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Sample records for ctl advanced concept

  1. Advanced concepts for acceleration

    International Nuclear Information System (INIS)

    Keefe, D.

    1986-07-01

    Selected examples of advanced accelerator concepts are reviewed. Such plasma accelerators as plasma beat wave accelerator, plasma wake field accelerator, and plasma grating accelerator are discussed particularly as examples of concepts for accelerating relativistic electrons or positrons. Also covered are the pulsed electron-beam, pulsed laser accelerator, inverse Cherenkov accelerator, inverse free-electron laser, switched radial-line accelerators, and two-beam accelerator. Advanced concepts for ion acceleration discussed include the electron ring accelerator, excitation of waves on intense electron beams, and two-wave combinations

  2. Resistance mutations and CTL epitopes in archived HIV-1 DNA of patients on antiviral treatment: toward a new concept of vaccine.

    Directory of Open Access Journals (Sweden)

    Jennifer Papuchon

    Full Text Available Eleven patients responding successfully to first-line antiretroviral therapy (ART were investigated for proviral drug resistance mutations (DRMs in RT by ultra-deep pyrosequencing (UDPS. After molecular typing of the class I alleles A and B, the CTL epitopes in the Gag, Nef and Pol regions of the provirus were sequenced and compared to the reference HXB2 HIV-1 epitopes. They were then matched with the HLA alleles with determination of theoretical affinity (TA. For 3 patients, the results could be compared with an RNA sample of the circulating virus at initiation of therapy. Five out of 11 patients exhibited DRMs by UDPS. The issue is whether a therapeutic switch is relevant in these patients by taking into account the identity of the archived resistance mutations. When the archived CTL epitopes were determined on the basis of the HLA alleles, different patterns were observed. Some epitopes were identical to those reported for the reference with the same TA, while others were mutated with a decrease in TA. In 2 cases, an epitope was observed as a combination of subpopulations at entry and was retrieved as a single population with lower TA at success. With regard to immunological stimulation and given the variability of the archived CTL epitopes, we propose a new concept of curative vaccine based on identification of HIV-1 CTL epitopes after prior sequencing of proviral DNA and matching with HLA class I alleles.

  3. Advanced microwave processing concepts

    Energy Technology Data Exchange (ETDEWEB)

    Lauf, R.J.; McMillan, A.D.; Paulauskas, F.L. [Oak Ridge National Laboratory, TN (United States)

    1995-05-01

    The purpose of this work is to explore the feasibility of several advanced microwave processing concepts to develop new energy-efficient materials and processes. The project includes two tasks: (1) commercialization of the variable-frequency microwave furnace; and (2) microwave curing of polymer composites. The variable frequency microwave furnace, whose initial conception and design was funded by the AIC Materials Program, will allow us, for the first time, to conduct microwave processing studies over a wide frequency range. This novel design uses a high-power traveling wave tube (TWT) originally developed for electronic warfare. By using this microwave source, one can not only select individual microwave frequencies for particular experiments, but also achieve uniform power densities over a large area by the superposition of many different frequencies. Microwave curing of thermoset resins will be studied because it hold the potential of in-situ curing of continuous-fiber composites for strong, lightweight components. Microwave heating can shorten curing times, provided issues of scaleup, uniformity, and thermal management can be adequately addressed.

  4. ADVANCED SULFUR CONTROL CONCEPTS

    Energy Technology Data Exchange (ETDEWEB)

    Apostolos A. Nikolopoulos; Santosh K. Gangwal; William J. McMichael; Jeffrey W. Portzer

    2003-01-01

    Conventional sulfur removal in integrated gasification combined cycle (IGCC) power plants involves numerous steps: COS (carbonyl sulfide) hydrolysis, amine scrubbing/regeneration, Claus process, and tail-gas treatment. Advanced sulfur removal in IGCC systems involves typically the use of zinc oxide-based sorbents. The sulfides sorbent is regenerated using dilute air to produce a dilute SO{sub 2} (sulfur dioxide) tail gas. Under previous contracts the highly effective first generation Direct Sulfur Recovery Process (DSRP) for catalytic reduction of this SO{sub 2} tail gas to elemental sulfur was developed. This process is currently undergoing field-testing. In this project, advanced concepts were evaluated to reduce the number of unit operations in sulfur removal and recovery. Substantial effort was directed towards developing sorbents that could be directly regenerated to elemental sulfur in an Advanced Hot Gas Process (AHGP). Development of this process has been described in detail in Appendices A-F. RTI began the development of the Single-step Sulfur Recovery Process (SSRP) to eliminate the use of sorbents and multiple reactors in sulfur removal and recovery. This process showed promising preliminary results and thus further process development of AHGP was abandoned in favor of SSRP. The SSRP is a direct Claus process that consists of injecting SO{sub 2} directly into the quenched coal gas from a coal gasifier, and reacting the H{sub 2}S-SO{sub 2} mixture over a selective catalyst to both remove and recover sulfur in a single step. The process is conducted at gasifier pressure and 125 to 160 C. The proposed commercial embodiment of the SSRP involves a liquid phase of molten sulfur with dispersed catalyst in a slurry bubble-column reactor (SBCR).

  5. Advanced fusion concepts program

    International Nuclear Information System (INIS)

    Dove, W.F.

    1978-01-01

    While the prospects for the eventual development of a tokamak-based fusion reactor appear promising at the present time, the Department of Energy maintains a vigorous program in alternate magnetic fusion concepts. Several of the concepts presently supported include the toroidal reversed field pinch, Tormac, Elmo Bumpy Torus, and various linear options. Recent technical accomplishments and program evaluations indicate that the possibility now exists for undertaking the next development stage, a proof-of-principle experiment, for a few of the most promising alternate concepts

  6. Advanced Welding Concepts

    Science.gov (United States)

    Ding, Robert J.

    2010-01-01

    Four advanced welding techniques and their use in NASA are briefly reviewed in this poster presentation. The welding techniques reviewed are: Solid State Welding, Friction Stir Welding (FSW), Thermal Stir Welding (TSW) and Ultrasonic Stir Welding.

  7. Progress in advanced accelerator concepts

    International Nuclear Information System (INIS)

    Sessler, A.M.

    1994-08-01

    A review is given of recent progress in this field, drawing heavily upon material presented at the Workshop on Advanced Accelerator Concepts, The Abbey, June 12--18, 1994. Attention is addressed to (1) plasma based concepts, (2) photo-cathodes, (3) radio frequency sources and Two-Beam Accelerators, (4) near and far-field schemes (including collective accelerators), (5) beam handling and conditioning, and (6) exotic collider concepts (such as photon colliders and muon colliders)

  8. Advanced divertor concepts

    International Nuclear Information System (INIS)

    Ohyabu, N.; Komori, A.; Sagara, A.; Suzuki, H.; Morisaki, T.; Masuzaki, S.; Watanabe, T.; Noda, N.; Motojima, O.

    1996-01-01

    LHD divertor development program has generated various innovative divertor concepts and technologies which will help to improve the plasma performance in both helical and tokamak devices. They are two divertor operational scenarios (confinement improvement by generating high temperature divertor plasma and simultaneous achievement of radiative cooling and H-mode-like confinement improvement). Local island divertor geometry has also been proposed. This new divertor has been successfully tested in the CHS device and is planned to be installed in the LHD device. In addition, technological development of new efficient hydrogen pumping schemes (carbon sheet pump and membrane pump) are being pursued for enhancement of the divertor control capability. 17 refs., 8 figs

  9. Advanced Concepts. Chapter 21

    Science.gov (United States)

    Johnson, Les; Mulqueen, Jack

    2013-01-01

    Before there is a funded space mission, there must be a present need for the mission. Space science and exploration are expensive, and without a well-defined and justifiable need, no one is going to commit significant funding for any space endeavor. However, as discussed in Chapter 1, applications of space technology and many and broad, hence there are many ways to determine and establish a mission need. Robotic science missions are justified by their science return. To be selected for flight, questions like these must be addressed: What is the science question that needs answering, and will the proposed mission be the most cost-effective way to answer it? Why does answering the question require an expensive space flight, instead of some ground-based alternative? If the question can only be answered by flying in space, then why is this approach better than other potential approaches? How much will it cost? And is the technology required to answer the question in hand and ready to use? If not, then how much will it cost and how long will it take to mature the technology to a usable level? There are also many ways to justify human exploration missions, including science return, technology advancement, as well as intangible reasons, such as national pride. Nonetheless, many of the questions that need answering, are similar to those for robotic science missions: Where are the people going, why, and will the proposed mission be the most cost-effective way to get there? What is the safest method to achieve the goal? How much will it cost? And is the technology required to get there and keep the crew alive in hand and ready to use? If not, then how much will it cost and how long will it take to mature the technology to a usable level? Another reason for some groups sending spacecraft into space is for profit. Telecommunications, geospatial imaging, and tourism are examples of proven, market-driven space missions and applications. For this specific set of users, the

  10. The advanced MAPLE reactor concept

    International Nuclear Information System (INIS)

    Lidstone, R.F.; Lee, A.G.; Gillespie, G.E.; Smith, H.J.

    1989-01-01

    In Canada the need for advanced neutron sources has long been recognized. During the past several years Atomic Energy of Canada Limited (AECL) has been developing the new MAPLE multipurpose reactor concept. To date, the MAPLE program has focused on the development of a modest-cost multipurpose medium-flux neutron source to meet contemporary requirements for applied and basic research using neutron beams, for small-scale materials testing and analysis and for radioisotope production. The basic MAPLE concept incorporates a compact light-water cooled and moderated core within a heavy water primary reflector to generate strong neutron flux levels in a variety of irradiation facilities. In view of renewed Canadian interest in a high-flux neutron source, the MAPLE group has begun to explore advanced concepts based on AECL's experience with heavy water reactors. The overall objective is to define a high-flux facility that will support materials testing for advanced power reactors, new developments in extracted neutron-beam applications, and/or production of radioisotopes. The design target is to attain performance levels of HFR-Grenoble, HFBR, HFIR in a new heavy water-cooled, -moderated,-reflected reactor based on rodded LEU fuel. Physics, shielding, and thermohydraulic studies have been performed for the MAPLE heavy water reactor. 14 refs., 4 figs., 1 tab

  11. The advanced MAPLE reactor concept

    International Nuclear Information System (INIS)

    Lidstone, R.F.; Lee, A.G.; Gillespie, G.E.; Smith, H.J.

    1989-01-01

    High-flux neutron sources are continuing to be of interest both in Canada and internationally to support materials testing for advanced power reactors, new developments in extracted-neutron-beam applications, and commercial production of selected radioisotopes. The advanced MAPLE reactor concept has been developed to meet these needs. The advanced MAPLE reactor is a new tank-type D 2 O reactor that uses rodded low-enrichment uranium fuel in a compact annular core to generate peak thermal-neutron fluxes of 1 x 10 19 n·s -1 in a central irradiation rig with a thermal power output of 50 MW. Capital and incremental development costs are minimized by using MAPLE reactor technology to the greatest extent practicable

  12. Advanced fusion concepts: project summaries

    International Nuclear Information System (INIS)

    1980-12-01

    This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, US Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications. Information is given for each of the following programs: (1) reverse-field pinch, (2) compact toroid, (3) alternate fuel/multipoles, (4) stellarator/torsatron, (5) linear magnetic fusion, (6) liners, and (7) Tormac

  13. Advancing Uncertainty: Untangling and Discerning Related Concepts

    OpenAIRE

    Janice Penrod

    2002-01-01

    Methods of advancing concepts within the qualitative paradigm have been developed and articulated. In this section, I describe methodological perspectives of a project designed to advance the concept of uncertainty using multiple qualitative methods. Through a series of earlier studies, the concept of uncertainty arose repeatedly in varied contexts, working its way into prominence, and warranting further investigation. Processes of advanced concept analysis were used to initiate the formal in...

  14. Advanced Messaging Concept Development Basic Safety Message

    Data.gov (United States)

    Department of Transportation — Contains all Basic Safety Messages (BSMs) collected during the Advanced Messaging Concept Development (AMCD) field testing program. For this project, all of the Part...

  15. Seminar 'World CTL 2008'

    International Nuclear Information System (INIS)

    Chevalier, B.

    2008-01-01

    'Coal to liquid' (CTL) is a well known technic used since years especially by the Germans during the last world war and South Africa during the oil embargo. The combination of coal gasification and Fischer-Tropsch synthesis allows the production of synthetic diesel and gasoline. Nice alternative for those countries with large reserves of coal (China, South Africa, USA) which want to be more 'oil-free' in the long term, it faces however quite a lot of challenges: Very sophisticated technic, not yet proven for large scale of unit, high investment costs, necessity to add up CO 2 capture and storage (CCS) due to climate change constraints... In any cases this process seems more adequate and competitive to produce electricity and power than to focus on transportation fuels which are more easily manufactured from oil. (author)

  16. Advancing Uncertainty: Untangling and Discerning Related Concepts

    Directory of Open Access Journals (Sweden)

    Janice Penrod

    2002-12-01

    Full Text Available Methods of advancing concepts within the qualitative paradigm have been developed and articulated. In this section, I describe methodological perspectives of a project designed to advance the concept of uncertainty using multiple qualitative methods. Through a series of earlier studies, the concept of uncertainty arose repeatedly in varied contexts, working its way into prominence, and warranting further investigation. Processes of advanced concept analysis were used to initiate the formal investigation into the meaning of the concept. Through concept analysis, the concept was deconstructed to identify conceptual components and gaps in understanding. Using this skeletal framework of the concept identified through concept analysis, subsequent studies were carried out to add ‘flesh’ to the concept. First, a concept refinement using the literature as data was completed. Findings revealed that the current state of the concept of uncertainty failed to incorporate what was known of the lived experience. Therefore, using interview techniques as the primary data source, a phenomenological study of uncertainty among caregivers was conducted. Incorporating the findings of the phenomenology, the skeletal framework of the concept was further fleshed out using techniques of concept correction to produce a more mature conceptualization of uncertainty. In this section, I describe the flow of this qualitative project investigating the concept of uncertainty, with special emphasis on a particular threat to validity (called conceptual tunnel vision that was identified and addressed during the phases of concept correction. Though in this article I employ a study of uncertainty for illustration, limited substantive findings regarding uncertainty are presented to retain a clear focus on the methodological issues.

  17. Advanced reactor concepts and safety

    International Nuclear Information System (INIS)

    Lipsett, J.J.

    1988-06-01

    The need for some consistency in the terms used to describe the evolution of methods for ensuring the safety of nuclear reactors has been identified by the IAEA. This is timely since there appears to be a danger that the precision of many valuable words is being diluted and that a new jargon may appear that will confuse rather than aid the communication of important but possibly diverse philosophies and concepts. Among the difficulties faced by the nuclear industry is promoting and gaining a widespread understanding of the risks actually posed by nuclear reactors. In view of the importance of communication to both the public and to the technical community generally, the starting point for the definition of terms must be with dictionary meanings and common technical usage. The nuclear engineering community should use such words in conformance with the whole technical world. This paper addresses many of the issues suggested in the invitation to meet and also poses some additional issues for consideration. Some examples are the role of the operator in either enhancing or degrading safety and how the meaning or interpretation of the word 'safety' can be expected to change during the next few decades. It is advantageous to use criteria against which technologies and ongoing operating performance can be judged provided that the criteria are generic and not specific to particular reactor concepts. Some thoughts are offered on the need to frame the criteria carefully so that innovative solutions and concepts are fostered, not stifled

  18. Materials technologies for advanced nuclear energy concepts

    International Nuclear Information System (INIS)

    DiStefano, J.; Harms, B.

    1983-01-01

    High-performance, advanced nuclear power plant concepts have emerged with major emphasis on lower capital costs, inherent safety, and increased reliability. The materials problems posed by these concepts are discussed and how the scientists and technologists at ORNL plan to solve them is described

  19. The advanced MAPLE reactor concept

    International Nuclear Information System (INIS)

    Lidstone, R.F.; Lee, A.G.; Gillespie, G.E.; Smith, H.J.

    1989-01-01

    During the past several years, Atomic Energy of Canada Limited (AECL) has been developing the new MAPLE multipurpose reactor concept, which is capable of generating peak thermal neutron fluxes of up to 3 x 10 18 n/m 2 s in its heavy water reflector at a nominal thermal power level of 15MW. An assessment of the MAPLE-D 2 O reactor has shown that it could also be used as a high-flux neutron source. it could be developed to be used for several applications if a 12-site annular core is used. Thermal fluxes several times greater than in existing facilities would be available (author)

  20. Advanced PWR fuel design concepts

    International Nuclear Information System (INIS)

    Andersor, C.K.; Harris, R.P.; Crump, M.W.; Fuhrman, N.

    1987-01-01

    For nearly 15 years, Combustion Engineering has provided pressurized water reactor fuel with the features most suppliers are now introducing in their advanced fuel designs. Zircaloy grids, removable upper end fittings, large fission gas plenum, high burnup, integral burnable poisons and sophisticated analytical methods are all features of C-E standard fuel which have been well proven by reactor performance. C-E's next generation fuel for pressurized water reactors features 24-month operating cycles, optimal lattice burnable poisons, increased resistance to common industry fuel rod failure mechanisms, and hardware and methodology for operating margin improvements. Application of these various improvements offer continued improvement in fuel cycle economics, plant operation and maintenance. (author)

  1. Advanced midwifery practice: An evolutionary concept analysis.

    Science.gov (United States)

    Goemaes, Régine; Beeckman, Dimitri; Goossens, Joline; Shawe, Jill; Verhaeghe, Sofie; Van Hecke, Ann

    2016-11-01

    the concept of 'advanced midwifery practice' is explored to a limited extent in the international literature. However, a clear conception of advanced midwifery practice is vital to advance the discipline and to achieve both internal and external legitimacy. This concept analysis aims to clarify advanced midwifery practice and identify its components. a review of the literature was executed using Rodgers' evolutionary method of concept analysis to analyze the attributes, references, related terms, antecedents and consequences of advanced midwifery practice. an international consensus definition of advanced midwifery practice is currently lacking. Four major attributes of advanced midwife practitioners (AMPs) are identified: autonomy in practice, leadership, expertise, and research skills. A consensus was found on the need of preparation at master's level for AMPs. Such midwives have a broad and internationally varied scope of practice, fulfilling different roles such as clinicians, clinical and professional leaders, educators, consultants, managers, change agents, researchers, and auditors. Evidence illustrating the important part AMPs play on a clinical and strategic level is mounting. the findings of this concept analysis support a wide variety in the emergence, titles, roles, and scope of practice of AMPs. Research on clinical and strategic outcomes of care provided by AMPs supports further implementation of these roles. As the indistinctness of AMPs' titles and roles is one of the barriers for implementation, a clear conceptualization of advanced midwifery practice seems essential for successful implementation. an international debate and consensus on the defining elements of advanced midwifery practice could enhance the further development of midwifery as a profession and is a prerequisite for its successful implementation. Due to rising numbers of AMPs, extension of practice and elevated quality requirements in healthcare, more outcomes research exclusively

  2. Advanced Accelerator Concepts Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Wurtele, Jonathan S.

    2014-05-13

    A major focus of research supported by this Grant has been on the ALPHA antihydrogen trap. We first trapped antihydrogen in 2010 and soon thereafter demonstrated trapping for 1000s. We now have observed resonant quantum interactions with antihydrogen. These papers in Nature and Nature Physics report the major milestones in anti-atom trapping. The success was only achieved through careful work that advanced our understanding of collective dynamics in charged particle systems, the development of new cooling and diagnostics, and in- novation in understanding how to make physics measurements with small numbers of anti-atoms. This research included evaporative cooling, autoresonant excitation of longitudinal motion, and centrifugal separation. Antihydrogen trapping by ALPHA is progressing towards the point when a important theories believed by most to hold for all physical systems, such as CPT (Charge-Parity-Time) invariance and the Weak Equivalence Principle (matter and antimatter behaving the same way under the influence of gravity) can be directly tested in a new regime. One motivation for this test is that most accepted theories of the Big Bang predict that we should observe equal amounts of matter and antimatter. However astrophysicists have found very little antimatter in the universe. Our experiment will, if successful over the next seven years, provide a new test of these ideas. Many earlier detailed and beautiful tests have been made, but the trapping of neutral antimatter allows us to explore the possibility of direct, model-independent tests. Successful cooling of the anti atoms, careful limits on systematics and increased trapping rates, all planned for our follow-up experiment (ALPHA-II) will reach unrivaled precision. CPT invariance implies that the spectra of hydrogen and antihydrogen should be identical. Spectra can be measured in principle with great precision, and any di erences we might observe would revolutionize fundamental physics. This is the

  3. Advanced Fusion Concepts project summaries. FY 1983

    International Nuclear Information System (INIS)

    1983-06-01

    This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, US Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate studients, graduates, other professional staff, and recent publications. The individual project summaries are prepared by the principle investigators in collaboration with the Advanced Fusion Concepts (AFC) Branch. In addition to the project summaries, statements of branch objectives, and budget summaries are also provided

  4. Advanced fusion concepts project summaries: 1981

    International Nuclear Information System (INIS)

    1982-03-01

    This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, US Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications

  5. Advanced Fusion Concepts project summaries, FY 1982

    International Nuclear Information System (INIS)

    1982-10-01

    This report contains descriptions of the activities of all the projects supported by the Advanced Fusion Concepts Branch of the Office of Fusion Energy, U.S. Department of Energy. These descriptions are project summaries of each of the individual projects, and contain the following: title, principle investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications

  6. ADVANCED HIGH PERFORMANCE SOLID WALL BLANKET CONCEPTS

    International Nuclear Information System (INIS)

    WONG, CPC; MALANG, S; NISHIO, S; RAFFRAY, R; SAGARA, S

    2002-01-01

    OAK A271 ADVANCED HIGH PERFORMANCE SOLID WALL BLANKET CONCEPTS. First wall and blanket (FW/blanket) design is a crucial element in the performance and acceptance of a fusion power plant. High temperature structural and breeding materials are needed for high thermal performance. A suitable combination of structural design with the selected materials is necessary for D-T fuel sufficiency. Whenever possible, low afterheat, low chemical reactivity and low activation materials are desired to achieve passive safety and minimize the amount of high-level waste. Of course the selected fusion FW/blanket design will have to match the operational scenarios of high performance plasma. The key characteristics of eight advanced high performance FW/blanket concepts are presented in this paper. Design configurations, performance characteristics, unique advantages and issues are summarized. All reviewed designs can satisfy most of the necessary design goals. For further development, in concert with the advancement in plasma control and scrape off layer physics, additional emphasis will be needed in the areas of first wall coating material selection, design of plasma stabilization coils, consideration of reactor startup and transient events. To validate the projected performance of the advanced FW/blanket concepts the critical element is the need for 14 MeV neutron irradiation facilities for the generation of necessary engineering design data and the prediction of FW/blanket components lifetime and availability

  7. 2nd European Advanced Accelerator Concepts Workshop

    CERN Document Server

    Assmann, Ralph; Grebenyuk, Julia; EAAC 2015

    2016-01-01

    The European Advanced Accelerator Concepts Workshop has the mission to discuss and foster methods of beam acceleration with gradients beyond state of the art in operational facilities. The most cost effective and compact methods for generating high energy particle beams shall be reviewed and assessed. This includes diagnostics methods, timing technology, special need for injectors, beam matching, beam dynamics with advanced accelerators and development of adequate simulations. This workshop is organized in the context of the EU-funded European Network for Novel Accelerators (EuroNNAc2), that includes 52 Research Institutes and universities.

  8. Advanced fusion concepts project summaries, FY 1988

    International Nuclear Information System (INIS)

    1988-04-01

    This report summarizes all the projects supported by the Advanced Fusion Concepts Branch of the Applied Plasma Physics Division of the Office of Fusion Energy, US Department of Energy. Each project summary was written by the respective principal investigator using the format: title, principal investigators, funding levels, purpose, approach, progress, plans, milestones, graduate students, graduates, other professional staff, and recent publications. This report is organized into three sections: Section one contains five summaries describing work in the reversed-field pinch program being performed by a diversified group of contractors, these include a national laboratory, a private company, and several universities. Section two contains eight summaries of work from the compact toroid area which encompasses field-reversed configurations, spheromaks, and heating and formation experiments. Section three contains summaries from two other programs, a density Z-pinch experiment and high-beta Q machine experiment. The intent of this collection of project summaries is to help the contractors of the Advanced Fusion Concepts Branch understand their relationship with the rest of the branch's activities. It is also meant to provide background to those outside the program by showing the range of activities of interest of the Advanced Fusion Concepts Branch

  9. Penn State advanced light water reactor concept

    International Nuclear Information System (INIS)

    Borkowski, J.A.; Smith, K.A.; Edwards, R.M.; Robinson, G.E.; Schultz, M.A.; Klevans, E.H.

    1987-01-01

    The accident at Three Mile Island heightened concerns over the safety of nuclear power. In response to these concerns, a research group at the Pennsylvania State University (Penn State) undertook the conceptual design of an advanced light water reactor (ALWR) under sponsorship of the US Dept. of Energy (DOE). The design builds on the literally hundreds of years worth of experience with light water reactor technology. The concept is a reconfigured pressurized water reactor (PWR) with the capability of being shut down to a safe condition simply by removing all ac power, both off-site and on-site. Using additional passively activated heat sinks and replacing the pressurizer with a pressurizing pump system, the concept essentially eliminates the concerns of core damage associated with a total station blackout. Evaluation of the Penn State ALWR concept has been conducted using the EPRI Modular Modeling System (MMS). Results show that a superior response to normal operating transients can be achieved in comparison to the response with a conventional PWR pressurizer. The DOE-sponsored Penn State ALWR concept has evolved into a significant reconfiguration of a PWR leading to enhanced safety characteristics. The reconfiguration has touched a number of areas in overall plant design including a shutdown turbine in the secondary system, additional passively activated heat sinks, a unique primary side pressurizing concept, a low pressure cleanup system, reactor building layout, and a low power density core design

  10. Advanced high performance solid wall blanket concepts

    International Nuclear Information System (INIS)

    Wong, C.P.C.; Malang, S.; Nishio, S.; Raffray, R.; Sagara, A.

    2002-01-01

    First wall and blanket (FW/blanket) design is a crucial element in the performance and acceptance of a fusion power plant. High temperature structural and breeding materials are needed for high thermal performance. A suitable combination of structural design with the selected materials is necessary for D-T fuel sufficiency. Whenever possible, low afterheat, low chemical reactivity and low activation materials are desired to achieve passive safety and minimize the amount of high-level waste. Of course the selected fusion FW/blanket design will have to match the operational scenarios of high performance plasma. The key characteristics of eight advanced high performance FW/blanket concepts are presented in this paper. Design configurations, performance characteristics, unique advantages and issues are summarized. All reviewed designs can satisfy most of the necessary design goals. For further development, in concert with the advancement in plasma control and scrape off layer physics, additional emphasis will be needed in the areas of first wall coating material selection, design of plasma stabilization coils, consideration of reactor startup and transient events. To validate the projected performance of the advanced FW/blanket concepts the critical element is the need for 14 MeV neutron irradiation facilities for the generation of necessary engineering design data and the prediction of FW/blanket components lifetime and availability

  11. Safety criteria for advanced HTGR concepts

    International Nuclear Information System (INIS)

    Kroeger, W.

    1989-01-01

    It is commonly agreed that advanced HTGR concepts must be licensable, which means that they must fulfil existing regulatory requirements. Furthermore, it is necessary to improve their public acceptance and they must even be suitable for urban sites. Therefore, they should be 'safer' than existing plants, which mainly means with respect to low-frequency or beyond-design severe accidents. Last but not least, the realization of advanced HTGR would be easier if commonly shared safety principles could be stated ensuring this further increased level of safety internationally. These qualitative statements need to be cast into quantitative guidelines which can be used as a rationale for safety evaluation. This paper tries to describe the status reached and to stimulate international activities. (author). 12 refs, 4 figs, 3 tabs

  12. Advances in tracking and trigger concepts

    International Nuclear Information System (INIS)

    Kisel, Ivan

    2014-01-01

    Increasing beam intensities and input data rates require to rethink the traditional approaches in trigger concepts. At the same time the advanced many-core computer architectures providing new dimensions in programming require to rework the standard methods or to develop new methods of track reconstruction in order to efficiently use parallelism of the computer hardware. As a results a new tendency appears to replace the standard (usually implemented in FPGA) hardware triggers by clusters of computers running software reconstruction and selection algorithms. In addition that makes possible unification of the offline and on-line data processing and analysis in one software package running on a heterogeneous computer farm

  13. Wnt signaling inhibits CTL memory programming.

    Science.gov (United States)

    Xiao, Zhengguo; Sun, Zhifeng; Smyth, Kendra; Li, Lei

    2013-12-01

    Induction of functional CTLs is one of the major goals for vaccine development and cancer therapy. Inflammatory cytokines are critical for memory CTL generation. Wnt signaling is important for CTL priming and memory formation, but its role in cytokine-driven memory CTL programming is unclear. We found that wnt signaling inhibited IL-12-driven CTL activation and memory programming. This impaired memory CTL programming was attributed to up-regulation of eomes and down-regulation of T-bet. Wnt signaling suppressed the mTOR pathway during CTL activation, which was different to its effects on other cell types. Interestingly, the impaired memory CTL programming by wnt was partially rescued by mTOR inhibitor rapamycin. In conclusion, we found that crosstalk between wnt and the IL-12 signaling inhibits T-bet and mTOR pathways and impairs memory programming which can be recovered in part by rapamycin. In addition, direct inhibition of wnt signaling during CTL activation does not affect CTL memory programming. Therefore, wnt signaling may serve as a new tool for CTL manipulation in autoimmune diseases and immune therapy for certain cancers. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Advanced High Voltage Power Device Concepts

    CERN Document Server

    Baliga, B Jayant

    2012-01-01

    Advanced High Voltage Power Device Concepts describes devices utilized in power transmission and distribution equipment, and for very high power motor control in electric trains and steel-mills. Since these devices must be capable of supporting more than 5000-volts in the blocking mode, this books covers operation of devices rated at 5,000-V, 10,000-V and 20,000-V. Advanced concepts (the MCT, the BRT, and the EST) that enable MOS-gated control of power thyristor structures are described and analyzed in detail. In addition, detailed analyses of the silicon IGBT, as well as the silicon carbide MOSFET and IGBT, are provided for comparison purposes. Throughout the book, analytical models are generated to give a better understanding of the physics of operation for all the structures. This book provides readers with: The first comprehensive treatment of high voltage (over 5000-volts) power devices suitable for the power distribution, traction, and motor-control markets;  Analytical formulations for all the device ...

  15. Technology and applications of advanced accelerator concepts

    CERN Document Server

    Chou, Weiren

    2016-01-01

    Since its invention in the 1920s, particle accelerators have made tremendous progress in accelerator science, technology and applications. However, the fundamental acceleration principle, namely, to apply an external radiofrequency (RF) electric field to accelerate charged particles, remains unchanged. As this method (either room temperature RF or superconducting RF) is approaching its intrinsic limitation in acceleration gradient (measured in MeV/m), it becomes apparent that new methods with much higher acceleration gradient (measured in GeV/m) must be found for future very high energy accelerators as well as future compact (table-top or room-size) accelerators. This volume introduces a number of advanced accelerator concepts (AAC) — their principles, technologies and potential applications. For the time being, none of them stands out as a definitive direction in which to go. But these novel ideas are in hot pursuit and look promising. Furthermore, some AAC requires a high power laser system. This has the ...

  16. ULTRA SCWR+: Practical advanced water reactor concepts

    International Nuclear Information System (INIS)

    Duffey, Romney; Khartabil, Hussam; Kuran, Sermet; Zhou, Tracy; Pioro, Igor

    2008-01-01

    Modern thermal power plants now utilize supercritical steam cycles with thermal efficiencies of over 45%. Recent developments have lead to Ultra-SuperCritical (USC) systems, which adopt reheat turbines that can attain efficiencies of over 50%. Because these turbines are already developed, demonstrated and deployed worldwide, and use existing and traditional steam cycle technology, the simplest nuclear advance is to utilize these proven thermal cycle conditions by coupling this turbine type to a reactor. This development direction is fundamentally counter to the usual approach of adopting high-temperature gas-cooled (helium-cooled) reactor cycles, for which turbines have yet to be demonstrated on commercial scale unlike the supercritical steam turbines. The ULTRA (Ultra-supercritical Light water Thermal ReActor) SCWR+ concept adopts the fundamental design approach of matching a water and steam-cooled reactor to the ultra-supercritical steam cycle, adopting the existing and planned thermal power plant turbines. The HP and IP sections are fed with conditions of 25 MPa/625degC and 7 MPa/700degC, respectively, to achieve operating plant thermal efficiencies in excess of 50%, with a direct turbine cycle. By using such low-pressure reheated steam, this concept also adopts technology that was explored and used many years ago in existing water reactors, with the potential to produce large quantities of low cost heat, which can be used for other industrial and district processes. Pressure-Tube (PT) reactors are suitable for adoption of this design approach and, in addition, have other advantages that will significantly improve water-cooled reactor technology. These additional advantages include enhanced safety and improved resource utilization and proliferation resistance. This paper describes the PT-SCWR+ concept and its potential enhancements. (author)

  17. Introduction to Advanced Engine Control Concepts

    Science.gov (United States)

    Sanjay, Garg

    2007-01-01

    With the increased emphasis on aircraft safety, enhanced performance and affordability, and the need to reduce the environmental impact of aircraft, there are many new challenges being faced by the designers of aircraft propulsion systems. The Controls and Dynamics Branch at NASA (National Aeronautics and Space Administration) Glenn Research Center (GRC) in Cleveland, Ohio, is leading and participating in various projects in partnership with other organizations within GRC and across NASA, the U.S. aerospace industry, and academia to develop advanced controls and health management technologies that will help meet these challenges through the concept of Intelligent Propulsion Systems. The key enabling technologies for an Intelligent Propulsion System are the increased efficiencies of components through active control, advanced diagnostics and prognostics integrated with intelligent engine control to enhance operational reliability and component life, and distributed control with smart sensors and actuators in an adaptive fault tolerant architecture. This presentation describes the current activities of the Controls and Dynamics Branch in the areas of active component control and propulsion system intelligent control, and presents some recent analytical and experimental results in these areas.

  18. Advances and Evolving Concepts in Allergic Asthma.

    Science.gov (United States)

    Tung, Hui-Ying; Li, Evan; Landers, Cameron; Nguyen, An; Kheradmand, Farrah; Knight, J Morgan; Corry, David B

    2018-02-01

    Allergic asthma is a heterogeneous disorder that defies a unanimously acceptable definition, but is generally recognized through its highly characteristic clinical expression of dyspnea and cough accompanied by clinical data that document reversible or exaggerated airway constriction and obstruction. The generally rising prevalence of asthma in highly industrialized societies despite significant therapeutic advances suggests that the fundamental cause(s) of asthma remain poorly understood. Detailed analyses of both the indoor (built) and outdoor environments continue to support the concept that not only inhaled particulates, especially carbon-based particulate pollution, pollens, and fungal elements, but also many noxious gases and chemicals, especially biologically derived byproducts such as proteinases, are essential to asthma pathogenesis. Phthalates, another common class of chemical pollutant found in the built environment, are emerging as potentially important mediators or attenuators of asthma. Other biological products such as endotoxin have also been confirmed to be protective in both the indoor and outdoor contexts. Proasthmatic factors are believed to activate, and in some instances initiate, pathologic inflammatory cascades through complex interactions with pattern recognition receptors (PRRs) expressed on many cell types, but especially airway epithelial cells. PRRs initiate the release of proallergic cytokines such as interleukin (IL)-33, IL-25, and others that coordinate activation of innate lymphoid cells type 2 (ILC2), T helper type 2 cells, and immunoglobulin E-secreting B cells that together promote additional inflammation and the major airway remodeling events (airway hyperresponsiveness, mucus hypersecretion) that promote airway obstruction. Proteinases, with airway fungi and viruses being potentially important sources, are emerging as critically important initiators of these inflammatory cascades in part through their effects on clotting

  19. Advanced Concept Architecture Design and Integrated Analysis (ACADIA)

    Science.gov (United States)

    2017-11-03

    1 Advanced Concept Architecture Design and Integrated Analysis (ACADIA) Submitted to the National Institute of Aerospace (NIA) on...Research Report 20161001 - 20161030 Advanced Concept Architecture Design and Integrated Analysis (ACADIA) W911NF-16-2-0229 8504Cedric Justin, Youngjun

  20. Advanced concepts in the United States fusion program

    International Nuclear Information System (INIS)

    Dove, W.F.

    1985-01-01

    The goal of the magnetic fusion program is to establish the scientific and technological base for fusion energy. Development of a variety of magnetic confinement systems is essential to achieving that goal. The role of the advanced concepts program is to conduct experimental investigations of confinement concepts other than the tokamaks and tandem mirror concepts. The present advanced concepts program consists of the reversed-field-pinch (RFP), the spheromak and the field-reversed configuration (FRC). Significant new experiments in the RFP and FRC concepts have been approved and are described

  1. Advanced Wind Turbine Drivetrain Concepts. Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-12-01

    This report presents key findings from the Department of Energy’s Advanced Drivetrain Workshop, held on June 29-30, 2010, to assess different advanced drivetrain technologies, their relative potential to improve the state-of-the-art in wind turbine drivetrains, and the scope of research and development needed for their commercialization in wind turbine applications.

  2. Nonproliferation characteristics of advanced fuel cycle concepts

    International Nuclear Information System (INIS)

    Persiani, P.J.

    1998-01-01

    The purpose of this study is to comment on the proliferation characteristic profiles of some of the proposed fuel cycle alternatives to help ensure that nonproliferation concerns are introduced into the early stages of a fuel cycle concept development program, and to perhaps aid in the more effective implementation of the international nonproliferation regime initiatives and safeguards methods and systems. Alternative cycle concepts proposed by several countries involve the recycle of spent fuel without the separation of plutonium from uranium and fission products

  3. Test Concept for Advanced Oxidation Techniques

    DEFF Research Database (Denmark)

    Bennedsen, Lars Rønn; Søgaard, Erik Gydesen; Mortensen, Lars

    advanced on-site oxidation tests. The remediation techniques included are electrochemical oxidation, photochemical/photocatalytic oxidation, ozone, hydrogen peroxide, permanganate, and persulfate among others. A versatile construction of the mobile test unit makes it possible to combine different...

  4. The concept of advanced radiographic practice: An international perspective

    International Nuclear Information System (INIS)

    Hardy, Maryann; Legg, Jeffrey; Smith, Tony; Ween, Borgny; Williams, Imelda; Motto, Jenny

    2008-01-01

    Advanced radiographic practice has been the focus of much discussion and debate over the last decade, not only in the United Kingdom where advanced practitioner roles are now recognised within the national career framework, but also internationally. Yet, despite almost simultaneous professional movement towards advanced radiographic practice philosophy and ideals in many countries, international collaboration on this development has been minimal. This paper marks a growing international dialogue in this field. It discusses the theoretical concepts of advanced radiographic practice and the development of advanced practitioner roles, incorporating evidence and ideas from differing international perspectives and debates progress towards a potential unified global advanced practice identity

  5. 12th Advanced Accelerator Concept (AAC 2006) Workshop

    International Nuclear Information System (INIS)

    Piot, Philippe

    2006-01-01

    Summary of the 12th Advanced Accelerator Concept (AAC 2006) Workshop help by NIU and ANL on July 10th-15th 2006 in Lake Geneva WI. The proceedings of the workshop have been published as an AIP conference proceedings '12th Advanced Accelerator Concepts Workshop' volume 877. The Twelfth Workshop on Advanced Accelerator Concepts was held at the Grand Geneva Resort in Lake Geneva, Wisconsin, from July 10 to July 15, 2006. The Workshop was sponsored by the High Energy Physics program of the U.S. Department of Energy, and was hosted by the Argonne Wakefield Accelerator Group (AWA) of Argonne National Laboratory and by Northern Illinois University. The workshop is a bi-annual meeting among physicist working on novel charged particle acceleration concept. The name 'advanced accelerator' physics covers long term research and development in beam physics and accelerator technologies. Some of the topics in advanced accelerator R and D are laser acceleration of electrons, wake field acceleration, novel high power rf source, new beam diagnostics, free-electron lasers, generating high brightness electron beams etc. The Advanced Accelerator Concept workshop is the only acknowledged and fully sponsored forum that provides a platform for inter- and cross-disciplinary discussion on various aspects of advanced accelerator and beam physics/technology concepts.

  6. Advanced Interval Management (IM) Concepts of Operations

    Science.gov (United States)

    Barmore, Bryan E.; Ahmad, Nash'at N.; Underwood, Matthew C.

    2014-01-01

    This document provides a high-level description of several advanced IM operations that NASA is considering for future research and development. It covers two versions of IM-CSPO and IM with Wake Mitigation. These are preliminary descriptions to support an initial benefits analysis

  7. Review of Advanced Accelerator Concepts R & D in Japan

    Science.gov (United States)

    Kitagawa, Yoneyoshi; Uesaka, Mitsuru; Koyama, Kazuyoshi; Nakajima, Kaszuhisa; Tajima, Toshiki; Daido, Hiroyuki; Ogata, Atsushi; Nemoto, Koshichi; Nishida, Yasushi; Yugami, Noboru; Miyamoto, Shuji; Dobashi, Katsuhiro

    2004-12-01

    More than 15 Japanese laboratories are dedicated to the advanced and compact accelerator development. Some use ultra-intense lasers and others use microwave concepts. As for the laser electron accleration, the topics are the capillary acceleration and the mono-energetic acceleration. The laser ion acceleration is also active. As well, the compatization is proceeding of the current rf accelerator. The National Institute for Radiological Science is promoting an advanced accelerator concept project mainly for the medical application.

  8. Red Teaming of Advanced Information Assurance Concepts

    International Nuclear Information System (INIS)

    DUGGAN, RUTH A.; WOOD, BRADLEY

    1999-01-01

    Red Teaming is an advanced form of assessment that can be used to identify weaknesses in a variety of cyber systems. it is especially beneficial when the target system is still in development when designers can readily affect improvements. This paper discusses the red team analysis process and the author's experiences applying this process to five selected Information Technology Office (ITO) projects. Some detail of the overall methodology, summary results from the five projects, and lessons learned are contained within this paper

  9. An Overview of Advanced Concepts for Launch

    Science.gov (United States)

    2012-02-09

    Weekly Launches” -Inspect & Rebuild. • SSTO -LOx/LH2: ms < 10% -Advanced Structure/Tank. -Aerospike. -Sensitive Design Space. Reusable... SSTO do not guarantee $ savings. 18 0 50 100 150 200 250 300 0 5000 10000 15000 20000 25000 La un ch C os t ( $ M ill io n) Payload to 185km...Higher reaction temp. •Higher specific impulse. •Less fuel. •More payload or smaller vehicle. •Fewer stages  SSTO . E/mmH = 138MJ/kg H2/mH = 3

  10. An overview of the NASA Advanced Propulsion Concepts program

    International Nuclear Information System (INIS)

    Curran, F.M.; Bennett, G.L.; Frisbee, R.H.; Sercel, J.C.; Lapointe, M.R.

    1992-07-01

    NASA Advanced Propulsion Concepts (APC) program for the development of long-term space propulsion system schemes is managed by both NASA-Lewis and the JPL and is tasked with the identification and conceptual development of high-risk/high-payoff configurations. Both theoretical and experimental investigations have been undertaken in technology areas deemed essential to the implementation of candidate concepts. These APC candidates encompass very high energy density chemical propulsion systems, advanced electric propulsion systems, and an antiproton-catalyzed nuclear propulsion concept. A development status evaluation is presented for these systems. 45 refs

  11. Advanced concepts in particle and field theory

    CERN Document Server

    Hübsch, Tristan

    2015-01-01

    Uniting the usually distinct areas of particle physics and quantum field theory, gravity and general relativity, this expansive and comprehensive textbook of fundamental and theoretical physics describes the quest to consolidate the basic building blocks of nature, by journeying through contemporary discoveries in the field, and analysing elementary particles and their interactions. Designed for advanced undergraduates and graduate students and abounding in worked examples and detailed derivations, as well as including historical anecdotes and philosophical and methodological perspectives, this textbook provides students with a unified understanding of all matter at the fundamental level. Topics range from gauge principles, particle decay and scattering cross-sections, the Higgs mechanism and mass generation, to spacetime geometries and supersymmetry. By combining historically separate areas of study and presenting them in a logically consistent manner, students will appreciate the underlying similarities and...

  12. LDRD Final Report: Advanced Hohlraum Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Ogden S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-11-08

    Indirect drive inertial confinement fusion (ICF) experiments to date have mostly used cylindrical, laser-heated, gas-filled hohlraums to produce the radiation drive needed to symmetrically implode DT-filled fusion capsules. These hohlraums have generally been unable to produce a symmetric radiation drive through the end of the desired drive pulse, and are plagued with complications due to laser-plasma interactions (LPI) that have made it difficult to predict their performance. In this project we developed several alternate hohlraum concepts. These new hohlraums utilize different hohlraum geometries, radiation shields, and foam materials in an attempt to improve performance relative to cylindrical hohlraums. Each alternate design was optimized using radiation hydrodynamic (RH) design codes to implode a reference DT capsule with a high-density carbon (HDC) ablator. The laser power and energy required to produce the desired time-dependent radiation drive, and the resulting time-dependent radiation symmetry for each new concept were compared to the results for a reference cylindrical hohlraum. Since several of the new designs needed extra laser entrance holes (LEHs), techniques to keep small LEHs open longer, including high-Z foam liners and low-Z wires at the LEH axis, were investigated numerically. Supporting experiments and target fabrication efforts were also done as part of this project. On the Janus laser facility plastic tubes open at one end (halfraums) and filled with SiO2 or Ta2O5 foam were heated with a single 2w laser. Laser propagation and backscatter were measured. Generally the measured propagation was slower than calculated, and the measured laser backscatter was less than calculated. A comparable, scaled up experiment was designed for the NIF facility and four targets were built. Since low density gold foam was identified as a desirable material for lining the LEH and the hohlraum wall, a technique was developed to

  13. A new advanced safe nuclear reactor concept

    International Nuclear Information System (INIS)

    Sefidvash, Farhang

    1999-01-01

    The reactor design is based on fluidized bed concept and utilizes pressurized water reactor technology. The fuel is automatically removed from the reactor by gravity under any accident condition. The reactor demonstrates the characteristics of inherent safety and passive cooling. Here two options for modification to the original design are proposed in order to increase the stability and thermal efficiency of the reactor. A modified version of the reactor involves the choice of supercritical steam as the coolant to produce a plant thermal efficiency of about 40%. Another is to modify the shape of the reactor core to produce a non-fluctuating bed and consequently guarantee the dynamic stability of the reactor. The mixing of Tantalum in the fuel is also proposed as an additional inhibition to power excursion. The spent fuel pellets may not be considered nuclear waste since they are in the shape and size that can easily be used as a a radioactive source for food irradiation and industrial applications. The reactor can easily operate with any desired spectrum by varying the porosity in order to be a plutonium burner or utilize a thorium fuel cycle. (author)

  14. Heuristics Applied in the Development of Advanced Space Mission Concepts

    Science.gov (United States)

    Nilsen, Erik N.

    1998-01-01

    Advanced mission studies are the first step in determining the feasibility of a given space exploration concept. A space scientist develops a science goal in the exploration of space. This may be a new observation method, a new instrument or a mission concept to explore a solar system body. In order to determine the feasibility of a deep space mission, a concept study is convened to determine the technology needs and estimated cost of performing that mission. Heuristics are one method of defining viable mission and systems architectures that can be assessed for technology readiness and cost. Developing a viable architecture depends to a large extent upon extending the existing body of knowledge, and applying it in new and novel ways. These heuristics have evolved over time to include methods for estimating technical complexity, technology development, cost modeling and mission risk in the unique context of deep space missions. This paper examines the processes involved in performing these advanced concepts studies, and analyzes the application of heuristics in the development of an advanced in-situ planetary mission. The Venus Surface Sample Return mission study provides a context for the examination of the heuristics applied in the development of the mission and systems architecture. This study is illustrative of the effort involved in the initial assessment of an advance mission concept, and the knowledge and tools that are applied.

  15. Preliminary design concepts of an advanced integral reactor

    International Nuclear Information System (INIS)

    Moon, Kap S.; Lee, Doo J.; Kim, Keung K.; Chang, Moon H.; Kim, Si H.

    1997-01-01

    An integral reactor on the basis of PWR technology is being conceptually developed at KAERI. Advanced technologies such as intrinsic and passive safety features are implemented in establishing the design concepts of the reactor to enhance the safety and performance. Research and development including laboratory-scale tests are concurrently underway for confirming the technical adoption of those concepts to the rector design. The power output of the reactor will be in the range of 100MWe to 600MWe which is relatively small compared to the existing loop type reactors. The detailed analysis to assure the design concepts is in progress. (author). 3 figs, 1 tab

  16. Advancing Your Career: Concepts of Professional Nursing. Second Edition.

    Science.gov (United States)

    Kearney, Rose

    This textbook, intended for registered nurses (RN's) returning to school, is designed to provide practicing RN's with professional concepts to advance their careers. The book contains 22 chapters organized in five sections. Each chapter includes chapter objectives, key terms, key points, chapter exercises, references, and a bibliography. Section I…

  17. Identification of improvements of advanced light water reactor concepts

    International Nuclear Information System (INIS)

    Frisch, W.; Liesch, K.; Riegel, B.

    1993-01-01

    The scope of this report is to identify the improvement of reactor developments with respect to reactor safety. This includes the collection of non-proprietary information on the description of the advanced design characteristics, especially summary design descriptions and general publications. This documentation is not intended to include a safety evaluation of the advanced concepts; however, it is structured in such a way that it can serve as a basis for a future safety evaluation. This is taken into account in the structure of the information regarding the distinction of the various concepts with respect to their 'advancement' and the classification of design characteristics according to some basic safety aspects. The overall description concentrates on those features which are relevant to safety. Other aspects, such as economy, operational features, maintenance, the construction period, etc...are not considered explicitly in this report

  18. Advanced laser sensing receiver concepts based on FPA technology

    International Nuclear Information System (INIS)

    Jacobson, Phillip L.; Petrin, Roger R.; Jolin, John L.; Foy, Bernard R.; Lowrance, J.L.; Renda, George

    2002-01-01

    The ultimate performance of any remote sensor is ideally governed by the hardware signal-to-noise capability and allowed signal-averaging time. In real-world scenarios, this may not be realizable and the limiting factors may suggest the need for more advanced capabilities. Moving from passive to active remote sensors offers the advantage of control over the illumination source, the laser. Added capabilities may include polarization discrimination, instantaneous imaging, range resolution, simultaneous multi-spectral measurement, or coherent detection. However, most advanced detection technology has been engineered heavily towards the straightforward passive sensor requirements, measuring an integrated photon flux. The need for focal plane array technology designed specifically for laser sensing has been recognized for some time, but advances have only recently made the engineering possible. This paper will present a few concepts for laser sensing receiver architectures, the driving specifications behind those concepts, and test/modeling results of such designs.

  19. Systems analysis and futuristic designs of advanced biofuel factory concepts.

    Energy Technology Data Exchange (ETDEWEB)

    Chianelli, Russ; Leathers, James; Thoma, Steven George; Celina, Mathias C.; Gupta, Vipin P.

    2007-10-01

    The U.S. is addicted to petroleum--a dependency that periodically shocks the economy, compromises national security, and adversely affects the environment. If liquid fuels remain the main energy source for U.S. transportation for the foreseeable future, the system solution is the production of new liquid fuels that can directly displace diesel and gasoline. This study focuses on advanced concepts for biofuel factory production, describing three design concepts: biopetroleum, biodiesel, and higher alcohols. A general schematic is illustrated for each concept with technical description and analysis for each factory design. Looking beyond current biofuel pursuits by industry, this study explores unconventional feedstocks (e.g., extremophiles), out-of-favor reaction processes (e.g., radiation-induced catalytic cracking), and production of new fuel sources traditionally deemed undesirable (e.g., fusel oils). These concepts lay the foundation and path for future basic science and applied engineering to displace petroleum as a transportation energy source for good.

  20. MSFC Advanced Concepts Office and the Iterative Launch Vehicle Concept Method

    Science.gov (United States)

    Creech, Dennis

    2011-01-01

    This slide presentation reviews the work of the Advanced Concepts Office (ACO) at Marshall Space Flight Center (MSFC) with particular emphasis on the method used to model launch vehicles using INTegrated ROcket Sizing (INTROS), a modeling system that assists in establishing the launch concept design, and stage sizing, and facilitates the integration of exterior analytic efforts, vehicle architecture studies, and technology and system trades and parameter sensitivities.

  1. Development of environmentally advanced hydropower turbine system design concepts

    International Nuclear Information System (INIS)

    Franke, G.F.; Webb, D.R.; Fisher, R.K. Jr.

    1997-08-01

    A team worked together on the development of environmentally advanced hydro turbine design concepts to reduce hydropower''s impact on the environment, and to improve the understanding of the technical and environmental issues involved, in particular, with fish survival as a result of their passage through hydro power sites. This approach brought together a turbine design and manufacturing company, biologists, a utility, a consulting engineering firm and a university research facility, in order to benefit from the synergy of diverse disciplines. Through a combination of advanced technology and engineering analyses, innovative design concepts adaptable to both new and existing hydro facilities were developed and are presented. The project was divided into 4 tasks. Task 1 investigated a broad range of environmental issues and how the issues differed throughout the country. Task 2 addressed fish physiology and turbine physics. Task 3 investigated individual design elements needed for the refinement of the three concept families defined in Task 1. Advanced numerical tools for flow simulation in turbines are used to quantify characteristics of flow and pressure fields within turbine water passageways. The issues associated with dissolved oxygen enhancement using turbine aeration are presented. The state of the art and recent advancements of this technology are reviewed. Key elements for applying turbine aeration to improve aquatic habitat are discussed and a review of the procedures for testing of aerating turbines is presented. In Task 4, the results of the Tasks were assembled into three families of design concepts to address the most significant issues defined in Task 1. The results of the work conclude that significant improvements in fish passage survival are achievable

  2. Development of environmentally advanced hydropower turbine system design concepts

    Energy Technology Data Exchange (ETDEWEB)

    Franke, G.F.; Webb, D.R.; Fisher, R.K. Jr. [Voith Hydro, Inc. (United States)] [and others

    1997-08-01

    A team worked together on the development of environmentally advanced hydro turbine design concepts to reduce hydropower`s impact on the environment, and to improve the understanding of the technical and environmental issues involved, in particular, with fish survival as a result of their passage through hydro power sites. This approach brought together a turbine design and manufacturing company, biologists, a utility, a consulting engineering firm and a university research facility, in order to benefit from the synergy of diverse disciplines. Through a combination of advanced technology and engineering analyses, innovative design concepts adaptable to both new and existing hydro facilities were developed and are presented. The project was divided into 4 tasks. Task 1 investigated a broad range of environmental issues and how the issues differed throughout the country. Task 2 addressed fish physiology and turbine physics. Task 3 investigated individual design elements needed for the refinement of the three concept families defined in Task 1. Advanced numerical tools for flow simulation in turbines are used to quantify characteristics of flow and pressure fields within turbine water passageways. The issues associated with dissolved oxygen enhancement using turbine aeration are presented. The state of the art and recent advancements of this technology are reviewed. Key elements for applying turbine aeration to improve aquatic habitat are discussed and a review of the procedures for testing of aerating turbines is presented. In Task 4, the results of the Tasks were assembled into three families of design concepts to address the most significant issues defined in Task 1. The results of the work conclude that significant improvements in fish passage survival are achievable.

  3. Design and analysis of advanced flight planning concepts

    Science.gov (United States)

    Sorensen, John A.

    1987-01-01

    The objectives of this continuing effort are to develop and evaluate new algorithms and advanced concepts for flight management and flight planning. This includes the minimization of fuel or direct operating costs, the integration of the airborne flight management and ground-based flight planning processes, and the enhancement of future traffic management systems design. Flight management (FMS) concepts are for on-board profile computation and steering of transport aircraft in the vertical plane between a city pair and along a given horizontal path. Flight planning (FPS) concepts are for the pre-flight ground based computation of the three-dimensional reference trajectory that connects the city pair and specifies the horizontal path, fuel load, and weather profiles for initializing the FMS. As part of these objectives, a new computer program called EFPLAN has been developed and utilized to study advanced flight planning concepts. EFPLAN represents an experimental version of an FPS. It has been developed to generate reference flight plans compatible as input to an FMS and to provide various options for flight planning research. This report describes EFPLAN and the associated research conducted in its development.

  4. Composite Structure Modeling and Analysis of Advanced Aircraft Fuselage Concepts

    Science.gov (United States)

    Mukhopadhyay, Vivek; Sorokach, Michael R.

    2015-01-01

    NASA Environmentally Responsible Aviation (ERA) project and the Boeing Company are collabrating to advance the unitized damage arresting composite airframe technology with application to the Hybrid-Wing-Body (HWB) aircraft. The testing of a HWB fuselage section with Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) construction is presently being conducted at NASA Langley. Based on lessons learned from previous HWB structural design studies, improved finite-element models (FEM) of the HWB multi-bay and bulkhead assembly are developed to evaluate the performance of the PRSEUS construction. In order to assess the comparative weight reduction benefits of the PRSEUS technology, conventional cylindrical skin-stringer-frame models of a cylindrical and a double-bubble section fuselage concepts are developed. Stress analysis with design cabin-pressure load and scenario based case studies are conducted for design improvement in each case. Alternate analysis with stitched composite hat-stringers and C-frames are also presented, in addition to the foam-core sandwich frame and pultruded rod-stringer construction. The FEM structural stress, strain and weights are computed and compared for relative weight/strength benefit assessment. The structural analysis and specific weight comparison of these stitched composite advanced aircraft fuselage concepts demonstrated that the pressurized HWB fuselage section assembly can be structurally as efficient as the conventional cylindrical fuselage section with composite stringer-frame and PRSEUS construction, and significantly better than the conventional aluminum construction and the double-bubble section concept.

  5. Preliminary design concepts for the advanced neutron source reactor systems

    International Nuclear Information System (INIS)

    Peretz, F.J.

    1988-01-01

    This paper describes the initial design work to develop the reactor systems hardware concepts for the advanced neutron source (ANS) reactor. This project has not yet entered the conceptual design phase; thus, design efforts are quite preliminary. This paper presents the collective work of members of the Oak Ridge National Laboratory, Martin Marietta Energy Systems, Inc., Engineering Division, and other participating organizations. The primary purpose of this effort is to show that the ANS reactor concept is realistic from a hardware standpoint and to show that project objectives can be met. It also serves to generate physical models for use in neutronic and thermal-hydraulic core design efforts and defines the constraints and objectives for the design. Finally, this effort will develop the criteria for use in the conceptual design of the reactor

  6. New Developments in the Simulation of Advanced Accelerator Concepts

    International Nuclear Information System (INIS)

    Paul, K.; Cary, J.R.; Cowan, B.; Bruhwiler, D.L.; Geddes, C.G.R.; Mullowney, P.J.; Messmer, P.; Esarey, E.; Cormier-Michel, E.; Leemans, W.P.; Vay, J.-L.

    2008-01-01

    Improved computational methods are essential to the diverse and rapidly developing field of advanced accelerator concepts. We present an overview of some computational algorithms for laser-plasma concepts and high-brightness photocathode electron sources. In particular, we discuss algorithms for reduced laser-plasma models that can be orders of magnitude faster than their higher-fidelity counterparts, as well as important on-going efforts to include relevant additional physics that has been previously neglected. As an example of the former, we present 2D laser wakefield accelerator simulations in an optimal Lorentz frame, demonstrating and gt;10 GeV energy gain of externally injected electrons over a 2 m interaction length, showing good agreement with predictions from scaled simulations and theory, with a speedup factor of ∼2,000 as compared to standard particle-in-cell.

  7. Integrated environmental control concepts for advanced power systems

    International Nuclear Information System (INIS)

    Rubin, E.S.; Kalagnanam, J.R.; Berkenpas, M.B.

    1996-01-01

    For both conventional and advanced power systems, the capability to estimate the performance and cost of environmental control systems is critical to a variety of planning and analysis requirements faced by utilities, regulators, researchers and analysts in the public and private sectors. This paper describes a computer model developed for the U.S. Department of Energy (USDOE) to provide an up-to-date capability for analyzing a variety of pre-combustion, combustion, and post-combustion options in an integrated framework. A unique feature of the model allows performance and costs of integrated environmental control concepts to be modeled probabilistically as a means of characterizing uncertainties and risks. Examples are presented of model applications comparing conventional and advanced emission control designs. 13 refs, 6 figs, 5 tabs

  8. Advanced remotely maintainable force-reflecting servomanipulator concept

    International Nuclear Information System (INIS)

    Kuban, D.P.; Martin, H.L.

    1984-01-01

    A remotely maintainable force-reflecting servomanipulator concept is being developed at the Oak Ridge National Laboratory as part of the Consolidated Fuel Reprocessing Program. This new manipulator addresses requirements of advanced nuclear fuel reprocessing with emphasis on force reflection, remote maintainability, reliability, radiation tolerance, and corrosion resistance. The advanced servomanipulator is uniquely subdivided into remotely replaceable modules which will permit in situ manipulator repair by spare module replacement. Manipulator modularization and increased reliability are accomplished through a force transmission system that uses gears and torque tubes. Digital control algorithms and mechanical precision are used to offset the increased backlash, friction, and inertia resulting from the gear drives. This results in the first remotely maintainable force-reflecting servomanipulator in the world. 10 references, 4 figures, 1 table

  9. Post Landsat-D advanced concept evaluation /PLACE/

    Science.gov (United States)

    Alexander, L. D.; Alvarado, U. R.; Flatow, F. S.

    1979-01-01

    The aim of the Post Landsat-D Advanced Concept Evaluation (PLACE) program was to identify the key technology requirements of earth resources satellite systems for the 1985-2000 period. The program involved four efforts: (1) examination of future needs in the earth resources area, (2) creation of a space systems technology model capable of satisfying these needs, (3) identification of key technology requirements posed by this model, and (4) development of a methodology (PRISM) to assist in the priority structuring of the resulting technologies.

  10. Experimentation and evaluation of advanced integrated system concepts

    Science.gov (United States)

    Ross, M.; Garrigus, K.; Gottschalck, J.; Rinearson, L.; Longee, E.

    1980-09-01

    This final report examines the implementation of a time-phased test bed for experimentation and evaluation of advanced system concepts relative to the future Defense Switched Network (DSN). After identifying issues pertinent to the DSN, a set of experiments which address these issues are developed. Experiments are ordered based on their immediacy and relative importance to DSN development. The set of experiments thus defined allows requirements for a time phased implementation of a test bed to be identified, and several generic test bed architectures which meet these requirements are examined. Specific architecture implementations are costed and cost/schedule profiles are generated as a function of experimental capability. The final recommended system consists of two separate test beds: a circuit switch test bed, configured around an off-the-shelf commercial switch, and directed toward the examination of nearer term and transitional issues raised by the evolving DSN; and a packet/hybrid test bed, featuring a discrete buildup of new hardware and software modules, and directed toward examination of the more advanced integrated voice and data telecommunications issues and concepts.

  11. Calculation methods for advanced concept light water reactor lattices

    International Nuclear Information System (INIS)

    Carmona, S.

    1986-01-01

    In the last few years s several advanced concepts for fuel rod lattices have been studied. Improved fuel utilization is one of the major aims in the development of new fuel rod designs and lattice modifications. By these changes s better performance in fuel economics s fuel burnup and material endurance can be achieved in the frame of the well-known basic Light Water Reactor technology. Among the new concepts involved in these studies that have attracted serious attention are lattices consisting of arrays of annular rods duplex pellet rods or tight multicells. These new designs of fuel rods and lattices present several computational problems. The treatment of resonance shielded cross sections is a crucial point in the analyses of these advanced concepts . The purpose of this study was to assess adequate approximation methods for calculating as accurately as possible, resonance shielding for these new lattices. Although detailed and exact computational methods for the evaluation of the resonance shielding in these lattices are possible, they are quite inefficient when used in lattice codes. The computer time and memory required for this kind of computations are too large to be used in an acceptable routine manner. In order to over- come these limitations and to make the analyses possible with reasonable use of computer resources s approximation methods are necessary. Usual approximation methods, for the resonance energy regions used in routine lattice computer codes, can not adequately handle the evaluation of these new fuel rod lattices. The main contribution of the present work to advanced lattice concepts is the development of an equivalence principle for the calculation of resonance shielding in the annular fuel pellet zone of duplex pellets; the duplex pellet in this treatment consists of two fuel zones with the same absorber isotope in both regions. In the transition from a single duplex rod to an infinite array of this kind of fuel rods, the similarity of the

  12. Induction of systemic CTL responses in melanoma patients by dendritic cell vaccination: Cessation of CTL responses is associated with disease progression

    DEFF Research Database (Denmark)

    Andersen, M.H.; Keikavoussi, P.; Brocker, E.B.

    2001-01-01

    Two HLA-A2-positive patients with advanced stage IV melanoma were treated with monocyte-derived dendritic cells (DC) pulsed with either tumor peptide antigens from gp100, MART-1 and MAGE- 3 alone or in combination with autologous oncolysates. Clinically, the rapid progression of disease...... by Western blotting was decreased in PBL at this time. In summary, our data confirm that DC-based vaccinations induce peptide-specific T cells in the peripheral blood of advanced-stage melanoma patients. Although successful induction of systemic tumor antigen-specific CTL may not lead to objective clinical...

  13. Advanced Gas Storage Concepts: Technologies for the Future

    Energy Technology Data Exchange (ETDEWEB)

    Freeway, Katy (PB-KBB Inc.); Rogers, R.E. (Mississippi State University); DeVries, Kerry L.; Nieland, Joel D.; Ratigan, Joe L.; Mellegard, Kirby D. (RESPEC)

    2000-02-01

    This full text product includes: 1) A final technical report titled Advanced Underground Gas Storage Concepts, Refrigerated-Mined Cavern Storage and presentations from two technology transfer workshops held in 1998 in Houston, Texas, and Pittsburgh, Pennsylvania (both on the topic of Chilled Gas Storage in Mined Caverns); 2) A final technical report titled Natural Gas Hydrates Storage Project, Final Report 1 October 1997 - 31 May 1999; 3) A final technical report titled Natural Gas Hydrates Storage Project Phase II: Conceptual Design and Economic Study, Final Report 9 June - 10 October 1999; 4) A final technical report titled Commerical Potential of Natural Gas Storage in Lined Rock Caverns (LRC) and presentations from a DOE-sponsored workshop on Alternative Gas Storage Technologies, held Feb 17, 2000 in Pittsburgh, PA; and 5) Phase I and Phase II topical reports titled Feasibility Study for Lowering the Minimum Gas Pressure in Solution-Mined Caverns Based on Geomechanical Analyses of Creep-Induced Damage and Healing.

  14. Advanced direct liquefaction concepts for PETC generic units

    Energy Technology Data Exchange (ETDEWEB)

    1992-04-01

    In the Advance Coal Liquefaction Concept Proposal (ACLCP) carbon monoxide (CO) and water have been proposed as the primary reagents in the pretreatment process. The main objective of this project is to develop a methodology for pretreating coal under mild conditions based on a combination of existing processes which have shown great promise in liquefaction, extraction and pyrolysis studies. The aim of this pretreatment process is to partially depolymerise the coal, eliminate oxygen and diminish the propensity for retograde reactions during subsequent liquefaction. The desirable outcome of the CO pretreatment step should be: (1) enhanced liquefaction activity and/or selectivity toward products of higher quality due to chemical modification of the coal structure; (2) cleaner downstream products; (3) overall improvement in operability and process economics.

  15. Human Research Program Advanced Exercise Concepts (AEC) Overview

    Science.gov (United States)

    Perusek, Gail; Lewandowski, Beth; Nall, Marsha; Norsk, Peter; Linnehan, Rick; Baumann, David

    2015-01-01

    Exercise countermeasures provide benefits that are crucial for successful human spaceflight, to mitigate the spaceflight physiological deconditioning which occurs during exposure to microgravity. The NASA Human Research Program (HRP) within the Human Exploration and Operations Mission Directorate (HEOMD) is managing next generation Advanced Exercise Concepts (AEC) requirements development and candidate technology maturation to Technology Readiness Level (TRL) 7 (ground prototyping and flight demonstration) for all exploration mission profiles from Multi Purpose Crew Vehicle (MPCV) Exploration Missions (up to 21 day duration) to Mars Transit (up to 1000 day duration) missions. These validated and optimized exercise countermeasures systems will be provided to the ISS Program and MPCV Program for subsequent flight development and operations. The International Space Station (ISS) currently has three major pieces of operational exercise countermeasures hardware: the Advanced Resistive Exercise Device (ARED), the second-generation (T2) treadmill, and the cycle ergometer with vibration isolation system (CEVIS). This suite of exercise countermeasures hardware serves as a benchmark and is a vast improvement over previous generations of countermeasures hardware, providing both aerobic and resistive exercise for the crew. However, vehicle and resource constraints for future exploration missions beyond low Earth orbit will require that the exercise countermeasures hardware mass, volume, and power be minimized, while preserving the current ISS capabilities or even enhancing these exercise capabilities directed at mission specific physiological functional performance and medical standards requirements. Further, mission-specific considerations such as preservation of sensorimotor function, autonomous and adaptable operation, integration with medical data systems, rehabilitation, and in-flight monitoring and feedback are being developed for integration with the exercise

  16. Theoretical Investigations of Plasma-Based Accelerators and Other Advanced Accelerator Concepts

    International Nuclear Information System (INIS)

    Shuets, G.

