A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis.

Science.gov (United States)

Gao, Yi-Qun; Chen, Jiu-Geng; Chen, Zi-Ru; An, Dong; Lv, Qiao-Yan; Han, Mei-Ling; Wang, Ya-Ling; Salt, David E; Chao, Dai-Yin

2017-12-01

Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general.

HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor

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Tsukahara Tomohide

2009-06-01

Full Text Available Abstract Background To develop peptide-based immunotherapy for osteosarcoma, we previously identified papillomavirus binding factor (PBF as a CTL-defined osteosarcoma antigen in the context of HLA-B55. However, clinical application of PBF-based immunotherapy requires identification of naturally presented CTL epitopes in osteosarcoma cells in the context of more common HLA molecules such as HLA-A2. Methods Ten peptides with the HLA-A*0201 binding motif were synthesized from the amino acid sequence of PBF according to the BIMAS score and screened with an HLA class I stabilization assay. The frequency of CTLs recognizing the selected PBF-derived peptide was determined in peripheral blood of five HLA-A*0201+ patients with osteosarcoma using limiting dilution (LD/mixed lymphocyte peptide culture (MLPC followed by tetramer-based frequency analysis. Attempts were made to establish PBF-specific CTL clones from the tetramer-positive CTL pool by a combination of limiting dilution and single-cell sorting. The cytotoxicity of CTLs was assessed by 51Cr release assay. Results Peptide PBF A2.2 showed the highest affinity to HLA-A*0201. CD8+ T cells reacting with the PBF A2.2 peptide were detected in three of five patients at frequencies from 2 × 10-7 to 5 × 10-6. A tetramer-positive PBF A2.2-specific CTL line, 5A9, specifically lysed allogeneic osteosarcoma cell lines that expressed both PBF and either HLA-A*0201 or HLA-A*0206, autologous tumor cells, and T2 pulsed with PBF A2.2. Five of 12 tetramer-positive CTL clones also lysed allogeneic osteosarcoma cell lines expressing both PBF and either HLA-A*0201 or HLA-A*0206 and T2 pulsed with PBF A2.2. Conclusion These findings indicate that PBF A2.2 serves as a CTL epitope on osteosarcoma cells in the context of HLA-A*0201, and potentially, HLA-A*0206. This extends the availability of PBF-derived therapeutic peptide vaccines for patients with osteosarcoma.

Quantifying factors determining the rate of CTL escape and reversion during acute and chronic phases of HIV infection

Energy Technology Data Exchange (ETDEWEB)

Ganusov, Vitaly V [Los Alamos National Laboratory; Korber, Bette M [Los Alamos National Laboratory; Perelson, Alan S [Los Alamos National Laboratory

2009-01-01

Human immunodeficiency virus (HIV) often evades cytotoxic T cell (CTL) responses by generating variants that are not recognized by CTLs. However, the importance and quantitative details of CTL escape in humans are poorly understood. In part, this is because most studies looking at escape of HIV from CTL responses are cross-sectional and are limited to early or chronic phases of the infection. We use a novel technique of single genome amplification (SGA) to identify longitudinal changes in the transmitted/founder virus from the establishment of infection to the viral set point at 1 year after the infection. We find that HIV escapes from virus-specific CTL responses as early as 30-50 days since the infection, and the rates of viral escapes during acute phase of the infection are much higher than was estimated in previous studies. However, even though with time virus acquires additional escape mutations, these late mutations accumulate at a slower rate. A poor correlation between the rate of CTL escape in a particular epitope and the magnitude of the epitope-specific CTL response suggests that the lower rate of late escapes is unlikely due to a low efficacy of the HIV-specific CTL responses in the chronic phase of the infection. Instead, our results suggest that late and slow escapes are likely to arise because of high fitness cost to the viral replication associated with such CTL escapes. Targeting epitopes in which virus escapes slowly or does not escape at all by CTL responses may, therefore, be a promising direction for the development of T cell based HIV vaccines.

Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency.

Science.gov (United States)

Umeshappa, Channakeshava S; Nanjundappa, Roopa H; Xie, Yufeng; Freywald, Andrew; Xu, Qingyong; Xiang, Jim

2013-04-01

Increased CD8(+) T-cell precursor frequency (PF) precludes the requirement of CD4(+) helper T (Th) cells for primary CD8(+) cytotoxic T-lymphocyte (CTL) responses. However, the key questions of whether unhelped CTLs generated at higher PF are functional effectors, and whether unhelped CTLs can differentiate into functional memory cells at higher PF are unclear. In this study, ovalbumin (OVA) -pulsed dendritic cells (DC(OVA)) derived from C57BL/6, CD40 knockout (CD40(-/-)) or CD40 ligand knockout (CD40L(-/-)) mice were used to immunize C57BL/6, Ia(b-/-), CD40(-/-) or CD40L(-/-) mice, whose PF was previously increased with transfer of 1 × 10(6) CD8(+) T cells derived from OVA-specific T-cell receptor (TCR) transgenic OTI, OTI(CD40(-/-)) or OTI(CD40L(-/-)) mice. All the immunized mice were then assessed for effector and memory CTL responses. Following DC immunization, relatively comparable CTL priming occurred without CD4(+) T-cell help and Th-provided CD40/CD40L signalling. In addition, the unhelped CTLs were functional effectors capable of inducing therapeutic immunity against established OVA-expressing tumours. In contrast, the functional memory development of CTLs was severely impaired in the absence of CD4(+) T-cell help and CD40/CD40L signalling. Finally, unhelped memory CTLs failed to protect mice against lethal tumour challenge. Taken together, these results demonstrate that CD4(+) T-cell help at higher PF, is not required for effector CTL priming, but is required for functional memory CTL development against cancer. Our data may impact the development of novel preventive and therapeutic approaches in cancer patients with compromised CD4(+) T-cell functions. © 2012 Blackwell Publishing Ltd.

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL response.

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Ryan M Troyer

2009-04-01

Full Text Available Human lymphocyte antigen (HLA-restricted CD8(+ cytotoxic T lymphocytes (CTL target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escape mutations emerging in seven CTL epitopes in the gp120 Env and p24 Gag coding regions of an individual followed longitudinally from the time of acute HIV-1 infection, as well as some of these same epitopes recognized in other HIV-1-infected individuals. Nine dominant mutations appeared in five gp120 epitopes within the first year of infection, whereas all four mutations found in two p24 epitopes emerged after nearly two years of infection. These mutations were introduced individually into the autologous gene found in acute infection and then placed into a full-length, infectious viral genome. When competed against virus expressing the parental protein, fitness loss was observed with only one of the nine gp120 mutations, whereas four had no effect and three conferred a slight increase in fitness. In contrast, mutations conferring CTL escape in the p24 epitopes significantly decreased viral fitness. One particular escape mutation within a p24 epitope was associated with reduced peptide recognition and high viral fitness costs but was replaced by a fitness-neutral mutation. This mutation appeared to alter epitope processing concomitant with a reduced CTL response. In conclusion, CTL escape mutations in HIV-1 Gag p24 were associated with significant fitness costs, whereas most escape mutations in the Env gene were fitness neutral, suggesting a balance between immunologic escape and replicative fitness costs.

Leukocyte function-associated antigen-1-dependent lysis of Fas+ (CD95+/Apo-1+) innocent bystanders by antigen-specific CD8+ CTL.

Science.gov (United States)

Kojima, H; Eshima, K; Takayama, H; Sitkovsky, M V

1997-09-15

Exquisite specificity toward Ag-bearing cells (cognate targets) is one of the most important properties of CD8+ CTL-mediated cytotoxicity. Using highly Ag-specific CD8+ CTL lines and clones, which spare noncognate, Ag-free targets, we found that in the presence of Ag-bearing targets the CTL acquire the ability to lyse noncognate target cells (bystanders). It is shown that the unexpectedly rapid and efficient lysis of bystanders by Ag-activated CTL is mediated by a Fas ligand (FasL)/Fas-based mechanism and does not depend on perforin. The CTL lysed Fas-expressing bystanders, but spared the Fas-negative or anti-Fas mAb-resistant bystander cells. Accordingly, the FasL-deficient gld/gld CTL did not kill bystanders, while perforin-deficient CTL did. Unlike anti-Fas mAb-induced cell death, the lysis of bystanders was not only FasL/Fas dependent but also required adhesion molecule LFA-1 on the surface of the activated CTL. Lysis of bystanders is viewed as acceptable "collateral" damage, but the persistent presence of activated CTL could result in immunopathologies involving functional Fas-expressing tissues.

Advanced concepts in the United States fusion program

International Nuclear Information System (INIS)

Dove, W.F.

1985-01-01

The goal of the magnetic fusion program is to establish the scientific and technological base for fusion energy. Development of a variety of magnetic confinement systems is essential to achieving that goal. The role of the advanced concepts program is to conduct experimental investigations of confinement concepts other than the tokamaks and tandem mirror concepts. The present advanced concepts program consists of the reversed-field-pinch (RFP), the spheromak and the field-reversed configuration (FRC). Significant new experiments in the RFP and FRC concepts have been approved and are described

Advanced Concept Architecture Design and Integrated Analysis (ACADIA)

Science.gov (United States)

2017-11-03

1 Advanced Concept Architecture Design and Integrated Analysis (ACADIA) Submitted to the National Institute of Aerospace (NIA) on...Research Report 20161001 - 20161030 Advanced Concept Architecture Design and Integrated Analysis (ACADIA) W911NF-16-2-0229 8504Cedric Justin, Youngjun

PERBEDAAN JENIS PEMBELAJARAN MODEL CTL DAN DISCOVERY LEARNING DITINJAU DARI MOTIVASI BELAJAR IPS

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Elpri Darta Putra

2015-06-01

Full Text Available Tujuan penelitian ini adalah menganalisis perbedaan motivasi belajar siswa melalui model pembelajaran Contextual Teaching And Learning, Discovery Learning dan pembelajaran ekspositori. Subjek penelitian ini adalah siswa kelas IV SDN Kuningan 01, SDN Kuningan 04, dan SDN Dadapsari Semarang tahun ajaran 2014/2015. Penelitian dilakukan empat kali pertemuan. Instrumen penelitian ini adalah angket yang berupa butir-butir pernyataan dan lembar wawancara guru. Penelitian ini dalam bentuk penelitian quasi-experimental atau eksperimen semu. Jumlah sampel dalam penelitian ini adalah 85 siswa. Hasil penelitian tentang motivasi belajar siswa di kelas empat menunjukkan bahwa melalui model pembelajaran CTL motivasi belajar siswa dengan nilai rata-rata pada kelas tersebut 81,92 melalui model pembelajaran Discovery Learning 77,66dan melalui pembelajaran ekspositori memiliki rata-rata 52.28. Berdasarkan hasil penelitian tersebut terdapat perbedaan antara motivasi belajar siswa yang menggunakan model pembelajaran CTL, Discovery Learning dan ekspositori, pembelajaran melalui model CTL lebih baik dari pembelajaran melalui model discovery learning dan ekspositrori. The purpose of this study was to analyze differences in student motivation through learning model Contextual Teaching And Learning, Discovery Learning and expository. Subjects in this study were fourth grade students of SDN 01 Brass, Brass SDN 04, and SDN Dadapsari Semarang academic year 2014/2015. The study was conducted four meetings. Data collection instruments in this study was a questionnaire in the form of grains statements and teacher questionnaires. The study is in the form of quasi-experimental or quasi-experimental, the number of samples in this study were 85 students .. The results of students' motivation in the fourth grade showed that through learning model CTL student motivation with the average value in the class 81, 92 through Discovery Learning learning model through expository 77.66 and

The advanced MAPLE reactor concept

International Nuclear Information System (INIS)

Lidstone, R.F.; Lee, A.G.; Gillespie, G.E.; Smith, H.J.

1989-01-01

In Canada the need for advanced neutron sources has long been recognized. During the past several years Atomic Energy of Canada Limited (AECL) has been developing the new MAPLE multipurpose reactor concept. To date, the MAPLE program has focused on the development of a modest-cost multipurpose medium-flux neutron source to meet contemporary requirements for applied and basic research using neutron beams, for small-scale materials testing and analysis and for radioisotope production. The basic MAPLE concept incorporates a compact light-water cooled and moderated core within a heavy water primary reflector to generate strong neutron flux levels in a variety of irradiation facilities. In view of renewed Canadian interest in a high-flux neutron source, the MAPLE group has begun to explore advanced concepts based on AECL's experience with heavy water reactors. The overall objective is to define a high-flux facility that will support materials testing for advanced power reactors, new developments in extracted neutron-beam applications, and/or production of radioisotopes. The design target is to attain performance levels of HFR-Grenoble, HFBR, HFIR in a new heavy water-cooled, -moderated,-reflected reactor based on rodded LEU fuel. Physics, shielding, and thermohydraulic studies have been performed for the MAPLE heavy water reactor. 14 refs., 4 figs., 1 tab

C-type lectin B (SpCTL-B) regulates the expression of antimicrobial peptides and promotes phagocytosis in mud crab Scylla paramamosain.

Science.gov (United States)

Wei, Xiaoyuan; Wang, Limin; Sun, Wanwei; Zhang, Ming; Ma, Hongyu; Zhang, Yueling; Zhang, Xinxu; Li, Shengkang

2018-07-01

As pattern recognition receptors, C-type lectins (CTLs) play important roles in immune system of crustaceans through identifying and binding to the conservative pathogen-associated molecular patterns (PAMPs) on pathogen surfaces. In this study, a new CTL, SpCTL-B, was identified from the hemocytes of mud crab Scylla paramamosain. The full-length of SpCTL-B cDNA was 1278 bp with an open reading frame (ORF) of 348 bp. The predicted SpCTL-B protein contains a single carbohydrate-recognition domain (CRD). SpCTL-B transcripts were distributed in all examined tissues with the highest levels in hepatopancreas. After challenged with Vibrio parahaemolyticus, LPS, polyI:C and white spot syndrome virus (WSSV), the mRNA levels of SpCTL-B in hemocytes and hepatopancreas were up-regulated. The recombinant SpCTL-B (rSpCTL-B) purified by Ni-affinity chromatography showed stronger binding activities with Staphylococcus aureus, β-hemolytic Streptococcus, Escherichia coli, Aeromonas hydrophila, Vibrio alginolyticus than those with V. parahaemolyticus and Saccharomyces cerevisiae. rSpCTL-B exhibited a broad spectrum of microorganism-agglutination activities against Gram-positive bacteria (S. aureus, β-hemolytic Streptococcus) and Gram-negative bacteria (E. coli, V. parahaemolyticus, A. hydrophila, V. alginolyticus) in a Ca 2+ -dependent manner. The agglutination activities of rSpCTL-B could be inhibited by D-mannose and LPS, but not by d-fructose and galactose. The antimicrobial assay showed that rSpCTL-B exhibited the growth inhibition against all examined gram-positive bacteria and gram-negative bacteria. When SpCTL-B was silenced by RNAi, the bacterial clearance ability in mud crab was decreased and the transcript levels of five antimicrobial peptides (AMPs) (SpCrustin, SpHistin, SpALF4 (anti-lipopolysaccharide factor), SpALF5 and SpALF6) were significantly decreased in hemocytes. In our study, knockdown of SpCTL-B could down-regulate the expression of SpSTAT at m

Effect of the CTL proliferation program on virus dynamics

DEFF Research Database (Denmark)

Wodarz, Dominik; Thomsen, Allan Randrup

2005-01-01

Experiments have established that CTLs do not require continuous antigenic stimulation for expansion. Instead, responses develop by a process of programmed proliferation which involves approximately 7-10 antigen-independent cell divisions, the generation of effector cells and the differentiation...... virus loads and thus acute symptoms. The reason is that the programmed divisions are independent from antigenic stimulation, and an increase in virus load does not speed up the rate of CTL expansion. We hypothesize that the 7-10 programmed divisions observed in vivo represent an optimal solution...... into memory cells. The effect of this program on the infection dynamics and the advantages gained by the program have, however, not been explored yet. We investigate this with mathematical models. We find that more programmed divisions can make virus clearance more efficient because CTL division continues...

Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based vector system.

Science.gov (United States)

Han, Seung-Soo; Lee, Jinjoo; Jung, Yideul; Kang, Myeong-Ho; Hong, Jung-Hyub; Cha, Min-Suk; Park, Yu-Jin; Lee, Ezra; Yoon, Cheol-Hee; Bae, Yong-Soo

2015-09-11

We developed a CTL vaccine vector by modification of the RPS-Vax system, a mucosal vaccine vector derived from a poliovirus Sabin 1 strain, and generated an oral CTL vaccine against HIV-1. A DNA fragment encoding a cytoplasmic transduction peptide (CTP) was integrated into the RPS-Vax system to generate RPS-CTP, a CTL vaccine vector. An HIV-1 p24 cDNA fragment was introduced into the RPS-CTP vector system and a recombinant poliovirus (rec-PV) named vRPS-CTP/p24 was produced. vRPS-CTP/p24 was genetically stable and efficiently induced Th1 immunity and p24-specific CTLs in immunized poliovirus receptor-transgenic (PVR-Tg) mice. In challenge experiments, PVR-Tg mice that were pre-immunized orally with vRPS-CTP/p24 were resistant to challenge with a lethal dose of p24-expressing recombinant vaccinia virus (rMVA-p24). These results suggested that the RPS-CTP vector system had potential for developing oral CTL vaccines against infectious diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

Characterization of Gag and Nef-specific ELISpot-based CTL responses in HIV-1 infected Indian individuals.

Science.gov (United States)

Mendiratta, Sanjay; Vajpayee, Madhu; Malhotra, Uma; Kaushik, Shweta; Dar, Lalit; Mojumdar, Kamalika; Chauhan, Neeraj Kumar; Sreenivas, Vishnubhatla

2009-02-01

Cytotoxic T lymphocyte (CTL) responses to Gag have been most frequently linked to control of viremia whereas CTL responses to Nef have direct relationship with viral load. IFN-gamma ELISpot assay was used to screen CTL responses at single peptide level directed at HIV-1 subtype C Gag and Nef proteins in 30 antiretroviral therapy naive HIV-1 infected Indian individuals. PBMCs from 73.3% and 90% of the study population showed response to Gag and Nef antigens, respectively. The magnitude of Gag-specific CTL responses was inversely correlated with plasma viral load (r = -0.45, P = 0.001), whereas magnitude of Nef-specific responses was directly correlated (r = 0.115). Thirteen immunodominant regions (6 in Gag, 7 in Nef) were identified in the current study. The identification of Gag and Nef-specific responses across HIV-1 infected Indian population and targeting epitopes from multiple immunodominant regions may provide useful insight into the designing of new immunotherapy and vaccines.

Chitinase-like (CTL) and cellulose synthase (CESA) gene expression in gelatinous-type cellulosic walls of flax (Linum usitatissimum L.) bast fibers.

Science.gov (United States)

Mokshina, Natalia; Gorshkova, Tatyana; Deyholos, Michael K

2014-01-01

Plant chitinases (EC 3.2.1.14) and chitinase-like (CTL) proteins have diverse functions including cell wall biosynthesis and disease resistance. We analyzed the expression of 34 chitinase and chitinase-like genes of flax (collectively referred to as LusCTLs), belonging to glycoside hydrolase family 19 (GH19). Analysis of the transcript expression patterns of LusCTLs in the stem and other tissues identified three transcripts (LusCTL19, LusCTL20, LusCTL21) that were highly enriched in developing bast fibers, which form cellulose-rich gelatinous-type cell walls. The same three genes had low relative expression in tissues with primary cell walls and in xylem, which forms a xylan type of secondary cell wall. Phylogenetic analysis of the LusCTLs identified a flax-specific sub-group that was not represented in any of other genomes queried. To provide further context for the gene expression analysis, we also conducted phylogenetic and expression analysis of the cellulose synthase (CESA) family genes of flax, and found that expression of secondary wall-type LusCESAs (LusCESA4, LusCESA7 and LusCESA8) was correlated with the expression of two LusCTLs (LusCTL1, LusCTL2) that were the most highly enriched in xylem. The expression of LusCTL19, LusCTL20, and LusCTL21 was not correlated with that of any CESA subgroup. These results defined a distinct type of CTLs that may have novel functions specific to the development of the gelatinous (G-type) cellulosic walls.

Endoplasmic reticulum targeting sequence enhances HBV-specific cytotoxic T lymphocytes induced by a CTL epitope-based DNA vaccine

International Nuclear Information System (INIS)

Xu Wei; Chu Yiwei; Zhang Ruihua; Xu Huanbin; Wang Ying; Xiong Sidong

2005-01-01

CD8 + T cells play a critical role in protective immunity against Hepatitis B Virus (HBV). Epitope-based DNA vaccines expressing HBV-dominant CTL epitopes can be used as candidate vaccines capable of inducing cytotoxic T Lymphocytes (CTL) responses. A plasmid DNA encoding a CTL epitope of HBV core antigen, HBc 18-27 , was constructed. Intramuscular immunization of C57BL/6 mice with this DNA vaccine resulted in successful induction of HBV-specific CTL responses. In order to promote transportation of the peptide into endoplasmic reticulum (ER) to bind to MHC class I molecules for optimal class I antigen presentation, an ER targeting sequence (ERTS) was fused with the C 18-27 encoding gene. ERTS fusion significantly enhanced specific CD8 + T cell responses in terms of CTL cytolysis as well as IFN-γ secretion. This enhancement was correlated with promoted epitope presentation on target cell surface. We report here an enhanced immunogenicity of an epitope-based DNA vaccine using an ER targeting signal sequence, which has significant implications for future design of therapeutic HBV vaccine

Materials technologies for advanced nuclear energy concepts

International Nuclear Information System (INIS)

DiStefano, J.; Harms, B.

1983-01-01

High-performance, advanced nuclear power plant concepts have emerged with major emphasis on lower capital costs, inherent safety, and increased reliability. The materials problems posed by these concepts are discussed and how the scientists and technologists at ORNL plan to solve them is described

CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.

Directory of Open Access Journals (Sweden)

Sylvain Cardinaud

2011-05-01

Full Text Available Cytotoxic CD8+ T cells (CTLs play a critical role in controlling viral infections. HIV-infected individuals develop CTL responses against epitopes derived from viral proteins, but also against cryptic epitopes encoded by viral alternative reading frames (ARF. We studied here the mechanisms of HIV-1 escape from CTLs targeting one such cryptic epitope, Q9VF, encoded by an HIVgag ARF and presented by HLA-B*07. Using PBMCs of HIV-infected patients, we first cloned and sequenced proviral DNA encoding for Q9VF. We identified several polymorphisms with a minority of proviruses encoding at position 5 an aspartic acid (Q9VF/5D and a majority encoding an asparagine (Q9VF/5N. We compared the prevalence of each variant in PBMCs of HLA-B*07+ and HLA-B*07- patients. Proviruses encoding Q9VF/5D were significantly less represented in HLA-B*07+ than in HLA-B*07- patients, suggesting that Q9FV/5D encoding viruses might be under selective pressure in HLA-B*07+ individuals. We thus analyzed ex vivo CTL responses directed against Q9VF/5D and Q9VF/5N. Around 16% of HLA-B*07+ patients exhibited CTL responses targeting Q9VF epitopes. The frequency and the magnitude of CTL responses induced with Q9VF/5D or Q9VF/5N peptides were almost equal indicating a possible cross-reactivity of the same CTLs on the two peptides. We then dissected the cellular mechanisms involved in the presentation of Q9VF variants. As expected, cells infected with HIV strains encoding for Q9VF/5D were recognized by Q9VF/5D-specific CTLs. In contrast, Q9VF/5N-encoding strains were neither recognized by Q9VF/5N- nor by Q9VF/5D-specific CTLs. Using in vitro proteasomal digestions and MS/MS analysis, we demonstrate that the 5N variation introduces a strong proteasomal cleavage site within the epitope, leading to a dramatic reduction of Q9VF epitope production. Our results strongly suggest that HIV-1 escapes CTL surveillance by introducing mutations leading to HIV ARF-epitope destruction by proteasomes.

The advanced MAPLE reactor concept

International Nuclear Information System (INIS)

Lidstone, R.F.; Lee, A.G.; Gillespie, G.E.; Smith, H.J.

1989-01-01

High-flux neutron sources are continuing to be of interest both in Canada and internationally to support materials testing for advanced power reactors, new developments in extracted-neutron-beam applications, and commercial production of selected radioisotopes. The advanced MAPLE reactor concept has been developed to meet these needs. The advanced MAPLE reactor is a new tank-type D 2 O reactor that uses rodded low-enrichment uranium fuel in a compact annular core to generate peak thermal-neutron fluxes of 1 x 10 19 n·s -1 in a central irradiation rig with a thermal power output of 50 MW. Capital and incremental development costs are minimized by using MAPLE reactor technology to the greatest extent practicable

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Science.gov (United States)

Deng, Kai; Pertea, Mihaela; Rongvaux, Anthony; Wang, Leyao; Durand, Christine M.; Ghiaur, Gabriel; Lai, Jun; McHugh, Holly L.; Hao, Haiping; Zhang, Hao; Margolick, Joseph B.; Gurer, Cagan; Murphy, Andrew J.; Valenzuela, David M.; Yancopoulos, George D.; Deeks, Steven G.; Strowig, Till; Kumar, Priti; Siliciano, Janet D.; Salzberg, Steven L.; Flavell, Richard A.; Shan, Liang; Siliciano, Robert F.

2015-01-01

Despite antiretroviral therapy (ART), HIV-1 persists in a stable latent reservoir1, 2, primarily in resting memory CD4+ T cells3, 4. This reservoir presents a major barrier to the cure of HIV-1 infection. To purge the reservoir, pharmacological reactivation of latent HIV-1 has been proposed5 and tested both in vitro and in vivo6–8. A key remaining question is whether virus-specific immune mechanisms including cytolytic T lymphocytes (CTL) can clear infected cells in ART-treated patients after latency is reversed. Here we show that there is a striking all or none pattern for CTL escape mutations in HIV-1 Gag epitopes. Unless ART is started early, the vast majority (>98%) of latent viruses carry CTL escape mutations that render infected cells insensitive to CTLs directed at common epitopes. To solve this problem, we identified CTLs that could recognize epitopes from latent HIV-1 that were unmutated in every chronically infected patient tested. Upon stimulation, these CTLs eliminated target cells infected with autologous virus derived from the latent reservoir, both in vitro and in patient-derived humanized mice. The predominance of CTL-resistant viruses in the latent reservoir poses a major challenge to viral eradication. Our results demonstrate that chronically infected patients retain a broad spectrum viral-specific CTL response and that appropriate boosting of this response may be required for the elimination of the latent reservoir. PMID:25561180

Advanced Fusion Concepts project summaries. FY 1983

International Nuclear Information System (INIS)

1983-06-01

This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, US Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate studients, graduates, other professional staff, and recent publications. The individual project summaries are prepared by the principle investigators in collaboration with the Advanced Fusion Concepts (AFC) Branch. In addition to the project summaries, statements of branch objectives, and budget summaries are also provided

MSFC Advanced Concepts Office and the Iterative Launch Vehicle Concept Method

Science.gov (United States)

Creech, Dennis

2011-01-01

This slide presentation reviews the work of the Advanced Concepts Office (ACO) at Marshall Space Flight Center (MSFC) with particular emphasis on the method used to model launch vehicles using INTegrated ROcket Sizing (INTROS), a modeling system that assists in establishing the launch concept design, and stage sizing, and facilitates the integration of exterior analytic efforts, vehicle architecture studies, and technology and system trades and parameter sensitivities.

ADVANCED HIGH PERFORMANCE SOLID WALL BLANKET CONCEPTS

International Nuclear Information System (INIS)

WONG, CPC; MALANG, S; NISHIO, S; RAFFRAY, R; SAGARA, S

2002-01-01

OAK A271 ADVANCED HIGH PERFORMANCE SOLID WALL BLANKET CONCEPTS. First wall and blanket (FW/blanket) design is a crucial element in the performance and acceptance of a fusion power plant. High temperature structural and breeding materials are needed for high thermal performance. A suitable combination of structural design with the selected materials is necessary for D-T fuel sufficiency. Whenever possible, low afterheat, low chemical reactivity and low activation materials are desired to achieve passive safety and minimize the amount of high-level waste. Of course the selected fusion FW/blanket design will have to match the operational scenarios of high performance plasma. The key characteristics of eight advanced high performance FW/blanket concepts are presented in this paper. Design configurations, performance characteristics, unique advantages and issues are summarized. All reviewed designs can satisfy most of the necessary design goals. For further development, in concert with the advancement in plasma control and scrape off layer physics, additional emphasis will be needed in the areas of first wall coating material selection, design of plasma stabilization coils, consideration of reactor startup and transient events. To validate the projected performance of the advanced FW/blanket concepts the critical element is the need for 14 MeV neutron irradiation facilities for the generation of necessary engineering design data and the prediction of FW/blanket components lifetime and availability

Seminar 'World CTL 2008'

International Nuclear Information System (INIS)

Chevalier, B.

2008-01-01

'Coal to liquid' (CTL) is a well known technic used since years especially by the Germans during the last world war and South Africa during the oil embargo. The combination of coal gasification and Fischer-Tropsch synthesis allows the production of synthetic diesel and gasoline. Nice alternative for those countries with large reserves of coal (China, South Africa, USA) which want to be more 'oil-free' in the long term, it faces however quite a lot of challenges: Very sophisticated technic, not yet proven for large scale of unit, high investment costs, necessity to add up CO 2 capture and storage (CCS) due to climate change constraints... In any cases this process seems more adequate and competitive to produce electricity and power than to focus on transportation fuels which are more easily manufactured from oil. (author)

Advanced fusion concepts project summaries, FY 1988

International Nuclear Information System (INIS)

1988-04-01

This report summarizes all the projects supported by the Advanced Fusion Concepts Branch of the Applied Plasma Physics Division of the Office of Fusion Energy, US Department of Energy. Each project summary was written by the respective principal investigator using the format: title, principal investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications. This report is organized into three sections: Section one contains five summaries describing work in the reversed-field pinch program being performed by a diversified group of contractors, these include a national laboratory, a private company, and several universities. Section two contains eight summaries of work from the compact toroid area which encompasses field-reversed configurations, spheromaks, and heating and formation experiments. Section three contains summaries from two other programs, a density Z-pinch experiment and high-beta Q machine experiment. The intent of this collection of project summaries is to help the contractors of the Advanced Fusion Concepts Branch understand their relationship with the rest of the branch's activities. It is also meant to provide background to those outside the program by showing the range of activities of interest of the Advanced Fusion Concepts Branch

Engineering a CTL-Tailored Replicon RNA Vaccine against PRRSV

DEFF Research Database (Denmark)

Welner, Simon; Werder, Simea; Nielsen, Morten

The development of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV) has been hampered by the high mutation rate and the multiple immunoevasive strategies of the virus. With the overall aim of designing a broad coverage vaccine that induces an effective CTL response aga...... will be available for IVIS. This study exemplifies how bioinformatics epitope prediction, recombinant SLA molecules and RNA virus replicon design can be used to engineer a replicating non-propagating vaccine tailored to deliver conserved and immunogenic CTL epitopes....... against PRRSV, we have used a bioinformatics approach to identify common PRRSV type 2 epitopes predicted to react broadly with predominant swine MHC (SLA) alleles. All possible 9- and 10-mer peptides derived from 104 wild-type strains were analyzed in silico for their predicted binding affinity to 3...... cloned into a classical swine fever virus (CSFV)-derived replicon vector. Virus replicon particles (VRP) were rescued by transfection of a complementing cell line with replicon RNA. Polyepitope expression and subsequent proteasomal degradation was confirmed indirectly by increased FLAG-tagged protein...

Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions.

Science.gov (United States)

Wang, Chuang-Wei; Yang, Lan-Yan; Chen, Chun-Bing; Ho, Hsin-Chun; Hung, Shuen-Iu; Yang, Chih-Hsun; Chang, Chee-Jen; Su, Shih-Chi; Hui, Rosaline Chung-Yee; Chin, See-Wen; Huang, Li-Fang; Lin, Yang Yu-Wei; Chang, Wei-Yang; Fan, Wen-Lang; Yang, Chin-Yi; Ho, Ji-Chen; Chang, Ya-Ching; Lu, Chun-Wei; Chung, Wen-Hung

2018-03-01

Cytotoxic T lymphocyte-mediated (CTL-mediated) severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are rare but life-threatening adverse reactions commonly induced by drugs. Although high levels of CTL-associated cytokines, chemokines, or cytotoxic proteins, including TNF-α and granulysin, were observed in SJS-TEN patients in recent studies, the optimal treatment for these diseases remains controversial. We aimed to evaluate the efficacy, safety, and therapeutic mechanism of a TNF-α antagonist in CTL-mediated SCARs. We enrolled 96 patients with SJS-TEN in a randomized trial to compare the effects of the TNF-α antagonist etanercept versus traditional corticosteroids. Etanercept improved clinical outcomes in patients with SJS-TEN. Etanercept decreased the SCORTEN-based predicted mortality rate (predicted and observed rates, 17.7% and 8.3%, respectively). Compared with corticosteroids, etanercept further reduced the skin-healing time in moderate-to-severe SJS-TEN patients (median time for skin healing was 14 and 19 days for etanercept and corticosteroids, respectively; P = 0.010), with a lower incidence of gastrointestinal hemorrhage in all SJS-TEN patients (2.6% for etanercept and 18.2% for corticosteroids; P = 0.03). In the therapeutic mechanism study, etanercept decreased the TNF-α and granulysin secretions in blister fluids and plasma (45.7%-62.5% decrease after treatment; all P etanercept serves as an effective alternative for the treatment of CTL-mediated SCARs. ClinicalTrials.gov NCT01276314. Ministry of Science and Technology of Taiwan.

IMPLEMENTASI PENDEKATAN CONTEXTUAL TEACHING AND LEARNING (CTL BERBASIS WEB PADA PRAKTIKUM KIMIA

Directory of Open Access Journals (Sweden)

Anggun Zuhaida

2016-11-01

The learning process chemistry in SMA/MA still tends to be a conventional means are still teoritik out the lesson and had yet to develop the ability of students to the maximum. Practical learning can provide an opportunity to students to test and apply the theory by using the facilities of the laboratory and outside the laboratory. This research aims to know the influence of the use of web-based CTL approach towards learning outcomes subject matter the reaction rate. The population in this research is the grade XI IPA in MAN 2 Kudus. Sampling is done using cluster random sampling techniques, namely class XI IPA 4 as a class experiments who got the treatment by using web-based CTL approach and Class XI IPA 5 as a control class get conventional learning with media powerpoint. Method of data collection in this research is a method of documentation, tests, observation and question form. Test hypotheses using the coefficient of biserial correlation and coefficient of determination and acquired rb 0.65 with the amount of contributions 42,11%. The conclusion is the use of web-based CTL influential approach towards learning outcomes subject matter the rate of grade XI IPA MAN 2 Kudus with contributions 42,11%.

An overview of the NASA Advanced Propulsion Concepts program

International Nuclear Information System (INIS)

Curran, F.M.; Bennett, G.L.; Frisbee, R.H.; Sercel, J.C.; Lapointe, M.R.

1992-07-01

NASA Advanced Propulsion Concepts (APC) program for the development of long-term space propulsion system schemes is managed by both NASA-Lewis and the JPL and is tasked with the identification and conceptual development of high-risk/high-payoff configurations. Both theoretical and experimental investigations have been undertaken in technology areas deemed essential to the implementation of candidate concepts. These APC candidates encompass very high energy density chemical propulsion systems, advanced electric propulsion systems, and an antiproton-catalyzed nuclear propulsion concept. A development status evaluation is presented for these systems. 45 refs

A novel C-type lectin from the sea cucumber Apostichopus japonicus (AjCTL-2) with preferential binding of d-galactose.

Science.gov (United States)

Wang, Hui; Xue, Zhuang; Liu, Zhaoqun; Wang, Weilin; Wang, Feifei; Wang, Ying; Wang, Lingling; Song, Linsheng

2018-05-15

C-type lectins (CTLs) are Ca 2+ dependent carbohydrate-binding proteins that share structural homology in their carbohydrate-recognition domains (CRDs). In the present study, a novel CTL was identified from sea cucumber Apostichopus japonicus (named as AjCTL-2). The deduced amino acid sequence of AjCTL-2 was homologous to CTLs from other animals with the identities ranging from 33% to 40%. It contained a canonical signal peptide at the N-terminus, a low density lipoprotein receptor class A (LDLa), a C1r/C1s/Uegf/bone morphogenetic protein 1 (CUB), and a CRD with two motifs Glu-Pro-Asn (EPN) and Trp-Asn-Asp (WND) in Ca 2+ binding site 2. The mRNA transcripts of AjCTL-2 were extensively expressed in all the tested tissues including respiratory tree, muscle, gut, coelomocyte, tube-foot, body wall and gonad, and the highest expression level of AjCTL-2 in coelomocyte was about 4.2-fold (p sea cucumber. Copyright © 2018. Published by Elsevier Ltd.

Advanced composite structural concepts and material technologies for primary aircraft structures

Science.gov (United States)

Jackson, Anthony

1991-01-01

Structural weight savings using advanced composites have been demonstrated for many years. Most military aircraft today use these materials extensively and Europe has taken the lead in their use in commercial aircraft primary structures. A major inhibiter to the use of advanced composites in the United States is cost. Material costs are high and will remain high relative to aluminum. The key therefore lies in the significant reduction in fabrication and assembly costs. The largest cost in most structures today is assembly. As part of the NASA Advanced Composite Technology Program, Lockheed Aeronautical Systems Company has a contract to explore and develop advanced structural and manufacturing concepts using advanced composites for transport aircraft. Wing and fuselage concepts and related trade studies are discussed. These concepts are intended to lower cost and weight through the use of innovative material forms, processes, structural configurations and minimization of parts. The approach to the trade studies and the downselect to the primary wing and fuselage concepts is detailed. The expectations for the development of these concepts is reviewed.

THE EFFECTIVENESS OF CTL MODEL GUIDED INQUIRI-BASED IN THE TOPIC OF CHEMICALS IN DAILY LIFE TO IMPROVE STUDENTS’ LEARNING OUTCOMES AND ACTIVENESS

OpenAIRE

N. R. Fitriani; A. Widiyatmoko; M. Khusniati

2016-01-01

Science learning in school can be applied by connecting the material in the learning with real life. However in fact science learning process in SMP Negeri 10 Magelang has not emphasized students’ activity to relate science to real life. Learning science using CTL guided inquiry-based model implement the learning in where teacher provides initial questions related issues or events in everyday life, then students do experiments to prove concepts of science guided by teacher.The purpose of this...

Local Model Checking of Weighted CTL with Upper-Bound Constraints

DEFF Research Database (Denmark)

Jensen, Jonas Finnemann; Larsen, Kim Guldstrand; Srba, Jiri

2013-01-01

We present a symbolic extension of dependency graphs by Liu and Smolka in order to model-check weighted Kripke structures against the logic CTL with upper-bound weight constraints. Our extension introduces a new type of edges into dependency graphs and lifts the computation of fixed-points from...

Advanced Messaging Concept Development Basic Safety Message

Data.gov (United States)

Department of Transportation — Contains all Basic Safety Messages (BSMs) collected during the Advanced Messaging Concept Development (AMCD) field testing program. For this project, all of the Part...

Mucosal immunization with PLGA-microencapsulated DNA primes a SIV-specific CTL response revealed by boosting with cognate recombinant modified vaccinia virus Ankara

International Nuclear Information System (INIS)

Sharpe, Sally; Hanke, Tomas; Tinsley-Bown, Anne; Dennis, Mike; Dowall, Stuart; McMichael, Andrew; Cranage, Martin

2003-01-01

Systemically administered DNA encoding a recombinant human immunodeficiency virus (HIV) derived immunogen effectively primes a cytotoxic T lymphocyte (CTL) response in macaques. In this further pilot study we have evaluated mucosal delivery of DNA as an alternative priming strategy. Plasmid DNA, pTH.HW, encoding a multi-CTL epitope gene, was incorporated into poly(D,L-lactic-co-glycolic acid) microparticles of less than 10 μm in diameter. Five intrarectal immunizations failed to stimulate a circulating vaccine-specific CTL response in 2 Mamu-A*01 + rhesus macaques. However, 1 week after intradermal immunization with a cognate modified vaccinia virus Ankara vaccine MVA.HW, CTL responses were detected in both animals that persisted until analysis postmortem, 12 weeks after the final boost. In contrast, a weaker and less durable response was seen in an animal vaccinated with the MVA construct alone. Analysis of lymphoid tissues revealed a disseminated CTL response in peripheral and regional lymph nodes but not the spleen of both mucosally primed animals

Review of Advanced Accelerator Concepts R & D in Japan

Science.gov (United States)

Kitagawa, Yoneyoshi; Uesaka, Mitsuru; Koyama, Kazuyoshi; Nakajima, Kaszuhisa; Tajima, Toshiki; Daido, Hiroyuki; Ogata, Atsushi; Nemoto, Koshichi; Nishida, Yasushi; Yugami, Noboru; Miyamoto, Shuji; Dobashi, Katsuhiro

2004-12-01

More than 15 Japanese laboratories are dedicated to the advanced and compact accelerator development. Some use ultra-intense lasers and others use microwave concepts. As for the laser electron accleration, the topics are the capillary acceleration and the mono-energetic acceleration. The laser ion acceleration is also active. As well, the compatization is proceeding of the current rf accelerator. The National Institute for Radiological Science is promoting an advanced accelerator concept project mainly for the medical application.

Advanced High Voltage Power Device Concepts

CERN Document Server

Baliga, B Jayant

2012-01-01

Advanced High Voltage Power Device Concepts describes devices utilized in power transmission and distribution equipment, and for very high power motor control in electric trains and steel-mills. Since these devices must be capable of supporting more than 5000-volts in the blocking mode, this books covers operation of devices rated at 5,000-V, 10,000-V and 20,000-V. Advanced concepts (the MCT, the BRT, and the EST) that enable MOS-gated control of power thyristor structures are described and analyzed in detail. In addition, detailed analyses of the silicon IGBT, as well as the silicon carbide MOSFET and IGBT, are provided for comparison purposes. Throughout the book, analytical models are generated to give a better understanding of the physics of operation for all the structures. This book provides readers with: The first comprehensive treatment of high voltage (over 5000-volts) power devices suitable for the power distribution, traction, and motor-control markets;  Analytical formulations for all the device ...

Identification of novel HLA-A(*)0201-restricted CTL epitopes from Pokemon.

Science.gov (United States)

Yuan, Bangqing; Zhao, Lin; Xian, Ronghua; Zhao, Gang

2012-01-01

Pokemon is a member of the POK family of transcriptional repressors and aberrant overexpressed in various human cancers. Therefore, the related peptide epitopes derived from Pokemon is essential for the development of specific immunotherapy of malignant tumors. In this study, we predicted and identified HLA-A(*)0201-restricted cytotoxic T lymphocyte (CTL) epitopes derived from Pokemon with computer-based epitope prediction, peptide-binding assay and testing of the induced CTLs toward different kinds of carcinoma cells. The results demonstrated that effectors induced by peptides of Pokemon containing residues 32-40, 61-69, 87-95, and 319-327 could specifically secrete IFN-γ and lyse tumor cell lines of Pokemon-positive and HLA-A2-matched. The results suggest that Pokemon32, Pokemon61, Pokemon87, and Pokemon319 peptides are novel HLA-A(*)0201-restricted restricted CTL epitopes, and could be utilized in the cancer immunotherapy against a broad spectrum of tumors. Copyright © 2012 Elsevier Inc. All rights reserved.

Heuristics Applied in the Development of Advanced Space Mission Concepts

Science.gov (United States)

Nilsen, Erik N.

1998-01-01

Advanced mission studies are the first step in determining the feasibility of a given space exploration concept. A space scientist develops a science goal in the exploration of space. This may be a new observation method, a new instrument or a mission concept to explore a solar system body. In order to determine the feasibility of a deep space mission, a concept study is convened to determine the technology needs and estimated cost of performing that mission. Heuristics are one method of defining viable mission and systems architectures that can be assessed for technology readiness and cost. Developing a viable architecture depends to a large extent upon extending the existing body of knowledge, and applying it in new and novel ways. These heuristics have evolved over time to include methods for estimating technical complexity, technology development, cost modeling and mission risk in the unique context of deep space missions. This paper examines the processes involved in performing these advanced concepts studies, and analyzes the application of heuristics in the development of an advanced in-situ planetary mission. The Venus Surface Sample Return mission study provides a context for the examination of the heuristics applied in the development of the mission and systems architecture. This study is illustrative of the effort involved in the initial assessment of an advance mission concept, and the knowledge and tools that are applied.

MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells

Science.gov (United States)

Catalán, Elena; Charni, Seyma; Jaime, Paula; Aguiló, Juan Ignacio; Enríquez, José Antonio; Naval, Javier; Pardo, Julián; Villalba, Martín; Anel, Alberto

2015-01-01

Tumor cells have a tendency to use glucose fermentation to obtain energy instead of mitochondrial oxidative phosphorylation (OXPHOS). We demonstrated that this phenotype correlated with loss of ERK5 expression and with reduced MHC class I expression. Consequently, tumor cells could evade cytotoxic T lymphocyte (CTL)-mediated immune surveillance, but also increase their sensitivity to natural killer (NK) cells. These outcomes were evaluated using two cellular models: leukemic EL4 cells and L929 transformed fibroblasts and their derived ρ° cell lines, which lack mitochondrial DNA. We have also used a L929 cell sub-line that spontaneously lost matrix attachment (L929dt), reminiscent of metastasis generation, that also downregulated MHC-I and ERK5 expression. MHC-I expression is lower in ρ° cells than in the parental cell lines, but they were equally sensitive to CTL. On the contrary, ρ° cells were more sensitive to activated NK cells than parental cells. On the other hand, L929dt cells were resistant to CTL and NK cells, showed reduced viability when forced to perform OXPHOS, and surviving cells increased MHC-I expression and became sensitive to CTL. The present results suggest that when the reduction in MHC-I levels in tumor cells due to glycolytic metabolism is partial, the increase in sensitivity to NK cells seems to predominate. However, when tumor cells completely lose MHC-I expression, the combination of treatments that increase OXPHOS with CTL-mediated immunotherapy could be a promising therapeutic approach. PMID:25949869

MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells.

Science.gov (United States)

Catalán, Elena; Charni, Seyma; Jaime, Paula; Aguiló, Juan Ignacio; Enríquez, José Antonio; Naval, Javier; Pardo, Julián; Villalba, Martín; Anel, Alberto

2015-01-01

Tumor cells have a tendency to use glucose fermentation to obtain energy instead of mitochondrial oxidative phosphorylation (OXPHOS). We demonstrated that this phenotype correlated with loss of ERK5 expression and with reduced MHC class I expression. Consequently, tumor cells could evade cytotoxic T lymphocyte (CTL)-mediated immune surveillance, but also increase their sensitivity to natural killer (NK) cells. These outcomes were evaluated using two cellular models: leukemic EL4 cells and L929 transformed fibroblasts and their derived ρ° cell lines, which lack mitochondrial DNA. We have also used a L929 cell sub-line that spontaneously lost matrix attachment (L929dt), reminiscent of metastasis generation, that also downregulated MHC-I and ERK5 expression. MHC-I expression is lower in ρ° cells than in the parental cell lines, but they were equally sensitive to CTL. On the contrary, ρ° cells were more sensitive to activated NK cells than parental cells. On the other hand, L929dt cells were resistant to CTL and NK cells, showed reduced viability when forced to perform OXPHOS, and surviving cells increased MHC-I expression and became sensitive to CTL. The present results suggest that when the reduction in MHC-I levels in tumor cells due to glycolytic metabolism is partial, the increase in sensitivity to NK cells seems to predominate. However, when tumor cells completely lose MHC-I expression, the combination of treatments that increase OXPHOS with CTL-mediated immunotherapy could be a promising therapeutic approach.

Design and analysis of advanced flight planning concepts

Science.gov (United States)

Sorensen, John A.

1987-01-01

The objectives of this continuing effort are to develop and evaluate new algorithms and advanced concepts for flight management and flight planning. This includes the minimization of fuel or direct operating costs, the integration of the airborne flight management and ground-based flight planning processes, and the enhancement of future traffic management systems design. Flight management (FMS) concepts are for on-board profile computation and steering of transport aircraft in the vertical plane between a city pair and along a given horizontal path. Flight planning (FPS) concepts are for the pre-flight ground based computation of the three-dimensional reference trajectory that connects the city pair and specifies the horizontal path, fuel load, and weather profiles for initializing the FMS. As part of these objectives, a new computer program called EFPLAN has been developed and utilized to study advanced flight planning concepts. EFPLAN represents an experimental version of an FPS. It has been developed to generate reference flight plans compatible as input to an FMS and to provide various options for flight planning research. This report describes EFPLAN and the associated research conducted in its development.

Driving forces and barriers in the development and implementation of coal-to-liquids (CtL) technologies in Germany

International Nuclear Information System (INIS)

Vallentin, Daniel

2008-01-01

Because of a growing global energy demand and rising oil prices coal-abundant nations, such as China and the United States, are pursuing the application of technologies which could replace crude oil imports by converting coal to synthetic hydrocarbon fuels-so-called coal-to-liquids (CtL) technologies. The case of CtL is well suited to analyse techno-economic, resources-related, policy-driven and actor-related parameters, which are affecting the market prospects of a technology that eases energy security constraints but is hardly compatible with a progressive climate policy. This paper concentrates on Germany as an example-the European Union (EU)'s largest member state with considerable coal reserves. It shows that in Germany and the EU, CtL is facing rather unfavourable market conditions as high costs and ambitious climate targets offset its energy security advantage

UPAYA MENGEMBANGKAN LEARNING COMMUNITY SISWA KELAS X SMA MELALUI PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBASIS CTL PADA PEMBELAJARAN FISIKA

Directory of Open Access Journals (Sweden)

Wahyudi -

2012-04-01

Full Text Available Penelitian ini bertujuan untuk mendeskripsikan penerapan model pembelajaran kooperatif tipe STAD berbasis CTL pada pembelajaran fisika dalam mengembangkan learning community dan meningkatkan hasil belajar siswa serta mengetahui dampak penerapannya terhadap learning community dan hasil belajar siswa kelas X-7 SMA N 1 Tahunan Jepara. Hasil penelitian menunjukkan meningkatnya hasil belajar serta berkembangnya learning community siswa kelas X-7 SMA N 1 Tahunan Jepara setelah penerapan model pembelajaran kooperatif tipe STAD berbasis CTL pada pokok bahasan listrik dinamis.This research is describe the implementation of cooperative learning model STAD CTL-based for Physics learning subject to develop learning community, improve students learning and also find out the outcome of its implementation  to the learning community and learning result of SMA N 1 Tahunan Jepara Students class of X-7. The research result shows that there is an improvement of students’ learning result and also a development of learning community of N 1 Tahunan Jepara Students class of X-7 after implementing cooperative learning model STAD CTL-based for Dynamic Electricity topic.

Advanced microwave processing concepts

Energy Technology Data Exchange (ETDEWEB)

Lauf, R.J.; McMillan, A.D.; Paulauskas, F.L. [Oak Ridge National Laboratory, TN (United States)

1995-05-01

The purpose of this work is to explore the feasibility of several advanced microwave processing concepts to develop new energy-efficient materials and processes. The project includes two tasks: (1) commercialization of the variable-frequency microwave furnace; and (2) microwave curing of polymer composites. The variable frequency microwave furnace, whose initial conception and design was funded by the AIC Materials Program, will allow us, for the first time, to conduct microwave processing studies over a wide frequency range. This novel design uses a high-power traveling wave tube (TWT) originally developed for electronic warfare. By using this microwave source, one can not only select individual microwave frequencies for particular experiments, but also achieve uniform power densities over a large area by the superposition of many different frequencies. Microwave curing of thermoset resins will be studied because it hold the potential of in-situ curing of continuous-fiber composites for strong, lightweight components. Microwave heating can shorten curing times, provided issues of scaleup, uniformity, and thermal management can be adequately addressed.

Advanced fusion concepts project summaries: 1981

International Nuclear Information System (INIS)

1982-03-01

This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, US Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications

CTL lysis: there is a hyperbolic relation of killing rate to exocytosable granzyme A for highly cytotoxic murine cytotoxic T lymphocytes.

Science.gov (United States)

Poe, M; Wu, J K; Talento, A; Koo, G C

1996-06-10

The lysis of susceptible targets by efficient cytotoxic T lymphocytes (CTL) increases both with time and with the ratio of CTL to target. Simple methods for calculating a killing rate constant from the time dependence of killing and for calculating the relation of the killing rate constant to the concentration of exocytosable granzyme A are given. Application of these methods to the killing of target cells by the highly efficient mouse CTL AR1 is presented. AR1 needed granzyme A for efficient killing. AR1 contained sufficient exocytosable granzyme A to kill at about 80% of the rate possible at infinite exocytosable granzyme A.

Identification of improvements of advanced light water reactor concepts

International Nuclear Information System (INIS)

Frisch, W.; Liesch, K.; Riegel, B.

1993-01-01

The scope of this report is to identify the improvement of reactor developments with respect to reactor safety. This includes the collection of non-proprietary information on the description of the advanced design characteristics, especially summary design descriptions and general publications. This documentation is not intended to include a safety evaluation of the advanced concepts; however, it is structured in such a way that it can serve as a basis for a future safety evaluation. This is taken into account in the structure of the information regarding the distinction of the various concepts with respect to their 'advancement' and the classification of design characteristics according to some basic safety aspects. The overall description concentrates on those features which are relevant to safety. Other aspects, such as economy, operational features, maintenance, the construction period, etc...are not considered explicitly in this report

The concept of advanced radiographic practice: An international perspective

International Nuclear Information System (INIS)

Hardy, Maryann; Legg, Jeffrey; Smith, Tony; Ween, Borgny; Williams, Imelda; Motto, Jenny

2008-01-01

Advanced radiographic practice has been the focus of much discussion and debate over the last decade, not only in the United Kingdom where advanced practitioner roles are now recognised within the national career framework, but also internationally. Yet, despite almost simultaneous professional movement towards advanced radiographic practice philosophy and ideals in many countries, international collaboration on this development has been minimal. This paper marks a growing international dialogue in this field. It discusses the theoretical concepts of advanced radiographic practice and the development of advanced practitioner roles, incorporating evidence and ideas from differing international perspectives and debates progress towards a potential unified global advanced practice identity

Development of environmentally advanced hydropower turbine system design concepts

Energy Technology Data Exchange (ETDEWEB)

Franke, G.F.; Webb, D.R.; Fisher, R.K. Jr. [Voith Hydro, Inc. (United States)] [and others

1997-08-01

A team worked together on the development of environmentally advanced hydro turbine design concepts to reduce hydropower`s impact on the environment, and to improve the understanding of the technical and environmental issues involved, in particular, with fish survival as a result of their passage through hydro power sites. This approach brought together a turbine design and manufacturing company, biologists, a utility, a consulting engineering firm and a university research facility, in order to benefit from the synergy of diverse disciplines. Through a combination of advanced technology and engineering analyses, innovative design concepts adaptable to both new and existing hydro facilities were developed and are presented. The project was divided into 4 tasks. Task 1 investigated a broad range of environmental issues and how the issues differed throughout the country. Task 2 addressed fish physiology and turbine physics. Task 3 investigated individual design elements needed for the refinement of the three concept families defined in Task 1. Advanced numerical tools for flow simulation in turbines are used to quantify characteristics of flow and pressure fields within turbine water passageways. The issues associated with dissolved oxygen enhancement using turbine aeration are presented. The state of the art and recent advancements of this technology are reviewed. Key elements for applying turbine aeration to improve aquatic habitat are discussed and a review of the procedures for testing of aerating turbines is presented. In Task 4, the results of the Tasks were assembled into three families of design concepts to address the most significant issues defined in Task 1. The results of the work conclude that significant improvements in fish passage survival are achievable.

Development of environmentally advanced hydropower turbine system design concepts

International Nuclear Information System (INIS)

Franke, G.F.; Webb, D.R.; Fisher, R.K. Jr.

1997-08-01

A team worked together on the development of environmentally advanced hydro turbine design concepts to reduce hydropower''s impact on the environment, and to improve the understanding of the technical and environmental issues involved, in particular, with fish survival as a result of their passage through hydro power sites. This approach brought together a turbine design and manufacturing company, biologists, a utility, a consulting engineering firm and a university research facility, in order to benefit from the synergy of diverse disciplines. Through a combination of advanced technology and engineering analyses, innovative design concepts adaptable to both new and existing hydro facilities were developed and are presented. The project was divided into 4 tasks. Task 1 investigated a broad range of environmental issues and how the issues differed throughout the country. Task 2 addressed fish physiology and turbine physics. Task 3 investigated individual design elements needed for the refinement of the three concept families defined in Task 1. Advanced numerical tools for flow simulation in turbines are used to quantify characteristics of flow and pressure fields within turbine water passageways. The issues associated with dissolved oxygen enhancement using turbine aeration are presented. The state of the art and recent advancements of this technology are reviewed. Key elements for applying turbine aeration to improve aquatic habitat are discussed and a review of the procedures for testing of aerating turbines is presented. In Task 4, the results of the Tasks were assembled into three families of design concepts to address the most significant issues defined in Task 1. The results of the work conclude that significant improvements in fish passage survival are achievable

2nd European Advanced Accelerator Concepts Workshop

CERN Document Server

Assmann, Ralph; Grebenyuk, Julia; EAAC 2015

2016-01-01

The European Advanced Accelerator Concepts Workshop has the mission to discuss and foster methods of beam acceleration with gradients beyond state of the art in operational facilities. The most cost effective and compact methods for generating high energy particle beams shall be reviewed and assessed. This includes diagnostics methods, timing technology, special need for injectors, beam matching, beam dynamics with advanced accelerators and development of adequate simulations. This workshop is organized in the context of the EU-funded European Network for Novel Accelerators (EuroNNAc2), that includes 52 Research Institutes and universities.

Advanced high performance solid wall blanket concepts

International Nuclear Information System (INIS)

Wong, C.P.C.; Malang, S.; Nishio, S.; Raffray, R.; Sagara, A.

2002-01-01

First wall and blanket (FW/blanket) design is a crucial element in the performance and acceptance of a fusion power plant. High temperature structural and breeding materials are needed for high thermal performance. A suitable combination of structural design with the selected materials is necessary for D-T fuel sufficiency. Whenever possible, low afterheat, low chemical reactivity and low activation materials are desired to achieve passive safety and minimize the amount of high-level waste. Of course the selected fusion FW/blanket design will have to match the operational scenarios of high performance plasma. The key characteristics of eight advanced high performance FW/blanket concepts are presented in this paper. Design configurations, performance characteristics, unique advantages and issues are summarized. All reviewed designs can satisfy most of the necessary design goals. For further development, in concert with the advancement in plasma control and scrape off layer physics, additional emphasis will be needed in the areas of first wall coating material selection, design of plasma stabilization coils, consideration of reactor startup and transient events. To validate the projected performance of the advanced FW/blanket concepts the critical element is the need for 14 MeV neutron irradiation facilities for the generation of necessary engineering design data and the prediction of FW/blanket components lifetime and availability

Induction of cytotoxic T-cell responses by gene gun DNA vaccination with minigenes encoding influenza A virus HA and NP CTL-epitopes

DEFF Research Database (Denmark)

Fomsgaard, A; Nielsen, H V; Kirkby, N

1999-01-01

degree of controllability. We have examined the induction of murine CTL's by this approach using DNA plasmid minigene vaccines encoding known mouse K(k) minimal CTL epitopes (8 amino acids) from the influenza A virus hemagglutinin and nucleoprotein. We here report that such an approach is feasible...

