WorldWideScience

Sample records for csu valsts imnzija

  1. Valsts policijas budžeta analīze

    OpenAIRE

    Spūle, Lāsma

    2014-01-01

    Valsts policijas pamatbudžeta strukturālais sadalījums ir neatņemama Iekšlietu ministrijas kopējā budžeta sastāvdaļa. Ikviena plānošanas darbība ietekmē kopējā budžeta izstrādi, lai atspoguļotu valsts budžeta iestāžu darbību, tika analizēta Valsts policijas budžeta struktūra, tā sastādīšanas un izpildes nepilnības. Maģistra darba mērķis ir analizēt Valsts policijas budžetu, ar tā veidošanu un izlietošanu saistītās problēmas, kā arī izstrādāt priekšlikumus Valsts policijas budžeta procesa u...

  2. Beam Position Monitoring in the CSU Accelerator Facility

    Science.gov (United States)

    Einstein, Joshua; Vankeuren, Max; Watras, Stephen

    2014-03-01

    A Beam Position Monitoring (BPM) system is an integral part of an accelerator beamline, and modern accelerators can take advantage of newer technologies and designs when creating a BPM system. The Colorado State University (CSU) Accelerator Facility will include four stripline detectors mounted around the beamline, a low-noise analog front-end, and digitization and interface circuitry. The design will support a sampling rate greater than 10 Hz and sub-100 μm accuracy.

  3. Sustainability in Higher Education through the Perspective of CSU Campus Presidents

    Science.gov (United States)

    Christov, Ellie

    2016-01-01

    Institutions of Higher Education (IHEs) play a central role in global efforts toward environmental sustainability. With 23 campuses, the California State University (CSU) is the largest higher education system in the world. The CSU graduates over 100,000 students annually and significantly contributes to developing the workforce of the state and…

  4. Informācijas drošības pārvaldība valsts pārvaldes iestādē

    OpenAIRE

    Zonnenberga-Zamberga, Zane

    2010-01-01

    Bakalaura darbā „Informācijas drošības pārvaldība valsts pārvaldes iestādē” mērķis ir aprakstīti valsts pārvaldes normatīvos aktus un likumus, kas tiek izmantoti informācijas sistēmas izveidošanai, atbilstoši Latvijas likumdošanai, apskatīti pasaules standarti, izveidota drošības politika un aprakstīt ar to saistītā informācija (sistēmas realizācijas plāns, ieviešanas procesi, informācijas riska pakāpes, sistēmas drošības kritēriji u.c.). Darba gaitā tiek izvērtētas iespējamās problēmas, k...

  5. BASE Temperature Data Record (TDR) from the SSM/I and SSMIS Sensors, CSU Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The BASE Temperature Data Record (TDR) dataset from Colorado State University (CSU) is a collection of the raw unprocessed antenna temperature data that has been...

  6. Valsts nozīme no atjaunojamajiem energoresursiem ražotas elektroenerģijas attīstības veicināšanā

    OpenAIRE

    Deniņa, A; Zvanītājs, J

    2010-01-01

    Raksta mērķis ir identificēt no atjaunojamiem energoresursiem ražotas elektroenerģijas ekonomiskos un vides ieguvumus; skaidrot valsts nozīmi šādas elektroenerģijas attīstības veicināšanā caur atbalsta instrumentiem, ņemot vērā tās ražošanas un investīciju izmaksas, kā arī sniegt visaptverošu atbalsta instrumentu klasifikāciju. Rakstā secināts, ka valstij ir noteicošā loma RES-e ražošanas attīstības veicināšanā un tāda ekonomiskā atbalsta līmeņa nodrošināšanā, kas nodrošina pietiekamu invest...

  7. LGBT tiesību attīstība Baltijas valstīs salīdzinājumā ar politiskajiem procesiem

    OpenAIRE

    Āboliņa, Ance

    2013-01-01

    Darbā aplūkota LGBT tiesību attīstība Baltijas valstīs kopš neatkarības atjaunošanas. Tika izvēlēts pētīt tieši LGBT tiesības, jo šī diskriminācijas forma ir viena no visaugstākajām ES. Mērķis ir noskaidrot, vai veiktās izmaiņas likumos ir dēļ valstu vēlmes pievienoties ES. Tika apskatīts gan nosacījumu kopums, kas jāizpilda iestājoties ES, gan arī kādi likumi tika grozīti un kad, kā arī viedokļu izpausmes sabiedrībā. Tika secināts, ka likuma grozījumi ir veikti dēļ ES nosacījumu izpildes, ta...

  8. Automašīnu valsts reģistrācijas numuru atpazīšana Android operētājsistēmā

    OpenAIRE

    2014-01-01

    Autoceļu, auto stāvvietu un automobiļu drošību un efektivitāti iespējams uzlabot ar automātisko valsts reģistrācijas numuru atzīšanu. Šāda sistēma ir efektīva uzņēmumos, kuri veic autotransporta pārraudzību un inspekcijas, lai ātri identificētu automašīnu pēc tās numura. Sistēmas mobilitāte un spēja darboties uz planšetdatora vai viedtālruņa ļautu palielināt tās efektivitāti. Šī darba mērķis ir izpētīt šajā jomā pieejamus risinājumus un rīkus, salīdzināt tos, kā arī izstrādāt savu risinājumu,...

  9. NOAA Climate Data Record (CDR) of SSM/I and SSMIS Microwave Brightness Temperatures, CSU Version 1

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) from Colorado State University (CSU) contains brightness temperatures that have been improved and quality-controlled over the...

  10. The undergraduate physics tutorial program at CSU Los Angeles assessment of utility and areas of interest

    Science.gov (United States)

    Avetyan, Smbat

    The Physics Education Research (PER) group at the University of Washington have researched traditional teaching methods and found that students in introductory physics are lacking a conceptual understanding of the physics material. The solution they put forth is an interactive tutorial program designed to meet the lack of conceptual understanding. Since the tutorial programs inception at CSU Los Angeles in Fall 2006 no evaluation has been successfully undertaken therefore the effect of the tutorial program in the physics 200 series is deeply obscure to the department. The research has shed light on the tutorial program and brought into context its effectiveness on the overall physics 200 series courses at CSU Los Angeles. The researcher has addressed the following research questions, what overall effect does the tutorial program have on the Physics 200 series curriculum? What is the size and significance of gains attributable to the undergraduate calculus based Physics 200 series tutorial program at CSU Los Angeles? What can we learn from gains about individual weekly lessons from the Physics 200 series tutorial courses? What is the correlation of tutorial gains with student final course grades? Are the gains from the tutorial program different for genders? Is there a difference in gains based on the different students' colleges?

  11. Apmācības iespējas Valsts probācijas dienestā darbiniekiem un ieteikumi tās uzlabošanai

    OpenAIRE

    Bulatčika, Anastasija

    2014-01-01

    Maģistra darba tēma ir „Apmācības iespējas Valsts Probācijas dienestā darbiniekiem un ieteikumi tās uzlabošanai.” Darba mērķis ir Valsts Probācijas dienesta darbinieku apmācības iespējas izpēte un noteikt iespējas tās pilnveidošanas iespējas. Maģistra darbs sastāv no četrām nodaļām. Pirmajā nodaļā ir apskatīts apmācības jēdziens un būtība, apmācības veidi un metodes. Otrajā nodaļā ir aprakstīts personāla apmācības kvalitātes un efektivitātes novērtēšana, apmācības efektivitātes novērtēšan...

  12. ASSURE-CSU : A real-world study of burden of disease in patients with symptomatic chronic spontaneous urticaria

    NARCIS (Netherlands)

    Weller, Karsten; Maurer, Marcus; Grattan, Clive; Nakonechna, Alla; Abuzakouk, Mohamed; Bérard, Frédéric; Sussman, Gordon; Giménez-Arnau, Ana M.; Ortiz De Frutos, Javier; Knulst, André; Canonica, G. Walter; Hollis, Kelly; McBride, Doreen; Balp, Maria Magdalena

    2015-01-01

    BACKGROUND: Chronic spontaneous urticaria (CSU) formerly known as chronic idiopathic urticaria (CIU) is a severe and distressing skin condition that remains uncontrolled in approximately one half of patients, despite the use of licensed, recommended doses of modern, second-generation H1-antihistamin

  13. The California State University Louis Stokes Alliance for Minority Participation (CSU-LSAMP): A Collaborative, Comprehensive Approach to Broadening Participation in STEM.

    Science.gov (United States)

    Hammersley, L. C.

    2016-12-01

    The National Science Foundation's Louis Stokes Alliances for Minority Participation (LSAMP) program supports alliances of institutions in their efforts to broaden participation in STEM and diversify the STEM workforce. There are currently 42 LSAMP alliances across the nation. Formed in 1993, the California State University LSAMP program (CSU-LSAMP) is an alliance of all 23 campuses of the CSU system and serves over 3,000 students per year. The primary goals of CSU-LSAMP are to increase persistence and graduation rates for URM participants, increase the number of STEM degrees awarded by the CSU to URM students, and increase the number of CSU-LSAMP students who advance to STEM graduate study. CSU-LSAMP activities are focused on four objectives - academic support (e.g. supplemental instruction & peer mentoring), support at transition points (e.g. first time freshmen & transfer students), research experiences (including international research experiences), and professional development (e.g. conference presentations & graduate school preparation activities). Financial support is offered in the form of textbook assistance, research stipends, and travel awards. We maintain a structure that allows campuses to tailor their programs to meet the needs of their own student populations but that also ties the Alliance together with a set of common activities, goals and policies. External evaluation of the program shows that our approach has been highly successful and can provide useful lessons for other programs focused on broadening participation. Since 1994, the number of URM students enrolled in STEM disciplines at CSU campuses has more than doubled and the number of STEM degrees to URM students has almost tripled. Persistence and graduation rates for URM students who participate in CSU-LSAMP are almost twice those of URM non-participants and equal to those of non-URM students. Of the students who participated in the past 15 years, 42 percent either earned a post

  14. Divas informatīvās telpas Latvijas presē valsts nacionālo svētku diskursā ("Diena", "Neatkarīgā Rīta Avīze", "Čas", "Telegraf" 2006., 2007.g.)

    OpenAIRE

    Pastare, Laila

    2008-01-01

    Bakalaura darbā „Divas informatīvās telpas Latvijas presē valsts nacionālo svētku diskursā. („Diena”, „Neatkarīgā Rīta Avīze”, „Čas”, „Telegraf” 2006.; 2007. g.)” tiek pētīts, kādas atšķirības pastāv starp divām informatīvajām telpām valsts nacionālo svētku diskursā un kā tās izpaužas. Bakalaura darba teorētiskā bāze balstās uz jau esošajiem Ilzes Šulmanes un Sergeja Kruka konceptiem par atšķirīgajām latviešu un krievu informatīvajām telpām, un šo pašu autoru iegūtajiem rezultātiem un sec...

  15. Sabiedrisko attiecību stratēģiskās plānošanas kompetence tiešās valsts pārvaldes iestāžu komunikācijas struktūrvienībās (2006-2007)

    OpenAIRE

    Helmane, Dace

    2007-01-01

    Maģistra darba tēma ir „Sabiedrisko attiecību stratēģiskās plānošanas kompetence tiešās valsts pārvaldes iestāžu komunikācijas struktūrvienībās (2006-2007)”, un tā tika izvēlēta, jo Latvijā līdz šim nav pētīta sabiedrisko attiecību stratēģiskā plānošana un tai nepieciešamās zināšanas un prasmes. Maģistra darba mērķis ir sniegt ieskatu sabiedrisko attiecību stratēģiskajā plānošanā Latvijas tiešās valsts pārvaldes iestādēs un noskaidrot šo iestāžu komunikācijas struktūrvienību vispārējo komp...

  16. A Report Card on Latina/o Leadership in California's Public Universities: A Trend Analysis of Faculty, Students, and Executives in the CSU and UC Systems

    Science.gov (United States)

    Santos, Jose L.; Acevedo-Gil, Nancy

    2013-01-01

    The article examines the status of leadership in two California public higher education systems: California State University (CSU) and the University of California (UC) from 2001 to 2009. Findings reveal that the representation of Latina/o faculty and administrators does not reflect the density in the Latina/o undergraduate student and general…

  17. Assessment, design and control strategy development of a fuel cell hybrid electric vehicle for CSU's EcoCAR

    Science.gov (United States)

    Fox, Matthew D.

    Advanced automotive technology assessment and powertrain design are increasingly performed through modeling, simulation, and optimization. But technology assessments usually target many competing criteria making any individual optimization challenging and arbitrary. Further, independent design simulations and optimizations take considerable time to execute, and design constraints and objectives change throughout the design process. Changes in design considerations usually require re-processing of simulations and more time. In this thesis, these challenges are confronted through CSU's participation in the EcoCAR2 hybrid vehicle design competition. The complexity of the competition's design objectives leveraged development of a decision support system tool to aid in multi-criteria decision making across technologies and to perform powertrain optimization. To make the decision support system interactive, and bypass the problem of long simulation times, a new approach was taken. The result of this research is CSU's architecture selection and component sizing, which optimizes a composite objective function representing the competition score. The selected architecture is an electric vehicle with an onboard range extending hydrogen fuel cell system. The vehicle has a 145kW traction motor, 18.9kWh of lithium ion battery, a 15kW fuel cell system, and 5kg of hydrogen storage capacity. Finally, a control strategy was developed that improves the vehicles performance throughout the driving range under variable driving conditions. In conclusion, the design process used in this research is reviewed and evaluated against other common design methodologies. I conclude, through the highlighted case studies, that the approach is more comprehensive than other popular design methodologies and is likely to lead to a higher quality product. The upfront modeling work and decision support system formulation will pay off in superior and timely knowledge transfer and more informed design

  18. Adsorption Mechanism of Collector CSU-Y on Surface of Calcium Molybdate%捕收剂CSU-Y在钼酸钙表面的吸附机理研究

    Institute of Scientific and Technical Information of China (English)

    刘建东; 王振; 刘润清; 孙伟; 胡岳华

    2015-01-01

    To avoid problems such as low recovery, resource loss and environmental pollution generated during the flotation of calcium molybdate in Ni-Mo ore, open-circuit and closed-circuit tests were carried out to treat flotation tailings of sulfide minerals based on the mineralogical analysis, and a flotation process for oxidized molybdenum ore was proposed while the method of molecular dynamics simulation was introduced to study the absorption behavior of the collector on calcium molybdate and pyrite. The results show that, the primary molybdenum mineral in sulfide mineral flotation tailings is calcium molybdate, while the main gangues are fluorapatite and pyrite. The closed-circuit flotation test resulted in a concentrate grading 3.24% Mo and 3.37% Ni with corresponding recoveries of 69.15% and 62.44%. Collector CSU-Y can be easily absorbed on (111) surface of calcium molybdate, while hardly on (010) plane of apatite and (110) plane of pyrite, through which an efficient flotation separation of calcium molybdate and gangues in tailings can be attained.%针对镍钼矿中钼酸钙浮选回收率低、丢弃造成资源浪费和环境污染等问题,在工艺矿物学研究基础上,对镍钼矿中硫化矿物浮选尾矿进行了开路实验和闭路实验,设计了氧化钼浮选流程,并利用分子动力学模拟研究了捕收剂分子在矿物解离面的吸附过程,结果表明:镍钼矿中硫化矿物浮选尾矿主要含钼矿物为钼酸钙,脉石矿物主要为氟磷灰石和黄铁矿;通过闭路浮选试验得到了Mo品位3.24%、Ni品位3.37%、Mo回收率69.15%、Ni回收率62.44%的精矿;捕收剂油酸分子在钼酸钙(111)面吸附强于氟磷灰石(010)面和黄铁矿( 110)面,从而实现了浮选过程中钼酸钙和脉石矿物的分离,说明捕收剂CSU-Y可浮选分离钼酸钙和脉石矿物.

  19. Accurate Characterization of Winter Precipitation Using In-Situ Instrumentation, CSU-CHILL Radar, and Advanced Scattering Methods

    Science.gov (United States)

    Newman, A. J.; Notaros, B. M.; Bringi, V. N.; Kleinkort, C.; Huang, G. J.; Kennedy, P.; Thurai, M.

    2015-12-01

    We present a novel approach to remote sensing and characterization of winter precipitation and modeling of radar observables through a synergistic use of advanced in-situ instrumentation for microphysical and geometrical measurements of ice and snow particles, image processing methodology to reconstruct complex particle three-dimensional (3D) shapes, computational electromagnetics to analyze realistic precipitation scattering, and state-of-the-art polarimetric radar. Our in-situ measurement site at the Easton Valley View Airport, La Salle, Colorado, shown in the figure, consists of two advanced optical imaging disdrometers within a 2/3-scaled double fence intercomparison reference wind shield, and also includes PLUVIO snow measuring gauge, VAISALA weather station, and collocated NCAR GPS advanced upper-air system sounding system. Our primary radar is the CSU-CHILL radar, with a dual-offset Gregorian antenna featuring very high polarization purity and excellent side-lobe performance in any plane, and the in-situ instrumentation site being very conveniently located at a range of 12.92 km from the radar. A multi-angle snowflake camera (MASC) is used to capture multiple different high-resolution views of an ice particle in free-fall, along with its fall speed. We apply a visual hull geometrical method for reconstruction of 3D shapes of particles based on the images collected by the MASC, and convert these shapes into models for computational electromagnetic scattering analysis, using a higher order method of moments. A two-dimensional video disdrometer (2DVD), collocated with the MASC, provides 2D contours of a hydrometeor, along with the fall speed and other important parameters. We use the fall speed from the MASC and the 2DVD, along with state parameters measured at the Easton site, to estimate the particle mass (Böhm's method), and then the dielectric constant of particles, based on a Maxwell-Garnet formula. By calculation of the "particle-by-particle" scattering

  20. Siting of nuclear power plants in accordance with the scenario of a ''fossil nuclear energy mix'' prepared by the CDU/CSU and FDP in the inquiry commission of the Bundestag on ''Sustainable energy supply in times of globalisation and deregulation''. Short study; Standortbestimmung fuer Kernkraftwerke gemaess dem von CDU/CSU und FDP definierten Szenario 'fossil-nuklearer Energiemix' der Enquete-Kommission 'Nachhaltige Energieversorgung unter den Bedingungen der Globalisierung und der Liberalisierung' des Deutschen Bundestages. Kurzstudie

    Energy Technology Data Exchange (ETDEWEB)

    Benik, G.; Gundelach, T.

    2002-08-28

    In effect the present study makes concrete proposals for the installation of a nuclear power plant capacity of 91.8 GW as determined by the CDU/CSU and FDP in the inquiry commission on ''Sustainable development''. Because of the infrastructural requirements and the large number of plants that would have to be planned in Germany alone these siting proposals must be regarded as an outline for the implementation of a nuclear climate protection strategy. Without extensive assessment work a short study such as this cannot of course replace the detailed planning that would be required for authorisation procedures. The primary benefit of the study is that it makes clear the true consequences of a nuclear climate protection policy that is now being discussed as a hypothetical possibility. [German] Die vorliegende Studie macht im Ergebnis entsprechend der Aufgabenstellung konkrete Vorschlaege fuer die Bereitstellung der im von CDU/CSU und FDP in der Enquete-Kommission ''Nachhaltige Entwicklung'' definierten Szenario ''Fossilnuklearer Energiemix'' ermittelten nuklearen Kraftwerksleistung von 91,8 GW Diese Standortvorschlaege muessen angesichts der infrastrukturellen Anforderungen und der grossen Zahl von zu planenden Anlagen allein innerhalb der Grenzen der Bundesrepublik Deutschland als Anhaltspunkte fuer die Umsetzung einer nuklearen Klimaschutzstrategie herangezogen werden. Dabei kann eine Kurzstudie selbstverstaendlich ohne umfaengliche Pruefung keine detaillierten Planungen ersetzen, welche im Rahmen entsprechender Genehmigungsverfahren erforderlich sind. Der Nutzen der Studie besteht in erster Linie darin, deutlich vor Augen zu fuehren, welche realen Konsequenzen eine zur Zeit noch hypothetisch gefuehrte Diskussion ueber den Einsatz der Kernkraft zum Klimaschutz hat. (orig.)

  1. Krimināltiesības Seno austrumu valstīs - Divupe, Indija

    OpenAIRE

    Svirkovskis, Viktors

    2009-01-01

    The Bachelor‘s Paper “The Criminal rights in the Ancient east – Mesopotamia, India” is divided into 3 chapters. In the first chapter named “The rights in archaic society” the rights are looked in historical period before the state was established, when society goes throw the two stages of development – the stage of gathering economy, and the stage of productive economy, when the key role of social regulation played manners. The second chapter “Social structure and conception of the pun...

  2. CSU solar house II, Fort Collins, Colorado, USA

    Energy Technology Data Exchange (ETDEWEB)

    Loef, G.

    1999-07-01

    This middle-sized single-family house, with its type 1 solar air system, has been in operation for almost a quarter of a century. The system consists of factory-built collectors, site-built rock-bed heat storage, an electric heat-pump for auxiliary heating and fully automatic temperature controls. Extensive measuring and testing facilities were provided for continuous monitoring of all energy sources and uses. The solar air system meets about three quarters of the annual heat requirements of the building. (author)

  3. CSU's MWV Observatory: A Facility for Research, Education and Outreach

    Science.gov (United States)

    Hood, John; Carpenter, N. D.; McCarty, C. B.; Samford, J. H.; Johnson, M.; Puckett, A. W.; Williams, R. N.; Cruzen, S. T.

    2014-01-01

    The Mead Westvaco Observatory (MWVO), located in Columbus State University's Coca-Cola Space Science Center, is dedicated to education and research in astronomy through hands-on engagement and public participation. The MWVO has recently received funding to upgrade from a 16-inch Meade LX-200 telescope to a PlaneWave CDK 24-inch Corrected Dall-Kirkham Astrograph telescope. This and other technological upgrades will allow this observatory to stream live webcasts for astronomical events, allowing a worldwide public audience to become a part of the growing astronomical community. This poster will explain the upgrades that are currently in progress as well as the results from the current calibrations. The goal of these upgrades is to provide facilities capable of both research-class projects and widespread use in education and public outreach. We will present our initial calibration and tests of the observatory equipment, as well as its use in webcasts of astronomical events, in solar observing through the use of specialized piggy-backed telescopes, and in research into such topics as asteroids, planetary and nebula imaging. We will describe a pilot research project on asteroid orbit refinement and light curves, to be carried out by Columbus State University students. We will also outline many of the K-12 educational and public outreach activities we have designed for these facilities. Support and funding for the acquisition and installation of the new PlaneWave CDK 24 has been provided by the International Museum and Library Services via the Museums for America Award.

  4. CSU Standard for the CLSI Expanded Title Record.

    Science.gov (United States)

    Anderson, Karen; And Others

    The revised system specifications described in this document were adopted by the 19 California State University and College (CSUC) libraries for a second test version of the CLSI "Expanded Title Record" public access online catalog at California State University at Chico. Should this pilot demonstration of the data format prove…

  5. Squeezed from All Sides: The CSU Crisis and California's Future

    Science.gov (United States)

    Civil Rights Project / Proyecto Derechos Civiles, 2011

    2011-01-01

    California long enjoyed rapid growth, abundant jobs, and expanding college opportunity--key elements of the California dream. Now the state is struggling to recover from its worst economic crisis in generations, a demographic slowdown, a devastating collapse of the wealth of the state' families from the housing crisis, and severe cutbacks in…

  6. CSU Standard for the CLSI Expanded Title Record.

    Science.gov (United States)

    Anderson, Karen; And Others

    The revised system specifications described in this document were adopted by the 19 California State University and College (CSUC) libraries for a second test version of the CLSI "Expanded Title Record" public access online catalog at California State University at Chico. Should this pilot demonstration of the data format prove…

  7. Administratīvie akti, kas izdoti, pildot deleģētos valsts pārvaldes uzdevumus

    OpenAIRE

    Kajaks, Jānis

    2015-01-01

    Darbā autors noskaidro administartīvo aktu izdošanas deleģējuma tiesisko regulējumu, noskaidro, vai administratīvo aktu izdošana tiek deleģēta atbilstoši tiesiskajam regulējumam, kā arī noskaidro, kas ir atbildētājs tiesā administratīvajiem aktiem, kuru izdošana ir deleģēta. Darba mērķis: izpētīt administratīvos aktus, kuru izdošana ir deleģēta. Pētījuma rezultātā noskaidrots, ka ne vienmēr administratīvo aktu izdošana tiek deleģēta atbilstoši tiesiskajam regulējumam, bet atbildētājs ti...

  8. Financing College in Hard Times: Work and Student Aid. The CSU Crisis and California's Future

    Science.gov (United States)

    Civil Rights Project / Proyecto Derechos Civiles, 2011

    2011-01-01

    This report is the third in a series of reports designed to analyze the impact of the fiscal cutbacks on opportunity for higher education in the California State University system, the huge network of 23 universities that provide the greatest amount of Bachelor of Arts (BA) level of education in the state. The first study, "Higher Tuition,…

  9. Writing for Chemists: Satisfying the CSU Upper-Division Writing Requirement

    Science.gov (United States)

    Paulson, Donald R.

    2001-08-01

    This paper describes Chemistry 360, Writing for Chemists, which is a junior-level course required of all Chemistry and Biochemistry majors at California State University, Los Angeles. The course covers all of the sections for writing both primary and secondary papers in the chemical sciences as well as the process of literature searching in both computer databases and the printed Chemical Abstracts. The course is team taught by several chemistry faculty members and an English faculty member. The core of the course is a review paper on an individually assigned topic in chemistry or biochemistry. The students are given daily writing assignments that teach them how to write the various sections of the paper. They also learn how to write both Experimental and Results sections, which are not part of a review paper. In addition the course deals with ethics in science, how to give an oral presentation, and how to prepare a poster presentation.

  10. Monitoring Based Commissioning: Benchmarking Analysis of 24 UC/CSU/IOU Projects

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Evan; Mathew, Paul

    2009-04-01

    Buildings rarely perform as intended, resulting in energy use that is higher than anticipated. Building commissioning has emerged as a strategy for remedying this problem in non-residential buildings. Complementing traditional hardware-based energy savings strategies, commissioning is a 'soft' process of verifying performance and design intent and correcting deficiencies. Through an evaluation of a series of field projects, this report explores the efficacy of an emerging refinement of this practice, known as monitoring-based commissioning (MBCx). MBCx can also be thought of as monitoring-enhanced building operation that incorporates three components: (1) Permanent energy information systems (EIS) and diagnostic tools at the whole-building and sub-system level; (2) Retro-commissioning based on the information from these tools and savings accounting emphasizing measurement as opposed to estimation or assumptions; and (3) On-going commissioning to ensure efficient building operations and measurement-based savings accounting. MBCx is thus a measurement-based paradigm which affords improved risk-management by identifying problems and opportunities that are missed with periodic commissioning. The analysis presented in this report is based on in-depth benchmarking of a portfolio of MBCx energy savings for 24 buildings located throughout the University of California and California State University systems. In the course of the analysis, we developed a quality-control/quality-assurance process for gathering and evaluating raw data from project sites and then selected a number of metrics to use for project benchmarking and evaluation, including appropriate normalizations for weather and climate, accounting for variations in central plant performance, and consideration of differences in building types. We performed a cost-benefit analysis of the resulting dataset, and provided comparisons to projects from a larger commissioning 'Meta-analysis' database. A total of 1120 deficiency-intervention combinations were identified in the course of commissioning the projects described in this report. The most common location of deficiencies was in HVAC equipment (65% of sites), followed by air-handling and distributions systems (59%), cooling plant (29%), heating plants (24%), and terminal units (24%). The most common interventions were adjusting setpoints, modifying sequences of operations, calibration, and various mechanical fixes (each done in about two-thirds of the sites). The normalized rate of occurrence of deficiencies and corresponding interventions ranged from about 0.1/100ksf to 10/100ksf, depending on the issue. From these interventions flowed significant and highly cost-effective energy savings For the MBCx cohort, source energy savings of 22 kBTU/sf-year (10%) were achieved, with a range of 2% to 25%. Median electricity savings were 1.9 kWh/sf-year (9%), with a range of 1% to 17%. Peak electrical demand savings were 0.2 W/sf-year (4%), with a range of 3% to 11%. The aggregate commissioning cost for the 24 projects was $2.9 million. We observed a range of normalized costs from $0.37 to 1.62/sf, with a median value of $1.00/sf for buildings that implemented MBCx projects. Per the program design, monitoring costs as a percentage of total costs are significantly higher in MBCx projects (median value 40%) than typical commissioning projects included in the Meta-analysis (median value of 2% in the commissioning database). Half of the projects were in buildings containing complex and energy-intensive laboratory space, with higher associated costs. Median energy cost savings were $0.25/sf-year, for a median simple payback time of 2.5 years. Significant and cost-effective energy savings were thus obtained. The greatest absolute energy savings and shortest payback times were achieved in laboratory-type facilities. While impacts varied from project to project, on a portfolio basis we find MBCx to be a highly cost-effective means of obtaining significant program-level energy savings across a variety of building types. Energy savings are expected to be more robust and persistent for MBCx projects than for conventionally commissioned ones. Impacts of future programs can be maximized by benchmarking energy use and targeting the commissioning towards particularly energy-intensive facilities such as laboratories.

  11. Numerical simulation of tropical-temperate troughs over Southern Africa using the CSU RAMS model

    CSIR Research Space (South Africa)

    Van den Heever, SC

    1997-08-01

    Full Text Available ) and the wet (1981) late summer case studies has been examined. Model simulations reveal that the tropical-temperate troughs form when an upper westerly wave coincides with an easterly, wave or depression in lower levels. These systems occur preferentially over...

  12. Two Studies of a Faculty in Crisis: The CSU Crisis and California's Future

    Science.gov (United States)

    Civil Rights Project / Proyecto Derechos Civiles, 2011

    2011-01-01

    The fundamental asset of a university is its faculty. Without faculty working with students, the university is just a set of buildings. The faculty design and teach the courses, keep the educational program updated, and work with students to help them gain the skills and knowledge they need to prepare for their careers or professional education.…

  13. Saksa Bundestag'i väliskomisjoni CDU/CSU grupi esindaja hr. Andreas Schokenhoffi ettekanne / Andreas Schokenhoff

    Index Scriptorium Estoniae

    Schokenhoff, Andreas

    2002-01-01

    Ilmunud ka: Proceedings of the 8th International conference Estonia and the European Union : Estonia on its way to a changing Europe : October 31-November 2, 2001. - Tallinn, lk., lk. 91-93. Euroopa julgeoleku- ja kaitsepoliitika vallas on kolme liiki vastutust: ennetav, tsiviilkriiside lahendamine ja sõjaline sekkumine

  14. Saksa Bundestag'i väliskomisjoni CDU/CSU grupi esindaja hr. Andreas Schokenhoffi ettekanne / Andreas Schokenhoff

    Index Scriptorium Estoniae

    Schokenhoff, Andreas

    2002-01-01

    Ilmunud ka: Proceedings of the 8th International conference Estonia and the European Union : Estonia on its way to a changing Europe : October 31-November 2, 2001. - Tallinn, lk., lk. 91-93. Euroopa julgeoleku- ja kaitsepoliitika vallas on kolme liiki vastutust: ennetav, tsiviilkriiside lahendamine ja sõjaline sekkumine

  15. Liquid and Ice Cloud Microphysics in the CSU General Circulation Model. Part III: Sensitivity to Modeling Assumptions.

    Science.gov (United States)

    Fowler, Laura D.; Randall, David A.

    1996-03-01

    The inclusion of cloud microphysical processes in general circulation models makes it possible to study the multiple interactions among clouds, the hydrological cycle, and radiation. The gaps between the temporal and spatial scales at which such cloud microphysical processes work and those at which general circulation models presently function force climate modelers to crudely parameterize and simplify the various interactions among the different water species (namely, water vapor, cloud water, cloud ice, rain, and snow) and to use adjustable parameters to which large-scale models can be highly sensitive. Accordingly, the authors have investigated the sensitivity of the climate, simulated with the Colorado State University general circulation model, to various aspects of the parameterization of cloud microphysical processes and its interactions with the cumulus convection and radiative transfer parameterizations.The results of 120-day sensitivity experiments corresponding to perpetual January conditions have been compared with those of a control simulation in order to 1 ) determine the importance of advecting cloud water, cloud ice, rain, and snow at the temporal and spatial scale resolutions presently used in the model; 2) study the importance of the formation of extended stratiform anvils at the tops of cumulus towers, 3) analyze the role of mixed-phase clouds in determining the partitioning among cloud water, cloud ice, rain, and snow and, hence, their impacts on the simulated cloud optical properties; 4) evaluate the sensitivity of the atmospheric moisture budget and precipitation rates to a change in the fall velocities of rain and snow; 5) determine the model's sensitivity to the prescribed thresholds of autoconversion of cloud water to rain and cloud ice to snow; and 6) study the impact of the collection of supercooled cloud water by snow, as well as accounting for the cloud optical properties of snow.Results are presented in terms of 30-day mean differences between the sensitivity experiments and control run. The authors find that three-dimensional advection of the water species has little influence on their geographical distributions and globally averaged amounts. The simulated climate remains unchanged when detrained condensed water at the tops of cumulus towers is used as a source of rain and snow rather than as a source of cloud water and cloud ice. In contrast, instantaneously removing cloud water and cloud ice detrained at the tops of cumulus towers in the form of precipitation yields a strong drying of the atmosphere and a significant reduction in the size of the anvils. Altering the partitioning between cloud ice and supercooled cloud water produces significant changes in the vertical distributions of the cloud optical depth and effective cloud fraction, hence producing significant variations in the top-of-the-atmosphere longwave and shortwave cloud radiative forcings. Increasing the fall speeds of rain and snow leads to a decrease in cloudiness and an increase in stratiform rainfall. Increasing the thresholds for autoconversion of cloud water to rain and cloud ice to snow yields a significant increase in middle- and high-level clouds and a reduction of the cumulus precipitation rate. The collection of supercooled cloud water by snow appeared to be an important microphysical process for mixed-phase clouds. Finally, the optical effects of snow have little impact upon the top-of-the-atmosphere radiation budget.This study illustrates the need for in-depth analysis of the spatial and temporal scale dependence of the different microphysical parameters of the cloud parameterizations used in general circulation models.

  16. Hashimoto's disease is a frequent comorbidity and an exacerbating factor of chronic spontaneous urticaria

    National Research Council Canada - National Science Library

    Sugiyama, A; Nishie, H; Takeuchi, S; Yoshinari, M; Furue, M

    2015-01-01

    The precise pathogenesis of chronic spontaneous urticaria (CSU) remains unknown. However, an important association between CSU and autoimmune disorders such as Hashimoto's disease (HD) has been reported...

  17. CSU Final Report on the Math/CS Institute CACHE: Communication-Avoiding and Communication-Hiding at the Extreme Scale

    Energy Technology Data Exchange (ETDEWEB)

    Strout, Michelle [Colorado State University

    2014-06-10

    The CACHE project entails researching and developing new versions of numerical algorithms that result in data reuse that can be scheduled in a communication avoiding way. Since memory accesses take more time than any computation and require the most power, the focus on turning data reuse into data locality is critical to improving performance and reducing power usage in scientific simulations. This final report summarizes the accomplishments at Colorado State University as part of the CACHE project.

  18. Effector Cells and Mechanisms in Chronic Spontaneous Urticaria

    OpenAIRE

    Borzova, Elena

    2014-01-01

    Background: Chronic spontaneous urticaria (CSU) is characterised by weals, angioedema, or both, which occur for six weeks or more. Itchy, red and raised weals in CSU are thought to occur as a result of skin mast cell activation, local vasodilatation and increased vascular permeability which are the cardinal features of the disease. Serum histamine-releasing activity and abnormal basophil function were implicated in the pathophysiology of CSU. We hypothesized that severe and/or persistent CSU ...

  19. Hashimoto's disease is a frequent comorbidity and an exacerbating factor of chronic spontaneous urticaria.

    Science.gov (United States)

    Sugiyama, A; Nishie, H; Takeuchi, S; Yoshinari, M; Furue, M

    2015-01-01

    The precise pathogenesis of chronic spontaneous urticaria (CSU) remains unknown. However, an important association between CSU and autoimmune disorders such as Hashimoto's disease (HD) has been reported. We investigated the frequency of HD as a comorbidity of CSU and the prevalence rate of autoreactivity among CSU patients with HD. The presence of thyroid autoantibodies and the levels of thyroid hormones were examined in 40 CSU patients who showed urticaria symptoms for >4 weeks. Patients who were diagnosed with HD, including subclinical ones, and were in need of treatment received thyroid therapy, and the changes in their urticarial symptoms were observed. An autologous serum skin test (ASST) was also performed to examine the relation of CSU with autoreactivity. Eleven of the 40 CSU patients were diagnosed with HD, and 4 of the 5 patients who received and completed thyroid therapy showed considerable remission of urticarial symptoms during and after treatment. In addition, the rate of positive ASST results tended to be higher in CSU patients with HD (5 of 7) than in those without HD (2 of 6). The comorbidity rate of HD in CSU patients was high, and such patients tended to have a positive ASST. Thyroid therapy in CSU patients with HD can lead to a considerable remission of urticarial symptoms, which may suggest that HD is possibly involved in the aetiology of CSU, or is at least a potential exacerbating factor for CSU. Copyright © 2013 SEICAP. Published by Elsevier Espana. All rights reserved.

  20. Implementing an Open Source Learning Management System: A Critical Analysis of Change Strategies

    Science.gov (United States)

    Uys, Philip M.

    2010-01-01

    This paper analyses the change and innovation strategies that Charles Sturt University (CSU) used from 2007 to 2009 during the implementation and mainstreaming of an open source learning management system (LMS), Sakai, named locally as "CSU Interact". CSU was in January 2008 the first Australian University to implement an open source…

  1. 78 FR 72706 - Notice of Inventory Completion: Colorado State University, Fort Collins, CO

    Science.gov (United States)

    2013-12-03

    ... funerary objects should submit a written request to CSU Department of Anthropology. If no additional... request with information in support of the request to the Department of Anthropology at CSU at the address... of the human remains were removed from CSU during a social protest by individuals presumably...

  2. Implementing an Open Source Learning Management System: A Critical Analysis of Change Strategies

    Science.gov (United States)

    Uys, Philip M.

    2010-01-01

    This paper analyses the change and innovation strategies that Charles Sturt University (CSU) used from 2007 to 2009 during the implementation and mainstreaming of an open source learning management system (LMS), Sakai, named locally as "CSU Interact". CSU was in January 2008 the first Australian University to implement an open source…

  3. Determination of contact maps in proteins: A combination of structural and chemical approaches

    Energy Technology Data Exchange (ETDEWEB)

    Wołek, Karol; Cieplak, Marek, E-mail: mc@ifpan.edu.pl [Institute of Physics, Polish Academy of Science, Al. Lotników 32/46, 02-668 Warsaw (Poland); Gómez-Sicilia, Àngel [Instituto Cajal, Consejo Superior de Investigaciones Cientificas (CSIC), Av. Doctor Arce, 37, 28002 Madrid (Spain); Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), C/Faraday 9, 28049 Cantoblanco (Madrid) (Spain)

    2015-12-28

    Contact map selection is a crucial step in structure-based molecular dynamics modelling of proteins. The map can be determined in many different ways. We focus on the methods in which residues are represented as clusters of effective spheres. One contact map, denoted as overlap (OV), is based on the overlap of such spheres. Another contact map, named Contacts of Structural Units (CSU), involves the geometry in a different way and, in addition, brings chemical considerations into account. We develop a variant of the CSU approach in which we also incorporate Coulombic effects such as formation of the ionic bridges and destabilization of possible links through repulsion. In this way, the most essential and well defined contacts are identified. The resulting residue-residue contact map, dubbed repulsive CSU (rCSU), is more sound in its physico-chemical justification than CSU. It also provides a clear prescription for validity of an inter-residual contact: the number of attractive atomic contacts should be larger than the number of repulsive ones — a feature that is not present in CSU. However, both of these maps do not correlate well with the experimental data on protein stretching. Thus, we propose to use rCSU together with the OV map. We find that the combined map, denoted as OV+rCSU, performs better than OV. In most situations, OV and OV+rCSU yield comparable folding properties but for some proteins rCSU provides contacts which improve folding in a substantial way. We discuss the likely residue-specificity of the rCSU contacts. Finally, we make comparisons to the recently proposed shadow contact map, which is derived from different principles.

  4. Nekustamā īpašuma tirgus attīstība un dinamika, un iespējamās izmaiņas paaugstinātas inflācijas apstākļos

    OpenAIRE

    Bogdanova, Elenora

    2008-01-01

    Maģistra darbs „Nekustamā īpašuma tirgus attīstība un dinamika un iespējamās izmaiņas paaugstinātas inflācijas apstākļos”. Darba mērķis ir, izanalizējot Latvijas nekustamā īpašuma tirgus attīstības tendences, noteikt tā stāvokli paaugstinātas inflācijas apstākļos. Nekustamā īpašuma tirgus ir viens no valsts ekonomikas stūrakmeņiem, kas nosaka valsts ekonomiku ietekmējošo faktoru stāvokli. Runājot par nekustamo īpašumu tirgu, vispirms autors noskaidro, kas ir tirgus, nekustamais tirgus un ...