    2004-01-01

    Theoretical investigations of plasma-based accelerators and other advanced accelerator concepts. The focus of the work was on the development of plasma based and structure based accelerating concepts, including laser-plasma, plasma channel, and microwave driven plasma accelerators

  17. Advanced storage concepts for solar and low energy buildings, IEA-SHC Task 32. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, J.M.; Andersen, Elsa; Furbo, S.

    2008-01-15

    This report reports on the results of the activities carried through in connection with the Danish part of the IEA SHC Task 32 project: Advanced Storage Concepts for Solar and Low Energy Buildings. The Danish involvement has focused on Subtask C: Storage Concepts Based on Phase Change Materials and Subtask D: Storage Concepts Based on Advanced Water Tanks and Special Devices. The report describes activities concerning heat-of-fusion storage and advanced water storage. (BA)

  18. Figuring the Context of CTL under 2013 Curiculum

    Directory of Open Access Journals (Sweden)

    Chairina Nasir

    2017-06-01

    Full Text Available The 2013 curriculum states that the purpose of teaching English for junior high school is to develop students’ communicative competence. In line with this expectation, several learning characteristics have been defined i.e. learning from model, observing, questioning, gathering information, associating, and communicating. Therefore, the teaching approaches that are used by the teacher in teaching English must suit the criteria to promote students' communicative competence. Contextual Teaching and learning (CTL seems to be compatible as an approach since it has the the characteristics of constructivism, questioning, inquiry, learning community, modelling, reflection, and authentic assessment, which are similar to the learning characteristics mentioned above, which are similar to the learning characteristics mentioned above. , which are similar to the learning characteristics mentioned above. Therefore, a qualitative research concerning the issue was conducted to see how CTL approach is implemented under the 2013 curriculum in teaching reading comprehension. From the result of observation, questionnaire, and interview as the instruments, it was found that CTL was implemented properly from phase to phase and is applicable to be implemented under the curriculum. Also, it promotes active and enjoyable learning, facilitates the students to comprehend the material and helps them to implement the knowledge in real life. The. The teacher had implemented all of the procedures of CTL under the instruction of the 2013 curriculum. Thus, applying the CTL CTL approach in the process of teaching for the 2013 curriculum for the 2013 curriculum is recommended since it gives satisfactory benefits for students.

  19. Conceptual design study advanced concepts test (ACT) facility

    Energy Technology Data Exchange (ETDEWEB)

    Zaloudek, F.R.

    1978-09-01

    The Advanced Concepts Test (ACT) Project is part of program for developing improved power plant dry cooling systems in which ammonia is used as a heat transfer fluid between the power plant and the heat rejection tower. The test facility will be designed to condense 60,000 lb/hr of exhaust steam from the No. 1 turbine in the Kern Power Plant at Bakersfield, CA, transport the heat of condensation from the condenser to the cooling tower by an ammonia phase-change heat transport system, and dissipate this heat to the environs by a dry/wet deluge tower. The design and construction of the test facility will be the responsibility of the Electric Power Research Institute. The DOE, UCC/Linde, and the Pacific Northwest Laboratories will be involved in other phases of the project. The planned test facilities, its structures, mechanical and electrical equipment, control systems, codes and standards, decommissioning requirements, safety and environmental aspects, and energy impact are described. Six appendices of related information are included. (LCL)

  20. NASA Advanced Explorations Systems: Concepts for Logistics to Living

    Science.gov (United States)

    Shull, Sarah A.; Howe, A. Scott; Flynn, Michael T.; Howard, Robert

    2012-01-01

    , Howard 2010]. Several of the L2L concepts that have shown the most potential in the past are based on NASA cargo transfer bags (CTBs) or their equivalents which are currently used to transfer cargo to and from the ISS. A high percentage of all logistics supplies are packaging mass and for a 6-month mission a crew of four might need over 100 CTBs. These CTBs are used for on-orbit transfer and storage but eventually becomes waste after use since down mass is very limited. The work being done in L2L also considering innovative interior habitat construction that integrate the CTBs into the walls of future habitats. The direct integration could provide multiple functions: launch packaging, stowage, radiation protection, water processing, life support augmentation, as well as structure. Reuse of these CTBs would reduce the amount of waste generated and also significantly reduce future up mass requirements for exploration missions. Also discussed here is the L2L water wall , an innovative reuse of an unfolded CTB as a passive water treatment system utilizing forward osmosis. The bags have been modified to have an inner membrane liner that allows them to purify wastewater. They may also provide a structural water-wall element that can be used to provide radiation protection and as a structural divider. Integration of the components into vehicle/habitat architecture and consideration of operations concepts and human factors will be discussed. In the future these bags could be designed to treat wastewater, concentrated brines, and solid wastes, and to dewater solid wastes and produce a bio-stabilized construction element. This paper will describe the follow-on work done in design, fabrication and demonstrations of various L2L concepts, including advanced CTBs for reuse/repurposing, internal outfitting studies and the CTB-based forward osmosis water wall.

  1. Advanced Accelerator Development Strategy Report: DOE Advanced Accelerator Concepts Research Roadmap Workshop

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-02-03

    Over a full two day period, February 2–3, 2016, the Office of High Energy Physics convened a workshop in Gaithersburg, MD to seek community input on development of an Advanced Accelerator Concepts (AAC) research roadmap. The workshop was in response to a recommendation by the HEPAP Accelerator R&D Subpanel [1] [2] to “convene the university and laboratory proponents of advanced acceleration concepts to develop R&D roadmaps with a series of milestones and common down selection criteria towards the goal for constructing a multi-TeV e+e– collider” (the charge to the workshop can be found in Appendix A). During the workshop, proponents of laser-driven plasma wakefield acceleration (LWFA), particle-beam-driven plasma wakefield acceleration (PWFA), and dielectric wakefield acceleration (DWFA), along with a limited number of invited university and laboratory experts, presented and critically discussed individual concept roadmaps. The roadmap workshop was preceded by several preparatory workshops. The first day of the workshop featured presentation of three initial individual roadmaps with ample time for discussion. The individual roadmaps covered a time period extending until roughly 2040, with the end date assumed to be roughly appropriate for initial operation of a multi-TeV e+e– collider. The second day of the workshop comprised talks on synergies between the roadmaps and with global efforts, potential early applications, diagnostics needs, simulation needs, and beam issues and challenges related to a collider. During the last half of the day the roadmaps were revisited but with emphasis on the next five to ten years (as specifically requested in the charge) and on common challenges. The workshop concluded with critical and unanimous endorsement of the individual roadmaps and an extended discussion on the characteristics of the common challenges. (For the agenda and list of participants see Appendix B.)

  2. Advanced Concept Exploration for Fast Ignition Science Program, Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, Richard Burnite [General Atomics; McLean, Harry M. [Lawrence Livermore National Laboratory; Theobald, Wolfgang [Laboratory for Laser Energetics; Akli, Kramer U. [The Ohio State University; Beg, Farhat N. [University of California, San Diego; Sentoku, Yasuhiko [University of Nevada, Reno; Schumacher, Douglass W. [The Ohio State University; Wei, Mingsheng [General Atomics

    2013-09-04

    The Fast Ignition (FI) Concept for Inertial Confinement Fusion (ICF) has the potential to provide a significant advance in the technical attractiveness of Inertial Fusion Energy reactors. FI differs from conventional “central hot spot” (CHS) target ignition by decoupling compression from heating: using a laser (or heavy ion beam or Z pinch) drive pulse (10’s of nanoseconds) to create a dense fuel and a second, much shorter (~10 picoseconds) high intensity pulse to ignite a small volume within the dense fuel. The physics of fast ignition process was the focus of our Advanced Concept Exploration (ACE) program. Ignition depends critically on two major issues involving Relativistic High Energy Density (RHED) physics: The laser-induced creation of fast electrons and their propagation in high-density plasmas. Our program has developed new experimental platforms, diagnostic packages, computer modeling analyses, and taken advantage of the increasing energy available at laser facilities to advance understanding of the fundamental physics underlying these issues. Our program had three thrust areas: • Understand the production and characteristics of fast electrons resulting from FI relevant laser-plasma interactions and their dependence on laser prepulse and laser pulse length. • Investigate the subsequent fast electron transport in solid and through hot (FI-relevant) plasmas. • Conduct and understand integrated core-heating experiments by comparison to simulations. Over the whole period of this project (three years for this contract), we have greatly advanced our fundamental understanding of the underlying properties in all three areas: • Comprehensive studies on fast electron source characteristics have shown that they are controlled by the laser intensity distribution and the topology and plasma density gradient. Laser pre-pulse induced pre-plasma in front of a solid surface results in increased stand-off distances from the electron origin to the high density

  3. NASA's Advanced Information Systems Technology (AIST) Program: Advanced Concepts and Disruptive Technologies

    Science.gov (United States)

    Little, M. M.; Moe, K.; Komar, G.

    2014-12-01

    NASA's Earth Science Technology Office (ESTO) manages a wide range of information technology projects under the Advanced Information Systems Technology (AIST) Program. The AIST Program aims to support all phases of NASA's Earth Science program with the goal of enabling new observations and information products, increasing the accessibility and use of Earth observations, and reducing the risk and cost of satellite and ground based information systems. Recent initiatives feature computational technologies to improve information extracted from data streams or model outputs and researchers' tools for Big Data analytics. Data-centric technologies enable research communities to facilitate collaboration and increase the speed with which results are produced and published. In the future NASA anticipates more small satellites (e.g., CubeSats), mobile drones and ground-based in-situ sensors will advance the state-of-the-art regarding how scientific observations are performed, given the flexibility, cost and deployment advantages of new operations technologies. This paper reviews the success of the program and the lessons learned. Infusion of these technologies is challenging and the paper discusses the obstacles and strategies to adoption by the earth science research and application efforts. It also describes alternative perspectives for the future program direction and for realizing the value in the steps to transform observations from sensors to data, to information, and to knowledge, namely: sensor measurement concepts development; data acquisition and management; data product generation; and data exploitation for science and applications.

  4. Advances in architectural concepts to support distributed systems design

    NARCIS (Netherlands)

    Ferreira Pires, Luis; Vissers, C.A.; van Sinderen, Marten J.

    1993-01-01

    This paper presents and discusses some architectural concepts for distributed systems design. These concepts are derived from an analysis of limitations of some currently available standard design languages. We conclude that language design should be based upon the careful consideration of

  5. Concepts and recent advances in generalized information measures and statistics

    CERN Document Server

    Kowalski, Andres M

    2013-01-01

    Since the introduction of the information measure widely known as Shannon entropy, quantifiers based on information theory and concepts such as entropic forms and statistical complexities have proven to be useful in diverse scientific research fields. This book contains introductory tutorials suitable for the general reader, together with chapters dedicated to the basic concepts of the most frequently employed information measures or quantifiers and their recent applications to different areas, including physics, biology, medicine, economics, communication and social sciences. As these quantif

  6. Advanced composites structural concepts and materials technologies for primary aircraft structures: Design/manufacturing concept assessment

    Science.gov (United States)

    Chu, Robert L.; Bayha, Tom D.; Davis, HU; Ingram, J. ED; Shukla, Jay G.

    1992-01-01

    Composite Wing and Fuselage Structural Design/Manufacturing Concepts have been developed and evaluated. Trade studies were performed to determine how well the concepts satisfy the program goals of 25 percent cost savings, 40 percent weight savings with aircraft resizing, and 50 percent part count reduction as compared to the aluminum Lockheed L-1011 baseline. The concepts developed using emerging technologies such as large scale resin transfer molding (RTM), automatic tow placed (ATP), braiding, out-of-autoclave and automated manufacturing processes for both thermoset and thermoplastic materials were evaluated for possible application in the design concepts. Trade studies were used to determine which concepts carry into the detailed design development subtask.

  7. Reference Operational Concepts for Advanced Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Hugo, Jacques Victor [Idaho National Lab. (INL), Idaho Falls, ID (United States); Farris, Ronald Keith [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    This report represents the culmination of a four-year research project that was part of the Instrumentation and Control and Human Machine Interface subprogram of the DOE Advanced Reactor Technologies program.

  8. Knowledge gaps in economic analyses of advanced reactor concepts

    International Nuclear Information System (INIS)

    Moore, M.; Pencer, J.; Leung, L.K.H.; Sadhankar, R.

    2014-01-01

    The development of next generation nuclear systems is predicated on improvement in sustainability, safety, proliferation resistance and economics. The economic assessment of the reactor concept is required as early as in the concept development stage. The Generation IV International Forum (GIF) has developed a methodology for economic assessment of the Generation IV (GEN-IV) nuclear energy systems. The GIF economics methodology was used for the assessment of one of the reactor concepts for the Super-Critical Water-cooled Reactors (SCWR), namely the European pressure-vessel type concept referred to as the High Performance Light Water Reactor (HPLWR). The economic analysis involved studying the sensitivity of two main economic indicators, namely, the Levelized Unit Electricity Cost (LUEC) and the Total Capital Investment Cost (TCIC). The knowledge gaps in estimating the capital costs and fuel costs, as well as the uncertainties in other cost parameters affecting the economic assessment of the nuclear energy system in the concept development stage are presented. (author)

  9. Advanced concepts in multi-dimensional radiation detection and imaging

    International Nuclear Information System (INIS)

    Vetter, Kai; Barnowski, Ross; Pavlovsky, Ryan; Haefner, Andy; Torii, Tatsuo; Shikaze, Yoshiaki; Sanada, Yukihisa

    2016-01-01

    Recent developments in the detector fabrication, signal readout, and data processing enable new concepts in radiation detection that are relevant for applications ranging from fundamental physics to medicine as well as nuclear security and safety. We present recent progress in multi-dimensional radiation detection and imaging in the Berkeley Applied Nuclear Physics program. It is based on the ability to reconstruct scenes in three dimensions and fuse it with gamma-ray image information. We are using the High-Efficiency Multimode Imager HEMI in its Compton imaging mode and combining it with contextual sensors such as the Microsoft Kinect or visual cameras. This new concept of volumetric imaging or scene data fusion provides unprecedented capabilities in radiation detection and imaging relevant for the detection and mapping of radiological and nuclear materials. This concept brings us one step closer to the seeing the world with gamma-ray eyes. (author)

  10. Advanced Numerical-Algebraic Thinking: Constructing the Concept of Covariation as a Prelude to the Concept of Function

    Science.gov (United States)

    Hitt, Fernando; Morasse, Christian

    2009-01-01

    Introduction: In this document we stress the importance of developing in children a structure for advanced numerical-algebraic thinking that can provide an element of control when solving mathematical situations. We analyze pupils' conceptions that induce errors in algebra due to a lack of control in connection with their numerical thinking. We…

  11. Technological advances in perioperative monitoring: Current concepts and clinical perspectives.

    Science.gov (United States)

    Chilkoti, Geetanjali; Wadhwa, Rachna; Saxena, Ashok Kumar

    2015-01-01

    Minimal mandatory monitoring in the perioperative period recommended by Association of Anesthetists of Great Britain and Ireland and American Society of Anesthesiologists are universally acknowledged and has become an integral part of the anesthesia practice. The technologies in perioperative monitoring have advanced, and the availability and clinical applications have multiplied exponentially. Newer monitoring techniques include depth of anesthesia monitoring, goal-directed fluid therapy, transesophageal echocardiography, advanced neurological monitoring, improved alarm system and technological advancement in objective pain assessment. Various factors that need to be considered with the use of improved monitoring techniques are their validation data, patient outcome, safety profile, cost-effectiveness, awareness of the possible adverse events, knowledge of technical principle and ability of the convenient routine handling. In this review, we will discuss the new monitoring techniques in anesthesia, their advantages, deficiencies, limitations, their comparison to the conventional methods and their effect on patient outcome, if any.

  12. Advanced Level Physics Students' Conceptions of Quantum Physics.

    Science.gov (United States)

    Mashhadi, Azam

    This study addresses questions about particle physics that focus on the nature of electrons. Speculations as to whether they are more like particles or waves or like neither illustrate the difficulties with which students are confronted when trying to incorporate the concepts of quantum physics into their overall conceptual framework. Such…

  13. Advanced programming concepts in a course on grammars and parsing

    NARCIS (Netherlands)

    Jeuring, J.T.; Swierstra, S.D.

    1999-01-01

    One of the important goals of the Computer Science curriculum at Utrecht University is to familiarize students with abstract programming concepts such as, for example, partial evaluation and deforestation. A course on grammars and parsing offers excellent possibilities for exemplifying and

  14. Report on the Lake Arrowhead workshop on advanced acceleration concepts

    International Nuclear Information System (INIS)

    Pellegrini, C.

    1989-03-01

    We review the present status of the field of New Acceleration Concepts, as presented at the Lake Arrowhead workshop, held at the beginning of 1989. Many new and promising results have been obtained recently, and the field is actively developing. We discuss briefly some of the main results presented at the workshop. 43 refs., 2 tabs

  15. Concept selection for advanced low-emission coal fired boiler

    Energy Technology Data Exchange (ETDEWEB)

    Gorrell, R.L. [Babcock and Wilcox Co., Barberton, OH (United States); Rodgers, L.W.; Farthing, G.A. [Babcock and Wilcox Co., Alliance, OH (United States)

    1993-12-31

    The Babcock & Wilcox Company (B&W), under contract to the US Department of Energy (DOE) with subcontract to Physical Sciences, Inc. (PSIT), the Massachusetts Institute of Technology (MIT) and United Engineers and Constructors (UE&C) has begun development of an advanced low-emission boiler system (LEBS). The initial phase of this multi-phase program required a thorough review and assessment of potential advanced technologies and techniques for control of combustion and flue gas emissions. Results of this assessment are presented in this paper.

  16. CARA, new concept of advanced fuel element for HWR

    International Nuclear Information System (INIS)

    Florido, P.C.; Crimello, R.O.; Bergallo, J.E.; Marino, A.C.; Delmastro, D.F.; Brasnarof, D.O.; Gonzalez, J.H.

    1999-01-01

    All Argentinean NPPs (2 in operation, 1 under construction), use heavy water as coolant and moderator. With very different reactor concepts (pressure Vessel and CANDU type designs), the fuel elements are completely different in its concepts too. Argentina produces both types of fuel elements at a manufacturing fuel element company, called CONUAR. The very different fuel element's designs produce a very complex economical behavior in this company, due to the low production scale. The competitiveness of the Argentinean electric system (Argentina has a market driven electric system) put another push towards to increase the economical competitiveness of the nuclear fuel cycle. At present, Argentina has a very active Slightly Enriched Uranium (SEU) Program for the pressure vessel HWR type, but without strong changes in the fuel concept itself. Then, the Atomic Energy Commission in Argentina (CNEA) has developed a new concept of fuel element, named CARA, trying to achieve very ambitious goals, and substantially improved the competitiveness of the nuclear option. The ambitious targets for CARA fuel element are compatibility (a single fuel element for all Argentinean's HWR) using a single diameter fuel rod, improve the security margins, increase the burnup and do not exceed the CANDU fabrication costs. In this paper, the CARA concept will be presented, in order to explained how to achieve all together these goals. The design attracted the interest of the nuclear power operator utility (NASA), and the fuel manufacturing company (CONUAR). Then a new Project is right now under planning with the cooperation of three parts (CNEA - NASA - CONUAR) in order to complete the whole development program in the shortest time, finishing in the commercial production of CARA fuel bundle. At the end of the this paper, future CARA development program will be described. (author)

  17. An Overview of Advanced Concepts for Near-Space Systems

    Science.gov (United States)

    2009-06-30

    2005). 39 T. R. Knowles, Levitation of a small carbon by visible light, 12th Annual Advanced Space Propulsion Workshop (2001). 40 http...372, 1948. 45 Woodward, J. and Mahood, T., “Gravity, Inertia, and Quantum Vacuum Zero Point Energy Fields,” Foundations of Physics, Vol. 31, No. 5, pp

  18. Study of advanced fuel system concepts for commercial aircraft

    Science.gov (United States)

    Coffinberry, G. A.

    1985-01-01

    An analytical study was performed in order to assess relative performance and economic factors involved with alternative advanced fuel systems for future commercial aircraft operating with broadened property fuels. The DC-10-30 wide-body tri-jet aircraft and the CF6-8OX engine were used as a baseline design for the study. Three advanced systems were considered and were specifically aimed at addressing freezing point, thermal stability and lubricity fuel properties. Actual DC-10-30 routes and flight profiles were simulated by computer modeling and resulted in prediction of aircraft and engine fuel system temperatures during a nominal flight and during statistical one-day-per-year cold and hot flights. Emergency conditions were also evaluated. Fuel consumption and weight and power extraction results were obtained. An economic analysis was performed for new aircraft and systems. Advanced system means for fuel tank heating included fuel recirculation loops using engine lube heat and generator heat. Environmental control system bleed air heat was used for tank heating in a water recirculation loop. The results showed that fundamentally all of the three advanced systems are feasible but vary in their degree of compatibility with broadened-property fuel.

  19. Advanced High and Low Fidelity HPC Simulations of FCS Concept Designs for Dynamic Systems

    National Research Council Canada - National Science Library

    Sandhu, S. S; Kanapady, R; Tamma, K. K

    2004-01-01

    ...) resources of many Army initiatives. In this paper we present a new and advanced HPC based rigid and flexible modeling and simulation technology capable of adaptive high/low fidelity modeling that is useful in the initial design concept...

  20. Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

    OpenAIRE

    Xihui "Paul" Zhang; John D. Crabtree

    2015-01-01

    Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We present a classic brain teaser that is used to communicate and demonstrate advanced software development concepts and techniques. Our results show th...

  1. Recent Advances in Airframe-Propulsion Concepts with Distributed Propulsion

    OpenAIRE

    Isikveren , A.T.; Seitz , A.; Bijewitz , J.; Hornung , M.; Mirzoyan , A.; Isyanov , A.; Godard , J.L.; Stückl , S.; Van Toor , J.

    2014-01-01

    International audience; This paper discusses design and integration associated with distributed propulsion as a means of providing motive power for future aircraft concepts. The technical work reflects activities performed within a European Commission funded Framework 7 project entitled Distributed Propulsion and Ultra-high By-Pass Rotor Study at Aircraft Level, or, DisPURSAL. In this instance, the approach of distributed propulsion includes one unique solution that integrates the fuselage wi...

  2. An advanced concept that promises ecological and economic viability

    Science.gov (United States)

    Wright, B. R.; Sedgwick, T. A.; Urie, D. M.

    1976-01-01

    The actuality of supersonic commercial service being provided by Concorde is demonstrating to the world the advantages offered by supersonic travel for both business and recreation. Public acceptance will gradually and persistently stimulate interest to proceed with a second generation design that meets updated economic and ecological standards. It is estimated that this concept could operate profitably on world-wide routes with a revenue structure based upon economy fares. Airplanes will meet all present day ecological requirements regarding noise and emissions.

  3. Quality of experience advanced concepts, applications and methods

    CERN Document Server

    Raake, Alexander

    2014-01-01

    This pioneering book develops definitions and concepts related to Quality of Experience in the context of multimedia- and telecommunications-related applications, systems and services, and applies these to various fields of communication and media technologies. The editors bring together numerous key-protagonists of the new discipline “Quality of Experience” and combine the state-of-the-art knowledge in one single volume. 

  4. Innovative concepts for marginal fields (advanced monotower developments)

    International Nuclear Information System (INIS)

    Smith, M.T.; Marks, V.E.

    1995-01-01

    The braced monotower provides a safe, functional and cost effective solution for topsides up to 500 tonnes, with up to 8 wells and standing in water depths of up to 70 meters. It is both simple in concept and structurally efficient. The superstructure is supported by a single column which is stayed by three symmetrically orientated legs. A broad mudline base is also provided to limit pile loads. The final concept offers complete protection to the risers and conductors from ship impact, as all appurtenances are housed within the central column. The basic design philosophy of the low intervention platform is to minimize the onboard equipment to that vitally needed to produce hydrocarbon. The concept eliminates the life support functions that on a normal North Sea platform can contribute up to 50% of the topside dry weight. A system of Zero Based Engineering is used that ensures each item of equipment contributes more to the NPV of the platform than the fully built-up through life cost. This effectively eliminates the operator preference factor and the ''culture'' cost

  5. A novel superconducting toroidal field magnetic concept using advanced materials

    International Nuclear Information System (INIS)

    Schwartz, J.

    1991-01-01

    The plasma physics database indicates that two distinct approaches to tokamak design may lead to commercial fusion reactors: Low Aspect ratio, high plasma current, relatively low magnetic field devices, and high Aspect ratio, high field devices. The former requires significant enhancements in plasma performance, while the latter depends primarily upon technology development. The key technology for the commercialization of the high-field approach is large, high magnetic field superconducting magnets. In this paper, the physics motivation for the high field approach and key superconducting magnet (SCM) development issues are reviewed. Improved SCM performance may be obtained from improved materials and/or improved engineering. Superconducting materials ranging from NbTi to high-T c oxides are reviewed, demonstrating the broad range of potential superconducting materials. Structural material options are discussed, including cryogenic steel alloys and fiber-reinforced composite materials. The potential for improved magnet engineering is quantified in terms of the Virial Theorem Limit, and two examples of approaches to highly optimized magnet configurations are discussed. The force-reduced concept, which is a finite application of the force-free solutions to Ampere's Law, appear promising for large SCMs but may be limited by the electromagnetics of a fusion plasma. The Solid Superconducting Cylinder (SSC) concept is proposed. This concept combines the unique properties of high-T c superconductors within a low-T c SCM to obtain (1) significant reductions in the structural material volume, (2) a decoupling of the tri-axial (compressive and tensile) stress rate, and (3) a demountable TF magnet system. The advantages of this approach are quantified in terms of a 24 T commercial reactor TF magnet system. Significant reductions in the mechanical stress and the TF radial build are demonstrated. 54 refs., 14 figs., 5 tabs

  6. An iLab for Teaching Advanced Logic Concepts with Hardware Descriptive Languages

    Science.gov (United States)

    Ayodele, Kayode P.; Inyang, Isaac A.; Kehinde, Lawrence O.

    2015-01-01

    One of the more interesting approaches to teaching advanced logic concepts is the use of online laboratory frameworks to provide student access to remote field-programmable devices. There is as yet, however, no conclusive evidence of the effectiveness of such an approach. This paper presents the Advanced Digital Lab, a remote laboratory based on…

  7. Direct Coal -to-Liquids (CTL) for Jet Fuel Using Biomass-Derived Solvents

    Energy Technology Data Exchange (ETDEWEB)

    Chauhan, Satya P. [Battelle Memorial Inst., Columbus, OH (United States); Garbark, Daniel B. [Battelle Memorial Inst., Columbus, OH (United States); Taha, Rachid [Battelle Memorial Inst., Columbus, OH (United States); Peterson, Rick [Battelle Memorial Inst., Columbus, OH (United States)

    2017-09-30

    Battelle has demonstrated a novel and potentially breakthrough technology for a direct coal-to-liquids (CTL) process for producing jet fuel using biomass-derived coal solvents (bio-solvents). The Battelle process offers a significant reduction in capital and operating costs and a substantial reduction in greenhouse gas (GHG) emissions, without requiring carbon capture and storage (CCS). The results of the project are the advancement of three steps of the hybrid coal/biomass-to-jet fuel process to the technology readiness level (TRL) of 5. The project objectives were achieved over two phases. In Phase 1, all three major process steps were explored and refined at bench-scale, including: (1) biomass conversion to high hydrogen-donor bio-solvent; (2) coal dissolution in biomass-derived bio-solvent, without requiring molecular H2, to produce a synthetic crude (syncrude); and (3) two-stage catalytic hydrotreating/hydrogenation of syncrude to jet fuel and other distillates. In Phase 2, all three subsystems of the CTL process were scaled up to a pre-pilot scale, and an economic analysis was carried out. A total of over 40 bio-solvents were identified and prepared. The most unique attribute of Battelle’s bio-solvents is their ability to provide much-needed hydrogen to liquefy coal and thus increase its hydrogen content so much that the resulting syncrude is liquid at room temperature. Based on the laboratory-scale testing with bituminous coals from Ohio and West Virginia, a total of 12 novel bio-solvent met the goal of greater than 80% coal solubility, with 8 bio-solvents being as good as or better than a well-known but expensive hydrogen-donor solvent, tetralin. The Battelle CTL process was then scaled up to 1 ton/day (1TPD) at a pre-pilot facility operated in Morgantown, WV. These tests were conducted, in part, to produce enough material for syncrude-upgrading testing. To convert the Battelle-CTL syncrude into a form suitable as a blending stock for jet

  8. Advanced sulfur control concepts for hot gas desulfurization technology

    International Nuclear Information System (INIS)

    1998-01-01

    The objective of this project is to develop a hot-gas desulfurization process scheme for control of H 2 S in HTHP coal gas that can be more simply and economically integrated with known regenerable sorbents in DOE/METC-sponsored work than current leading hot-gas desulfurization technologies. In addition to being more economical, the process scheme to be developed must yield an elemental sulfur byproduct. The Direct Sulfur Recovery Process (DSRP), a leading process for producing an elemental sulfur byproduct in hot-gas desulfurization systems, incurs a coal gas use penalty, because coal gas is required to reduce the SO 2 in regeneration off-gas to elemental sulfur. Alternative regeneration schemes, which avoid coal gas use and produce elemental sulfur, will be evaluated. These include (i) regeneration of sulfided sorbent using SO 2 ; (ii) partial oxidation of sulfided sorbent in an O 2 starved environment; and (iii) regeneration of sulfided sorbent using steam to produce H 2 S followed by direct oxidation of H 2 S to elemental sulfur. Known regenerable sorbents will be modified to improve the feasibility of the above alternative regeneration approaches. Performance characteristics of the modified sorbents and processes will be obtained through lab- and bench-scale testing. Technical and economic evaluation of the most promising processes concept(s) will be carried out

  9. Advanced IGCC-Hypogen concepts for a developing hydrogen market

    Energy Technology Data Exchange (ETDEWEB)

    Starr, F.; Cormos, C.-C.; Tzimas, E.; Brown, A. [European Commission, Petten (Netherlands). DG Joint Research Centre, Institute for Energy

    2007-07-01

    With FP6 the EU is funding a project called 'Dynamis' which aims to design plants to generate electricity, plus a limited amount of hydrogen from fossil fuels, in which the CO{sub 2} is captured and stored underground. Such plants have been characterised as being of the 'HYPOGEN' type since they generate both hydrogen and electric power. As the hydrogen market develops IGCC-Hypogen based systems will need to produce much greater amounts of hydrogen. It is also desirable that such plants should be able to vary the proportion of hydrogen-to-electricity. This will enable IGCC-Hypogen plants to load follow and two-shift as electricity demand from the grid changes. Such variations in power output are not always practical with existing designs of electricity-only IGCCs. This paper reviews the technical issues involved in providing a high-flexibility IGCC-Hypogen plant. Three such concepts are discussed (1) very limited flexibility in which the changes from a fixed hydrogen-electricity ratio concept are minor, (2) moderate level of flexibility in which the limit is imposed by the CCGT gas turbine turndown (3) complete flexibility, the plant being able produce the energy as all-electricity or all-hydrogen. 9 refs., 2 figs., 1 tab.

  10. Advanced concept for a crewed mission to the martian moons

    Science.gov (United States)

    Conte, Davide; Di Carlo, Marilena; Budzyń, Dorota; Burgoyne, Hayden; Fries, Dan; Grulich, Maria; Heizmann, Sören; Jethani, Henna; Lapôtre, Mathieu; Roos, Tobias; Castillo, Encarnación Serrano; Schermann, Marcel; Vieceli, Rhiannon; Wilson, Lee; Wynard, Christopher

    2017-10-01

    This paper presents the conceptual design of the IMaGInE (Innovative Mars Global International Exploration) Mission. The mission's objectives are to deliver a crew of four astronauts to the surface of Deimos and perform a robotic exploration mission to Phobos. Over the course of the 343 day mission during the years 2031 and 2032, the crew will perform surface excursions, technology demonstrations, In Situ Resource Utilization (ISRU) of the Martian moons, as well as site reconnaissance for future human exploration of Mars. This mission design makes use of an innovative hybrid propulsion concept (chemical and electric) to deliver a relatively low-mass reusable crewed spacecraft (approximately 100 mt) to cis-martian space. The crew makes use of torpor which minimizes launch payload mass. Green technologies are proposed as a stepping stone towards minimum environmental impact space access. The usage of beamed energy to power a grid of decentralized science stations is introduced, allowing for large scale characterization of the Martian environment. The low-thrust outbound and inbound trajectories are computed through the use of a direct method and a multiple shooting algorithm that considers various thrust and coast sequences to arrive at the final body with zero relative velocity. It is shown that the entire mission is rooted within the current NASA technology roadmap, ongoing scientific investments and feasible with an extrapolated NASA Budget. The presented mission won the 2016 Revolutionary Aerospace Systems Concepts - Academic Linkage (RASC-AL) competition.

  11. Knowledge based systems advanced concepts, techniques and applications

    CERN Document Server

    1997-01-01

    The field of knowledge-based systems (KBS) has expanded enormously during the last years, and many important techniques and tools are currently available. Applications of KBS range from medicine to engineering and aerospace.This book provides a selected set of state-of-the-art contributions that present advanced techniques, tools and applications. These contributions have been prepared by a group of eminent researchers and professionals in the field.The theoretical topics covered include: knowledge acquisition, machine learning, genetic algorithms, knowledge management and processing under unc

  12. Advances in sliding mode control concept, theory and implementation

    CERN Document Server

    Janardhanan, S; Spurgeon, Sarah

    2013-01-01

    The sliding mode control paradigm has become a mature technique for the design of robust controllers for a wide class of systems including nonlinear, uncertain and time-delayed systems. This book is a collection of plenary and invited talks delivered at the 12th IEEE International Workshop on Variable Structure System held at the Indian Institute of Technology, Mumbai, India in January 2012. After the workshop, these researchers were invited to develop book chapters for this edited collection in order to reflect the latest results and open research questions in the area. The contributed chapters have been organized by the editors to reflect the various themes of sliding mode control which are the current areas of theoretical research and applications focus; namely articulation of the fundamental underpinning theory of the sliding mode design paradigm, sliding modes for decentralized system representations, control of time-delay systems, the higher order sliding mode concept, results applicable to nonlinear an...

  13. Small angle slot divertor concept for long pulse advanced tokamaks

    Science.gov (United States)

    Guo, H. Y.; Sang, C. F.; Stangeby, P. C.; Lao, L. L.; Taylor, T. S.; Thomas, D. M.

    2017-04-01

    SOLPS-EIRENE edge code analysis shows that a gas-tight slot divertor geometry with a small-angle (glancing-incidence) target, named the small angle slot (SAS) divertor, can achieve cold, dissipative/detached divertor conditions at relatively low values of plasma density at the outside midplane separatrix. SAS exhibits the following key features: (1) strong enhancement of the buildup of neutral density in a localized region near the plasma strike point on the divertor target; (2) spreading of the cooling front across the divertor target with the slot gradually flaring out from the strike point, thus effectively reducing both heat flux and erosion on the entire divertor target surface. Such a divertor may potentially provide a power and particle handling solution for long pulse advanced tokamaks.

  14. ADVANCED SULFUR CONTROL CONCEPTS FOR HOT-GAS DESULFURIZATION TECHNOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    A. LOPEZ ORTIZ; D.P. HARRISON; F.R. GROVES; J.D. WHITE; S. ZHANG; W.-N. HUANG; Y. ZENG

    1998-10-31

    This research project examined the feasibility of a second generation high-temperature coal gas desulfurization process in which elemental sulfur is produced directly during the sorbent regeneration phase. Two concepts were evaluated experimentally. In the first, FeS was regenerated in a H2O-O2 mixture. Large fractions of the sulfur were liberated in elemental form when the H2O-O2 ratio was large. However, the mole percent of elemental sulfur in the product was always quite small (<<1%) and a process based on this concept was judged to be impractical because of the low temperature and high energy requirements associated with condensing the sulfur. The second concept involved desulfurization using CeO2 and regeneration of the sulfided sorbent, Ce2O2S, using SO2 to produce elemental sulfur directly. No significant side reactions were observed and the reaction was found to be quite rapid over the temperature range of 500°C to 700°C. Elemental sulfur concentrations (as S2) as large as 20 mol% were produced. Limitations associated with the cerium sorbent process are concentrated in the desulfurization phase. High temperature and highly reducing coal gas such as produced in the Shell gasification process are required if high sulfur removal efficiencies are to be achieved. For example, the equilibrium H2S concentration at 800°C from a Shell gas in contact with CeO2 is about 300 ppmv, well above the allowable IGCC specification. In this case, a two-stage desulfurization process using CeO2 for bulk H2S removal following by a zinc sorbent polishing step would be required. Under appropriate conditions, however, CeO2 can be reduced to non-stoichiometric CeOn (n<2) which has significantly greater affinity for H2S. Pre-breakthrough H2S concentrations in the range of 1 ppmv to 5 ppmv were measured in sulfidation tests using CeOn at 700°C in highly reducing gases, as measured by equilibrium O2 concentration, comparable to the Shell gas. Good sorbent durability was indicated in

  15. Advanced sulfur control concepts for hot-gas desulfurization technology

    International Nuclear Information System (INIS)

    Lopez Ortiz, A.; Harrison, D.P.; Groves, F.R.; White, J.D.; Zhang, S.; Huang, W.N.; Zeng, Y.

    1998-01-01

    This research project examined the feasibility of a second generation high-temperature coal gas desulfurization process in which elemental sulfur is produced directly during the sorbent regeneration phase. Two concepts were evaluated experimentally. In the first, FeS was regenerated in a H2O-O2 mixture. Large fractions of the sulfur were liberated in elemental form when the H2O-O2 ratio was large. However, the mole percent of elemental sulfur in the product was always quite small (<<1%) and a process based on this concept was judged to be impractical because of the low temperature and high energy requirements associated with condensing the sulfur. The second concept involved desulfurization using CeO2 and regeneration of the sulfided sorbent, Ce2O2S, using SO2 to produce elemental sulfur directly. No significant side reactions were observed and the reaction was found to be quite rapid over the temperature range of 500C to 700C. Elemental sulfur concentrations (as S2) as large as 20 mol% were produced. Limitations associated with the cerium sorbent process are concentrated in the desulfurization phase. High temperature and highly reducing coal gas such as produced in the Shell gasification process are required if high sulfur removal efficiencies are to be achieved. For example, the equilibrium H2S concentration at 800C from a Shell gas in contact with CeO2 is about 300 ppmv, well above the allowable IGCC specification. In this case, a two-stage desulfurization process using CeO2 for bulk H2S removal following by a zinc sorbent polishing step would be required. Under appropriate conditions, however, CeO2 can be reduced to non-stoichiometric CeOn (n<2) which has significantly greater affinity for H2S. Pre-breakthrough H2S concentrations in the range of 1 ppmv to 5 ppmv were measured in sulfidation tests using CeOn at 700C in highly reducing gases, as measured by equilibrium O2 concentration, comparable to the Shell gas. Good sorbent durability was indicated in a

  16. Advanced reactor design study. Assessing nonbackfittable concepts for improving uranium utilization in light water reactors

    International Nuclear Information System (INIS)

    Fleischman, R.M.; Goldsmith, S.; Newman, D.F.; Trapp, T.J.; Spinrad, B.I.

    1981-09-01

    The objective of the Advanced Reactor Design Study (ARDS) is to identify and evaluate nonbackfittable concepts for improving uranium utilization in light water reactors (LWRs). The results of this study provide a basis for selecting and demonstrating specific nonbackfittable concepts that have good potential for implementation. Lead responsibility for managing the study was assigned to the Pacific Northwest Laboratory (PNL). Nonbackfittable concepts for improving uranium utilization in LWRs on the once-through fuel cycle were selected separately for PWRs and BWRs due to basic differences in the way specific concepts apply to those plants. Nonbackfittable concepts are those that are too costly to incorporate in existing plants, and thus, could only be economically incorporated in new reactor designs or plants in very early stages of construction. Essential results of the Advanced Reactor Design Study are summarized

  17. Advances in nuclear fuel cycle materials and concepts. Vol. 1

    International Nuclear Information System (INIS)

    El-Sayed, A.A.

    1996-01-01

    This presentation gives an overview of the new trends in the materials used in various steps of the nuclear fuel cycle. This will cover fuels for various types of reactors (PWRs, HTRs, ... etc.) cladding materials, control rod materials, reactor structural materials, as well as materials used in the back end of the fuel cycle. Problems associated with corrosion of fuel cladding materials as well as those in control rod materials (B 4 C swelling...etc.), and approaches for combating these influences are reviewed. For the case of reactor pressure vessel materials issues related to the influences of alloy composition, design approaches including the use of more forged parts and minimizing, as for as possible, longitudinal welds especially in the central region, are discussed. Furthermore the application of techniques for recovery of pre-irradiation mechanical properties of PVS components is also covered. New candidate materials for the construction of high level waste containers including modified types of stainless steel (high Ni and high MO), nickel-base alloys and titanium alloys are also detailed. Finally, nuclear fuel cycle concepts involving plutonium and actinides recycling shall be reviewed. 28 figs., 6 tabs

  18. Advances in nuclear fuel cycle materials and concepts. Vol. 1

    Energy Technology Data Exchange (ETDEWEB)

    El-Sayed, A A [Materials Division, Nuclear Research Centre, Atomic Energy Authority, Cairo (Egypt)

    1996-03-01

    This presentation gives an overview of the new trends in the materials used in various steps of the nuclear fuel cycle. This will cover fuels for various types of reactors (PWRs, HTRs, ... etc.) cladding materials, control rod materials, reactor structural materials, as well as materials used in the back end of the fuel cycle. Problems associated with corrosion of fuel cladding materials as well as those in control rod materials (B{sub 4} C swelling...etc.), and approaches for combating these influences are reviewed. For the case of reactor pressure vessel materials issues related to the influences of alloy composition, design approaches including the use of more forged parts and minimizing, as for as possible, longitudinal welds especially in the central region, are discussed. Furthermore the application of techniques for recovery of pre-irradiation mechanical properties of PVS components is also covered. New candidate materials for the construction of high level waste containers including modified types of stainless steel (high Ni and high MO), nickel-base alloys and titanium alloys are also detailed. Finally, nuclear fuel cycle concepts involving plutonium and actinides recycling shall be reviewed. 28 figs., 6 tabs.

  19. Prescriptive concepts for advanced nuclear materials control and accountability systems

    International Nuclear Information System (INIS)

    Whitty, W.J.; Strittmatter, R.B.; Ford, W.; Tisinger, R.M.; Meyer, T.H.

    1987-06-01

    Networking- and distributed-processing hardware and software have the potential of greatly enhancing nuclear materials control and accountability (MC and A) systems, from both safeguards and process operations perspectives, while allowing timely integrated safeguards activities and enhanced computer security at reasonable cost. A hierarchical distributed system is proposed consisting of groups of terminal and instruments in plant production and support areas connected to microprocessors that are connected to either larger microprocessors or minicomputers. These micros and/or minis are connected to a main machine, which might be either a mainframe or a super minicomputer. Data acquisition, preliminary input data validation, and transaction processing occur at the lowest level. Transaction buffering, resource sharing, and selected data processing occur at the intermediate level. The host computer maintains overall control of the data base and provides routine safeguards and security reporting and special safeguards analyses. The research described outlines the distribution of MC and A system requirements in the hierarchical system and distributed processing applied to MC and A. Implications of integrated safeguards and computer security concepts for the distributed system design are discussed. 10 refs., 4 figs

  20. HERCULES Advanced Combustion Concepts Test Facility: Spray/Combustion Chamber

    Energy Technology Data Exchange (ETDEWEB)

    Herrmann, K. [Eidgenoessische Technische Hochschule (ETH), Labor fuer Aerothermochemie und Verbrennungssysteme, Zuerich (Switzerland)

    2004-07-01

    This yearly report for 2004 on behalf of the Swiss Federal Office of Energy (SFOE) at the Laboratory for Aero-thermochemistry and Combustion Systems at the Federal Institute of Technology ETH in Zurich, Switzerland, presents a review of work being done within the framework of HERCULES (High Efficiency R and D on Combustion with Ultra Low Emissions for Ships) - the international R and D project concerning new technologies for ships' diesels. The work involves the use and augmentation of simulation models. These are to be validated using experimental data. The report deals with the development of an experimental set-up that will simulate combustion in large two-stroke diesel engines and allow the generation of reference data. The main element of the test apparatus is a spray / combustion chamber with extensive possibilities for optical observation under variable flow conditions. The results of first simulations confirm concepts and shall help in further work on the project. The potential offered by high-speed camera systems was tested using the institute's existing HTDZ combustion chamber. Further work to be done is reviewed.

  1. Advanced Nuclear Power Concepts for Human Exploration Missions

    International Nuclear Information System (INIS)

    Robert L. Cataldo; Lee S. Mason

    2000-01-01

    The design reference mission for the National Aeronautics and Space Administration's (NASA's) human mission to Mars supports a philosophy of living off the land in order to reduce crew risk, launch mass, and life-cycle costs associated with logistics resupply to a Mars base. Life-support materials, oxygen, water, and buffer gases, and the crew's ascent-stage propellant would not be brought from Earth but rather manufactured from the Mars atmosphere. The propellants would be made over ∼2 yr, the time between Mars mission launch window opportunities. The production of propellants is very power intensive and depends on type, amount, and time to produce the propellants. Closed-loop life support and food production are also power intensive. With the base having several habitats, a greenhouse, and propellant production capability, total power levels reach well over 125 kW(electric). The most mass-efficient means of satisfying these requirements is through the use of nuclear power. Studies have been performed to identify a potential system concept, described in this paper, using a mobile cart to transport the power system away from the Mars lander and provide adequate separation between the reactor and crew. The studies included an assessment of reactor and power conversion technology options, selection of system and component redundancy, determination of optimum separation distance, and system performance sensitivity to some key operating parameters

  2. Priorities for Advancing the Concept of New Ruralism

    Directory of Open Access Journals (Sweden)

    Galen Newman

    2016-03-01

    Full Text Available Civic expansion and land use migrations to urban peripheries can accelerate the conversion of agricultural land uses. Widespread trepidation concerning urban sprawl has led to innovative frameworks for conserving or enhancing farmland. New Ruralism is one such framework, linking farmland preservation with developmental plans to reduce farmland conversion and low density development. Although the concept is still evolving, recent support for New Ruralism has grown. One of the most important factors in creating a New Ruralism-based development is coherent policy for permanent agricultural preserves. These preserves require the simultaneous, careful planning of land preservation balanced with the location of future development. This paper discusses the current condition of farmland loss and reviews issues and challenges associated with farmland preservation with existing New Ruralism developments. The goal is to synthesize this information into recommendations for increasing farmland preservation opportunities in New Ruralism-based developments. A more comprehensive definition for New Ruralism is presented, accompanied by several priorities for maximizing the economic, environmental, and cultural viability of New Ruralism-based farmland preserves.

  3. Advanced electric propulsion system concept for electric vehicles

    Science.gov (United States)

    Raynard, A. E.; Forbes, F. E.

    1979-01-01

    Seventeen propulsion system concepts for electric vehicles were compared to determine the differences in components and battery pack to achieve the basic performance level. Design tradeoffs were made for selected configurations to find the optimum component characteristics required to meet all performance goals. The anticipated performance when using nickel-zinc batteries rather than the standard lead-acid batteries was also evaluated. The two systems selected for the final conceptual design studies included a system with a flywheel energy storage unit and a basic system that did not have a flywheel. The flywheel system meets the range requirement with either lead-acid or nickel-zinc batteries and also the acceleration of zero to 89 km/hr in 15 s. The basic system can also meet the required performance with a fully charged battery, but, when the battery approaches 20 to 30 percent depth of discharge, maximum acceleration capability gradually degrades. The flywheel system has an estimated life-cycle cost of $0.041/km using lead-acid batteries. The basic system has a life-cycle cost of $0.06/km. The basic system, using batteries meeting ISOA goals, would have a life-cycle cost of $0.043/km.

  4. Effect of the CTL proliferation program on virus dynamics

    DEFF Research Database (Denmark)

    Wodarz, Dominik; Thomsen, Allan Randrup

    2005-01-01

    Experiments have established that CTLs do not require continuous antigenic stimulation for expansion. Instead, responses develop by a process of programmed proliferation which involves approximately 7-10 antigen-independent cell divisions, the generation of effector cells and the differentiation...... virus loads and thus acute symptoms. The reason is that the programmed divisions are independent from antigenic stimulation, and an increase in virus load does not speed up the rate of CTL expansion. We hypothesize that the 7-10 programmed divisions observed in vivo represent an optimal solution...... into memory cells. The effect of this program on the infection dynamics and the advantages gained by the program have, however, not been explored yet. We investigate this with mathematical models. We find that more programmed divisions can make virus clearance more efficient because CTL division continues...

  5. Advanced Direct Liquefaction Concepts for PETC Generic Units - Phase II

    Energy Technology Data Exchange (ETDEWEB)

    None

    1997-09-01

    Reported here are the results of Laboratory and Bench- Scale experiments and supporting technical and economic assessments conducted under DOE Contract No. DE- AC22- 91PC91040 during the period April 1, 1997 to June 30, 1997. This contract is with the University of Kentucky Research Foundation which supports work with the University of Kentucky Center for Applied Energy Research, CONSOL, Inc., LDP Associates, and Hydrocarbon Technologies, Inc. This work involves the introduction into the basic two stage liquefaction process several novel concepts which includes dispersed lower- cost catalysts, coal cleaning by oil agglomeration, and distillate hydrotreating and dewaxing. This report includes a data analysis of the ALC- 2 run which was the second continuous run in which Wyodak Black Thunder coal was fed to a two kg/ h bench- scale unit. One of the objectives of that run was to determine the relative activity of several Mo- based coal impregnated catalyst precursors. The precursors included ammonium heptamolybdate (100 mg Mo/ kg dry coal), which was used alone as well as in combination with ferrous sulfate (1% Fe/ dry coal) and nickel sulfate (50 mg Ni/ kg dry coal). The fourth precursor that was tested was phosphomolybdic acid which was used at a level of 100 mg Mo/ kg dry coal. Because of difficulties in effectively separating solids from the product stream, considerable variation in the feed stream occurred. Although the coal feed rate was nearly constant, the amount of recycle solvent varied which resulted in wide variations of resid, unconverted coal and mineral matter in the feed stream. Unfortunately, steady state was not achieved in any of the four conditions that were run. Earlier it was reported that Ni- Mo catalyst appeared to give the best results based upon speculative steady- state yields that were developed.

  6. Advanced composite structural concepts and material technologies for primary aircraft structures

    Science.gov (United States)

    Jackson, Anthony

    1991-01-01

    Structural weight savings using advanced composites have been demonstrated for many years. Most military aircraft today use these materials extensively and Europe has taken the lead in their use in commercial aircraft primary structures. A major inhibiter to the use of advanced composites in the United States is cost. Material costs are high and will remain high relative to aluminum. The key therefore lies in the significant reduction in fabrication and assembly costs. The largest cost in most structures today is assembly. As part of the NASA Advanced Composite Technology Program, Lockheed Aeronautical Systems Company has a contract to explore and develop advanced structural and manufacturing concepts using advanced composites for transport aircraft. Wing and fuselage concepts and related trade studies are discussed. These concepts are intended to lower cost and weight through the use of innovative material forms, processes, structural configurations and minimization of parts. The approach to the trade studies and the downselect to the primary wing and fuselage concepts is detailed. The expectations for the development of these concepts is reviewed.

  7. RASC-AL (Revolutionary Aerospace Systems Concepts-Academic Linkage): 2002 Advanced Concept Design Presentation

    Science.gov (United States)

    2002-01-01

    The Revolutionary Aerospace Systems Concepts-Academic Linkage (RASC-AL) is a program of the Lunar and Planetary Institute (LPI) in collaboration with the Universities Space Research Association's (USRA) ICASE institute through the NASA Langley Research Center. The RASC-AL key objectives are to develop relationships between universities and NASA that lead to opportunities for future NASA research and programs, and to develop aerospace systems concepts and technology requirements to enable future NASA missions. The program seeks to look decades into the future to explore new mission capabilities and discover what's possible. NASA seeks concepts and technologies that can make it possible to go anywhere, at anytime, safely, reliably, and affordably to accomplish strategic goals for science, exploration, and commercialization. University teams were invited to submit research topics from the following themes: Human and Robotic Space Exploration, Orbital Aggregation & Space Infrastructure Systems (OASIS), Zero-Emissions Aircraft, and Remote Sensing. RASC-AL is an outgrowth of the HEDS-UP (University Partners) Program sponsored by the LPI. HEDS-UP was a program of the Lunar and Planetary Institute designed to link universities with NASA's Human Exploration and Development of Space (HEDS) enterprise. The first RASC-AL Forum was held November 5-8, 2002, at the Hilton Cocoa Beach Oceanfront Hotel in Cocoa Beach, Florida. Representatives from 10 university teams presented student research design projects at this year's Forum. Each team contributed a written report and these reports are presented.

  8. Concept and viability of androgen annihilation for advanced prostate cancer.

    Science.gov (United States)

    Mohler, James L

    2014-09-01

    There remains no standard of care for patients with a rising prostate-specific antigen level after radical prostatectomy or radiotherapy but who have no radiographic metastases, even though this is the second largest group of patients with prostate cancer (CaP) in the United States. Androgen deprivation therapy (ADT) may cure some men with advanced CaP based on single-institution series and a randomized clinical trial of immediate versus delayed ADT for men found to have pelvic lymph node metastasis at the time of radical prostatectomy. ADT may be more effective when initiated for minimal disease burden, which can be detected using PSA after radical prostatectomy or radiotherapy, and if more complete disruption of the androgen axis using newer agents decreases the chance that androgen-sensitive cells survive to adapt to a low-androgen environment. Androgens may be "annihilated" simultaneously using a luteinizing hormone-releasing hormone antagonist or agonist to inhibit testicular production of testosterone, a P45017A1 (CYP17A1) inhibitor to diminish metabolism of testosterone via the adrenal pathway and dihydrotestosterone (DHT) via the backdoor pathway, a 5α-reductase (SRD5A) inhibitor to diminish testosterone reduction to DHT and backdoor metabolism of progesterone substrates to DHT, and a newer antiandrogen to compete better with DHT for the androgen receptor ligand-binding domain. Early initiation of androgen annihilation for induction as part of planned intermittent ADT should be safe, may reduce tumor burden below a threshold that allows eradication by the immune system, and may cure many men who have failed definitive local therapy. © 2014 American Cancer Society.

  9. Earth's Critical Zone and hydropedology: concepts, characteristics, and advances

    Science.gov (United States)

    Lin, H.

    2010-01-01

    The Critical Zone (CZ) is a holistic framework for integrated studies of water with soil, rock, air, and biotic resources in the near-surface terrestrial environment. This most heterogeneous and complex region of the Earth ranges from the vegetation top to the aquifer bottom, with a highly variable thickness globally and a yet-to-be clearly defined lower boundary of active water cycle. Interfaces among different compartments in the CZ are critical, which provide fertile ground for interdisciplinary research. The reconciliation of coupled geological and biological cycles (vastly different in space and time scales) is essential to understanding the complexity and evolution of the CZ. Irreversible evolution, coupled cycling, interactive layers, and hierarchical heterogeneity are the characteristics of the CZ, suggesting that forcing, coupling, interfacing, and scaling are grand challenges for advancing CZ science. Hydropedology - the science of the behaviour and distribution of soil-water interactions in contact with mineral and biological materials in the CZ - is an important contributor to CZ study. The pedosphere is the foundation of the CZ, which represents a geomembrance across which water and solutes, as well as energy, gases, solids, and organisms are actively exchanged with the atmosphere, biosphere, hydrosphere, and lithosphere, thereby creating a life-sustaining environment. Hydropedology emphasizes in situ soils in the landscape setting, where distinct pedogenic features and soil-landscape relationships are essential to understanding interactive pedologic and hydrologic processes. Both CZ science and hydropedology embrace an evolutionary and holistic worldview, which offers stimulating opportunities through steps such as integrated systems approach, evolutionary mapping-monitoring-modeling framework, and fostering a global alliance. Our capability to predict the behaviour and evolution of the CZ in response to changing environment can be significantly

  10. Earth's Critical Zone and hydropedology: concepts, characteristics, and advances

    Directory of Open Access Journals (Sweden)

    H. Lin

    2010-01-01

    Full Text Available The Critical Zone (CZ is a holistic framework for integrated studies of water with soil, rock, air, and biotic resources in the near-surface terrestrial environment. This most heterogeneous and complex region of the Earth ranges from the vegetation top to the aquifer bottom, with a highly variable thickness globally and a yet-to-be clearly defined lower boundary of active water cycle. Interfaces among different compartments in the CZ are critical, which provide fertile ground for interdisciplinary research. The reconciliation of coupled geological and biological cycles (vastly different in space and time scales is essential to understanding the complexity and evolution of the CZ. Irreversible evolution, coupled cycling, interactive layers, and hierarchical heterogeneity are the characteristics of the CZ, suggesting that forcing, coupling, interfacing, and scaling are grand challenges for advancing CZ science. Hydropedology – the science of the behaviour and distribution of soil-water interactions in contact with mineral and biological materials in the CZ – is an important contributor to CZ study. The pedosphere is the foundation of the CZ, which represents a geomembrance across which water and solutes, as well as energy, gases, solids, and organisms are actively exchanged with the atmosphere, biosphere, hydrosphere, and lithosphere, thereby creating a life-sustaining environment. Hydropedology emphasizes in situ soils in the landscape setting, where distinct pedogenic features and soil-landscape relationships are essential to understanding interactive pedologic and hydrologic processes. Both CZ science and hydropedology embrace an evolutionary and holistic worldview, which offers stimulating opportunities through steps such as integrated systems approach, evolutionary mapping-monitoring-modeling framework, and fostering a global alliance. Our capability to predict the behaviour and evolution of the CZ in response to changing environment can

  11. Advanced Direct Liquefaction Concepts for PETC Generic Units - Phase II

    Energy Technology Data Exchange (ETDEWEB)

    None

    1997-12-01

    The results of Laboratory and Bench-Scale experiments and supporting technical and economic assessments conducted under DOE Contract No. DE-AC22-91PC91040 are reported for the period July 1, 1997 to September 30, 1997. This contract is with the University of Kentucky Research Foundation which supports work with the University of Kentucky Center for Applied Energy Research, CONSOL, Inc., LDP Associates, and Hydrocarbon Technologies, Inc. This work involves the introduction into the basic two stage liquefaction process several novel concepts which include dispersed lower-cost catalysts, coal cleaning by oil agglomeration, and distillate hydrotreating and dewaxing. Results are reported from experiments in which various methods were tested to activate dispersed Mo precursors. Several oxothiomolybdates precursors having S/Mo ratios from two to six were prepared. Another having a S/Mo ratio of eleven was also prepared that contained an excess of sulfur. In the catalyst screening test, none of these precursors exhibited an activity enhancement that might suggest that adding sulfur into the structure of the Mo precursors would be beneficial to the process. In another series of experiments, AHM impregnated coal slurried in the reaction mixture was pretreated withH S/H under pressure and successively heated for 30 min at 120, 250 2 2 and 360 C. THF conversions in the catalyst screening test were not affected while resid conversions o increased such that pretreated coals impregnated with 100 ppm Mo gave conversions equivalent to untreated coals impregnated with 300 ppm fresh Mo. Cobalt, nickel and potassium phosphomolybdates were prepared and tested as bimetallic precursors. The thermal stability of these compounds was evaluated in TG/MS to determine whether the presence of the added metal would stabilize the Keggin structure at reaction temperature. Coals impregnated with these salts showed the Ni and Co salts gave the same THF conversion as PMA while the Ni salt gave higher

  12. The Effect of CTL Approach Based on NHT Learning Model toward Students’ motivation, Science Achievement, and Retention

    Directory of Open Access Journals (Sweden)

    Muhammad Mifta Fausan

    2017-07-01

    Full Text Available The learning is an interaction process between students and their environment in order to improve good behavior. The results of observation which has been done in grade V SDN No. 4 Tanjung Batu showed that the students’ motivation and science achievement were low. This was becaused by the learning process which was still product oriented (based on material content, consequently, this lead to limit the learning is merely on memorizing concept activities. One of the learning approach that can be used to solve this problem is the Contextual Teaching and Learning (CTL based on Numbered Head Together (NHT. This research aims to determine the effect of CTL based on NHT toward student’s motivation, science achievement, and retention. Subjects in this research were the students of grade V SDN No. 4 Tanjung Batu. This research is a quasi-experimental using post-test only control design. The data obtained were analyzed by using descriptive and inferential statistical analysis. The research instruments were observation sheets and written test. The results showed that there was significant effect of CTL based on NHT toward students’ motivation, science achievement, and retention. It can be seen from the independent sample t-test results which showed significant value less than 0.05.

  13. Advanced concept of reduced-moderation water reactor (RMWR) for plutonium multiple recycling

    International Nuclear Information System (INIS)

    Okubo, T.; Iwamura, T.; Takeda, R.; Yamamoto, K.; Okada, H.

    2001-01-01

    An advanced water-cooled reactor concept named the Reduced-Moderation Water Reactor (RMWR) has been proposed to attain a high conversion ratio more than 1.0 and to achieve the negative void reactivity coefficient. At present, several types of design concepts satisfying both the design targets have been proposed based on the evaluation for the fuel without fission products and minor actinides. In this paper, the feasibility of the RMWR core is investigated for the plutonium multiple recycling under advanced reprocessing schemes with low decontamination factors as proposed for the FBR fuel cycle. (author)

  14. Core mechanics and configuration behavior of advanced LMFBR core restraint concepts

    International Nuclear Information System (INIS)

    Fox, J.N.; Wei, B.C.

    1978-02-01

    Core restraint systems in LMFBRs maintain control of core mechanics and configuration behavior. Core restraint design is complex due to the close spacing between adjacent components, flux and temperature gradients, and irradiation-induced material property effects. Since the core assemblies interact with each other and transmit loads directly to the core restraint structural members, the core assemblies themselves are an integral part of the core restraint system. This paper presents an assessment of several advanced core restraint system and core assembly concepts relative to the expected performance of currently accepted designs. A recommended order for the development of the advanced concepts is also presented

  15. Proceedings of the Workshop on Advanced Network and Technology Concepts for Mobile, Micro, and Personal Communications

    Science.gov (United States)

    Paul, Lori (Editor)

    1991-01-01

    The Workshop on Advanced Network and Technology Concepts for Mobile, Micro, and Personal Communications was held at NASA's JPL Laboratory on 30-31 May 1991. It provided a forum for reviewing the development of advanced network and technology concepts for turn-of-the-century telecommunications. The workshop was organized into three main categories: (1) Satellite-Based Networks (L-band, C-band, Ku-band, and Ka-band); (2) Terrestrial-Based Networks (cellular, CT2, PCN, GSM, and other networks); and (3) Hybrid Satellite/Terrestrial Networks. The proceedings contain presentation papers from each of the above categories.

  16. A Concept Plane using electric distributed propulsion Evaluation of advanced power architecture

    OpenAIRE

    Ridel , M.; Paluch , B.; Doll , C.; Donjat , D.; Hermetz , J.; Guigon , A.; Schmollgruber , P.; Atinault , O.; Choy , P.; Le Tallec , P.; Dessornes , O.; Lefebvre , T.

    2015-01-01

    International audience; Starting from electrical distributed propulsion system concept, the ONERA’s engineers demonstrated the viability of an all electrical aircraft for a small business aircraft. This paper describes the advanced power architecture considering energy conversion and power distribution. The design of this advanced power architecture requires the multi-physic integration of different domains as flight performances, safety and environmental requirements (thermal, electric, elec...

  17. Development of a metal-clad advanced composite shear web design concept

    Science.gov (United States)

    Laakso, J. H.

    1974-01-01

    An advanced composite web concept was developed for potential application to the Space Shuttle Orbiter main engine thrust structure. The program consisted of design synthesis, analysis, detail design, element testing, and large scale component testing. A concept was sought that offered significant weight saving by the use of Boron/Epoxy (B/E) reinforced titanium plate structure. The desired concept was one that was practical and that utilized metal to efficiently improve structural reliability. The resulting development of a unique titanium-clad B/E shear web design concept is described. Three large scale components were fabricated and tested to demonstrate the performance of the concept: a titanium-clad plus or minus 45 deg B/E web laminate stiffened with vertical B/E reinforced aluminum stiffeners.

  18. An Exploration of Learners' Conceptions of Language, Culture, and Learning in Advanced-Level Spanish Courses

    Science.gov (United States)

    Drewelow, Isabelle; Mitchell, Claire

    2015-01-01

    This article reports on an exploratory study, which examines learners' rating of culture in relation to other concepts in advanced Spanish courses and their justification of the ratings attributed. Open-ended responses, elicited from a questionnaire completed by 179 respondents, were analysed line by line using an interpretive approach. Data…

  19. Teaching Advanced Concepts in Computer Networks: VNUML-UM Virtualization Tool

    Science.gov (United States)

    Ruiz-Martinez, A.; Pereniguez-Garcia, F.; Marin-Lopez, R.; Ruiz-Martinez, P. M.; Skarmeta-Gomez, A. F.

    2013-01-01

    In the teaching of computer networks the main problem that arises is the high price and limited number of network devices the students can work with in the laboratories. Nowadays, with virtualization we can overcome this limitation. In this paper, we present a methodology that allows students to learn advanced computer network concepts through…

  20. Effects of Advance Organizer Instruction on Preschool Children's Learning of Musical Concepts.

    Science.gov (United States)

    Lawton, Joseph T.; Johnson, Ann

    1992-01-01

    Presents results of a study of the effects of advance organizer instruction on preschool children's learning of the musical concepts of dynamics, pitch, tempo, and rhythm. Reports that three modes and three methods of presentation were evaluated. Concludes that, although results did vary with mode, the method of presentation had no significant…

  1. Advanced Planning Concepts in the Closed-Loop Container Network of ARN

    NARCIS (Netherlands)

    Le Blanc, H.M.; van Krieken, M.G.C.; Krikke, H.R.; Fleuren, H.A.

    2004-01-01

    In this paper we discuss a real-life case study in the optimization of the logistics network for the collection of containers from end-of-life vehicle dismantlers in the Netherlands.Advanced planning concepts like dynamic assignment of dismantlers to logistic service providers are analyzed by a

  2. Summary Report of Working Group 7: Muon Colliders and Advanced Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Nagaitsev, Sergei [Fermilab; Berg, J.Scott [Brookhaven

    2012-07-01

    The primary subject of working group 7 at the 2012 Advanced Accelerator Concepts Workshop was muon accelerators for a muon collider or neutrino factory. Additionally, this working group included topics that did not fit well into other working groups. Two subjects were discussed by more than one speaker: lattices to create a perfectly integrable nonlinear lattice, and a Penning trap to create antihydrogen.

  3. Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

    Science.gov (United States)

    Crabtree, John; Zhang, Xihui

    2015-01-01

    Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We…

  4. Conceptual study of advanced PWR systems. A study of passive and inherent safety design concepts for advanced light water reactors

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Soon Heung; No, Hee Cheon; Baek, Won Pil; Jae, Shim Young; Lee, Goung Jin; Na, Man Gyun; Lee, Jae Young; Kim, Han Gon; Kang, Ki Sig; Moon, Sang Ki; Kim, Yun Il; Park, Jae Wook; Yang, Soo Hyung; Kim, Soo Hyung; Lee, Seong Wook; Kim, Hong Che; Park, Hyun Sik; Jeong, Ji Hwan; Lee, Sang Il; Jung, Hae Yong; Kim, Hyong Tae; Chae, Kyung Sun; Moon, Ki Hoon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1995-08-01

    The five thermal-hydraulic concepts chosen for advanced PWR have been studied as follows: (1) Critical Heat Flux: Review of previous works, analysis of parametric trends, analysis of transient CHF characteristics, extension of the CHF date bank, survey and assessment of correlations, design of a intermediate-pressure CHF test loop have been performed. (2) Passive Cooling Concepts for Concrete Containment system: Review of condensation phenomena with noncondensable gases, selection of a promising concept (i.e., use of external condensers), design of test loop according to scaling laws have been accomplished. and computer programs based on the control-volume approach, and the conceptual design of test loop have been accomplished. (4) Fluidic Diode Concepts: Review of previous applications of the concept, analysis major parameters affecting the performance, development of a computational code, and conceptual investigation of the verification test loop have been performed. (5) Wet Thermal Insulator: Review of previous works, selection of promising methods ( i.e. ceramic fiber in a steel case and mirror-type insulator), and conceptual design of the experimental loop have been performed. (author). 9 refs.

  5. Modified-open fuel cycle performance with breed-and-burn advanced reactor concepts

    International Nuclear Information System (INIS)

    Heidet, Florent; Kim, Taek K.; Taiwo, Temitope A.