An Approach for a Synthetic CTL Vaccine Design against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling

Directory of Open Access Journals (Sweden)

Edecio Cunha-Neto

2017-06-01

Full Text Available The threat posed by severe congenital abnormalities related to Zika virus (ZKV infection during pregnancy has turned development of a ZKV vaccine into an emergency. Recent work suggests that the cytotoxic T lymphocyte (CTL response to infection is an important defense mechanism in response to ZKV. Here, we develop the rationale and strategy for a new approach to developing cytotoxic T lymphocyte (CTL vaccines for ZKV flavivirus infection. The proposed approach is based on recent studies using a protein structure computer model for HIV epitope selection designed to select epitopes for CTL attack optimized for viruses that exhibit antigenic drift. Because naturally processed and presented human ZKV T cell epitopes have not yet been described, we identified predicted class I peptide sequences on ZKV matching previously identified DNV (Dengue class I epitopes and by using a Major Histocompatibility Complex (MHC binding prediction tool. A subset of those met the criteria for optimal CD8+ attack based on physical chemistry parameters determined by analysis of the ZKV protein structure encoded in open source Protein Data File (PDB format files. We also identified candidate ZKV epitopes predicted to bind promiscuously to multiple HLA class II molecules that could provide help to the CTL responses. This work suggests that a CTL vaccine for ZKV may be possible even if ZKV exhibits significant antigenic drift. We have previously described a microsphere-based CTL vaccine platform capable of eliciting an immune response for class I epitopes in mice and are currently working toward in vivo testing of class I and class II epitope delivery directed against ZKV epitopes using the same microsphere-based vaccine.

Advanced fusion concepts: project summaries

International Nuclear Information System (INIS)

1980-12-01

This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, US Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications. Information is given for each of the following programs: (1) reverse-field pinch, (2) compact toroid, (3) alternate fuel/multipoles, (4) stellarator/torsatron, (5) linear magnetic fusion, (6) liners, and (7) Tormac

Advanced laser sensing receiver concepts based on FPA technology

International Nuclear Information System (INIS)

Jacobson, Phillip L.; Petrin, Roger R.; Jolin, John L.; Foy, Bernard R.; Lowrance, J.L.; Renda, George

2002-01-01

The ultimate performance of any remote sensor is ideally governed by the hardware signal-to-noise capability and allowed signal-averaging time. In real-world scenarios, this may not be realizable and the limiting factors may suggest the need for more advanced capabilities. Moving from passive to active remote sensors offers the advantage of control over the illumination source, the laser. Added capabilities may include polarization discrimination, instantaneous imaging, range resolution, simultaneous multi-spectral measurement, or coherent detection. However, most advanced detection technology has been engineered heavily towards the straightforward passive sensor requirements, measuring an integrated photon flux. The need for focal plane array technology designed specifically for laser sensing has been recognized for some time, but advances have only recently made the engineering possible. This paper will present a few concepts for laser sensing receiver architectures, the driving specifications behind those concepts, and test/modeling results of such designs.

Advanced storage concepts for solar and low energy buildings, IEA-SHC Task 32. Slutrapport

Energy Technology Data Exchange (ETDEWEB)

Schultz, J.M.; Andersen, Elsa; Furbo, S.

2008-01-15

This report reports on the results of the activities carried through in connection with the Danish part of the IEA SHC Task 32 project: Advanced Storage Concepts for Solar and Low Energy Buildings. The Danish involvement has focused on Subtask C: Storage Concepts Based on Phase Change Materials and Subtask D: Storage Concepts Based on Advanced Water Tanks and Special Devices. The report describes activities concerning heat-of-fusion storage and advanced water storage. (BA)

A Framework for Human Performance Criteria for Advanced Reactor Operational Concepts

Energy Technology Data Exchange (ETDEWEB)

Jacques V Hugo; David I Gertman; Jeffrey C Joe

2014-08-01

This report supports the determination of new Operational Concept models needed in support of the operational design of new reactors. The objective of this research is to establish the technical bases for human performance and human performance criteria frameworks, models, and guidance for operational concepts for advanced reactor designs. The report includes a discussion of operating principles for advanced reactors, the human performance issues and requirements for human performance based upon work domain analysis and current regulatory requirements, and a description of general human performance criteria. The major findings and key observations to date are that there is some operating experience that informs operational concepts for baseline designs for SFR and HGTRs, with the Experimental Breeder Reactor-II (EBR-II) as a best-case predecessor design. This report summarizes the theoretical and operational foundations for the development of a framework and model for human performance criteria that will influence the development of future Operational Concepts. The report also highlights issues associated with advanced reactor design and clarifies and codifies the identified aspects of technology and operating scenarios.

Safety criteria for advanced HTGR concepts

International Nuclear Information System (INIS)

Kroeger, W.

1989-01-01

It is commonly agreed that advanced HTGR concepts must be licensable, which means that they must fulfil existing regulatory requirements. Furthermore, it is necessary to improve their public acceptance and they must even be suitable for urban sites. Therefore, they should be 'safer' than existing plants, which mainly means with respect to low-frequency or beyond-design severe accidents. Last but not least, the realization of advanced HTGR would be easier if commonly shared safety principles could be stated ensuring this further increased level of safety internationally. These qualitative statements need to be cast into quantitative guidelines which can be used as a rationale for safety evaluation. This paper tries to describe the status reached and to stimulate international activities. (author). 12 refs, 4 figs, 3 tabs

Preliminary design concepts of an advanced integral reactor

International Nuclear Information System (INIS)

Moon, Kap S.; Lee, Doo J.; Kim, Keung K.; Chang, Moon H.; Kim, Si H.

1997-01-01

An integral reactor on the basis of PWR technology is being conceptually developed at KAERI. Advanced technologies such as intrinsic and passive safety features are implemented in establishing the design concepts of the reactor to enhance the safety and performance. Research and development including laboratory-scale tests are concurrently underway for confirming the technical adoption of those concepts to the rector design. The power output of the reactor will be in the range of 100MWe to 600MWe which is relatively small compared to the existing loop type reactors. The detailed analysis to assure the design concepts is in progress. (author). 3 figs, 1 tab

Keefektifan Implementasi CTL berbantuan Komik Matematika dan Langkah Penyelesaian Krulik dan Rudnick untuk Meningkatkan Kemampuan Pemahaman dan Disposisi Matematis Siswa

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Christina Widayanti

2017-03-01

Full Text Available This study aims to know the effectiveness of the CTL models aided by mathematical comics and Krulik and Rudnick’s steps in problem solving to improve the ability of student’s mathematical understanding and disposition. Population in this study were VIIIA grade students up to VIIIE of SMP Negeri 1 Pulokulon year 2015/2016 with a true experimental design types posttest­only control design and samples are chosen randomly. Data analysis that used in this study were an average of completeness test, the proportion test, the average difference test, and Mann­Whitney test. The results showed that (1 the ability of student’s mathematical understanding of the subject that have gained CTL models aided by mathematical comics and Krulik and Rudnick’s steps in problem solving have achieved the completeness in groups and classical; (2 the ability of student’s mathematical understanding of students who have gained CTL models aided by mathematical comics and Krulik and Rudnick’s steps in problem solving more than students with expository models aided by LKS, (3 the mathematical disposition of student’s who have gained CTL models aided by mathematical comics and Krulik and Rudnick’s steps in problem solving more than students with expository models aided by LKS.

T-cell receptor (TCR) phenotype of nodal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (CTL): a clinicopathologic study of 39 cases.

Science.gov (United States)

Kato, Seiichi; Asano, Naoko; Miyata-Takata, Tomoko; Takata, Katsuyoshi; Elsayed, Ahmed Ali; Satou, Akira; Takahashi, Emiko; Kinoshita, Tomohiro; Nakamura, Shigeo

2015-04-01

Among Epstein-Barr virus (EBV)-positive cytotoxic T/NK-cell lymphoma, there are only a few reports on the clinicopathologic features of patients with primary nodal presentation (nodal EBV cytotoxic T-cell lymphoma [CTL]). Here, we compared the clinicopathologic profiles of 39 patients with nodal EBV CTL with those of 27 cases of "extranasal" NK/T-cell lymphoma of nasal type (ENKTL), especially addressing their T-cell receptor (TCR) phenotype. Histologically, 22 of 39 nodal EBV CTL cases (56%) were unique in having centroblastoid appearance, which was contrasted with the lower incidence of this feature in ENKTL (15%, P=0.001). In contrast, pleomorphic appearance was more frequently seen in ENKTL than in nodal EBV CTL (67% vs. 23%, P=0.001). Thirty-three of 39 nodal EBV CTL cases (85%) were of T-cell lineage on the basis of TCR expression and/or TCRγ gene rearrangement; in detail, 18 cases (46%) were TCRβ positive (αβ T), 5 (13%) were TCRγ and/or δ positive (γδ T), and 10 (26%) were TCR-silent type with clonal TCRγ gene rearrangement but no expression of TCRβ, γ, or δ. These results were clearly contrasted by a lower incidence of T-cell lineage in ENKTL (7 cases, 26%, P<0.001). Notably, the survival time of the 5 nodal lymphoma patients with γδ T-cell phenotype was within 3 months, which was inferior to those of αβ T and TCR-silent types (P=0.003), and 3 of those with available clinical information were all found to be associated with autoimmune diseases. These data suggest that nodal EBV CTL is distinct from ENKTL.

A mathematical model for CTL effect on a latently infected cell inclusive HIV dynamics and treatment

Science.gov (United States)

Tarfulea, N. E.

2017-10-01

This paper investigates theoretically and numerically the effect of immune effectors, such as the cytotoxic lymphocyte (CTL), in modeling HIV pathogenesis (via a newly developed mathematical model); our results suggest the significant impact of the immune response on the control of the virus during primary infection. Qualitative aspects (including positivity, boundedness, stability, uncertainty, and sensitivity analysis) are addressed. Additionally, by introducing drug therapy, we analyze numerically the model to assess the effect of treatment consisting of a combination of several antiretroviral drugs. Our results show that the inclusion of the CTL compartment produces a higher rebound for an individual's healthy helper T-cell compartment than drug therapy alone. Furthermore, we quantitatively characterize successful drugs or drug combination scenarios.

A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.

Directory of Open Access Journals (Sweden)

Yoshimi Tsuda

2011-08-01

Full Text Available Human outbreaks of Ebola virus (EBOV are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes.We hypothesize that a vaccine strategy using CMV-based vectors expressing EBOV antigens may be ideally suited for use in inaccessible wildlife populations. To establish a 'proof-of-concept' for CMV-based vaccines against EBOV, we constructed a mouse CMV (MCMV vector expressing a CD8+ T cell epitope from the nucleoprotein (NP of Zaire ebolavirus (ZEBOV (MCMV/ZEBOV-NP(CTL. MCMV/ZEBOV-NP(CTL induced high levels of long-lasting (>8 months CD8+ T cells against ZEBOV NP in mice. Importantly, all vaccinated animals were protected against lethal ZEBOV challenge. Low levels of anti-ZEBOV antibodies were only sporadically detected in vaccinated animals prior to ZEBOV challenge suggesting a role, at least in part, for T cells in protection.This study demonstrates the ability of a CMV-based vaccine approach to protect against an highly virulent human pathogen, and supports the potential for 'disseminating' CMV-based EBOV vaccines to prevent EBOV transmission in wildlife populations.

Generation and characterization of peptide-specific, MHC-restricted cytotoxic T lymphocyte (CTL) and helper T cell lines from unprimed T cells under microculture conditions.

Science.gov (United States)

Sambhara, S R; Upadhya, A G; Miller, R G

1990-06-12

We describe a microculture system for the generation of CTL and T helper cells against peptides. Tryptic digest and cyanogen bromide fragments of chicken ovalbumin and synthetic peptides of ovalbumin (323-339) and influenza virus (NP 365-380) were used to generate CTL and T helper lines from unprimed T cells. These lines were both peptide-specific and MHC-restricted. The relative ease of generating peptide-specific, MHC-restricted CTL and helper T cell lines with as few as 10(6) unprimed lymphocytes can be an efficient method of detecting potential immunogenic determinants of an antigen.

Theoretical Investigations of Plasma-Based Accelerators and Other Advanced Accelerator Concepts

International Nuclear Information System (INIS)

Shuets, G.

2004-01-01

Theoretical investigations of plasma-based accelerators and other advanced accelerator concepts. The focus of the work was on the development of plasma based and structure based accelerating concepts, including laser-plasma, plasma channel, and microwave driven plasma accelerators

Advanced Fusion Concepts project summaries, FY 1982

International Nuclear Information System (INIS)

1982-10-01

This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, U.S. Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications

Policy drivers and barriers for coal-to-liquids (CtL) technologies in the United States

International Nuclear Information System (INIS)

Vallentin, Daniel

2008-01-01

Because of a growing dependence on oil imports, powerful industrial, political and societal stakeholders in the United States are trying to enhance national energy security through the conversion of domestic coal into synthetic hydrocarbon liquid fuels-so-called coal-to-liquids (CtL) processes. However, because of the technology's high costs and carbon intensity, its market deployment is strongly affected by the US energy, technology and climate policy setting. This paper analyses and discusses policy drivers and barriers for CtL technologies in the United States and reaches the conclusion that an increasing awareness of global warming among US policy-makers raises the requirements for the technology's environmental performance and, thus, limits its potential to regional niche markets in coal-producing states or strategic markets, such as the military, with specific security and fuel requirements

Generation of cytotoxic T lymphocytes in vitro. VII. Suppressive effect of irradiated MLC cells on CTL response

International Nuclear Information System (INIS)

Fitch, F.W.; Engers, H.D.; Cerottini, J.C.; Bruner, K.T.

1976-01-01

Irradiated cells obtained from MLC at the peak of the CTL response caused profound suppression of generation of CTL when added in small numbers at the initiation of primary MLC prepared with normal spleen cells. The inhibitory activity of the MLC cells was not affected by irradiation (1000 rads) but was abolished by treatment with anti-theta serum and complement. The suppression was immunologically specific. The response of A (H-2/sup a/) spleen cells toward C3H (H-2/sup k/) alloantigens was suppressed by irradiated MLC cells obtained from MLC prepared with A spleen cells and irradiated C3H-stimulating cells, whereas the response of A spleen cells toward DBA/2 (H-2/sup d/) alloantigens was affected relatively little. However, if irradiated C3H x DBA/2F1 hybrid spleen cells were used to stimulate A spleen cells in MLC, addition of irradiated MLC cells having cytotoxic activity toward C3H antigens abolished the response to both C3H and DBA/2 antigens. The response to DBA/2 antigens was much less affected when a mixture of irradiated C3H and DBA/2 spleen cells was used as stimulating cells. Thus, the presence of MLC cells having cytotoxic activity toward one alloantigen abolished the response to another non-cross-reacting antigen only when both antigens were present on the same F1 hybrid-stimulating cells. This suppression of generation of CTL by irradiated MLC cells apparently involves inactivation of alloantigen-bearing stimulating cells as a result of residual cytotoxic activity of the irradiated MLC cells. This mechanism may be active during the decline in CTL activity noted in the normal immune response in vivo and in vitro

PENGARUH PENDEKATAN CONTEXTUAL TEACHING AND LEARNING (CTL BERBANTUAN MEDIA POWERPOINT TERHADAP PENINGKATAN HASIL BELAJAR IPA FISIKA

Directory of Open Access Journals (Sweden)

Suprianto Suprianto

2016-12-01

Full Text Available Berdasarkan hasil wawancara terbatas dengan sebagian guru IPA fisika MTs di kecamatan Camplong Kabupaten Sampang didapatkan informasi bahwa hasil belajar siswa masih rendah dibawah KKM yang sudah ditentukan pihak sekolah. Hal ini disebabkan karena kurangnya penggunaan media pembelajaran, proses pembelajaran masih bersifat teacher centered sehingga sebagian besar siswa tidak mampu menghubungkan antara apa yang mereka pelajari dengan bagaimana pemanfaatannya dalam kehidupan nyata. Adapun tujuan penelitian ini adalah untuk mengidentifikasi pengaruh pendekatan CTL berbantuan media powerpoint terhadap peningkatan hasil belajar IPA fisika siswa. Metode penelitian yang digunakan adalah metode Quasi Experimen dengan menggunakan Nonrandomized Control Group Pretest-Postest Design dan dibagi menjadi dua kelompok, yaitu kelompok eksperimen dan kelompok kontrol. Instrumen penelitian yang digunakan berupa tes objektif bentuk pilihan ganda. Tes ini terdiri dari empat pilihan (opsi dan hasilnya diuji melalui statistik uji “t”. Dari hasil perhitungan diperoleh nilai thitung sebesar 10,81 sedangkan ttabel sebesar 2,021 pada taraf signifikansi 0,05 atau dapat diketahui thitung > ttabel. Dari perhitungan N-gain, dapat dinyatakan bahwa peningkatan hasil belajar fisika yang diterapkan pendekatan CTL berbantuan media powerpoint lebih tinggi dari pada pembelajaran konvensional yaitu 0,71 > 0,52. Berdasarkan hasil analisis statistika dan deskriptif maka dapat di simpulkan bahwa terdapat pengaruh yang signifikan pendekatan CTL berbantuan media powerpoint terhadap peningkatan hasil belajar fisika siswa di kelas VIII MTs.

Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.

Directory of Open Access Journals (Sweden)

Jens Dinter

2015-03-01

Full Text Available Dendritic cells (DCs and macrophages (Møs internalize and process exogenous HIV-derived antigens for cross-presentation by MHC-I to cytotoxic CD8⁺ T cells (CTL. However, how degradation patterns of HIV antigens in the cross-presentation pathways affect immunodominance and immune escape is poorly defined. Here, we studied the processing and cross-presentation of dominant and subdominant HIV-1 Gag-derived epitopes and HLA-restricted mutants by monocyte-derived DCs and Møs. The cross-presentation of HIV proteins by both DCs and Møs led to higher CTL responses specific for immunodominant epitopes. The low CTL responses to subdominant epitopes were increased by pretreatment of target cells with peptidase inhibitors, suggestive of higher intracellular degradation of the corresponding peptides. Using DC and Mø cell extracts as a source of cytosolic, endosomal or lysosomal proteases to degrade long HIV peptides, we identified by mass spectrometry cell-specific and compartment-specific degradation patterns, which favored the production of peptides containing immunodominant epitopes in all compartments. The intracellular stability of optimal HIV-1 epitopes prior to loading onto MHC was highly variable and sequence-dependent in all compartments, and followed CTL hierarchy with immunodominant epitopes presenting higher stability rates. Common HLA-associated mutations in a dominant epitope appearing during acute HIV infection modified the degradation patterns of long HIV peptides, reduced intracellular stability and epitope production in cross-presentation-competent cell compartments, showing that impaired epitope production in the cross-presentation pathway contributes to immune escape. These findings highlight the contribution of degradation patterns in the cross-presentation pathway to HIV immunodominance and provide the first demonstration of immune escape affecting epitope cross-presentation.

ADVANCED SULFUR CONTROL CONCEPTS

Energy Technology Data Exchange (ETDEWEB)

Apostolos A. Nikolopoulos; Santosh K. Gangwal; William J. McMichael; Jeffrey W. Portzer

2003-01-01

Conventional sulfur removal in integrated gasification combined cycle (IGCC) power plants involves numerous steps: COS (carbonyl sulfide) hydrolysis, amine scrubbing/regeneration, Claus process, and tail-gas treatment. Advanced sulfur removal in IGCC systems involves typically the use of zinc oxide-based sorbents. The sulfides sorbent is regenerated using dilute air to produce a dilute SO{sub 2} (sulfur dioxide) tail gas. Under previous contracts the highly effective first generation Direct Sulfur Recovery Process (DSRP) for catalytic reduction of this SO{sub 2} tail gas to elemental sulfur was developed. This process is currently undergoing field-testing. In this project, advanced concepts were evaluated to reduce the number of unit operations in sulfur removal and recovery. Substantial effort was directed towards developing sorbents that could be directly regenerated to elemental sulfur in an Advanced Hot Gas Process (AHGP). Development of this process has been described in detail in Appendices A-F. RTI began the development of the Single-step Sulfur Recovery Process (SSRP) to eliminate the use of sorbents and multiple reactors in sulfur removal and recovery. This process showed promising preliminary results and thus further process development of AHGP was abandoned in favor of SSRP. The SSRP is a direct Claus process that consists of injecting SO{sub 2} directly into the quenched coal gas from a coal gasifier, and reacting the H{sub 2}S-SO{sub 2} mixture over a selective catalyst to both remove and recover sulfur in a single step. The process is conducted at gasifier pressure and 125 to 160 C. The proposed commercial embodiment of the SSRP involves a liquid phase of molten sulfur with dispersed catalyst in a slurry bubble-column reactor (SBCR).

Design concepts and advanced manipulator development for nuclear fuel cycle facilities

International Nuclear Information System (INIS)

Feldman, M.J.

1985-01-01

In the Fuel Recycle Division, Consolidated Fuel Reprocessing Program at the Oak Ridge National Laboratory, a comprehensive remote systems development program has existed for the past seven years. The new remote technology under development is expected to significantly improve remote operations by extending the range of tasks accomplished by remote means and increasing the efficiency of remote work undertaken. The application of advanced manipulation is viewed as an essential part of a series of design directions whose sum describes a somewhat unique blend of old and new technology. A design direction based upon the Teletec concept is explained and recent progress in the development of an advanced servomanipulator-based maintenance concept is summarized to show that a new generation of remote systems is feasible through advanced technology. 14 refs., 14 figs

Advanced remotely maintainable force-reflecting servomanipulator concept

International Nuclear Information System (INIS)

Kuban, D.P.; Martin, H.L.

1984-01-01

A remotely maintainable force-reflecting servomanipulator concept is being developed at the Oak Ridge National Laboratory as part of the Consolidated Fuel Reprocessing Program. This new manipulator addresses requirements of advanced nuclear fuel reprocessing with emphasis on force reflection, remote maintainability, reliability, radiation tolerance, and corrosion resistance. The advanced servomanipulator is uniquely subdivided into remotely replaceable modules which will permit in situ manipulator repair by spare module replacement. Manipulator modularization and increased reliability are accomplished through a force transmission system that uses gears and torque tubes. Digital control algorithms and mechanical precision are used to offset the increased backlash, friction, and inertia resulting from the gear drives. This results in the first remotely maintainable force-reflecting servomanipulator in the world. 10 references, 4 figures, 1 table

Experimentation and evaluation of advanced integrated system concepts

Science.gov (United States)

Ross, M.; Garrigus, K.; Gottschalck, J.; Rinearson, L.; Longee, E.

1980-09-01

This final report examines the implementation of a time-phased test bed for experimentation and evaluation of advanced system concepts relative to the future Defense Switched Network (DSN). After identifying issues pertinent to the DSN, a set of experiments which address these issues are developed. Experiments are ordered based on their immediacy and relative importance to DSN development. The set of experiments thus defined allows requirements for a time phased implementation of a test bed to be identified, and several generic test bed architectures which meet these requirements are examined. Specific architecture implementations are costed and cost/schedule profiles are generated as a function of experimental capability. The final recommended system consists of two separate test beds: a circuit switch test bed, configured around an off-the-shelf commercial switch, and directed toward the examination of nearer term and transitional issues raised by the evolving DSN; and a packet/hybrid test bed, featuring a discrete buildup of new hardware and software modules, and directed toward examination of the more advanced integrated voice and data telecommunications issues and concepts.

Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3′ untranslated region of TRIT1

Directory of Open Access Journals (Sweden)

Rolf K Swoboda

2014-01-01

Full Text Available Noncoding regions of the genome play an important role in tumorigenesis of cancer. Using expression cloning, we have identified a cytotoxic T lymphocyte (CTL–defined antigen that recognizes a protein sequence derived from an open reading frame transcribed from the reverse strand in the 3′ untranslated region of tRNA isopentenyltransferase 1 (TRIT1. A peptide derived from this open reading frame (ORF sequence and predicted to bind to HLA-B57, sensitized HLA-B57+ tumor cells to lysis by CTL793. The peptide also induced a CTL response in peripheral blood mononuclear cells (PBMC of patient 793 and in two other melanoma patients. The CTL lysed peptide-pulsed HLA-B57+ target cells and melanoma cells with endogenous antigen expression. The recognition of this antigen is not limited to HLA-B57-restricted CTLs. An HLA-A2 peptide derived from the ORF was able to induce CTLs in PBMC of 2 HLA-A2+ patients. This study describes for the first time a CTL-defined melanoma antigen that is derived from an ORF on the reverse strand of the putative tumor suppressor gene TRIT1. This antigen has potential use as a vaccine or its ability to induce CTLs in vitro could be used as a predictive biomarker.

An integrative approach to CTL epitope prediction: A combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions

DEFF Research Database (Denmark)

Larsen, Mette Voldby; Lundegaard, Claus; Lamberth, K

2005-01-01

Reverse immunogenetic approaches attempt to optimize the selection of candidate epitopes, and thus minimize the experimental effort needed to identify new epitopes. When predicting cytotoxic T cell epitopes, the main focus has been on the highly specific MHC class I binding event. Methods have al.......The method is available at http://www.cbs.dtu.dk/services/NetCTL. Supplementary material is available at http://www.cbs.dtu.dk/suppl/immunology/CTL.php....

Modified-open fuel cycle performance with breed-and-burn advanced reactor concepts

International Nuclear Information System (INIS)

Heidet, Florent; Kim, Taek K.; Taiwo, Temitope A.

2011-01-01

Recent advances in fast reactor designs enable significant increase in the uranium utilization in an advanced fuel cycle. The category of fast reactors, collectively termed breed-and-burn reactor concepts, can use a large amount of depleted uranium as fuel without requiring enrichment with the exception of the initial core critical loading. Among those advanced concepts, some are foreseen to operate within a once-through fuel cycle such as the Traveling Wave Reactor, CANDLE reactor or Ultra-Long Life Fast Reactor, while others are intended to operate within a modified-open fuel cycle, such as the Breed-and-Burn reactor and the Energy Multiplier Module. This study assesses and compares the performance of the latter category of breed-and-burn reactors at equilibrium state. It is found that the two reactor concepts operating within a modified-open fuel cycle can significantly improve the sustainability and security of the nuclear fuel cycle by decreasing the uranium resources and enrichment requirements even further than the breed-and-burn core concepts operating within the once-through fuel cycle. Their waste characteristics per unit of energy are also found to be favorable, compared to that of currently operating PWRs. However, a number of feasibility issues need to be addressed in order to enable deployment of these breed-and-burn reactor concepts. (author)

Expression, refolding and preliminary X-ray crystallographic analysis of equine MHC class I molecule complexed with an EIAV-Env CTL epitope

International Nuclear Information System (INIS)

Yao, Shugang; Qi, Jianxun; Liu, Jun; Chen, Rong; Pan, Xiaocheng; Li, Xiaoying; Gao, Feng; Xia, Chun

2011-01-01

The equine MHC class I molecule was crystallized in complex with β 2 -microglobulin and a CTL epitope and X-ray diffraction data were collected to 2.3 Å resolution. In order to clarify the structure and the peptide-presentation characteristics of the equine major histocompatibility complex (MHC) class I molecule, a complex of equine MHC class I molecule (ELA-A1 haplotype, 7-6 allele) with mouse β 2 -microglobulin and the cytotoxic T lymphocyte (CTL) epitope Env-RW12 (RVEDVTNTAEYW) derived from equine infectious anaemia virus (EIAV) envelope protein (residues 195–206) was refolded and crystallized. The crystal, which belonged to space group P2 1 , diffracted to 2.3 Å resolution and had unit-cell parameters a = 82.5, b = 71.4, c = 99.8 Å, β = 102.9°. The crystal structure contained two molecules in the asymmetric unit. These results should help to determine the first equine MHC class I molecule structure presenting an EIAV CTL epitope

Core mechanics and configuration behavior of advanced LMFBR core restraint concepts

International Nuclear Information System (INIS)

Fox, J.N.; Wei, B.C.

1978-02-01

Core restraint systems in LMFBRs maintain control of core mechanics and configuration behavior. Core restraint design is complex due to the close spacing between adjacent components, flux and temperature gradients, and irradiation-induced material property effects. Since the core assemblies interact with each other and transmit loads directly to the core restraint structural members, the core assemblies themselves are an integral part of the core restraint system. This paper presents an assessment of several advanced core restraint system and core assembly concepts relative to the expected performance of currently accepted designs. A recommended order for the development of the advanced concepts is also presented

Specialities of the differentiation conditions for the memory cells - either initial or enriched secondary cytotoxic T lymphocyte precursors (pCTL-2) specific to the MHC molecule class 1

International Nuclear Information System (INIS)

Brondz, B.D.; Osipova, T.V.; Aptikaeva, G.F.; Kronin, V.V.

1989-01-01

The in vivo induced pCTL-2 with phenotype L3T4 - Lyt2 + , specific to the H-2K b molecule, turn into effector CTLs during 4 days in the mixed lymphocyte culture (with heat-treated donor stimulators) much more efficiency when donor and recipient are different from one another not only in MHC class 1 (anti-BIO, MBR BIO.AKM) but in 1+2 (K b +1 b ) anti-C57BL/6 BIAD2(R1O1). The initial pCTL-2 differentiation in enhanced as a result of synergistic effect between the K b alloantigen and rIL2. The anti-K b pCTL-2, being separated from helper T cells by means of absorption onto the macrophage donor monolayer and elution from it, give rise to pronounced differentiation in simplified conditions, irrespective of the stimulator presence and without external rIL2. It is supposed that these phenomena are roused to secrection of the CTL differentiation factor by the eluted pCTL-2 themselves, and besides, rIL2 may promote for secretion of this factor additionally

Advanced concept of reduced-moderation water reactor (RMWR) for plutonium multiple recycling

International Nuclear Information System (INIS)

Okubo, T.; Iwamura, T.; Takeda, R.; Yamamoto, K.; Okada, H.

2001-01-01

An advanced water-cooled reactor concept named the Reduced-Moderation Water Reactor (RMWR) has been proposed to attain a high conversion ratio more than 1.0 and to achieve the negative void reactivity coefficient. At present, several types of design concepts satisfying both the design targets have been proposed based on the evaluation for the fuel without fission products and minor actinides. In this paper, the feasibility of the RMWR core is investigated for the plutonium multiple recycling under advanced reprocessing schemes with low decontamination factors as proposed for the FBR fuel cycle. (author)

Penn State advanced light water reactor concept

International Nuclear Information System (INIS)

Borkowski, J.A.; Smith, K.A.; Edwards, R.M.; Robinson, G.E.; Schultz, M.A.; Klevans, E.H.

1987-01-01

The accident at Three Mile Island heightened concerns over the safety of nuclear power. In response to these concerns, a research group at the Pennsylvania State University (Penn State) undertook the conceptual design of an advanced light water reactor (ALWR) under sponsorship of the US Dept. of Energy (DOE). The design builds on the literally hundreds of years worth of experience with light water reactor technology. The concept is a reconfigured pressurized water reactor (PWR) with the capability of being shut down to a safe condition simply by removing all ac power, both off-site and on-site. Using additional passively activated heat sinks and replacing the pressurizer with a pressurizing pump system, the concept essentially eliminates the concerns of core damage associated with a total station blackout. Evaluation of the Penn State ALWR concept has been conducted using the EPRI Modular Modeling System (MMS). Results show that a superior response to normal operating transients can be achieved in comparison to the response with a conventional PWR pressurizer. The DOE-sponsored Penn State ALWR concept has evolved into a significant reconfiguration of a PWR leading to enhanced safety characteristics. The reconfiguration has touched a number of areas in overall plant design including a shutdown turbine in the secondary system, additional passively activated heat sinks, a unique primary side pressurizing concept, a low pressure cleanup system, reactor building layout, and a low power density core design

IMPLEMENTASI CTL DALAM MATA KULIAH PRAKTIKUM METEOROLOGI- KLIMATOLOGI UNTUK MENINGKATKAN KOMPETENSI BEKERJA ILMIAH PADA MAHASISWA JURUSAN PENDIDIKAN GEOGRAFI UNNES

Directory of Open Access Journals (Sweden)

Sriyanto Sriyanto

2014-12-01

Full Text Available The results of self-evaluation Geography Unnes shows that theaverage duration of the study undergraduate Education Studies Geography is more than 4 years. The main causative factor lies in the preparation of the thesis that the time average of more than 12 months. Difficulty in writing his thesis student allegedly because they are not used to working scientific. The concept or practice of law that have been described in the classroom, it seems less able to develop the ability to work ilmiah.Penelitian is done in theDepartment of Geography at the subject of research students department of Geography. Types of research in the form of class action with some procedures or steps to be carried out. These stages are planning, action, observation / evaluation and ends with reflections. The results show the value than lab report results indicate that by using CTL there is an increasein student how scientific work. This is demonstrated by the increasing number of students who are able to work and make a map of rainfall at each cycle a cycle first, 56. 7 still confusion make maps of rainfall with nets Thiesen, only 43.3% were understand and be able to create a map of rainfall is in the second cycle, students are able to create and draw a map of rainfall with jarinng-nets models Thiesen increased to 83.3%. This result has met the completeness criteria that researchers set that is equal to 75% of the total sample / students. This shows that the models and approaches, students CTL capable and able to work scientifically in solving a particular problem in the lecture.

Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm

Science.gov (United States)

Robinson, John W.; McCleskey, Carey M.; Rhodes, Russel E.; Lepsch, Roger A.; Henderson, Edward M.; Joyner, Claude R., III; Levack, Daniel J. H.

2013-01-01

This paper describes Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm. It builds on the work of the previous paper "Approach to an Affordable and Productive Space Transportation System". The scope includes both flight and ground system elements, and focuses on their compatibility and capability to achieve a technical solution that is operationally productive and also affordable. A clear and revolutionary approach, including advanced propulsion systems (advanced LOX rich booster engine concept having independent LOX and fuel cooling systems, thrust augmentation with LOX rich boost and fuel rich operation at altitude), improved vehicle concepts (autogeneous pressurization, turbo alternator for electric power during ascent, hot gases to purge system and keep moisture out), and ground delivery systems, was examined. Previous papers by the authors and other members of the Space Propulsion Synergy Team (SPST) focused on space flight system engineering methods, along with operationally efficient propulsion system concepts and technologies. This paper continues the previous work by exploring the propulsion technology aspects in more depth and how they may enable the vehicle designs from the previous paper. Subsequent papers will explore the vehicle design, the ground support system, and the operations aspects of the new delivery paradigm in greater detail.

Advancing Your Career: Concepts of Professional Nursing. Second Edition.

Science.gov (United States)

Kearney, Rose

This textbook, intended for registered nurses (RN's) returning to school, is designed to provide practicing RN's with professional concepts to advance their careers. The book contains 22 chapters organized in five sections. Each chapter includes chapter objectives, key terms, key points, chapter exercises, references, and a bibliography. Section I…

Eksprimentasi Pembelajaran Kooperatif Tipe Stad dan Tps dengan Pendekatan Ctl pada Materi Pokok Sistem Persamaan Linear Dua Variabel Ditinjau dari Gaya Belajar Siswa

OpenAIRE

Zamroni, Zamroni; Budiyono, Budiyono; Sujadi, Imam

2013-01-01

The objective of research was to find out: (1) which ones having better achievement, the students using TPS (Think Pair Share) learning with CTL approach or STAD (Students Teams Achievement Divisions) cooperative learning model with CTL approach or direct learning, (2) which ones having better learning achievement, the students with kinesthetic or visual or auditory learning style, (3) in each learning style, which ones having better achievement, the students using TPS (Think Pair Share) lear...

Th cells promote CTL survival and memory via acquired pMHC-I and endogenous IL-2 and CD40L signaling and by modulating apoptosis-controlling pathways.

Directory of Open Access Journals (Sweden)

Channakeshava Sokke Umeshappa

Full Text Available Involvement of CD4(+ helper T (Th cells is crucial for CD8(+ cytotoxic T lymphocyte (CTL-mediated immunity. However, CD4(+ Th's signals that govern CTL survival and functional memory are still not completely understood. In this study, we assessed the role of CD4(+ Th cells with acquired antigen-presenting machineries in determining CTL fates. We utilized an adoptive co-transfer into CD4(+ T cell-sufficient or -deficient mice of OTI CTLs and OTII Th cells or Th cells with various gene deficiencies pre-stimulated in vitro by ovalbumin (OVA-pulsed dendritic cell (DCova. CTL survival was kinetically assessed in these mice using FITC-anti-CD8 and PE-H-2K(b/OVA257-264 tetramer staining by flow cytometry. We show that by acting via endogenous CD40L and IL-2, and acquired peptide-MHC-I (pMHC-I complex signaling, CD4(+ Th cells enhance survival of transferred effector CTLs and their differentiation into the functional memory CTLs capable of protecting against highly-metastasizing tumor challenge. Moreover, RT-PCR, flow cytometry and Western blot analysis demonstrate that increased survival of CD4(+ Th cell-helped CTLs is matched with enhanced Akt1/NF-κB activation, down-regulation of TRAIL, and altered expression profiles with up-regulation of prosurvival (Bcl-2 and down-regulation of proapoptotic (Bcl-10, Casp-3, Casp-4, Casp-7 molecules. Taken together, our results reveal a previously unexplored mechanistic role for CD4(+ Th cells in programming CTL survival and memory recall responses. This knowledge could also aid in the development of efficient adoptive CTL cancer therapy.

Th cells promote CTL survival and memory via acquired pMHC-I and endogenous IL-2 and CD40L signaling and by modulating apoptosis-controlling pathways.

Science.gov (United States)

Umeshappa, Channakeshava Sokke; Xie, Yufeng; Xu, Shulin; Nanjundappa, Roopa Hebbandi; Freywald, Andrew; Deng, Yulin; Ma, Hong; Xiang, Jim

2013-01-01

Involvement of CD4(+) helper T (Th) cells is crucial for CD8(+) cytotoxic T lymphocyte (CTL)-mediated immunity. However, CD4(+) Th's signals that govern CTL survival and functional memory are still not completely understood. In this study, we assessed the role of CD4(+) Th cells with acquired antigen-presenting machineries in determining CTL fates. We utilized an adoptive co-transfer into CD4(+) T cell-sufficient or -deficient mice of OTI CTLs and OTII Th cells or Th cells with various gene deficiencies pre-stimulated in vitro by ovalbumin (OVA)-pulsed dendritic cell (DCova). CTL survival was kinetically assessed in these mice using FITC-anti-CD8 and PE-H-2K(b)/OVA257-264 tetramer staining by flow cytometry. We show that by acting via endogenous CD40L and IL-2, and acquired peptide-MHC-I (pMHC-I) complex signaling, CD4(+) Th cells enhance survival of transferred effector CTLs and their differentiation into the functional memory CTLs capable of protecting against highly-metastasizing tumor challenge. Moreover, RT-PCR, flow cytometry and Western blot analysis demonstrate that increased survival of CD4(+) Th cell-helped CTLs is matched with enhanced Akt1/NF-κB activation, down-regulation of TRAIL, and altered expression profiles with up-regulation of prosurvival (Bcl-2) and down-regulation of proapoptotic (Bcl-10, Casp-3, Casp-4, Casp-7) molecules. Taken together, our results reveal a previously unexplored mechanistic role for CD4(+) Th cells in programming CTL survival and memory recall responses. This knowledge could also aid in the development of efficient adoptive CTL cancer therapy.

Introduction to Advanced Engine Control Concepts

Science.gov (United States)

Sanjay, Garg

2007-01-01

With the increased emphasis on aircraft safety, enhanced performance and affordability, and the need to reduce the environmental impact of aircraft, there are many new challenges being faced by the designers of aircraft propulsion systems. The Controls and Dynamics Branch at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet these challenges through the concept of Intelligent Propulsion Systems. The key enabling technologies for an Intelligent Propulsion System are the increased efficiencies of components through active control, advanced diagnostics and prognostics integrated with intelligent engine control to enhance operational reliability and component life, and distributed control with smart sensors and actuators in an adaptive fault tolerant architecture. This presentation describes the current activities of the Controls and Dynamics Branch in the areas of active component control and propulsion system intelligent control, and presents some recent analytical and experimental results in these areas.

Advances in tracking and trigger concepts

International Nuclear Information System (INIS)

Kisel, Ivan

2014-01-01

Increasing beam intensities and input data rates require to rethink the traditional approaches in trigger concepts. At the same time the advanced many-core computer architectures providing new dimensions in programming require to rework the standard methods or to develop new methods of track reconstruction in order to efficiently use parallelism of the computer hardware. As a results a new tendency appears to replace the standard (usually implemented in FPGA) hardware triggers by clusters of computers running software reconstruction and selection algorithms. In addition that makes possible unification of the offline and on-line data processing and analysis in one software package running on a heterogeneous computer farm

Post Landsat-D advanced concept evaluation /PLACE/

Science.gov (United States)

Alexander, L. D.; Alvarado, U. R.; Flatow, F. S.

1979-01-01

The aim of the Post Landsat-D Advanced Concept Evaluation (PLACE) program was to identify the key technology requirements of earth resources satellite systems for the 1985-2000 period. The program involved four efforts: (1) examination of future needs in the earth resources area, (2) creation of a space systems technology model capable of satisfying these needs, (3) identification of key technology requirements posed by this model, and (4) development of a methodology (PRISM) to assist in the priority structuring of the resulting technologies.

Development of a metal-clad advanced composite shear web design concept

Science.gov (United States)

Laakso, J. H.

1974-01-01

An advanced composite web concept was developed for potential application to the Space Shuttle Orbiter main engine thrust structure. The program consisted of design synthesis, analysis, detail design, element testing, and large scale component testing. A concept was sought that offered significant weight saving by the use of Boron/Epoxy (B/E) reinforced titanium plate structure. The desired concept was one that was practical and that utilized metal to efficiently improve structural reliability. The resulting development of a unique titanium-clad B/E shear web design concept is described. Three large scale components were fabricated and tested to demonstrate the performance of the concept: a titanium-clad plus or minus 45 deg B/E web laminate stiffened with vertical B/E reinforced aluminum stiffeners.

Advanced Accelerator Development Strategy Report: DOE Advanced Accelerator Concepts Research Roadmap Workshop

Energy Technology Data Exchange (ETDEWEB)

None, None

2016-02-03

Over a full two day period, February 2–3, 2016, the Office of High Energy Physics convened a workshop in Gaithersburg, MD to seek community input on development of an Advanced Accelerator Concepts (AAC) research roadmap. The workshop was in response to a recommendation by the HEPAP Accelerator R&D Subpanel [1] [2] to “convene the university and laboratory proponents of advanced acceleration concepts to develop R&D roadmaps with a series of milestones and common down selection criteria towards the goal for constructing a multi-TeV e+e– collider” (the charge to the workshop can be found in Appendix A). During the workshop, proponents of laser-driven plasma wakefield acceleration (LWFA), particle-beam-driven plasma wakefield acceleration (PWFA), and dielectric wakefield acceleration (DWFA), along with a limited number of invited university and laboratory experts, presented and critically discussed individual concept roadmaps. The roadmap workshop was preceded by several preparatory workshops. The first day of the workshop featured presentation of three initial individual roadmaps with ample time for discussion. The individual roadmaps covered a time period extending until roughly 2040, with the end date assumed to be roughly appropriate for initial operation of a multi-TeV e+e– collider. The second day of the workshop comprised talks on synergies between the roadmaps and with global efforts, potential early applications, diagnostics needs, simulation needs, and beam issues and challenges related to a collider. During the last half of the day the roadmaps were revisited but with emphasis on the next five to ten years (as specifically requested in the charge) and on common challenges. The workshop concluded with critical and unanimous endorsement of the individual roadmaps and an extended discussion on the characteristics of the common challenges. (For the agenda and list of participants see Appendix B.)

Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes

DEFF Research Database (Denmark)

Pérez, Carina L; Larsen, Mette Voldby; Gustafsson, Rasmus

2008-01-01

The genetic variations of the HIV-1 virus and its human host constitute major obstacles for obtaining potent HIV-1-specific CTL responses in individuals of diverse ethnic backgrounds infected with different HIV-1 variants. In this study, we developed and used a novel algorithm to select 184......, not previously described in the HIV-1 immunology database. In addition, we identified 21 "elite" epitopes that induced CTL responses in at least 4 of the 31 patients. A majority (27 of 31) of the study population recognized one or more of these highly immunogenic epitopes. We also found a limited set of 9...

Integrated environmental control concepts for advanced power systems

International Nuclear Information System (INIS)

Rubin, E.S.; Kalagnanam, J.R.; Berkenpas, M.B.

1996-01-01

For both conventional and advanced power systems, the capability to estimate the performance and cost of environmental control systems is critical to a variety of planning and analysis requirements faced by utilities, regulators, researchers and analysts in the public and private sectors. This paper describes a computer model developed for the U.S. Department of Energy (USDOE) to provide an up-to-date capability for analyzing a variety of pre-combustion, combustion, and post-combustion options in an integrated framework. A unique feature of the model allows performance and costs of integrated environmental control concepts to be modeled probabilistically as a means of characterizing uncertainties and risks. Examples are presented of model applications comparing conventional and advanced emission control designs. 13 refs, 6 figs, 5 tabs

Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

OpenAIRE

Xihui "Paul" Zhang; John D. Crabtree

2015-01-01

Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We present a classic brain teaser that is used to communicate and demonstrate advanced software development concepts and techniques. Our results show th...

Optimalisasi Pembelajaran IPS Pada Siswa Kelas VI Melalui Metode Contextual Teaching And Learning (CTL

Directory of Open Access Journals (Sweden)

Mahfud Mahfud

2014-08-01

Full Text Available Peranan guru dalam pembelajaran IPS mempunyai hubungan erat dengan dengan cara mengaktifkan siswa dalam belajar, terutama dalam proses pengembangan kemampuan dan keterampilan.Untuk mengurangi sifat verbalisme siswa dan membantah pemahaman konsep yang terdapat dalam materi IPS yang terdapat di SD, guru diharapkan memiliki kemampuan untuk mengembangkan model interaktif dalam pembelajaran IPS serta mengidentifikasi sumber-sumber pelajaran. Salah satu model interaktif yang bisa diterapkan guru salah satunya adalah model pembelajaran kontekstual atau Contextual Teaching and Learning (CTL. Pembelajarn kontekstual merupakan suatu proses yang bertujuan untuk membantu siswa memahami materi pelajaran yang sedang mereka pelajari dengan menghubungkan pokok materi pelajaran dengan penerapannya dalam kehidupan sehari-hari.Dari hasil kegiatan penelitian tindakan kelas yang telah dilakukan dalam dua siklus terhadap siswa kelas VIA di SDN Pinggir Papas 1 Kecamatan Kalianget Kabupaten Sumenep, dan berdasarkan seluruh pembahasan dari hasil analisis yang telah dilakukan, dapat disimpulkan bahwaOptimalisasi Pembelajaran IPS pada Siswa Kelas VIAmelalui Metode Contextual Teaching And Learning(CTL dapat meningkatkan kemampuan siswa memahami materi pembelajaran IPS, sehingga berpengaruh terhadap peningkatan prestasi belajar siswa, serta siswa menjadi aktif dan tertarik mengikuti proses pembelajaranyang dilaksanakan oleh guru di kelas.

Calculation methods for advanced concept light water reactor lattices

International Nuclear Information System (INIS)

Carmona, S.

1986-01-01

In the last few years s several advanced concepts for fuel rod lattices have been studied. Improved fuel utilization is one of the major aims in the development of new fuel rod designs and lattice modifications. By these changes s better performance in fuel economics s fuel burnup and material endurance can be achieved in the frame of the well-known basic Light Water Reactor technology. Among the new concepts involved in these studies that have attracted serious attention are lattices consisting of arrays of annular rods duplex pellet rods or tight multicells. These new designs of fuel rods and lattices present several computational problems. The treatment of resonance shielded cross sections is a crucial point in the analyses of these advanced concepts . The purpose of this study was to assess adequate approximation methods for calculating as accurately as possible, resonance shielding for these new lattices. Although detailed and exact computational methods for the evaluation of the resonance shielding in these lattices are possible, they are quite inefficient when used in lattice codes. The computer time and memory required for this kind of computations are too large to be used in an acceptable routine manner. In order to over- come these limitations and to make the analyses possible with reasonable use of computer resources s approximation methods are necessary. Usual approximation methods, for the resonance energy regions used in routine lattice computer codes, can not adequately handle the evaluation of these new fuel rod lattices. The main contribution of the present work to advanced lattice concepts is the development of an equivalence principle for the calculation of resonance shielding in the annular fuel pellet zone of duplex pellets; the duplex pellet in this treatment consists of two fuel zones with the same absorber isotope in both regions. In the transition from a single duplex rod to an infinite array of this kind of fuel rods, the similarity of the

An iLab for Teaching Advanced Logic Concepts with Hardware Descriptive Languages

Science.gov (United States)

Ayodele, Kayode P.; Inyang, Isaac A.; Kehinde, Lawrence O.

2015-01-01

One of the more interesting approaches to teaching advanced logic concepts is the use of online laboratory frameworks to provide student access to remote field-programmable devices. There is as yet, however, no conclusive evidence of the effectiveness of such an approach. This paper presents the Advanced Digital Lab, a remote laboratory based on…

Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques.

Directory of Open Access Journals (Sweden)

Thomas H Vanderford

2011-05-01

Full Text Available SIV(mac239 infection of rhesus macaques (RMs results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV mutants, we longitudinally assessed the presence of CTL escape variants in two MamuA*01-restricted immunodominant epitopes (Tat-SL8 and Gag-CM9 in the plasma, PBMCs, lymph nodes (LN, and rectal biopsies (RB of fifteen SIV(mac239-infected RMs. As expected, Gag-CM9 did not exhibit signs of escape before day 84 post infection. In contrast, Tat-SL8 escape mutants were apparent in all tissues by day 14 post infection. Interestingly LNs and plasma exhibited the highest level of escape at day 14 and day 28 post infection, respectively, with the rate of escape in the RB remaining lower throughout the acute infection. The possibility that CTL escape occurs in LNs before RBs is confirmed by the observation that the specific mutants found at high frequency in LNs at day 14 post infection became dominant at day 28 post infection in plasma, PBMC, and RB. Finally, the frequency of escape mutants in plasma at day 28 post infection correlated strongly with the level Tat-SL8-specific CD8 T cells in the LN and PBMC at day 14 post infection. These results indicate that LNs represent the primary source of CTL escape mutants during the acute phase of SIV(mac239 infection, suggesting that LNs are the main anatomic sites of virus replication and/or the tissues in which CTL pressure is most effective in selecting SIV escape variants.

Peptide-MHC class I stability is a stronger predictor of CTL immunogenicity than peptide affinity

DEFF Research Database (Denmark)

Harndahl, Mikkel Nors; Rasmussen, Michael; Nielsen, Morten

2012-01-01

Peptide-MHC class I stability is a stronger predictor of CTL immunogenicity than peptide affinity Mikkel Harndahla, Michael Rasmussena, Morten Nielsenb, Soren Buusa,∗ a Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Denmark b Center for Biological Seq...... al., 2007. J. Immunol. 178, 7890–7901. doi:10.1016/j.molimm.2012.02.025...

NASA Advanced Concepts Office, Earth-To-Orbit Team Design Process and Tools

Science.gov (United States)

Waters, Eric D.; Garcia, Jessica; Threet, Grady E., Jr.; Phillips, Alan

2013-01-01

The Earth-to-Orbit Team (ETO) of the Advanced Concepts Office (ACO) at NASA Marshall Space Flight Center (MSFC) is considered the pre-eminent "go-to" group for pre-phase A and phase A concept definition. Over the past several years the ETO team has evaluated thousands of launch vehicle concept variations for a significant number of studies including agency-wide efforts such as the Exploration Systems Architecture Study (ESAS), Constellation, Heavy Lift Launch Vehicle (HLLV), Augustine Report, Heavy Lift Propulsion Technology (HLPT), Human Exploration Framework Team (HEFT), and Space Launch System (SLS). The ACO ETO Team is called upon to address many needs in NASA's design community; some of these are defining extremely large trade-spaces, evaluating advanced technology concepts which have not been addressed by a large majority of the aerospace community, and the rapid turn-around of highly time critical actions. It is the time critical actions, those often limited by schedule or little advanced warning, that have forced the five member ETO team to develop a design process robust enough to handle their current output level in order to meet their customer's needs. Based on the number of vehicle concepts evaluated over the past year this output level averages to four completed vehicle concepts per day. Each of these completed vehicle concepts includes a full mass breakdown of the vehicle to a tertiary level of subsystem components and a vehicle trajectory analysis to determine optimized payload delivery to specified orbital parameters, flight environments, and delta v capability. A structural analysis of the vehicle to determine flight loads based on the trajectory output, material properties, and geometry of the concept is also performed. Due to working in this fast-paced and sometimes rapidly changing environment, the ETO Team has developed a finely tuned process to maximize their delivery capabilities. The objective of this paper is to describe the interfaces

Response of ELA-A1 horses immunized with lipopeptide containing an equine infectious anemia virus ELA-A1-restricted CTL epitope to virus challenge.

Science.gov (United States)

Ridgely, Sherritta L; Zhang, Baoshan; McGuire, Travis C

2003-01-17

Lipopeptide containing an ELA-A1-restricted cytotoxic T lymphocyte (CTL) epitope from the envelope surface unit (SU) protein of the EIAV(WSU5) strain was used to immunize three horses having the ELA-A1 haplotype. Peptide-specific ELA-A1-restricted CTL were induced in all three horses, although these were present transiently in PBMC. These horses were further immunized with lipopeptide containing the corresponding CTL epitope from the EIAV(PV) strain. Then, the three immunized horses and three non-immunized horses were challenged by intravenous inoculation with 300 TCID(50) EIAV(PV). All horses developed cell free viremia, fever and thrombocytopenia. However, there was a statistically lower fever and thrombocytopenia severity score in the immunized group. Shorter duration of plasma viral load in two of the three immunized horses likely explains the less severe clinical disease in this group. Results indicate that lipopeptide immunization had a protective effect against development of clinical disease following virus challenge.

Advanced reactor design study. Assessing nonbackfittable concepts for improving uranium utilization in light water reactors

International Nuclear Information System (INIS)

Fleischman, R.M.; Goldsmith, S.; Newman, D.F.; Trapp, T.J.; Spinrad, B.I.

1981-09-01

The objective of the Advanced Reactor Design Study (ARDS) is to identify and evaluate nonbackfittable concepts for improving uranium utilization in light water reactors (LWRs). The results of this study provide a basis for selecting and demonstrating specific nonbackfittable concepts that have good potential for implementation. Lead responsibility for managing the study was assigned to the Pacific Northwest Laboratory (PNL). Nonbackfittable concepts for improving uranium utilization in LWRs on the once-through fuel cycle were selected separately for PWRs and BWRs due to basic differences in the way specific concepts apply to those plants. Nonbackfittable concepts are those that are too costly to incorporate in existing plants, and thus, could only be economically incorporated in new reactor designs or plants in very early stages of construction. Essential results of the Advanced Reactor Design Study are summarized

Systems analysis and futuristic designs of advanced biofuel factory concepts.

Energy Technology Data Exchange (ETDEWEB)

Chianelli, Russ; Leathers, James; Thoma, Steven George; Celina, Mathias C.; Gupta, Vipin P.

2007-10-01

The U.S. is addicted to petroleum--a dependency that periodically shocks the economy, compromises national security, and adversely affects the environment. If liquid fuels remain the main energy source for U.S. transportation for the foreseeable future, the system solution is the production of new liquid fuels that can directly displace diesel and gasoline. This study focuses on advanced concepts for biofuel factory production, describing three design concepts: biopetroleum, biodiesel, and higher alcohols. A general schematic is illustrated for each concept with technical description and analysis for each factory design. Looking beyond current biofuel pursuits by industry, this study explores unconventional feedstocks (e.g., extremophiles), out-of-favor reaction processes (e.g., radiation-induced catalytic cracking), and production of new fuel sources traditionally deemed undesirable (e.g., fusel oils). These concepts lay the foundation and path for future basic science and applied engineering to displace petroleum as a transportation energy source for good.

A Concept Plane using electric distributed propulsion Evaluation of advanced power architecture

OpenAIRE

Ridel , M.; Paluch , B.; Doll , C.; Donjat , D.; Hermetz , J.; Guigon , A.; Schmollgruber , P.; Atinault , O.; Choy , P.; Le Tallec , P.; Dessornes , O.; Lefebvre , T.

2015-01-01

International audience; Starting from electrical distributed propulsion system concept, the ONERA’s engineers demonstrated the viability of an all electrical aircraft for a small business aircraft. This paper describes the advanced power architecture considering energy conversion and power distribution. The design of this advanced power architecture requires the multi-physic integration of different domains as flight performances, safety and environmental requirements (thermal, electric, elec...

Teaching Advanced Concepts in Computer Networks: VNUML-UM Virtualization Tool

Science.gov (United States)

Ruiz-Martinez, A.; Pereniguez-Garcia, F.; Marin-Lopez, R.; Ruiz-Martinez, P. M.; Skarmeta-Gomez, A. F.

2013-01-01

In the teaching of computer networks the main problem that arises is the high price and limited number of network devices the students can work with in the laboratories. Nowadays, with virtualization we can overcome this limitation. In this paper, we present a methodology that allows students to learn advanced computer network concepts through…

Strategi Bisnis pada PT CTL Dengan Pendekatan Metode Tows

Directory of Open Access Journals (Sweden)

Tjia Fie Tjoe

2010-11-01

Full Text Available The purpose of this research is determining direction of the correct business strategy to be applied by PT CTL, a garment company producing cloth for men. Research method used by the author is descriptive analysis with a case study research method. Research is conducted by collecting data obtained through survey by interview and giving questionnaire to all staff and head and also observation by evaluating directly the research object and also through literature study. Data analysis is conducted through input phase by using IFAS and EFAS matrix, adaptation phase with TOWS diagram, TOWS matrix and Internal-External matrix, and also uses SPACE matrix and also BCG matrix to analyse company's finance situation. Based on the conducted analysist the recommended corporation level strategy to be used by the company is diversification strategy direct to growth and stability. 

Advanced Numerical-Algebraic Thinking: Constructing the Concept of Covariation as a Prelude to the Concept of Function

Science.gov (United States)

Hitt, Fernando; Morasse, Christian

2009-01-01

Introduction: In this document we stress the importance of developing in children a structure for advanced numerical-algebraic thinking that can provide an element of control when solving mathematical situations. We analyze pupils' conceptions that induce errors in algebra due to a lack of control in connection with their numerical thinking. We…

[Research advances in secondary development of Chinese patent medicines based on quality by design concept].

Science.gov (United States)

Gong, Xing-Chu; Chen, Teng; Qu, Hai-Bin

2017-03-01

Quality by design (QbD) concept is an advanced pharmaceutical quality control concept. The application of QbD concept in the research and development of pharmaceutical processes of traditional Chinese medicines (TCM) mainly contains five parts, including the definition of critical processes and their evaluation criteria, the determination of critical process parameters and critical material attributes, the establishment of quantitative models, the development of design space, as well as the application and continuous improvement of control strategy. In this work, recent research advances in QbD concept implementation methods in the secondary development of Chinese patent medicines were reviewed, and five promising fields of the implementation of QbD concept were pointed out, including the research and development of TCM new drugs and Chinese medicine granules for formulation, modeling of pharmaceutical processes, development of control strategy based on industrial big data, strengthening the research of process amplification rules, and the development of new pharmaceutical equipment.. Copyright© by the Chinese Pharmaceutical Association.

Advanced Planning Concepts in the Closed-Loop Container Network of ARN

NARCIS (Netherlands)

Le Blanc, H.M.; van Krieken, M.G.C.; Krikke, H.R.; Fleuren, H.A.

2004-01-01

In this paper we discuss a real-life case study in the optimization of the logistics network for the collection of containers from end-of-life vehicle dismantlers in the Netherlands.Advanced planning concepts like dynamic assignment of dismantlers to logistic service providers are analyzed by a

New Developments in the Simulation of Advanced Accelerator Concepts

International Nuclear Information System (INIS)

Paul, K.; Cary, J.R.; Cowan, B.; Bruhwiler, D.L.; Geddes, C.G.R.; Mullowney, P.J.; Messmer, P.; Esarey, E.; Cormier-Michel, E.; Leemans, W.P.; Vay, J.-L.