  5. An Innovative International Program for the Preparation of Bilingual-Crosscultural Teachers.

    Science.gov (United States)

    Tarrow, Norma; Sutter, Richard

    Searching for additional bilingual-crosscultural teachers, the California State University (CSU) system plans to combine teacher education and the CSU International Programs approach. Basic elements of this program are: (1) intensive study of Spanish and immersion in a Spanish-speaking milieu; (2) a living experience in the Mexican culture; (3) a…

  6. Genome-wide analysis of esterase-like genes in the striped rice stem borer, Chilo suppressalis.

    Science.gov (United States)

    Wang, Baoju; Wang, Ying; Zhang, Yang; Han, Ping; Li, Fei; Han, Zhaojun

    2015-06-01

    The striped rice stem borer, Chilo suppressalis, a destructive pest of rice, has developed high levels of resistance to certain insecticides. Esterases are reported to be involved in insecticide resistance in several insects. Therefore, this study systematically analyzed esterase-like genes in C. suppressalis. Fifty-one esterase-like genes were identified in the draft genomic sequences of the species, and 20 cDNA sequences were derived which encoded full- or nearly full-length proteins. The putative esterase proteins derived from these full-length genes are overall highly diversified. However, key residues that are functionally important including the serine residue in the active site are conserved in 18 out of the 20 proteins. Phylogenetic analysis revealed that most of these genes have homologues in other lepidoptera insects. Genes CsuEst6, CsuEst10, CsuEst11, and CsuEst51 were induced by the insecticide triazophos, and genes CsuEst9, CsuEst11, CsuEst14, and CsuEst51 were induced by the insecticide chlorantraniliprole. Our results provide a foundation for future studies of insecticide resistance in C. suppressalis and for comparative research with esterase genes from other insect species.

  7. Cooperative Institute for Research in the Atmosphere (CIRA) Requirements Review

    Energy Technology Data Exchange (ETDEWEB)

    Zurawski, Jason, W; Mace, Kathryn, P

    2016-08-11

    In August 2016 The Energy Sciences Network (ESnet) and Colorado State University (CSU) organized a review to characterize the networking requirements of the Cooperative Institute for Research in the Atmosphere (CIRA) located on the campus of Colorado State University. Several key findings highlighting the results from the review were discovered, with benefits to improve the overall scientific process for CIRA and CSU.

  8. Occasional Papers in Open and Distance Learning, Number 21.

    Science.gov (United States)

    Donnan, Peter, Ed.

    This document contains two papers that deal with the shifts in learning and teaching at Charles Sturt University (CSU), Australia. The first paper, "Inaugural CELT Learning and Teaching Forum: Re-Examining Learning and Teaching at CSU, Outcomes and Further Actions," contains the outcomes and further actions arising from the inaugural CELT (Centre…

  9. The Effect of Mandatory Furloughs on Self-Determination, Financial Strain, and Decision to Leave the California State University System in Social Work Faculty

    Science.gov (United States)

    Hohman, Melinda; Packard, Thomas; Finnegan, Daniel; Jones, Loring

    2013-01-01

    In uncertain economic times, universities have taken steps to address financial problems by including the use of business models. In 2009, the California State University (CSU) system implemented furloughs of a 10% pay reduction and 18 days removed from the academic calendar. Faculty in 16 CSU schools of social work participated in a Web-based…

  10. Analysis of Circulating Vascular Endothelial Growth Factor and Its Soluble Receptors in Patients with Different Forms of Chronic Urticaria

    Directory of Open Access Journals (Sweden)

    Julia Jagodzinska

    2015-01-01

    Full Text Available Background. Vascular endothelial growth factor (VEGF is a powerful enhancer of vascular permeability and inflammatory response; however its significance in chronic urticaria is poorly recognised. Aim. To compare free circulating levels of VEGF and its soluble receptors (sVEGFR1 and VEGFR2 in patients with different forms of chronic urticaria. Methods. The concentrations of VEGF and its receptors in plateletpoor plasma (PPP/plasma were measured using enzyme-linked immunosorbent assay in chronic urticaria: (1 chronic spontaneous urticaria (CSU with positive autologous serum skin test (ASST, (2 CSU with negative response to ASST, (3 CSU with concomitant euthyroid Hashimoto’s thyroiditis (CSU/Hashimoto, (4 delayed pressure urticaria (DPU, and the healthy subjects. Results. There were no significant differences in VEGF concentration in PPP between CSU groups and the healthy subjects. Contrary, VEGF concentration was significantly higher in DPU and CSU/Hashimoto patients as compared with the healthy subjects and CSU groups. Furthermore, VEGF value in CSU/Hashimoto patients during the remission was similar to that of the active period and significantly higher than the healthy subjects; VEGF concentration was significantly correlated with TSH. Plasma concentrations of sVEGF1 and sVEGF2 were similar in chronic urticaria patients and the healthy subjects. Conclusions. Increased free circulating VEGF concentration may result from the urticarial process itself as well as concomitant Hashimoto’s thyroiditis.

  11. Cardiovascular Risk is not Increased in Patients with Chronic Urticaria

    DEFF Research Database (Denmark)

    Egeberg, Alexander; Gislason, Gunnar H; Vestergaard, Christian

    2016-01-01

    Chronic urticaria (CU) is a common condition characterized by daily or almost daily occurrence of wheals, angioedema, or both over a period of more than 6 weeks (1). CU is classified into inducible (CIndU) and spontaneous forms (CSU). The annual period prevalence of CSU was recently estimated...

  12. Cooperative Institute for Research in the Atmosphere (CIRA) Requirements Review

    Energy Technology Data Exchange (ETDEWEB)

    Zurawski, Jason, W; Mace, Kathryn, P

    2016-09-30

    In August 2016 The Energy Sciences Network (ESnet) and Colorado State University (CSU) organized a review to characterize the networking requirements of the Cooperative Institute for Research in the Atmosphere (CIRA) located on the campus of Colorado State University. Several key findings highlighting the results from the review were discovered, with benefits to improve the overall scientific process for CIRA and CSU.

  13. Adverse Reaction to Omalizumab in Patients with Chronic Urticaria: Flare Up or Ineffectiveness?

    Science.gov (United States)

    Ertaş, Ragıp; Özyurt, Kemal; Yıldız, Sinem; Ulaş, Yılmaz; Turasan, Abdullah; Avcı, Atıl

    2016-02-01

    Omalizumab is a recombinant humanized anti-Ig E monoclonal antibody used as the third line treatment of chronic spontaneous urticaria (CSU). We report four patients with severe antihistamine-resistant CSU, who developed angioedema, anaphylaxis and/or flare up of urticaria at different times following omalizumab therapy.

  14. Comparison between the intravenous and caudal routes of sufentanil in children undergoing orchidopexy and further evaluation of the association of caudal adrenaline and neostigmine

    Directory of Open Access Journals (Sweden)

    Gabriela Rocha Lauretti

    2014-01-01

    Full Text Available Background: The aim of this study was to compare the intravenous (IV and caudal routes of administration of sufentanil for children undergoing orchidopexy and also to evaluate the effects on addition of caudal adrenaline and neostigmine. Materials and Methods: Sixty patients scheduled for orchidopexy were divided into the following groups: 1 Group IVSu received IV 0.5 μg/kg sufentanil and caudal saline; 2 Group CSu received caudal 0.5 μg/kg sufentanil and IV saline; 3 Group CSuAdr received caudal sufentanil plus adrenaline 5 μg/ml (1:200,000 and IV saline; 4 Group CSuNeo received caudal sufentanil plus neostigmine, and IV saline; and 5 Group CSuNeoAdr received caudal sufentanil plus neostigmine plus adrenaline, and IV saline. Heart rate and mean blood pressure >15% was treated with increasing isoflurane concentration. Consumption of isoflurane, side effects, quality of sleep, time to first administration of analgesic, and number of doses of 24-h rescue analgesic were recorded. Results: Groups were demographically similar. Isoflurane consumption showed the following association: Group IVSu = Group CSuNeo = Group CSuNeoAdr Group CSuNeo = Group CSuNeoAdr (P < 0.005. Incidence of adverse effects was similar among groups. Conclusion: Caudal sufentanil alone was no better than when administered in the IV route, and would just be justified by the association of neostigmine, but not adrenaline. Neostigmine association resulted in better perioperative analgesia.

  15. 拉脱维亚开始向美国出口松木

    Institute of Scientific and Technical Information of China (English)

    姜锋

    2006-01-01

    美国:关于拉脱维亚产欧洲赤松(Pinus sylvestris)对于美国消费市场的适应性的评估研究已经完成。该项研究由JSC“Latvijas Valsts Meli”资助并遵循该公司的战略计划,其主要目的是增加企业的竞争能力。

  16. CERT tribal internship program. Final intern report: Karen Sandoval, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    The purpose of the project was to: create a working relationship between CERT and Colorado State University (CSU); involve and create relationships among individuals and departments at CSU; empower Native communities to run their own affairs; establish programs for the benefit of Tribes; and create Native American Program Development Office at CSU. The intern lists the following as the project results: revised a Native American Program Development document; confirmation from 45 departments across campus for Summit attendance [Tribal Human Resource Development Summit]; created initial invitee list from CSU departments and colleges; and informed CERT and CSU staff of results. Much of the response from the campus community has been positive and enthusiastic. They are ready to develop new Native American programs on campus, but need the awareness of what they can do to be respectful of Tribal needs.

  17. Omalizumab for treating chronic spontaneous urticaria: an expert review on efficacy and safety.

    Science.gov (United States)

    Giménez-Arnau, Ana M

    2017-03-01

    Chronic spontaneous urticaria (CSU) is characterized by the recurrence of itchy hives and/or angioedema for greater than six weeks, with no known external trigger. Omalizumab, a humanized, recombinant, monoclonal anti-IgE antibody, is the only approved add-on therapy for H1-antihistamine refractory CSU patients. Areas covered: The objective of this article is to discuss the mechanism of action, pharmacokinetics and pharmacodynamics of omalizumab for the treatment of CSU. The review also summarizes efficacy and safety data from proof-of-concept, phase II (X-CUISITE, MYSTIQUE), and pivotal phase III omalizumab studies (ASTERIA I, ASTERIA II, and GLACIAL). Expert opinion: Omalizumab is a clinically effective and safe biological therapy for treating H1-antihistamine refractory CSU patients. It significantly reduces CSU symptoms (hives, itch and angioedema), and improves patient health-related quality of life. While omalizumab is already integral to the treatment of antihistamine refractory CSU, widespread use will depend on legal and economic factors, as well as improvements in the early and accurate diagnosis of CSU patients who would benefit from treatment.

  18. The clinical and laboratory characteristics of acute spontaneous urticaria and its progression to chronic spontaneous urticaria.

    Science.gov (United States)

    Magen, Eli; Zueva, Ekaterina; Mishal, Joseph; Schlesinger, Menachem

    2016-09-01

    The natural history of the progression from acute spontaneous urticaria (ASU) to chronic spontaneous urticaria (CSU), CSU remains poorly understood. To identify clinical and laboratory patient attributes that may be predictive of ASU progression to CSU. We prospectively studied consecutive adult patients (age ≥ 18 years) with a diagnosis of urticaria of urticaria activity score assessment were performed in all the patients at baseline and then at weeks 7, 12, 24, and 48. Of 114 patients with acute urticaria and without identifiable causes, 73 patients (64%) were included in the ASU group, 41 patients in the CSU group (36%), and 44 healthy subjects in the control group. At baseline, 26 patients in the CSU group (63.4%) had a positive ASST result, whereas only 17 patients with a positive ASST result (23.3%) were revealed in the ASU group (p < 0.001). Patients with baseline ASST positive results were characterized by more profound basopenia (mean [standard deviation], 0.05 ± 0.08 cell/mm(3)) and more anti-thyroid peroxidase antibodies (18 [41.8%]) than those with the negative baseline ASST result (mean [standard deviation], 0.13 ± 0.09 cell/mm(3), p < 0.001 more profound basopenia; and 13 (18.1%), p = 0.009 more thyroid peroxidase antibodies). We observed the disappearance of ASST positive result in some patients with CSU with baseline positive ASST results, whereas, in some subjects with CSU, baseline negative ASST results came to be positive results throughout the study period. A baseline positive ASST result of patients with ASU was a significant determinant (odds ratio 5.91 [95% confidence interval, 2.57-13.62]; p < 0.001) for a CSU diagnosis at week 7. The patients with ASU who progressed toward CSU were characterized by a positive ASST result, thyroid autoimmunity, and profound basopenia at baseline.

  19. Upregulated expression of substance P in basophils of the patients with chronic spontaneous urticaria: induction of histamine release and basophil accumulation by substance P.

    Science.gov (United States)

    Zheng, Wenjiao; Wang, Junling; Zhu, Wei; Xu, Chiyan; He, Shaoheng

    2016-06-01

    Human basophils have been implicated in the pathogenesis of chronic spontaneous urticaria (CSU), and substance P (SP) is a possible candidate as histamine-releasing factor in some patients with CSU. However, little is known of relationship between basophils and SP in CSU. In the present study, we investigated expression of SP and NK1R on basophils from patients with CSU, and influence of SP on basophil functions by using flow cytometry analysis, basophil challenge, and mouse sensitization model techniques. The results showed that plasma SP level and basophil numbers in CSU patients were higher than that in HC subject. The percentages of SP+ and NK1R+ basophils were markedly elevated in CSU blood in comparison with HC blood. Once added, SP induced up to 41.2 % net histamine release from basophils of CSU patients, which was comparable with that provoked by anti-IgE, and fMLP. It appeared that SP induced dramatic increase in blood basophil numbers of mice following peritoneal injection. Ovalbumin (OVA)-sensitized mice had much more SP+ and NK1R+ basophils in blood than non-sensitized mice. In conclusion, the elevated plasma concentration of SP, upregulated expression of SP and NK1R on basophils, and the ability of SP in induction of basophil degranulation and accumulation indicate strongly that SP is most likely a potent proinflammatory mediator, which contributes greatly to the pathogenesis of CSU through basophils. Inhibitors of SP and blockers of NK1R are likely useful agents for treatment of CSU.

  20. Chronic spontaneous urticaria and internal parasites--a systematic review.

    Science.gov (United States)

    Kolkhir, P; Balakirski, G; Merk, H F; Olisova, O; Maurer, M

    2016-03-01

    Chronic spontaneous urticaria (CSU) is defined as persistent wheals, angioedema, or both lasting for >6 weeks due to known or unknown causes. Some epidemiological studies and case reports suggest that internal parasite infections (PI) can cause CSU. Here, we provide a systematic overview of published findings on the prevalence and relevance of PI in CSU and we discuss possible pathomechanisms. The prevalence of PI in CSU was investigated by 39 independent studies and comorbidity reportedly ranged from 0 to 75.4% (two-thirds of these studies reported infection rates of 10% or less). The prevalence of PI in adult and pediatric CSU patients ranged from 0% to 75.4% and from 0% to 37.8%, respectively. CSU patients were more often diagnosed with protozoa and had a significantly higher risk of toxocariasis seropositivity and Anisakis simplex sensitization when compared to healthy controls. Patients with chronic urticaria more frequently had seropositivity of fasciolosis, Anisakis simplex sensitization, and the presence of Blastocystis hominis allele 34 (ST3) as compared with control subjects. In 21 studies, efficacy of treatment with antiparasitic drugs ranged from 0 to 100% (35.7% of 269 CSU patients benefitted). In 9 (42.8%) of 21 studies, more than 50% of efficacy was observed. The reported rate of urticaria comorbidity in PI patients in 18 independent studies is 1-66.7%. Urticaria including CSU might be a quite common symptom of strongyloidiasis and blastocystosis. Pathogenic mechanisms in CSU due to PI may include specific IgE, Th2 cytokine skewing, eosinophils, activation of the complement, and the coagulation systems.

  1. Dicty_cDB: VSJ547 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 70631.1 CSU-K33r.3H14.SP6 CSU-K33r Aedes aegypti genomic clone CSU-K33r.3H14, DNA sequence. 38 0.027 2 AF060264 |AF060264.1 Neochanna...ete sequence. 36 0.55 2 AF060265 |AF060265.1 Neochanna diversus strain Kaimaumau26 mitochondrial D-loop, com...plete sequence. 36 0.56 2 AF060263 |AF060263.1 Neochanna diversus strain Kaimaumau20 mitochondrial D-loop, c...omplete sequence. 36 0.56 2 AF060262 |AF060262.1 Neochanna diversus strain Kaimau

  2. Mediators of Inflammation and Angiogenesis in Chronic Spontaneous Urticaria: Are They Potential Biomarkers of the Disease?

    Directory of Open Access Journals (Sweden)

    Ilaria Puxeddu

    2017-01-01

    Full Text Available In chronic spontaneous urticaria (CSU, different pathophysiological mechanisms, potentially responsible for the development of the disease, have been recently described. It is likely that the activation of skin mast cells with consequent release of histamine and other proinflammatory mediators is responsible for vasodilation in the lesional skin of CSU. However, the underlying causes of mast cell activation in the disease are largely unknown and remain to be identified. Thus, in this review, we discuss new insights in the pathogenesis of CSU, focusing on inflammation and angiogenesis. The understanding of these mechanisms will enable the identification of biomarkers useful for the diagnosis, follow-up, and management of CSU and will allow the development of novel, more specific, and patient-tailored therapies.

  3. Valimised tõid segaduse / Aino Siebert

    Index Scriptorium Estoniae

    Siebert, Aino

    2005-01-01

    Saksa Bundestagi 16. valimistel ei saanud uue valitsuse loomiseks enamust ei CDU/CSU-blokk (Kristlik-Demokraatlik Liit ja Kristlik-Sotsiaalne Liit) ega SPD (Sotsiaaldemokraatlik Partei). Vt. ka: Kantslerikandidaat tuleb idast. Saksamaa kantslerikandidaat Angela Merkel

  4. Evaluation and improvement of the cloud resolving model component of the multi-scale modeling framework

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Kuan-Man; Cheng, Anning

    2009-10-01

    Developed, implemented and tested an improved Colorado State University (CSU) SAM (System for Atmospheric Modeling) cloud-resolving model (CRM) with the advanced third-order turbulence closure (IPHOC).

  5. A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria

    DEFF Research Database (Denmark)

    Iqbal, Kamran; Bhargava, Kapil; Skov, Per Stahl;

    2012-01-01

    ABSTRACT: The electronic records of 398 patients with chronic spontaneous urticaria (CSU) who had had a serum basophil histamine release assay (BHRA) performed as a marker of functional autoantibodies were audited. The BHRA was positive in 105 patients (26.4%). Fifty eight were treated with ciclo...... with ciclosporin because they were H1 anti-histamine unresponsive. CSU patients with a positive BHRA were more likely to respond clinically (P...

  6. Transition and Transversion Mutations Are Biased towards GC in Transposons of Chilo suppressalis (Lepidoptera: Pyralidae

    Directory of Open Access Journals (Sweden)

    Guang-Hua Luo

    2016-09-01

    Full Text Available Transposons are often regulated by their hosts, and as a result, there are transposons with several mutations within their host organisms. To gain insight into the patterns of the variations, nucleotide substitutions and indels of transposons were analysed in Chilo suppressalis Walker. The CsuPLE1.1 is a member of the piggyBac-like element (PLE family, which belongs to the DNA transposons, and the Csu-Ty3 is a member of the Ty3/gypsy family, which belongs to the RNA transposons. Copies of CsuPLE1.1 and Csu-Ty3 were cloned separately from different C. suppressalis individuals, and then multiple sequence alignments were performed. There were numerous single-base substitutions in CsuPLE1.1 and Csu-Ty3, but only a few insertion and deletion mutations. Similarly, in both transposons, the occurring frequencies of transitions were significantly higher than transversions (p ≤ 0.01. In the single-base substitutions, the most frequently occurring base changes were A→G and T→C in both types of transposons. Additionally, single-base substitution frequencies occurring at positions 1, 2 or 3 (pos1, pos2 or pos3 of a given codon in the element transposase were not significantly different. Both in CsuPLE1.1 and Csu-Ty3, the patterns of nucleotide substitution had the same characteristics and nucleotide mutations were biased toward GC. This research provides a perspective on the understanding of transposon mutation patterns.

  7. Members of the German Federal Parliament Research Committee visiting ALICE experiment on Wednesday, 15th November.

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    From left to right Mr Georg Jürgens, Counsellor at the German Mission in Geneva; MdB Klaus Hagemann, SPD; MdB Cornelia Pieper, FDP, Stellvertretende Ausschussvorsitzende, Delegationsleiterin; MdB Dr. Petra Sitte, DIE LINKE; MdB Ilse Aigner, CDU/CSU; MdB Carsten Müller, CDU/CSU; Mr Andreas Meyer, Leiter Ausschusssekretariat; MdB Jörg Tauss, SPD.

  8. Dicty_cDB: CHM171 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 6 CSU-K33r Aedes aegypti genomic clone CSU-K33r.25G4, DNA sequence. 50 0.059 1 CX053834 |CX053834.1 UCRCS09_8E08_g Ruby Orange Develo...ping Seed cDNA Library UCRCS09 Citrus sinensis cDNA clone UCRCS09-8E08-I15-1-5.g, m

  9. Accompanying conditions in patients with chronic spontaneous urticaria and urticarial vasculitis: Results of a retrospective study

    Directory of Open Access Journals (Sweden)

    Sevgi Akarsu

    2015-03-01

    Full Text Available Background and Design: Chronic spontaneous urticaria (CSU, the most common form of chronic urticaria, is characterized by spontaneous wheals and/or angioedema lasting longer than six weeks. Urticarial vasculitis (UV is a small vessel vasculitis; but is also included in the various classification systems of chronic urticaria by some authors. The aim of our study was to evaluate the frequency of accompanying conditions, and to compare the demographic, clinical and laboratory features of patients with CSU and UV. Materials and Methods: In this study, the files of CSU (n=146 and UV (n=43 patients who had been hospitalized between January 2010-December 2013 were retrospectively reviewed in terms of demographic data, disease-specific history, accompanying diseases, medications and laboratory findings. Results: When comparing between the two groups for statistical differences, it was found that the frequencies of personal atopy and angioedema were significantly higher in patients with CSU; however, the patients with UV had significantly higher rates for female gender and the presence of systemic symptoms compared to those with CSU. It was determined that the mean values for erythrocyte sedimentation rate and C-reactive protein, as well as the rates of antinuclear antibody positivity and hypocomplementemia were significantly higher in the UV group, compared with those in the CSU group. Accompanying factors were determined as infections, medications, autoimmune diseases and malignities in order of frequency in both CSU and UV groups, but only the frequency of autoimmune diseases was significantly higher in patients with UV group. Conclusion: Although various authors have reported that a large number (up to 40-60% of patients with UV may present only with wheals (clinically indistinguishable from CSU; we assumed that it would be more appropriate to be considered UV as a priority in patients especially who had systemic symptom, autoimmune disease

  10. Activation of coagulation in chronic urticaria in relation to disease severity and activity.

    Science.gov (United States)

    Farres, M N; Refaat, M; Melek, N A; Ahmed, E E; Shamseldine, M G; Arafa, N A

    2015-01-01

    The pathogenesis of chronic urticaria is incompletely understood. There is growing interest in the role of the coagulation cascade in chronic urticaria. We aimed to assess the possible activation of the coagulation cascade in chronic spontaneous urticaria (CSU) in relation to disease severity and activity. This study was conducted on 30 patients with active CSU and 30 apparently healthy individuals as controls. Patients with acute urticaria, physical urticaria, or any form of urticaria other than spontaneous urticaria were excluded. Plasma levels of D-dimer and activated factor VII (FVIIa) were measured by ELISA at baseline for all recruited patients and controls. In addition, they were measured for CSU patients after complete disease remission. Plasma levels of D-dimer and FVIIa were significantly higher among patients with active CSU than among healthy controls. D-dimer levels were lowest among patients with grade 1 severity and highest among those with grade 4 severity. Factor VIIa levels did not differ significantly according to disease severity grades. After complete disease remission, there was a significant dramatic drop in levels of D-dimer and FVIIa among patients. We conclude that activation of the coagulation cascade occurs in CSU, and we demonstrate the novel finding that activated factor VII levels are significantly reduced after medical therapy, confirming the implication of the extrinsic pathway activation in CSU. Future controlled studies may investigate the role of anticoagulant therapy in refractory chronic urticaria. Copyright © 2014 SEICAP. Published by Elsevier Espana. All rights reserved.

  11. The Clinical Correlations of Helicobacter pylori Virulence Factors and Chronic Spontaneous Urticaria

    Directory of Open Access Journals (Sweden)

    Yi-Chun Chiu

    2013-01-01

    Full Text Available Background and Study Aims. The association between Helicobacter pylori (H. pylori and chronic spontaneous urticaria (CSU remains controversial. This study explored the role of H. pylori in CSU among different virulent genotypes patients. Patients and Methods. Patients infected by H. pylori were sorted into two groups as group A (with CSU and group B (without CSU. The tissue materials were taken via endoscopy for polymerase chain reaction study to determine virulence factors. After H. pylori eradication therapy, the eradication rate and response of urticaria were evaluated by using C13-UBT and a three-point scale (complete remission, partial remission, or no improvement. Results. The results were comparable between patients of groups A and B in terms of H. pylori infection rates and eradication rate. Longitudinal follow-up of 23.5 months showed complete remission of urticaria in 63.6% but no improvement in 36.4% of the patients after H. pylori eradication. H. pylori infected patients with different virulence factors such as cytotoxin-associated gene A, vacuolating cytotoxin gene A signal region and middle region have similar remission rates for CSU. Conclusions. Current study suggests that H. pylori may play a role in the development and disease course of CSU but may be irrelevant to different virulent genotypes.

  12. Investigation of science faculty with education specialties within the largest university system in the United States.

    Science.gov (United States)

    Bush, Seth D; Pelaez, Nancy J; Rudd, James A; Stevens, Michael T; Tanner, Kimberly D; Williams, Kathy S

    2011-01-01

    Efforts to improve science education include university science departments hiring Science Faculty with Education Specialties (SFES), scientists who take on specialized roles in science education within their discipline. Although these positions have existed for decades and may be growing more common, few reports have investigated the SFES approach to improving science education. We present comprehensive data on the SFES in the California State University (CSU) system, the largest university system in the United States. We found that CSU SFES were engaged in three key arenas including K-12 science education, undergraduate science education, and discipline-based science education research. As such, CSU SFES appeared to be well-positioned to have an impact on science education from within science departments. However, there appeared to be a lack of clarity and agreement about the purpose of these SFES positions. In addition, formal training in science education among CSU SFES was limited. Although over 75% of CSU SFES were fulfilled by their teaching, scholarship, and service, our results revealed that almost 40% of CSU SFES were seriously considering leaving their positions. Our data suggest that science departments would likely benefit from explicit discussions about the role of SFES and strategies for supporting their professional activities.

  13. Oxidative Stress in Children with Chronic Spontaneous Urticaria

    Directory of Open Access Journals (Sweden)

    Fatih Dilek

    2016-01-01

    Full Text Available The pathogenesis of chronic spontaneous urticaria (CSU has not been fully understood; nevertheless, significant progress has been achieved in recent years. The aim of this study was to investigate the possible role of reactive oxygen species (ROS in the pathogenesis of CSU. Sixty-two children with CSU and 41 healthy control subjects were enrolled in the study. An extensive evaluation of demographic and clinical features was done, and serum oxidative stress was evaluated by plasma total oxidant status (TOS and total antioxidant status (TAS measurements. The median value of plasma TOS was found to be 10.49 μmol H2O2 equiv./L (interquartile range, 7.29–17.65 in CSU patients and 7.68 μmol H2O2 equiv./L (5.95–10.39 in the control group. The difference between the groups was statistically significant (p=0.003. Likewise, the median plasma TAS level in the CSU group was decreased significantly compared to that of the control group (2.64 [2.30–2.74] versus 2.76 [2.65–2.86] mmol Trolox equiv./L, resp., p = 0,001. Our results indicated that plasma oxidative stress is increased in children with CSU when compared to healthy subjects, and plasma oxidative stress markers are positively correlated with disease activity.

  14. Is There an Association between Restless Legs Syndrome and Urticaria?

    Science.gov (United States)

    Tuna, Serpil; Alan, Sevil; Samancı, Nehir; Karakaş, Ayşe Akman

    2016-05-01

    Restless legs syndrome (RLS) is a disease characterized by the urge to move the legs and sleep disturbances. Similarly, chronic spontaneous urticaria (CSU) is a dermatological disease characterized by pruritus and sleep disorders. In this study, we aimed to determine the prevalence and severity of RLS in patients with chronic spontaneous urticaria (CSU) and to compare the quality of sleep of patients with and without RLS in the CSU group using the Pittsburgh Sleep Quality Index. A total of 130 patients with CSU and 100 healthy controls were included in this study. The frequency of RLS, frequency of sleep disturbances, and average score of RLS in patients with CSU were statistically significantly higher than control groups (respectively P = 0.008, P = 0.009, P = 0.004). Subjective sleep quality, sleep latency and habitual sleep efficiency scores in patients with RLS were statistically significantly higher than patients without RLS (respectively P = 0.016, P = 0.007, P = 0.035). We claimed that pruritus of urticaria may decrease the quality of sleep in patients with RLS and it may trigger and worsen the restless legs syndrome. Furthermore, RLS and CSU may share a common etiology.

  15. THE ECONOMIC EVALUATION OF FOREST ROAD BUILDING

    OpenAIRE

    Muška, Aina; Bičevskis, Matīss

    2010-01-01

    Forest road density in Latvia is insufficient, although the Joint Stock Company ‘‘Latvijas valsts meži” (“Latvian State Forestry”) performs active forest road building. The hypothesis of the research is that the resources invested in a forest road building pay off during its use. The goal of the research is to study the economic benefit from forest road building. The authors’ research showed that the total costs of forest road building and use could result in Ls 246,779 over 40 years or Ls 6,...

  16. Eiropas un starptautiskie standarti cilvēku tirdzniecības apkarošanai un to ietekme uz Gruzijas likumdošanu un praksi

    OpenAIRE

    Kukhianidze, Ketevan

    2010-01-01

    Katru dienu vairāki tūkstoši cilvēku dodas uz dažādām valstīm labākas dzīves meklējumos. Mūsdienās verdzība un cilvēku tirdzniecība atspoguļo nopietnus cilvēktiesību pārkāpumus. Tā ir problēma, kas ietver sociālos, politiskos un demogrāfiskos aspektus, dzimumu un etnisko noslāņošanos, organizēto transnacionālo noziedzību un cilvēktiesību pārkāpumus, un iesaista valsts un supranacionālas institūcijas, lai tās efektīvi cīnītos ar šīm problēmām. Maģistra darbā „Eiropas un starptautiskie stand...

  17. Preču zīmju datubāzes Eiropas intelektuālā īpašuma aizsardzības nacionālajās institūcijās

    OpenAIRE

    Kurzemniece, Anda

    2006-01-01

    Viens no rūpnieciskā īpašuma veidiem ir preču zīmes. Tās ieņem nozīmīgu lomu katra uzņēmuma darbībā un attīstībā. Katras valsts nacionālā intelektuālā īpašuma institūcija veido valsts preču zīmju reģistru, un mūsdienās lielākajā daļā valstu ir pieejamas preču zīmju datubāzes. Pētījumā tiek aplūkotas Eiropas intelektuālā īpašuma institūciju preču zīmju brīvpieejas datubāzes. Pētījums sastāv no trīs nodaļām. Pirmajā nodaļā tiek aplūkoti preču zīmju viedi, funkcijas, preču zīmju reģistrācija un ...

  18. Iedzīvotāju ienākuma nodokļa ietekme uz iedzīvotāju dzīves līmeni

    OpenAIRE

    Putniņš, Dairis

    2010-01-01

    Diplomdarba tēma „Iedzīvotāju ienākuma nodokļa ietekme uz iedzīvotāju dzīves līmeni” šobrīd sabiedrībā ir aktuāla, jo iedzīvotāju ienākuma nodoklis ir svarīga ienākumu sastāvdaļa gan Latvijas valsts budžetā, gan arī pašiem iedzīvotājiem. Visi nodokļi Latvijā tiek balstīti uz vienotu nodokļu politiku, kas ir viens no svarīgākajiem instrumentiem valsts ekonomikas attīstības veidošanā un iedzīvotāju dzīves līmeņa paaugstināšanā. Šobrīd priekšroka gan tiek dota tam, lai tiktu palielināti budžeta ...

  19. Inovāciju veidotāju - zinātnes un rūpniecības uzņēmumu sadarbības loma un industriālās politikas kontekstā

    OpenAIRE

    Akmene, Anna

    2013-01-01

    Darbā tiek apskatīta industriālās un inovāciju politikas loma valsts ekonomiskajā politikā,konkurētspēja,Triple Helix modeļa teorētiskais pamatojums kā arī apskatīts labās prakses piemērs - Somija,kas ir uz zināšanām balstītas ekonomikas piemērs pasaulei,teicami parādot valsts lomu pārmaiņu veikšanā un Triple Helix modeļa realizāciju attīstības politikā.Tāpat darbā tiek identificētas līdzšinējās zinātnes un rūpniecības sadarbības problēmas kā arī tiek piedāvāts risinājums Somijas politikas u...

  20. Laika jēdziena salīdzināšana biznesa vidē dažādās kultūrās

    OpenAIRE

    2013-01-01

    Šis darbs analizē izmaiņas citā kultūrvidē strādājošo latviešu laika uztverē. Lai veiktu šo pētījumu, pirmkārt, tika apskatītas teorijas, kas saistītas ar laika jēdzienu. Otrkārt, darba autore izveidoja aptauju darba praktiskās daļas veikšanai. Treškārt, tika analizētas 25 ārpus valsts strādājošo respondentu laika uztveres izmaiņas. Darba galvenie secinājumi parādīja, ka ārpus valsts dzīvojošo un strādājošo latviešu laika uztvere mainās balstoties uz mītnes zemes kultūras laika uztveri un ka ...

  1. Publiskā un Privātā partnerība, administratīvo pārkāpumu lietā izņemto transportlīdzekļu nogādāšanai glabāšanā un glabāšana

    OpenAIRE

    Skrastiņš, Oskars

    2009-01-01

    Maģistra darba tēma ir Publiskā un Privātā partnerība, administratīvo pārkāpumu lietā izņemto transportlīdzekļu nogādāšanai glabāšanā un glabāšana. Darbā tiek pievērsta uzmanība valsts un privātajai partnerībai, tiek izskaidrota tās loma un sadarbības iespējas ar dažādām valsts un pašvaldību institūcijām, kur galvenā priekšrocība ir spējai apvienot publiskā un privātā sektora stiprās puses, izmantojot privātā komersanta novitāti pakalpojumu sniegšanā, nodrošinot kvalitatīvus pakalpojumus p...

  2. Living with Chronic Spontaneous Urticaria in Italy: A Narrative Medicine Project to Improve the Pathway of Patient Care.

    Science.gov (United States)

    Cappuccio, Antonietta; Limonta, Tommaso; Parodi, Aurora; Cristaudo, Antonio; Bugliaro, Filomena; Cannavò, Serafinella P; Rossi, Oliviero; Gurioli, Carlotta; Vignoli, Alice; Parente, Roberta; Iemoli, Enrico; Caldarola, Giacomo; De Pità, Ornella; Di Nuzzo, Sergio; Cancian, Mauro; Potenza, Concetta; Caminati, Marco; Stingeni, Luca; Saraceno, Rosita; Trevisini, Sara; Piccirillo, Angelo; Sciarrone, Claudio; Panebianco, Rosanna; Gola, Massimo; Costanzo, Antonio; Grieco, Teresa; Massaroni, Katia; Reale, Luigi; Marini, Maria G

    2017-01-04

    Chronic spontaneous urticaria (CSU) is perceived as a difficult to manage disease with negative impact on quality of life. The aim of this study was to highlight how to improve the care of people with CSU, using the methodology of narrative medicine. From June 2014 to March 2015, CSU-diagnosed patients and their physicians were asked to record their experiences of the condition in writing. Fourteen healthcare teams participated: 41% considered CSU as a challenge to overcome, while 22% experienced CSU as a big commitment. The number of professional involved was evaluated as insufficient in 11 hospitals. Seventy-five percent of the 190 Italian patients had visited 3 or more physicians before receiving a final diagnosis, with a perceived waste of time and resources. The therapeutic pathways were described as unsatisfactory in 83% of cases. As a result, anger and frustration were life-dominant emotions in 92% of patients. The critical points of the care pathway are related to organizational issues and lack of awareness.

  3. Managing urticaria in primary care.

    Science.gov (United States)

    Tidman, Michael J

    2015-02-01

    Urticaria is characterised by transient wheals that consist of a swollen palpable centre often surrounded by an erythematous flare, associated with itching or, less commonly, a burning sensation. Individual wheals usually disappear within 1 to 24 hours leaving normal skin. Wheals may be accompanied by angioedema, a more deep-seated flesh-coloured or erythematous swelling of skin or mucous membrane, which may last longer than 24 hours. Urticaria is classified as acute when it resolves within six weeks and chronic when its duration exceeds six weeks. Chronic urticaria is now sub-classified into chronic spontaneous urticaria (CSU) and chronic inducible urticaria. The prognosis for eventual recovery from spontaneous and inducible urticaria is excellent. However, the time course is unpredictable and may extend to years, often following a relapsing and remitting course. Urticaria results from the release of inflammatory mediators from dermal mast cells, resulting in vasodilatation, plasma extravasation, recruitment of immunologically active cells and sensory nerve stimulation. The cause of urticaria cannot usually be precisely identified for most affected individuals. IgE-mediated food allergy is rarely the cause of CSU in patients with the daily appearance of urticarial lesions, although it should be considered in CSU patients with intermittent symptoms. For patients with CSU a differential full blood count and inflammatory markers are all that are routinely recommended. It is also reasonable to test thyroid function and check for circulating thyroid autoantibodies as there is an association between CSU and thyroid autoimmunity.

  4. Caesium diuranium hexatelluride

    Directory of Open Access Journals (Sweden)

    Adel Mesbah

    2012-10-01

    Full Text Available Single crystals of CsU2Te6 were synthesized from the reaction of U, Te, and Cs2Te3 at 1273 K. CsU2Te6 crystallizes in the space group Cmcm in the CsTh2Te6 structure type. The asymmetric unit comprises one U (site symmetry m2m, one Cs (m2m; half-occupancy and two Te atoms (m.. and m2m. The structure of CsU2Te6 consists of infinite [U2Te6] layers perpendicular to [010] separated by Cs atoms. There are infinite Te—Te—Te linear chains along [001].

  5. Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on h1 antihistamines

    DEFF Research Database (Denmark)

    Saini, Sarbjit S; Bindslev-Jensen, Carsten; Maurer, Marcus;

    2015-01-01

    ASTERIA I was a 40-week, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of subcutaneous omalizumab as add-on therapy for 24 weeks in patients with chronic idiopathic urticaria/spontaneous urticaria (CIU/CSU) who remained symptomatic despite H1 antihistamine...... treatment at licensed doses. Patients aged 12-75 years with CIU/CSU who remained symptomatic despite treatment with approved doses of H1 antihistamines were randomized (1:1:1:1) in a double-blind manner to subcutaneous omalizumab 75 mg, 150 mg, or 300 mg or placebo every 4 weeks for 24 weeks followed by 16...... event. Omalizumab 300 mg administered subcutaneously every 4 weeks reduced weekly ISS and other symptom scores versus placebo in CIU/CSU patients who remained symptomatic despite treatment with approved doses of H1 antihistamines....

  6. ''Improving the EEG''. PHOTON discussion with experts of German political parties on the future of reimbursement for alternative energy; ''Das EEG weiter entwickeln''. PHOTON-Streitgesprach mit Energie-Experten der Bundestagsfraktionen ueber die kuenftige Solarstromfoerderung

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2002-08-01

    In a PHOTON discussion with Rainer Brinkmann (SPD), Franz Obermeier (CSU), Hans-Josef Fell (Buendnis 90/Die Gruenen), Walter Hirche (FDP) and Eva Bullinger-Schrter (PDS), it became clear that the FDP is not the only political party in Germany to oppose the EEG (Renewable Energy Act). The CSU is thinking about replacing reimbursement for alternative energy sources by a tendering procedure. [German] Weil Wahlprogramme sich meist in Allgemeinplaetzen verlieren, baten wir Energie-Experten aus den fuenf Bundestagsfraktionen in einem Streitgespraech um Klartext: Wie sehen die Plaene zur Solarstromfoerderung aus? Bei der lebhaften Diskussion zwischen Rainer Brinkmann (SPD), Franz Obermeier (CSU), Hans-Josef Fell (Buendnis 90/Die Gruenen), Walter Hirche (FDP) und Eva Bulling-Schroeter (PDS) wurde deutlich: Nicht nur die FDP ist gegen das Erneuerbaree-Energien-Gesetz (EEG). Auch in der Union gibt es Ueberlegungen, die Einspeiseverguetung fuer Solarstrom durch einen Ausschreibungswettbewerb abzuloesen. (orig.)