    2011-01-01

    Recent advances in fast reactor designs enable significant increase in the uranium utilization in an advanced fuel cycle. The category of fast reactors, collectively termed breed-and-burn reactor concepts, can use a large amount of depleted uranium as fuel without requiring enrichment with the exception of the initial core critical loading. Among those advanced concepts, some are foreseen to operate within a once-through fuel cycle such as the Traveling Wave Reactor, CANDLE reactor or Ultra-Long Life Fast Reactor, while others are intended to operate within a modified-open fuel cycle, such as the Breed-and-Burn reactor and the Energy Multiplier Module. This study assesses and compares the performance of the latter category of breed-and-burn reactors at equilibrium state. It is found that the two reactor concepts operating within a modified-open fuel cycle can significantly improve the sustainability and security of the nuclear fuel cycle by decreasing the uranium resources and enrichment requirements even further than the breed-and-burn core concepts operating within the once-through fuel cycle. Their waste characteristics per unit of energy are also found to be favorable, compared to that of currently operating PWRs. However, a number of feasibility issues need to be addressed in order to enable deployment of these breed-and-burn reactor concepts. (author)

  6. Design concepts and advanced manipulator development for nuclear fuel cycle facilities

    International Nuclear Information System (INIS)

    Feldman, M.J.

    1985-01-01

    In the Fuel Recycle Division, Consolidated Fuel Reprocessing Program at the Oak Ridge National Laboratory, a comprehensive remote systems development program has existed for the past seven years. The new remote technology under development is expected to significantly improve remote operations by extending the range of tasks accomplished by remote means and increasing the efficiency of remote work undertaken. The application of advanced manipulation is viewed as an essential part of a series of design directions whose sum describes a somewhat unique blend of old and new technology. A design direction based upon the Teletec concept is explained and recent progress in the development of an advanced servomanipulator-based maintenance concept is summarized to show that a new generation of remote systems is feasible through advanced technology. 14 refs., 14 figs

  7. Proposal for a advanced PWR core with adequate characteristics for passive safety concept

    International Nuclear Information System (INIS)

    Perrotta, Jose Augusto

    1999-01-01

    This work presents a discussion upon the suitable from an advanced PWR core, classified by the EPRI as 'Passive PWR' (advanced reactor with passive safety concept to power plants with less than 600 MW electrical power). The discussion upon the type of core is based on nuclear fuel engineering concepts. Discussion is made on type of fuel materials, structural materials, geometric shapes and manufacturing process that are suitable to produce fuel assemblies which give good performance for this type of reactors. The analysis is guided by the EPRI requirements for Advanced Light Water Reactor (ALWR). By means of comparison, the analysis were done to Angra 1 (old type of 600 MWe PWR class), and the design of the Westinghouse Advanced PWR-AP600. It was verified as a conclusion of this work that the modern PWR fuels are suitable for advanced PWR's Nevertheless, this work presents a technical alternative to this kind of fuel, still using UO 2 as fuel, but changing its cylindrical form of pellets and pin type fuel element to plane shape pallets and plate type fuel element. This is not a novelty fuel, since it was used in the 50's at Shippingport Reactor and as an advanced version by CEA of France in the 70's. In this work it is proposed a new mechanical assembly design for this fuel, which can give adequate safety and operational performance to the core of a 'Passive PWR'. (author)

  8. Advanced Spacesuit Portable Life Support System Packaging Concept Mock-Up Design & Development

    Science.gov (United States)

    O''Connell, Mary K.; Slade, Howard G.; Stinson, Richard G.

    1998-01-01

    A concentrated development effort was begun at NASA Johnson Space Center to create an advanced Portable Life Support System (PLSS) packaging concept. Ease of maintenance, technological flexibility, low weight, and minimal volume are targeted in the design of future micro-gravity and planetary PLSS configurations. Three main design concepts emerged from conceptual design techniques and were carried forth into detailed design, then full scale mock-up creation. "Foam", "Motherboard", and "LEGOtm" packaging design concepts are described in detail. Results of the evaluation process targeted maintenance, robustness, mass properties, and flexibility as key aspects to a new PLSS packaging configuration. The various design tools used to evolve concepts into high fidelity mock ups revealed that no single tool was all encompassing, several combinations were complimentary, the devil is in the details, and, despite efforts, many lessons were learned only after working with hardware.

  9. Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm

    Science.gov (United States)

    Robinson, John W.; McCleskey, Carey M.; Rhodes, Russel E.; Lepsch, Roger A.; Henderson, Edward M.; Joyner, Claude R., III; Levack, Daniel J. H.

    2013-01-01

    This paper describes Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm. It builds on the work of the previous paper "Approach to an Affordable and Productive Space Transportation System". The scope includes both flight and ground system elements, and focuses on their compatibility and capability to achieve a technical solution that is operationally productive and also affordable. A clear and revolutionary approach, including advanced propulsion systems (advanced LOX rich booster engine concept having independent LOX and fuel cooling systems, thrust augmentation with LOX rich boost and fuel rich operation at altitude), improved vehicle concepts (autogeneous pressurization, turbo alternator for electric power during ascent, hot gases to purge system and keep moisture out), and ground delivery systems, was examined. Previous papers by the authors and other members of the Space Propulsion Synergy Team (SPST) focused on space flight system engineering methods, along with operationally efficient propulsion system concepts and technologies. This paper continues the previous work by exploring the propulsion technology aspects in more depth and how they may enable the vehicle designs from the previous paper. Subsequent papers will explore the vehicle design, the ground support system, and the operations aspects of the new delivery paradigm in greater detail.

  10. A Framework for Human Performance Criteria for Advanced Reactor Operational Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Jacques V Hugo; David I Gertman; Jeffrey C Joe

    2014-08-01

    This report supports the determination of new Operational Concept models needed in support of the operational design of new reactors. The objective of this research is to establish the technical bases for human performance and human performance criteria frameworks, models, and guidance for operational concepts for advanced reactor designs. The report includes a discussion of operating principles for advanced reactors, the human performance issues and requirements for human performance based upon work domain analysis and current regulatory requirements, and a description of general human performance criteria. The major findings and key observations to date are that there is some operating experience that informs operational concepts for baseline designs for SFR and HGTRs, with the Experimental Breeder Reactor-II (EBR-II) as a best-case predecessor design. This report summarizes the theoretical and operational foundations for the development of a framework and model for human performance criteria that will influence the development of future Operational Concepts. The report also highlights issues associated with advanced reactor design and clarifies and codifies the identified aspects of technology and operating scenarios.

  11. Engineering a CTL-Tailored Replicon RNA Vaccine against PRRSV

    DEFF Research Database (Denmark)

    Welner, Simon; Werder, Simea; Nielsen, Morten

    The development of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV) has been hampered by the high mutation rate and the multiple immunoevasive strategies of the virus. With the overall aim of designing a broad coverage vaccine that induces an effective CTL response aga...... will be available for IVIS. This study exemplifies how bioinformatics epitope prediction, recombinant SLA molecules and RNA virus replicon design can be used to engineer a replicating non-propagating vaccine tailored to deliver conserved and immunogenic CTL epitopes....... against PRRSV, we have used a bioinformatics approach to identify common PRRSV type 2 epitopes predicted to react broadly with predominant swine MHC (SLA) alleles. All possible 9- and 10-mer peptides derived from 104 wild-type strains were analyzed in silico for their predicted binding affinity to 3...... cloned into a classical swine fever virus (CSFV)-derived replicon vector. Virus replicon particles (VRP) were rescued by transfection of a complementing cell line with replicon RNA. Polyepitope expression and subsequent proteasomal degradation was confirmed indirectly by increased FLAG-tagged protein...

  12. [Research advances in secondary development of Chinese patent medicines based on quality by design concept].

    Science.gov (United States)

    Gong, Xing-Chu; Chen, Teng; Qu, Hai-Bin

    2017-03-01

    Quality by design (QbD) concept is an advanced pharmaceutical quality control concept. The application of QbD concept in the research and development of pharmaceutical processes of traditional Chinese medicines (TCM) mainly contains five parts, including the definition of critical processes and their evaluation criteria, the determination of critical process parameters and critical material attributes, the establishment of quantitative models, the development of design space, as well as the application and continuous improvement of control strategy. In this work, recent research advances in QbD concept implementation methods in the secondary development of Chinese patent medicines were reviewed, and five promising fields of the implementation of QbD concept were pointed out, including the research and development of TCM new drugs and Chinese medicine granules for formulation, modeling of pharmaceutical processes, development of control strategy based on industrial big data, strengthening the research of process amplification rules, and the development of new pharmaceutical equipment.. Copyright© by the Chinese Pharmaceutical Association.

  13. Waste-to-energy advanced cycles and new design concepts for efficient power plants

    CERN Document Server

    Branchini, Lisa

    2015-01-01

    This book provides an overview of state-of-the-art technologies for energy conversion from waste, as well as a much-needed guide to new and advanced strategies to increase Waste-to-Energy (WTE) plant efficiency. Beginning with an overview of municipal solid waste production and disposal, basic concepts related to Waste-To-Energy conversion processes are described, highlighting the most relevant aspects impacting the thermodynamic efficiency of WTE power plants. The pervasive influences of main steam cycle parameters and plant configurations on WTE efficiency are detailed and quantified. Advanc

  14. Advanced transportation system study: Manned launch vehicle concepts for two way transportation system payloads to LEO

    Science.gov (United States)

    Duffy, James B.

    1993-01-01

    The purpose of the Advanced Transportation System Study (ATSS) task area 1 study effort is to examine manned launch vehicle booster concepts and two-way cargo transfer and return vehicle concepts to determine which of the many proposed concepts best meets NASA's needs for two-way transportation to low earth orbit. The study identified specific configurations of the normally unmanned, expendable launch vehicles (such as the National Launch System family) necessary to fly manned payloads. These launch vehicle configurations were then analyzed to determine the integrated booster/spacecraft performance, operations, reliability, and cost characteristics for the payload delivery and return mission. Design impacts to the expendable launch vehicles which would be required to perform the manned payload delivery mission were also identified. These impacts included the implications of applying NASA's man-rating requirements, as well as any mission or payload unique impacts. The booster concepts evaluated included the National Launch System (NLS) family of expendable vehicles and several variations of the NLS reference configurations to deliver larger manned payload concepts (such as the crew logistics vehicle (CLV) proposed by NASA JSC). Advanced, clean sheet concepts such as an F-1A engine derived liquid rocket booster (LRB), the single stage to orbit rocket, and a NASP-derived aerospace plane were also included in the study effort. Existing expendable launch vehicles such as the Titan 4, Ariane 5, Energia, and Proton were also examined. Although several manned payload concepts were considered in the analyses, the reference manned payload was the NASA Langley Research Center's HL-20 version of the personnel launch system (PLS). A scaled up version of the PLS for combined crew/cargo delivery capability, the HL-42 configuration, was also included in the analyses of cargo transfer and return vehicle (CTRV) booster concepts. In addition to strictly manned payloads, two-way cargo

  15. THE EFFECTIVENESS OF CTL MODEL GUIDED INQUIRI-BASED IN THE TOPIC OF CHEMICALS IN DAILY LIFE TO IMPROVE STUDENTS’ LEARNING OUTCOMES AND ACTIVENESS

    OpenAIRE

    N. R. Fitriani; A. Widiyatmoko; M. Khusniati

    2016-01-01

    Science learning in school can be applied by connecting the material in the learning with real life. However in fact science learning process in SMP Negeri 10 Magelang has not emphasized students’ activity to relate science to real life. Learning science using CTL guided inquiry-based model implement the learning in where teacher provides initial questions related issues or events in everyday life, then students do experiments to prove concepts of science guided by teacher.The purpose of this...

  16. Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

    Directory of Open Access Journals (Sweden)

    Xihui "Paul" Zhang

    2015-06-01

    Full Text Available Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We present a classic brain teaser that is used to communicate and demonstrate advanced software development concepts and techniques. Our results show that students with varied academic experiences and goals, assuming at least one procedural/structured programming pre-requisite, can benefit from and also be challenged by such an exercise. Although this problem has been used by others in the classroom, we believe that our use of this problem in imparting such a broad range of topics to a diverse student population is unique.

  17. Concepts for a slow-positron target at the advanced photon source

    International Nuclear Information System (INIS)

    Lessner, E.; White, M.

    1997-01-01

    The Advanced Photon Source (APS) linear accelerator beam could be used to produce slow positrons during the hours between the storage ring injection cycles. Initial concepts for the design of a target that is optimized for slow-positron production are discussed, and simulation results are presented. Some possible ways to increase the nominal linac beam power for improved slow-positron production are also discussed

  18. Study of advanced composite structural design concepts for an arrow wing supersonic cruise configuration, task 3

    Science.gov (United States)

    1978-01-01

    A structural design study was conducted to assess the relative merits of structural concepts using advanced composite materials for an advanced supersonic aircraft cruising at Mach 2.7. The configuration and structural arrangement developed during Task I and II of the study, was used as the baseline configuration. Allowable stresses and strains were established for boron and advanced graphite fibers based on projected fiber properties available in the next decade. Structural concepts were designed and analyzed using graphite polyimide and boron polyimide, applied to stiffened panels and conventional sandwich panels. The conventional sandwich panels were selected as the structural concept to be used on the wing structure. The upper and lower surface panels of the Task I arrow wing were redesigned using high-strength graphite polyimide sandwich panels over the titanium spars and ribs. The ATLAS computer system was used as the basis for stress analysis and resizing the surface panels using the loads from the Task II study, without adjustment for change in aeroelastic deformation. The flutter analysis indicated a decrease in the flutter speed compared to the baseline titanium wing design. The flutter analysis indicated a decrease in the flutter speed compared to the baseline titanium wing design. The flutter speed was increased to that of the titanium wing, with a weight penalty less than that of the metallic airplane.

  19. NASA Advanced Concepts Office, Earth-To-Orbit Team Design Process and Tools

    Science.gov (United States)

    Waters, Eric D.; Garcia, Jessica; Threet, Grady E., Jr.; Phillips, Alan

    2013-01-01

    The Earth-to-Orbit Team (ETO) of the Advanced Concepts Office (ACO) at NASA Marshall Space Flight Center (MSFC) is considered the pre-eminent "go-to" group for pre-phase A and phase A concept definition. Over the past several years the ETO team has evaluated thousands of launch vehicle concept variations for a significant number of studies including agency-wide efforts such as the Exploration Systems Architecture Study (ESAS), Constellation, Heavy Lift Launch Vehicle (HLLV), Augustine Report, Heavy Lift Propulsion Technology (HLPT), Human Exploration Framework Team (HEFT), and Space Launch System (SLS). The ACO ETO Team is called upon to address many needs in NASA's design community; some of these are defining extremely large trade-spaces, evaluating advanced technology concepts which have not been addressed by a large majority of the aerospace community, and the rapid turn-around of highly time critical actions. It is the time critical actions, those often limited by schedule or little advanced warning, that have forced the five member ETO team to develop a design process robust enough to handle their current output level in order to meet their customer's needs. Based on the number of vehicle concepts evaluated over the past year this output level averages to four completed vehicle concepts per day. Each of these completed vehicle concepts includes a full mass breakdown of the vehicle to a tertiary level of subsystem components and a vehicle trajectory analysis to determine optimized payload delivery to specified orbital parameters, flight environments, and delta v capability. A structural analysis of the vehicle to determine flight loads based on the trajectory output, material properties, and geometry of the concept is also performed. Due to working in this fast-paced and sometimes rapidly changing environment, the ETO Team has developed a finely tuned process to maximize their delivery capabilities. The objective of this paper is to describe the interfaces

  20. Prestressed-concrete pressure vessels and their applicability to advanced-energy-system concepts

    International Nuclear Information System (INIS)

    Naus, D.J.

    1983-01-01

    Prestressed concrete pressure vessels (PCPVs) are, in essence, spaced steel structures since their strength is derived from a multitude of steel elements made up of deformed reinforcing bars and prestressing tendons which are present in sufficient quantities to carry tension loads imposed on the vessel. Other major components of a PCPV include the concrete, liner and cooling system, and insulation. PCPVs exhibit a number of advantages which make them ideally suited for application to advanced energy concepts: fabricability in virtually any size and shape using available technology, improved safety, reduced capital costs, and a history of proven performance. PCPVs have many applications to both nuclear- and non-nuclear-based energy systems concepts. Several of these concepts will be discussed as well as the research and development activities conducted at ORNL in support of PCPV development

  1. CATHENA Analysis Of Candu Advanced Passive Moderator Concept In Normal Operation Condition

    International Nuclear Information System (INIS)

    Alfa, Sudjatmi K

    2001-01-01

    In the CANDU - advanced passive moderator (APM) concept, the positive void reactivity is eliminated by reducing the density of the moderator. The simple model for the CANDU APM concept consists of the calandria, heat exchanger, pump, and a stabilizing tank, along with connecting piping. The calandria is divided into two parts, one part simulates the down area, while the other simulates up flow area. To demonstrate the thermalhydraulic behavior of the APM concept, Canadian algorithm for thermalhydraulic network analysis (CATHENA) code is used. The simulation for a pressure boundary condition of 300, 330 and 360 kPa and for water coolant mass flow rate boundary conditions of 2000 and 3000 kg/s respectively have been studied. Preliminary results show that there is boiling in the core, with vapor condensing in the heat exchanger. It is important to note, that the solution had not reached steady state when the boiling occurred

  2. Design Concept of Advanced Sodium-Cooled Fast Reactor and Related R&D in Korea

    Directory of Open Access Journals (Sweden)

    Yeong-il Kim

    2013-01-01

    Full Text Available Korea imports about 97% of its energy resources due to a lack of available energy resources. In this status, the role of nuclear power in electricity generation is expected to become more important in future years. In particular, a fast reactor system is one of the most promising reactor types for electricity generation, because it can utilize efficiently uranium resources and reduce radioactive waste. Acknowledging the importance of a fast reactor in a future energy policy, the long-term advanced SFR development plan was authorized by KAEC in 2008 and updated in 2011 which will be carried out toward the construction of an advanced SFR prototype plant by 2028. Based upon the experiences gained during the development of the conceptual designs for KALIMER, KAERI recently developed advanced sodium-cooled fast reactor (SFR design concepts of TRU burner that can better meet the generation IV technology goals. The current status of nuclear power and SFR design technology development program in Korea will be discussed. The developments of design concepts including core, fuel, fluid system, mechanical structure, and safety evaluation have been performed. In addition, the advanced SFR technologies necessary for its commercialization and the basic key technologies have been developed including a large-scale sodium thermal-hydraulic test facility, super-critical Brayton cycle system, under-sodium viewing techniques, metal fuel development, and developments of codes, and validations are described as R&D activities.

  3. Strategi Bisnis pada PT CTL Dengan Pendekatan Metode Tows

    Directory of Open Access Journals (Sweden)

    Tjia Fie Tjoe

    2010-11-01

    Full Text Available The purpose of this research is determining direction of the correct business strategy to be applied by PT CTL, a garment company producing cloth for men. Research method used by the author is descriptive analysis with a case study research method. Research is conducted by collecting data obtained through survey by interview and giving questionnaire to all staff and head and also observation by evaluating directly the research object and also through literature study. Data analysis is conducted through input phase by using IFAS and EFAS matrix, adaptation phase with TOWS diagram, TOWS matrix and Internal-External matrix, and also uses SPACE matrix and also BCG matrix to analyse company's finance situation. Based on the conducted analysist the recommended corporation level strategy to be used by the company is diversification strategy direct to growth and stability. 

  4. Advanced concepts under development in the United States Breeder-Fuel-Reprocessing Program

    International Nuclear Information System (INIS)

    Burch, W.D.

    1981-01-01

    Advanced concepts and techniques for the fuel reprocessing step are being developed. These concepts have been incorporated into the conceptual design of a Hot Experimental Facility (HEF), which is intended to demonstrate reprocessing of the first US breeder demonstration reactor. To achieve system reliability and reduce occupational doses, a concept of totally remote operation and maintenance (termed Remotex) has been conceived and is being developed. In this concept, maintenance and mechanical operations are accomplished with remotely operated bilateral force-reflecting electronic master/slave manipulators. Suitable transport systems, coupled with remote closed-circuit television viewing, are provided to extend man's capabilities into the hostile cell environment. New equipment concepts are being developed for the fuel dismantling and shearing step, a high-temperature dry process termed voloxidation to remove tritium, a continuous rotary dissolver, and for an improved centrifugal solvent contractor. Techniques have been developed, using engineering-scale equipment with active tracers for retention of 85 Kr, radioiodine, 14 C, and 3 H

  5. US long distance fiber optic networks: Technology, evolution and advanced concepts. Volume 3: Advanced networks and economics

    Science.gov (United States)

    1986-10-01

    This study projects until 2000 the evolution of long distance fiber optic networks in the U.S. Volume 1 is the executive Summary. Volume 2 focuses on fiber optic components and systems that are directly related to the operation of long-haul networks. Optimistic, pessimistic and most likely scenarios of technology development are presented. The activities of national and regional companies implementing fiber long haul networks are also highlighted, along with an analysis of the market and regulatory forces affecting network evolution. Volume 3 presents advanced fiber optic network concept definitions. Inter-LATA traffic is quantified and forms the basis for the construction of 11-, 15-, 17-, and 23-node networks. Using the technology projections from Volume 2, a financial model identifies cost drivers and determines circuit mile costs between any two LATAs. A comparison of fiber optics with alternative transmission concludes the report.

  6. To MARS and Beyond with Nuclear Power - Design Concept of Korea Advanced Nuclear Thermal Engine Rocket

    International Nuclear Information System (INIS)

    Nam, Seung Hyun; Chang, Soon Heung

    2013-01-01

    The President Park of ROK has also expressed support for space program promotion, praising the success of NARO as evidence of a positive outlook. These events hint a strong signal that ROK's space program will be accelerated by the national eager desire. In this national eager desire for space program, the policymakers and the aerospace engineers need to pay attention to the advanced nuclear technology of ROK that is set to a major world nuclear energy country, even exporting the technology. The space nuclear application is a very much attractive option because its energy density is the most enormous among available energy sources in space. This paper presents the design concept of Korea Advanced Nuclear Thermal Engine Rocket (KANuTER) that is one of the advanced nuclear thermal rocket engine developing in Korea Advanced Institute of Science and Technology (KAIST) for space application. Solar system exploration relying on CRs suffers from long trip time and high cost. In this regard, nuclear propulsion is a very attractive option for that because of higher performance and already demonstrated technology. Although ROK was a late entrant into elite global space club, its prospect as a space racer is very bright because of the national eager desire and its advanced technology. Especially it is greatly meaningful that ROK has potential capability to launch its nuclear technology into space as a global nuclear energy leader and a soaring space adventurer. In this regard, KANuTER will be a kind of bridgehead for Korean space nuclear application

  7. The Los Alamos Laser Acceleration of Particles Workshop and beginning of the advanced accelerator concepts field

    Science.gov (United States)

    Joshi, C.

    2012-12-01

    The first Advanced Acceleration of Particles-AAC-Workshop (actually named Laser Acceleration of Particles Workshop) was held at Los Alamos in January 1982. The workshop lasted a week and divided all the acceleration techniques into four categories: near field, far field, media, and vacuum. Basic theorems of particle acceleration were postulated (later proven) and specific experiments based on the four categories were formulated. This landmark workshop led to the formation of the advanced accelerator R&D program in the HEP office of the DOE that supports advanced accelerator research to this day. Two major new user facilities at Argonne and Brookhaven and several more directed experimental efforts were built to explore the advanced particle acceleration schemes. It is not an exaggeration to say that the intellectual breadth and excitement provided by the many groups who entered this new field provided the needed vitality to then recently formed APS Division of Beams and the new online journal Physical Review Special Topics-Accelerators and Beams. On this 30th anniversary of the AAC Workshops, it is worthwhile to look back at the legacy of the first Workshop at Los Alamos and the fine groundwork it laid for the field of advanced accelerator concepts that continues to flourish to this day.

  8. To MARS and Beyond with Nuclear Power - Design Concept of Korea Advanced Nuclear Thermal Engine Rocket

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Seung Hyun; Chang, Soon Heung [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2013-05-15

    The President Park of ROK has also expressed support for space program promotion, praising the success of NARO as evidence of a positive outlook. These events hint a strong signal that ROK's space program will be accelerated by the national eager desire. In this national eager desire for space program, the policymakers and the aerospace engineers need to pay attention to the advanced nuclear technology of ROK that is set to a major world nuclear energy country, even exporting the technology. The space nuclear application is a very much attractive option because its energy density is the most enormous among available energy sources in space. This paper presents the design concept of Korea Advanced Nuclear Thermal Engine Rocket (KANuTER) that is one of the advanced nuclear thermal rocket engine developing in Korea Advanced Institute of Science and Technology (KAIST) for space application. Solar system exploration relying on CRs suffers from long trip time and high cost. In this regard, nuclear propulsion is a very attractive option for that because of higher performance and already demonstrated technology. Although ROK was a late entrant into elite global space club, its prospect as a space racer is very bright because of the national eager desire and its advanced technology. Especially it is greatly meaningful that ROK has potential capability to launch its nuclear technology into space as a global nuclear energy leader and a soaring space adventurer. In this regard, KANuTER will be a kind of bridgehead for Korean space nuclear application.

  9. Study of advanced composite structural design concepts for an arrow wing supersonic cruise configuration

    Science.gov (United States)

    Turner, M. J.; Grande, D. L.

    1978-01-01

    Based on estimated graphite and boron fiber properties, allowable stresses and strains were established for advanced composite materials. Stiffened panel and conventional sandwich panel concepts were designed and analyzed, using graphite/polyimide and boron/polyimide materials. The conventional sandwich panel was elected as the structural concept for the modified wing structure. Upper and lower surface panels of the arrow wing structure were then redesigned, using high strength graphite/polyimide sandwich panels, retaining the titanium spars and ribs from the prior study. The ATLAS integrated analysis and design system was used for stress analysis and automated resizing of surface panels. Flutter analysis of the hybrid structure showed a significant decrease in flutter speed relative to the titanium wing design. The flutter speed was increased to that of the titanium design by selective increase in laminate thickness and by using graphite fibers with properties intermediate between high strength and high modulus values.

  10. Work Domain Analysis Methodology for Development of Operational Concepts for Advanced Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Hugo, Jacques [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-05-01

    This report describes a methodology to conduct a Work Domain Analysis in preparation for the development of operational concepts for new plants. This method has been adapted from the classical method described in the literature in order to better deal with the uncertainty and incomplete information typical of first-of-a-kind designs. The report outlines the strategy for undertaking a Work Domain Analysis of a new nuclear power plant and the methods to be used in the development of the various phases of the analysis. Basic principles are described to the extent necessary to explain why and how the classical method was adapted to make it suitable as a tool for the preparation of operational concepts for a new nuclear power plant. Practical examples are provided of the systematic application of the method and the various presentation formats in the operational analysis of advanced reactors.

  11. BALANCED SCORECARD AS AN ADVANCED MANAGEMENT CONCEPT WITHIN THE INTEGRATED QUALITY MANAGEMENT MODEL

    Directory of Open Access Journals (Sweden)

    Stevan Zivojinovic

    2008-03-01

    Full Text Available The significance of >Integratedquality management< (IQM model, originating form St.Gallen-model, is reflected in the need for synergic application of new and advanced concepts of management theory and practise. Balanced score card (BSC within IQM model becomes a catalyst of business success for a modern organization by focusing on organizational variables-business strategy, organization structure and corporate culture. BSC is the leading system of performance tracking and strategy implementation, consistent with other management concepts and methods for managing process improvement. Through BSC, IQM processes' activities correlate with organization business results. BSC management processes enable integration of all decision-making levels, from institutional via strategic to operative, in the process starting from planing, i.e. formulating and implementation of strategy, to feed back by performance measurement and control.

  12. DEVELOPMENT OF OPERATIONAL CONCEPTS FOR ADVANCED SMRs: THE ROLE OF COGNITIVE SYSTEMS ENGINEERING

    Energy Technology Data Exchange (ETDEWEB)

    Jacques Hugo; David Gertman

    2014-04-01

    Advanced small modular reactors (AdvSMRs) will use advanced digital instrumentation and control systems, and make greater use of automation. These advances not only pose technical and operational challenges, but will inevitably have an effect on the operating and maintenance (O&M) cost of new plants. However, there is much uncertainty about the impact of AdvSMR designs on operational and human factors considerations, such as workload, situation awareness, human reliability, staffing levels, and the appropriate allocation of functions between the crew and various automated plant systems. Existing human factors and systems engineering design standards and methodologies are not current in terms of human interaction requirements for dynamic automated systems and are no longer suitable for the analysis of evolving operational concepts. New models and guidance for operational concepts for complex socio-technical systems need to adopt a state-of-the-art approach such as Cognitive Systems Engineering (CSE) that gives due consideration to the role of personnel. This approach we report on helps to identify and evaluate human challenges related to non-traditional concepts of operations. A framework - defining operational strategies was developed based on the operational analysis of Argonne National Laboratory’s Experimental Breeder Reactor-II (EBR-II), a small (20MWe) sodium-cooled reactor that was successfully operated for thirty years. Insights from the application of the systematic application of the methodology and its utility are reviewed and arguments for the formal adoption of CSE as a value-added part of the Systems Engineering process are presented.

  13. Development of Advanced Concept for Shortening Construction Period of ABWR Plant

    International Nuclear Information System (INIS)

    Hiroshi Ijichi; Toshio Yamashita; Masahiro Tsutagawa; Hiroya Mori; Nobuaki Ooshima; Jun Miura; Minoru Kanechika; Nobuaki Miura

    2002-01-01

    Construction of a nuclear power plant (NPP) requires a very long period because of large amount of construction materials and many issues for negotiation among multiple sections. Shortening the construction period advances the date of return on an investment, and can also result in reduced construction cost. Therefore, the study of this subject has a very high priority for utilities. We achieved a construction period of 37 months from the first concrete work to fuel loading (F/L) (51.5 months from the inspection of the foundation (I/F) to the start of commercial operation (C/O)) at the Kashiwazaki-Kariwa NPPs No. 6 and 7 (KK-6/7), which are the first ABWR plants in the world. At TEPCO's next plant, we think that a construction period of less than 36 months (45 months from I/F to C/O) can be realized based on conventional methods such as early start of equipment installation and blocking of equipment to be brought in advance. Furthermore, we are studying the feasibility of a 21.5-month construction period (30 months from I/F to C/O) with advanced ideas and methods. The important concepts for a 21.5-month construction period are adoption of a new building structure that is the steel plate reinforced concrete (SC) structure and promotion of extensive modularization of equipment and building structure. With introducing these new concepts, we are planning the master schedule (M/S) and finding solutions to conflicts in the schedule of area release from building construction work to equipment installation work (schedule-conflicts.) In this report, we present the shortest construction period and an effective method to put it into practice for the conventional general arrangement (GA) of ABWR. In the future, we will continue the study on the improvement of building configuration and arrangements, and make clear of the concept for large composite modules of building structures and equipment. (authors)

  14. Feasibility of a Networked Air Traffic Infrastructure Validation Environment for Advanced NextGen Concepts

    Science.gov (United States)

    McCormack, Michael J.; Gibson, Alec K.; Dennis, Noah E.; Underwood, Matthew C.; Miller,Lana B.; Ballin, Mark G.

    2013-01-01

    Abstract-Next Generation Air Transportation System (NextGen) applications reliant upon aircraft data links such as Automatic Dependent Surveillance-Broadcast (ADS-B) offer a sweeping modernization of the National Airspace System (NAS), but the aviation stakeholder community has not yet established a positive business case for equipage and message content standards remain in flux. It is necessary to transition promising Air Traffic Management (ATM) Concepts of Operations (ConOps) from simulation environments to full-scale flight tests in order to validate user benefits and solidify message standards. However, flight tests are prohibitively expensive and message standards for Commercial-off-the-Shelf (COTS) systems cannot support many advanced ConOps. It is therefore proposed to simulate future aircraft surveillance and communications equipage and employ an existing commercial data link to exchange data during dedicated flight tests. This capability, referred to as the Networked Air Traffic Infrastructure Validation Environment (NATIVE), would emulate aircraft data links such as ADS-B using in-flight Internet and easily-installed test equipment. By utilizing low-cost equipment that is easy to install and certify for testing, advanced ATM ConOps can be validated, message content standards can be solidified, and new standards can be established through full-scale flight trials without necessary or expensive equipage or extensive flight test preparation. This paper presents results of a feasibility study of the NATIVE concept. To determine requirements, six NATIVE design configurations were developed for two NASA ConOps that rely on ADS-B. The performance characteristics of three existing in-flight Internet services were investigated to determine whether performance is adequate to support the concept. Next, a study of requisite hardware and software was conducted to examine whether and how the NATIVE concept might be realized. Finally, to determine a business case

  15. Advanced Hybrid Spacesuit Concept Featuring Integrated Open Loop and Closed Loop Ventilation Systems

    Science.gov (United States)

    Daniel, Brian A.; Fitzpatrick, Garret R.; Gohmert, Dustin M.; Ybarra, Rick M.; Dub, Mark O.

    2013-01-01

    A document discusses the design and prototype of an advanced spacesuit concept that integrates the capability to function seamlessly with multiple ventilation system approaches. Traditionally, spacesuits are designed to operate both dependently and independently of a host vehicle environment control and life support system (ECLSS). Spacesuits that operate independent of vehicle-provided ECLSS services must do so with equipment selfcontained within or on the spacesuit. Suits that are dependent on vehicle-provided consumables must remain physically connected to and integrated with the vehicle to operate properly. This innovation is the design and prototype of a hybrid spacesuit approach that configures the spacesuit to seamlessly interface and integrate with either type of vehicular systems, while still maintaining the ability to function completely independent of the vehicle. An existing Advanced Crew Escape Suit (ACES) was utilized as the platform from which to develop the innovation. The ACES was retrofitted with selected components and one-off items to achieve the objective. The ventilation system concept was developed and prototyped/retrofitted to an existing ACES. Components were selected to provide suit connectors, hoses/umbilicals, internal breathing system ducting/ conduits, etc. The concept utilizes a lowpressure- drop, high-flow ventilation system that serves as a conduit from the vehicle supply into the suit, up through a neck seal, into the breathing helmet cavity, back down through the neck seal, out of the suit, and returned to the vehicle. The concept also utilizes a modified demand-based breathing system configured to function seamlessly with the low-pressure-drop closed-loop ventilation system.

  16. Advanced direct liquefaction concepts for PETC generic units. Final report, Phase I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    The Advanced Concepts for Direct Coal Liquefaction program was initiated by the Department of Energy in 1991 to develop technologies that could significantly reduce the cost of producing liquid fuels by the direct liquefaction of coal. The advanced 2-stage liquefaction technology that was developed at Wilsonville over the past 10 years has contributed significantly toward decreasing the cost of producing liquids from coal to about $33/bbl. It remains, however, the objective of DOE to further reduce this cost to a level more competitive with petroleum based products. This project, among others, was initiated to investigate various alternative approaches to develop technologies that might ultimately lead to a 25 % reduction in cost of product. In this project a number of novel concepts were investigated, either individually or in a coupled configuration that had the potential to contribute toward meeting the DOE goal. The concepts included mature technologies or ones closely related to them, such as coal cleaning by oil agglomeration, fluid coking and distillate hydrotreating and dewaxing. Other approaches that were either embryonic or less developed were chemical pretreatment of coal to remove oxygen, and dispersed catalyst development for application in the 2-stage liquefaction process. This report presents the results of this project. It is arranged in four sections which were prepared by participating organizations responsible for that phase of the project. A summary of the overall project and the principal results are given in this section. First, however, an overview of the process economics and the process concepts that were developed during the course of this program is presented.

  17. Advance directives in english and French law: different concepts, different values, different societies.

    Science.gov (United States)

    Horn, Ruth Judith

    2014-03-01

    In Western societies advance directives are widely recognised as important means to extend patient self-determination under circumstances of incapacity. Following other countries, England and France have adopted legislation aiming to clarify the legal status of advance directives. In this paper, I will explore similarities and differences in both sets of legislation, the arguments employed in the respective debates and the socio-political structures on which these differences are based. The comparison highlights how different legislations express different concepts emphasising different values accorded to the duty to respect autonomy and to protect life, and how these differences are informed by different socio-political contexts. Furthermore each country associates different ethical concerns with ADs which raise doubts about whether these directives are a theoretical idea which is hardly applicable in practice.

  18. Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations

    Energy Technology Data Exchange (ETDEWEB)

    Hugo, Jacques [Idaho National Lab. (INL), Idaho Falls, ID (United States); Forester, John [Idaho National Lab. (INL), Idaho Falls, ID (United States); Gertman, David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Joe, Jeffrey [Idaho National Lab. (INL), Idaho Falls, ID (United States); Medema, Heather [Idaho National Lab. (INL), Idaho Falls, ID (United States); Persensky, Julius [Idaho National Lab. (INL), Idaho Falls, ID (United States); Whaley, April [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2013-08-01

    This report presents preliminary research results from the investigation into the development of new models and guidance for Concepts of Operations in advanced small modular reactor (AdvSMR) designs. AdvSMRs are nuclear power plants (NPPs), but unlike conventional large NPPs that are constructed on site, AdvSMRs systems and components will be fabricated in a factory and then assembled on site. AdvSMRs will also use advanced digital instrumentation and control systems, and make greater use of automation. Some AdvSMR designs also propose to be operated in a multi-unit configuration with a single central control room as a way to be more cost-competitive with existing NPPs. These differences from conventional NPPs not only pose technical and operational challenges, but they will undoubtedly also have regulatory compliance implications, especially with respect to staffing requirements and safety standards.

  19. Advanced concepts for waste management and nuclear energy production in the EURATOM 5. framework programme

    International Nuclear Information System (INIS)

    Hugon, M.; Bhatnagar, V.P.; Martin Bermejon, J.

    2002-01-01

    This paper summarises the objectives of the research projects on partitioning and transmutation (P and T) of long-lived radionuclides in nuclear waste and advanced systems for nuclear energy production in the key action on nuclear fission of the EURATOM 5. Framework Programme (FP5) (1998-2002). As these FP5 projects cover the main aspects of P and T, they should provide a basis for evaluating the practicability, on an industrial scale, of P and T for reducing the amount of long-lived radionuclides to be disposed of. Concerning advanced concepts, a cluster of projects is addressing the key technical issues to be solved before implementing high-temperature reactors (HTRs) commercially for energy production. Finally, the European Commissions proposal fora New Framework Programme (2002-2006) is briefly outlined. (authors)

  20. Advanced concepts for waste management and nuclear energy production in the EURATOM fifth framework programme

    International Nuclear Information System (INIS)

    Hugon, M.; Bhatnagar, V.P.; Martin Bermejo, J.

    2001-01-01

    This paper summarises the objectives of the research projects on Partitioning and Transmutation (P and T) of long lived radionuclides in nuclear waste and advanced systems for nuclear energy production in the key action on nuclear fission of the EURATOM Fifth Framework Programme (FP5) (1998-2002). As these FP5 projects cover the main aspects of P and T, they should provide a basis for evaluating the practicability, on an industrial scale, of P and T for reducing the amount of long lived radionuclides to be disposed of. Concerning advanced concepts, a cluster of projects is addressing the key technical issues to be solved before implementing High Temperature Reactors (HTRs) commercially for energy production. Finally, the European Commission(tm)s proposal for a New Framework Programme (2002-2006) is briefly outlined. (author)

  1. Advanced Supersonic Nozzle Concepts: Experimental Flow Visualization Results Paired With LES

    Science.gov (United States)

    Berry, Matthew; Magstadt, Andrew; Stack, Cory; Gaitonde, Datta; Glauser, Mark; Syracuse University Team; The Ohio State University Team

    2015-11-01

    Advanced supersonic nozzle concepts are currently under investigation, utilizing multiple bypass streams and airframe integration to bolster performance and efficiency. This work focuses on the parametric study of a supersonic, multi-stream jet with aft deck. The single plane of symmetry, rectangular nozzle, displays very complex and unique flow characteristics. Flow visualization techniques in the form of PIV and schlieren capture flow features at various deck lengths and Mach numbers. LES is compared to the experimental results to both validate the computational model and identify limitations of the simulation. By comparing experimental results to LES, this study will help create a foundation of knowledge for advanced nozzle designs in future aircraft. SBIR Phase II with Spectral Energies, LLC under direction of Barry Kiel.

  2. Inherent safe design of advanced high temperature reactors - concepts for future nuclear power plants

    International Nuclear Information System (INIS)

    Hodzic, A.; Kugeler, K.

    1997-01-01

    This paper discusses the applicable solutions for a commercial size High Temperature Reactor (HTR) with inherent safety features. It describes the possible realization using an advanced concept which combines newly proposed design characteristics with some well known and proven HTR inherent safety features. The use of the HTR technology offers the conceivably best solution to meet the legal criteria, recently stated in Germany, for the future reactor generation. Both systems, block and pebble bed ,reactor, could be under certain design conditions self regulating in terms of core nuclear heat, mechanical stability and the environmental transfer. 23 refs., 7 figs

  3. Concept design and cluster control of advanced space connectable intelligent microsatellite

    Science.gov (United States)

    Wang, Xiaohui; Li, Shuang; She, Yuchen

    2017-12-01

    In this note, a new type of advanced space connectable intelligent microsatellite is presented to extend the range of potential application of microsatellite and improve the efficiency of cooperation. First, the overall concept of the micro satellite cluster is described, which is characterized by autonomously connecting with each other and being able to realize relative rotation through the external interfaces. Second, the multi-satellite autonomous assembly algorithm and control algorithm of the cluster motion are developed to make the cluster system combine into a variety of configurations in order to achieve different types of functionality. Finally, the design of the satellite cluster system is proposed, and the possible applications are discussed.

  4. The conception of disability and mental illness in advanced welfare states

    DEFF Research Database (Denmark)

    Ringø, Pia; Høgsbro, Kjeld

    2017-01-01

    The chapter presents historical developments in the conception of disability and services for people with disability and mental illness. It identifies the social, political and technological movements, which have led to the epistemologies that exist in this field today. The diverse understandings...... of mental problems and vulnerability have all through history motivated different guidelines for social work practice when it comes to people with cognitive and mental deficits and in the final section of the chapter, we discuss how current sociological, neurological, and psychiatric perspectives...... in research as well as clinical experiences from advanced welfare services might support a new model for understanding mental vulnerability....

  5. Advanced automation concepts applied to Experimental Breeder Reactor-II startup

    International Nuclear Information System (INIS)

    Berkan, R.C.; Upadhyaya, B.R.; Bywater, R.L.

    1991-08-01

    The major objective of this work is to demonstrate through simulations that advanced liquid-metal reactor plants can be operated from low power by computer control. Development of an automatic control system with this objective will help resolve specific issues and provide proof through demonstration that automatic control for plant startup is feasible. This paper presents an advanced control system design for startup of the Experimental Breeder Reactor-2 (EBR-2) located at Idaho Falls, Idaho. The design incorporates recent methods in nonlinear control with advanced diagnostics techniques such as neural networks to form an integrated architecture. The preliminary evaluations are obtained in a simulated environment by a low-order, valid nonlinear model. Within the framework of phase 1 research, the design includes an inverse dynamics controller, a fuzzy controller, and an artificial neural network controller. These three nonlinear control modules are designed to follow the EBR-2 startup trajectories in a multi-input/output regime. They are coordinated by a supervisory routine to yield a fault-tolerant, parallel operation. The control system operates in three modes: manual, semiautomatic, and fully automatic control. The simulation results of the EBR-2 startup transients proved the effectiveness of the advanced concepts. The work presented in this paper is a preliminary feasibility analysis and does not constitute a final design of an automated startup control system for EBR-2. 14 refs., 43 figs

  6. The Effects of Using Concept Mapping for Improving Advanced Level Biology Students' Lower- and Higher-Order Cognitive Skills

    Science.gov (United States)

    Bramwell-Lalor, Sharon; Rainford, Marcia

    2014-01-01

    This paper reports on teachers' use of concept mapping as an alternative assessment strategy in advanced level biology classes and its effects on students' cognitive skills on selected biology concepts. Using a mixed methods approach, the study employed a pre-test/post-test quasi-experimental design involving 156 students and 8 teachers from…

  7. Core Thermal-Hydraulic Conceptual Design for the Advanced SFR Design Concepts

    International Nuclear Information System (INIS)

    Cho, Chung Ho; Chang, Jin Wook; Yoo, Jae Woon; Song, Hoon; Choi, Sun Rock; Park, Won Seok; Kim, Sang Ji

    2010-01-01

    The Korea Atomic Energy Research Institute (KAERI) has developed the advanced SFR design concepts from 2007 to 2009 under the National longterm Nuclear R and D Program. Two types of core designs, 1,200 MWe breakeven and 600 MWe TRU burner core have been proposed and evaluated whether they meet the design requirements for the Gen IV technology goals of sustainability, safety and reliability, economics, proliferation resistance, and physical protection. In generally, the core thermal hydraulic design is performed during the conceptual design phase to efficiently extract the core thermal power by distributing the appropriate sodium coolant flow according to the power of each assembly because the conventional SFR core is composed of hundreds of ducted assemblies with hundreds of fuel rods. In carrying out the thermal and hydraulic design, special attention has to be paid to several performance parameters in order to assure proper performance and safety of fuel and core; the coolant boiling, fuel melting, structural integrity of the components, fuel-cladding eutectic melting, etc. The overall conceptual design procedure for core thermal and hydraulic conceptual design, i.e., flow grouping and peak pin temperature calculations, pressure drop calculations, steady-state and detailed sub-channel analysis is shown Figure 1. In the conceptual design phase, results of core thermal-hydraulic design for advanced design concepts, the core flow grouping, peak pin cladding mid-wall temperature, and pressure drop calculations, are summarized in this study

  8. Advanced Transportation System Studies. Technical Area 3: Alternate Propulsion Subsystem Concepts. Volume 1; Executive Summary

    Science.gov (United States)

    Levack, Daniel J. H.

    2000-01-01

    The Alternate Propulsion Subsystem Concepts contract had seven tasks defined that are reported under this contract deliverable. The tasks were: FAA Restart Study, J-2S Restart Study, Propulsion Database Development. SSME Upper Stage Use. CERs for Liquid Propellant Rocket Engines. Advanced Low Cost Engines, and Tripropellant Comparison Study. The two restart studies, F-1A and J-2S, generated program plans for restarting production of each engine. Special emphasis was placed on determining changes to individual parts due to obsolete materials, changes in OSHA and environmental concerns, new processes available, and any configuration changes to the engines. The Propulsion Database Development task developed a database structure and format which is easy to use and modify while also being comprehensive in the level of detail available. The database structure included extensive engine information and allows for parametric data generation for conceptual engine concepts. The SSME Upper Stage Use task examined the changes needed or desirable to use the SSME as an upper stage engine both in a second stage and in a translunar injection stage. The CERs for Liquid Engines task developed qualitative parametric cost estimating relationships at the engine and major subassembly level for estimating development and production costs of chemical propulsion liquid rocket engines. The Advanced Low Cost Engines task examined propulsion systems for SSTO applications including engine concept definition, mission analysis. trade studies. operating point selection, turbomachinery alternatives, life cycle cost, weight definition. and point design conceptual drawings and component design. The task concentrated on bipropellant engines, but also examined tripropellant engines. The Tripropellant Comparison Study task provided an unambiguous comparison among various tripropellant implementation approaches and cycle choices, and then compared them to similarly designed bipropellant engines in the

  9. Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations

    Energy Technology Data Exchange (ETDEWEB)

    Jacques Hugo; John Forester; David Gertman; Jeffrey Joe; Heather Medema; Julius Persensky; April Whaley

    2013-04-01

    This report presents preliminary research results from the investigation in to the development of new models and guidance for concepts of operations (ConOps) in advanced small modular reactor (aSMR) designs. In support of this objective, three important research areas were included: operating principles of multi-modular plants, functional allocation models and strategies that would affect the development of new, non-traditional concept of operations, and the requiremetns for human performance, based upon work domain analysis and current regulatory requirements. As part of the approach for this report, we outline potential functions, including the theoretical and operational foundations for the development of a new functional allocation model and the identification of specific regulatory requirements that will influence the development of future concept of operations. The report also highlights changes in research strategy prompted by confirmationof the importance of applying the work domain analysis methodology to a reference aSMR design. It is described how this methodology will enrich the findings from this phase of the project in the subsequent phases and help in identification of metrics and focused studies for the determination of human performance criteria that can be used to support the design process.

  10. Advances in the self-burial concept for deep geological disposal of radioactive waste

    International Nuclear Information System (INIS)

    Logan, S.E.

    1996-01-01

    The self-burial concept for deep geological disposal of high-level radioactive waste seeks to utilize the radioactive decay heat emitted by the wastes to melt rock and allow descent by gravity into crystalline rock for isolation. Logan developed the governing equations for the self-disposal process in a paper published in 1973 and 1974 showing that moderate waste concentrations in capsules 1 to 2 m in diameter could descend through granite or basalt to considerable depths, in some cases grater than 10 km. Safety considerations related to filling, handling, and initial cooling of such large capsules prior to release, plus the severe container material environment, has prevented use of the concept. Byalko in Russia recently proposed using a sulfur-filled borehole as a conduit for conveying small capsules down to an accumulation zone at a safe depth of several kilometers. This advance in the self-burial concept overcomes previous problems with self-burial. First, capsules of 0.3 m or less in diameter are relatively simple to fill and handle. Second, investigations indicate that once emplaced at an initial accumulation depth, rock-melting can proceed without an enveloping waste container

  11. Generic Repository Concepts and Thermal Analysis for Advanced Fuel Cycles - 12477

    Energy Technology Data Exchange (ETDEWEB)

    Hardin, Ernest [Sandia National Laboratories, P.O. Box 5800 MS 0736, Albuquerque, NM 87185 (United States); Blink, James [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551-0808 (United States); Carter, Joe [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States); Fratoni, Massimiliano; Greenberg, Harris; Sutton, Mark [Lawrence Livermore National Laboratory (United States); Howard, Robert [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States)

    2012-07-01

    A geologic disposal concept for spent nuclear fuel (SNF) or high-level waste (HLW) consists of three components: waste inventory, geologic setting, and concept of operations. A set of reference geologic disposal concepts has been developed by the U.S. Department of Energy (DOE), Used Fuel Disposition campaign. Reference concepts are identified for crystalline rock, clay/shale, bedded salt, and deep borehole (crystalline basement) geologic settings. These were analyzed for waste inventory cases representing a range of waste types that could be produced by advanced nuclear fuel cycles. Concepts of operation consisting of emplacement mode, repository layout, and engineered barrier descriptions, were selected based on international progress. All of these disposal concepts are enclosed emplacement modes, whereby waste packages are in direct contact with encapsulating engineered or natural materials. Enclosed modes have less capacity to dissipate heat than open modes such as that proposed for a repository at Yucca Mountain. Thermal analysis has identified important relationships between waste package size and capacity, and the duration of surface decay storage needed to meet temperature limits for different disposal concepts. For the crystalline rock and clay/shale repository concepts, a waste package surface temperature limit of 100 deg. C was assumed to prevent changes in clay-based buffer material or clay-rich host rock. Surface decay storage of 50 to 100 years is needed for disposal of high-burnup LWR SNF in 4-PWR packages, or disposal of HLW glass from reprocessing LWR uranium oxide (UOX) fuel. High-level waste (HLW) from reprocessing of metal fuel used in a fast reactor could be disposed after decay storage of 50 years or less. For disposal in salt the rock thermal conductivity is significantly greater, and higher temperatures (200 deg. C) can be tolerated at the waste package surface. Decay storage of 10 years or less is needed for high-burnup LWR SNF in 4-PWR

  12. Advanced payload concepts and system architecture for emerging services in Indian National Satellite Systems

    Science.gov (United States)

    Balasubramanian, E. P.; Rao, N. Prahlad; Sarkar, S.; Singh, D. K.

    2008-07-01

    Over the past two decades Indian Space Research Organization (ISRO) has developed and operationalized satellites to generate a large capacity of transponders for telecommunication service use in INSAT system. More powerful on-board transmitters are built to usher-in direct-to-home broadcast services. These have transformed the Satcom application scenario in the country. With the proliferation of satellite technology, a shift in the Indian market is witnessed today in terms of demand for new services like Broadband Internet, Interactive Multimedia, etc. While it is imperative to pay attention to market trends, ISRO is also committed towards taking the benefits of technological advancement to all round growth of our population, 70% of which dwell in rural areas. The initiatives already taken in space application related to telemedicine, tele-education and Village Resource Centres are required to be taken to a greater height of efficiency. These targets pose technological challenges to build a large capacity and cost-effective satellite system. This paper addresses advanced payload concepts and system architecture along with the trade-off analysis on design parameters in proposing a new generation satellite system capable of extending the reach of the Indian broadband structure to individual users, educational and medical institutions and enterprises for interactive services. This will be a strategic step in the evolution of INSAT system to employ advanced technology to touch every human face of our population.

  13. Advanced Concepts, Technologies and Flight Experiments for NASA's Earth Science Enterprise

    Science.gov (United States)

    Meredith, Barry D.

    2000-01-01

    Over the last 25 years, NASA Langley Research Center (LaRC) has established a tradition of excellence in scientific research and leading-edge system developments, which have contributed to improved scientific understanding of our Earth system. Specifically, LaRC advances knowledge of atmospheric processes to enable proactive climate prediction and, in that role, develops first-of-a-kind atmospheric sensing capabilities that permit a variety of new measurements to be made within a constrained enterprise budget. These advances are enabled by the timely development and infusion of new, state-of-the-art (SOA), active and passive instrument and sensor technologies. In addition, LaRC's center-of-excellence in structures and materials is being applied to the technological challenges of reducing measurement system size, mass, and cost through the development and use of space-durable materials; lightweight, multi-functional structures; and large deployable/inflatable structures. NASA Langley is engaged in advancing these technologies across the full range of readiness levels from concept, to components, to prototypes, to flight experiments, and on to actual science mission infusion. The purpose of this paper is to describe current activities and capabilities, recent achievements, and future plans of the integrated science, engineering, and technology team at Langley Research Center who are working to enable the future of NASA's Earth Science Enterprise.

  14. Integral design concepts of advanced water cooled reactors. Proceedings of a technical committee meeting

    International Nuclear Information System (INIS)

    1997-11-01

    Under the sub-programme on non-electrical applications of advanced reactors, the International Atomic Energy Agency has been providing a worldwide forum for exchange of information on integral reactor concepts. Two Technical Committee meetings were held in 1994 and 1995 on the subject where state-of-the-art developments were presented. Efforts are continuing for the development of advanced nuclear reactors of both evolutionary and innovative design, for electricity, co-generation and heat applications. While single purpose reactors for electricity generation may require small and medium sizes under certain conditions, reactors for heat applications and co-generation would be necessary in the small and medium range and need to be located closer to the load centres. The integral design approach to the development of advanced light water reactors has received special attention over the past few years. Several designs are in the detailed design stage, some are under construction, one prototype is in operation. A need has been felt for guidance on a number of issues, ranging from design objectives to the assessment methodology needed to show how integral designs can meet these objectives, and also to identify their advantages and problem areas. The technical document addresses the current status of the design, safety and operational issues of integral reactors and recommends areas for future development

  15. Advanced Technology Subsonic Transport Study: N+3 Technologies and Design Concepts

    Science.gov (United States)

    Raymer, Daniel P.; Wilson, Jack; Perkins, H. Douglas; Rizzi, Arthur; Zhang, Mengmeng; RamirezPuentes, Alfredo

    2011-01-01

    Conceptual Research Corporation, the Science of the Possible, has completed a two-year study of concepts and technologies for future airliners in the 180-passenger class. This NASA-funded contract was primarily focused on the ambitious goal of a 70 percent reduction in fuel consumption versus the market-dominating Boeing 737-800. The study is related to the N+3 contracts awarded in 2008 by NASA s Aeronautics Research Mission Directorate to teams led by Boeing, GE Aviation, MIT, and Northrop Grumman, but with more modest goals and funding. CRC s contract featured a predominant emphasis on propulsion and fuel consumption, but since fuel consumption depends upon air vehicle design as much as on propulsion technology, the study included notional vehicle design, analysis, and parametric studies. Other NASA goals including NOx and noise reduction are of long-standing interest but were not highlighted in this study, other than their inclusion in the propulsion system provided to CRC by NASA. The B-737-800 was used as a benchmark, parametric tool, and design point of departure. It was modeled in the RDS-Professional aircraft design software then subjected to extensive parametric variations of parasitic drag, drag-due-to-lift, specific fuel consumption, and unsized empty weight. These studies indicated that the goal of a 70 percent reduction in fuel consumption could be attained with roughly a 30 percent improvement in all four parameters. The results were then fit to a Response Surface and coded for ease of use in subsequent trade studies. Potential technologies to obtain such savings were identified and discussed. More than 16 advanced concept designs were then prepared, attempting to investigate almost every possible emerging concept for application to this class airliner. A preliminary assessment of these concepts was done based on their total wetted area after design normalization of trimmed maximum lift. This assessment points towards a Tailless Airliner concept which

  16. Improvement of environmental aspects of thermal power plant operation by advanced control concepts

    Directory of Open Access Journals (Sweden)

    Mikulandrić Robert

    2012-01-01

    Full Text Available The necessity of the reduction of greenhouse gas emissions, as formulated in the Kyoto Protocol, imposes the need for improving environmental aspects of existing thermal power plants operation. Improvements can be reached either by efficiency increment or by implementation of emission reduction measures. Investments in refurbishment of existing plant components or in plant upgrading by flue gas desulphurization, by primary and secondary measures of nitrogen oxides reduction, or by biomass co-firing, are usually accompanied by modernisation of thermal power plant instrumentation and control system including sensors, equipment diagnostics and advanced controls. Impact of advanced control solutions implementation depends on technical characteristics and status of existing instrumentation and control systems as well as on design characteristics and actual conditions of installed plant components. Evaluation of adequacy of implementation of advanced control concepts is especially important in Western Balkan region where thermal power plants portfolio is rather diversified in terms of size, type and commissioning year and where generally poor maintenance and lack of investments in power generation sector resulted in high greenhouse gases emissions and low efficiency of plants in operation. This paper is intended to present possibilities of implementation of advanced control concepts, and particularly those based on artificial intelligence, in selected thermal power plants in order to increase plant efficiency and to lower pollutants emissions and to comply with environmental quality standards prescribed in large combustion plant directive. [Acknowledgements. This paper has been created within WBalkICT - Supporting Common RTD actions in WBCs for developing Low Cost and Low Risk ICT based solutions for TPPs Energy Efficiency increasing, SEE-ERA.NET plus project in cooperation among partners from IPA SA - Romania, University of Zagreb - Croatia and Vinca

  17. Camera Concepts for the Advanced Gamma-Ray Imaging System (AGIS)

    Science.gov (United States)

    Nepomuk Otte, Adam

    2009-05-01

    The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. The incorporation of trigger electronics and signal digitization into the camera are under study. Given the size of AGIS, the camera must be reliable, robust, and cost effective. We are investigating several directions that include innovative technologies such as Geiger-mode avalanche-photodiodes as a possible detector and switched capacitor arrays for the digitization.

  18. AICD -- Advanced Industrial Concepts Division Biological and Chemical Technologies Research Program. 1993 Annual summary report

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, G.; Bair, K.; Ross, J. [eds.

    1994-03-01

    The annual summary report presents the fiscal year (FY) 1993 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1993 (ASR 93) contains the following: A program description (including BCTR program mission statement, historical background, relevance, goals and objectives), program structure and organization, selected technical and programmatic highlights for 1993, detailed descriptions of individual projects, a listing of program output, including a bibliography of published work, patents, and awards arising from work supported by BCTR.

  19. Study of advanced fuel system concepts for commercial aircraft and engines

    Science.gov (United States)

    Versaw, E. F.; Brewer, G. D.; Byers, W. D.; Fogg, H. W.; Hanks, D. E.; Chirivella, J.

    1983-01-01

    The impact on a commercial transport aircraft of using fuels which have relaxed property limits relative to current commercial jet fuel was assessed. The methodology of the study is outlined, fuel properties are discussed, and the effect of the relaxation of fuel properties analyzed. Advanced fuel system component designs that permit the satisfactory use of fuel with the candidate relaxed properties in the subject aircraft are described. The two fuel properties considered in detail are freezing point and thermal stability. Three candidate fuel system concepts were selected and evaluated in terms of performance, cost, weight, safety, and maintainability. A fuel system that incorporates insulation and electrical heating elements on fuel tank lower surfaces was found to be most cost effective for the long term.

  20. Mobility disorders and pain, interrelations that need new research concepts and advanced clinical commitments

    Directory of Open Access Journals (Sweden)

    Sascha Sajer

    2017-12-01

    Full Text Available This Perspective will discuss topics recently suggested by Prof. Helmut Kern, Vienna, Austria, to advance the research activities of his team, that is: Topic A, 10 years post RISE; Topic B, New research for new solutions on old research questions; Topic C, Working groups on nerve regeneration, training-parameters of seniors in different ages, muscle adaptation; and studies of connective tissue and cartilage. This Perspective summarizes some of the basic concepts and of the evidence-based tools for developing further translational research activities. Clinically relevant results will ask for continuous interests of Basic and Applied Myologists and for the support during the next five to ten years of public and private granting agencies. All together, they will end in protocols, devices and multidisciplinary managements for persons suffering with muscle denervation, neuromuscular-related or non-related pain and for the increasing population of old, older and oldest senior citizens in Europe and beyond.

  1. Advanced direct liquefaction concepts for PETC generic units. Quarterly technical progress report, January--March 1992

    Energy Technology Data Exchange (ETDEWEB)

    1992-04-01

    In the Advance Coal Liquefaction Concept Proposal (ACLCP) carbon monoxide (CO) and water have been proposed as the primary reagents in the pretreatment process. The main objective of this project is to develop a methodology for pretreating coal under mild conditions based on a combination of existing processes which have shown great promise in liquefaction, extraction and pyrolysis studies. The aim of this pretreatment process is to partially depolymerise the coal, eliminate oxygen and diminish the propensity for retograde reactions during subsequent liquefaction. The desirable outcome of the CO pretreatment step should be: (1) enhanced liquefaction activity and/or selectivity toward products of higher quality due to chemical modification of the coal structure; (2) cleaner downstream products; (3) overall improvement in operability and process economics.

  2. Surgical treatment of severe osteoporosis including new concept of advanced severe osteoporosis

    Directory of Open Access Journals (Sweden)

    Jin Hwan Kim

    2017-12-01

    Full Text Available Severe osteoporosis is classified as those with a bone mineral density (BMD T-score of −2.5 or lower, and demonstrate one or more of osteoporotic, low-trauma, fragility fractures. According to the general principle of surgical approach, patients with severe osteoporosis require not only more thorough pre- and postoperative treatment plans, but improvements in surgical fixtures and techniques such as the concept of a locking plate to prevent bone deformity and maximizing the blood flow to the fracture site by using a minimally invasive plate osteosynthesis. Arthroplasty is often performed in cases of displaced femoral neck fracture. Otherwise internal fixation for the goal of bone union is the generally accepted option for intertrochanteric, subtrochanteric, and femoral shaft fractures. Most of osteoporotic spine fracture is stable compression fracture, but vertebroplasty or kyphoplasty may be performed some selective patients. If neurological paralysis, severe spinal instability, or kyphotic deformity occurs, open decompression or fusion surgery may be considered. In order to overcome shortcomings of the World Health Organization definition of osteoporosis, we proposed a concept of ‘advanced severe osteoporosis,’ which is defined by the presence of proximal femur fragility fracture or two or more fragility fractures in addition to BMD T-score of −2.5 or less. In conclusion, we need more meticulous approach for surgical treatment of severe osteoporosis who had fragility fracture. In cases of advanced severe osteoporosis, we recommend more aggressive managements using parathyroid hormone and receptor activator of nuclear factor kappa-B ligand monoclonal antibody.

  3. A program to develop advanced EBT [ELMO Bumpy Torus] concepts and international collaboration on the Bumpy Torus concept: Final report

    International Nuclear Information System (INIS)

    1987-01-01

    This project was undertaken to develop innovative concepts for improving the performance of ELMO Bumpy Torus devices in those aspects of plasma confinement that are particularly relevant to an eventual EBT reactor concept. These include effective magnetic utilization using Andreoletti coils, enhanced confinement using positive ambipolar potentials, and attractive divertor concepts that are compatible with formation and maintenance of ELMO rings. Each of the three major objectives was achieved and, except for the divertor studies, documented for publication and presentation at major scientific meetings. This report provides a brief recapitulation of the major results achieved in the form of a collection of those publications, together with this Introduction

  4. Civic consciousness: A viable concept for advancing students’ ability to orient themselves to possible futures?

    Directory of Open Access Journals (Sweden)

    Johan Sandahl

    2015-01-01

    Full Text Available In history didactics the concept of historical consciousness has become an important theoretical framework in developing a meaningful history education. One significant aspect of historical consciousness is to give students a “usable past” to orient to possible futures. Previous research has shown that history is important when students think about the future but that their use of history in meaning-making is simplistic and based on present-day-thinking. Much research has focused on advancing students’ ability to use history in orientation to possible futures, but less attention has been focused on contemporary studies and its role in the process of orientation. By introducing a tentative concept, civic consciousness, the issue of students’ orientation is explored by studying students’ perspectives on democracy in past-present-future. The data consists of 142 narratives and reveals a pattern of normative stances, process orientation and action orientation. These aspects are considered to be important components of civic consciousness and these have implications for how social studies educators should address the challenges of preparing students for the future.

  5. Technology Alignment and Portfolio Prioritization (TAPP): Advanced Methods in Strategic Analysis, Technology Forecasting and Long Term Planning for Human Exploration and Operations, Advanced Exploration Systems and Advanced Concepts

    Science.gov (United States)

    Funaro, Gregory V.; Alexander, Reginald A.

    2015-01-01

    The Advanced Concepts Office (ACO) at NASA, Marshall Space Flight Center is expanding its current technology assessment methodologies. ACO is developing a framework called TAPP that uses a variety of methods, such as association mining and rule learning from data mining, structure development using a Technological Innovation System (TIS), and social network modeling to measure structural relationships. The role of ACO is to 1) produce a broad spectrum of ideas and alternatives for a variety of NASA's missions, 2) determine mission architecture feasibility and appropriateness to NASA's strategic plans, and 3) define a project in enough detail to establish an initial baseline capable of meeting mission objectives ACO's role supports the decision­-making process associated with the maturation of concepts for traveling through, living in, and understanding space. ACO performs concept studies and technology assessments to determine the degree of alignment between mission objectives and new technologies. The first step in technology assessment is to identify the current technology maturity in terms of a technology readiness level (TRL). The second step is to determine the difficulty associated with advancing a technology from one state to the next state. NASA has used TRLs since 1970 and ACO formalized them in 1995. The DoD, ESA, Oil & Gas, and DoE have adopted TRLs as a means to assess technology maturity. However, "with the emergence of more complex systems and system of systems, it has been increasingly recognized that TRL assessments have limitations, especially when considering [the] integration of complex systems." When performing the second step in a technology assessment, NASA requires that an Advancement Degree of Difficulty (AD2) method be utilized. NASA has used and developed or used a variety of methods to perform this step: Expert Opinion or Delphi Approach, Value Engineering or Value Stream, Analytical Hierarchy Process (AHP), Technique for the Order of

  6. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

    Science.gov (United States)

    Deng, Kai; Pertea, Mihaela; Rongvaux, Anthony; Wang, Leyao; Durand, Christine M.; Ghiaur, Gabriel; Lai, Jun; McHugh, Holly L.; Hao, Haiping; Zhang, Hao; Margolick, Joseph B.; Gurer, Cagan; Murphy, Andrew J.; Valenzuela, David M.; Yancopoulos, George D.; Deeks, Steven G.; Strowig, Till; Kumar, Priti; Siliciano, Janet D.; Salzberg, Steven L.; Flavell, Richard A.; Shan, Liang; Siliciano, Robert F.

    2015-01-01

    Despite antiretroviral therapy (ART), HIV-1 persists in a stable latent reservoir1, 2, primarily in resting memory CD4+ T cells3, 4. This reservoir presents a major barrier to the cure of HIV-1 infection. To purge the reservoir, pharmacological reactivation of latent HIV-1 has been proposed5 and tested both in vitro and in vivo6–8. A key remaining question is whether virus-specific immune mechanisms including cytolytic T lymphocytes (CTL) can clear infected cells in ART-treated patients after latency is reversed. Here we show that there is a striking all or none pattern for CTL escape mutations in HIV-1 Gag epitopes. Unless ART is started early, the vast majority (>98%) of latent viruses carry CTL escape mutations that render infected cells insensitive to CTLs directed at common epitopes. To solve this problem, we identified CTLs that could recognize epitopes from latent HIV-1 that were unmutated in every chronically infected patient tested. Upon stimulation, these CTLs eliminated target cells infected with autologous virus derived from the latent reservoir, both in vitro and in patient-derived humanized mice. The predominance of CTL-resistant viruses in the latent reservoir poses a major challenge to viral eradication. Our results demonstrate that chronically infected patients retain a broad spectrum viral-specific CTL response and that appropriate boosting of this response may be required for the elimination of the latent reservoir. PMID:25561180

  7. Proceedings of the International Symposium on Dynamics of Fluids in Fractured Rocks: Concepts and Recent Advances

    Energy Technology Data Exchange (ETDEWEB)

    Faybishenko, B. (ed.)