2008-01-01

Improved computational methods are essential to the diverse and rapidly developing field of advanced accelerator concepts. We present an overview of some computational algorithms for laser-plasma concepts and high-brightness photocathode electron sources. In particular, we discuss algorithms for reduced laser-plasma models that can be orders of magnitude faster than their higher-fidelity counterparts, as well as important on-going efforts to include relevant additional physics that has been previously neglected. As an example of the former, we present 2D laser wakefield accelerator simulations in an optimal Lorentz frame, demonstrating and gt;10 GeV energy gain of externally injected electrons over a 2 m interaction length, showing good agreement with predictions from scaled simulations and theory, with a speedup factor of ∼2,000 as compared to standard particle-in-cell.

Composite Structure Modeling and Analysis of Advanced Aircraft Fuselage Concepts

Science.gov (United States)

Mukhopadhyay, Vivek; Sorokach, Michael R.

2015-01-01

NASA Environmentally Responsible Aviation (ERA) project and the Boeing Company are collabrating to advance the unitized damage arresting composite airframe technology with application to the Hybrid-Wing-Body (HWB) aircraft. The testing of a HWB fuselage section with Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) construction is presently being conducted at NASA Langley. Based on lessons learned from previous HWB structural design studies, improved finite-element models (FEM) of the HWB multi-bay and bulkhead assembly are developed to evaluate the performance of the PRSEUS construction. In order to assess the comparative weight reduction benefits of the PRSEUS technology, conventional cylindrical skin-stringer-frame models of a cylindrical and a double-bubble section fuselage concepts are developed. Stress analysis with design cabin-pressure load and scenario based case studies are conducted for design improvement in each case. Alternate analysis with stitched composite hat-stringers and C-frames are also presented, in addition to the foam-core sandwich frame and pultruded rod-stringer construction. The FEM structural stress, strain and weights are computed and compared for relative weight/strength benefit assessment. The structural analysis and specific weight comparison of these stitched composite advanced aircraft fuselage concepts demonstrated that the pressurized HWB fuselage section assembly can be structurally as efficient as the conventional cylindrical fuselage section with composite stringer-frame and PRSEUS construction, and significantly better than the conventional aluminum construction and the double-bubble section concept.

Introduction of a point mutation into an HLA class I single-chain trimer induces enhancement of CTL priming and antitumor immunity

Directory of Open Access Journals (Sweden)

Masanori Matsui

2014-01-01

Full Text Available We previously discovered one particular HLA-A*02:01 mutant that enhanced peptide-specific cytotoxic T lymphocyte (CTL recognition in vitro compared to wild-type HLA-A*02:01. This mutant contains a single amino acid substitution from histidine to leucine at position 74 (H74L that is located in the peptide-binding groove. To investigate the effect of the H74L mutation on the in vivo CTL priming, we took advantage of the technology of the HLA class I single-chain trimer (SCT in which three components involving a peptide, β2 microglobulin and the HLA class I heavy chain are joined together via flexible linkers. We generated recombinant adenovirus expressing SCT comprised influenza A matrix protein (FMP-derived peptide, β2 microglobulin and the H74L heavy chain. HLA-A*02:01 transgenic mice were immunized with the adenovirus, and the induction of peptide-specific CTLs and antitumor immunity was investigated. It was clearly shown that the H74L mutation enabled the HLA-A*02:01 SCT molecule to dramatically enhance both in vivo priming of FMP-specific CTLs and protection against a lethal challenge of tumor cells expressing FMP. These data present the first evidence that a simple point mutation in the HLA class I heavy chain of SCT is beneficial for improving CTL-based immunotherapy and prophylaxis to control tumors.

Advanced glycation end product (AGE) modified proteins in tears of diabetic patients.

Science.gov (United States)

Zhao, Zhenjun; Liu, Jingfang; Shi, Bingyin; He, Shuixiang; Yao, Xiaoli; Willcox, Mark D P

2010-08-11

High glucose level in diabetic patients may lead to advanced glycation end product (AGE) modified proteins. This study investigated AGE modified proteins in tears and compared their levels in diabetic patients (DM) with non-diabetic controls (CTL). Basal tears were collected from DM with (DR) or without (DNR) retinopathy and CTL. Total AGE modified proteins were detected quantitatively by a dot immunobinding assay. The AGE modified proteins were separated in 1D- and 2D-SDS gels and detected by western-blotting. The individual AGE modified proteins were also compared between groups using densitometry. Compared with the CTL group, tear concentrations of AGE modified proteins were significantly elevated in DR and DNR groups. The concentration of AGE modified proteins in diabetic tears were positively correlated with AGE modified hemoglobin (HbA1c) and postprandial blood glucose level (PBG). Western blotting of AGE modified proteins from 1D-SDS gels showed several bands, the major one at around 60 kDa. The intensities of AGE modified protein bands were higher in DM tears than in CTL tears. Western blotting from 2D-SDS gels showed a strongly stained horizontal strip, which corresponded to the major band in 1D-SDS gels. Most of the other AGE modified protein species were within molecular weight of 30-60 kDa, PI 5.2-7.0. Densitometry analysis demonstrated several AGE modified proteins were elevated in DR or DNR tears. Total and some individual AGE modified proteins were elevated in DM tears. AGE modified proteins in tears may be used as biomarkers to diagnose diabetes and/or diabetic retinopathy.

Proposal for a advanced PWR core with adequate characteristics for passive safety concept

International Nuclear Information System (INIS)

Perrotta, Jose Augusto

1999-01-01

This work presents a discussion upon the suitable from an advanced PWR core, classified by the EPRI as 'Passive PWR' (advanced reactor with passive safety concept to power plants with less than 600 MW electrical power). The discussion upon the type of core is based on nuclear fuel engineering concepts. Discussion is made on type of fuel materials, structural materials, geometric shapes and manufacturing process that are suitable to produce fuel assemblies which give good performance for this type of reactors. The analysis is guided by the EPRI requirements for Advanced Light Water Reactor (ALWR). By means of comparison, the analysis were done to Angra 1 (old type of 600 MWe PWR class), and the design of the Westinghouse Advanced PWR-AP600. It was verified as a conclusion of this work that the modern PWR fuels are suitable for advanced PWR's Nevertheless, this work presents a technical alternative to this kind of fuel, still using UO 2 as fuel, but changing its cylindrical form of pellets and pin type fuel element to plane shape pallets and plate type fuel element. This is not a novelty fuel, since it was used in the 50's at Shippingport Reactor and as an advanced version by CEA of France in the 70's. In this work it is proposed a new mechanical assembly design for this fuel, which can give adequate safety and operational performance to the core of a 'Passive PWR'. (author)

Advanced concepts under development in the United States Breeder-Fuel-Reprocessing Program

International Nuclear Information System (INIS)

Burch, W.D.

1981-01-01

Advanced concepts and techniques for the fuel reprocessing step are being developed. These concepts have been incorporated into the conceptual design of a Hot Experimental Facility (HEF), which is intended to demonstrate reprocessing of the first US breeder demonstration reactor. To achieve system reliability and reduce occupational doses, a concept of totally remote operation and maintenance (termed Remotex) has been conceived and is being developed. In this concept, maintenance and mechanical operations are accomplished with remotely operated bilateral force-reflecting electronic master/slave manipulators. Suitable transport systems, coupled with remote closed-circuit television viewing, are provided to extend man's capabilities into the hostile cell environment. New equipment concepts are being developed for the fuel dismantling and shearing step, a high-temperature dry process termed voloxidation to remove tritium, a continuous rotary dissolver, and for an improved centrifugal solvent contractor. Techniques have been developed, using engineering-scale equipment with active tracers for retention of 85 Kr, radioiodine, 14 C, and 3 H

Human dendritic cells sequentially matured with CD4(+) T cells as a secondary signal favor CTL and long-term T memory cell responses.

Science.gov (United States)

Simon, Thomas; Tanguy-Royer, Séverine; Royer, Pierre-Joseph; Boisgerault, Nicolas; Frikeche, Jihane; Fonteneau, Jean-François; Grégoire, Marc

2012-01-01

Dendritic cells (DCs) are professional antigen-presenting cells involved in the control and initiation of immune responses. In vivo, DCs exposed at the periphery to maturation stimuli migrate to lymph nodes, where they receive secondary signals from CD4+ T helper cells. These DCs become able to initiate CD8+ cytotoxic T lymphocyte (CTL) responses. However, in vitro investigations concerning human monocyte-derived DCs have never focused on their functional properties after such sequential maturation. Here, we studied human DC phenotypes and functions according to this sequential exposure to maturation stimuli. As first signals, we used TNF-α/polyI:C mimicking inflammatory and pathogen stimuli and, as second signals, we compared activated CD4+ T helper cells to a combination of CD40-L/ IFN-γ. Our results show that a sequential activation with activated CD4+ T cells dramatically increased the maturation of DCs in terms of their phenotype and cytokine secretion compared to DCs activated with maturation stimuli delivered simultaneously. Furthermore, this sequential maturation led to the induction of CTL with a long-term effector and central memory phenotypes. Thus, sequential delivery of maturation stimuli, which includes CD4+ T cells, should be considered in the future to improve the induction of long-term CTL memory in DC-based immunotherapy.

Advanced Spacesuit Portable Life Support System Packaging Concept Mock-Up Design & Development

Science.gov (United States)

O''Connell, Mary K.; Slade, Howard G.; Stinson, Richard G.

1998-01-01

A concentrated development effort was begun at NASA Johnson Space Center to create an advanced Portable Life Support System (PLSS) packaging concept. Ease of maintenance, technological flexibility, low weight, and minimal volume are targeted in the design of future micro-gravity and planetary PLSS configurations. Three main design concepts emerged from conceptual design techniques and were carried forth into detailed design, then full scale mock-up creation. "Foam", "Motherboard", and "LEGOtm" packaging design concepts are described in detail. Results of the evaluation process targeted maintenance, robustness, mass properties, and flexibility as key aspects to a new PLSS packaging configuration. The various design tools used to evolve concepts into high fidelity mock ups revealed that no single tool was all encompassing, several combinations were complimentary, the devil is in the details, and, despite efforts, many lessons were learned only after working with hardware.

Advanced fusion concepts program

International Nuclear Information System (INIS)

Dove, W.F.

1978-01-01

While the prospects for the eventual development of a tokamak-based fusion reactor appear promising at the present time, the Department of Energy maintains a vigorous program in alternate magnetic fusion concepts. Several of the concepts presently supported include the toroidal reversed field pinch, Tormac, Elmo Bumpy Torus, and various linear options. Recent technical accomplishments and program evaluations indicate that the possibility now exists for undertaking the next development stage, a proof-of-principle experiment, for a few of the most promising alternate concepts

ELISPOT Assay for Monitoring Cytotoxic T Lymphocytes (CTL Activity in Cancer Vaccine Clinical Trials

Directory of Open Access Journals (Sweden)

Thomas J. Sayers

2012-05-01

Full Text Available The profiling and monitoring of immune responses are key elements in the evaluation of the efficacy and development of new biotherapies, and a number of assays have been introduced for analyzing various immune parameters before, during, and after immunotherapy. The choice of immune assays for a given clinical trial depends on the known or suggested immunomodulating mechanisms associated with the tested therapeutic modality. Cell-mediated cytotoxicity represents a key mechanism in the immune response to various pathogens and tumors. Therefore, the selection of monitoring methods for the appropriate assessment of cell-mediated cytotoxicity is thought to be crucial. Assays that can detect both cytotoxic T lymphocytes (CTL frequency and function, such as the IFN-γ enzyme-linked immunospot assay (ELISPOT have gained increasing popularity for monitoring clinical trials and in basic research. Results from various clinical trials, including peptide and whole tumor cell vaccination and cytokine treatment, have shown the suitability of the IFN-γ ELISPOT assay for monitoring T cell responses. However, the Granzyme B ELISPOT assay and Perforin ELISPOT assay may represent a more direct analysis of cell-mediated cytotoxicity as compared to the IFN-γ ELISPOT, since Granzyme B and perforin are the key mediators of target cell death via the granule-mediated pathway. In this review we analyze our own data and the data reported by others with regard to the application of various modifications of ELISPOT assays for monitoring CTL activity in clinical vaccine trials.

Development of a Luminex Bead Based Assay for Diagnosis of Toxocariasis Using Recombinant Antigens Tc-CTL-1 and Tc-TES-26.

Directory of Open Access Journals (Sweden)

John P Anderson

Full Text Available The clinical spectrum of human disease caused by the roundworms Toxocara canis and Toxocara cati ranges from visceral and ocular larva migrans to covert toxocariasis. The parasite is not typically recovered in affected tissues, so detection of parasite-specific antibodies is usually necessary for establishing a diagnosis. The most reliable immunodiagnostic methods use the Toxocara excretory-secretory antigens (TES-Ag in ELISA formats to detect Toxocara-specific antibodies. To eliminate the need for native parasite materials, we identified and purified immunodiagnostic antigens using 2D gel electrophoresis followed by electrospray ionization mass spectrometry. Three predominant immunoreactive proteins were found in the TES; all three had been previously described in the literature: Tc-CTL-1, Tc-TES-26, and Tc-MUC-3. We generated Escherichia coli expressed recombinant proteins for evaluation in Luminex based immunoassays. We were unable to produce a functional assay with the Tc-MUC-3 recombinant protein. Tc-CTL-1 and Tc-TES-26 were successfully coupled and tested using defined serum batteries. The use of both proteins together generated better results than if the proteins were used individually. The sensitivity and specificity of the assay for detecting visceral larval migrans using Tc-CTL-1 plus Tc-TES-26 was 99% and 94%, respectively; the sensitivity for detecting ocular larval migrans was 64%. The combined performance of the new assay was superior to the currently available EIA and could potentially be employed to replace current assays that rely on native TES-Ag.

Transgene IL-6 Enhances DC-Stimulated CTL Responses by Counteracting CD4+25+Foxp3+ Regulatory T Cell Suppression via IL-6-Induced Foxp3 Downregulation

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Kalpana Kalyanasundaram Bhanumathy

2014-03-01

Full Text Available Dendritic cells (DCs, the most potent antigen-presenting cells have been extensively applied in clinical trials for evaluation of antitumor immunity. However, the efficacy of DC-mediated cancer vaccines is still limited as they are unable to sufficiently break the immune tolerance. In this study, we constructed a recombinant adenoviral vector (AdVIL-6 expressing IL-6, and generated IL-6 transgene-engineered DC vaccine (DCOVA/IL-6 by transfection of murine bone marrow-derived ovalbumin (OVA-pulsed DCs (DCOVA with AdVIL-6. We then assessed DCOVA/IL-6-stimulated cytotoxic T-lymphocyte (CTL responses and antitumor immunity in OVA-specific animal tumor model. We demonstrate that DCOVA/IL-6 vaccine up-regulates expression of DC maturation markers, secretes transgene-encoded IL-6, and more efficiently stimulates OVA-specific CTL responses and therapeutic immunity against OVA-expressing B16 melanoma BL6-10OVA in vivo than the control DCOVA/Null vaccine. Moreover, DCOVA/IL-6-stimulated CTL responses were relatively maintained in mice with transfer of CD4+25+Foxp3+ Tr-cells, but significantly reduced when treated with anti-IL-6 antibody. In addition, we demonstrate that IL-6 down-regulates Foxp3-expression of CD4+25+Foxp3+ Tr-cells in vitro. Taken together, our results demonstrate that AdV-mediated IL-6 transgene-engineered DC vaccine stimulates potent CTL responses and antitumor immunity by counteracting CD4+25+ Tr immunosuppression via IL-6-induced Foxp3 down-regulation. Thus, IL-6 may be a good candidate for engineering DCs for cancer immunotherapy.

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

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Aurélie Durgeau

2018-01-01

Full Text Available Recent advances in cancer treatment have emerged from new immunotherapies targeting T-cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA-4 and programmed cell death (PD-1. In this context, anti-CTLA-4 and anti-PD-1 monoclonal antibodies have demonstrated survival benefits in numerous cancers, including melanoma and non-small-cell lung carcinoma. PD-1-expressing CD8+ T lymphocytes appear to play a major role in the response to these immune checkpoint inhibitors (ICI. Cytotoxic T lymphocytes (CTL eliminate malignant cells through recognition by the T-cell receptor (TCR of specific antigenic peptides presented on the surface of cancer cells by major histocompatibility complex class I/beta-2-microglobulin complexes, and through killing of target cells, mainly by releasing the content of secretory lysosomes containing perforin and granzyme B. T-cell adhesion molecules and, in particular, lymphocyte-function-associated antigen-1 and CD103 integrins, and their cognate ligands, respectively, intercellular adhesion molecule 1 and E-cadherin, on target cells, are involved in strengthening the interaction between CTL and tumor cells. Tumor-specific CTL have been isolated from tumor-infiltrating lymphocytes and peripheral blood lymphocytes (PBL of patients with varied cancers. TCRβ-chain gene usage indicated that CTL identified in vitro selectively expanded in vivo at the tumor site compared to autologous PBL. Moreover, functional studies indicated that these CTL mediate human leukocyte antigen class I-restricted cytotoxic activity toward autologous tumor cells. Several of them recognize truly tumor-specific antigens encoded by mutated genes, also known as neoantigens, which likely play a key role in antitumor CD8 T-cell immunity. Accordingly, it has been shown that the presence of T lymphocytes directed toward tumor neoantigens is associated with patient response to immunotherapies, including ICI, adoptive cell transfer

Summary Report of Working Group 7: Muon Colliders and Advanced Concepts

Energy Technology Data Exchange (ETDEWEB)

Nagaitsev, Sergei [Fermilab; Berg, J.Scott [Brookhaven

2012-07-01

The primary subject of working group 7 at the 2012 Advanced Accelerator Concepts Workshop was muon accelerators for a muon collider or neutrino factory. Additionally, this working group included topics that did not fit well into other working groups. Two subjects were discussed by more than one speaker: lattices to create a perfectly integrable nonlinear lattice, and a Penning trap to create antihydrogen.

Preliminary design concepts for the advanced neutron source reactor systems

International Nuclear Information System (INIS)

Peretz, F.J.

1988-01-01

This paper describes the initial design work to develop the reactor systems hardware concepts for the advanced neutron source (ANS) reactor. This project has not yet entered the conceptual design phase; thus, design efforts are quite preliminary. This paper presents the collective work of members of the Oak Ridge National Laboratory, Martin Marietta Energy Systems, Inc., Engineering Division, and other participating organizations. The primary purpose of this effort is to show that the ANS reactor concept is realistic from a hardware standpoint and to show that project objectives can be met. It also serves to generate physical models for use in neutronic and thermal-hydraulic core design efforts and defines the constraints and objectives for the design. Finally, this effort will develop the criteria for use in the conceptual design of the reactor

Proceedings of the Workshop on Advanced Network and Technology Concepts for Mobile, Micro, and Personal Communications

Science.gov (United States)

Paul, Lori (Editor)

1991-01-01

The Workshop on Advanced Network and Technology Concepts for Mobile, Micro, and Personal Communications was held at NASA's JPL Laboratory on 30-31 May 1991. It provided a forum for reviewing the development of advanced network and technology concepts for turn-of-the-century telecommunications. The workshop was organized into three main categories: (1) Satellite-Based Networks (L-band, C-band, Ku-band, and Ka-band); (2) Terrestrial-Based Networks (cellular, CT2, PCN, GSM, and other networks); and (3) Hybrid Satellite/Terrestrial Networks. The proceedings contain presentation papers from each of the above categories.

The Effect of Contextual Teaching and Learning Combined with Peer Tutoring towards Learning Achievement on Human Digestive System Concept

Directory of Open Access Journals (Sweden)

Farhah Abadiyah

2017-11-01

Full Text Available This research aims to know the influence of contextual teaching and learning (CTL combined with peer tutoring toward learning achievement on human digestive system concept. This research was conducted at one of State Senior High School in South Tangerang in the academic year of 2016/2017. The research method was quasi experiment with nonequivalent pretest-postest control group design. The sample was taken by simple random sampling. The total of the sampels were 86 students which consisted of 44 students as a controlled group and 42 students as an experimental group. The research instrument was objective test which consisted of 25 multiple choice items of each pretest and posttest. The research also used observation sheets for teacher and students activity. The result of data analysis using t-test on the two groups show that the value of tcount was 2.40 and ttable was 1.99 on significant level α = 0,05, so that tcount > ttable.. This result indicated that there was influence of contextual teaching and learning (CTL combined with peer tutoring toward learning achievement on human digestive system concept.

Advanced direct liquefaction concepts for PETC generic units. Final report, Phase I

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-03-01

The Advanced Concepts for Direct Coal Liquefaction program was initiated by the Department of Energy in 1991 to develop technologies that could significantly reduce the cost of producing liquid fuels by the direct liquefaction of coal. The advanced 2-stage liquefaction technology that was developed at Wilsonville over the past 10 years has contributed significantly toward decreasing the cost of producing liquids from coal to about $33/bbl. It remains, however, the objective of DOE to further reduce this cost to a level more competitive with petroleum based products. This project, among others, was initiated to investigate various alternative approaches to develop technologies that might ultimately lead to a 25 % reduction in cost of product. In this project a number of novel concepts were investigated, either individually or in a coupled configuration that had the potential to contribute toward meeting the DOE goal. The concepts included mature technologies or ones closely related to them, such as coal cleaning by oil agglomeration, fluid coking and distillate hydrotreating and dewaxing. Other approaches that were either embryonic or less developed were chemical pretreatment of coal to remove oxygen, and dispersed catalyst development for application in the 2-stage liquefaction process. This report presents the results of this project. It is arranged in four sections which were prepared by participating organizations responsible for that phase of the project. A summary of the overall project and the principal results are given in this section. First, however, an overview of the process economics and the process concepts that were developed during the course of this program is presented.

ULTRA SCWR+: Practical advanced water reactor concepts

International Nuclear Information System (INIS)

Duffey, Romney; Khartabil, Hussam; Kuran, Sermet; Zhou, Tracy; Pioro, Igor

2008-01-01

Modern thermal power plants now utilize supercritical steam cycles with thermal efficiencies of over 45%. Recent developments have lead to Ultra-SuperCritical (USC) systems, which adopt reheat turbines that can attain efficiencies of over 50%. Because these turbines are already developed, demonstrated and deployed worldwide, and use existing and traditional steam cycle technology, the simplest nuclear advance is to utilize these proven thermal cycle conditions by coupling this turbine type to a reactor. This development direction is fundamentally counter to the usual approach of adopting high-temperature gas-cooled (helium-cooled) reactor cycles, for which turbines have yet to be demonstrated on commercial scale unlike the supercritical steam turbines. The ULTRA (Ultra-supercritical Light water Thermal ReActor) SCWR+ concept adopts the fundamental design approach of matching a water and steam-cooled reactor to the ultra-supercritical steam cycle, adopting the existing and planned thermal power plant turbines. The HP and IP sections are fed with conditions of 25 MPa/625degC and 7 MPa/700degC, respectively, to achieve operating plant thermal efficiencies in excess of 50%, with a direct turbine cycle. By using such low-pressure reheated steam, this concept also adopts technology that was explored and used many years ago in existing water reactors, with the potential to produce large quantities of low cost heat, which can be used for other industrial and district processes. Pressure-Tube (PT) reactors are suitable for adoption of this design approach and, in addition, have other advantages that will significantly improve water-cooled reactor technology. These additional advantages include enhanced safety and improved resource utilization and proliferation resistance. This paper describes the PT-SCWR+ concept and its potential enhancements. (author)

Human dendritic cells sequentially matured with CD4+ T cells as a secondary signal favor CTL and long-term T memory cell responses

Directory of Open Access Journals (Sweden)

Thomas Simon

2012-01-01

Full Text Available Dendritic cells (DCs are professional antigen-presenting cells involved in the control and initiation of immune responses. In vivo, DCs exposed at the periphery to maturation stimuli migrate to lymph nodes, where they receive secondary signals from CD4+ T helper cells. These DCs become able to initiate CD8+ cytotoxic T lymphocyte (CTL responses. However, in vitro investigations concerning human monocyte-derived DCs have never focused on their functional properties after such sequential maturation. Here, we studied human DC phenotypes and functions according to this sequential exposure to maturation stimuli. As first signals, we used TNF-α/polyI:C mimicking inflammatory and pathogen stimuli and, as second signals, we compared activated CD4+ T helper cells to a combination of CD40-L/ IFN-γ. Our results show that a sequential activation with activated CD4+ T cells dramatically increased the maturation of DCs in terms of their phenotype and cytokine secretion compared to DCs activated with maturation stimuli delivered simultaneously. Furthermore, this sequential maturation led to the induction of CTL with a long-term effector and central memory phenotypes. Thus, sequential delivery of maturation stimuli, which includes CD4+ T cells, should be considered in the future to improve the induction of long-term CTL memory in DC-based immunotherapy.

Effects of Advance Organizer Instruction on Preschool Children's Learning of Musical Concepts.

Science.gov (United States)

Lawton, Joseph T.; Johnson, Ann

1992-01-01

Presents results of a study of the effects of advance organizer instruction on preschool children's learning of the musical concepts of dynamics, pitch, tempo, and rhythm. Reports that three modes and three methods of presentation were evaluated. Concludes that, although results did vary with mode, the method of presentation had no significant…

Concepts for a slow-positron target at the advanced photon source

International Nuclear Information System (INIS)

Lessner, E.; White, M.

1997-01-01

The Advanced Photon Source (APS) linear accelerator beam could be used to produce slow positrons during the hours between the storage ring injection cycles. Initial concepts for the design of a target that is optimized for slow-positron production are discussed, and simulation results are presented. Some possible ways to increase the nominal linac beam power for improved slow-positron production are also discussed

Prestressed-concrete pressure vessels and their applicability to advanced-energy-system concepts

International Nuclear Information System (INIS)

Naus, D.J.

1983-01-01

Prestressed concrete pressure vessels (PCPVs) are, in essence, spaced steel structures since their strength is derived from a multitude of steel elements made up of deformed reinforcing bars and prestressing tendons which are present in sufficient quantities to carry tension loads imposed on the vessel. Other major components of a PCPV include the concrete, liner and cooling system, and insulation. PCPVs exhibit a number of advantages which make them ideally suited for application to advanced energy concepts: fabricability in virtually any size and shape using available technology, improved safety, reduced capital costs, and a history of proven performance. PCPVs have many applications to both nuclear- and non-nuclear-based energy systems concepts. Several of these concepts will be discussed as well as the research and development activities conducted at ORNL in support of PCPV development

Development of Advanced Concept for Shortening Construction Period of ABWR Plant

International Nuclear Information System (INIS)

Hiroshi Ijichi; Toshio Yamashita; Masahiro Tsutagawa; Hiroya Mori; Nobuaki Ooshima; Jun Miura; Minoru Kanechika; Nobuaki Miura

2002-01-01

Construction of a nuclear power plant (NPP) requires a very long period because of large amount of construction materials and many issues for negotiation among multiple sections. Shortening the construction period advances the date of return on an investment, and can also result in reduced construction cost. Therefore, the study of this subject has a very high priority for utilities. We achieved a construction period of 37 months from the first concrete work to fuel loading (F/L) (51.5 months from the inspection of the foundation (I/F) to the start of commercial operation (C/O)) at the Kashiwazaki-Kariwa NPPs No. 6 and 7 (KK-6/7), which are the first ABWR plants in the world. At TEPCO's next plant, we think that a construction period of less than 36 months (45 months from I/F to C/O) can be realized based on conventional methods such as early start of equipment installation and blocking of equipment to be brought in advance. Furthermore, we are studying the feasibility of a 21.5-month construction period (30 months from I/F to C/O) with advanced ideas and methods. The important concepts for a 21.5-month construction period are adoption of a new building structure that is the steel plate reinforced concrete (SC) structure and promotion of extensive modularization of equipment and building structure. With introducing these new concepts, we are planning the master schedule (M/S) and finding solutions to conflicts in the schedule of area release from building construction work to equipment installation work (schedule-conflicts.) In this report, we present the shortest construction period and an effective method to put it into practice for the conventional general arrangement (GA) of ABWR. In the future, we will continue the study on the improvement of building configuration and arrangements, and make clear of the concept for large composite modules of building structures and equipment. (authors)

DEVELOPMENT OF OPERATIONAL CONCEPTS FOR ADVANCED SMRs: THE ROLE OF COGNITIVE SYSTEMS ENGINEERING

Energy Technology Data Exchange (ETDEWEB)

Jacques Hugo; David Gertman

2014-04-01

Advanced small modular reactors (AdvSMRs) will use advanced digital instrumentation and control systems, and make greater use of automation. These advances not only pose technical and operational challenges, but will inevitably have an effect on the operating and maintenance (O&M) cost of new plants. However, there is much uncertainty about the impact of AdvSMR designs on operational and human factors considerations, such as workload, situation awareness, human reliability, staffing levels, and the appropriate allocation of functions between the crew and various automated plant systems. Existing human factors and systems engineering design standards and methodologies are not current in terms of human interaction requirements for dynamic automated systems and are no longer suitable for the analysis of evolving operational concepts. New models and guidance for operational concepts for complex socio-technical systems need to adopt a state-of-the-art approach such as Cognitive Systems Engineering (CSE) that gives due consideration to the role of personnel. This approach we report on helps to identify and evaluate human challenges related to non-traditional concepts of operations. A framework - defining operational strategies was developed based on the operational analysis of Argonne National Laboratory’s Experimental Breeder Reactor-II (EBR-II), a small (20MWe) sodium-cooled reactor that was successfully operated for thirty years. Insights from the application of the systematic application of the methodology and its utility are reviewed and arguments for the formal adoption of CSE as a value-added part of the Systems Engineering process are presented.

Human Research Program Advanced Exercise Concepts (AEC) Overview

Science.gov (United States)

Perusek, Gail; Lewandowski, Beth; Nall, Marsha; Norsk, Peter; Linnehan, Rick; Baumann, David

2015-01-01

Exercise countermeasures provide benefits that are crucial for successful human spaceflight, to mitigate the spaceflight physiological deconditioning which occurs during exposure to microgravity. The NASA Human Research Program (HRP) within the Human Exploration and Operations Mission Directorate (HEOMD) is managing next generation Advanced Exercise Concepts (AEC) requirements development and candidate technology maturation to Technology Readiness Level (TRL) 7 (ground prototyping and flight demonstration) for all exploration mission profiles from Multi Purpose Crew Vehicle (MPCV) Exploration Missions (up to 21 day duration) to Mars Transit (up to 1000 day duration) missions. These validated and optimized exercise countermeasures systems will be provided to the ISS Program and MPCV Program for subsequent flight development and operations. The International Space Station (ISS) currently has three major pieces of operational exercise countermeasures hardware: the Advanced Resistive Exercise Device (ARED), the second-generation (T2) treadmill, and the cycle ergometer with vibration isolation system (CEVIS). This suite of exercise countermeasures hardware serves as a benchmark and is a vast improvement over previous generations of countermeasures hardware, providing both aerobic and resistive exercise for the crew. However, vehicle and resource constraints for future exploration missions beyond low Earth orbit will require that the exercise countermeasures hardware mass, volume, and power be minimized, while preserving the current ISS capabilities or even enhancing these exercise capabilities directed at mission specific physiological functional performance and medical standards requirements. Further, mission-specific considerations such as preservation of sensorimotor function, autonomous and adaptable operation, integration with medical data systems, rehabilitation, and in-flight monitoring and feedback are being developed for integration with the exercise

Advanced direct liquefaction concepts for PETC generic units

Energy Technology Data Exchange (ETDEWEB)

1992-04-01

In the Advance Coal Liquefaction Concept Proposal (ACLCP) carbon monoxide (CO) and water have been proposed as the primary reagents in the pretreatment process. The main objective of this project is to develop a methodology for pretreating coal under mild conditions based on a combination of existing processes which have shown great promise in liquefaction, extraction and pyrolysis studies. The aim of this pretreatment process is to partially depolymerise the coal, eliminate oxygen and diminish the propensity for retograde reactions during subsequent liquefaction. The desirable outcome of the CO pretreatment step should be: (1) enhanced liquefaction activity and/or selectivity toward products of higher quality due to chemical modification of the coal structure; (2) cleaner downstream products; (3) overall improvement in operability and process economics.

Advanced Supersonic Nozzle Concepts: Experimental Flow Visualization Results Paired With LES

Science.gov (United States)

Berry, Matthew; Magstadt, Andrew; Stack, Cory; Gaitonde, Datta; Glauser, Mark; Syracuse University Team; The Ohio State University Team

2015-11-01

Advanced supersonic nozzle concepts are currently under investigation, utilizing multiple bypass streams and airframe integration to bolster performance and efficiency. This work focuses on the parametric study of a supersonic, multi-stream jet with aft deck. The single plane of symmetry, rectangular nozzle, displays very complex and unique flow characteristics. Flow visualization techniques in the form of PIV and schlieren capture flow features at various deck lengths and Mach numbers. LES is compared to the experimental results to both validate the computational model and identify limitations of the simulation. By comparing experimental results to LES, this study will help create a foundation of knowledge for advanced nozzle designs in future aircraft. SBIR Phase II with Spectral Energies, LLC under direction of Barry Kiel.

Advanced High and Low Fidelity HPC Simulations of FCS Concept Designs for Dynamic Systems

National Research Council Canada - National Science Library

Sandhu, S. S; Kanapady, R; Tamma, K. K

2004-01-01

...) resources of many Army initiatives. In this paper we present a new and advanced HPC based rigid and flexible modeling and simulation technology capable of adaptive high/low fidelity modeling that is useful in the initial design concept...

Waste-to-energy advanced cycles and new design concepts for efficient power plants

CERN Document Server

Branchini, Lisa

2015-01-01

This book provides an overview of state-of-the-art technologies for energy conversion from waste, as well as a much-needed guide to new and advanced strategies to increase Waste-to-Energy (WTE) plant efficiency. Beginning with an overview of municipal solid waste production and disposal, basic concepts related to Waste-To-Energy conversion processes are described, highlighting the most relevant aspects impacting the thermodynamic efficiency of WTE power plants. The pervasive influences of main steam cycle parameters and plant configurations on WTE efficiency are detailed and quantified. Advanc

Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

Directory of Open Access Journals (Sweden)

Xihui "Paul" Zhang

2015-06-01

Full Text Available Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We present a classic brain teaser that is used to communicate and demonstrate advanced software development concepts and techniques. Our results show that students with varied academic experiences and goals, assuming at least one procedural/structured programming pre-requisite, can benefit from and also be challenged by such an exercise. Although this problem has been used by others in the classroom, we believe that our use of this problem in imparting such a broad range of topics to a diverse student population is unique.

Advanced automation concepts applied to Experimental Breeder Reactor-II startup

International Nuclear Information System (INIS)

Berkan, R.C.; Upadhyaya, B.R.; Bywater, R.L.

1991-08-01

The major objective of this work is to demonstrate through simulations that advanced liquid-metal reactor plants can be operated from low power by computer control. Development of an automatic control system with this objective will help resolve specific issues and provide proof through demonstration that automatic control for plant startup is feasible. This paper presents an advanced control system design for startup of the Experimental Breeder Reactor-2 (EBR-2) located at Idaho Falls, Idaho. The design incorporates recent methods in nonlinear control with advanced diagnostics techniques such as neural networks to form an integrated architecture. The preliminary evaluations are obtained in a simulated environment by a low-order, valid nonlinear model. Within the framework of phase 1 research, the design includes an inverse dynamics controller, a fuzzy controller, and an artificial neural network controller. These three nonlinear control modules are designed to follow the EBR-2 startup trajectories in a multi-input/output regime. They are coordinated by a supervisory routine to yield a fault-tolerant, parallel operation. The control system operates in three modes: manual, semiautomatic, and fully automatic control. The simulation results of the EBR-2 startup transients proved the effectiveness of the advanced concepts. The work presented in this paper is a preliminary feasibility analysis and does not constitute a final design of an automated startup control system for EBR-2. 14 refs., 43 figs

Conceptual study of advanced PWR systems. A study of passive and inherent safety design concepts for advanced light water reactors

Energy Technology Data Exchange (ETDEWEB)

Chang, Soon Heung; No, Hee Cheon; Baek, Won Pil; Jae, Shim Young; Lee, Goung Jin; Na, Man Gyun; Lee, Jae Young; Kim, Han Gon; Kang, Ki Sig; Moon, Sang Ki; Kim, Yun Il; Park, Jae Wook; Yang, Soo Hyung; Kim, Soo Hyung; Lee, Seong Wook; Kim, Hong Che; Park, Hyun Sik; Jeong, Ji Hwan; Lee, Sang Il; Jung, Hae Yong; Kim, Hyong Tae; Chae, Kyung Sun; Moon, Ki Hoon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1995-08-01

The five thermal-hydraulic concepts chosen for advanced PWR have been studied as follows: (1) Critical Heat Flux: Review of previous works, analysis of parametric trends, analysis of transient CHF characteristics, extension of the CHF date bank, survey and assessment of correlations, design of a intermediate-pressure CHF test loop have been performed. (2) Passive Cooling Concepts for Concrete Containment system: Review of condensation phenomena with noncondensable gases, selection of a promising concept (i.e., use of external condensers), design of test loop according to scaling laws have been accomplished. and computer programs based on the control-volume approach, and the conceptual design of test loop have been accomplished. (4) Fluidic Diode Concepts: Review of previous applications of the concept, analysis major parameters affecting the performance, development of a computational code, and conceptual investigation of the verification test loop have been performed. (5) Wet Thermal Insulator: Review of previous works, selection of promising methods ( i.e. ceramic fiber in a steel case and mirror-type insulator), and conceptual design of the experimental loop have been performed. (author). 9 refs.

CATHENA Analysis Of Candu Advanced Passive Moderator Concept In Normal Operation Condition

International Nuclear Information System (INIS)

Alfa, Sudjatmi K

2001-01-01

In the CANDU - advanced passive moderator (APM) concept, the positive void reactivity is eliminated by reducing the density of the moderator. The simple model for the CANDU APM concept consists of the calandria, heat exchanger, pump, and a stabilizing tank, along with connecting piping. The calandria is divided into two parts, one part simulates the down area, while the other simulates up flow area. To demonstrate the thermalhydraulic behavior of the APM concept, Canadian algorithm for thermalhydraulic network analysis (CATHENA) code is used. The simulation for a pressure boundary condition of 300, 330 and 360 kPa and for water coolant mass flow rate boundary conditions of 2000 and 3000 kg/s respectively have been studied. Preliminary results show that there is boiling in the core, with vapor condensing in the heat exchanger. It is important to note, that the solution had not reached steady state when the boiling occurred

Advanced Hybrid Spacesuit Concept Featuring Integrated Open Loop and Closed Loop Ventilation Systems

Science.gov (United States)

Daniel, Brian A.; Fitzpatrick, Garret R.; Gohmert, Dustin M.; Ybarra, Rick M.; Dub, Mark O.

2013-01-01

A document discusses the design and prototype of an advanced spacesuit concept that integrates the capability to function seamlessly with multiple ventilation system approaches. Traditionally, spacesuits are designed to operate both dependently and independently of a host vehicle environment control and life support system (ECLSS). Spacesuits that operate independent of vehicle-provided ECLSS services must do so with equipment selfcontained within or on the spacesuit. Suits that are dependent on vehicle-provided consumables must remain physically connected to and integrated with the vehicle to operate properly. This innovation is the design and prototype of a hybrid spacesuit approach that configures the spacesuit to seamlessly interface and integrate with either type of vehicular systems, while still maintaining the ability to function completely independent of the vehicle. An existing Advanced Crew Escape Suit (ACES) was utilized as the platform from which to develop the innovation. The ACES was retrofitted with selected components and one-off items to achieve the objective. The ventilation system concept was developed and prototyped/retrofitted to an existing ACES. Components were selected to provide suit connectors, hoses/umbilicals, internal breathing system ducting/ conduits, etc. The concept utilizes a lowpressure- drop, high-flow ventilation system that serves as a conduit from the vehicle supply into the suit, up through a neck seal, into the breathing helmet cavity, back down through the neck seal, out of the suit, and returned to the vehicle. The concept also utilizes a modified demand-based breathing system configured to function seamlessly with the low-pressure-drop closed-loop ventilation system.

Technology and applications of advanced accelerator concepts

CERN Document Server

Chou, Weiren

2016-01-01

Since its invention in the 1920s, particle accelerators have made tremendous progress in accelerator science, technology and applications. However, the fundamental acceleration principle, namely, to apply an external radiofrequency (RF) electric field to accelerate charged particles, remains unchanged. As this method (either room temperature RF or superconducting RF) is approaching its intrinsic limitation in acceleration gradient (measured in MeV/m), it becomes apparent that new methods with much higher acceleration gradient (measured in GeV/m) must be found for future very high energy accelerators as well as future compact (table-top or room-size) accelerators. This volume introduces a number of advanced accelerator concepts (AAC) — their principles, technologies and potential applications. For the time being, none of them stands out as a definitive direction in which to go. But these novel ideas are in hot pursuit and look promising. Furthermore, some AAC requires a high power laser system. This has the ...

Dynamics of a viral infection model with delayed CTL response and immune circadian rhythm

International Nuclear Information System (INIS)

Bai Zhenguo; Zhou Yicang

2012-01-01

This paper studies the global dynamics of a viral infection model that takes into account circadian rhythm and time delay in the CTL response. It is shown that the basic reproduction numbers, R 0 and R 1 , determine the outcome of viral infection. Numerical simulations demonstrate that the changes in the amplitude of lytic component can generate a variety of dynamical patterns, ranging from simple daily oscillation to multi-day dynamics and eventually chaos, whereas time delay can alter the period of oscillation for the larger level of periodic forcing. These results can help to explain the viral oscillation behaviors, which were observed in chronic HBV and HCV infection patients.

The Effects of Advance Organizers and Within-Text Questions on the Learning of a Taxonomy of Concepts. Technical Report No. 357.

Science.gov (United States)

Bernard, Michael E.

This study, presented in three parts, investigated the effects of a group of single-concept instructional variables on the learning at an advanced level of attainment of taxonomy of behavior management concepts. The effects of presenting advance organizers and inserting within-text questions was also examined. The influence of the single-concept…

Advanced Welding Concepts

Science.gov (United States)

Ding, Robert J.

2010-01-01

Four advanced welding techniques and their use in NASA are briefly reviewed in this poster presentation. The welding techniques reviewed are: Solid State Welding, Friction Stir Welding (FSW), Thermal Stir Welding (TSW) and Ultrasonic Stir Welding.

Fostering clinical reasoning in physiotherapy: comparing the effects of concept map study and concept map completion after example study in novice and advanced learners.

Science.gov (United States)

Montpetit-Tourangeau, Katherine; Dyer, Joseph-Omer; Hudon, Anne; Windsor, Monica; Charlin, Bernard; Mamede, Sílvia; van Gog, Tamara

2017-12-01

Health profession learners can foster clinical reasoning by studying worked examples presenting fully worked out solutions to a clinical problem. It is possible to improve the learning effect of these worked examples by combining them with other learning activities based on concept maps. This study investigated which combinaison of activities, worked examples study with concept map completion or worked examples study with concept map study, fosters more meaningful learning of intervention knowledge in physiotherapy students. Moreover, this study compared the learning effects of these learning activity combinations between novice and advanced learners. Sixty-one second-year physiotherapy students participated in the study which included a pre-test phase, a 130-min guided-learning phase and a four-week self-study phase. During the guided and self-study learning sessions, participants had to study three written worked examples presenting the clinical reasoning for selecting electrotherapeutic currents to treat patients with motor deficits. After each example, participants engaged in either concept map completion or concept map study depending on which learning condition they were randomly allocated to. Students participated in an immediate post-test at the end of the guided-learning phase and a delayed post-test at the end of the self-study phase. Post-tests assessed the understanding of principles governing the domain of knowledge to be learned (conceptual knowledge) and the ability to solve new problems that have similar (i.e., near transfer) or different (i.e., far transfer) solution rationales as problems previously studied in the examples. Learners engaged in concept map completion outperformed those engaged in concept map study on near transfer (p = .010) and far transfer (p concept map completion led to greater transfer performance than worked examples study combined with concept map study for both novice and advanced learners. Concept map completion

Kinetics of HIV-1 CTL epitopes recognized by HLA I alleles in HIV-infected individuals at times near primary infection: the Provir/Latitude45 study.

Directory of Open Access Journals (Sweden)

Jennifer Papuchon

Full Text Available In patients responding successfully to ART, the next therapeutic step is viral cure. An interesting strategy is antiviral vaccination, particularly involving CD8 T cell epitopes. However, attempts at vaccination are dependent on the immunogenetic background of individuals. The Provir/Latitude 45 project aims to investigate which CTL epitopes in proviral HIV-1 will be recognized by the immune system when HLA alleles are taken into consideration. A prior study (Papuchon et al, PLoS ONE 2013 showed that chronically-infected patients under successful ART exhibited variations of proviral CTL epitopes compared to a reference viral strain (HXB2 and that a generic vaccine may not be efficient. Here, we investigated viral and/or proviral CTL epitopes at different time points in recently infected individuals of the Canadian primary HIV infection cohort and assessed the affinity of these epitopes for HLA alleles during the study period. An analysis of the results confirms that it is not possible to fully predict which epitopes will be recognized by the HLA alleles of the patients if the reference sequences and epitopes are taken as the basis of simulation. Epitopes may be seen to vary in circulating RNA and proviral DNA. Despite this confirmation, the overall variability of the epitopes was low in these patients who are temporally close to primary infection.

Kinetics of HIV-1 CTL epitopes recognized by HLA I alleles in HIV-infected individuals at times near primary infection: the Provir/Latitude45 study.

Science.gov (United States)

Papuchon, Jennifer; Pinson, Patricia; Guidicelli, Gwenda-Line; Bellecave, Pantxika; Thomas, Réjean; LeBlanc, Roger; Reigadas, Sandrine; Taupin, Jean-Luc; Baril, Jean Guy; Routy, Jean Pierre; Wainberg, Mark; Fleury, Hervé

2014-01-01

In patients responding successfully to ART, the next therapeutic step is viral cure. An interesting strategy is antiviral vaccination, particularly involving CD8 T cell epitopes. However, attempts at vaccination are dependent on the immunogenetic background of individuals. The Provir/Latitude 45 project aims to investigate which CTL epitopes in proviral HIV-1 will be recognized by the immune system when HLA alleles are taken into consideration. A prior study (Papuchon et al, PLoS ONE 2013) showed that chronically-infected patients under successful ART exhibited variations of proviral CTL epitopes compared to a reference viral strain (HXB2) and that a generic vaccine may not be efficient. Here, we investigated viral and/or proviral CTL epitopes at different time points in recently infected individuals of the Canadian primary HIV infection cohort and assessed the affinity of these epitopes for HLA alleles during the study period. An analysis of the results confirms that it is not possible to fully predict which epitopes will be recognized by the HLA alleles of the patients if the reference sequences and epitopes are taken as the basis of simulation. Epitopes may be seen to vary in circulating RNA and proviral DNA. Despite this confirmation, the overall variability of the epitopes was low in these patients who are temporally close to primary infection.

Novel CTL epitopes identified through a Y. pestis proteome-wide analysis in the search for vaccine candidates against plague.

Science.gov (United States)

Zvi, Anat; Rotem, Shahar; Zauberman, Ayelet; Elia, Uri; Aftalion, Moshe; Bar-Haim, Erez; Mamroud, Emanuelle; Cohen, Ofer

2017-10-20

The causative agent of Plague, Yersinia pestis, is a highly virulent pathogen and a potential bioweapon. Depending on the route of infection, two prevalent occurrences of the disease are known, bubonic and pneumonic. The latter has a high fatality rate. In the absence of a licensed vaccine, intense efforts to develop a safe and efficacious vaccine have been conducted, and humoral-driven subunit vaccines containing the F1 and LcrV antigens are currently under clinical trials. It is well known that a cellular immune response might have an essential additive value to immunity and protection against Y. pestis infection. Nevertheless, very few documented epitopes eliciting a protective T-cell response have been reported. Here, we present a combined high throughput computational and experimental effort towards identification of CD8 T-cell epitopes. All 4067 proteins of Y. pestis were analyzed with state-of-the-art recently developed prediction algorithms aimed at mapping potential MHC class I binders. A compilation of the results obtained from several prediction methods revealed a total of 238,000 peptide candidates, which necessitated downstream filtering criteria. Our previously established and proven approach for enrichment of true positive CTL epitopes, which relies on mapping clusters rich in tandem or overlapping predicted MHC binders ("hotspots"), was applied, as well as considerations of predicted binding affinity. A total of 1532 peptides were tested for their ability to elicit a specific T-cell response by following the production of IFNγ from splenocytes isolated from vaccinated mice. Altogether, the screen resulted in 178 positive responders (11.8%), all novel Y. pestis CTL epitopes. These epitopes span 113 Y. pestis proteins. Substantial enrichment of membrane-associated proteins was detected for epitopes selected from hotspots of predicted MHC binders. These results considerably expand the repertoire of known CTL epitopes in Y. pestis and pave the way to

NASA's Advanced Information Systems Technology (AIST) Program: Advanced Concepts and Disruptive Technologies

Science.gov (United States)

Little, M. M.; Moe, K.; Komar, G.

2014-12-01

NASA's Earth Science Technology Office (ESTO) manages a wide range of information technology projects under the Advanced Information Systems Technology (AIST) Program. The AIST Program aims to support all phases of NASA's Earth Science program with the goal of enabling new observations and information products, increasing the accessibility and use of Earth observations, and reducing the risk and cost of satellite and ground based information systems. Recent initiatives feature computational technologies to improve information extracted from data streams or model outputs and researchers' tools for Big Data analytics. Data-centric technologies enable research communities to facilitate collaboration and increase the speed with which results are produced and published. In the future NASA anticipates more small satellites (e.g., CubeSats), mobile drones and ground-based in-situ sensors will advance the state-of-the-art regarding how scientific observations are performed, given the flexibility, cost and deployment advantages of new operations technologies. This paper reviews the success of the program and the lessons learned. Infusion of these technologies is challenging and the paper discusses the obstacles and strategies to adoption by the earth science research and application efforts. It also describes alternative perspectives for the future program direction and for realizing the value in the steps to transform observations from sensors to data, to information, and to knowledge, namely: sensor measurement concepts development; data acquisition and management; data product generation; and data exploitation for science and applications.

Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice

DEFF Research Database (Denmark)

Thomsen, Allan Randrup; Johansen, J; Marker, O

1996-01-01

To study the contribution of CD4+ T cells and B cells to antiviral immunity and long term virus control, MHC class II-deficient and B cell-deficient mice were infected with lymphocytic choriomeningitis virus. In class II-deficient mice, which lack CD4+ T cells, the primary CTL response is virtually...... this phenomenon could reflect participation of B cells and/or Abs in long term virus control, similar experiments were performed with mice that do not have mature B cells because of a disrupted membrane exon of the mu chain gene. In these mice, the cell-mediated immune response was slightly delayed, but transient...... and that in their absence, the virus-specific CTL potential becomes exhausted. Together our results indicate that while CD8+ cells play a dominant role in acute virus control, all three major components of the immune system are required for long term virus control....

Design Concept of Advanced Sodium-Cooled Fast Reactor and Related R&D in Korea

Directory of Open Access Journals (Sweden)

Yeong-il Kim

2013-01-01

Full Text Available Korea imports about 97% of its energy resources due to a lack of available energy resources. In this status, the role of nuclear power in electricity generation is expected to become more important in future years. In particular, a fast reactor system is one of the most promising reactor types for electricity generation, because it can utilize efficiently uranium resources and reduce radioactive waste. Acknowledging the importance of a fast reactor in a future energy policy, the long-term advanced SFR development plan was authorized by KAEC in 2008 and updated in 2011 which will be carried out toward the construction of an advanced SFR prototype plant by 2028. Based upon the experiences gained during the development of the conceptual designs for KALIMER, KAERI recently developed advanced sodium-cooled fast reactor (SFR design concepts of TRU burner that can better meet the generation IV technology goals. The current status of nuclear power and SFR design technology development program in Korea will be discussed. The developments of design concepts including core, fuel, fluid system, mechanical structure, and safety evaluation have been performed. In addition, the advanced SFR technologies necessary for its commercialization and the basic key technologies have been developed including a large-scale sodium thermal-hydraulic test facility, super-critical Brayton cycle system, under-sodium viewing techniques, metal fuel development, and developments of codes, and validations are described as R&D activities.

Study of advanced composite structural design concepts for an arrow wing supersonic cruise configuration, task 3

Science.gov (United States)

1978-01-01

A structural design study was conducted to assess the relative merits of structural concepts using advanced composite materials for an advanced supersonic aircraft cruising at Mach 2.7. The configuration and structural arrangement developed during Task I and II of the study, was used as the baseline configuration. Allowable stresses and strains were established for boron and advanced graphite fibers based on projected fiber properties available in the next decade. Structural concepts were designed and analyzed using graphite polyimide and boron polyimide, applied to stiffened panels and conventional sandwich panels. The conventional sandwich panels were selected as the structural concept to be used on the wing structure. The upper and lower surface panels of the Task I arrow wing were redesigned using high-strength graphite polyimide sandwich panels over the titanium spars and ribs. The ATLAS computer system was used as the basis for stress analysis and resizing the surface panels using the loads from the Task II study, without adjustment for change in aeroelastic deformation. The flutter analysis indicated a decrease in the flutter speed compared to the baseline titanium wing design. The flutter analysis indicated a decrease in the flutter speed compared to the baseline titanium wing design. The flutter speed was increased to that of the titanium wing, with a weight penalty less than that of the metallic airplane.

Core Thermal-Hydraulic Conceptual Design for the Advanced SFR Design Concepts

International Nuclear Information System (INIS)

Cho, Chung Ho; Chang, Jin Wook; Yoo, Jae Woon; Song, Hoon; Choi, Sun Rock; Park, Won Seok; Kim, Sang Ji

2010-01-01

The Korea Atomic Energy Research Institute (KAERI) has developed the advanced SFR design concepts from 2007 to 2009 under the National longterm Nuclear R and D Program. Two types of core designs, 1,200 MWe breakeven and 600 MWe TRU burner core have been proposed and evaluated whether they meet the design requirements for the Gen IV technology goals of sustainability, safety and reliability, economics, proliferation resistance, and physical protection. In generally, the core thermal hydraulic design is performed during the conceptual design phase to efficiently extract the core thermal power by distributing the appropriate sodium coolant flow according to the power of each assembly because the conventional SFR core is composed of hundreds of ducted assemblies with hundreds of fuel rods. In carrying out the thermal and hydraulic design, special attention has to be paid to several performance parameters in order to assure proper performance and safety of fuel and core; the coolant boiling, fuel melting, structural integrity of the components, fuel-cladding eutectic melting, etc. The overall conceptual design procedure for core thermal and hydraulic conceptual design, i.e., flow grouping and peak pin temperature calculations, pressure drop calculations, steady-state and detailed sub-channel analysis is shown Figure 1. In the conceptual design phase, results of core thermal-hydraulic design for advanced design concepts, the core flow grouping, peak pin cladding mid-wall temperature, and pressure drop calculations, are summarized in this study

Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

Science.gov (United States)

Crabtree, John; Zhang, Xihui

2015-01-01

Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We…

The Effects of Using Concept Mapping for Improving Advanced Level Biology Students' Lower- and Higher-Order Cognitive Skills

Science.gov (United States)

Bramwell-Lalor, Sharon; Rainford, Marcia

2014-01-01

This paper reports on teachers' use of concept mapping as an alternative assessment strategy in advanced level biology classes and its effects on students' cognitive skills on selected biology concepts. Using a mixed methods approach, the study employed a pre-test/post-test quasi-experimental design involving 156 students and 8 teachers from…

Advanced Gas Storage Concepts: Technologies for the Future

Energy Technology Data Exchange (ETDEWEB)

Freeway, Katy (PB-KBB Inc.); Rogers, R.E. (Mississippi State University); DeVries, Kerry L.; Nieland, Joel D.; Ratigan, Joe L.; Mellegard, Kirby D. (RESPEC)

2000-02-01

This full text product includes: 1) A final technical report titled Advanced Underground Gas Storage Concepts, Refrigerated-Mined Cavern Storage and presentations from two technology transfer workshops held in 1998 in Houston, Texas, and Pittsburgh, Pennsylvania (both on the topic of Chilled Gas Storage in Mined Caverns); 2) A final technical report titled Natural Gas Hydrates Storage Project, Final Report 1 October 1997 - 31 May 1999; 3) A final technical report titled Natural Gas Hydrates Storage Project Phase II: Conceptual Design and Economic Study, Final Report 9 June - 10 October 1999; 4) A final technical report titled Commerical Potential of Natural Gas Storage in Lined Rock Caverns (LRC) and presentations from a DOE-sponsored workshop on Alternative Gas Storage Technologies, held Feb 17, 2000 in Pittsburgh, PA; and 5) Phase I and Phase II topical reports titled Feasibility Study for Lowering the Minimum Gas Pressure in Solution-Mined Caverns Based on Geomechanical Analyses of Creep-Induced Damage and Healing.

An Exploration of Learners' Conceptions of Language, Culture, and Learning in Advanced-Level Spanish Courses

Science.gov (United States)

Drewelow, Isabelle; Mitchell, Claire

2015-01-01

This article reports on an exploratory study, which examines learners' rating of culture in relation to other concepts in advanced Spanish courses and their justification of the ratings attributed. Open-ended responses, elicited from a questionnaire completed by 179 respondents, were analysed line by line using an interpretive approach. Data…

Work Domain Analysis Methodology for Development of Operational Concepts for Advanced Reactors

Energy Technology Data Exchange (ETDEWEB)

Hugo, Jacques [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-05-01

This report describes a methodology to conduct a Work Domain Analysis in preparation for the development of operational concepts for new plants. This method has been adapted from the classical method described in the literature in order to better deal with the uncertainty and incomplete information typical of first-of-a-kind designs. The report outlines the strategy for undertaking a Work Domain Analysis of a new nuclear power plant and the methods to be used in the development of the various phases of the analysis. Basic principles are described to the extent necessary to explain why and how the classical method was adapted to make it suitable as a tool for the preparation of operational concepts for a new nuclear power plant. Practical examples are provided of the systematic application of the method and the various presentation formats in the operational analysis of advanced reactors.

Regulation of CTL responses to MHC-restricted class I peptide of the gp70 tumour antigen by splenic parenchymal CD4+ T cells in mice failing immunotherapy with DISC-mGM-CSF.

Science.gov (United States)

Ahmad, Murrium; Rees, Robert C; McArdle, Stephanie E; Li, Geng; Mian, Shahid; Entwisle, Claire; Loudon, Peter; Ali, Selman A

2005-07-20

Direct intratumour injection of the disabled infectious single-cycle-herpes simplex virus-encoding murine granulocyte/macrophage colony-stimulating factor (DISC-HSV-mGM-CSF) into established colon carcinoma CT26 tumours induced complete tumour rejection in up to 70% of treated animals (regressors), while the remaining mice developed progressive tumours (progressors). This murine Balb/c model was used to dissect the cellular mechanisms involved in tumour regression or progression following immunotherapy. CTLs were generated by coculturing lymphocytes and parenchymal cells from the same spleens of individual regressor or progressor animals in the presence of the relevant AH-1 peptide derived from the gp70 tumour-associated antigens expressed by CT26 tumours. Tumour regression was correlated with potent CTL responses, spleen weight and cytokine (IFN-gamma) production. Conversely, progressor splenocytes exhibited weak to no CTL activity and poor IFN-gamma production, concomitant with the presence of a suppressor cell population in the progressor splenic parenchymal cell fraction. Further fractionation of this parenchymal subpopulation demonstrated that cells inhibitory to the activation of AH-1-specific CTLs, restimulated in vitro with peptide, were present in the nonadherent parenchymal fraction. In vitro depletion of progressor parenchymal CD3+/CD4+ T cells restored the CTL response of the cocultured splenocytes (regressor lymphocytes and progressor parenchymal cells) and decreased the production of IL-10, suggesting that CD3+CD4+ T lymphocytes present in the parenchymal fraction regulated the CTL response to AH-1. We examined the cellular responses associated with tumour rejection and progression, identifying regulatory pathways associated with failure to respond to immunotherapy. Copyright 2005 Wiley-Liss, Inc.