  7. Probiotics and refractory chronic spontaneous urticaria.

    Science.gov (United States)

    Nettis, E; Di Leo, E; Pastore, A; Distaso, M; Zaza, I; Vacca, M; Macchia, L; Vacca, A

    2016-09-01

    Background. In chronic spontaneous urticaria (CSU) first-line therapy with an antihistamine-based regimen may not achieve satisfactory control in patients. Thus, a continuing need exists for effective and safe treatments for refractory CSU. Aim. To evaluate the clinical efficacy and safety of an intake of a combination of 2 probiotics (Lactobacillus salivarius LS01 and Bifidobacterium breve BR03) in patients with CSU who remain symptomatic despite concomitant H1-antihistamine therapy. Methods. This report analyzes the effects of therapy with two probiotic strains on the clinical progress of 52 unselected patients with difficulty to treat CSU underwent to medical examination in two Italian specialist urticaria Clinics between September 2013 and September 2014. A mixture of Lactobacillus LS01 and Bifidobacterium BR03 were administered in each patient twice daily for 8 weeks. To evaluate patients' improvement with probiotics, urticaria activity score over 7 days (UAS7) was used at baseline and at week 8 in addition to a 5-question urticaria quality of life questionnaire. Results. Fifty-two patients with CSU were included in this study (10 male and 42 female, age range 19-72 years). Mean disease duration was 1.5 years. Fourteen patients discontinued treatment, so evaluable population consisted of 38 patients. Nine of the 38 patients experienced mild clinical improvement during probiotic treatment (23.7%); one patient reported significant clinical improvement (2.6%) and one patient had complete remission of urticaria (2.6%). Twenty-seven patients did not have improvement in symptoms (71.1%). No side effects during the course of therapy were reported. Conclusions. A combination of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03 administered twice daily for 8 weeks might reduce the symptoms scores and improve quality of life scores in a part of patients with CSU who remained symptomatic despite treatment with H1 antihistamine mostly in subjects with allergic

  8. Histamine release positive test associates with disease remission in chronic spontaneous urticaria

    DEFF Research Database (Denmark)

    Berti, A; Yacoub, M R; Skov, Per Stahl

    2017-01-01

    Summary: Background. Histamine release (HR) test has previously been shown to predict the presence of endogenous histamine-releasing factors in chronic spontaneous urticaria (CSU). Objectives and methods. Twenty CSU patients unresponsive to antihistamine treatment were enrolled in order to evaluate...... the correlations between HR test results and demographic features, quality of life, disease activity, clinical course, and autologous serum and plasma skin tests (ASST and APST). Results. All patients with positive HR test (9/9, 100%) had a more severe disease activity at onset (urticaria activity score, UAS > 2...

  9. Latvijas Neredzīgo bibliotēkas pakalpojumu kvalitāte lietotāju vērtējumā

    OpenAIRE

    2013-01-01

    2011. gadā akreditācijas komisija konstatēja, ka Latvijas Neredzīgo bibliotēkas darbība neatbilst valsts nozīmes bibliotēkas statusa iegūšanai. Bibliotēkas veiktās lietotāju aptaujas rezultāti arī apliecina, ka lietotāji vēlētos, lai pakalpojumu sistēma tiktu pilnveidota. Tāpēc maģistra darbā tiek izzināts, vai ir atšķirības starp lietotāju vēlmēm un reāli saņemtajiem pakalpojumiem. Kā pētniecības metodes izmantota lietotāju aptauja (anketēšana), intervijas un situācijai adaptētais SERVQUAL m...

  10. Satura pārvaldības sistēmas Joomla! paplašinājumu izstrāde

    OpenAIRE

    Zariņa, Evita

    2012-01-01

    Kvalifikācijas darbā tika izstrādāti Joomla paplašinājumi. Viens no tiem bija notikumu kalendārs, kas tika veidots SIA „Datorikas institūts DIVI” un AS „Latvijas valsts meži” sadarbības līguma „Par satura pārvaldības sistēmas un WEB portāla izstrādi, izvietošanu un 3 gadu uzturēšanu” ietvaros. Tā izveidošanā tika izmantots atklātā pirmkoda paplašinājums „PHP Quick Calendar E”, kura pirmkodā tika veiktas izmaiņas, balstoties uz GNU Vispārējo publisko licenci. Izstrādātais paplašinājums ļauj ad...

  11. Zīmolvedības ietekme uz patērētāju izvēli

    OpenAIRE

    Kozlovska-Zilvestere, Anete

    2010-01-01

    Bakalaura darba tēma ir „Zīmolvedība un Coca – Cola zīmola ietekme uz patērētāju”. Bakalaura darba mērķis ir salīdzināt Coca – Cola zīmola ietekmi Latvijas Universitātes un Rostokas Universitātes, Vācijā, studentu vidū ar Pepsi zīmola ietekmi; izstrādāt priekšlikumus zīmola veiksmīgākai virzīšanai šajās valstīs, atbilstoši zīmolvedības pamatprincipiem.

  12. Eiropas Savienības politika Austrumu partnerības attīstībai: Austrumu partnerības samitu loma.

    OpenAIRE

    Šķendere, Ieva

    2015-01-01

    Maģistra darbs „Eiropas Savienības politika Austrumu partnerības attīstībai: Austrumu partnerības samitu loma” ir veltīts Austrumu partnerības attīstības izpētei, ko veicinājusi Eiropas Savienības Kaimiņvalstu politika. Austrumu partnerība ir viena no ES ārējās politikas prioritātēm, tāpēc tās ietvaros dažādās formās tiek stiprināta sadarbība ar Austrumu partnerības valstīm, lai caur savstarpēju ekonomisku un politisku attiecību veidošanu ES nodrošinātu ekonomisku, politisku stabilitāti un mi...

  13. Trigonometrijas nozīme vidusskolas ģeometrijas kursā

    OpenAIRE

    Apine, Aiga

    2006-01-01

    Diplomdarba mērķis ir parādīt trigonometrijas nozīmi vidusskolas ģeometrijas kursā, kā arī rast idejas tās interesantākai pasniegšanai, izmantojot trigonometrijas attīstības vēsturi un uzdevumus, kas cieši saistīti ar sadzīvi. Darbā tiek aplūkoti ģeometrijas uzdevumi pēc izglītības standartā noteiktajiem dokumentiem, šo uzdevumu risināšanas metodes, pielietojot zināšanas trigonometrijā. Kā arī izveidota statistika par valsts pārbaudījuma darbiem matemātikā no 1997. – 2005.gadam, izceļot ģe...

  14. [Smoļenskas-Rīgas aktis 13. gs.-14. gs. pirmā puse : kompleksa "Moscowitica-Ruthenica" dokumenti par Smoļenskas un Rīgas attiecībām = Смоленско-рижские акты XIII в.-первая половина XIV в. : документ�

    Index Scriptorium Estoniae

    Levans, Andris, 1968-

    2011-01-01

    Arvustus: Smoļenskas-Rīgas aktis 13. gs.-14. gs. pirmā puse : kompleksa "Moscowitica-Ruthenica" dokumenti par Smoļenskas un Rīgas attiecībām = Смоленско-рижские акты XIII в.-первая половина XIV в. : документы комплекса Moscowitica-Ruthenica об отношениях Смоленска и Риги /koostajad Leksanders Ivanovs, Anatolijs Kuzņcovs. Vēstures avoti ; 6 (Riga: Latvijas Valsts vēstures arcīva izdevniecība, 2009)

  15. [Smoļenskas-Rīgas aktis 13. gs.-14. gs. pirmā puse : kompleksa "Moscowitica-Ruthenica" dokumenti par Smoļenskas un Rīgas attiecībām = Смоленско-рижские акты XIII в.-первая половина XIV в. : документ�

    Index Scriptorium Estoniae

    Levans, Andris, 1968-

    2011-01-01

    Arvustus: Smoļenskas-Rīgas aktis 13. gs.-14. gs. pirmā puse : kompleksa "Moscowitica-Ruthenica" dokumenti par Smoļenskas un Rīgas attiecībām = Смоленско-рижские акты XIII в.-первая половина XIV в. : документы комплекса Moscowitica-Ruthenica об отношениях Смоленска и Риги /koostajad Leksanders Ivanovs, Anatolijs Kuzņcovs. Vēstures avoti ; 6 (Riga: Latvijas Valsts vēstures arcīva izdevniecība, 2009)

  16. Mazumtirdzniecības uzņēmuma SIA Rimi Latvia noieta veicināšanas pasākumi Latvijas tirgū

    OpenAIRE

    Atāla, Vineta

    2010-01-01

    Vineta Atāla „Mazumtirdzniecības uzņēmuma SIA „Rimi Latvia” noieta veicināšanas pasākumi Latvijas tirgū”. Bakalaura darbā tiek pētīti un analizēti SIA „Rimi Latvia” noieta veicināšanas pasākumi Latvijas tirgum. Bakalaura darba tēma šobrīd ir aktuāla, jo pasliktinoties valsts ekonomiskajai situācijai uzņēmējiem ir intensīvāk jāpielieto noieta veicināšanas veidi, lai palielinātu pārdošanas apjomus un piesaistītu jaunus klientus, kā arī nodrošinātu veiksmīgu uzņēmējdarbību. Bakalaura darba...

  17. Higher Education in California: New Goals for the Master Plan

    Science.gov (United States)

    Johnson, Hans

    2010-01-01

    Fifty years ago, state policymakers and higher education officials adopted California's Master Plan for Higher Education. This plan still largely defines policies concerning the state's public higher education systems: the California community colleges (CCC), the California State University (CSU) system, and the University of California (UC)…

  18. 36 CFR 251.121 - Definitions.

    Science.gov (United States)

    2010-07-01

    .... Historical operator—a holder of a valid special use authorization to provide visitor services in a CSU under... section 102(6) of ANILCA (16 U.S.C. 3197). Preferred operator—a Native Corporation that is determined... as providing food, accommodations, transportation, tours, and outfitting and guiding, except...

  19. Dicty_cDB: CHI795 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nomic clone CSU-K33r.25G4, DNA sequence. 50 0.057 1 CX053834 |CX053834.1 UCRCS09_8E08_g Ruby Orange Develo...ping Seed cDNA Library UCRCS09 Citrus sinensis cDNA clone UCRCS09-8E08-I15-1-5.g, m

  20. British Joint Counter-Insurgency Doctrine - Chinese Whispers From the Past and a Doomed Future

    Science.gov (United States)

    2010-04-01

    CNN Cable News Network COBR Cabinet Office Briefings COIN Counter-Insurgency CSU Conflict Stabilisation Unit DfID Department for International...Concepts. piii. 63 Ibid. 64 Ibid., p1-8. 65 Cabinet Office Briefing ( COBR ) – COBR is the UK Government mechanism/organisation, which is activated

  1. Learning Fire Investigation the Clean Way: The Virtual Experience

    Science.gov (United States)

    Davies, Amanda; Dalgarno, Barney

    2009-01-01

    The effective teaching of fire investigation skills presents logistical challenges because of the difficulty of providing students with access to suitable fire damaged buildings so that they can undertake authentic investigation tasks. At Charles Sturt University (CSU), in the subject JST415, "Fire Investigation Cause and Origin…

  2. On Developing the Writing Skills Course for Accounting Students

    Science.gov (United States)

    Firch, Tim; Campbell, Annhenrie; Lindsay, David H.; Garner, Don E.

    2010-01-01

    The CSU, Stanislaus, accounting program is providing a new course that meets the university-wide upper-division writing requirement and offers accounting students additional professional study. While a writing skills course is not unusual in a business program, few offer an alternative centered on the accounting body of knowledge. Undergraduate…

  3. Factors That Affect the Academic Success of Foreign Students at Cardinal Stritch University

    Science.gov (United States)

    Annor, Peter

    2010-01-01

    There are limited studies in the literature on the factors that affect the academic success of foreign students in the United States. This ex post facto mixed method study investigated the factors that affect the academic success of foreign students at Cardinal Stitch University (CSU), a medium size, private university located in the Midwestern…

  4. Leveraging the Libguides Platform for Electronic Resources Access Assistance

    Science.gov (United States)

    Erb, Rachel A.; Erb, Brian

    2014-01-01

    This case study offers an alternative use of LibGuides beyond its intended purpose to offer course and subject guides. LibGuides have become an integral part of the virtual instruction landscape at Colorado State University (CSU) Libraries. We discovered that the LibGuides platform can also be effectively harnessed to provide support for…

  5. The first chimpanzee sanctuary in Japan: an attempt to care for the "surplus" of biomedical research.

    Science.gov (United States)

    Morimura, Naruki; Idani, Gen'ichi; Matsuzawa, Tetsuro

    2011-03-01

    This article specifically examines several aspects of the human-captive chimpanzee bond and the effort to create the first chimpanzee sanctuary in Japan. We discuss our ethical responsibility for captive chimpanzees that have been used in biomedical research. On April 1, 2007, the Chimpanzee Sanctuary Uto (CSU) was established as the first sanctuary for retired laboratory chimpanzees in Japan. This initiative was the result of the continuous efforts by members of Support for African/Asian Great Apes (SAGA), and the Great Ape Information Network to provide a solution to the large chimpanzee colony held in biomedical facilities. However, the cessation of invasive biomedical studies using chimpanzees has created a new set of challenges because Japan lacks registration and laws banning invasive ape experiments and lacks a national policy for the life-long care of retired laboratory chimpanzees. Therefore, CSU has initiated a relocation program in which 79 retired laboratory chimpanzees will be sent to domestic zoos and receive life-long care. By the end of 2009, the number of chimpanzees living at CSU had decreased from 79 to 59 individuals. A nationwide network of care facilities and CSU to provide life-long care of retired laboratory chimpanzees is growing across Japan. This will result in humane treatment of these research animals.

  6. University Preparation of Social Justice Leaders for K-12 Schools

    Science.gov (United States)

    Woods, Rosmary Sandie M.

    2012-01-01

    The purpose of this study was to examine the social justice principles embedded in California State University (CSU) Educational Administration Preparation Programs. More specifically, this study explored the intended, implemented, and assessed curriculum relative to social justice and critical consciousness, and investigated if differences exist…

  7. Refractory chronic spontaneous urticaria and permanent atrial fibrillation associated with dental infection: Mere coincidence or something more to it?

    Science.gov (United States)

    Kasperska-Zajac, Alicja; Grzanka, Alicja; Kowalczyk, Jacek; Wyszyńska-Chłap, Magdalena; Lisowska, Grażyna; Kasperski, Jacek; Jarząb, Jerzy; Misiołek, Maciej; Kalarus, Zbigniew

    2016-03-01

    Controversy surrounds the role of dental infection/inflammation in the oral cavity in chronic spontaneous urticaria (CSU) and atrial fibrillation (AF), which is mainly due to scarce literature in this area. Therefore, this case report and review of literature illustrate a possible association between the acute-phase response (APR) and clinical conditions, such as CSU and dental infection/inflammation of oral cavity and AF.We describe a 36-year-old man with an 8-year history of difficult-to-treat, uncontrolled CSU, co-existent with dental infection/inflammatory processes of oral cavity and permanent atrial fibrillation (AF). In the presented case, the most likely triggering or aggravating/maintaining factor of the symptoms was the inflammation/dental infection of the oral cavity because of rapid reduction of the urticarial symptoms, drug doses, and serum CRP levels after the dental therapy. Dental treatment may have a beneficial effect on the systemic inflammatory response, reducing/normalizing the circulating levels of APR markers. APR activation appears to worsen CSU course, early identification and treatment of infectious/inflammatory foci in the oral cavity would form the mainstay of supportive therapy for CU probably through reduction of the systemic inflammatory burden. APR associated with infectious/inflammatory foci in the oral cavity could be taken into account as a predisposing agents to AF.

  8. Thomas Edison State College and Colorado State University: Using Cutting-Edge Technology to Enhance CE Unit Success

    Science.gov (United States)

    van Zyl, Henry; Powell, Albert, Jr.

    2012-01-01

    Thomas Edison State College (TESC) and Colorado State University (CSU) offer significant contrasts in institutional culture, student demographics, faculty and institutional priorities and approaches to distance education course development and delivery. This article offers case studies showing that widely disparate program design and delivery…

  9. Management of urticaria: not too complicated, not too simple

    Science.gov (United States)

    Ferrer, M; Bartra, J; Giménez-Arnau, A; Jauregui, I; Labrador-Horrillo, M; Ortiz de Frutos, J; Silvestre, J F; Sastre, J; Velasco, M; Valero, A

    2015-01-01

    In spite of being an old disease and apparently easy to diagnose, chronic spontaneous urticaria (CSU) is still perceived as an uncontrollable and difficult to manage disease. The perception of the patient is that his/her condition is not well understood and that is suffering from a disorder with hidden causes that doctors are not able to tackle. Sometimes patients go through a number of clinicians until they found some CSU expert who is familiar with the disease. It is surprising that myths and believes with no scientific support still persist. Guidelines are not widely implemented, and recent tools to assess severity are infrequently used. European and American recent guidelines do not agree in several key points related to diagnosis and treatment, which further contributes to confusion. With the aim to clarify some aspects of the CSU picture, a group of allergists and dermatologists from the Spanish Dermatology and Allergy societies developed a Frequent Asked Questions leaflet that could facilitate physicians work in daily practice and contribute to a better knowledge of common clinical scenarios related to patients with CSU. PMID:25429900

  10. Autoreactive IgE in Chronic Spontaneous/Idiopathic Urticaria and Basophil/Mastocyte Priming Phenomenon, as a Feature of Autoimmune Nature of the Syndrome.

    Science.gov (United States)

    Panaszek, Bernard; Pawłowicz, Robert; Grzegrzółka, Jędrzej; Obojski, Andrzej

    2017-04-01

    Recent years of research have shed a new light on the role of IgE in immune reactions. It seems to be more than just a contribution to immediate type of allergic response. It appears that monomeric IgE may enhance mast cell activity without cross-linking of FcεRI by IgE specific allergen or autoreactive IgG anti-IgE antibodies. Monomeric IgE molecules are heterogeneous concerning their ability to induce survival and activation of mast cells only by binding the IgE to FcεRI, but not affecting degranulation of cells. It also turned out that IgE may react to autoantigens occurring in the blood not only in chronic spontaneous urticaria (CSU) but also in other autoimmune diseases. The aforementioned phenomena may promote the activity of mast cells/basophils in CSU that easily degranulate when influenced by various inner (autoreactive IgG against IgE and FcεRI, autoreactive IgE for self-antigens) and outer factors (cold, heat, pressure) or allergens. These findings forced the new approach to the role of autoimmunity, self-antigens and IgE autoantibodies in the pathology of CSU. CSU put in the scheme of autoreactive IgG and autoreactive IgE seems to be either a kind of an autoimmune disease or a clinical manifestation of some other defined autoimmune diseases or both.

  11. Richtlijn Chronische urticaria

    NARCIS (Netherlands)

    Urgert, M. C.; Knulst, A. C.

    2015-01-01

    The development of the new Dutch guideline on chronic urticaria started in 2014. In this multidisciplenary guideline, initiated by the NVDV, evidence for predefined outcomes were assessed using the EBRO and GRADE approach. This guideline discusses the nomenclature of CSU. In addition the guideline

  12. Challenge-proven aspirin hypersensitivity in children with chronic spontaneous urticaria.

    Science.gov (United States)

    Cavkaytar, Ozlem; Arik Yilmaz, Ebru; Buyuktiryaki, Betul; Sekerel, Bulent E; Sackesen, Cansin; Soyer, Ozge U

    2015-02-01

    Nonsteroidal anti-inflammatory drug (NSAID) exacerbated cutaneous disease is defined as the exacerbation of wheals and/or angioedema in patients with a history of chronic spontaneous urticaria (CSU). The objective of this study was to define 'aspirin-hypersensitive' children and adolescents in a clearly defined group of patients with CSU and to describe their clinical features. Eighty-one children with a history of CSU were enrolled over a 3-year period. The daily or almost daily (>4 days a week) presence of urticaria was defined as 'chronic persistent urticaria' (CPU), while the presence of urticaria for 2-4 days a week was defined as 'chronic recurrent urticaria' (CRU). Single-blind, placebo-controlled provocation tests (SBPCPTs) with aspirin were performed for children with CSU. Patients with CRU had a longer duration of cutaneous symptoms [1.6 (0.5-4) vs 0.6 (0.3-1.5) years], and stress was less frequently experienced as an eliciting factor in patients with CRU compared with the patients with CPU (P urticaria, determination of NSAID hypersensitivity in a well-controlled clinical setting will help to avoid severe drug hypersensitivity reactions. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  13. Leveraging the Libguides Platform for Electronic Resources Access Assistance

    Science.gov (United States)

    Erb, Rachel A.; Erb, Brian

    2014-01-01

    This case study offers an alternative use of LibGuides beyond its intended purpose to offer course and subject guides. LibGuides have become an integral part of the virtual instruction landscape at Colorado State University (CSU) Libraries. We discovered that the LibGuides platform can also be effectively harnessed to provide support for…

  14. Differences in Biofilm Mass, Expression of Biofilm-Associated Genes, and Resistance to Desiccation between Epidemic and Sporadic Clones of Carbapenem-Resistant Acinetobacter baumannii Sequence Type 191

    Science.gov (United States)

    Selasi, Gati Noble; Nicholas, Asiimwe; Jeon, Hyejin; Na, Seok Hyeon; Kwon, Hyo Il; Kim, Yoo Jeong; Heo, Sang Taek; Oh, Man Hwan; Lee, Je Chul

    2016-01-01

    Understanding the biology behind the epidemicity and persistence of Acinetobacter baumannii in the hospital environment is critical to control outbreaks of infection. This study investigated the contributing factors to the epidemicity of carbapenem-resistant A. baumannii (CRAB) sequence type (ST) 191 by comparing the differences in biofilm formation, expression of biofilm-associated genes, and resistance to desiccation between major epidemic (n = 16), minor epidemic (n = 12), and sporadic (n = 12) clones. Biofilm mass was significantly greater in the major epidemic than the minor epidemic and sporadic clones. Major and minor epidemic clones expressed biofilm-associated genes, abaI, bap, pgaABCD, and csuA/BABCDE, higher than the sporadic clones in sessile conditions. The csuC, csuD, and csuE genes were more highly expressed in the major epidemic than minor epidemic clones. Interestingly, minor epidemic clones expressed more biofilm-associated genes than the major epidemic clone under planktonic conditions. Major epidemic clones were more resistant to desiccation than minor epidemic and sporadic clones on day 21. In conclusion, the epidemic CRAB ST191 clones exhibit a higher capacity to form biofilms, express the biofilm-associated genes under sessile conditions, and resist desiccation than sporadic clones. These phenotypic and genotypic characteristics of CRAB ST191 may account for the epidemicity of specific CRAB ST191 clones in the hospital. PMID:27622249

  15. Evaluation of Student Engagement Assessment in Colorado State University's Warner College of Natural Resources

    Science.gov (United States)

    Holman, Debra Kaye

    2013-01-01

    The purpose of this mixed methods study was to conduct a participatory program evaluation of student engagement assessment in Colorado State University's (CSU) Warner College of Natural Resources (WCNR). The college requested the evaluation after completing two pilot studies of undergraduate engagement which led them to consider establishing the…

  16. The New Tax Credits: How Much Will They Offset Higher Student Fees in California? Report 09-22

    Science.gov (United States)

    Jones, Jessika

    2009-01-01

    The American Recovery and Reinvestment Act (ARRA) significantly increases federal tax credits for people who pay for college education. For many families, these tax credits will offset most of the recent fee increases at University of California (UC), California State University (CSU), and the community colleges. Some students will likely be…

  17. Adding a nitrogen footprint to Colorado State University’s sustainability plan

    Science.gov (United States)

    Kimiecik, Jacob; Baron, Jill; Weinmann, Timothy; Taylor, Emily

    2017-01-01

    As a large land grant university with more than 32,000 students, Colorado State University has both on-campus non-agricultural and agricultural sources of nitrogen (N) released to the environment. We used the Nitrogen Footprint Tool to estimate the amount of N released from different sectors of the university for the CSU 2014 academic year. The largest on campus sources were food production, utilities (heating, cooling, electricity), and research animals. The total on-campus N footprint in 2014 was 287 metric tons. This value was equivalent to the nitrogen footprint of agricultural experiment stations and other agricultural facilities, whose nitrogen footprint was 273 metric tons. CSU has opportunities to reduce its on-campus footprint through educational programs promoting low-meat diets and commuting by bicycle or bus. There is also an opportunity to advance ideas of agricultural best management practices, including precision farming and better livestock management. This article describes the planned and ongoing efforts to educate CSU about how societal activities release nitrogen to the environment, contributing to global change. It offers personal and institutional options for taking action, which would ultimately reduce CSU’s excess reactive nitrogen loss to the environment. The N-footprint for CSU, including scenarios of possible future nitrogen reductions, is also discussed.

  18. A Joyful and Exhilarating Ride: An Interview with Frank J. Vattano

    Science.gov (United States)

    Dik, Bryan J.

    2008-01-01

    Frank J. Vattano is Professor Emeritus of Psychology and Emeritus University Distinguished Teaching Scholar at Colorado State University (CSU), his undergraduate alma mater. He earned his PhD in experimental psychology from The Ohio State University and served as Associate Dean of Arts and Sciences and Vice Chancellor for Student Affairs at the…

  19. Omalizumab in patients with chronic spontaneous urticaria : A systematic review and GRADE assessment

    NARCIS (Netherlands)

    Urgert, M. C.; Van Den Elzen, M. T.; Knulst, A. C.|info:eu-repo/dai/nl/101112017; Fedorowicz, Z.; Van Zuuren, E. J.

    2015-01-01

    Summary Chronic spontaneous urticaria (CSU) is characterized by the occurrence of hives, angio-oedema or both for a period of at least 6 weeks. Many patients remain symptomatic despite treatment with H1 antihistamines, even at higher doses. This systematic review assessed the quality of t

  20. Report: Visit To California State University: Los Angeles And Dominquez Hills Campuses: 1-7 August 1999

    Directory of Open Access Journals (Sweden)

    Valerie Ehlers

    2001-01-01

    Full Text Available According to the California State University’s (CSU’s Chancellor, Professor CB Reed, the CSU is America’s largest senior system of higher education with 350 000 students on 22 campuses, situated throughout California. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  1. Deutsche Minderheit und deutsches Kulturerbe im Baltikum ist weiterhin präsent / Klaus Brähming

    Index Scriptorium Estoniae

    Brähming, Klaus

    2013-01-01

    Baltimaid külastas Saksa Bundestag'i CDU / CSU-bloki (Kristlik-Demokraatlik Liit ja Kristlik-Sotsiaalne Liit) delegatsioon. Tõdeti, et Baltimaades elab väike, ent see-eest väga aktiivne saksa vähemus. Delegatsioon avaldas soovi kultuurisuhete tugevdamiseks Baltimaadega

  2. Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontaneous urticaria

    NARCIS (Netherlands)

    van den Elzen, Mignon T; van Os-Medendorp, Harmieke|info:eu-repo/dai/nl/184246954; van den Brink, Imke; van den Hurk, Karin; Kouznetsova, Ouliana I; Lokin, Alexander S H J; Laheij-de Boer, Anna-Marijke|info:eu-repo/dai/nl/304818623; Röckmann, Heike|info:eu-repo/dai/nl/304810606; Bruijnzeel-Koomen, Carla A F M|info:eu-repo/dai/nl/074119893; Knulst, André C|info:eu-repo/dai/nl/101112017

    2017-01-01

    Background: Treatment with second-generation antihistamines is recommended in patients with chronic spontaneous urticaria (CSU). Some patients remain unresponsive even after up-dosing up to fourfold. Many third line treatment options have limited availability and/or give rise to significant side

  3. Quark masses without Yukawa hierarchies

    Energy Technology Data Exchange (ETDEWEB)

    Fanchiotti, H.; Garcia-Canal, C. [Plata Univ. Nacional, Laboratorio de Fisica Teorica, Dept. de Fisica, Facultad de Ciencias Exactas, La Plata (Argentina); Ponce, W.A. [Antioquia Univ., Instituto de Fisica, Colombia La (Argentina)

    2005-12-15

    A model based on the local gauge group SU(3){sub c}*SU(3){sub L}*U(1){sub X} without particles with exotic electric charges is shown to be able to provide the quark mass spectrum and their mixing, by means of universal see-saw mechanisms, avoiding a hierarchy in the Yukawa coupling constants. (authors)

  4. Aircraft/Stores Compatibility, Integration and Separation Testing (Essais de compatibilite, d’integration et de separation des emports sur aeronef)

    Science.gov (United States)

    2014-09-01

    Dynamics CFE Contractor Furnished Equipment CI Configuration Item CMA Classical (or Experimental) Modal Analysis CSC Computer Software Component CSU...a weapon designer/producer of the weapon, CFE weapon design data should be provided when CFE weapon equipment or modification of GFE are required

  5. The Impact of the College Assistance Migrant Program on Migrant Student Achievement in the California State University System

    Science.gov (United States)

    Ramirez, Adrian Dee

    2010-01-01

    The purpose of the 7-year longitudinal study was to examine the College Assistance Migrant Program (CAMP), a student services intervention, to determine its impact on migrant student achievement in the California State University (CSU) system. Participants included 336 migrant students who were enrolled as first-time, full-time freshmen in fall…

  6. Learning Fire Investigation the Clean Way: The Virtual Experience

    Science.gov (United States)

    Davies, Amanda; Dalgarno, Barney

    2009-01-01

    The effective teaching of fire investigation skills presents logistical challenges because of the difficulty of providing students with access to suitable fire damaged buildings so that they can undertake authentic investigation tasks. At Charles Sturt University (CSU), in the subject JST415, "Fire Investigation Cause and Origin…

  7. Nederlandse richtlijn Chronische urticaria - Behandeling met omalizumab

    NARCIS (Netherlands)

    Van Den Elzen, M. T.; Urgert, M. C.; Van Doorn, M. B A; Tupker, R. A.; Knulst, A. C.; Van Zuuren, E. J.

    2015-01-01

    The Dutch guideline Chronic Urticaria aims to present a stepped-care model for the treatment of chronic spontaneous urticaria (CSU). In this manuscript omalizumab is discussed as a treatment option. Omalizumab is a humanized monoclonal antibody that selectively binds to immunoglobulin E (IgE). We ha

  8. Richtlijn Chronische urticaria

    NARCIS (Netherlands)

    Urgert, M. C.; Knulst, A. C.

    2015-01-01

    The development of the new Dutch guideline on chronic urticaria started in 2014. In this multidisciplenary guideline, initiated by the NVDV, evidence for predefined outcomes were assessed using the EBRO and GRADE approach. This guideline discusses the nomenclature of CSU. In addition the guideline r

  9. The persistence of chronic spontaneous urticaria in childhood is associated with the urticaria activity score.

    Science.gov (United States)

    Arik Yilmaz, Ebru; Karaatmaca, Betul; Cetinkaya, Pinar Gur; Soyer, Ozge; Sekerel, Bulent E; Sahiner, Umit Murat

    2017-03-01

    There is little information regarding the etiology and natural course of chronic spontaneous urticaria (CSU) in childhood. To investigate the etiology, prognosis, and the factors associated with the prognosis of CSU in children. Data from children with CSU who had been diagnosed between 1992 and 2015 were analyzed. A telephone interview was done to assess the current status of these patients. Remission was defined as the disappearance of urticaria for >6 months. A total of 222 children with CSU were evaluated. The median age of symptom onset was 8.8 years (interquartile range [IQR], 4.6-12.3 years), median duration of urticaria was 23 months (IQR, 7-48 months), and the median sum of the daily urticaria activity score of 7 consecutive days (UAS7) was 28 (IQR, 21-42). Accompanying angioedema was reported by 107 patients (48.2%), whereas 27.1% of the study population had autoantibody positivity. Autologous serum skin testing results were positive in 43 (34.1%); skin-prick testing results revealed atopy in 55 children (27.9%). Parasites (4.8%), pollen sensitization (1.5%), food allergy (0.9%), urinary tract infection (0.9%), and Hashimoto thyroiditis (0.5%) were determined as etiologic factors of CSU. The patients were followed up for a median time of 15 months (IQR, 5-36.5 months). Remission was observed in 10.6, 29.3, and 44.5% of the patients in 1, 3, and 5 years, respectively. In multivariate regression analysis, a UAS7 of >28 at admission was found to be a risk factor for persistence of urticaria (odds ratio 6.22 [95% confidence interval, 1.54-25.15; p = 0.010). The etiology of CSU in children was mostly idiopathic despite detailed investigation. In childhood, the natural course of CSU was favorable, and nearly half of the patients recovered after 5 years of disease duration. A high UAS7 at admission seemed to be a significant risk factor for the persistence of symptoms.

  10. A Generalized Decision Framework Using Multi-objective Optimization for Water Resources Planning

    Science.gov (United States)

    Basdekas, L.; Stewart, N.; Triana, E.

    2013-12-01

    Colorado Springs Utilities (CSU) is currently engaged in an Integrated Water Resource Plan (IWRP) to address the complex planning scenarios, across multiple time scales, currently faced by CSU. The modeling framework developed for the IWRP uses a flexible data-centered Decision Support System (DSS) with a MODSIM-based modeling system to represent the operation of the current CSU raw water system coupled with a state-of-the-art multi-objective optimization algorithm. Three basic components are required for the framework, which can be implemented for planning horizons ranging from seasonal to interdecadal. First, a water resources system model is required that is capable of reasonable system simulation to resolve performance metrics at the appropriate temporal and spatial scales of interest. The system model should be an existing simulation model, or one developed during the planning process with stakeholders, so that 'buy-in' has already been achieved. Second, a hydrologic scenario tool(s) capable of generating a range of plausible inflows for the planning period of interest is required. This may include paleo informed or climate change informed sequences. Third, a multi-objective optimization model that can be wrapped around the system simulation model is required. The new generation of multi-objective optimization models do not require parameterization which greatly reduces problem complexity. Bridging the gap between research and practice will be evident as we use a case study from CSU's planning process to demonstrate this framework with specific competing water management objectives. Careful formulation of objective functions, choice of decision variables, and system constraints will be discussed. Rather than treating results as theoretically Pareto optimal in a planning process, we use the powerful multi-objective optimization models as tools to more efficiently and effectively move out of the inferior decision space. The use of this framework will help CSU

  11. A 21-35 kDa Mixed Protein Component from Helicobacter pylori Activates Mast Cells Effectively in Chronic Spontaneous Urticaria.

    Science.gov (United States)

    Tan, Ran-Jing; Sun, He-Qiang; Zhang, Wei; Yuan, Han-Mei; Li, Bin; Yan, Hong-Tao; Lan, Chun-Hui; Yang, Jun; Zhao, Zhuo; Wu, Jin-Jin; Wu, Chao

    2016-12-01

    Helicobacter pylori (H. pylori) seem to involve in the etiology of chronic spontaneous urticaria (CSU). But studies of the pathogenic mechanism are very little. In this study, we detected the serum-specific anti-H. pylori IgG and IgE antibodies in 211 CSU and 137 normal subjects by enzyme-linked immunosorbent assay (ELISA), evaluated the direct activation effects of H. pylori preparations and its protein components on human LAD2 mast cell line in vitro, and analyzed the specific protein ingredients and functions of the most effective H. pylori mixed protein component using liquid chromatography-mass spectrometry and ELISA assay. In CSU patients, the positive rate of anti-H. pylori IgG positive rate was significantly higher than that in normal controls, and the anti-H. pylori IgE levels had no statistical difference between H. pylori-infected patients with and without CSU. Further studies suggested that H. pylori preparations can directly activate human LAD2 mast cell line in a dose-dependent manner and its most powerful protein component was a mixture of 21-35 kDa proteins. Moreover, the 21-35 kDa mixed protein component mainly contained 23 kinds of proteins, which can stimulate the release of histamine, TNF-a, IL-3, IFN-γ, and LTB4 by LAD2 cells in a dose-dependent or time-dependent manner. A 21-35 kDa mixed protein component should be regarded as the most promising pathogenic factor contributing to the CSU associated with H. pylori infection. © 2016 John Wiley & Sons Ltd.

  12. D-Dimer Plasma Levels Parallel the Clinical Response to Omalizumab in Patients with Severe Chronic Spontaneous Urticaria.

    Science.gov (United States)

    Asero, Riccardo; Marzano, Angelo V; Ferrucci, Silvia; Cugno, Massimo

    2017-01-01

    Omalizumab is very effective in the majority of patients with severe chronic spontaneous urticaria (CSU), but its mechanism of action is still unclear. In CSU the coagulation cascade is activated with an intensity that parallels the disease severity, and elevated plasma D-dimer levels are associated with a poor response to both antihistamines and cyclosporin. We measured D-dimer plasma levels before and after the first administration of omalizumab in 32 patients with severe CSU. A number of clinical and laboratory parameters were recorded, including the urticaria activity score, presence of angioedema, disease duration, C-reactive protein, anti-nuclear, and anti-thyroid antibodies. Baseline D-dimer levels were elevated in 19 (59%) cases. Omalizumab induced a complete response in 25 patients (78%), in most cases already after the first administration. At baseline, 14/25 responders had increased D-dimer plasma levels versus 5/7 non-responders. All responders showed a dramatic decrease of D-dimer plasma levels after the first administration of the drug (from 1,024 ± 248 [mean ± SE] to 251 ± 30 ng/mL; p = 0.003). In contrast, non-responders did not show any reduction in D-dimer levels after omalizumab administration (from 787 ± 206 to 1,230 ± 429 ng/mL; p = ns). In conclusion, plasma levels of D-dimer are frequently elevated in patients with severe CSU before omalizumab administration and decrease according to the clinical response of the disease to the drug, suggesting a possible effect of omalizumab on coagulation activation and fibrin degradation in a subset of CSU patients. © 2017 S. Karger AG, Basel.

  13. Clinical and etiologic evaluation of the children with chronic urticaria.

    Science.gov (United States)

    Azkur, Dilek; Civelek, Ersoy; Toyran, Mge; Msrlolu, Emine Dibek; Erkoolu, Mustafa; Kaya, Ayenur; Vezir, Emine; Gini, Tayfur; Akan, Ayegl; Kocaba, Can Naci

    2016-11-01

    Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). To evaluate the clinical features, possible causes, associated findings, and laboratory results of different subtypes of CU in children according to a new classification. In this study, we evaluated the clinical features, laboratory investigations, and provocation tests of children with different subtypes of CU according to a new classification. Two hundred and twenty-two children (59.9% girls) were enrolled in the study. Of the study patients, 59.9% and 40.1% were diagnosed as having CSU and CIndU, respectively. Antithyroid antibody levels were positive in 7.1% of the patients with CSU, 32.8% of the children had positive 14C-urea breath test results, and 6.5% of the patients had positive stool examination results for parasites. Autologous serum skin test results were positive in 53.5% of the patients with CSU. Of the patients with CIndU, 77.5% had symptomatic dermographism, 16.8% had cold urticaria, 2.2% had cholinergic urticaria, 2.2% had solar urticaria, and 1.1% had aquagenic urticaria. Children with CSU represent the majority of patients with CU, and more than a half of these patients might have autoimmune urticaria. Symptomatic dermographism was the most common type of CIndU.

  14. Profile of omalizumab in the treatment of chronic spontaneous urticaria

    Directory of Open Access Journals (Sweden)

    Labrador-Horrillo M

    2015-08-01

    Full Text Available Moises Labrador-Horrillo,1 Marta Ferrer2 1Allergy Section, Internal Medicine Department, Vall d’Hebron Hospital, Universitat Autònoma de Barcelona, Barcelona, 2Department of Allergy and Clinical Immunology, Clínica Universidad de Navarra, IDISNA, Instituto de Investigación de Navarra, Pamplona, Spain Abstract: Chronic spontaneous urticaria (CSU is a disease with significant morbidity and relative prevalence that has important effects on the quality of life (QoL of those who suffer from it. Omalizumab is a recombinant humanized anti-immunoglobulin E (IgE antibody that binds to the Cε3 domain of the IgE heavy chain and prevents it from binding to its high-affinity receptor FcεRI. It has been largely studied in the field of asthma and is currently approved for the treatment of both adult and pediatric (children; >6-year-old patients. In addition, in recent, well-controlled clinical trials in patients with CSU resistant to antihistamines, add-on therapy with subcutaneous omalizumab significantly reduced the severity of itching, and the number and size of hives, and increased patients’ health-related QoL and the proportion of days free from angioedema compared with placebo, with an excellent tolerance. Thus, omalizumab is an effective and well-tolerated add-on therapy for patients with CSU who are symptomatic despite background therapy with H1 antihistamines. In this review, we cover the following points: epidemiology, pathogenesis, assessment of activity, impact on QoL, and treatment of CSU, and finally, we focus on omalizumab in the treatment of CSU including the pharmacokinetic properties and mechanism of action, and use in pregnant women, nursing infants, and children. Keywords: omalizumab, chronic spontaneous urticaria, antihistamines, subcutaneous administration, add-on therapy

  15. Autologous serum skin test response in chronic spontaneous urticaria and respiratory diseases and its relationship with serum interleukin-18 level.