    1999-02-01

    This publication contains extended abstracts of papers presented at the International Symposium ''Dynamics of Fluids in Fractured Rocks: Concepts and Recent Advances'' held at Ernest Orlando Lawrence Berkeley National Laboratory on February 10-12, 1999. This Symposium is organized in Honor of the 80th Birthday of Paul A. Witherspoon, who initiated some of the early investigations on flow and transport in fractured rocks at the University of California, Berkeley, and at Lawrence Berkeley National Laboratory. He is a key figure in the development of basic concepts, modeling, and field measurements of fluid flow and contaminant transport in fractured rock systems. The technical problems of assessing fluid flow, radionuclide transport, site characterization, modeling, and performance assessment in fractured rocks remain the most challenging aspects of subsurface flow and transport investigations. An understanding of these important aspects of hydrogeology is needed to assess disposal of nu clear wastes, development of geothermal resources, production of oil and gas resources, and remediation of contaminated sites. These Proceedings of more than 100 papers from 12 countries discuss recent scientific and practical developments and the status of our understanding of fluid flow and radionuclide transport in fractured rocks. The main topics of the papers are: Theoretical studies of fluid flow in fractured rocks; Multi-phase flow and reactive chemical transport in fractured rocks; Fracture/matrix interactions; Hydrogeological and transport testing; Fracture flow models; Vadose zone studies; Isotopic studies of flow in fractured systems; Fractures in geothermal systems; Remediation and colloid transport in fractured systems; and Nuclear waste disposal in fractured rocks.

  8. Organization of the 16th Advanced Accelerator Concepts (AAC) Workshop by Stanford University

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Zhirong [Stanford Univ., CA (United States); Hogan, Mark [Stanford Univ., CA (United States)

    2015-09-30

    Essentially all we know today and will learn in the future about the fundamental nature of matter is derived from probing it with directed beams of particles such as electrons, protons, neutrons, heavy ions, and photons. The resulting ability to “see” the building blocks of matter has had an immense impact on society and our standard of living. Over the last century, particle accelerators have changed the way we look at nature and the universe we live in and have become an integral part of the Nation’s technical infrastructure. Today, particle accelerators are essential tools of modern science and technology. The cost and capabilities of accelerators would be greatly enhanced by breakthroughs in acceleration methods and technology. For the last 32 years, the Advanced Accelerator Concepts (AAC) Workshop has acted as the focal point for discussion and development of the most promising acceleration physics and technology. It is a particularly effective forum where the discussion is leveraged and promoted by the unique and demanding feature of the AAC Workshop: the working group structure, in which participants are asked to consider their contributions in terms of even larger problems to be solved. The 16th Advanced Accelerator Concepts (AAC2014) Workshop was organized by Stanford University from July 13 - 18, 2014 at the Dolce Hays Mansion in San Jose, California. The conference had a record 282 attendees including 62 students. Attendees came from 11 countries representing 66 different institutions. The workshop format consisted of plenary sessions in the morning with topical leaders from around the world presenting the latest breakthroughs to the entire workshop. In the late morning and afternoons attendees broke out into eight different working groups for more detailed presentations and discussions that were summarized on the final day of the workshop. In addition, there were student tutorial presentations on two afternoons to provide in depth education and

  9. Fostering clinical reasoning in physiotherapy: comparing the effects of concept map study and concept map completion after example study in novice and advanced learners.

    Science.gov (United States)

    Montpetit-Tourangeau, Katherine; Dyer, Joseph-Omer; Hudon, Anne; Windsor, Monica; Charlin, Bernard; Mamede, Sílvia; van Gog, Tamara

    2017-12-01

    Health profession learners can foster clinical reasoning by studying worked examples presenting fully worked out solutions to a clinical problem. It is possible to improve the learning effect of these worked examples by combining them with other learning activities based on concept maps. This study investigated which combinaison of activities, worked examples study with concept map completion or worked examples study with concept map study, fosters more meaningful learning of intervention knowledge in physiotherapy students. Moreover, this study compared the learning effects of these learning activity combinations between novice and advanced learners. Sixty-one second-year physiotherapy students participated in the study which included a pre-test phase, a 130-min guided-learning phase and a four-week self-study phase. During the guided and self-study learning sessions, participants had to study three written worked examples presenting the clinical reasoning for selecting electrotherapeutic currents to treat patients with motor deficits. After each example, participants engaged in either concept map completion or concept map study depending on which learning condition they were randomly allocated to. Students participated in an immediate post-test at the end of the guided-learning phase and a delayed post-test at the end of the self-study phase. Post-tests assessed the understanding of principles governing the domain of knowledge to be learned (conceptual knowledge) and the ability to solve new problems that have similar (i.e., near transfer) or different (i.e., far transfer) solution rationales as problems previously studied in the examples. Learners engaged in concept map completion outperformed those engaged in concept map study on near transfer (p = .010) and far transfer (p concept map completion led to greater transfer performance than worked examples study combined with concept map study for both novice and advanced learners. Concept map completion

  10. Parabolic Flight Investigation for Advanced Exercise Concept Hardware Hybrid Ultimate Lifting Kit (HULK)

    Science.gov (United States)

    Weaver, A. S.; Funk, J. H.; Funk, N. W.; Sheehan, C. C.; Humphreys, B. T.; Perusek, G. P.

    2015-01-01

    Long-duration space flight poses many hazards to the health of the crew. Among those hazards is the physiological deconditioning of the musculoskeletal and cardiovascular systems due to prolonged exposure to microgravity. To combat this erosion of physical condition space flight may take on the crew, the Human Research Program (HRP) is charged with developing Advanced Exercise Concepts to maintain astronaut health and fitness during long-term missions, while keeping device mass, power, and volume to a minimum. The goal of this effort is to preserve the physical capability of the crew to perform mission critical tasks in transit and during planetary surface operations. The HULK is a pneumatic-based exercise system, which provides both resistive and aerobic modes to protect against human deconditioning in microgravity. Its design targeted the International Space Station (ISS) Advanced Resistive Exercise Device (ARED) high level performance characteristics and provides up to 600 foot pounds resitive loading with the capability to allow for eccentric to concentric (E:C) ratios of higher than 1:1 through a DC motor assist component. The device's rowing mode allows for high cadence aerobic activity. The HULK parabolic flight campaign, conducted through the NASA Flight Opportunities Program at Ellington Field, resulted in the creation of device specific data sets including low fidelity motion capture, accelerometry and both inline and ground reaction forces. These data provide a critical link in understanding how to vibration isolate the device in both ISS and space transit applications. Secondarily, the study of human exercise and associated body kinematics in microgravity allows for more complete understanding of human to machine interface designs to allow for maximum functionality of the device in microgravity.

  11. Integrated concept development of next-step helical-axis advanced stellarators

    Energy Technology Data Exchange (ETDEWEB)

    Warmer, Felix

    2016-04-13

    With the increasing energy demand of mankind and the transformation of our society towards sustainability, nuclear fusion by magnetic confinement is a promising option for the sustainable electricity supply in the future. In view of these prospects this thesis focuses on the concept development of next-step helical-axis advanced stellarator (HELIAS) burning-plasma devices. The HELIAS-line is the continued development of the prototype optimised stellarator Wendelstein 7-X which started operation in 2015. For the integrated concept development of such devices, the approach taken in this work encompasses detailed physics and engineering considerations while also including economic aspects. Starting with physics considerations, the properties of plasma transport and confinement of 3D stellarator configurations are discussed due to their critical importance for the device design. It becomes clear that current empirical confinement time scalings are not sufficient to predict the confinement in future stellarator devices. Therefore, detailed 1D transport simulations are carried out to reduce the uncertainties regarding confinement. Beyond the well-validated neoclassical approach, first attempts are made to include results from state-of-the-art turbulence simulations into the 1D transport simulations to further enhance the predictive capabilities. Next, for the systematic development of consistent design points, stellarator-specific models are developed and implemented in the well-established European systems code PROCESS. This allows a consistent description of an entire HELIAS fusion power plant including physics, engineering, and economic considerations. With the confidence obtained from a verification study, systems studies are for the first time applied for a HELIAS power-plant which shows that the available design window is constrained by the beta-limit. Furthermore, an economic comparison of an exemplary design point to an ''equivalent'' tokamak

  12. Advanced Concepts for Pressure-Channel Reactors: Modularity, Performance and Safety

    Science.gov (United States)

    Duffey, Romney B.; Pioro, Igor L.; Kuran, Sermet

    Based on an analysis of the development of advanced concepts for pressure-tube reactor technology, we adapt and adopt the pressure-tube reactor advantage of modularity, so that the subdivided core has the potential for optimization of the core, safety, fuel cycle and thermal performance independently, while retaining passive safety features. In addition, by adopting supercritical water-cooling, the logical developments from existing supercritical turbine technology and “steam” systems can be utilized. Supercritical and ultra-supercritical boilers and turbines have been operating for some time in coal-fired power plants. Using coolant outlet temperatures of about 625°C achieves operating plant thermal efficiencies in the order of 45-48%, using a direct turbine cycle. In addition, by using reheat channels, the plant has the potential to produce low-cost process heat, in amounts that are customer and market dependent. The use of reheat systems further increases the overall thermal efficiency to 55% and beyond. With the flexibility of a range of plant sizes suitable for both small (400 MWe) and large (1400 MWe) electric grids, and the ability for co-generation of electric power, process heat, and hydrogen, the concept is competitive. The choice of core power, reheat channel number and exit temperature are all set by customer and materials requirements. The pressure channel is a key technology that is needed to make use of supercritical water (SCW) in CANDU®1 reactors feasible. By optimizing the fuel bundle and fuel channel, convection and conduction assure heat removal using passive-moderator cooling. Potential for severe core damage can be almost eliminated, even without the necessity of activating the emergency-cooling systems. The small size of containment structure lends itself to a small footprint, impacts economics and building techniques. Design features related to Canadian concepts are discussed in this paper. The main conclusion is that development of

  13. Indirect coal liquefaction - the first commercial CTL project in the USA

    Energy Technology Data Exchange (ETDEWEB)

    Radtke, K.; Battensby, D.; Marsico, C.; Hooper, M.; Mather, C. [Uhde GmbH (Germany)

    2006-07-01

    The polygeneration of fuels, chemical and power offers an innovative and economically advantageous way to utilise disadvantaged fuels, such as lignite, waste coal and petroleum coke, in a coal-to-liquids (CTL) plant by means of integration of three main process blocks: gasification island to convert coal into clean synthesis gas; Fischer-Tropsch synthesis to convert synthesis gas into clean liquid fuels and chemicals; and combustion of synthesis gas to produce electric power and steam. This paper describes the process and technology side of this indirect coal liquefaction project with key plant data that has been elaborated for a commercial scale CTL project, which is expected to be the first CTL plant in the USA. The plant will use the Shell Coal Gasification process. 6 figs.

  14. Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL response.

    Directory of Open Access Journals (Sweden)

    Ryan M Troyer

    2009-04-01

    Full Text Available Human lymphocyte antigen (HLA-restricted CD8(+ cytotoxic T lymphocytes (CTL target and kill HIV-infected cells expressing cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication fitness. Here, we assess the fitness impact of escape mutations emerging in seven CTL epitopes in the gp120 Env and p24 Gag coding regions of an individual followed longitudinally from the time of acute HIV-1 infection, as well as some of these same epitopes recognized in other HIV-1-infected individuals. Nine dominant mutations appeared in five gp120 epitopes within the first year of infection, whereas all four mutations found in two p24 epitopes emerged after nearly two years of infection. These mutations were introduced individually into the autologous gene found in acute infection and then placed into a full-length, infectious viral genome. When competed against virus expressing the parental protein, fitness loss was observed with only one of the nine gp120 mutations, whereas four had no effect and three conferred a slight increase in fitness. In contrast, mutations conferring CTL escape in the p24 epitopes significantly decreased viral fitness. One particular escape mutation within a p24 epitope was associated with reduced peptide recognition and high viral fitness costs but was replaced by a fitness-neutral mutation. This mutation appeared to alter epitope processing concomitant with a reduced CTL response. In conclusion, CTL escape mutations in HIV-1 Gag p24 were associated with significant fitness costs, whereas most escape mutations in the Env gene were fitness neutral, suggesting a balance between immunologic escape and replicative fitness costs.

  15. Advances and New Concepts in Alcohol-Induced Organelle Stress, Unfolded Protein Responses and Organ Damage

    Directory of Open Access Journals (Sweden)

    Cheng Ji

    2015-06-01

    Full Text Available Alcohol is a simple and consumable biomolecule yet its excessive consumption disturbs numerous biological pathways damaging nearly all organs of the human body. One of the essential biological processes affected by the harmful effects of alcohol is proteostasis, which regulates the balance between biogenesis and turnover of proteins within and outside the cell. A significant amount of published evidence indicates that alcohol and its metabolites directly or indirectly interfere with protein homeostasis in the endoplasmic reticulum (ER causing an accumulation of unfolded or misfolded proteins, which triggers the unfolded protein response (UPR leading to either restoration of homeostasis or cell death, inflammation and other pathologies under severe and chronic alcohol conditions. The UPR senses the abnormal protein accumulation and activates transcription factors that regulate nuclear transcription of genes related to ER function. Similarly, this kind of protein stress response can occur in other cellular organelles, which is an evolving field of interest. Here, I review recent advances in the alcohol-induced ER stress response as well as discuss new concepts on alcohol-induced mitochondrial, Golgi and lysosomal stress responses and injuries.

  16. Advancing the expectancy concept via the interplay between theory and research.

    Science.gov (United States)

    Del Boca, Frances K; Darkes, Jack; Goldman, Mark S; Smith, Gregory T

    2002-06-01

    Four papers from a 2001 Research Society on Alcoholism symposium on expectancy theory and research are summarized. The symposium contributors describe recent advances in expectancy theory and discuss their implications for assessment and for understanding the processes of development and change in the behavioral domain of alcohol use. First, findings are integrated across the diverse domains in which the expectancy concept has been applied. Second, the implications of expectancy theory for the measurement of expectancy structure and process are examined. Third, research and theory regarding alcohol expectancy development and change are presented, with an emphasis on the role of expectancies as mediators of known antecedents of drinking. Finally, an experimental procedure for investigating the causal role of expectancies is described, together with its implications for theory testing and prevention or intervention programming. Collectively, the symposium contributions demonstrate the utility of an integrated expectancy theory for the generation of innovative research operations and new insights regarding behavior development and change. Consistent with the notion of consilience, expectancy theory has demonstrated a convergence of findings across different levels of analysis, as well as across different operations, methods, and research designs.

  17. A Metal Fuel Core Concept for 1000 MWt Advanced Burner Reactor

    International Nuclear Information System (INIS)

    Yang, W.S.; Kim, T.K.; Grandy, C.

    2007-01-01

    This paper describes the core design and performance characteristics of a metal fuel core concept for a 1000 MWt Advanced Burner Reactor. A ternary metal fuel form of U-TRU-Zr was assumed with weapons grade plutonium feed for the startup core and TRU recovered from LWR spent fuel for the recycled equilibrium core. A compact burner core was developed by trade-off between the burnup reactivity loss and TRU conversion ratio, with a fixed cycle length of one-year. In the startup core, the average TRU enrichment is 15.5%, the TRU conversion ratio is 0.81, and the burnup reactivity loss over a cycle is 3.6% Δk. The heavy metal and TRU inventories are 13.1 and 2.0 metric tons, respectively. The average discharge burnup is 93 MWd/kg, and the TRU consumption rate is 55.5 kg/year. For the recycled equilibrium core, the average TRU enrichment is 22.1 %, the TRU conversion ratio is 0.73, and the burnup reactivity loss is 2.2% Δk. The TRU inventory and consumption rate are 2.9 metric tons and 81.6 kg/year, respectively. The evaluated reactivity coefficients provide sufficient negative feedbacks. The control systems provide shutdown margins that are more than adequate. The integral reactivity parameters for quasi-static reactivity balance analysis indicate favorable passive safety features, although detailed safety analyses are required to verify passive safety behavior. (authors)

  18. IMPLEMENTASI CTL DALAM MATA KULIAH PRAKTIKUM METEOROLOGI- KLIMATOLOGI UNTUK MENINGKATKAN KOMPETENSI BEKERJA ILMIAH PADA MAHASISWA JURUSAN PENDIDIKAN GEOGRAFI UNNES

    Directory of Open Access Journals (Sweden)

    Sriyanto Sriyanto

    2014-12-01

    Full Text Available The results of self-evaluation Geography Unnes shows that theaverage duration of the study undergraduate Education Studies Geography is more than 4 years. The main causative factor lies in the preparation of the thesis that the time average of more than 12 months. Difficulty in writing his thesis student allegedly because they are not used to working scientific. The concept or practice of law that have been described in the classroom, it seems less able to develop the ability to work ilmiah.Penelitian is done in theDepartment of Geography at the subject of research students department of Geography. Types of research in the form of class action with some procedures or steps to be carried out. These stages are planning, action, observation / evaluation and ends with reflections. The results show the value than lab report results indicate that by using CTL there is an increasein student how scientific work. This is demonstrated by the increasing number of students who are able to work and make a map of rainfall at each cycle a cycle first, 56. 7 still confusion make maps of rainfall with nets Thiesen, only 43.3% were understand and be able to create a map of rainfall is in the second cycle, students are able to create and draw a map of rainfall with jarinng-nets models Thiesen increased to 83.3%. This result has met the completeness criteria that researchers set that is equal to 75% of the total sample / students. This shows that the models and approaches, students CTL capable and able to work scientifically in solving a particular problem in the lecture.

  19. A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.

    Directory of Open Access Journals (Sweden)

    Yoshimi Tsuda

    2011-08-01

    Full Text Available Human outbreaks of Ebola virus (EBOV are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes.We hypothesize that a vaccine strategy using CMV-based vectors expressing EBOV antigens may be ideally suited for use in inaccessible wildlife populations. To establish a 'proof-of-concept' for CMV-based vaccines against EBOV, we constructed a mouse CMV (MCMV vector expressing a CD8+ T cell epitope from the nucleoprotein (NP of Zaire ebolavirus (ZEBOV (MCMV/ZEBOV-NP(CTL. MCMV/ZEBOV-NP(CTL induced high levels of long-lasting (>8 months CD8+ T cells against ZEBOV NP in mice. Importantly, all vaccinated animals were protected against lethal ZEBOV challenge. Low levels of anti-ZEBOV antibodies were only sporadically detected in vaccinated animals prior to ZEBOV challenge suggesting a role, at least in part, for T cells in protection.This study demonstrates the ability of a CMV-based vaccine approach to protect against an highly virulent human pathogen, and supports the potential for 'disseminating' CMV-based EBOV vaccines to prevent EBOV transmission in wildlife populations.

  20. Plasmodium falciparum CS protein - prime malaria vaccine candidate: definition of the human CTL domain and analysis of its variation

    Directory of Open Access Journals (Sweden)

    Denise L. Doolan

    1992-01-01

    Full Text Available Studies in mice have shown that immunity to malaria sporozoites is mediated primarily by citotoxic T lymphocytes (CTL specific for epitopes within the circumsporozoite (CS protein. Humans, had never been shown to generate CTL against any malaria or other parasite protein. The design of a sub-unit vaccine for humans ralies on the epitopes recognized by CTL being identified and polymorphisms therein being defined. We have developed a novel technique using an entire series of overlapping synthetic peptides to define the epitopes of the Plasmodium falciparum CS protein recognized by human CTL and have analyzed the sequence variation of the protein with respect to the identified CTL epitopic domain. We have demonstrated that some humans can indeed generate CTL. against the P. falciparum CS protein. Furthermore, the extent of variation observed for the CTL recognition domain is finite and the combination of peptides necessary for inclusion in a polyvalent vaccine may be small. If ways can be found to increase immune responsiveness, then a vaccine designed to stimulate CS protein-specific CTL activity may prevent malaria.

  1. Anti-idiotypic antibodies against UV-induced tumor-specific CTL clones. Preparation in syngeneic combination

    International Nuclear Information System (INIS)

    Kuribayashi, K.; Tanaka, C.; Matsubayashi, Y.; Masuda, T.; Udono, H.; Abe, M.; Nakayama, E.; Shiku, H.

    1988-01-01

    In this study, we first established several CTL clones of (BALB/c x C57BL/6)F1 origin that were specific for either syngeneic UV female 1 or UV male 1 fibrosarcoma cell lines. All the CTL clones had Thy-1+ Lyt-2+ L3T4- phenotypes and showed Kd restriction when lysing the corresponding target cells. Sera obtained from syngeneic animals immunized with three CTL clones, 10B-5 for UV female 1, and CTL9 and CTL10 for UV male 1, showed specific inhibition of target cell lysis with the corresponding CTL clones. The inhibitory activities were found in sera of the majority of immunized animals. Because the inhibitory activity resides in protein A-binding fraction, mAb were produced by hybridizing spleen cells of hyperimmune animals. N1-56 was thus obtained from a mouse immunized with 10B-5 CTL clone reactive with UV female 1. N1-56 was clonotype specific, reacting with 10B-5 but not with other CTL lines or leukemia cell lines. No N1-56+ cells were detectable in thymocytes, lymph node cells, or spleen cells of either naive or UV female 1-immune CB6F1 mice. Immunoprecipitation showed that N1-56 reacts with 90,000 Mr molecules on 10B-5 CTL clone under nonreducing conditions and 45,000 Mr molecules under reducing conditions, indicating its reactivities with idiotypic determinants of TCR on the CTL clone. N1-56 inhibited lytic activity of 10B-5, but neither N1-56 nor alpha-10B-5 hyperimmune serum inhibited that of alpha-UV female 1 mixed lymphocyte tumor cell culture cells. N1-56 induced proliferation of 10B-5 without addition of Ag

  2. Physics of plutonium and americium recycling in PWR using advanced fuel concepts

    International Nuclear Information System (INIS)

    Hourcade, E.

    2004-01-01

    PWR waste inventory management is considered in many countries including Frances as one of the main current issues. Pu and Am are the 2 main contents both in term of volume and long term radio-toxicity. Waiting for the Generation IV systems implementation (2035-2050), one of the mid-term solutions for their transmutation involves the use of advanced fuels in Pressurized Water Reactors (PWR). These have to require as little modification as possible of the core internals, the cooling system and fuel cycle facilities (fabrication and reprocessing). The first part of this paper deals with some neutronic characteristics of Pu and/or Am recycling. In a second part, 2 technical solutions MOX-HMR and APA-DUPLEX-84 are presented and the third part is devoted to the study of a few global strategies. The main neutronic parameters to be considered for Pu and Am recycling in PWR are void coefficient, Doppler coefficient, fraction of delayed neutrons and power distribution (especially for heterogeneous configurations). The modification of the moderation ratio, the opportunity to use inert matrices (targets), the optimisation of Uranium, Plutonium and Americium contents are the key parameters to play with. One of the solutions (APA-DUPLEX-84) presented here is a heterogeneous assembly with regular moderation ratio composed with both target fuel rods (Pu and Am embedded in an inert matrix) and standard UO 2 fuel rods. An EPR (European Pressurised Reactor) type reactor, loaded only with assemblies containing 84 peripheral targets, can reach an Americium consumption rate of (4.4; 23 kg/TWh) depending on the assembly concept. For Pu and Am inventories stabilisation, the theoretical fraction of reactors loaded with Pu + Am or Pu assemblies is about 60%. For Americium inventory stabilisation, the fraction decreases down to 16%, but Pu is produced at a rate of 18.5 Kg/TWh (-25% compared to one through UOX cycle)

  3. Final Project Report "Advanced Concept Exploration For Fast Ignition Science Program"

    Energy Technology Data Exchange (ETDEWEB)

    STEPHENS, Richard B.; McLEAN, Harry M.; THEOBALD, Wolfgang; AKLI, Kramer; BEG, Farhat N.; SENTOKU, Yasuiko; SCHUMACHER, Douglas; WEI, Mingsheng S.

    2014-01-31

    The Fast Ignition (FI) Concept for Inertial Confinement Fusion has the potential to provide a significant advance in the technical attractiveness of Inertial Fusion Energy (IFE) reactors. FI differs from conventional “central hot spot” (CHS) target ignition by decoupling compression from heating: using the laser (or heavy ion beam or Z pinch) drive pulse (10’s of ns) to create a dense fuel and a second, much shorter (~10 ps) high intensity pulse to ignite a small region of it. There are two major physics issues concerning this concept; controlling the laser-induced generation of large electron currents and their propagation through high density plasmas. This project has addressed these two significant scientific issues in Relativistic High Energy Density (RHED) physics. Learning to control relativistic laser matter interaction (and the limits and potential thereof) will enable a wide range of applications. While these physics issues are of specific interest to inertial fusion energy science, they are also important for a wide range of other HED phenomena, including high energy ion beam generation, isochoric heating of materials, and the development of high brightness x-ray sources. Generating, controlling, and understanding the extreme conditions needed to advance this science has proved to be challenging: Our studies have pushed the boundaries of physics understanding and are at the very limits of experimental, diagnostic, and simulation capabilities in high energy density laboratory physics (HEDLP). Our research strategy has been based on pursuing the fundamental physics underlying the Fast Ignition (FI) concept. We have performed comprehensive study of electron generation and transport in fast-ignition targets with experiments, theory, and numerical modeling. A major issue is that the electrons produced in these experiments cannot be measured directly—only effects due to their transport. We focused mainly on x-ray continuum photons from bremsstrahlung

  4. Improved best estimate plus uncertainty methodology, including advanced validation concepts, to license evolving nuclear reactors

    International Nuclear Information System (INIS)

    Unal, C.; Williams, B.; Hemez, F.; Atamturktur, S.H.; McClure, P.

    2011-01-01

    Research highlights: → The best estimate plus uncertainty methodology (BEPU) is one option in the licensing of nuclear reactors. → The challenges for extending the BEPU method for fuel qualification for an advanced reactor fuel are primarily driven by schedule, the need for data, and the sufficiency of the data. → In this paper we develop an extended BEPU methodology that can potentially be used to address these new challenges in the design and licensing of advanced nuclear reactors. → The main components of the proposed methodology are verification, validation, calibration, and uncertainty quantification. → The methodology includes a formalism to quantify an adequate level of validation (predictive maturity) with respect to existing data, so that required new testing can be minimized, saving cost by demonstrating that further testing will not enhance the quality of the predictive tools. - Abstract: Many evolving nuclear energy technologies use advanced predictive multiscale, multiphysics modeling and simulation (M and S) capabilities to reduce the cost and schedule of design and licensing. Historically, the role of experiments has been as a primary tool for the design and understanding of nuclear system behavior, while M and S played the subordinate role of supporting experiments. In the new era of multiscale, multiphysics computational-based technology development, this role has been reversed. The experiments will still be needed, but they will be performed at different scales to calibrate and validate the models leading to predictive simulations for design and licensing. Minimizing the required number of validation experiments produces cost and time savings. The use of multiscale, multiphysics models introduces challenges in validating these predictive tools - traditional methodologies will have to be modified to address these challenges. This paper gives the basic aspects of a methodology that can potentially be used to address these new challenges in

  5. A new vesicle trafficking regulator CTL1 plays a crucial role in ion homeostasis.

    Science.gov (United States)

    Gao, Yi-Qun; Chen, Jiu-Geng; Chen, Zi-Ru; An, Dong; Lv, Qiao-Yan; Han, Mei-Ling; Wang, Ya-Ling; Salt, David E; Chao, Dai-Yin

    2017-12-01

    Ion homeostasis is essential for plant growth and environmental adaptation, and maintaining ion homeostasis requires the precise regulation of various ion transporters, as well as correct root patterning. However, the mechanisms underlying these processes remain largely elusive. Here, we reported that a choline transporter gene, CTL1, controls ionome homeostasis by regulating the secretory trafficking of proteins required for plasmodesmata (PD) development, as well as the transport of some ion transporters. Map-based cloning studies revealed that CTL1 mutations alter the ion profile of Arabidopsis thaliana. We found that the phenotypes associated with these mutations are caused by a combination of PD defects and ion transporter misregulation. We also established that CTL1 is involved in regulating vesicle trafficking and is thus required for the trafficking of proteins essential for ion transport and PD development. Characterizing choline transporter-like 1 (CTL1) as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but also vesicle trafficking in general.

  6. Peptide-MHC class I stability is a stronger predictor of CTL immunogenicity than peptide affinity

    DEFF Research Database (Denmark)

    Harndahl, Mikkel Nors; Rasmussen, Michael; Nielsen, Morten

    2012-01-01

    Peptide-MHC class I stability is a stronger predictor of CTL immunogenicity than peptide affinity Mikkel Harndahla, Michael Rasmussena, Morten Nielsenb, Soren Buusa,∗ a Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Denmark b Center for Biological Seq...... al., 2007. J. Immunol. 178, 7890–7901. doi:10.1016/j.molimm.2012.02.025...

  7. Local Model Checking of Weighted CTL with Upper-Bound Constraints

    DEFF Research Database (Denmark)

    Jensen, Jonas Finnemann; Larsen, Kim Guldstrand; Srba, Jiri

    2013-01-01

    We present a symbolic extension of dependency graphs by Liu and Smolka in order to model-check weighted Kripke structures against the logic CTL with upper-bound weight constraints. Our extension introduces a new type of edges into dependency graphs and lifts the computation of fixed-points from...

  8. HLA-A*0201-restricted CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor

    Directory of Open Access Journals (Sweden)

    Tsukahara Tomohide

    2009-06-01

    Full Text Available Abstract Background To develop peptide-based immunotherapy for osteosarcoma, we previously identified papillomavirus binding factor (PBF as a CTL-defined osteosarcoma antigen in the context of HLA-B55. However, clinical application of PBF-based immunotherapy requires identification of naturally presented CTL epitopes in osteosarcoma cells in the context of more common HLA molecules such as HLA-A2. Methods Ten peptides with the HLA-A*0201 binding motif were synthesized from the amino acid sequence of PBF according to the BIMAS score and screened with an HLA class I stabilization assay. The frequency of CTLs recognizing the selected PBF-derived peptide was determined in peripheral blood of five HLA-A*0201+ patients with osteosarcoma using limiting dilution (LD/mixed lymphocyte peptide culture (MLPC followed by tetramer-based frequency analysis. Attempts were made to establish PBF-specific CTL clones from the tetramer-positive CTL pool by a combination of limiting dilution and single-cell sorting. The cytotoxicity of CTLs was assessed by 51Cr release assay. Results Peptide PBF A2.2 showed the highest affinity to HLA-A*0201. CD8+ T cells reacting with the PBF A2.2 peptide were detected in three of five patients at frequencies from 2 × 10-7 to 5 × 10-6. A tetramer-positive PBF A2.2-specific CTL line, 5A9, specifically lysed allogeneic osteosarcoma cell lines that expressed both PBF and either HLA-A*0201 or HLA-A*0206, autologous tumor cells, and T2 pulsed with PBF A2.2. Five of 12 tetramer-positive CTL clones also lysed allogeneic osteosarcoma cell lines expressing both PBF and either HLA-A*0201 or HLA-A*0206 and T2 pulsed with PBF A2.2. Conclusion These findings indicate that PBF A2.2 serves as a CTL epitope on osteosarcoma cells in the context of HLA-A*0201, and potentially, HLA-A*0206. This extends the availability of PBF-derived therapeutic peptide vaccines for patients with osteosarcoma.

  9. The Effects of Advance Organizers and Within-Text Questions on the Learning of a Taxonomy of Concepts. Technical Report No. 357.

    Science.gov (United States)

    Bernard, Michael E.

    This study, presented in three parts, investigated the effects of a group of single-concept instructional variables on the learning at an advanced level of attainment of taxonomy of behavior management concepts. The effects of presenting advance organizers and inserting within-text questions was also examined. The influence of the single-concept…

  10. Impact of uranium-233/thorium cycle on advanced accountability concepts and fabrication facilities. Addendum 2 to application of advanced accountability concepts in mixed oxide fabrication

    International Nuclear Information System (INIS)

    Bastin, J.J.; Jump, M.J.; Lange, R.A.; Crandall, C.C.

    1977-11-01

    The Phase I study of the application of advanced accountability methods (DYMAC) in a uranium/plutonium mixed oxide facility was extended to cover the possible fabrication of uranium-233/thorium fuels. Revisions to Phase II of the DYMAC plan which would be necessitated by such a process are specified. These revisions include shielding requirements, measurement systems, licensing conditions, and safeguards considerations. The impact of the uranium/thorium cycle on a large-scale fuel fabrication facility was also reviewed; it was concluded that the essentially higher radioactivity of uranium/thorium feeds would lead to increased difficulties which tend to preclude early commercial application of the process. An amended schedule for Phase II is included

  11. Impact of receipt of coprocessed uranium/plutonium on advanced accountability concepts and fabrication facilities. Addendum 1 to application of advanced accountability concepts in mixed oxide fabrication

    International Nuclear Information System (INIS)

    Bastin, J.J.; Jump, M.J.; Lange, R.A.; Randall, C.C.

    1977-11-01

    The Phase I study of the application of advanced accountability methods (DYMAC) in a uranium/plutonium mixed oxide facility was extended to assess the effect of coprocessed UO 2 --PuO 2 feed on the observations made in the original Phase I effort and on the proposed Phase II program. The retention of plutonium mixed with uranium throughout the process was also considered. This addendum reports that coprocessed feed would have minimal effect on the DYMAC program, except in the areas of material specifications, starting material delivery schedule, and labor requirements. Each of these areas is addressed, as are the impact of coprocessed feed at a large fuel fabrication facility and the changes needed in the dirty scrap recovery process to maintain the lower plutonium levels which may be required by future nonproliferation philosophy. An amended schedule for Phase II is included

  12. Advanced Electroactive Single Crystal and Polymer Actuator Concepts for Passive Optics, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — TRS Technologies proposes large stroke and high precision piezoelectric single crystal and electroactive polymer actuator concepts?HYBrid Actuation System (HYBAS)...

  13. Concept Analysis and the Advance of Nursing Knowledge: State of the Science.

    Science.gov (United States)

    Rodgers, Beth L; Jacelon, Cynthia S; Knafl, Kathleen A

    2018-04-24

    Despite an overwhelming increase in the number of concept analyses published since the early 1970s, there are significant limitations to the impact of this work in promoting progress in nursing science. We conducted an extensive review of concept analyses published between 1972 and 2017 to identify patterns in analysis and followed this with exploration of an exemplar related to the concept of normalization to demonstrate the capabilities of analysis for promoting concept development and progress. Scoping review of peer-reviewed literature published in the Cumulative Index to Nursing and Allied Health Literature (CINAHL) in which the terms "concept analysis," "concept clarification," and "concept derivation" appeared in any part of the reference. The original search returned 3,489 articles. This initial pool was refined to a final sample of 958 articles published in 223 journals and addressing 604 concepts. A review of citations of the original analysis of the concept of normalization resulted in 75 articles selected for closer examination of the process of concept development. Review showed a clear pattern of repetition of analysis of the same concept, growth in number of published analyses, preponderance of first authors with master's degrees, and 43 distinct descriptions of methods. Review of the 75 citations to the normalization analysis identified multiple ways concept analysis can inform subsequent research and theory development. Conceptual work needs to move beyond the level of "concept analysis" involving clear linkage to the resolution of problems in the discipline. Conceptual work is an important component of progress in the knowledge base of a discipline, and more effective use of concept development activities are needed to maximize the potential of this important work. It is important to the discipline that we facilitate progress in nursing science on a theoretical and conceptual level as a part of cohesive and systematic development of the discipline

  14. Conceptual design of advanced central receiver power systems sodium-cooled receiver concept. Volume 2, Book 2. Appendices. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-03-01

    The appendices include: (A) design data sheets and P and I drawing for 100-MWe commercial plant design, for all-sodium storage concept; (B) design data sheets and P and I drawing for 100-MWe commercial plant design, for air-rock bed storage concept; (C) electric power generating water-steam system P and I drawing and equipment list, 100-MWe commercial plant design; (D) design data sheets and P and I drawing for 281-MWe commercial plant design; (E) steam generator system conceptual design; (F) heat losses from solar receiver surface; (G) heat transfer and pressure drop for rock bed thermal storage; (H) a comparison of alternative ways of recovering the hydraulic head from the advanced solar receiver tower; (I) central receiver tower study; (J) a comparison of mechanical and electromagnetic sodium pumps; (K) pipe routing study of sodium downcomer; and (L) sodium-cooled advanced central receiver system simulation model. (WHK)

  15. Improved best estimate plus uncertainty methodology including advanced validation concepts to license evolving nuclear reactors

    International Nuclear Information System (INIS)

    Unal, Cetin; Williams, Brian; McClure, Patrick; Nelson, Ralph A.

    2010-01-01

    Many evolving nuclear energy programs plan to use advanced predictive multi-scale multi-physics simulation and modeling capabilities to reduce cost and time from design through licensing. Historically, the role of experiments was primary tool for design and understanding of nuclear system behavior while modeling and simulation played the subordinate role of supporting experiments. In the new era of multi-scale multi-physics computational based technology development, the experiments will still be needed but they will be performed at different scales to calibrate and validate models leading predictive simulations. Cost saving goals of programs will require us to minimize the required number of validation experiments. Utilization of more multi-scale multi-physics models introduces complexities in the validation of predictive tools. Traditional methodologies will have to be modified to address these arising issues. This paper lays out the basic aspects of a methodology that can be potentially used to address these new challenges in design and licensing of evolving nuclear technology programs. The main components of the proposed methodology are verification, validation, calibration, and uncertainty quantification. An enhanced calibration concept is introduced and is accomplished through data assimilation. The goal is to enable best-estimate prediction of system behaviors in both normal and safety related environments. To achieve this goal requires the additional steps of estimating the domain of validation and quantification of uncertainties that allow for extension of results to areas of the validation domain that are not directly tested with experiments, which might include extension of the modeling and simulation (M and S) capabilities for application to full-scale systems. The new methodology suggests a formalism to quantify an adequate level of validation (predictive maturity) with respect to required selective data so that required testing can be minimized for

  16. Improved best estimate plus uncertainty methodology including advanced validation concepts to license evolving nuclear reactors

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Laboratory; Williams, Brian [Los Alamos National Laboratory; Mc Clure, Patrick [Los Alamos National Laboratory; Nelson, Ralph A [IDAHO NATIONAL LAB

    2010-01-01

    Many evolving nuclear energy programs plan to use advanced predictive multi-scale multi-physics simulation and modeling capabilities to reduce cost and time from design through licensing. Historically, the role of experiments was primary tool for design and understanding of nuclear system behavior while modeling and simulation played the subordinate role of supporting experiments. In the new era of multi-scale multi-physics computational based technology development, the experiments will still be needed but they will be performed at different scales to calibrate and validate models leading predictive simulations. Cost saving goals of programs will require us to minimize the required number of validation experiments. Utilization of more multi-scale multi-physics models introduces complexities in the validation of predictive tools. Traditional methodologies will have to be modified to address these arising issues. This paper lays out the basic aspects of a methodology that can be potentially used to address these new challenges in design and licensing of evolving nuclear technology programs. The main components of the proposed methodology are verification, validation, calibration, and uncertainty quantification. An enhanced calibration concept is introduced and is accomplished through data assimilation. The goal is to enable best-estimate prediction of system behaviors in both normal and safety related environments. To achieve this goal requires the additional steps of estimating the domain of validation and quantification of uncertainties that allow for extension of results to areas of the validation domain that are not directly tested with experiments, which might include extension of the modeling and simulation (M&S) capabilities for application to full-scale systems. The new methodology suggests a formalism to quantify an adequate level of validation (predictive maturity) with respect to required selective data so that required testing can be minimized for cost

  17. Immune-tolerant elastin-like polypeptides (iTEPs) and their application as CTL vaccine carriers.

    Science.gov (United States)

    Cho, S; Dong, S; Parent, K N; Chen, M

    2016-01-01

    Cytotoxic T lymphocyte (CTL) vaccine carriers are known to enhance the efficacy of vaccines, but a search for more effective carriers is warranted. Elastin-like polypeptides (ELPs) have been examined for many medical applications but not as CTL vaccine carriers. We aimed to create immune tolerant ELPs using a new polypeptide engineering practice and create CTL vaccine carriers using the ELPs. Four sets of novel ELPs, termed immune-tolerant elastin-like polypeptide (iTEP) were generated according to the principles dictating humoral immunogenicity of polypeptides and phase transition property of ELPs. The iTEPs were non-immunogenic in mice. Their phase transition feature was confirmed through a turbidity assay. An iTEP nanoparticle (NP) was assembled from an amphiphilic iTEP copolymer plus a CTL peptide vaccine, SIINFEKL. The NP facilitated the presentation of the vaccine by dendritic cells (DCs) and enhanced vaccine-induced CTL responses. A new ELP design and development practice was established. The non-canonical motif and the immune tolerant nature of the iTEPs broaden our insights about ELPs. ELPs, for the first time, were successfully used as carriers for CTL vaccines. It is feasible to concurrently engineer both immune-tolerant and functional peptide materials. ELPs are a promising type of CTL vaccine carriers.

  18. Advanced Concepts: Enabling Future AF Missions Through the Discovery and Demonstration of Emerging Revolutionary Technologies

    Science.gov (United States)

    2012-10-03

    µmeteoroids, weather, vibrations... Asteroid Mining Breakthrough Physics No known feasible concepts. --- Concept NTF NMS NCA Primary Challenges for Launch...helicon discharge as an excellent space thruster design, given its high throughput, absence of internal electrodes and cathodes , potentially long life...Propellant Plasma Core Ablation Energy Transport Cathode 35 ablative surface; and the resistor-inductor-capacitor circuit model. Thus, the model allows

  19. Advanced Interface for Tactical Security (AITS) Problem Analysis and Concept Definition

    National Research Council Canada - National Science Library

    Murray, S

    1999-01-01

    The Advanced Interface for Tactical Security (AITS) project was initiated to improve the task performance of security forces through technology and design improvements to information display systems...

  20. Recent advances and design options of the aseismic bearing pad concept for reduction of seismic loading

    International Nuclear Information System (INIS)

    Vaidya, N.R.; Musacchio, J.M.; Rizzo, P.C.

    1985-01-01

    The intent of this paper is to: briefly review the developed concepts from a mechanics standpoint; summarize the results of recent testing and applications; discuss the complexities and subtleties of differences between concepts, and highlight the effectiveness of each within selected frequency ranges. On this basis, the paper will provide a forum for application of each concept within the nuclear design community. The potential licensing implications of incorporating the ABP concept into nuclear plant design are be discussed in light of actual experience extrapolated to several dominant regulatory processes; namely the French, German, Japanese, Canadian and American. The intent is to identify potential licensing issues, spur additional research and development in these areas, and continue to bring the concept to the attention of the nuclear community to facilitate acceptance and application. (orig./HP)

  1. Quantifying factors determining the rate of CTL escape and reversion during acute and chronic phases of HIV infection

    Energy Technology Data Exchange (ETDEWEB)

    Ganusov, Vitaly V [Los Alamos National Laboratory; Korber, Bette M [Los Alamos National Laboratory; Perelson, Alan S [Los Alamos National Laboratory

    2009-01-01

    Human immunodeficiency virus (HIV) often evades cytotoxic T cell (CTL) responses by generating variants that are not recognized by CTLs. However, the importance and quantitative details of CTL escape in humans are poorly understood. In part, this is because most studies looking at escape of HIV from CTL responses are cross-sectional and are limited to early or chronic phases of the infection. We use a novel technique of single genome amplification (SGA) to identify longitudinal changes in the transmitted/founder virus from the establishment of infection to the viral set point at 1 year after the infection. We find that HIV escapes from virus-specific CTL responses as early as 30-50 days since the infection, and the rates of viral escapes during acute phase of the infection are much higher than was estimated in previous studies. However, even though with time virus acquires additional escape mutations, these late mutations accumulate at a slower rate. A poor correlation between the rate of CTL escape in a particular epitope and the magnitude of the epitope-specific CTL response suggests that the lower rate of late escapes is unlikely due to a low efficacy of the HIV-specific CTL responses in the chronic phase of the infection. Instead, our results suggest that late and slow escapes are likely to arise because of high fitness cost to the viral replication associated with such CTL escapes. Targeting epitopes in which virus escapes slowly or does not escape at all by CTL responses may, therefore, be a promising direction for the development of T cell based HIV vaccines.

  2. Positive Selection of γδ CTL by TL Antigen Expressed in the Thymus

    Science.gov (United States)

    Tsujimura, Kunio; Takahashi, Toshitada; Morita, Akimichi; Hasegawa-Nishiwaki, Hitomi; Iwase, Shigeru; Obata, Yuichi

    1996-01-01

    To elucidate the function of the mouse TL antigen in the thymus, we have derived two TL transgenic mouse strains by introducing Tla a -3 of A strain origin with its own promoter onto a C3H background with no expression of TL in the thymus. These transgenic mouse strains, both of which express high levels of Tlaa-3-TL antigen in their thymus, were analyzed for their T cell function with emphasis on cytotoxic T lymphocyte (CTL) generation. A T cell response against TL was induced in Tg.Tlaa-3-1, Tg.Tlaa-3-2, and control C3H mice by skin grafts from H-2K b/T3 b transgenic mice, Tg.Con.3-1, expressing T3b-TL ubiquitously. Spleen cells from mice that had rejected the T3b-TL positive skin grafts were restimulated in vitro with Tg.Con.3-1 irradiated spleen cells. In mixed lymphocyte cultures (MLC), approximately 20% and 15% of Thy-1+ T cells derived from Tg.Tlaa-3-1 and Tg.Tlaa-3-2, respectively, expressed TCRγδ, whereas almost all those from C3H expressed TCRαβ. The MLC from Tg.Tlaa-3-2 and C3H demonstrated high CTL activity against TL, while those from Tg.Tlaa-3-1 had little or none. The generation of γδ CTL recognizing TL in Tg.Tlaa-3-2, but not C3H mice, was confirmed by the establishment of CTL clones. A total of 14 γδ CTL clones were established from Tg.Tlaa-3-2, whereas none were obtained from C3H. Of the 14 γδ CTL clones, 8 were CD8+ and 6 were CD4−CD8− double negative. The CTL activity of all these clones was TL specific and inhibited by anti-TL, but not by anti-H-2 antibodies, demonstrating that they recognize TL directly without antigen presentation by H-2. The CTL activity was blocked by antibodies to TCRγδ and CD3, and also by antibodies to CD8α and CD8β in CD8+ clones, showing that the activity was mediated by TCRγδ and coreceptors. The thymic origin of these γδ CTL clones was indicated by the expression of Thy-1 and Ly-1 (CD5), and also CD8αβ heterodimers in CD8+ clones on their surfaces and by the usage of TCR Vγ4 chains in 12 of

  3. Advanced Wind Turbine Drivetrain Concepts: Workshop Report, June 29-30, 2010

    Energy Technology Data Exchange (ETDEWEB)

    DOE, EERE

    2010-12-01

    This report presents key findings from the Department of Energy's Advanced Drivetrain Workshop, held on June 29-30, 2010 in Broomfield, Colorado, to assess different advanced drivetrain technologies, their relative potential to improve the state-of-the-art in wind turbine drivetrains, and the scope of research and development needed for their commercialization in wind turbine applications.

  4. Advanced plutonium assembly (apa): evolution of the concept, neutron and thermal-mechanic constraints

    International Nuclear Information System (INIS)

    Porta, J.; Gastaldi, B.; Krakowiak-Aillaud, C.; Buffe, L.

    2002-01-01

    The APA concept was developed with the aim of increasing the PWR capacity to burn plutonium emerging from the recycling of irradiated fuels in the French park of nuclear power plants. At first, a concept using annular pins was optimised to allow a good consumption of plutonium while preserving an acceptable neutron control. To cope with the technological problems and those posed by the manufacture of these annular pins, an alternative concept is presented here. It poses as initial conditions the conservation of both the plutonium balance and the respect of the reactivity control. (authors)

  5. PERBEDAAN JENIS PEMBELAJARAN MODEL CTL DAN DISCOVERY LEARNING DITINJAU DARI MOTIVASI BELAJAR IPS

    Directory of Open Access Journals (Sweden)

    Elpri Darta Putra

    2015-06-01

    Full Text Available Tujuan penelitian ini adalah menganalisis perbedaan motivasi belajar siswa melalui model pembelajaran Contextual Teaching And Learning, Discovery Learning dan pembelajaran ekspositori. Subjek penelitian ini adalah siswa kelas IV SDN Kuningan 01, SDN Kuningan 04, dan SDN Dadapsari Semarang tahun ajaran 2014/2015. Penelitian dilakukan empat kali pertemuan. Instrumen penelitian ini adalah angket yang berupa butir-butir pernyataan dan lembar wawancara guru. Penelitian ini dalam bentuk penelitian quasi-experimental atau eksperimen semu. Jumlah sampel dalam penelitian ini adalah 85 siswa. Hasil penelitian tentang motivasi belajar siswa di kelas empat menunjukkan bahwa melalui model pembelajaran CTL motivasi belajar siswa dengan nilai rata-rata pada kelas tersebut 81,92 melalui model pembelajaran Discovery Learning 77,66dan melalui pembelajaran ekspositori memiliki rata-rata 52.28. Berdasarkan hasil penelitian tersebut terdapat perbedaan antara motivasi belajar siswa yang menggunakan model pembelajaran CTL, Discovery Learning dan ekspositori, pembelajaran melalui model CTL lebih baik dari pembelajaran melalui model discovery learning dan ekspositrori. The purpose of this study was to analyze differences in student motivation through learning model Contextual Teaching And Learning, Discovery Learning and expository. Subjects in this study were fourth grade students of SDN 01 Brass, Brass SDN 04, and SDN Dadapsari Semarang academic year 2014/2015. The study was conducted four meetings. Data collection instruments in this study was a questionnaire in the form of grains statements and teacher questionnaires. The study is in the form of quasi-experimental or quasi-experimental, the number of samples in this study were 85 students .. The results of students' motivation in the fourth grade showed that through learning model CTL student motivation with the average value in the class 81, 92 through Discovery Learning learning model through expository 77.66 and

  6. Compilation of Energy Efficient Concepts in Advanced Aircraft Design and Operations. Volume 1. Technical report

    National Research Council Canada - National Science Library

    Clyman, Milton

    1980-01-01

    .... The search addressed the technologies necessary to support next generation (IOC 1990+) air vehicle design and operation concepts that will reduce the requirement for natural petroleum-derived energy...

  7. Accuracy Improvement Capability of Advanced Projectile Based on Course Correction Fuze Concept

    OpenAIRE

    Elsaadany, Ahmed; Wen-jun, Yi

    2014-01-01

    Improvement in terminal accuracy is an important objective for future artillery projectiles. Generally it is often associated with range extension. Various concepts and modifications are proposed to correct the range and drift of artillery projectile like course correction fuze. The course correction fuze concepts could provide an attractive and cost-effective solution for munitions accuracy improvement. In this paper, the trajectory correction has been obtained using two kinds of course corr...

  8. Advanced Melting Technologies: Energy Saving Concepts and Opportunities for the Metal Casting Industry

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2005-11-01

    The study examines current and emerging melting technologies and discusses their technical barriers to scale-up issues and research needed to advance these technologies, improving melting efficiency, lowering metal transfer heat loss, and reducing scrap.

  9. Status and future directions for advanced accelerator research - conventional and non-conventional collider concepts

    International Nuclear Information System (INIS)

    Siemann, R.H.

    1997-01-01

    The relationship between advanced accelerator research and future directions for particle physics is discussed. Comments are made about accelerator research trends in hadron colliders, muon colliders, and e + 3 - linear colliders

  10. Advanced concepts, analysis approaches and criteria for nuclear piping system design

    International Nuclear Information System (INIS)

    Tang, H.T.; Tagart, S.W. Jr.; Tang, Y.K.

    1992-01-01

    Recent research in piping system design and analysis has resulted in advancements on damping values, independent support motion (ISM), static coefficient method, simplified inelastic method and ASME code criteria changes. In the support area, passive type of supports such as energy-absorbing device and gap stopper have been developed. These advancements provide bases for improved and cost-effective design of future nuclear piping systems. (author)

  11. African Cultural Concept of Death and the Idea of Advance Care Directives.

    Science.gov (United States)

    Ekore, Rabi Ilemona; Lanre-Abass, Bolatito

    2016-01-01

    An advance care directive is a person's oral or written instructions about his or her future medical care, if he or she becomes unable to communicate. It may be in written or oral form. Africans ordinarily do not encourage the contemplation of death or any discussion about their own or their loved ones' death. According to the African belief system, life does not end with death, but continues in another realm. Becoming an ancestor after death is a desirable goal of every individual, a feat which cannot be achieved if an individual asks for an unnatural death by attempting to utilize advance care directives. Advance care directives are considered to be too individualistic for communitarian societies such as Africa. Coupled with the communitarian nature of African societies are issues such as lack of awareness of advance directives, fear of death and grief, and the African cultural belief system, which are potential barriers to the utilization of advance care directives in the African setting. Hence, the need for culture sensitivity which makes it imperative that patient's family and loved ones are carried along as far as possible, without compromising the autonomy of the patient in question when utilizing advance care directives.

  12. A mathematical model for CTL effect on a latently infected cell inclusive HIV dynamics and treatment

    Science.gov (United States)

    Tarfulea, N. E.

    2017-10-01

    This paper investigates theoretically and numerically the effect of immune effectors, such as the cytotoxic lymphocyte (CTL), in modeling HIV pathogenesis (via a newly developed mathematical model); our results suggest the significant impact of the immune response on the control of the virus during primary infection. Qualitative aspects (including positivity, boundedness, stability, uncertainty, and sensitivity analysis) are addressed. Additionally, by introducing drug therapy, we analyze numerically the model to assess the effect of treatment consisting of a combination of several antiretroviral drugs. Our results show that the inclusion of the CTL compartment produces a higher rebound for an individual's healthy helper T-cell compartment than drug therapy alone. Furthermore, we quantitatively characterize successful drugs or drug combination scenarios.

  13. Integrated Evaluation Concept to Assess the Efficacy of Advanced Wastewater Treatment Processes for the Elimination of Micropollutants and Pathogens.

    Science.gov (United States)

    Ternes, Thomas A; Prasse, Carsten; Eversloh, Christian Lütke; Knopp, Gregor; Cornel, Peter; Schulte-Oehlmann, Ulrike; Schwartz, Thomas; Alexander, Johannes; Seitz, Wolfram; Coors, Anja; Oehlmann, Jörg

    2017-01-03

    A multidisciplinary concept has been developed to compare advanced wastewater treatment processes for their efficacy of eliminating micropollutants and pathogens. The concept is based on (i) the removal/formation of selected indicator substances and their transformation products (TPs), (ii) the assessment of ecotoxicity via in vitro tests, and (iii) the removal of pathogens and antibiotic resistant bacteria. It includes substances passing biological wastewater treatment plants regulated or proposed to be regulated in the European Water Framework Directive, TPs formed in biological processes or during ozonation, agonistic/antagonistic endocrine activities, mutagenic/genotoxic activities, cytotoxic activities, further activities like neurotoxicity as well as antibiotics resistance genes, and taxonomic gene markers for pathogens. At a pilot plant, ozonation of conventionally treated wastewater resulted in the removal of micropollutants and pathogens and the reduction of estrogenic effects, whereas the in vitro mutagenicity increased. Subsequent post-treatment of the ozonated water by granular activated carbon (GAC) significantly reduced the mutagenic effects as well as the concentrations of remaining micropollutants, whereas this was not the case for biofiltration. The results demonstrate the suitability of the evaluation concept to assess processes of advanced wastewater treatment including ozonation and GAC by considering chemical, ecotoxicological, and microbiological parameters.

  14. Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions.

    Science.gov (United States)

    Wang, Chuang-Wei; Yang, Lan-Yan; Chen, Chun-Bing; Ho, Hsin-Chun; Hung, Shuen-Iu; Yang, Chih-Hsun; Chang, Chee-Jen; Su, Shih-Chi; Hui, Rosaline Chung-Yee; Chin, See-Wen; Huang, Li-Fang; Lin, Yang Yu-Wei; Chang, Wei-Yang; Fan, Wen-Lang; Yang, Chin-Yi; Ho, Ji-Chen; Chang, Ya-Ching; Lu, Chun-Wei; Chung, Wen-Hung

    2018-03-01

    Cytotoxic T lymphocyte-mediated (CTL-mediated) severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are rare but life-threatening adverse reactions commonly induced by drugs. Although high levels of CTL-associated cytokines, chemokines, or cytotoxic proteins, including TNF-α and granulysin, were observed in SJS-TEN patients in recent studies, the optimal treatment for these diseases remains controversial. We aimed to evaluate the efficacy, safety, and therapeutic mechanism of a TNF-α antagonist in CTL-mediated SCARs. We enrolled 96 patients with SJS-TEN in a randomized trial to compare the effects of the TNF-α antagonist etanercept versus traditional corticosteroids. Etanercept improved clinical outcomes in patients with SJS-TEN. Etanercept decreased the SCORTEN-based predicted mortality rate (predicted and observed rates, 17.7% and 8.3%, respectively). Compared with corticosteroids, etanercept further reduced the skin-healing time in moderate-to-severe SJS-TEN patients (median time for skin healing was 14 and 19 days for etanercept and corticosteroids, respectively; P = 0.010), with a lower incidence of gastrointestinal hemorrhage in all SJS-TEN patients (2.6% for etanercept and 18.2% for corticosteroids; P = 0.03). In the therapeutic mechanism study, etanercept decreased the TNF-α and granulysin secretions in blister fluids and plasma (45.7%-62.5% decrease after treatment; all P etanercept serves as an effective alternative for the treatment of CTL-mediated SCARs. ClinicalTrials.gov NCT01276314. Ministry of Science and Technology of Taiwan.

  15. Some advanced concepts of mobile robotics for plant inspection and maintenance

    International Nuclear Information System (INIS)

    Halme, A.

    1994-01-01

    The paper introduces two concepts in robotics the feasibility of which are presently being studied for plant inspection/maintenance purposes. One of them is a walking machine platform which utilizes walking on discrete set of points making it possible to feed energy trough legs and/or grip on fixing points when needing strong support or climbing on walls. The other is a robot society concept in which the work is distributed among the member robots of the society. The society has an inner communication system trough which information is spread between the members. The control system of the society takes care of the task coordination and communication between the society and the user. As a special feature energy distribution within the society is considered. The concept is suggested for inspection and cleaning type of work in process equipment area and also inside processes in some cases. (author)

  16. IMPLEMENTASI PENDEKATAN CONTEXTUAL TEACHING AND LEARNING (CTL BERBASIS WEB PADA PRAKTIKUM KIMIA

    Directory of Open Access Journals (Sweden)

    Anggun Zuhaida

    2016-11-01

    The learning process chemistry in SMA/MA still tends to be a conventional means are still teoritik out the lesson and had yet to develop the ability of students to the maximum. Practical learning can provide an opportunity to students to test and apply the theory by using the facilities of the laboratory and outside the laboratory. This research aims to know the influence of the use of web-based CTL approach towards learning outcomes subject matter the reaction rate. The population in this research is the grade XI IPA in MAN 2 Kudus. Sampling is done using cluster random sampling techniques, namely class XI IPA 4 as a class experiments who got the treatment by using web-based CTL approach and Class XI IPA 5 as a control class get conventional learning with media powerpoint. Method of data collection in this research is a method of documentation, tests, observation and question form. Test hypotheses using the coefficient of biserial correlation and coefficient of determination and acquired rb 0.65 with the amount of contributions 42,11%. The conclusion is the use of web-based CTL influential approach towards learning outcomes subject matter the rate of grade XI IPA MAN 2 Kudus with contributions 42,11%.

  17. TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation

    Directory of Open Access Journals (Sweden)

    Dirk Wohlleber

    2012-09-01

    Full Text Available Viruses can escape cytotoxic T cell (CTL immunity by avoiding presentation of viral components via endogenous MHC class I antigen presentation in infected cells. Cross-priming of viral antigens circumvents such immune escape by allowing noninfected dendritic cells to activate virus-specific CTLs, but they remain ineffective against infected cells in which immune escape is functional. Here, we show that cross-presentation of antigen released from adenovirus-infected hepatocytes by liver sinusoidal endothelial cells stimulated cross-primed effector CTLs to release tumor necrosis factor (TNF, which killed virus-infected hepatocytes through caspase activation. TNF receptor signaling specifically eliminated infected hepatocytes that showed impaired anti-apoptotic defense. Thus, CTL immune surveillance against infection relies on two similarly important but distinct effector functions that are both MHC restricted, requiring either direct antigen recognition on target cells and canonical CTL effector function or cross-presentation and a noncanonical effector function mediated by TNF.

  18. TNF-induced target cell killing by CTL activated through cross-presentation.

    Science.gov (United States)

    Wohlleber, Dirk; Kashkar, Hamid; Gärtner, Katja; Frings, Marianne K; Odenthal, Margarete; Hegenbarth, Silke; Börner, Carolin; Arnold, Bernd; Hämmerling, Günter; Nieswandt, Bernd; van Rooijen, Nico; Limmer, Andreas; Cederbrant, Karin; Heikenwalder, Mathias; Pasparakis, Manolis; Protzer, Ulrike; Dienes, Hans-Peter; Kurts, Christian; Krönke, Martin; Knolle, Percy A

    2012-09-27

    Viruses can escape cytotoxic T cell (CTL) immunity by avoiding presentation of viral components via endogenous MHC class I antigen presentation in infected cells. Cross-priming of viral antigens circumvents such immune escape by allowing noninfected dendritic cells to activate virus-specific CTLs, but they remain ineffective against infected cells in which immune escape is functional. Here, we show that cross-presentation of antigen released from adenovirus-infected hepatocytes by liver sinusoidal endothelial cells stimulated cross-primed effector CTLs to release tumor necrosis factor (TNF), which killed virus-infected hepatocytes through caspase activation. TNF receptor signaling specifically eliminated infected hepatocytes that showed impaired anti-apoptotic defense. Thus, CTL immune surveillance against infection relies on two similarly important but distinct effector functions that are both MHC restricted, requiring either direct antigen recognition on target cells and canonical CTL effector function or cross-presentation and a noncanonical effector function mediated by TNF. Copyright © 2012 The Authors. Published by Elsevier Inc. All rights reserved.

  19. PENGARUH PENDEKATAN CONTEXTUAL TEACHING AND LEARNING (CTL BERBANTUAN MEDIA POWERPOINT TERHADAP PENINGKATAN HASIL BELAJAR IPA FISIKA

    Directory of Open Access Journals (Sweden)

    Suprianto Suprianto

    2016-12-01

    Full Text Available Berdasarkan hasil wawancara terbatas dengan sebagian guru IPA fisika MTs di kecamatan Camplong Kabupaten Sampang didapatkan informasi bahwa hasil belajar siswa masih rendah dibawah KKM yang sudah ditentukan pihak sekolah. Hal ini disebabkan karena kurangnya penggunaan media pembelajaran, proses pembelajaran masih bersifat teacher centered sehingga sebagian besar siswa tidak mampu menghubungkan antara apa yang mereka pelajari dengan bagaimana pemanfaatannya dalam kehidupan nyata. Adapun tujuan penelitian ini adalah untuk mengidentifikasi pengaruh pendekatan CTL berbantuan media powerpoint terhadap peningkatan hasil belajar IPA fisika siswa. Metode penelitian yang digunakan adalah metode Quasi Experimen dengan menggunakan Nonrandomized Control Group Pretest-Postest Design dan dibagi menjadi dua kelompok, yaitu kelompok eksperimen dan kelompok kontrol. Instrumen penelitian yang digunakan berupa tes objektif bentuk pilihan ganda. Tes ini terdiri dari empat pilihan (opsi dan hasilnya diuji melalui statistik uji “t”. Dari hasil perhitungan diperoleh nilai thitung sebesar 10,81 sedangkan ttabel sebesar 2,021 pada taraf signifikansi 0,05 atau dapat diketahui thitung > ttabel. Dari perhitungan N-gain, dapat dinyatakan bahwa peningkatan hasil belajar fisika yang diterapkan pendekatan CTL berbantuan media powerpoint lebih tinggi dari pada pembelajaran konvensional yaitu 0,71 > 0,52. Berdasarkan hasil analisis statistika dan deskriptif maka dapat di simpulkan bahwa terdapat pengaruh yang signifikan pendekatan CTL berbantuan media powerpoint terhadap peningkatan hasil belajar fisika siswa di kelas VIII MTs.

  20. Systematic design of an intra-cycle fueling control system for advanced diesel combustion concepts

    NARCIS (Netherlands)

    Kefalidis, L.

    2017-01-01

    This technical report presents a systematic approach for the design and development of an intra-cycle fueling control system for diesel combustion concepts. A high level system was developed and implemented on an experimental engine setup. Implementation and experimental validation are performed for

  1. Advanced nickel/hydrogen dependent pressure vessel (DPV) cell and battery concepts

    Energy Technology Data Exchange (ETDEWEB)

    Caldwell, D.B. [Technologies Div., Eagle Picher Industries, Inc., Joplin, MO (United States); Fox, C.L. [Technologies Div., Eagle Picher Industries, Inc., Joplin, MO (United States); Miller, L.E. [Technologies Div., Eagle Picher Industries, Inc., Joplin, MO (United States)

    1997-03-01

    The dependent pressure vessel (DPV) nickel/hydrogen (NiH{sub 2}) design is being developed by Eagle-Picher industries, Inc. (EPI) as an advanced battery for military and commercial aerospace and terrestrial applications. The DPV cell design offers high specific energy and energy density as well as reduced cost, while retaining the established individual pressure vessel (IPV) technology, flight heritage and database. This advanced DPV design also offers a more efficient mechanical, electrical and thermal cell and battery configuration and a reduced parts count. The DPV battery design promotes compact, minimum volume packaging and weight efficiency, and delivers cost and weight savings with minimal design risks. (orig.)

  2. Concept of Advanced Back-up Control Panel Design of Digital Main Control Room

    International Nuclear Information System (INIS)

    Jiang, Guo Jin; Sun, Yong Bin; Tan, Ke; Zhang, Li Ming; Shi, Ji; Zhang, Xue Gang; Huang, Wei Jun; Mao, Ting; Liu Yanzi

    2011-01-01

    Back-up control panel (BCP) of digital main control room (DMCR) is the backup means for main computerized control means (MCM). This paper focus on technical issues for advanced design of Backup Panel (BCP) for CPR1000 using qualified computer-based video display unit to display plant process indication and alarms. HFE issues also have been considered in the BCP design. Then, mean to fulfill safety target of NPP, best ergonomic effect has been described. At last conclusion on advanced BCP design is provided

  3. Concept of Advanced Back-up Control Panel Design of Digital Main Control Room

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Guo Jin; Sun, Yong Bin; Tan, Ke; Zhang, Li Ming; Shi, Ji; Zhang, Xue Gang; Huang, Wei Jun; Mao, Ting; Liu Yanzi [China Nuclear Power Engineering Company, Shenzen (China)

    2011-08-15

    Back-up control panel (BCP) of digital main control room (DMCR) is the backup means for main computerized control means (MCM). This paper focus on technical issues for advanced design of Backup Panel (BCP) for CPR1000 using qualified computer-based video display unit to display plant process indication and alarms. HFE issues also have been considered in the BCP design. Then, mean to fulfill safety target of NPP, best ergonomic effect has been described. At last conclusion on advanced BCP design is provided.

  4. Teaching Pediatric Nursing Concepts to Non-Pediatric Nurses Using an Advance Organizer

    Science.gov (United States)

    Bell, Julie Ann

    2013-01-01

    Non-pediatric nurses in rural areas often care for children in adult units, emergency departments, and procedural areas. A half-day program about pediatric nursing using constructivist teaching strategies including an advance organizer, case studies, and simulation was offered at a community hospital in Western North Carolina. Nurses reported a…

  5. A Model for Infusing Energy Concepts into Vocational Education Programs. Advanced Solar Systems.

    Science.gov (United States)

    Delta Vocational Technical School, Marked Tree, AR.

    This instructional unit consists of materials designed to help students understand terms associated with solar energy; identify components of advanced solar systems; and identify applications of solar energy in business, industry, agriculture, and photovoltaics. Included in the unit are the following materials: suggested activities, instructional…

  6. CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.

    Directory of Open Access Journals (Sweden)

    Sylvain Cardinaud

    2011-05-01

    Full Text Available Cytotoxic CD8+ T cells (CTLs play a critical role in controlling viral infections. HIV-infected individuals develop CTL responses against epitopes derived from viral proteins, but also against cryptic epitopes encoded by viral alternative reading frames (ARF. We studied here the mechanisms of HIV-1 escape from CTLs targeting one such cryptic epitope, Q9VF, encoded by an HIVgag ARF and presented by HLA-B*07. Using PBMCs of HIV-infected patients, we first cloned and sequenced proviral DNA encoding for Q9VF. We identified several polymorphisms with a minority of proviruses encoding at position 5 an aspartic acid (Q9VF/5D and a majority encoding an asparagine (Q9VF/5N. We compared the prevalence of each variant in PBMCs of HLA-B*07+ and HLA-B*07- patients. Proviruses encoding Q9VF/5D were significantly less represented in HLA-B*07+ than in HLA-B*07- patients, suggesting that Q9FV/5D encoding viruses might be under selective pressure in HLA-B*07+ individuals. We thus analyzed ex vivo CTL responses directed against Q9VF/5D and Q9VF/5N. Around 16% of HLA-B*07+ patients exhibited CTL responses targeting Q9VF epitopes. The frequency and the magnitude of CTL responses induced with Q9VF/5D or Q9VF/5N peptides were almost equal indicating a possible cross-reactivity of the same CTLs on the two peptides. We then dissected the cellular mechanisms involved in the presentation of Q9VF variants. As expected, cells infected with HIV strains encoding for Q9VF/5D were recognized by Q9VF/5D-specific CTLs. In contrast, Q9VF/5N-encoding strains were neither recognized by Q9VF/5N- nor by Q9VF/5D-specific CTLs. Using in vitro proteasomal digestions and MS/MS analysis, we demonstrate that the 5N variation introduces a strong proteasomal cleavage site within the epitope, leading to a dramatic reduction of Q9VF epitope production. Our results strongly suggest that HIV-1 escapes CTL surveillance by introducing mutations leading to HIV ARF-epitope destruction by proteasomes.