Feasibility of a Networked Air Traffic Infrastructure Validation Environment for Advanced NextGen Concepts

Science.gov (United States)

McCormack, Michael J.; Gibson, Alec K.; Dennis, Noah E.; Underwood, Matthew C.; Miller,Lana B.; Ballin, Mark G.

2013-01-01

Abstract-Next Generation Air Transportation System (NextGen) applications reliant upon aircraft data links such as Automatic Dependent Surveillance-Broadcast (ADS-B) offer a sweeping modernization of the National Airspace System (NAS), but the aviation stakeholder community has not yet established a positive business case for equipage and message content standards remain in flux. It is necessary to transition promising Air Traffic Management (ATM) Concepts of Operations (ConOps) from simulation environments to full-scale flight tests in order to validate user benefits and solidify message standards. However, flight tests are prohibitively expensive and message standards for Commercial-off-the-Shelf (COTS) systems cannot support many advanced ConOps. It is therefore proposed to simulate future aircraft surveillance and communications equipage and employ an existing commercial data link to exchange data during dedicated flight tests. This capability, referred to as the Networked Air Traffic Infrastructure Validation Environment (NATIVE), would emulate aircraft data links such as ADS-B using in-flight Internet and easily-installed test equipment. By utilizing low-cost equipment that is easy to install and certify for testing, advanced ATM ConOps can be validated, message content standards can be solidified, and new standards can be established through full-scale flight trials without necessary or expensive equipage or extensive flight test preparation. This paper presents results of a feasibility study of the NATIVE concept. To determine requirements, six NATIVE design configurations were developed for two NASA ConOps that rely on ADS-B. The performance characteristics of three existing in-flight Internet services were investigated to determine whether performance is adequate to support the concept. Next, a study of requisite hardware and software was conducted to examine whether and how the NATIVE concept might be realized. Finally, to determine a business case

Advanced transportation system study: Manned launch vehicle concepts for two way transportation system payloads to LEO

Science.gov (United States)

Duffy, James B.

1993-01-01

The purpose of the Advanced Transportation System Study (ATSS) task area 1 study effort is to examine manned launch vehicle booster concepts and two-way cargo transfer and return vehicle concepts to determine which of the many proposed concepts best meets NASA's needs for two-way transportation to low earth orbit. The study identified specific configurations of the normally unmanned, expendable launch vehicles (such as the National Launch System family) necessary to fly manned payloads. These launch vehicle configurations were then analyzed to determine the integrated booster/spacecraft performance, operations, reliability, and cost characteristics for the payload delivery and return mission. Design impacts to the expendable launch vehicles which would be required to perform the manned payload delivery mission were also identified. These impacts included the implications of applying NASA's man-rating requirements, as well as any mission or payload unique impacts. The booster concepts evaluated included the National Launch System (NLS) family of expendable vehicles and several variations of the NLS reference configurations to deliver larger manned payload concepts (such as the crew logistics vehicle (CLV) proposed by NASA JSC). Advanced, clean sheet concepts such as an F-1A engine derived liquid rocket booster (LRB), the single stage to orbit rocket, and a NASP-derived aerospace plane were also included in the study effort. Existing expendable launch vehicles such as the Titan 4, Ariane 5, Energia, and Proton were also examined. Although several manned payload concepts were considered in the analyses, the reference manned payload was the NASA Langley Research Center's HL-20 version of the personnel launch system (PLS). A scaled up version of the PLS for combined crew/cargo delivery capability, the HL-42 configuration, was also included in the analyses of cargo transfer and return vehicle (CTRV) booster concepts. In addition to strictly manned payloads, two-way cargo

BALANCED SCORECARD AS AN ADVANCED MANAGEMENT CONCEPT WITHIN THE INTEGRATED QUALITY MANAGEMENT MODEL

Directory of Open Access Journals (Sweden)

Stevan Zivojinovic

2008-03-01

Full Text Available The significance of >Integratedquality management< (IQM model, originating form St.Gallen-model, is reflected in the need for synergic application of new and advanced concepts of management theory and practise. Balanced score card (BSC within IQM model becomes a catalyst of business success for a modern organization by focusing on organizational variables-business strategy, organization structure and corporate culture. BSC is the leading system of performance tracking and strategy implementation, consistent with other management concepts and methods for managing process improvement. Through BSC, IQM processes' activities correlate with organization business results. BSC management processes enable integration of all decision-making levels, from institutional via strategic to operative, in the process starting from planing, i.e. formulating and implementation of strategy, to feed back by performance measurement and control.

Detection of choline transporter-like 1 protein CTL1 in neuroblastoma × glioma cells and in the CNS, and its role in choline uptake

Czech Academy of Sciences Publication Activity Database

Machová, Eva; O´Regan, S.; Newcombe, J.; Meunier, F. M.; Prentice, J.; Dove, R.; Lisá, Věra; Doležal, Vladimír

2009-01-01

Roč. 110, č. 4 (2009), s. 1297-1309 ISSN 0022-3042 R&D Projects: GA MŠk(CZ) LC554; GA AV ČR(CZ) IAA500110703 Institutional research plan: CEZ:AV0Z50110509 Keywords : CTL1 * choline * cell growth Subject RIV: ED - Physiology Impact factor: 3.999, year: 2009

Improvement of environmental aspects of thermal power plant operation by advanced control concepts

Directory of Open Access Journals (Sweden)

Mikulandrić Robert

2012-01-01

Full Text Available The necessity of the reduction of greenhouse gas emissions, as formulated in the Kyoto Protocol, imposes the need for improving environmental aspects of existing thermal power plants operation. Improvements can be reached either by efficiency increment or by implementation of emission reduction measures. Investments in refurbishment of existing plant components or in plant upgrading by flue gas desulphurization, by primary and secondary measures of nitrogen oxides reduction, or by biomass co-firing, are usually accompanied by modernisation of thermal power plant instrumentation and control system including sensors, equipment diagnostics and advanced controls. Impact of advanced control solutions implementation depends on technical characteristics and status of existing instrumentation and control systems as well as on design characteristics and actual conditions of installed plant components. Evaluation of adequacy of implementation of advanced control concepts is especially important in Western Balkan region where thermal power plants portfolio is rather diversified in terms of size, type and commissioning year and where generally poor maintenance and lack of investments in power generation sector resulted in high greenhouse gases emissions and low efficiency of plants in operation. This paper is intended to present possibilities of implementation of advanced control concepts, and particularly those based on artificial intelligence, in selected thermal power plants in order to increase plant efficiency and to lower pollutants emissions and to comply with environmental quality standards prescribed in large combustion plant directive. [Acknowledgements. This paper has been created within WBalkICT - Supporting Common RTD actions in WBCs for developing Low Cost and Low Risk ICT based solutions for TPPs Energy Efficiency increasing, SEE-ERA.NET plus project in cooperation among partners from IPA SA - Romania, University of Zagreb - Croatia and Vinca

Advance directives in english and French law: different concepts, different values, different societies.

Science.gov (United States)

Horn, Ruth Judith

2014-03-01

In Western societies advance directives are widely recognised as important means to extend patient self-determination under circumstances of incapacity. Following other countries, England and France have adopted legislation aiming to clarify the legal status of advance directives. In this paper, I will explore similarities and differences in both sets of legislation, the arguments employed in the respective debates and the socio-political structures on which these differences are based. The comparison highlights how different legislations express different concepts emphasising different values accorded to the duty to respect autonomy and to protect life, and how these differences are informed by different socio-political contexts. Furthermore each country associates different ethical concerns with ADs which raise doubts about whether these directives are a theoretical idea which is hardly applicable in practice.

Advanced Concepts, Technologies and Flight Experiments for NASA's Earth Science Enterprise

Science.gov (United States)

Meredith, Barry D.

2000-01-01

Over the last 25 years, NASA Langley Research Center (LaRC) has established a tradition of excellence in scientific research and leading-edge system developments, which have contributed to improved scientific understanding of our Earth system. Specifically, LaRC advances knowledge of atmospheric processes to enable proactive climate prediction and, in that role, develops first-of-a-kind atmospheric sensing capabilities that permit a variety of new measurements to be made within a constrained enterprise budget. These advances are enabled by the timely development and infusion of new, state-of-the-art (SOA), active and passive instrument and sensor technologies. In addition, LaRC's center-of-excellence in structures and materials is being applied to the technological challenges of reducing measurement system size, mass, and cost through the development and use of space-durable materials; lightweight, multi-functional structures; and large deployable/inflatable structures. NASA Langley is engaged in advancing these technologies across the full range of readiness levels from concept, to components, to prototypes, to flight experiments, and on to actual science mission infusion. The purpose of this paper is to describe current activities and capabilities, recent achievements, and future plans of the integrated science, engineering, and technology team at Langley Research Center who are working to enable the future of NASA's Earth Science Enterprise.

The conception of disability and mental illness in advanced welfare states

DEFF Research Database (Denmark)

Ringø, Pia; Høgsbro, Kjeld

2017-01-01

The chapter presents historical developments in the conception of disability and services for people with disability and mental illness. It identifies the social, political and technological movements, which have led to the epistemologies that exist in this field today. The diverse understandings...... of mental problems and vulnerability have all through history motivated different guidelines for social work practice when it comes to people with cognitive and mental deficits and in the final section of the chapter, we discuss how current sociological, neurological, and psychiatric perspectives...... in research as well as clinical experiences from advanced welfare services might support a new model for understanding mental vulnerability....

Concept design and cluster control of advanced space connectable intelligent microsatellite

Science.gov (United States)

Wang, Xiaohui; Li, Shuang; She, Yuchen

2017-12-01

In this note, a new type of advanced space connectable intelligent microsatellite is presented to extend the range of potential application of microsatellite and improve the efficiency of cooperation. First, the overall concept of the micro satellite cluster is described, which is characterized by autonomously connecting with each other and being able to realize relative rotation through the external interfaces. Second, the multi-satellite autonomous assembly algorithm and control algorithm of the cluster motion are developed to make the cluster system combine into a variety of configurations in order to achieve different types of functionality. Finally, the design of the satellite cluster system is proposed, and the possible applications are discussed.

Conceptual design study advanced concepts test (ACT) facility

Energy Technology Data Exchange (ETDEWEB)

Zaloudek, F.R.

1978-09-01

The Advanced Concepts Test (ACT) Project is part of program for developing improved power plant dry cooling systems in which ammonia is used as a heat transfer fluid between the power plant and the heat rejection tower. The test facility will be designed to condense 60,000 lb/hr of exhaust steam from the No. 1 turbine in the Kern Power Plant at Bakersfield, CA, transport the heat of condensation from the condenser to the cooling tower by an ammonia phase-change heat transport system, and dissipate this heat to the environs by a dry/wet deluge tower. The design and construction of the test facility will be the responsibility of the Electric Power Research Institute. The DOE, UCC/Linde, and the Pacific Northwest Laboratories will be involved in other phases of the project. The planned test facilities, its structures, mechanical and electrical equipment, control systems, codes and standards, decommissioning requirements, safety and environmental aspects, and energy impact are described. Six appendices of related information are included. (LCL)

Advanced divertor concepts

International Nuclear Information System (INIS)

Ohyabu, N.; Komori, A.; Sagara, A.; Suzuki, H.; Morisaki, T.; Masuzaki, S.; Watanabe, T.; Noda, N.; Motojima, O.

1996-01-01

LHD divertor development program has generated various innovative divertor concepts and technologies which will help to improve the plasma performance in both helical and tokamak devices. They are two divertor operational scenarios (confinement improvement by generating high temperature divertor plasma and simultaneous achievement of radiative cooling and H-mode-like confinement improvement). Local island divertor geometry has also been proposed. This new divertor has been successfully tested in the CHS device and is planned to be installed in the LHD device. In addition, technological development of new efficient hydrogen pumping schemes (carbon sheet pump and membrane pump) are being pursued for enhancement of the divertor control capability. 17 refs., 8 figs

Rejection of large HPV-16 expressing tumors in aged mice by a single immunization of VacciMax® encapsulated CTL/T helper peptides

Directory of Open Access Journals (Sweden)

MacDonald Lisa

2007-06-01

Full Text Available Abstract The incidence of cancer increases significantly in later life, yet few pre-clinical studies of cancer immunotherapy use mice of advanced age. A novel vaccine delivery platform (VacciMax®,VM is described that encapsulates antigens and adjuvants in multilamellar liposomes in a water-in-oil emulsion. The therapeutic potential of VM-based vaccines administered as a single dose was tested in HLA-A2 transgenic mice of advanced age (48–58 weeks old bearing large palpable TC1/A2 tumors. The VM-based vaccines contained one or more peptides having human CTL epitopes derived from HPV 16 E6 and E7. VM formulations contained a single peptide, a mixture of four peptides or the same four peptides linked together in a single long peptide. All VM formulations contained PADRE and CpG as adjuvants and ISA51 as the hydrophobic component of the water-in-oil emulsion. VM-formulated vaccines containing the four peptides as a mixture or linked together in one long peptide eradicated 19-day old established tumors within 21 days of immunization. Peptide-specific cytotoxic cellular responses were confirmed by ELISPOT and intracellular staining for IFN-γ producing CD8+ T cells. Mice rendered tumor-free by vaccination were re-challenged in the opposite flank with 10 million HLF-16 tumor cells, another HLA-A2/E6/E7 expressing tumor cell line. None of these mice developed tumors following the re-challenge. In summary, this report describes a VM-formulated therapeutic vaccine with the following unprecedented outcome: a eradication of large tumors (> 700 mm3 b in mice of advanced age c in less than three weeks post-immunization d following a single vaccination.

PENERAPAN CTL (CONTEXTUAL TEACHING AND LEARNING MENGGUNAKAN MEDIA AJAR KLIPING UNTUK MENINGKATKAN PRESTASI BELAJAR, KOMPETENSI DASAR "MENEMUKAN PELUANG BARU DARI PELANGGAN" KELAS XI PEMASARAN SMK N 1 JAPARA KABUPATEN KUNINGAN

Directory of Open Access Journals (Sweden)

Marlina

2012-05-01

-rata skor sebesar 66,45 dan termasuk dalam kategori rendah. Tes siklus II menunjukkan skor rata-rata sebesar 73,71 dan termasuk dalam kategori tinggi. Jadi, telah terjadi peningkatan dari siklus I ke siklus II sebesar 7,3 atau sebesar 10,9%. Perolehan hasil ini menunjukkan bahwa pembelajaran kompetensi dasar menemukan peluang baru dari pelanggan dengan model pembelajaran Kontekstual berbantuan media kliping telah berhasil. CTL is a concept of learning in which the teachers bring a real world situations in the classroom and encourage the students to make connections between the knowledge that they have and its application in the life, while the students gain the knowledge bit by bit, and from the process of constructing themselves, as a basis to solve problems in their life. From the result of the first observation class XI Marketing SMK Negeri 1 Japara, obtained that on the implementation of learning basic competence discovering New Opportunities from customers was less developed, it was because the learning process only occured in one direction or focused only on the teacher, namely, using conventional learning, while the average value of the midterm test of academic year 2010 was 60.32 where there were 14 students whose values ??did not meet the Criteria of Minimum Completeness (KKM. The Problem in this study is "What is CTL learning Model (Contextual Teaching Learning assisted clippings media can improve student learning achievement on basic competence discovering new opportunities from customer class XI Marketing SMK Negeri 1 Japara?". The purpose of this study is to find out the effectiveness of clippings media with CTL learning model to improve student leaning achievement of basic competence discovering new opportunities from customers Class XI Marketing SMK Negeri 1 Japara Kuningan District. The subject of this study is the student of SMK Negeri 1 Japara that consists of �2 male students and 29 female students. The study is done in 2 cycles, namely, cycle I and

Isolation of antigenic substances from HIV-1 envelope gp160 gene transfectants by mild acid elution and X-irradiation treatment. For the development of CTL-based immunotherapy

International Nuclear Information System (INIS)

Fujimoto, Chiaki; Nakagawa, Yohko; Shimizu, Masumi; Ohara, Kunitoshi; Takahashi, Hidemi

2003-01-01

Cytotoxic T lymphocytes (CTLs) play a central role in a broad spectrum of tumor immunity. Such CTLs generally recognize processed antigenic fragments in association with class I major histocompatibility complex (MHC) molecules. Thus, it is important to identify naturally processed antigens associated with class I MHC molecules to generate and activate antigen-specific CTLs. Those processed antigens fitted in the groove of class I MHC molecules are fixed by the β2-microglobulin. Mild acid elution is one method used to isolate antigenic fragments from class I MHC molecules on tumor cells by unfastening a clasp of β2-microglobulin, a critical component for stabilizing class I MHC molecules on the cell surface. Indeed, after the mild acid treatment, the expression of class I MHC molecules was temporarily down-modulated and a strong antigenic fraction for CTL recognition was obtained. To our surprise, such down-modulation of class I MHC molecule expression was also observed when the tumor cells were irradiated. Therefore, using human immunodeficiency virus type I (HIV-1) gp160 env gene transfectants, we examined the effect of X-irradiation on releasing the loaded antigenic fragments. Functional extracts were obtained from X-irradiated cell supernatants that sensitized syngeneic fibroblasts for specific CTL recognition, suggesting that X-irradiation extracts would also contain known antigenic epitopes. These results indicate that, in addition to the conventional mild acid elution treatment, X-irradiation method shown in this paper may provide a new approach for CTL-based vaccine development via isolating antigenic molecules from various tumors or virally infected cells. (author)

Surgical treatment of severe osteoporosis including new concept of advanced severe osteoporosis

Directory of Open Access Journals (Sweden)

Jin Hwan Kim

2017-12-01

Full Text Available Severe osteoporosis is classified as those with a bone mineral density (BMD T-score of −2.5 or lower, and demonstrate one or more of osteoporotic, low-trauma, fragility fractures. According to the general principle of surgical approach, patients with severe osteoporosis require not only more thorough pre- and postoperative treatment plans, but improvements in surgical fixtures and techniques such as the concept of a locking plate to prevent bone deformity and maximizing the blood flow to the fracture site by using a minimally invasive plate osteosynthesis. Arthroplasty is often performed in cases of displaced femoral neck fracture. Otherwise internal fixation for the goal of bone union is the generally accepted option for intertrochanteric, subtrochanteric, and femoral shaft fractures. Most of osteoporotic spine fracture is stable compression fracture, but vertebroplasty or kyphoplasty may be performed some selective patients. If neurological paralysis, severe spinal instability, or kyphotic deformity occurs, open decompression or fusion surgery may be considered. In order to overcome shortcomings of the World Health Organization definition of osteoporosis, we proposed a concept of ‘advanced severe osteoporosis,’ which is defined by the presence of proximal femur fragility fracture or two or more fragility fractures in addition to BMD T-score of −2.5 or less. In conclusion, we need more meticulous approach for surgical treatment of severe osteoporosis who had fragility fracture. In cases of advanced severe osteoporosis, we recommend more aggressive managements using parathyroid hormone and receptor activator of nuclear factor kappa-B ligand monoclonal antibody.

Advances in the self-burial concept for deep geological disposal of radioactive waste

International Nuclear Information System (INIS)

Logan, S.E.

1996-01-01

The self-burial concept for deep geological disposal of high-level radioactive waste seeks to utilize the radioactive decay heat emitted by the wastes to melt rock and allow descent by gravity into crystalline rock for isolation. Logan developed the governing equations for the self-disposal process in a paper published in 1973 and 1974 showing that moderate waste concentrations in capsules 1 to 2 m in diameter could descend through granite or basalt to considerable depths, in some cases grater than 10 km. Safety considerations related to filling, handling, and initial cooling of such large capsules prior to release, plus the severe container material environment, has prevented use of the concept. Byalko in Russia recently proposed using a sulfur-filled borehole as a conduit for conveying small capsules down to an accumulation zone at a safe depth of several kilometers. This advance in the self-burial concept overcomes previous problems with self-burial. First, capsules of 0.3 m or less in diameter are relatively simple to fill and handle. Second, investigations indicate that once emplaced at an initial accumulation depth, rock-melting can proceed without an enveloping waste container

Advanced Technology Subsonic Transport Study: N+3 Technologies and Design Concepts

Science.gov (United States)

Raymer, Daniel P.; Wilson, Jack; Perkins, H. Douglas; Rizzi, Arthur; Zhang, Mengmeng; RamirezPuentes, Alfredo

2011-01-01

Conceptual Research Corporation, the Science of the Possible, has completed a two-year study of concepts and technologies for future airliners in the 180-passenger class. This NASA-funded contract was primarily focused on the ambitious goal of a 70 percent reduction in fuel consumption versus the market-dominating Boeing 737-800. The study is related to the N+3 contracts awarded in 2008 by NASA s Aeronautics Research Mission Directorate to teams led by Boeing, GE Aviation, MIT, and Northrop Grumman, but with more modest goals and funding. CRC s contract featured a predominant emphasis on propulsion and fuel consumption, but since fuel consumption depends upon air vehicle design as much as on propulsion technology, the study included notional vehicle design, analysis, and parametric studies. Other NASA goals including NOx and noise reduction are of long-standing interest but were not highlighted in this study, other than their inclusion in the propulsion system provided to CRC by NASA. The B-737-800 was used as a benchmark, parametric tool, and design point of departure. It was modeled in the RDS-Professional aircraft design software then subjected to extensive parametric variations of parasitic drag, drag-due-to-lift, specific fuel consumption, and unsized empty weight. These studies indicated that the goal of a 70 percent reduction in fuel consumption could be attained with roughly a 30 percent improvement in all four parameters. The results were then fit to a Response Surface and coded for ease of use in subsequent trade studies. Potential technologies to obtain such savings were identified and discussed. More than 16 advanced concept designs were then prepared, attempting to investigate almost every possible emerging concept for application to this class airliner. A preliminary assessment of these concepts was done based on their total wetted area after design normalization of trimmed maximum lift. This assessment points towards a Tailless Airliner concept which

Study of advanced fuel system concepts for commercial aircraft and engines

Science.gov (United States)

Versaw, E. F.; Brewer, G. D.; Byers, W. D.; Fogg, H. W.; Hanks, D. E.; Chirivella, J.

1983-01-01

The impact on a commercial transport aircraft of using fuels which have relaxed property limits relative to current commercial jet fuel was assessed. The methodology of the study is outlined, fuel properties are discussed, and the effect of the relaxation of fuel properties analyzed. Advanced fuel system component designs that permit the satisfactory use of fuel with the candidate relaxed properties in the subject aircraft are described. The two fuel properties considered in detail are freezing point and thermal stability. Three candidate fuel system concepts were selected and evaluated in terms of performance, cost, weight, safety, and maintainability. A fuel system that incorporates insulation and electrical heating elements on fuel tank lower surfaces was found to be most cost effective for the long term.

HIV-1 Gag-specific exosome-targeted T cell-based vaccine stimulates effector CTL responses leading to therapeutic and long-term immunity against Gag/HLA-A2-expressing B16 melanoma in transgenic HLA-A2 mice

Directory of Open Access Journals (Sweden)

Rong Wang

2014-01-01

Full Text Available Human immunodeficiency virus type-1 (HIV-1-specific dendritic cell (DC vaccines have been applied to clinical trials that show only induction of some degree of immune responses, warranting the search of other more efficient vaccine strategies. Since HIV-1-specific CD8+ cytotoxic T lymphocytes (CTLs have been found to recognize some HIV-1 structural protein Gag conserved and cross-strain epitopes, Gag has become one of the most attractive target candidates for HIV-1 vaccine development. In this study, we generated HIV-1 Gag-specific Gag-Texo vaccine by using ConA-stimulated polyclonal CD8+ T-cells with uptake of Gag-expressing adenoviral vector AdVGag-transfected DC (DCGag-released exosomes (EXOs, and assessed its stimulation of Gag-specific CD8+ CTL responses and antitumor immunity. We demonstrate that Gag-Texo and DCGag vaccines comparably stimulate Gag-specific effector CD8+ CTL responses. Gag-Texo-stimulated CTL responses result in protective immunity against Gag-expressing BL6-10Gag melanoma in 8/8 wild-type C57BL/6 mice. In addition, we show that Gag-Texo vaccine also induces CTL responses leading to protective and long-term immunity against Gag/HLA-A2-expressing BL6-10Gag/A2 melanoma in 8/8 and 2/8 transgenic HLA-A2 mice, respectively. The average number of lung tumor colonies in mice with 30-days post-immunization is only 23, which is significantly less than that (>300 in control ConA-T-immunized HLA-A2 mice. Furthermore, Gag-Texo vaccine also induces some degree of therapeutic immunity. The average number (50 and size (0.23 mm in diameter of lung tumor colonies in Gag-Texo-immunized HLA-A2 mice bearing 6-day-established lung BL6-10Gag/A2 melanoma metastasis are significantly less than the average number (>300 and size (1.02 mm in diameter in control ConA-T-immunized HLA-A2 mice. Taken together, HIV-1 Gag-Texo vaccine capable of stimulating Gag-specific CTL responses and therapeutic immunity may be useful as a new immunotherapeutic

Camera Concepts for the Advanced Gamma-Ray Imaging System (AGIS)

Science.gov (United States)

Nepomuk Otte, Adam

2009-05-01

The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. The incorporation of trigger electronics and signal digitization into the camera are under study. Given the size of AGIS, the camera must be reliable, robust, and cost effective. We are investigating several directions that include innovative technologies such as Geiger-mode avalanche-photodiodes as a possible detector and switched capacitor arrays for the digitization.

Advanced reactor concepts and safety

International Nuclear Information System (INIS)

Lipsett, J.J.

1988-06-01

The need for some consistency in the terms used to describe the evolution of methods for ensuring the safety of nuclear reactors has been identified by the IAEA. This is timely since there appears to be a danger that the precision of many valuable words is being diluted and that a new jargon may appear that will confuse rather than aid the communication of important but possibly diverse philosophies and concepts. Among the difficulties faced by the nuclear industry is promoting and gaining a widespread understanding of the risks actually posed by nuclear reactors. In view of the importance of communication to both the public and to the technical community generally, the starting point for the definition of terms must be with dictionary meanings and common technical usage. The nuclear engineering community should use such words in conformance with the whole technical world. This paper addresses many of the issues suggested in the invitation to meet and also poses some additional issues for consideration. Some examples are the role of the operator in either enhancing or degrading safety and how the meaning or interpretation of the word 'safety' can be expected to change during the next few decades. It is advantageous to use criteria against which technologies and ongoing operating performance can be judged provided that the criteria are generic and not specific to particular reactor concepts. Some thoughts are offered on the need to frame the criteria carefully so that innovative solutions and concepts are fostered, not stifled

Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations

Energy Technology Data Exchange (ETDEWEB)

Hugo, Jacques [Idaho National Lab. (INL), Idaho Falls, ID (United States); Forester, John [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gertman, David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Joe, Jeffrey [Idaho National Lab. (INL), Idaho Falls, ID (United States); Medema, Heather [Idaho National Lab. (INL), Idaho Falls, ID (United States); Persensky, Julius [Idaho National Lab. (INL), Idaho Falls, ID (United States); Whaley, April [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2013-08-01

This report presents preliminary research results from the investigation into the development of new models and guidance for Concepts of Operations in advanced small modular reactor (AdvSMR) designs. AdvSMRs are nuclear power plants (NPPs), but unlike conventional large NPPs that are constructed on site, AdvSMRs systems and components will be fabricated in a factory and then assembled on site. AdvSMRs will also use advanced digital instrumentation and control systems, and make greater use of automation. Some AdvSMR designs also propose to be operated in a multi-unit configuration with a single central control room as a way to be more cost-competitive with existing NPPs. These differences from conventional NPPs not only pose technical and operational challenges, but they will undoubtedly also have regulatory compliance implications, especially with respect to staffing requirements and safety standards.

Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations

Energy Technology Data Exchange (ETDEWEB)

Jacques Hugo; John Forester; David Gertman; Jeffrey Joe; Heather Medema; Julius Persensky; April Whaley

2013-04-01

This report presents preliminary research results from the investigation in to the development of new models and guidance for concepts of operations (ConOps) in advanced small modular reactor (aSMR) designs. In support of this objective, three important research areas were included: operating principles of multi-modular plants, functional allocation models and strategies that would affect the development of new, non-traditional concept of operations, and the requiremetns for human performance, based upon work domain analysis and current regulatory requirements. As part of the approach for this report, we outline potential functions, including the theoretical and operational foundations for the development of a new functional allocation model and the identification of specific regulatory requirements that will influence the development of future concept of operations. The report also highlights changes in research strategy prompted by confirmationof the importance of applying the work domain analysis methodology to a reference aSMR design. It is described how this methodology will enrich the findings from this phase of the project in the subsequent phases and help in identification of metrics and focused studies for the determination of human performance criteria that can be used to support the design process.

Study of advanced composite structural design concepts for an arrow wing supersonic cruise configuration

Science.gov (United States)

Turner, M. J.; Grande, D. L.

1978-01-01

Based on estimated graphite and boron fiber properties, allowable stresses and strains were established for advanced composite materials. Stiffened panel and conventional sandwich panel concepts were designed and analyzed, using graphite/polyimide and boron/polyimide materials. The conventional sandwich panel was elected as the structural concept for the modified wing structure. Upper and lower surface panels of the arrow wing structure were then redesigned, using high strength graphite/polyimide sandwich panels, retaining the titanium spars and ribs from the prior study. The ATLAS integrated analysis and design system was used for stress analysis and automated resizing of surface panels. Flutter analysis of the hybrid structure showed a significant decrease in flutter speed relative to the titanium wing design. The flutter speed was increased to that of the titanium design by selective increase in laminate thickness and by using graphite fibers with properties intermediate between high strength and high modulus values.

Advanced Concepts for Pressure-Channel Reactors: Modularity, Performance and Safety

Science.gov (United States)

Duffey, Romney B.; Pioro, Igor L.; Kuran, Sermet

Based on an analysis of the development of advanced concepts for pressure-tube reactor technology, we adapt and adopt the pressure-tube reactor advantage of modularity, so that the subdivided core has the potential for optimization of the core, safety, fuel cycle and thermal performance independently, while retaining passive safety features. In addition, by adopting supercritical water-cooling, the logical developments from existing supercritical turbine technology and “steam” systems can be utilized. Supercritical and ultra-supercritical boilers and turbines have been operating for some time in coal-fired power plants. Using coolant outlet temperatures of about 625°C achieves operating plant thermal efficiencies in the order of 45-48%, using a direct turbine cycle. In addition, by using reheat channels, the plant has the potential to produce low-cost process heat, in amounts that are customer and market dependent. The use of reheat systems further increases the overall thermal efficiency to 55% and beyond. With the flexibility of a range of plant sizes suitable for both small (400 MWe) and large (1400 MWe) electric grids, and the ability for co-generation of electric power, process heat, and hydrogen, the concept is competitive. The choice of core power, reheat channel number and exit temperature are all set by customer and materials requirements. The pressure channel is a key technology that is needed to make use of supercritical water (SCW) in CANDU®1 reactors feasible. By optimizing the fuel bundle and fuel channel, convection and conduction assure heat removal using passive-moderator cooling. Potential for severe core damage can be almost eliminated, even without the necessity of activating the emergency-cooling systems. The small size of containment structure lends itself to a small footprint, impacts economics and building techniques. Design features related to Canadian concepts are discussed in this paper. The main conclusion is that development of

Integrated Evaluation Concept to Assess the Efficacy of Advanced Wastewater Treatment Processes for the Elimination of Micropollutants and Pathogens.

Science.gov (United States)

Ternes, Thomas A; Prasse, Carsten; Eversloh, Christian Lütke; Knopp, Gregor; Cornel, Peter; Schulte-Oehlmann, Ulrike; Schwartz, Thomas; Alexander, Johannes; Seitz, Wolfram; Coors, Anja; Oehlmann, Jörg

2017-01-03

A multidisciplinary concept has been developed to compare advanced wastewater treatment processes for their efficacy of eliminating micropollutants and pathogens. The concept is based on (i) the removal/formation of selected indicator substances and their transformation products (TPs), (ii) the assessment of ecotoxicity via in vitro tests, and (iii) the removal of pathogens and antibiotic resistant bacteria. It includes substances passing biological wastewater treatment plants regulated or proposed to be regulated in the European Water Framework Directive, TPs formed in biological processes or during ozonation, agonistic/antagonistic endocrine activities, mutagenic/genotoxic activities, cytotoxic activities, further activities like neurotoxicity as well as antibiotics resistance genes, and taxonomic gene markers for pathogens. At a pilot plant, ozonation of conventionally treated wastewater resulted in the removal of micropollutants and pathogens and the reduction of estrogenic effects, whereas the in vitro mutagenicity increased. Subsequent post-treatment of the ozonated water by granular activated carbon (GAC) significantly reduced the mutagenic effects as well as the concentrations of remaining micropollutants, whereas this was not the case for biofiltration. The results demonstrate the suitability of the evaluation concept to assess processes of advanced wastewater treatment including ozonation and GAC by considering chemical, ecotoxicological, and microbiological parameters.

Advanced concepts for waste management and nuclear energy production in the EURATOM 5. framework programme

International Nuclear Information System (INIS)

Hugon, M.; Bhatnagar, V.P.; Martin Bermejon, J.

2002-01-01

This paper summarises the objectives of the research projects on partitioning and transmutation (P and T) of long-lived radionuclides in nuclear waste and advanced systems for nuclear energy production in the key action on nuclear fission of the EURATOM 5. Framework Programme (FP5) (1998-2002). As these FP5 projects cover the main aspects of P and T, they should provide a basis for evaluating the practicability, on an industrial scale, of P and T for reducing the amount of long-lived radionuclides to be disposed of. Concerning advanced concepts, a cluster of projects is addressing the key technical issues to be solved before implementing high-temperature reactors (HTRs) commercially for energy production. Finally, the European Commissions proposal fora New Framework Programme (2002-2006) is briefly outlined. (authors)

Advanced concepts for waste management and nuclear energy production in the EURATOM fifth framework programme

International Nuclear Information System (INIS)

Hugon, M.; Bhatnagar, V.P.; Martin Bermejo, J.

2001-01-01

This paper summarises the objectives of the research projects on Partitioning and Transmutation (P and T) of long lived radionuclides in nuclear waste and advanced systems for nuclear energy production in the key action on nuclear fission of the EURATOM Fifth Framework Programme (FP5) (1998-2002). As these FP5 projects cover the main aspects of P and T, they should provide a basis for evaluating the practicability, on an industrial scale, of P and T for reducing the amount of long lived radionuclides to be disposed of. Concerning advanced concepts, a cluster of projects is addressing the key technical issues to be solved before implementing High Temperature Reactors (HTRs) commercially for energy production. Finally, the European Commission(tm)s proposal for a New Framework Programme (2002-2006) is briefly outlined. (author)

Generic Repository Concepts and Thermal Analysis for Advanced Fuel Cycles - 12477

Energy Technology Data Exchange (ETDEWEB)

Hardin, Ernest [Sandia National Laboratories, P.O. Box 5800 MS 0736, Albuquerque, NM 87185 (United States); Blink, James [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551-0808 (United States); Carter, Joe [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States); Fratoni, Massimiliano; Greenberg, Harris; Sutton, Mark [Lawrence Livermore National Laboratory (United States); Howard, Robert [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States)

2012-07-01

A geologic disposal concept for spent nuclear fuel (SNF) or high-level waste (HLW) consists of three components: waste inventory, geologic setting, and concept of operations. A set of reference geologic disposal concepts has been developed by the U.S. Department of Energy (DOE), Used Fuel Disposition campaign. Reference concepts are identified for crystalline rock, clay/shale, bedded salt, and deep borehole (crystalline basement) geologic settings. These were analyzed for waste inventory cases representing a range of waste types that could be produced by advanced nuclear fuel cycles. Concepts of operation consisting of emplacement mode, repository layout, and engineered barrier descriptions, were selected based on international progress. All of these disposal concepts are enclosed emplacement modes, whereby waste packages are in direct contact with encapsulating engineered or natural materials. Enclosed modes have less capacity to dissipate heat than open modes such as that proposed for a repository at Yucca Mountain. Thermal analysis has identified important relationships between waste package size and capacity, and the duration of surface decay storage needed to meet temperature limits for different disposal concepts. For the crystalline rock and clay/shale repository concepts, a waste package surface temperature limit of 100 deg. C was assumed to prevent changes in clay-based buffer material or clay-rich host rock. Surface decay storage of 50 to 100 years is needed for disposal of high-burnup LWR SNF in 4-PWR packages, or disposal of HLW glass from reprocessing LWR uranium oxide (UOX) fuel. High-level waste (HLW) from reprocessing of metal fuel used in a fast reactor could be disposed after decay storage of 50 years or less. For disposal in salt the rock thermal conductivity is significantly greater, and higher temperatures (200 deg. C) can be tolerated at the waste package surface. Decay storage of 10 years or less is needed for high-burnup LWR SNF in 4-PWR

Conceptual design of advanced central receiver power systems sodium-cooled receiver concept. Volume 2, Book 2. Appendices. Final report

Energy Technology Data Exchange (ETDEWEB)

1979-03-01

The appendices include: (A) design data sheets and P and I drawing for 100-MWe commercial plant design, for all-sodium storage concept; (B) design data sheets and P and I drawing for 100-MWe commercial plant design, for air-rock bed storage concept; (C) electric power generating water-steam system P and I drawing and equipment list, 100-MWe commercial plant design; (D) design data sheets and P and I drawing for 281-MWe commercial plant design; (E) steam generator system conceptual design; (F) heat losses from solar receiver surface; (G) heat transfer and pressure drop for rock bed thermal storage; (H) a comparison of alternative ways of recovering the hydraulic head from the advanced solar receiver tower; (I) central receiver tower study; (J) a comparison of mechanical and electromagnetic sodium pumps; (K) pipe routing study of sodium downcomer; and (L) sodium-cooled advanced central receiver system simulation model. (WHK)

The Los Alamos Laser Acceleration of Particles Workshop and beginning of the advanced accelerator concepts field

Science.gov (United States)

Joshi, C.

2012-12-01

The first Advanced Acceleration of Particles-AAC-Workshop (actually named Laser Acceleration of Particles Workshop) was held at Los Alamos in January 1982. The workshop lasted a week and divided all the acceleration techniques into four categories: near field, far field, media, and vacuum. Basic theorems of particle acceleration were postulated (later proven) and specific experiments based on the four categories were formulated. This landmark workshop led to the formation of the advanced accelerator R&D program in the HEP office of the DOE that supports advanced accelerator research to this day. Two major new user facilities at Argonne and Brookhaven and several more directed experimental efforts were built to explore the advanced particle acceleration schemes. It is not an exaggeration to say that the intellectual breadth and excitement provided by the many groups who entered this new field provided the needed vitality to then recently formed APS Division of Beams and the new online journal Physical Review Special Topics-Accelerators and Beams. On this 30th anniversary of the AAC Workshops, it is worthwhile to look back at the legacy of the first Workshop at Los Alamos and the fine groundwork it laid for the field of advanced accelerator concepts that continues to flourish to this day.

Advanced Transportation System Studies. Technical Area 3: Alternate Propulsion Subsystem Concepts. Volume 1; Executive Summary

Science.gov (United States)

Levack, Daniel J. H.

2000-01-01

The Alternate Propulsion Subsystem Concepts contract had seven tasks defined that are reported under this contract deliverable. The tasks were: FAA Restart Study, J-2S Restart Study, Propulsion Database Development. SSME Upper Stage Use. CERs for Liquid Propellant Rocket Engines. Advanced Low Cost Engines, and Tripropellant Comparison Study. The two restart studies, F-1A and J-2S, generated program plans for restarting production of each engine. Special emphasis was placed on determining changes to individual parts due to obsolete materials, changes in OSHA and environmental concerns, new processes available, and any configuration changes to the engines. The Propulsion Database Development task developed a database structure and format which is easy to use and modify while also being comprehensive in the level of detail available. The database structure included extensive engine information and allows for parametric data generation for conceptual engine concepts. The SSME Upper Stage Use task examined the changes needed or desirable to use the SSME as an upper stage engine both in a second stage and in a translunar injection stage. The CERs for Liquid Engines task developed qualitative parametric cost estimating relationships at the engine and major subassembly level for estimating development and production costs of chemical propulsion liquid rocket engines. The Advanced Low Cost Engines task examined propulsion systems for SSTO applications including engine concept definition, mission analysis. trade studies. operating point selection, turbomachinery alternatives, life cycle cost, weight definition. and point design conceptual drawings and component design. The task concentrated on bipropellant engines, but also examined tripropellant engines. The Tripropellant Comparison Study task provided an unambiguous comparison among various tripropellant implementation approaches and cycle choices, and then compared them to similarly designed bipropellant engines in the

US long distance fiber optic networks: Technology, evolution and advanced concepts. Volume 3: Advanced networks and economics

Science.gov (United States)

1986-10-01

This study projects until 2000 the evolution of long distance fiber optic networks in the U.S. Volume 1 is the executive Summary. Volume 2 focuses on fiber optic components and systems that are directly related to the operation of long-haul networks. Optimistic, pessimistic and most likely scenarios of technology development are presented. The activities of national and regional companies implementing fiber long haul networks are also highlighted, along with an analysis of the market and regulatory forces affecting network evolution. Volume 3 presents advanced fiber optic network concept definitions. Inter-LATA traffic is quantified and forms the basis for the construction of 11-, 15-, 17-, and 23-node networks. Using the technology projections from Volume 2, a financial model identifies cost drivers and determines circuit mile costs between any two LATAs. A comparison of fiber optics with alternative transmission concludes the report.

Advanced Wind Turbine Drivetrain Concepts. Workshop Report

Energy Technology Data Exchange (ETDEWEB)

none,

2010-12-01

This report presents key findings from the Department of Energy’s Advanced Drivetrain Workshop, held on June 29-30, 2010, to assess different advanced drivetrain technologies, their relative potential to improve the state-of-the-art in wind turbine drivetrains, and the scope of research and development needed for their commercialization in wind turbine applications.

Inherent safe design of advanced high temperature reactors - concepts for future nuclear power plants

International Nuclear Information System (INIS)

Hodzic, A.; Kugeler, K.

1997-01-01

This paper discusses the applicable solutions for a commercial size High Temperature Reactor (HTR) with inherent safety features. It describes the possible realization using an advanced concept which combines newly proposed design characteristics with some well known and proven HTR inherent safety features. The use of the HTR technology offers the conceivably best solution to meet the legal criteria, recently stated in Germany, for the future reactor generation. Both systems, block and pebble bed ,reactor, could be under certain design conditions self regulating in terms of core nuclear heat, mechanical stability and the environmental transfer. 23 refs., 7 figs

Model Pembelajaran CTL (Contextual Teaching and Learning dalam Meningkatkan Hasil Belajar Mahasiswa PGSD Pada MataKuliah Konsep IPS Dasar

Directory of Open Access Journals (Sweden)

Wahyu Susiloningsih

2016-03-01

Full Text Available Hasil belajar adalah suatu proses perubahan tingkah laku dalam pengetahuan, sikap, dan ketrampilan yang diperoleh dalam jangka waktu yang lama.Mata kuliah Konsep IPS Dasar merupakan mata kuliah yang memberikan pemahaman kepada mahasiswa PGSD tentang konsep dasar IPS sebagai landasan kajian yang bahannya bersumber dari kehidupan manusia di masyarakat, yang aspek-aspeknya meliputi social science (ilmu sosial, social studies (studi sosial, Ilmu Pengetahuan Sosial (IPS. IPS merupakan pembelajaran pada tingkat sekolah yang berperan mengfungsionalkan ilmu-ilmu sosial yang bersifat teoritik dalam kehidupan nyata dalam masyarakat. Model pembelajaran CTL adalah model pembelajaran yang menuntut kreatifitas guru dalam mengaitkan subject matter dengan kehidupan nyata mahasiswa guna membantu mahasiswa untuk lebih mudah memaknai materi tersebut.

AdvancED Flex 4

CERN Document Server

Tiwari, Shashank; Schulze, Charlie

2010-01-01

AdvancED Flex 4 makes advanced Flex 4 concepts and techniques easy. Ajax, RIA, Web 2.0, mashups, mobile applications, the most sophisticated web tools, and the coolest interactive web applications are all covered with practical, visually oriented recipes. * Completely updated for the new tools in Flex 4* Demonstrates how to use Flex 4 to create robust and scalable enterprise-grade Rich Internet Applications.* Teaches you to build high-performance web applications with interactivity that really engages your users.* What you'll learn Practiced beginners and intermediate users of Flex, especially

Nonproliferation characteristics of advanced fuel cycle concepts

International Nuclear Information System (INIS)

Persiani, P.J.

1998-01-01

The purpose of this study is to comment on the proliferation characteristic profiles of some of the proposed fuel cycle alternatives to help ensure that nonproliferation concerns are introduced into the early stages of a fuel cycle concept development program, and to perhaps aid in the more effective implementation of the international nonproliferation regime initiatives and safeguards methods and systems. Alternative cycle concepts proposed by several countries involve the recycle of spent fuel without the separation of plutonium from uranium and fission products

Advanced composites structural concepts and materials technologies for primary aircraft structures: Design/manufacturing concept assessment

Science.gov (United States)

Chu, Robert L.; Bayha, Tom D.; Davis, HU; Ingram, J. ED; Shukla, Jay G.

1992-01-01

Composite Wing and Fuselage Structural Design/Manufacturing Concepts have been developed and evaluated. Trade studies were performed to determine how well the concepts satisfy the program goals of 25 percent cost savings, 40 percent weight savings with aircraft resizing, and 50 percent part count reduction as compared to the aluminum Lockheed L-1011 baseline. The concepts developed using emerging technologies such as large scale resin transfer molding (RTM), automatic tow placed (ATP), braiding, out-of-autoclave and automated manufacturing processes for both thermoset and thermoplastic materials were evaluated for possible application in the design concepts. Trade studies were used to determine which concepts carry into the detailed design development subtask.

Advanced payload concepts and system architecture for emerging services in Indian National Satellite Systems

Science.gov (United States)

Balasubramanian, E. P.; Rao, N. Prahlad; Sarkar, S.; Singh, D. K.

2008-07-01

Over the past two decades Indian Space Research Organization (ISRO) has developed and operationalized satellites to generate a large capacity of transponders for telecommunication service use in INSAT system. More powerful on-board transmitters are built to usher-in direct-to-home broadcast services. These have transformed the Satcom application scenario in the country. With the proliferation of satellite technology, a shift in the Indian market is witnessed today in terms of demand for new services like Broadband Internet, Interactive Multimedia, etc. While it is imperative to pay attention to market trends, ISRO is also committed towards taking the benefits of technological advancement to all round growth of our population, 70% of which dwell in rural areas. The initiatives already taken in space application related to telemedicine, tele-education and Village Resource Centres are required to be taken to a greater height of efficiency. These targets pose technological challenges to build a large capacity and cost-effective satellite system. This paper addresses advanced payload concepts and system architecture along with the trade-off analysis on design parameters in proposing a new generation satellite system capable of extending the reach of the Indian broadband structure to individual users, educational and medical institutions and enterprises for interactive services. This will be a strategic step in the evolution of INSAT system to employ advanced technology to touch every human face of our population.

Integral design concepts of advanced water cooled reactors. Proceedings of a technical committee meeting

International Nuclear Information System (INIS)

1997-11-01

Under the sub-programme on non-electrical applications of advanced reactors, the International Atomic Energy Agency has been providing a worldwide forum for exchange of information on integral reactor concepts. Two Technical Committee meetings were held in 1994 and 1995 on the subject where state-of-the-art developments were presented. Efforts are continuing for the development of advanced nuclear reactors of both evolutionary and innovative design, for electricity, co-generation and heat applications. While single purpose reactors for electricity generation may require small and medium sizes under certain conditions, reactors for heat applications and co-generation would be necessary in the small and medium range and need to be located closer to the load centres. The integral design approach to the development of advanced light water reactors has received special attention over the past few years. Several designs are in the detailed design stage, some are under construction, one prototype is in operation. A need has been felt for guidance on a number of issues, ranging from design objectives to the assessment methodology needed to show how integral designs can meet these objectives, and also to identify their advantages and problem areas. The technical document addresses the current status of the design, safety and operational issues of integral reactors and recommends areas for future development

CISH is induced during DC development and regulates DC-mediated CTL activation.

Science.gov (United States)

Miah, Mohammad Alam; Yoon, Cheol-Hee; Kim, Joonoh; Jang, Jinah; Seong, Young-Rim; Bae, Yong-Soo

2012-01-01

The cytokine inducible SH2-domain protein (CISH) is a well-known STAT5 target gene, but its role in the immune system remains uncertain. In this study, we found that CISH is predominantly induced during dendritic cell (DC) development from mouse bone marrow (BM) cells and plays a crucial role in type 1 DC development and DC-mediated CTL activation. CISH knockdown reduced the expression of MHC class I, co-stimulatory molecules and pro-inflammatory cytokines in BMDCs. Meanwhile, the DC yield was markedly enhanced by CISH knockdown via cell-cycle activation and reduction of cell apoptosis. Down-regulation of cell proliferation at the later stage of DC development was found to be associated with CISH-mediated negative feedback regulation of STAT5 activation. In T-cell immunity, OT-1 T-cell proliferation was significantly reduced by CISH knockdown in DCs, whereas OT-2 T-cell proliferation was not affected by CISH knockdown. CTLs generated by DC vaccination were also markedly reduced by CISH knockdown, followed by significant impairment of DC-based tumor immunotherapy. Taken together, our data suggest that CISH expression at the later stage of DC development triggers the shutdown of DC progenitor cell proliferation and facilitates DC differentiation into a potent stimulator of CTLs. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

NASA Advanced Explorations Systems: Concepts for Logistics to Living

Science.gov (United States)

Shull, Sarah A.; Howe, A. Scott; Flynn, Michael T.; Howard, Robert

2012-01-01

, Howard 2010]. Several of the L2L concepts that have shown the most potential in the past are based on NASA cargo transfer bags (CTBs) or their equivalents which are currently used to transfer cargo to and from the ISS. A high percentage of all logistics supplies are packaging mass and for a 6-month mission a crew of four might need over 100 CTBs. These CTBs are used for on-orbit transfer and storage but eventually becomes waste after use since down mass is very limited. The work being done in L2L also considering innovative interior habitat construction that integrate the CTBs into the walls of future habitats. The direct integration could provide multiple functions: launch packaging, stowage, radiation protection, water processing, life support augmentation, as well as structure. Reuse of these CTBs would reduce the amount of waste generated and also significantly reduce future up mass requirements for exploration missions. Also discussed here is the L2L water wall , an innovative reuse of an unfolded CTB as a passive water treatment system utilizing forward osmosis. The bags have been modified to have an inner membrane liner that allows them to purify wastewater. They may also provide a structural water-wall element that can be used to provide radiation protection and as a structural divider. Integration of the components into vehicle/habitat architecture and consideration of operations concepts and human factors will be discussed. In the future these bags could be designed to treat wastewater, concentrated brines, and solid wastes, and to dewater solid wastes and produce a bio-stabilized construction element. This paper will describe the follow-on work done in design, fabrication and demonstrations of various L2L concepts, including advanced CTBs for reuse/repurposing, internal outfitting studies and the CTB-based forward osmosis water wall.

Test Concept for Advanced Oxidation Techniques

DEFF Research Database (Denmark)

Bennedsen, Lars Rønn; Søgaard, Erik Gydesen; Mortensen, Lars

advanced on-site oxidation tests. The remediation techniques included are electrochemical oxidation, photochemical/photocatalytic oxidation, ozone, hydrogen peroxide, permanganate, and persulfate among others. A versatile construction of the mobile test unit makes it possible to combine different...

Knowledge gaps in economic analyses of advanced reactor concepts

International Nuclear Information System (INIS)

Moore, M.; Pencer, J.; Leung, L.K.H.; Sadhankar, R.

2014-01-01

The development of next generation nuclear systems is predicated on improvement in sustainability, safety, proliferation resistance and economics. The economic assessment of the reactor concept is required as early as in the concept development stage. The Generation IV International Forum (GIF) has developed a methodology for economic assessment of the Generation IV (GEN-IV) nuclear energy systems. The GIF economics methodology was used for the assessment of one of the reactor concepts for the Super-Critical Water-cooled Reactors (SCWR), namely the European pressure-vessel type concept referred to as the High Performance Light Water Reactor (HPLWR). The economic analysis involved studying the sensitivity of two main economic indicators, namely, the Levelized Unit Electricity Cost (LUEC) and the Total Capital Investment Cost (TCIC). The knowledge gaps in estimating the capital costs and fuel costs, as well as the uncertainties in other cost parameters affecting the economic assessment of the nuclear energy system in the concept development stage are presented. (author)

Integrated concept development of next-step helical-axis advanced stellarators

Energy Technology Data Exchange (ETDEWEB)

Warmer, Felix

2016-04-13

With the increasing energy demand of mankind and the transformation of our society towards sustainability, nuclear fusion by magnetic confinement is a promising option for the sustainable electricity supply in the future. In view of these prospects this thesis focuses on the concept development of next-step helical-axis advanced stellarator (HELIAS) burning-plasma devices. The HELIAS-line is the continued development of the prototype optimised stellarator Wendelstein 7-X which started operation in 2015. For the integrated concept development of such devices, the approach taken in this work encompasses detailed physics and engineering considerations while also including economic aspects. Starting with physics considerations, the properties of plasma transport and confinement of 3D stellarator configurations are discussed due to their critical importance for the device design. It becomes clear that current empirical confinement time scalings are not sufficient to predict the confinement in future stellarator devices. Therefore, detailed 1D transport simulations are carried out to reduce the uncertainties regarding confinement. Beyond the well-validated neoclassical approach, first attempts are made to include results from state-of-the-art turbulence simulations into the 1D transport simulations to further enhance the predictive capabilities. Next, for the systematic development of consistent design points, stellarator-specific models are developed and implemented in the well-established European systems code PROCESS. This allows a consistent description of an entire HELIAS fusion power plant including physics, engineering, and economic considerations. With the confidence obtained from a verification study, systems studies are for the first time applied for a HELIAS power-plant which shows that the available design window is constrained by the beta-limit. Furthermore, an economic comparison of an exemplary design point to an ''equivalent'' tokamak

Organization of the 16th Advanced Accelerator Concepts (AAC) Workshop by Stanford University

Energy Technology Data Exchange (ETDEWEB)

Huang, Zhirong [Stanford Univ., CA (United States); Hogan, Mark [Stanford Univ., CA (United States)

2015-09-30

Essentially all we know today and will learn in the future about the fundamental nature of matter is derived from probing it with directed beams of particles such as electrons, protons, neutrons, heavy ions, and photons. The resulting ability to “see” the building blocks of matter has had an immense impact on society and our standard of living. Over the last century, particle accelerators have changed the way we look at nature and the universe we live in and have become an integral part of the Nation’s technical infrastructure. Today, particle accelerators are essential tools of modern science and technology. The cost and capabilities of accelerators would be greatly enhanced by breakthroughs in acceleration methods and technology. For the last 32 years, the Advanced Accelerator Concepts (AAC) Workshop has acted as the focal point for discussion and development of the most promising acceleration physics and technology. It is a particularly effective forum where the discussion is leveraged and promoted by the unique and demanding feature of the AAC Workshop: the working group structure, in which participants are asked to consider their contributions in terms of even larger problems to be solved. The 16th Advanced Accelerator Concepts (AAC2014) Workshop was organized by Stanford University from July 13 - 18, 2014 at the Dolce Hays Mansion in San Jose, California. The conference had a record 282 attendees including 62 students. Attendees came from 11 countries representing 66 different institutions. The workshop format consisted of plenary sessions in the morning with topical leaders from around the world presenting the latest breakthroughs to the entire workshop. In the late morning and afternoons attendees broke out into eight different working groups for more detailed presentations and discussions that were summarized on the final day of the workshop. In addition, there were student tutorial presentations on two afternoons to provide in depth education and

To MARS and Beyond with Nuclear Power - Design Concept of Korea Advanced Nuclear Thermal Engine Rocket

Energy Technology Data Exchange (ETDEWEB)

Nam, Seung Hyun; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

2013-05-15

The President Park of ROK has also expressed support for space program promotion, praising the success of NARO as evidence of a positive outlook. These events hint a strong signal that ROK's space program will be accelerated by the national eager desire. In this national eager desire for space program, the policymakers and the aerospace engineers need to pay attention to the advanced nuclear technology of ROK that is set to a major world nuclear energy country, even exporting the technology. The space nuclear application is a very much attractive option because its energy density is the most enormous among available energy sources in space. This paper presents the design concept of Korea Advanced Nuclear Thermal Engine Rocket (KANuTER) that is one of the advanced nuclear thermal rocket engine developing in Korea Advanced Institute of Science and Technology (KAIST) for space application. Solar system exploration relying on CRs suffers from long trip time and high cost. In this regard, nuclear propulsion is a very attractive option for that because of higher performance and already demonstrated technology. Although ROK was a late entrant into elite global space club, its prospect as a space racer is very bright because of the national eager desire and its advanced technology. Especially it is greatly meaningful that ROK has potential capability to launch its nuclear technology into space as a global nuclear energy leader and a soaring space adventurer. In this regard, KANuTER will be a kind of bridgehead for Korean space nuclear application.

To MARS and Beyond with Nuclear Power - Design Concept of Korea Advanced Nuclear Thermal Engine Rocket

International Nuclear Information System (INIS)

Nam, Seung Hyun; Chang, Soon Heung

2013-01-01

The President Park of ROK has also expressed support for space program promotion, praising the success of NARO as evidence of a positive outlook. These events hint a strong signal that ROK's space program will be accelerated by the national eager desire. In this national eager desire for space program, the policymakers and the aerospace engineers need to pay attention to the advanced nuclear technology of ROK that is set to a major world nuclear energy country, even exporting the technology. The space nuclear application is a very much attractive option because its energy density is the most enormous among available energy sources in space. This paper presents the design concept of Korea Advanced Nuclear Thermal Engine Rocket (KANuTER) that is one of the advanced nuclear thermal rocket engine developing in Korea Advanced Institute of Science and Technology (KAIST) for space application. Solar system exploration relying on CRs suffers from long trip time and high cost. In this regard, nuclear propulsion is a very attractive option for that because of higher performance and already demonstrated technology. Although ROK was a late entrant into elite global space club, its prospect as a space racer is very bright because of the national eager desire and its advanced technology. Especially it is greatly meaningful that ROK has potential capability to launch its nuclear technology into space as a global nuclear energy leader and a soaring space adventurer. In this regard, KANuTER will be a kind of bridgehead for Korean space nuclear application

Needs of Advanced Safeguards Technologies for Future Nuclear Fuel Cycle (FNFC) Facilities and a Trial Application of SBD Concept to Facility Design of a Hypothetical FNFC Facility

International Nuclear Information System (INIS)

Seya, M.; Hajima, R.; Nishimori, N.; Hayakawa, T.; Kikuzawa, N.; Shizuma, T.; Fujiwara, M.