    Science.gov (United States)

    Kurt, Emel; Aktas, Ayse; Aksu, Kurtulus; Keren, Metin; Dokumacioglu, Ali; Goss, Christopher H; Alatas, Ozkan

    2011-11-01

    Autologous serum skin test (ASST) is mostly used in chronic spontaneous urticaria (CSU) to show autoreactivity. Interleukin-18 (IL-18) has also been shown to be involved in autoimmune conditions. To investigate the role of autoreactivity assessed by ASST in CSU and respiratory diseases and to investigate whether this autoreactive state is related to IL-18 level or other clinical covariates. Fifty-five patients with CSU (mean age: 40.3 ± 12.3 years), 70 patients with persistent asthma (mean age: 43.7 ± 9.6 years), 21 patients with seasonal allergic rhinitis (SAR) (mean age: 35.5 ± 11.8 years) and 20 normal controls (mean age: 37.7 ± 9.8) were included. All subjects underwent a laboratory examination and skin prick test. ASST was performed and serum IL-18 levels were measured in all subjects. Positive response to ASST and serum IL-18 levels were higher in CSU patients than those with respiratory diseases (asthma and SAR) (P = 0.034 and 0.002, respectively) and normal controls (P = 0.004 and 0.031, respectively). Considering all patients, IL-18 levels were higher in patients with positive ASST (301.8 ± 194.4 vs. 241.8 ± 206.3 pg/ml, P = 0.036) than ASST negative patients. ASST response was associated with disease severity in CSU (P = 0.037) and asthma patients (P = 0.001). Multivariate analysis showed that positive response to ASST was significantly associated with diagnosis of CSU (OR: 3.13, 95% CI: 1.25-7.87) and female gender (OR: 3.98, 95% CI: 1.19-13.38). ASST response could be related with activity of the disease. A positive ASST response found in respiratory diseases patients suggests that it may occur as a result of some inflammatory events during the diseases' process.

  16. Cloning and Characterization of Ty3/gypsy Retrotransposon in Chilo suppressalis (Lepidoptera:Pyralidae)%二化螟 Ty3/gypsy 反转座子的克隆与序列分析

    Institute of Scientific and Technical Information of China (English)

    李晓欢; 罗光华; 张志春; 刘宝生; 方继朝

    2014-01-01

    Transposable elements constitute a substantial fraction of host genomes.Ty3/gypsy retrotransposon,one group of LTR retrotransposons,is widespread in different species.By inverse-PCR and genome walking,a novel member of Ty3/gypsy retrotransposons was cloned from Chilo suppressalis .This new member of Ty3/gypsy retrotransposons was named Csu-Ty3 (GenBank accession No.KJ1 9 126 1 ).The sequence is 4 934 bp in length and integrated into the “AACGT”target site duplications (TSDs)of the genome.There is a pair of non-completely identical long terminal repeats (LTRs)in the Csu-Ty3 retrotransposon.The 5′LTR is 1 6 1 bp in length and the 3′LTR is 1 68 bp,sharing 93•5 % similarities.A polypurine tract (PPT),1 5 bp in length,is adjacent to the 3′LTR.There are three independent open reading frames (ORFs)in Csu-Ty3.The first ORF encodes a protein which is related to viral structural protein,termed GAG.The second encodes aspartic protease (AP).The third encodes a polyprotein including a reverse transcriptase (RT)which produces a cDNA copy of the transposon′s RNA,an RNase H (RH)which splits the DNA-RNA hybrid and an integrase (IN ) which inserts the cDNA into the host′s genome.The southern hybridization indicated that there were many Csu-Ty3 copies in different C .suppressalis populations.Flanking PCR results showed that the Csu-Ty3 copy was inserted at the same locus in different populations.At this locus,all the individuals have the Csu-Ty3 copy insertion except some individuals from Deyang and Jiangjin populations.The Csu-Ty3 insertion ratio varied with field populations.%转座子是宿主基因组的重要组成部分.Ty3/gypsy 反转座子是广泛存在于生物体内的一类反转座子.通过反向PCR(inverse PCR)和基因组步移方法成功地从二化螟体内获得一个具有完整结构的 Ty3/gypsy 反转座子拷贝,命名为Csu-Ty3(GenBank 登录号:KJ191261).该反转座子拷贝全长4934 bp,在基因组上插入的靶位点(target sit

  17. Sandia`s computer support units: The first three years

    Energy Technology Data Exchange (ETDEWEB)

    Harris, R.N. [Sandia National Labs., Albuquerque, NM (United States). Labs. Computing Dept.

    1997-11-01

    This paper describes the method by which Sandia National Laboratories has deployed information technology to the line organizations and to the desktop as part of the integrated information services organization under the direction of the Chief Information officer. This deployment has been done by the Computer Support Unit (CSU) Department. The CSU approach is based on the principle of providing local customer service with a corporate perspective. Success required an approach that was both customer compelled at times and market or corporate focused in most cases. Above all, a complete solution was required that included a comprehensive method of technology choices and development, process development, technology implementation, and support. It is the authors hope that this information will be useful in the development of a customer-focused business strategy for information technology deployment and support. Descriptions of current status reflect the status as of May 1997.

  18. CALIFORNIA STATE UNIVERSITY CATASTROPHIC (CAT) LEAVE DONATION PROGRAM: DEMOGRAPHICS, ECONOMIC SECURITY, AND SOCIAL EQUITY.

    Science.gov (United States)

    Muller, Christina

    2015-01-01

    The California State University (CSU) Chancellor's Office reached an agreement with all CSU collective bargaining units and Employee Relations on a uniform Catastrophic (CAT) Leave Donation Program in 1992. The CAT Leave Donation Program allows employees to donate sick and/or vacation leave credits to employees who are incapacitated due to a catastrophic illness or injury and have exhausted all of their own leave credits. This also extends to employees with whom family illnesses are deemed catastrophic, thus requiring the employee to care for an immediate family member. Stakeholders include union represented employees who accrue leave credits as well as any employee who receives or donates hours of leave credits in the program. Other stakeholders include the family members and program administrators.

  19. Rheological properties of crude oils in Yaregskoye and Yaraktinskoye oil fields

    Science.gov (United States)

    Manzhai, V. N.; Le Grand Monkam Monkam, Clovis; Terre, D. A.

    2016-09-01

    Rotary viscometer tests of crude oil with a high content of resins and asphaltenes (Yaregskoye oil field) and crude oil with high paraffin content (Yaraktinskoye oil field) have been conducted. The typical flow curves for these oil types have been plotted. It has been detected that these oils are non-Newtonian fluids, viscosity of which is dependent on shear rate. Based on Arrhenius-Eyring equation, calculations of viscous flow activation energy and complex structural unit (CSU) sizes have been performed. It has been stated that there is a tenfold reduction in CSU size in asphaltic crude oil with the increase in shear rate in a rotary viscometer, while particle size in paraffinic crude oil does not essentially change under the same hydrodynamic conditions.

  20. Fullerton Virtual Twin Study.

    Science.gov (United States)

    Segal, Nancy L

    2006-12-01

    Virtual twins (VTs; same-age unrelated siblings reared together from early infancy) have been studied at California State University (CSU), Fullerton since 1991. The current sample includes over 130 pairs. Past and current research have research have focused on siblings' similarities and differences in general intelligence and body size. Future research in these areas will continue as new pairs continue to be identified. These studies will be supplemented by analyses of personality, social relations and adjustment using monozygotic (MZ) twins, dizygotic (DZ) twins, full siblings and friends, as well as new VTs, who have participated in Twins, Adoptees, Peers and Siblings (TAPS), a collaborative project conducted between CSU Fullerton and the University of San Francisco, from 2002 to 2006.

  1. Omalizumab in Children

    OpenAIRE

    Licari, Amelia; Marseglia, Alessia; Caimmi, Silvia; Castagnoli, Riccardo; Foiadelli, Thomas; Barberi, Salvatore; Marseglia, Gian Luigi

    2014-01-01

    Omalizumab is a recombinant humanized monoclonal antibody that reduces levels of circulating immunoglobulin E (IgE) and expression of IgE high-affinity receptors on mast cells and basophils, interrupting the subsequent allergic inflammatory cascade. Current indications for treatment with omalizumab in pediatric patients are clearly defined and are confined to moderate-to-severe uncontrolled allergic asthma and chronic spontaneous urticaria (CSU). Any other prescription can only be off label. ...

  2. Overview of NASA Multi-dimensional Stirling Convertor Code Development and Validation Effort

    Science.gov (United States)

    Tew, Roy C.; Cairelli, James E.; Ibrahim, Mounir B.; Simon, Terrence W.; Gedeon, David

    2002-01-01

    A NASA grant has been awarded to Cleveland State University (CSU) to develop a multi-dimensional (multi-D) Stirling computer code with the goals of improving loss predictions and identifying component areas for improvements. The University of Minnesota (UMN) and Gedeon Associates are teamed with CSU. Development of test rigs at UMN and CSU and validation of the code against test data are part of the effort. The one-dimensional (1-D) Stirling codes used for design and performance prediction do not rigorously model regions of the working space where abrupt changes in flow area occur (such as manifolds and other transitions between components). Certain hardware experiences have demonstrated large performance gains by varying manifolds and heat exchanger designs to improve flow distributions in the heat exchangers. 1-D codes were not able to predict these performance gains. An accurate multi-D code should improve understanding of the effects of area changes along the main flow axis, sensitivity of performance to slight changes in internal geometry, and, in general, the understanding of various internal thermodynamic losses. The commercial CFD-ACE code has been chosen for development of the multi-D code. This 2-D/3-D code has highly developed pre- and post-processors, and moving boundary capability. Preliminary attempts at validation of CFD-ACE models of MIT gas spring and "two space" test rigs were encouraging. Also, CSU's simulations of the UMN oscillating-flow fig compare well with flow visualization results from UMN. A complementary Department of Energy (DOE) Regenerator Research effort is aiding in development of regenerator matrix models that will be used in the multi-D Stirling code. This paper reports on the progress and challenges of this

  3. Initial experimental results of a machine learning-based temperature control system for an RF gun

    CERN Document Server

    Edelen, A L; Milton, S V; Chase, B E; Crawford, D J; Eddy, N; Edstrom, D; Harms, E R; Ruan, J; Santucci, J K; Stabile, P

    2015-01-01

    Colorado State University (CSU) and Fermi National Accelerator Laboratory (Fermilab) have been developing a control system to regulate the resonant frequency of an RF electron gun. As part of this effort, we present initial test results for a benchmark temperature controller that combines a machine learning-based model and a predictive control algorithm. This is part of an on-going effort to develop adaptive, machine learning-based tools specifically to address control challenges found in particle accelerator systems.

  4. EQ-5D Utilities in Chronic Spontaneous/Idiopathic Urticaria.

    Science.gov (United States)

    Hawe, Emma; McBride, Doreen; Balp, Maria-Magdalena; Tian, Haijun; Halliday, Anna; Stull, Donald E

    2016-05-01

    To obtain utility estimates suitable for use in economic models for chronic spontaneous (idiopathic) urticaria (CSU). Patient-level data from three randomized clinical trials-ASTERIA I, ASTERIA II and GLACIAL-were analysed. Health states were derived from the Urticaria Activity Score over 7 days (UAS7); higher scores denote greater activity. The health state score ranges were urticaria free: 0; well-controlled urticaria: 1-6; mild urticaria: 7-15; moderate urticaria: 16-27; and severe urticaria: 28-42. The mean EQ-5D utilities were calculated for each health state. A mixed model was used to predict the EQ-5D according to UAS7 health states in a pooled data set containing all treatment arms and time points from the three trials. Pooled trial data were validated through visual comparisons and interaction terms. Fixed and random effects for trials and patients were included, along with the following covariates: UAS7 health state at baseline (moderate or severe); presence of angioedema at baseline and during follow-up; duration of CSU; number of previous CSU medications; visit; current treatment; and patient age and sex. There was a consistent improvement in EQ-5D utilities as urticaria activity decreased. The mean utilities ranged from 0.710 (severe urticaria) to 0.780 (moderate urticaria), 0.829 (mild urticaria), 0.862 (well-controlled urticaria) and 0.894 (urticaria free). Sensitivity and subgroup analyses confirmed the robustness of the results. The results suggest that EQ-5D utility scores increase with decreasing urticaria activity. EQ-5D utility scores enable the health-related quality of life of CSU patients to be compared with that of patients with other diseases.

  5. Overview of NASA Multi-Dimensional Stirling Convertor Code Development and Validation Effort

    Science.gov (United States)

    Tew, Roy C.; Cairelli, James E.; Ibrahim, Mounir B.; Simon, Terrence W.; Gedeon, David

    2003-01-01

    A NASA grant has been awarded to Cleveland State University (CSU) to develop a multi-dimensional (multi-D) Stirling computer code with the goals of improving loss predictions and identifying component areas for improvements. The University of Minnesota (UMN) and Gedeon Associates are teamed with CSU. Development of test rigs at UMN and CSU and validation of the code against test data are part of the effort. The one-dimensional (1-D) Stirling codes used for design and performance prediction do not rigorously model regions of the working space where abrupt changes in flow area occur (such as manifolds and other transitions between components). Certain hardware experiences have demonstrated large performance gains by varying manifolds and heat exchanger designs to improve flow distributions in the heat exchangers. 1-D codes were not able to predict these performance gains. An accurate multi-D code should improve understanding of the effects of area changes along the main flow axis, sensitivity of performance to slight changes in internal geometry, and, in general, the understanding of various internal thermodynamic losses. The commercial CFD-ACE code has been chosen for development of the multi-D code. This 2-D/3-D code has highly developed pre- and post-processors, and moving boundary capability. Preliminary attempts at validation of CFD-ACE models of MIT gas spring and ``two space'' test rigs were encouraging. Also, CSU's simulations of the UMN oscillating-flow rig compare well with flow visualization results from UMN. A complementary Department of Energy (DOE) Regenerator Research effort is aiding in development of regenerator matrix models that will be used in the multi-D Stirling code. This paper reports on the progress and challenges of this multi-D code development effort.

  6. Worldwide Report, Arms Control.

    Science.gov (United States)

    2007-11-02

    DIE WELT Editorial, by Horst-Alexander Siebert 11 FRG’s Ruehe Discusses SDI Negotiations With U.S. ( Volker Ruehe Interview; Hamburg DER SPIEGEL, 23...warns about the pernicious consequences of the Pentagon’s militarization of space. As the newspaper THE GUARDIAN reports, he branded "Star Wars" as a...21-24 [Interview with CDU/CSU Group Chairman Deputy Volker Ruehe by unidentified SPIEGEL editor; date not given] [Text] SPIEGEL: Mr Ruehe, how do

  7. Serum Clusterin as a Prognostic Marker of Chronic Spontaneous Urticaria.

    Science.gov (United States)

    Kim, Ji-Hye; Lee, Hyung-Young; Ban, Ga-Young; Shin, Yoo-Seob; Park, Hae-Sim; Ye, Young-Min

    2016-05-01

    A substantial proportion of patients with chronic spontaneous urticaria (CSU) are refractory to antihistamines. However, identifying the subpopulation whose urticaria is not completely controlled by antihistamines remains difficult. The response of autologous serum skin test (ASST), a clinical test for the detection of basophil histamine-releasing activity upon autoantibodies or autoreactive stimulation, has been suggested as a potential predictor in the control of urticaria. We sought to identify proteins that were differentially expressed in the sera of patients with positive and negative ASST results and to investigate their association with urticaria control.Proteomics analysis was performed using sera from 3 CSU patients with positive ASST results compared with those showing negative ASST results. Seven upregulated and 5 downregulated proteins were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in the ASST-positive group compared with the ASST-negative group.Proteins that were differentially expressed according to the ASST results in CSU patients were classified into 6 groups: apolipoproteins, glycoproteins, modified albumin, haptoglobulin, plectin, and others. Among these, apolipoprotein J or clusterin was validated using an enzyme-linked immunosorbent assay. Clusterin levels in 69 ASST-positive patients were significantly higher than those in 69 ASST-negative patients and in 86 healthy controls (231.2 ± 44.0 vs 210.2 ± 36.1 vs 118.7 ± 71.9 μg/mL, P urticaria would be refractory to antihistamines. Serum clusterin can be a prognostic marker to determine the responsiveness to antihistamine treatment in patients with CSU.

  8. Crisis del sistema de gobierno en las universidades públicas colombianas. Aportes a una sociología del poder en las universidades

    Directory of Open Access Journals (Sweden)

    Víctor Manuel Gómez Campo

    2012-01-01

    Full Text Available Uno de los grandes temas en la sociología de la educación superior es la ‘sociología del poder’ en las instituciones, cuya principal expresión es el gobierno institucional, entendido como el conjunto de normas que definen y regulan tanto los órganos de toma de decisiones y su relación jerárquica, como la participación y representación de diversos grupos, estamentos y sectores de la sociedad en dichos órganos. Dado que en las universidades públicas colombianas el principal órgano de gobierno es el Consejo Superior Universitario (CSU, reglado en la Ley 30 de 1992, se define como un importante objeto de estudio sociológico la composición del CSU, el origen de sus miembros y sus respectivas filiaciones, lealtades y grupos o sectores sociales que representa. Este análisis permite comprender la naturaleza democrática de la composición del CSU, el alcance y los límites de la representatividad de sus miembros, así como la legitimidad de las decisiones que este órgano supremo de gobierno toma, todo lo cual configura las posibilidades y los límites de la ‘democracia universitaria’.

  9. Colorado State University: A Midscale Market Solar Customer Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Holm, Alison [National Renewable Energy Lab. (NREL), Golden, CO (United States); Chernyakhovskiy, Ilya [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-12-01

    Despite substantial increases in solar photovoltaic (PV) deployment between 2005 and 2015, a large untapped market for solar PV deployment still exists in midscale market investments by universities. Recent estimates show that if all universities in the United States installed enough solar PV to meet 25% of their annual electricity consumption, this would cumulatively result in just over 16 gigawatts (GW) of additional installed PV capacity. Within this context, midscale market projects - loosely defined as solar PV installations ranging from 100 kilowatts (kW) to 2 megawatts (MW), but more broadly representing installations not captured in the residential or utility-scale sectors - could be an attractive option for universities. This case study focuses on one university solar customer, Colorado State University (CSU), to provide a detailed example of the challenges, solutions, and opportunities associated with university solar power procurement. Between 2009 and 2015, a combined 6,754 kW of both ground-mounted and rooftop solar PV was installed across multiple CSU campuses in Fort Collins, Colorado. This case study highlights CSU's decision-making process, campus engagement strategies, and relationships with state, local, and utility partners, which have culminated in significant on-campus PV deployment.

  10. Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria

    Directory of Open Access Journals (Sweden)

    Aysegul Alpay

    2013-01-01

    Full Text Available Previous studies indicate that 25–45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST and autologous plasma skin test (APST are simple tests for diagnosing chronic autoimmune urticaria (CAU. However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU and 50 sex- and age-matched healthy individuals aged 18 years, and older. A total of 31 (62% patients and 5 (10% control patients had positive ASST; 21 (42% patients and 3 (6% control patients had positive APST. Statistically significant differences were noted in ASST and APST positivity between the patient and control groups (ASST P<0.001; APST P<0.001. Thirteen (26% patients and 5 (10% control patients had antithyroglobulin antibodies or antithyroid peroxidase antibody positivity. No statistically significant differences were noted in thyroid autoantibodies between the patient and control groups (anti-TG P=0.317; anti-TPO P=0.269. We consider that the ASST and APST can both be used as in vivo tests for the assessment of autoimmunity in the etiology of CSU and that thyroid autoantibodies should be checked even when thyroid function tests reveal normal results in patients with CSU.

  11. Investigation of thiol-disulphide balance in patients with acute urticaria and chronic spontaneous urticaria.

    Science.gov (United States)

    Akbas, Ayse; Kilinc, Fadime; Sener, Sertac; Aktaş, Akın; Baran, Pervin; Ergin, Merve

    2017-09-01

    Thiol-disulphide balance plays a major role in health and diseases. This balance may be disrupted by various diseases. We aimed to determine status of the effect of thiol-disulphide balance in urticaria. We aimed to investigate the thiol-disulphide balance in patients with acute urticaria (AUP) and chronic spontaneous urticaria (CSU). Study included 53 AUP and 47 healthy controls plus 57 patients with chronic spontaneous urticaria (CSUP) and 57 healthy controls. Levels of native thiols, disulphides and total thiols were evaluated in plasma using a new and automated spectrophotometric method. Ratios of disulphides/total thiols, disulphides/native thiols and native thiols/total thiols were calculated. For AU, there was no statistical difference compared to control group in levels of native thiols, disulphides and total thiols. For CSU, however, there was an increase in levels of native thiols, disulphides and total thiols and the ratio of thiol/disulphide in favour of disulphide. Thiol-disulphide balance was not affected by AU but shifted towards to disulphide in CSU indicating the presence of oxidative stress (OS).

  12. Polarimetric and Multi-Doppler Radar Observations of Sprite-producing Storms

    Science.gov (United States)

    Lang, TImothy J.; Lyons, Walter A.; Rutledge, Steven A.; Dolan, Brenda; Cummer, Steven A.; Krehbiel, Paul; Rison, William

    2014-01-01

    Sprites are caused by luminous electrical breakdown of the upper atmosphere, and frequently occur over large mesoscale precipitation systems. Two sprite-producing storms (on 8 and 25 June) were observed in Colorado during the summer of 2012. Unlike most past studies of sprites, these storms were observed by a polarimetric radar - the CSU-CHILL facility - which provided both PPI and RHI scans of the cases. Also available were multiple-Doppler syntheses from CSU-CHILL, local NEXRAD radars, and the CSU-Pawnee radar; as well as data from the Colorado Lightning Mapping Array (COLMA), high speed cameras, and other lightning-detection instrumentation. This unique dataset provided an unprecedented look at the detailed kinematic and microphysical structures of the thunderstorms as they produced sprites, including electrical alignment signatures in the immediate location of the charge layers neutralized by sprite-parent positive cloud-to-ground lightning strokes. One of the sprite-producing cases (25 June) featured an anomalous charge structure and may serve as a model for how sprites can be produced over convection rather than the more typical stratiform regions. Also to be presented will be evidence for advection of charge into a common stratiform precipitation region (on 8 June), which was then tapped by lightning originating from multiple different convective cores to produce sprites. Depending on the outcome of the 2013 convective season, polarimetric data from additional storms that produce sprites and other transient luminous events (TLEs) may be presented.

  13. Dynamic Steering Control of Battery Operated Car for Lane Keeping using Image Sensor

    Directory of Open Access Journals (Sweden)

    Ankit Sharma

    2011-01-01

    Full Text Available This project presents simple prototype for driving automation of battery operated cars. The system consists of Decision Making Unit (DMU & Control System Unit (CSU to implement decision given by DMU. DMU performs the task of image acquisition, enhancing, thresholding, noise reduction, calculation of the position of car with respect to lanes and estimation of the desired position. DMU communicate with CSU using UART serial protocol, thereby informing CSU to take necessary control action regarding - speed control & position control of steering wheel. Speed control is an open loop system which controls the two DC motors powering the front wheels of car. Mechanical hardware for position control of steering wheel contains a high torque DC motor which is coupled to steering wheel using gears in mesh configuration. The control algorithm used here is digital PID algorithm. The PID is digitized using trapezoidal approximation, Newton’s backward difference method to approximate integration & differentiation. Feedback signal is generated by 47kΩ potentiometer which gives a output of 0-5 volt. The algorithm based on these methods has been programmed in the Atmega16 which drives the dc motor coupled with steering wheel using L293d motor driver.

  14. Autologous serum skin test as an indicator of chronic autoimmune urticaria in a tertiary care hospital in South India

    Directory of Open Access Journals (Sweden)

    Adaikalampillai Ganapathy Vikramkumar

    2014-01-01

    Full Text Available Background: Autologous serum skin test (ASST is a simple in-vivo clinical test for the detection of basophil histamine releasing activity and to diagnose chronic autoimmune urticaria (CAU among chronic spontaneous urticaria (CSU patients. Diagnosing these patients is also important as they may need high doses of antihistamines and systemic corticosteroids during acute exacerbations. Aims and Objectives: The aim of this study is to study the prevalence of CAU among cases of CSU by using ASST. Materials and Methods: This was a cross-sectional study done among 48 patients presenting with CSU. Detailed history, physical examination and routine investigations were recorded for all patients. ASST was done on all the 48 patients. Results: Of the 48 patients included in the study, 20 patients (41.6% were ASST positive, while the remaining 28 (58% were ASST negative. The median duration of disease in both ASST positive and negative patients was 1 year. ASST positivity was higher (66.6% among patients with a history of round shaped weals, though not statistically significant. ASST positivity was seen in 5 (71.4% out of seven patients with systemic involvement, which was again not statistically significant. Conclusion: Our study did not show any significant difference between patients with and without antibodies regarding mean age and sex distribution, clinical morphology of individual weals, duration, severity, systemic symptoms, angioedema, atopy, and association with other autoimmune conditions.

  15. Res-E Support Policies in the Baltic States: Electricity Price Aspect (Part II)

    Science.gov (United States)

    Bobinaite, V.; Priedite, I.

    2015-04-01

    Increasing volumes of electricity derived from renewable energy sources (RES-E) affect the electricity market prices and the prices for final electricity consumers in the Baltic States. The results of a multivariate regression analysis show that in 2013 the RES-E contributed to decreasing the electricity market prices in the Baltic States. However, the final electricity consumers pay for the promotion of RES-E through the approved RES-E component which has a tendency to increase. It is estimated that in 2013 the net benefits from the wind electricity promotion were achieved in Lithuania and Latvia while the net cost - in Estonia. This suggests that the economic efficiency of the wind electricity support scheme based on the application of feed-in tariffs was higher than that based on the feed-in premium. Rakstā analizēta elektroenerģijas ražošanas no atjaunojamiem energoresursiem (AER-E) palielināšanas ietekme uz elektroenerģijas tirgus cenu un gala cenu elektroenerģijas lietotājiem Baltijas valstīs. Daudzfaktoru regresijas analīzes rezultāti atklāja, ka AER-E 2013. gadā varētu samazināt elektroenerģijas tirgus cenas Baltijas valstīs. Tomēr jāņem vērā, ka elektroenerģijas lietotāja gala cenā ir iekļauta AER-E atbalsta komponente, kurai ir raksturīgi palielināties. Aprēķināts, ka no vēja elektroenerģijas ražošanas Latvijā un Lietuvā tika iegūta tīrā peļņa, bet Igaunijā tikai nosedza pašizmaksu. Tas liecina, ka vēja elektroenerģijas atbalsta shēmai, kas balstīta uz obligātā iepirkuma atbalsta principu, ir augstāka ekonomiskā efektivitāte, nekā atbalsta shēmai, kas balstīta uz piemaksu par no AER saražoto elektroenerģiju obligātā iepirkuma ietvaros.

  16. Comparative study of positive versus negative autologous serum skin test in chronic spontaneous urticaria and its treatment outcome

    Directory of Open Access Journals (Sweden)

    Yadalla Hari Kishan Kumar

    2016-01-01

    Full Text Available Background: Chronic urticaria (CU is defined as urticaria persisting daily or almost daily for more than 6 weeks and affecting 0.1% of the population. Mast cell degranulation and histamine release are of central importance in the pathogenesis of CU. About 40-50% of the patients with chronic idiopathic urticaria (CIU or chronic spontaneous urticaria (CSU demonstrates an immediate wheal and flare response to intradermal injected autologous serum. This led to the concept of autoimmune urticaria (AIU. Aims: To determine the occurrence, clinical features, associated clinical conditions, comorbidities of AIU, and to compare this with CSU. This study aimed to find the frequency of autologous serum skin test (ASST-positive patients among patients with CSU and to identify the clinical and laboratory parameters associated with positive ASST and to compare the treatment outcome. Materials and Methods: A prospective correlation study in 110 patients with CSU was conducted, after screening 200 CU patients attending the outpatient Department of Dermatology during from January 2012 to May 2013. Patients were subjected to ASST, complete blood counts, urine routine examination, liver function tests, renal function tests, thyroid function tests (T3, T4, and TSH, and urine analysis. Results: Out of 200 CU patients screened, 90 patients had excludable causes based on detailed history and skin prick test, and the remaining 110 patients were considered to have CSU. These 110 patients were further subjected to ASST, serum immunoglobulin E (IgE, and peripheral blood eosinophilia. ASST was positive in 48 patients and negative in 62 patients. Frequency of urticarial attacks and associated diseases such as abnormal thyroid function tests in both ASST-positive and ASST-negative patients did not show any statistical significance. Only attacks of angioedema in ASST-positive individuals were higher and were statistically significant. In the ASST-positive group, 31 (81

  17. Mājmācība kā alternatīvs izglītības ieguves veids bērniem

    OpenAIRE

    Kokina, Laine Marija

    2014-01-01

    Bakalaura darbs „Mājmācība kā altneratīvs izglītības ieguves veids bērniem” ir pētījums par mājmācības kustību Latvijā, ietverot tajā ģimeņu prakses mācot bērnus mājās, kā arī pievēršoties skolas un valsts lomai mājskološanas kontekstā. Šobrīd Latvijā mājmācības kustība ir salīdzinoši jauna un tikai pēdējos gadus aiz vien aktīvāk tiek runāts par bērnu mācīšanu mājās kā alternatīvu izglītības formu. Pētījuma mērķis ir noskaidrot mājmācības iespējas Latvijā un, kāpēc ģimenes izvēlas šadu mod...

  18. Personības iezīmju, vainas atribūcijas un attieksmes pret sodu savstarpējās saistības nosacīti notiesātajiem vīriešiem.

    OpenAIRE

    Gorlanova, Kristīne

    2013-01-01

    Šī pētījuma mērķis ir noskaidrot vai pastāv statistiski nozīmīgas saistības starp nosacīti notiesāto vīriešu personības iezīmēm, vainas izjūtas atribūciju un attieksmi pret sodu. Pētījums tika veikts sadarbībā ar Valsts probācijas dienestu. Izlasē tika iekļauti 57 latviski runājoši nosacīti notiesāti pilngadīgi vīrieši, vecumā no 18 līdz 58 gadiem. Mainīgo mērīšanai tika izmantotas 3 metodes: 1) aptauja „Lielais piecinieks” (The Big Five Inventory; John, Donahue, & Kentle, 1991; Benet-Martí...

  19. Darba tirgus problēmas Latvijā

    OpenAIRE

    Kūka, Zane

    2008-01-01

    Maģistra darba mērķis ir izpētīt faktorus, kas ietekmē darbaspēka tirgu Latvijā un, balstoties uz darbā veikto analīzi, sniegt iespējamos risinājumus darba tirgus problēmu novēršanai. Maģistra darbā tiek veikta teorijas analīze par darba tirgus lomu labklājības paaugstināšanā, un valsts spēju ietekmēt darba tirgu. Tiek analizēti darba tirgus ietekmējošie faktori, tādi kā nodarbinātība, demogrāfiskā situācija un migrācija. Saskaņā ar to, ka darba samaksa ir viens no galvenajiem rādītājiem, ...

  20. Bezdarbs, tā ietekme uz Latvijas tautsaimniecību laika posmā no 2004.-2012.gadam

    OpenAIRE

    Poikāne, Laima

    2012-01-01

    Bezdarbs un tā apmērs konkrētā valstī, reģionā kādā noteiktā laika vienībā ir viens no svarīgākajiem makroekonomiskajiem rādītājiem, jo tas rada virkni nelabvēlīgu ekonomisku un sociālu zaudējumu. Tā kā bezdarba līmenis pēdējo gadu laikā un arī šobrīd ir viena no aktuālākajām problēmām Latvijas sabiedrībai, šajā darbā tika veikta bezdarba ietekmējošo faktoru analīze laika posmā no 2004. – 2012. gadam. Šie faktori tika atlasīti, balstoties gan uz makroekonomikas pētnieku, gan arī uz Latvijas m...

  1. Globalizācija Ķīnā: ekonomiskais, sociālais un politiskais aspekts

    OpenAIRE

    Kotova, Viktorija

    2012-01-01

    Izstrādātā bakalaura darba nosaukums ir „Globalizācija Ķīnā: ekonomiskais, sociālais un politiskais aspekts”. Darba mērķis ir izpētīt, kādā mērā Ķīna ir globalizēta ekonomiskajā, sociālajā un politiskajā jomā. Ņemot vērā to, ka globalizācija ir asimetrisks process, un atsevišķās jomās valsts var būt vairāk globalizēta, nekā citās, tika izvirzīts sekojošs pētnieciskais jautājums - Vai ekonomiskā, sociālā un politiskā globalizācija Ķīnā notiek paralēli vai vienā no jomām Ķīna ir vairāk globaliz...

  2. Parastās egles Picea abies L. ietekme uz mālsmilts augsnes virskārtas īpašībām bijušajās lauksaimniecībā izmantojamā zemē Taurenes apkārtnē

    OpenAIRE

    Ševčuka, Aleksandra

    2016-01-01

    Latvijā, kā arī citās Eiropas valstīs pēc 1990. gada strauji palielinājās pamesto lauksaimniecībā izmantojamo zemju(LIZ) platības. Zemju neapsaimniekošanas dēļ uz bijušajām LIZ attīstījās sekundārā sukcesija un apmežošanas process. Apmežošanas izraisa veģetācijas, mikroklimata un augsnes īpašību izmaiņas uz bijušajām LIZ zemēm. Pētījuma mērķis ir noskaidrot egles (Picea abies L.) ietekmi uz augsnes īpašībām (ķīmiskajām, morfoloģiskajām, fizikālajām) Taurenes apkārtnē, Vidzemē. Bakalaura darbā...

  3. Dzejniece Li Cjindžao (1084. - 1151.) un Sun dinastijas kulūra

    OpenAIRE

    Lapšina, Aelita

    2015-01-01

    Bakalaura darba tēma ir “Dzejniece Li Cjindžao (1084 - 1151) un Sun dinastijas kultūra”. Darbā tiek pētīta Sun dinastijas vēsture un kultūra, svarīgie notikumi un izgudrojumi, attiecības valstī un literatūras nozarē. Viena no pazīstamākajām tā laika personām ir dzejniece Li Cjindžao, par kuru plašāk ir aprakstīts darbā. Mūsdienās, pateicoties vairākām pētniecības programmām, mēs esam iepazinuši Ķīnu no daudzām pusēm, tomēr tik un tā paliek neizpētīti vairāku vēstures momentu un personu vēs...

  4. Bāriņtiesu institūts Latvijā: tiesiskais regulējums un realitāte

    OpenAIRE

    Dzene, Rebeka

    2017-01-01

    Ģimenes institūta analizēšana no privātā un publiskā aspekta ir aktuāla, jo ģimenes institūta neaizskaramības robežas, valsts iejaukšanās apjoma robežas un iejaukšanās pamatotība nav nepārprotami noteikta. Pētījumā iejaukšanās nepieciešamība ģimenes tiesiskajās attiecībās tiek vērtēta no bērnu tiesību un tiesisko interešu aizsardzības viedokļa, to vērtējot no ģimenes tiesību uz privātautonomiju aspekta. Pētījumā tiek analizēta bāriņtiesu loma bērnu tiesību nodrošināšanā un iejaukšanās robežas...

  5. Nekustāmā īpašuma vērtēšanas modeļi

    OpenAIRE

    Novikova, Svetlana

    2015-01-01

    Bakalaura darbs veltīts nekustāmā īpašuma masveida vērtēšanas problemātikai. Bakalaura darbā apskatīti nekustāmā īpašuma masveida vērtēšanas pamatprincipi un vērtēšanā izmantotie modeļu tipi. Darbā apskatīta ratio analīzes metodoloģija, kas tiek izmantota masveida vērtēšanas rezultātu novērtēšanai. Aprakstot spēkā esošo dzīvokļa īpašuma vērtēšanas modeli, ko izmanto Valsts zemes dienests, darbā piedāvāts vērtēt dzīvokļa īpašumu kā vienotu īpašumu, nedalot tās vērtību atsevišķās sastāvdaļa...

  6. Sieviešu vara Osmaņu impērijā 17.-18.gs.

    OpenAIRE

    Krieķis, Jānis

    2017-01-01

    Bakalaura darba tēma ir “Sieviešu vara Osmaņu impērijā 17.-18.gs.” Darba uzdevums ir aplūkot vēsturisko situāciju un procesus Osmaņu impērijā, kas gala rezultātā noveda pie tā dēvētā “Sieviešu sultanāta”. Tas bija periods Osmaņu impērijas vēsturē, kad valsts politiskajos procesos ievērojamu lomu spēlēja tieši sievietes, neskatoties uz šķietami necilu lomu tradicionālajā islāma izpratnē par sievietēm. Darbs sastāv no trim daļām. Pirmajā daļā tiek apskatīts tradicionālais varas modelis un priek...

  7. Latvijas sakari ar Lietuvu un Igauniju mākslas jomā. 1918-1940

    OpenAIRE

    2016-01-01

    Maģistra darba „Latvijas sakari ar Lietuvu un Igauniju mākslas jomā. 1918-1940” mērķis ir izpētīt Latvijas mākslas sakarus ar Lietuvu un Igauniju laikā no 1918. līdz 1940. gadam, iezīmējot to veidošanos, norisi, kā arī galvenās attīstības tendences. Darbā aplūkota valsts iestāžu un sabiedrisko organizāciju loma Latvijas mākslas sakaru ar Lietuvu un Igauniju veidošanā, kā arī sakari tādās jomās kā literatūra, skatuves māksla, mūzika un tēlotāja māksla. Apskatāmajā laika periodā Latvijas māksla...

  8. Latvijas mākslas sakari ar Igauniju un Lietuvu. 1918-1934

    OpenAIRE

    2014-01-01

    Bakalaura darba "Latvijas mākslas sakari ar Igauniju un Lietuvu. 1918-1934" mērķis ir izpētīt Latvijas mākslas sakaru ar Igauniju un Lietuvu izpausmes un galvenās tendences laikā no 1918. līdz 1934.g. Darbā aplūkoti mākslas sakari tādās jomās kā skatuves māksla, mūzika, literatūra un tēlotāja māksla, izvērtējot to atšķirīgo attīstības intensitāti un virzienus. Latvijas mākslas sakari ar Igauniju un Lietuvu apskatāmajā laika periodā strauji attīstījās, veidojot daļu no valsts ārpolitikas...

  9. Vēlīnā romantisma mākslas filozofija.

    OpenAIRE

    Spuldzeniece, Dārta

    2014-01-01

    Darbā ir sniegts ieskats Vēlīnā Romantisma filozofiskajā programmā, analīzē pievēršoties noturīgiem Romantisma motīviem no Agrīnā līdz Vēlīnajam Romantismam. Darba galvenais uzdevums ir izpētīt Romantisma filozofiskās programmas ietekmi uz Vēlīnā Romantisma mākslu un mūziku. Darbā pētītas nozīmīgākās Vēlīnā Romantisma iezīmes: jauni politikas un valsts koncepti, jaunas mitoloģijas praktizēšana, pāreja no poēzijas pie politikas. Lai iegūtu lielāku ieskatu romantisma attīstībā, izpētes pr...

  10. Transnacionālo kompāniju darbība Latvijā

    OpenAIRE

    Eiduks, Roberts

    2013-01-01

    Globalizācijas process ietekmē ne tikai konkurences palielināšanos starp uzņēmumiem, bet arī starp dažādām valstīm. Lai uzņēmumi kļūtu konkurētspējīgāki, tie apvienojas kā rezultātā veidojas dažādas starpvalstu uzņēmumu apvienības. Viena no tām ir transnacionālās korporācijas, kuru loma pasaules ekonomiskajos procesos arvien pieaug. Pētījuma mērķis ir analizēt transnacionālo kompāniju darbību Latvijā. Galvenie uzdevumi ir apskatīt teoriju un praktiski izanalizēt transnacionālās kompānij...

  11. Analysis of the association of chronic spontaneous urticaria with interlekin-4, -10, transforming growth factor-β1, interferon-γ, interleukin-17A and -23 by autologous serum skin test

    Science.gov (United States)

    Kırmaz, Cengiz; Vatansever, Seda; Onur, Ece; Nal, Emine; Erdin, Soner; Ozyurt, Beyhan

    2017-01-01

    Aim To contribute to the understanding of the pathogenesis of chronic spontaneous urticaria (CSU) by identifying its relationship with autoimmunity and cytokines using the autologous serum skin test (ASST) and peripheral blood mononuclear cell culture (PBMC) method. Material and methods Interleukins (IL)-4, IL-10, transforming growth factor (TGF-β1), interferon (IFN)-γ, IL-17A, and IL-23 levels in cell supernatants obtained by the PBMC method were measured using ELISA. Disease activity was assessed by determining the urticaria activity score (UAS). Results A total of 40 patients diagnosed with CSU participated in this study. Twenty patients had positive ASST results, and 20 had negative results. The control group included 20 healthy volunteers. We found that the IL-23 (p = 0.01), IL-10 (p = 0.04) and IL-4 (p = 0.04) levels of the patient groups were significantly lower compared with those of the control group. The IL-23 (p = 0.009), IL-10 (p = 0.009), IL-4 (p = 0.001), and IL-17 (p = 0.05) levels of the ASST(–) patient group were significantly lower compared with those of the control group. In addition, the IL-4 (p = 0.03) and IFN-γ (p = 0.05) levels of the ASST(+) patient group were significantly lower compared with those of the control group, and the ASST(+) patients had a significantly higher UAS than the ASST(–) patients (p = 0.021). Conclusions These results, when considered together with current reports in the literature, indicate that immune dysregulation occurs in the pathogenesis of CSU, causing cytokine imbalance. PMID:28261034

  12. Advanced Technology Development for Stirling Convertors

    Science.gov (United States)

    Thieme, Lanny G.; Schreiber, Jeffrey G.