  7. Cancer survivorship: Advancing the concept in the context of colorectal cancer.

    Science.gov (United States)

    Drury, Amanda; Payne, Sheila; Brady, Anne-Marie

    2017-08-01

    Previous conceptualizations of cancer survivorship have focused on heterogeneous cancer survivors, with little consideration of the validity of conclusions for homogeneous tumour groups. This paper aims to examine the concept of cancer survivorship in the context of colorectal cancer (CRC). Rodgers' (1989) Evolutionary Method of Concept Analysis guided this study. A systematic search of PUBMED, CINAHL, PsycINFO and The Cochrane Library was conducted in November 2016 to identify studies of CRC survivorship. The Braun and Clarke (2006) framework guided the analysis and interpretation of data extracted from eighty-five publications. Similar to general populations of cancer survivors, CRC survivors experience survivorship as an individual, life-changing process, punctuated by uncertainty and a duality of positive and negative outcomes affecting quality of life. However, CRC survivors experience specific concerns arising from the management of their disease. The concept of cancer survivorship has evolved over the past decade as the importance of navigating the healthcare system and its resources, and the constellation of met and unmet needs of cancer survivors are realised. The results highlight core similarities between survivorship in the context of CRC and other tumour groups, but underlines issues specific to CRC survivorship. Communication and support are key issues in survivorship care which may detrimentally affect CRC survivors' well-being if they are inadequately addressed. Healthcare professionals (HCP's) therefore have a duty to ensure cancer survivors' health, information and supportive care needs are met in the aftermath of treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Advanced storage concepts for solar thermal systems in low energy buildings. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Furbo, S.; Andersen, Elsa; Schultz, Joergen M.

    2006-04-07

    The aim of Task 32 is to develop new and advanced heat storage systems which are economic and technical suitable as long-term heat storage systems for solar heating plants with a high degree of coverage. The project is international and Denmark's participation has focused on Subtask A, C, and D. In Subtask A Denmark has contributed to a status report about heat storage systems. In Subtask C Denmark has focused on liquid thermal storage tanks based on NaCH{sub 3}COO?3H{sub 2}O with a melting point of 58 deg. C. Theoretical and experimental tests have been conducted in order to establish optimum conditions for storage design. In Subtask D theoretical and experimental tests of optimum designs for advanced water tanks for solar heating plants for combined space heating and domestic hot water have been conducted. (BA)

  9. Advanced transportation system studies technical area 3: Alternate propulsion subsystem concepts, volume 3

    Science.gov (United States)

    Levak, Daniel

    1993-01-01

    The objective of this contract was to provide definition of alternate propulsion systems for both earth-to-orbit (ETO) and in-space vehicles (upper stages and space transfer vehicles). For such propulsion systems, technical data to describe performance, weight, dimensions, etc. was provided along with programmatic information such as cost, schedule, needed facilities, etc. Advanced technology and advanced development needs were determined and provided. This volume separately presents the various program cost estimates that were generated under three tasks: the F-1A Restart Task, the J-2S Restart Task, and the SSME Upper Stage Use Task. The conclusions, technical results, and the program cost estimates are described in more detail in Volume 1 - Executive Summary and in individual Final Task Reports.

  10. Advanced Transportation System Studies. Technical Area 3: Alternate Propulsion Subsystems Concepts. Volume 3; Program Cost Estimates

    Science.gov (United States)

    Levack, Daniel J. H.

    2000-01-01

    The objective of this contract was to provide definition of alternate propulsion systems for both earth-to-orbit (ETO) and in-space vehicles (upper stages and space transfer vehicles). For such propulsion systems, technical data to describe performance, weight, dimensions, etc. was provided along with programmatic information such as cost, schedule, needed facilities, etc. Advanced technology and advanced development needs were determined and provided. This volume separately presents the various program cost estimates that were generated under three tasks: the F- IA Restart Task, the J-2S Restart Task, and the SSME Upper Stage Use Task. The conclusions, technical results , and the program cost estimates are described in more detail in Volume I - Executive Summary and in individual Final Task Reports.

  11. A study of some recent advances in the concept and design of MHD generators

    International Nuclear Information System (INIS)

    Vakilian, M.

    1976-02-01

    Direct conversion of energy and high temperature working fluid making Magnetohydrodynamics (MHD) power plants potentially much more efficient than steam power stations. The study indicates an overall efficiency of 50% to 60%. This compares with most modern fossil-fuel plants at 40% efficiency. Advances in design and construction of experimental and commercial MHD plants developed in various countries are presented. Environmental effects and advantages of the MHD power plants over the more conventional fossil and nuclear plants are discussed

  12. Advanced steam power plant concepts with optimized life-cycle costs: A new approach for maximum customer benefit

    Energy Technology Data Exchange (ETDEWEB)

    Seiter, C.

    1998-07-01

    The use of coal power generation applications is currently enjoying a renaissance. New highly efficient and cost-effective plant concepts together with environmental protection technologies are the main factors in this development. In addition, coal is available on the world market at attractive prices and in many places it is more readily available than gas. At the economical leading edge, standard power plant concepts have been developed to meet the requirements of emerging power markets. These concepts incorporate the high technological state-of-the-art and are designed to achieve lowest life-cycle costs. Low capital cost, fuel costs and operating costs in combination with shortest lead times are the main assets that make these plants attractive especially for IPPs and Developers. Other aspects of these comprehensive concepts include turnkey construction and the willingness to participate in BOO/BOT projects. One of the various examples of such a concept, the 2 x 610-MW Paiton Private Power Project Phase II in Indonesia, is described in this paper. At the technological leading edge, Siemens has always made a major contribution and was pacemaker for new developments in steam power plant technology. Modern coal-fired steam power plants use computer-optimized process and plant design as well as advanced materials, and achieve efficiencies exceeding 45%. One excellent example of this high technology is the world's largest lignite-fired steam power plant Schwarze Pumpe in Germany, which is equipped with two 800 MW Siemens steam turbine generators with supercritical steam parameters. The world's largest 50-Hz single-shaft turbine generator with supercritical steam parameters rated at 1025 MW for the Niederaussem lignite-fired steam power plant in Germany is a further example of the sophisticated Siemens steam turbine technology and sets a new benchmark in this field.

  13. Space Station propulsion - Advanced development testing of the water electrolysis concept at MSFC

    Science.gov (United States)

    Jones, Lee W.; Bagdigian, Deborah R.

    1989-01-01

    The successful demonstration at Marshall Space Flight Center (MSFC) that the water electrolysis concept is sufficiently mature to warrant adopting it as the baseline propulsion design for Space Station Freedom is described. In particular, the test results demonstrated that oxygen/hydrogen thruster, using gaseous propellants, can deliver more than two million lbf-seconds of total impulse at mixture ratios of 3:1 to 8:1 without significant degradation. The results alao demonstrated succcessful end-to-end operation of an integrated water electrolysis propulsion system.

  14. Basic concept and its aims of E-journal of advanced maintenance

    International Nuclear Information System (INIS)

    Miya, Kenzo

    2009-01-01

    This article describes basic concept and aims of EJAM with history of effort to realize the launching of it. It took about three years until launching of the journal through approach to EPRI and negotiation with international publishing companies. It consists of three major articles. They are 1) general articles, 2) academic papers and 3) maintenance technique to be applied to repairing of components of nuclear power plants. All together of these articles may contribute to understanding of clear image of what maintenance is in this journal. Finally future image of this journal is described in light of maintenance evolution. (author)

  15. Advanced transportation system studies technical area 3: Alternate propulsion subsystem concepts, volume 2

    Science.gov (United States)

    Levak, Daniel

    1993-01-01

    The Alternate Propulsion Subsystem Concepts contract had five tasks defined for the first year. The tasks were: F-1A Restart Study, J-2S Restart Study, Propulsion Database Development, Space Shuttle Main Engine (SSME) Upper Stage Use, and CER's for Liquid Propellant Rocket Engines. The detailed study results, with the data to support the conclusions from various analyses, are being reported as a series of five separate Final Task Reports. Consequently, this volume only reports the required programmatic information concerning Computer Aided Design Documentation, and New Technology Reports. A detailed Executive Summary, covering all the tasks, is also available as Volume 1.

  16. Advances in nonlinear analysis via the concept of measure of noncompactness

    CERN Document Server

    Jleli, Mohamed; Mursaleen, Mohammad; Samet, Bessem; Vetro, Calogero

    2017-01-01

    This book offers a comprehensive treatment of the theory of measures of noncompactness. It discusses various applications of the theory of measures of noncompactness, in particular, by addressing the results and methods of fixed-point theory. The concept of a measure of noncompactness is very useful for the mathematical community working in nonlinear analysis. Both these theories are especially useful in investigations connected with differential equations, integral equations, functional integral equations and optimization theory. Thus, one of the book’s central goals is to collect and present sufficient conditions for the solvability of such equations. The results are established in miscellaneous function spaces, and particular attention is paid to fractional calculus.

  17. The dynomak: An advanced spheromak reactor concept with imposed-dynamo current drive and next-generation nuclear power technologies

    Energy Technology Data Exchange (ETDEWEB)

    Sutherland, D.A., E-mail: das1990@uw.edu; Jarboe, T.R.; Morgan, K.D.; Pfaff, M.; Lavine, E.S.; Kamikawa, Y.; Hughes, M.; Andrist, P.; Marklin, G.; Nelson, B.A.

    2014-04-15

    A high-β spheromak reactor concept has been formulated with an estimated overnight capital cost that is competitive with conventional power sources. This reactor concept utilizes recently discovered imposed-dynamo current drive (IDCD) and a molten salt (FLiBe) blanket system for first wall cooling, neutron moderation and tritium breeding. Currently available materials and ITER-developed cryogenic pumping systems were implemented in this concept from the basis of technological feasibility. A tritium breeding ratio (TBR) of greater than 1.1 has been calculated using a Monte Carlo N-Particle (MCNP5) neutron transport simulation. High temperature superconducting tapes (YBCO) were used for the equilibrium coil set, substantially reducing the recirculating power fraction when compared to previous spheromak reactor studies. Using zirconium hydride for neutron shielding, a limiting equilibrium coil lifetime of at least thirty full-power years has been achieved. The primary FLiBe loop was coupled to a supercritical carbon dioxide Brayton cycle due to attractive economics and high thermal efficiencies. With these advancements, an electrical output of 1000 MW from a thermal output of 2486 MW was achieved, yielding an overall plant efficiency of approximately 40%.

  18. Advancing Empirical Approaches to the Concept of Resilience: A Critical Examination of Panarchy, Ecological Information, and Statistical Evidence

    Directory of Open Access Journals (Sweden)

    Ali Kharrazi

    2016-09-01

    Full Text Available Despite its ambiguities, the concept of resilience is of critical importance to researchers, practitioners, and policy-makers in dealing with dynamic socio-ecological systems. In this paper, we critically examine the three empirical approaches of (i panarchy; (ii ecological information-based network analysis; and (iii statistical evidence of resilience to three criteria determined for achieving a comprehensive understanding and application of this concept. These criteria are the ability: (1 to reflect a system’s adaptability to shocks; (2 to integrate social and environmental dimensions; and (3 to evaluate system-level trade-offs. Our findings show that none of the three currently applied approaches are strong in handling all three criteria. Panarchy is strong in the first two criteria but has difficulty with normative trade-offs. The ecological information-based approach is strongest in evaluating trade-offs but relies on common dimensions that lead to over-simplifications in integrating the social and environmental dimensions. Statistical evidence provides suggestions that are simplest and easiest to act upon but are generally weak in all three criteria. This analysis confirms the value of these approaches in specific instances but also the need for further research in advancing empirical approaches to the concept of resilience.

  19. Safety physics inter-comparison of advanced concepts of critical reactors and ADS

    International Nuclear Information System (INIS)

    Slessarev, I.

    2001-01-01

    Enhanced safety based on the principle of the natural ''self-defence'' is one of the most desirable features of innovative nuclear systems (critical or sub-critical) regarding both TRU transmutation and ''clean'' energy producer concepts. For the evaluation of the ''self-defence'' domain, the method of the asymptotic reactivity balance has been generalised. The promising option of Hybrids systems (that use a symbiosis of fission and spallation in sub-critical cores) which could benefit the advantages of both Accelerated Driven Systems of the traditional type and regular critical systems, has been advocated. General features of Hybrid dynamics have been presented and analysed. It was demonstrated that an external neutron source of Hybrids can expand the inherent safety potential significantly. This analysis has been applied to assess the safety physics potential of innovative concepts for prospective nuclear power both for energy producers and for transmutation. It has been found, that safety enhancement goal defines a choice of sub-criticality of Hybrids. As for energy producers with Th-fuel cycle, a significant sub-criticality level is required due to a necessity of an improvement of neutronics together with safety enhancement task. (author)

  20. Accuracy Improvement Capability of Advanced Projectile Based on Course Correction Fuze Concept

    Directory of Open Access Journals (Sweden)

    Ahmed Elsaadany

    2014-01-01

    Full Text Available Improvement in terminal accuracy is an important objective for future artillery projectiles. Generally it is often associated with range extension. Various concepts and modifications are proposed to correct the range and drift of artillery projectile like course correction fuze. The course correction fuze concepts could provide an attractive and cost-effective solution for munitions accuracy improvement. In this paper, the trajectory correction has been obtained using two kinds of course correction modules, one is devoted to range correction (drag ring brake and the second is devoted to drift correction (canard based-correction fuze. The course correction modules have been characterized by aerodynamic computations and flight dynamic investigations in order to analyze the effects on deflection of the projectile aerodynamic parameters. The simulation results show that the impact accuracy of a conventional projectile using these course correction modules can be improved. The drag ring brake is found to be highly capable for range correction. The deploying of the drag brake in early stage of trajectory results in large range correction. The correction occasion time can be predefined depending on required correction of range. On the other hand, the canard based-correction fuze is found to have a higher effect on the projectile drift by modifying its roll rate. In addition, the canard extension induces a high-frequency incidence angle as canards reciprocate at the roll motion.

  1. Accuracy improvement capability of advanced projectile based on course correction fuze concept.

    Science.gov (United States)

    Elsaadany, Ahmed; Wen-jun, Yi

    2014-01-01

    Improvement in terminal accuracy is an important objective for future artillery projectiles. Generally it is often associated with range extension. Various concepts and modifications are proposed to correct the range and drift of artillery projectile like course correction fuze. The course correction fuze concepts could provide an attractive and cost-effective solution for munitions accuracy improvement. In this paper, the trajectory correction has been obtained using two kinds of course correction modules, one is devoted to range correction (drag ring brake) and the second is devoted to drift correction (canard based-correction fuze). The course correction modules have been characterized by aerodynamic computations and flight dynamic investigations in order to analyze the effects on deflection of the projectile aerodynamic parameters. The simulation results show that the impact accuracy of a conventional projectile using these course correction modules can be improved. The drag ring brake is found to be highly capable for range correction. The deploying of the drag brake in early stage of trajectory results in large range correction. The correction occasion time can be predefined depending on required correction of range. On the other hand, the canard based-correction fuze is found to have a higher effect on the projectile drift by modifying its roll rate. In addition, the canard extension induces a high-frequency incidence angle as canards reciprocate at the roll motion.

  2. Safety physics inter-comparison of advanced concepts of critical reactors and ADS

    Energy Technology Data Exchange (ETDEWEB)

    Slessarev, I. [CEA Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. d' Etudes des Reacteurs

    2001-07-01

    Enhanced safety based on the principle of the natural ''self-defence'' is one of the most desirable features of innovative nuclear systems (critical or sub-critical) regarding both TRU transmutation and ''clean'' energy producer concepts. For the evaluation of the ''self-defence'' domain, the method of the asymptotic reactivity balance has been generalised. The promising option of Hybrids systems (that use a symbiosis of fission and spallation in sub-critical cores) which could benefit the advantages of both Accelerated Driven Systems of the traditional type and regular critical systems, has been advocated. General features of Hybrid dynamics have been presented and analysed. It was demonstrated that an external neutron source of Hybrids can expand the inherent safety potential significantly. This analysis has been applied to assess the safety physics potential of innovative concepts for prospective nuclear power both for energy producers and for transmutation. It has been found, that safety enhancement goal defines a choice of sub-criticality of Hybrids. As for energy producers with Th-fuel cycle, a significant sub-criticality level is required due to a necessity of an improvement of neutronics together with safety enhancement task. (author)

  3. A Review of Significant Advances in Neutron Imaging from Conception to the Present

    Science.gov (United States)

    Brenizer, J. S.

    This review summarizes the history of neutron imaging with a focus on the significant events and technical advancements in neutron imaging methods, from the first radiograph to more recent imaging methods. A timeline is presented to illustrate the key accomplishments that advanced the neutron imaging technique. Only three years after the discovery of the neutron by English physicist James Chadwick in 1932, neutron imaging began with the work of Hartmut Kallmann and Ernst Kuhn in Berlin, Germany, from 1935-1944. Kallmann and Kuhn were awarded a joint US Patent issued in January 1940. Little progress was made until the mid-1950's when Thewlis utilized a neutron beam from the BEPO reactor at Harwell, marking the beginning of the application of neutron imaging to practical applications. As the film method was improved, imaging moved from a qualitative to a quantitative technique, with applications in industry and in nuclear fuels. Standards were developed to aid in the quantification of the neutron images and the facility's capabilities. The introduction of dynamic neutron imaging (initially called real-time neutron radiography and neutron television) in the late 1970's opened the door to new opportunities and new challenges. As the electronic imaging matured, the introduction of the CCD imaging devices and solid-state light intensifiers helped address some of these challenges. Development of improved imaging devices for the medical community has had a major impact on neutron imaging. Additionally, amorphous silicon sensors provided improvements in temporal resolution, while providing a reasonably large imaging area. The development of new neutron imaging sensors and the development of new neutron imaging techniques in the past decade has advanced the technique's ability to provide insight and understanding of problems that other non-destructive techniques could not provide. This rapid increase in capability and application would not have been possible without the

  4. Operational freight carrier planning basic concepts, optimization models and advanced memetic algorithms

    CERN Document Server

    Schönberger, Jörn

    2005-01-01

    The modern freight carrier business requires a sophisticated automatic decision support in order to ensure the efficiency and reliability and therefore the survival of transport service providers. This book addresses these challenges and provides generic decision models for the short-term operations planning as well as advanced metaheuristics to obtain efficient operation plans. After a thorough analysis of the operations planning in the freight carrier business, decision models are derived. Their suitability is proven within a large number of numerical experiments, in which a new class of hybrid genetic search approaches demonstrate their appropriateness.

  5. Electric vehicle traction motors - The development of an advanced motor concept

    Science.gov (United States)

    Campbell, P.

    1980-01-01

    An axial-field permanent magnet traction motor is described, similar to several advanced motors that are being developed in the United States. This type of machine has several advantages over conventional dc motors, particularly in the electric vehicle application. The rapidly changing cost of magnetic materials, particularly cobalt, makes it important to study the utilization of permanent magnet materials in such machines. The impact of different magnets on machine design is evaluated, and the advantages of using iron powder composites in the armature are assessed.

  6. Advanced Concepts and Controversies in Emergency Department Pain Management.

    Science.gov (United States)

    Motov, Sergey M; Nelson, Lewis S

    2016-06-01

    Pain is the most common complaint for which patients come to the emergency department (ED). Emergency physicians are responsible for pain relief in a timely, efficient, and safe manner in the ED. The improvement in our understanding of the neurobiology of pain has balanced the utilization of nonopioid and opioid analgesia, and simultaneously has led to more rational and safer opioid prescribing practices. This article reviews advances in pain management in the ED for patients with acute and chronic pain as well as describes several newer strategies and controversies. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. The effects of advanced digital signal processing concepts on VLSIC/VHSIC design

    Science.gov (United States)

    Jankowski, C.

    Implementations of sophisticated mathematical techniques in advanced digital signal processors can significantly improve performance. Future VLSI and VHSI circuit designs must include the practical realization of these algorithms. A structured design approach is described and illustrated with examples from a RNS FIR filter processor development project. The CAE hardware and software required to support tasks of this complexity are also discussed. An EWS is recommended for controlling essential functions such as logic optimization, simulation and verification. The total IC design system is illustrated with the implementation of a new high performance algorithm for computing complex magnitude.

  8. African Cultural Concept of Death and the Idea of Advance Care Directives

    OpenAIRE

    Ekore, Rabi Ilemona; Lanre-Abass, Bolatito

    2016-01-01

    An advance care directive is a person's oral or written instructions about his or her future medical care, if he or she becomes unable to communicate. It may be in written or oral form. Africans ordinarily do not encourage the contemplation of death or any discussion about their own or their loved ones? death. According to the African belief system, life does not end with death, but continues in another realm. Becoming an ancestor after death is a desirable goal of every individual, a feat wh...

  9. Subsonic Ultra Green Aircraft Research Phase II: N+4 Advanced Concept Development

    Science.gov (United States)

    Bradley, Marty K.; Droney, Christopher K.

    2012-01-01

    This final report documents the work of the Boeing Subsonic Ultra Green Aircraft Research (SUGAR) team on Task 1 of the Phase II effort. The team consisted of Boeing Research and Technology, Boeing Commercial Airplanes, General Electric, and Georgia Tech. Using a quantitative workshop process, the following technologies, appropriate to aircraft operational in the N+4 2040 timeframe, were identified: Liquefied Natural Gas (LNG), Hydrogen, fuel cell hybrids, battery electric hybrids, Low Energy Nuclear (LENR), boundary layer ingestion propulsion (BLI), unducted fans and advanced propellers, and combinations. Technology development plans were developed.

  10. CTL epitope distribution patterns in the Gag and Nef proteins of HIV-1 from subtype A infected subjects in Kenya: Use of multiple peptide sets increases the detectable breadth of the CTL response

    Directory of Open Access Journals (Sweden)

    Birx Deborah L

    2006-04-01

    Full Text Available Abstract Background Subtype A is a major strain in the HIV-1 pandemic in eastern Europe, central Asia and in certain regions of east Africa, notably in rural Kenya. While considerable effort has been focused upon mapping and defining immunodominant CTL epitopes in HIV-1 subtype B and subtype C infections, few epitope mapping studies have focused upon subtype A. Results We have used the IFN-γ ELIspot assay and overlapping peptide pools to show that the pattern of CTL recognition of the Gag and Nef proteins in subtype A infection is similar to that seen in subtypes B and C. The p17 and p24 proteins of Gag and the central conserved region of Nef were targeted by CTL from HIV-1-infected Kenyans. Several epitope/HLA associations commonly seen in subtype B and C infection were also observed in subtype A infections. Notably, an immunodominant HLA-C restricted epitope (Gag 296–304; YL9 was observed, with 8/9 HLA-CW0304 subjects responding to this epitope. Screening the cohort with peptide sets representing subtypes A, C and D (the three most prevalent HIV-1 subtypes in east Africa, revealed that peptide sets based upon an homologous subtype (either isolate or consensus only marginally improved the capacity to detect CTL responses. While the different peptide sets detected a similar number of responses (particularly in the Gag protein, each set was capable of detecting unique responses not identified with the other peptide sets. Conclusion Hence, screening with multiple peptide sets representing different sequences, and by extension different epitope variants, can increase the detectable breadth of the HIV-1-specific CTL response. Interpreting the true extent of cross-reactivity may be hampered by the use of 15-mer peptides at a single concentration and a lack of knowledge of the sequence that primed any given CTL response. Therefore, reagent choice and knowledge of the exact sequences that prime CTL responses will be important factors in

  11. Advances in the delivery of RNA therapeutics: from concept to clinical reality.

    Science.gov (United States)

    Kaczmarek, James C; Kowalski, Piotr S; Anderson, Daniel G

    2017-06-27

    The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression of disease-relevant genes. RNA-based drugs, including short interfering RNAs and antisense oligonucleotides, are particularly promising examples of this newer class of biologics. For over two decades, researchers have been trying to overcome major challenges for utilizing such RNAs in a therapeutic context, including intracellular delivery, stability, and immune response activation. This research is finally beginning to bear fruit as the first RNA drugs gain FDA approval and more advance to the final phases of clinical trials. Furthermore, the recent advent of CRISPR, an RNA-guided gene-editing technology, as well as new strides in the delivery of messenger RNA transcribed in vitro, have triggered a major expansion of the RNA-therapeutics field. In this review, we discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies, and present an overview of the applications of RNA-based drugs for modulation of gene/protein expression and genome editing that are currently being investigated both in the laboratory as well as in the clinic.

  12. Integrated Circuit Conception: A Wire Optimization Technic Reducing Interconnection Delay in Advanced Technology Nodes

    Directory of Open Access Journals (Sweden)

    Mohammed Darmi

    2017-10-01

    Full Text Available As we increasingly use advanced technology nodes to design integrated circuits (ICs, physical designers and electronic design automation (EDA providers are facing multiple challenges, firstly, to honor all physical constraints coming with cutting-edge technologies and, secondly, to achieve expected quality of results (QoR. An advanced technology should be able to bring better performances with minimum cost whatever the complexity. A high effort to develop out-of-the-box optimization techniques is more than needed. In this paper, we will introduce a new routing technique, with the objective to optimize timing, by only acting on routing topology, and without impacting the IC Area. In fact, the self-aligned double patterning (SADP technology offers an important difference on layer resistance between SADP and No-SADP layers; this property will be taken as an advantage to drive the global router to use No-SADP less resistive layers for critical nets. To prove the benefit on real test cases, we will use Mentor Graphics’ physical design EDA tool Nitro-SoC™ and several 7 nm technology node designs. The experiments show that worst negative slack (WNS and total negative slack (TNS improved up to 13% and 56%, respectively, compared to the baseline flow.

  13. Selected advanced aerodynamics and active controls technology concepts development on a derivative B-747

    Science.gov (United States)

    1980-01-01

    The feasibility of applying wing tip extensions, winglets, and active control wing load alleviation to the Boeing 747 is investigated. Winglet aerodynamic design methods and high speed wind tunnel test results of winglets and of symmetrically deflected ailerons are presented. Structural resizing analyses to determine weight and aeroelastic twist increments for all the concepts and flutter model test results for the wing with winglets are included. Control law development, system mechanization/reliability studies, and aileron balance tab trade studies for active wing load alleviation systems are discussed. Results are presented in the form of incremental effects on L/D, structural weight, block fuel savings, stability and control, airplane price, and airline operating economics.

  14. Advanced Concepts for Ultrahigh Brightness and Low Temperature Beams. Final Report

    International Nuclear Information System (INIS)

    Wurtele, Jonathan S.; Fajans, Joel

    2015-01-01

    This grant supported research on techniques to manipulate and combine positrons and antiprotons to synthesize, and to probe, antihydrogen. The majority of the research was conducted as part of the ALPHA Collaboration at CERN. Using ideas and techniques from accelerator physics, we proposed a new method for measuring the the gravitational attraction of antihydrogen to the Earth's field. ALPHA reported the first precision charge measurement on antihydrogen and a crude bound on its gravitational dynamics in the Earth's field. We proposed using a stochastic acceleration method to measure any putative charge of antihydrogen and built numerical models of the mixing of antiprotons and positrons. Further research included proposing the radiator-first concept for operating an X-ray free electron laser driven by a high repetition rate bunch source and studying scattering in passive foil-based ion focusing systems.

  15. Advanced Concepts for Ultrahigh Brightness and Low Temperature Beams. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Wurtele, Jonathan S. [Univ. of California, Berkeley, CA (United States); Fajans, Joel [Univ. of California, Berkeley, CA (United States)

    2015-06-01

    This grant supported research on techniques to manipulate and combine positrons and antiprotons to synthesize, and to probe, antihydrogen. The majority of the research was conducted as part of the ALPHA Collaboration at CERN. Using ideas and techniques from accelerator physics, we proposed a new method for measuring the the gravitational attraction of antihydrogen to the Earth's field. ALPHA reported the first precision charge measurement on antihydrogen and a crude bound on its gravitational dynamics in the Earth's field. We proposed using a stochastic acceleration method to measure any putative charge of antihydrogen and built numerical models of the mixing of antiprotons and positrons. Further research included proposing the radiator-first concept for operating an X-ray free electron laser driven by a high repetition rate bunch source and studying scattering in passive foil-based ion focusing systems.

  16. Diesel engine exhaust gas recirculation--a review on advanced and novel concepts

    Energy Technology Data Exchange (ETDEWEB)

    Zheng Ming E-mail: mzheng@uwindsor.ca; Reader, Graham T.; Hawley, J. Gary

    2004-04-01

    Exhaust gas recirculation (EGR) is effective to reduce nitrogen oxides (NO{sub x}) from Diesel engines because it lowers the flame temperature and the oxygen concentration of the working fluid in the combustion chamber. However, as NO{sub x} reduces, particulate matter (PM) increases, resulting from the lowered oxygen concentration. When EGR further increases, the engine operation reaches zones with higher instabilities, increased carbonaceous emissions and even power losses. In this research, the paths and limits to reduce NO{sub x} emissions from Diesel engines are briefly reviewed, and the inevitable uses of EGR are highlighted. The impact of EGR on Diesel operations is analyzed and a variety of ways to implement EGR are outlined. Thereafter, new concepts regarding EGR stream treatment and EGR hydrogen reforming are proposed.

  17. Advanced limiter test (ALT-I) in the TEXTOR tokamak - concept and experimental design

    International Nuclear Information System (INIS)

    Conn, R.W.; Grotz, S.P.; Prinja, A.K.

    1983-01-01

    The concept and experimental design of a pump-limiter for the TEXTOR tokamak is described. The module is constructed of stainless steel with a compound curvature head designed to limit the maximum heat flux to 300 W/cm 2 . The head is made of TiC-coated graphite containing a variable aperture slot to admit plasma to a deflector plate for ballistic pumping action. The assembly is actively pumped using Zr-Al getters with an estimated hydrogen pumping speed of 2x10 4 1/s. The aspect ratio of the pump duct and the length of the plasma channel are both variable to permit study of plasma plugging, ballistic scattering, and enhanced gas conduction effects. The module can be moved radially by 10 cm to permit its operation either as the primary or secondary limiter. Major diagnostics include Langmuir and solid state probes, bolometers, infrared thermography, thermocouples, ion gauges, manometers, and a gas mass analyzer. (author)

  18. Palliative radiotherapy. Ranking within an interdisciplinary treatment concept in case of advanced tumor disease

    International Nuclear Information System (INIS)

    Seegenschmiedt, M.H.

    1998-01-01

    Many tumor-induced symptoms can be alleviated by suitable irradiation in a direct, effective and sparing manner. The clinical response amounts to 80% and is independent of tumor histology. Careful diagnosis and accurate localisation of the causes of symptoms as well as exact therapy planning and execution are required. Based on individual dose planning harmonising single dosis and total dosis, pin-pointed definition of target areas, and application of modern planning and irradiation techniques, palliative radiotherapy is able to achieve long-term improvement with neglectible side-effects, sometimes within only a few days or weeks. It is a valuable part of a consistant therapy concept that is tailored to the individual needs of a patient, by cooperative action of experts from a variety of medical disciplines, intended to optimize the quality of life of patients, and sometimes may exclude conventional radiotherapy. (orig./CB) [de

  19. Leukocyte function-associated antigen-1-dependent lysis of Fas+ (CD95+/Apo-1+) innocent bystanders by antigen-specific CD8+ CTL.

    Science.gov (United States)

    Kojima, H; Eshima, K; Takayama, H; Sitkovsky, M V

    1997-09-15

    Exquisite specificity toward Ag-bearing cells (cognate targets) is one of the most important properties of CD8+ CTL-mediated cytotoxicity. Using highly Ag-specific CD8+ CTL lines and clones, which spare noncognate, Ag-free targets, we found that in the presence of Ag-bearing targets the CTL acquire the ability to lyse noncognate target cells (bystanders). It is shown that the unexpectedly rapid and efficient lysis of bystanders by Ag-activated CTL is mediated by a Fas ligand (FasL)/Fas-based mechanism and does not depend on perforin. The CTL lysed Fas-expressing bystanders, but spared the Fas-negative or anti-Fas mAb-resistant bystander cells. Accordingly, the FasL-deficient gld/gld CTL did not kill bystanders, while perforin-deficient CTL did. Unlike anti-Fas mAb-induced cell death, the lysis of bystanders was not only FasL/Fas dependent but also required adhesion molecule LFA-1 on the surface of the activated CTL. Lysis of bystanders is viewed as acceptable "collateral" damage, but the persistent presence of activated CTL could result in immunopathologies involving functional Fas-expressing tissues.

  20. Advances in intelligent process-aware information systems concepts, methods, and technologies

    CERN Document Server

    Oberhauser, Roy; Reichert, Manfred

    2017-01-01

    This book provides a state-of-the-art perspective on intelligent process-aware information systems and presents chapters on specific facets and approaches applicable to such systems. Further, it highlights novel advances and developments in various aspects of intelligent process-aware information systems and business process management systems. Intelligence capabilities are increasingly being integrated into or created in many of today’s software products and services. Process-aware information systems provide critical computing infrastructure to support the various processes involved in the creation and delivery of business products and services. Yet the integration of intelligence capabilities into process-aware information systems is a non-trivial yet necessary evolution of these complex systems. The book’s individual chapters address adaptive process management, case management processes, autonomically-capable processes, process-oriented information logistics, process recommendations, reasoning over ...

  1. Development of selected advanced aerodynamics and active control concepts for commercial transport aircraft

    Science.gov (United States)

    Taylor, A. B.

    1984-01-01

    Work done under the Energy Efficient Transport project in the field of advanced aerodynamics and active controls is summarized. The project task selections focused on the following: the investigation of long-duct nacelle shape variation on interference drag; the investigation of the adequacy of a simple control law for the elastic modes of a wing; the development of the aerodynamic technology at cruise and low speed of high-aspect-ratio supercritical wings of high performance; and the development of winglets for a second-generation jet transport. All the tasks involved analysis and substantial wind tunnel testing. The winglet program also included flight evaluation. It is considered that the technology base has been built for the application of high-aspect-ratio supercritical wings and for the use of winglets on second-generation transports.

  2. Dynamics of a viral infection model with delayed CTL response and immune circadian rhythm

    International Nuclear Information System (INIS)

    Bai Zhenguo; Zhou Yicang

    2012-01-01

    This paper studies the global dynamics of a viral infection model that takes into account circadian rhythm and time delay in the CTL response. It is shown that the basic reproduction numbers, R 0 and R 1 , determine the outcome of viral infection. Numerical simulations demonstrate that the changes in the amplitude of lytic component can generate a variety of dynamical patterns, ranging from simple daily oscillation to multi-day dynamics and eventually chaos, whereas time delay can alter the period of oscillation for the larger level of periodic forcing. These results can help to explain the viral oscillation behaviors, which were observed in chronic HBV and HCV infection patients.

  3. Endoplasmic reticulum targeting sequence enhances HBV-specific cytotoxic T lymphocytes induced by a CTL epitope-based DNA vaccine

    International Nuclear Information System (INIS)

    Xu Wei; Chu Yiwei; Zhang Ruihua; Xu Huanbin; Wang Ying; Xiong Sidong

    2005-01-01

    CD8 + T cells play a critical role in protective immunity against Hepatitis B Virus (HBV). Epitope-based DNA vaccines expressing HBV-dominant CTL epitopes can be used as candidate vaccines capable of inducing cytotoxic T Lymphocytes (CTL) responses. A plasmid DNA encoding a CTL epitope of HBV core antigen, HBc 18-27 , was constructed. Intramuscular immunization of C57BL/6 mice with this DNA vaccine resulted in successful induction of HBV-specific CTL responses. In order to promote transportation of the peptide into endoplasmic reticulum (ER) to bind to MHC class I molecules for optimal class I antigen presentation, an ER targeting sequence (ERTS) was fused with the C 18-27 encoding gene. ERTS fusion significantly enhanced specific CD8 + T cell responses in terms of CTL cytolysis as well as IFN-γ secretion. This enhancement was correlated with promoted epitope presentation on target cell surface. We report here an enhanced immunogenicity of an epitope-based DNA vaccine using an ER targeting signal sequence, which has significant implications for future design of therapeutic HBV vaccine

  4. Computer-assisted generation of individual training concepts for advanced education in manufacturing metrology

    International Nuclear Information System (INIS)

    Werner, Teresa; Weckenmann, Albert

    2010-01-01

    Due to increasing requirements on the accuracy and reproducibility of measurement results together with a rapid development of novel technologies for the execution of measurements, there is a high demand for adequately qualified metrologists. Accordingly, a variety of training offers are provided by machine manufacturers, universities and other institutions. Yet, for an interested learner it is very difficult to define an optimal training schedule for his/her individual demands. Therefore, a computer-based assistance tool is developed to support a demand-responsive scheduling of training. Based on the difference between the actual and intended competence profile and under consideration of amending requirements, an optimally customized qualification concept is derived. For this, available training offers are categorized according to different dimensions: regarding contents of the course, but also intended target groups, focus of the imparted competences, implemented methods of learning and teaching, expected constraints for learning and necessary preknowledge. After completing a course, the achieved competences and the transferability of gathered knowledge are evaluated. Based on the results, recommendations for amending measures of learning are provided. Thus, a customized qualification for manufacturing metrology is facilitated, adapted to the specific needs and constraints of each individual learner

  5. Practical applications of safety culture concepts in human performance advances on Russian nuclear industry

    International Nuclear Information System (INIS)

    Abramova, V.N.; Volkov, E.V.; Gordienko, O.V.; Melnitskaya, T.B.; Volkova, I.V.; Alexeev, G.A.

    2002-01-01

    Sometimes, many from negative external factors can be compensated by human psychological readiness of worker. However there would be main worse to come: some cases of personnel activity and organisational factors, some person's peculiarities (attitudes, responsibility, etc.) add considerable number of the events at NPPs. A lot of aspects of Human Factor Reliability are united in Safety Culture concept. This paper presents some results of our recently research in that area. In 'proactive approach': Unique methods for measuring maturity and satisfaction of personnel motivation: comparative analysis of the labour and safety culture motivation from attitude; organization of the socio-psychological climate and safety attitude examining monitoring at all of Russia's NPPs; working-out recommendations for managers on improving human performance are presented. Besides, ergonomic research concerning work conditions at the NPP is displayed. In 'reactive approach': Analysis of the incorrect activity cases, which led to the breaches of work of the Russian NPPs, is shown. The special method to work-up is used. It was issue, that events caused by a human error, depends not only on the worker's professional competence, but on the attitude and motivation, some professionally important psychological and psycho-physiological quality data, the functional state, the group's socio-psychological climate, etc. (author)

  6. Micro-structured nuclear fuel and novel nuclear reactor concepts for advanced power production

    International Nuclear Information System (INIS)

    Popa-Simil, Liviu

    2008-01-01

    Many applications (e.g. terrestrial and space electric power production, naval, underwater and railroad propulsion and auxiliary power for isolated regions) require a compact-high-power electricity source. The development of such a reactor structure necessitates a deeper understanding of fission energy transport and materials behavior in radiation dominated structures. One solution to reduce the greenhouse-gas emissions and delay the catastrophic events' occurrences may be the development of massive nuclear power. The actual basic conceptions in nuclear reactors are at the base of the bottleneck in enhancements. The current nuclear reactors look like high security prisons applied to fission products. The micro-bead heterogeneous fuel mesh gives the fission products the possibility to acquire stable conditions outside the hot zones without spilling, in exchange for advantages - possibility of enhancing the nuclear technology for power production. There is a possibility to accommodate the materials and structures with the phenomenon of interest, the high temperature fission products free fuel with near perfect burning. This feature is important to the future of nuclear power development in order to avoid the nuclear fuel peak, and high price increase due to the immobilization of the fuel in the waste fuel nuclear reactor pools. (author)

  7. Advanced core concepts with enhanced proliferation resistance by transmutation of minor actinides

    International Nuclear Information System (INIS)

    Saito, Masaki

    2005-01-01

    ''Protected Plutonium Production (P 3 )'' has been proposed to establish high burn-up cores and to produce protected with high proliferation resistance due to high decay heat and large number of spontaneous fission neutron of 238 Pu by the transmutation of Minor Actinides (MAs) which is presently treated as high-level waste. The burn-up calculations have shown that the advanced fuel with UO 2 (11-13% enrichment of 235 U) by doping 237 Np to produce 238 Pu in the commercialized large LWRs burn up to 100 GWd/t with 238 Pu to Pu ratio of about 20% which means the fuel is highly protected from proliferation. It was also predicted that medium or small size LWR cores with 15-17% enrichment, liquid metal cooled cores, and gas cooled cores added by 1-2% Np could achieve 100 GWd/t burning with bearing high proliferation resistance. The 237 Np mass balance calculations have revealed that more than 20 nuclear P 3 plants of 300 MWe could be supplied with enough 237 Np from the Japanese commercial plants in equilibrium fuel cycles. From the present studies, it is confirmed that MAs are treated as burnable and fertile materials not only to extend the core life but also to improve plutonium proliferation resistance of the future nuclear energy systems instead of their geological disposal or just their burning through fission. (author)

  8. Benefits associated with advanced technologies applied to a high-speed civil transport concept

    Science.gov (United States)

    Ozoroski, L. P.; Shields, E. W.; Fenbert, J. W.; Mcelroy, M. O.

    1993-01-01

    Results of a first-order assessment of the mission performance benefits associated with the technology improvements and goals of the Phase II High-Speed Research (HSR) Program are presented. A breakdown of the four major disciplines resulted in the following estimated TOGW savings from the 1990 vehicle: propulsion at 14.3 percent, structures at 11.7 percent, flight-deck systems at 4.0 percent, and aerodynamics at 15.0 percent. Based on 100 percent success of the HSR Phase II proposed technology advancements, the overall combined impact is estimated to result in a 45 percent reduction in TOGW from a 1990 entry-into-service (EIS) date, which could result in a viable 2005 EIS vehicle with an acceptable TOGW that meets Stage III community noise restrictions. Through supersonic laminar flow control and the possible reduction in reserve fuel requirements resulting from synthetic vision capability, the potential exists for an additional 9.6 percent reduction in TOGW.

  9. A nuclear powered pulsed inductive plasma accelerator as a viable propulsion concept for advanced OTV space applications

    International Nuclear Information System (INIS)

    Tapper, M.L.

    1982-01-01

    An electric propulsion concept suitable for delivering heavy payloads from low earth orbit (LEO) to high energy earth orbit is proposed. The system consists of a number of pulsed inductive plasma thrusters powered by a 100 kWe space nuclear power system. The pulsed plasma thruster is a relatively simple electrodeless device. It also exhibits adequate conversion to thrust power in the desired I sub sp regime of 1500 to 3000 seconds for optimal payload transfer from low earth to high earth orbit. Because of these features and the fact that the nuclear power unit will be capable of delivering sustained high power levels throughout the duration of any given mission, the system presented appears to be a very promising propulsion candidate for advanced orbital transfer vehicle (OTV) applications. An OTV, which makes use of this propulsion system and which has been designed to lift a 9000-lb payload into geosynchronous earth orbit, (GEO) is also examined

  10. US long distance fiber optic networks: Technology, evolution and advanced concepts. Volume 2: Fiber optic technology and long distance networks

    Science.gov (United States)

    1986-10-01

    The study projects until 2000 the evolution of long distance fiber optic networks in the U.S. Volume 1 is the Executive Summary. Volume 2 focuses on fiber optic components and systems that are directly related to the operation of long-haul networks. Optimistic, pessimistic and most likely scenarios of technology development are presented. The activities of national and regional companies implementing fiber long haul networks are also highlighted, along with an analysis of the market and regulatory forces affecting network evolution. Volume 3 presents advanced fiber optic network concept definitions. Inter-LATA traffic is quantified and forms the basis for the construction of 11-, 15-, 17-, and 23-node networks. Using the technology projections from Volume 2, a financial model identifies cost drivers and determines circuit mile costs between any two LATAs. A comparison of fiber optics with alternative transmission concludes the report.

  11. Feasibility and Safety Assessment for Advanced Reactor Concepts Using Vented Fuel

    International Nuclear Information System (INIS)

    Klein, Andrew; Lenhof, Renae; Deason, Wesley; Harter, Jackson

    2015-01-01

    Recent interest in fast reactor technology has led to renewed analysis of past reactor concepts such as Gas Fast Reactors and Sodium Fast Reactors. In an effort to make these reactors more economic, the fuel is required to stay in the reactor for extended periods of time; the longer the fuel stays within the core, the more fertile material is converted into usable fissile material. However, as burnup of the fuel-rod increases, so does the internal pressure buildup due to gaseous fission products. In order to reach the 30 year lifetime requirements of some reactor designs, the fuel pins must have a vented-type design to allow the buildup of fission products to escape. The present work aims to progress the understanding of the feasibility and safety issues related to gas reactors that incorporate vented fuel. The work was separated into three different work-scopes: 1. Quantitatively determine fission gas release from uranium carbide in a representative helium cooled fast reactor; 2. Model the fission gas behavior, transport, and collection in a Fission Product Vent System; and, 3. Perform a safety analysis of the Fission Product Vent System. Each task relied on results from the previous task, culminating in a limited scope Probabilistic Risk Assessment (PRA) of the Fission Product Vent System. Within each task, many key parameters lack the fidelity needed for comprehensive or accurate analysis. In the process of completing each task, the data or methods that were lacking were identified and compiled in a Gap Analysis included at the end of the report.

  12. Microbial ecology in the age of genomics and metagenomics: concepts, tools, and recent advances.

    Science.gov (United States)

    Xu, Jianping

    2006-06-01

    Microbial ecology examines the diversity and activity of micro-organisms in Earth's biosphere. In the last 20 years, the application of genomics tools have revolutionized microbial ecological studies and drastically expanded our view on the previously underappreciated microbial world. This review first introduces the basic concepts in microbial ecology and the main genomics methods that have been used to examine natural microbial populations and communities. In the ensuing three specific sections, the applications of the genomics in microbial ecological research are highlighted. The first describes the widespread application of multilocus sequence typing and representational difference analysis in studying genetic variation within microbial species. Such investigations have identified that migration, horizontal gene transfer and recombination are common in natural microbial populations and that microbial strains can be highly variable in genome size and gene content. The second section highlights and summarizes the use of four specific genomics methods (phylogenetic analysis of ribosomal RNA, DNA-DNA re-association kinetics, metagenomics, and micro-arrays) in analysing the diversity and potential activity of microbial populations and communities from a variety of terrestrial and aquatic environments. Such analyses have identified many unexpected phylogenetic lineages in viruses, bacteria, archaea, and microbial eukaryotes. Functional analyses of environmental DNA also revealed highly prevalent, but previously unknown, metabolic processes in natural microbial communities. In the third section, the ecological implications of sequenced microbial genomes are briefly discussed. Comparative analyses of prokaryotic genomic sequences suggest the importance of ecology in determining microbial genome size and gene content. The significant variability in genome size and gene content among strains and species of prokaryotes indicate the highly fluid nature of prokaryotic

  13. [The Research Advancement and Conception of the Deep-underground Medicine].

    Science.gov (United States)

    Xie, He-Ping; Liu, Ji-Feng; Gao, Ming-Zhong; Wan, Xue-Hong; Liu, Shi-Xi; Zou, Jian; Wu, Jiang; Ma, Teng-Fei; Liu, Yi-Lin; Bu, Hong; Li, Wei-Min

    2018-03-01

    The 21th century is the century of exploring and utilizing the underground space. In the future, more and more people will spend more and more time living or/and working in the underground space. However,we know little about the effect on the health of human caused by the underground environment. Herein,we systematically put forward the strategic conception of the deep-underground medicine,in order to reveal relative effects and mechanism of the potential factors in the deep underground space on human's physiological and psychological healthy,and to work out the corresponding countermeasures. The original deep-underground medicine includes the following items. ①To model different depth of underground environment according to various parameters (such as temperature,radiation,air pressure, rock,microorganism), and to explore their quantitative character and effects on human health and mechanism. ② To study the psychological change, maintenance of homeostasis and biothythm of organism in the deep underground space. ③ To learn the association between psychological healthy of human and the depth, structure, physical environment and working time of underground space. ④ To investigate the effect of different terrane and lithology on healthy of human and to deliberate their contribution on organism growth. ⑤ To research the character and their mechanism of growth,metabolism,exchange of energy,response of growth, aging and adaptation of cells living in deep underground space. ⑥ To explore the physiological feature,growth of microbiome and it's interaction with host in the deep underground space. ⑦ To develop deep-underground simulation space, the biologically medical technology and equipments. As a research basis,a deep-underground medical lab under a rock thickness of about 1 470 m has been built,which aims to operate the research of the effect on living organism caused by different depth of underground environment. Copyright© by Editorial Board of Journal

  14. Feasibility and Safety Assessment for Advanced Reactor Concepts Using Vented Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Andrew [Oregon State Univ., Corvallis, OR (United States). Nuclear Engineering and Radiation Health Physics; Matthews, Topher [Oregon State Univ., Corvallis, OR (United States); Lenhof, Renae [Oregon State Univ., Corvallis, OR (United States); Deason, Wesley [Oregon State Univ., Corvallis, OR (United States); Harter, Jackson [Oregon State Univ., Corvallis, OR (United States)

    2015-01-16

    Recent interest in fast reactor technology has led to renewed analysis of past reactor concepts such as Gas Fast Reactors and Sodium Fast Reactors. In an effort to make these reactors more economic, the fuel is required to stay in the reactor for extended periods of time; the longer the fuel stays within the core, the more fertile material is converted into usable fissile material. However, as burnup of the fuel-rod increases, so does the internal pressure buildup due to gaseous fission products. In order to reach the 30 year lifetime requirements of some reactor designs, the fuel pins must have a vented-type design to allow the buildup of fission products to escape. The present work aims to progress the understanding of the feasibility and safety issues related to gas reactors that incorporate vented fuel. The work was separated into three different work-scopes: 1. Quantitatively determine fission gas release from uranium carbide in a representative helium cooled fast reactor; 2. Model the fission gas behavior, transport, and collection in a Fission Product Vent System; and, 3. Perform a safety analysis of the Fission Product Vent System. Each task relied on results from the previous task, culminating in a limited scope Probabilistic Risk Assessment (PRA) of the Fission Product Vent System. Within each task, many key parameters lack the fidelity needed for comprehensive or accurate analysis. In the process of completing each task, the data or methods that were lacking were identified and compiled in a Gap Analysis included at the end of the report.

  15. Quantum Mechanics: Fundamentals; Advanced Quantum Mechanics; Mathematical Concepts of Quantum Mechanics

    International Nuclear Information System (INIS)

    Whitaker, A

    2004-01-01

    second book under consideration, that of Schwabl, contains 'Advanced' elements of quantum theory; it is designed for a course following on from one for which Gottfried and Yan, or Schwabl's own 'Quantum Mechanics' might be recommended. Many useful student problems are included. The presentation is said to be rigorous, but again this is a book for the physicist rather than the mathematician. The third book under consideration, that by Gustafson and Sigal is very different from the others. In academic level, at least the initial sections may actually be slightly lower; the book covers a one-term course taken by senior undergraduates or junior graduate students in mathematics or physics, and the initial chapters are on basic topics, such as the physical background, basic dynamics, observables and the uncertainty principle. However the level of mathematical sophistication is far higher than in the other books. While the mathematical prerequisites are modest, a third of the book is made up of what are called mathematical supplements. On the basis of these supplements, the level of mathematical sophistication and difficulty is increased substantially in the middle section of the book, where the topics considered are many-particle systems, density matrices, positive temperatures, the Feynman path integral, and quasi-classical analysis, and there is a final substantial step for the concluding chapters on resonances, an introduction to quantum field theory, and quantum electrodynamics of non-relativistic particles. A supplementary chapter contains an interesting approach to the renormalization group due to Bach, Froehlich and Sigal himself. This book is well-written, and the topics discussed have been well thought-out. It would provide a useful approach to quantum theory for the mathematician, and would also provide access for the physicist to some mathematically advanced methods and topics, but the physicist would definitely have to be prepared to work hard at the mathematics

  16. Development of a test bed for operator aid and advanced control concepts in nuclear power plants

    International Nuclear Information System (INIS)

    Turinsky, P.J.; Doster, J.M.; Kim, K.D.; Al-Chalabi, R.M.; Khedro, T.; Sues, R.H.; Yacout, A.M.

    1990-01-01

    A great amount of research and development is currently under way in the utilization of artificial intelligence (AI), expert system, and control theory advances in nuclear power plants as a basis for operator aids and automatic control systems. This activity requires access to the measured dynamic responses of the plant to malfunction, operator- or automatic-control-initiated actions. This can be achieved by either simulating plant behavior or by using an actual plant. The advantage of utilizing an actual plant versus a simulator is that the true behavior is assured of both the power generation system and instrumentation. Clearly, the disadvantages of using an actual plant are availability due to licensing, economic, and risk constraints and inability to address accident conditions. In this work the authors have decided to employ a functional one-ninth scale model of a pressurized water reactor (PWR). The scaled PWR (SPWR) facility is a two-loop representation of a Westinghouse PWR utilizing freon as the working fluid and electric heater rods for the core. The heater rods are driven by a neutron kinetics model accounting for measured thermal core conditions. A control valve in the main steam line takes the place of the turbine generator. A range of normal operating and accident situations can be addressed. The SPWR comes close to offering all the advantages of both a simulator and an actual physical plant in regard to research and development on AI, expert system, and control theory applications. The SPWR is being employed in the development of an expert-system-based operator aid system. The current status of this project is described

  17. Driving forces and barriers in the development and implementation of coal-to-liquids (CtL) technologies in Germany

    International Nuclear Information System (INIS)

    Vallentin, Daniel

    2008-01-01

    Because of a growing global energy demand and rising oil prices coal-abundant nations, such as China and the United States, are pursuing the application of technologies which could replace crude oil imports by converting coal to synthetic hydrocarbon fuels-so-called coal-to-liquids (CtL) technologies. The case of CtL is well suited to analyse techno-economic, resources-related, policy-driven and actor-related parameters, which are affecting the market prospects of a technology that eases energy security constraints but is hardly compatible with a progressive climate policy. This paper concentrates on Germany as an example-the European Union (EU)'s largest member state with considerable coal reserves. It shows that in Germany and the EU, CtL is facing rather unfavourable market conditions as high costs and ambitious climate targets offset its energy security advantage

  18. C-type lectin B (SpCTL-B) regulates the expression of antimicrobial peptides and promotes phagocytosis in mud crab Scylla paramamosain.

    Science.gov (United States)

    Wei, Xiaoyuan; Wang, Limin; Sun, Wanwei; Zhang, Ming; Ma, Hongyu; Zhang, Yueling; Zhang, Xinxu; Li, Shengkang

    2018-07-01

    As pattern recognition receptors, C-type lectins (CTLs) play important roles in immune system of crustaceans through identifying and binding to the conservative pathogen-associated molecular patterns (PAMPs) on pathogen surfaces. In this study, a new CTL, SpCTL-B, was identified from the hemocytes of mud crab Scylla paramamosain. The full-length of SpCTL-B cDNA was 1278 bp with an open reading frame (ORF) of 348 bp. The predicted SpCTL-B protein contains a single carbohydrate-recognition domain (CRD). SpCTL-B transcripts were distributed in all examined tissues with the highest levels in hepatopancreas. After challenged with Vibrio parahaemolyticus, LPS, polyI:C and white spot syndrome virus (WSSV), the mRNA levels of SpCTL-B in hemocytes and hepatopancreas were up-regulated. The recombinant SpCTL-B (rSpCTL-B) purified by Ni-affinity chromatography showed stronger binding activities with Staphylococcus aureus, β-hemolytic Streptococcus, Escherichia coli, Aeromonas hydrophila, Vibrio alginolyticus than those with V. parahaemolyticus and Saccharomyces cerevisiae. rSpCTL-B exhibited a broad spectrum of microorganism-agglutination activities against Gram-positive bacteria (S. aureus, β-hemolytic Streptococcus) and Gram-negative bacteria (E. coli, V. parahaemolyticus, A. hydrophila, V. alginolyticus) in a Ca 2+ -dependent manner. The agglutination activities of rSpCTL-B could be inhibited by D-mannose and LPS, but not by d-fructose and galactose. The antimicrobial assay showed that rSpCTL-B exhibited the growth inhibition against all examined gram-positive bacteria and gram-negative bacteria. When SpCTL-B was silenced by RNAi, the bacterial clearance ability in mud crab was decreased and the transcript levels of five antimicrobial peptides (AMPs) (SpCrustin, SpHistin, SpALF4 (anti-lipopolysaccharide factor), SpALF5 and SpALF6) were significantly decreased in hemocytes. In our study, knockdown of SpCTL-B could down-regulate the expression of SpSTAT at m

  19. Advanced Offshore Wind Turbine/Foundation Concept for the Great Lakes

    Energy Technology Data Exchange (ETDEWEB)

    Afjeh, Abdollah A. [Univ. of Toledo, OH (United States); Windpower, Nautica [Nautica Windpower, Olmsted Falls, OH (United States); Marrone, Joseph [OCC COWI, Vancouver (Canada); Wagner, Thomas [Nautica Windpower, Olmsted Falls, OH (United States)

    2013-08-29

    This project investigated a conceptual 2-bladed rotor wind turbine design and assessed its feasibility for installation in the Great Lakes. The levelized cost of energy was used for this purpose. A location in Lake Erie near the coast of Cleveland, Ohio was selected as the application site. The loading environment was defined using wind and wave data collected at a weather station in Lake Erie near Cleveland. In addition, the probability distributions of the annual significant wave height and wind speed were determined. A model of the dependence of the above two quantities was also developed and used in the study of wind turbine system loads. Loads from ice floes and ridges were also included.The NREL 5 MW 3-bladed rotor wind turbine concept was used as the baseline design. The proposed turbine design employs variable pitch blade control with tip-brakes and a teeter mechanism. The rotor diameter, rated power and the tower dimensions were selected to closely match those of the NREL 5 MW wind turbine.A semi-floating gravity base foundation was designed for this project primarily to adapt to regional logistical constraints to transport and install the gravity base foundation. This foundation consists of, from bottom to top, a base plate, a buoyancy chamber, a taper zone, a column (with ice cone), and a service platform. A compound upward-downward ice cone was selected to secure the foundation from moving because of ice impact.The turbine loads analysis was based on International ElectroTechnical Committee (IEC) Standard 61400-1, Class III winds. The NREL software FAST was the primary computational tool used in this study to determine all design load cases. An initial set of studies of the dynamics of wind turbines using Automatic Dynamic Analysis of Mechanical Systems (ADAMS) demonstrated that FAST and ADAMS load predictions were comparable. Because of its relative simplicity and short run times, FAST was selected for this study. For ice load calculations, a method

  20. Identification of novel HLA-A(*)0201-restricted CTL epitopes from Pokemon.

    Science.gov (United States)

    Yuan, Bangqing; Zhao, Lin; Xian, Ronghua; Zhao, Gang

    2012-01-01

    Pokemon is a member of the POK family of transcriptional repressors and aberrant overexpressed in various human cancers. Therefore, the related peptide epitopes derived from Pokemon is essential for the development of specific immunotherapy of malignant tumors. In this study, we predicted and identified HLA-A(*)0201-restricted cytotoxic T lymphocyte (CTL) epitopes derived from Pokemon with computer-based epitope prediction, peptide-binding assay and testing of the induced CTLs toward different kinds of carcinoma cells. The results demonstrated that effectors induced by peptides of Pokemon containing residues 32-40, 61-69, 87-95, and 319-327 could specifically secrete IFN-γ and lyse tumor cell lines of Pokemon-positive and HLA-A2-matched. The results suggest that Pokemon32, Pokemon61, Pokemon87, and Pokemon319 peptides are novel HLA-A(*)0201-restricted restricted CTL epitopes, and could be utilized in the cancer immunotherapy against a broad spectrum of tumors. Copyright © 2012 Elsevier Inc. All rights reserved.

  1. Optimalisasi Pembelajaran IPS Pada Siswa Kelas VI Melalui Metode Contextual Teaching And Learning (CTL

    Directory of Open Access Journals (Sweden)

    Mahfud Mahfud

    2014-08-01

    Full Text Available Peranan guru dalam pembelajaran IPS mempunyai hubungan erat dengan dengan cara mengaktifkan siswa dalam belajar, terutama dalam proses pengembangan kemampuan dan keterampilan.Untuk mengurangi sifat verbalisme siswa dan membantah pemahaman konsep yang terdapat dalam materi IPS yang terdapat di SD, guru diharapkan memiliki kemampuan untuk mengembangkan model interaktif dalam pembelajaran IPS serta mengidentifikasi sumber-sumber pelajaran. Salah satu model interaktif yang bisa diterapkan guru salah satunya adalah model pembelajaran kontekstual atau Contextual Teaching and Learning (CTL. Pembelajarn kontekstual merupakan suatu proses yang bertujuan untuk membantu siswa memahami materi pelajaran yang sedang mereka pelajari dengan menghubungkan pokok materi pelajaran dengan penerapannya dalam kehidupan sehari-hari.Dari hasil kegiatan penelitian tindakan kelas yang telah dilakukan dalam dua siklus terhadap siswa kelas VIA di SDN Pinggir Papas 1 Kecamatan Kalianget Kabupaten Sumenep, dan berdasarkan seluruh pembahasan dari hasil analisis yang telah dilakukan, dapat disimpulkan bahwaOptimalisasi Pembelajaran IPS pada Siswa Kelas VIAmelalui Metode Contextual Teaching And Learning(CTL dapat meningkatkan kemampuan siswa memahami materi pembelajaran IPS, sehingga berpengaruh terhadap peningkatan prestasi belajar siswa, serta siswa menjadi aktif dan tertarik mengikuti proses pembelajaranyang dilaksanakan oleh guru di kelas.

  2. ELISPOT Assay for Monitoring Cytotoxic T Lymphocytes (CTL Activity in Cancer Vaccine Clinical Trials

    Directory of Open Access Journals (Sweden)

    Thomas J. Sayers

    2012-05-01

    Full Text Available The profiling and monitoring of immune responses are key elements in the evaluation of the efficacy and development of new biotherapies, and a number of assays have been introduced for analyzing various immune parameters before, during, and after immunotherapy. The choice of immune assays for a given clinical trial depends on the known or suggested immunomodulating mechanisms associated with the tested therapeutic modality. Cell-mediated cytotoxicity represents a key mechanism in the immune response to various pathogens and tumors. Therefore, the selection of monitoring methods for the appropriate assessment of cell-mediated cytotoxicity is thought to be crucial. Assays that can detect both cytotoxic T lymphocytes (CTL frequency and function, such as the IFN-γ enzyme-linked immunospot assay (ELISPOT have gained increasing popularity for monitoring clinical trials and in basic research. Results from various clinical trials, including peptide and whole tumor cell vaccination and cytokine treatment, have shown the suitability of the IFN-γ ELISPOT assay for monitoring T cell responses. However, the Granzyme B ELISPOT assay and Perforin ELISPOT assay may represent a more direct analysis of cell-mediated cytotoxicity as compared to the IFN-γ ELISPOT, since Granzyme B and perforin are the key mediators of target cell death via the granule-mediated pathway. In this review we analyze our own data and the data reported by others with regard to the application of various modifications of ELISPOT assays for monitoring CTL activity in clinical vaccine trials.

  3. Advanced core physics and thermal hydraulics analysis of boiling water reactors using innovative fuel concepts

    International Nuclear Information System (INIS)

    Winter, Dominik

    2014-01-01

    The economical operation of a boiling water reactor (BWR) is mainly achieved by the axially uniform utilization of the nuclear fuel in the assemblies which is challenging because the neutron spectrum in the active reactor core varies with the axial position. More precisely, the neutron spectrum becomes harder the higher the position is resulting in a decrease of the fuel utilization because the microscopic fission cross section is smaller by several orders of magnitude. In this work, the use of two fuel concepts based on a mixed oxide (MOX) fuel and an innovative thorium-plutonium (ThPu) fuel is investigated by a developed simulation model encompassing thermal hydraulics, neutronics, and fuel burnup. The main feature of these fuel concepts is the axially varying enrichment in plutonium which is, in this work, recycled from spent nuclear fuel and shows a high fission fraction of the absorption cross section for fast incident neutron energies. The potential of balancing the overall fuel utilization by an increase of the fission rate in the upper part of the active height with a combination of the harder spectrum and the higher fission fraction of the absorption cross section in the BWR core is studied. The three particular calculational models for thermal hydraulics, neutronics, and fuel burnup provide results at fuel assembly and/or at core level. In the former case, the main focus lies on the thermal hydraulics analysis, fuel burnup, and activity evolution after unloading from the core and, in the latter case, special attention is paid to reactivity safety coefficients (feedback effects) and the optimization of the operational behavior. At both levels (assembly and core), the isotopic buildup and depletion rates as a function of the active height are analyzed. In addition, a comparison between the use of conventional fuel types with homogeneous enrichments and the use of the innovative fuel types is made. In the framework of the simulations, the ThPu and the MOX

  4. Comparative Omics and Trait Analyses of Marine Pseudoalteromonas Phages Advance the Phage OTU Concept

    Directory of Open Access Journals (Sweden)

    Melissa B. Duhaime

    2017-07-01

    Full Text Available Viruses influence the ecology and evolutionary trajectory of microbial communities. Yet our understanding of their roles in ecosystems is limited by the paucity of model systems available for hypothesis generation and testing. Further, virology is limited by the lack of a broadly accepted conceptual framework to classify viral diversity into evolutionary and ecologically cohesive units. Here, we introduce genomes, structural proteomes, and quantitative host range data for eight Pseudoalteromonas phages isolated from Helgoland (North Sea, Germany and use these data to advance a genome-based viral operational taxonomic unit (OTU definition. These viruses represent five new genera and inform 498 unaffiliated or unannotated protein clusters (PCs from global virus metagenomes. In a comparison of previously sequenced Pseudoalteromonas phage isolates (n = 7 and predicted prophages (n = 31, the eight phages are unique. They share a genus with only one other isolate, Pseudoalteromonas podophage RIO-1 (East Sea, South Korea and two Pseudoalteromonas prophages. Mass-spectrometry of purified viral particles identified 12–20 structural proteins per phage. When combined with 3-D structural predictions, these data led to the functional characterization of five previously unidentified major capsid proteins. Protein functional predictions revealed mechanisms for hijacking host metabolism and resources. Further, they uncovered a hybrid sipho-myovirus that encodes genes for Mu-like infection rarely described in ocean systems. Finally, we used these data to evaluate a recently introduced definition for virus populations that requires members of the same population to have >95% average nucleotide identity across at least 80% of their genes. Using physiological traits and genomics, we proposed a conceptual model for a viral OTU definition that captures evolutionarily cohesive and ecologically distinct units. In this trait-based framework, sensitive hosts are

  5. Atmospheric fluidized bed combustion advanced system concepts applicable to small industrial and commercial markets. Topical report, Level 2

    Energy Technology Data Exchange (ETDEWEB)

    Ake, T.R.; Dixit, V.B.; Mongeon, R.K.

    1992-09-01

    As part of an overall strategy to promote FBC coal combustion and to improve the marketability of the eastern coals, the US Department of Energy`s Morgantown Energy Research Center awarded a three level contract to Riley Stoker Corporation to develop advanced Multi Solids Fluidized Bed (MSFB) boiler designs. The first level of this contract targeted the small package boiler (10,000--50,000 lb/hr steam) and industrial size boiler (75,000--150,000 lb/hr steam) markets. Two representative sizes, 30,000 lb/hr and 110,000 lb/hr of steam, were selected for the two categories for a detailed technical and economic evaluation. Technically, both the designs showed promise, however, the advanced industrial design was favored on economic considerations. It was thus selected for further study in the second level of the contract. Results of this Level-2 effort, presented in this report, consisted of testing the design concept in Riley`s 4.4 MBtu/hr pilot MSFB facility located at Riley Research Center in Worcester, Mass. The design and economics of the proof of concept facility developed in Level-1 of the contract were then revised in accordance with the findings of the pilot test program. A host site for commercial demonstration in Level-3 of the contract was also secured. It was determined that co-firing coal in combination with paper de-inking sludge will broaden the applicability of the design beyond conventional markets. International Paper (IP), the largest paper company in the world, is willing to participate in this part of the program. IP has offered its Hammermill operation at Lockhaven, Pa, site of a future paper de-inking plant, for the proof of concept installation. This plant will go in operation in 1994. It is recommended that METC proceed to the commercial demonstration of the design developed. The approach necessary to satisfy the needs of the customer while meeting the objectives of this program is presented along with a recommended plan of action.