2010-01-01

Some of future nuclear fuel cycle (FNFC) facilities are supposed to have the characteristic features of very large throughput of plutonium, low decontamination reprocessing (no purification process; existence of certain amount of fission products (FP) in all process material), full minor actinides (MA) recycle, and treatment of MOX with FP and MA in fuel fabrication. In addition, the following international safeguards requirements have to be taken into account for safeguards approaches of the FNFC facilities. -Application of integrated safeguards (IS) approach; -Remote (unattended) verification; - 'Safeguards by Design' (SBD) concept. These features and requirements compel us to develop advanced technologies, which are not emerged yet. In order to realize the SBD, facility designers have to know important parts of design information on advanced safeguards systems before starting the facility design. The SBD concept requires not only early start of R and D of advanced safeguards technologies (before starting preliminary design of the facility) but also interaction steps between researchers working on safeguards systems and nuclear facility designers. The interaction steps are follows. Step-1; researchers show images of advanced safeguards systems to facility designers based on their research. Step-2; facility designers take important design information on safeguards systems into process systems of demonstration (or test) facility. Step-3; demonstration and improvement of both systems based on the conceptual design. Step-4; Construction of a FNFC facility with the advanced safeguards systems We present a trial application of the SBD concept to a hypothetical FNFC facility with an advanced hybrid K-edge densitometer and a Pu NDA system for spent nuclear fuel assembly using laser Compton scattering (LCS) X-rays and γ-rays and other advanced safeguards systems. (author)

Therapy of established B16-F10 melanoma tumors by a single vaccination of CTL/T helper peptides in VacciMax®

Directory of Open Access Journals (Sweden)

Korets-Smith Ella

2007-04-01

Full Text Available Abstract Background Melanoma tumors are known to express antigens that usually induce weak immune responses of short duration. Expression of both tumor-associated antigens p53 and TRP2 by melanoma cells raises the possibility of simultaneously targeting more than one antigen in a therapeutic vaccine. In this report, we show that VacciMax® (VM, a novel liposome-based vaccine delivery platform, can increase the immunogenicity of melanoma associated antigens, resulting in tumor elimination. Methods C57BL/6 mice bearing B16-F10 melanoma tumors were vaccinated subcutaneously 6 days post tumor implantation with a mixture of synthetic peptides (modified p53: 232–240, TRP-2: 181–188 and PADRE and CpG. Tumor growth was monitored and antigen-specific splenocyte responses were assayed by ELISPOT. Results Vaccine formulated in VM increased the number of both TRP2- and p53-specific IFN-γ producing splenocytes following a single vaccination. Vaccine formulated without VM resulted only in enhanced IFN-γ producing splenocytes to one CTL epitopes (TRP2:180–188, suggesting that VM overcomes antigen dominance and enhances immunogenicity of multiple epitopes. Vaccination of mice bearing 6-day old B16-F10 tumors with both TRP2 and p53-peptides formulated in VM successfully eradicated tumors in all mice. A control vaccine which contained all ingredients except liposomes resulted in eradication of tumors in no more than 20% of mice. Conclusion A single administration of VM is capable of inducing an effective CTL response to multiple tumor-associated antigens. The responses generated were able to reject 6-day old B16-F10 tumors.

The effect of application of contextual teaching and learning (CTL model-based on lesson study with mind mapping media to assess student learning outcomes on chemistry on colloid systems

Directory of Open Access Journals (Sweden)

Annisa Fadillah

2017-08-01

Full Text Available The research was conducted to determine the effect of the application of CTL learning model based on lesson study with mind mapping media to the learning outcomes of students on colloid systems. The population of this research was all students of grade XI of SMA N 1 Sunggal. The sample was taken using on the purposive random sampling. The Experiment class was taught with Contextual Teaching and Learning (CTL model based on Lesson Study with Mind Mapping media and the control class taught with conventional learning model. The data was collected using an objective test was consisting of 20 questions which validity, reliability, level of difficulty and power of difference had been tested. T test results showed that tcalculate = 2.1 and ttable = 1.6697 thus tcalculate> ttable which means that Ha is accepted and Ho is rejected. The enhancement of the student learning outcomes showed that the results of experiment class are g = 72.88%, while the control class is 68.97%. From the percentage, it can be seen that learning outcomes of the experiment class are greater than the control class. The analysis of developing cognitive aspects pointed out that C1 = 70.02%, C2 = 73.58%, C3 = 68.63%, Thus the domain of cognitive level are on the cognitive aspects of C2. The result of Lesson Study Analysis showed the results of 71.09% at the first lesson and 88.28% at the second lesson. It means that there is increasing adherence to the indicators after two lessons. Based on the above results, it can be concluded that the result of studying chemistry of the students of class XI of SMA Negeri I Sunggal TA 2014/2015 taught by a CTL model based  on Lesson Study with Mind Mapping media was higher (72.88% than those taught by conventional learning models (68.97% in the subject matter of colloids System.

Environmentally Responsible Aviation (ERA) Project - N+2 Advanced Vehicle Concepts Study and Conceptual Design of Subscale Test Vehicle (STV) Final Report

Science.gov (United States)

Bonet, John T.; Schellenger, Harvey G.; Rawdon, Blaine K.; Elmer, Kevin R.; Wakayama, Sean R.; Brown, Derrell L.; Guo, Yueping

2011-01-01

NASA has set demanding goals for technology developments to meet national needs to improve fuel efficiency concurrent with improving the environment to enable air transportation growth. A figure shows NASA's subsonic transport system metrics. The results of Boeing ERA N+2 Advanced Vehicle Concept Study show that the Blended Wing Body (BWB) vehicle, with ultra high bypass propulsion systems have the potential to meet the combined NASA ERA N+2 goals. This study had 3 main activities. 1) The development of an advanced vehicle concepts that can meet the NASA system level metrics. 2) Identification of key enabling technologies and the development of technology roadmaps and maturation plans. 3) The development of a subscale test vehicle that can demonstrate and mature the key enabling technologies needed to meet the NASA system level metrics. Technology maturation plans are presented and include key performance parameters and technical performance measures. The plans describe the risks that will be reduced with technology development and the expected progression of technical maturity.

Civic consciousness: A viable concept for advancing students’ ability to orient themselves to possible futures?

Directory of Open Access Journals (Sweden)

Johan Sandahl

2015-01-01

Full Text Available In history didactics the concept of historical consciousness has become an important theoretical framework in developing a meaningful history education. One significant aspect of historical consciousness is to give students a “usable past” to orient to possible futures. Previous research has shown that history is important when students think about the future but that their use of history in meaning-making is simplistic and based on present-day-thinking. Much research has focused on advancing students’ ability to use history in orientation to possible futures, but less attention has been focused on contemporary studies and its role in the process of orientation. By introducing a tentative concept, civic consciousness, the issue of students’ orientation is explored by studying students’ perspectives on democracy in past-present-future. The data consists of 142 narratives and reveals a pattern of normative stances, process orientation and action orientation. These aspects are considered to be important components of civic consciousness and these have implications for how social studies educators should address the challenges of preparing students for the future.

Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors

DEFF Research Database (Denmark)

Andersen, Rikke Sick; Sørensen, Rikke Bæk; Ritter, Cathrin

2011-01-01

. Furthermore, blood from cancer patients and healthy donors was screened for spontaneous T-cell reactivity against the peptide in IFN-γ ELISPOT assays. Patients with breast cancer, malignant melanoma, or renal cell carcinoma hosted powerful and high-frequency T-cell responses against the peptide. In addition......, when blood from healthy donors was tested, similar responses were observed. Ultimately, serum from cancer patients and healthy donors was analyzed for anti-cyclin B1 antibodies. Humoral responses against cyclin B1 were frequently detected in both cancer patients and healthy donors. In conclusion......, a high-affinity cyclin B1-derived HLA-A2-restricted CTL epitope was identified, which was presented on the cell surface of cancer cells, and elicited spontaneous T-cell responses in cancer patients and healthy donors....

Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors

DEFF Research Database (Denmark)

Andersen, Rikke Sick; Sørensen, Rikke Bæk; Ritter, Cathrin

2011-01-01

. Furthermore, blood from cancer patients and healthy donors was screened for spontaneous T-cell reactivity against the peptide in IFN-¿ ELISPOT assays. Patients with breast cancer, malignant melanoma, or renal cell carcinoma hosted powerful and high-frequency T-cell responses against the peptide. In addition......, when blood from healthy donors was tested, similar responses were observed. Ultimately, serum from cancer patients and healthy donors was analyzed for anti-cyclin B1 antibodies. Humoral responses against cyclin B1 were frequently detected in both cancer patients and healthy donors. In conclusion......, a high-affinity cyclin B1-derived HLA-A2-restricted CTL epitope was identified, which was presented on the cell surface of cancer cells, and elicited spontaneous T-cell responses in cancer patients and healthy donors....

Contextual Teaching and Learning Approach of Mathematics in Primary Schools

Science.gov (United States)

Selvianiresa, D.; Prabawanto, S.

2017-09-01

The Contextual Teaching and Learning (CTL) approach is an approach involving active students in the learning process to discover the concepts learned through to knowledge and experience of the students. Similar to Piaget’s opinion that learning gives students an actives trying to do new things by relating their experiences and building their own minds. When students to connecting mathematics with real life, then students can looking between a conceptual to be learned with a concept that has been studied. So that, students can developing of mathematical connection ability. This research is quasi experiment with a primary school in the city of Kuningan. The result showed that CTL learning can be successful, when learning used a collaborative interaction with students, a high level of activity in the lesson, a connection to real-world contexts, and an integration of science content with other content and skill areas. Therefore, CTL learning can be applied by techer to mathematics learning in primary schools.

The advanced MAPLE reactor concept

International Nuclear Information System (INIS)

Lidstone, R.F.; Lee, A.G.; Gillespie, G.E.; Smith, H.J.

1989-01-01

During the past several years, Atomic Energy of Canada Limited (AECL) has been developing the new MAPLE multipurpose reactor concept, which is capable of generating peak thermal neutron fluxes of up to 3 x 10 18 n/m 2 s in its heavy water reflector at a nominal thermal power level of 15MW. An assessment of the MAPLE-D 2 O reactor has shown that it could also be used as a high-flux neutron source. it could be developed to be used for several applications if a 12-site annular core is used. Thermal fluxes several times greater than in existing facilities would be available (author)

Advances in architectural concepts to support distributed systems design

NARCIS (Netherlands)

Ferreira Pires, Luis; Vissers, C.A.; van Sinderen, Marten J.

1993-01-01

This paper presents and discusses some architectural concepts for distributed systems design. These concepts are derived from an analysis of limitations of some currently available standard design languages. We conclude that language design should be based upon the careful consideration of

Advances and Evolving Concepts in Allergic Asthma.

Science.gov (United States)

Tung, Hui-Ying; Li, Evan; Landers, Cameron; Nguyen, An; Kheradmand, Farrah; Knight, J Morgan; Corry, David B

2018-02-01

Allergic asthma is a heterogeneous disorder that defies a unanimously acceptable definition, but is generally recognized through its highly characteristic clinical expression of dyspnea and cough accompanied by clinical data that document reversible or exaggerated airway constriction and obstruction. The generally rising prevalence of asthma in highly industrialized societies despite significant therapeutic advances suggests that the fundamental cause(s) of asthma remain poorly understood. Detailed analyses of both the indoor (built) and outdoor environments continue to support the concept that not only inhaled particulates, especially carbon-based particulate pollution, pollens, and fungal elements, but also many noxious gases and chemicals, especially biologically derived byproducts such as proteinases, are essential to asthma pathogenesis. Phthalates, another common class of chemical pollutant found in the built environment, are emerging as potentially important mediators or attenuators of asthma. Other biological products such as endotoxin have also been confirmed to be protective in both the indoor and outdoor contexts. Proasthmatic factors are believed to activate, and in some instances initiate, pathologic inflammatory cascades through complex interactions with pattern recognition receptors (PRRs) expressed on many cell types, but especially airway epithelial cells. PRRs initiate the release of proallergic cytokines such as interleukin (IL)-33, IL-25, and others that coordinate activation of innate lymphoid cells type 2 (ILC2), T helper type 2 cells, and immunoglobulin E-secreting B cells that together promote additional inflammation and the major airway remodeling events (airway hyperresponsiveness, mucus hypersecretion) that promote airway obstruction. Proteinases, with airway fungi and viruses being potentially important sources, are emerging as critically important initiators of these inflammatory cascades in part through their effects on clotting

Refinement of the concept of uncertainty.

Science.gov (United States)

Penrod, J

2001-04-01

To analyse the conceptual maturity of uncertainty; to develop an expanded theoretical definition of uncertainty; to advance the concept using methods of concept refinement; and to analyse congruency with the conceptualization of uncertainty presented in the theory of hope, enduring, and suffering. Uncertainty is of concern in nursing as people experience complex life events surrounding health. In an earlier nursing study that linked the concepts of hope, enduring, and suffering into a single theoretical scheme, a state best described as 'uncertainty' arose. This study was undertaken to explore how this conceptualization fit with the scientific literature on uncertainty and to refine the concept. Initially, a concept analysis using advanced methods described by Morse, Hupcey, Mitcham and colleagues was completed. The concept was determined to be partially mature. A theoretical definition was derived and techniques of concept refinement using the literature as data were applied. The refined concept was found to be congruent with the concept of uncertainty that had emerged in the model of hope, enduring and suffering. Further investigation is needed to explore the extent of probabilistic reasoning and the effects of confidence and control on feelings of uncertainty and certainty.

Space Mission Concept Development Using Concept Maturity Levels

Science.gov (United States)

Wessen, Randii R.; Borden, Chester; Ziemer, John; Kwok, Johnny

2013-01-01

Over the past five years, pre-project formulation experts at the Jet Propulsion Laboratory (JPL) has developed and implemented a method for measuring and communicating the maturity of space mission concepts. Mission concept development teams use this method, and associated tools, prior to concepts entering their Formulation Phases (Phase A/B). The organizing structure is Concept Maturity Level (CML), which is a classification system for characterizing the various levels of a concept's maturity. The key strength of CMLs is the ability to evolve mission concepts guided by an incremental set of assessment needs. The CML definitions have been expanded into a matrix form to identify the breadth and depth of analysis needed for a concept to reach a specific level of maturity. This matrix enables improved assessment and communication by addressing the fundamental dimensions (e.g., science objectives, mission design, technical risk, project organization, cost, export compliance, etc.) associated with mission concept evolution. JPL's collaborative engineering, dedicated concept development, and proposal teams all use these and other CML-appropriate design tools to advance their mission concept designs. This paper focuses on mission concept's early Pre-Phase A represented by CMLs 1- 4. The scope was limited due to the fact that CMLs 5 and 6 are already well defined based on the requirements documented in specific Announcement of Opportunities (AO) and Concept Study Report (CSR) guidelines, respectively, for competitive missions; and by NASA's Procedural Requirements NPR 7120.5E document for Projects in their Formulation Phase.

Chemokines: a new dendritic cell signal for T cell activation

Directory of Open Access Journals (Sweden)

Christoph A Thaiss

2011-08-01

Full Text Available Dendritic cells (DCs are the main inducers and regulators of cytotoxic T lymphocyte (CTL responses against viruses and tumors. One checkpoint to avoid misguided CTL activation, which might damage healthy cells of the body, is the necessity for multiple activation signals, involving both antigenic as well as additional signals that reflect the presence of pathogens. DCs provide both signals when activated by ligands of pattern recognition receptors and licensed by helper lymphocytes. Recently, it has been established that such T cell licensing can be facilitated by CD4+ T helper cells (classical licensing or by NKT cells (alternative licensing. Licensing regulates the DC/CTL cross-talk at multiple layers. Direct recruitment of CTLs through chemokines released by licensed DCs has recently emerged as a common theme and has a crucial impact on the efficiency of CTL responses. Here, we discuss recent advances in our understanding of DC licensing for cross-priming and implications for the temporal and spatial regulation underlying this process. Future vaccination strategies will benefit from a deeper insight into the mechanisms that govern CTL activation.

Innovative concepts for marginal fields (advanced monotower developments)

International Nuclear Information System (INIS)

Smith, M.T.; Marks, V.E.

1995-01-01

The braced monotower provides a safe, functional and cost effective solution for topsides up to 500 tonnes, with up to 8 wells and standing in water depths of up to 70 meters. It is both simple in concept and structurally efficient. The superstructure is supported by a single column which is stayed by three symmetrically orientated legs. A broad mudline base is also provided to limit pile loads. The final concept offers complete protection to the risers and conductors from ship impact, as all appurtenances are housed within the central column. The basic design philosophy of the low intervention platform is to minimize the onboard equipment to that vitally needed to produce hydrocarbon. The concept eliminates the life support functions that on a normal North Sea platform can contribute up to 50% of the topside dry weight. A system of Zero Based Engineering is used that ensures each item of equipment contributes more to the NPV of the platform than the fully built-up through life cost. This effectively eliminates the operator preference factor and the ''culture'' cost

AICD -- Advanced Industrial Concepts Division Biological and Chemical Technologies Research Program. 1993 Annual summary report

Energy Technology Data Exchange (ETDEWEB)

Petersen, G.; Bair, K.; Ross, J. [eds.

1994-03-01

The annual summary report presents the fiscal year (FY) 1993 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1993 (ASR 93) contains the following: A program description (including BCTR program mission statement, historical background, relevance, goals and objectives), program structure and organization, selected technical and programmatic highlights for 1993, detailed descriptions of individual projects, a listing of program output, including a bibliography of published work, patents, and awards arising from work supported by BCTR.

Advancing the expectancy concept via the interplay between theory and research.

Science.gov (United States)

Del Boca, Frances K; Darkes, Jack; Goldman, Mark S; Smith, Gregory T

2002-06-01

Four papers from a 2001 Research Society on Alcoholism symposium on expectancy theory and research are summarized. The symposium contributors describe recent advances in expectancy theory and discuss their implications for assessment and for understanding the processes of development and change in the behavioral domain of alcohol use. First, findings are integrated across the diverse domains in which the expectancy concept has been applied. Second, the implications of expectancy theory for the measurement of expectancy structure and process are examined. Third, research and theory regarding alcohol expectancy development and change are presented, with an emphasis on the role of expectancies as mediators of known antecedents of drinking. Finally, an experimental procedure for investigating the causal role of expectancies is described, together with its implications for theory testing and prevention or intervention programming. Collectively, the symposium contributions demonstrate the utility of an integrated expectancy theory for the generation of innovative research operations and new insights regarding behavior development and change. Consistent with the notion of consilience, expectancy theory has demonstrated a convergence of findings across different levels of analysis, as well as across different operations, methods, and research designs.

The advanced thermionics initiative...program update

International Nuclear Information System (INIS)

Lamp, T.R.; Donovan, B.D.

1993-01-01

The United States Air Force has had a long standing interest in thermionic space power dating back to the early 1960s when a heat pipe cooled thermionic converter was demonstrated through work at the predecessor to Wright Laboratory (WL). With the exception of the short hiatus in the mid-70s, Air Force thermionics work at Wright Laboratory has continued to the present time with thermionic technology programs including the burst power thermionic phase change concepts, heat pipe cooled planar diodes, and advanced in-core concept developments such as composite materials, insulators and oxygenation. The Advanced Thermionics Initiative (ATI) program was organized to integrate thermionic technology advances into a converter suitable for in-core reactor applications in the 10 to 40 kWe power range. As an advanced thermionics technology program, the charter and philosophy of the ATI program is to provide the needed advanced converter concepts in support of national thermionic space power programs

Equipment concept design and development plans for microgravity science and applications research on space station: Combustion tunnel, laser diagnostic system, advanced modular furnace, integrated electronics laboratory

Science.gov (United States)

Uhran, M. L.; Youngblood, W. W.; Georgekutty, T.; Fiske, M. R.; Wear, W. O.

1986-01-01

Taking advantage of the microgravity environment of space NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. Previous studies have been performed to define from the researcher's perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. Functional requirements for the identified experimental apparatus and support equipment were determined. From these hardware requirements, several items were selected for concept designs and subsequent formulation of development plans. This report documents the concept designs and development plans for two items of experiment apparatus - the Combustion Tunnel and the Advanced Modular Furnace, and two items of support equipment the Laser Diagnostic System and the Integrated Electronics Laboratory. For each concept design, key technology developments were identified that are required to enable or enhance the development of the respective hardware.

Advanced Concepts. Chapter 21

Science.gov (United States)

Johnson, Les; Mulqueen, Jack

2013-01-01

Before there is a funded space mission, there must be a present need for the mission. Space science and exploration are expensive, and without a well-defined and justifiable need, no one is going to commit significant funding for any space endeavor. However, as discussed in Chapter 1, applications of space technology and many and broad, hence there are many ways to determine and establish a mission need. Robotic science missions are justified by their science return. To be selected for flight, questions like these must be addressed: What is the science question that needs answering, and will the proposed mission be the most cost-effective way to answer it? Why does answering the question require an expensive space flight, instead of some ground-based alternative? If the question can only be answered by flying in space, then why is this approach better than other potential approaches? How much will it cost? And is the technology required to answer the question in hand and ready to use? If not, then how much will it cost and how long will it take to mature the technology to a usable level? There are also many ways to justify human exploration missions, including science return, technology advancement, as well as intangible reasons, such as national pride. Nonetheless, many of the questions that need answering, are similar to those for robotic science missions: Where are the people going, why, and will the proposed mission be the most cost-effective way to get there? What is the safest method to achieve the goal? How much will it cost? And is the technology required to get there and keep the crew alive in hand and ready to use? If not, then how much will it cost and how long will it take to mature the technology to a usable level? Another reason for some groups sending spacecraft into space is for profit. Telecommunications, geospatial imaging, and tourism are examples of proven, market-driven space missions and applications. For this specific set of users, the

Advanced PWR fuel design concepts

International Nuclear Information System (INIS)

Andersor, C.K.; Harris, R.P.; Crump, M.W.; Fuhrman, N.

1987-01-01

For nearly 15 years, Combustion Engineering has provided pressurized water reactor fuel with the features most suppliers are now introducing in their advanced fuel designs. Zircaloy grids, removable upper end fittings, large fission gas plenum, high burnup, integral burnable poisons and sophisticated analytical methods are all features of C-E standard fuel which have been well proven by reactor performance. C-E's next generation fuel for pressurized water reactors features 24-month operating cycles, optimal lattice burnable poisons, increased resistance to common industry fuel rod failure mechanisms, and hardware and methodology for operating margin improvements. Application of these various improvements offer continued improvement in fuel cycle economics, plant operation and maintenance. (author)

Advanced Concept Exploration for Fast Ignition Science Program, Final Report

Energy Technology Data Exchange (ETDEWEB)

Stephens, Richard Burnite [General Atomics; McLean, Harry M. [Lawrence Livermore National Laboratory; Theobald, Wolfgang [Laboratory for Laser Energetics; Akli, Kramer U. [The Ohio State University; Beg, Farhat N. [University of California, San Diego; Sentoku, Yasuhiko [University of Nevada, Reno; Schumacher, Douglass W. [The Ohio State University; Wei, Mingsheng [General Atomics

2013-09-04

The Fast Ignition (FI) Concept for Inertial Confinement Fusion (ICF) has the potential to provide a significant advance in the technical attractiveness of Inertial Fusion Energy reactors. FI differs from conventional “central hot spot” (CHS) target ignition by decoupling compression from heating: using a laser (or heavy ion beam or Z pinch) drive pulse (10’s of nanoseconds) to create a dense fuel and a second, much shorter (~10 picoseconds) high intensity pulse to ignite a small volume within the dense fuel. The physics of fast ignition process was the focus of our Advanced Concept Exploration (ACE) program. Ignition depends critically on two major issues involving Relativistic High Energy Density (RHED) physics: The laser-induced creation of fast electrons and their propagation in high-density plasmas. Our program has developed new experimental platforms, diagnostic packages, computer modeling analyses, and taken advantage of the increasing energy available at laser facilities to advance understanding of the fundamental physics underlying these issues. Our program had three thrust areas: • Understand the production and characteristics of fast electrons resulting from FI relevant laser-plasma interactions and their dependence on laser prepulse and laser pulse length. • Investigate the subsequent fast electron transport in solid and through hot (FI-relevant) plasmas. • Conduct and understand integrated core-heating experiments by comparison to simulations. Over the whole period of this project (three years for this contract), we have greatly advanced our fundamental understanding of the underlying properties in all three areas: • Comprehensive studies on fast electron source characteristics have shown that they are controlled by the laser intensity distribution and the topology and plasma density gradient. Laser pre-pulse induced pre-plasma in front of a solid surface results in increased stand-off distances from the electron origin to the high density

The dynomak: An advanced spheromak reactor concept with imposed-dynamo current drive and next-generation nuclear power technologies

Energy Technology Data Exchange (ETDEWEB)

Sutherland, D.A., E-mail: das1990@uw.edu; Jarboe, T.R.; Morgan, K.D.; Pfaff, M.; Lavine, E.S.; Kamikawa, Y.; Hughes, M.; Andrist, P.; Marklin, G.; Nelson, B.A.

2014-04-15

A high-β spheromak reactor concept has been formulated with an estimated overnight capital cost that is competitive with conventional power sources. This reactor concept utilizes recently discovered imposed-dynamo current drive (IDCD) and a molten salt (FLiBe) blanket system for first wall cooling, neutron moderation and tritium breeding. Currently available materials and ITER-developed cryogenic pumping systems were implemented in this concept from the basis of technological feasibility. A tritium breeding ratio (TBR) of greater than 1.1 has been calculated using a Monte Carlo N-Particle (MCNP5) neutron transport simulation. High temperature superconducting tapes (YBCO) were used for the equilibrium coil set, substantially reducing the recirculating power fraction when compared to previous spheromak reactor studies. Using zirconium hydride for neutron shielding, a limiting equilibrium coil lifetime of at least thirty full-power years has been achieved. The primary FLiBe loop was coupled to a supercritical carbon dioxide Brayton cycle due to attractive economics and high thermal efficiencies. With these advancements, an electrical output of 1000 MW from a thermal output of 2486 MW was achieved, yielding an overall plant efficiency of approximately 40%.

PEMBELAJARAN PENJUMLAHAN BILANGAN PECAHAN DENGAN METODE CONTEXTUAL TEACHING AND LEARNING (CTL DI SD MUHAMMADIYAH PROGRAM KHUSUS, KOTA BARAT, SURAKARTA

Directory of Open Access Journals (Sweden)

Yulia Maftuhah Hidayati

2015-07-01

Full Text Available This study is aimed to describe the lesson plan, teaching learning process of sum of fractions based of Contextual Teaching and Learning (CTL, and the motivation of learners attend classes in learning. This study used a qualitative approach. The type of research is a case study. Validation of data is done through triangulation. Data were collected through interviews, observation, documentation, and testing. The technique of data analysis is descriptive, entrepretative. The results of this study indicate that (1 the development of lesson plan has been implemented routinely in every new school year, (2 the process of learning mathematics goes through three stages, namely preinstructional phase (preliminary / initial activity, instructional phase (core activities, and appraisal, (3 during the learning process, the students have a high motivation to participate in activities  because of the method used by teachers is fun and enjoyable

Advanced direct liquefaction concepts for PETC generic units. Quarterly technical progress report, January--March 1992

Energy Technology Data Exchange (ETDEWEB)

1992-04-01

In the Advance Coal Liquefaction Concept Proposal (ACLCP) carbon monoxide (CO) and water have been proposed as the primary reagents in the pretreatment process. The main objective of this project is to develop a methodology for pretreating coal under mild conditions based on a combination of existing processes which have shown great promise in liquefaction, extraction and pyrolysis studies. The aim of this pretreatment process is to partially depolymerise the coal, eliminate oxygen and diminish the propensity for retograde reactions during subsequent liquefaction. The desirable outcome of the CO pretreatment step should be: (1) enhanced liquefaction activity and/or selectivity toward products of higher quality due to chemical modification of the coal structure; (2) cleaner downstream products; (3) overall improvement in operability and process economics.

Advanced steam power plant concepts with optimized life-cycle costs: A new approach for maximum customer benefit

Energy Technology Data Exchange (ETDEWEB)

Seiter, C.

1998-07-01

The use of coal power generation applications is currently enjoying a renaissance. New highly efficient and cost-effective plant concepts together with environmental protection technologies are the main factors in this development. In addition, coal is available on the world market at attractive prices and in many places it is more readily available than gas. At the economical leading edge, standard power plant concepts have been developed to meet the requirements of emerging power markets. These concepts incorporate the high technological state-of-the-art and are designed to achieve lowest life-cycle costs. Low capital cost, fuel costs and operating costs in combination with shortest lead times are the main assets that make these plants attractive especially for IPPs and Developers. Other aspects of these comprehensive concepts include turnkey construction and the willingness to participate in BOO/BOT projects. One of the various examples of such a concept, the 2 x 610-MW Paiton Private Power Project Phase II in Indonesia, is described in this paper. At the technological leading edge, Siemens has always made a major contribution and was pacemaker for new developments in steam power plant technology. Modern coal-fired steam power plants use computer-optimized process and plant design as well as advanced materials, and achieve efficiencies exceeding 45%. One excellent example of this high technology is the world's largest lignite-fired steam power plant Schwarze Pumpe in Germany, which is equipped with two 800 MW Siemens steam turbine generators with supercritical steam parameters. The world's largest 50-Hz single-shaft turbine generator with supercritical steam parameters rated at 1025 MW for the Niederaussem lignite-fired steam power plant in Germany is a further example of the sophisticated Siemens steam turbine technology and sets a new benchmark in this field.

Advanced Interval Management (IM) Concepts of Operations

Science.gov (United States)

Barmore, Bryan E.; Ahmad, Nash'at N.; Underwood, Matthew C.

2014-01-01

This document provides a high-level description of several advanced IM operations that NASA is considering for future research and development. It covers two versions of IM-CSPO and IM with Wake Mitigation. These are preliminary descriptions to support an initial benefits analysis

Advanced teleoperation in nuclear applications

International Nuclear Information System (INIS)

Hamel, W.R.; Feldman, M.J.; Martin, H.L.

1984-01-01

A new generation of integrated remote maintenance systems is being developed to meet the needs of future nuclear fuel reprocessing at the Oak Ridge National Laboratory. Development activities cover all aspects of an advanced teleoperated maintenance system with particular emphasis on a new force-reflecting servomanipulator concept. The new manipulator, called the advanced servomanipulator, is microprocessor controlled and is designed to achieve force-reflection performance near that of mechanical master/slave manipulators. The advanced servomanipulator uses a gear-drive transmission which permits modularization for remote maintainability (by other advanced servomanipulators) and increases reliability. Human factors analysis has been used to develop an improved man/machine interface concept based upon colorgraphic displays and menu-driven tough screens. Initial test and evaluation of two advanced servomanipulator slave arms and several other development components have begun. 9 references, 5 figures

Advanced concepts in multi-dimensional radiation detection and imaging

International Nuclear Information System (INIS)

Vetter, Kai; Barnowski, Ross; Pavlovsky, Ryan; Haefner, Andy; Torii, Tatsuo; Shikaze, Yoshiaki; Sanada, Yukihisa

2016-01-01

Recent developments in the detector fabrication, signal readout, and data processing enable new concepts in radiation detection that are relevant for applications ranging from fundamental physics to medicine as well as nuclear security and safety. We present recent progress in multi-dimensional radiation detection and imaging in the Berkeley Applied Nuclear Physics program. It is based on the ability to reconstruct scenes in three dimensions and fuse it with gamma-ray image information. We are using the High-Efficiency Multimode Imager HEMI in its Compton imaging mode and combining it with contextual sensors such as the Microsoft Kinect or visual cameras. This new concept of volumetric imaging or scene data fusion provides unprecedented capabilities in radiation detection and imaging relevant for the detection and mapping of radiological and nuclear materials. This concept brings us one step closer to the seeing the world with gamma-ray eyes. (author)

CARA, new concept of advanced fuel element for HWR

International Nuclear Information System (INIS)

Florido, P.C.; Crimello, R.O.; Bergallo, J.E.; Marino, A.C.; Delmastro, D.F.; Brasnarof, D.O.; Gonzalez, J.H.

1999-01-01

All Argentinean NPPs (2 in operation, 1 under construction), use heavy water as coolant and moderator. With very different reactor concepts (pressure Vessel and CANDU type designs), the fuel elements are completely different in its concepts too. Argentina produces both types of fuel elements at a manufacturing fuel element company, called CONUAR. The very different fuel element's designs produce a very complex economical behavior in this company, due to the low production scale. The competitiveness of the Argentinean electric system (Argentina has a market driven electric system) put another push towards to increase the economical competitiveness of the nuclear fuel cycle. At present, Argentina has a very active Slightly Enriched Uranium (SEU) Program for the pressure vessel HWR type, but without strong changes in the fuel concept itself. Then, the Atomic Energy Commission in Argentina (CNEA) has developed a new concept of fuel element, named CARA, trying to achieve very ambitious goals, and substantially improved the competitiveness of the nuclear option. The ambitious targets for CARA fuel element are compatibility (a single fuel element for all Argentinean's HWR) using a single diameter fuel rod, improve the security margins, increase the burnup and do not exceed the CANDU fabrication costs. In this paper, the CARA concept will be presented, in order to explained how to achieve all together these goals. The design attracted the interest of the nuclear power operator utility (NASA), and the fuel manufacturing company (CONUAR). Then a new Project is right now under planning with the cooperation of three parts (CNEA - NASA - CONUAR) in order to complete the whole development program in the shortest time, finishing in the commercial production of CARA fuel bundle. At the end of the this paper, future CARA development program will be described. (author)

RASC-AL (Revolutionary Aerospace Systems Concepts-Academic Linkage): 2002 Advanced Concept Design Presentation

Science.gov (United States)

2002-01-01

The Revolutionary Aerospace Systems Concepts-Academic Linkage (RASC-AL) is a program of the Lunar and Planetary Institute (LPI) in collaboration with the Universities Space Research Association's (USRA) ICASE institute through the NASA Langley Research Center. The RASC-AL key objectives are to develop relationships between universities and NASA that lead to opportunities for future NASA research and programs, and to develop aerospace systems concepts and technology requirements to enable future NASA missions. The program seeks to look decades into the future to explore new mission capabilities and discover what's possible. NASA seeks concepts and technologies that can make it possible to go anywhere, at anytime, safely, reliably, and affordably to accomplish strategic goals for science, exploration, and commercialization. University teams were invited to submit research topics from the following themes: Human and Robotic Space Exploration, Orbital Aggregation & Space Infrastructure Systems (OASIS), Zero-Emissions Aircraft, and Remote Sensing. RASC-AL is an outgrowth of the HEDS-UP (University Partners) Program sponsored by the LPI. HEDS-UP was a program of the Lunar and Planetary Institute designed to link universities with NASA's Human Exploration and Development of Space (HEDS) enterprise. The first RASC-AL Forum was held November 5-8, 2002, at the Hilton Cocoa Beach Oceanfront Hotel in Cocoa Beach, Florida. Representatives from 10 university teams presented student research design projects at this year's Forum. Each team contributed a written report and these reports are presented.

Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway

Science.gov (United States)

Shime, Hiroaki; Matsumoto, Misako; Seya, Tsukasa

2017-01-01

PolyI:C, a synthetic double-stranded RNA analog, acts as an immune-enhancing adjuvant that regresses tumors in cytotoxic T lymphocyte (CTL)-dependent and CTL-independent manner, the latter of which remains largely unknown. Tumors contain CD11b+Ly6G+ cells, known as granulocytic myeloid-derived suppressor cells (G-MDSCs) or tumor-associated neutrophils (TANs) that play a critical role in tumor progression and development. Here, we demonstrate that CD11b+Ly6G+ cells respond to polyI:C and exhibit tumoricidal activity in an EL4 tumor implant model. PolyI:C-induced inhibition of tumor growth was attributed to caspase-8/3 cascade activation in tumor cells that occurred independently of CD8α+/CD103+ dendritic cells (DCs) and CTLs. CD11b+Ly6G+ cells was essential for the antitumor effect because depletion of CD11b+Ly6G+ cells totally abrogated tumor regression and caspase activation after polyI:C treatment. CD11b+Ly6G+ cells that had been activated with polyI:C showed cytotoxicity and inhibited tumor growth through the production of reactive oxygen species (ROS)/reactive nitrogen species (RNS). These responses were abolished in either Toll/interleukin-1 receptor domain-containing adaptor molecule-1 (TICAM-1)−/− or interferon (IFN)-αβ receptor 1 (IFNAR1)−/− mice. Thus, our results suggest that polyI:C activates the TLR3/TICAM-1 and IFNAR signaling pathways in CD11b+Ly6G+ cells in tumors, thereby eliciting their antitumor activity, independent of those in CD8α+/CD103+ DCs that prime CTLs. PMID:27834952

Concept Analysis and the Advance of Nursing Knowledge: State of the Science.

Science.gov (United States)

Rodgers, Beth L; Jacelon, Cynthia S; Knafl, Kathleen A

2018-04-24

Despite an overwhelming increase in the number of concept analyses published since the early 1970s, there are significant limitations to the impact of this work in promoting progress in nursing science. We conducted an extensive review of concept analyses published between 1972 and 2017 to identify patterns in analysis and followed this with exploration of an exemplar related to the concept of normalization to demonstrate the capabilities of analysis for promoting concept development and progress. Scoping review of peer-reviewed literature published in the Cumulative Index to Nursing and Allied Health Literature (CINAHL) in which the terms "concept analysis," "concept clarification," and "concept derivation" appeared in any part of the reference. The original search returned 3,489 articles. This initial pool was refined to a final sample of 958 articles published in 223 journals and addressing 604 concepts. A review of citations of the original analysis of the concept of normalization resulted in 75 articles selected for closer examination of the process of concept development. Review showed a clear pattern of repetition of analysis of the same concept, growth in number of published analyses, preponderance of first authors with master's degrees, and 43 distinct descriptions of methods. Review of the 75 citations to the normalization analysis identified multiple ways concept analysis can inform subsequent research and theory development. Conceptual work needs to move beyond the level of "concept analysis" involving clear linkage to the resolution of problems in the discipline. Conceptual work is an important component of progress in the knowledge base of a discipline, and more effective use of concept development activities are needed to maximize the potential of this important work. It is important to the discipline that we facilitate progress in nursing science on a theoretical and conceptual level as a part of cohesive and systematic development of the discipline

Study of advanced fuel system concepts for commercial aircraft

Science.gov (United States)

Coffinberry, G. A.

1985-01-01

An analytical study was performed in order to assess relative performance and economic factors involved with alternative advanced fuel systems for future commercial aircraft operating with broadened property fuels. The DC-10-30 wide-body tri-jet aircraft and the CF6-8OX engine were used as a baseline design for the study. Three advanced systems were considered and were specifically aimed at addressing freezing point, thermal stability and lubricity fuel properties. Actual DC-10-30 routes and flight profiles were simulated by computer modeling and resulted in prediction of aircraft and engine fuel system temperatures during a nominal flight and during statistical one-day-per-year cold and hot flights. Emergency conditions were also evaluated. Fuel consumption and weight and power extraction results were obtained. An economic analysis was performed for new aircraft and systems. Advanced system means for fuel tank heating included fuel recirculation loops using engine lube heat and generator heat. Environmental control system bleed air heat was used for tank heating in a water recirculation loop. The results showed that fundamentally all of the three advanced systems are feasible but vary in their degree of compatibility with broadened-property fuel.

Clinical and immunological evaluation of anti-apoptosis protein, survivin-derived peptide vaccine in phase I clinical study for patients with advanced or recurrent breast cancer

Directory of Open Access Journals (Sweden)

Asanuma Hiroko

2008-05-01

Full Text Available Abstract Background We previously reported that survivin-2B, a splicing variant of survivin, was expressed in various types of tumors and that survivin-2B peptide might serve as a potent immunogenic cancer vaccine. The objective of this study was to examine the toxicity of and to clinically and immunologically evaluate survivin-2B peptide in a phase I clinical study for patients with advanced or recurrent breast cancer. Methods We set up two protocols. In the first protocol, 10 patients were vaccinated with escalating doses (0.1–1.0 mg of survivin-2B peptide alone 4 times every 2 weeks. In the second protocol, 4 patients were vaccinated with the peptide at a dose of 1.0 mg mixed with IFA 4 times every 2 weeks. Results In the first protocol, no adverse events were observed during or after vaccination. In the second protocol, two patients had induration at the injection site. One patient had general malaise (grade 1, and another had general malaise (grade 1 and fever (grade 1. Peptide vaccination was well tolerated in all patients. In the first protocol, tumor marker levels increased in 8 patients, slightly decreased in 1 patient and were within the normal range during this clinical trial in 1 patient. With regard to tumor size, two patients were considered to have stable disease (SD. Immunologically, in 3 of the 10 patients (30%, an increase of the peptide-specific CTL frequency was detected. In the second protocol, an increase of the peptide-specific CTL frequency was detected in all 4 patients (100%, although there were no significant beneficial clinical responses. ELISPOT assay showed peptide-specific IFN-γ responses in 2 patients in whom the peptide-specific CTL frequency in tetramer staining also was increased in both protocols. Conclusion This phase I clinical study revealed that survivin-2B peptide vaccination was well tolerated. The vaccination with survivin-2B peptide mixed with IFA increased the frequency of peptide-specific CTL more

Advancing Empirical Approaches to the Concept of Resilience: A Critical Examination of Panarchy, Ecological Information, and Statistical Evidence

Directory of Open Access Journals (Sweden)

Ali Kharrazi

2016-09-01

Full Text Available Despite its ambiguities, the concept of resilience is of critical importance to researchers, practitioners, and policy-makers in dealing with dynamic socio-ecological systems. In this paper, we critically examine the three empirical approaches of (i panarchy; (ii ecological information-based network analysis; and (iii statistical evidence of resilience to three criteria determined for achieving a comprehensive understanding and application of this concept. These criteria are the ability: (1 to reflect a system’s adaptability to shocks; (2 to integrate social and environmental dimensions; and (3 to evaluate system-level trade-offs. Our findings show that none of the three currently applied approaches are strong in handling all three criteria. Panarchy is strong in the first two criteria but has difficulty with normative trade-offs. The ecological information-based approach is strongest in evaluating trade-offs but relies on common dimensions that lead to over-simplifications in integrating the social and environmental dimensions. Statistical evidence provides suggestions that are simplest and easiest to act upon but are generally weak in all three criteria. This analysis confirms the value of these approaches in specific instances but also the need for further research in advancing empirical approaches to the concept of resilience.

Atmospheric fluidized bed combustion advanced system concepts applicable to small industrial and commercial markets. Topical report, Level 2

Energy Technology Data Exchange (ETDEWEB)

Ake, T.R.; Dixit, V.B.; Mongeon, R.K.

1992-09-01

As part of an overall strategy to promote FBC coal combustion and to improve the marketability of the eastern coals, the US Department of Energy`s Morgantown Energy Research Center awarded a three level contract to Riley Stoker Corporation to develop advanced Multi Solids Fluidized Bed (MSFB) boiler designs. The first level of this contract targeted the small package boiler (10,000--50,000 lb/hr steam) and industrial size boiler (75,000--150,000 lb/hr steam) markets. Two representative sizes, 30,000 lb/hr and 110,000 lb/hr of steam, were selected for the two categories for a detailed technical and economic evaluation. Technically, both the designs showed promise, however, the advanced industrial design was favored on economic considerations. It was thus selected for further study in the second level of the contract. Results of this Level-2 effort, presented in this report, consisted of testing the design concept in Riley`s 4.4 MBtu/hr pilot MSFB facility located at Riley Research Center in Worcester, Mass. The design and economics of the proof of concept facility developed in Level-1 of the contract were then revised in accordance with the findings of the pilot test program. A host site for commercial demonstration in Level-3 of the contract was also secured. It was determined that co-firing coal in combination with paper de-inking sludge will broaden the applicability of the design beyond conventional markets. International Paper (IP), the largest paper company in the world, is willing to participate in this part of the program. IP has offered its Hammermill operation at Lockhaven, Pa, site of a future paper de-inking plant, for the proof of concept installation. This plant will go in operation in 1994. It is recommended that METC proceed to the commercial demonstration of the design developed. The approach necessary to satisfy the needs of the customer while meeting the objectives of this program is presented along with a recommended plan of action.

Technology Alignment and Portfolio Prioritization (TAPP): Advanced Methods in Strategic Analysis, Technology Forecasting and Long Term Planning for Human Exploration and Operations, Advanced Exploration Systems and Advanced Concepts

Science.gov (United States)

Funaro, Gregory V.; Alexander, Reginald A.

2015-01-01

The Advanced Concepts Office (ACO) at NASA, Marshall Space Flight Center is expanding its current technology assessment methodologies. ACO is developing a framework called TAPP that uses a variety of methods, such as association mining and rule learning from data mining, structure development using a Technological Innovation System (TIS), and social network modeling to measure structural relationships. The role of ACO is to 1) produce a broad spectrum of ideas and alternatives for a variety of NASA's missions, 2) determine mission architecture feasibility and appropriateness to NASA's strategic plans, and 3) define a project in enough detail to establish an initial baseline capable of meeting mission objectives ACO's role supports the decision­-making process associated with the maturation of concepts for traveling through, living in, and understanding space. ACO performs concept studies and technology assessments to determine the degree of alignment between mission objectives and new technologies. The first step in technology assessment is to identify the current technology maturity in terms of a technology readiness level (TRL). The second step is to determine the difficulty associated with advancing a technology from one state to the next state. NASA has used TRLs since 1970 and ACO formalized them in 1995. The DoD, ESA, Oil & Gas, and DoE have adopted TRLs as a means to assess technology maturity. However, "with the emergence of more complex systems and system of systems, it has been increasingly recognized that TRL assessments have limitations, especially when considering [the] integration of complex systems." When performing the second step in a technology assessment, NASA requires that an Advancement Degree of Difficulty (AD2) method be utilized. NASA has used and developed or used a variety of methods to perform this step: Expert Opinion or Delphi Approach, Value Engineering or Value Stream, Analytical Hierarchy Process (AHP), Technique for the Order of

Tokamak concept innovations

International Nuclear Information System (INIS)

1986-04-01

This document contains the results of the IAEA Specialists' Meeting on Tokamak Concept Innovations held 13-17 January 1986 in Vienna. Although it is the most advanced fusion reactor concept the tokamak is not without its problems. Most of these problems should be solved within the ongoing R and D studies for the next generation of tokamaks. Emphasis for this meeting was placed on innovations that would lead to substantial improvements in a tokamak reactor, even if they involved a radical departure from present thinking

Final Project Report "Advanced Concept Exploration For Fast Ignition Science Program"

Energy Technology Data Exchange (ETDEWEB)

STEPHENS, Richard B.; McLEAN, Harry M.; THEOBALD, Wolfgang; AKLI, Kramer; BEG, Farhat N.; SENTOKU, Yasuiko; SCHUMACHER, Douglas; WEI, Mingsheng S.

2014-01-31

The Fast Ignition (FI) Concept for Inertial Confinement Fusion has the potential to provide a significant advance in the technical attractiveness of Inertial Fusion Energy (IFE) reactors. FI differs from conventional “central hot spot” (CHS) target ignition by decoupling compression from heating: using the laser (or heavy ion beam or Z pinch) drive pulse (10’s of ns) to create a dense fuel and a second, much shorter (~10 ps) high intensity pulse to ignite a small region of it. There are two major physics issues concerning this concept; controlling the laser-induced generation of large electron currents and their propagation through high density plasmas. This project has addressed these two significant scientific issues in Relativistic High Energy Density (RHED) physics. Learning to control relativistic laser matter interaction (and the limits and potential thereof) will enable a wide range of applications. While these physics issues are of specific interest to inertial fusion energy science, they are also important for a wide range of other HED phenomena, including high energy ion beam generation, isochoric heating of materials, and the development of high brightness x-ray sources. Generating, controlling, and understanding the extreme conditions needed to advance this science has proved to be challenging: Our studies have pushed the boundaries of physics understanding and are at the very limits of experimental, diagnostic, and simulation capabilities in high energy density laboratory physics (HEDLP). Our research strategy has been based on pursuing the fundamental physics underlying the Fast Ignition (FI) concept. We have performed comprehensive study of electron generation and transport in fast-ignition targets with experiments, theory, and numerical modeling. A major issue is that the electrons produced in these experiments cannot be measured directly—only effects due to their transport. We focused mainly on x-ray continuum photons from bremsstrahlung

Reference Operational Concepts for Advanced Nuclear Power Plants

Energy Technology Data Exchange (ETDEWEB)

Hugo, Jacques Victor [Idaho National Lab. (INL), Idaho Falls, ID (United States); Farris, Ronald Keith [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-09-01

This report represents the culmination of a four-year research project that was part of the Instrumentation and Control and Human Machine Interface subprogram of the DOE Advanced Reactor Technologies program.

Parabolic Flight Investigation for Advanced Exercise Concept Hardware Hybrid Ultimate Lifting Kit (HULK)

Science.gov (United States)

Weaver, A. S.; Funk, J. H.; Funk, N. W.; Sheehan, C. C.; Humphreys, B. T.; Perusek, G. P.

2015-01-01

Long-duration space flight poses many hazards to the health of the crew. Among those hazards is the physiological deconditioning of the musculoskeletal and cardiovascular systems due to prolonged exposure to microgravity. To combat this erosion of physical condition space flight may take on the crew, the Human Research Program (HRP) is charged with developing Advanced Exercise Concepts to maintain astronaut health and fitness during long-term missions, while keeping device mass, power, and volume to a minimum. The goal of this effort is to preserve the physical capability of the crew to perform mission critical tasks in transit and during planetary surface operations. The HULK is a pneumatic-based exercise system, which provides both resistive and aerobic modes to protect against human deconditioning in microgravity. Its design targeted the International Space Station (ISS) Advanced Resistive Exercise Device (ARED) high level performance characteristics and provides up to 600 foot pounds resitive loading with the capability to allow for eccentric to concentric (E:C) ratios of higher than 1:1 through a DC motor assist component. The device's rowing mode allows for high cadence aerobic activity. The HULK parabolic flight campaign, conducted through the NASA Flight Opportunities Program at Ellington Field, resulted in the creation of device specific data sets including low fidelity motion capture, accelerometry and both inline and ground reaction forces. These data provide a critical link in understanding how to vibration isolate the device in both ISS and space transit applications. Secondarily, the study of human exercise and associated body kinematics in microgravity allows for more complete understanding of human to machine interface designs to allow for maximum functionality of the device in microgravity.

Mobility disorders and pain, interrelations that need new research concepts and advanced clinical commitments

Directory of Open Access Journals (Sweden)

Sascha Sajer

2017-12-01

Full Text Available This Perspective will discuss topics recently suggested by Prof. Helmut Kern, Vienna, Austria, to advance the research activities of his team, that is: Topic A, 10 years post RISE; Topic B, New research for new solutions on old research questions; Topic C, Working groups on nerve regeneration, training-parameters of seniors in different ages, muscle adaptation; and studies of connective tissue and cartilage. This Perspective summarizes some of the basic concepts and of the evidence-based tools for developing further translational research activities. Clinically relevant results will ask for continuous interests of Basic and Applied Myologists and for the support during the next five to ten years of public and private granting agencies. All together, they will end in protocols, devices and multidisciplinary managements for persons suffering with muscle denervation, neuromuscular-related or non-related pain and for the increasing population of old, older and oldest senior citizens in Europe and beyond.

Mini Literature Review of Self-Concept

Directory of Open Access Journals (Sweden)

Aida Mehrad

2016-08-01

Full Text Available The aim of the current literature review is to focus on individuals´ self-concept. The results of the present study reveal that self-concept assumed as an important factor for each and can change his or her belief, attitude, and reaction toward personal and social life. This study likewise explained the beginning of self-concept, different views toward this vital factor, the role of introspection, and multicultural. Furthermore, this paper supported the imperative of self-concept; additionally, it has an essential role in individual advance.

Concept selection for advanced low-emission coal fired boiler

Energy Technology Data Exchange (ETDEWEB)

Gorrell, R.L. [Babcock and Wilcox Co., Barberton, OH (United States); Rodgers, L.W.; Farthing, G.A. [Babcock and Wilcox Co., Alliance, OH (United States)

1993-12-31

The Babcock & Wilcox Company (B&W), under contract to the US Department of Energy (DOE) with subcontract to Physical Sciences, Inc. (PSIT), the Massachusetts Institute of Technology (MIT) and United Engineers and Constructors (UE&C) has begun development of an advanced low-emission boiler system (LEBS). The initial phase of this multi-phase program required a thorough review and assessment of potential advanced technologies and techniques for control of combustion and flue gas emissions. Results of this assessment are presented in this paper.

Advanced supersonic propulsion study, phase 3

Science.gov (United States)

Howlett, R. A.; Johnson, J.; Sabatella, J.; Sewall, T.

1976-01-01

The variable stream control engine is determined to be the most promising propulsion system concept for advanced supersonic cruise aircraft. This concept uses variable geometry components and a unique throttle schedule for independent control of two flow streams to provide low jet noise at takeoff and high performance at both subsonic and supersonic cruise. The advanced technology offers a 25% improvement in airplane range and an 8 decibel reduction in takeoff noise, relative to first generation supersonic turbojet engines.

Leading change: a concept analysis.

Science.gov (United States)

Nelson-Brantley, Heather V; Ford, Debra J

2017-04-01

To report an analysis of the concept of leading change. Nurses have been called to lead change to advance the health of individuals, populations, and systems. Conceptual clarity about leading change in the context of nursing and healthcare systems provides an empirical direction for future research and theory development that can advance the science of leadership studies in nursing. Concept analysis. CINAHL, PubMed, PsycINFO, Psychology and Behavioral Sciences Collection, Health Business Elite and Business Source Premier databases were searched using the terms: leading change, transformation, reform, leadership and change. Literature published in English from 2001 - 2015 in the fields of nursing, medicine, organizational studies, business, education, psychology or sociology were included. Walker and Avant's method was used to identify descriptions, antecedents, consequences and empirical referents of the concept. Model, related and contrary cases were developed. Five defining attributes of leading change were identified: (a) individual and collective leadership; (b) operational support; (c) fostering relationships; (d) organizational learning; and (e) balance. Antecedents were external or internal driving forces and organizational readiness. The consequences of leading change included improved organizational performance and outcomes and new organizational culture and values. A theoretical definition and conceptual model of leading change were developed. Future studies that use and test the model may contribute to the refinement of a middle-range theory to advance nursing leadership research and education. From this, empirically derived interventions that prepare and enable nurses to lead change to advance health may be realized. © 2016 John Wiley & Sons Ltd.

Advanced Electron Linacs

Energy Technology Data Exchange (ETDEWEB)

Siemann, R.

2005-02-14

The research into advanced acceleration concepts for electron linear accelerators being pursued at SLAC is reviewed. This research includes experiments in laser acceleration, plasma wakefield acceleration, and mmwavelength RF driven accelerators.

Advanced Level Physics Students' Conceptions of Quantum Physics.

Science.gov (United States)

Mashhadi, Azam

This study addresses questions about particle physics that focus on the nature of electrons. Speculations as to whether they are more like particles or waves or like neither illustrate the difficulties with which students are confronted when trying to incorporate the concepts of quantum physics into their overall conceptual framework. Such…

Using Concept Maps in Political Science

Science.gov (United States)

Chamberlain, Robert P.

2015-01-01

Concept mapping is a pedagogical technique that was developed in the 1970s and is being used in K-12 and postsecondary education. Although it has shown excellent results in other fields, it is still rare in political science. In this research note, I discuss the implementation and testing of concept mapping in my Advanced Introduction to…

LDRD Final Report: Advanced Hohlraum Concepts

Energy Technology Data Exchange (ETDEWEB)

Jones, Ogden S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2017-11-08

Indirect drive inertial confinement fusion (ICF) experiments to date have mostly used cylindrical, laser-heated, gas-filled hohlraums to produce the radiation drive needed to symmetrically implode DT-filled fusion capsules. These hohlraums have generally been unable to produce a symmetric radiation drive through the end of the desired drive pulse, and are plagued with complications due to laser-plasma interactions (LPI) that have made it difficult to predict their performance. In this project we developed several alternate hohlraum concepts. These new hohlraums utilize different hohlraum geometries, radiation shields, and foam materials in an attempt to improve performance relative to cylindrical hohlraums. Each alternate design was optimized using radiation hydrodynamic (RH) design codes to implode a reference DT capsule with a high-density carbon (HDC) ablator. The laser power and energy required to produce the desired time-dependent radiation drive, and the resulting time-dependent radiation symmetry for each new concept were compared to the results for a reference cylindrical hohlraum. Since several of the new designs needed extra laser entrance holes (LEHs), techniques to keep small LEHs open longer, including high-Z foam liners and low-Z wires at the LEH axis, were investigated numerically. Supporting experiments and target fabrication efforts were also done as part of this project. On the Janus laser facility plastic tubes open at one end (halfraums) and filled with SiO₂ or Ta₂O₅ foam were heated with a single 2w laser. Laser propagation and backscatter were measured. Generally the measured propagation was slower than calculated, and the measured laser backscatter was less than calculated. A comparable, scaled up experiment was designed for the NIF facility and four targets were built. Since low density gold foam was identified as a desirable material for lining the LEH and the hohlraum wall, a technique was developed to

Review of advanced core designs for LMFBRs

International Nuclear Information System (INIS)

Yoshida, Kazuo

1986-01-01

It is a matter of great importance for the development of LMFBR to reduce its power cost to the level of the other power generating means. For this purpose, some ideas that use advanced core concepts to reduce LMFBR's power cost by improving its fuel cycle economics have recently been proposed. In this report, two hopeful ideas that use advanced core concepts: (1) Ultra Long Life Core (ULLC) - non-refueling over LMFBR power plant life; (2) Integral Fast Reactor (IFR) concept - metal fueled core and pyrometallurgical reprocessing; are picked up and their economical effect and technical probrems are investigated. (author)

Economics Foundations for an Entrepreneurial Marketing Concept

DEFF Research Database (Denmark)

Duus, Henrik Johannsen

1997-01-01

and its strategy, parts of the essence of the marketing concept are being challenged. This article proposes that a new entrepreneurial marketing concept based on an ex-ante supply-push conception of marketing, and which focuses on future market demands and the future capabilities of the firm......This article examines developments in economics and strategic management theory and discusses their implications for marketing. Recent advances in economic theory have suggested new inputs to marketing management theory and practice. With the advance of the “new economic theories” of the firm......, will be capable of solving these problems. Possible elements in a new approach are suggested. The focus is on industrial marketing, very long-term and very general environmental analysis, and on innovation, industrial transformation and the building of the competencies of the firm....

Advanced Technologies Addressing Asia-Pacific Infectious Diseases

Science.gov (United States)

2011-01-01

outbreak in Malaysia in 1998-1999 threaten to spread beyond borders as finally demonstrated by the outbreak of severe acute respiratory syndrome (SARS) in...independent manner, which underwent less apoptosis, and could expand ex vivo Epstein-Barr virus (EBV)-specific CTL responses from healthy human...former smokers. By history, 5 had dyslipidemia (all diet controlled), 3 had a diagnosis of hypertension (all treated with anti-hypertensive

Advanced Propulsion Study

National Research Council Canada - National Science Library

Davis, Eric

2004-01-01

... that show promise of leading to a major advance in Earth-to-orbit (ETO) propulsion. The study also reviewed and evaluated a select number of credible far-term breakthrough propulsion physics concepts pertaining...

A Metal Fuel Core Concept for 1000 MWt Advanced Burner Reactor

International Nuclear Information System (INIS)

Yang, W.S.; Kim, T.K.; Grandy, C.

2007-01-01

This paper describes the core design and performance characteristics of a metal fuel core concept for a 1000 MWt Advanced Burner Reactor. A ternary metal fuel form of U-TRU-Zr was assumed with weapons grade plutonium feed for the startup core and TRU recovered from LWR spent fuel for the recycled equilibrium core. A compact burner core was developed by trade-off between the burnup reactivity loss and TRU conversion ratio, with a fixed cycle length of one-year. In the startup core, the average TRU enrichment is 15.5%, the TRU conversion ratio is 0.81, and the burnup reactivity loss over a cycle is 3.6% Δk. The heavy metal and TRU inventories are 13.1 and 2.0 metric tons, respectively. The average discharge burnup is 93 MWd/kg, and the TRU consumption rate is 55.5 kg/year. For the recycled equilibrium core, the average TRU enrichment is 22.1 %, the TRU conversion ratio is 0.73, and the burnup reactivity loss is 2.2% Δk. The TRU inventory and consumption rate are 2.9 metric tons and 81.6 kg/year, respectively. The evaluated reactivity coefficients provide sufficient negative feedbacks. The control systems provide shutdown margins that are more than adequate. The integral reactivity parameters for quasi-static reactivity balance analysis indicate favorable passive safety features, although detailed safety analyses are required to verify passive safety behavior. (authors)

Microwave and particle beam sources and directed energy concepts

International Nuclear Information System (INIS)

Brandt, H.E.