    2004-01-01

    A high-efficiency Stirling Radioisotope Generator (SRG) for use on potential NASA Space Science missions is being developed by the Department of Energy, Lockheed Martin, Stirling Technology Company, and NASA Glenn Research Center (GRC). These missions may include providing spacecraft onboard electric power for deep space missions or power for unmanned Mars rovers. GRC is also developing advanced technology for Stirling convertors, aimed at substantially improving the specific power and efficiency of the convertor and the overall power system. Performance and mass improvement goals have been established for second- and thirdgeneration Stirling radioisotope power systems. Multiple efforts are underway to achieve these goals, both in-house at GRC and under various grants and contracts. The status and results to date for these efforts will be discussed in this paper. Cleveland State University (CSU) is developing a multi-dimensional Stirling computational fluid dynamics code, capable of modeling complete convertors. A 2-D version of the code is now operational, and validation efforts at both CSU and the University of Minnesota are complementing the code development. A screening of advanced superalloy, refractory metal alloy, and ceramic materials has been completed, and materials have been selected for creep and joining characterization as part of developing a high-temperature heater head. A breadboard characterization is underway for an advanced controller using power electronics for active power factor control with a goal of eliminating the heavy tuning capacitors that are typically needed to achieve near unity power factors. Key Stirling developments just initiated under recent NRA (NASA Research Announcement) awards will also be discussed. These include a lightweight convertor to be developed by Sunpower Inc. and an advanced microfabricated regenerator to be done by CSU.

  13. Education and Public Outreach Programs at Columbus State University's Mead Observatory

    Science.gov (United States)

    Cruzen, S.; Rutland, C.; Carr, D.; Seckinger, M.

    2003-12-01

    Columbus State University (CSU) has made a substantial commitment to community education in astronomy and space science. Through the programs of the Mead Observatory at CSU's Coca-Cola Space Science Center, students, staff and faculty have been providing public outreach programs in astronomy for more than seven years. Recently, a generous grant from a private foundation has facilitated an astounding growth in the observatory's astronomy outreach activities. The grant made possible the purchase of a van, a portable planetarium, and additional telescope and computer equipment. It also funded a two-year scholarship that has supported a pair of CSU's science education majors who have staffed the program and made it a success. NASA, through the Georgia Space Grant Consortium, has provided additional funding for scholarships for 2003-2004. Prior to receiving these funds, the observatory program consisted of monthly open houses, occasional public observing nights at remote locations and approximately 6 to 8 school visits per year. Annually, these programs served approximately 3500 people. Since beginning the new phase of this program in October of 2001, the number of people served has soared to more than 23,000 in only 24 months. Over 60 schools have been visited, increasing our previous annual rate by nearly five times. Additional groups served include boys and girls scouting groups, state parks and other community organizations. School presentations have been designed to assist K-12 teachers in meeting science education standards. More than 200 teachers were asked to assess the program, and their responses were quite positive. More information about the program is available at our website (http://www.ccssc.org).

  14. Hacia la cobertura sanitaria universal en la detección neonatal

    Directory of Open Access Journals (Sweden)

    Marta Ascurra

    2015-08-01

    Full Text Available La cobertura sanitaria universal (CSU está ocupando el centro de los debates sobre las reformas de los sistemas de salud. Desde el 2.000, los desafíos planteados para cumplir con los Objetivos de Desarrollo del Milenio han señalado la necesidad de un “retorno del Estado” en el campo de la salud. Consecuentemente, se renovaron los compromisos y responsabilidades que competen a los Gobiernos en cuanto a sus obligaciones para con los ciudadanos y, con ello, una nueva forma de participación comprometida y solidaria para resolver problemas específicos e impostergables para el desarrollo de los pueblos. Con la CSU se podrá asegurar que todas las personas reciban los servicios sanitarios que necesitan, sin tener que pasar penurias financieras para pagarlos. Para que una comunidad o un país pueda alcanzar la CSU se deben cumplir varios requisitos como: un sistema de salud sólido, un sistema de financiación de los servicios de salud, acceso a medicamentos y tecnologías esenciales y personal sanitario bien capacitado. Los programas de detección neonatal forman parte esencial de todo servicio de salud. El país debe garantizar que todos los RN tengan acceso a la detección y el tratamiento oportunos, sin que las familias incurran en gastos considerables y tengan que realizar el pago directo en el momento de recibir el servicio. Paraguay está realizando grandes esfuerzos para el logro de la cobertura universal en la detección neonatal. En el presente artículo se pone de manifiesto la situación actual de la DN en el país en el contexto latinoamericano.

  15. Evaluation of autologous serum skin test and skin prick test reactivity to house dust mite in patients with chronic spontaneous urticaria.

    Directory of Open Access Journals (Sweden)

    Zhiqiang Song

    Full Text Available BACKGROUND: Chronic spontaneous urticaria (CSU is a common skin disorder with etiology that is not well understood. METHODS: In this study, we evaluated the prevalence of autologous serum skin test (ASST and skin prick testing (SPT to house dust mite (HDM in 862 CSU cases in China. Clinical features, courses and treatment responses were also recorded. RESULTS: The prevalence of positive ASST was 46.3%, and patients aged 30-39 years had the highest positive rate (52.1%. Positive SPT to HDM was seen in 153 patients (17.7% with the highest positive rate (34.2% in patients aged 20 or less. Patients with positive ASST had higher urticaria activity scores (UAS (4.18±0.65 vs. 3.67±0.53 but lower positive rates of HDM (24.6% vs. 37.6%, as compared with those with negative ASST (odds ratio (OR 1.84, 95% CI 1.38-2.47. Patients could be categorized into four groups based on the results of ASST and SPT to HDM and patients with positive ASST and positive SPT to HDM had the highest disease activity scores, experienced higher frequencies of angioedema, diseases duration, and required higher dosage of loratadine every month, compared with other subgroups (P<0.0001. CONCLUSIONS: Patients with CSU showed varied responses of positive ASST and varied sensitivity to HDM, Patients with positive ASST and/or positive SPT had more disease activity compared with patients with negative ASST and/or negative SPT. Further classification can be made based on the result of SPT and ASST.

  16. Transport phenomena in the close-spaced sublimation deposition process for manufacture of large-area cadmium telluride photovoltaic panels: Modeling and optimization

    Science.gov (United States)

    Malhotra, C. P.

    With increasing national and global demand for energy and concerns about the effect of fossil fuels on global climate change, there is an increasing emphasis on the development and use of renewable sources of energy. Solar cells or photovoltaics constitute an important renewable energy technology but the major impediment to their widespread adoption has been their high initial cost. Although thin-film photovoltaic semiconductors such as cadmium sulfide-cadmium telluride (CdS/CdTe) can potentially be inexpensively manufactured using large area deposition techniques such as close-spaced sublimation (CSS), their low stability has prevented them from becoming an alternative to traditional polycrystalline silicon solar cells. A key factor affecting the stability of CdS/CdTe cells is the uniformity of deposition of the thin films. Currently no models exist that can relate the processing parameters in a CSS setup with the film deposition uniformity. Central to the development of these models is a fundamental understanding of the complex transport phenomena which constitute the deposition process which include coupled conduction and radiation as well as transition regime rarefied gas flow. This thesis is aimed at filling these knowledge gaps and thereby leading to the development of the relevant models. The specific process under consideration is the CSS setup developed by the Materials Engineering Group at the Colorado State University (CSU). Initially, a 3-D radiation-conduction model of a single processing station was developed using the commercial finite-element software ABAQUS and validated against data from steady-state experiments carried out at CSU. A simplified model was then optimized for maximizing the steady-state thermal uniformity within the substrate. It was inferred that contrary to traditional top and bottom infrared lamp heating, a lamp configuration that directs heat from the periphery of the sources towards the center results in the minimum temperature

  17. Design, construction, and testing of a residential solar heating and cooling system

    Energy Technology Data Exchange (ETDEWEB)

    Ward, D.S.; Loef, G.O.G.

    1976-06-01

    The NSF/CSU Solar House I solar heating and cooling system became operational on 1 July 1974. During the first months of operation the emphasis was placed on adjustment, ''tuning,'' and fault correction in the solar collection and the solar/fuel/cooling subsystems. Following this initial check out period, analysis and testing of the system utilizing a full year of data were accomplished. This report discusses the results of this analysis of the full year of operation. (WDM)

  18. Ombres et facettes des élections allemandes

    Directory of Open Access Journals (Sweden)

    Pierre Riquet

    2006-03-01

    Full Text Available En Allemagne, élections législatives confuses en septembre 2005: le SPD a perdu mais moins que prévu, la CDU-CSU a nettement moins gagné qu’attendu. Le mode complexe de scrutin (le double vote y est pour beaucoup: à ce jeu les déports de voix au sein de la droite révèlent la permanence de comportements politiques régionaux mais aussi les progrès de l’extrême droite.

  19. Territoires institutionnels et vécus de la participation en Europe. La démocratie en questions à travers trois expériences (Berlin, Reggio Emilia, et Saint-Denis

    Directory of Open Access Journals (Sweden)

    Élise Roche

    2011-09-01

    Full Text Available Composition du juryMarie-Vic Ozouf-Marignier, Directrice de la thèse, Directrice d'étude, GGH-TERRES, EHESSYves Chalas, Professeur, PACTE-TerritoiresCatherine Neveu, Directrice de recherche, IIAC-LAIOSYves Sintomer, Professeur, CSU, IRESCODominique Rivière, Professeur, Géographie-CitésThèse soutenue le 11 décembre 2010Thèse téléchargeable à l’adresse : http://i.ville.gouv.fr/reference/6630/territoires-institutionnels-et-vecus-de-la-participation-en-europe-la-democratie-en-questionsResuméCette...

  20. 166 Assessment of Chronic Spontaneous Urticaria by Serum-Induced TNF & ALPHA; and MMP-9 Release

    OpenAIRE

    Falkencronec, Sidsel; Poulsen, Lars; Maurer, Marcus; Bindslev-Jensen, Carsten; Skov, Per Stahl

    2012-01-01

    Background Previous studies from our group have demonstrated that IgE-mediated basophil activation leads to release of TNFα that in turn can induce matrix metallo-proteinase-9 (MMP-9) release from monocytes. We wished to investigate if serum from chronic spontaneous urticaria-patients with auto-antibodies against IgE/IgE-receptor could induce TNFα and MMP-9 release from donor PBMCs, and if release levels could be used to assess severity and activity of chronic spontaneous urticaria (CSU). Met...

  1. Socavación alrededor de pilares cilíndricos en lechos no cohesivos

    OpenAIRE

    León Cuba, Arturo S.

    2000-01-01

    El presente trabajo de tesis es el resultado del estudio teórico - experimental del fenómeno de socavación alrededor de pilares cilíndricos en lechos no cohesivos, en el cual, se trató de ampliar el rango de experimentación del número de Froude del flujo, que usualmente estuvieron limitados a flujos subcríticos (lnglis, Laursen y Toch, Jaroslavtziev, Larras, Carstens, CSU, entre otros). La investigación teórica involucró un análisis cualitativo del mecanismo de erosión alrededor de un pil...

  2. NATO’s 1979 Dual-Track Decision: National Interests and the Influence of Former Political Leaders of the United States of America and the Federal Republic of Germany

    Science.gov (United States)

    2014-05-22

    249Haftendorn Sicherheit und Stabilität, 129. She stated that Brand declared himself a “non-expert” and Wehner primarily “smoked his pipe” at the meeting...Doppelbeschlusses vom 12. Dezember 1979 in seinen beiden Teilen. Antrag der Fraktionen CDU/CSU und FDP vom 18. November 1983,“ in Karl- Volker Neugebauer, ed...Entspannung.“ In Grundzüge der deutschen Militärgeschichte: Band 1, Historischer Überblick, edited by Karl- Volker Neugebauer, 420-468. Freiburg

  3. The Role of Meteorological Satellites in Tactical Battlefield Weather Support.

    Science.gov (United States)

    1982-03-17

    munition. However, the job is greatly complicated by the actions of the enemy, by the perversity and limitations of one’s own equipment, and, frequently...evolving in a particular manner. However, that behavior and evolution is precisely the concern of a major portion of a nowcast. Understanding what the...34:, Hobbs Axial symmetry particularly kce Pase Three.Dimensiona Models ilU. Wsc./3D 48 km x 48 km x Severe -storm Liquid bulk water 14 km microphysicsCSU/3D

  4. Use of ARM Data to address the Climate Change Further Development and Applications of A Multi-scale Modeling Framework

    Energy Technology Data Exchange (ETDEWEB)

    David A. Randall; Marat Khairoutdinov

    2007-12-14

    The Colorado State University (CSU) Multi-scale Modeling Framework (MMF) is a new type of general circulation model (GCM) that replaces the conventional parameterizations of convection, clouds and boundary layer with a cloud-resolving model (CRM) embedded into each grid column. The MMF that we have been working with is a “super-parameterized” version of the Community Atmosphere Model (CAM). As reported in the publications listed below, we have done extensive work with the model. We have explored the MMF’s performance in several studies, including an AMIP run and a CAPT test, and we have applied the MMF to an analysis of climate sensitivity.

  5. Renewable energy sources - an option for the future. Federal Government voices opinion

    Energy Technology Data Exchange (ETDEWEB)

    1988-08-31

    Despite unfavourable market conditions, the Federal Government wants to continue the research and development of renewable energy sources up to the 'threshold of market maturity' and - wherever practical - increase them. A 'technological gap' should be avoided. However, the current lack of economy of these forms of energy cannot be compensated for by permanent subsidies. This information is contained in the Federal Government's reply to a parliamentary question from the coalition parties of the CDU/CSU and FDP on the subject of 'Production and use of renewable energy sources in the Federal Republic of Germany'.

  6. Information Literacy in University Students: Revisiting the Concept

    Directory of Open Access Journals (Sweden)

    JORGE WINSTON BARBOSA-CHACÓN

    2008-12-01

    Full Text Available This article draws on a 2006-2007 research about information literacyin university students. Current definitions about information literacy are presented, drawing on contributions by the American College and Research Library – ACRL and the California State University – CSU. Acomplementary historical and social standpoint about information literacy is also introduced (Ferreira & Dudziak, 2004. These perspectives are the basis to build a renewed concept about information literacy framed within principles of Discursive Semiotics (Fontanille, 2001; Greimas, 1989. An analytical structure of the concept is proposed, tested and exemplified with a case study.

  7. Solid Biomass Consumption in Households and Greenhouse Gas Emission Reduction in Latvia / CIETĀS Biomasas PATĒRIŅŠ un SILTUMNĪCEFEKTA GĀZU Emisiju SAMAZINĀŠANAS PERSPEKTĪVA Latvijas MĀJSAIMNIECĪBĀS

    Science.gov (United States)

    Kudrenickis, I.; Klavs, G.

    2013-12-01

    Utilisation of biomass is an important factor in reducing emission of greenhouse gases (GHG); at the same time, high efficiency of biomass combustion technologies is to be ensured to minimise the methane (CH4) emission thus achieving the most efficient reduction in the total GHG emission. The authors analyse the GHG emission breakdown in Latvia among the sectors not included in the EU Emissions Trading Scheme (ETS), and, in the context of emission reduction, evaluate the energy supply in the Latvian household sector, the types of combustion technologies and the used fuels. The trend is considered for the CH4 emission factor during 1990-2010 in the household sector of EU countries, and the numerical index is calculated which illustrates decoupling the consumption of biomass fuel from CH4 emission. To evaluate the perspective of CH4 emission reduction in the Latvian household sector, two scenarios are investigated for efficiency improvement as related to the central heating equipment based on wood fuel. Biomasas izmantošana ir viens no principiālajiem virzieniem siltumnīcefekta gāzu (SEG) emisiju samazināšanā. Maksimāla SEG emisiju samazinājuma panākšanai ir nepieciešams nodrošināt biomasas sadedzināšanas iekārtu augstu efektivitāti, lai minimizētu ar biomasas kurināmā patēriņu saistīto metāna (CH4) emisiju pieaugumu. Autori raksturo Eiropas Savienības (ES) Emisiju kvotu tirdzniecības sistēmas (ETS) un tajā neietilpstošo sektoru (ne-ETS) nozīmi Latvijas SEG emisiju veidošanā, SEG emisiju relatīvo sadalījumu atbilstoši dažādiem ne- ETS sektoriem un SEG emisiju samazināšanas kontekstā analizē Latvijas mājsaimniecību sektora energoapgādi, patērēto kurināmo un izmantotās kurināmā sadedzināšanas tehnoloģijas. Rakstā ir demonstrēta SEG emisiju inventarizācijā pielietotā CH4 emisiju specifiskā faktora mājsaimniecību sektora koksnes kurināmajam skaitlisko vērtību dinamika 1990-2010 gados dažādās ES valst

  8. Assessment of heavy metals in Averrhoa bilimbi and A. carambola fruit samples at two developmental stages.

    Science.gov (United States)

    Soumya, S L; Nair, Bindu R

    2016-05-01

    Though the fruits of Averrhoa bilimbi and A. carambola are economically and medicinally important, they remain underutilized. The present study reports heavy metal quantitation in the fruit samples of A. bilimbi and A. carambola (Oxalidaceae), collected at two stages of maturity. Heavy metals are known to interfere with the functioning of vital cellular components. Although toxic, some elements are considered essential for human health, in trace quantities. Heavy metals such as Cr, Mn, Co, Cu, Zn, As, Se, Pb, and Cd were analyzed by atomic absorption spectroscopy (AAS). The samples under investigation included, A. bilimbi unripe (BU) and ripe (BR), A. carambola sour unripe (CSU) and ripe (CSR), and A. carambola sweet unripe (CTU) and ripe (CTR). Heavy metal analysis showed that relatively higher level of heavy metals was present in BR samples compared to the rest of the samples. The highest amount of As and Se were recorded in BU samples while Mn content was highest in CSU samples and Co in CSR. Least amounts of Cr, Zn, Se, Cd, and Pb were noted in CTU while, Mn, Cu, and As were least in CTR. Thus, the sweet types of A. carambola (CTU, CTR) had comparatively lower heavy metal content. There appears to be no reason for concern since different fruit samples of Averrhoa studied presently showed the presence of various heavy metals in trace quantities.

  9. Educating speech-language pathologists for the 21st century: course design considerations for a distance education Master of Speech Pathology program.

    Science.gov (United States)

    McCormack, Jane; Easton, Catherine; Morkel-Kingsbury, Lenni

    2014-01-01

    The landscape of tertiary education is changing. Developments in information and communications technology have created new ways of engaging with subject material and supporting students on their learning journeys. Therefore, it is timely to reconsider and re-imagine the education of speech-language pathology (SLP) students within this new learning space. In this paper, we outline the design of a new Master of Speech Pathology course being offered by distance education at Charles Sturt University (CSU) in Australia. We discuss the catalyst for the course and the commitments of the SLP team at CSU, then describe the curriculum design process, focusing on the pedagogical approach and the learning and teaching strategies utilised in the course delivery. We explain how the learning and teaching strategies have been selected to support students' online learning experience and enable greater interaction between students and the subject material, with students and subject experts, and among student groups. Finally, we highlight some of the challenges in designing and delivering a distance education SLP program and identify future directions for educating students in an online world. © 2015 S. Karger AG, Basel.

  10. Physical modeling of river spanning rock structures: Evaluating interstitial flow, local hydraulics, downstream scour development, and structure stability

    Science.gov (United States)

    Collins, K.L.; Thornton, C.I.; Mefford, B.; Holmquist-Johnson, C. L.

    2009-01-01

    Rock weir and ramp structures uniquely serve a necessary role in river management: to meet water deliveries in an ecologically sound manner. Uses include functioning as low head diversion dams, permitting fish passage, creating habitat diversity, and stabilizing stream banks and profiles. Existing information on design and performance of in-stream rock structures does not provide the guidance necessary to implement repeatable and sustainable construction and retrofit techniques. As widespread use of rock structures increases, the need for reliable design methods with a broad range of applicability at individual sites grows as well. Rigorous laboratory testing programs were implemented at the U.S. Bureau of Reclamation (Reclamation) and at Colorado State University (CSU) as part of a multifaceted research project focused on expanding the current knowledge base and developing design methods to improve the success rate of river spanning rock structures in meeting project goals. Physical modeling at Reclamation is being used to measure, predict, and reduce interstitial flow through rock ramps. CSU is using physical testing to quantify and predict scour development downstream of rock weirs and its impact on the stability of rock structures. ?? 2009 ASCE.

  11. CERT tribal internship program. Final intern report: Maria Perez, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    Historically, American Indian Tribes have lacked sufficient numbers of trained, technical personnel from their communities to serve their communities; tribal expertise in the fields of science, business and engineering being extremely rare and programs to encourage these disciplines almost non-existent. Subsequently, Tribes have made crucial decisions about their land and other facets of Tribal existence based upon outside technical expertise, such as that provided by the United States government and/or private industries. These outside expert opinions rarely took into account the traditional and cultural values of the Tribes being advised. The purpose of this internship was twofold: Create and maintain a working relationship between CERT and Colorado State University (CSU) to plan for the Summit on Tribal human resource development; and Evaluate and engage in current efforts to strengthen the Tribal Resource Institute in Business, Engineering and Science (TRIBES) program. The intern lists the following as the project results: Positive interactions and productive meetings between CERT and CSU; Gathered information from Tribes; CERT database structure modification; Experience as facilitator in participating methods; Preliminary job descriptions for staff of future TRIBES programs; and Additions for the intern`s personal database of professional contacts and resources.

  12. LDAP: a web server for lncRNA-disease association prediction.

    Science.gov (United States)

    Lan, Wei; Li, Min; Zhao, Kaijie; Liu, Jin; Wu, Fang-Xiang; Pan, Yi; Wang, Jianxin

    2017-02-01

    Increasing evidences have demonstrated that long noncoding RNAs (lncRNAs) play important roles in many human diseases. Therefore, predicting novel lncRNA-disease associations would contribute to dissect the complex mechanisms of disease pathogenesis. Some computational methods have been developed to infer lncRNA-disease associations. However, most of these methods infer lncRNA-disease associations only based on single data resource. In this paper, we propose a new computational method to predict lncRNA-disease associations by integrating multiple biological data resources. Then, we implement this method as a web server for lncRNA-disease association prediction (LDAP). The input of the LDAP server is the lncRNA sequence. The LDAP predicts potential lncRNA-disease associations by using a bagging SVM classifier based on lncRNA similarity and disease similarity. The web server is available at http://bioinformatics.csu.edu.cn/ldap jxwang@mail.csu.edu.cn. Supplementary data are available at Bioinformatics online.

  13. Antihistamine use in children.

    Science.gov (United States)

    Fitzsimons, Roisin; van der Poel, Lauri-Ann; Thornhill, William; du Toit, George; Shah, Neil; Brough, Helen A

    2015-06-01

    This review provides an overview of the use of antihistamines in children. We discuss types of histamine receptors and their mechanism of action, absorption, onset and duration of action of first-generation and second-generation H(1)-antihistamines, as well as elimination of H(1)-antihistamines which has important implications for dosing in children. The rationale for the use of H(1)-antihistamines is explored for the relief of histamine-mediated symptoms in a variety of allergic conditions including: non-anaphylactic allergic reactions, atopic eczema (AE), allergic rhinitis (AR) and conjunctivitis, chronic spontaneous urticaria (CSU) and whether they have a role in the management of intermittent and chronic cough, anaphylaxis, food protein-induced gastrointestinal allergy and asthma prevention. Second-generation H(1)-antihistamines are preferable to first-generation H(1)-antihistamines in the management of non-anaphylactic allergic reactions, AR, AE and CSU due to: their better safety profile, including minimal cognitive and antimuscarinic side effects and a longer duration of action. We offer some guidance as to the choices of H(1)-antihistamines available currently and their use in specific clinical settings. H(1)-antihistamine class, availability, licensing, age and dosing administration, recommended indications in allergic conditions and modalities of delivery for the 12 more commonly used H(1)-antihistamines in children are also tabulated.

  14. Controversies and challenges in the management of chronic urticaria.

    Science.gov (United States)

    Staubach, P; Zuberbier, T; Vestergaard, C; Siebenhaar, F; Toubi, E; Sussman, G

    2016-07-01

    This supplement reports proceedings of the second international Global Urticaria Forum, which was held in Berlin, Germany in November 2015. Despite the clear international guideline, there remain a number of controversies and challenges in the management of patients with chronic urticaria (CU). As a result of major advancements in urticaria over the past 4 years, the current EAACI/GA(2) LEN/EDF/WAO urticaria guideline treatment algorithm requires updating. Case studies from patients with chronic spontaneous urticaria (CSU) [also called chronic idiopathic urticaria (CIU)], chronic inducible urticaria (CIndU) or diseases and syndromes related to CU are useful in describing and exploring challenges in disease management. Case studies of specific CSU patient populations such as children with CU or patients with angio-edema but no hives also require consideration as potentially challenging groups with unmet needs. The current EAACI/GA(2) LEN/EDF/WAO urticaria guideline provides a general framework for the management of patients with CU but, as these cases highlight, a personalized approach based on the expert knowledge of the physician may be required. © 2016 European Academy of Dermatology and Venereology.

  15. Position statement for the use of omalizumab in the management of chronic spontaneous urticaria in Indian patients

    Directory of Open Access Journals (Sweden)

    Kiran Godse

    2016-01-01

    Full Text Available Chronic spontaneous urticaria (CSU affects 1% of the world population and also their quality of life, and 50% of these patients are refractory to H1-antihistamines. Omalizumab is a humanized monoclonal anti-IgE antibody that binds with free IgE antibodies and reduces the circulating levels of free IgE. This reduction in free IgE prevents mast-cell degranulation. The EAACI/GA2LEN/EDF/WAO guidelines recommend omalizumab as the third-line of therapy as an add-on to antihistamines. The recommended dose of omalizumab is 300 mg, 4 weekly in the management of CSU refractory to standard of care with H1-antihistamines in adults and adolescents ≥12 years of age. In some patients, a dose of 150 mg may be acceptable. Omalizumab has a good safety profile. However, due to the biologic nature of the drug, all patients administered omalizumab must be observed for 2 h after administration for anaphylactoid reactions. There have been no studies on the effect of impaired renal or hepatic function on the pharmacokinetics of omalizumab. While no particular dose adjustment is recommended, omalizumab should be administered with caution in these patients.

  16. Night-time sedating H1-antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomized controlled trial

    Science.gov (United States)

    Staevska, M; Gugutkova, M; Lazarova, C; Kralimarkova, T; Dimitrov, V; Zuberbier, T; Church, MK; Popov, TA

    2014-01-01

    Background Many physicians believe that the most effective way to treat chronic urticaria is to take a nonsedating second-generation H1-antihistamine in the morning and a sedating first-generation H1-antihistamine, usually hydroxyzine, at night to enhance sleep. But is this belief well founded? Objectives To test this belief by comparing the effectiveness and prevalence of unwanted sedative effects when treating patients with chronic spontaneous urticaria (CSU) with levocetirizine 15 mg daily plus hydroxyzine 50 mg at night (levocetirizine plus hydroxyzine) vs. levocetirizine 20 mg daily (levocetirizine monotherapy). Methods In this randomized, double-blind, cross-over study, 24 patients with difficult-to-treat CSU took levocetirizine plus hydroxyzine or levocetirizine monotherapy for periods of 5 days each. At the end of each treatment period, assessments were made of quality of life (Chronic Urticaria Quality of Life Questionnaire, CU-Q2oL), severity of urticaria symptoms (Urticaria Activity Score, UAS), sleep disturbance during the night and daytime somnolence. Results Both treatments significantly decreased UAS, night-time sleep disturbances and CU-Q2oL scores (P urticaria guidelines, which state that first-line treatment for urticaria should be new-generation, nonsedating H1-antihistamines only. PMID:24472058

  17. Autologous serum and plasma skin tests in chronic spontaneous urticaria: A reappraisal

    Directory of Open Access Journals (Sweden)

    Muthu Sendhil Kumaran

    2017-01-01

    Full Text Available Aim: The objective of this study was to assess autologous serum skin test (ASST vs autologous plasma skin test (APST response in chronic spontaneous urticaria (CSU patients and study the significance of intensity of positive responses in relation to clinicoepidemiological parameters. Materials and Methods: One hundred CSU patients and 100 age and sex-matched controls were recruited. The demographic and clinical features were recorded in all patients and routine investigations were performed. ASST and APST tests were performed as per the standard guidelines. Results: The mean duration of illness was 4.85 ± 5.07 years, 90% patients were APST (+, 68% ASST (+, and 22 patients were only APST (+. Positive predictive value (PPV of ASST and APST was 90.7% and 95.7%, respectively. A significant inverse association was seen between thyroid status and serum IgE levels with APST and ASST positivity. Conclusion: APST appears to have better PPV and high intensity of positive response on autologous tests, and correlates with ANA positivity and angioedema.

  18. Operation of JET as a user facility

    Energy Technology Data Exchange (ETDEWEB)

    Kaye, Alan S. E-mail: ask@jet.uk; Cox, M.; Farthing, J.W.; Hitchin, M.; Lomas, P

    2003-09-01

    Since the beginning of 2000, the Joint European Torus (JET) has been operated under the European fusion development agreement (EFDA) as a user facility. The UKAEA as 'operator' maintains and operates the facility and installs enhancements on behalf of EFDA under contract to the European Commission. The experimental programme is proposed and implemented by the 'users', scientists and engineers on secondment from the European fusion laboratories, which also supply equipment for enhancement of the facility. The overall programme is co-ordinated by the close support unit (CSU). During the five experimental campaigns to date, the historical rate of successful pulsing has been largely maintained. One major shutdown has been completed with substantial in-vessel and ex-vessel tasks, and various small enhancements have been installed. The first major enhancement is imminent. The UKAEA is independently responsible for safety and the environmental impact of the project. This paper reviews the requirements and procedures for control of the interface between the operator, the CSU and users, presents performance measures for key aspects, and summarises the experience of the UKAEA in the operation of JET.

  19. Acinetobacter baumannii biofilms: variations among strains and correlations with other cell properties.

    Science.gov (United States)

    McQueary, Christin N; Actis, Luis A

    2011-04-01

    Acinetobacter baumannii is an opportunistic pathogen that causes serious infections in humans by colonizing and persisting on surfaces normally found in hospital settings. The capacity of this pathogen to persist in these settings could be due to its ability to form biofilms on inanimate surfaces. This report shows that although the ATCC 19606(T) type strain and 8 different clinical isolates form biofilms, there are significant variations in the cell density and microscopic structures of these cell aggregates, with 3 of the isolates forming pellicles floating on the surface of stagnant broth cultures. PCR indicated that, like ATCC 19606(T), all 8 clinical isolates harbor all the genetic components of the CsuA/BABCDE chaperone-usher pili assembly system, which is needed for biofilm formation on plastic. Pili detection in cells of all strains examined supports the presence and function of a pilus assembly system. However, only one of them produced the putative ATCC 19606(T) CsuA/B pilin subunit protein. Hydrophobicity tests and motility assays also showed significant variations among all tested strains and did not result in direct correlations between the biofilm phenotype and cell properties that could affect biofilm formation on abiotic surfaces. This lack of correlation among these 3 phenotypes may reflect some of the variations already reported with this pathogen, which may pose a challenge in the treatment of the infections this pathogen causes in humans using biofilm formation on abiotic surfaces as a target.

  20. Using the Mountain Pine Beetle Infestation of the Rocky Mountain West to Develop a Collaborative, Experiential Course on Science Communication

    Science.gov (United States)

    Gallagher, L.; Morse, M.; Maxwell, R. M.; Cottrell, S.; Mattor, K.

    2016-12-01

    An ongoing NSF-WSC project was used as a launchpad for implementing a collaborative honors course at the Colorado School of Mines (CSM) and Colorado State University (CSU). The course examined current physical and social science research on the effects of the Mountain Pine Beetle (MPB) on regional social and hydro-ecological systems in the Rocky Mountain West. In addition to general classroom content delivery, community outreach experience and development for the participating undergraduate students was integrated into the course. Upon learning about ongoing MPB research from project PIs and researchers, students were guided to develop their own methodology to educate students and the community about the main project findings. Participants at CSM and CSU worked together to this end in a synchronous remote classroom environment. Students at both universities practiced their methods and activities with various audiences, including local elementary students, other undergraduate and graduate peers, and delivered their activities to sixth-grade students at a local outdoor lab program (Windy Peak Outdoor Lab, Jefferson County, CO). Windy Peak Outdoor Lab has integrated the student-developed content into their curriculum, which reaches approximately 6,000 students in the Jefferson County, CO school district each year. This experiential learning course will be used as a template for future Honors STEM education course development at CSM and was a unique vessel for conveying the studied effects of the MPB to a K-12 audience.

  1. Anti-adhesion and antibiotic modulatory evaluation of grapefruit (Citrus paradisi juice and seed extract on bacteria isolated from urine and catheter

    Directory of Open Access Journals (Sweden)

    Michael Oluwole Osungunna

    2016-02-01

    Full Text Available Context: The in vivo use of grapefruit seed in the treatment of urinary tract infections (UTIs has been reported but the mechanism of action is yet to be explained. Aims: Evaluate the anti-adhesion and antibiotic modulatory activities of grapefruit seed extract and juice as their possible mechanisms of action. Methods: Sub-inhibitory concentrations of 2.5 and 5 mg/mL as well as 10.3 and 5.15 mg/mL of grapefruit seed extract and juice respectively were evaluated for modulatory activity of ciprofloxacin, streptomycin and nalidixic acid against one hundred and twenty seven bacterial isolates from mid-stream urine (MSU (100, catheter-stream urine (CSU (14 and catheter tips (CT (13 using the agar dilution method. Anti-adhesion activity of grapefruit seed extract and juice at sub-inhibitory concentrations of 2.5 and 1.03 mg/mL respectively was evaluated against twenty three (23 moderately adherent bacterial isolates from MSU (10, CSU (7 and CT (6 using the tissue culture plate method. Results: The results revealed that grapefruit juice (5.15 mg/mL showed more effect on nalidixic acid activity than seed extract (2.5 mg/mL. Grapefruit juice showed more anti-adhesion activity than grapefruit seed extract at the concentration tested. Conclusions: The study concluded that grapefruit seed extract and juice had anti-adhesion and antibiotic modulatory effects on bacteria associated with UTIs.

  2. Recovery Act - Sustainable Transportation: Advanced Electric Drive Vehicle Education Program

    Energy Technology Data Exchange (ETDEWEB)

    Caille, Gary

    2013-12-13

    The collective goals of this effort include: 1) reach all facets of this society with education regarding electric vehicles (EV) and plug–in hybrid electric vehicles (PHEV), 2) prepare a workforce to service these advanced vehicles, 3) create web–based learning at an unparalleled level, 4) educate secondary school students to prepare for their future and 5) train the next generation of professional engineers regarding electric vehicles. The Team provided an integrated approach combining secondary schools, community colleges, four–year colleges and community outreach to provide a consistent message (Figure 1). Colorado State University Ventures (CSUV), as the prime contractor, plays a key program management and co–ordination role. CSUV is an affiliate of Colorado State University (CSU) and is a separate 501(c)(3) company. The Team consists of CSUV acting as the prime contractor subcontracted to Arapahoe Community College (ACC), CSU, Motion Reality Inc. (MRI), Georgia Institute of Technology (Georgia Tech) and Ricardo. Collaborators are Douglas County Educational Foundation/School District and Gooru (www.goorulearning.org), a nonprofit web–based learning resource and Google spin–off.

  3. Configurable slit-mask unit of the Multi-Object Spectrometer for Infra-Red Exploration for the Keck telescope: integration and tests

    Science.gov (United States)

    Spanoudakis, Peter; Giriens, Laurent; Henein, Simon; Lisowski, Leszek; O'Hare, Aidan; Onillon, Emmanuel; Schwab, Philippe; Theurillat, Patrick

    2008-07-01

    A Configurable Slit Unit (CSU) has been developed for the Multi-Object Spectrometer for Infra-Red Exploration (MOSFIRE) instrument to be installed on the Keck 1 Telescope on Mauna Kea, Hawaii. MOSFIRE will provide NIR multi-object spectroscopy over a field of view of 6.1' x 6.1'. The reconfigurable mask allows the formation of 46 optical slits in a 267 x 267 mm2 field of view. The mechanism is an evolution of a former prototype designed by CSEM and qualified for the European Space Agency (ESA) as a candidate for the slit mask on NIRSpec for the James Webb Space Telescope (JWST). The CSU is designed to simultaneously displace masking bars across the field-of-view (FOV) to mask unwanted light. A set of 46 bar pairs are used to form the MOSFIRE focal plane mask. The sides of the bars are convoluted so that light is prevented from passing between adjacent bars. The slit length is fixed (5.1 mm) but the width is variable down to 200 μm with a slit positioning accuracy of +/- 18 μm. A two-bar prototype mechanism was designed, manufactured and cryogenically tested to validate the modifications from the JWST prototype. The working principle of the mechanism is based on an improved "inch-worm" stepping motion of 92 masking bars forming the optical mask. Original voice coil actuators are used to drive the various clutches. The design makes significant use of flexure structures.

  4. Visualization of Alternative Functional Configurations of Influenza Virus Hemagglutinin Facilitates Rapid Selection of Complementing Vaccines in Emergency Situations

    Science.gov (United States)

    Metwally, Ashraf; Yousif, Ausama

    2017-01-01

    Successful immunization against avian influenza virus (AIV) requires eliciting an adequate polyclonal response to AIV hemagglutinin (HA) subunit 1 (HA1) epitopes. Outbreaks of highly-pathogenic (HP) AIV subtype H5N1 can occur in vaccinated flocks in many endemic areas. Protection against emerging AIV is partly hindered by the limitations of vaccine production and transport, the use of leaky vaccines, and the use of multiple, and often antigenically-diverse, vaccines. It was hypothesized that the majority of alternative functional configurations (AFC) within the AIV HA1 can be represented by the pool of vaccine seed viruses currently in production because only a finite number of AFC are possible within each substructure of the molecule. Therefore, combinations of commercial vaccines containing complementing structural units (CSU) to each HA1 substructure can elicit responses to the totality of a given emerging AIV HA1 substructure isoforms. Analysis of homology-based 3D models of vaccine seed and emerging viruses facilitated the definition of HA1 AFC isoforms. CSU-based plots were used to predict which commercial vaccine combinations could have been used to cover nine selected AFC isoforms on recent Egyptian HP AIV H5N1 outbreak viruses. It is projected that expansion of the vaccine HA1 3D model database will improve international emergency responses to AIV. PMID:28375167

  5. Visualization of Alternative Functional Configurations of Influenza Virus Hemagglutinin Facilitates Rapid Selection of Complementing Vaccines in Emergency Situations

    Directory of Open Access Journals (Sweden)

    Ashraf Metwally

    2017-04-01

    Full Text Available Successful immunization against avian influenza virus (AIV requires eliciting an adequate polyclonal response to AIV hemagglutinin (HA subunit 1 (HA1 epitopes. Outbreaks of highly-pathogenic (HP AIV subtype H5N1 can occur in vaccinated flocks in many endemic areas. Protection against emerging AIV is partly hindered by the limitations of vaccine production and transport, the use of leaky vaccines, and the use of multiple, and often antigenically-diverse, vaccines. It was hypothesized that the majority of alternative functional configurations (AFC within the AIV HA1 can be represented by the pool of vaccine seed viruses currently in production because only a finite number of AFC are possible within each substructure of the molecule. Therefore, combinations of commercial vaccines containing complementing structural units (CSU to each HA1 substructure can elicit responses to the totality of a given emerging AIV HA1 substructure isoforms. Analysis of homology-based 3D models of vaccine seed and emerging viruses facilitated the definition of HA1 AFC isoforms. CSU-based plots were used to predict which commercial vaccine combinations could have been used to cover nine selected AFC isoforms on recent Egyptian HP AIV H5N1 outbreak viruses. It is projected that expansion of the vaccine HA1 3D model database will improve international emergency responses to AIV.

  6. The Cal-Bridge Program: Increasing the Gender and Ethnic Diversity of Astrophysics Students in Southern California

    Science.gov (United States)

    Smecker-Hane, Tammy A.; Rudolph, Alexander L.

    2016-06-01

    The mission of the Cal-Bridge program is to increase the number of underrepresented minority and women students completing a bachelor’s degree and entering a PhD program in astronomy, physics, or closely-related fields. The program has created a network of faculty at diverse higher education institutions, including 5 University of California (UC) campuses, 9 California State Universities (CSUs), and 10 community colleges in southern California, dedicated to this goal. Students selected for the program are know as “Cal-Bridge Scholars” and they are given a wide variety of support: (1) scholarships in their junior/senior years at CSU and their first year of graduate school at a UC, (2) intensive mentoring by a pair of CSU and UC faculty members, (3) tutoring, when needed, (4) professional development workshops, (5) exposure to research opportunities at various universities, and (6) membership in a growing cohort of like-minded students. We report on the structure of our program, lessons learned with our current 12 Cal-Bridge scholars, and the results of our first two years of operation. Funding for this program is provided by NSF-SSTEM Grant #1356133.

  7. [Inducible urticaria and chronic spontaneous urticaria].