  6. ROBOTICALLY ENHANCED ADVANCED MANUFACTURING CONCEPTS TO OPTIMIZE ENERGY, PRODUCTIVITY, AND ENVIRONMENTAL PERFORMANCE

    Energy Technology Data Exchange (ETDEWEB)

    Larry L. Keller; Joseph M. Pack; Robert V. Kolarik II

    2007-11-05

    In the first phase of the REML project, major assets were acquired for a manufacturing line for follow-on installation, capability studies and optimization. That activity has been documented in the DE-FC36-99ID13819 final report. In this the second phase of the REML project, most of the major assets have been installed in a manufacturing line arrangement featuring a green cell, a thermal treatment cell and a finishing cell. Most of the secondary and support assets have been acquired and installed. Assets have been integrated with a commercial, machine-tending gantry robot in the thermal treatment cell and with a low-mass, high-speed gantry robot in the finish cell. Capabilities for masterless gauging of product’s dimensional and form characteristics were advanced. Trial production runs across the entire REML line have been undertaken. Discrete event simulation modeling has aided in line balancing and reduction of flow time. Energy, productivity and cost, and environmental comparisons to baselines have been made. Energy The REML line in its current state of development has been measured to be about 22% (338,000 kVA-hrs) less energy intensive than the baseline conventional low volume line assuming equivalent annual production volume of approximately 51,000 races. The reduction in energy consumption is largely attributable to the energy reduction in the REML thermal treatment cell where the heating devices are energized on demand and are appropriately sized to the heating load of a near single piece flow line. If additional steps such as power factor correction and use of high-efficiency motors were implemented to further reduce energy consumption, it is estimated, but not yet demonstrated, that the REML line would be about 30% less energy intensive than the baseline conventional low volume line assuming equivalent annual production volume. Productivity The capital cost of an REML line would be roughly equivalent to the capital cost of a new conventional line. The

  7. Induction of cytotoxic T-cell responses by gene gun DNA vaccination with minigenes encoding influenza A virus HA and NP CTL-epitopes

    DEFF Research Database (Denmark)

    Fomsgaard, A; Nielsen, H V; Kirkby, N

    1999-01-01

    degree of controllability. We have examined the induction of murine CTL's by this approach using DNA plasmid minigene vaccines encoding known mouse K(k) minimal CTL epitopes (8 amino acids) from the influenza A virus hemagglutinin and nucleoprotein. We here report that such an approach is feasible...

  8. Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency.

    Science.gov (United States)

    Umeshappa, Channakeshava S; Nanjundappa, Roopa H; Xie, Yufeng; Freywald, Andrew; Xu, Qingyong; Xiang, Jim

    2013-04-01

    Increased CD8(+) T-cell precursor frequency (PF) precludes the requirement of CD4(+) helper T (Th) cells for primary CD8(+) cytotoxic T-lymphocyte (CTL) responses. However, the key questions of whether unhelped CTLs generated at higher PF are functional effectors, and whether unhelped CTLs can differentiate into functional memory cells at higher PF are unclear. In this study, ovalbumin (OVA) -pulsed dendritic cells (DC(OVA)) derived from C57BL/6, CD40 knockout (CD40(-/-)) or CD40 ligand knockout (CD40L(-/-)) mice were used to immunize C57BL/6, Ia(b-/-), CD40(-/-) or CD40L(-/-) mice, whose PF was previously increased with transfer of 1 × 10(6) CD8(+) T cells derived from OVA-specific T-cell receptor (TCR) transgenic OTI, OTI(CD40(-/-)) or OTI(CD40L(-/-)) mice. All the immunized mice were then assessed for effector and memory CTL responses. Following DC immunization, relatively comparable CTL priming occurred without CD4(+) T-cell help and Th-provided CD40/CD40L signalling. In addition, the unhelped CTLs were functional effectors capable of inducing therapeutic immunity against established OVA-expressing tumours. In contrast, the functional memory development of CTLs was severely impaired in the absence of CD4(+) T-cell help and CD40/CD40L signalling. Finally, unhelped memory CTLs failed to protect mice against lethal tumour challenge. Taken together, these results demonstrate that CD4(+) T-cell help at higher PF, is not required for effector CTL priming, but is required for functional memory CTL development against cancer. Our data may impact the development of novel preventive and therapeutic approaches in cancer patients with compromised CD4(+) T-cell functions. © 2012 Blackwell Publishing Ltd.

  9. Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based vector system.

    Science.gov (United States)

    Han, Seung-Soo; Lee, Jinjoo; Jung, Yideul; Kang, Myeong-Ho; Hong, Jung-Hyub; Cha, Min-Suk; Park, Yu-Jin; Lee, Ezra; Yoon, Cheol-Hee; Bae, Yong-Soo

    2015-09-11

    We developed a CTL vaccine vector by modification of the RPS-Vax system, a mucosal vaccine vector derived from a poliovirus Sabin 1 strain, and generated an oral CTL vaccine against HIV-1. A DNA fragment encoding a cytoplasmic transduction peptide (CTP) was integrated into the RPS-Vax system to generate RPS-CTP, a CTL vaccine vector. An HIV-1 p24 cDNA fragment was introduced into the RPS-CTP vector system and a recombinant poliovirus (rec-PV) named vRPS-CTP/p24 was produced. vRPS-CTP/p24 was genetically stable and efficiently induced Th1 immunity and p24-specific CTLs in immunized poliovirus receptor-transgenic (PVR-Tg) mice. In challenge experiments, PVR-Tg mice that were pre-immunized orally with vRPS-CTP/p24 were resistant to challenge with a lethal dose of p24-expressing recombinant vaccinia virus (rMVA-p24). These results suggested that the RPS-CTP vector system had potential for developing oral CTL vaccines against infectious diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. UPAYA MENGEMBANGKAN LEARNING COMMUNITY SISWA KELAS X SMA MELALUI PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBASIS CTL PADA PEMBELAJARAN FISIKA

    Directory of Open Access Journals (Sweden)

    Wahyudi -

    2012-04-01

    Full Text Available Penelitian ini bertujuan untuk mendeskripsikan penerapan model pembelajaran kooperatif tipe STAD berbasis CTL pada pembelajaran fisika dalam mengembangkan learning community dan meningkatkan hasil belajar siswa serta mengetahui dampak penerapannya terhadap learning community dan hasil belajar siswa kelas X-7 SMA N 1 Tahunan Jepara. Hasil penelitian menunjukkan meningkatnya hasil belajar serta berkembangnya learning community siswa kelas X-7 SMA N 1 Tahunan Jepara setelah penerapan model pembelajaran kooperatif tipe STAD berbasis CTL pada pokok bahasan listrik dinamis.This research is describe the implementation of cooperative learning model STAD CTL-based for Physics learning subject to develop learning community, improve students learning and also find out the outcome of its implementation  to the learning community and learning result of SMA N 1 Tahunan Jepara Students class of X-7. The research result shows that there is an improvement of students’ learning result and also a development of learning community of N 1 Tahunan Jepara Students class of X-7 after implementing cooperative learning model STAD CTL-based for Dynamic Electricity topic.

  11. Characterization of Gag and Nef-specific ELISpot-based CTL responses in HIV-1 infected Indian individuals.

    Science.gov (United States)

    Mendiratta, Sanjay; Vajpayee, Madhu; Malhotra, Uma; Kaushik, Shweta; Dar, Lalit; Mojumdar, Kamalika; Chauhan, Neeraj Kumar; Sreenivas, Vishnubhatla

    2009-02-01

    Cytotoxic T lymphocyte (CTL) responses to Gag have been most frequently linked to control of viremia whereas CTL responses to Nef have direct relationship with viral load. IFN-gamma ELISpot assay was used to screen CTL responses at single peptide level directed at HIV-1 subtype C Gag and Nef proteins in 30 antiretroviral therapy naive HIV-1 infected Indian individuals. PBMCs from 73.3% and 90% of the study population showed response to Gag and Nef antigens, respectively. The magnitude of Gag-specific CTL responses was inversely correlated with plasma viral load (r = -0.45, P = 0.001), whereas magnitude of Nef-specific responses was directly correlated (r = 0.115). Thirteen immunodominant regions (6 in Gag, 7 in Nef) were identified in the current study. The identification of Gag and Nef-specific responses across HIV-1 infected Indian population and targeting epitopes from multiple immunodominant regions may provide useful insight into the designing of new immunotherapy and vaccines.

  12. Keefektifan Implementasi CTL berbantuan Komik Matematika dan Langkah Penyelesaian Krulik dan Rudnick untuk Meningkatkan Kemampuan Pemahaman dan Disposisi Matematis Siswa

    Directory of Open Access Journals (Sweden)

    Christina Widayanti

    2017-03-01

    Full Text Available This study aims to know the effectiveness of the CTL models aided by mathematical comics and Krulik and Rudnick’s steps in problem solving to improve the ability of student’s mathematical understanding and disposition. Population in this study were VIIIA grade students up to VIIIE of SMP Negeri 1 Pulokulon year 2015/2016 with a true experimental design types posttest­only control design and samples are chosen randomly. Data analysis that used in this study were an average of completeness test, the proportion test, the average difference test, and Mann­Whitney test. The results showed that (1 the ability of student’s mathematical understanding of the subject that have gained CTL models aided by mathematical comics and Krulik and Rudnick’s steps in problem solving have achieved the completeness in groups and classical; (2 the ability of student’s mathematical understanding of students who have gained CTL models aided by mathematical comics and Krulik and Rudnick’s steps in problem solving more than students with expository models aided by LKS, (3 the mathematical disposition of student’s who have gained CTL models aided by mathematical comics and Krulik and Rudnick’s steps in problem solving more than students with expository models aided by LKS.

  13. Advanced cementation concepts

    International Nuclear Information System (INIS)

    Howard, C.G.

    1989-10-01

    The purpose of this programme of work was to investigate whether improvements could be made to existing formulations for cement suitable for the immobilization of intermediate level radioactive waste. Two additives were selected, microsilica and limestone flour. Improvements to the cement were only slight. (author)

  14. Advanced Accelerator Concepts

    Science.gov (United States)

    Siemann, Robert

    1998-04-01

    Current particle accelerators rely on conventional or superconducting radio frequency cavities to accelerate beams of protons or electrons for nuclear and particle research and for medical and materials science studies. New methods for achieving larger accelerating gradients have been proposed and are being studied. These include the use of high power lasers, laser driven plasmas, wake fields generated by intense low energy beams, and millimeter wavelength EM structures. The studies to date, and the prospects for practical applications of these new ideas will be discussed.

  15. Advanced ADS concepts

    International Nuclear Information System (INIS)

    Slessarev, I.

    2001-01-01

    Current Nuclear Power has already proved its ability to be used as one of the principal means of the large scale energy production throughout the world. There is the widely spread opinion that many of the problems can be resolved if LWR's would be able to close its fuel cycle (MOX-strategy). Really, closure of fuel cycle (if it could be realised technically in full degree) leads to the reduction of the TRU-accumulation rate and of the most worrying long-lived fuel waste by factor of 10 -30 and, hence, to facilitation the waste repository problems. Analysis shows that one of the most important problems with MOX-type fuelled LWR exploitation is its potential safety degradation due to corresponding degradation of some principal physical parameters. Non-favourable feed back effects, delayed neutron fraction reduction, etc. lead, probably, to some important constraints in fuel multirecycling fraction. However, if the LWR's fuel cycle closure would be even realised, other, not less important, key-issues will rest unresolved or even more aggravated such as the economical competitiveness, weapons material proliferation, fuel resources, natural safety level, etc. Possible replacement of LWR's park by Sodium Fast Reactors (SFR) is able to change some accents in NP acceptance, however, can not change this situation drastically. Really, the potential of the waste long-term toxicity reduction is slightly favourable for SFR's than for LWRs (by the factor of 1.5 [1,2]) and this benefit is indebted mostly due to the higher fuel burnup potential of SFR's. Hence, the waste toxicity reduction factor, when SFR fuel cycle will be closed, is expecting to be in the interval 20-50 and, hence, it is slightly better than for LWRs. Nevertheless, it is important to mention that the closure of fast reactors fuel cycles does not lead to important degradation of safety physics. TRU equilibrium inventory is one of penalising factors of fast reactors: the total TRU inventory in NP, based on SFR, will be higher (roughly, by factor of 2) than for LWR based Np

  16. MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells

    Science.gov (United States)

    Catalán, Elena; Charni, Seyma; Jaime, Paula; Aguiló, Juan Ignacio; Enríquez, José Antonio; Naval, Javier; Pardo, Julián; Villalba, Martín; Anel, Alberto

    2015-01-01

    Tumor cells have a tendency to use glucose fermentation to obtain energy instead of mitochondrial oxidative phosphorylation (OXPHOS). We demonstrated that this phenotype correlated with loss of ERK5 expression and with reduced MHC class I expression. Consequently, tumor cells could evade cytotoxic T lymphocyte (CTL)-mediated immune surveillance, but also increase their sensitivity to natural killer (NK) cells. These outcomes were evaluated using two cellular models: leukemic EL4 cells and L929 transformed fibroblasts and their derived ρ° cell lines, which lack mitochondrial DNA. We have also used a L929 cell sub-line that spontaneously lost matrix attachment (L929dt), reminiscent of metastasis generation, that also downregulated MHC-I and ERK5 expression. MHC-I expression is lower in ρ° cells than in the parental cell lines, but they were equally sensitive to CTL. On the contrary, ρ° cells were more sensitive to activated NK cells than parental cells. On the other hand, L929dt cells were resistant to CTL and NK cells, showed reduced viability when forced to perform OXPHOS, and surviving cells increased MHC-I expression and became sensitive to CTL. The present results suggest that when the reduction in MHC-I levels in tumor cells due to glycolytic metabolism is partial, the increase in sensitivity to NK cells seems to predominate. However, when tumor cells completely lose MHC-I expression, the combination of treatments that increase OXPHOS with CTL-mediated immunotherapy could be a promising therapeutic approach. PMID:25949869

  17. MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells.

    Science.gov (United States)

    Catalán, Elena; Charni, Seyma; Jaime, Paula; Aguiló, Juan Ignacio; Enríquez, José Antonio; Naval, Javier; Pardo, Julián; Villalba, Martín; Anel, Alberto

    2015-01-01

    Tumor cells have a tendency to use glucose fermentation to obtain energy instead of mitochondrial oxidative phosphorylation (OXPHOS). We demonstrated that this phenotype correlated with loss of ERK5 expression and with reduced MHC class I expression. Consequently, tumor cells could evade cytotoxic T lymphocyte (CTL)-mediated immune surveillance, but also increase their sensitivity to natural killer (NK) cells. These outcomes were evaluated using two cellular models: leukemic EL4 cells and L929 transformed fibroblasts and their derived ρ° cell lines, which lack mitochondrial DNA. We have also used a L929 cell sub-line that spontaneously lost matrix attachment (L929dt), reminiscent of metastasis generation, that also downregulated MHC-I and ERK5 expression. MHC-I expression is lower in ρ° cells than in the parental cell lines, but they were equally sensitive to CTL. On the contrary, ρ° cells were more sensitive to activated NK cells than parental cells. On the other hand, L929dt cells were resistant to CTL and NK cells, showed reduced viability when forced to perform OXPHOS, and surviving cells increased MHC-I expression and became sensitive to CTL. The present results suggest that when the reduction in MHC-I levels in tumor cells due to glycolytic metabolism is partial, the increase in sensitivity to NK cells seems to predominate. However, when tumor cells completely lose MHC-I expression, the combination of treatments that increase OXPHOS with CTL-mediated immunotherapy could be a promising therapeutic approach.

  18. Equipment concept design and development plans for microgravity science and applications research on space station: Combustion tunnel, laser diagnostic system, advanced modular furnace, integrated electronics laboratory

    Science.gov (United States)

    Uhran, M. L.; Youngblood, W. W.; Georgekutty, T.; Fiske, M. R.; Wear, W. O.

    1986-01-01

    Taking advantage of the microgravity environment of space NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. Previous studies have been performed to define from the researcher's perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. Functional requirements for the identified experimental apparatus and support equipment were determined. From these hardware requirements, several items were selected for concept designs and subsequent formulation of development plans. This report documents the concept designs and development plans for two items of experiment apparatus - the Combustion Tunnel and the Advanced Modular Furnace, and two items of support equipment the Laser Diagnostic System and the Integrated Electronics Laboratory. For each concept design, key technology developments were identified that are required to enable or enhance the development of the respective hardware.

  19. Application of Design of Experiments and Surrogate Modeling within the NASA Advanced Concepts Office, Earth-to-Orbit Design Process

    Science.gov (United States)

    Zwack, Mathew R.; Dees, Patrick D.; Holt, James B.

    2016-01-01

    Decisions made during early conceptual design have a large impact upon the expected life-cycle cost (LCC) of a new program. It is widely accepted that up to 80% of such cost is committed during these early design phases. Therefore, to help minimize LCC, decisions made during conceptual design must be based upon as much information as possible. To aid in the decision making for new launch vehicle programs, the Advanced Concepts Office (ACO) at NASA Marshall Space Flight Center (MSFC) provides rapid turnaround pre-phase A and phase A concept definition studies. The ACO team utilizes a proven set of tools to provide customers with a full vehicle mass breakdown to tertiary subsystems, preliminary structural sizing based upon worst-case flight loads, and trajectory optimization to quantify integrated vehicle performance for a given mission. Although the team provides rapid turnaround for single vehicle concepts, the scope of the trade space can be limited due to analyst availability and the manpower requirements for manual execution of the analysis tools. In order to enable exploration of a broader design space, the ACO team has implemented an advanced design methods (ADM) based approach. This approach applies the concepts of design of experiments (DOE) and surrogate modeling to more exhaustively explore the trade space and provide the customer with additional design information to inform decision making. This paper will first discuss the automation of the ACO tool set, which represents a majority of the development effort. In order to fit a surrogate model within tolerable error bounds a number of DOE cases are needed. This number will scale with the number of variable parameters desired and the complexity of the system's response to those variables. For all but the smallest design spaces, the number of cases required cannot be produced within an acceptable timeframe using a manual process. Therefore, automation of the tools was a key enabler for the successful

  20. Needs of Advanced Safeguards Technologies for Future Nuclear Fuel Cycle (FNFC) Facilities and a Trial Application of SBD Concept to Facility Design of a Hypothetical FNFC Facility

    International Nuclear Information System (INIS)

    Seya, M.; Hajima, R.; Nishimori, N.; Hayakawa, T.; Kikuzawa, N.; Shizuma, T.; Fujiwara, M.

    2010-01-01

    Some of future nuclear fuel cycle (FNFC) facilities are supposed to have the characteristic features of very large throughput of plutonium, low decontamination reprocessing (no purification process; existence of certain amount of fission products (FP) in all process material), full minor actinides (MA) recycle, and treatment of MOX with FP and MA in fuel fabrication. In addition, the following international safeguards requirements have to be taken into account for safeguards approaches of the FNFC facilities. -Application of integrated safeguards (IS) approach; -Remote (unattended) verification; - 'Safeguards by Design' (SBD) concept. These features and requirements compel us to develop advanced technologies, which are not emerged yet. In order to realize the SBD, facility designers have to know important parts of design information on advanced safeguards systems before starting the facility design. The SBD concept requires not only early start of R and D of advanced safeguards technologies (before starting preliminary design of the facility) but also interaction steps between researchers working on safeguards systems and nuclear facility designers. The interaction steps are follows. Step-1; researchers show images of advanced safeguards systems to facility designers based on their research. Step-2; facility designers take important design information on safeguards systems into process systems of demonstration (or test) facility. Step-3; demonstration and improvement of both systems based on the conceptual design. Step-4; Construction of a FNFC facility with the advanced safeguards systems We present a trial application of the SBD concept to a hypothetical FNFC facility with an advanced hybrid K-edge densitometer and a Pu NDA system for spent nuclear fuel assembly using laser Compton scattering (LCS) X-rays and γ-rays and other advanced safeguards systems. (author)

  1. Chitinase-like (CTL) and cellulose synthase (CESA) gene expression in gelatinous-type cellulosic walls of flax (Linum usitatissimum L.) bast fibers.

    Science.gov (United States)

    Mokshina, Natalia; Gorshkova, Tatyana; Deyholos, Michael K

    2014-01-01

    Plant chitinases (EC 3.2.1.14) and chitinase-like (CTL) proteins have diverse functions including cell wall biosynthesis and disease resistance. We analyzed the expression of 34 chitinase and chitinase-like genes of flax (collectively referred to as LusCTLs), belonging to glycoside hydrolase family 19 (GH19). Analysis of the transcript expression patterns of LusCTLs in the stem and other tissues identified three transcripts (LusCTL19, LusCTL20, LusCTL21) that were highly enriched in developing bast fibers, which form cellulose-rich gelatinous-type cell walls. The same three genes had low relative expression in tissues with primary cell walls and in xylem, which forms a xylan type of secondary cell wall. Phylogenetic analysis of the LusCTLs identified a flax-specific sub-group that was not represented in any of other genomes queried. To provide further context for the gene expression analysis, we also conducted phylogenetic and expression analysis of the cellulose synthase (CESA) family genes of flax, and found that expression of secondary wall-type LusCESAs (LusCESA4, LusCESA7 and LusCESA8) was correlated with the expression of two LusCTLs (LusCTL1, LusCTL2) that were the most highly enriched in xylem. The expression of LusCTL19, LusCTL20, and LusCTL21 was not correlated with that of any CESA subgroup. These results defined a distinct type of CTLs that may have novel functions specific to the development of the gelatinous (G-type) cellulosic walls.

  2. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells.

    Science.gov (United States)

    Ghanaati, Shahram; Booms, Patrick; Orlowska, Anna; Kubesch, Alica; Lorenz, Jonas; Rutkowski, Jim; Landes, Constantin; Sader, Robert; Kirkpatrick, Cj; Choukroun, Joseph

    2014-12-01

    Choukroun's platelet-rich fibrin (PRF) is obtained from blood without adding anticoagulants. In this study, protocols for standard platelet-rich fibrin (S-PRF) (2700 rpm, 12 minutes) and advanced platelet-rich fibrin (A-PRF) (1500 rpm, 14 minutes) were compared to establish by histological cell detection and histomorphometrical measurement of cell distribution the effects of the centrifugal force (speed and time) on the distribution of cells relevant for wound healing and tissue regeneration. Immunohistochemistry for monocytes, T and B -lymphocytes, neutrophilic granulocytes, CD34-positive stem cells, and platelets was performed on clots produced from four different human donors. Platelets were detected throughout the clot in both groups, although in the A-PRF group, more platelets were found in the distal part, away from the buffy coat (BC). T- and B-lymphocytes, stem cells, and monocytes were detected in the surroundings of the BC in both groups. Decreasing the rpm while increasing the centrifugation time in the A-PRF group gave an enhanced presence of neutrophilic granulocytes in the distal part of the clot. In the S-PRF group, neutrophils were found mostly at the red blood cell (RBC)-BC interface. Neutrophilic granulocytes contribute to monocyte differentiation into macrophages. Accordingly, a higher presence of these cells might be able to influence the differentiation of host macrophages and macrophages within the clot after implantation. Thus, A-PRF might influence bone and soft tissue regeneration, especially through the presence of monocytes/macrophages and their growth factors. The relevance and feasibility of this tissue-engineering concept have to be proven through in vivo studies.

  3. “You can get there from here”: Advanced low cost propulsion concepts for small satellites beyond LEO

    Science.gov (United States)

    Baker, Adam M.; da Silva Curiel, Alex; Schaffner, Jake; Sweeting, Martin

    2005-07-01

    microsatellite from a typical 700 km sun-synchronous orbit to a lower or higher orbit using a low cost 40 N thrust concentrated hydrogen peroxide/kerosene bipropellant engine. A spin stabilized 'tug' concept capable of providing between 130 and 300 m/s of deltaV to the payload is described. Transfer of an enhanced microsatellite from LEO to lunar orbit using a novel, storable propellant solar thermal propulsion system under development at the Surrey Space Centre. The solar thermal propulsion unit is designed for low cost small satellite support and will be compared with a more traditional approach using and industry standard storable bipropellant chemical engine. Nanosatellite manoeuvring for formation flying using advanced low power electric propulsion. A colloid thruster system concept is planned for development jointly between SSTL, Queen Mary University London and Rutherford Appleton Laboratory, UK. The colloid thruster system is designed to complement an existing butane resistojet to give full 3-axis manoeuvrability to an upgraded SNAP nanosatellite platform which could be reflown in 2007 alongside ESA's Proba 2 technology demonstrator microsatellite. A comparison between low power resistojets, a colloid thruster system, and pulsed plasma thrusters for orbit manoeuvring of microsatellites will be made. This paper's final section will briefly describe some of the interplanetary missions which have been considered at the Surrey Space Centre, and will highlight the few as yet practical solutions for sending small spacecraft on high deltaV missions without the use of a costly upper stage.

  4. Generation and characterization of peptide-specific, MHC-restricted cytotoxic T lymphocyte (CTL) and helper T cell lines from unprimed T cells under microculture conditions.

    Science.gov (United States)

    Sambhara, S R; Upadhya, A G; Miller, R G

    1990-06-12

    We describe a microculture system for the generation of CTL and T helper cells against peptides. Tryptic digest and cyanogen bromide fragments of chicken ovalbumin and synthetic peptides of ovalbumin (323-339) and influenza virus (NP 365-380) were used to generate CTL and T helper lines from unprimed T cells. These lines were both peptide-specific and MHC-restricted. The relative ease of generating peptide-specific, MHC-restricted CTL and helper T cell lines with as few as 10(6) unprimed lymphocytes can be an efficient method of detecting potential immunogenic determinants of an antigen.

  5. CTL lysis: there is a hyperbolic relation of killing rate to exocytosable granzyme A for highly cytotoxic murine cytotoxic T lymphocytes.

    Science.gov (United States)

    Poe, M; Wu, J K; Talento, A; Koo, G C

    1996-06-10

    The lysis of susceptible targets by efficient cytotoxic T lymphocytes (CTL) increases both with time and with the ratio of CTL to target. Simple methods for calculating a killing rate constant from the time dependence of killing and for calculating the relation of the killing rate constant to the concentration of exocytosable granzyme A are given. Application of these methods to the killing of target cells by the highly efficient mouse CTL AR1 is presented. AR1 needed granzyme A for efficient killing. AR1 contained sufficient exocytosable granzyme A to kill at about 80% of the rate possible at infinite exocytosable granzyme A.

  6. Fostering clinical reasoning in physiotherapy : Comparing the effects of concept map study and concept map completion after example study in novice and advanced learners

    NARCIS (Netherlands)

    Montpetit-tourangeau, Katherine; Dyer, Joseph-omer; Hudon, Anne; Windsor, Monica; Charlin, Bernard; Mamede, Sílvia; Van Gog, Tamara

    2017-01-01

    Background: Health profession learners can foster clinical reasoning by studying worked examples presenting fully worked out solutions to a clinical problem. It is possible to improve the learning effect of these worked examples by combining them with other learning activities based on concept maps.

  7. Policy drivers and barriers for coal-to-liquids (CtL) technologies in the United States

    International Nuclear Information System (INIS)

    Vallentin, Daniel

    2008-01-01

    Because of a growing dependence on oil imports, powerful industrial, political and societal stakeholders in the United States are trying to enhance national energy security through the conversion of domestic coal into synthetic hydrocarbon liquid fuels-so-called coal-to-liquids (CtL) processes. However, because of the technology's high costs and carbon intensity, its market deployment is strongly affected by the US energy, technology and climate policy setting. This paper analyses and discusses policy drivers and barriers for CtL technologies in the United States and reaches the conclusion that an increasing awareness of global warming among US policy-makers raises the requirements for the technology's environmental performance and, thus, limits its potential to regional niche markets in coal-producing states or strategic markets, such as the military, with specific security and fuel requirements

  8. Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.

    Directory of Open Access Journals (Sweden)

    Jens Dinter

    2015-03-01

    Full Text Available Dendritic cells (DCs and macrophages (Møs internalize and process exogenous HIV-derived antigens for cross-presentation by MHC-I to cytotoxic CD8⁺ T cells (CTL. However, how degradation patterns of HIV antigens in the cross-presentation pathways affect immunodominance and immune escape is poorly defined. Here, we studied the processing and cross-presentation of dominant and subdominant HIV-1 Gag-derived epitopes and HLA-restricted mutants by monocyte-derived DCs and Møs. The cross-presentation of HIV proteins by both DCs and Møs led to higher CTL responses specific for immunodominant epitopes. The low CTL responses to subdominant epitopes were increased by pretreatment of target cells with peptidase inhibitors, suggestive of higher intracellular degradation of the corresponding peptides. Using DC and Mø cell extracts as a source of cytosolic, endosomal or lysosomal proteases to degrade long HIV peptides, we identified by mass spectrometry cell-specific and compartment-specific degradation patterns, which favored the production of peptides containing immunodominant epitopes in all compartments. The intracellular stability of optimal HIV-1 epitopes prior to loading onto MHC was highly variable and sequence-dependent in all compartments, and followed CTL hierarchy with immunodominant epitopes presenting higher stability rates. Common HLA-associated mutations in a dominant epitope appearing during acute HIV infection modified the degradation patterns of long HIV peptides, reduced intracellular stability and epitope production in cross-presentation-competent cell compartments, showing that impaired epitope production in the cross-presentation pathway contributes to immune escape. These findings highlight the contribution of degradation patterns in the cross-presentation pathway to HIV immunodominance and provide the first demonstration of immune escape affecting epitope cross-presentation.

  9. Generation of cytotoxic T lymphocytes in vitro. VII. Suppressive effect of irradiated MLC cells on CTL response

    International Nuclear Information System (INIS)

    Fitch, F.W.; Engers, H.D.; Cerottini, J.C.; Bruner, K.T.

    1976-01-01

    Irradiated cells obtained from MLC at the peak of the CTL response caused profound suppression of generation of CTL when added in small numbers at the initiation of primary MLC prepared with normal spleen cells. The inhibitory activity of the MLC cells was not affected by irradiation (1000 rads) but was abolished by treatment with anti-theta serum and complement. The suppression was immunologically specific. The response of A (H-2/sup a/) spleen cells toward C3H (H-2/sup k/) alloantigens was suppressed by irradiated MLC cells obtained from MLC prepared with A spleen cells and irradiated C3H-stimulating cells, whereas the response of A spleen cells toward DBA/2 (H-2/sup d/) alloantigens was affected relatively little. However, if irradiated C3H x DBA/2F1 hybrid spleen cells were used to stimulate A spleen cells in MLC, addition of irradiated MLC cells having cytotoxic activity toward C3H antigens abolished the response to both C3H and DBA/2 antigens. The response to DBA/2 antigens was much less affected when a mixture of irradiated C3H and DBA/2 spleen cells was used as stimulating cells. Thus, the presence of MLC cells having cytotoxic activity toward one alloantigen abolished the response to another non-cross-reacting antigen only when both antigens were present on the same F1 hybrid-stimulating cells. This suppression of generation of CTL by irradiated MLC cells apparently involves inactivation of alloantigen-bearing stimulating cells as a result of residual cytotoxic activity of the irradiated MLC cells. This mechanism may be active during the decline in CTL activity noted in the normal immune response in vivo and in vitro

  10. Modernization of the Radioisotopes Production Laboratory of the La Reina Nuclear Center in Chile: Incorporating advanced concepts of safety and good manufacturing practices

    International Nuclear Information System (INIS)

    Lagos Espinoza, Silvia

    2014-01-01

    A radioisotopes and radiopharmaceuticals production laboratory was established in Chile in the 1960s for research activities. From 1967 until January 2012, it was dedicated to the manufacturing of radioisotopes and radiopharmaceuticals for medical diagnosis and treatment purposes. In 2012, modernization of the facility’s design and technology began as part of the IAEA technical cooperation project, Modernizing the Radioisotopes Production Laboratory of La Reina Nuclear Centre by Incorporating Advanced Concepts of Safety and Good Manufacturing Practices, (CHI4022)

  11. CISH is induced during DC development and regulates DC-mediated CTL activation.

    Science.gov (United States)

    Miah, Mohammad Alam; Yoon, Cheol-Hee; Kim, Joonoh; Jang, Jinah; Seong, Young-Rim; Bae, Yong-Soo

    2012-01-01

    The cytokine inducible SH2-domain protein (CISH) is a well-known STAT5 target gene, but its role in the immune system remains uncertain. In this study, we found that CISH is predominantly induced during dendritic cell (DC) development from mouse bone marrow (BM) cells and plays a crucial role in type 1 DC development and DC-mediated CTL activation. CISH knockdown reduced the expression of MHC class I, co-stimulatory molecules and pro-inflammatory cytokines in BMDCs. Meanwhile, the DC yield was markedly enhanced by CISH knockdown via cell-cycle activation and reduction of cell apoptosis. Down-regulation of cell proliferation at the later stage of DC development was found to be associated with CISH-mediated negative feedback regulation of STAT5 activation. In T-cell immunity, OT-1 T-cell proliferation was significantly reduced by CISH knockdown in DCs, whereas OT-2 T-cell proliferation was not affected by CISH knockdown. CTLs generated by DC vaccination were also markedly reduced by CISH knockdown, followed by significant impairment of DC-based tumor immunotherapy. Taken together, our data suggest that CISH expression at the later stage of DC development triggers the shutdown of DC progenitor cell proliferation and facilitates DC differentiation into a potent stimulator of CTLs. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. An integrative approach to CTL epitope prediction: A combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions

    DEFF Research Database (Denmark)

    Larsen, Mette Voldby; Lundegaard, Claus; Lamberth, K

    2005-01-01

    Reverse immunogenetic approaches attempt to optimize the selection of candidate epitopes, and thus minimize the experimental effort needed to identify new epitopes. When predicting cytotoxic T cell epitopes, the main focus has been on the highly specific MHC class I binding event. Methods have al.......The method is available at http://www.cbs.dtu.dk/services/NetCTL. Supplementary material is available at http://www.cbs.dtu.dk/suppl/immunology/CTL.php....

  13. Eksprimentasi Pembelajaran Kooperatif Tipe Stad dan Tps dengan Pendekatan Ctl pada Materi Pokok Sistem Persamaan Linear Dua Variabel Ditinjau dari Gaya Belajar Siswa

    OpenAIRE

    Zamroni, Zamroni; Budiyono, Budiyono; Sujadi, Imam

    2013-01-01

    The objective of research was to find out: (1) which ones having better achievement, the students using TPS (Think Pair Share) learning with CTL approach or STAD (Students Teams Achievement Divisions) cooperative learning model with CTL approach or direct learning, (2) which ones having better learning achievement, the students with kinesthetic or visual or auditory learning style, (3) in each learning style, which ones having better achievement, the students using TPS (Think Pair Share) lear...

  14. Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 8. Operational Logic Flow Diagrams for a Generic Advanced Air Traffic Management system

    Science.gov (United States)

    1974-02-01

    The volume presents a description of the services a generic Advanced Air Traffic Management System (AATMS) should provide to the useres of the system to facilitate the safe, efficient flow of traffic. It provides a definition of the functions which t...

  15. Rejection of large HPV-16 expressing tumors in aged mice by a single immunization of VacciMax® encapsulated CTL/T helper peptides

    Directory of Open Access Journals (Sweden)

    MacDonald Lisa

    2007-06-01

    Full Text Available Abstract The incidence of cancer increases significantly in later life, yet few pre-clinical studies of cancer immunotherapy use mice of advanced age. A novel vaccine delivery platform (VacciMax®,VM is described that encapsulates antigens and adjuvants in multilamellar liposomes in a water-in-oil emulsion. The therapeutic potential of VM-based vaccines administered as a single dose was tested in HLA-A2 transgenic mice of advanced age (48–58 weeks old bearing large palpable TC1/A2 tumors. The VM-based vaccines contained one or more peptides having human CTL epitopes derived from HPV 16 E6 and E7. VM formulations contained a single peptide, a mixture of four peptides or the same four peptides linked together in a single long peptide. All VM formulations contained PADRE and CpG as adjuvants and ISA51 as the hydrophobic component of the water-in-oil emulsion. VM-formulated vaccines containing the four peptides as a mixture or linked together in one long peptide eradicated 19-day old established tumors within 21 days of immunization. Peptide-specific cytotoxic cellular responses were confirmed by ELISPOT and intracellular staining for IFN-γ producing CD8+ T cells. Mice rendered tumor-free by vaccination were re-challenged in the opposite flank with 10 million HLF-16 tumor cells, another HLA-A2/E6/E7 expressing tumor cell line. None of these mice developed tumors following the re-challenge. In summary, this report describes a VM-formulated therapeutic vaccine with the following unprecedented outcome: a eradication of large tumors (> 700 mm3 b in mice of advanced age c in less than three weeks post-immunization d following a single vaccination.

  16. Concept for a Satellite-Based Advanced Air Traffic Management System : Volume 4. Operational Description and Qualitative Assessment.

    Science.gov (United States)

    1974-02-01

    The volume presents a description of how the Satellite-Based Advanced Air Traffic Management System (SAATMS) operates and a qualitative assessment of the system. The operational description includes the services, functions, and tasks performed by the...

  17. PENINGKATAN HASIL BELAJAR MATA PELAJARAN EKONOMI DENGAN PENERAPAN MODEL PEMBELAJARAN CONTEXTUAL TEACHING AND LEARNING (CTL

    Directory of Open Access Journals (Sweden)

    Nur Alifah Fitriana

    2013-02-01

    Full Text Available Proses pembelajaran yang variatif akan membantu siswa dalam pemahaman materi pembelajaran yang diberikan oleh guru. Pada sekolah MA Yasis AT-Taqwa Pahesan, model pembelajaran yang digunakan masih menggunakan model pembelajaran yang konvensional. Disini siswa kurang berperan aktif dalam proses belajar mengajar dan siswa akan cenderung merasa bosan. Untuk menyelesaikan masalah tersebut peneliti mencoba menerapkan model pembelajaran Contextual Teaching and Learning (CTLsebagai upaya meningkatkan hasil belajar siswa. Rancangan penelitian ini merupakan penelitian tindakan kelas dengan dua siklus, setiap siklus meliputi perencanaan, pelaksanaan, pengamatan dan refleksi. Hasil penelitian diperoleh nilai rata-rata pada siklus I yaitu 64,58 dengan ketuntasan klasikal 54,16%, sedangkan untuk siklus II nilai rata-ratanya 79,79 dengan ketuntasan klasikal 79,16%. Pada siklus I aktivitas siswa 55,47% dan siklus II menjadi 76,54%. Sedangkan kinerja guru pada siklus I 51,42% dan meningkat disiklus II 91,42%. Abstract ___________________________________________________________________ The learning processwill help studentsvariedin understandinglearning materialsprovided bythe teacher. AtschoolMAYasisAT-Taqwa Pahesan, learning modelused is stillusingconventionallearning models. Here thestudents areactively involved inthe learning processand students willtend to feelbored. To solvethe problem, the researcher tried toapply thelearning modelContextual Teaching andLearning(CTL as an effort toimprove student learning outcomes. The design ofthis studyisaction researchwithtwocycles, each cycleincluding planning, implementation, observationand reflection. The result showedthe average valuein the first cycleis64.58withclassical completeness54.16%, while forthe second cycleaverage value79.79withclassical completeness79.16%. In the first cycleof student activityand55.47% to76.54% the second cycle. While theperformance of teachersin the first cycleincreased51

  18. Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.

    Directory of Open Access Journals (Sweden)

    Jessica L Prince

    Full Text Available Initial studies of 88 transmission pairs in the Zambia Emory HIV Research Project cohort demonstrated that the number of transmitted HLA-B associated polymorphisms in Gag, but not Nef, was negatively correlated to set point viral load (VL in the newly infected partners. These results suggested that accumulation of CTL escape mutations in Gag might attenuate viral replication and provide a clinical benefit during early stages of infection. Using a novel approach, we have cloned gag sequences isolated from the earliest seroconversion plasma sample from the acutely infected recipient of 149 epidemiologically linked Zambian transmission pairs into a primary isolate, subtype C proviral vector, MJ4. We determined the replicative capacity (RC of these Gag-MJ4 chimeras by infecting the GXR25 cell line and quantifying virion production in supernatants via a radiolabeled reverse transcriptase assay. We observed a statistically significant positive correlation between RC conferred by the transmitted Gag sequence and set point VL in newly infected individuals (p = 0.02. Furthermore, the RC of Gag-MJ4 chimeras also correlated with the VL of chronically infected donors near the estimated date of infection (p = 0.01, demonstrating that virus replication contributes to VL in both acute and chronic infection. These studies also allowed for the elucidation of novel sites in Gag associated with changes in RC, where rare mutations had the greatest effect on fitness. Although we observed both advantageous and deleterious rare mutations, the latter could point to vulnerable targets in the HIV-1 genome. Importantly, RC correlated significantly (p = 0.029 with the rate of CD4+ T cell decline over the first 3 years of infection in a manner that is partially independent of VL, suggesting that the replication capacity of HIV-1 during the earliest stages of infection is a determinant of pathogenesis beyond what might be expected based on set point VL alone.

  19. [Report from the Committee for Advanced Therapies (CAT). Pitfalls on the way from concept to medical treatment with advanced therapy medicinal products].

    Science.gov (United States)

    Reiss, M; Büttel, I C; Schneider, C K

    2011-07-01

    Advanced therapy medicinal products (ATMP) are highly innovative and complex medicines. They comprise gene therapy medicinal products, somatic cell therapy medicinal products, and tissue-engineered products (TEP). With the European Regulation on ATMP that came into force in 2008, a consolidated regulatory framework was created, where the Committee for Advanced Therapies (CAT) at the European Medicines Agency (EMA) plays a central role. This article discusses pitfalls and challenges that the CAT has experienced in its discussions of various procedures. Often ATMPs are developed by small and medium-sized enterprises (SME) which also face nonscientific challenges. The CAT wishes to meet these challenges on a scientific and regulatory level during its 2010-2015 work program.

  20. Post LANDSAT D Advanced Concept Evaluation (PLACE). [with emphasis on mission planning, technological forecasting, and user requirements

    Science.gov (United States)

    1977-01-01

    An outline is given of the mission objectives and requirements, system elements, system concepts, technology requirements and forecasting, and priority analysis for LANDSAT D. User requirements and mission analysis and technological forecasting are emphasized. Mission areas considered include agriculture, range management, forestry, geology, land use, water resources, environmental quality, and disaster assessment.

  1. Validation of a Computational Model for the SLS Core Stage Oxygen Tank Diffuser Concept and the Low Profile Diffuser - An Advanced Development Design for the SLS

    Science.gov (United States)

    Brodnick, Jacob; Richardson, Brian; Ramachandran, Narayanan

    2015-01-01

    The Low Profile Diffuser (LPD) project originated as an award from the Marshall Space Flight Center (MSFC) Advanced Development (ADO) office to the Main Propulsion Systems Branch (ER22). The task was created to develop and test an LPD concept that could produce comparable performance to a larger, traditionally designed, ullage gas diffuser while occupying a smaller volume envelope. Historically, ullage gas diffusers have been large, bulky devices that occupy a significant portion of the propellant tank, decreasing the tank volume available for propellant. Ullage pressurization of spacecraft propellant tanks is required to prevent boil-off of cryogenic propellants and to provide a positive pressure for propellant extraction. To achieve this, ullage gas diffusers must slow hot, high-pressure gas entering a propellant tank from supersonic speeds to only a few meters per second. Decreasing the incoming gas velocity is typically accomplished through expansion to larger areas within the diffuser which has traditionally led to large diffuser lengths. The Fluid Dynamics Branch (ER42) developed and applied advanced Computational Fluid Dynamics (CFD) analysis methods in order to mature the LPD design from and initial concept to an optimized test prototype and to provide extremely accurate pre-test predictions of diffuser performance. Additionally, the diffuser concept for the Core Stage of the Space Launch System (SLS) was analyzed in a short amount of time to guide test data collection efforts of the qualification of the device. CFD analysis of the SLS diffuser design provided new insights into the functioning of the device and was qualitatively validated against hot wire anemometry of the exterior flow field. Rigorous data analysis of the measurements was performed on static and dynamic pressure data, data from two microphones, accelerometers and hot wire anemometry with automated traverse. Feasibility of the LPD concept and validation of the computational model were

  2. Investigating the Effect of Different Verbal Formats of Advance Organizers on Third Graders' Understanding of Heat Transfer Concept

    Science.gov (United States)

    Chuang, Hsueh-Hua; Liu, Han-Chin

    2014-01-01

    The emergence of computer and multimedia technology change the forms of instructional materials and instructional design plays an important role on student learning outcome in multimedia learning. Research has found that using advance organizers has the potential for achieving learning objectives. Thus, this study investigated how using different…

  3. Investigating the Effect of Different Verbal Formats of Advance Organizers on Third Graders' Understanding of Heat Transfer Concept

    Science.gov (United States)

    Chuang, Hsueh-Hua; Liu, Han-Chin

    2014-01-01

    The emergence of computer and multimedia technology change the forms of instructional materials and instructional design plays an important role on student learning outcome in multimedia learning. Research has found that using advance organizers has the potential for achieving learning objectives. Thus, this study investigated how using different…

  4. Hybridization of natural systems with advanced treatment processes for organic micropollutant removals: New concepts in multi-barrier treatment

    KAUST Repository

    Sudhakaran, Sairam; Maeng, Sungkyu; Amy, Gary L.

    2013-01-01

    ). With the depletion of water resources and high demand for power and chemical usage, efforts need to be made to judiciously use advanced treatment processes. There is a new interest in multiple barriers with synergies in which two coupled processes can function as a

  5. Hybridization of natural systems with advanced treatment processes for organic micropollutant removals: New concepts in multi-barrier treatment

    KAUST Repository

    Sudhakaran, Sairam

    2013-07-01

    In the past, emphasis has been on individual treatment processes comprising conventional treatment (coagulation, sedimentation, and filtration) followed by advanced treatment processes (adsorption, ion-exchange, oxidation, and membrane separation). With the depletion of water resources and high demand for power and chemical usage, efforts need to be made to judiciously use advanced treatment processes. There is a new interest in multiple barriers with synergies in which two coupled processes can function as a hybrid process. Within the context of this paper, the hybrid processes include a natural treatment process coupled with an advanced process. Pilot/full-scale studies have shown efficient removal of OMPs by these hybrid processes. With this hybridization, the usage of resources such as power and chemicals can be reduced. In this study, coupling/hybridization of aquifer recharge and recovery (ARR) with oxidation (O3), advanced oxidation process which involves OH radicals (AOP), nanofiltration (NF), reverse osmosis (RO) and granular activated carbon (GAC) adsorption for OMP removal was studied. O3 or AOP as a pre-treatment and GAC, NF, RO, or UV/chlorination as a post-treatment to ARR was studied. NF can be replaced by RO for removal of OMPs since studies have shown similar performance of NF to RO for removal of many OMPs, thereby reducing costs and providing a more sustainable approach. © 2013 Elsevier Ltd.

  6. Design features of BREST reactors. Experimental work to advance the concept of BREST reactors. Results and plans

    International Nuclear Information System (INIS)

    Filin, A.I.; Orlov, V.V.; Leonov, V.N.; Sila-Novitskij, A.G.; Smirnov, V.S.; Tsikunov, V.S.

    2001-01-01

    Principle designs of 300 MW(th) and 1200 MW(th) lead-cooled fast reactors are presented. Reactors of various output are shown to be built using the same principles. In conjunction with increased output and to implement inherent safety concept in BREST-1200 reactor design a number of new solutions, which may be used in BREST-300 concept too, has been taken including: pool-type reactor design not requiring metal vessel, hence, not limiting reactor power; new handling system allowing to reduce central hall and building dimensions as a whole; emergency cooling system using Field pipes, immersed directly in lead, which may be used to cool down reactor under normal conditions; by-pass line incorporated in coolant loop allowing to refuse the actively actuating valve initiated in pumps shut down. (author)

  7. Mucosal immunization with PLGA-microencapsulated DNA primes a SIV-specific CTL response revealed by boosting with cognate recombinant modified vaccinia virus Ankara

    International Nuclear Information System (INIS)

    Sharpe, Sally; Hanke, Tomas; Tinsley-Bown, Anne; Dennis, Mike; Dowall, Stuart; McMichael, Andrew; Cranage, Martin

    2003-01-01

    Systemically administered DNA encoding a recombinant human immunodeficiency virus (HIV) derived immunogen effectively primes a cytotoxic T lymphocyte (CTL) response in macaques. In this further pilot study we have evaluated mucosal delivery of DNA as an alternative priming strategy. Plasmid DNA, pTH.HW, encoding a multi-CTL epitope gene, was incorporated into poly(D,L-lactic-co-glycolic acid) microparticles of less than 10 μm in diameter. Five intrarectal immunizations failed to stimulate a circulating vaccine-specific CTL response in 2 Mamu-A*01 + rhesus macaques. However, 1 week after intradermal immunization with a cognate modified vaccinia virus Ankara vaccine MVA.HW, CTL responses were detected in both animals that persisted until analysis postmortem, 12 weeks after the final boost. In contrast, a weaker and less durable response was seen in an animal vaccinated with the MVA construct alone. Analysis of lymphoid tissues revealed a disseminated CTL response in peripheral and regional lymph nodes but not the spleen of both mucosally primed animals

  8. A novel C-type lectin from the sea cucumber Apostichopus japonicus (AjCTL-2) with preferential binding of d-galactose.

    Science.gov (United States)

    Wang, Hui; Xue, Zhuang; Liu, Zhaoqun; Wang, Weilin; Wang, Feifei; Wang, Ying; Wang, Lingling; Song, Linsheng

    2018-05-15

    C-type lectins (CTLs) are Ca 2+ dependent carbohydrate-binding proteins that share structural homology in their carbohydrate-recognition domains (CRDs). In the present study, a novel CTL was identified from sea cucumber Apostichopus japonicus (named as AjCTL-2). The deduced amino acid sequence of AjCTL-2 was homologous to CTLs from other animals with the identities ranging from 33% to 40%. It contained a canonical signal peptide at the N-terminus, a low density lipoprotein receptor class A (LDLa), a C1r/C1s/Uegf/bone morphogenetic protein 1 (CUB), and a CRD with two motifs Glu-Pro-Asn (EPN) and Trp-Asn-Asp (WND) in Ca 2+ binding site 2. The mRNA transcripts of AjCTL-2 were extensively expressed in all the tested tissues including respiratory tree, muscle, gut, coelomocyte, tube-foot, body wall and gonad, and the highest expression level of AjCTL-2 in coelomocyte was about 4.2-fold (p sea cucumber. Copyright © 2018. Published by Elsevier Ltd.

  9. Advanced Concept Studies for Supersonic Commercial Transports Entering Service in the 2018-2020 Period Phase 2

    Science.gov (United States)

    Morgenstern, John; Buonanno, Michael; Yao, Jixian; Murugappan, Mugam; Paliath, Umesh; Cheung, Lawrence; Malcevic, Ivan; Ramakrishnan, Kishore; Pastouchenko, Nikolai; Wood, Trevor; hide

    2015-01-01

    Lockheed Martin Aeronautics Company (LM), working in conjunction with General Electric Global Research (GE GR) and Stanford University, executed a 19 month program responsive to the NASA sponsored "N+2 Supersonic Validation: Advanced Concept Studies for Supersonic Commercial Transports Entering Service in the 2018-2020 Period" contract. The key technical objective of this effort was to validate integrated airframe and propulsion technologies and design methodologies necessary to realize a supersonic vehicle capable of meeting the N+2 environmental and performance goals. The N+2 program is aligned with NASA's Supersonic Project and is focused on providing system level solutions capable of overcoming the efficiency, environmental, and performance barriers to practical supersonic flight. The N+2 environmental and performance goals are outlined in the technical paper, AIAA-2014-2138 (Ref. 1) along with the validated N+2 Phase 2 results. Our Phase 2 efforts built upon our Phase 1 studies (Ref. 2) and successfully demonstrated the ability to design and test realistic configurations capable of shaped sonic booms over the width of the sonic boom carpet. Developing a shaped boom configuration capable of meeting the N+2 shaped boom targets is a key goal for the N+2 program. During the LM Phase 1 effort, LM successfully designed and tested a shaped boom trijet configuration (1021) capable of achieving 85 PLdB under track (forward and aft shock) and up to 28 deg off-track at Mach 1.6. In Phase 2 we developed a refined configuration (1044-2) that extended the under 85 PLdB sonic boom level over the entire carpet of 52 deg off-track at a cruise Mach number of 1.7. Further, the loudness level of the configuration throughout operational conditions calculates to an average of 79 PLdB. These calculations rely on propagation employing Burger's (sBOOM) rounding methodology, and there are indications that the configuration average loudness would actually be 75 PLdB. We also added

  10. Applying advanced analytics to guide emergency department operational decisions: A proof-of-concept study examining the effects of boarding.

    Science.gov (United States)

    Andrew Taylor, R; Venkatesh, Arjun; Parwani, Vivek; Chekijian, Sharon; Shapiro, Marc; Oh, Andrew; Harriman, David; Tarabar, Asim; Ulrich, Andrew

    2018-01-04

    Emergency Department (ED) leaders are increasingly confronted with large amounts of data with the potential to inform and guide operational decisions. Routine use of advanced analytic methods may provide additional insights. To examine the practical application of available advanced analytic methods to guide operational decision making around patient boarding. Retrospective analysis of the effect of boarding on ED operational metrics from a single site between 1/2015 and 1/2017. Times series were visualized through decompositional techniques accounting for seasonal trends, to determine the effect of boarding on ED performance metrics and to determine the impact of boarding "shocks" to the system on operational metrics over several days. There were 226,461 visits with the mean (IQR) number of visits per day was 273 (258-291). Decomposition of the boarding count time series illustrated an upward trend in the last 2-3 quarters as well as clear seasonal components. All performance metrics were significantly impacted (pstudy regarding the use of advanced analytics in daily ED operations, time series analysis provided multiple useful insights into boarding and its impact on performance metrics. Copyright © 2018. Published by Elsevier Inc.

  11. Environmentally Responsible Aviation (ERA) Project - N+2 Advanced Vehicle Concepts Study and Conceptual Design of Subscale Test Vehicle (STV) Final Report

    Science.gov (United States)

    Bonet, John T.; Schellenger, Harvey G.; Rawdon, Blaine K.; Elmer, Kevin R.; Wakayama, Sean R.; Brown, Derrell L.; Guo, Yueping

    2011-01-01

    NASA has set demanding goals for technology developments to meet national needs to improve fuel efficiency concurrent with improving the environment to enable air transportation growth. A figure shows NASA's subsonic transport system metrics. The results of Boeing ERA N+2 Advanced Vehicle Concept Study show that the Blended Wing Body (BWB) vehicle, with ultra high bypass propulsion systems have the potential to meet the combined NASA ERA N+2 goals. This study had 3 main activities. 1) The development of an advanced vehicle concepts that can meet the NASA system level metrics. 2) Identification of key enabling technologies and the development of technology roadmaps and maturation plans. 3) The development of a subscale test vehicle that can demonstrate and mature the key enabling technologies needed to meet the NASA system level metrics. Technology maturation plans are presented and include key performance parameters and technical performance measures. The plans describe the risks that will be reduced with technology development and the expected progression of technical maturity.

  12. How reliable must advanced nondestructive testing be? A concept for the prediction, validation and raised quality of NDT

    International Nuclear Information System (INIS)

    Nockemann, C.; Tillack, G.R.; Schnitger, D.; Heidt, H.

    1995-01-01

    A concept of the harmonic integration of the following three mainstays of the reliability of ndt is proposed: 1. Theoretical prediction of the reliability as a function of physical parameter by computer modelling of the test problem concerned and the ndt process; maximisation by variation of the parameters. 2. Experimental evaluation of the reliability of ndt processes by the application of statistical methods to test practice. 3. Increasing the reliability by the combination of several ndt methods in a standard DV environment and European interconnection and provision of a distributed databank system. International exchange of experience via telecommunication. (orig.) [de

  13. Organization of the 17th Advanced Accelerator Concepts (AAC16) Workshop by the IEEE. Final Scientific/Technical Report On AWARD NO. DE-SC0015635

    Energy Technology Data Exchange (ETDEWEB)

    Sutter, David F. [Inst. of Electrical and Electronics Engineers Inc., Piscataway, NJ (United States)

    2017-07-15

    The 2016 Workshop on Advanced Accelerator Concepts (AAC) was held at the Gaylord Hotel and Conference Center, National Harbor, Maryland, from July 31 through August 5, 2016. This workshop was the seventeenth in a biennial series that began at Los Alamos National Laboratory in 1982 with a workshop on laser acceleration of particles (see AIP Conf. Proc. 91). AAC16 was organized under the sponsorship of the IEEE Council on Superconductivity with financial support from the U. S. Department of Energy Office of High Energy Physics and the National Science Foundation. The scope of the AAC Workshop has grown since 1982 to encompass a broad range of topics related to advancing accelerator science and technology beyond its current scientific and technical limits and is now an internationally acknowledged forum for interdisciplinary discussions on advanced accelerator and beam physics/technology concepts covering the widest possible range of applications. The Workshop continued the trend of growing worldwide participation, attracting world wide participation. The Workshop had a total of 256 attendees comprising (including the U.S.) representatives from 11 countries representing 65 different institutions. Each day’s schedule began with plenary sessions covering broad, cross disciplinary interests or general tutorial topics as selected by the Program Committee, followed by a break out into more narrowly focused working groups. The Workshop was organized into eight Working Groups each with a published statement of topical focus, scope of discussion and goals. A summary of the Working Group activities and conclusions is included in the American Institute of Physics’ (AIP) Conference Proceedings now available as an on line open source document. It has been a long tradition of the AAC workshops to encourage strong student participation. This is accomplished in part by subsidizing student attendance, done for this work shop by using funds from the DOE and National Science

  14. Design concepts and advanced telerobotics development for facilities in the back end of the nuclear fuel cycle

    International Nuclear Information System (INIS)

    Feldman, M.J.

    1987-01-01

    In the Fuel Recycle Division at the Oak Ridge National Laboratory (ORNL), a comprehensive remote systems development program has existed for the past seven years. The new remote technology under development is expected to significantly improve remote operations by extending the range of tasks accomplished by remote means and increasing the efficiency of remote work undertaken. Five areas of the development effort are primary contributors to the goal of higher operating efficiency for major facilities for the back end of the nuclear fuel cycle. These areas are (1) the single-cell concept, (2) the low-flow ventilation concept, (3) television viewing, (4) equipment-mounting racks, and (5) force-reflecting manipulation. These somewhat innovative directions are products of a design process where the technical scenario to be accomplished, the remote equipment to accomplish the scenario, and the facility design to house the equipment, are considered in an iterative design process to optimize performance, maximize long-term costs effectiveness, and minimize initial capital outlay. (author)

  15. Design concepts and advanced telerobotics development for facilities in the back end of the nuclear fuel cycle

    International Nuclear Information System (INIS)

    Feldman, M.J.

    1987-01-01

    In the Fuel Recycle Division at the Oak Ridge National Laboratory, a comprehensive remote systems development program has existed for the past seven years. The new remote technology under development is expected to significantly improve remote operations by extending the range of tasks accomplished by remote means and increasing the efficiency of remote work undertaken. Five areas of the development effort are primary contributors to the goal of higher operating efficiency for major facilities for the back end of the nuclear fuel cycle. These areas are the single-cell concept, the low-flow ventilation concept, television viewing, equipment-mounting racks, and force-reflecting manipulation. These somewhat innovative directions are products of a design process where the technical scenario to be accomplished, the remote equipment to accomplish the scenario, and the facility design to house the equipment, are considered in an iterative design process to optimize performance, maximize long-term costs effectiveness, and minimize initial capital outlay. 14 refs., 3 figs

  16. Off-design temperature effects on nuclear fuel pins for an advanced space-power-reactor concept

    Science.gov (United States)

    Bowles, K. J.

    1974-01-01

    An exploratory out-of-reactor investigation was made of the effects of short-time temperature excursions above the nominal operating temperature of 990 C on the compatibility of advanced nuclear space-power reactor fuel pin materials. This information is required for formulating a reliable reactor safety analysis and designing an emergency core cooling system. Simulated uranium mononitride (UN) fuel pins, clad with tungsten-lined T-111 (Ta-8W-2Hf) showed no compatibility problems after heating for 8 hours at 2400 C. At 2520 C and above, reactions occurred in 1 hour or less. Under these conditions free uranium formed, redistributed, and attacked the cladding.

  17. T-cell receptor (TCR) phenotype of nodal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (CTL): a clinicopathologic study of 39 cases.

    Science.gov (United States)

    Kato, Seiichi; Asano, Naoko; Miyata-Takata, Tomoko; Takata, Katsuyoshi; Elsayed, Ahmed Ali; Satou, Akira; Takahashi, Emiko; Kinoshita, Tomohiro; Nakamura, Shigeo

    2015-04-01

    Among Epstein-Barr virus (EBV)-positive cytotoxic T/NK-cell lymphoma, there are only a few reports on the clinicopathologic features of patients with primary nodal presentation (nodal EBV cytotoxic T-cell lymphoma [CTL]). Here, we compared the clinicopathologic profiles of 39 patients with nodal EBV CTL with those of 27 cases of "extranasal" NK/T-cell lymphoma of nasal type (ENKTL), especially addressing their T-cell receptor (TCR) phenotype. Histologically, 22 of 39 nodal EBV CTL cases (56%) were unique in having centroblastoid appearance, which was contrasted with the lower incidence of this feature in ENKTL (15%, P=0.001). In contrast, pleomorphic appearance was more frequently seen in ENKTL than in nodal EBV CTL (67% vs. 23%, P=0.001). Thirty-three of 39 nodal EBV CTL cases (85%) were of T-cell lineage on the basis of TCR expression and/or TCRγ gene rearrangement; in detail, 18 cases (46%) were TCRβ positive (αβ T), 5 (13%) were TCRγ and/or δ positive (γδ T), and 10 (26%) were TCR-silent type with clonal TCRγ gene rearrangement but no expression of TCRβ, γ, or δ. These results were clearly contrasted by a lower incidence of T-cell lineage in ENKTL (7 cases, 26%, P<0.001). Notably, the survival time of the 5 nodal lymphoma patients with γδ T-cell phenotype was within 3 months, which was inferior to those of αβ T and TCR-silent types (P=0.003), and 3 of those with available clinical information were all found to be associated with autoimmune diseases. These data suggest that nodal EBV CTL is distinct from ENKTL.

  18. An Approach for a Synthetic CTL Vaccine Design against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling

    Directory of Open Access Journals (Sweden)

    Edecio Cunha-Neto

    2017-06-01

    Full Text Available The threat posed by severe congenital abnormalities related to Zika virus (ZKV infection during pregnancy has turned development of a ZKV vaccine into an emergency. Recent work suggests that the cytotoxic T lymphocyte (CTL response to infection is an important defense mechanism in response to ZKV. Here, we develop the rationale and strategy for a new approach to developing cytotoxic T lymphocyte (CTL vaccines for ZKV flavivirus infection. The proposed approach is based on recent studies using a protein structure computer model for HIV epitope selection designed to select epitopes for CTL attack optimized for viruses that exhibit antigenic drift. Because naturally processed and presented human ZKV T cell epitopes have not yet been described, we identified predicted class I peptide sequences on ZKV matching previously identified DNV (Dengue class I epitopes and by using a Major Histocompatibility Complex (MHC binding prediction tool. A subset of those met the criteria for optimal CD8+ attack based on physical chemistry parameters determined by analysis of the ZKV protein structure encoded in open source Protein Data File (PDB format files. We also identified candidate ZKV epitopes predicted to bind promiscuously to multiple HLA class II molecules that could provide help to the CTL responses. This work suggests that a CTL vaccine for ZKV may be possible even if ZKV exhibits significant antigenic drift. We have previously described a microsphere-based CTL vaccine platform capable of eliciting an immune response for class I epitopes in mice and are currently working toward in vivo testing of class I and class II epitope delivery directed against ZKV epitopes using the same microsphere-based vaccine.

  19. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes

    DEFF Research Database (Denmark)

    Pérez, Carina L; Larsen, Mette Voldby; Gustafsson, Rasmus

    2008-01-01

    The genetic variations of the HIV-1 virus and its human host constitute major obstacles for obtaining potent HIV-1-specific CTL responses in individuals of diverse ethnic backgrounds infected with different HIV-1 variants. In this study, we developed and used a novel algorithm to select 184......, not previously described in the HIV-1 immunology database. In addition, we identified 21 "elite" epitopes that induced CTL responses in at least 4 of the 31 patients. A majority (27 of 31) of the study population recognized one or more of these highly immunogenic epitopes. We also found a limited set of 9...

  20. Advances in integrated and sustainable supply chain planning concepts, methods, tools and solution approaches toward a platform for industrial practice

    CERN Document Server

    Laínez-Aguirre, José Miguel

    2015-01-01

    Decision making at the enterprise level often encompass not only production operations and  product R&D, but other strategic functions such as financial planning and marketing. With the aim of maximizing growth and a firm’s value, companies often focus on co-ordinating these functional components as well as traditional hierarchical decision levels. Understanding this interplay can enhance enterprise capabilities of adaptation and response to uncertainties arising from internal processes as well as the external environment. This book presents concepts, methods, tools and solutions based on mathematical programming, which provides the quantitative support needed for integrated decision-making and ultimately for improving the allocation of overall corporate resources (e.g., materials, cash and personnel). Through a systems perspective, the integrated planning of the supply chain also promotes activities of reuse, reduction and recycling for achieving more sustainable environmental impacts of production/di...

  1. Concept - or no concept

    DEFF Research Database (Denmark)

    Thorsteinsson, Uffe

    1999-01-01

    Discussion about concept in industrial companies. A method for mapping of managerial concept in specific area is shown......Discussion about concept in industrial companies. A method for mapping of managerial concept in specific area is shown...

  2. MO-E-18C-04: Advanced Computer Simulation and Visualization Tools for Enhanced Understanding of Core Medical Physics Concepts

    International Nuclear Information System (INIS)

    Naqvi, S

    2014-01-01

    Purpose: Most medical physics programs emphasize proficiency in routine clinical calculations and QA. The formulaic aspect of these calculations and prescriptive nature of measurement protocols obviate the need to frequently apply basic physical principles, which, therefore, gradually decay away from memory. E.g. few students appreciate the role of electron transport in photon dose, making it difficult to understand key concepts such as dose buildup, electronic disequilibrium effects and Bragg-Gray theory. These conceptual deficiencies manifest when the physicist encounters a new system, requiring knowledge beyond routine activities. Methods: Two interactive computer simulation tools are developed to facilitate deeper learning of physical principles. One is a Monte Carlo code written with a strong educational aspect. The code can “label” regions and interactions to highlight specific aspects of the physics, e.g., certain regions can be designated as “starters” or “crossers,” and any interaction type can be turned on and off. Full 3D tracks with specific portions highlighted further enhance the visualization of radiation transport problems. The second code calculates and displays trajectories of a collection electrons under arbitrary space/time dependent Lorentz force using relativistic kinematics. Results: Using the Monte Carlo code, the student can interactively study photon and electron transport through visualization of dose components, particle tracks, and interaction types. The code can, for instance, be used to study kerma-dose relationship, explore electronic disequilibrium near interfaces, or visualize kernels by using interaction forcing. The electromagnetic simulator enables the student to explore accelerating mechanisms and particle optics in devices such as cyclotrons and linacs. Conclusion: The proposed tools are designed to enhance understanding of abstract concepts by highlighting various aspects of the physics. The simulations serve as

  3. MO-E-18C-04: Advanced Computer Simulation and Visualization Tools for Enhanced Understanding of Core Medical Physics Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Naqvi, S [Saint Agnes Cancer Institute, Department of Radiation Oncology, Baltimore, MD (United States)

    2014-06-15

    Purpose: Most medical physics programs emphasize proficiency in routine clinical calculations and QA. The formulaic aspect of these calculations and prescriptive nature of measurement protocols obviate the need to frequently apply basic physical principles, which, therefore, gradually decay away from memory. E.g. few students appreciate the role of electron transport in photon dose, making it difficult to understand key concepts such as dose buildup, electronic disequilibrium effects and Bragg-Gray theory. These conceptual deficiencies manifest when the physicist encounters a new system, requiring knowledge beyond routine activities. Methods: Two interactive computer simulation tools are developed to facilitate deeper learning of physical principles. One is a Monte Carlo code written with a strong educational aspect. The code can “label” regions and interactions to highlight specific aspects of the physics, e.g., certain regions can be designated as “starters” or “crossers,” and any interaction type can be turned on and off. Full 3D tracks with specific portions highlighted further enhance the visualization of radiation transport problems. The second code calculates and displays trajectories of a collection electrons under arbitrary space/time dependent Lorentz force using relativistic kinematics. Results: Using the Monte Carlo code, the student can interactively study photon and electron transport through visualization of dose components, particle tracks, and interaction types. The code can, for instance, be used to study kerma-dose relationship, explore electronic disequilibrium near interfaces, or visualize kernels by using interaction forcing. The electromagnetic simulator enables the student to explore accelerating mechanisms and particle optics in devices such as cyclotrons and linacs. Conclusion: The proposed tools are designed to enhance understanding of abstract concepts by highlighting various aspects of the physics. The simulations serve as

  4. Design Concepts, Fabrication and Advanced Characterization Methods of Innovative Piezoelectric Sensors Based on ZnO Nanowires

    Directory of Open Access Journals (Sweden)

    Rodolfo Araneo

    2014-12-01

    Full Text Available Micro- and nano-scale materials and systems based on zinc oxide are expected to explode in their applications in the electronics and photonics, including nano-arrays of addressable optoelectronic devices and sensors, due to their outstanding properties, including semiconductivity and the presence of a direct bandgap, piezoelectricity, pyroelectricity and biocompatibility. Most applications are based on the cooperative and average response of a large number of ZnO micro/nanostructures. However, in order to assess the quality of the materials and their performance, it is fundamental to characterize and then accurately model the specific electrical and piezoelectric properties of single ZnO structures. In this paper, we report on focused ion beam machined high aspect ratio nanowires and their mechanical and electrical (by means of conductive atomic force microscopy characterization. Then, we investigate the suitability of new power-law design concepts to accurately model the relevant electrical and mechanical size-effects, whose existence has been emphasized in recent reviews.