1989-01-01

This book containing the proceedings of the SPIE on microwave and particle beam sources and directed energy concepts. Topics covered include: High power microwave sources, Direct energy concepts, Advanced accelerators, and Particle beams

Concepts and recent advances in generalized information measures and statistics

CERN Document Server

Kowalski, Andres M

2013-01-01

Since the introduction of the information measure widely known as Shannon entropy, quantifiers based on information theory and concepts such as entropic forms and statistical complexities have proven to be useful in diverse scientific research fields. This book contains introductory tutorials suitable for the general reader, together with chapters dedicated to the basic concepts of the most frequently employed information measures or quantifiers and their recent applications to different areas, including physics, biology, medicine, economics, communication and social sciences. As these quantif

Organization of the 17th Advanced Accelerator Concepts (AAC16) Workshop by the IEEE. Final Scientific/Technical Report On AWARD NO. DE-SC0015635

Energy Technology Data Exchange (ETDEWEB)

Sutter, David F. [Inst. of Electrical and Electronics Engineers Inc., Piscataway, NJ (United States)

2017-07-15

The 2016 Workshop on Advanced Accelerator Concepts (AAC) was held at the Gaylord Hotel and Conference Center, National Harbor, Maryland, from July 31 through August 5, 2016. This workshop was the seventeenth in a biennial series that began at Los Alamos National Laboratory in 1982 with a workshop on laser acceleration of particles (see AIP Conf. Proc. 91). AAC16 was organized under the sponsorship of the IEEE Council on Superconductivity with financial support from the U. S. Department of Energy Office of High Energy Physics and the National Science Foundation. The scope of the AAC Workshop has grown since 1982 to encompass a broad range of topics related to advancing accelerator science and technology beyond its current scientific and technical limits and is now an internationally acknowledged forum for interdisciplinary discussions on advanced accelerator and beam physics/technology concepts covering the widest possible range of applications. The Workshop continued the trend of growing worldwide participation, attracting world wide participation. The Workshop had a total of 256 attendees comprising (including the U.S.) representatives from 11 countries representing 65 different institutions. Each day’s schedule began with plenary sessions covering broad, cross disciplinary interests or general tutorial topics as selected by the Program Committee, followed by a break out into more narrowly focused working groups. The Workshop was organized into eight Working Groups each with a published statement of topical focus, scope of discussion and goals. A summary of the Working Group activities and conclusions is included in the American Institute of Physics’ (AIP) Conference Proceedings now available as an on line open source document. It has been a long tradition of the AAC workshops to encourage strong student participation. This is accomplished in part by subsidizing student attendance, done for this work shop by using funds from the DOE and National Science

Staff nurse clinical leadership: a concept analysis.

Science.gov (United States)

Chávez, Eduardo C; Yoder, Linda H

2015-01-01

The purpose of this article is to provide a concept analysis of staff nurse clinical leadership (SNCL). A clear delineation of SNCL will promote understanding and encourage communication of the phenomenon. Clarification of the concept will establish a common understanding of the concept, and advance the practice, education, and research of this phenomenon. A review of the literature was conducted using several databases. The databases were searched using the following keywords: clinical leadership, nursing, bedside, staff nurse, front-line, front line, and leadership. The search yielded several sources; however, only those that focused on clinical leadership demonstrated by staff nurses in acute care hospital settings were selected for review. SNCL is defined as staff nurses who exert significant influence over other individuals in the healthcare team, and although no formal authority has been vested in them facilitates individual and collective efforts to accomplish shared clinical objectives. The theoretical definition for SNCL within the team context will provide a common understanding of this concept and differentiate it from other types of leadership in the nursing profession. This clarification and conceptualization of the concept will assist further research of the concept and advance its practical application in acute care hospital settings. © 2014 Wiley Periodicals, Inc.

Advancing Democratic Leadership through Critical Theory.

Science.gov (United States)

Lees, Kimberly A.

1995-01-01

Examines how the concepts advanced by critical theorists exemplify democratic leadership. The concept of democratic leadership is explored as a moral imperative of human issues, and the implications of leadership behavior that emulate the principles of democracy are discussed. (SLD)

Advanced calculus

CERN Document Server

Nickerson, HK; Steenrod, NE

2011-01-01

""This book is a radical departure from all previous concepts of advanced calculus,"" declared the Bulletin of the American Mathematics Society, ""and the nature of this departure merits serious study of the book by everyone interested in undergraduate education in mathematics."" Classroom-tested in a Princeton University honors course, it offers students a unified introduction to advanced calculus. Starting with an abstract treatment of vector spaces and linear transforms, the authors introduce a single basic derivative in an invariant form. All other derivatives - gradient, divergent, curl,

Quality of experience advanced concepts, applications and methods

CERN Document Server

Raake, Alexander

2014-01-01

This pioneering book develops definitions and concepts related to Quality of Experience in the context of multimedia- and telecommunications-related applications, systems and services, and applies these to various fields of communication and media technologies. The editors bring together numerous key-protagonists of the new discipline “Quality of Experience” and combine the state-of-the-art knowledge in one single volume. 

Red Teaming of Advanced Information Assurance Concepts

International Nuclear Information System (INIS)

DUGGAN, RUTH A.; WOOD, BRADLEY

1999-01-01

Red Teaming is an advanced form of assessment that can be used to identify weaknesses in a variety of cyber systems. it is especially beneficial when the target system is still in development when designers can readily affect improvements. This paper discusses the red team analysis process and the author's experiences applying this process to five selected Information Technology Office (ITO) projects. Some detail of the overall methodology, summary results from the five projects, and lessons learned are contained within this paper

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells

International Nuclear Information System (INIS)

Bradley, S.M.; Kruisbeek, A.M.; Singer, A.

1982-01-01

The present report has used fully H-2 allogeneic radiation bone marrow chimeras to assess the role of host restriction elements in determining the self-specificity of Ia- and H-2K/D-restricted T cells that participate in the generation of trinitrophenyl (TNP)-specific cytotoxic T lymphocytes (CTL). It was demonstrated that there exists a stringent requirement for the recognition of host thymic-type Ia determinants, but there exists only a preference for host thymic-type H-2K/D determinants. Indeed, once the stringent requirement for recognition of host Ia determinants was fulfilled, anti-TNP CTL were generated in response to TNP-modified stimulators that expressed either donor-type or host-type H-2K/D determinants. The CTL that were generated in response to TNP-modified donor-type stimulators were shown to be specific for TNP and restricted to the non-thymic H-2K/D determinants of the chimeric donor. Thus, these results demonstrate in a single immune response that the thymic hypothesis accurately predicts the self-specificity expressed by Ia-restricted T cells, but does not fully account for the self-specificity expressed by H-2K/D-restricted T cells. These results are consistent with the concept that H-2K/D-restricted T cells, but not Ia-restricted T cells, can differentiate into functional competence either intrathymically or extra-thymically. The results demonstrate that the generation of anti-TNP CTL responses involve two parallel sets of major histocompatibility complex-restricted cell interactions, an Ia-restricted TH-accessory cell interaction required for TH cell activation, and an H-2K/D-restricted pCTL-stimulator cell interaction required for pCTL stimulation. The interaction between activated TH cells and stimulated pCTL is mediated, at least in part, by nonspecific soluble helper factors

THE DEVELOPMENT OF ELECTRONIC TEACHING MATERIALS BY FLIPBOOK ASSISTANCE BASED PROBLEM SOLVING SKILL WITH CTL APPROACH ON LEARNING MATHEMATICS CLASS V

Directory of Open Access Journals (Sweden)

RUSNILAWATI Eva Gustiana RUSNILAWATI

2018-01-01

Full Text Available The purpose of this research is to produce Flipbook-based Electronic Teaching Materials (BAE based on problem solving skills with CTL Approach on Vocational School Class V learning valid, practical, and effective. This type of research is development research (Development Research. This research developed Flipbook-assisted Electronic Teaching Materials (BAE on the mathematics learning of Class V Primary School by using the 4-D development model developed by Thiagarajan, Semmel, and Semmel. The validation results show that the developed Teaching Materials are worthy of use with a good minimum category. The results of the experiments show that Electronic Materials developed are practical and effective. Completed learning in the classical has reached the minimum criteria of 75% that is for problem-solving test reached 86%. Based on a questionnaire of attitudes toward mathematics, 88% of students showed an increase in attitude scores on mathematics, and 85% of students showed attitudes toward mathematics with a good minimum category.

Advanced Hydrogen Turbine Development

Energy Technology Data Exchange (ETDEWEB)

Marra, John [Siemens Energy, Inc., Orlando, FL (United States)

2015-09-30

Under the sponsorship of the U.S. Department of Energy (DOE) National Energy Technology Laboratories, Siemens has completed the Advanced Hydrogen Turbine Development Program to develop an advanced gas turbine for incorporation into future coal-based Integrated Gasification Combined Cycle (IGCC) plants. All the scheduled DOE Milestones were completed and significant technical progress was made in the development of new technologies and concepts. Advanced computer simulations and modeling, as well as subscale, full scale laboratory, rig and engine testing were utilized to evaluate and select concepts for further development. Program Requirements of: A 3 to 5 percentage point improvement in overall plant combined cycle efficiency when compared to the reference baseline plant; 20 to 30 percent reduction in overall plant capital cost when compared to the reference baseline plant; and NOx emissions of 2 PPM out of the stack. were all met. The program was completed on schedule and within the allotted budget

Advances in laser solenoid fusion reactor design

International Nuclear Information System (INIS)

Steinhauer, L.C.; Quimby, D.C.

1978-01-01

The laser solenoid is an alternate fusion concept based on a laser-heated magnetically-confined plasma column. The reactor concept has evolved in several systems studies over the last five years. We describe recent advances in the plasma physics and technology of laser-plasma coupling. The technology advances include progress on first walls, inner magnet design, confinement module design, and reactor maintenance. We also describe a new generation of laser solenoid fusion and fusion-fission reactor designs

Design options for advanced manned launch systems

Science.gov (United States)

Freeman, Delma C.; Talay, Theodore A.; Stanley, Douglas O.; Lepsch, Roger A.; Wilhite, Alan W.

1995-03-01

Various concepts for advanced manned launch systems are examined for delivery missions to space station and polar orbit. Included are single-and two-stage winged systems with rocket and/or air-breathing propulsion systems. For near-term technologies, two-stage reusable rocket systems are favored over single-stage rocket or two-stage air-breathing/rocket systems. Advanced technologies enable viable single-stage-to-orbit (SSTO) concepts. Although two-stage rocket systems continue to be lighter in dry weight than SSTO vehicles, advantages in simpler operations may make SSTO vehicles more cost-effective over the life cycle. Generally, rocket systems maintain a dry-weight advantage over air-breathing systems at the advanced technology levels, but to a lesser degree than when near-term technologies are used. More detailed understanding of vehicle systems and associated ground and flight operations requirements and procedures is essential in determining quantitative discrimination between these latter concepts.

An Overview of Advanced Concepts for Launch

Science.gov (United States)

2012-02-09

Weekly Launches” -Inspect & Rebuild. • SSTO -LOx/LH2: ms < 10% -Advanced Structure/Tank. -Aerospike. -Sensitive Design Space. Reusable... SSTO do not guarantee $ savings. 18 0 50 100 150 200 250 300 0 5000 10000 15000 20000 25000 La un ch C os t ( $ M ill io n) Payload to 185km...Higher reaction temp. •Higher specific impulse. •Less fuel. •More payload or smaller vehicle. •Fewer stages  SSTO . E/mmH = 138MJ/kg H2/mH = 3

Engaging Pre-Service Teachers to Teach Science Contextually with Scientific Approach Instructional Video

Science.gov (United States)

Susantini, E.; Kurniasari, I.; Fauziah, A. N. M.; Prastowo, T.; Kholiq, A.; Rosdiana, L.

2018-01-01

Contextual teaching and learning/CTL presents new concepts in real-life experiences and situations where students can find out the meaningful relationship between abstract ideas and practical applications. Implementing contextual teaching by using scientific approach will foster teachers to find the constructive ways of delivering and organizing science content. This research developed an instructional video that represented a modeling of using a scientific approach in CTL. The aim of this research are to engage pre-service teachers in learning how to teach CTL and to show how pre-service teachers’ responses about learning how to teach CTL using an instructional video. The subjects of this research were ten pre-service teachers in Department of Natural Sciences, Universitas Negeri Surabaya, Indonesia. All subjects observed the instructional video which demonstrated contextual teaching and learning combined with the scientific approach as they completed a worksheet to analyze the video content. The results showed that pre-service teachers could learn to teach contextually as well as applying the scientific approach in science classroom through a modeling in the instructional video. They also responded that the instructional video could help them to learn to teach each component contextual teaching as well as scientific approach.

Modelling Accident Tolerant Fuel Concepts

Energy Technology Data Exchange (ETDEWEB)

Hales, Jason Dean [Idaho National Laboratory; Gamble, Kyle Allan Lawrence [Idaho National Laboratory

2016-05-01

The catastrophic events that occurred at the Fukushima-Daiichi nuclear power plant in 2011 have led to widespread interest in research of alternative fuels and claddings that are proposed to be accident tolerant. The United States Department of Energy (DOE) through its Nuclear Energy Advanced Modeling and Simulation (NEAMS) program has funded an Accident Tolerant Fuel (ATF) High Impact Problem (HIP). The ATF HIP is a three-year project to perform research on two accident tolerant concepts. The final outcome of the ATF HIP will be an in-depth report to the DOE Advanced Fuels Campaign (AFC) giving a recommendation on whether either of the two concepts should be included in their lead test assembly scheduled for placement into a commercial reactor in 2022. The two ATF concepts under investigation in the HIP are uranium silicide fuel and iron-chromium-aluminum (FeCrAl) alloy cladding. Utilizing the expertise of three national laboratory participants (Idaho National Laboratory, Los Alamos National Laboratory, and Argonne National Laboratory), a comprehensive multiscale approach to modeling is being used that includes atomistic modeling, molecular dynamics, rate theory, phase-field, and fuel performance simulations. Model development and fuel performance analysis are critical since a full suite of experimental studies will not be complete before AFC must prioritize concepts for focused development. In this paper, we present simulations of the two proposed accident tolerance fuel systems: U3Si2 fuel with Zircaloy-4 cladding, and UO2 fuel with FeCrAl cladding. Sensitivity analyses are completed using Sandia National Laboratories’ Dakota software to determine which input parameters (e.g., fuel specific heat) have the greatest influence on the output metrics of interest (e.g., fuel centerline temperature). We also outline the multiscale modelling approach being employed. Considerable additional work is required prior to preparing the recommendation report for the Advanced

Oncology Advanced Practitioners Bring Advanced Community Oncology Care.

Science.gov (United States)

Vogel, Wendy H

2016-01-01

Oncology care is becoming increasingly complex. The interprofessional team concept of care is necessary to meet projected oncology professional shortages, as well as to provide superior oncology care. The oncology advanced practitioner (AP) is a licensed health care professional who has completed advanced training in nursing or pharmacy or has completed training as a physician assistant. Oncology APs increase practice productivity and efficiency. Proven to be cost effective, APs may perform varied roles in an oncology practice. Integrating an AP into an oncology practice requires forethought given to the type of collaborative model desired, role expectations, scheduling, training, and mentoring.

Readiness for hospital discharge: A concept analysis.

Science.gov (United States)

Galvin, Eileen Catherine; Wills, Teresa; Coffey, Alice

2017-11-01

To report on an analysis on the concept of 'readiness for hospital discharge'. No uniform operational definition of 'readiness for hospital discharge' exists in the literature; therefore, a concept analysis is required to clarify the concept and identify an up-to-date understanding of readiness for hospital discharge. Clarity of the concept will identify all uses of the concept; provide conceptual clarity, an operational definition and direction for further research. Literature review and concept analysis. A review of literature was conducted in 2016. Databases searched were: Academic Search Complete, CINAHL Plus with Full Text, PsycARTICLES, Psychology and Behavioural Sciences Collection, PsycINFO, Social Sciences Full Text (H.W. Wilson) and SocINDEX with Full Text. No date limits were applied. Identification of the attributes, antecedents and consequences of readiness for hospital discharge led to an operational definition of the concept. The following attributes belonging to 'readiness for hospital discharge' were extracted from the literature: physical stability, adequate support, psychological ability, and adequate information and knowledge. This analysis contributes to the advancement of knowledge in the area of hospital discharge, by proposing an operational definition of readiness for hospital discharge, derived from the literature. A better understanding of the phenomenon will assist healthcare professionals to recognize, measure and implement interventions where necessary, to ensure patients are ready for hospital discharge and assist in the advancement of knowledge for all professionals involved in patient discharge from hospital. © 2017 John Wiley & Sons Ltd.

Design and Evaluation of Nextgen Aircraft Separation Assurance Concepts

Science.gov (United States)

Johnson, Walter; Ho, Nhut; Arutyunov, Vladimir; Laue, John-Luke; Wilmoth, Ian

2012-01-01

To support the development and evaluation of future function allocation concepts for separation assurance systems for the Next Generation Air Transportation System, this paper presents the design and human-in-the-loop evaluation of three feasible function allocation concepts that allocate primary aircraft separation assurance responsibilities and workload to: 1) pilots; 2) air traffic controllers (ATC); and 3) automation. The design of these concepts also included rules of the road, separation assurance burdens for aircraft of different equipage levels, and utilization of advanced weather displays paired with advanced conflict detection and resolution automation. Results of the human-in-the-loop simulation show that: a) all the concepts are robust with respect to weather perturbation; b) concept 1 (pilots) had highest throughput, closest to assigned spacing, and fewest violations of speed and altitude restrictions; c) the energy of the aircraft during the descent phase was better managed in concepts 1 and 2 (pilots and ATC) than in concept 3 (automation), in which the situation awareness of pilots and controllers was lowest, and workload of pilots was highest. The paper also discusses further development of these concepts and their augmentation and integration with future air traffic management tools and systems that are being considered for NextGen.

MENINGKATKAN MINAT BELAJAR BIOLOGI MENGGUNAKAN PEMBELAJARAN CTL (Contextual Teaching and Learning PADA SISWA DI KELAS VII-B MTs NEGERI PURWOKERTO

Directory of Open Access Journals (Sweden)

Teguh Julianto

2010-09-01

Full Text Available Improving Student’s Interest in Biology lesson by using contextual teaching and learning (CLT methods is n action research study which had an aim to improve student’s interest in biology. The indicator of student’s interest covers the student’s diligence in learning process, active in following teaching and learning process, active in doing a task, the facility and the sources of learning. The result of this researched showed that there were an improvement of students learning interest. The percentage result in cycle I was 39.5%, in cycle 2 was 72.67% and in Cycle 3 was 80.92%. The improvement of students learning interests gave a positive effect toward the students achievement. The students learning achievement in cycle 1 I was 39%, in cycle II was 82% and in cycle III was 93%. In conclusion Contextual Teaching and Learning (CLT can improve the students learning interest in Biology at the Second Grade Students of MTs Negeri Purwokerto. Key words : Improving, Student’s learning interest, Contextual Teaching and Learning (CTL

Technological advances in perioperative monitoring: Current concepts and clinical perspectives.

Science.gov (United States)

Chilkoti, Geetanjali; Wadhwa, Rachna; Saxena, Ashok Kumar

2015-01-01

Minimal mandatory monitoring in the perioperative period recommended by Association of Anesthetists of Great Britain and Ireland and American Society of Anesthesiologists are universally acknowledged and has become an integral part of the anesthesia practice. The technologies in perioperative monitoring have advanced, and the availability and clinical applications have multiplied exponentially. Newer monitoring techniques include depth of anesthesia monitoring, goal-directed fluid therapy, transesophageal echocardiography, advanced neurological monitoring, improved alarm system and technological advancement in objective pain assessment. Various factors that need to be considered with the use of improved monitoring techniques are their validation data, patient outcome, safety profile, cost-effectiveness, awareness of the possible adverse events, knowledge of technical principle and ability of the convenient routine handling. In this review, we will discuss the new monitoring techniques in anesthesia, their advantages, deficiencies, limitations, their comparison to the conventional methods and their effect on patient outcome, if any.

Editorial: Advanced learning technologies

Directory of Open Access Journals (Sweden)

Yu-Ju Lan

2012-03-01

Full Text Available Recent rapid development of advanced information technology brings high expectations of its potential to improvement and innovations in learning. This special issue is devoted to using some of the emerging technologies issues related to the topic of education and knowledge sharing, involving several cutting edge research outcomes from recent advancement of learning technologies. Advanced learning technologies are the composition of various related technologies and concepts such as mobile technologies and social media towards learner centered learning. This editorial note provides an overview of relevant issues discussed in this special issue.

PENINGKATAN HASIL BELAJAR MATA PELAJARAN EKONOMI DENGAN PENERAPAN MODEL PEMBELAJARAN CONTEXTUAL TEACHING AND LEARNING (CTL

Directory of Open Access Journals (Sweden)

Nur Alifah Fitriana

2013-02-01

Full Text Available Proses pembelajaran yang variatif akan membantu siswa dalam pemahaman materi pembelajaran yang diberikan oleh guru. Pada sekolah MA Yasis AT-Taqwa Pahesan, model pembelajaran yang digunakan masih menggunakan model pembelajaran yang konvensional. Disini siswa kurang berperan aktif dalam proses belajar mengajar dan siswa akan cenderung merasa bosan. Untuk menyelesaikan masalah tersebut peneliti mencoba menerapkan model pembelajaran Contextual Teaching and Learning (CTLsebagai upaya meningkatkan hasil belajar siswa. Rancangan penelitian ini merupakan penelitian tindakan kelas dengan dua siklus, setiap siklus meliputi perencanaan, pelaksanaan, pengamatan dan refleksi. Hasil penelitian diperoleh nilai rata-rata pada siklus I yaitu 64,58 dengan ketuntasan klasikal 54,16%, sedangkan untuk siklus II nilai rata-ratanya 79,79 dengan ketuntasan klasikal 79,16%. Pada siklus I aktivitas siswa 55,47% dan siklus II menjadi 76,54%. Sedangkan kinerja guru pada siklus I 51,42% dan meningkat disiklus II 91,42%. Abstract ___________________________________________________________________ The learning processwill help studentsvariedin understandinglearning materialsprovided bythe teacher. AtschoolMAYasisAT-Taqwa Pahesan, learning modelused is stillusingconventionallearning models. Here thestudents areactively involved inthe learning processand students willtend to feelbored. To solvethe problem, the researcher tried toapply thelearning modelContextual Teaching andLearning(CTL as an effort toimprove student learning outcomes. The design ofthis studyisaction researchwithtwocycles, each cycleincluding planning, implementation, observationand reflection. The result showedthe average valuein the first cycleis64.58withclassical completeness54.16%, while forthe second cycleaverage value79.79withclassical completeness79.16%. In the first cycleof student activityand55.47% to76.54% the second cycle. While theperformance of teachersin the first cycleincreased51

The IOM report on improving diagnosis: new concepts.

Science.gov (United States)

Graber, Mark L

2015-12-01

The IOM report 'Improving Diagnosis in Health Care' represents a major advance in summarizing the problem of diagnostic error. Three new concepts in the report will be helpful in future efforts to understand and improve the diagnostic process: a new definition of diagnostic error, a new framework for understanding the diagnostic process, and a new concept of the diagnostic 'team'. This paper highlights these new concepts and their relevance to improving diagnosis.

A collection of publications and articles for a light water ultra-safe plant concept

International Nuclear Information System (INIS)

Klevans, E.H.

1988-01-01

This collection contains reports titled: ''The Penn State Ultra-Safe Reactor Concept; '' ''Ultra Safe Nuclear Power; '' ''Use of the Modular Modeling System, in the Design of the Penn State Advanced Light Water Reactor; '' ''Use of the Modular Modeling System in Severe Transient Analysis of Penn State Advanced Light Water Reactor; '' ''PSU Engineers' Reactor Design May Stop a Future TMI; '' and ''The Penn State Advanced Light Water reactor Concept.''

ORNL R and D on advanced small and medium power reactors: selected topics

International Nuclear Information System (INIS)

White, J.D.; Trauger, D.B.

1989-01-01

From 1984-1985, ORNL studied several innovative small and medium power nuclear concepts with respect to viability. Criteria for assessment of market attractiveness were developed and are described here. Using these criteria and descriptions of selected advanced reactor concepts, an assessment of their projected market viability in the time period 2000-2010 was made. All of these selected concepts could be considered as having the potential for meeting the criteria but, in most cases, considerable R and D would be required to reduce uncertainties. This work and later studies of safety and licensing of advanced, passively safe reactor concepts by ORNL are described. The results of these studies are taken into account in most of the current (FY 1989) work at ORNL on advanced reactors. A brief outline of this current work is given. One of the current R and D efforts at ORNL which addresses the operability and safety of advanced reactors is the Advanced Controls Program. Selected topics from this Program are described

ORNL R and D on advanced small and medium power reactors: Selected topics

International Nuclear Information System (INIS)

White, J.D.; Trauger, D.B.

1988-01-01

From 1984-1985, ORNL studied several innovative small and medium power nuclear concepts with respect to viability. Criteria for assessment of market attractiveness were developed and are described here. Using these criteria and descriptions of selected advanced reactor concepts, and assessment of their projected market viability in the time period 2000-2010 was made. All of these selected concepts could be considered as having the potential for meeting the criteria but, in most cases, considerable RandD would be required to reduce uncertainties. This work and later studies of safety and licensing of advanced, passively safe reactor concepts by ORNL are described. The results of these studies are taken into account in most of the current (FY 1989) work at ORNL on advanced reactors. A brief outline of this current work is given. One of the current RandD efforts at ORNL which addresses the operability and safety of advanced reactors is the Advanced Controls Program. Selected topics from this Program are described. 13 refs., 1 fig

Building Integrated Design Practice under the Concept of Sustainable Development

Science.gov (United States)

Liu, Xuexin

2018-03-01

With the continuous development of social economy, people are more demanding for architecture. Some advanced design concepts are gradually applied to the design of buildings. Under the concept of sustainable development, building integration design has also been widely used to promote the rapid development of architectural design. Integrated design concepts and sustainable development concepts play an important role to meet people’s requirements. This article will explore the concept of sustainable development under the concept of integrated architectural design and practice analysis, propose appropriate measures.

Modernization of the Radioisotopes Production Laboratory of the La Reina Nuclear Center in Chile: Incorporating advanced concepts of safety and good manufacturing practices

International Nuclear Information System (INIS)

Lagos Espinoza, Silvia

2014-01-01

A radioisotopes and radiopharmaceuticals production laboratory was established in Chile in the 1960s for research activities. From 1967 until January 2012, it was dedicated to the manufacturing of radioisotopes and radiopharmaceuticals for medical diagnosis and treatment purposes. In 2012, modernization of the facility’s design and technology began as part of the IAEA technical cooperation project, Modernizing the Radioisotopes Production Laboratory of La Reina Nuclear Centre by Incorporating Advanced Concepts of Safety and Good Manufacturing Practices, (CHI4022)

Some advanced concepts of mobile robotics for plant inspection and maintenance

International Nuclear Information System (INIS)

Halme, A.

1994-01-01

The paper introduces two concepts in robotics the feasibility of which are presently being studied for plant inspection/maintenance purposes. One of them is a walking machine platform which utilizes walking on discrete set of points making it possible to feed energy trough legs and/or grip on fixing points when needing strong support or climbing on walls. The other is a robot society concept in which the work is distributed among the member robots of the society. The society has an inner communication system trough which information is spread between the members. The control system of the society takes care of the task coordination and communication between the society and the user. As a special feature energy distribution within the society is considered. The concept is suggested for inspection and cleaning type of work in process equipment area and also inside processes in some cases. (author)

Failure and damage analysis of advanced materials

CERN Document Server

Sadowski, Tomasz

2015-01-01

The papers in this volume present basic concepts and new developments in failure and damage analysis with focus on advanced materials such as composites, laminates, sandwiches and foams, and also new metallic materials. Starting from some mathematical foundations (limit surfaces, symmetry considerations, invariants) new experimental results and their analysis are shown. Finally, new concepts for failure prediction and analysis will be introduced and discussed as well as new methods of failure and damage prediction for advanced metallic and non-metallic materials. Based on experimental results the traditional methods will be revised.

Advanced intelligence and mechanism approach

Institute of Scientific and Technical Information of China (English)

ZHONG Yixin

2007-01-01

Advanced intelligence will feature the intelligence research in next 50 years.An understanding of the concept of advanced intelligence as well as its importance will be provided first,and detailed analysis on an approach,the mechanism approach.suitable to the advanced intelligence research will then be flolowed.And the mutual relationship among mechanism approach,traditional approaches existed in artificial intelligence research,and the cognitive informatics will be discussed.It is interesting to discover that mechanism approach is a good one to the Advanced Intelligence research and a tmified form of the existed approaches to artificial intelligence.

Proof-of-Concept of a Networked Validation Environment for Distributed Air/Ground NextGen Concepts

Science.gov (United States)

Grisham, James; Larson, Natalie; Nelson, Justin; Reed, Joshua; Suggs, Marvin; Underwood, Matthew; Papelis, Yiannis; Ballin, Mark G.

2013-01-01

The National Airspace System (NAS) must be improved to increase capacity, reduce flight delays, and minimize environmental impacts of air travel. NASA has been tasked with aiding the Federal Aviation Administration (FAA) in NAS modernization. Automatic Dependent Surveillance-Broadcast (ADS-B) is an enabling technology that is fundamental to realization of the Next Generation Air Transportation System (NextGen). Despite the 2020 FAA mandate requiring ADS-B Out equipage, airspace users are lacking incentives to equip with the requisite ADS-B avionics. A need exists to validate in flight tests advanced concepts of operation (ConOps) that rely on ADS-B and other data links without requiring costly equipage. A potential solution is presented in this paper. It is possible to emulate future data link capabilities using the existing in-flight Internet and reduced-cost test equipment. To establish proof-of-concept, a high-fidelity traffic operations simulation was modified to include a module that simulated Internet transmission of ADS-B messages. An advanced NASA ConOp, Flight Deck Interval Management (FIM), was used to evaluate technical feasibility. A preliminary assessment of the effects of latency and dropout rate on FIM was performed. Flight hardware that would be used by proposed test environment was connected to the simulation so that data transfer from aircraft systems to test equipment could be verified. The results indicate that the FIM ConOp, and therefore, many other advanced ConOps with equal or lesser response characteristics and data requirements, can be evaluated in flight using the proposed concept.

Advanced Wind Turbine Drivetrain Concepts: Workshop Report, June 29-30, 2010

Energy Technology Data Exchange (ETDEWEB)

DOE, EERE

2010-12-01

This report presents key findings from the Department of Energy's Advanced Drivetrain Workshop, held on June 29-30, 2010 in Broomfield, Colorado, to assess different advanced drivetrain technologies, their relative potential to improve the state-of-the-art in wind turbine drivetrains, and the scope of research and development needed for their commercialization in wind turbine applications.

Advanced number theory

CERN Document Server

Cohn, Harvey

1980-01-01

""A very stimulating book ... in a class by itself."" - American Mathematical MonthlyAdvanced students, mathematicians and number theorists will welcome this stimulating treatment of advanced number theory, which approaches the complex topic of algebraic number theory from a historical standpoint, taking pains to show the reader how concepts, definitions and theories have evolved during the last two centuries. Moreover, the book abounds with numerical examples and more concrete, specific theorems than are found in most contemporary treatments of the subject.The book is divided into three parts

Cost-estimate guidelines for advanced nuclear power technologies

International Nuclear Information System (INIS)

Delene, J.G.; Hudson, C.R.

1993-01-01

Various advanced power plant concepts are currently under development. These include several advanced light water reactors as well as the modular high-temperature gas-cooled reactor and the advanced liquid-metal reactor. One measure-of the attractiveness of a new concept is cost. Invariably, the cost of a new type of power plant will be compared with other alternative forms of electric generation. In order to make reasonable comparative assessments of competing technologies, consistent ground rules and assumptions must be applied when developing cost estimates. This paper describes the cost-estimate guidelines developed by Oak Ridge National Laboratory for the U.S. Department of Energy (DOE) to be used in developing cost estimates for the advanced nuclear reactors and how these guidelines relate to the DOE cost verification process

African Cultural Concept of Death and the Idea of Advance Care Directives.

Science.gov (United States)

Ekore, Rabi Ilemona; Lanre-Abass, Bolatito

2016-01-01

An advance care directive is a person's oral or written instructions about his or her future medical care, if he or she becomes unable to communicate. It may be in written or oral form. Africans ordinarily do not encourage the contemplation of death or any discussion about their own or their loved ones' death. According to the African belief system, life does not end with death, but continues in another realm. Becoming an ancestor after death is a desirable goal of every individual, a feat which cannot be achieved if an individual asks for an unnatural death by attempting to utilize advance care directives. Advance care directives are considered to be too individualistic for communitarian societies such as Africa. Coupled with the communitarian nature of African societies are issues such as lack of awareness of advance directives, fear of death and grief, and the African cultural belief system, which are potential barriers to the utilization of advance care directives in the African setting. Hence, the need for culture sensitivity which makes it imperative that patient's family and loved ones are carried along as far as possible, without compromising the autonomy of the patient in question when utilizing advance care directives.

Advances by the Integral Fast Reactor Program

International Nuclear Information System (INIS)

Lineberry, M.J.; Pedersen, D.R.; Walters, L.C.; Cahalan, J.E.

1991-01-01

The advances by the Integral Fast Reactor Program at Argonne National Laboratory are the subject of this paper. The Integral Fast Reactor (IFR) is an advanced liquid-metal-cooled reactor concept being developed at Argonne National Laboratory. The advances stressed in the paper include fuel irradiation performance, improved passive safety, and the development of a prototype fuel cycle facility. 14 refs

An evolutionary concept analysis of futility in health care.

Science.gov (United States)

Morata, Lauren

2018-06-01

To report a concept analysis of futility in health care. Each member of the healthcare team: the physician, the nurse, the patient, the family and all others involved perceive futility differently. The current evidence and knowledge in regard to futility in health care manifest a plethora of definitions, meanings and interpretations without consensus. Concept analysis. Databases searched included Medline, Cumulative Index of Nursing and Allied Health Literature, Academic Search Premier, Cochrane Database of Systematic Reviews and PsycINFO. Search terms included "futil*," "concept analysis," "concept," "inefficacious," "non-beneficial," "ineffective" and "fruitless" from 1935-2016 to ensure a historical perspective of the concept. A total of 106 articles were retained to develop the concept. Rogers' evolutionary concept analysis was used to evaluate the concept of futility from ancient medicine to the present. Seven antecedents (the patient/family autonomy, surrogate decision-making movement, the patient-family/physician relationship, physician authority, legislation and court rulings, catastrophic events and advancing medical technology) lead to four major attributes (quantitative, physiologic, qualitative, and disease-specific). Ultimately, futile care could lead to consequences such as litigation, advancing technology, increasing healthcare costs, rationing, moral distress and ethical dilemmas. Futility in health care demonstrates components of a cyclical process and a consensus definition is proposed. A framework is developed to clarify the concept and articulate relationships among attributes, antecedents and consequences. Further testing of the proposed definition and framework are needed. © 2018 John Wiley & Sons Ltd.

Promiscuous prediction and conservancy analysis of CTL binding epitopes of HCV 3a viral proteome from Punjab Pakistan: an In Silico Approach

Directory of Open Access Journals (Sweden)

Idrees Muhammad

2011-02-01

Full Text Available Abstract Background HCV is a positive sense RNA virus affecting approximately 180 million people world wide and about 10 million Pakistani populations. HCV genotype 3a is the major cause of infection in Pakistani population. One of the major problems of HCV infection especially in the developing countries that limits the limits the antiviral therapy is the long term treatment, high dosage and side effects. Studies of antigenic epitopes of viral sequences of a specific origin can provide an effective way to overcome the mutation rate and to determine the promiscuous binders to be used for epitope based subunit vaccine design. An in silico approach was applied for the analysis of entire HCV proteome of Pakistani origin, aimed to identify the viral epitopes and their conservancy in HCV genotypes 1, 2 and 3 of diverse origin. Results Immunoinformatic tools were applied for the predictive analysis of HCV 3a antigenic epitopes of Pakistani origin. All the predicted epitopes were then subjected for their conservancy analysis in HCV genotypes 1, 2 and 3 of diverse origin (worldwide. Using freely available web servers, 150 MHC II epitopes were predicted as promiscuous binders against 51 subjected alleles. E2 protein represented the 20% of all the predicted MHC II epitopes. 75.33% of the predicted MHC II epitopes were (77-100% conserve in genotype 3; 47.33% and 40.66% in genotype 1 and 2 respectively. 69 MHC I epitopes were predicted as promiscuous binders against 47 subjected alleles. NS4b represented 26% of all the MHC I predicted epitopes. Significantly higher epitope conservancy was represented by genotype 3 i.e. 78.26% and 21.05% for genotype 1 and 2. Conclusions The study revealed comprehensive catalogue of potential HCV derived CTL epitopes from viral proteome of Pakistan origin. A considerable number of predicted epitopes were found to be conserved in different HCV genotype. However, the number of conserved epitopes in HCV genotype 3 was

Next Generation of Photovoltaics New Concepts

CERN Document Server

Vega, Antonio; López, Antonio

2012-01-01

This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells.

Next generation of photovoltaics. New concepts

Energy Technology Data Exchange (ETDEWEB)

Cristobal Lopez, Ana Belen; Marti Vega, Antonio; Luque Lopez, Antonio (eds.) [Univ. Politecnica de Madrid (Spain). Inst. de Energia Solar E.T.S.I. Telecomunicacion

2012-07-01

This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells. (orig.)

PERBANDINGAN HASIL BELAJAR IPA SEKOLAH DASAR MELALUI PENGGUNAAN PENDEKATAN GUIDED DISCOVERY DAN PENDEKATAN CTL (CONTEXTUAL TEACHING AND LEARNING

Directory of Open Access Journals (Sweden)

Fiky Ernawati

2016-09-01

Full Text Available Abstrak. Penelitian ini bertujuan untuk mengetahui perbandingan hasil belajar pada mata pelajaran IPA setelah menggunakan pendekatan pembelajaran Guided Discovery dengan pendekatan pembelajaran CTL (Contextual Teaching and Learning pada siswa  kelas  IV SD Negeri  3  Kramatwatu.  Metode  penelitian yang digunakan adalah metode kuasi ekpserimen, sedangkan desain penelitian yang digunakan adalah non equivalent control group design. Ada dua kelas dalam penelitian ini, yaitu kelompok eksperimen dan kelompok kontrol. Kelompok eksperimen yaitu siswa  kelas  IV-A  terdiri  dari  35  siswa  yang  diberikan  perlakuan  dengan pendekatan pembelajaran Guided Discovery dan kelas kontrol yaitu siswa kelas IV-B terdiri dari 33 siswa yang diberikan perlakuan pendekatan pembelajaran CTL (Contextual Teaching and Learning. Ada pun teknik pengumpulan data yang dilakukan meliputi tes hasil belajar berupa posttest serta nontes berupa dokumentasi.   Berdasarkan   hasil   penelitian   menunjukkan   bahwa   terdapat perbedaan hasil belajar siswa kelas eksperimen dan siswa kelas kontrol. Hasil belajar IPA siswa kelas eksperimen lebih tinggi daripada hasil belajar IPA siswa kelas kontrol. Rata-rata hasil belajar IPA kelas eksperimen yaitu 76,07 dan kelas kontrol memperoleh rata-rata 69,34. Kata Kunci : Hasil Belajar IPA, Guided Discovery, Contextual Teaching and Learning   Abstract. This research attempts to know the comparison of the results learning on subject’s science  class  after  using  learning  guided  discovery  approach  with  contextual teaching  and  learning  approach  to  their  student’s  grade  4  of  public  school Kramatwatu  7.  Research methodology used  is the method quasi  experiments, while design research used is non equivalent control group design.There are two classes  in  this  research,  namely  experiment  group  and  control  groups.  The experiment group that is a

Advanced energy projects FY 1994 research summaries

International Nuclear Information System (INIS)

1994-09-01

The Division of Advanced Energy Projects (AEP) provides support to explore the feasibility of novel, energy-related concepts that evolve from advances in basic research. These concepts are typically at an early stage of scientific definition and, therefore, are premature for consideration by applied research or technology development programs. The AEP also supports high-risk, exploratory concepts that do not readily fit into a program area but could have several applications that may span scientific disciplines or technical areas. Projects supported by the Division arise from unsolicited ideas and concepts submitted by researchers. The portfolio of projects is dynamic and reflects the broad role of the Department in supporting research and development for improving the Nation's energy outlook. FY 1994 projects include the following topical areas: novel materials for energy technology; renewable and biodegradable materials; exploring uses of new scientific discoveries; alternate pathways to energy efficiency; alternative energy sources; and innovative approaches to waste treatment and reduction. Summaries are given for 66 projects

Graded Alternating-Time Temporal Logic

Science.gov (United States)

Faella, Marco; Napoli, Margherita; Parente, Mimmo

Graded modalities enrich the universal and existential quantifiers with the capability to express the concept of at least k or all but k, for a non-negative integer k. Recently, temporal logics such as μ-calculus and Computational Tree Logic, Ctl, augmented with graded modalities have received attention from the scientific community, both from a theoretical side and from an applicative perspective. Both μ-calculus and Ctl naturally apply as specification languages for closed systems: in this paper, we add graded modalities to the Alternating-time Temporal Logic (Atl) introduced by Alur et al., to study how these modalities may affect specification languages for open systems.

Advanced concepts, analysis approaches and criteria for nuclear piping system design

International Nuclear Information System (INIS)

Tang, H.T.; Tagart, S.W. Jr.; Tang, Y.K.

1992-01-01

Recent research in piping system design and analysis has resulted in advancements on damping values, independent support motion (ISM), static coefficient method, simplified inelastic method and ASME code criteria changes. In the support area, passive type of supports such as energy-absorbing device and gap stopper have been developed. These advancements provide bases for improved and cost-effective design of future nuclear piping systems. (author)

Advanced teleoperation in nuclear applications: consolidated fuel reprocessing program

International Nuclear Information System (INIS)

Hamel, W.R.; Feldman, M.J.; Martin, H.L.

1984-01-01

A new generation of integrated remote maintenance systems is being developed to meet the needs of future nuclear fuel reprocessing at the Oak Ridge National Laboratory. Development activities cover all aspects of an advanced teleoperated maintenance system with particular emphasis on a new force-reflecting servomanipulator concept. The new manipulator, called the advanced servomanipulator, is microprocessor controlled and is designed to achieve force-reflection performance near that of mechanical master/slave manipulators. The advanced servomanipulator uses a gear-drive transmission which permits modularization for remote maintainability (by other advanced servomanipulators) and increases reliability. Human factors analysis has been used to develop an improved man/machine interface concept based upon colographic displays and menu-driven touch screens. Initial test and evaluation of two advanced servomanipulator slave arms and several other development components have begun. 9 references, 5 figures

Proceedings of the International Symposium on Dynamics of Fluids in Fractured Rocks: Concepts and Recent Advances

Energy Technology Data Exchange (ETDEWEB)

Faybishenko, B. (ed.)

1999-02-01

This publication contains extended abstracts of papers presented at the International Symposium ''Dynamics of Fluids in Fractured Rocks: Concepts and Recent Advances'' held at Ernest Orlando Lawrence Berkeley National Laboratory on February 10-12, 1999. This Symposium is organized in Honor of the 80th Birthday of Paul A. Witherspoon, who initiated some of the early investigations on flow and transport in fractured rocks at the University of California, Berkeley, and at Lawrence Berkeley National Laboratory. He is a key figure in the development of basic concepts, modeling, and field measurements of fluid flow and contaminant transport in fractured rock systems. The technical problems of assessing fluid flow, radionuclide transport, site characterization, modeling, and performance assessment in fractured rocks remain the most challenging aspects of subsurface flow and transport investigations. An understanding of these important aspects of hydrogeology is needed to assess disposal of nu clear wastes, development of geothermal resources, production of oil and gas resources, and remediation of contaminated sites. These Proceedings of more than 100 papers from 12 countries discuss recent scientific and practical developments and the status of our understanding of fluid flow and radionuclide transport in fractured rocks. The main topics of the papers are: Theoretical studies of fluid flow in fractured rocks; Multi-phase flow and reactive chemical transport in fractured rocks; Fracture/matrix interactions; Hydrogeological and transport testing; Fracture flow models; Vadose zone studies; Isotopic studies of flow in fractured systems; Fractures in geothermal systems; Remediation and colloid transport in fractured systems; and Nuclear waste disposal in fractured rocks.

Validation of a Computational Model for the SLS Core Stage Oxygen Tank Diffuser Concept and the Low Profile Diffuser - An Advanced Development Design for the SLS

Science.gov (United States)

Brodnick, Jacob; Richardson, Brian; Ramachandran, Narayanan

2015-01-01

The Low Profile Diffuser (LPD) project originated as an award from the Marshall Space Flight Center (MSFC) Advanced Development (ADO) office to the Main Propulsion Systems Branch (ER22). The task was created to develop and test an LPD concept that could produce comparable performance to a larger, traditionally designed, ullage gas diffuser while occupying a smaller volume envelope. Historically, ullage gas diffusers have been large, bulky devices that occupy a significant portion of the propellant tank, decreasing the tank volume available for propellant. Ullage pressurization of spacecraft propellant tanks is required to prevent boil-off of cryogenic propellants and to provide a positive pressure for propellant extraction. To achieve this, ullage gas diffusers must slow hot, high-pressure gas entering a propellant tank from supersonic speeds to only a few meters per second. Decreasing the incoming gas velocity is typically accomplished through expansion to larger areas within the diffuser which has traditionally led to large diffuser lengths. The Fluid Dynamics Branch (ER42) developed and applied advanced Computational Fluid Dynamics (CFD) analysis methods in order to mature the LPD design from and initial concept to an optimized test prototype and to provide extremely accurate pre-test predictions of diffuser performance. Additionally, the diffuser concept for the Core Stage of the Space Launch System (SLS) was analyzed in a short amount of time to guide test data collection efforts of the qualification of the device. CFD analysis of the SLS diffuser design provided new insights into the functioning of the device and was qualitatively validated against hot wire anemometry of the exterior flow field. Rigorous data analysis of the measurements was performed on static and dynamic pressure data, data from two microphones, accelerometers and hot wire anemometry with automated traverse. Feasibility of the LPD concept and validation of the computational model were

Progress in development of the advanced Thomson scattering diagnostics

International Nuclear Information System (INIS)

Hatae, T; Naito, O; Howard, J; Ebizuka, N; Yoshida, H; Nakatsuka, M; Fujita, H; Kajita, S; Narihara, K; Yamada, I; Funaba, H; Hirano, Y; Koguchi, H

2010-01-01

We have been studied the advanced Thomson scattering diagnostics from viewpoints of new concepts, laser technology and spectrum analysis. This paper summarizes results of development on technologies for advanced Thomson scattering diagnostics.

A Los Alamos concept for accelerator transmutation of waste and energy production (ATW)

International Nuclear Information System (INIS)

1990-01-01

This document contains the diagrams presented at the ATW (Accelerator Transmutation of Waste and Energy Production) External Review, December 10-12, 1990, held at Los Alamos National Laboratory. Included are the charge to the committee and the presentations for the committee's review. Topics of the presentations included an overview of the concept, LINAC technology, near-term application -- high-level defense wastes (intense thermal neutron source, chemistry and materials), advanced application of the ATW concept -- fission energy without a high-level waste stream (overview, advanced technology, and advanced chemistry), and a summary of the research issues

The conception of the individual in non-cooperative game theory

NARCIS (Netherlands)

Davis, J.B.

2003-01-01

This paper examines the conception of individuals as being of certain types in Harsanyi's transformation of games of incomplete information into games of complete information. It argues that while the conception of the individual in games of complete information offers potential advances over the

Towards Technological Approaches for Concept Maps Mining from Text

OpenAIRE

Camila Zacche Aguiar; Davidson Cury; Amal Zouaq

2018-01-01

Concept maps are resources for the representation and construction of knowledge. They allow showing, through concepts and relationships, how knowledge about a subject is organized. Technological advances have boosted the development of approaches for the automatic construction of a concept map, to facilitate and provide the benefits of that resource more broadly. Due to the need to better identify and analyze the functionalities and characteristics of those approaches, we conducted a detailed...

Just-in-time classifiers for recurrent concepts.

Science.gov (United States)

Alippi, Cesare; Boracchi, Giacomo; Roveri, Manuel

2013-04-01

Just-in-time (JIT) classifiers operate in evolving environments by classifying instances and reacting to concept drift. In stationary conditions, a JIT classifier improves its accuracy over time by exploiting additional supervised information coming from the field. In nonstationary conditions, however, the classifier reacts as soon as concept drift is detected; the current classification setup is discarded and a suitable one activated to keep the accuracy high. We present a novel generation of JIT classifiers able to deal with recurrent concept drift by means of a practical formalization of the concept representation and the definition of a set of operators working on such representations. The concept-drift detection activity, which is crucial in promptly reacting to changes exactly when needed, is advanced by considering change-detection tests monitoring both inputs and classes distributions.

An Overview of Advanced Concepts for Near-Space Systems

Science.gov (United States)

2009-06-30

2005). 39 T. R. Knowles, Levitation of a small carbon by visible light, 12th Annual Advanced Space Propulsion Workshop (2001). 40 http...372, 1948. 45 Woodward, J. and Mahood, T., “Gravity, Inertia, and Quantum Vacuum Zero Point Energy Fields,” Foundations of Physics, Vol. 31, No. 5, pp

OPTIMIZATION OF ADVANCED FILTER SYSTEMS

Energy Technology Data Exchange (ETDEWEB)

R.A. Newby; G.J. Bruck; M.A. Alvin; T.E. Lippert

1998-04-30

Reliable, maintainable and cost effective hot gas particulate filter technology is critical to the successful commercialization of advanced, coal-fired power generation technologies, such as IGCC and PFBC. In pilot plant testing, the operating reliability of hot gas particulate filters have been periodically compromised by process issues, such as process upsets and difficult ash cake behavior (ash bridging and sintering), and by design issues, such as cantilevered filter elements damaged by ash bridging, or excessively close packing of filtering surfaces resulting in unacceptable pressure drop or filtering surface plugging. This test experience has focused the issues and has helped to define advanced hot gas filter design concepts that offer higher reliability. Westinghouse has identified two advanced ceramic barrier filter concepts that are configured to minimize the possibility of ash bridge formation and to be robust against ash bridges should they occur. The ''inverted candle filter system'' uses arrays of thin-walled, ceramic candle-type filter elements with inside-surface filtering, and contains the filter elements in metal enclosures for complete separation from ash bridges. The ''sheet filter system'' uses ceramic, flat plate filter elements supported from vertical pipe-header arrays that provide geometry that avoids the buildup of ash bridges and allows free fall of the back-pulse released filter cake. The Optimization of Advanced Filter Systems program is being conducted to evaluate these two advanced designs and to ultimately demonstrate one of the concepts in pilot scale. In the Base Contract program, the subject of this report, Westinghouse has developed conceptual designs of the two advanced ceramic barrier filter systems to assess their performance, availability and cost potential, and to identify technical issues that may hinder the commercialization of the technologies. A plan for the Option I, bench

Navigation concepts for MR image-guided interventions.

Science.gov (United States)

Moche, Michael; Trampel, Robert; Kahn, Thomas; Busse, Harald

2008-02-01

The ongoing development of powerful magnetic resonance imaging techniques also allows for advanced possibilities to guide and control minimally invasive interventions. Various navigation concepts have been described for practically all regions of the body. The specific advantages and limitations of these concepts largely depend on the magnet design of the MR scanner and the interventional environment. Open MR scanners involve minimal patient transfer, which improves the interventional workflow and reduces the need for coregistration, ie, the mapping of spatial coordinates between imaging and intervention position. Most diagnostic scanners, in contrast, do not allow the physician to guide his instrument inside the magnet and, consequently, the patient needs to be moved out of the bore. Although adequate coregistration and navigation concepts for closed-bore scanners are technically more challenging, many developments are driven by the well-known capabilities of high-field systems and their better economic value. Advanced concepts such as multimodal overlays, augmented reality displays, and robotic assistance devices are still in their infancy but might propel the use of intraoperative navigation. The goal of this work is to give an update on MRI-based navigation and related techniques and to briefly discuss the clinical experience and limitations of some selected systems. (Copyright) 2008 Wiley-Liss, Inc.

Defence-in-depth concept for the EU-ABWR

Energy Technology Data Exchange (ETDEWEB)

Yamazaki, Hiroshi; Fuchs, Steffen; Takada, Toshiaki; Kataoka, Kazuyoshi [Toshiba International Limited (Japan)

2013-07-01

The current defence-in-depth (DiD) concept has been established by the Reactor Harmonization Working Group (RHWG) of Western European Nuclear Regulators Association (WENRA). Principally the DiD concept was already part of the very early power reactor designs. However, additional considerations have been done in order to take plant conditions into account which are beyond the original design basis. The most recent advancements have been done based on major lessons learned from the Fukushima Dai-Ichi accident. Especially for new nuclear reactors it has to be demonstrated that DiD aspects have been considered in their design. Currently Toshiba is adapting its Advanced Boiling Water Reactor (ABWR) for the European market, at first in Finland. This presentation aims to describe how the new DiD concept has been applied to achieve the safety goals for a modern reactor type and to ensure a design that can be licensed in Western Europe. (orig.)

A program to develop advanced EBT [ELMO Bumpy Torus] concepts and international collaboration on the Bumpy Torus concept: Final report

International Nuclear Information System (INIS)

1987-01-01

This project was undertaken to develop innovative concepts for improving the performance of ELMO Bumpy Torus devices in those aspects of plasma confinement that are particularly relevant to an eventual EBT reactor concept. These include effective magnetic utilization using Andreoletti coils, enhanced confinement using positive ambipolar potentials, and attractive divertor concepts that are compatible with formation and maintenance of ELMO rings. Each of the three major objectives was achieved and, except for the divertor studies, documented for publication and presentation at major scientific meetings. This report provides a brief recapitulation of the major results achieved in the form of a collection of those publications, together with this Introduction

An integral reactor design concept for a nuclear co-generation plant

International Nuclear Information System (INIS)

Lee, D.J.; Kim, J.I.; Kim, K.K.; Chang, M.H.; Moon, K.S.

1997-01-01

An integral reactor concept for nuclear cogeneration plant is being developed at KAERI as an attempt to expand the peaceful utilization of well established commercial nuclear technology, and related industrial infrastructure such as desalination technology in Korea. Advanced technologies such as intrinsic and passive safety features are implemented in establishing the design concepts to enhance the safety and performance. Research and development including laboratory-scale tests are concurrently underway to evaluate the characteristics of various passive safety concepts and provide the proper technical data for the conceptual design. This paper describes the preliminary safety and design concepts of the advanced integral reactor. Salient features of the design are hexagonal core geometry, once-through helical steam generator, self-pressurizer, and seismic resistant fine control CEDMS, passive residual heat removal system, steam injector driven passive containment cooling system. (author)

Advanced programming concepts in a course on grammars and parsing

NARCIS (Netherlands)

Jeuring, J.T.; Swierstra, S.D.

1999-01-01

One of the important goals of the Computer Science curriculum at Utrecht University is to familiarize students with abstract programming concepts such as, for example, partial evaluation and deforestation. A course on grammars and parsing offers excellent possibilities for exemplifying and

Knowledge based systems advanced concepts, techniques and applications

CERN Document Server

1997-01-01

The field of knowledge-based systems (KBS) has expanded enormously during the last years, and many important techniques and tools are currently available. Applications of KBS range from medicine to engineering and aerospace.This book provides a selected set of state-of-the-art contributions that present advanced techniques, tools and applications. These contributions have been prepared by a group of eminent researchers and professionals in the field.The theoretical topics covered include: knowledge acquisition, machine learning, genetic algorithms, knowledge management and processing under unc

Advanced nuclear reactor and nuclear fusion power generation

International Nuclear Information System (INIS)

2000-04-01

This book comprised of two issues. The first one is a advanced nuclear reactor which describes nuclear fuel cycle and advanced nuclear reactor like liquid-metal reactor, advanced converter, HTR and extra advanced nuclear reactors. The second one is nuclear fusion for generation energy, which explains practical conditions for nuclear fusion, principle of multiple magnetic field, current situation of research on nuclear fusion, conception for nuclear fusion reactor and economics on nuclear fusion reactor.

Advanced energy projects FY 1992 research summaries

International Nuclear Information System (INIS)

1992-09-01

The Division of Advanced Energy Projects (AEP) provides support to explore the feasibility of novel, energy-related concepts that evolve from advances in basic research. These concepts are typically at an early stage of scientific definition and, therefore, are beyond the scope of ongoing applied research or technology development programs. The Division provides a mechanism for converting basic research findings to applications that eventually could impact the Nation's energy economy. Technical topics include physical, chemical, materials, engineering, and biotechnologies. Projects can involve interdisciplinary approaches to solve energy-related problems. Projects are supported for a finite period of time, which is typically three years. Annual funding levels for projects are usually about $300,000 but can vary from approximately $50,000 to $500,000. It is expected that, following AEP support, each concept will be sufficiently developed and promising to attract further funding from other sources in order to realize its full potential. There were 39 research projects in the Division of Advanced Energy Projects during Fiscal Year 1992 (October 1, 1991 -- September 30, 1992). The abstracts of those projects are provided to introduce the overall program in Advanced Energy Projects. Further information on a specific project may be obtained by contacting the principal investigator, who is listed below the project title. Projects completed during FY 1992 are indicated

Recent Advances in Airframe-Propulsion Concepts with Distributed Propulsion

OpenAIRE

Isikveren , A.T.; Seitz , A.; Bijewitz , J.; Hornung , M.; Mirzoyan , A.; Isyanov , A.; Godard , J.L.; Stückl , S.; Van Toor , J.

2014-01-01

International audience; This paper discusses design and integration associated with distributed propulsion as a means of providing motive power for future aircraft concepts. The technical work reflects activities performed within a European Commission funded Framework 7 project entitled Distributed Propulsion and Ultra-high By-Pass Rotor Study at Aircraft Level, or, DisPURSAL. In this instance, the approach of distributed propulsion includes one unique solution that integrates the fuselage wi...

Advanced plutonium assembly (apa): evolution of the concept, neutron and thermal-mechanic constraints

International Nuclear Information System (INIS)

Porta, J.; Gastaldi, B.; Krakowiak-Aillaud, C.; Buffe, L.

2002-01-01

The APA concept was developed with the aim of increasing the PWR capacity to burn plutonium emerging from the recycling of irradiated fuels in the French park of nuclear power plants. At first, a concept using annular pins was optimised to allow a good consumption of plutonium while preserving an acceptable neutron control. To cope with the technological problems and those posed by the manufacture of these annular pins, an alternative concept is presented here. It poses as initial conditions the conservation of both the plutonium balance and the respect of the reactivity control. (authors)

Accuracy Improvement Capability of Advanced Projectile Based on Course Correction Fuze Concept

OpenAIRE

Elsaadany, Ahmed; Wen-jun, Yi

2014-01-01

Improvement in terminal accuracy is an important objective for future artillery projectiles. Generally it is often associated with range extension. Various concepts and modifications are proposed to correct the range and drift of artillery projectile like course correction fuze. The course correction fuze concepts could provide an attractive and cost-effective solution for munitions accuracy improvement. In this paper, the trajectory correction has been obtained using two kinds of course corr...