    Science.gov (United States)

    Du Thanh, A

    2014-11-01

    In the recently published 2013 revision of the guidelines of urticaria, chronic urticaria (CU) gathers chronic spontaneous urticaria (CSU) and inducible urticaria (IU), and excludes pseudourticarial rashes with more than 24h-lasting rash or more than 72h-lasting angiœdema. Activity and psychosocial impact of the disease must be measured with validated scores such as Urticaria and Angioedema Activity Scores, Urticaria Control Test, CU-Q2OL, AE-QOL. Although an allergic cause is generaly absent in CU, pathomecanisms remain elusive even since the well-known role of mast cell degranulation and the presence of autoantibodies anti-FcRεI or anti-IgE. Coagulation pathways may be involved, at least as an amplifying phenomenon. Mean duration of CU is 1 to 4 years, but many patients still have symptoms after 10 years, some predictive factors being known as severity, angioedema, a positive autologous serum test, inducible urticaria. Recommended routine diagnosic tests are validated provocation tests for IU (and cryoproteins for cold urticaria), blood cell count and CRP for CSU, since a thorough history and a normal detailed physical examination should avoid unnecessary tests. Management of CU has been improved by the off-label use of increased dosages of second generation anti- H1 antihistamines, but a subsequent therapeutic intensification may be necessary in some cases. Educational program may prevent this intensification. Independent studies evaluating available molecules are needed, along with more fundamental research studies.

  8. CAMPARE and Cal-Bridge: Two Institutional Networks Increasing Diversity in Astronomy

    Science.gov (United States)

    Rudolph, Alexander L.; Smecker-Hane, Tammy A.

    2017-01-01

    We describe two programs, CAMPARE and Cal-Bridge, with the common mission of increasing participation of groups traditionally underrepresented in astronomy, through summer research opportunities, in the case of CAMPARE, scholarships in the case of Cal-Bridge, and significant mentoring in both programs, creating a national impact on their numbers successfully pursuing a PhD in the field.In 7 years, the CAMPARE program has sent 80 students, >80% from underrepresented groups, to conduct summer research at one of 14 major research institutions throughout the country. The graduation rate among CAMPARE scholars is 98%, and of the CAMPARE scholars who have graduated with a Bachelor’s degree, more than 60% have completed or are pursuing graduate education in astronomy or a related field, at institutions including UCLA, UC Riverside, UC Irvine, UC Santa Barbara, USC, Stanford, Univ. of Arizona, Univ. of Washington, and the Fisk-Vanderbilt Master’s-to-PhD program.Now entering its third year, the Cal-Bridge program is a CSU-UC Bridge program comprised of over 75 physics and astronomy faculty from 5 University of California (UC), 9 California State University (CSU), and 14 California Community College (CCC) campuses in Southern California. In the first three years, 22 Cal-Bridge Scholars have been selected, including 11 Hispanic, 3 African-American and 8 female students, 5 of whom are from URM groups. Nineteen (19) of the 22 Cal-Bridge Scholars are first-generation college students. The entire first cohort of 4 Cal-Bridge scholars was accepted to one or more PhD programs in astronomy or physics, including UC Irvine, UC Santa Cruz, UC Davis, Michigan State, and Georgia State Universities. The second cohort of 8 Cal-Bridge scholars is applying to graduate schools this fall.Cal-Bridge provides much deeper mentoring and professional development experiences over the last two years of undergraduate and first year of graduate school to students from this diverse network of higher

  9. Effectiveness of Autologous Whole-Blood Injections in Patients with Refractory Chronic Spontaneous Urticaria.

    Science.gov (United States)

    Kitsioulis, Nikolaos Aggelis; Xepapadaki, Paraskevi; Roussaki-Schulze, Aggeliki-Victoria; Papadopoulos, Nikolaos; Zafiriou, Efterpi

    2017-01-01

    Nonsedating antihistamines are the treatment of choice for chronic spontaneous urticaria (CSU), while omalizumab and immunosuppressants have also been approved as an add-on treatment. Autologous whole-blood injection (AWBI) has been used in previous studies with ambiguous results. The aim of our study was to evaluate changes in the Urticaria Activity Score (UAS7), Dermatology Life Quality Index (DLQI), and Chronic Urticaria Quality of Life (CU-Q2oL) score, and also the association of serologic markers with disease severity measures after AWBI. In this observational study, AWBIs were performed (8 courses on a weekly basis) in adults with refractory CSU, who refused an add-on treatment with either omalizumab or immunosuppressants. UAS7, DLQI, and CU-Q2oL questionnaires and serum concentrations of total IgE, C-reactive protein (CRP), and D-dimer were evaluated before and after the intervention. Nineteen patients (12 females; mean age 54 ± 20.8 years) completed the protocol. Following AWBI, significant improvements in the UAS7 (34.26 ± 8.04 vs. 12.52 ± 10.83, p < 0.001), DLQI (11.63 ± 5.51 vs. 3.47 ± 2.85, p < 0.001), and CU-Q2oL score (32.97 ± 18.71 vs. 10.94 ± 7.71, p < 0.001) were recorded. A negative correlation between the baseline D-dimer levels and UAS7 and DLQI variations (p = 0.002 and p = 0.001, respectively) was noted. D-dimer levels ≥292 ng/mL have been associated with poor responsiveness (sensitivity 75%; specificity 83.3%). No correlation with either total immunoglobulin E or CRP levels was observed. AWBI appears to be a safe, alternative, add-on therapeutic option in refractory CSU, particularly in patients with low plasma levels of D-dimer. © 2017 S. Karger AG, Basel.

  10. CAMPARE and Cal-Bridge: Two Institutional Networks Increasing Diversity in Astronomy

    Science.gov (United States)

    Rudolph, Alexander L.; Impey, Chris David; Phillips, Cynthia B.; Povich, Matthew S.; Prather, Edward E.; Smecker-Hane, Tammy A.

    2015-01-01

    We describe two programs, CAMPARE and Cal-Bridge, with the common mission of increasing participation of groups traditionally underrepresented in astronomy, particularly underrepresented minorities and women, through summer research opportunities, in the case of CAMPARE, scholarships in the case of Cal-Bridge, and significant mentoring in both programs, leading to an increase in their numbers successfully pursuing a PhD in the field.CAMPARE is an innovative REU-like summer research program, currently in its sixth year, comprising a network of comprehensive universities and community colleges in Southern California and Arizona (most of which are minority serving institutions), and ten major research institutions (University of Arizona Steward Observatory, the SETI Institute, JPL, Caltech, and the five Southern California UC campuses, UCLA, UCI, UCSD, UCR, and UCSB).In its first five summers, CAMPARE sent a total of 49 students from 10 different CSU and community college campuses to 5 research sites of the program. Of these 49 participants, 25 are women and 24 are men; 22 are Hispanic, 4 are African American, and 1 is Native American, including 6 female Hispanic and 2 female African-American participants. Twenty-one (21) CAMPARE participants have graduated from college, and more than half (11) have attended or are attending a graduate program, including 8 enrolled in PhD or Master's-to-PhD programs. Over twenty CAMPARE students have presented at the AAS and other national meetings.The Cal-Bridge program is a diverse network of higher education institutions in Southern California, including 5 UC campuses, 8 CSU campuses, and 7 community colleges dedicated to the goal of increasing the number of underrepresented minority and female students attending graduate school in astronomy or related fields. We have recently selected our inaugural group of five 2014 Cal-Bridge Scholars, including four women (two Hispanic and one part Native American), and one Hispanic man

  11. Study on properties of residue-residue contacts in protein

    Institute of Scientific and Technical Information of China (English)

    王向红; 柯见洪; 郑亦庄; 陈爱; 徐银香

    2004-01-01

    Residue-residue contacts are very important in forming protein structure. In this work, we calculated the average probability of residue-residue contacts in 470 globular proteins and analyzed the distribution of contacts in the different interval of residues using Contacts of Structural Units (CSU) and Structural Classification (SCOP) software. It was found that the relationship between the average probability PL and the residue distance L for four structural classes of proteins could be expressed as lgPL=a+b×L, where a and b are coefficients. We also discussed the connection between two aspects of proteins which have equal array residue number and found that the distribution probability was stable (or un-stable) if the proteins had the same (or different) comnact (for examnle svnthase) in the same structural class.

  12. Overview 2003 of NASA Multi-D Stirling Convertor Code Development and DOE and NASA Stirling Regenerator R and D Efforts

    Science.gov (United States)

    Tew, Roy; Ibrahim, Mounir; Simon, Terry; Mantell, Susan; Gedeon, David; Qiu, Songgang; Wood, Gary

    2004-01-01

    This paper win report on continuation through the third year of a NASA grant for multi-dimensional Stirling CFD code development and validation; continuation through the third and final year of a Department of Energy, Golden Field Office (DOE), regenerator research effort and a NASA grant for continuation of the effort through two additional years; and a new NASA Research Award for design, microfabrication and testing of a "Next Generation Stirling Engine Regenerator." Cleveland State University (CSU) is the lead organization for all three efforts, with the University of Minnesota (UMN) and Gedeon Associates as subcontractors. The Stirling Technology Company and Sun power, Inc. acted as unfunded consultants or participants through the third years of both the NASA multi-D code development and DOE regenerator research efforts; they win both be subcontractors on the new regenerator microfabrication contract.

  13. Study on properties of residue-residue contacts in protein

    Institute of Scientific and Technical Information of China (English)

    王向红; 柯见洪; 郑亦庄; 陈爱; 徐银香

    2004-01-01

    Residue-residue contacts are very important in forming protein structure. In this work, we calculated theaverage probability of residue-residue contacts in 470 globular proteins and analyzed the distribution of contacts in thedifferent interval of residues using Contacts of Structural Units (CSU) and Structural Classification (SCOP) software. Itwas found that the relationship between the average probability -PL and the residue distance L for four structural classes ofproteins could be expressed as lgPL=a+b×L, where a and b are coefficients. We also discussed the connection between twoaspects of proteins which have equal array residue number and found that the distribution probability was stable (or un-stable) if the proteins had the same (or different) compact (for example synthase) in the same structural class.

  14. Research for Design: Exploring Student and Instructor Attitudes toward Accessing Library Resources and Services from Course Management Systems (CMS

    Directory of Open Access Journals (Sweden)

    Merinda McLure

    2010-10-01

    Full Text Available The authors report a study concerning student and instructor attitudes toward accessing library resources and services from within course management systems (CMS. In spring 2008, the authors conducted semi-structured interviews with a small population of students and instructors at the University of California, Berkeley (UCB and at Colorado State University (CSU. They asked participants to respond to examples of library integrations in course management systems at other institutions and to report their local experiences with both the campus CMS and library services. Participant responses frequently challenged and complicated the authors’ assumptions about best practices in integrating a library presence and library services in CMS. The interview findings are discussed thematically, in relation to higher education and library literature, and can inform librarians’ efforts to integrate an effective library presence in a campus course management system. This study might be readily adapted for implementation at other institutions.

  15. Methane production by anaerobic digestion of biomass. Final report of innovative research program subtask, December 1977--September 1978

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, V G

    1978-10-01

    It has long been known that methane is produced during the anaerobic digestion of agricultural wastes, but this potential source of fuel has not been greatly exploited in the United States. The chief reason is that anaerobic decomposition of lignocellulosic materials occurs very slowly, resulting in a need for long detention times and large digestion vessels, both of which markedly increase process costs. However, recent work at CSU has shown that pretreatment of manure fibers (an abundant agricultural waste) with saturated steam at 130 to 210/sup 0/C renders this material more susceptible to attack by microbial enzymes. The main objectives of this project were to identify the chemical events occurring during the steam treatment and to correlate these with the rate of methane generating during subsequent anaerobic digestion. The study was expected to lead to an optimal pretreatment strategy.

  16. Teaching nurses to focus on the health needs of populations: a Master's Degree Program in Population Health Nursing.

    Science.gov (United States)

    Frisch, Noreen Cavan; George, Valerie; Govoni, Amy L; Jennings-Sanders, Andrea; McCahon, Cheryl P

    2003-01-01

    Responding to the mandate to prepare nurses for practice in population-based healthcare, the faculty at Cleveland State University (CSU) developed a unique Master of Science in Nursing program to prepare Population Health Nurse Experts. The program prepares nurses to examine the health status of populations and to design, implement, and evaluate nursing interventions accounting for the varied factors impacting on the health of a defined group. The speciality of population health nursing is practiced by nurses who can use population sciences (epidemiology, demography, population projections, and population behavioral theories) along with post-baccalaureate nursing competencies to work with defined populations across care environments. The authors discuss a curriculum that prepares nurses for this emerging speciality.

  17. Graphical representations of vector functions in upper-division E&M

    Science.gov (United States)

    Gire, Elizabeth; Price, Edward

    2012-02-01

    In upper division electricity and magnetism, the manipulation and interpretation of vector functions is pervasive and a significant challenge to students. At CSU San Marcos, using in-class activities adapted from the Oregon State University Paradigms in Physics Curriculum, students' difficulties with vector functions become evident in two types of in-class activities: sketching vector functions and relating vector and scalar functions (e.g., electric field and electric potential). For many students, the cause of these difficulties is a failure to fully distinguish between the components of a vector function and its coordinate variables. To address this difficulty, we implement an additional inclass activity requiring students to translate between graphical and algebraic representations of vector functions. We present our experience with these issues, how to address them, and how in-class activities can provide evidence of student thinking that facilitates curricular refinement.

  18. Geochemical zoning and early differentiation in the moon

    Science.gov (United States)

    Taylor, S. R.; Jakes, P.

    1977-01-01

    The volatile elements (e.g., Rb, Pb, Tl, Bi, Cs) seem to have been depleted at the time of lunar accretion. Accordingly, it may be assumed that the moon initially accreted from refractory material. The good correlation between volatile/involatile element ratios (e.g., Cs/U, K/La, K/Zr) in both highland and maria samples means that element distribution in lunar crustal rocks is not governed by volatility differences. This and other evidence encourages the view that the moon was accreted homogeneously. A consequence of homogeneous accretion theories is that very efficient large-scale element fractionation is required to account both for the high near-surface concentrations of refractory elements (e.g., Th, U, REE, Zr, Ba, etc.) and for the Ca-Al-rich crust.

  19. Assessment of chronic spontaneous urticaria by serum-induced tumor necrosis factor alpha and matrix metalloproteinase-9 release

    DEFF Research Database (Denmark)

    Falkencrone, Sidsel; Bindslev-Jensen, Carsten; Skov, Per Stahl

    BACKGROUND Previous studies from our group have demonstrated that IgE-mediated basophil activation leads to release of TNFα that in turn can induce matrix metallo-proteinase-9 (MMP-9) release from monocytes. We wished to investigate if serum from chronic spontaneous urticaria-patients with auto......-antibodies against IgE/IgE-receptor could induce TNFα and MMP-9 release from donor PBMCs, and if release levels could be used to assess severity and activity of chronic spontaneous urticaria (CSU). METHODS Peripheral blood mononuclear cells (PBMCs) were isolated from whole blood from healthy donors and basophils...... observed to induce highly significant MMP-9 and TNFα release from donor PBMCs when compared to sera from healthy controls (pUrticaria assessment score (UAS) did not appear to correlate with release levels for histamine, TNFa or MMP-9 in either group but in the ASST+ group, the ASST score appeared...

  20. Superspace Cavity QED Blackbody Equilibrium Modes Delineating CMBR Emission and Non-Doppler Redshift Absorption

    Science.gov (United States)

    Amoroso, Richard

    2004-05-01

    A blackbody equilibrium cavity QED theory for CMBR as emission and non-Doppler redshift as absorption is formulated utilizing an advanced form of Einstein's steady state cosmology. This Continuous State Universe (CSU) is based on a highly ordered periodic superspace that includes an energy dependent spacetime metric. The formalism for the superspace is derived by extending the Wheeler-Feynman absorber theory of radiation to the topology of the 12D periodic superspace. A fundamental least unit contains a core of Dirac spherical rotation with an inherent continuous compactification and dimensional reduction. It is shown formally that parameters of this cosmology demonstrate blackbody equilibrium conditions compatible with modes of emission and absorption suitable for describing CMBR and non-Doppler redshift.

  1. Effects of Low-Dose Alpha-Particle Irradiation in Human Cells: The Role of Induced Genes and the Bystander Effect. Final Technical Report (9/15/1998-5/31/2005)

    Energy Technology Data Exchange (ETDEWEB)

    Little, John B.

    2013-09-17

    This grant was designed to examine the cellular and molecular mechanisms for the bystander effect of radiation (initially described in this laboratory) whereby damage signals are passed from irradiated to non-irradiated cells in a population. These signals induce genetic effects including DNA damage, mutations and chromosomal aberrations in the nonirradiated cells. Experiments were carried out in cultured mammalian cells, primarily human diploid cells, irradiated with alpha particles. This research resulted in 17 publications in the refereed literature and is described in the Progress Report where it is keyed to the publication list. This project was initiated at the Harvard School of Public Health (HSPH) and continued in collaboration with students/fellows at Colorado State University (CSU) and the New Jersey Medical School (NJMS).

  2. Note on classical string dynamics on AdS3

    Science.gov (United States)

    Bañados, Máximo; Ritz, Adam

    1999-12-01

    We consider bosonic strings propagating on Euclidean anti-de Sitter space (AdS3), and study in particular the realization of various worldsheet symmetries. We give a proper definition for the Brown-Henneaux asymptotic target space symmetry, when acting on the string action, and derive the Giveon-Kutasov-Seiberg worldsheet contour integral representation simply by using Noether's theorem. We show that making identifications in the target space is equivalent to the insertion of an (exponentiated) graviton vertex operator carrying the corresponding charge. Finally, we point out an interesting relation between 3D gravity and the dynamics of the worldsheet on AdS3. Both theories are described by an SL(2,C)/SU(2) Wess-Zumino-Witten (WZW) model, and we prove that the reduction conditions determined on one hand by worldsheet diffeomorphism invariance, and on the other by the Brown-Henneaux boundary conditions, are the same.

  3. Direct contact liquid-liquid heat exchanger for solar heated and cooled buildings

    Science.gov (United States)

    Karaki, S.; Brothers, P.

    1980-06-01

    The technical and economic feasibility of using a direct contract liquid-liquid heat exchanger (DCLLHE) storage unit in a solar heating and cooling system is established. Experimental performance data were obtained from the CSU Solar House I using a DCLLHE for both heating and cooling functions. A simulation model for the system was developed. The model was validated using the experimental data and applied in five different climatic regions of the country for a complete year. The life-cycle cost of the system was estimated for each application. The results are compared to a conventional solar system, using a standard shell-and-tube heat exchanger. It is concluded that while there is a performance advantage with a DCLLHE system over a conventional solar system, the advantage is not sufficiently large to overcome slightly higher capital and operating costs for the DCLLHE system.

  4. Aging of Black Carbon during Atmospheric Transport: Understanding Results from the DOE's 2010 CARES and 2012 ClearfLo Campaigns

    Energy Technology Data Exchange (ETDEWEB)

    Subramanian, R. [Carnegie Mellon Univ., Pittsburgh, PA (United States); Mazzoleni, Claudio [Michigan Technological Univ., Houghton, MI (United States)

    2016-08-31

    Over the course of this project, we have analyzed data and samples from the CARES and ClearfLo campaigns, as well as conducted or participated in laboratory experiments designed to better understand black carbon mixing state and climate-relevant properties. The laboratory campaigns took place at PNNL and CMU to study various climate-relevant aerosol properties of different sources of soot mixing with secondary organic aerosol precursors. The DMT photoacoustic extinctiometers (PAXs) procured by CMU through this grant were deployed for these experiments, as well as experiments characterizing the optical properties of cookstove soot emissions at Colorado State University (CSU). Results from some of these activities were summarized in the previous progress report. This final report presents the manuscripts that have been published (many in the period since the last progress report), lists presentations at different conferences based on grant-related activities, and presents some results that are likely to be submitted for publication in 2016.

  5. Manchester Ice Nucleus Counter (MINC) measurements from the 2007 International workshop on Comparing Ice nucleation Measuring Systems (ICIS-2007)

    Science.gov (United States)

    Jones, H. M.; Flynn, M. J.; Demott, P. J.; Möhler, O.

    2011-01-01

    An ice nucleus counter was developed and constructed to enable investigation of potential ice nucleating materials. The Manchester Ice Nucleus Chamber (MINC) is a concentric-cylinder continuous flow diffusion chamber (CFDC). A full explanation of the MINC instrument is given here, along with first results and a comparison to an established instrument of similar design (Colorado State University CFDC) during sampling of common ice nucleating aerosols at the 2007 International workshop on Comparing Ice nucleation Measuring Systems (ICIS-2007). MINC and CSU-CFDC detected the onset of ice nucleation under similar conditions of temperature and supersaturation for several different types of ice nuclei. Comparisons of the ratio of ice nuclei to total aerosol concentrations as a function of supersaturation with respect to water (SSw) showed agreement within one order of magnitude. Possible reasons for differences between the two instruments relating to differences in their design are discussed, along with suggestions to future improvements to the current design.

  6. Cultural toolkits in the urban physics learning community

    Science.gov (United States)

    Sabella, Mel S.; Van Duzor, Andrea Gay

    2013-01-01

    Chicago State University has been involved in curriculum development, teacher preparation, and education research that targets urban physics learners on the south-side of Chicago. Through this work we have begun to recognize specific cultural norms that our students bring to the classroom. These cultural norms appear to help our students establish strong communities in classes. Because of the homogeneity of our population, with most students coming from within a five-mile radius of our campus, there are a set of shared experiences that help establish a level of trust and sense of community that manifests itself in the science learning environment. Aspects of community play a major role in the preparation of teachers. In this paper we discuss our understanding of CSU student culture, its importance in the development of community, and its role in the preparation of future physics teachers. [1

  7. [Biodegradation mechanism of DDT and chlorpyrifos using molecular simulation].

    Science.gov (United States)

    Lin, Yu-Zhen; Zeng, Guang-Ming; Zhang, Yu; Chen, Ming; Jiang, Min; Zhang, Jia-Chao; Lu, Lun-Hui; Liu, Li-Feng

    2012-03-01

    In order to explore the microscopic degradation mechanism of organic pesticides degrading enzymes, we used molecular docking method to investigate the binding modes of DDT to laccase and chlorpyrifos to organophosphorus hydrolase, and obtained the corresponding complex structures. According to the principle of minimum scoring, the results showed that the MolDock scores were -103.134 and -111.626, re-rank scores were -72.858 and -80.261, respectively. And we used LPC/CSU server search the interactions between organic pesticides and their degrading enzymes. Our results showed that hydrophobic interaction was the strongest contacts in DDT-laccase complex, and both hydrogen bonds and hydrophobic interactions were the strongest contacts when chlorpyrifos-organophosphorus hydrolase complex. The amino acid residues Tyr224 in laccase and Arg254 in organophosphorus hydrolase were detected to play significant roles in catalytic processes.

  8. Direct contact liquid-liquid heat exchanger for solar heated and cooled buildings. Final report, January 1, 1979-May 30, 1980

    Energy Technology Data Exchange (ETDEWEB)

    Karaki, S.; Brothers, P.

    1980-06-01

    The technical and economic feasibility of using a direct contact liquid-liquid heat exchanger (DCLLHE) storage unit in a solar heating and cooling system is established. Experimental performance data were obtained from the CSU Solar House I using a DCLLHE for both heating and cooling functions. A simulation model for the system was developed. The model was validated using the experimental data and applied in five different climatic regions of the country for a complete year. The life-cycle cost of the system was estimated for each application. The results are compared to a conventional solar system, using a standard shell-and-tube heat exchanger. It is concluded that while thare is a performance advantage with a DCLLHE system over a conventional solar system, the advantage is not sufficiently large to overcome slightly higher capital and operating costs for the DCLLHE system.

  9. Evaluation of high performance evacuated tubular collectors in a residential heating and cooling system: Colorado State University Solar House I. Report for October 1, 1976--September 30, 1977

    Energy Technology Data Exchange (ETDEWEB)

    Duff, W.S.; Conway, T.M.; Loef, G.O.G.; Meredith, D.B.; Pratt, R.B.

    1978-03-01

    CSU Solar House I is configured with a prototype Corning evacuated tubular collector and a new Arkla lithium bromide water chiller designed for solar operation. Data have been collected for this configuration since January 1977. Prior to that time and since mid-1974, Solar House I has operated with a flat-plate collector and a previous Arkla LiBr air conditioner modified to operate in the lower solar temperature ranges. Project objectives were to develop an operating and control system for the new configuration and to compare the performance of the new residential solar heating, cooling, and hot water system with performance of the previous system. Many problems were encountered in the evolution of the operating and control systems due to the different operating characteristics of evacuated tubular collectors, such as their rapid thermal response and the possibility of much higher temperatures as compared to a flat-plate collector.

  10. Blood lipid, glucose and uric acid levels in patients with chronic spontaneous urticaria%慢性自发性荨麻疹患者血脂、空腹血糖与尿酸水平的测定

    Institute of Scientific and Technical Information of China (English)

    孙瑞凤; 齐婧; 连石; 朱威

    2016-01-01

    Serum triglyceride ( TG ) , total cholesterol ( TC ) , low density lipoprotein cholesterol ( LDL-C) , high density lipoprotein cholesterol ( HDL-C) , uric acid ( UA) levels and fasting blood glucose ( FBG) were measured in 67 patients with chronic spontaneous urticaria ( CSU ) and 66 healthy subjects ( controls).Results showed that the rates of increased serum TG and FBG levels in CSU patients were higher than those in controls ( 19% vs.6%,χ2 =5.309, P 0.05).The rate of rising FBG in CSU patients accompanied by angioedema(4/9)was higher than that in CSU patients without angioedema(7%,χ2 =7.181,P<0.05).%回顾分析2013年12月1日至2015年1月1日诊治的67例慢性自发性荨麻疹( CSU)患者的血清TG、TC、LDL-C、HDL-C、空腹血糖和尿酸水平,并与66例健康体检者比较。 CSU伴TG升高率(19%,13/67)高于对照组和空腹血糖升高率(12%,8/67)均高于对照组(6%,4/66;1%,1/66),差异均有统计学意义(χ2=5.309,P<0.05;χ2=4.194,P <0.05);CSU患者中 TC 升高率(7%,5/67)、LDL-C升高率(4%,3/67)、HDL-C降低率(6%,4/67)、尿酸升高率(6%,4/67),与对照组[3%(2/66)]、1%(1/66)、3%(2/66)、1%(1/66)]相比,差异均无统计学意义(均P>0.05)。 CSU伴发血管性水肿者的空腹血糖升高比例(4/9)高于CSU不伴发血管性水肿者(7%,4/58),差异有统计学意义(χ2=7.181,P<0.05)。提示CSU患者可伴有TG或空腹血糖升高,伴发血管性水肿者可伴有空腹血糖升高。

  11. Spatial and temporal distributions of ice nucleating particles during the Atmospheric Radiation Measurement (ARM) Cloud Aerosol Precipitation Experiment (ACAPEX)

    Science.gov (United States)

    Levin, E. J.; DeMott, P. J.; Suski, K. J.; Boose, Y.; Hill, T. C. J.; McCluskey, C. S.; Schill, G. P.; Duncan, D.; Al-Mashat, H.; Prather, K. A.; Sedlacek, A. J., III; Tomlinson, J. M.; Mei, F.; Hubbe, J. M.; Pekour, M. S.; Leung, L. R.; Kreidenweis, S. M.

    2016-12-01

    California is currently under drought conditions and changes in precipitation due to future climate change scenarios are uncertain. Thus, understanding the controlling factors for precipitation in this region, and having the capability to accurately model these scenarios, is important. A crucial area in understanding precipitation is in the interplay between atmospheric moisture and aerosols. Specifically, ice nucleation in clouds is an important process controlling precipitation formation. A major component of CA's yearly precipitation comes from wintertime atmospheric river (AR) events which were the focus of the 2015 Atmospheric Radiation Measurement (ARM) Cloud Aerosol Precipitation Experiment (ACAPEX) and CalWater 2 campaigns. These two campaigns provided sampling platforms on four aircraft, including the ARM Aerial Facility G-1, as well as the NOAA Ron Brown research vessel and at a ground station at Bodega Bay, CA. Measurements of ice nucleating particles (INPs) were made with the Colorado State University (CSU) Continuous Flow Diffusion Chamber (CFDC) aboard the G-1 and at Bodega Bay, and using aerosol filter collections on these platforms as well as the Ron Brown for post-processing via immersion freezing in the CSU Ice Spectrometer. Aerosol composition was measured aboard the G-1 with the Aerosol Time-of-Flight Mass Spectrometer (ATOFMS). Both the CFDC and ATOFMS sampled off of an isokinetic inlet when flying in clear air and a counter-flow virtual impactor in clouds to capture ice crystal and cloud droplet residuals. In this presentation we present ice nucleating particle concentrations before, during and after an AR event from air, ground and ocean-based measurements. We also examine INP concentration variability in orographic clouds and in clear air at altitude along the Sierra Nevada range, in the marine boundary layer and through the Central Valley, and relate these INP measurements to other aerosol physical and chemical properties.

  12. Device physics of thin-film polycrystalline cells and modules: Phase 1 annual report: February 1998--January 1999

    Energy Technology Data Exchange (ETDEWEB)

    Sites, J. R.

    1999-12-21

    This report describes work done by Colorado State University (CSU) during Phase 1 of this subcontract. CSU researchers continued to make basic measurements on CI(G)S and CdTe solar cells fabricated at different labs, to quantitatively deduce the loss mechanisms in these cells, and to make appropriate comparisons that illuminate where progress is being made. Cells evaluated included the new record CIGS cell, CIS cells made with and without CdS, and those made by electrodeposition and electroless growth from solution. Work on the role of impurities focused on sodium in CIS. Cells with varying amounts of sodium added during CIS deposition were fabricated at NREL using four types of substrates. The best performance was achieved with 10{sup {minus}2}--10{sup {minus}1} at% sodium, and the relative merits of proposed mechanisms for the sodium effect were compared. Researchers also worked on the construction and testing of a fine-focused laser-beam apparatus to measure local variations in polycrystalline cell performance. A 1{micro}m spot was achieved, spatial reproducibility in one and two dimensions is less than 1 {micro}m, and photocurrent is reliably measured when the 1{micro}m spot is reduced as low as 1-sun in intensity. In elevated-temperature stress tests, typical CdTe cells held at 100 C under illumination and normal resistive loads for extended periods of time were generally very stable; but those held under reverse or large forward bias and those contacted using larger amounts of copper were somewhat less stable. CdTe cell modeling produced reasonable fits to experimental data, including variations in back-contact barriers. A major challenge being addressed is the photovoltaic response of a single simple-geometry crystallite with realistic grain boundaries.

  13. Narrowband sodium lidar for the measurements of mesopause region temperature and wind.

    Science.gov (United States)

    Li, Tao; Fang, Xin; Liu, Wei; Gu, Sheng-Yang; Dou, Xiankang

    2012-08-01

    We report here a narrowband high-spectral resolution sodium temperature/wind lidar recently developed at the University of Science and Technology of China (USTC) in Hefei, China (31.5 °N, 117 °E). Patterned after the Colorado State University (CSU) narrowband sodium lidar with a dye laser-based transmitter, the USTC sodium temperature/wind lidar was deployed with a number of technical improvements that facilitate automation and ease of operation; these include a home constructed pulsed dye amplifier (PDA), a beam-steering system, a star-tracking program, and an electronic timing control. With the averaged power of ∼1.2 W output from PDA and the receiving telescope diameter of 0.76 m, our lidar system has a power aperture product of ∼0.55 Wm(2) and is comparable to the CSU and the University of Illinois at Urbana-Champaign (UIUC) sodium lidar systems. The uncertainties of typical measurements induced by photon noise and laser locking fluctuation for the temperature and wind with a 2 km vertical and 15 min temporal resolutions under the nighttime clear sky condition are estimated to be ∼1.0 K and ∼1.5 m/s, respectively, at the sodium peak (e.g., 91 km), and 8 K and 10 m/s, respectively, at both sodium layer edges (e.g., 81 km and 105 km). The USTC narrowband sodium lidar has been operated regularly during the night since November 2011. Using the initial data collected, we demonstrate the reliability and suitability of these high resolution and precision datasets for studying the wave perturbations in the mesopause region.

  14. NASA GRC Stirling Technology Development Overview

    Science.gov (United States)

    Thieme, Lanny G.; Schreiber, Jeffrey G.

    2003-01-01

    The Department of Energy, Lockheed Martin (LM), Stirling Technology Company, and NASA Glenn Research Center (GRC) are developing a high-efficiency Stirling Radioisotope Generator (SRG) for potential NASA Space Science missions. The SRG is being developed for multimission use, including providing spacecraft onboard electric power for NASA deep space missions and power for unmanned Mars rovers. NASA GRC is conducting an in- house supporting technology project to assist in developing the Stirling convertor for space qualification and mission implementation. Preparations are underway for a thermalhacuum system demonstration and unattended operation during endurance testing of the 55-We Technology Demonstration Convertors. Heater head life assessment efforts continue, including verification of the heater head brazing and heat treatment schedules and evaluation of any potential regenerator oxidation. Long-term magnet aging tests are continuing to characterize any possible aging in the strength or demagnetization resistance of the permanent magnets used in the linear alternator. Testing of the magnet/lamination epoxy bond for performance and lifetime characteristics is now underway. These efforts are expected to provide key inputs as the system integrator, LM, begins system development of the SRG. GRC is also developing advanced technology for Stirling convertors. Cleveland State University (CSU) is progressing toward a multi-dimensional Stirling computational fluid dynamics code, capable of modeling complete convertors. Validation efforts at both CSU and the University of Minnesota are complementing the code development. New efforts have been started this year on a lightweight convertor, advanced controllers, high-temperature materials, and an end-to-end system dynamics model. Performance and mass improvement goals have been established for second- and third-generation Stirling radioisotope power systems.

  15. Device Physics of Thin-Film Polycrystalline Cells and Modules; Final Subcontract Report; 6 December 1993-15 March 1998

    Energy Technology Data Exchange (ETDEWEB)

    Sites, J. R. (Department of Physics, Colorado State University, Ft. Collins, Colorado)

    1999-05-03

    This report describes work performed under this subcontract by Colorado State University (CSU). The results of the subcontract effort included progress in understanding CdTe and Cu(In1-xGax)Se2-based solar cells, in developing additional measurement and analysis techniques at the module level, and in strengthening collaboration within the thin-film polycrystalline solar-cell community. A major part of the CdTe work consisted of elevated-temperature stress tests to determine fabrication and operation conditions that minimize the possibility of long-term performance changes. Other CdTe studies included analysis of the back-contact junction, complete photon accounting, and the tradeoff with thin CdS between photocurrent gain and voltage loss. The Cu(In1-xGax)Se2 studies included work on the role of sodium in enhancing performance, the conditions under which conduction-band offsets affect cell performance, the transient effects of cycling between light and dark conditions, and detailed analysis of several individual series of cells. One aspect of thin-film module analysis has been addressing the differences in approach needed for relatively large individual cells made without grids. Most work, however, focused on analysis of laser-scanning data, including defect signatures, photocurrent/shunting separation, and the effects of forward bias or high-intensity light. Collaborations with other laboratories continued on an individual basis, and starting in 1994, collaboration was through the national R&D photovoltaic teams. CSU has been heavily involved in the structure and logistics of both the CdTe and CIS teams, as well as making frequent technical contributions in both areas.

  16. One-year safety and efficacy study of bilastine treatment in Japanese patients with chronic spontaneous urticaria or pruritus associated with skin diseases.

    Science.gov (United States)

    Yagami, Akiko; Furue, Masutaka; Togawa, Michinori; Saito, Akihiro; Hide, Michihiro

    2016-11-14

    A number of second-generation non-sedating antihistamines are used in clinical practices over the world. However, long-term safety and efficacy have not been proved high level evidence based medicine. We have performed an open-label, multicenter, phase III study to evaluate the long-term safety and efficacy of bilastine, a novel non-sedating H1 -antihistamine for patients with chronic spontaneous urticaria (CSU) or pruritus associated with skin diseases (trial registration no. JapicCTI-142528). Patients aged 18-74 years were treated with bilastine 20 mg once daily for up to 52 weeks. Safety and tolerability were assessed on the basis of adverse events (AE), bilastine-related AE, laboratory tests and vital signs. Efficacy was assessed based on rash score, itch score, overall improvement and quality of life. One hundred and ninety-eight patients enrolled, 122 of whom (61.6%) completed the 52-week treatment period. AE were reported in 64.5% and bilastine-related AE in 2.5% of patients throughout the 52-week treatment period. All AE were mild to moderate in severity. AE associated with the nervous system occurred in 10 patients (5.1%) including seven patients (3.6%) with headache. Somnolence reported in two of these patients (1.0%) was related to bilastine. All efficacy variables improved during treatment with bilastine. In conclusion, long-term treatment with bilastine 20 mg once daily for 52 weeks is safe and well tolerated in Japanese patients with CSU or pruritus associated with skin diseases. Bilastine improved disease symptoms of both conditions early in treatment, and the efficacy was maintained throughout the treatment.

  17. A prospective ten-year follow-up of patients with chronic urticaria.

    Science.gov (United States)

    Dionigi, P C L; Menezes, M C S; Forte, W C N

    2016-01-01

    Chronic urticaria can be the initial clinical presentation of a number of different diseases. The objective of the present study was to report the associated diseases during a ten-year clinical-laboratory follow-up in patients with an initial diagnosis of chronic spontaneous urticaria (CSU) of unknown cause. A prospective, longitudinal cohort study with a ten-year clinical-laboratory follow-up was conducted. Patients with a history of urticarial plaques of over six weeks presenting as the only clinical symptom were selected. Individuals with other clinical conditions, urticaria of known causes or chronic physical urticaria were excluded. The following tests were initially performed: haemogram, urine type I, stool parasite exam and sedimentation rate. The following exams were ordered during follow-up: PPD; urine culture; serology tests; antithyroid and antinuclear antibodies, rheumatoid factor, lupus anticoagulant; thyroid hormones; serum immunoglobulin; paranasal sinus and thorax radiographs; testing for BK and Helicobacter pylori; and prick tests. Infections were diagnosed in 29% of patients (syphilis, parasitosis, H. pylori, urinary infection, tuberculosis, hepatitis B and C); autoimmune diseases in 21% (thyroiditis, rheumatoid arthritis and antiphospholipid antibody syndrome); primary immunodeficiencies in 4% (IgA and IgG2 deficiencies); and chronic myeloid leukaemia in 1%. At ten-years of follow-up, the urticaria diagnosis was CSU of unknown cause in 45% of the cases. This ten-year clinical-laboratory follow-up of 100 individuals with chronic urticaria as the initial diagnosis revealed the presence of associated diseases in over half of the cases. The most prevalent diseases were infections and autoimmune diseases besides primary immunodeficiencies and blood diseases. Copyright © 2016 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.

  18. Efficacy and safety of bilastine in Japanese patients with chronic spontaneous urticaria: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II/III study.

    Science.gov (United States)

    Hide, Michihiro; Yagami, Akiko; Togawa, Michinori; Saito, Akihiro; Furue, Masutaka

    2017-04-01

    Bilastine, a novel non-sedating second-generation H1-antihistamine, has been widely used in the treatment of allergic rhinoconjunctivitis and urticaria with a recommended dose of 20 mg once daily in most European countries since 2010. We evaluated its efficacy and safety in Japanese patients with chronic spontaneous urticaria (CSU). We conducted a multicenter, randomized, double-blind, placebo-controlled phase II/III study (trial registration No. JapicCTI-142574). Patients (age, 18-74 years) were randomly assigned to receive bilastine 20 mg, 10 mg or placebo once daily for 2 weeks. The primary efficacy endpoint was the change from baseline (Day -3 to 0) in total symptom score (TSS) at 2 weeks (Day 8-14), consisting of the itch and rash scores. A total of 304 patients were randomly allocated to bilastine 20 mg (101 patients), bilastine 10 mg (100 patients), and placebo (103 patients). The changes in TSS at 2 weeks were significantly decreased by bilastine 20 mg than did placebo (p < 0.001), demonstrating the superiority of bilastine 20 mg. Bilastine 10 mg also showed a significant difference from placebo (p < 0.001). The TSS changes for the bilastine showed significant improvement from Day 1, and were maintained during the treatment period. The Dermatology Life Quality Index scores were also improved in bilastine than in placebo. The bilastine treatments were safe and well tolerated. Two-week treatment with bilastine (20 or 10 mg) once daily was effective and tolerable in Japanese patients with CSU, demonstrating an early onset of action. Copyright © 2016 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved.

