processes. This high dependency comes with a number of security risks, which have to be managed correctly on technological, organizational and human levels. Addressing the human aspects of information security often boils down just to procedures, training and awareness raising. On the other hand, employees and collaborators do not adopt security attitude and habits simply when told to do so – a real change in behaviour requires an established security culture. But how to introduce a security culture? This thesis outlines the need of developing or improving security culture, and discusses how this can be done. The proposed approach is to gradually build security knowledge and awareness, and influence behaviours. The way to achieve this is to make security communication pervasive by embedding security me...

  17. ALICE's adventures in cultural computing

    NARCIS (Netherlands)

    Hu, J.; Bartneck, C.; Salem, B.I.; Rauterberg, G.W.M.


    In the paradigm of cultural computing, different cultures need different approaches to address the cultural determinants that strongly influences our way of thinking, feeling and worldview in general. For the western culture, our answer to this need is an artistic and interactive installation


    Directory of Open Access Journals (Sweden)

    D'Antoni Maurizia


    Full Text Available Resumen:El ensayo nace como parte de una investigación mayor que se publicará sobre la inserción profesional docente en la Universidad de Costa Rica. Su finalidad en la investigación en curso es la de explorar los aportes de los estudios sobre competencia cultural e inteligencia cultural, para identificar planteamientos teóricos que fortalezcan nuevos espacios para la mediación cultural docente en la Universidad. Se concluye que el concepto de competencia cultural representa un aporte importante, si se revisa la idea de cultura que subyace y se le transforma en “competencia intercultural”. Luego, se define mediación cultural, evidenciándose la importancia de la nueva figura profesional en el contexto actual, los ámbitos de acción donde se ha empleado y se manifiesta la necesidad de promover mediadores y mediadoras culturales en Costa Rica también.Abstract: The essay comes as part of a larger investigation to be published about teachers’ professional integration at the University of Costa Rica. His purpose in the ongoing investigation is to explore the contributions of studies on cultural competency and cultural understanding, to identify new theoretical approaches and strengthen new cultural spaces for teaching mediation at the University. We conclude that the concept of cultural competence represents an important contribution, if we review the underlying idea of culture and it is transformed into "intercultural competence". The definition of cultural mediation points to the importance of the new professional figure in the current context, evidencing the areas of action where it has been used and showing the need to promote cultural mediators in Costa Rica as well.

  19. New Approaches to Attenuated Hepatitis a Vaccine Development: Cloning and Sequencing of Cell-Culture Adapted Viral cDNA. (United States)


    after multiple passages in vivo and in vitro. J. Gen. Virol. 67, 1741- 1744. Sabin , A.B. (1985). Oral poliovirus vaccine : history of its development...IN (N NEW APPROACHES TO ATTENUATED HEPATITIS A VACCINE DEVELOPMENT: Q) CLONING AND SEQUENCING OF CELL-CULTURE ADAPTED VIRAL cDNA I ANNUAL REPORT...6ll02Bsl0 A 055 11. TITLE (Include Security Classification) New Approaches to Attenuated Hepatitis A Vaccine Development: Cloning and Sequencing of Cell

  20. Comparative qualitative research in Cultural Psychology

    DEFF Research Database (Denmark)

    Demuth, Carolin; Fatigante, Marilena


    The present paper aims to provide an approach that allows to study the interplay of culture and psychological human functioning in comparative study designs. Starting out with a brief overview of how qualitative, cultural, and comparative research is addressed in the field of psychology we...... will take a Cultural Psychology approach to suggest that the unit of analysis for comparative research needs to be situated social interaction. We will then suggest an integrative approach that allows us to study social interaction both on a micro- and on a macro-level by combining discourse analysis...... some criteria of validity that particularly apply to the field of comparative research in Cultural Psychology....