Lifelong learning and advancement in a company: Experience from Serbia

Directory of Open Access Journals (Sweden)

Mllutinović Olivera

2014-01-01

Full Text Available Lifelong learning concept is the concept that brings humanism in both everyday and business life of people. It promotes education, learning, cooperation and advancement in people's lives. During last two decades it became obvious that it is important to implement this concept, particularly in the field of economy in order to achieve better economic results. The aim of this paper is to find out if there is an actual implementation of lifelong learning concept in Serbia. Besides that it will also show if there are instances of advancement for employees in the companies that are implementing lifelong learning concept. The paper contains empirical research that was conducted in 15 companies in Serbia, primarily state-owned. This research gathered the opinion of 492 individuals, both female and male, with every type of education possible in Serbia. By analyzing the given results, the authors of this paper will give a proposal for future improved implementation of lifelong learning concept in Serbia.

Advanced calculus of a single variable

CERN Document Server

Geveci, Tunc

2016-01-01

This advanced undergraduate textbook is based on a one-semester course on single variable calculus that the author has been teaching at San Diego State University for many years. The aim of this classroom-tested book is to deliver a rigorous discussion of the concepts and theorems that are dealt with informally in the first two semesters of a beginning calculus course. As such, students are expected to gain a deeper understanding of the fundamental concepts of calculus, such as limits (with an emphasis on ε-δ definitions), continuity (including an appreciation of the difference between mere pointwise and uniform continuity), the derivative (with rigorous proofs of various versions of L’Hôpital’s rule) and the Riemann integral (discussing improper integrals in-depth, including the comparison and Dirichlet tests). Success in this course is expected to prepare students for more advanced courses in real and complex analysis and this book will help to accomplish this. The first semester of advanced calculus...

Advances and New Concepts in Alcohol-Induced Organelle Stress, Unfolded Protein Responses and Organ Damage

Directory of Open Access Journals (Sweden)

Cheng Ji

2015-06-01

Full Text Available Alcohol is a simple and consumable biomolecule yet its excessive consumption disturbs numerous biological pathways damaging nearly all organs of the human body. One of the essential biological processes affected by the harmful effects of alcohol is proteostasis, which regulates the balance between biogenesis and turnover of proteins within and outside the cell. A significant amount of published evidence indicates that alcohol and its metabolites directly or indirectly interfere with protein homeostasis in the endoplasmic reticulum (ER causing an accumulation of unfolded or misfolded proteins, which triggers the unfolded protein response (UPR leading to either restoration of homeostasis or cell death, inflammation and other pathologies under severe and chronic alcohol conditions. The UPR senses the abnormal protein accumulation and activates transcription factors that regulate nuclear transcription of genes related to ER function. Similarly, this kind of protein stress response can occur in other cellular organelles, which is an evolving field of interest. Here, I review recent advances in the alcohol-induced ER stress response as well as discuss new concepts on alcohol-induced mitochondrial, Golgi and lysosomal stress responses and injuries.

Advanced IGCC-Hypogen concepts for a developing hydrogen market

Energy Technology Data Exchange (ETDEWEB)

Starr, F.; Cormos, C.-C.; Tzimas, E.; Brown, A. [European Commission, Petten (Netherlands). DG Joint Research Centre, Institute for Energy

2007-07-01

With FP6 the EU is funding a project called 'Dynamis' which aims to design plants to generate electricity, plus a limited amount of hydrogen from fossil fuels, in which the CO{sub 2} is captured and stored underground. Such plants have been characterised as being of the 'HYPOGEN' type since they generate both hydrogen and electric power. As the hydrogen market develops IGCC-Hypogen based systems will need to produce much greater amounts of hydrogen. It is also desirable that such plants should be able to vary the proportion of hydrogen-to-electricity. This will enable IGCC-Hypogen plants to load follow and two-shift as electricity demand from the grid changes. Such variations in power output are not always practical with existing designs of electricity-only IGCCs. This paper reviews the technical issues involved in providing a high-flexibility IGCC-Hypogen plant. Three such concepts are discussed (1) very limited flexibility in which the changes from a fixed hydrogen-electricity ratio concept are minor, (2) moderate level of flexibility in which the limit is imposed by the CCGT gas turbine turndown (3) complete flexibility, the plant being able produce the energy as all-electricity or all-hydrogen. 9 refs., 2 figs., 1 tab.

Difficulties of learning probability concepts, the reasons why these concepts cannot be learned and suggestions for solution

Directory of Open Access Journals (Sweden)

Dilek Sezgin MEMNUN

2008-06-01

Full Text Available Probability holds the first place among the subjects that both teachers and students have difficulty in handling. Although probability has an important role in many professions and a great many decisions we make for our daily lives, the understanding of the probability concepts is not an easy ability to gain for many students. Most of the students develop perception about lots of probability concepts and they have difficulty finding a reason for probability events. Thus, in the present study, the difficulties faced while learning probability concepts and the reasons why these concepts cannot be learned well are investigated, these reasons are tried to be put forward, and some suggestions for solutions regarding these concepts are presented. In this study, cross-hatching model was used. National and international studies on the subject of probability are investigated, the reasons why these concepts cannot be learned were categorized in the light of findings obtained, and the reasons why these concepts cannot be learned and taught are tried to be discovered. The categorization was displayed with Ishikawa diagram. In the diagram, the reasons why these concepts cannot be learned were noted as six categories. These categories were age, the insufficiency of advanced information, the deficiency of argumentation ability, teacher, error in concept, and students’ negative attitudes.

A nuclear powered pulsed inductive plasma accelerator as a viable propulsion concept for advanced OTV space applications

International Nuclear Information System (INIS)

Tapper, M.L.

1982-01-01

An electric propulsion concept suitable for delivering heavy payloads from low earth orbit (LEO) to high energy earth orbit is proposed. The system consists of a number of pulsed inductive plasma thrusters powered by a 100 kWe space nuclear power system. The pulsed plasma thruster is a relatively simple electrodeless device. It also exhibits adequate conversion to thrust power in the desired I sub sp regime of 1500 to 3000 seconds for optimal payload transfer from low earth to high earth orbit. Because of these features and the fact that the nuclear power unit will be capable of delivering sustained high power levels throughout the duration of any given mission, the system presented appears to be a very promising propulsion candidate for advanced orbital transfer vehicle (OTV) applications. An OTV, which makes use of this propulsion system and which has been designed to lift a 9000-lb payload into geosynchronous earth orbit, (GEO) is also examined

Advanced handling-systems with enhanced performance flexibility

International Nuclear Information System (INIS)

1986-04-01

This report describes the results of a project related to future applications and requirements for advanced handling systems. This report consists of six chapters. Following the description of the aims the tools for setting up the requirements for the handling systems including the experience during the data acquisition process is described. Furthermore some information is given about the current state of the art of robotics and manipulators. Of paramount importance are the descriptions of applications and related concepts in the following chapters leading to specific categories of advanced handling units. The paper closes with the description of the first concepts for realization. (orig./HP) [de

Advanced Automotive Diesel Assessment Program, executive summary

Science.gov (United States)

1983-01-01

The objectives of this analytical study were: to select one advanced automotive diesel engine (AAD) concept which would increase the tank mileage of a 3,000 pound passenger car from the present 35 mpg to at least 52 mpg; to identify long term component research and development work required to bring the selected concept to fruition; and to prepare a development strategy that will bring the selected concept to a prototype testing phase. Cummins Engine Company has completed this study. The selected concept is a 4 stroke cycle, direct injection, spark assisted, advanced adiabatic diesel engine with positive displacement compounding plus expander and part load air preheating. The engine does not use a liquid coolant nor liquid lubricants. It is a 4 cylinder, in-line, 77 mm bore x 77 mm stroke, 1.434 liters displacement engine weighing 300 lb, and rated at 70 BHP at 3000 rpm. Installation dimensions are 621 mm length x 589 mm width x 479 mm height (24.4 inch x 22 inch x 18.9 inch).

Cardiopulmonary resuscitation: update, controversies and new advances

Directory of Open Access Journals (Sweden)

Alexandre C. Zago

1999-03-01

Full Text Available Cardiopulmonary arrest is a medical emergency in which the lapse of time between event onset and the initiation of measures of basic and advanced support, as well as the correct care based on specific protocols for each clinical situation, constitute decisive factors for a successful therapy. Cardiopulmonary arrest care cannot be restricted to the hospital setting because of its fulminant nature. This necessitates the creation of new concepts, strategies and structures, such as the concept of life chain, cardio-pulmonary resuscitation courses for professionals who work in emergency medical services, the automated external defibrillator, the implantable cardioverter-defibrillator, and mobile intensive care units, among others. New concepts, strategies and structures motivated by new advances have also modified the treatment and improved the results of cardiopulmonary resuscitation in the hospital setting. Among them, we can cite the concept of cerebral resuscitation, the application of the life chain, the creation of the universal life support algorithm, the adjustment of drug doses, new techniques - measure of the end-tidal carbon dioxide levels and of the coronary perfusion pressure - and new drugs under research.

Systemization of Design and Analysis Technology for Advanced Reactor

International Nuclear Information System (INIS)

Kim, Keung Koo; Lee, J.; Zee, S. K.

2009-01-01

The present study is performed to establish the base for the license application of the original technology by systemization and enhancement of the technology that is indispensable for the design and analysis of the advanced reactors including integral reactors. Technical reports and topical reports are prepared for this purpose on some important design/analysis methodology; design and analysis computer programs, structural integrity evaluation of main components and structures, digital I and C systems and man-machine interface design. PPS design concept is complemented reflecting typical safety analysis results. And test plans and requirements are developed for the verification of the advanced reactor technology. Moreover, studies are performed to draw up plans to apply to current or advanced power reactors the original technologies or base technologies such as patents, computer programs, test results, design concepts of the systems and components of the advanced reactors. Finally, pending issues are studied of the advanced reactors to improve the economics and technology realization

Research and development on the application of advanced control technologies to advanced nuclear reactor systems: A US national perspective

International Nuclear Information System (INIS)

White, J.D.; Monson, L.R.; Carrol, D.G.; Dayal, Y.

1989-01-01

Control system designs for nuclear power plants are becoming more advanced through the use of digital technology and automation. This evolution is taking place because of: (1) the limitations in analog based control system performance and maintenance and availability and (2) the promise of significant improvement in plant operation and availability due to advances in digital and other control technologies. Digital retrofits of control systems in US nuclear plants are occurring now. Designs of control and protection systems for advanced LWRs are based on digital technology. The use of small inexpensive, fast, large-capacity computers in these designs is the first step of an evolutionary process described in this paper. Under the sponsorship of the US Department of Energy (DOE), Oak Ridge National Laboratory, Argonne National Laboratory, GE Nuclear Energy and several universities are performing research and development in the application of advances in control theory, software engineering, advanced computer architectures, artificial intelligence, and man-machine interface analysis to control system design. The target plant concept for the work described in this paper is the Power Reactor Inherently Safe Module reactor (PRISM), an advanced modular liquid metal reactor concept. This and other reactor designs which provide strong passive responses to operational upsets or accidents afford good opportunities to apply these advances in control technology. 18 refs., 5 figs

Advanced concepts in particle and field theory

CERN Document Server

Hübsch, Tristan

2015-01-01

Uniting the usually distinct areas of particle physics and quantum field theory, gravity and general relativity, this expansive and comprehensive textbook of fundamental and theoretical physics describes the quest to consolidate the basic building blocks of nature, by journeying through contemporary discoveries in the field, and analysing elementary particles and their interactions. Designed for advanced undergraduates and graduate students and abounding in worked examples and detailed derivations, as well as including historical anecdotes and philosophical and methodological perspectives, this textbook provides students with a unified understanding of all matter at the fundamental level. Topics range from gauge principles, particle decay and scattering cross-sections, the Higgs mechanism and mass generation, to spacetime geometries and supersymmetry. By combining historically separate areas of study and presenting them in a logically consistent manner, students will appreciate the underlying similarities and...

Advances in nuclear science and technology

CERN Document Server

Greebler, Paul

1968-01-01

Advances in Nuclear Science and Technology Volume 4 provides information pertinent to the fundamental aspects of advanced reactor concepts. This book discusses the advances in various areas of general applicability, including modern perturbation theory, optimal control theory, and industrial application of ionizing radiations.Organized into seven chapters, this volume begins with an overview of the technology of sodium-cooled fast breeder power reactors and gas-cooled power reactors. This text then examines the key role of reactor safety in the development of fast breeder reactors. Other chapt

Thoracic endometriosis syndrome: Current concept in ...

African Journals Online (AJOL)

Background: Thoracic endometriosis is a rare pathology. The diagnosis is often delayed or missed, however recently, there has been significant advances in the knowledge of this condition and hence, an improvement in the diagnosis and treatment. Objective: To review the current concepts in the pathophysiology and ...

Emotional intelligence in professional nursing practice: A concept review using Rodgers's evolutionary analysis approach

Directory of Open Access Journals (Sweden)

Angelina E. Raghubir

2018-04-01

Full Text Available Background: Knowledge around emotional intelligence originated in the 1990s from research regarding thoughts, emotions and abilities. The concept of emotional intelligence has evolved over the last 25 years; however, the understanding and use is still unclear. Despite this, emotional intelligence has been a widely-considered concept within professions such as business, management, education, and within the last 10 years has gained traction within nursing practice. Aims and objectives: The aim of this concept review is to clarify the understanding of the concept emotional intelligence, what attributes signify emotional intelligence, what are its antecedents, consequences, related terms and implications to advance nursing practice. Method: A computerized search was guided by Rodger's evolutional concept analysis. Data courses included: CINAHL, PyschINFO, Scopus, EMBASE and ProQuest, focusing on articles published in Canada and the United Stated during 1990–2017. Results: A total of 23 articles from various bodies of disciplines were included in this integrative concept review. The analysis reveals that there are many inconsistencies regarding the description of emotional intelligence, however, four common attributes were discovered: self-awareness, self-management, social awareness and social/relationship management. These attributes facilitate the emotional well-being among advance practice nurses and enhances the ability to practice in a way that will benefit patients, families, colleagues and advance practice nurses as working professionals and as individuals. Conclusion: The integration of emotional intelligence is supported within several disciplines as there is consensus on the impact that emotional intelligence has on job satisfaction, stress level, burnout and helps to facilitate a positive environment. Explicit to advance practice nursing, emotional intelligence is a concept that may be central to nursing practice as it has the

Conceptual design of ICF reactor SENRI, Part II. Advances in design and pellet gain scaling

International Nuclear Information System (INIS)

Ido, S.; Mima, K.; Nakai, S.; Tsuji, R.; Yamanaka, C.

1984-01-01

This chapter reviews the recent design studies on reactor concepts with magnetically guided lithium flow, SENRI-I, SENRI-IA and SENRI-II. The routes from the present status to power reactors and an advanced fuel pellet concept is also discussed. Topics covered include pellet design, magnetohydrodynamic design of liquid lithium flow; reactor cavity concepts with magnetically guided lithium flow, a thermo-hydraulic analysis, a tritium recovery system; and an advanced fuel pellet concept for an inertial confinement fusion (ICF) reactor without a tritium breeding blanket. An advanced fuel pellet for an ICF reactor without a T breeder was studied in the model calculations, which showed sufficiently high values of pellet gain. Includes a table and 8 diagrams

Advanced converter technology. Technical progress report, May 23, 1979-May 22, 1980

Energy Technology Data Exchange (ETDEWEB)

Banic, C. V.; Eckhouse, S. A.; Kornbrust, F. J.; Lipman, K.; Peterson, J. L.; Rosati, R. W.

1980-01-01

The overall objective of this program is to define an advanced converter system employing 1980's technology in all subsystem and component areas for use in electrochemical energy storage systems. Additional experimental effort will validate elements of the advanced commutation circuitry on a full-scale breadboard basis. Improved models of battery electrical characteristics are beng defined and experimental apparatus is being designed to measure these characteristics and to enable better definition of the battery-power conditioner interface. Improvement of energy-storage system performance through modification of battery converter characteristics will also be investigated. During this first year of the contract, a new more advanced concept for power conditioning based on a concept defined by United Technologies Corporation for fuel cell use was evaluated. This high switching frequency concept has the potential for significantly reducing the size and cost of battery plant power conditioners. As a result, the Department of Energy authorized redirection of the program to first evaluate this new concept and then to reorient the program to adopt this concept as the primary one. Progress is reported. (WHK)

Partitioning in P-T concept

International Nuclear Information System (INIS)

Zhang Peilu; Qi Zhanshun; Zhu Zhixuan

2000-01-01

Comparison of dry- and water-method for partitioning fission products and minor actinides from the spent fuels, and description of advance of dry-method were done. Partitioning process, some typical concept and some results of dry-method were described. The problems fond in dry-method up to now were pointed out. The partitioning study program was suggested

Alternative Conceptions: Turning Adversity into Advantage

Science.gov (United States)

Ferreira, Annalize; Lemmer, Miriam; Gunstone, Richard

2017-08-01

While a vast body of research has identified difficulties in students' understanding about forces and acceleration and their related alternative conceptions, far less research suggests ways to use students' alternative conceptions to enhance conceptual understanding of a specific fundamental concept. This study focused on distinguishing between students' conceptual understanding of the Newtonian concept of gravitational acceleration being the same for all objects and students' alternative conception that heavy objects fall faster. A multiple choice questionnaire was distributed to first year physics students for three consecutive years at a university in South Africa. The results indicate that changing the direction of motion and the physics quantity asked in paired questions revealed practically significant inconsistencies in students' reasoning and conceptions. This research contributes to the body of knowledge in proposing how the alternative conception of mass-related gravitational acceleration can be used in instruction to enhance conceptual understanding of the force-mass-acceleration relationship. Understanding of this relationship not only promotes conceptual understanding of the basic Newtonian concepts of the laws of motion which forms the critical foundation on which more advanced physics courses are built, but also contributes towards students' perception of physics as a set of coherent ideas applicable in all contexts.

A HUMAN AUTOMATION INTERACTION CONCEPT FOR A SMALL MODULAR REACTOR CONTROL ROOM

Energy Technology Data Exchange (ETDEWEB)

Le Blanc, Katya; Spielman, Zach; Hill, Rachael

2017-06-01

Many advanced nuclear power plant (NPP) designs incorporate higher degrees of automation than the existing fleet of NPPs. Automation is being introduced or proposed in NPPs through a wide variety of systems and technologies, such as advanced displays, computer-based procedures, advanced alarm systems, and computerized operator support systems. Additionally, many new reactor concepts, both full scale and small modular reactors, are proposing increased automation and reduced staffing as part of their concept of operations. However, research consistently finds that there is a fundamental tradeoff between system performance with increased automation and reduced human performance. There is a need to address the question of how to achieve high performance and efficiency of high levels of automation without degrading human performance. One example of a new NPP concept that will utilize greater degrees of automation is the SMR concept from NuScale Power. The NuScale Power design requires 12 modular units to be operated in one single control room, which leads to a need for higher degrees of automation in the control room. Idaho National Laboratory (INL) researchers and NuScale Power human factors and operations staff are working on a collaborative project to address the human performance challenges of increased automation and to determine the principles that lead to optimal performance in highly automated systems. This paper will describe this concept in detail and will describe an experimental test of the concept. The benefits and challenges of the approach will be discussed.

Advanced sulfur control concepts for hot gas desulfurization technology

International Nuclear Information System (INIS)

1998-01-01

The objective of this project is to develop a hot-gas desulfurization process scheme for control of H 2 S in HTHP coal gas that can be more simply and economically integrated with known regenerable sorbents in DOE/METC-sponsored work than current leading hot-gas desulfurization technologies. In addition to being more economical, the process scheme to be developed must yield an elemental sulfur byproduct. The Direct Sulfur Recovery Process (DSRP), a leading process for producing an elemental sulfur byproduct in hot-gas desulfurization systems, incurs a coal gas use penalty, because coal gas is required to reduce the SO 2 in regeneration off-gas to elemental sulfur. Alternative regeneration schemes, which avoid coal gas use and produce elemental sulfur, will be evaluated. These include (i) regeneration of sulfided sorbent using SO 2 ; (ii) partial oxidation of sulfided sorbent in an O 2 starved environment; and (iii) regeneration of sulfided sorbent using steam to produce H 2 S followed by direct oxidation of H 2 S to elemental sulfur. Known regenerable sorbents will be modified to improve the feasibility of the above alternative regeneration approaches. Performance characteristics of the modified sorbents and processes will be obtained through lab- and bench-scale testing. Technical and economic evaluation of the most promising processes concept(s) will be carried out

New Approach to Concept Feasibility and Design Studies for Astrophysics Missions

Science.gov (United States)

Deutsch, M. J.; McLaughlin, W.; Nichols, J.

1998-01-01

JPL has assembled a team of multidisciplinary experts with corporate knowledge of space mission and instrument development. The advanced Concept Design Team, known as Team X, provides interactive design trades including cost as a design parameter, and advanced visualization for pre-Phase A Studies.

Advanced Placement Economics Improves Both Merit and Equity

Science.gov (United States)

Meek, Sally; Morton, John

2009-01-01

In 1989, microeconomics and macroeconomics examinations debuted on the Advanced Placement (AP) scene. At that time, many professors of economics were skeptical that college freshmen had the skills and maturity to understand the concepts in principles of economics courses. They thought teaching these concepts to high school students was even more…

An advanced concept that promises ecological and economic viability

Science.gov (United States)

Wright, B. R.; Sedgwick, T. A.; Urie, D. M.

1976-01-01

The actuality of supersonic commercial service being provided by Concorde is demonstrating to the world the advantages offered by supersonic travel for both business and recreation. Public acceptance will gradually and persistently stimulate interest to proceed with a second generation design that meets updated economic and ecological standards. It is estimated that this concept could operate profitably on world-wide routes with a revenue structure based upon economy fares. Airplanes will meet all present day ecological requirements regarding noise and emissions.

Developing the MAPLE materials test reactor concept

International Nuclear Information System (INIS)

Lee, A.G.; Lidstone, R.F.; Donnelly, J.V.

1992-05-01

MAPLE-MTR is a new multipurpose research facility being planned by AECL Research as a possible replacement for the 35-year-old NRU reactor. In developing the MAPLE-MTR concept, AECL is starting from the recent design and licensing experience with the MAPLE-X10 reactor. By starting from technology developed to support the MAPLE-X10 design and adapting it to produce a concept that satisfies the requirements of fuel channel materials testing and fuel irradiation programs, AECL expects to minimize the need for major advances in nuclear technology (e.g., fuel, heat transfer). Formulation of the MAPLE-MTR concept is at an early stage. This report describes the irradiation requirements of the research areas, how these needs are translated into design criteria for the project and elements of the preliminary design concept

The German joint research project "concepts for future gravity satellite missions"

Science.gov (United States)

Reubelt, Tilo; Sneeuw, Nico; Fichter, Walter; Müller, Jürgen

2010-05-01

Within the German joint research project "concepts for future gravity satellite missions", funded by the Geotechnologies programme of the German Federal Ministry of Education and Research, options and concepts for future satellite missions for precise (time-variable) gravity field recovery are investigated. The project team is composed of members from science and industry, bringing together experts in geodesy, satellite systems, metrology, sensor technology and control systems. The majority of team members already contributed to former gravity missions. The composition of the team guarantees that not only geodetic aspects and objectives are investigated, but also technological and financial constraints are considered. Conversely, satellite, sensor and system concepts are developed and improved in a direct exchange with geodetic and scientific claims. The project aims to develop concepts for both near and mid-term future satellite missions, taking into account e.g. advanced satellite formations and constellations, improved orbit design, innovative metrology and sensor systems and advances in satellite systems.

Proceedings of GLOBAL 2007 conference on advanced nuclear fuel cycles and systems

International Nuclear Information System (INIS)

2007-01-01

In keeping with the 12-year history of this conference, GLOBAL 2007 focuses on future nuclear energy systems and fuel cycles. With the increasing public acceptance and political endorsement of nuclear energy, it is a pivotal time for nuclear energy research. Significant advances have been made in development of advanced nuclear fuels and materials, reactor designs, partitioning, transmutation and reprocessing technologies, and waste management strategies. In concert with the technological advances, it is more important than ever to develop sensible nuclear proliferation policies, to promote sustainability, and to continue to increase international collaboration. To further these aims, GLOBAL 2007 highlights recent developments in the following areas: advanced integrated fuel cycle concepts, spent nuclear fuel reprocessing, advanced reprocessing technology, advanced fuels and materials, advanced waste management technology, novel concepts for waste disposal and repository development, advanced reactors, partitioning and transmutation, developments in nuclear non-proliferation technology, policy, and implementation, sustainability and expanded global utilization of nuclear energy, and international collaboration on nuclear energy

OPTIMIZATION OF ADVANCED FILTER SYSTEMS; TOPICAL

International Nuclear Information System (INIS)

R.A. Newby; G.J. Bruck; M.A. Alvin; T.E. Lippert

1998-01-01

Reliable, maintainable and cost effective hot gas particulate filter technology is critical to the successful commercialization of advanced, coal-fired power generation technologies, such as IGCC and PFBC. In pilot plant testing, the operating reliability of hot gas particulate filters have been periodically compromised by process issues, such as process upsets and difficult ash cake behavior (ash bridging and sintering), and by design issues, such as cantilevered filter elements damaged by ash bridging, or excessively close packing of filtering surfaces resulting in unacceptable pressure drop or filtering surface plugging. This test experience has focused the issues and has helped to define advanced hot gas filter design concepts that offer higher reliability. Westinghouse has identified two advanced ceramic barrier filter concepts that are configured to minimize the possibility of ash bridge formation and to be robust against ash bridges should they occur. The ''inverted candle filter system'' uses arrays of thin-walled, ceramic candle-type filter elements with inside-surface filtering, and contains the filter elements in metal enclosures for complete separation from ash bridges. The ''sheet filter system'' uses ceramic, flat plate filter elements supported from vertical pipe-header arrays that provide geometry that avoids the buildup of ash bridges and allows free fall of the back-pulse released filter cake. The Optimization of Advanced Filter Systems program is being conducted to evaluate these two advanced designs and to ultimately demonstrate one of the concepts in pilot scale. In the Base Contract program, the subject of this report, Westinghouse has developed conceptual designs of the two advanced ceramic barrier filter systems to assess their performance, availability and cost potential, and to identify technical issues that may hinder the commercialization of the technologies. A plan for the Option I, bench-scale test program has also been developed based

Manufacturing concepts and development trends in the industrial production of microelectromechanical systems

Science.gov (United States)

Schuenemann, Matthias; Grimme, Ralf; Kaufmann, Thomas; Schwaab, Gerhard; Baeder, Uwe; Schaefer, Wolfgang; Dorner, Johann

1998-01-01

During the past few years, remarkable affords have been made for the realization of microscale sensors, actuators and microelectromechanical system. Due to advances in solid state and micromachining technologies, significant advances in designing, fabricating and testing of microminiaturized devices have been achieved at laboratory level. However, the technical and economical realization of microelectromechanical systems is considerably impeded by the lack of satisfying device technology for their industrial production. A production concept for the industrial production of hybrid microelectromechanical systems was developed and investigated. The concept is based on the resources and requirements of medium-sized enterprises and is characterized by its flexibility. Microsystem fabrication is separated into microfabrication steps performed in-house and technological steps performed by external technology providers. The modularity of the concept allows for a gradual increase in the degree of automation and the in-house production depth, depending on market capacity and financial resources. To demonstrate the feasibility of this approach, the design and realization of a microfabrication process center, which includes tasks like transport and handling, processing, cleaning, testing and storing are discussed. Special attention is given to the supply and feeding of microparts, to the necessary magazines, trays and transport systems, to the implementation of homogeneous mechanical, environmental and information interfaces, to the employment of advanced control, scheduling, and lot tracking concepts, and to the application of highly modular and cost-efficient clean production concepts.

A novel superconducting toroidal field magnetic concept using advanced materials

International Nuclear Information System (INIS)

Schwartz, J.

1991-01-01

The plasma physics database indicates that two distinct approaches to tokamak design may lead to commercial fusion reactors: Low Aspect ratio, high plasma current, relatively low magnetic field devices, and high Aspect ratio, high field devices. The former requires significant enhancements in plasma performance, while the latter depends primarily upon technology development. The key technology for the commercialization of the high-field approach is large, high magnetic field superconducting magnets. In this paper, the physics motivation for the high field approach and key superconducting magnet (SCM) development issues are reviewed. Improved SCM performance may be obtained from improved materials and/or improved engineering. Superconducting materials ranging from NbTi to high-T c oxides are reviewed, demonstrating the broad range of potential superconducting materials. Structural material options are discussed, including cryogenic steel alloys and fiber-reinforced composite materials. The potential for improved magnet engineering is quantified in terms of the Virial Theorem Limit, and two examples of approaches to highly optimized magnet configurations are discussed. The force-reduced concept, which is a finite application of the force-free solutions to Ampere's Law, appear promising for large SCMs but may be limited by the electromagnetics of a fusion plasma. The Solid Superconducting Cylinder (SSC) concept is proposed. This concept combines the unique properties of high-T c superconductors within a low-T c SCM to obtain (1) significant reductions in the structural material volume, (2) a decoupling of the tri-axial (compressive and tensile) stress rate, and (3) a demountable TF magnet system. The advantages of this approach are quantified in terms of a 24 T commercial reactor TF magnet system. Significant reductions in the mechanical stress and the TF radial build are demonstrated. 54 refs., 14 figs., 5 tabs

Advanced Magnetic Nanostructures

CERN Document Server

Sellmyer, David

2006-01-01

Advanced Magnetic Nanostructures is devoted to the fabrication, characterization, experimental investigation, theoretical understanding, and utilization of advanced magnetic nanostructures. Focus is on various types of 'bottom-up' and 'top-down' artificial nanostructures, as contrasted to naturally occurring magnetic nanostructures, such as iron-oxide inclusions in magnetic rocks, and to structures such as perfect thin films. Chapter 1 is an introduction into some basic concepts, such as the definitions of basic magnetic quantities. Chapters 2-4 are devoted to the theory of magnetic nanostructures, Chapter 5 deals with the characterization of the structures, and Chapters 6-10 are devoted to specific systems. Applications of advanced magnetic nanostructures are discussed in Chapters11-15 and, finally, the appendix lists and briefly discusses magnetic properties of typical starting materials. Industrial and academic researchers in magnetism and related areas such as nanotechnology, materials science, and theore...

Report on the Lake Arrowhead workshop on advanced acceleration concepts

International Nuclear Information System (INIS)

Pellegrini, C.

1989-03-01

We review the present status of the field of New Acceleration Concepts, as presented at the Lake Arrowhead workshop, held at the beginning of 1989. Many new and promising results have been obtained recently, and the field is actively developing. We discuss briefly some of the main results presented at the workshop. 43 refs., 2 tabs

Advanced maintenance research programs

International Nuclear Information System (INIS)

Marston, T.U.; Gelhaus, F.; Burke, R.

1985-01-01

The purpose of this paper is to provide the reader with an idea of the advanced maintenance research program at the Electric Power Research Institute (EPRI). A brief description of the maintenance-related activities is provided as a foundation for the advanced maintenance research projects. The projects can be divided into maintenance planning, preventive maintenance program development and implementation, predictive (or conditional) maintenance, and innovative maintenance techniques. The projects include hardware and software development, human factors considerations, and technology promotion and implementation. The advanced concepts include: the incorporation of artificial intelligence into outage planning; turbine and pump maintenance; rotating equipment monitoring and diagnostics with the aid of expert systems; and the development of mobile robots for nuclear power plant maintenance

Evaluation of a Hydrogen Fuel Cell Powered Blended-Wing-Body Aircraft Concept for Reduced Noise and Emissions

Science.gov (United States)

Guynn, Mark D.; Freh, Joshua E.; Olson, Erik D.

2004-01-01

This report describes the analytical modeling and evaluation of an unconventional commercial transport aircraft concept designed to address aircraft noise and emission issues. A blended-wing-body configuration with advanced technology hydrogen fuel cell electric propulsion is considered. Predicted noise and emission characteristics are compared to a current technology conventional configuration designed for the same mission. The significant technology issues which have to be addressed to make this concept a viable alternative to current aircraft designs are discussed. This concept is one of the "Quiet Green Transport" aircraft concepts studied as part of NASA's Revolutionary Aerospace Systems Concepts (RASC) Program. The RASC Program was initiated to develop revolutionary concepts that address strategic objectives of the NASA Enterprises, such as reducing aircraft noise and emissions, and to identify advanced technology requirements for the concepts.

Advanced nickel/hydrogen dependent pressure vessel (DPV) cell and battery concepts

Energy Technology Data Exchange (ETDEWEB)

Caldwell, D.B. [Technologies Div., Eagle Picher Industries, Inc., Joplin, MO (United States); Fox, C.L. [Technologies Div., Eagle Picher Industries, Inc., Joplin, MO (United States); Miller, L.E. [Technologies Div., Eagle Picher Industries, Inc., Joplin, MO (United States)

1997-03-01

The dependent pressure vessel (DPV) nickel/hydrogen (NiH{sub 2}) design is being developed by Eagle-Picher industries, Inc. (EPI) as an advanced battery for military and commercial aerospace and terrestrial applications. The DPV cell design offers high specific energy and energy density as well as reduced cost, while retaining the established individual pressure vessel (IPV) technology, flight heritage and database. This advanced DPV design also offers a more efficient mechanical, electrical and thermal cell and battery configuration and a reduced parts count. The DPV battery design promotes compact, minimum volume packaging and weight efficiency, and delivers cost and weight savings with minimal design risks. (orig.)

Mined Geologic Disposal System Concept of Operations

International Nuclear Information System (INIS)

Heidt, R.M.

1995-01-01

A Concept of Operations has been developed for the disposal of high-level radioactive waste in the potential geologic repository at Yucca Mountain. The Concept of Operations has been developed to document a cormion understanding of how the repository is to be operated. It is based on the repository architecture identified in the Initial Summary Report for Repository/Waste Package Advanced Conceptual Design and describes the operation of the repository from the initial receipt of waste through repository closure. Also described are operations for waste retrieval

Integrating collaborative concept mapping in case based learning

Directory of Open Access Journals (Sweden)

Alfredo Tifi

2013-03-01

Full Text Available Different significance of collaborative concept mapping and collaborative argumentation in Case Based Learning are discussed and compared in the different perspectives of answering focus questions, of fostering reflective thinking skills and in managing uncertainty in problem solving in a scaffolded environment. Marked differences are pointed out between the way concepts are used in constructing concept maps and the way meanings are adopted in case based learning through guided argumentation activities. Shared concept maps should be given different scopes, as for example a as an advance organizer in preparing a background system of concepts that will undergo transformation while accompanying the inquiry activities on case studies or problems; b together with narratives, to enhance awareness of the situated epistemologies that are being entailed in choosing certain concepts during more complex case studies, and c after-learning construction of a holistic vision of the whole domain by means of the most inclusive concepts, while scaffoldedcollaborative writing of narratives and arguments in describing-treating cases could better serve as a source of situated-inspired tools to create-refine meanings for particular concepts.

Status Report on Structural Materials for Advanced Nuclear Systems

International Nuclear Information System (INIS)

Allen, T.R.; Balbaud-Celerier, F.; Asayama, T.; Pouchon, M.; Busby, J.T.; Maloy, S.; Park, J.Y.; Fazio, C.; Dai, Y.; Agostini, P.; Chevalier, J.P.; Marrow, J.

2013-01-01

Materials performance is critical to the safe and economic operation of any nuclear system. As the international community pursues the development of Generation IV reactor concepts and accelerator-driven transmutation systems, it will be increasingly necessary to develop advanced materials capable of tolerating the more challenging environments of these new systems. The international community supports numerous materials research programmes, with each country determining its individual focus on a case-by-case basis. In many instances, similar alloys of materials systems are being studied in several countries, providing the opportunity for collaborative and cross-cutting research that benefits different systems. This report is a snapshot of the current materials programmes supporting the development of advanced concepts. The descriptions of the research are grouped by concept, and national programmes are described within each concept. The report provides an overall sense of the importance of materials research worldwide and the opportunities for synergy among the countries represented in this overview. (authors)

Physics of plutonium and americium recycling in PWR using advanced fuel concepts

International Nuclear Information System (INIS)

Hourcade, E.

2004-01-01

PWR waste inventory management is considered in many countries including Frances as one of the main current issues. Pu and Am are the 2 main contents both in term of volume and long term radio-toxicity. Waiting for the Generation IV systems implementation (2035-2050), one of the mid-term solutions for their transmutation involves the use of advanced fuels in Pressurized Water Reactors (PWR). These have to require as little modification as possible of the core internals, the cooling system and fuel cycle facilities (fabrication and reprocessing). The first part of this paper deals with some neutronic characteristics of Pu and/or Am recycling. In a second part, 2 technical solutions MOX-HMR and APA-DUPLEX-84 are presented and the third part is devoted to the study of a few global strategies. The main neutronic parameters to be considered for Pu and Am recycling in PWR are void coefficient, Doppler coefficient, fraction of delayed neutrons and power distribution (especially for heterogeneous configurations). The modification of the moderation ratio, the opportunity to use inert matrices (targets), the optimisation of Uranium, Plutonium and Americium contents are the key parameters to play with. One of the solutions (APA-DUPLEX-84) presented here is a heterogeneous assembly with regular moderation ratio composed with both target fuel rods (Pu and Am embedded in an inert matrix) and standard UO 2 fuel rods. An EPR (European Pressurised Reactor) type reactor, loaded only with assemblies containing 84 peripheral targets, can reach an Americium consumption rate of (4.4; 23 kg/TWh) depending on the assembly concept. For Pu and Am inventories stabilisation, the theoretical fraction of reactors loaded with Pu + Am or Pu assemblies is about 60%. For Americium inventory stabilisation, the fraction decreases down to 16%, but Pu is produced at a rate of 18.5 Kg/TWh (-25% compared to one through UOX cycle)

Technology for advanced focal plane arrays of HgCdTe and AIGaN

CERN Document Server

He, Li; Ni, Guoqiang

2016-01-01

This book introduces the basic framework of advanced focal plane technology based on the third-generation infrared focal plane concept. The essential concept, research advances, and future trends in advanced sensor arrays are comprehensively reviewed. Moreover, the book summarizes recent research advances in HgCdTe/AlGaN detectors for the infrared/ultraviolet waveband, with a particular focus on the numerical method of detector design, material epitaxial growth and processing, as well as Complementary Metal-Oxide-Semiconductor Transistor readout circuits. The book offers a unique resource for all graduate students and researchers interested in the technologies of focal plane arrays or electro-optical imaging sensors.

Development of inherent core technologies for advanced reactor

International Nuclear Information System (INIS)

Kim, Keung Koo; Noh, J.M.; Hwang, D.H.

1999-03-01

Recently, the developed countries made their effort on developing the advanced reactor which will result in significantly enhanced safety and economy. However, they will protect the advanced reactor and its design technology with patent and proprietary right. Therefore, it is very important to develop our own key core concepts and inherent core design technologies which can form a foundation of indigenous technologies for development of the domestic advanced reactor in order to keep the superiority in the nuclear plant building market among the developing countries. In order to provide the basic technology for the core design of advanced reactor, this project is for developing the inherent core design concepts with enhanced safety and economy, and associated methodologies and technologies for core analyses. The feasibility study of constructing domestic critical facilities are performed by surveying the status and utilization of foreign facilities and by investigating the demand for domestic facilities. The research results developed in this project, such as core analysis methodologies for hexagonal core, conceptual core design based on hexagonal fuel assemblies and soluble boron core design and control strategies, will provide a technical foundation in developing core design of domestic advanced reactor. Furthermore, they will strengthen the competitiveness of Korean nuclear technology. We also expect that some of the design concepts developed in this project to improve the reactor safety and economy can be applicable to the design of advanced reactor. This will significantly reduce the public anxiety on the nuclear power plant, and will contribute to the economy of construction and operation for the future domestic reactors. Even though the critical facility will not be constructed right now, the investigation of the status and utilization of foreign critical facility will contribute to the future critical facility construction. (author). 150 refs., 34 tabs., 103

Development of inherent core technologies for advanced reactor

Energy Technology Data Exchange (ETDEWEB)

Kim, Keung Koo; Noh, J.M.; Hwang, D.H. [and others

1999-03-01

Recently, the developed countries made their effort on developing the advanced reactor which will result in significantly enhanced safety and economy. However, they will protect the advanced reactor and its design technology with patent and proprietary right. Therefore, it is very important to develop our own key core concepts and inherent core design technologies which can form a foundation of indigenous technologies for development of the domestic advanced reactor in order to keep the superiority in the nuclear plant building market among the developing countries. In order to provide the basic technology for the core design of advanced reactor, this project is for developing the inherent core design concepts with enhanced safety and economy, and associated methodologies and technologies for core analyses. The feasibility study of constructing domestic critical facilities are performed by surveying the status and utilization of foreign facilities and by investigating the demand for domestic facilities. The research results developed in this project, such as core analysis methodologies for hexagonal core, conceptual core design based on hexagonal fuel assemblies and soluble boron core design and control strategies, will provide a technical foundation in developing core design of domestic advanced reactor. Furthermore, they will strengthen the competitiveness of Korean nuclear technology. We also expect that some of the design concepts developed in this project to improve the reactor safety and economy can be applicable to the design of advanced reactor. This will significantly reduce the public anxiety on the nuclear power plant, and will contribute to the economy of construction and operation for the future domestic reactors. Even though the critical facility will not be constructed right now, the investigation of the status and utilization of foreign critical facility will contribute to the future critical facility construction. (author). 150 refs., 34 tabs., 103

Advanced Control Test Operation (ACTO) facility

International Nuclear Information System (INIS)

Ball, S.J.

1987-01-01

The Advanced Control Test Operation (ACTO) project, sponsored by the US Department of Energy (DOE), is being developed to enable the latest modern technology, automation, and advanced control methods to be incorporated into nuclear power plants. The facility is proposed as a national multi-user center for advanced control development and testing to be completed in 1991. The facility will support a wide variety of reactor concepts, and will be used by researchers from Oak Ridge National Laboratory (ORNL), plus scientists and engineers from industry, other national laboratories, universities, and utilities. ACTO will also include telecommunication facilities for remote users

A new advanced safe nuclear reactor concept

International Nuclear Information System (INIS)

Sefidvash, Farhang

1999-01-01

The reactor design is based on fluidized bed concept and utilizes pressurized water reactor technology. The fuel is automatically removed from the reactor by gravity under any accident condition. The reactor demonstrates the characteristics of inherent safety and passive cooling. Here two options for modification to the original design are proposed in order to increase the stability and thermal efficiency of the reactor. A modified version of the reactor involves the choice of supercritical steam as the coolant to produce a plant thermal efficiency of about 40%. Another is to modify the shape of the reactor core to produce a non-fluctuating bed and consequently guarantee the dynamic stability of the reactor. The mixing of Tantalum in the fuel is also proposed as an additional inhibition to power excursion. The spent fuel pellets may not be considered nuclear waste since they are in the shape and size that can easily be used as a a radioactive source for food irradiation and industrial applications. The reactor can easily operate with any desired spectrum by varying the porosity in order to be a plutonium burner or utilize a thorium fuel cycle. (author)

Advanced Interface for Tactical Security (AITS) Problem Analysis and Concept Definition

National Research Council Canada - National Science Library

Murray, S

1999-01-01

The Advanced Interface for Tactical Security (AITS) project was initiated to improve the task performance of security forces through technology and design improvements to information display systems...

Development of MMIS design concepts for the KNGR

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Kyun; Ku, In Su; Heo, Seop; Jeong, Chel Hwan; Lee, Hyun Chol; Park, Hui Yun; Lee, Chol Gwon; So, Yong Suk; Kim, Dong Hun; Jang, Gwi Sook; Lee, Ki Yonug; Lee, Jun; Kim, Young In [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

1995-12-01

The design goals of MMIS for the next generation nuclear power plant are to improve plant safety and the cost effectiveness of nuclear power plants, and to meet with regulatory requirements. For the optimized design of MMIS, conceptual design bases are required for the optimization of MMIS design to establish the design concepts for NGR MMIS. The conceptual design bases are also required for performing the basic design, and verifying the design. The objectives of this study are establishment of MMIS design bases and the development of next generation MMIS configuration concepts. The MMIS design bases for by adopting MMIS requirements developed in the previous study on next generation reactor evaluation techniques and advanced MMIS technologies. The next generation MMIS design requirements are to be developed based on the device obsolescence problems by applying modern digital technology. This report describes the design concepts for the next generation MMIS. In order to develop the design concepts, new technologies were analyzed, and the characteristics of new advanced MMIS designs were reviewed. In addition, reviewing the advanced design features (ADF) resulted from the 3 rd stage of standardization project, the strategy for the application of the results from these activities are prepared. This report includes the comparison results of the design characteristics of next generation MMIS with those of existing plants, YGN 3 and 4, UCN 3 and 4, and NUPLEX 80+. This report also describes the conceptual MMIS configuration of next generation control room, based on the results from the comparison. The results of this study will be an input for the detailed design guidelines and a regulatory requirements review report for the next generation MMIS design, and provide basis for the basis and detailed design of MMI and I and C for main control room. 1 fig., 1 tab., 46 refs. (Author) .new.

Development of MMIS design concepts for the KNGR

International Nuclear Information System (INIS)

Park, Jong Kyun; Ku, In Su; Heo, Seop; Jeong, Chel Hwan; Lee, Hyun Chol; Park, Hui Yun; Lee, Chol Gwon; So, Yong Suk; Kim, Dong Hun; Jang, Gwi Sook; Lee, Ki Yonug; Lee, Jun; Kim, Young In

1995-12-01

The design goals of MMIS for the next generation nuclear power plant are to improve plant safety and the cost effectiveness of nuclear power plants, and to meet with regulatory requirements. For the optimized design of MMIS, conceptual design bases are required for the optimization of MMIS design to establish the design concepts for NGR MMIS. The conceptual design bases are also required for performing the basic design, and verifying the design. The objectives of this study are establishment of MMIS design bases and the development of next generation MMIS configuration concepts. The MMIS design bases for by adopting MMIS requirements developed in the previous study on next generation reactor evaluation techniques and advanced MMIS technologies. The next generation MMIS design requirements are to be developed based on the device obsolescence problems by applying modern digital technology. This report describes the design concepts for the next generation MMIS. In order to develop the design concepts, new technologies were analyzed, and the characteristics of new advanced MMIS designs were reviewed. In addition, reviewing the advanced design features (ADF) resulted from the 3 rd stage of standardization project, the strategy for the application of the results from these activities are prepared. This report includes the comparison results of the design characteristics of next generation MMIS with those of existing plants, YGN 3 and 4, UCN 3 and 4, and NUPLEX 80+. This report also describes the conceptual MMIS configuration of next generation control room, based on the results from the comparison. The results of this study will be an input for the detailed design guidelines and a regulatory requirements review report for the next generation MMIS design, and provide basis for the basis and detailed design of MMI and I and C for main control room. 1 fig., 1 tab., 46 refs. (Author) .new

The second advanced lead lithium blanket concept using ODS steel as structural material and SiCf/SiC flow channel inserts as electrical and thermal insulators (Task PPA 2.5). Final report

International Nuclear Information System (INIS)

Norajitra, P.; Buehler, L.; Fischer, U.

1999-12-01

Preparatory work on the advanced dual coolant (A-DCL) blanket concept using SiC f /SiC flow channel inserts as electrical and thermal insulators has been carried out at the Forschungszentrum Karlsruhe in co-operation with CEA as a conceptual design proposal to the EU fusion power plant study planned to be launched in 2000 within the framework of the EU fusion programme with the main objective of specifying the characteristics of an attractive and viable commercial D-T fusion power plant. The basic principles and design characteristics of this A-DCL blanket concept are presented and its potential with regard to performance (neutron wall load, lifetime, availability) is discussed in this report. The results of this study show that the A-DCL blanket concept has a high potential for further development due to its high thermal efficiency and its simple concept solution. (orig.) [de

PENERAPAN MODEL PEMBELAJARAN ADVANCE ORGANIZER BERVISI SETS TERHADAP PENINGKATAN PENGUASAAN KONSEP KIMIA

Directory of Open Access Journals (Sweden)

Ilam Pratitis

2015-11-01

Full Text Available This study aims to determine the effect of the application of learning model with advance organizer envisions SETS to increase mastery of chemistry concepts in the high school in Semarang on buffer solution material. The design used in this research is the design of the control group non equivalent. Sampling was conducted with a purposive sampling technique, and obtained a XI 6 science grade as experimental class and class XI 5 science grade as control class. Data collection method used is the method of documentation, testing, observation, and questionnaires. The results showed that the average cognitive achievement of experimental class was 84, while the control class was 82. The result of data analysis showed that the effect of the application of learning model with advance organizer envisions SETS was able to increase the mastery of chemical concepts of 4%, with a correlation rate of 0.2. Based on the results, it can be concluded that the learning model with advance organizer envisions SETS had positive effect of increasing mastery of the concept of chemistry on buffer solution material. The advice given is learning model with organizer envisions SETS should also be applied to other chemistry materials. This is of course accompanied by a change in order to suit the needs of its effect on learning outcomes in the form of concept mastery of chemistry to be more increased.Keywords: Advance Organizer, Buffer Solution, Concept Mastery, SETS

Review of key concepts in magnetic resonance physics

Energy Technology Data Exchange (ETDEWEB)

Moore, Michael M. [Penn State Hershey Children' s Hospital, Department of Radiology, The Pennsylvania State College of Medicine, Hershey, PA (United States); Chung, Taylor [UCSF Benioff Children' s Hospital Oakland, Department of Diagnostic Imaging, Oakland, CA (United States)

2017-05-15

MR physics can be a challenging subject for practicing pediatric radiologists. Although many excellent texts provide very comprehensive reviews of the field of MR physics at various levels of understanding, the authors of this paper explain several key concepts in MR physics that are germane to clinical practice in a non-rigorous but practical fashion. With the basic understanding of these key concepts, practicing pediatric radiologists can build on their knowledge of current clinical MR techniques and future advances in MR applications. Given the challenges of both the increased need for rapid imaging in non-sedated children and the rapid physiological cardiovascular and respiratory motion in pediatric patients, many advances in complex MR techniques are being applied to imaging these children. The key concepts are as follows: (1) structure of a pulse sequence, (2) k-space, (3) ''trade-off triangle'' and (4) fat suppression. This review is the first of five manuscripts in a minisymposium on pediatric MR. The authors' goal for this review is to aid in understanding the MR techniques described in the subsequent manuscripts on brain imaging and body imaging in this minisymposium. (orig.)

Review of key concepts in magnetic resonance physics.

Science.gov (United States)

Moore, Michael M; Chung, Taylor

2017-05-01

MR physics can be a challenging subject for practicing pediatric radiologists. Although many excellent texts provide very comprehensive reviews of the field of MR physics at various levels of understanding, the authors of this paper explain several key concepts in MR physics that are germane to clinical practice in a non-rigorous but practical fashion. With the basic understanding of these key concepts, practicing pediatric radiologists can build on their knowledge of current clinical MR techniques and future advances in MR applications. Given the challenges of both the increased need for rapid imaging in non-sedated children and the rapid physiological cardiovascular and respiratory motion in pediatric patients, many advances in complex MR techniques are being applied to imaging these children. The key concepts are as follows: (1) structure of a pulse sequence, (2) k-space, (3) "trade-off triangle" and (4) fat suppression. This review is the first of five manuscripts in a minisymposium on pediatric MR. The authors' goal for this review is to aid in understanding the MR techniques described in the subsequent manuscripts on brain imaging and body imaging in this minisymposium.

Cancer survivorship: Advancing the concept in the context of colorectal cancer.

Science.gov (United States)

Drury, Amanda; Payne, Sheila; Brady, Anne-Marie

2017-08-01

Previous conceptualizations of cancer survivorship have focused on heterogeneous cancer survivors, with little consideration of the validity of conclusions for homogeneous tumour groups. This paper aims to examine the concept of cancer survivorship in the context of colorectal cancer (CRC). Rodgers' (1989) Evolutionary Method of Concept Analysis guided this study. A systematic search of PUBMED, CINAHL, PsycINFO and The Cochrane Library was conducted in November 2016 to identify studies of CRC survivorship. The Braun and Clarke (2006) framework guided the analysis and interpretation of data extracted from eighty-five publications. Similar to general populations of cancer survivors, CRC survivors experience survivorship as an individual, life-changing process, punctuated by uncertainty and a duality of positive and negative outcomes affecting quality of life. However, CRC survivors experience specific concerns arising from the management of their disease. The concept of cancer survivorship has evolved over the past decade as the importance of navigating the healthcare system and its resources, and the constellation of met and unmet needs of cancer survivors are realised. The results highlight core similarities between survivorship in the context of CRC and other tumour groups, but underlines issues specific to CRC survivorship. Communication and support are key issues in survivorship care which may detrimentally affect CRC survivors' well-being if they are inadequately addressed. Healthcare professionals (HCP's) therefore have a duty to ensure cancer survivors' health, information and supportive care needs are met in the aftermath of treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

Advanced Neutron Source (ANS) Project progress report

International Nuclear Information System (INIS)

McBee, M.R.; Chance, C.M.

1990-04-01

This report discusses the following topics on the advanced neutron source: quality assurance (QA) program; reactor core development; fuel element specification; corrosion loop tests and analyses; thermal-hydraulic loop tests; reactor control concepts; critical and subcritical experiments; material data, structural tests, and analysis; cold source development; beam tube, guide, and instrument development; hot source development; neutron transport and shielding; I ampersand C research and development; facility concepts; design; and safety

Advanced calculus a transition to analysis

CERN Document Server

Dence, Thomas P

2010-01-01

Designed for a one-semester advanced calculus course, Advanced Calculus explores the theory of calculus and highlights the connections between calculus and real analysis -- providing a mathematically sophisticated introduction to functional analytical concepts. The text is interesting to read and includes many illustrative worked-out examples and instructive exercises, and precise historical notes to aid in further exploration of calculus. Ancillary list: * Companion website, Ebook- http://www.elsevierdirect.com/product.jsp?isbn=9780123749550 * Student Solutions Manual- To come * Instructor

Advanced supersonic propulsion study, phases 3 and 4. [variable cycle engines

Science.gov (United States)

Allan, R. D.; Joy, W.

1977-01-01

An evaluation of various advanced propulsion concepts for supersonic cruise aircraft resulted in the identification of the double-bypass variable cycle engine as the most promising concept. This engine design utilizes special variable geometry components and an annular exhaust nozzle to provide high take-off thrust and low jet noise. The engine also provides good performance at both supersonic cruise and subsonic cruise. Emission characteristics are excellent. The advanced technology double-bypass variable cycle engine offers an improvement in aircraft range performance relative to earlier supersonic jet engine designs and yet at a lower level of engine noise. Research and technology programs required in certain design areas for this engine concept to realize its potential benefits include refined parametric analysis of selected variable cycle engines, screening of additional unconventional concepts, and engine preliminary design studies. Required critical technology programs are summarized.

The Framatome RCVS concept and physics

International Nuclear Information System (INIS)

Vallee, A.; Millot, J.P.; Bruna, G.

1986-06-01

We have tried through this presentation to emphasize on what FRAMATOME thinks to be the most specific problems of the advanced RCVS (Reactor core with spectral shift) core concept (Spectral shift, voidage, reactivity control). Besides, FRAMATOME is analysing the most important safety related topics typically LOCA and DNBR, and has launched developments on them, in connection with CEA. The core behaviour during a loss of Coolant Accident is quite similar to PWR's, the pitch between rods being sufficiently large for clad ballooning not to cause any damage. To conclude, the core improvements developed by FRAMATOME on the RCVS concept economize the use of fissile materials

Recent advances in alcohol withdrawal states.

Science.gov (United States)

Fialkov, M J

1977-11-26

Recent advances in alcohol withdrawal states are described. New concepts of classification, the development of the syndrome and its management are outlined. In the light of recent research, more optimistic results for this much maligned but common condition may be achieved.

Application of Design of Experiments and Surrogate Modeling within the NASA Advanced Concepts Office, Earth-to-Orbit Design Process

Science.gov (United States)

Zwack, Mathew R.; Dees, Patrick D.; Holt, James B.

2016-01-01

Decisions made during early conceptual design have a large impact upon the expected life-cycle cost (LCC) of a new program. It is widely accepted that up to 80% of such cost is committed during these early design phases. Therefore, to help minimize LCC, decisions made during conceptual design must be based upon as much information as possible. To aid in the decision making for new launch vehicle programs, the Advanced Concepts Office (ACO) at NASA Marshall Space Flight Center (MSFC) provides rapid turnaround pre-phase A and phase A concept definition studies. The ACO team utilizes a proven set of tools to provide customers with a full vehicle mass breakdown to tertiary subsystems, preliminary structural sizing based upon worst-case flight loads, and trajectory optimization to quantify integrated vehicle performance for a given mission. Although the team provides rapid turnaround for single vehicle concepts, the scope of the trade space can be limited due to analyst availability and the manpower requirements for manual execution of the analysis tools. In order to enable exploration of a broader design space, the ACO team has implemented an advanced design methods (ADM) based approach. This approach applies the concepts of design of experiments (DOE) and surrogate modeling to more exhaustively explore the trade space and provide the customer with additional design information to inform decision making. This paper will first discuss the automation of the ACO tool set, which represents a majority of the development effort. In order to fit a surrogate model within tolerable error bounds a number of DOE cases are needed. This number will scale with the number of variable parameters desired and the complexity of the system's response to those variables. For all but the smallest design spaces, the number of cases required cannot be produced within an acceptable timeframe using a manual process. Therefore, automation of the tools was a key enabler for the successful

The Digital Outcasts - Advanced Margins in Digital Societies

DEFF Research Database (Denmark)

Hjelholt, Morten

2015-01-01

This work-in-progress paper reports on preliminary findings from 15 interviews with so called “non-digital” Danish citizens to address and problematize this classification as a social category. In linking classification theory (the categories used in the digital post system) to a notion of advanced...... further work will use the concept of advanced digital marginalization, to elaborate on these findings....

Considering Intermittent Dormancy in an Advanced Life Support Systems Architecture

Science.gov (United States)

Sargusingh, Miriam J.; Perry, Jay L.

2017-01-01

Many advanced human space exploration missions being considered by the National Aeronautics and Space Administration (NASA) include concepts in which in-space systems cycle between inhabited and uninhabited states. Managing the life support system (LSS) may be particularly challenged during these periods of intermittent dormancy. A study to identify LSS management challenges and considerations relating to dormancy is described. The study seeks to define concepts suitable for addressing intermittent dormancy states and to evaluate whether the reference LSS architectures being considered by the Advanced Exploration Systems (AES) Life Support Systems Project (LSSP) are sufficient to support this operational state. The primary focus of the study is the mission concept considered to be the most challenging-a crewed Mars mission with an extensive surface stay. Results from this study are presented and discussed.

A biased competition theory of cytotoxic T lymphocyte interaction with tumor nodules.

Directory of Open Access Journals (Sweden)

Claire Christophe

Full Text Available The dynamics of the interaction between Cytotoxic T Lymphocytes (CTL and tumor cells has been addressed in depth, in particular using numerical simulations. However, stochastic mathematical models that take into account the competitive interaction between CTL and tumors undergoing immunoediting, a process of tumor cell escape from immunesurveillance, are presently missing. Here, we introduce a stochastic dynamical particle interaction model based on experimentally measured parameters that allows to describe CTL function during immunoediting. The model describes the competitive interaction between CTL and melanoma cell nodules and allows temporal and two-dimensional spatial progression. The model is designed to provide probabilistic estimates of tumor eradication through numerical simulations in which tunable parameters influencing CTL efficacy against a tumor nodule undergoing immunoediting are tested. Our model shows that the rate of CTL/tumor nodule productive collisions during the initial time of interaction determines the success of CTL in tumor eradication. It allows efficient cytotoxic function before the tumor cells acquire a substantial resistance to CTL attack, due to mutations stochastically occurring during cell division. Interestingly, a bias in CTL motility inducing a progressive attraction towards a few scout CTL, which have detected the nodule enhances early productive collisions and tumor eradication. Taken together, our results are compatible with a biased competition theory of CTL function in which CTL efficacy against a tumor nodule undergoing immunoediting is strongly dependent on guidance of CTL trajectories by scout siblings. They highlight unprecedented aspects of immune cell behavior that might inspire new CTL-based therapeutic strategies against tumors.