  19. Clinical practice guideline for diagnosis and management of urticaria.

    Science.gov (United States)

    Kulthanan, Kanokvalai; Tuchinda, Papapit; Chularojanamontri, Leena; Chanyachailert, Pattriya; Korkij, Wiwat; Chunharas, Amornsri; Wananukul, Siriwan; Limpongsanurak, Wanida; Benjaponpitak, Suwat; Wisuthsarewong, Wanee; Aunhachoke, Kobkul; Wessagowit, Vesarat; Chatchatee, Pantipa; Wattanakrai, Penpun; Jirapongsananuruk, Orathai; Klaewsongkram, Jettanong; Noppakun, Nopadon; Vichyanond, Pakit; Suthipinittharm, Puan; Ruxrungtham, Kiat; Singalavanija, Srisupalak; Ngamphaiboon, Jarungchit

    2016-09-01

    Urticaria is a common skin condition that can compromise quality of life and may affect individual performance at work or school. Remission is common in majority of patients with acute spontaneous urticaria (ASU); however, in chronic cases, less than 50% had remission. Angioedema either alone or with urticaria is associated with a much lower remission rate. Proper investigation and treatment is thus required. This guideline, a joint development of the Dermatological Society of Thailand, the Allergy, Asthma, and Immunology Association of Thailand and the Pediatric Dermatological Society of Thailand, is graded and recommended based on published evidence and expert opinion. With simple algorithms, it is aimed to help guiding both adult and pediatric physicians to better managing patients who have urticaria with/without angioedema. Like other recent guideline, urticaria is classified into spontaneous versus inducible types. Patients present with angioedema or angioedema alone, drug association should be excluded, acetyl esterase inhibitors (ACEIs) and non-steroidal anti-inflammatory drugs (NSAIDs) in particular. Routine laboratory investigation is not cost-effective in chronic spontaneous urticaria (CSU), unless patients have clinical suggesting autoimmune diseases. Non-sedating H1-antihistamine is the first-line treatment for 2-4 weeks; if urticaria was not controlled, increasing the dose up to 4 times is recommended. Sedating first-generation antihistamines have not been proven more advantage than non-sedating antihistamines. The only strong evidence-based alternative regimen for CSU is an anti-IgE: omalizumab; due to very high cost it however might not be accessible in low-middle income countries. Non-pharmacotherapeutic means to minimize hyper-responsive skin are also important and recommended, such as prevention skin from drying, avoidance of hot shower, scrubbing, and excessive sun exposure.

  20. A new trilocus sequence-based multiplex-PCR to detect major Acinetobacter baumannii clones.

    Science.gov (United States)

    Martins, Natacha; Picão, Renata Cristina; Cerqueira-Alves, Morgana; Uehara, Aline; Barbosa, Lívia Carvalho; Riley, Lee W; Moreira, Beatriz Meurer

    2016-08-01

    A collection of 163 Acinetobacter baumannii isolates detected in a large Brazilian hospital, was potentially related with the dissemination of four clonal complexes (CC): 113/79, 103/15, 109/1 and 110/25, defined by University of Oxford/Institut Pasteur multilocus sequence typing (MLST) schemes. The urge of a simple multiplex-PCR scheme to specify these clones has motivated the present study. The established trilocus sequence-based typing (3LST, for ompA, csuE and blaOXA-51-like genes) multiplex-PCR rapidly identifies international clones I (CC109/1), II (CC118/2) and III (CC187/3). Thus, the system detects only one (CC109/1) out of four main CC in Brazil. We aimed to develop an alternative multiplex-PCR scheme to detect these clones, known to be present additionally in Africa, Asia, Europe, USA and South America. MLST, performed in the present study to complement typing our whole collection of isolates, confirmed that all isolates belonged to the same four CC detected previously. When typed by 3LST-based multiplex-PCR, only 12% of the 163 isolates were classified into groups. By comparative sequence analysis of ompA, csuE and blaOXA-51-like genes, a set of eight primers was designed for an alternative multiplex-PCR to distinguish the five CC 113/79, 103/15, 109/1, 110/25 and 118/2. Study isolates and one CC118/2 isolate were blind-tested with the new alternative PCR scheme; all were correctly clustered in groups of the corresponding CC. The new multiplex-PCR, with the advantage of fitting in a single reaction, detects five leading A. baumannii clones and could help preventing the spread in healthcare settings.

  1. Characterization of a two-component regulatory system from Acinetobacter baumannii that controls biofilm formation and cellular morphology.

    Science.gov (United States)

    Tomaras, Andrew P; Flagler, Michael J; Dorsey, Caleb W; Gaddy, Jennifer A; Actis, Luis A

    2008-11-01

    Acinetobacter baumannii forms biofilms on abiotic surfaces, a phenotype that may explain its ability to survive in nosocomial environments and to cause device-related infections in compromised patients. The biofilm proficiency of the 19606 type strain depends on the production of pili, cell-surface appendages assembled via the CsuAB-A-B-C-D-E chaperone-usher secretion system. The screening of a bank of isogenic insertion derivatives led to the identification of a biofilm-deficient derivative in which a transposon insertion disrupted a gene predicted to encode the response regulator of a two-component regulatory system. This gene, which was named bfmR, is required for the expression of the Csu pili chaperone-usher assembly system. This coding region is followed by an ORF encoding a putative sensor kinase that was named bfmS, which plays a less relevant role in biofilm formation when cells are cultured in rich medium. Further examination showed that the bfmR mutant was capable of attaching to abiotic surfaces, although to levels significantly lower than those of the parental strain, when it was cultured in a chemically defined minimal medium. Additionally, the morphology of planktonic cells of this mutant, when grown in minimal medium, was drastically affected, while adherent mutant cells were indistinguishable in shape and size from the parental strain. Together, these results indicate that BfmR is part of a two-component regulatory system that plays an important role in the morphology of A. baumannii 19606 cells and their ability to form biofilms on abiotic surfaces.

  2. Technology-Driven and Innovative Training for Sustainable Agriculture in The Face of Climate Change

    Science.gov (United States)

    Wishart, D. N.

    2015-12-01

    Innovative training in 'Sustainable Agriculture' for an increasingly STEM-dependent agricultural sector will require a combination of approaches and technologies for global agricultural production to increase while offsetting climate change. Climate change impacts the water resources of nations as normal global weather patterns are altered during El Nino events. Agricultural curricula must incorporate awareness of 'climate change' in order to find novel ways to (1) assure global food security; (2) improve soil productivity and conservation; (3) improve crop yields and irrigation; (4) inexpensively develop site specific principles of crop management based on variable soil and associated hydrological properties; and (5) improve precision farming. In February 2015, Central State University (CSU), Ohio became an 1890 Land-Grant institution vital to the sustainability of Ohio's agricultural sector. Besides agricultural extension, the agriculture curriculum at CSU integrates multidisciplinary courses in science, technology engineering, agriculture, and mathematics (STEAM). The agriculture program could benefit from a technology-driven, interdisciplinary soil science course that promotes climate change education and climate literacy while being offered in both a blended and collaborative learning environment. The course will focus on the dynamics of microscale to mesoscale processes occurring in farming systems, those of which impact climate change or could be impacted by climate change. Elements of this course will include: climate change webinars; soil-climate interactions; carbon cycling; the balance of carbon fluxes between soil storage and atmosphere; microorganisms and soil carbon storage; paleoclimate and soil forming processes; geophysical techniques used in the characterization of soil horizons; impact of climate change on soil fertility; experiments; and demonstrations.

  3. Vesalius project: interactive computers in anatomical instruction

    Science.gov (United States)

    McCracken, Thomas O.; Roper, Stephen D.; Spurgeon, Thomas L.

    1991-04-01

    This project is based on an entirely new concept for teaching the structure and function of the human body a concept which combines traditional approaches gained from centuries of study of human anatomy with the most recent sophisticated 3-dimensional computer graphics display systems and laser disc technology. The end-point of the project is a high resolution interactive 3-D atlas of human/animal anatomy stored on a laser video disc and displayed on graphics workstations--an " electronic Gray''s Anatomy" . These displays will be used to teach the structure of the body and to give students and instructors an understanding of their own body in health and disease. To evaluate the software developed undergraduate students from the anatomy courses at CSU wil be allowed to work with the computer-generated images from the earliest stages of development. Feedback from these students will be incorporated into the software development. Furthermore once a relatively complete series of images has been generated groups of students will be selected at random to study anatomy with this new methodology and will be compared with control groups who utilize more traditional techniques. METHODOLOGY This is a complex project that requires many individual facets to be developed simultaneously (figure 1). We have established an important collaboration with the Uniformed Services University in Bethesda that will allow us to utilize a large cryotome with photographic systems and the expertise to operate it already available there. Indeed most of the elaborate apparatus such as graphics workstations needed for the project is currently available either at CSU or through collaborative arrangements with other institutions.

  4. Hirshfeld atom refinement.

    Science.gov (United States)

    Capelli, Silvia C; Bürgi, Hans-Beat; Dittrich, Birger; Grabowsky, Simon; Jayatilaka, Dylan

    2014-09-01

    Hirshfeld atom refinement (HAR) is a method which determines structural parameters from single-crystal X-ray diffraction data by using an aspherical atom partitioning of tailor-made ab initio quantum mechanical molecular electron densities without any further approximation. Here the original HAR method is extended by implementing an iterative procedure of successive cycles of electron density calculations, Hirshfeld atom scattering factor calculations and structural least-squares refinements, repeated until convergence. The importance of this iterative procedure is illustrated via the example of crystalline ammonia. The new HAR method is then applied to X-ray diffraction data of the dipeptide Gly-l-Ala measured at 12, 50, 100, 150, 220 and 295 K, using Hartree-Fock and BLYP density functional theory electron densities and three different basis sets. All positions and anisotropic displacement parameters (ADPs) are freely refined without constraints or restraints - even those for hydrogen atoms. The results are systematically compared with those from neutron diffraction experiments at the temperatures 12, 50, 150 and 295 K. Although non-hydrogen-atom ADPs differ by up to three combined standard uncertainties (csu's), all other structural parameters agree within less than 2 csu's. Using our best calculations (BLYP/cc-pVTZ, recommended for organic molecules), the accuracy of determining bond lengths involving hydrogen atoms from HAR is better than 0.009 Å for temperatures of 150 K or below; for hydrogen-atom ADPs it is better than 0.006 Å(2) as judged from the mean absolute X-ray minus neutron differences. These results are among the best ever obtained. Remarkably, the precision of determining bond lengths and ADPs for the hydrogen atoms from the HAR procedure is comparable with that from the neutron measurements - an outcome which is obtained with a routinely achievable resolution of the X-ray data of 0.65 Å.

  5. The 331 Model with RH Neutrinos and Associated ZH Production at High Energy e+ e- Collider%伴有右手中微子的331模型与高能e+e-对撞机上ZH的产生

    Institute of Scientific and Technical Information of China (English)

    崔小敏; 刘要北

    2008-01-01

    在伴有右手中中微子的SU(3)CSU(3)L?U(1)X(331)模型框架内讨论了Higgs粒子产生过程e+e-→ZH.结果表明,当新粒子Z′的质量接近质心能量时能对该过程产生明显的修正.在该模型合理的参数空间内,过程e+e-→ZH的总产生截面σ与标准模型(SM)相应值的偏差大于5%,应该能在未来的高能直线对撞机实验中观测到.%In the context of SU(3)C?SU(3)L?U(1)X(331) model with right-handed (RH) neutrinos, we study the Higgsstrahlung process e+e-→ZH and calculate the cross section of this process at leading order. Our numerical results shown that the production cross sections for this process can be significantly large as MZ~√S. With reasonable values of the Z' mass MZ, the deviation of the total production cross sectiou σtolfrom its SM value is larger than 5%, which might be detected in the future high energy linear e+e- collider (LC) experiments. The future LC experiments could test the 331 model with RH neutrinos by measuring the cross section of the process e+e-→ZH.

  6. Identity of Innovative Multifunctional Material Manufacturing Business in Latvia / Inovatīvu Daudzfunkcionālo Materiālu Ražotāju Identitāte Latvijā

    Directory of Open Access Journals (Sweden)

    Geipele I.

    2015-08-01

    Full Text Available Publikācija sniedz veiktā zinātniski praktiskā pētījuma rezultātus, kura ietvaros tika noteikts Latvijas inovatīvu daudzfunkcionālo materiālu ražotāju darbības profils un identitāte. Pētījumā tika izmantota kompleksās analīzes metode, kas ietvēra ekspertu intervijas, uzņēmumu oficiāli reģistrēto datu kvalitatīvo analīzi, zinātniski praktisko aptauju, kā arī pētāmo uzņēmumu finanšu darbības rezultātu analīzi. Zinātniskais darbs sniedz izsmeļošu informāciju par mērķa uzņēmumu tehnoloģisko profilu un pēta, vai Latvijas mērķa ražošanas nozarē ir sinerģijas vai sīvās konkurences pazīmes. Šim zinātniskajam pētījumam ir noteikta aktualitāte saskaņā ar tā unikalitāti Latvijas valsts mērogā un atbilstība Viedās specializācijas stratēģijai. Pētījuma galvenie secinājumi ir saistīti ar uzņēmumu produkcijas komercializācijas ietekmējošo faktoru apzināšanu, sasniegtajiem finansiālajiem rezultātiem un plānotajiem attīstības virzieniem.

  7. Partial Closure Report for the Area 514 Treatment and Storage Facility

    Energy Technology Data Exchange (ETDEWEB)

    Abri, M

    2005-05-02

    The purpose of this partial closure report is to inform the Department of Toxic Substances Control (DTSC) of the status of final closure of the Area 514 Treatment and Storage Facility (Area 514) and fulfill the DTSC requirements to proceed with the implementation of the interim action. Area 514 is located at the Livermore main site of Lawrence Livermore National Laboratory (LLNL). LLNL is owned by the U.S. Department of Energy (DOE) and operated jointly by DOE and the University of California. LLNL received its permit to operate hazardous waste facilities from DTSC in 1997. The hazardous waste treatment and storage operations of Area 514 were transferred to a newly constructed complex, the Decontamination and Waste Treatment Facility (DWTF), in 2003. Once the DWTF was operational, the final closure of Area 514 began in accordance with the DTSC-approved closure plan in June 2004. Abri Environmental Engineering, Inc., was retained by LLNL to observe the A514 closure process and prepare this partial closure report and certification. Prior to closure, the configuration of the Area 514 Treatment and Storage Facility consisted of Building 514, the Area 514-1 Container Storage and Treatment unit, the Area 514-2 Container Storage Unit (CSU), the Area 514-3 CSU, Building 513, the Wastewater Treatment Tank Farm unit, and the associated Area 514 yard area. The fenced area of Area 514 included approximately 27,350 ft2 on the LLNL Livermore site. To date, except for the 514-3 CSU, all of the other Area 514 structures have been demolished; and sampling and analysis have taken place. The non-hazardous wastes have been disposed of. At the time of writing this report, the hazardous, mixed, and low-level radioactive wastes are in the process of profiling for final disposition. Once the disposition of all wastes has been finalized, the implementation of the approved closure plan will be completed. As a part of the closure process, LLNL is required to submit a closure report and a

  8. STAR - Research Experiences at National Laboratory Facilities for Pre-Service and Early Career Teachers

    Science.gov (United States)

    Keller, J. M.; Rebar, B.; Buxner, S.

    2012-12-01

    The STEM Teacher and Researcher (STAR) Program provides pre-service and beginning teachers the opportunity to develop identity as both teachers and researchers early in their careers. Founded and implemented by the Center for Excellence in Science and Mathematics Education (CESaME) at California Polytechnic State University on behalf of the California State University (CSU) system, STAR provides cutting edge research experiences and career development for students affiliated with the CSU system. Over the past three summers, STAR has also partnered with the NSF Robert Noyce Teacher Scholarship Program to include Noyce Scholars from across the country. Key experiences are one to three summers of paid research experience at federal research facilities associated with the Department of Energy (DOE), National Aeronautics and Space Administration (NASA), National Oceanic and Atmospheric Association (NOAA), and the National Optical Astronomy Observatory (NOAO). Anchoring beginning teachers in the research community enhances participant understanding of what it means to be both researchers and effective teachers. Since its inception in 2007, the STAR Program has partnered with 15 national lab facilities to provide 290 research experiences to 230 participants. Several of the 68 STAR Fellows participating in the program during Summer 2012 have submitted abstracts to the Fall AGU Meeting. Through continued partnership with the Noyce Scholar Program and contributions from outside funding sources, the CSU is committed to sustaining the STAR Program in its efforts to significantly impact teacher preparation. Evaluation results from the program continue to indicate program effectiveness in recruiting high quality science and math majors into the teaching profession and impacting their attitudes and beliefs towards the nature of science and teaching through inquiry. Additionally, surveys and interviews are being conducted of participants who are now teaching in the classroom as

  9. NASA Multidimensional Stirling Convertor Code Developed

    Science.gov (United States)

    Tew, Roy C.; Thieme, Lanny G.

    2004-01-01

    A high-efficiency Stirling Radioisotope Generator (SRG) for use on potential NASA Space Science missions is being developed by the Department of Energy, Lockheed Martin, Stirling Technology Company, and the NASA Glenn Research Center. These missions may include providing spacecraft onboard electric power for deep space missions or power for unmanned Mars rovers. Glenn is also developing advanced technology for Stirling convertors, aimed at substantially improving the specific power and efficiency of the convertor and the overall power system. Performance and mass improvement goals have been established for second- and third-generation Stirling radioisotope power systems. Multiple efforts are underway to achieve these goals, both in house at Glenn and under various grants and contracts. These efforts include the development of a multidimensional Stirling computational fluid dynamics code, high-temperature materials, advanced controllers, an end-to-end system dynamics model, low-vibration techniques, advanced regenerators, and a lightweight convertor. Under a NASA grant, Cleveland State University (CSU) and its subcontractors, the University of Minnesota (UMN) and Gedeon Associates, have developed a twodimensional computer simulation of a CSUmod Stirling convertor. The CFD-ACE commercial software developed by CFD Research Corp. of Huntsville, Alabama, is being used. The CSUmod is a scaled version of the Stirling Technology Demonstrator Convertor (TDC), which was designed and fabricated by the Stirling Technology Company and is being tested by NASA. The schematic illustrates the structure of this model. Modeled are the fluid-flow and heat-transfer phenomena that occur in the expansion space, the heater, the regenerator, the cooler, the compression space, the surrounding walls, and the moving piston and displacer. In addition, the overall heat transfer, the indicated power, and the efficiency can be calculated. The CSUmod model is being converted to a two

  10. Can Skateboarding Save the Planet? A Curricular Unit on Global Climate Change Developed Through the NASA LIFT-OFF Program

    Science.gov (United States)

    Pruett, L. E.; Burrell, S.; Chidester, C.; Metzger, E. P.

    2010-12-01

    The inclusion of global climate change education in California public high schools is constrained by several factors, including the planning time needed to effectively correlate state content standards to the multidisciplinary science of climate change, the lack of time in the curriculum, and budget constraints that limit resources for teachers. Recent efforts by the NASA LIFT-OFF program to support classroom teachers in the development of inquiry-based curricular materials have helped to alleviate many of these burdens. NASA LIFT-OFF is funded by a grant to the Alameda County Office of Education and involves a partnership between the Alameda, Santa Clara, and Los Angeles county offices of education and science faculty at California State University (CSU) East Bay, San Jose State University (SJSU), and Cal Poly Pomona. LIFT-OFF goals are to improve high school science teachers’ content knowledge through interactions with scientists from the CSU campuses, NASA, and the SETI Institute and to enhance their ability to plan and implement high-quality science inquiry in their classrooms. LIFT-OFF teachers at the three CSU campuses are developing instructional cases that use NASA resources and research-based pedagogical practices to explore engaging real-world questions. We participated in SJSU’s 2010 LIFT-OFF summer institute and worked as a team to develop a 12-day unit for high school students that focuses on the science behind global climate change. In addition to delivering science content, the unit engages students in critical thinking and evaluation. Students generate, access and interpret data, and use the knowledge gained to make small lifestyle changes that aid in the reduction of their greenhouse gas emissions. Not only does this unit of study empower students to make science-based decisions, it also incorporates diverse learning strategies, such as the use of visuals aids, language acquisition techniques to improve literacy, formative assessments and daily

  11. Forest Watch: Using Student Data to Monitor Forest Response to Ground-Level Ozone

    Science.gov (United States)

    Spencer, S.; Rock, B. N.

    2006-12-01

    Forest Watch, a k-12 science outreach program begun at the University of New Hampshire (UNH) in 1991, has engaged pre-college students in providing UNH researchers with data on the annual response of white pine (Pinus strobus; a bio-indicator species for ozone exposure) to ground-level ozone across the New England region. Each year, student-collected growth and foliar symptomology data for 5 pine trees adjacent to their schools, along with first-year foliar samples, are submitted to UNH. Key foliar symptoms and student data are compared with summer monthly (JJA) maximum ozone concentrations collected by state and federal ozone monitoring stations across the region. To date, tree health indicators are inversely correlated (r2=0.83;p=0.10) with ozone concentrations: low ozone levels correlate with symptoms of good health (spectral indices diagnostic of high foliar chlorophyll levels and moisture content, normal incremental growth, low number of foliar symptoms), while summers characterized by high ozone concentrations correlate with symptoms of reduced health (low chlorophyll indices and moisture content, reduced incremental growth, increased number of foliar symptoms). In drought years (1999, 2001, 2002, 2003) few foliar symptoms of ozone damage are seen even though ozone levels were high, likely due to drought-induced stomatal closure. Based on student data since 1998, either low ozone summers, or drought summers have resulted in improved health in the sampled trees (n=30). Based on the success of Forest Watch in New England, we are exploring the extension of the program to Colorado as Front Range Forest Watch, operated from Colorado State University (CSU). The primary objective is to develop a student-scientist-local agency project that addresses real ecological issues in northern Colorado, including ozone pollution, and to provide pre-college students and teachers authentic science experiences. CSU runs a GK-12 program with Poudre School District in northern

  12. Trace Gas Exchange of Biofuel Crops

    Science.gov (United States)

    Graus, M.; Warneke, C.; Williams, E. J.; Lerner, B. M.; Gilman, J. B.; Li, R.; Eller, A. S.; Gray, C.; Fierer, N.; Fall, R.; Harley, P. C.; Roberts, J. M.; Yuan, B.; Qian, Y.; Westra, P.; Fryrear, C.; Collins, M.; Whitman, K.; De Gouw, J. A.

    2011-12-01

    In 2010 leaf level gas exchange and VOC fluxes from switchgrass and corn grown at the CSU horticultural farm in Ft Collins (CO) were measured using a PTR-MS coupled to a modified Li6400 cuvette system. Both species are C4 plants with corn currently being the dominant biofuel crop in the USA whilst switchgrass being a promising candidate for cellulosic fuel ethanol production. Amongst the strongest VOC emissions from both plants were methanol, acetic acid, acetaldehyde, acetone and toluene. The switchgrass VOC emissions compare reasonably well with the only published data measured from potted plants in a whole plant enclosure (Eller et al. 2011). VOC emission studies on corn are almost as scarce as those of switchgrass. Considering the acreage of corn grown in the USA every year, VOC flux measurements of this plant species are largely under-represented in the literature. The emission rates that do exist in the literature do not compare well with the numbers found in this study (e.g. Das et al. 2003; 35μg methanol per hour per gram biomass). To investigate the biosphere atmosphere exchange of corn fields in more detail the field campaign BioCORN 2011 was initiated. In summer 2011 an eddy covariance system was set up in a corn field at ARDEC (CSU, Ft Collins, CO) to investigate the energy flux and the trace gas exchange of the US' dominant biofuel crop. Besides energy flux, evapotranspiration and CO2 flux a comprehensive suite of volatile organic compounds and inorganic species (O3, NO, NO2, CO) are measured for virtual disjunct eddy covariance (vDEC) analysis and true eddy covariance (EC) fluxes, respectively. VOCs are monitored by PTR-MS and, for the first time, fluxes of formic acid are measured utilizing NI-CIMS data for vDEC analysis. Besides the EC approach leaf level flux measurements and soil flux measurements are performed using a GC-MS system (TACOH) coupled to a modified Li6400 system and to soil chambers, respectively. Ethanol and methanol are amongst the

  13. Co-occurrence of blaNDM-1 with blaOXA-23 or blaOXA-58 in clinical multidrug-resistant Acinetobacter baumannii isolates in Algeria.

    Science.gov (United States)

    Ramoul, Abir; Loucif, Lotfi; Bakour, Sofiane; Amiri, Sabrina; Dekhil, Mazouz; Rolain, Jean-Marc

    2016-09-01

    The aim of this study was to characterise the mechanisms of carbapenem resistance in Acinetobacter baumannii strains isolated in an Algerian hospital. A total of 43 imipenem-resistant A. baumannii clinical isolates collected between 2010 and 2013 were identified using API 20NE and were confirmed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF/MS). Antibiotic susceptibility testing was performed by the disk diffusion and Etest methods. Carbapenemase activity was detected using microbiological tests and PCR. Genetic transfer of the blaNDM-1 gene was performed by conjugation using sodium azide-resistant Escherichia coli J53 as recipient strain. Clonal relationships were studied by multilocus sequence typing (MLST) using partial sequences of the csuE and blaOXA-51 genes. All 43 A. baumannii isolates were resistant to imipenem with high minimum inhibitory concentrations (MICs) (>32μg/mL). The strains harboured blaOXA-23, blaNDM-1, blaOXA-58 and/or blaOXA-24 genes. Co-existence of blaNDM-1 and blaOXA-23 or blaOXA-58 was detected in two isolates and one isolate, respectively. NDM-1 plasmid transfer to E. coli J53 was successful only for one of the three strains harbouring both blaNDM-1 and blaOXA-23 or blaOXA-58. The phylogenetic tree obtained from concatenation of the partial sequences of csuE and blaOXA-51 showed that there was no genetic relationship between the isolates and the blaNDM-1 resistance gene. Here we report for the first time the co-occurrence of blaNDM-1 along with blaOXA-23 or blaOXA-58 in recent clinical isolates of A. baumannii from Northeast Algeria. These findings re-emphasise the dissemination and rapid spread of blaNDM-1 carbapenemase genes in multidrug-resistant clinical A. baumannii isolates in Algeria.

  14. Simulating the 2012 High Plains drought using three single column versions (SCM) of BUGS5

    Science.gov (United States)

    Medina, I. D.; Denning, S.

    2013-12-01

    The impact of changes in the frequency and severity of drought on fresh water sustainability is a great concern for many regions of the world. One such location is the High Plains, where the local economy is primarily driven by fresh water withdrawals from the Ogallala Aquifer, which accounts for approximately 30% of total irrigation withdrawals from all U.S. aquifers combined. Modeling studies that focus on the feedback mechanisms that control the climate and eco-hydrology during times of drought are limited, and have used conventional General Circulation Models (GCMs) with grid length scales ranging from one hundred to several hundred kilometers. Additionally, these models utilize crude statistical parameterizations of cloud processes for estimating sub-grid fluxes of heat and moisture and have a poor representation of land surface heterogeneity. For this research, we will focus on the 2012 High Plains drought and will perform numerical simulations using three single column versions (SCM) of BUGS5 (Colorado State University (CSU) GCM coupled to the Simple Biosphere Model (SiB3)) at multiple sites overlying the Ogallala Aquifer for the 2011-2012 periods. In the first version of BUGS5, the model will be used in its standard bulk setting (single atmospheric column coupled to a single instance of SiB3), secondly, the Super-Parameterized Community Atmospheric Model (SP-CAM), a cloud resolving model (CRM consists of 64 atmospheric columns), will replace the single CSU GCM atmospheric parameterization and will be coupled to a single instance of SiB3, and for the third version of BUGS5, an instance of SiB3 will be coupled to each CRM column of the SP-CAM (64 CRM columns coupled to 64 instances of SiB3). To assess the physical realism of the land-atmosphere feedbacks simulated at each site by all versions of BUGS5, differences in simulated energy and moisture fluxes will be computed between the 2011 and 2012 period and will be compared to differences calculated using

  15. Clouds, weather, climate, and modeling for K-12 and public audiences from the Center for Multi-scale Modeling of Atmospheric Processes

    Science.gov (United States)

    Foster, S. Q.; Johnson, R. M.; Randall, D. A.; Denning, A.; Russell, R. M.; Gardiner, L. S.; Hatheway, B.; Jones, B.; Burt, M. A.; Genyuk, J.

    2010-12-01

    The need for improving the representation of cloud processes in climate models has been one of the most important limitations of the reliability of climate-change simulations. Now in its fifth year, the National Science Foundation-funded Center for Multi-scale Modeling of Atmospheric Processes (CMMAP) at Colorado State University (CSU) is addressing this problem through a revolutionary new approach to representing cloud processes on their native scales, including the cloud-scale interaction processes that are active in cloud systems. CMMAP has set ambitious education and human-resource goals to share basic information about the atmosphere, clouds, weather, climate, and modeling with diverse K-12 and public audiences. This is accomplished through collaborations in resource development and dissemination between CMMAP scientists, CSU’s Little Shop of Physics (LSOP) program, and the Windows to the Universe (W2U) program at University Corporation for Atmospheric Research (UCAR). Little Shop of Physics develops new hands on science activities demonstrating basic science concepts fundamental to understanding atmospheric characteristics, weather, and climate. Videos capture demonstrations of children completing these activities which are broadcast to school districts and public television programs. CMMAP and LSOP educators and scientists partner in teaching a summer professional development workshops for teachers at CSU with a semester's worth of college-level content on the basic physics of the atmosphere, weather, climate, climate modeling, and climate change, as well as dozens of LSOP inquiry-based activities suitable for use in classrooms. The W2U project complements these efforts by developing and broadly disseminating new CMMAP-related online content pages, animations, interactives, image galleries, scientists’ biographies, and LSOP videos to K-12 and public audiences. Reaching nearly 20 million users annually, W2U is highly valued as a curriculum enhancement

  16. Hands-on, online, and workshop-based K-12 weather and climate education resources from the Center for Multi-scale Modeling of Atmospheric Processes

    Science.gov (United States)

    Foster, S. Q.; Johnson, R. M.; Randall, D. A.; Denning, A.; Burt, M. A.; Gardiner, L.; Genyuk, J.; Hatheway, B.; Jones, B.; La Grave, M. L.; Russell, R. M.

    2009-12-01

    The need for improving the representation of cloud processes in climate models has been one of the most important limitations of the reliability of climate-change simulations. Now in its fourth year, the National Science Foundation-funded Center for Multi-scale Modeling of Atmospheric Processes (CMMAP) at Colorado State University (CSU) is addressing this problem through a revolutionary new approach to representing cloud processes on their native scales, including the cloud-scale interaction processes that are active in cloud systems. CMMAP has set ambitious education and human-resource goals to share basic information about the atmosphere, clouds, weather, climate, and modeling with diverse K-12 and public audiences. This is accomplished through collaborations in resource development and dissemination between CMMAP scientists, CSU’s Little Shop of Physics (LSOP) program, and the Windows to the Universe (W2U) program at University Corporation for Atmospheric Research (UCAR). Little Shop of Physics develops new hands on science activities demonstrating basic science concepts fundamental to understanding atmospheric characteristics, weather, and climate. Videos capture demonstrations of children completing these activities which are broadcast to school districts and public television programs. CMMAP and LSOP educators and scientists partner in teaching a summer professional development workshops for teachers at CSU with a semester's worth of college-level content on the basic physics of the atmosphere, weather, climate, climate modeling, and climate change, as well as dozens of LSOP inquiry-based activities suitable for use in classrooms. The W2U project complements these efforts by developing and broadly disseminating new CMMAP-related online content pages, animations, interactives, image galleries, scientists’ biographies, and LSOP videos to K-12 and public audiences. Reaching nearly 20 million users annually, W2U is highly valued as a curriculum enhancement

  17. IMPROVEMENT TO PIPELINE COMPRESSOR ENGINE RELIABILITY THROUGH RETROFIT MICRO-PILOT IGNITION SYSTEM -- PHASE III

    Energy Technology Data Exchange (ETDEWEB)

    Scott Chase; Daniel Olsen; Ted Bestor

    2005-03-01

    This report documents the third year's effort towards a 3-year program conducted by the Engines & Energy Conversion Laboratory (EECL) at Colorado State University (CSU) to develop micropilot ignition systems for existing pipeline compressor engines. Research activities for the overall program were conducted with the understanding that the efforts are to result in a commercial product to capture and disseminate the efficiency and environmental benefits of this new technology. Commercially-available fuel injection products were identified and applied to the program where appropriate. This approach will minimize the overall time-to-market requirements, while meeting performance and cost criteria. Two earlier phases of development precede this report. The objective for Phase I was to demonstrate the feasibility of retrofit micropilot ignition (RMI) systems for large bore, slow speed engines operating at low compression ratios under laboratory conditions at the EECL. The objective for Phase II was to further develop and optimize the micropilot ignition system at the EECL for large bore, slow speed engines operating at low compression ratios. These laboratory results were enhanced, then verified via a field demonstration project during Phase III of the Micropilot Ignition program. An Implementation Team of qualified engine retrofit service providers was assembled to install the retrofit micropilot ignition system for an engine operated by El Paso Pipeline Group at a compressor station near Window Rock, Arizona. Testing of this demonstration unit showed that the same benefits identified by laboratory testing at CSU, i.e., reduced fuel consumption and exhaust emissions (NOx, THC, CO, and CH2O). Installation efforts at Window Rock were completed towards the end of the budget period, which did not leave sufficient time to complete the durability testing. These efforts are ongoing, with funding provided by El Paso Pipeline Group, and the results will be documented in a

  18. IgE FcɛR1β polymorphism and risk of developing chronic spontaneous urticaria: A study in an ethnic Kashmiri population.

    Science.gov (United States)

    Rasool, R; Shera, I A; Nissar, S; Yousuf, Q; Shah, Z A

    2015-01-01

    The pathogenesis of chronic spontaneous urticaria involves interplay between the genetic and environmental factors, most of which is still poorly understood. It is well-recognized that 30-40% of chronic spontaneous urticaria is autoimmune in nature. Chronic autoimmune urticaria is caused by anti-FcɛR1β and less frequently, by anti-IgE auto antibodies that lead to mast cell and basophil activation, thereby giving rise to the release of histamine and other proinflammatory mediators. We investigated the association between SNP loci in FcɛR1β and chronic spontaneous urticaria and to see its relation with serum IgE levels in Kashmiri population. The autologous serum skin test was used as a screening test for chronic autoimmune urticaria. PCR-RFLP was used to detect the genotype of the SNP loci. Serum IgE levels were assessed by ELISA kit. No significant difference was found between the study population and control group in genotype distribution (wild and variant) among FcɛR1β loci (P value=0.06, odds ratio=0.29). The frequency of FcɛR1β (C109T) in autologous serum skin test positive chronic autoimmune urticaria patients with the CT genotype was found to be statistically non-significant when compared with the wild genotype (P=0.35). Carriers of FcɛR1β (T allele) had a more significant risk of developing CAU than those with C allele (P=0.01). In our population serum total IgE levels did not find any statistical significance with regard to ASST positive & ASST negative patients (P=0.26). There is statistically no significant association between FcɛR1β gene polymorphism and CSU in Kashmiri population; however, there is a probability of developing CSU in patients carrying FcɛR1β T allele. Furthermore, serum total IgE levels had no significant association with the development of CAU. Copyright © 2013 SEICAP. Published by Elsevier Espana. All rights reserved.

  19. Leadership's Role in Recruitment and Retention of First Generation, Low-Income Latino Students into STEM Majors

    Science.gov (United States)

    Gonzalez, Eliseo A.

    Fostering resiliency and educational success in students that are faced with adversity is not a simple task. The gap in educational success and achievement among low-income, first generation, traditionally marginalized students continues to be significant. California's educational system needs to stop the hemorrhaging from its educational pipeline, also known as the P-20 pipeline, of all students, especially those groups of students with larger gaps in educational attainment. One potential path towards fixing California's educational pipeline for all students is to form and keep partnerships with programs such as Upward Bound, AVID, and Math Engineering Science Achievement (MESA). In 2010-11, the California Department of Education (CDE) reported that over 51% of students enrolled in California's school system and 51% of all California high school seniors were Latino were Latino. Of the 231,231 Latino high school seniors, 79%, graduated. However, of those that graduated, only 26%, met University of California/California State University (UC/CSU) college entrance requirements. Even though 79% of Latinos graduated, 74% did not qualify to apply to a UC or CSU. If the majority of Latino students continue to fall through holes in the educational pipeline, companies will continue to look abroad to fill STEM jobs that remain unfilled by American workers (California Department of Education [CDE], 2012). Alongside the U.S.'s current economic woes, the lack of college preparedness and knowledge by parents and students has led to a decrease in first generation, low-income Latino students' higher education enrollment (Camacho & Lord, 2011). With strong and positive leadership from family, supplemented by the MESA program, these youths can exert their resiliency, face adversity, and overcome extraordinary barriers. Leaders in education such as teachers, coordinators, advisers, administrators, and parents are in the best position to teach students about resilience (Ginsburg, 2007

  20. Hirshfeld atom refinement

    Directory of Open Access Journals (Sweden)

    Silvia C. Capelli

    2014-09-01

    Full Text Available Hirshfeld atom refinement (HAR is a method which determines structural parameters from single-crystal X-ray diffraction data by using an aspherical atom partitioning of tailor-made ab initio quantum mechanical molecular electron densities without any further approximation. Here the original HAR method is extended by implementing an iterative procedure of successive cycles of electron density calculations, Hirshfeld atom scattering factor calculations and structural least-squares refinements, repeated until convergence. The importance of this iterative procedure is illustrated via the example of crystalline ammonia. The new HAR method is then applied to X-ray diffraction data of the dipeptide Gly–l-Ala measured at 12, 50, 100, 150, 220 and 295 K, using Hartree–Fock and BLYP density functional theory electron densities and three different basis sets. All positions and anisotropic displacement parameters (ADPs are freely refined without constraints or restraints – even those for hydrogen atoms. The results are systematically compared with those from neutron diffraction experiments at the temperatures 12, 50, 150 and 295 K. Although non-hydrogen-atom ADPs differ by up to three combined standard uncertainties (csu's, all other structural parameters agree within less than 2 csu's. Using our best calculations (BLYP/cc-pVTZ, recommended for organic molecules, the accuracy of determining bond lengths involving hydrogen atoms from HAR is better than 0.009 Å for temperatures of 150 K or below; for hydrogen-atom ADPs it is better than 0.006 Å2 as judged from the mean absolute X-ray minus neutron differences. These results are among the best ever obtained. Remarkably, the precision of determining bond lengths and ADPs for the hydrogen atoms from the HAR procedure is comparable with that from the neutron measurements – an outcome which is obtained with a routinely achievable resolution of the X-ray data of 0.65 Å.

  1. 有机农药滴滴涕和毒死蜱生物降解机制的分子模拟研究%Biodegradation Mechanism of DDT and Chlorpyrifos Using Molecular Simulation

    Institute of Scientific and Technical Information of China (English)

    林玉珍; 曾光明; 张娱; 陈明; 蒋敏; 张嘉超; 鲁伦慧; 刘利锋

    2012-01-01

    为探索有机农药滴滴涕和毒死蜱相应降解酶的微观降解机制,用分子对接方法模拟了滴滴涕(DDT)与漆酶(laccase)、毒死蜱(chlorpyrifos)与有机磷水解酶(organophosphorus hydrolase)的相互作用,得到它们复合物结构的理论模型,根据打分函数最低原则筛选出的最佳构象打分函数分别为-103.134和-111.626,二次打分函数分别为-72.858和-80.261.并应用LPC/CSU server研究这些最佳构象的相互作用情况,结果表明,滴滴涕与漆酶之间以疏水作用数量最多,毒死蜱与有机磷水解酶以氢键和疏水作用数量最多.漆酶的Tyr224和有机磷水解酶的Arg254在催化过程中起到了重要作用.%In order to explore the microscopic degradation mechanism of organic pesticides degrading enzymes,we used molecular docking method to investigate the binding modes of DDT to laccase and chlorpyrifos to organophosphorus hydrolase,and obtained the corresponding complex structures.According to the principle of minimum scoring,the results showed that the MolDock scores were-103.134 and-111.626,re-rank scores were-72.858 and-80.261,respectively.And we used LPC/CSU server search the interactions between organic pesticides and their degrading enzymes.Our results showed that hydrophobic interaction was the strongest contacts in DDT-laccase complex,and both hydrogen bonds and hydrophobic interactions were the strongest contacts when chlorpyrifos-organophosphorus hydrolase complex.The amino acid residues Tyr224 in laccase and Arg254 in organophosphorus hydrolase were detected to play significant roles in catalytic processes.

  2. Simulating the 2012 High Plains Drought Using Three Single Column Models (SCM)

    Science.gov (United States)

    Medina, I. D.; Baker, I. T.; Denning, S.; Dazlich, D. A.

    2015-12-01

    The impact of changes in the frequency and severity of drought on fresh water sustainability is a great concern for many regions of the world. One such location is the High Plains, where the local economy is primarily driven by fresh water withdrawals from the Ogallala Aquifer, which accounts for approximately 30% of total irrigation withdrawals from all U.S. aquifers combined. Modeling studies that focus on the feedback mechanisms that control the climate and eco-hydrology during times of drought are limited, and have used conventional General Circulation Models (GCMs) with grid length scales ranging from one hundred to several hundred kilometers. Additionally, these models utilize crude statistical parameterizations of cloud processes for estimating sub-grid fluxes of heat and moisture and have a poor representation of land surface heterogeneity. For this research, we focus on the 2012 High Plains drought and perform numerical simulations using three single column model (SCM) versions of BUGS5 (Colorado State University (CSU) GCM coupled to the Simple Biosphere Model (SiB3)). In the first version of BUGS5, the model is used in its standard bulk setting (single atmospheric column coupled to a single instance of SiB3), secondly, the Super-Parameterized Community Atmospheric Model (SP-CAM), a cloud resolving model (CRM) (CRM consists of 32 atmospheric columns), replaces the single CSU GCM atmospheric parameterization and is coupled to a single instance of SiB3, and for the third version of BUGS5, an instance of SiB3 is coupled to each CRM column of the SP-CAM (32 CRM columns coupled to 32 instances of SiB3). To assess the physical realism of the land-atmosphere feedbacks simulated by all three versions of BUGS5, differences in simulated energy and moisture fluxes are computed between the 2011 and 2012 period and are compared to those calculated using observational data from the AmeriFlux Tower Network for the same period at the ARM Site in Lamont, OK. This research

  3. Identity of Innovative Multifunctional Material Manufacturing Business in Latvia / Inovatīvu Daudzfunkcionālo Materiālu Ražotāju Identitāte Latvijā

    Science.gov (United States)

    Geipele, I.; Staube, T.; Ciemleja, G.; Zeltins, N.; Ekmanis, Yu.