  5. Development of advanced material composites for use as internal insulation for LH2 tanks (gas layer concept)

    Science.gov (United States)

    Gille, J. P.

    1972-01-01

    A program is described that was conducted to develop an internal insulation system for potential application to the liquid hydrogen tanks of a reusable booster, where the tanks would be subjected to repeated high temperatures. The design of the internal insulation is based on a unique gas layer concept, in which capillary or surface tension effects are used to maintain a stable gas layer, within a cellular core structure, between the tank wall and the contained liquid hydrogen. Specific objectives were to select materials for insulation systems that would be compatible with wall temperatures of 350 F and 650 F during reentry into the earth's atmosphere, and to fabricate and test insulation systems under conditions simulating the operating environment. A materials test program was conducted to evaluate the properties of candidate materials at elevated temperatures and at the temperature of liquid hydrogen, and to determine the compatibility of the materials with a hydrogen atmosphere at the appropriate elevated temperature. The materials that were finally selected included Kapton polyimide films, silicone adhesives, fiber glass batting, and in the case of the 350 F system, Teflon film.

  6. Accident analysis for new reactor concepts and VVER type reactor design with advanced fuel. STC with Russia. Final report

    International Nuclear Information System (INIS)

    Grundmann, U.; Kliem, S.; Mittag, S.; Rohde, U.; Seidel, A.

    2000-10-01

    In the frame of a project on scientific-technical cooperation funded by BMBF/BMWi, the 3D reactor dynamics code DYN3D developed at Forschungszentrum Rossendorf (FZR), has been transferred to the Institute of Physics and Power Engineering (IPPE) Obninsk in Russia and integrated into the software package of IPPE. DYN3D has been coupled to a thermohydraulic system code used in IPPE making available 3D neutron kinetics within this software package. A new macroscopic cross section library has been created using a modified version of the WIMS/D4 code. This library includes data for modernized fuel design containing burnable absorbers in different concentrations, which is tested in VVER-1000 type reactors. The cross section library has been connected to DYN3D. Calculations were performed to check the library in comparison with other data libraries and codes. The code DYN3D and the coupled 3D neutron kinetics/thermal hydraulics code system were used to perform analyses of Anticipated Transients Without Scram (ATWS) for the reactor design ABV-67, an integral reactor concept with small power developed under participation of IPPE. The fluid dynamics code DINCOR developed at IPPE was transferred to FZR. It was used in validation calculations on test problems for the short-term core melt behaviour (CORVIS experiments). (orig.) [de

  7. Practical implementation of the concept of converted electric vehicle with advanced traction and dynamic performance and environmental safety indicators

    Science.gov (United States)

    Sidorov, K. M.; Yutt, V. E.; Grishchenko, A. G.; Golubchik, T. V.

    2018-02-01

    The objective of the work presented in this paper is to describe the implementation of the technical solutions have been developed, with regard to structure, composition, and characteristics, for an experimental prototype of an electric vehicle which has been converted from a conventional vehicle. The methodology of the study results is based on the practical implementation of the developed concept of the conversion of conventional vehicles into electric vehicles. The main components of electric propulsion system of the experimental prototype of electric vehicle are developed and manufactured on the basis of computational researches, taking into account the criteria and principles of conversion within the framework of presented work. The article describes a schematic and a design of power conversion and commutation electrical equipment, traction battery, electromechanical transmission. These results can serve as guidance material in the design and implementation of electric propulsion system (EPS) components of electric vehicles, facilitate the development of optimal technical solutions in the development and manufacture of vehicles, including those aimed at autonomy of operation and the use of perspective driver assistance systems. As part of this work, was suggested a rational structure for an electric vehicle experimental prototype, including technical performance characteristics of the components of EPS.

  8. Large-Scale Liquid Hydrogen Tank Rapid Chill and Fill Testing for the Advanced Shuttle Upper Stage Concept

    Science.gov (United States)

    Flachbart, R. H.; Hedayat, A.; Holt, K. A.; Sims, J.; Johnson, E. F.; Hastings, L. J.; Lak, T.

    2013-01-01

    Cryogenic upper stages in the Space Shuttle program were prohibited primarily due to a safety risk of a 'return to launch site' abort. An upper stage concept addressed this concern by proposing that the stage be launched empty and filled using shuttle external tank residuals after the atmospheric pressure could no longer sustain an explosion. However, only about 5 minutes was allowed for tank fill. Liquid hydrogen testing was conducted within a near-ambient environment using the multipurpose hydrogen test bed 638.5 ft3 (18m3) cylindrical tank with a spray bar mounted longitudinally inside. Although the tank was filled within 5 minutes, chilldown of the tank structure was incomplete, and excessive tank pressures occurred upon vent valve closure. Elevated tank wall temperatures below the liquid level were clearly characteristic of film boiling. The test results have substantial implications for on-orbit cryogen transfer since the formation of a vapor film would be much less inhibited due to the reduced gravity. However, the heavy tank walls could become an asset in normal gravity testing for on-orbit transfer, i.e., if film boiling in a nonflight weight tank can be inhibited in normal gravity, then analytical modeling anchored with the data could be applied to reduced gravity environments with increased confidence.

  9. An Advanced Sodium-Cooled Fast Reactor Core Concept Using Uranium-Free Metallic Fuels for Maximizing TRU Burning Rate

    Directory of Open Access Journals (Sweden)

    Wuseong You

    2017-12-01

    Full Text Available In this paper, we designed and analyzed advanced sodium-cooled fast reactor cores using uranium-free metallic fuels for maximizing burning rate of transuranics (TRU nuclides from PWR spent fuels. It is well known that the removal of fertile nuclides such as 238U from fuels in liquid metal cooled fast reactor leads to the degradation of important safety parameters such as the Doppler coefficient, coolant void worth, and delayed neutron fraction. To resolve the degradation of the Doppler coefficient, we considered adding resonant nuclides to the uranium-free metallic fuels. The analysis results showed that the cores using uranium-free fuels loaded with tungsten instead of uranium have a significantly lower burnup reactivity swing and more negative Doppler coefficients than the core using uranium-free fuels without resonant nuclides. In addition, we considered the use of axially central B4C absorber region and moderator rods to further improve safety parameters such as sodium void worth, burnup reactivity swing, and the Doppler coefficient. The results of the analysis showed that the final design core can consume ~353 kg per cycle and satisfies self-controllability under unprotected accidents. The fuel cycle analysis showed that the PWR–SFR coupling fuel cycle option drastically reduces the amount of waste going to repository and the SFR burner can consume the amount of TRUs discharged from 3.72 PWRs generating the same electricity.

  10. An Advanced TALSPEAK Concept for Separating Minor Actinides. Part 2. Flowsheet Test with Actinide-spiked Simulant

    Energy Technology Data Exchange (ETDEWEB)

    Wilden, Andreas [Forschungszentrum Jülich GmbH, Institut für Energie – und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany; Lumetta, Gregg J. [Nuclear Science and Engineering Group, Pacific Northwest National Laboratory, Richland, DC, USA; Sadowski, Fabian [Forschungszentrum Jülich GmbH, Institut für Energie – und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany; Schmidt, Holger [Forschungszentrum Jülich GmbH, Institut für Energie – und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany; Schneider, Dimitri [Forschungszentrum Jülich GmbH, Institut für Energie – und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany; Gerdes, Markus [Forschungszentrum Jülich GmbH, Institut für Energie – und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany; Law, Jack D. [Aqueous Separations and Radiochemistry Department, Idaho National Laboratory, Idaho Falls, ID, USA; Geist, Andreas [Karlsruhe Institute of Technology (KIT), Institute for Nuclear Waste Disposal (INE), Karlsruhe, Germany; Bosbach, Dirk [Forschungszentrum Jülich GmbH, Institut für Energie – und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany; Modolo, Giuseppe [Forschungszentrum Jülich GmbH, Institut für Energie – und Klimaforschung – Nukleare Entsorgung und Reaktorsicherheit (IEK-6), Jülich, Germany

    2017-08-17

    A solvent extraction system has been developed for separating trivalent actinides from lanthanides. This “Advanced TALSPEAK” system uses 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester to extract the lanthanides into a n-dodecane-based solvent phase, while the actinides are retained in a citrate-buffered aqueous phase by complexation to N-(2-hydroxyethyl)ethylenediamine-N,N',N'-triacetic acid. Batch distribution measurements indicate that the separation of americium from the light lanthanides decreases as the pH decreases. For example, the separation factor between La and Am increases from 2.5 at pH 2.0 to 19.3 at pH 3.0. However, previous investigations indicated that the extraction rates for the heavier lanthanides decrease with increasing pH. So, a balance between these two competing effects is required. An aqueous phase in which the pH was set at 2.6 was chosen for further process development because this offered optimal separation, with a minimum separation factor of ~8.4, based on the separation between La and Am. Centrifugal contactor single-stage efficiencies were measured to characterize the performance of the system under flow conditions.

  11. Novel CTL epitopes identified through a Y. pestis proteome-wide analysis in the search for vaccine candidates against plague.

    Science.gov (United States)

    Zvi, Anat; Rotem, Shahar; Zauberman, Ayelet; Elia, Uri; Aftalion, Moshe; Bar-Haim, Erez; Mamroud, Emanuelle; Cohen, Ofer

    2017-10-20

    The causative agent of Plague, Yersinia pestis, is a highly virulent pathogen and a potential bioweapon. Depending on the route of infection, two prevalent occurrences of the disease are known, bubonic and pneumonic. The latter has a high fatality rate. In the absence of a licensed vaccine, intense efforts to develop a safe and efficacious vaccine have been conducted, and humoral-driven subunit vaccines containing the F1 and LcrV antigens are currently under clinical trials. It is well known that a cellular immune response might have an essential additive value to immunity and protection against Y. pestis infection. Nevertheless, very few documented epitopes eliciting a protective T-cell response have been reported. Here, we present a combined high throughput computational and experimental effort towards identification of CD8 T-cell epitopes. All 4067 proteins of Y. pestis were analyzed with state-of-the-art recently developed prediction algorithms aimed at mapping potential MHC class I binders. A compilation of the results obtained from several prediction methods revealed a total of 238,000 peptide candidates, which necessitated downstream filtering criteria. Our previously established and proven approach for enrichment of true positive CTL epitopes, which relies on mapping clusters rich in tandem or overlapping predicted MHC binders ("hotspots"), was applied, as well as considerations of predicted binding affinity. A total of 1532 peptides were tested for their ability to elicit a specific T-cell response by following the production of IFNγ from splenocytes isolated from vaccinated mice. Altogether, the screen resulted in 178 positive responders (11.8%), all novel Y. pestis CTL epitopes. These epitopes span 113 Y. pestis proteins. Substantial enrichment of membrane-associated proteins was detected for epitopes selected from hotspots of predicted MHC binders. These results considerably expand the repertoire of known CTL epitopes in Y. pestis and pave the way to

  12. Scaling Studies for Advanced High Temperature Reactor Concepts, Final Technical Report: October 2014—December 2017

    Energy Technology Data Exchange (ETDEWEB)

    Woods, Brian; Gutowska, Izabela; Chiger, Howard

    2018-03-26

    Computer simulations of nuclear reactor thermal-hydraulic phenomena are often used in the design and licensing of nuclear reactor systems. In order to assess the accuracy of these computer simulations, computer codes and methods are often validated against experimental data. This experimental data must be of sufficiently high quality in order to conduct a robust validation exercise. In addition, this experimental data is generally collected at experimental facilities that are of a smaller scale than the reactor systems that are being simulated due to cost considerations. Therefore, smaller scale test facilities must be designed and constructed in such a fashion to ensure that the prototypical behavior of a particular nuclear reactor system is preserved. The work completed through this project has resulted in scaling analyses and conceptual design development for a test facility capable of collecting code validation data for the following high temperature gas reactor systems and events— 1. Passive natural circulation core cooling system, 2. pebble bed gas reactor concept, 3. General Atomics Energy Multiplier Module reactor, and 4. prismatic block design steam-water ingress event. In the event that code validation data for these systems or events is needed in the future, significant progress in the design of an appropriate integral-type test facility has already been completed as a result of this project. Where applicable, the next step would be to begin the detailed design development and material procurement. As part of this project applicable scaling analyses were completed and test facility design requirements developed. Conceptual designs were developed for the implementation of these design requirements at the Oregon State University (OSU) High Temperature Test Facility (HTTF). The original HTTF is based on a ¼-scale model of a high temperature gas reactor concept with the capability for both forced and natural circulation flow through a prismatic core with

  13. Antimelanoma CTL recognizes peptides derived from an ORF transcribed from the antisense strand of the 3′ untranslated region of TRIT1

    Directory of Open Access Journals (Sweden)

    Rolf K Swoboda

    2014-01-01

    Full Text Available Noncoding regions of the genome play an important role in tumorigenesis of cancer. Using expression cloning, we have identified a cytotoxic T lymphocyte (CTL–defined antigen that recognizes a protein sequence derived from an open reading frame transcribed from the reverse strand in the 3′ untranslated region of tRNA isopentenyltransferase 1 (TRIT1. A peptide derived from this open reading frame (ORF sequence and predicted to bind to HLA-B57, sensitized HLA-B57+ tumor cells to lysis by CTL793. The peptide also induced a CTL response in peripheral blood mononuclear cells (PBMC of patient 793 and in two other melanoma patients. The CTL lysed peptide-pulsed HLA-B57+ target cells and melanoma cells with endogenous antigen expression. The recognition of this antigen is not limited to HLA-B57-restricted CTLs. An HLA-A2 peptide derived from the ORF was able to induce CTLs in PBMC of 2 HLA-A2+ patients. This study describes for the first time a CTL-defined melanoma antigen that is derived from an ORF on the reverse strand of the putative tumor suppressor gene TRIT1. This antigen has potential use as a vaccine or its ability to induce CTLs in vitro could be used as a predictive biomarker.

  14. Detection of choline transporter-like 1 protein CTL1 in neuroblastoma × glioma cells and in the CNS, and its role in choline uptake

    Czech Academy of Sciences Publication Activity Database

    Machová, Eva; O´Regan, S.; Newcombe, J.; Meunier, F. M.; Prentice, J.; Dove, R.; Lisá, Věra; Doležal, Vladimír

    2009-01-01

    Roč. 110, č. 4 (2009), s. 1297-1309 ISSN 0022-3042 R&D Projects: GA MŠk(CZ) LC554; GA AV ČR(CZ) IAA500110703 Institutional research plan: CEZ:AV0Z50110509 Keywords : CTL1 * choline * cell growth Subject RIV: ED - Physiology Impact factor: 3.999, year: 2009

  15. Model Pembelajaran CTL (Contextual Teaching and Learning dalam Meningkatkan Hasil Belajar Mahasiswa PGSD Pada MataKuliah Konsep IPS Dasar

    Directory of Open Access Journals (Sweden)

    Wahyu Susiloningsih

    2016-03-01

    Full Text Available Hasil belajar adalah suatu proses perubahan tingkah laku dalam pengetahuan, sikap, dan ketrampilan yang diperoleh dalam jangka waktu yang lama.Mata kuliah Konsep IPS Dasar merupakan mata kuliah yang memberikan pemahaman kepada mahasiswa PGSD tentang konsep dasar IPS sebagai landasan kajian yang bahannya bersumber dari kehidupan manusia di masyarakat, yang aspek-aspeknya meliputi social science (ilmu sosial, social studies (studi sosial, Ilmu Pengetahuan Sosial (IPS. IPS merupakan pembelajaran pada tingkat sekolah yang berperan mengfungsionalkan ilmu-ilmu sosial yang bersifat teoritik dalam kehidupan nyata dalam masyarakat. Model pembelajaran CTL adalah model pembelajaran yang menuntut kreatifitas guru dalam mengaitkan subject matter dengan kehidupan nyata mahasiswa guna membantu mahasiswa untuk lebih mudah memaknai materi tersebut.

  16. PEMBELAJARAN PENJUMLAHAN BILANGAN PECAHAN DENGAN METODE CONTEXTUAL TEACHING AND LEARNING (CTL DI SD MUHAMMADIYAH PROGRAM KHUSUS, KOTA BARAT, SURAKARTA

    Directory of Open Access Journals (Sweden)

    Yulia Maftuhah Hidayati

    2015-07-01

    Full Text Available This study is aimed to describe the lesson plan, teaching learning process of sum of fractions based of Contextual Teaching and Learning (CTL, and the motivation of learners attend classes in learning. This study used a qualitative approach. The type of research is a case study. Validation of data is done through triangulation. Data were collected through interviews, observation, documentation, and testing. The technique of data analysis is descriptive, entrepretative. The results of this study indicate that (1 the development of lesson plan has been implemented routinely in every new school year, (2 the process of learning mathematics goes through three stages, namely preinstructional phase (preliminary / initial activity, instructional phase (core activities, and appraisal, (3 during the learning process, the students have a high motivation to participate in activities  because of the method used by teachers is fun and enjoyable

  17. Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors

    DEFF Research Database (Denmark)

    Andersen, Rikke Sick; Sørensen, Rikke Bæk; Ritter, Cathrin

    2011-01-01

    . Furthermore, blood from cancer patients and healthy donors was screened for spontaneous T-cell reactivity against the peptide in IFN-γ ELISPOT assays. Patients with breast cancer, malignant melanoma, or renal cell carcinoma hosted powerful and high-frequency T-cell responses against the peptide. In addition......, when blood from healthy donors was tested, similar responses were observed. Ultimately, serum from cancer patients and healthy donors was analyzed for anti-cyclin B1 antibodies. Humoral responses against cyclin B1 were frequently detected in both cancer patients and healthy donors. In conclusion......, a high-affinity cyclin B1-derived HLA-A2-restricted CTL epitope was identified, which was presented on the cell surface of cancer cells, and elicited spontaneous T-cell responses in cancer patients and healthy donors....

  18. Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors

    DEFF Research Database (Denmark)

    Andersen, Rikke Sick; Sørensen, Rikke Bæk; Ritter, Cathrin

    2011-01-01

    . Furthermore, blood from cancer patients and healthy donors was screened for spontaneous T-cell reactivity against the peptide in IFN-¿ ELISPOT assays. Patients with breast cancer, malignant melanoma, or renal cell carcinoma hosted powerful and high-frequency T-cell responses against the peptide. In addition......, when blood from healthy donors was tested, similar responses were observed. Ultimately, serum from cancer patients and healthy donors was analyzed for anti-cyclin B1 antibodies. Humoral responses against cyclin B1 were frequently detected in both cancer patients and healthy donors. In conclusion......, a high-affinity cyclin B1-derived HLA-A2-restricted CTL epitope was identified, which was presented on the cell surface of cancer cells, and elicited spontaneous T-cell responses in cancer patients and healthy donors....

  19. Image and laparoscopic guided interstitial brachytherapy for locally advanced primary or recurrent gynaecological cancer using the adaptive GEC ESTRO target concept

    International Nuclear Information System (INIS)

    Fokdal, Lars; Tanderup, Kari; Nielsen, Soren Kynde; Christensen, Henrik Kidmose; Rohl, Lisbeth; Pedersen, Erik Morre; Schonemann, Niels Kim; Lindegaard, Jacob Christian

    2011-01-01

    Purpose: To retrospectively assess treatment outcome of image and laparoscopic guided interstitial pulsed dose rate brachytherapy (PDR-BT) for locally advanced gynaecological cancer using the adaptive GEC ESTRO target concept. Materials and methods: Between June 2005 and December 2010, 28 consecutive patients were treated for locally advanced primary vaginal (nine), recurrent endometrial (12) or recurrent cervical cancer (seven) with combined external beam radiotherapy (EBRT) and interstitial PDR-BT. Treatment was initiated with whole pelvic EBRT to a median dose of 45 Gy followed by PDR-BT using the Martinez Universal Perineal Interstitial Template (MUPIT). All implants were virtually preplanned using MRI of the pelvis with a dummy MUPIT in situ. The GEC ESTRO high risk clinical target volume (HR CTV), intermediate risk clinical target volume (IR CTV) and the organs at risk (OAR) were contoured and a preplan for implantation was generated (BrachyVision, Varian). The subsequent implantation was performed under laparoscopic visualisation. Final contouring and treatment planning were done using a post-implant CT. Planning aim of PDR-BT was to deliver 30 Gy in 50 hourly pulses to HR CTV. Manual dose optimisation was performed with the aim of reaching a D90 > 80 Gy in the HR CTV calculated as the total biologically equivalent to 2 Gy fractions of EBRT and BT (EQD2). Dose to the OAR were evaluated using dose volume constraints for D 2cc of 90 Gy for bladder and 70 Gy for rectum and sigmoid. Results: For HR CTV the median volume was 26 cm 3 (7-91 cm 3 ). Coverage of the HR CTV was 97% (90-100%) and D90 was 82 Gy (77-88 Gy). The D 2cc for bladder, rectum, and sigmoid were 65 Gy (47-81 Gy), 61 Gy (50-77 Gy), and 52 Gy (44-68 Gy), respectively. Median follow up was 18 months (6-61 months). The actuarial 2 years local control rate was 92% (SE 5), while disease-free survival and overall survival were 59% (SE 11) and 74%, respectively (SE 10). No complications to the

  20. Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques.

    Directory of Open Access Journals (Sweden)

    Thomas H Vanderford

    2011-05-01

    Full Text Available SIV(mac239 infection of rhesus macaques (RMs results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV mutants, we longitudinally assessed the presence of CTL escape variants in two MamuA*01-restricted immunodominant epitopes (Tat-SL8 and Gag-CM9 in the plasma, PBMCs, lymph nodes (LN, and rectal biopsies (RB of fifteen SIV(mac239-infected RMs. As expected, Gag-CM9 did not exhibit signs of escape before day 84 post infection. In contrast, Tat-SL8 escape mutants were apparent in all tissues by day 14 post infection. Interestingly LNs and plasma exhibited the highest level of escape at day 14 and day 28 post infection, respectively, with the rate of escape in the RB remaining lower throughout the acute infection. The possibility that CTL escape occurs in LNs before RBs is confirmed by the observation that the specific mutants found at high frequency in LNs at day 14 post infection became dominant at day 28 post infection in plasma, PBMC, and RB. Finally, the frequency of escape mutants in plasma at day 28 post infection correlated strongly with the level Tat-SL8-specific CD8 T cells in the LN and PBMC at day 14 post infection. These results indicate that LNs represent the primary source of CTL escape mutants during the acute phase of SIV(mac239 infection, suggesting that LNs are the main anatomic sites of virus replication and/or the tissues in which CTL pressure is most effective in selecting SIV escape variants.

  1. PENERAPAN CTL (CONTEXTUAL TEACHING AND LEARNING MENGGUNAKAN MEDIA AJAR KLIPING UNTUK MENINGKATKAN PRESTASI BELAJAR, KOMPETENSI DASAR "MENEMUKAN PELUANG BARU DARI PELANGGAN" KELAS XI PEMASARAN SMK N 1 JAPARA KABUPATEN KUNINGAN

    Directory of Open Access Journals (Sweden)

    Marlina

    2012-05-01

    -rata skor sebesar 66,45 dan termasuk dalam kategori rendah. Tes siklus II menunjukkan skor rata-rata sebesar 73,71 dan termasuk dalam kategori tinggi. Jadi, telah terjadi peningkatan dari siklus I ke siklus II sebesar 7,3 atau sebesar 10,9%. Perolehan hasil ini menunjukkan bahwa pembelajaran kompetensi dasar menemukan peluang baru dari pelanggan dengan model pembelajaran Kontekstual berbantuan media kliping telah berhasil. CTL is a concept of learning in which the teachers bring a real world situations in the classroom and encourage the students to make connections between the knowledge that they have and its application in the life, while the students gain the knowledge bit by bit, and from the process of constructing themselves, as a basis to solve problems in their life. From the result of the first observation class XI Marketing SMK Negeri 1 Japara, obtained that on the implementation of learning basic competence discovering New Opportunities from customers was less developed, it was because the learning process only occured in one direction or focused only on the teacher, namely, using conventional learning, while the average value of the midterm test of academic year 2010 was 60.32 where there were 14 students whose values ??did not meet the Criteria of Minimum Completeness (KKM. The Problem in this study is "What is CTL learning Model (Contextual Teaching Learning assisted clippings media can improve student learning achievement on basic competence discovering new opportunities from customer class XI Marketing SMK Negeri 1 Japara?". The purpose of this study is to find out the effectiveness of clippings media with CTL learning model to improve student leaning achievement of basic competence discovering new opportunities from customers Class XI Marketing SMK Negeri 1 Japara Kuningan District. The subject of this study is the student of SMK Negeri 1 Japara that consists of �2 male students and 29 female students. The study is done in 2 cycles, namely, cycle I and

  2. Application of advanced validation concepts to oxide fuel performance codes: LIFE-4 fast-reactor and FRAPCON thermal-reactor fuel performance codes

    Energy Technology Data Exchange (ETDEWEB)

    Unal, C., E-mail: cu@lanl.gov [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States); Williams, B.J. [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States); Yacout, A. [Argonne National Laboratory, 9700 S. Cass Avenue, Lemont, IL 60439 (United States); Higdon, D.M. [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States)

    2013-10-15

    /validation of MS/MP capabilities because these advanced tools have not yet reached sufficient maturity to support such an investigation. In an earlier paper (Unal et al., 2011), we proposed a methodology that potentially can be used to address these new challenges in the design and licensing of evolving nuclear technology. The main components of the proposed methodology are verification, validation, calibration, and uncertainty quantification. An enhanced calibration concept was introduced and is accomplished through data assimilation. Since advanced MS/MP codes have not yet reached the level of maturity required for a comprehensive validation and calibration exercise, we considered two legacy fuel codes and apply parts of our methodology to these codes to demonstrate the benefits of the new calibration capabilities we recently developed as a part of the proposed framework. This effort does not directly support “born-assessed” validation for advanced MS/MP codes, but is useful to gain insight on legacy modeling deficiencies and to guide and develop recommendations on high and low priority directions for development of advanced codes and advanced experiments, so as to maximize the benefits of advanced validation and uncertainty quantification (VU) efforts involving the next generation of MS/MP code capabilities. This paper discusses the application of advanced validation techniques (sensitivity, calibration, and prediction) to nuclear fuel performance codes FRAPCON (Geelhood et al., 2011a,b) and LIFE-4 (Boltax et al., 1990). FRAPCON is used to predict oxide fuel behavior in light water reactors. LIFE-4 was developed in the 1980s to predict oxide fuel behavior in fast reactors. We introduce a sensitivity ranking methodology to narrow down the selected parameters for follow-up sensitivity and calibration analyses. We use screening methods with both codes and discuss the results. The number of selected modeling parameters was 61 for FRAPCON and 69 for LIFE-4. The screening

  3. The Application of the NASA Advanced Concepts Office, Launch Vehicle Team Design Process and Tools for Modeling Small Responsive Launch Vehicles

    Science.gov (United States)

    Threet, Grady E.; Waters, Eric D.; Creech, Dennis M.

    2012-01-01

    The Advanced Concepts Office (ACO) Launch Vehicle Team at the NASA Marshall Space Flight Center (MSFC) is recognized throughout NASA for launch vehicle conceptual definition and pre-phase A concept design evaluation. The Launch Vehicle Team has been instrumental in defining the vehicle trade space for many of NASA s high level launch system studies from the Exploration Systems Architecture Study (ESAS) through the Augustine Report, Constellation, and now Space Launch System (SLS). The Launch Vehicle Team s approach to rapid turn-around and comparative analysis of multiple launch vehicle architectures has played a large role in narrowing the design options for future vehicle development. Recently the Launch Vehicle Team has been developing versions of their vetted tools used on large launch vehicles and repackaged the process and capability to apply to smaller more responsive launch vehicles. Along this development path the LV Team has evaluated trajectory tools and assumptions against sounding rocket trajectories and air launch systems, begun altering subsystem mass estimating relationships to handle smaller vehicle components, and as an additional development driver, have begun an in-house small launch vehicle study. With the recent interest in small responsive launch systems and the known capability and response time of the ACO LV Team, ACO s launch vehicle assessment capability can be utilized to rapidly evaluate the vast and opportune trade space that small launch vehicles currently encompass. This would provide a great benefit to the customer in order to reduce that large trade space to a select few alternatives that should best fit the customer s payload needs.

  4. DUAL-MODE PROPULSION SYSTEM ENABLING CUBESAT EXPLORATION OF THE SOLAR SYSTEM NASA Innovative Advanced Concepts (NIAC) Phase I Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Nathan Jerred; Troy Howe; Adarsh Rajguru; Dr. Steven Howe

    2014-06-01

    -based systems. The second scenario allows for the production of electrical power, which is then available for electric-based propulsion. Additionally, once at location the production of electrical power can be dedicated to the payload’s communication system for data transfer. Ultimately, the proposed dual-mode propulsion platform capitalizes on the benefits of two types of propulsion methods – the thrust of thermal propulsion ideal for quick orbital maneuvers and the specific impulse of electric propulsion ideal for efficient inter-planetary travel. Previous versions of this RTR-based concept have been studied for various applications [NETS 1-3]. The current version of this concept is being matured through a NASA Innovative Advanced Concepts (NIAC) Phase I grant, awarded for FY 2014. In this study the RTR concept is being developed to deliver a 6U CubeSat payload to the orbit of the Saturnian moon - Enceladus. Additionally, this study will develop an entire mission architecture for Enceladus targeting a total allowable launch mass of 1,000 kg.

  5. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice

    DEFF Research Database (Denmark)

    Thomsen, Allan Randrup; Johansen, J; Marker, O

    1996-01-01

    To study the contribution of CD4+ T cells and B cells to antiviral immunity and long term virus control, MHC class II-deficient and B cell-deficient mice were infected with lymphocytic choriomeningitis virus. In class II-deficient mice, which lack CD4+ T cells, the primary CTL response is virtually...... this phenomenon could reflect participation of B cells and/or Abs in long term virus control, similar experiments were performed with mice that do not have mature B cells because of a disrupted membrane exon of the mu chain gene. In these mice, the cell-mediated immune response was slightly delayed, but transient...... and that in their absence, the virus-specific CTL potential becomes exhausted. Together our results indicate that while CD8+ cells play a dominant role in acute virus control, all three major components of the immune system are required for long term virus control....

  6. Transgene IL-6 Enhances DC-Stimulated CTL Responses by Counteracting CD4+25+Foxp3+ Regulatory T Cell Suppression via IL-6-Induced Foxp3 Downregulation

    Directory of Open Access Journals (Sweden)

    Kalpana Kalyanasundaram Bhanumathy

    2014-03-01

    Full Text Available Dendritic cells (DCs, the most potent antigen-presenting cells have been extensively applied in clinical trials for evaluation of antitumor immunity. However, the efficacy of DC-mediated cancer vaccines is still limited as they are unable to sufficiently break the immune tolerance. In this study, we constructed a recombinant adenoviral vector (AdVIL-6 expressing IL-6, and generated IL-6 transgene-engineered DC vaccine (DCOVA/IL-6 by transfection of murine bone marrow-derived ovalbumin (OVA-pulsed DCs (DCOVA with AdVIL-6. We then assessed DCOVA/IL-6-stimulated cytotoxic T-lymphocyte (CTL responses and antitumor immunity in OVA-specific animal tumor model. We demonstrate that DCOVA/IL-6 vaccine up-regulates expression of DC maturation markers, secretes transgene-encoded IL-6, and more efficiently stimulates OVA-specific CTL responses and therapeutic immunity against OVA-expressing B16 melanoma BL6-10OVA in vivo than the control DCOVA/Null vaccine. Moreover, DCOVA/IL-6-stimulated CTL responses were relatively maintained in mice with transfer of CD4+25+Foxp3+ Tr-cells, but significantly reduced when treated with anti-IL-6 antibody. In addition, we demonstrate that IL-6 down-regulates Foxp3-expression of CD4+25+Foxp3+ Tr-cells in vitro. Taken together, our results demonstrate that AdV-mediated IL-6 transgene-engineered DC vaccine stimulates potent CTL responses and antitumor immunity by counteracting CD4+25+ Tr immunosuppression via IL-6-induced Foxp3 down-regulation. Thus, IL-6 may be a good candidate for engineering DCs for cancer immunotherapy.

  7. Expression, refolding and preliminary X-ray crystallographic analysis of equine MHC class I molecule complexed with an EIAV-Env CTL epitope

    International Nuclear Information System (INIS)

    Yao, Shugang; Qi, Jianxun; Liu, Jun; Chen, Rong; Pan, Xiaocheng; Li, Xiaoying; Gao, Feng; Xia, Chun

    2011-01-01

    The equine MHC class I molecule was crystallized in complex with β 2 -microglobulin and a CTL epitope and X-ray diffraction data were collected to 2.3 Å resolution. In order to clarify the structure and the peptide-presentation characteristics of the equine major histocompatibility complex (MHC) class I molecule, a complex of equine MHC class I molecule (ELA-A1 haplotype, 7-6 allele) with mouse β 2 -microglobulin and the cytotoxic T lymphocyte (CTL) epitope Env-RW12 (RVEDVTNTAEYW) derived from equine infectious anaemia virus (EIAV) envelope protein (residues 195–206) was refolded and crystallized. The crystal, which belonged to space group P2 1 , diffracted to 2.3 Å resolution and had unit-cell parameters a = 82.5, b = 71.4, c = 99.8 Å, β = 102.9°. The crystal structure contained two molecules in the asymmetric unit. These results should help to determine the first equine MHC class I molecule structure presenting an EIAV CTL epitope

  8. Kinetics of HIV-1 CTL epitopes recognized by HLA I alleles in HIV-infected individuals at times near primary infection: the Provir/Latitude45 study.

    Directory of Open Access Journals (Sweden)

    Jennifer Papuchon

    Full Text Available In patients responding successfully to ART, the next therapeutic step is viral cure. An interesting strategy is antiviral vaccination, particularly involving CD8 T cell epitopes. However, attempts at vaccination are dependent on the immunogenetic background of individuals. The Provir/Latitude 45 project aims to investigate which CTL epitopes in proviral HIV-1 will be recognized by the immune system when HLA alleles are taken into consideration. A prior study (Papuchon et al, PLoS ONE 2013 showed that chronically-infected patients under successful ART exhibited variations of proviral CTL epitopes compared to a reference viral strain (HXB2 and that a generic vaccine may not be efficient. Here, we investigated viral and/or proviral CTL epitopes at different time points in recently infected individuals of the Canadian primary HIV infection cohort and assessed the affinity of these epitopes for HLA alleles during the study period. An analysis of the results confirms that it is not possible to fully predict which epitopes will be recognized by the HLA alleles of the patients if the reference sequences and epitopes are taken as the basis of simulation. Epitopes may be seen to vary in circulating RNA and proviral DNA. Despite this confirmation, the overall variability of the epitopes was low in these patients who are temporally close to primary infection.

  9. Kinetics of HIV-1 CTL epitopes recognized by HLA I alleles in HIV-infected individuals at times near primary infection: the Provir/Latitude45 study.

    Science.gov (United States)

    Papuchon, Jennifer; Pinson, Patricia; Guidicelli, Gwenda-Line; Bellecave, Pantxika; Thomas, Réjean; LeBlanc, Roger; Reigadas, Sandrine; Taupin, Jean-Luc; Baril, Jean Guy; Routy, Jean Pierre; Wainberg, Mark; Fleury, Hervé

    2014-01-01

    In patients responding successfully to ART, the next therapeutic step is viral cure. An interesting strategy is antiviral vaccination, particularly involving CD8 T cell epitopes. However, attempts at vaccination are dependent on the immunogenetic background of individuals. The Provir/Latitude 45 project aims to investigate which CTL epitopes in proviral HIV-1 will be recognized by the immune system when HLA alleles are taken into consideration. A prior study (Papuchon et al, PLoS ONE 2013) showed that chronically-infected patients under successful ART exhibited variations of proviral CTL epitopes compared to a reference viral strain (HXB2) and that a generic vaccine may not be efficient. Here, we investigated viral and/or proviral CTL epitopes at different time points in recently infected individuals of the Canadian primary HIV infection cohort and assessed the affinity of these epitopes for HLA alleles during the study period. An analysis of the results confirms that it is not possible to fully predict which epitopes will be recognized by the HLA alleles of the patients if the reference sequences and epitopes are taken as the basis of simulation. Epitopes may be seen to vary in circulating RNA and proviral DNA. Despite this confirmation, the overall variability of the epitopes was low in these patients who are temporally close to primary infection.

  10. Human dendritic cells sequentially matured with CD4+ T cells as a secondary signal favor CTL and long-term T memory cell responses

    Directory of Open Access Journals (Sweden)

    Thomas Simon

    2012-01-01

    Full Text Available Dendritic cells (DCs are professional antigen-presenting cells involved in the control and initiation of immune responses. In vivo, DCs exposed at the periphery to maturation stimuli migrate to lymph nodes, where they receive secondary signals from CD4+ T helper cells. These DCs become able to initiate CD8+ cytotoxic T lymphocyte (CTL responses. However, in vitro investigations concerning human monocyte-derived DCs have never focused on their functional properties after such sequential maturation. Here, we studied human DC phenotypes and functions according to this sequential exposure to maturation stimuli. As first signals, we used TNF-α/polyI:C mimicking inflammatory and pathogen stimuli and, as second signals, we compared activated CD4+ T helper cells to a combination of CD40-L/ IFN-γ. Our results show that a sequential activation with activated CD4+ T cells dramatically increased the maturation of DCs in terms of their phenotype and cytokine secretion compared to DCs activated with maturation stimuli delivered simultaneously. Furthermore, this sequential maturation led to the induction of CTL with a long-term effector and central memory phenotypes. Thus, sequential delivery of maturation stimuli, which includes CD4+ T cells, should be considered in the future to improve the induction of long-term CTL memory in DC-based immunotherapy.

  11. Human dendritic cells sequentially matured with CD4(+) T cells as a secondary signal favor CTL and long-term T memory cell responses.

    Science.gov (United States)

    Simon, Thomas; Tanguy-Royer, Séverine; Royer, Pierre-Joseph; Boisgerault, Nicolas; Frikeche, Jihane; Fonteneau, Jean-François; Grégoire, Marc

    2012-01-01

    Dendritic cells (DCs) are professional antigen-presenting cells involved in the control and initiation of immune responses. In vivo, DCs exposed at the periphery to maturation stimuli migrate to lymph nodes, where they receive secondary signals from CD4+ T helper cells. These DCs become able to initiate CD8+ cytotoxic T lymphocyte (CTL) responses. However, in vitro investigations concerning human monocyte-derived DCs have never focused on their functional properties after such sequential maturation. Here, we studied human DC phenotypes and functions according to this sequential exposure to maturation stimuli. As first signals, we used TNF-α/polyI:C mimicking inflammatory and pathogen stimuli and, as second signals, we compared activated CD4+ T helper cells to a combination of CD40-L/ IFN-γ. Our results show that a sequential activation with activated CD4+ T cells dramatically increased the maturation of DCs in terms of their phenotype and cytokine secretion compared to DCs activated with maturation stimuli delivered simultaneously. Furthermore, this sequential maturation led to the induction of CTL with a long-term effector and central memory phenotypes. Thus, sequential delivery of maturation stimuli, which includes CD4+ T cells, should be considered in the future to improve the induction of long-term CTL memory in DC-based immunotherapy.

  12. Introduction of a point mutation into an HLA class I single-chain trimer induces enhancement of CTL priming and antitumor immunity

    Directory of Open Access Journals (Sweden)

    Masanori Matsui

    2014-01-01

    Full Text Available We previously discovered one particular HLA-A*02:01 mutant that enhanced peptide-specific cytotoxic T lymphocyte (CTL recognition in vitro compared to wild-type HLA-A*02:01. This mutant contains a single amino acid substitution from histidine to leucine at position 74 (H74L that is located in the peptide-binding groove. To investigate the effect of the H74L mutation on the in vivo CTL priming, we took advantage of the technology of the HLA class I single-chain trimer (SCT in which three components involving a peptide, β2 microglobulin and the HLA class I heavy chain are joined together via flexible linkers. We generated recombinant adenovirus expressing SCT comprised influenza A matrix protein (FMP-derived peptide, β2 microglobulin and the H74L heavy chain. HLA-A*02:01 transgenic mice were immunized with the adenovirus, and the induction of peptide-specific CTLs and antitumor immunity was investigated. It was clearly shown that the H74L mutation enabled the HLA-A*02:01 SCT molecule to dramatically enhance both in vivo priming of FMP-specific CTLs and protection against a lethal challenge of tumor cells expressing FMP. These data present the first evidence that a simple point mutation in the HLA class I heavy chain of SCT is beneficial for improving CTL-based immunotherapy and prophylaxis to control tumors.

  13. Response of ELA-A1 horses immunized with lipopeptide containing an equine infectious anemia virus ELA-A1-restricted CTL epitope to virus challenge.

    Science.gov (United States)

    Ridgely, Sherritta L; Zhang, Baoshan; McGuire, Travis C

    2003-01-17

    Lipopeptide containing an ELA-A1-restricted cytotoxic T lymphocyte (CTL) epitope from the envelope surface unit (SU) protein of the EIAV(WSU5) strain was used to immunize three horses having the ELA-A1 haplotype. Peptide-specific ELA-A1-restricted CTL were induced in all three horses, although these were present transiently in PBMC. These horses were further immunized with lipopeptide containing the corresponding CTL epitope from the EIAV(PV) strain. Then, the three immunized horses and three non-immunized horses were challenged by intravenous inoculation with 300 TCID(50) EIAV(PV). All horses developed cell free viremia, fever and thrombocytopenia. However, there was a statistically lower fever and thrombocytopenia severity score in the immunized group. Shorter duration of plasma viral load in two of the three immunized horses likely explains the less severe clinical disease in this group. Results indicate that lipopeptide immunization had a protective effect against development of clinical disease following virus challenge.

  14. The second advanced lead lithium blanket concept using ODS steel as structural material and SiCf/SiC flow channel inserts as electrical and thermal insulators (Task PPA 2.5). Final report

    International Nuclear Information System (INIS)

    Norajitra, P.; Buehler, L.; Fischer, U.

    1999-12-01

    Preparatory work on the advanced dual coolant (A-DCL) blanket concept using SiC f /SiC flow channel inserts as electrical and thermal insulators has been carried out at the Forschungszentrum Karlsruhe in co-operation with CEA as a conceptual design proposal to the EU fusion power plant study planned to be launched in 2000 within the framework of the EU fusion programme with the main objective of specifying the characteristics of an attractive and viable commercial D-T fusion power plant. The basic principles and design characteristics of this A-DCL blanket concept are presented and its potential with regard to performance (neutron wall load, lifetime, availability) is discussed in this report. The results of this study show that the A-DCL blanket concept has a high potential for further development due to its high thermal efficiency and its simple concept solution. (orig.) [de

  15. Practicality of Elementary Statistics Module Based on CTL Completed by Instructions on Using Software R

    Science.gov (United States)

    Delyana, H.; Rismen, S.; Handayani, S.

    2018-04-01

    This research is a development research using 4-D design model (define, design, develop, and disseminate). The results of the define stage are analyzed for the needs of the following; Syllabus analysis, textbook analysis, student characteristics analysis and literature analysis. The results of textbook analysis obtained the description that of the two textbooks that must be owned by students also still difficulty in understanding it, the form of presentation also has not facilitated students to be independent in learning to find the concept, textbooks are also not equipped with data processing referrals by using software R. The developed module is considered valid by the experts. Further field trials are conducted to determine the practicality and effectiveness. The trial was conducted to the students of Mathematics Education Study Program of STKIP PGRI which was taken randomly which has not taken Basic Statistics Course that is as many as 4 people. Practical aspects of attention are easy, time efficient, easy to interpret, and equivalence. The practical value in each aspect is 3.7; 3.79, 3.7 and 3.78. Based on the results of the test students considered that the module has been very practical use in learning. This means that the module developed can be used by students in Elementary Statistics learning.

  16. PERBANDINGAN HASIL BELAJAR IPA SEKOLAH DASAR MELALUI PENGGUNAAN PENDEKATAN GUIDED DISCOVERY DAN PENDEKATAN CTL (CONTEXTUAL TEACHING AND LEARNING

    Directory of Open Access Journals (Sweden)

    Fiky Ernawati

    2016-09-01

    Full Text Available Abstrak. Penelitian ini bertujuan untuk mengetahui perbandingan hasil belajar pada mata pelajaran IPA setelah menggunakan pendekatan pembelajaran Guided Discovery dengan pendekatan pembelajaran CTL (Contextual Teaching and Learning pada siswa  kelas  IV SD Negeri  3  Kramatwatu.  Metode  penelitian yang digunakan adalah metode kuasi ekpserimen, sedangkan desain penelitian yang digunakan adalah non equivalent control group design. Ada dua kelas dalam penelitian ini, yaitu kelompok eksperimen dan kelompok kontrol. Kelompok eksperimen yaitu siswa  kelas  IV-A  terdiri  dari  35  siswa  yang  diberikan  perlakuan  dengan pendekatan pembelajaran Guided Discovery dan kelas kontrol yaitu siswa kelas IV-B terdiri dari 33 siswa yang diberikan perlakuan pendekatan pembelajaran CTL (Contextual Teaching and Learning. Ada pun teknik pengumpulan data yang dilakukan meliputi tes hasil belajar berupa posttest serta nontes berupa dokumentasi.   Berdasarkan   hasil   penelitian   menunjukkan   bahwa   terdapat perbedaan hasil belajar siswa kelas eksperimen dan siswa kelas kontrol. Hasil belajar IPA siswa kelas eksperimen lebih tinggi daripada hasil belajar IPA siswa kelas kontrol. Rata-rata hasil belajar IPA kelas eksperimen yaitu 76,07 dan kelas kontrol memperoleh rata-rata 69,34. Kata Kunci : Hasil Belajar IPA, Guided Discovery, Contextual Teaching and Learning   Abstract. This research attempts to know the comparison of the results learning on subject’s science  class  after  using  learning  guided  discovery  approach  with  contextual teaching  and  learning  approach  to  their  student’s  grade  4  of  public  school Kramatwatu  7.  Research methodology used  is the method quasi  experiments, while design research used is non equivalent control group design.There are two classes  in  this  research,  namely  experiment  group  and  control  groups.  The experiment group that is a

  17. Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.

    Directory of Open Access Journals (Sweden)

    Morgane Rolland

    Full Text Available BACKGROUND: While human immunodeficiency virus type 1 (HIV-1-specific cytotoxic T lymphocytes preferentially target specific regions of the viral proteome, HIV-1 features that contribute to immune recognition are not well understood. One hypothesis is that similarities between HIV and human proteins influence the host immune response, i.e., resemblance between viral and host peptides could preclude reactivity against certain HIV epitopes. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the extent of similarity between HIV-1 and the human proteome. Proteins from the HIV-1 B consensus sequence from 2001 were dissected into overlapping k-mers, which were then probed against a non-redundant database of the human proteome in order to identify segments of high similarity. We tested the relationship between HIV-1 similarity to host encoded peptides and immune recognition in HIV-infected individuals, and found that HIV immunogenicity could be partially modulated by the sequence similarity to the host proteome. ELISpot responses to peptides spanning the entire viral proteome evaluated in 314 individuals showed a trend indicating an inverse relationship between the similarity to the host proteome and the frequency of recognition. In addition, analysis of responses by a group of 30 HIV-infected individuals against 944 overlapping peptides representing a broad range of individual HIV-1B Nef variants, affirmed that the degree of similarity to the host was significantly lower for peptides with reactive epitopes than for those that were not recognized. CONCLUSIONS/SIGNIFICANCE: Our results suggest that antigenic motifs that are scarcely represented in human proteins might represent more immunogenic CTL targets not selected against in the host. This observation could provide guidance in the design of more effective HIV immunogens, as sequences devoid of host-like features might afford superior immune reactivity.

  18. Integration of Advanced Concepts and Vehicles Into the Next Generation Air Transportation System. Volume 1; Introduction, Key Messages, and Vehicle Attributes

    Science.gov (United States)

    Zellweger, Andres; Resnick, Herbert; Stevens, Edward; Arkind, Kenneth; Cotton William B.

    2010-01-01

    Raytheon, in partnership with NASA, is leading the way in ensuring that the future air transportation continues to be a key driver of economic growth and stability and that this system provides an environmentally friendly, safe, and effective means of moving people and goods. A Raytheon-led team of industry and academic experts, under NASA contract NNA08BA47C, looked at the potential issues and impact of introducing four new classes of advanced aircraft into the next generation air transportation system -- known as NextGen. The study will help determine where NASA should further invest in research to support the safe introduction of these new air vehicles. Small uncrewed or unmanned aerial systems (SUAS), super heavy transports (SHT) including hybrid wing body versions (HWB), very light jets (VLJ), and supersonic business jets (SSBJ) are the four classes of aircraft that we studied. Understanding each vehicle's business purpose and strategy is critical to assessing the feasibility of new aircraft operations and their impact on NextGen's architecture. The Raytheon team used scenarios created by aviation experts that depict vehicles in year 2025 operations along with scripts or use cases to understand the issues presented by these new types of vehicles. The information was then mapped into the Joint Planning and Development Office's (JPDO s) Enterprise Architecture to show how the vehicles will fit into NextGen's Concept of Operations. The team also identified significant changes to the JPDO's Integrated Work Plan (IWP) to optimize the NextGen vision for these vehicles. Using a proven enterprise architecture approach and the JPDO s Joint Planning Environment (JPE) web site helped make the leap from architecture to planning efficient, manageable and achievable. Very Light Jets flying into busy hub airports -- Supersonic Business Jets needing to climb and descend rapidly to achieve the necessary altitude Super-heavy cargo planes requiring the shortest common flight

  19. Development of a Luminex Bead Based Assay for Diagnosis of Toxocariasis Using Recombinant Antigens Tc-CTL-1 and Tc-TES-26.

    Directory of Open Access Journals (Sweden)

    John P Anderson

    Full Text Available The clinical spectrum of human disease caused by the roundworms Toxocara canis and Toxocara cati ranges from visceral and ocular larva migrans to covert toxocariasis. The parasite is not typically recovered in affected tissues, so detection of parasite-specific antibodies is usually necessary for establishing a diagnosis. The most reliable immunodiagnostic methods use the Toxocara excretory-secretory antigens (TES-Ag in ELISA formats to detect Toxocara-specific antibodies. To eliminate the need for native parasite materials, we identified and purified immunodiagnostic antigens using 2D gel electrophoresis followed by electrospray ionization mass spectrometry. Three predominant immunoreactive proteins were found in the TES; all three had been previously described in the literature: Tc-CTL-1, Tc-TES-26, and Tc-MUC-3. We generated Escherichia coli expressed recombinant proteins for evaluation in Luminex based immunoassays. We were unable to produce a functional assay with the Tc-MUC-3 recombinant protein. Tc-CTL-1 and Tc-TES-26 were successfully coupled and tested using defined serum batteries. The use of both proteins together generated better results than if the proteins were used individually. The sensitivity and specificity of the assay for detecting visceral larval migrans using Tc-CTL-1 plus Tc-TES-26 was 99% and 94%, respectively; the sensitivity for detecting ocular larval migrans was 64%. The combined performance of the new assay was superior to the currently available EIA and could potentially be employed to replace current assays that rely on native TES-Ag.

  20. AdvancED Flex 4

    CERN Document Server

    Tiwari, Shashank; Schulze, Charlie

    2010-01-01

    AdvancED Flex 4 makes advanced Flex 4 concepts and techniques easy. Ajax, RIA, Web 2.0, mashups, mobile applications, the most sophisticated web tools, and the coolest interactive web applications are all covered with practical, visually oriented recipes. * Completely updated for the new tools in Flex 4* Demonstrates how to use Flex 4 to create robust and scalable enterprise-grade Rich Internet Applications.* Teaches you to build high-performance web applications with interactivity that really engages your users.* What you'll learn Practiced beginners and intermediate users of Flex, especially

  1. Specialities of the differentiation conditions for the memory cells - either initial or enriched secondary cytotoxic T lymphocyte precursors (pCTL-2) specific to the MHC molecule class 1

    International Nuclear Information System (INIS)

    Brondz, B.D.; Osipova, T.V.; Aptikaeva, G.F.; Kronin, V.V.

    1989-01-01

    The in vivo induced pCTL-2 with phenotype L3T4 - Lyt2 + , specific to the H-2K b molecule, turn into effector CTLs during 4 days in the mixed lymphocyte culture (with heat-treated donor stimulators) much more efficiency when donor and recipient are different from one another not only in MHC class 1 (anti-BIO, MBR BIO.AKM) but in 1+2 (K b +1 b ) anti-C57BL/6 BIAD2(R1O1). The initial pCTL-2 differentiation in enhanced as a result of synergistic effect between the K b alloantigen and rIL2. The anti-K b pCTL-2, being separated from helper T cells by means of absorption onto the macrophage donor monolayer and elution from it, give rise to pronounced differentiation in simplified conditions, irrespective of the stimulator presence and without external rIL2. It is supposed that these phenomena are roused to secrection of the CTL differentiation factor by the eluted pCTL-2 themselves, and besides, rIL2 may promote for secretion of this factor additionally

  2. Development project HTR-electricity-generating plant, concept design of an advanced high-temperature reactor steam cycle plant with spherical fuel elements (HTR-K)

    International Nuclear Information System (INIS)

    1978-07-01

    The report gives a survey of the principal work which was necessary to define the design criteria, to determine the main design data, and to design the principal reactor components for a large steam cycle plant. It is the objective of the development project to establish a concept design of an edvanced steam cycle plant with a pebble bed reactor to permit a comparison with the direct-cycle-plant and to reach a decision on the concept of a future high-temperature nuclear power plant. It is tried to establish a largerly uniform basic concept of the nuclear heat-generating systems for the electricity-generating and the process heat plant. (orig.) [de

  3. Th cells promote CTL survival and memory via acquired pMHC-I and endogenous IL-2 and CD40L signaling and by modulating apoptosis-controlling pathways.

    Directory of Open Access Journals (Sweden)

    Channakeshava Sokke Umeshappa

    Full Text Available Involvement of CD4(+ helper T (Th cells is crucial for CD8(+ cytotoxic T lymphocyte (CTL-mediated immunity. However, CD4(+ Th's signals that govern CTL survival and functional memory are still not completely understood. In this study, we assessed the role of CD4(+ Th cells with acquired antigen-presenting machineries in determining CTL fates. We utilized an adoptive co-transfer into CD4(+ T cell-sufficient or -deficient mice of OTI CTLs and OTII Th cells or Th cells with various gene deficiencies pre-stimulated in vitro by ovalbumin (OVA-pulsed dendritic cell (DCova. CTL survival was kinetically assessed in these mice using FITC-anti-CD8 and PE-H-2K(b/OVA257-264 tetramer staining by flow cytometry. We show that by acting via endogenous CD40L and IL-2, and acquired peptide-MHC-I (pMHC-I complex signaling, CD4(+ Th cells enhance survival of transferred effector CTLs and their differentiation into the functional memory CTLs capable of protecting against highly-metastasizing tumor challenge. Moreover, RT-PCR, flow cytometry and Western blot analysis demonstrate that increased survival of CD4(+ Th cell-helped CTLs is matched with enhanced Akt1/NF-κB activation, down-regulation of TRAIL, and altered expression profiles with up-regulation of prosurvival (Bcl-2 and down-regulation of proapoptotic (Bcl-10, Casp-3, Casp-4, Casp-7 molecules. Taken together, our results reveal a previously unexplored mechanistic role for CD4(+ Th cells in programming CTL survival and memory recall responses. This knowledge could also aid in the development of efficient adoptive CTL cancer therapy.

  4. Th cells promote CTL survival and memory via acquired pMHC-I and endogenous IL-2 and CD40L signaling and by modulating apoptosis-controlling pathways.

    Science.gov (United States)

    Umeshappa, Channakeshava Sokke; Xie, Yufeng; Xu, Shulin; Nanjundappa, Roopa Hebbandi; Freywald, Andrew; Deng, Yulin; Ma, Hong; Xiang, Jim

    2013-01-01

    Involvement of CD4(+) helper T (Th) cells is crucial for CD8(+) cytotoxic T lymphocyte (CTL)-mediated immunity. However, CD4(+) Th's signals that govern CTL survival and functional memory are still not completely understood. In this study, we assessed the role of CD4(+) Th cells with acquired antigen-presenting machineries in determining CTL fates. We utilized an adoptive co-transfer into CD4(+) T cell-sufficient or -deficient mice of OTI CTLs and OTII Th cells or Th cells with various gene deficiencies pre-stimulated in vitro by ovalbumin (OVA)-pulsed dendritic cell (DCova). CTL survival was kinetically assessed in these mice using FITC-anti-CD8 and PE-H-2K(b)/OVA257-264 tetramer staining by flow cytometry. We show that by acting via endogenous CD40L and IL-2, and acquired peptide-MHC-I (pMHC-I) complex signaling, CD4(+) Th cells enhance survival of transferred effector CTLs and their differentiation into the functional memory CTLs capable of protecting against highly-metastasizing tumor challenge. Moreover, RT-PCR, flow cytometry and Western blot analysis demonstrate that increased survival of CD4(+) Th cell-helped CTLs is matched with enhanced Akt1/NF-κB activation, down-regulation of TRAIL, and altered expression profiles with up-regulation of prosurvival (Bcl-2) and down-regulation of proapoptotic (Bcl-10, Casp-3, Casp-4, Casp-7) molecules. Taken together, our results reveal a previously unexplored mechanistic role for CD4(+) Th cells in programming CTL survival and memory recall responses. This knowledge could also aid in the development of efficient adoptive CTL cancer therapy.

  5. Framework Programmable Platform for the Advanced Software Development Workstation (FPP/ASDW). Demonstration framework document. Volume 1: Concepts and activity descriptions

    Science.gov (United States)

    Mayer, Richard J.; Blinn, Thomas M.; Dewitte, Paul S.; Crump, John W.; Ackley, Keith A.

    1992-01-01

    The Framework Programmable Software Development Platform (FPP) is a project aimed at effectively combining tool and data integration mechanisms with a model of the software development process to provide an intelligent integrated software development environment. Guided by the model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated. The Advanced Software Development Workstation (ASDW) program is conducting research into development of advanced technologies for Computer Aided Software Engineering (CASE).

  6. Advancement of the climate dual strategy. New concepts for a globally effective climate protection; Weiterentwicklung der baden-wuerttembergischen Klimadoppelstrategie. Neue Konzepte fuer einen global wirksamen Klimaschutz

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-10-15

    The Baden-Wuerttemberg Council on Sustainable Development (Stuttgart, Federal Republic of Germany) presents a climate expert report with new concepts for a globally effective climate protection. First of all, the development of the global emissions of carbon dioxide since 1990 is described. The development of the global emissions of carbon dioxide up to 2050 is forecasted. Four general criteria (effectiveness, efficiency, fairness and acceptance) for a comparative evaluation of climate protection concepts are introduced. A proposal for solution on the basis of a globally effective cap-and-trade system as well as an identical scenario as an alternative with respect to the implementation are described. This alternative scenario is based on a cap-and-trade system but it develops on the basis of national self-commitment in accordance with an incentive and sanctionative system. Both implementation proposals are compared. Recommendations of the national government Baden-Wuerttemberg are given.

  7. Advanced calculus

    CERN Document Server

    Nickerson, HK; Steenrod, NE

    2011-01-01

    ""This book is a radical departure from all previous concepts of advanced calculus,"" declared the Bulletin of the American Mathematics Society, ""and the nature of this departure merits serious study of the book by everyone interested in undergraduate education in mathematics."" Classroom-tested in a Princeton University honors course, it offers students a unified introduction to advanced calculus. Starting with an abstract treatment of vector spaces and linear transforms, the authors introduce a single basic derivative in an invariant form. All other derivatives - gradient, divergent, curl,

  8. Performance Evaluation of the Concept of Hybrid Heat Pipe as Passive In-core Cooling Systems for Advanced Nuclear Power Plant

    International Nuclear Information System (INIS)

    Jeong, Yeong Shin; Kim, Kyung Mo; Kim, In Guk; Bang, In Cheol

    2015-01-01

    As an arising issue for inherent safety of nuclear power plant, the concept of hybrid heat pipe as passive in-core cooling systems was introduced. Hybrid heat pipe has unique features that it is inserted in core directly to remove decay heat from nuclear fuel without any changes of structures of existing facilities of nuclear power plant, substituting conventional control rod. Hybrid heat pipe consists of metal cladding, working fluid, wick structure, and neutron absorber. Same with working principle of the heat pipe, heat is transported by phase change of working fluid inside metal cask. Figure 1 shows the systematic design of the hybrid heat pipe cooling system. In this study, the concept of a hybrid heat pipe was introduced as a Passive IN-core Cooling Systems (PINCs) and demonstrated for internal design features of heat pipe containing neutron absorber. Using a commercial CFD code, single hybrid heat pipe model was analyzed to evaluate thermal performance in designated operating condition. Also, 1-dimensional reactor transient analysis was done by calculating temperature change of the coolant inside reactor pressure vessel using MATLAB. As a passive decay heat removal device, hybrid heat pipe was suggested with a concept of combination of heat pipe and control rod. Hybrid heat pipe has distinct feature that it can be a unique solution to cool the reactor when depressurization process is impossible so that refueling water cannot be injected into RPV by conventional ECCS. It contains neutron absorber material inside heat pipe, so it can stop the reactor and at the same time, remove decay heat in core. For evaluating the concept of hybrid heat pipe, its thermal performance was analyzed using CFD and one-dimensional transient analysis. From single hybrid heat pipe simulation, the hybrid heat pipe can transport heat from the core inside to outside about 18.20 kW, and total thermal resistance of hybrid heat pipe is 0.015 .deg. C/W. Due to unique features of long heat

  9. Biologic Treatments for Sports Injuries II Think Tank-Current Concepts, Future Research, and Barriers to Advancement, Part 1: Biologics Overview, Ligament Injury, Tendinopathy.

    Science.gov (United States)

    LaPrade, Robert F; Geeslin, Andrew G; Murray, Iain R; Musahl, Volker; Zlotnicki, Jason P; Petrigliano, Frank; Mann, Barton J

    2016-12-01

    Biologic therapies, including stem cells, platelet-rich plasma, growth factors, and other biologically active adjuncts, have recently received increased attention in the basic science and clinical literature. At the 2015 AOSSM Biologics II Think Tank held in Colorado Springs, Colorado, a group of orthopaedic surgeons, basic scientists, veterinarians, and other investigators gathered to review the state of the science for biologics and barriers to implementation of biologics for the treatment of sports medicine injuries. This series of current concepts reviews reports the summary of the scientific presentations, roundtable discussions, and recommendations from this think tank. © 2016 The Author(s).

  10. Elastic/plastic analyses of advanced composites investigating the use of the compliant layer concept in reducing residual stresses resulting from processing

    Science.gov (United States)

    Arnold, Steven M.; Arya, Vinod K.; Melis, Matthew E.

    1990-01-01

    High residual stresses within intermetallic and metal matrix composite systems can develop upon cooling from the processing temperature to room temperature due to the coefficient of thermal expansion (CTE) mismatch between the fiber and matrix. As a result, within certain composite systems, radial, circumferential, and/or longitudinal cracks have been observed to form at the fiber-matrix interface. The compliant layer concept (insertion of a compensating interface material between the fiber and matrix) was proposed to reduce or eliminate the residual stress buildup during cooling and thus minimize cracking. The viability of the proposed compliant layer concept is investigated both elastically and elastoplastically. A detailed parametric study was conducted using a unit cell model consisting of three concentric cylinders to determine the required character (i.e., thickness and material properties) of the compliant layer as well as its applicability. The unknown compliant layer mechanical properties were expressed as ratios of the corresponding temperature dependent Ti-24Al-11Nb (a/o) matrix properties. The fiber properties taken were those corresponding to SCS-6 (SiC). Results indicate that the compliant layer can be used to reduce, if not eliminate, radial and circumferential residual stresses within the fiber and matrix and therefore also reduce or eliminate the radial cracking. However, with this decrease in in-plane stresses, one obtains an increase in longitudinal stress, thus potentially initiating longitudinal cracking. Guidelines are given for the selection of a specific compliant material, given a perfectly bonded system.

  11. THE DEVELOPMENT OF ELECTRONIC TEACHING MATERIALS BY FLIPBOOK ASSISTANCE BASED PROBLEM SOLVING SKILL WITH CTL APPROACH ON LEARNING MATHEMATICS CLASS V

    Directory of Open Access Journals (Sweden)

    RUSNILAWATI Eva Gustiana RUSNILAWATI

    2018-01-01

    Full Text Available The purpose of this research is to produce Flipbook-based Electronic Teaching Materials (BAE based on problem solving skills with CTL Approach on Vocational School Class V learning valid, practical, and effective. This type of research is development research (Development Research. This research developed Flipbook-assisted Electronic Teaching Materials (BAE on the mathematics learning of Class V Primary School by using the 4-D development model developed by Thiagarajan, Semmel, and Semmel. The validation results show that the developed Teaching Materials are worthy of use with a good minimum category. The results of the experiments show that Electronic Materials developed are practical and effective. Completed learning in the classical has reached the minimum criteria of 75% that is for problem-solving test reached 86%. Based on a questionnaire of attitudes toward mathematics, 88% of students showed an increase in attitude scores on mathematics, and 85% of students showed attitudes toward mathematics with a good minimum category.

  12. Therapy of established B16-F10 melanoma tumors by a single vaccination of CTL/T helper peptides in VacciMax®

    Directory of Open Access Journals (Sweden)

    Korets-Smith Ella

    2007-04-01

    Full Text Available Abstract Background Melanoma tumors are known to express antigens that usually induce weak immune responses of short duration. Expression of both tumor-associated antigens p53 and TRP2 by melanoma cells raises the possibility of simultaneously targeting more than one antigen in a therapeutic vaccine. In this report, we show that VacciMax® (VM, a novel liposome-based vaccine delivery platform, can increase the immunogenicity of melanoma associated antigens, resulting in tumor elimination. Methods C57BL/6 mice bearing B16-F10 melanoma tumors were vaccinated subcutaneously 6 days post tumor implantation with a mixture of synthetic peptides (modified p53: 232–240, TRP-2: 181–188 and PADRE and CpG. Tumor growth was monitored and antigen-specific splenocyte responses were assayed by ELISPOT. Results Vaccine formulated in VM increased the number of both TRP2- and p53-specific IFN-γ producing splenocytes following a single vaccination. Vaccine formulated without VM resulted only in enhanced IFN-γ producing splenocytes to one CTL epitopes (TRP2:180–188, suggesting that VM overcomes antigen dominance and enhances immunogenicity of multiple epitopes. Vaccination of mice bearing 6-day old B16-F10 tumors with both TRP2 and p53-peptides formulated in VM successfully eradicated tumors in all mice. A control vaccine which contained all ingredients except liposomes resulted in eradication of tumors in no more than 20% of mice. Conclusion A single administration of VM is capable of inducing an effective CTL response to multiple tumor-associated antigens. The responses generated were able to reject 6-day old B16-F10 tumors.