Moving event and moving participant in aspectual conceptions

Directory of Open Access Journals (Sweden)

Izutsu Katsunobu

2016-06-01

Full Text Available This study advances an analysis of the event conception of aspectual forms in four East Asian languages: Ainu, Japanese, Korean, and Ryukyuan. As earlier studies point out, event conceptions can be divided into two major types: the moving-event type and the moving-participant type, respectively. All aspectual forms in Ainu and Korean, and most forms in Japanese and Ryukyuan are based on that type of event conception. Moving-participant oriented Ainu and movingevent oriented Japanese occupy two extremes, between which Korean and Ryukyuan stand. Notwithstanding the geographical relationships among the four languages, Ryukyuan is closer to Ainu than to Korean, whereas Korean is closer to Ainu than to Japanese.

Creativity: a refinement of the concept for nursing practice.

Science.gov (United States)

Fasnacht, Patsy H

2003-01-01

This paper seeks to remove some of the ambiguity surrounding the conceptual meaning of creativity using techniques of concept refinement to advance the concept. Creativity is an essential component of nursing practice that occurs daily in nurse's interactions with clients, families and other nurses. Failure to acknowledge and encourage creativity in beginning nurses may hinder future development and innovations in nursing practice and in nursing science. In order to promote the development of creativity it is first necessary to clarify and refine the concept as it applies to nursing. A comprehensive review of a variety of computer and online databases resulted in thousands of articles on creativity between the years 1966 and 1999. The final sample (n = 48) was obtained using both stratified random and purposive sampling techniques. A content analysis of the literature was conducted using methods identified by Morse and illustrated in the work of Hupcey et al. Having determined the concept to be partially mature, the concept was advanced using techniques of concept refinement. Content analysis of the literature yielded three differing definitions for creativity: revelation, birth and reincarnation. Creativity occurs in the presence of intrinsic motivation and a nurturing environment. While value is often used to identify whether a product is creative, the value of the product cannot determine whether the process has occurred. The product produced determines evidence of the process of creativity. Limitations of this investigation are the use of secondary sources and the relatively small sample size (n = 48). Refinement of the concept of creativity indicates that it is a process that may be developed and influenced by the environment and is recognized by the product produced. Further investigation is needed to explore methods and techniques for developing creativity in nursing.

Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.

Directory of Open Access Journals (Sweden)

Jessica L Prince

Full Text Available Initial studies of 88 transmission pairs in the Zambia Emory HIV Research Project cohort demonstrated that the number of transmitted HLA-B associated polymorphisms in Gag, but not Nef, was negatively correlated to set point viral load (VL in the newly infected partners. These results suggested that accumulation of CTL escape mutations in Gag might attenuate viral replication and provide a clinical benefit during early stages of infection. Using a novel approach, we have cloned gag sequences isolated from the earliest seroconversion plasma sample from the acutely infected recipient of 149 epidemiologically linked Zambian transmission pairs into a primary isolate, subtype C proviral vector, MJ4. We determined the replicative capacity (RC of these Gag-MJ4 chimeras by infecting the GXR25 cell line and quantifying virion production in supernatants via a radiolabeled reverse transcriptase assay. We observed a statistically significant positive correlation between RC conferred by the transmitted Gag sequence and set point VL in newly infected individuals (p = 0.02. Furthermore, the RC of Gag-MJ4 chimeras also correlated with the VL of chronically infected donors near the estimated date of infection (p = 0.01, demonstrating that virus replication contributes to VL in both acute and chronic infection. These studies also allowed for the elucidation of novel sites in Gag associated with changes in RC, where rare mutations had the greatest effect on fitness. Although we observed both advantageous and deleterious rare mutations, the latter could point to vulnerable targets in the HIV-1 genome. Importantly, RC correlated significantly (p = 0.029 with the rate of CD4+ T cell decline over the first 3 years of infection in a manner that is partially independent of VL, suggesting that the replication capacity of HIV-1 during the earliest stages of infection is a determinant of pathogenesis beyond what might be expected based on set point VL alone.

Differently Structured Advance Organizers Lead to Different Initial Schemata and Learning Outcomes

Science.gov (United States)

Gurlitt, Johannes; Dummel, Sebastian; Schuster, Silvia; Nuckles, Matthias

2012-01-01

Does the specific structure of advance organizers influence learning outcomes? In the first experiment, 48 psychology students were randomly assigned to three differently structured advance organizers: a well-structured, a well-structured and key-concept emphasizing, and a less structured advance organizer. These were followed by a sorting task, a…

Physics and safety of advanced research reactors

International Nuclear Information System (INIS)

Boening, K.; Hardt, P. von der

1987-01-01

Advanced research reactor concepts are presently being developed in order to meet the neutron-based research needs of the nineties. Among these research reactors, which are characterized by an average power density of 1-10 MW per liter, highest priority is now generally given to the 'beam tube reactors'. These provide very high values of the thermal neutron flux (10 14 -10 16 cm -2 s -1 ) in a large volume outside of the reactor core, which can be used for sample irradiations and, in particular, for neutron scattering experiments. The paper first discusses the 'inverse flux trap concept' and the main physical aspects of the design and optimization of beam tube reactors. After that two examples of advanced research reactor projects are described which may be considered as two opposite extremes with respect to the physical optimization principle just mentioned. The present situation concerning cross section libraries and neutronic computer codes is more or less satisfactory. The safety analyses of advanced research reactors can largely be updated from those of current new designs, partially taking advantage of the immense volume of work done for power reactors. The paper indicates a few areas where generic problems for advanced research reactor safety are to be solved. (orig.)

Advances in endoscopic retrograde cholangiopancreatography

Directory of Open Access Journals (Sweden)

WANG Xiangping

2018-03-01

Full Text Available Endoscopic retrograde cholangiopancreatography (ERCP is a well-established advanced endoscopic technique for the diagnosis and treatment of pancreatobiliary diseases. New advances have been made in the treatment concept and techniques of ERCP in recent years. This article elaborates on the recent advances in ERCP, including the application of pancreatic duct stent, non-steroidal anti-inflammatory drugs, and aggressive hydration to prevent postoperative pancreatitis, covered metal stent for the treatment of benign bile duct stenosis, intraluminal radiofrequency ablation for malignant bile duct stenosis, extracorporeal shockwave lithotripsy and covered metal stent for the treatment of chronic pancreatitis, peroral choledochoscopy for qualitative diagnosis of bile duct stenosis and huge refractory stones, definition of difficult intubation, timing of pre-cut technique, and ERCP after gastrointestinal reconstruction.

What characterises a useful concept of causation in epidemiology?

DEFF Research Database (Denmark)

Olsen, Jørn

2003-01-01

, interpret and communicate our results. The component-cause model has considerably more to offer than a simple probabilistic concept. What a causal model has to offer to the advancement of the discipline is equally important as the concept itself. It has been said that we should not hunt “the Holy Grail......” (that is, determinism), if it does not exist. This line of reasoning neglects the fact that the “hunting” is more important than the “finding”....

Family-centred care of children in hospital - a concept analysis

DEFF Research Database (Denmark)

Mikkelsen, Gitte; Frederiksen, Kirsten

2011-01-01

from 1951 to 2009 resulted in a sample of 25 research articles. Review methods.  A theoretical concept analysis influenced by Risjord's distinction between theoretical and colloquial analyses and based on the principles developed by Morse, Hupcey and Penrod was used to examine the structure...... of professionals and families, mostly represented by mothers. Few attempts have been made to operationalize the concept. Conclusion.  Family-centred care is a partially mature and highly abstract concept. Developing a theory of family-centred care could position the concept in a theoretical context and should also......mikkelsen g. & frederiksen k. (2011) Family-centred care of children in hospital - a concept analysis. Journal of Advanced Nursing67(5), 1152-1162. ABSTRACT: Aim.  This paper reports a concept analysis of family-centred nursing care of hospitalized children. Background.  Family-centred care...

Guidance concepts for time-based flight operations

Science.gov (United States)

Vicroy, Dan D.

1990-01-01

Airport congestion and the associated delays are severe in today's airspace system and are expected to increase. NASA and the FAA is investigating various methods of alleviating this problem through new technology and operational procedures. One concept for improving airspace productivity is time-based control of aircraft. Research to date has focused primarily on the development of time-based flight management systems and Air Traffic Control operational procedures. Flight operations may, however, require special onboard guidance in order to satisfy the Air Traffic Control imposed time constraints. The results are presented of a simulation study aimed at evaluating several time-based guidance concepts in terms of tracking performance, pilot workload, and subjective preference. The guidance concepts tested varied in complexity from simple digital time-error feedback to an advanced time-referenced-energy guidance scheme.

Effects of developmental bisphenol A exposure on reproductive-related behaviors in California mice (Peromyscus californicus: a monogamous animal model.

Directory of Open Access Journals (Sweden)

Scott A Williams

Full Text Available Bisphenol A (BPA, a pervasive, endocrine disrupting compound (EDC, acts as a mixed agonist-antagonist with respect to estrogens and other steroid hormones. We hypothesized that sexually selected traits would be particularly sensitive to EDC. Consistent with this concept, developmental exposure of males from the polygynous deer mouse, Peromyscus maniculatus, to BPA resulted in compromised spatial navigational ability and exploratory behaviors, while there was little effect on females. Here, we have examined a related, monogamous species, the California mouse (Peromyscus californicus, where we predicted that males would be less sensitive to BPA in terms of navigational and exploratory behaviors, while displaying other traits related to interactions with females and territorial marking that might be vulnerable to disruption. As in the deer mouse experiments, females were fed either a phytoestrogen-free CTL diet through pregnancy and lactation or the same diet supplemented with BPA (50 mg/kg feed weight or ethinyl estradiol (EE (0.1 part per billion to provide a "pure" estrogen control. After weaning, pups were maintained on CTL diet until they had reached sexual maturity, at which time behaviors were evaluated. In addition, territorial marking was assessed in BPA-exposed males housed alone and when a control male was visible in the testing arena. In contrast to deer mice, BPA and EE exposure had no effect on spatial navigational skills in either male or female California mice. While CTL females exhibited greater exploratory behavior than CTL males, BPA exposure abolished this sex difference. BPA-exposed males, however, engaged in less territorial marking when CTL males were present. These studies demonstrate that developmental BPA exposure can disrupt adult behaviors in a sex- and species-dependent manner and are consistent with the hypothesis that sexually selected traits are particularly vulnerable to endocrine disruption and should be a

Leading Edge Asynchronous Propeller (LEAPTech) Distributed Electric Propulsion (DEP) Concept

Data.gov (United States)

National Aeronautics and Space Administration — The "Semi-Tandem Electric Distributed Wing Zip Aviation Advanced Concept Project" was renamed to LEAPTech DEP to better align with the content of the work. This...

Generation IV concepts - Presentation at ACRS workshop 'Regulatory challenges for future nuclear power plants'

International Nuclear Information System (INIS)

Versluis, Rob M.

2001-01-01

The concept of the Near-Term Deployment Working Group was to define a technical approach for Generation IV system with enough detail to allow evaluation against the goal, bur broad enough to allow for optional features and trade. The following concepts were taken into account: water coolant (water or heavy water), gas coolant, liquid metal coolants. Concepts were grouped according to concept sets of technology base share and design approach. Water coolant concepts were grouped as follows: PWR loop reactors, integral primary system PWRs, Integral BWRs, pressure tube reactors, high conversion cores, supercritical water reactors, advanced fuel cycle concepts. Gas coolant concepts were grouped as follows: pebble bed modular reactors; prismatic modular reactors, very high temperature reactors, fast spectrum reactors, others (fluidized bed, moving ignition zone concept). Liquid metal concepts were grouped in four major categories: Medium-to-large oxide-fueled systems; Medium-sized metal-fueled systems; Medium-sized Pb/Pb-Bi systems; Small-sized Pb/Pb-Bi systems. The three supporting technology areas were examined: Fuels (oxide, metal, nitride); Coolants (Na, Pb/Pb-Bi); Fuel Cycle (advanced aqueous, pyroprocess). Non-classical concepts were also grouped as follows: Eutectic metallic fuel; Molten salt fuel; Gas core reactor; Molten salt cooled/solid fuel; Organic cooled reactor; Solid conduction/heat pipe; Fission product direct energy conversion. The Technical working Groups are analyzing the candidate concepts for performance potential relative to the goals; and technology gaps

Advanced calculus

CERN Document Server

Fitzpatrick, Patrick M

2009-01-01

Advanced Calculus is intended as a text for courses that furnish the backbone of the student's undergraduate education in mathematical analysis. The goal is to rigorously present the fundamental concepts within the context of illuminating examples and stimulating exercises. This book is self-contained and starts with the creation of basic tools using the completeness axiom. The continuity, differentiability, integrability, and power series representation properties of functions of a single variable are established. The next few chapters describe the topological and metric properties of Euclide

Advanced SOA tools and applications

CERN Document Server

Brzezinski, Jerzy; Cellary, Wojciech; Grzech, Adam; Zielinski, Krzysztof

2014-01-01

This book presents advanced software development tools for construction, deployment and governance of Service Oriented Architecture (SOA) applications. Novel technical concepts and paradigms, formulated during the research stage and during development of such tools are presented and illustrated by practical usage examples. Hence this book will be of interest not only to theoreticians but also to engineers who cope with real-life problems. Additionally, each chapter contains an overview of related work, enabling comparison of the proposed concepts with exiting solutions in various areas of the SOA development process. This makes the book interesting also for students and scientists who investigate similar issues.

Molten salt reactor concept

International Nuclear Information System (INIS)

Sood, D.D.

1980-01-01

Molten salt reactor is an advanced breeder concept which is suited for the utilization of thorium for nuclear power production. This reactor is based on the use of solutions of uranium or plutonium fluorides in LiF-BeF 2 -ThF 4 as fuel. Unlike the conventional reactors, no external coolant is used in the reactor core and the fuel salt itself is circulated through heat exchangers to transfer the fission produced heat to a secondary salt (NaF-NaBF 4 ) for steam generation. A part of the fuel stream is continuously processed to isolate 233 Pa, so that it can decay to fissile 233 U without getting converted to 234 Pa, and for the removal of neutron absorbing fission products. This on-line processing scheme makes this reactor concept to achieve a breeding ratio of 1.07 which is the highest for any thermal breeder reactor. Experimental studies at the Bhabha Atomic Research Centre, Bombay, have established the use of plutonium as fuel for this reactor. This molten salt reactor concept is described and the work conducted at the Bhabha Atomic Research Centre is summarised. (auth.)

Advances in solar sailing

CERN Document Server

Third International Symposium on Solar Sailing

2014-01-01

Hosted by the Advanced Space Concepts Laboratory within the department of Mechanical and Aerospace Engineering of the University of Strathclyde, the third International Symposium on Solar Sailing was held in McCance Building at 16 Richmond Street, Glasgow, between 11 and 13 June 2013. The symposium attracted over 90 delegates from19 different counties, bringing together international experts from across the globe to discuss funded solar sail flight programs alongside on-going technology development and testing programs. The symposium also provided a forum for the discussion of enabling technologies, new application concepts, materials and structural concepts, space environmental effects, dynamics, navigation, control, and much more. This volume contains the unabridged symposium proceedings, in the gathered experts own words. As symposium chair, I thank our partners at Scottish Enterprise and L’Garde, Inc., the symposium’s gold sponsor, for their support in realising this symposium.

Angle Concept: A High School and Tertiary Longitudinal Perspective to Minimize Obstacles

Science.gov (United States)

Barabash, Marita

2017-01-01

The concept of angle emerges in numerous forms as the learning of mathematics and its applications advances through the high school and tertiary curriculum. Many difficulties and misconceptions in the usage of this multifaceted concept might be avoided or at least minimized should the lecturers in different areas of pure and applied mathematics be…

CURRENT CONCEPTS IN ACL RECONSTRUCTION

Directory of Open Access Journals (Sweden)

Freddie H. Fu

2008-09-01

Full Text Available Current Concepts in ACL Reconstruction is a complete reference text composed of the most thorough collection of topics on the ACL and its surgical reconstruction compiled, with contributions from some of the world's experts and most experienced ACL surgeons. Various procedures mentioned throughout the text are also demonstrated in an accompanying video CD-ROM. PURPOSE Composing a single, comprehensive and complete information source on ACL including basic sciences, clinical issues, latest concepts and surgical techniques, from evaluation to outcome, from history to future, editors and contributors have targeted to keep the audience pace with the latest concepts and techniques for the evaluation and the treatment of ACL injuries. FEATURES The text is composed of 27 chapters in 6 sections. The first section is mostly about basic sciences, also history of the ACL, imaging, clinical approach to adolescent and pediatric patients are subjected. In the second section, Graft Choices and Arthroscopy Portals for ACL Reconstruction are mentioned. The third section is about the technique and the outcome of the single-bundle ACL reconstruction. The fourth chapter includes the techniques and outcome of the double-bundle ACL reconstruction. In the fifth chapter revision, navigation technology, rehabilitation and the evaluation of the outcome of ACL reconstruction is subjected. The sixth/the last chapter is about the future advances to reach: What We Have Learned and the Future of ACL Reconstruction. AUDIENCE Orthopedic residents, sports traumatology and knee surgery fellows, orthopedic surgeons, also scientists in basic sciences or clinicians who are studying or planning a research on ACL forms the audience group of this book. ASSESSMENT This is the latest, the most complete and comprehensive textbook of ACL reconstruction produced by the editorial work up of two pioneer and masters "Freddie H. Fu MD and Steven B. Cohen MD" with the contribution of world

Feasibility study of ultra-long life fast reactor core concept - 028

International Nuclear Information System (INIS)

Kim, T.K.; Taiwo, T.A.

2010-01-01

An ultra-long life core concept is proposed targeting capital and operational cost reductions and ultra-high discharge burnup in a fast reactor system. The core concept is achieved by de-rating the power density and adopting annular core geometry to maintain criticality for more than 40 years without refueling. The ultra-long life core has a specific power of ∼10 MW/t and an average driver fuel discharge burnup of ∼300 GWd/t. It is assumed such ultra-high burnup fuel can be developed within an advanced fuel cycle program. Several benefits are expected from the ultra-long life core concept such as capital and operational cost reductions, low proliferation risk, and effectively holding LWR spent fuel without disposal until technologies for a closed nuclear fuel cycle are developed and deployed. As future work, safety analysis, development of the advanced core cooling methods, and comparative cost analysis are expected. (authors)

Sustainability of evidence-based healthcare: research agenda, methodological advances, and infrastructure support.

Science.gov (United States)

Proctor, Enola; Luke, Douglas; Calhoun, Annaliese; McMillen, Curtis; Brownson, Ross; McCrary, Stacey; Padek, Margaret

2015-06-11

Little is known about how well or under what conditions health innovations are sustained and their gains maintained once they are put into practice. Implementation science typically focuses on uptake by early adopters of one healthcare innovation at a time. The later-stage challenges of scaling up and sustaining evidence-supported interventions receive too little attention. This project identifies the challenges associated with sustainability research and generates recommendations for accelerating and strengthening this work. A multi-method, multi-stage approach, was used: (1) identifying and recruiting experts in sustainability as participants, (2) conducting research on sustainability using concept mapping, (3) action planning during an intensive working conference of sustainability experts to expand the concept mapping quantitative results, and (4) consolidating results into a set of recommendations for research, methodological advances, and infrastructure building to advance understanding of sustainability. Participants comprised researchers, funders, and leaders in health, mental health, and public health with shared interest in the sustainability of evidence-based health care. Prompted to identify important issues for sustainability research, participants generated 91 distinct statements, for which a concept mapping process produced 11 conceptually distinct clusters. During the conference, participants built upon the concept mapping clusters to generate recommendations for sustainability research. The recommendations fell into three domains: (1) pursue high priority research questions as a unified agenda on sustainability; (2) advance methods for sustainability research; (3) advance infrastructure to support sustainability research. Implementation science needs to pursue later-stage translation research questions required for population impact. Priorities include conceptual consistency and operational clarity for measuring sustainability, developing evidence

Assessment of nonbackfittable concepts for improving uranium utilization in LWRs

International Nuclear Information System (INIS)

Newman, D.F.; Goldsmith, S.; Fleischman, R.M.

1980-01-01

Recent efforts to improve uranium utilization in light water reactors (LWRs) have involved backfittable changes to fuel or operations. The Advanced Reactor Design Study sponsored by the US Department of Energy identified and evaluated nonbackfittable LWR concepts to provide a basis for selecting and demonstrating specific improvements that have good implementation potential. Because the application of nonbackfittable concepts necessitates modifications to contemporary reactor designs, it was apparent that the most qualified organizations to assess implementation potential would be LWR designers/vendors. Accordingly, Babcock and Wilcox, Combustion Engineering, and General Electric were the principal participants in selecting, assessing, and evaluating the nonbackfittable concepts included in this study. The results of the industrial assessments of nonbackfittable LWR concepts are shown

Competencies in Organizational E-Learning: Concepts and Tools

Science.gov (United States)

Sicilia, Miguel-Angel, Ed.

2007-01-01

"Competencies in Organizational E-Learning: Concepts and Tools" provides a comprehensive view of the way competencies can be used to drive organizational e-learning, including the main conceptual elements, competency gap analysis, advanced related computing topics, the application of semantic Web technologies, and the integration of competencies…

Solar Electric Propulsion Concepts for Human Space Exploration

Science.gov (United States)

Mercer, Carolyn R.; Mcguire, Melissa L.; Oleson, Steven R.; Barrett, Michael J.

2016-01-01

Advances in solar array and electric thruster technologies now offer the promise of new, very capable space transportation systems that will allow us to cost effectively explore the solar system. NASA has developed numerous solar electric propulsion spacecraft concepts with power levels ranging from tens to hundreds of kilowatts for robotic and piloted missions to asteroids and Mars. This paper describes nine electric and hybrid solar electric/chemical propulsion concepts developed over the last 5 years and discusses how they might be used for human exploration of the inner solar system.

Advance Noise Control Fan II: Test Rig Fan Risk Management Study

Science.gov (United States)

Lucero, John

2013-01-01

Since 1995 the Advanced Noise Control Fan (ANCF) has significantly contributed to the advancement of the understanding of the physics of fan tonal noise generation. The 9'x15' WT has successfully tested multiple high speed fan designs over the last several decades. This advanced several tone noise reduction concepts to higher TRL and the validation of fan tone noise prediction codes.

Identification of a C-type lectin with antiviral and antibacterial activity from pacific white shrimp Litopenaeus vannamei.

Science.gov (United States)

Li, Ming; Li, Chaozheng; Ma, Chunxia; Li, Haoyang; Zuo, Hongliang; Weng, Shaoping; Chen, Xiaohan; Zeng, Digang; He, Jianguo; Xu, Xiaopeng

2014-10-01

C-type lectins (CTLs) play crucial roles in innate immune responses in invertebrates by recognizing and eliminating microinvaders. In this study, a CTL from pacific white shrimp Litopenaeus vannamei (LvCTL3) was identified. LvCTL3 contains a single C-type lectin-like domain (CTLD), which shows similarities to those of other shrimp CTLs and has a mutated 'EPD' motif in Ca(2+)-binding site 2. LvCTL3 mRNA can be detected in all tested tissues and expression of LvCTL3 in gills was up-regulated after Lipopolysaccharides, poly (I:C), Vibrio parahaemolyticus and white spot syndrome virus (WSSV) challenges, suggesting activation responses of LvCTL3 to bacterial, virus and immune stimulant challenges. The 5'flanking regulatory region of LvCTL3 was cloned and we identified a NF-κB binding motif in the LvCTL3 promoter region. Dual-luciferase reporter assays indicated that over-expression of L. vannamei dorsal can dramatically up regulate the promoter activity of LvCTL3, suggesting that LvCTL3 expression could be regulated through NF-κB signaling pathway. As far as we know, this is the first report on signaling pathway involve in shrimp CTLs expression. The recombinant LvCTL3 protein was expressed in Escherichia coli and purified by Ni-affinity chromatography. The purified LvCTL3 can agglutinate Gram-negative microbe Vibrio alginolyticus and V. parahaemolyticus and Gram-positive bacteria Bacillus subtilis in the presence of calcium ions, but cannot agglutinate Gram-positive bacteria Streptococcus agalactiae. The agglutination activity of LvCTL3 was abolished when Ca(2+) was chelated with EDTA, suggesting the function of LvCTL3 is Ca(2+)-dependent. In vivo challenge experiments showed that the recombinant LvCTL3 protein can significantly reduce the mortalities of V. parahemolyticus and WSSV infection, indicating LvCTL3 might play significant roles in shrimp innate immunity defense against bacterial and viral infection. Copyright © 2014 Elsevier Ltd. All rights reserved.

Recent advances and design options of the aseismic bearing pad concept for reduction of seismic loading

International Nuclear Information System (INIS)

Vaidya, N.R.; Musacchio, J.M.; Rizzo, P.C.

1985-01-01

The intent of this paper is to: briefly review the developed concepts from a mechanics standpoint; summarize the results of recent testing and applications; discuss the complexities and subtleties of differences between concepts, and highlight the effectiveness of each within selected frequency ranges. On this basis, the paper will provide a forum for application of each concept within the nuclear design community. The potential licensing implications of incorporating the ABP concept into nuclear plant design are be discussed in light of actual experience extrapolated to several dominant regulatory processes; namely the French, German, Japanese, Canadian and American. The intent is to identify potential licensing issues, spur additional research and development in these areas, and continue to bring the concept to the attention of the nuclear community to facilitate acceptance and application. (orig./HP)

Generic repository design concepts and thermal analysis (FY11)

International Nuclear Information System (INIS)

Howard, Robert; Dupont, Mark; Blink, James A.; Fratoni, Massimiliano; Greenberg, Harris; Carter, Joe; Hardin, Ernest L.; Sutton, Mark A.

2011-01-01

Reference concepts for geologic disposal of used nuclear fuel and high-level radioactive waste in the U.S. are developed, including geologic settings and engineered barriers. Repository thermal analysis is demonstrated for a range of waste types from projected future, advanced nuclear fuel cycles. The results show significant differences among geologic media considered (clay/shale, crystalline rock, salt), and also that waste package size and waste loading must be limited to meet targeted maximum temperature values. In this study, the UFD R and D Campaign has developed a set of reference geologic disposal concepts for a range of waste types that could potentially be generated in advanced nuclear FCs. A disposal concept consists of three components: waste inventory, geologic setting, and concept of operations. Mature repository concepts have been developed in other countries for disposal of spent LWR fuel and HLW from reprocessing UNF, and these serve as starting points for developing this set. Additional design details and EBS concepts will be considered as the reference disposal concepts evolve. The waste inventory considered in this study includes: (1) direct disposal of SNF from the LWR fleet, including Gen III+ advanced LWRs being developed through the Nuclear Power 2010 Program, operating in a once-through cycle; (2) waste generated from reprocessing of LWR UOX UNF to recover U and Pu, and subsequent direct disposal of used Pu-MOX fuel (also used in LWRs) in a modified-open cycle; and (3) waste generated by continuous recycling of metal fuel from fast reactors operating in a TRU burner configuration, with additional TRU material input supplied from reprocessing of LWR UOX fuel. The geologic setting provides the natural barriers, and establishes the boundary conditions for performance of engineered barriers. The composition and physical properties of the host medium dictate design and construction approaches, and determine hydrologic and thermal responses of

Generic repository design concepts and thermal analysis (FY11).

Energy Technology Data Exchange (ETDEWEB)

Howard, Robert (Oak Ridge National Laboratory, Oak Ridge, TN); Dupont, Mark (Savannah River Nuclear Solutions, Aiken, SC); Blink, James A. (Lawrence Livermore National Laboratory, Livermore, CA); Fratoni, Massimiliano (Lawrence Livermore National Laboratory, Livermore, CA); Greenberg, Harris (Lawrence Livermore National Laboratory, Livermore, CA); Carter, Joe (Savannah River Nuclear Solutions, Aiken, SC); Hardin, Ernest L.; Sutton, Mark A. (Lawrence Livermore National Laboratory, Livermore, CA)

2011-08-01

Reference concepts for geologic disposal of used nuclear fuel and high-level radioactive waste in the U.S. are developed, including geologic settings and engineered barriers. Repository thermal analysis is demonstrated for a range of waste types from projected future, advanced nuclear fuel cycles. The results show significant differences among geologic media considered (clay/shale, crystalline rock, salt), and also that waste package size and waste loading must be limited to meet targeted maximum temperature values. In this study, the UFD R&D Campaign has developed a set of reference geologic disposal concepts for a range of waste types that could potentially be generated in advanced nuclear FCs. A disposal concept consists of three components: waste inventory, geologic setting, and concept of operations. Mature repository concepts have been developed in other countries for disposal of spent LWR fuel and HLW from reprocessing UNF, and these serve as starting points for developing this set. Additional design details and EBS concepts will be considered as the reference disposal concepts evolve. The waste inventory considered in this study includes: (1) direct disposal of SNF from the LWR fleet, including Gen III+ advanced LWRs being developed through the Nuclear Power 2010 Program, operating in a once-through cycle; (2) waste generated from reprocessing of LWR UOX UNF to recover U and Pu, and subsequent direct disposal of used Pu-MOX fuel (also used in LWRs) in a modified-open cycle; and (3) waste generated by continuous recycling of metal fuel from fast reactors operating in a TRU burner configuration, with additional TRU material input supplied from reprocessing of LWR UOX fuel. The geologic setting provides the natural barriers, and establishes the boundary conditions for performance of engineered barriers. The composition and physical properties of the host medium dictate design and construction approaches, and determine hydrologic and thermal responses of the

The bacterial tubulin FtsZ requires its intrinsically disordered linker to direct robust cell wall construction.

Science.gov (United States)

Sundararajan, Kousik; Miguel, Amanda; Desmarais, Samantha M; Meier, Elizabeth L; Casey Huang, Kerwyn; Goley, Erin D

2015-06-23

The bacterial GTPase FtsZ forms a cytokinetic ring at midcell, recruits the division machinery and orchestrates membrane and peptidoglycan cell wall invagination. However, the mechanism for FtsZ regulation of peptidoglycan metabolism is unknown. The FtsZ GTPase domain is separated from its membrane-anchoring C-terminal conserved (CTC) peptide by a disordered C-terminal linker (CTL). Here we investigate CTL function in Caulobacter crescentus. Strikingly, production of FtsZ lacking the CTL (ΔCTL) is lethal: cells become filamentous, form envelope bulges and lyse, resembling treatment with β-lactam antibiotics. This phenotype is produced by FtsZ polymers bearing the CTC and a CTL shorter than 14 residues. Peptidoglycan synthesis still occurs downstream of ΔCTL; however, cells expressing ΔCTL exhibit reduced peptidoglycan crosslinking and longer glycan strands than wild type. Importantly, midcell proteins are still recruited to sites of ΔCTL assembly. We propose that FtsZ regulates peptidoglycan metabolism through a CTL-dependent mechanism that extends beyond simple protein recruitment.

Image and laparoscopic guided interstitial brachytherapy for locally advanced primary or recurrent gynaecological cancer using the adaptive GEC ESTRO target concept

International Nuclear Information System (INIS)

Fokdal, Lars; Tanderup, Kari; Nielsen, Soren Kynde; Christensen, Henrik Kidmose; Rohl, Lisbeth; Pedersen, Erik Morre; Schonemann, Niels Kim; Lindegaard, Jacob Christian

2011-01-01

Purpose: To retrospectively assess treatment outcome of image and laparoscopic guided interstitial pulsed dose rate brachytherapy (PDR-BT) for locally advanced gynaecological cancer using the adaptive GEC ESTRO target concept. Materials and methods: Between June 2005 and December 2010, 28 consecutive patients were treated for locally advanced primary vaginal (nine), recurrent endometrial (12) or recurrent cervical cancer (seven) with combined external beam radiotherapy (EBRT) and interstitial PDR-BT. Treatment was initiated with whole pelvic EBRT to a median dose of 45 Gy followed by PDR-BT using the Martinez Universal Perineal Interstitial Template (MUPIT). All implants were virtually preplanned using MRI of the pelvis with a dummy MUPIT in situ. The GEC ESTRO high risk clinical target volume (HR CTV), intermediate risk clinical target volume (IR CTV) and the organs at risk (OAR) were contoured and a preplan for implantation was generated (BrachyVision, Varian). The subsequent implantation was performed under laparoscopic visualisation. Final contouring and treatment planning were done using a post-implant CT. Planning aim of PDR-BT was to deliver 30 Gy in 50 hourly pulses to HR CTV. Manual dose optimisation was performed with the aim of reaching a D90 > 80 Gy in the HR CTV calculated as the total biologically equivalent to 2 Gy fractions of EBRT and BT (EQD2). Dose to the OAR were evaluated using dose volume constraints for D 2cc of 90 Gy for bladder and 70 Gy for rectum and sigmoid. Results: For HR CTV the median volume was 26 cm 3 (7-91 cm 3 ). Coverage of the HR CTV was 97% (90-100%) and D90 was 82 Gy (77-88 Gy). The D 2cc for bladder, rectum, and sigmoid were 65 Gy (47-81 Gy), 61 Gy (50-77 Gy), and 52 Gy (44-68 Gy), respectively. Median follow up was 18 months (6-61 months). The actuarial 2 years local control rate was 92% (SE 5), while disease-free survival and overall survival were 59% (SE 11) and 74%, respectively (SE 10). No complications to the

US long distance fiber optic networks: Technology, evolution and advanced concepts. Volume 2: Fiber optic technology and long distance networks

Science.gov (United States)

1986-10-01

The study projects until 2000 the evolution of long distance fiber optic networks in the U.S. Volume 1 is the Executive Summary. Volume 2 focuses on fiber optic components and systems that are directly related to the operation of long-haul networks. Optimistic, pessimistic and most likely scenarios of technology development are presented. The activities of national and regional companies implementing fiber long haul networks are also highlighted, along with an analysis of the market and regulatory forces affecting network evolution. Volume 3 presents advanced fiber optic network concept definitions. Inter-LATA traffic is quantified and forms the basis for the construction of 11-, 15-, 17-, and 23-node networks. Using the technology projections from Volume 2, a financial model identifies cost drivers and determines circuit mile costs between any two LATAs. A comparison of fiber optics with alternative transmission concludes the report.

The concept of neurosis in a cross-cultural perspective.

Science.gov (United States)

Chaturvedi, Santosh Kumar; Bhugra, Dinesh

2007-01-01

The aim of this review is to discuss the current state of research on the concept of neurosis across cultures and to document the advances made in this field over the previous year. There has been a significant alteration in the concept of neurosis in most cultures, with the relative abandonment of the term 'neurosis' and replacing the concept with that of common mental disorders. The state of research on the aetiopathogenesis of neurosis has moved towards neurobiological, neurophysiological and genetic factors. Neuroticism as a personality trait has retained its role in the development of neurotic disorders. The epidemiological studies on neurotic disorders are equivocal across cultures. Besides, studies on clinical presentation of common mental disorders, somatization and abnormal illness behaviour show some cultural variations. Though there are no significant advances in the management of neurosis equivalents, it seems that the specific serotonin receptor inhibitors may have a role in management of these conditions. The recent literature shows acceptance of common mental disorders across cultures replacing neurotic disorders. Other conceptual equivalents of neurosis are seen in somatoform disorders, somatization and abnormal illness behaviour. Some traditional culture-bound neurotic syndromes and idioms of distress persist.

Deep Space Habitat Concept Demonstrator

Science.gov (United States)

Bookout, Paul S.; Smitherman, David

2015-01-01

This project will develop, integrate, test, and evaluate Habitation Systems that will be utilized as technology testbeds and will advance NASA's understanding of alternative deep space mission architectures, requirements, and operations concepts. Rapid prototyping and existing hardware will be utilized to develop full-scale habitat demonstrators. FY 2014 focused on the development of a large volume Space Launch System (SLS) class habitat (Skylab Gen 2) based on the SLS hydrogen tank components. Similar to the original Skylab, a tank section of the SLS rocket can be outfitted with a deep space habitat configuration and launched as a payload on an SLS rocket. This concept can be used to support extended stay at the Lunar Distant Retrograde Orbit to support the Asteroid Retrieval Mission and provide a habitat suitable for human missions to Mars.

Concepts for institutional arrangements for the nuclear fuel cycle

International Nuclear Information System (INIS)

1979-02-01

These concepts deal with establishing a framework for the analysis of institutional arrangements, with institutional arrangements under consideration in the working groups on fuel and heavy water availability, enrichment availability, assurances of long-term supply, reprocessing-plutonium handling-recycling, fast breeder reactors, spent fuel management, waste management and disposal, and advanced reactor concepts. The standardization of nuclear practices, joint commercial and development undertakings, nuclear supply assurances, developing a consensus in international nuclear co-operation, and settlements of disputes are treated

Advanced Telescope for High Energy Nuclear Astrophysics (ATHENA)

National Research Council Canada - National Science Library

Johnson, W. N; Dermer, C; Kroeger, R. A; Kurfess, J. D; Gehrels, N; Grindlay, J; Leising, M. D; Prince, T; Purcell, W; Ryan, J; Tumer, T

1995-01-01

We present a space mission concept for a low energy gamma-ray telescope, ATHENA, which is under investigation as the next major advance in gamma-ray spectroscopy following the current COMPTON Gamma...

Advance Organizers and Examining of their Usage in 9th Grade Chemistry Textbooks

OpenAIRE

Canan NAKİBOĞLU; Nihan KAŞMER; Cem GÜLTEKİN; Füsun DÖNMEZ

2010-01-01

An advance organizer is the tool that is presented prior to the material to be learned, and that helps learners to organize and interpret new incoming information. In this study, a concept map concerning the classification of advance organizer was developed. Then, 9th grade chemistry textbooks written according to both current (year 2007) and past (year 1996) high school chemistry curriculum were examined by taking into account the concept map prepared. Next, the findings of each textbook ana...

The effect of an outdoor setting on the transfer of earth science concepts

Science.gov (United States)

Simmons, Jerry Marvin

The ability of students to transfer concepts learned in school to future learning and employment settings is critical to their academic and career success. Concept transfer can best be studied by defining it as a process rather than an isolated event. Preparation for future learning (PFL) is a process definition of transfer which recognizes the student's ability to draw from past experiences, make assumptions, and generate potential questions and strategies for problem resolution. The purpose of this study was to use the PFL definition of concept transfer to examine whether a knowledge-rich outdoor setting better prepares students for future learning of science concepts than the classroom setting alone does. The research hypothesis was that sixth-grade students experiencing a geology-rich outdoor setting would be better prepared to learn advanced earth science concepts than students experiencing classroom learning only. A quasi-experimental research design was used for this study on two non-equivalent, self-contained sixth-grade rural public school classes. After a pretest was given on prior geology knowledge, the outdoor treatment group was taken on a geology-rich field excursion which introduced them to the concepts of mineral formation and mining. The indoor treatment group received exposure to the same concepts in the classroom setting via color slides and identification of mineral specimens. Subsequently, both groups received direct instruction on advanced concepts about mineral formation and mining. They were then given a posttest, which presented the students with a problem-solving scenario and questions related to concepts covered in the direct instruction. A t-test done on pretest data revealed that the indoor treatment group had previously learned classroom geology material significantly better than the outdoor treatment group had. Therefore an analysis of covariance was performed on posttest data which showed that the outdoor treatment group was better

Pengaruh Advance Organizer Berbasis Proyek Terhadap Kemampuan Analisis – Sintesis Siswa

Directory of Open Access Journals (Sweden)

Tasiwan -

2014-01-01

Full Text Available Penelitian ini dilakukan untuk mengetahui pengaruh model pengatur kemajuan (advance organizer berbasis proyek terhadap kemampuan analisis – sintesis siswa pada konsep Energi. Sebelum pembelajaran, diberikan tugas proyek pada siswa untuk merealisasikan bel listrik sederhana, rangkaian arus seri - paralel, dan tuas. Produk proyek digunakan sebagai advance organizer dalam pembelajaran di kelas. Penguatan kognitif dilakukan melalui diskusi kelompok dan pembuatan peta konsep, ekspositori guru di kelas, dan kegiatan eksperimen laboratorium. Data diambil melalui pretest, post test, observasi partisipatif pembelajaran oleh dua orang observer, penilaian produk, peta konsep dan laporan kegiatan eksperimen. Teknik analisis data meliputi uji prasyarat data dan uji hipotesis Hasil penelitian menunjukkan bahwa siswa mengalami peningkatan kemampuan analisis – sintesis dalam aspek menguraikan, mengkategorikan, mengidentifikasi, merumuskan pernyataan, merekonstruksi, menentukan konsep, dan menganalisis konsep dengan rata – rata peningkatan delta skor sebesar 54,46 %, uji t sebesar 6,4, dan skala gain sebesar 0,3. This study was conducted to determine the effect of project-based advance organizer model on student’s analysis - synthesis ability of the energy concept. Students were given an assignment to realize the project on simple electric bell, the series – parallel circuit, and lever, before learning. The products of project were used as an advanced organizer in the learning activity. Cognitive strengthening was done through group discussions and concept mapping, expository learning in the classroom, and laboratory experiments activities. The data were taken through a pretest, post-test, participant observation study by two observers, product assessment, concept maps and report of experiment activities. Results showed that the students’ analysis - synthesis ability increased in the aspect of describing, categorizing, identifying, statement

Evolving concepts of heredity and genetics in orthodontics.

Science.gov (United States)

Carlson, David S

2015-12-01

The field of genetics emerged from the study of heredity early in the 20th century. Since that time, genetics has progressed through a series of defined eras based on a number of major conceptual and technical advances. Orthodontics also progressed through a series of conceptual stages over the past 100 years based in part on the ongoing and often circular debate about the relative importance of heredity (nature) and the local environment (nurture) in the etiology and treatment of malocclusion and dentofacial deformities. During the past 20 years, significant advancements in understanding the genomic basis of craniofacial development and the gene variants associated with dentofacial deformities have resulted in a convergence of the principles and concepts in genetics and in orthodontics that will lead to significant advancement of orthodontic treatments. Fundamental concepts from genetics and applied translational research in orthodontics provide a foundation for a new emphasis on precision orthodontics, which will establish a modern genomic basis for major improvements in the treatment of malocclusion and dentofacial deformities as well as many other areas of concern to orthodontists through the assessment of gene variants on a patient-by-patient basis. Copyright © 2015 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

Freight advanced traveler information system : functional requirements.

Science.gov (United States)

2012-08-01

This report describes the System Requirement Specifications (SyRS) for a Freight Advanced Traveler Information System : (FRATIS). The SyRS is based on user needs described in the FRATIS Concept of Operations (ConOps), which cover the essential : func...

Advanced concept for a crewed mission to the martian moons

Science.gov (United States)

Conte, Davide; Di Carlo, Marilena; Budzyń, Dorota; Burgoyne, Hayden; Fries, Dan; Grulich, Maria; Heizmann, Sören; Jethani, Henna; Lapôtre, Mathieu; Roos, Tobias; Castillo, Encarnación Serrano; Schermann, Marcel; Vieceli, Rhiannon; Wilson, Lee; Wynard, Christopher

2017-10-01

This paper presents the conceptual design of the IMaGInE (Innovative Mars Global International Exploration) Mission. The mission's objectives are to deliver a crew of four astronauts to the surface of Deimos and perform a robotic exploration mission to Phobos. Over the course of the 343 day mission during the years 2031 and 2032, the crew will perform surface excursions, technology demonstrations, In Situ Resource Utilization (ISRU) of the Martian moons, as well as site reconnaissance for future human exploration of Mars. This mission design makes use of an innovative hybrid propulsion concept (chemical and electric) to deliver a relatively low-mass reusable crewed spacecraft (approximately 100 mt) to cis-martian space. The crew makes use of torpor which minimizes launch payload mass. Green technologies are proposed as a stepping stone towards minimum environmental impact space access. The usage of beamed energy to power a grid of decentralized science stations is introduced, allowing for large scale characterization of the Martian environment. The low-thrust outbound and inbound trajectories are computed through the use of a direct method and a multiple shooting algorithm that considers various thrust and coast sequences to arrive at the final body with zero relative velocity. It is shown that the entire mission is rooted within the current NASA technology roadmap, ongoing scientific investments and feasible with an extrapolated NASA Budget. The presented mission won the 2016 Revolutionary Aerospace Systems Concepts - Academic Linkage (RASC-AL) competition.

UPAYA PENINGKATAN KEAKTIFAN DAN HASIL BELAJAR MATEMATIKAMELALUI PENDEKATAN CONTEXTUAL TEACHING AND LEARNING (CTL BERBANTUAN ALAT PERAGA PADA SISWA KELAS 5 SDN LODOYONG 03 – AMBARAWA TAHUN PELAJARAN 2013/2014

Directory of Open Access Journals (Sweden)

Nova Dinda Taurina

2015-12-01

Full Text Available Penelitian ini didasarkan pada kenyataan bahwa guru kurang optimal dalam pembelajaran matematika. Metode pembelajaran yang sering digunakan adalah ceramah, dan guru tidak menggunakan alat peraga dalam pembelajaran. Hal tersebut menyebabkan rendahnya keaktifan siswa dan berdampak pada rendahnya hasil belajar mereka. Sebanyak 62% atau 13 siswa dari 21 siswa tidak dapat mencapai nilai ≥ KKM sebesar 70. Berdasar dari permasalahan tersebut, maka penelitian ini bertujuan untuk meningkatkan keaktifan dan hasil belajar matematika pada siswa kelas 5 SDN Lodoyong 03 Kecamatan Ambarawa Tahun Pelajaran 2013/2014 melalui pendekatan CTL berbantuan alat peraga. Jenis penelitian ini adalah penelitian tindakan kelas atau PTK. Model PTK yang digunakan adalah model Kemmis dan Taggart yang terdiri dari empat tahapan yaitu tahap perencanaan, pelaksanaan, observasi, dan refleksi. Adapun yang menjadi subyek penelitian ini adalah siswa kelas 5 SDN Lodoyong 03 berjumlah 21 siswa, yang terdiri dari 14 siswa laki-laki dan 7 siswa perempuan. Teknik pengumpulan data menggunakan teknik tes, observasi, wawancara dan dokumentasi. Instrumen penelitiannya berupa lembar evaluasi berbentuk isian dan uraian, lembar observasi aktivitas guru dan siswa, serta lembar wawancara guru dan siswa. Indikator keberhasilan penelitian ini sebesar 80% atau sekitar 17 siswa harus mencapai nilai ≥ KKM sebesar 70 dan harus aktif dalam pembelajaran. Adapun teknik analisis data yang digunakan adalah analisis ketuntasan dan analisis komparatif. Hasil penelitian menunjukkan adanya peningkatan hasil belajar siswa. Pada pra siklus hanya 8 siswa (38% yang tuntas dan 13 siswa lainnya (62% belum tuntas. Pada siklus I jumlah siswa yang tuntas meningkat menjadi 13 siswa (62%, sedangkan 8 siswa (38% belum tuntas. Kemudian pada siklus II meningkat lagi menjadi 17 siswa (81% yang tuntas, dan hanya 4 siswa (19% yang belum tuntas. Hal tersebut berarti bahwa penelitian ini berhasil, karena telah mencapai

Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.

Directory of Open Access Journals (Sweden)

Morgane Rolland

Full Text Available BACKGROUND: While human immunodeficiency virus type 1 (HIV-1-specific cytotoxic T lymphocytes preferentially target specific regions of the viral proteome, HIV-1 features that contribute to immune recognition are not well understood. One hypothesis is that similarities between HIV and human proteins influence the host immune response, i.e., resemblance between viral and host peptides could preclude reactivity against certain HIV epitopes. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the extent of similarity between HIV-1 and the human proteome. Proteins from the HIV-1 B consensus sequence from 2001 were dissected into overlapping k-mers, which were then probed against a non-redundant database of the human proteome in order to identify segments of high similarity. We tested the relationship between HIV-1 similarity to host encoded peptides and immune recognition in HIV-infected individuals, and found that HIV immunogenicity could be partially modulated by the sequence similarity to the host proteome. ELISpot responses to peptides spanning the entire viral proteome evaluated in 314 individuals showed a trend indicating an inverse relationship between the similarity to the host proteome and the frequency of recognition. In addition, analysis of responses by a group of 30 HIV-infected individuals against 944 overlapping peptides representing a broad range of individual HIV-1B Nef variants, affirmed that the degree of similarity to the host was significantly lower for peptides with reactive epitopes than for those that were not recognized. CONCLUSIONS/SIGNIFICANCE: Our results suggest that antigenic motifs that are scarcely represented in human proteins might represent more immunogenic CTL targets not selected against in the host. This observation could provide guidance in the design of more effective HIV immunogens, as sequences devoid of host-like features might afford superior immune reactivity.

Advanced energy projects FY 1997 research summaries

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-09-01

The mission of the Advanced Energy Projects (AEP) program is to explore the scientific feasibility of novel energy-related concepts that are high risk, in terms of scientific feasibility, yet have a realistic potential for a high technological payoff. The concepts supported by the AEP are typically at an early stage of scientific development. They often arise from advances in basic research and are premature for consideration by applied research or technology development programs. Some are based on discoveries of new scientific phenomena or involve exploratory ideas that span multiple scientific and technical disciplines which do not fit into an existing DOE program area. In all cases, the objective is to support evaluation of the scientific or technical feasibility of the novel concepts involved. Following AEP support, it is expected that each concept will be sufficiently developed to attract further funding from other sources to realize its full potential. Projects that involve evolutionary research or technology development and demonstration are not supported by AEP. Furthermore, research projects more appropriate for another existing DOE research program are not encouraged. There were 65 projects in the AEP research portfolio during Fiscal Year 1997. Eigheen projects were initiated during that fiscal year. This document consists of short summaries of projects active in FY 1997. Further information of a specific project may be obtained by contacting the principal investigator.

Priorities for Advancing the Concept of New Ruralism

Directory of Open Access Journals (Sweden)

Galen Newman

2016-03-01

Full Text Available Civic expansion and land use migrations to urban peripheries can accelerate the conversion of agricultural land uses. Widespread trepidation concerning urban sprawl has led to innovative frameworks for conserving or enhancing farmland. New Ruralism is one such framework, linking farmland preservation with developmental plans to reduce farmland conversion and low density development. Although the concept is still evolving, recent support for New Ruralism has grown. One of the most important factors in creating a New Ruralism-based development is coherent policy for permanent agricultural preserves. These preserves require the simultaneous, careful planning of land preservation balanced with the location of future development. This paper discusses the current condition of farmland loss and reviews issues and challenges associated with farmland preservation with existing New Ruralism developments. The goal is to synthesize this information into recommendations for increasing farmland preservation opportunities in New Ruralism-based developments. A more comprehensive definition for New Ruralism is presented, accompanied by several priorities for maximizing the economic, environmental, and cultural viability of New Ruralism-based farmland preserves.

Advanced information processing system

Science.gov (United States)

Lala, J. H.

1984-01-01

Design and performance details of the advanced information processing system (AIPS) for fault and damage tolerant data processing on aircraft and spacecraft are presented. AIPS comprises several computers distributed throughout the vehicle and linked by a damage tolerant data bus. Most I/O functions are available to all the computers, which run in a TDMA mode. Each computer performs separate specific tasks in normal operation and assumes other tasks in degraded modes. Redundant software assures that all fault monitoring, logging and reporting are automated, together with control functions. Redundant duplex links and damage-spread limitation provide the fault tolerance. Details of an advanced design of a laboratory-scale proof-of-concept system are described, including functional operations.

A concept analysis of professional commitment in nursing.

Science.gov (United States)

García-Moyano, Loreto; Altisent, Rogelio; Pellicer-García, Begoña; Guerrero-Portillo, Sandra; Arrazola-Alberdi, Oihana; Delgado-Marroquín, María Teresa

2017-01-01

The concept of professional commitment is being widely studied at present. However, although it is considered an indicator for the most human part of nursing care, there is no clear definition for it, and different descriptors are being used indiscriminately to reference it. The aim of this study is to clarify the concept of professional commitment in nursing through the Rodgers' evolutionary concept analysis process. Systematic search using English and Spanish descriptors and concept analysis. Studies published between 2009 and June 2015, front-to-back analysis of the Nursing Ethics journal and manual check of articles cited in studies related to the Nijmegen Professionalism Scale. The procedure of concept analysis developed by Rodgers was used. Ethical considerations: Although the topic was not labeled as sensitive and subject to ethical approval, its realization was approved by the Ethical Committee of Clinical Research of Aragon (CEICA) approved the study on 18 March 2015 and also careful procedures have been followed according to ethics expressed in the Declaration of Helsinki. A total of 17 published studies. A clear definition of the concept was made, and surrogate terms, concept dimension, differential factors related to the concept, sociocultural variations and consequences for nursing practice were identified. There is a need for continuous advancement in the development of the concept, specific actions to encourage this and the improvement of evaluation methods for its study.

Conceptual definition of a technology development mission for advanced solar dynamic power systems

Science.gov (United States)

Migra, R. P.

1986-01-01

An initial conceptual definition of a technology development mission for advanced solar dynamic power systems is provided, utilizing a space station to provide a dedicated test facility. The advanced power systems considered included Brayton, Stirling, and liquid metal Rankine systems operating in the temperature range of 1040 to 1400 K. The critical technologies for advanced systems were identified by reviewing the current state of the art of solar dynamic power systems. The experimental requirements were determined by planning a system test of a 20 kWe solar dynamic power system on the space station test facility. These requirements were documented via the Mission Requirements Working Group (MRWG) and Technology Development Advocacy Group (TDAG) forms. Various concepts or considerations of advanced concepts are discussed. A preliminary evolutionary plan for this technology development mission was prepared.

HLA-A2–Restricted Cytotoxic T Lymphocyte Epitopes from Human Heparanase as Novel Targets for Broad-Spectrum Tumor Immunotherapy

Directory of Open Access Journals (Sweden)

Ting Chen

2008-09-01

Full Text Available Peptide vaccination for cancer immunotherapy requires identification of peptide epitopes derived from antigenic proteins associated with tumors. Heparanase (Hpa is broadly expressed in various advanced tumors and seems to be an attractive new tumor-associated antigen. The present study was designed to predict and identify HLA-A2– restricted cytotoxic T lymphocyte (CTL epitopes in the protein of human Hpa. For this purpose, HLA-A2–restricted CTL epitopes were identified using the following four-step procedure: 1 a computer-based epitope prediction from the amino acid sequence of human Hpa, 2 a peptide-binding assay to determine the affinity of the predicted protein with the HLA-A2 molecule, 3 stimulation of the primary T-cell response against the predicted peptides in vitro, and 4 testing of the induced CTLs toward different kinds of carcinoma cells expressing Hpa antigens and/or HLA-A2. The results demonstrated that, of the tested peptides, effectors induced by peptides of human Hpa containing residues 525-533 (PAFSYSFFV, Hpa525, 277-285 (KMLKSFLKA, Hpa277, and 405-413 (WLSLLFKKL, Hpa405 could effectively lyse various tumor cell lines that were Hpa-positive and HLA-A2-matched. We also found that these peptide-specific CTLs could not lyse autologous lymphocytes with low Hpa activity. Further study revealed that Hpa525, Hpa277, and Hpa405 peptides increased the frequency of IFN-γ–producing T cells compared to a negative peptide. Our results suggest that Hpa525, Hpa277, and Hpa405 peptides are new HLA-A2–restricted CTL epitopes capable of inducing Hpa-specific CTLs in vitro. Because Hpa is expressed in most advanced malignant tumors, Hpa525, Hpa277, and Hpa405 peptide–based vaccines may be useful for the immunotherapy for patients with advanced tumors.

Advanced thorium cycles in LWRs and HWRs

International Nuclear Information System (INIS)

Radkowsky, A.

The main aspects of advanced thorium cycles in LWRs and HWRs are reviewed. New concepts include the seed blanket close packed heavy water breeder, the light water seed blanket thorium burner and self-induced thorium cycle in CANDU type reactors. (author)

Concept definition of KT-2, a large-aspect-ratio diverter tokamak with FWCD

Energy Technology Data Exchange (ETDEWEB)

Kim, Sung Kyoo; Chang, In Soon; Chung, Moon Kyoo; Hwang, Chul Kyoo; Lee, Kwang Won; In, Sang Ryul; Choi, Byung Ho; Hong, Bong Keun; Oh, Byung Hoon; Chung, Seung Ho; Yoon, Byung Joo; Yoon, Jae Sung; Song, Woo Sub [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Chang, Choong Suk; Chang, Hong Yung; Choi, Duk In; Nam, Chang Heui [Korea Advanced Inst. of Science and Technology, Taejon (Korea, Republic of); Chung, Kyoo Sun [Hanyang Univ., Seoul (Korea, Republic of); Hong, Sang Heui [Seoul National Univ., Seoul (Korea, Republic of); Kang, Heui Dong [Kyungpook National Univ., Taegu (Korea, Republic of); Lee, Jae Koo [Pohang Inst. of Science and Technology, Kyungnam (Korea, Republic of)

1994-11-01

A concept definition of the KT-2 tokamak is made. The research goal of the machine is to study the `advanced tokamak` physics and engineering issues on the mid size large-aspect-ratio diverter tokamak with intense RF heating (>5 MW). Survey of the status of the research fields, the physics basis for the concept, operation scenarios, as well as machine design concept are presented. (Author) 86 refs., 17 figs., 22 tabs.

Concept definition of KT-2, a large-aspect-ratio diverter tokamak with FWCD

International Nuclear Information System (INIS)

Kim, Sung Kyoo; Chang, In Soon; Chung, Moon Kyoo; Hwang, Chul Kyoo; Lee, Kwang Won; In, Sang Ryul; Choi, Byung Ho; Hong, Bong Keun; Oh, Byung Hoon; Chung, Seung Ho; Yoon, Byung Joo; Yoon, Jae Sung; Song, Woo Sub; Chang, Choong Suk; Chang, Hong Yung; Choi, Duk In; Nam, Chang Heui; Chung, Kyoo Sun; Hong, Sang Heui; Kang, Heui Dong; Lee, Jae Koo

1994-11-01

A concept definition of the KT-2 tokamak is made. The research goal of the machine is to study the 'advanced tokamak' physics and engineering issues on the mid size large-aspect-ratio diverter tokamak with intense RF heating (>5 MW). Survey of the status of the research fields, the physics basis for the concept, operation scenarios, as well as machine design concept are presented. (Author) 86 refs., 17 figs., 22 tabs

Additive manufacturing for freeform mechatronics design: from concepts to applications

NARCIS (Netherlands)

Baars, G. van; Smeltink, J.; Werff, J. van der; Limpens, M.; Barink, M.; Berg, D. van den; Vreugd, J. de; Witvoet, G.; Galaktionov, O.S.

2015-01-01

This article presents developments of freeform mechatronics concepts, enabled by industrial Additive Manufacturing (AM), aiming at breakthroughs for precision engineering challenges such as lightweight, advanced thermal control, and integrated design. To assess potential impact in future

Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction

DEFF Research Database (Denmark)

Larsen, Mette Voldby; Lundegaard, Claus; Lamberth, K.

2007-01-01

BACKGROUND: Reliable predictions of Cytotoxic T lymphocyte (CTL) epitopes are essential for rational vaccine design. Most importantly, they can minimize the experimental effort needed to identify epitopes. NetCTL is a web-based tool designed for predicting human CTL epitopes in any given protein....... of the other methods achieved a sensitivity of 0.64. The NetCTL-1.2 method is available at http://www.cbs.dtu.dk/services/NetCTL.All used datasets are available at http://www.cbs.dtu.dk/suppl/immunology/CTL-1.2.php....

Integral fast reactor concept inherent safety features

International Nuclear Information System (INIS)

Marchaterre, J.F.; Sevy, R.H.; Cahalan, J.E.