  13. Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway

    Science.gov (United States)

    Shime, Hiroaki; Matsumoto, Misako; Seya, Tsukasa

    2017-01-01

    PolyI:C, a synthetic double-stranded RNA analog, acts as an immune-enhancing adjuvant that regresses tumors in cytotoxic T lymphocyte (CTL)-dependent and CTL-independent manner, the latter of which remains largely unknown. Tumors contain CD11b+Ly6G+ cells, known as granulocytic myeloid-derived suppressor cells (G-MDSCs) or tumor-associated neutrophils (TANs) that play a critical role in tumor progression and development. Here, we demonstrate that CD11b+Ly6G+ cells respond to polyI:C and exhibit tumoricidal activity in an EL4 tumor implant model. PolyI:C-induced inhibition of tumor growth was attributed to caspase-8/3 cascade activation in tumor cells that occurred independently of CD8α+/CD103+ dendritic cells (DCs) and CTLs. CD11b+Ly6G+ cells was essential for the antitumor effect because depletion of CD11b+Ly6G+ cells totally abrogated tumor regression and caspase activation after polyI:C treatment. CD11b+Ly6G+ cells that had been activated with polyI:C showed cytotoxicity and inhibited tumor growth through the production of reactive oxygen species (ROS)/reactive nitrogen species (RNS). These responses were abolished in either Toll/interleukin-1 receptor domain-containing adaptor molecule-1 (TICAM-1)−/− or interferon (IFN)-αβ receptor 1 (IFNAR1)−/− mice. Thus, our results suggest that polyI:C activates the TLR3/TICAM-1 and IFNAR signaling pathways in CD11b+Ly6G+ cells in tumors, thereby eliciting their antitumor activity, independent of those in CD8α+/CD103+ DCs that prime CTLs. PMID:27834952

  14. Design concepts for the Cherenkov Telescope Array CTA: an advanced facility for ground-based high-energy gamma-ray astronomy

    International Nuclear Information System (INIS)

    Allekotte, I.; Arnaldi, H.; Asorey, H.; Gomez Berisso, M.; Sofo Haro, M.; Cillis, A.; Rovero, A.C.; Supanitsky, A.D.; Actis, M.; Antico, F.; Bottani, A.; Ochoa, I.; Ringegni, P.; Vallejo, G.; De La Vega, G.; Etchegoyen, A.; Videla, M.; Gonzalez, F.; Pallota, J.; Quel, E.; Ristori, P.; Romero, G.E.; Suarez, A.; Papyan, G.; Pogosyan, L.; Sahakian, V.; Bissaldi, E.; Egberts, K.; Reimer, A.; Reimer, O.; Shellard, R.C.; Santos, E.M.; De Gouveia Dal Pino, E.M.; Kowal, G.; De Souza, V.; Todero Peixoto, C.J.; Maneva, G.; Temnikov, P.; Vankov, H.; Golev, V.; Ovcharov, E.; Bonev, T.; Dimitrov, D.; Hrupec, D.; Nedbal, D.; Rob, L.; Sillanpaa, A.; Takalo, L.; Beckmann, V.; Benallou, M.; Boutonnet, C.; Corlier, M.; Courty, B.; Djannati-Atai, A.; Dufour, C.; Gabici, S.; Guglielmi, L.; Olivetto, C.; Pita, S.; Punch, M.; Selmane, S.; Terrier, R.; Yoffo, B.; Brun, P.; Carton, P.H.; Cazaux, S.; Corpace, O.; Delagnes, E.; Disset, G.; Durand, D.; Glicenstein, J.F.; Guilloux, F.; Kosack, K.; Medina, C.; Micolon, P.; Mirabel, F.; Moulin, E.; Peyaud, B.; Reymond, J.M.; Veyssiere, C.

    2011-01-01

    Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA. (authors)

  15. From the rhetoric to the real: A critical review of how the concepts of recovery and social inclusion may inform mental health nurse advanced level curricula - The eMenthe project.

    Science.gov (United States)

    Stickley, Theodore; Higgins, Agnes; Meade, Oonagh; Sitvast, Jan; Doyle, Louise; Ellilä, Heikki; Jormfeldt, Henrika; Keogh, Brian; Lahti, Mari; Skärsäter, Ingela; Vuokila-Oikkonen, Paivi; Kilkku, Nina

    2016-02-01

    This critical review addresses the question of how the concepts of recovery and social inclusion may inform mental health nurse education curricula at Master's level in order to bring about significant and positive change to practice. This is a literature-based critical review incorporating a rapid review. It has been said that if done well, this approach can be highly relevant to health care studies and social interventions, and has substantial claims to be as rigorous and enlightening as other, more conventional approaches to literature (Rolfe, 2008). In this review, we have accessed contemporary literature directly related to the concepts of recovery and social inclusion in mental health. We have firstly surveyed the international literature directly related to the concepts of recovery and social inclusion in mental health and used the concept of emotional intelligence to help consider educational outcomes in terms of the required knowledge, skills and attitudes needed to promote these values-based approaches in practice. A number of themes have been identified that lend themselves to educational application. International frameworks exist that provide some basis for the developments of recovery and social inclusion approaches in mental health practice, however the review identifies specific areas for future development. This is the first article that attempts to scope the knowledge, attitudes and skills required to deliver education for Master's level mental health nurses based upon the principles of recovery and social inclusion. Emotional intelligence theory may help to identify desired outcomes especially in terms of attitudinal development to promote the philosophy of recovery and social inclusive approaches in advanced practice. Whilst recovery is becoming enshrined in policy, there is a need in higher education to ensure that mental health nurse leaders are able to discern the difference between the rhetoric and the reality. Copyright © 2015 Elsevier Ltd

  16. Platelet-rich plasma and its derivatives as promising bioactive materials for regenerative medicine: basic principles and concepts underlying recent advances.

    Science.gov (United States)

    Kawase, Tomoyuki

    2015-05-01

    Over the past decade, platelet-rich plasma (PRP), a platelet-concentrated plasma fraction, has been widely investigated and applied to regenerative medicine. The clinical utility of PRP is supported by evidence that PRP contains high concentrations of platelet-related growth factors and normal concentrations of plasma-derived fibrinogen, both of which contribute synergistically to the regenerative process. Additionally, its superior cost-efficacy versus conventional therapies is attractive to many clinicians. However, current disadvantages of PRP include a relatively complicated preparation procedure and variable operator-dependent efficacy. An additional disadvantage is the use of bovine thrombin, an animal-derived biological, as a coagulant. Many of these disadvantages are overcome by recent advances in preparation procedures and devices; for example, Joseph Choukroun simplified the platelet-rich fibrin preparation procedure and improved handling efficiency without the aid of animal-derived factors. With advancements in cell processing technology, there has been a general shift in cell therapy from autologous to allogeneic treatment; however, autologous PRP therapy will not easily be replaced by allogeneic treatment in the near future. Therefore, to provide more predictable regenerative therapy outcomes using autologous PRP, further investigations should address developing a standardized procedure for PRP preparation to augment its efficacy and potency, independent of donor variability. We would then propose that operators and clinicians prepare PRP according to the standardized protocol and to carefully evaluate the clinical scenario (i.e., recipient factors comprising skeletal defects) to determine which factor(s) should be added to PRP preparations. This careful approach will lead to improved clinical outcomes for patients.

  17. Concepts of formal concept analysis

    Science.gov (United States)

    Žáček, Martin; Homola, Dan; Miarka, Rostislav

    2017-07-01

    The aim of this article is apply of Formal Concept Analysis on concept of world. Formal concept analysis (FCA) as a methodology of data analysis, information management and knowledge representation has potential to be applied to a verity of linguistic problems. FCA is mathematical theory for concepts and concept hierarchies that reflects an understanding of concept. Formal concept analysis explicitly formalizes extension and intension of a concept, their mutual relationships. A distinguishing feature of FCA is an inherent integration of three components of conceptual processing of data and knowledge, namely, the discovery and reasoning with concepts in data, discovery and reasoning with dependencies in data, and visualization of data, concepts, and dependencies with folding/unfolding capabilities.

  18. Recent advances in the designing and the equipment of high activity laboratories; Progres recents dans la conception et l'equipement des laboratoires de haute activite

    Energy Technology Data Exchange (ETDEWEB)

    Bazire, R; Duhamel, F [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The authors described the general principles governing the design of a laboratory for experimenting and handling radioactive substances. The difficulties encountered are of two types: 1) those due to the dangers of external irradiation; 2) those due to the dangers of internal contamination. As an example, the authors describe the French achievements in this field and in particular: - the high-activity laboratories at Saclay; - the laboratory for the examination of irradiated fuels at Saclay; - the 'hot' laboratory of the CEN-Grenoble; - the alpha, beta and gamma laboratories of the CEN-Fontenay-aux-Roses. Finally, the report describes the protective materials used for these installations. (author) [French] Les auteurs exposent quels sont les principes generaux qui president a la conception d'un laboratoire a des travaux et des manipulations sur des substances radioactives. Les difficultes a surmonter sont de deux ordres: 1) celles qui proviennent du danger d'irradiation externe; 2) celles qui proviennent du danger de contamination interne. A titre d'exemple, les auteurs decrivent les realisations francaises dans ce domaine et en particulier: - le laboratoire de haute activite de Saclay, - le laboratoire d'examen des combustibles irradies de Saclay, - le laboratoire chaud du CEN-Grenoble, - les laboratoires alpha, beta, gamma du CEN-Fontenay-aux-Roses. Enfin, le rapport decrit les materiaux de protection mis en oeuvre pour ces realisations. (auteur)

  19. Palliative radiotherapy. Ranking within an interdisciplinary treatment concept in case of advanced tumor disease; Palliative Strahlentherapie. Rolle im interdisziplinaeren Behandlungskonzept bei fortgeschrittenem Tumorleiden

    Energy Technology Data Exchange (ETDEWEB)

    Seegenschmiedt, M.H. [Krupp Krankenanstalten Gemeinnuetzige GmbH, Essen (Germany). Klinik fuer Strahlentherapie und Nuklearmedizin

    1998-10-23

    Many tumor-induced symptoms can be alleviated by suitable irradiation in a direct, effective and sparing manner. The clinical response amounts to 80% and is independent of tumor histology. Careful diagnosis and accurate localisation of the causes of symptoms as well as exact therapy planning and execution are required. Based on individual dose planning harmonising single dosis and total dosis, pin-pointed definition of target areas, and application of modern planning and irradiation techniques, palliative radiotherapy is able to achieve long-term improvement with neglectible side-effects, sometimes within only a few days or weeks. It is a valuable part of a consistant therapy concept that is tailored to the individual needs of a patient, by cooperative action of experts from a variety of medical disciplines, intended to optimize the qulity of life of patients, and sometimes may exclude conventional radiotherapy. (orig./CB) [Deutsch] Viele tumorbedingten Symptome koennen mit Strahlentherapie kausal wirksam, effektiv und schonend behandelt werden. Das klinische Ansprechen betraegt 80% und ist unabhaengig von der Histologie des Tumors. Eine sorgfaeltige Indikationsstellung und genaue Lokalisation der Symptomursache sowie exakte Planung und Durchfuehrung der Strahlentherapie sind Bedingung. Mit einer individuellen Anpassung der Einzel- und Gesamtdosis, des Zielvolumens und dem Einsatz moderner Planungs- und Bestrahlungstechniken gelingt es, oft innerhalb weniger Tage bis Wochen eine langanhaltende Symptombesserung ohne wesentliche Nebenwirkungen zu erzielen. Die palliative Strahlentherapie ist dabei Teil eines Gesamtbehandlungskonzeptes, das interdisziplinaer abgestimmt ist und eine optimale Lebensqualitaet fuer den Tumorpatienten anstrebt, manchmal auch unter Verzicht auf eine Therapie. (orig.)

  20. A review of recent advances in the role of leak-before-break concept in assessments of flaws detected in CANDU pressure tubes

    International Nuclear Information System (INIS)

    Crespi, J.C.

    1994-01-01

    If a crack develops in a pressure tube, the leak is detected by monitoring the moisture in the gas annulus and the reactor shutdown before it becomes unstable. Because the delayed hydride cracking has been associated to date with all pressure tube failures at a rolled joints, the delayed hydride cracking is considered to be the dominant mecanism by which the flaws can grow to a size which exceeds the critical crack length. For the delayed hydride cracking failure mode leak-before-break is used as defense in depth against unstable rupture. The methodology depends on showing than the time available to detect a delayed hydride crack is much greater that the time required to detect it in the gas annulus. The time available is estimated from measurements of: (a) axial delayed hydride crack growth rates, (b) crack lengths at penetrations of the tube wall when leakage first occurs and (c) critical crack lengths at instability when a crack is growing by the delayed hydride cracking mechanism. A review of recent advances in the experimental data used in leak-before-break assessment are presented and discussed. (author). 17 refs, 6 figs, 2 tabs

  1. ASU and CO{sub 2} turbomachinery train technology for today's IGCC, CTL, and GTL applications

    Energy Technology Data Exchange (ETDEWEB)

    Scholtysik, M.; Keller, M.; Lauber, U. [MAN TURBO, Zurich (Switzerland)

    2007-07-01

    After outlining MAN TURBO's product range, the machine concept and train arrangement of the ASU trains are presented. A more detailed description of each type of compressor and driver follows, including their application and operating experience. The compression of CO{sub 2} with gear type compressors is then described. Application at Dakota Gasification Co's SNG plant is described where CO{sub 2} is sent to the Weyburn Oil Fields for Enhanced Oil Recovery. 31 figs.

  2. Advanced Electron Linacs

    Energy Technology Data Exchange (ETDEWEB)

    Siemann, R.

    2005-02-14

    The research into advanced acceleration concepts for electron linear accelerators being pursued at SLAC is reviewed. This research includes experiments in laser acceleration, plasma wakefield acceleration, and mmwavelength RF driven accelerators.

  3. Advanced Propulsion Study

    National Research Council Canada - National Science Library

    Davis, Eric

    2004-01-01

    ... that show promise of leading to a major advance in Earth-to-orbit (ETO) propulsion. The study also reviewed and evaluated a select number of credible far-term breakthrough propulsion physics concepts pertaining...

  4. Advancing the citizen scientist's contributions to documenting and understanding natural hazards: a proof of concept for linking crowdsourced and remotely sensed data on landslide hazards in El Salvador

    Science.gov (United States)

    Anderson, E. R.; Griffin, R.; Markert, K. N.

    2017-12-01

    Scientists, practitioners, policymakers, and citizen groups, share a role in ensuring "that all sectors have access to, understand and can use scientific information for better informed decision-making" (Sendai Framework 2015-2030). When it comes to understanding hazards and exposure, inventories on disaster events are often limited. Thus, there are many opportunities for citizen scientists to engage in improving the collective understanding—and ultimately reduction—of disaster risk. Landslides are very difficult to forecast on spatial and temporal scales meaningful for early warning and evacuation. Heuristic hazard mapping methods are very common in regional hazard zonation and rely on expert knowledge of previous events and local conditions, but they often lack a temporal component. As new data analysis packages are becoming more open and accessible, probabilistic approaches that consider high resolution spatial and temporal dimensions are becoming more common, but this is only possible when rich inventories of landslide events exist. The work presented offers a proof of concept on incorporating crowd-sourced data to improve landslide hazard model performance. Starting with a national inventory of 90 catalogued landslides in El Salvador for a study period of 1998 to 2011, we simulate the addition of over 600 additional crowd-sourced landslide events that would have been identified through human interpretation of high resolution imagery in the Google Earth time slider feature. There is a noticeable improvement in performance statistics between static heuristic hazard models and probabilistic models that incorporate the events identified by the "crowd." Such a dynamic incorporation of crowd-sourced data on hazard events is not so far-fetched. Given the engagement of "local observers" in El Salvador who augment in situ hydro-meteorological measurements, the growing access to Earth observation data to the lay person, and immense interest behind connecting citizen

  5. Understanding the fate and biological effects of Ag- and TiO2-nanoparticles in the environment: The quest for advanced analytics and interdisciplinary concepts

    International Nuclear Information System (INIS)

    Schaumann, Gabriele E.; Philippe, Allan; Bundschuh, Mirco; Metreveli, George; Klitzke, Sondra; Rakcheev, Denis; Grün, Alexandra

    2015-01-01

    Engineered inorganic nanoparticles (EINP) from consumers' products and industrial applications, especially silver and titanium dioxide nanoparticles (NP), are emitted into the aquatic and terrestrial environments in increasing amounts. However, the current knowledge on their environmental fate and biological effects is diverse and renders reliable predictions complicated. This review critically evaluates existing knowledge on colloidal aging mechanisms, biological functioning and transport of Ag NP and TiO 2 NP in water and soil and it discusses challenges for concepts, experimental approaches and analytical methods in order to obtain a comprehensive understanding of the processes linking NP fate and effects. Ag NP undergo dissolution and oxidation with Ag 2 S as a thermodynamically determined endpoint. Nonetheless, Ag NP also undergo colloidal transformations in the nanoparticulate state and may act as carriers for other substances. Ag NP and TiO 2 NP can have adverse biological effects on organisms. Whereas Ag NP reveal higher colloidal stability and mobility, the efficiency of NOM as a stabilizing agent is greater towards TiO 2 NP than towards Ag NP, and multivalent cations can dominate the colloidal behavior over NOM. Many of the past analytical obstacles have been overcome just recently. Single particle ICP-MS based methods in combination with field flow fractionation techniques and hydrodynamic chromatography have the potential to fill the gaps currently hampering a comprehensive understanding of fate and effects also at a low field relevant concentrations. These analytical developments will allow for mechanistically orientated research and transfer to a larger set of EINP. This includes separating processes driven by NP specific properties and bulk chemical properties, categorization of effect-triggering pathways directing the EINP effects towards specific recipients, and identification of dominant environmental parameters triggering fate and effect of

  6. Understanding the fate and biological effects of Ag- and TiO{sub 2}-nanoparticles in the environment: The quest for advanced analytics and interdisciplinary concepts

    Energy Technology Data Exchange (ETDEWEB)

    Schaumann, Gabriele E., E-mail: schaumann@uni-landau.de [Universität Koblenz-Landau, Institute for Environmental Sciences, Group of Environmental and Soil Chemistry, Fortstr. 7, D-76829 Landau (Germany); Philippe, Allan, E-mail: philippe@uni-landau.de [Universität Koblenz-Landau, Institute for Environmental Sciences, Group of Environmental and Soil Chemistry, Fortstr. 7, D-76829 Landau (Germany); Bundschuh, Mirco, E-mail: mirco.bundschuh@slu.se [Universität Koblenz-Landau, Institute for Environmental Sciences, Group of Ecotoxicology and Environment, Fortstr. 7, D-76829 Landau (Germany); Swedish University of Agricultural Sciences, Department of Aquatic Sciences and Assessment, Lennart Hjelms väg 9, SE-75007 Uppsala (Sweden); Metreveli, George, E-mail: metreveli@uni-landau.de [Universität Koblenz-Landau, Institute for Environmental Sciences, Group of Environmental and Soil Chemistry, Fortstr. 7, D-76829 Landau (Germany); Klitzke, Sondra, E-mail: sondra.klitzke@tu-berlin.de [Albert-Ludwigs-Universität Freiburg, Institute of Forest Sciences, Chair of Soil Ecology, 79085 Freiburg i.Br. (Germany); Berlin University of Technology, Institute of Ecology, Department of Soil Science, Ernst-Reuter-Platz 1, D-10587 Berlin (Germany); Rakcheev, Denis, E-mail: rakcheev@uni-landau.de [Universität Koblenz-Landau, Institute for Environmental Sciences, Group of Environmental and Soil Chemistry, Fortstr. 7, D-76829 Landau (Germany); Grün, Alexandra, E-mail: alexg@uni-koblenz.de [Universität Koblenz-Landau, Institute for Integrated Natural Sciences, Dept. of Biology, Universitätsstr. 1, D-56070 Koblenz (Germany); and others

    2015-12-01

    Engineered inorganic nanoparticles (EINP) from consumers' products and industrial applications, especially silver and titanium dioxide nanoparticles (NP), are emitted into the aquatic and terrestrial environments in increasing amounts. However, the current knowledge on their environmental fate and biological effects is diverse and renders reliable predictions complicated. This review critically evaluates existing knowledge on colloidal aging mechanisms, biological functioning and transport of Ag NP and TiO{sub 2} NP in water and soil and it discusses challenges for concepts, experimental approaches and analytical methods in order to obtain a comprehensive understanding of the processes linking NP fate and effects. Ag NP undergo dissolution and oxidation with Ag{sub 2}S as a thermodynamically determined endpoint. Nonetheless, Ag NP also undergo colloidal transformations in the nanoparticulate state and may act as carriers for other substances. Ag NP and TiO{sub 2} NP can have adverse biological effects on organisms. Whereas Ag NP reveal higher colloidal stability and mobility, the efficiency of NOM as a stabilizing agent is greater towards TiO{sub 2} NP than towards Ag NP, and multivalent cations can dominate the colloidal behavior over NOM. Many of the past analytical obstacles have been overcome just recently. Single particle ICP-MS based methods in combination with field flow fractionation techniques and hydrodynamic chromatography have the potential to fill the gaps currently hampering a comprehensive understanding of fate and effects also at a low field relevant concentrations. These analytical developments will allow for mechanistically orientated research and transfer to a larger set of EINP. This includes separating processes driven by NP specific properties and bulk chemical properties, categorization of effect-triggering pathways directing the EINP effects towards specific recipients, and identification of dominant environmental parameters triggering

  7. Advanced glycation end product (AGE) modified proteins in tears of diabetic patients.

    Science.gov (United States)

    Zhao, Zhenjun; Liu, Jingfang; Shi, Bingyin; He, Shuixiang; Yao, Xiaoli; Willcox, Mark D P

    2010-08-11

    High glucose level in diabetic patients may lead to advanced glycation end product (AGE) modified proteins. This study investigated AGE modified proteins in tears and compared their levels in diabetic patients (DM) with non-diabetic controls (CTL). Basal tears were collected from DM with (DR) or without (DNR) retinopathy and CTL. Total AGE modified proteins were detected quantitatively by a dot immunobinding assay. The AGE modified proteins were separated in 1D- and 2D-SDS gels and detected by western-blotting. The individual AGE modified proteins were also compared between groups using densitometry. Compared with the CTL group, tear concentrations of AGE modified proteins were significantly elevated in DR and DNR groups. The concentration of AGE modified proteins in diabetic tears were positively correlated with AGE modified hemoglobin (HbA1c) and postprandial blood glucose level (PBG). Western blotting of AGE modified proteins from 1D-SDS gels showed several bands, the major one at around 60 kDa. The intensities of AGE modified protein bands were higher in DM tears than in CTL tears. Western blotting from 2D-SDS gels showed a strongly stained horizontal strip, which corresponded to the major band in 1D-SDS gels. Most of the other AGE modified protein species were within molecular weight of 30-60 kDa, PI 5.2-7.0. Densitometry analysis demonstrated several AGE modified proteins were elevated in DR or DNR tears. Total and some individual AGE modified proteins were elevated in DM tears. AGE modified proteins in tears may be used as biomarkers to diagnose diabetes and/or diabetic retinopathy.

  8. Advanced calculus

    CERN Document Server

    Fitzpatrick, Patrick M

    2009-01-01

    Advanced Calculus is intended as a text for courses that furnish the backbone of the student's undergraduate education in mathematical analysis. The goal is to rigorously present the fundamental concepts within the context of illuminating examples and stimulating exercises. This book is self-contained and starts with the creation of basic tools using the completeness axiom. The continuity, differentiability, integrability, and power series representation properties of functions of a single variable are established. The next few chapters describe the topological and metric properties of Euclide

  9. Promiscuous prediction and conservancy analysis of CTL binding epitopes of HCV 3a viral proteome from Punjab Pakistan: an In Silico Approach

    Directory of Open Access Journals (Sweden)

    Idrees Muhammad

    2011-02-01

    Full Text Available Abstract Background HCV is a positive sense RNA virus affecting approximately 180 million people world wide and about 10 million Pakistani populations. HCV genotype 3a is the major cause of infection in Pakistani population. One of the major problems of HCV infection especially in the developing countries that limits the limits the antiviral therapy is the long term treatment, high dosage and side effects. Studies of antigenic epitopes of viral sequences of a specific origin can provide an effective way to overcome the mutation rate and to determine the promiscuous binders to be used for epitope based subunit vaccine design. An in silico approach was applied for the analysis of entire HCV proteome of Pakistani origin, aimed to identify the viral epitopes and their conservancy in HCV genotypes 1, 2 and 3 of diverse origin. Results Immunoinformatic tools were applied for the predictive analysis of HCV 3a antigenic epitopes of Pakistani origin. All the predicted epitopes were then subjected for their conservancy analysis in HCV genotypes 1, 2 and 3 of diverse origin (worldwide. Using freely available web servers, 150 MHC II epitopes were predicted as promiscuous binders against 51 subjected alleles. E2 protein represented the 20% of all the predicted MHC II epitopes. 75.33% of the predicted MHC II epitopes were (77-100% conserve in genotype 3; 47.33% and 40.66% in genotype 1 and 2 respectively. 69 MHC I epitopes were predicted as promiscuous binders against 47 subjected alleles. NS4b represented 26% of all the MHC I predicted epitopes. Significantly higher epitope conservancy was represented by genotype 3 i.e. 78.26% and 21.05% for genotype 1 and 2. Conclusions The study revealed comprehensive catalogue of potential HCV derived CTL epitopes from viral proteome of Pakistan origin. A considerable number of predicted epitopes were found to be conserved in different HCV genotype. However, the number of conserved epitopes in HCV genotype 3 was

  10. Evaluation of the Commitment to Living (CTL) curriculum: a 3-hour training for mental health professionals to address suicide risk.

    Science.gov (United States)

    Pisani, Anthony R; Cross, Wendi F; Watts, Arthur; Conner, Kenneth

    2012-01-01

    Finding effective and efficient options for training mental health professionals to assess and manage suicide risk is a high priority. To test whether an innovative, brief workshop can improve provider knowledge, confidence, and written risk assessment in a multidisciplinary sample of ambulatory and acute services professionals and trainees. We conducted a pre/post evaluation of a 3 h workshop designed to improve clinical competence in suicide risk assessment by using visual concept mapping, medical records documentation, and site-specific crisis response options. Participants (N = 338 diverse mental health professionals) completed pre- and postworkshop questionnaires measuring their knowledge and confidence. Before and after the workshop, participants completed documentation for a clinical vignette. Trained coders rated the quality of risk assessment formulation before and after training. Participants' knowledge, confidence, and objectively-rated documentation skills improved significantly (p management programs can improve clinicians' knowledge, confidence, and skill.

  11. Regulation of CTL responses to MHC-restricted class I peptide of the gp70 tumour antigen by splenic parenchymal CD4+ T cells in mice failing immunotherapy with DISC-mGM-CSF.

    Science.gov (United States)

    Ahmad, Murrium; Rees, Robert C; McArdle, Stephanie E; Li, Geng; Mian, Shahid; Entwisle, Claire; Loudon, Peter; Ali, Selman A

    2005-07-20

    Direct intratumour injection of the disabled infectious single-cycle-herpes simplex virus-encoding murine granulocyte/macrophage colony-stimulating factor (DISC-HSV-mGM-CSF) into established colon carcinoma CT26 tumours induced complete tumour rejection in up to 70% of treated animals (regressors), while the remaining mice developed progressive tumours (progressors). This murine Balb/c model was used to dissect the cellular mechanisms involved in tumour regression or progression following immunotherapy. CTLs were generated by coculturing lymphocytes and parenchymal cells from the same spleens of individual regressor or progressor animals in the presence of the relevant AH-1 peptide derived from the gp70 tumour-associated antigens expressed by CT26 tumours. Tumour regression was correlated with potent CTL responses, spleen weight and cytokine (IFN-gamma) production. Conversely, progressor splenocytes exhibited weak to no CTL activity and poor IFN-gamma production, concomitant with the presence of a suppressor cell population in the progressor splenic parenchymal cell fraction. Further fractionation of this parenchymal subpopulation demonstrated that cells inhibitory to the activation of AH-1-specific CTLs, restimulated in vitro with peptide, were present in the nonadherent parenchymal fraction. In vitro depletion of progressor parenchymal CD3+/CD4+ T cells restored the CTL response of the cocultured splenocytes (regressor lymphocytes and progressor parenchymal cells) and decreased the production of IL-10, suggesting that CD3+CD4+ T lymphocytes present in the parenchymal fraction regulated the CTL response to AH-1. We examined the cellular responses associated with tumour rejection and progression, identifying regulatory pathways associated with failure to respond to immunotherapy. Copyright 2005 Wiley-Liss, Inc.

  12. Tokamak concept innovations

    International Nuclear Information System (INIS)

    1986-04-01

    This document contains the results of the IAEA Specialists' Meeting on Tokamak Concept Innovations held 13-17 January 1986 in Vienna. Although it is the most advanced fusion reactor concept the tokamak is not without its problems. Most of these problems should be solved within the ongoing R and D studies for the next generation of tokamaks. Emphasis for this meeting was placed on innovations that would lead to substantial improvements in a tokamak reactor, even if they involved a radical departure from present thinking

  13. MENINGKATKAN MINAT BELAJAR BIOLOGI MENGGUNAKAN PEMBELAJARAN CTL (Contextual Teaching and Learning PADA SISWA DI KELAS VII-B MTs NEGERI PURWOKERTO

    Directory of Open Access Journals (Sweden)

    Teguh Julianto

    2010-09-01

    Full Text Available Improving Student’s Interest in Biology lesson by using contextual teaching and learning (CLT methods is n action research study which had an aim to improve student’s interest in biology. The indicator of student’s interest covers the student’s diligence in learning process, active in following teaching and learning process, active in doing a task, the facility and the sources of learning. The result of this researched showed that there were an improvement of students learning interest. The percentage result in cycle I was 39.5%, in cycle 2 was 72.67% and in Cycle 3 was 80.92%. The improvement of students learning interests gave a positive effect toward the students achievement. The students learning achievement in cycle 1 I was 39%, in cycle II was 82% and in cycle III was 93%. In conclusion Contextual Teaching and Learning (CLT can improve the students learning interest in Biology at the Second Grade Students of MTs Negeri Purwokerto. Key words : Improving, Student’s learning interest, Contextual Teaching and Learning (CTL

  14. COMET concept

    International Nuclear Information System (INIS)

    Alsmeyer, H.; Tromm, W.

    1995-01-01

    Studies of the COMET core catcher concept developed for a future PWR have been continued. The concept is based on the spreading of a core melt on a sacrificial layer and its erosion, until a subsequent addition of water from below causes a fragmentation of the melt. A porous solidification of the melt would then admit a complete flooding within a short period. (orig.)

  15. Concept Mapping

    Science.gov (United States)

    Technology & Learning, 2005

    2005-01-01

    Concept maps are graphical ways of working with ideas and presenting information. They reveal patterns and relationships and help students to clarify their thinking, and to process, organize and prioritize. Displaying information visually--in concept maps, word webs, or diagrams--stimulates creativity. Being able to think logically teaches…

  16. Management concepts.

    Science.gov (United States)

    Bittner, Rhonda

    2006-01-01

    Management concepts evolve through time. Health care managers can learn new concepts by evaluating classical management strategies, as well as modern-day strategies. Focusing on quality improvement and team building can help managers align the goals of their departments with the goals of the organization, consequently improving patient care.

  17. Lateral Concepts

    DEFF Research Database (Denmark)

    Gad, Christopher; Bruun Jensen, casper

    2016-01-01

    This essay discusses the complex relation between the knowledges and practices of the researcher and his/her informants in terms of lateral concepts. The starting point is that it is not the prerogative of the (STS) scholar to conceptualize the world; all our “informants” do it too. This creates...... the possibility of enriching our own conceptual repertoires by letting them be inflected by the concepts of those we study. In a broad sense, the lateral means that there is a many-to-many relation between domains of knowledge and practice. However, each specific case of the lateral is necessarily immanent...... to a particular empirical setting and form of inquiry. In this sense lateral concepts are radically empirical since it locates concepts within the field. To clarify the meaning and stakes of lateral concepts, we first make a contrast between lateral anthropology and Latour’s notion of infra-reflexivity. We end...

  18. Concept theory

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2009-01-01

      Concept theory is an extremely broad, interdisciplinary and complex field of research related to many deep fields with very long historical traditions without much consensus. However, information science and knowledge organization cannot avoid relating to theories of concepts. Knowledge...... organizing systems (e.g. classification systems, thesauri and ontologies) should be understood as systems basically organizing concepts and their semantic relations. The same is the case with information retrieval systems. Different theories of concepts have different implications for how to construe......, evaluate and use such systems. Based on "a post-Kuhnian view" of paradigms this paper put forward arguments that the best understanding and classification of theories of concepts is to view and classify them in accordance with epistemological theories (empiricism, rationalism, historicism and pragmatism...

  19. Space Mission Concept Development Using Concept Maturity Levels

    Science.gov (United States)

    Wessen, Randii R.; Borden, Chester; Ziemer, John; Kwok, Johnny

    2013-01-01

    Over the past five years, pre-project formulation experts at the Jet Propulsion Laboratory (JPL) has developed and implemented a method for measuring and communicating the maturity of space mission concepts. Mission concept development teams use this method, and associated tools, prior to concepts entering their Formulation Phases (Phase A/B). The organizing structure is Concept Maturity Level (CML), which is a classification system for characterizing the various levels of a concept's maturity. The key strength of CMLs is the ability to evolve mission concepts guided by an incremental set of assessment needs. The CML definitions have been expanded into a matrix form to identify the breadth and depth of analysis needed for a concept to reach a specific level of maturity. This matrix enables improved assessment and communication by addressing the fundamental dimensions (e.g., science objectives, mission design, technical risk, project organization, cost, export compliance, etc.) associated with mission concept evolution. JPL's collaborative engineering, dedicated concept development, and proposal teams all use these and other CML-appropriate design tools to advance their mission concept designs. This paper focuses on mission concept's early Pre-Phase A represented by CMLs 1- 4. The scope was limited due to the fact that CMLs 5 and 6 are already well defined based on the requirements documented in specific Announcement of Opportunities (AO) and Concept Study Report (CSR) guidelines, respectively, for competitive missions; and by NASA's Procedural Requirements NPR 7120.5E document for Projects in their Formulation Phase.

  20. Advanced Nuclear Reactor Concepts for China

    International Nuclear Information System (INIS)

    Knoche, D.; Sassen, F.; Tietsch, W.; Yujie, Dong; Li, Cao

    2008-01-01

    China is one of the fastest growing economies in the world. With 1.3 billion people China also has the largest population worldwide. The growing economy, the migration of people from rural areas to cities and the augmentation in living standard will drive the energy demand of China in the coming decades. At present the installed electrical power is about 500 GW. In the years 2004 and 2005 the added electrical capacity was around 60 GW per year. Chinas primary energy demand is covered mainly by the use of coal. Coal also will remain the main energy source in the coming decades in China. Nevertheless taking into account more and more environmental aspects and the goal to reduce dependencies on energy imports a better energy mix strategy is planed to change including at an increasing level the renewable and nuclear option. Present the nuclear park is characterised by a large variety of different types of reactors. With the AP-1000, EPR and the gas-cooled High Temperature Reactor (HTR) the spectrum of different reactor types will be further enlarged. (authors)

  1. Advanced Microgrid Concepts and Technologies Workshop

    Science.gov (United States)

    2013-04-01

    Prognostics for Microgrid Components—Abhinav Saxena, NASA Ames Research Center...but very expensive; companies: Trek , Omron, SMC, Plessey Semiconductors, Quasar Federal Systems) o Field meters (chopper or rotating vane technology...still relatively expensive and low precision; companies: Monroe, Trek , AlphaLab, Campbell Scientific) • Why do we need anything beyond what is

  2. Digital Recovery Sequencer - Advanced Concept Ejection Seats

    National Research Council Canada - National Science Library

    Ross, David A; Cotter, Lee; Culhane, David; Press, Matthew J

    2005-01-01

    .... Continued usage of the Analog Sequencer is undesirable due to limitations with respect to its installed life, electronic component obsolescence, flexibility to accommodate seat safety improvements...

  3. Advanced propulsion system concept for hybrid vehicles

    Science.gov (United States)

    Bhate, S.; Chen, H.; Dochat, G.

    1980-01-01

    A series hybrid system, utilizing a free piston Stirling engine with a linear alternator, and a parallel hybrid system, incorporating a kinematic Stirling engine, are analyzed for various specified reference missions/vehicles ranging from a small two passenger commuter vehicle to a van. Parametric studies for each configuration, detail tradeoff studies to determine engine, battery and system definition, short term energy storage evaluation, and detail life cycle cost studies were performed. Results indicate that the selection of a parallel Stirling engine/electric, hybrid propulsion system can significantly reduce petroleum consumption by 70 percent over present conventional vehicles.

  4. Advanced concepts in accelerator timing control

    International Nuclear Information System (INIS)

    Frankel, R.; Salwen, C.

    1988-01-01

    The control system for the Booster accelerator presently under construction at BNL includes a timing section with serial high speed coded data distribution, computer based encoders for both real time and field driven clocks and a method of easily tracking the performance and reliability of these timing streams. We have developed a simple method for the generation of timing which operates to produce pulses which may be repeated as desired with minimal latency

  5. Basic concept of QA for advanced technologies

    International Nuclear Information System (INIS)

    Mijnheer, Ben

    2008-01-01

    The lecture was structured as follows: (1) Rationale for accurate dose determination; (2) Existing recommendations and guidance; (3) Challenges within the current QA paradigm; (4) New paradigm adopted by AAPM TG 100; and (5) Application of new paradigm to IMRT. Attention was paid, i.a., to major accidents in radiotherapy such as Epinal-1. (P.A.)

  6. Advanced display concepts in nuclear control rooms

    International Nuclear Information System (INIS)

    Clark, M.T.; Banks, W.W.; Blackman, H.S.; Gertman, D.I.

    1982-01-01

    Precursors necessary for the development of a full-scale predictor display/control system have been under development since the mid 1940's. The predictor display itself has been available for use in manual control systems since 1958. However, the nuclear industry has not yet explored the uses and benefits of predictor systems. The purpose of this paper is to provide information on the application of this technology to the nuclear industry. The possibility of employing a simulation-based control system for nuclear plant systems that currently use conventional auto/manual schemes is discussed. By employing simulation-based systems, a predictor display could be made available to the operator during manual operations, thus facilitating control without outwardly affecting the overall control scheme

  7. Advanced Burner Reactor 1000MWth Reference Concept

    Energy Technology Data Exchange (ETDEWEB)

    Cahalan, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Fanning, T. [Argonne National Lab. (ANL), Argonne, IL (United States); Farmer, M. [Argonne National Lab. (ANL), Argonne, IL (United States); Grandy, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Jin, E. [Argonne National Lab. (ANL), Argonne, IL (United States); Kim, T. [Argonne National Lab. (ANL), Argonne, IL (United States); Kellogg, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Krajtl, L. [Argonne National Lab. (ANL), Argonne, IL (United States); Lomperski, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Moisseytsev, A. [Argonne National Lab. (ANL), Argonne, IL (United States); Momozaki, Y. [Argonne National Lab. (ANL), Argonne, IL (United States); Park, Y. [Argonne National Lab. (ANL), Argonne, IL (United States); Reed, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Salev, F. [Argonne National Lab. (ANL), Argonne, IL (United States); Seidensticker, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Sienicki, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Tang, Y. [Argonne National Lab. (ANL), Argonne, IL (United States); Tzanos, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Wei, T. [Argonne National Lab. (ANL), Argonne, IL (United States); Yang, W. [Argonne National Lab. (ANL), Argonne, IL (United States); Chikazawa, Y. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2007-09-30

    The primary mission of the ABR Program is to demonstrate the transmutation of transuranics recovered from the LWR spent fuel, and hence, to validate the benefits of the fuel cycle closure to nuclear waste management. The transmutation, or burning of the transuranics is accomplished by fissioning and this is most effectively done in a fast spectrum. In the thermal spectrum of commercial LWRs, some transuranics capture neutrons and become even heavier transuranics rather than being fissioned. Even with repeated recycling, only about 30% can be transmuted, which is an intrinsic limitation of all thermal spectrum reactors. Only in a fast spectrum can all transuranics be effectively fissioned to eliminate their long-term radiotoxicity and decay heat.

  8. Advanced Concepts Theory Annual Report 1986.

    Science.gov (United States)

    1987-08-12

    8217(’ . I’ lie o~ f I go veta e Ti TC 1 4 J i t ’’i’i I IIII I I ’e’TT I tlr ’. e I 1tun’ I ll <...i , r i’ alux [l. i i I I t , A 140, . flIT W ,I ’ r F...9 NL EhlhlhhhlhhhhI IIIIIIIIIIIIIIfflfflf EEEEEEEEEEEEEH lllllElllllllE EllllllllhE-EE E /UhiEl/EEEEEI 11111 .0 125 A _j MiCROCOPY RESOLUTIN TEST CHART...ZIPPERING NOZZLE IMPLOSION CHARACTERISTICS AND THEIR IMPORTANCE TO UNIFORMITY IN A Z-PINCH ............................... 42 E . OPENING SWITCH AND

  9. Flight Test of Advanced Digital Control Concepts.

    Science.gov (United States)

    1982-03-01

    34 equations, and this result is then compared against the "model" equations. OPTION :::CREATrE ,CIEY, COFPY, MAT ,AMAT, COIP-YUMAT, BMAT , 74 COPFY, CMAT...BMATY .-COPY, NMAT, AMAT ,72 ,COPY, GMAT, RMA, COP:Y, (MAT, BMA’TCOFY, MA T ,AMAT >74, COPY, CMA’TsmA, PCOPY, RMAT, BmAT , pCOPYVMiAT , AMAo.T 72...COP’Y, MAT, AMAT, >75, COPY , MAtT, BMAT , COPY, ZMAT, AMAT, 74 ,COP’Y, MAT, TMAT, COPY, VMAT, AMAT, .:COPY ,RMAiT, MAT,73,COPW GMAT, E4MAT, COP-"YTMAT

  10. Advanced Nuclear Reactor Concepts for China

    Energy Technology Data Exchange (ETDEWEB)

    Knoche, D.; Sassen, F.; Tietsch, W. [Westinghouse Electric Germany, Postfach 10 05 63, 68140 Mannheim (Germany); Yujie, Dong; Li, Cao [INET, Tsinghua University, 100084 Beijing (China)

    2008-07-01

    China is one of the fastest growing economies in the world. With 1.3 billion people China also has the largest population worldwide. The growing economy, the migration of people from rural areas to cities and the augmentation in living standard will drive the energy demand of China in the coming decades. At present the installed electrical power is about 500 GW. In the years 2004 and 2005 the added electrical capacity was around 60 GW per year. Chinas primary energy demand is covered mainly by the use of coal. Coal also will remain the main energy source in the coming decades in China. Nevertheless taking into account more and more environmental aspects and the goal to reduce dependencies on energy imports a better energy mix strategy is planed to change including at an increasing level the renewable and nuclear option. Present the nuclear park is characterised by a large variety of different types of reactors. With the AP-1000, EPR and the gas-cooled High Temperature Reactor (HTR) the spectrum of different reactor types will be further enlarged. (authors)

  11. Travelling Concepts

    DEFF Research Database (Denmark)

    Simonsen, Karen-Margrethe

    2013-01-01

    Review of "Travelling Concepts, Metaphors, and Narratives: Literary and Cultural Studies in an Age of Interdisciplinary Research" ed. by Sibylle Baumgarten, Beatrice Michaelis and Ansagar Nünning, Trier; Wissenschaftlicher Verlag Trier, 2012......Review of "Travelling Concepts, Metaphors, and Narratives: Literary and Cultural Studies in an Age of Interdisciplinary Research" ed. by Sibylle Baumgarten, Beatrice Michaelis and Ansagar Nünning, Trier; Wissenschaftlicher Verlag Trier, 2012...

  12. Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

    Directory of Open Access Journals (Sweden)

    Aurélie Durgeau

    2018-01-01

    Full Text Available Recent advances in cancer treatment have emerged from new immunotherapies targeting T-cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA-4 and programmed cell death (PD-1. In this context, anti-CTLA-4 and anti-PD-1 monoclonal antibodies have demonstrated survival benefits in numerous cancers, including melanoma and non-small-cell lung carcinoma. PD-1-expressing CD8+ T lymphocytes appear to play a major role in the response to these immune checkpoint inhibitors (ICI. Cytotoxic T lymphocytes (CTL eliminate malignant cells through recognition by the T-cell receptor (TCR of specific antigenic peptides presented on the surface of cancer cells by major histocompatibility complex class I/beta-2-microglobulin complexes, and through killing of target cells, mainly by releasing the content of secretory lysosomes containing perforin and granzyme B. T-cell adhesion molecules and, in particular, lymphocyte-function-associated antigen-1 and CD103 integrins, and their cognate ligands, respectively, intercellular adhesion molecule 1 and E-cadherin, on target cells, are involved in strengthening the interaction between CTL and tumor cells. Tumor-specific CTL have been isolated from tumor-infiltrating lymphocytes and peripheral blood lymphocytes (PBL of patients with varied cancers. TCRβ-chain gene usage indicated that CTL identified in vitro selectively expanded in vivo at the tumor site compared to autologous PBL. Moreover, functional studies indicated that these CTL mediate human leukocyte antigen class I-restricted cytotoxic activity toward autologous tumor cells. Several of them recognize truly tumor-specific antigens encoded by mutated genes, also known as neoantigens, which likely play a key role in antitumor CD8 T-cell immunity. Accordingly, it has been shown that the presence of T lymphocytes directed toward tumor neoantigens is associated with patient response to immunotherapies, including ICI, adoptive cell transfer

  13. B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21

    Science.gov (United States)

    Hagn, Magdalena; Blackwell, Sue E.; Beyer, Thamara; Ebel, Verena; Fabricius, Dorit; Lindner, Stefanie; Stilgenbauer, Stefan; Simmet, Thomas; Tam, Constantine; Neeson, Paul; Trapani, Joseph A.; Schrezenmeier, Hubert; Weiner, George J.

    2014-01-01

    CpG oligodeoxynucleotides (CpG) and IL-21 are two promising agents for the treatment of B-cell chronic lymphocytic leukemia (B-CLL). Recently, we reported that the combination of CpG and IL-21 (CpG/IL-21) can induce granzyme B (GrB)-dependent apoptosis in B-CLL cells. Here, we demonstrate that treatment of B-CLL cells with CpG and IL-21 results in the development of antigen-presenting cell (APC)-like cells with cytotoxic features. These properties eventually give rise to B-CLL cell apoptosis, independently of their cytogenetic phenotype, whereas normal B-cell survival is not negatively affected by CpG/IL-21. APC- and CTL-typical molecules found to be up-regulated in CpG/IL-21-stimulated B-CLL cells include GrB, perforin, T-bet, monokine-induced by IFN-γ and IFN-γ-inducible protein 10 (IP-10), as well as molecules important for cell adhesion, antigen cross-presentation and costimulation. Also induced are molecules involved in GrB induction, trafficking and processing, whereas the GrB inhibitor Serpin B9 [formerly proteinase inhibitor-9 (PI-9)] is down-modulated by CpG/IL-21. In conclusion, CpG/IL-21-stimulated B-CLL cells acquire features that are reminiscent of killer dendritic cells, and which result in enhanced immunogenicity, cytotoxicity and apoptosis. Our results provide novel insights into the aberrant immune state of B-CLL cells and may establish a basis for the development of an innovative cellular vaccination approach in B-CLL. PMID:24497611

  14. Residue analysis of a CTL epitope of SARS-CoV spike protein by IFN-gamma production and bioinformatics prediction

    Directory of Open Access Journals (Sweden)

    Huang Jun

    2012-09-01

    Full Text Available Abstract Background Severe acute respiratory syndrome (SARS is an emerging infectious disease caused by the novel coronavirus SARS-CoV. The T cell epitopes of the SARS CoV spike protein are well known, but no systematic evaluation of the functional and structural roles of each residue has been reported for these antigenic epitopes. Analysis of the functional importance of side-chains by mutational study may exaggerate the effect by imposing a structural disturbance or an unusual steric, electrostatic or hydrophobic interaction. Results We demonstrated that N50 could induce significant IFN-gamma response from SARS-CoV S DNA immunized mice splenocytes by the means of ELISA, ELISPOT and FACS. Moreover, S366-374 was predicted to be an optimal epitope by bioinformatics tools: ANN, SMM, ARB and BIMAS, and confirmed by IFN-gamma response induced by a series of S358-374-derived peptides. Furthermore, each of S366-374 was replaced by alanine (A, lysine (K or aspartic acid (D, respectively. ANN was used to estimate the binding affinity of single S366-374 mutants to H-2 Kd. Y367 and L374 were predicated to possess the most important role in peptide binding. Additionally, these one residue mutated peptides were synthesized, and IFN-gamma production induced by G368, V369, A371, T372 and K373 mutated S366-374 were decreased obviously. Conclusions We demonstrated that S366-374 is an optimal H-2 Kd CTL epitope in the SARS CoV S protein. Moreover, Y367, S370, and L374 are anchors in the epitope, while C366, G368, V369, A371, T372, and K373 may directly interact with TCR on the surface of CD8-T cells.

  15. Basic concepts

    International Nuclear Information System (INIS)

    Dorner, B.

    1999-01-01

    The basic concepts of neutron scattering as a tool for studying the structure and the dynamics of condensed matter. Theoretical aspects are outlined, the two different cases of coherent and incoherent scattering are presented. The issue of resolution, coherence volume and the role of monochromators are also discussed. (K.A.)

  16. Simple Concepts

    Czech Academy of Sciences Publication Activity Database

    Materna, Pavel

    2013-01-01

    Roč. 28, č. 3 (2013), s. 295-319 ISSN 0353-5150 R&D Projects: GA ČR(CZ) GAP401/10/0792 Institutional support: RVO:67985955 Keywords : concept * constructions * set-theoretical paradigm Subject RIV: AA - Philosophy ; Religion

  17. The effect of application of contextual teaching and learning (CTL model-based on lesson study with mind mapping media to assess student learning outcomes on chemistry on colloid systems

    Directory of Open Access Journals (Sweden)

    Annisa Fadillah

    2017-08-01

    Full Text Available The research was conducted to determine the effect of the application of CTL learning model based on lesson study with mind mapping media to the learning outcomes of students on colloid systems. The population of this research was all students of grade XI of SMA N 1 Sunggal. The sample was taken using on the purposive random sampling. The Experiment class was taught with Contextual Teaching and Learning (CTL model based on Lesson Study with Mind Mapping media and the control class taught with conventional learning model. The data was collected using an objective test was consisting of 20 questions which validity, reliability, level of difficulty and power of difference had been tested. T test results showed that tcalculate = 2.1 and ttable = 1.6697 thus tcalculate> ttable which means that Ha is accepted and Ho is rejected. The enhancement of the student learning outcomes showed that the results of experiment class are g = 72.88%, while the control class is 68.97%. From the percentage, it can be seen that learning outcomes of the experiment class are greater than the control class. The analysis of developing cognitive aspects pointed out that C1 = 70.02%, C2 = 73.58%, C3 = 68.63%, Thus the domain of cognitive level are on the cognitive aspects of C2. The result of Lesson Study Analysis showed the results of 71.09% at the first lesson and 88.28% at the second lesson. It means that there is increasing adherence to the indicators after two lessons. Based on the above results, it can be concluded that the result of studying chemistry of the students of class XI of SMA Negeri I Sunggal TA 2014/2015 taught by a CTL model based  on Lesson Study with Mind Mapping media was higher (72.88% than those taught by conventional learning models (68.97% in the subject matter of colloids System.

  18. Isolation of antigenic substances from HIV-1 envelope gp160 gene transfectants by mild acid elution and X-irradiation treatment. For the development of CTL-based immunotherapy

    International Nuclear Information System (INIS)

    Fujimoto, Chiaki; Nakagawa, Yohko; Shimizu, Masumi; Ohara, Kunitoshi; Takahashi, Hidemi

    2003-01-01

    Cytotoxic T lymphocytes (CTLs) play a central role in a broad spectrum of tumor immunity. Such CTLs generally recognize processed antigenic fragments in association with class I major histocompatibility complex (MHC) molecules. Thus, it is important to identify naturally processed antigens associated with class I MHC molecules to generate and activate antigen-specific CTLs. Those processed antigens fitted in the groove of class I MHC molecules are fixed by the β2-microglobulin. Mild acid elution is one method used to isolate antigenic fragments from class I MHC molecules on tumor cells by unfastening a clasp of β2-microglobulin, a critical component for stabilizing class I MHC molecules on the cell surface. Indeed, after the mild acid treatment, the expression of class I MHC molecules was temporarily down-modulated and a strong antigenic fraction for CTL recognition was obtained. To our surprise, such down-modulation of class I MHC molecule expression was also observed when the tumor cells were irradiated. Therefore, using human immunodeficiency virus type I (HIV-1) gp160 env gene transfectants, we examined the effect of X-irradiation on releasing the loaded antigenic fragments. Functional extracts were obtained from X-irradiated cell supernatants that sensitized syngeneic fibroblasts for specific CTL recognition, suggesting that X-irradiation extracts would also contain known antigenic epitopes. These results indicate that, in addition to the conventional mild acid elution treatment, X-irradiation method shown in this paper may provide a new approach for CTL-based vaccine development via isolating antigenic molecules from various tumors or virally infected cells. (author)

  19. Advancing Democratic Leadership through Critical Theory.

    Science.gov (United States)

    Lees, Kimberly A.

    1995-01-01

    Examines how the concepts advanced by critical theorists exemplify democratic leadership. The concept of democratic leadership is explored as a moral imperative of human issues, and the implications of leadership behavior that emulate the principles of democracy are discussed. (SLD)

  20. Astrophysical Concepts

    CERN Document Server

    Harwit, Martin

    2006-01-01

    This classic text, aimed at senior undergraduates and beginning graduate students in physics and astronomy, presents a wide range of astrophysical concepts in sufficient depth to give the reader a quantitative understanding of the subject. Emphasizing physical concepts, the book outlines cosmic events but does not portray them in detail: it provides a series of astrophysical sketches. For this fourth edition, nearly every part of the text has been reconsidered and rewritten, new sections have been added to cover recent developments, and others have been extensively revised and brought up to date. The book begins with an outline of the scope of modern astrophysics and enumerates some of the outstanding problems faced in the field today. The basic physics needed to tackle these questions are developed in the next few chapters using specific astronomical processes as examples. The second half of the book enlarges on these topics and shows how we can obtain quantitative insight into the structure and evolution of...

  1. Introductory concepts

    International Nuclear Information System (INIS)

    Barnes, W.E.

    1983-01-01

    Physical theories are commonly classified as being either ''classical'' or ''modern''. The reasons for this distinction are both historical and substantive. Limited in the sophistication of their measuring instruments, early scientists proposed theories appropriate for the description of the simplest and most accessible physical phenomena, e.g., the trajectories of the planets. Because of the class of phenomena observed, certain beliefs came to underlie all classical theories with regard to the nature of time, space, matter, etc. For example, the idea was undisputed that an object has at all times both a definite position and velocity. Not until the interior of the atom and the nature of electromagnetic radiation were explored was it discovered that the concepts of classical physics are inadequate to deal with many phenomena. A reassessment of fundamental postulates led to the formulation of modern physics which, it is believed, successfully treats the behavior of all physical systems. To gain an understanding of the rudiments of modern physics, one proceeds as the early scientists did by first mastering the classical concepts that emerge from their intuitive picture of the world. Modifications of these concepts are subsequently introduced which allow a more accurate treatment of physical phenomena, particularly atomic and nuclear systems

  2. The Effect of Contextual Teaching and Learning Combined with Peer Tutoring towards Learning Achievement on Human Digestive System Concept

    Directory of Open Access Journals (Sweden)

    Farhah Abadiyah

    2017-11-01

    Full Text Available This research aims to know the influence of contextual teaching and learning (CTL combined with peer tutoring toward learning achievement on human digestive system concept. This research was conducted at one of State Senior High School in South Tangerang in the academic year of 2016/2017. The research method was quasi experiment with nonequivalent pretest-postest control group design. The sample was taken by simple random sampling. The total of the sampels were 86 students which consisted of 44 students as a controlled group and 42 students as an experimental group. The research instrument was objective test which consisted of 25 multiple choice items of each pretest and posttest. The research also used observation sheets for teacher and students activity. The result of data analysis using t-test on the two groups show that the value of tcount was 2.40 and ttable was 1.99 on significant level α = 0,05, so that tcount > ttable.. This result indicated that there was influence of contextual teaching and learning (CTL combined with peer tutoring toward learning achievement on human digestive system concept.

  3. Editorial: Advanced learning technologies

    Directory of Open Access Journals (Sweden)

    Yu-Ju Lan

    2012-03-01

    Full Text Available Recent rapid development of advanced information technology brings high expectations of its potential to improvement and innovations in learning. This special issue is devoted to using some of the emerging technologies issues related to the topic of education and knowledge sharing, involving several cutting edge research outcomes from recent advancement of learning technologies. Advanced learning technologies are the composition of various related technologies and concepts such as mobile technologies and social media towards learner centered learning. This editorial note provides an overview of relevant issues discussed in this special issue.

  4. Method of an integrated and advanced evaluation of vulnerability. Conceptional-methodical fundamentals and examplary implementation for the water household, power generation and energetic utilisation of wood under climatic change; Methode einer integrierten und erweiterten Vulnerabilitaetsbewertung. Konzeptionell-methodische Grundlagen und exemplarische Umsetzung fuer Wasserhaushalt, Stromerzeugung und energetische Nutzung von Holz unter Klimawandel

    Energy Technology Data Exchange (ETDEWEB)

    Weisz, Helga; Koch, Hagen; Lasch, Petra [Potsdam-Institut fuer Klimafolgenforschung e.V. (Germany)] [and others

    2013-07-15

    Actually, in Germany there are more than hundred investigations on the consequences of the climatic change. It is difficult to evaluate the vulnerability of Germany against the climatic change. Under this aspect, the authors of the contributions report on a method of an integrated and advanced evaluation of vulnerability: Conceptional-methodical fundamentals and exemplary implementation for water household, power generation and energetic utilization of wood under climatic change.

  5. Microwave and particle beam sources and directed energy concepts

    International Nuclear Information System (INIS)

    Brandt, H.E.

    1989-01-01

    This book containing the proceedings of the SPIE on microwave and particle beam sources and directed energy concepts. Topics covered include: High power microwave sources, Direct energy concepts, Advanced accelerators, and Particle beams

  6. Advanced Hydrogen Turbine Development

    Energy Technology Data Exchange (ETDEWEB)

    Marra, John [Siemens Energy, Inc., Orlando, FL (United States)

    2015-09-30

    Under the sponsorship of the U.S. Department of Energy (DOE) National Energy Technology Laboratories, Siemens has completed the Advanced Hydrogen Turbine Development Program to develop an advanced gas turbine for incorporation into future coal-based Integrated Gasification Combined Cycle (IGCC) plants. All the scheduled DOE Milestones were completed and significant technical progress was made in the development of new technologies and concepts. Advanced computer simulations and modeling, as well as subscale, full scale laboratory, rig and engine testing were utilized to evaluate and select concepts for further development. Program Requirements of: A 3 to 5 percentage point improvement in overall plant combined cycle efficiency when compared to the reference baseline plant; 20 to 30 percent reduction in overall plant capital cost when compared to the reference baseline plant; and NOx emissions of 2 PPM out of the stack. were all met. The program was completed on schedule and within the allotted budget

  7. Advanced composite structural concepts and materials technologies for primary aircraft structures: Advanced material concepts

    Science.gov (United States)

    Lau, Kreisler S. Y.; Landis, Abraham L.; Chow, Andrea W.; Hamlin, Richard D.

    1993-01-01

    To achieve acceptable performance and long-term durability at elevated temperatures (350 to 600 F) for high-speed transport systems, further improvements of the high-performance matrix materials will be necessary to achieve very long-term (60,000-120,000 service hours) retention of mechanical properties and damage tolerance. This report emphasizes isoimide modification as a complementary technique to semi-interpenetrating polymer networks (SIPN's) to achieve greater processibility, better curing dynamics, and possibly enhanced thermo-mechanical properties in composites. A key result is the demonstration of enhanced processibility of isoimide-modified linear and thermo-setting polyimide systems.

  8. Molten salt reactor concept

    International Nuclear Information System (INIS)

    Sood, D.D.

    1980-01-01

    Molten salt reactor is an advanced breeder concept which is suited for the utilization of thorium for nuclear power production. This reactor is based on the use of solutions of uranium or plutonium fluorides in LiF-BeF 2 -ThF 4 as fuel. Unlike the conventional reactors, no external coolant is used in the reactor core and the fuel salt itself is circulated through heat exchangers to transfer the fission produced heat to a secondary salt (NaF-NaBF 4 ) for steam generation. A part of the fuel stream is continuously processed to isolate 233 Pa, so that it can decay to fissile 233 U without getting converted to 234 Pa, and for the removal of neutron absorbing fission products. This on-line processing scheme makes this reactor concept to achieve a breeding ratio of 1.07 which is the highest for any thermal breeder reactor. Experimental studies at the Bhabha Atomic Research Centre, Bombay, have established the use of plutonium as fuel for this reactor. This molten salt reactor concept is described and the work conducted at the Bhabha Atomic Research Centre is summarised. (auth.)

  9. Using Concept Maps in Political Science

    Science.gov (United States)

    Chamberlain, Robert P.

    2015-01-01

    Concept mapping is a pedagogical technique that was developed in the 1970s and is being used in K-12 and postsecondary education. Although it has shown excellent results in other fields, it is still rare in political science. In this research note, I discuss the implementation and testing of concept mapping in my Advanced Introduction to…

  10. Mathematical concepts

    CERN Document Server

    Jost, Jürgen

    2015-01-01

    The main intention of this book is to describe and develop the conceptual, structural and abstract thinking of mathematics. Specific mathematical structures are used to illustrate the conceptual approach; providing a deeper insight into mutual relationships and abstract common features. These ideas are carefully motivated, explained and illustrated by examples so that many of the more technical proofs can be omitted. The book can therefore be used: ·         simply as an overview of the panorama of mathematical structures and the relations between them, to be supplemented by more detailed texts whenever you want to acquire a working knowledge of some structure ·         by itself as a first introduction to abstract mathematics ·         together with existing textbooks, to put their results into a more general perspective ·         to gain a new and hopefully deeper perspective after having studied such textbooks Mathematical Concepts has a broader scope and is less detaile...

  11. Leading change: a concept analysis.

    Science.gov (United States)

    Nelson-Brantley, Heather V; Ford, Debra J

    2017-04-01

    To report an analysis of the concept of leading change. Nurses have been called to lead change to advance the health of individuals, populations, and systems. Conceptual clarity about leading change in the context of nursing and healthcare systems provides an empirical direction for future research and theory development that can advance the science of leadership studies in nursing. Concept analysis. CINAHL, PubMed, PsycINFO, Psychology and Behavioral Sciences Collection, Health Business Elite and Business Source Premier databases were searched using the terms: leading change, transformation, reform, leadership and change. Literature published in English from 2001 - 2015 in the fields of nursing, medicine, organizational studies, business, education, psychology or sociology were included. Walker and Avant's method was used to identify descriptions, antecedents, consequences and empirical referents of the concept. Model, related and contrary cases were developed. Five defining attributes of leading change were identified: (a) individual and collective leadership; (b) operational support; (c) fostering relationships; (d) organizational learning; and (e) balance. Antecedents were external or internal driving forces and organizational readiness. The consequences of leading change included improved organizational performance and outcomes and new organizational culture and values. A theoretical definition and conceptual model of leading change were developed. Future studies that use and test the model may contribute to the refinement of a middle-range theory to advance nursing leadership research and education. From this, empirically derived interventions that prepare and enable nurses to lead change to advance health may be realized. © 2016 John Wiley & Sons Ltd.

  12. Advanced number theory

    CERN Document Server

    Cohn, Harvey

    1980-01-01

    ""A very stimulating book ... in a class by itself."" - American Mathematical MonthlyAdvanced students, mathematicians and number theorists will welcome this stimulating treatment of advanced number theory, which approaches the complex topic of algebraic number theory from a historical standpoint, taking pains to show the reader how concepts, definitions and theories have evolved during the last two centuries. Moreover, the book abounds with numerical examples and more concrete, specific theorems than are found in most contemporary treatments of the subject.The book is divided into three parts

  13. Advanced teleoperation in nuclear applications

    International Nuclear Information System (INIS)

    Hamel, W.R.; Feldman, M.J.; Martin, H.L.

    1984-01-01

    A new generation of integrated remote maintenance systems is being developed to meet the needs of future nuclear fuel reprocessing at the Oak Ridge National Laboratory. Development activities cover all aspects of an advanced teleoperated maintenance system with particular emphasis on a new force-reflecting servomanipulator concept. The new manipulator, called the advanced servomanipulator, is microprocessor controlled and is designed to achieve force-reflection performance near that of mechanical master/slave manipulators. The advanced servomanipulator uses a gear-drive transmission which permits modularization for remote maintainability (by other advanced servomanipulators) and increases reliability. Human factors analysis has been used to develop an improved man/machine interface concept based upon colorgraphic displays and menu-driven tough screens. Initial test and evaluation of two advanced servomanipulator slave arms and several other development components have begun. 9 references, 5 figures

  14. Advanced Ceramics

    International Nuclear Information System (INIS)

    1989-01-01

    The First Florida-Brazil Seminar on Materials and the Second State Meeting about new materials in Rio de Janeiro State show the specific technical contribution in advanced ceramic sector. The others main topics discussed for the development of the country are the advanced ceramic programs the market, the national technic-scientific capacitation, the advanced ceramic patents, etc. (C.G.C.) [pt

  15. Advances by the Integral Fast Reactor Program

    International Nuclear Information System (INIS)

    Lineberry, M.J.; Pedersen, D.R.; Walters, L.C.; Cahalan, J.E.

    1991-01-01

    The advances by the Integral Fast Reactor Program at Argonne National Laboratory are the subject of this paper. The Integral Fast Reactor (IFR) is an advanced liquid-metal-cooled reactor concept being developed at Argonne National Laboratory. The advances stressed in the paper include fuel irradiation performance, improved passive safety, and the development of a prototype fuel cycle facility. 14 refs

  16. Concepts in surface physics

    CERN Document Server

    Desjonquères, M -C

    1993-01-01

    This textbook is intended as an introduction to surface science for graduate students. It began as a course of lectures that we gave at the University of Paris (Orsay). Its main objectives are twofold: to provide the reader with a compre­ hensive presentation of the basic principles and concepts of surface physics and to show the usefulness of these concepts in the real world by referring to experiments. It starts at a rather elementary level since it only requires a knowledge of solid state physics, quantum mechanics, thermodynamics and statistical physics which does not exceed the background usually taught to students early in their university courses. However, since it finally reaches an advanced level, we have tried to render it as self-contained as possible so that it remains accessible even to an unexperienced reader. Furthermore, the emphasis has been put on a pedagogical level rather than on a technical level. In this spirit, whenever possible, models which are simplified, but which contain the featu...

  17. PRSEUS Structural Concept Development

    Science.gov (United States)

    Velicki, Alex; Jegley, Dawn

    2014-01-01

    A lighter, more robust airframe is one of the key technological advancements necessary for the successful launch of any large next-generation transport aircraft. Such a premise dictates that considerable improvements beyond current state-of-the-art aluminum structures is needed, and that improvements of this magnitude will require an extensive use of composite materials that are not only lightweight, but also economical to produce. To address this challenge, researchers at NASA and The Boeing Company are developing a novel structural concept called the Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) under the Environmentally Responsible Aviation (ERA) Project. It is an integrally stiffened panel concept that is stitched together and designed to maintain residual load-carrying capabilities under a variety of damage scenarios. In addition to improved structural performance, an important facet of this unique arrangement of stitched carbon fibers is its innovative manufacturing method that has the potential to lower fabrication costs by eliminating fasteners and autoclave cures. The rationale and development status for this new approach forms the basis of the work described in this paper. The test specimens described herein were fabricated, or are currently being fabricated, by The Boeing Company, while the structural analyses and testing tasks are being performed by NASA and Boeing personnel.

  18. Advanced intelligence and mechanism approach

    Institute of Scientific and Technical Information of China (English)

    ZHONG Yixin

    2007-01-01

    Advanced intelligence will feature the intelligence research in next 50 years.An understanding of the concept of advanced intelligence as well as its importance will be provided first,and detailed analysis on an approach,the mechanism approach.suitable to the advanced intelligence research will then be flolowed.And the mutual relationship among mechanism approach,traditional approaches existed in artificial intelligence research,and the cognitive informatics will be discussed.It is interesting to discover that mechanism approach is a good one to the Advanced Intelligence research and a tmified form of the existed approaches to artificial intelligence.

  19. Mini Literature Review of Self-Concept

    Directory of Open Access Journals (Sweden)

    Aida Mehrad

    2016-08-01

    Full Text Available The aim of the current literature review is to focus on individuals´ self-concept. The results of the present study reveal that self-concept assumed as an important factor for each and can change his or her belief, attitude, and reaction toward personal and social life. This study likewise explained the beginning of self-concept, different views toward this vital factor, the role of introspection, and multicultural. Furthermore, this paper supported the imperative of self-concept; additionally, it has an essential role in individual advance.

  20. Advances in solar sailing

    CERN Document Server

    Third International Symposium on Solar Sailing

    2014-01-01

    Hosted by the Advanced Space Concepts Laboratory within the department of Mechanical and Aerospace Engineering of the University of Strathclyde, the third International Symposium on Solar Sailing was held in McCance Building at 16 Richmond Street, Glasgow, between 11 and 13 June 2013. The symposium attracted over 90 delegates from19 different counties, bringing together international experts from across the globe to discuss funded solar sail flight programs alongside on-going technology development and testing programs. The symposium also provided a forum for the discussion of enabling technologies, new application concepts, materials and structural concepts, space environmental effects, dynamics, navigation, control, and much more. This volume contains the unabridged symposium proceedings, in the gathered experts own words. As symposium chair, I thank our partners at Scottish Enterprise and L’Garde, Inc., the symposium’s gold sponsor, for their support in realising this symposium.