    2015-08-01

    The publication comprises the results from the practical scientific investigation to define the profile and distinctions of the Latvian innovative multifunctional material manufacturing industry. The research is carried out by a holistic approach, including expert interviews, qualitative analysis of the official register data, practical survey, and financial data analysis. The paper seeks to give the detailed data on a technological profile of the mentioned representative companies, if there is a synergy or tough competition in the Latvian market. The current research is topical, because it is unique and does not have analogues in Latvia, and the research is timely due to correspondence with recently stated Research and Innovation Strategies for Smart Specialisation in Latvia. The main findings are associated with recognition of the factors that make impact on commercialisation of the finished goods, obtained financial results and planned directions of development of the respondent companies. Publikācija sniedz veiktā zinātniski praktiskā pētījuma rezultātus, kura ietvaros tika noteikts Latvijas inovatīvu daudzfunkcionālo materiālu ražotāju darbības profils un identitāte. Pētījumā tika izmantota kompleksās analīzes metode, kas ietvēra ekspertu intervijas, uzņēmumu oficiāli reģistrēto datu kvalitatīvo analīzi, zinātniski praktisko aptauju, kā arī pētāmo uzņēmumu finanšu darbības rezultātu analīzi. Zinātniskais darbs sniedz izsmeļošu informāciju par mērķa uzņēmumu tehnoloģisko profilu un pēta, vai Latvijas mērķa ražošanas nozarē ir sinerģijas vai sīvās konkurences pazīmes. Šim zinātniskajam pētījumam ir noteikta aktualitāte saskaņā ar tā unikalitāti Latvijas valsts mērogā un atbilstība Viedās specializācijas stratēģijai. Pētījuma galvenie secinājumi ir saistīti ar uzņēmumu produkcijas komercializācijas ietekmējošo faktoru apzināšanu, sasniegtajiem finansiālajiem rezultātiem un pl

  4. Latvian Waste Management Modelling in View of Environmental Impact Reduction / Latvijas Atkritumu SAIMNIECĪBAS ATTĪSTĪBA un TĀS RADĪTĀS Ietekmes UZ Vidi SAMAZINĀŠANAS MODELĒŠANA

    Science.gov (United States)

    Teibe, I.; Bendere, R.; Arina, D.

    2013-12-01

    In the work, the life-cycle assessment approach is applied to the planning of waste management development in a seaside region (Piejūra) using the Waste Management Planning System (WAMPS) program. In Latvia, the measures to be taken for the climate change mitigation are of utmost importance - especially as related to the WM performance, since a disposal of biodegradable waste presents the primary source of GHG emissions. To reduce the amount of such waste is therefore one of the most significant goals in the State WM plan for 2013-2020, whose adoption is the greatest challenge for municipalities. The authors analyse seven models which involve widely employed biomass processing methods, are based on experimental data and intended for minimising the direct disposal of organic mass at the solid waste landfills. The numerical results obtained evidence that the thermal or biotechnological treatment of organic waste substantially reduces the negative environmental impact of WM practices - by up to 6% as compared with the currently existing. Klimata pārmaiņu samazināšanas pasākumi Latvijā atkritumu saimniecības sektorā ir īpaši svarīgi. jo bioloģiski sadalāmo atkritumu apglabāšana ir viens no būtiskākajiem SEG emisiju avotiem valstī. Pētījumā modelēti virkne sadzīves atkritumu apsaimniekošanas modeļi. kas ietver plašāk izmantotās biomasas pārstrādes metodes un samazina tiešu organiskās masas apglabāšanu cieto sadzīves atkritumu poligonos. Atkritumu apsaimniekošanas modeļu radītās vides ietekmes novērtēšanai izmantota WAMPS (Waste Management Planning System) programma, kas balstīta uz atkritumu apsaimniekošanas procesu dzīves cikla novērtējumu vienā no desmit Latvijas atkritumu apsaimniekošanas reģioniem - Piejūra. Iegūtie kvantitatīvie rezultāti norāda. ka organiskās atkritumu masas pārstrāde un stabilizēšana, izmantojot biotehnoloģijas vai termisko pārstrādi, būtiski samazina atkritumu apsaimniekošanas rad

  5. Infrastructure of Baltic Region Transmission System: Analysis of Technical and Economic Factors of its Development

    Science.gov (United States)

    Obushevs, A.; Oleinikova, I.; Mutule, A.

    2014-08-01

    ērķis ir Baltijas valstu pārvades sistēmas infrastruktūras analīze, pamatojoties uz izstrādāto matemātisko modeli, ņemot vērā katras valsts intereses enerģētikas politikas jomā

  6. Design and Construction of an Affordable Rotating Table for Classroom Demonstrations of Geophysical Fluid Dynamics Principles.

    Science.gov (United States)

    McNoldy, Brian D.; Cheng, Anning; Eitzen, Zachary A.; Moore, Richard W.; Persing, John; Schaefer, Kevin; Schubert, Wayne H.

    2003-12-01

    Rotating tables have been in use for many years because of their ability to demonstrate fluid dynamical phenomena, shedding insight on the sometimes complicated or esoteric mathematics used to describe such processes. A small team of students at the Colorado State University (CSU) Department of Atmospheric Science constructed a rotating table, or “spin tank,” assembly that is simple and affordable, yet instructive.The apparatus is designed to be easy to maintain and operate. The number of moving parts is kept at a minimum, and the electrical components chosen are of high quality. With the aid of a brief instruction manual or tutorial, students and faculty can operate the rotating table and easily perform many demonstrations, with the freedom to vary fluid depth, rotation rate, and acceleration. The entire design and construction process was conducted on a limited budget of &;3,000.A spin tank such as this has practical applications for the qualitative study of fluid dynamics. Fundamental concepts in rotating flow dynamics can be demonstrated to supplement the more rigorous mathematical treatment typically given in oceanography or atmospheric physics graduate-level courses. Topics that have been explored thus far are Ekman pumping, Taylor columns, and barotropic instability, but could be broadened to include subjects such as Rossby waves, baroclinic instability, vortex merger, and thermal convection.

  7. Llama cardiology.

    Science.gov (United States)

    Boon, J A; Knight, A P; Moore, D H

    1994-07-01

    Auscultatory, ECG, and echocardiographic data have been presented for healthy llamas. The literature, however, contains little information on the incidence of congenital and acquired heart disease in the llama. Data compiled from the medical records at CSU-VTH and the VMDB provide an indication of the types of cardiac disease to be found in llamas in North America. A wide variety of congenital cardiac defects are found in llamas, the most prevalent defect of which is VSD. Llamas tend to do well with this defect but are unlikely to be useful pack animals. Acquired heart disease primarily involved inflammatory processes of the pericardium, endocardium, epicardium, and myocardium, and pericardial effusion without documented inflammatory disease. Although not every cardiac murmur necessitates a complete cardiac work-up, every effort should be made to compile accurate medical histories and physical findings related to the cardiac disease in llamas in order to advance our knowledge of these disorders. There also is a need to use available technologies to better define cardiac abnormalities in the llama and accurately report these findings in the literature before cardiology of llamas is fully understood.

  8. Interactions: A Study of Office Reference Statistics

    Directory of Open Access Journals (Sweden)

    Naomi Lederer

    2012-06-01

    Full Text Available Objective – The purpose of this study was to analyze the data from a referencestatistics-gathering mechanism at Colorado State University (CSU Libraries. It aimedprimarily to better understand patron behaviours, particularly in an academic librarywith no reference desk.Methods – The researchers examined data from 2007 to 2010 of College LiaisonLibrarians’ consultations with patrons. Data were analyzed by various criteria,including patron type, contact method, and time spent with the patron. Theinformation was examined in the aggregate, meaning all librarians combined, andthen specifically from the Liberal Arts and Business subject areas.Results – The researchers found that the number of librarian reference consultationsis substantial. Referrals to librarians from CSU’s Morgan Library’s one public servicedesk have declined over time. The researchers also found that graduate students arethe primary patrons and email is the preferred contact method overall.Conclusion – The researchers found that interactions with patrons in librarians’ offices – either in person or virtually – remain substantial even without a traditional reference desk. The data suggest that librarians’ efforts at marketing themselves to departments, colleges, and patrons have been successful. This study will be of value to reference, subject specialist, and public service librarians, and library administrators as they consider ways to quantify their work, not only for administrative purposes, but in order to follow trends and provide services and staffing accordingly.

  9. Paper 5944 Changing Climates @ Colorado State: It's Everybody's Business

    Science.gov (United States)

    Campbell, S.; Calderazzo, J.; Denning, S.; Betsill, M.; Klein, J. A.; Fiege, M.

    2014-12-01

    With the help of faculty from all eight colleges, twenty-seven departments, and numerous other entities on and off the Colorado State University campus, this education and outreach initiative is based on the premises that climate change is everybody's business and that everyone has something to offer in meeting its challenges. Beginning in 2007, CC@CSU has organized some 120 talks to audiences totaling some 6,000, helping inform the student body and community and catalyzing relationships among faculty and researchers across campus. It has offered communication coaching to scientists (and others) who want to translate their expertise for the public. And it has developed a multidisciplinary website (http://changingclimates.colostate.edu) with over 450 annotated entries, all college-level content, primer-level clarity, on topics that include climate science and ecology, economics and emotions, ethics and policy, communication and activism, paleoclimate and human history, and much more. This presentation will address the basic questions of why, who, how, what, for whom, and so what, concluding with some of the key lessons learned about communicating across disciplinary boundaries on this important subject.

  10. Quarks, Leptons as Fermion-Boson Composite Objects and Flavor-Mixings by Substructure Dynamics

    CERN Document Server

    Matsushima, T

    1999-01-01

    A fermion-boson-type composite model for quarks and leptons is proposed. Elementary fields are only one kind of spin-1/2 and spin-0 preon. Both are in the global supersymmetric pair with the common electric charge of e/6 and belong to the fundamental representations of (3,2,2) under the spontaneously unbroken SU(3)_C*SU(2)_L*SU(2)_R gauge symmetry induced necessarily by the concept of ``Cartan connection'' equipped with ``Soldering Mechanism''. Preons are composed into subquarks which are ``intermediate clusters'' towards quarks and leptons. The mechanism of making higher generations is obtained by adding neutral scalar subquark composed of a preon-antipreon pair in the 3-state of SU(2)_{L,R}. This model predicts the CKM matrix elements : |V_{ts}|=2.6*10^{-2}},|V_{td}|=1.4*10^{-3}; the neutral pseudoscalar meson mass differences : {Delta}M_D\\approx10^{-14} GeV, {Delta}M_{B_s}\\approx10^{-11} GeV,{Delta}M_{T_u}\\approx10^{(-10\\sim{-9})} GeV and {theta}_K={\\theta}_D={\\theta}_{B_s}={\\theta}_{T_c}

  11. Lessons Learned from the Deployment and Integration of a Microwave Sounder Based Tropical Cyclone Intensity and Surface Wind Estimation Algorithm into NOAA/NESDIS Satellite Product Operations

    Science.gov (United States)

    Longmore, S. P.; Knaff, J. A.; Schumacher, A.; Dostalek, J.; DeMaria, R.; Chirokova, G.; Demaria, M.; Powell, D. C.; Sigmund, A.; Yu, W.

    2014-12-01

    The Colorado State University (CSU) Cooperative Institute for Research in the Atmosphere (CIRA) has recently deployed a tropical cyclone (TC) intensity and surface wind radii estimation algorithm that utilizes Suomi National Polar-orbiting Partnership (S-NPP) satellite Advanced Technology Microwave Sounder (ATMS) and Advanced Microwave Sounding Unit (AMSU) from the NOAA18, NOAA19 and METOPA polar orbiting satellites for testing, integration and operations for the Product System Development and Implementation (PSDI) projects at NOAA's National Environmental Satellite, Data, and Information Service (NESDIS). This presentation discusses the evolution of the CIRA NPP/AMSU TC algorithms internally at CIRA and its migration and integration into the NOAA Data Exploitation (NDE) development and testing frameworks. The discussion will focus on 1) the development cycle of internal NPP/AMSU TC algorithms components by scientists and software engineers, 2) the exchange of these components into the NPP/AMSU TC software systems using the subversion version control system and other exchange methods, 3) testing, debugging and integration of the NPP/AMSU TC systems both at CIRA/NESDIS and 4) the update cycle of new releases through continuous integration. Lastly, a discussion of the methods that were effective and those that need revision will be detailed for the next iteration of the NPP/AMSU TC system.

  12. Impacts of SiO2 planarization on optical thin film properties and laser damage resistance

    Science.gov (United States)

    Day, T.; Wang, H.; Jankowska, E.; Reagan, B. A.; Rocca, J. J.; Stolz, C. J.; Mirkarimi, P.; Folta, J.; Roehling, J.; Markosyan, A.; Route, R. R.; Fejer, M. M.; Menoni, C. S.

    2016-12-01

    Lawrence Livermore National Laboratory (LLNL) and Colorado State University (CSU) have co-developed a planarization process to smooth nodular defects. This process consists of individually depositing then etching tens of nanometers of SiO2 with a ratio of 2:1, respectively. Previous work shows incorporating the angular dependent ion surface etching and unidirectional deposition reduces substrate defect cross-sectional area by 90%. This work investigates the micro-structural and optical modifications of planarized SiO2 films deposited by ion beam sputtering (IBS). It is shown the planarized SiO2 thin films have 3x increase in absorption and 18% reduction in thin film stress as compared to control (as deposited) SiO2. Planarized SiO2 films exhibit 13% increase in RMS surface roughness with respect to the control and super polished fused silica substrates. Laser-induced damage threshold (LIDT) results indicate the planarization process has no effect on the onset fluence but alters the shape of the probability vs fluence trace.

  13. Advanced CdTe Photovoltaic Technology: September 2007 - March 2009

    Energy Technology Data Exchange (ETDEWEB)

    Barth, K.

    2011-05-01

    During the last eighteen months, Abound Solar (formerly AVA Solar) has enjoyed significant success under the SAI program. During this time, a fully automated manufacturing line has been developed, fabricated and commissioned in Longmont, Colorado. The facility is fully integrated, converting glass and semiconductor materials into complete modules beneath its roof. At capacity, a glass panel will enter the factory every 10 seconds and emerge as a completed module two hours later. This facility is currently undergoing trials in preparation for large volume production of 120 x 60 cm thin film CdTe modules. Preceding the development of the large volume manufacturing capability, Abound Solar demonstrated long duration processing with excellent materials utilization for the manufacture of high efficiency 42 cm square modules. Abound Solar prototype modules have been measured with over 9% aperture area efficiency by NREL. Abound Solar demonstrated the ability to produce modules at industry leading low costs to NREL representatives. Costing models show manufacturing costs below $1/Watt and capital equipment costs below $1.50 per watt of annual manufacturing capacity. Under this SAI program, Abound Solar supported a significant research and development program at Colorado State University. The CSU team continues to make progress on device and materials analysis. Modeling for increased device performance and the effects of processing conditions on properties of CdTe PV were investigated.

  14. TEMPEST-D MM-Wave Radiometer

    Science.gov (United States)

    Padmanabhan, S.; Gaier, T.; Reising, S. C.; Lim, B.; Stachnik, R. A.; Jarnot, R.; Berg, W. K.; Kummerow, C. D.; Chandrasekar, V.

    2016-12-01

    The TEMPEST-D radiometer is a five-frequency millimeter-wave radiometer at 89, 165, 176, 180, and 182 GHz. The direct-detection architecture of the radiometer reduces its power consumption and eliminates the need for a local oscillator, reducing complexity. The Instrument includes a blackbody calibrator and a scanning reflector, which enable precision calibration and cross-track scanning. The MMIC-based millimeter-wave radiometers take advantage of the technology developed under extensive investment by the NASA Earth Science Technology Office (ESTO). The five-frequency millimeter-wave radiometer is built by Jet Propulsion Laboratory (JPL), which has produced a number of state-of-the-art spaceborne microwave radiometers, such as the Microwave Limb Sounder (MLS), Advanced Microwave Radiometer (AMR) for Jason-2/OSTM, Jason-3, and the Juno Microwave Radiometer (MWR). The TEMPEST-D Instrument design is based on a 165 to 182 GHz radiometer design inherited from RACE and an 89 GHz receiver developed under the ESTO ACT-08 and IIP-10 programs at Colorado State University (CSU) and JPL. The TEMPEST reflector scan and calibration methodology is adapted from the Advanced Technology Microwave Sounder (ATMS) and has been validated on the Global Hawk unmanned aerial vehicle (UAV) using the High Altitude MMIC Sounding radiometer (HAMSR) instrument. This presentation will focus on the design, development and performance of the TEMPEST-D radiometer instrument. The flow-down of the TEMPEST-D mission objectives to instrument level requirements will also be discussed.

  15. Modifying the DPClus algorithm for identifying protein complexes based on new topological structures

    Directory of Open Access Journals (Sweden)

    Wang Jian-xin

    2008-09-01

    Full Text Available Abstract Background Identification of protein complexes is crucial for understanding principles of cellular organization and functions. As the size of protein-protein interaction set increases, a general trend is to represent the interactions as a network and to develop effective algorithms to detect significant complexes in such networks. Results Based on the study of known complexes in protein networks, this paper proposes a new topological structure for protein complexes, which is a combination of subgraph diameter (or average vertex distance and subgraph density. Following the approach of that of the previously proposed clustering algorithm DPClus which expands clusters starting from seeded vertices, we present a clustering algorithm IPCA based on the new topological structure for identifying complexes in large protein interaction networks. The algorithm IPCA is applied to the protein interaction network of Sacchromyces cerevisiae and identifies many well known complexes. Experimental results show that the algorithm IPCA recalls more known complexes than previously proposed clustering algorithms, including DPClus, CFinder, LCMA, MCODE, RNSC and STM. Conclusion The proposed algorithm based on the new topological structure makes it possible to identify dense subgraphs in protein interaction networks, many of which correspond to known protein complexes. The algorithm is robust to the known high rate of false positives and false negatives in data from high-throughout interaction techniques. The program is available at http://netlab.csu.edu.cn/bioinformatics/limin/IPCA.

  16. Modelling the internal boundary layer over the lower fraser valley, British Columbia

    Energy Technology Data Exchange (ETDEWEB)

    Batchvarova, E. [National Inst. of Meteorology and Hydrology, Sofia (Bulgaria); Steyn, D. [Univ. of British Columbia, Dept. of Geography, Vancouver (Canada); Cai, X. [Univ. of Birmingham, School of Geography, Edgbaston (United Kingdom); Gryning, S.E. [Risoe National Lab., Roskilde (Denmark); Baldi, M. [Inst. for Atmospheric Physics, IFA-CNR, Rome (Italy)

    1997-10-01

    In this study we use the very extensive data-set on temporal and spatial structure of the internal boundary layer on the Lower Faser Valley, Canada, collected during the so-called Pacific `93 field campaign, to study the ability of the simple applied model by Gryning and Batchvarova (1996) and the CSU-RAMS meso-scale model summarised in Pielke et al. (1992) to describe the development and variability of the internal boundary layer depth during the course of a day. Given the complexity of topography, coastline and land-use in the Lower Fraser Valley region, both models perform remarkably well. The simple applied model performs extremely well, given its simplicity. It is clear that correct specification of spatially resolved surface sensible heat flux and wind field are crucial to the success of this model which can be operated at very fine spatial resolution. The 3D model performs extremely well, though it too must capture the local wind field correctly for complete success. Its limited horizontal resolution results in strongly smoothed internal boundary layer height fields. (LN)

  17. Parameterization of convective clouds mesoscale convective systems, and convective-generated cirrus. Final report, September 15, 1990--October 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Cotton, W.R.

    1993-11-05

    The overall goal of this research is to develop a scheme to parameterize diabatic heating, moisture/water substance, and momentum transports, and precipitation from mesoscale convective systems (MCSs) for use in general circulation models (GCMs). Our approach is to perform explicit cloud-resolving simulations of MCSs in the spirit of the GEWEX Cloud Systems Study (GCSS), by using the Regional Atmospheric Modeling System (RAMS) developed at Colorado State University (CSU). We then perform statistical analyses (conditional sampling, ensemble-averages, trajectory analyses) of simulated MCSs to assist in fabricating a parameterization scheme, calibrating coefficients, and provide independent tests of the efficacy of the parameterization scheme. A cloud-resolving simulation of ordinary cumulonimbi forced by sea breeze fronts has been completed. Analysis of this case and comparison with parameterized convection simulations has resulted in a number of refinements in the scheme. Three three-dimensional, cloud-resolving simulations of MCSs have been completed. Statistical analyses of model-output data are being performed to assist in developing a parameterization scheme of MCSs in general circulation models.

  18. A Goddard Multi-Scale Modeling System with Unified Physics

    Science.gov (United States)

    Tao, Wei-Kuo

    2010-01-01

    A multi-scale modeling system with unified physics has been developed at NASA Goddard Space Flight Center (GSFC). The system consists of an MMF, the coupled NASA Goddard finite-volume GCM (fvGCM) and Goddard Cumulus Ensemble model (GCE, a CRM); the state-of-the-art Weather Research and Forecasting model (WRF) and the stand alone GCE. These models can share the same microphysical schemes, radiation (including explicitly calculated cloud optical properties), and surface models that have been developed, improved and tested for different environments. In this talk, I will present: (1) A brief review on GCE model and its applications on the impact of the aerosol on deep precipitation processes, (2) The Goddard MMF and the major difference between two existing MMFs (CSU MMF and Goddard MMF), and preliminary results (the comparison with traditional GCMs), and (3) A discussion on the Goddard WRF version (its developments and applications). We are also performing the inline tracer calculation to comprehend the physical processes (i.e., boundary layer and each quadrant in the boundary layer) related to the development and structure of hurricanes and mesoscale convective systems. In addition, high - resolution (spatial. 2km, and temporal, I minute) visualization showing the model results will be presented.

  19. Successful Omalizumab treatment in HIV positive patient with chronic spontaneous urticaria: a case report.

    Science.gov (United States)

    Iemoli, E; Niero, F; Borgonovo, L; Cossu, M V; Piconi, S

    2017-03-01

    We described a case of a 56 year old homosexual HIV positive man who presented a history of CSU since one year (2012). All the allergologic, immunologic and microbiologic tests to evaluate the pathogenesis of wheals resulted negative. Therefore in June 2015 we decided to start therapy with Omalizumab while the patient kept on effective antiretroviral therapy with 310 cells/mm3 TCD4 counts and undetectable HIV viremia. After two monthly subcutaneuous injection of 150 mg of Omalizumab the patient had no more urticarial symptoms. UAS7 (Urticaria Activity Score over 7 days) and Cu-Q2oL (chronic urticarial quality of life questionnaire) dropped respectively to 14 from 42 and to 0 from 40 with increase of TCD4 counts while viral load remained undetectable. In November 2015, i.e. 4 months after the end of Omalizumab therapy, the patient was still asymptomatic with persistent effective immune-virological response to antiretroviral therapy. This case report confirms the excellent tolerability and efficacy of anti-IgE therapy in the treatment of spontaneous chronic urticarial even in an immunodepressed patient for HIV infection. Omalizumab therapy shows a remarkable clinical success and had no effect on peripheral TCD4 counts and HIV viral load.

  20. Accurate Characterization of Winter Precipitation Using Multi-Angle Snowflake Camera, Visual Hull, Advanced Scattering Methods and Polarimetric Radar

    Directory of Open Access Journals (Sweden)

    Branislav M. Notaroš

    2016-06-01

    Full Text Available This article proposes and presents a novel approach to the characterization of winter precipitation and modeling of radar observables through a synergistic use of advanced optical disdrometers for microphysical and geometrical measurements of ice and snow particles (in particular, a multi-angle snowflake camera—MASC, image processing methodology, advanced method-of-moments scattering computations, and state-of-the-art polarimetric radars. The article also describes the newly built and established MASCRAD (MASC + Radar in-situ measurement site, under the umbrella of CSU-CHILL Radar, as well as the MASCRAD project and 2014/2015 winter campaign. We apply a visual hull method to reconstruct 3D shapes of ice particles based on high-resolution MASC images, and perform “particle-by-particle” scattering computations to obtain polarimetric radar observables. The article also presents and discusses selected illustrative observation data, results, and analyses for three cases with widely-differing meteorological settings that involve contrasting hydrometeor forms. Illustrative results of scattering calculations based on MASC images captured during these events, in comparison with radar data, as well as selected comparative studies of snow habits from MASC, 2D video-disdrometer, and CHILL radar data, are presented, along with the analysis of microphysical characteristics of particles. In the longer term, this work has potential to significantly improve the radar-based quantitative winter-precipitation estimation.

  1. Feline intestinal sclerosing mast cell tumour: 50 cases (1997-2008).

    Science.gov (United States)

    Halsey, C H C; Powers, B E; Kamstock, D A

    2010-03-01

    This case series presents a unique and unreported variant of feline intestinal mast cell tumour recognized at the CSU Veterinary Diagnostic Laboratory. Fifty cases of feline intestinal mast cell tumours described as having a significant stromal component were reviewed. Neoplastic cells formed a trabecular pattern admixed with moderate to abundant dense stromal collagen (sclerosis). Neoplastic cells had poorly discernible intracytoplasmic granules which demonstrated metachromasia with special histochemical stains consistent with mast cell granules. Additionally, a subset of cases stained for mast cell-specific tryptase and c-kit demonstrated positive immunoreactivity. Eosinophilic infiltrates were moderate to marked in almost all cases. Lymph node and hepatic metastases were present in 66% of the cases. Treatment and clinical outcome was available in 25/50 cases. Twenty-three of these patients died or were euthanized within 2 months of initial diagnosis. This is the first case series to characterize a sclerosing variant of intestinal mast cell tumour in the cat which appears to have a high propensity for metastasis and a guarded prognosis.

  2. Final report ASTC Program

    Energy Technology Data Exchange (ETDEWEB)

    Smithson, T.

    1996-03-15

    The specific goals of the ASTC program were: to pilot and administer a year round program to engage and support ethnic minority and women students to enter the pre-college teaching profession; and to develop the ASTC program across California on all twenty CSU campuses. The initial goal of piloting a year round program to engage and support ethnic or underrepresented science students to enter the teaching profession was put in place at CSUS in the Fall of 1993, with the recruitment of students to enter the program in the Spring of 1993. Three students were selected to enter the program, one male Latino, one female Latina and one Caucasian female. The areas of study of these students was respectively biology, physics and geology. All of the students were within two years or less of completing their degree requirements. During the first semester of the program the authors worked on the portion of the model dealing with student participation in the schools with a mentor teacher. The idea being the students would spend a minimum of six hours a week in the classroom of the mentor teacher working with them and their students. In addition the students were assigned to a faculty mentor within their discipline, a person whom they could go to for help and support in their academic efforts. The report discusses what was learned.

  3. Manchester Ice Nucleus Counter (MINC measurements from the 2007 International workshop on Comparing Ice nucleation Measuring Systems (ICIS-2007

    Directory of Open Access Journals (Sweden)

    H. M. Jones

    2011-01-01

    Full Text Available An ice nucleus counter was developed and constructed to enable investigation of potential ice nucleating materials. The Manchester Ice Nucleus Chamber (MINC is a concentric-cylinder continuous flow diffusion chamber (CFDC. A full explanation of the MINC instrument is given here, along with first results and a comparison to an established instrument of similar design (Colorado State University CFDC during sampling of common ice nucleating aerosols at the 2007 International workshop on Comparing Ice nucleation Measuring Systems (ICIS-2007. MINC and CSU-CFDC detected the onset of ice nucleation under similar conditions of temperature and supersaturation for several different types of ice nuclei. Comparisons of the ratio of ice nuclei to total aerosol concentrations as a function of supersaturation with respect to water (SSw showed agreement within one order of magnitude. Possible reasons for differences between the two instruments relating to differences in their design are discussed, along with suggestions to future improvements to the current design.

  4. The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells.

    Science.gov (United States)

    Gaddy, Jennifer A; Tomaras, Andrew P; Actis, Luis A

    2009-08-01

    The ability of Acinetobacter baumannii to adhere to and persist on surfaces as biofilms could be central to its pathogenicity. The production of pili and a biofilm-associated protein and the expression of antibiotic resistance are needed for robust biofilm formation on abiotic and biotic surfaces. This multistep process also depends on the expression of transcriptional regulatory functions, some of which could sense nutrients available to cells. This report extends previous observations by showing that although outer membrane protein A (OmpA) of A. baumannii 19606 plays a partial role in the development of robust biofilms on plastic, it is essential for bacterial attachment to Candida albicans filaments and A549 human alveolar epithelial cells. In contrast to abiotic surfaces, the interaction with biotic surfaces is independent of the CsuA/BABCDE-mediated pili. The interaction of A. baumannii 19606 with fungal and epithelial cells also results in their apoptotic death, a response that depends on the direct contact of bacteria with these two types of eukaryotic cells. Furthermore, the bacterial adhesion phenotype correlates with the ability of bacteria to invade A549 epithelial cells. Interestingly, the killing activity of cell-free culture supernatants proved to be protease and temperature sensitive, suggesting that its cytotoxic activity is due to secreted proteins, some of which are different from OmpA.

  5. Development of Management Metrics for Research and Technology

    Science.gov (United States)

    Sheskin, Theodore J.

    2003-01-01

    Professor Ted Sheskin from CSU will be tasked to research and investigate metrics that can be used to determine the technical progress for advanced development and research tasks. These metrics will be implemented in a software environment that hosts engineering design, analysis and management tools to be used to support power system and component research work at GRC. Professor Sheskin is an Industrial Engineer and has been involved in issues related to management of engineering tasks and will use his knowledge from this area to allow extrapolation into the research and technology management area. Over the course of the summer, Professor Sheskin will develop a bibliography of management papers covering current management methods that may be applicable to research management. At the completion of the summer work we expect to have him recommend a metric system to be reviewed prior to implementation in the software environment. This task has been discussed with Professor Sheskin and some review material has already been given to him.

  6. Delivering Online Examinations: A Case Study

    Directory of Open Access Journals (Sweden)

    John MESSING

    2004-07-01

    Full Text Available Delivering Online Examinations: A Case Study Jason HOWARTH John MESSING Irfan ALTAS Charles Sturt University Wagga Wagga-AUSTRALIA ABSTRACT This paper represents a brief case study of delivering online examinations to a worldwide audience. These examinations are delivered in partnership with a commercial online testing company as part of the Industry Master’s degree at Charles Sturt University (CSU. The Industry Master’s degree is an academic program for students currently employed in the IT industry. Using Internet Based Testing (IBT, these students are examined in test centres throughout the world. This offers many benefits. For example, students have the freedom of sitting exams at any time during a designated interval. Computer-based testing also provides instructors with valuable feedback through test statistics and student comments. In this paper, we document CSU’s use of the IBT system, including how tests are built and delivered, and how both human and statistical feedback is used to evaluate and enhance the testing process.

  7. Three dimensional quantum geometry and deformed symmetry

    Science.gov (United States)

    Joung, E.; Mourad, J.; Noui, K.

    2009-05-01

    We study a three dimensional noncommutative space emerging in the context of three dimensional Euclidean quantum gravity. Our starting point is the assumption that the isometry group is deformed to the Drinfeld double D(SU(2)). We generalize to the deformed case the construction of E3 as the quotient of its isometry group ISU(2) by SU(2). We show that the algebra of functions on E3 becomes the noncommutative algebra of SU(2) distributions, C(SU(2))∗, endowed with the convolution product. This construction gives the action of ISU(2) on the algebra and allows the determination of plane waves and coordinate functions. In particular, we show the following: (i) plane waves have bounded momenta; (ii) to a given momentum are associated several SU(2) elements leading to an effective description of ϕ ɛC(SU(2))∗ in terms of several physical scalar fields on E3; (iii) their product leads to a deformed addition rule of momenta consistent with the bound on the spectrum. We generalize to the noncommutative setting the "local" action for a scalar field. Finally, we obtain, using harmonic analysis, another useful description of the algebra as the direct sum of the algebra of matrices. The algebra of matrices inherits the action of ISU(2): rotations leave the order of the matrices invariant, whereas translations change the order in a way we explicitly determine.

  8. Enhanced color gauge invariance and a new di-photon state at the LHC

    CERN Document Server

    Alexander, Stephon

    2016-01-01

    We propose to interpret the possible resonance seen in di-photons at the LHC at 750 Gev as a bound state of a new pair of heavy gluons associated with an enhanced color gauge invariance. These have a conservation law which enforces their production and decay in pairs and hence requires that the leading coupling to quarks is quadratically through a dimension 5 operator. One way to realize these hypotheses is if the SU(3) color gauge invariance is enhanced to SL(3, C), while at the same time promoting the internal metric, which picks out what is a unitary transformation, to a dynamical degree of freedom. This theory was first proposed by Cahill[3], Dell[4], Kim and Zee[5], and Julia and Luciani[6]. The dynamical internal metric spontaneously breaks SL(3,C) to SU(3) giving a mass to the vector bosons associated with the generators in SL(3,C)/SU(3). The coupling to the internal metric also ensures that the energy is bounded from below. The new state is produced by gluon fusion and decays to a pair of photons via ...

  9. A New Campus Built on Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Harding, Ari [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mercado, Andrea [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Regnier, Cindy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-08-01

    The University of California (UC), Merced partnered with the U.S. Department of Energy (DOE) to develop and implement solutions to reduce energy consumption by as part of DOE’s Commercial Buildings Partnerships (CBP) Program. Lawrence Berkeley National Laboratory (LBNL) provided technical expertise in support of this DOE program. This case study reports on the process and outcome of this project including the achieved savings from design improvements for the campus. The intent of the project was to retrofit the Science & Engineering (S&E) building and the central plant at UC Merced to achieve up to 30% energy reduction. The anticipated savings from these retrofits represented about 17% of whole-campus energy use. If achieved, the savings contribution from the CBP project would have brought overall campus performance to 56% of the 1999 UC/CSU benchmark performance for their portfolio of buildings. However, the final design that moved forward as part of the CBP program only included the retrofit measures for the S&E building.

  10. [Angioedema and urticaria].

    Science.gov (United States)

    Boccon-Gibod, I; Bouillet, L

    2014-11-01

    Angiœdema (AE) is the clinical expression of urticaria (U) which occurs when urticaria is located within the subcutis. It is a syndrome characterized by a sudden and limited subcutaneous and/or submucous swelling. The updated classification of urticaria distinguishes acute and chronic urticaria. Chronic urticaria is spontaneous (CSU) or inducible (CIU). Angioedema in chronic urticaria is rarely allergic, but most of the time caused by a non-specific histamine release from activated mast-cell (non IgE mediated reaction). Angioedemas are recurrent, concomitant or not with wheals. They appear skin-coloured, sometimes slightly rosy, non-inflammatory, and more painful than itchy. They are transient, ephemeral, migrant, last most of the time a few hours (urticaria" and wheals "superficial urticaria". When AE or wheals last more than 6 weeks (with or without free intermission), it is called chronic urticaria. Angioedema can be elicited or worsened by physical factors (cold urticaria, exercise, heat, solar, vibratory, aquagenic, delayed pressure urticaria…) and /or drugs (as aspirin, nonsteroid anti-inflammatory drugs, morphine, antibiotics…). The treatment of histaminergic angioedemas of chronic urticaria is based on modern second generation antihistamines (anti H1). In allergic acute urticaria only, additional treatment for anaphylaxis can be used if needed (grade 2 to 4). In chronic urticaria, steroids should be avoided : they can make symptoms worse and long-lasting because of corticosteroid dependence.

  11. Clinical epidemiological characteristics of chronic urticaria: report of 535 cases%535例慢性荨麻疹临床流行病学特征分析

    Institute of Scientific and Technical Information of China (English)

    罗婕; 郝飞; 宋志强; 钟华; 尹锐; 黄秀英; 李垚莹; 程良金; 向明明; 王莉

    2011-01-01

    目的 了解慢性荨麻疹(chronic urticaria,CU)临床流行病学特征.方法 以2010年1月1日至9月30日,对临床确诊为CU的535例患者进行问卷调查.调查数据录入EpiData数据库,运用SPSS 13.0统计软件进行分析.结果 共收到有效问卷535例,其中男性204例,女性331例,年龄(34.4±14.0)岁,初发年龄(30.6±14.8)岁,以20~40岁多见.诱发因素中物理因素94例(17.6%),药物23例(4.3%),食物29例(5.4%),精神因素39例(7.3%),工作压力9例(1.7%),蚊虫叮咬24例(4.5%),其他54例(10.0%),无明显诱因263例(49.2%).临床分型中最常见是慢性自发性荨麻疹(chronic spontaneous urticaria,CSU)294例(55.0%),其次皮肤划痕症120例(22.4%),未发现延迟压力性、震动性和运动诱发性荨麻疹.CU伴血管性水肿105例(19.6%),其中,女性70例(21.1%),CSU 76例(25.9%).自体血清皮肤试验(ASST)总阳性率为49.6%.结论 CU发病以青壮年为主,临床表现形式多样,伴发血管性水肿并非少见.关注CU的临床流行病学特征,有利于指导临床治疗.%Objective To investigate clinical epidemiological charateristics of chronic urticaria (CU). Methods A survey was conducted to clinically diagnosed CU patients in our hospitals from January to September 2010. All these subjects received physical examination by dermatologists and were required to fulfill the self-report questionnaires. EpiData and SPSS 13.0 were utilized for statistical analysis. Results Totally, there were 535 valid questionnaires returned in this survey. Of them, 204 were male and 331 were female with a mean age of 34.4 ± 14.0. The average age of these subjects at first onset was 30.6 ± 14.8. The prevalence of CU peaked in patients aging from 20 to 40 years. The self-reported eliciting factors of urticaria were as follows: physical stimuli 94 ( approximately 17. 6% ), drugs 23 (4. 3% ) , foods 29 (5. 4% ) , mental factor 39 (7. 3% ), working pressure 9 (1.7%), mosquito 24 (4. 5

  12. The use of meteorological station in Science Park during May floods

    Science.gov (United States)

    Marković-Topalović, Tatjana; Božić, Mirjana; Stojićević, Goran

    2015-04-01

    A lot of educators and education process researchers have noticed and pointed out the need of broader learning space than a mere classroom, in learning physics and natural sciences. Many cognitive installations and didactic patterns for an extended school space have been proposed and implemented in schools [1, 2] and outdoor science parks [3]. From their side, school designers have argued that the learning environments can be more educationally and optimally useful if the architecture of the built, natural and cultural environment would be used as a teaching tool [4]. Through the merge of these two tendencies the concept of a school as a three-dimensional textbook was created [2]. The growing team of educators and researchers in Serbia [2] has been promoting this idea among students, teachers, and cultural and educational authorities, ranging from individual schools and municipality to state level, with emphasis on the school buildings investors and public. The net of schools and educational institutions has been implementing this concept [5]. Their activities have attracted the attention of newspapers and e-media [5]. The Science Park in Šabac, developed in the town in the vicinity of Belgrade, was completed in 2010. The Science Park is a part of the Center for professional advancement of educators (CSU) [6] that is surrounded by the eight-year Primary school, kindergarten, water tower and the church. Twenty-six interactive installations are connected to teaching units from all science subjects. For example: The periodic system of elements was placed on the building facade, the structure of graphene, sodium-chloride crystal structure, planetary model of atom (Chemistry) Pythagorean theorem, pyramid related to Tales doubt, golden ratio (Mathematics); model of DNA (Biology); globe-DING, educative fountain, brachistochrone, Newton's pendulum (Physics), the Greenwich meridian replica, sundial and meteorological station (Earth's science). During May 2014, when big

  13. Spatial variability of soil and vegetation characteristics in an urban park in Tel-Aviv

    Science.gov (United States)

    Sarah, Pariente; Zhevelev, Helena M.; Oz, Atar

    2010-05-01

    Mosaic-like spatial patterns, consisting of divers soil microenvironments, characterize the landscapes of many urban parks. These microenvironments may differ in their pedological, hydrological and floral characteristics, and they play important roles in urban ecogeomorphic system functioning. In and around a park covering 50 ha in Tel Aviv, Israel, soil properties and herbaceous vegetation were measured in eight types of microenvironments. Six microenvironments were within the park: area under Ceratonia siliqua (Cs-U), area under Ficus sycomorus (Fi-U), a rest area under F. sycomorus (Re-U), an open area with bare soil (Oa-S), an open area with biological crusts (Oa-C), and an open area with herbaceous vegetation (Oa-V). Outside the park were two control microenvironments, located, respectively, on a flat area (Co-P) and an inclined open area (Co-S). The soil was sampled from two depths (0-2 and 5-10 cm), during the peak of the growing season (March). For each soil sample, moisture content, organic matter content, CaCO3 content, texture, pH, electrical conductivity, and soluble ions contents were determined in 1:1 water extraction. In addition, prior to the soil sampling, vegetation cover, number of species, and species diversity of herbaceous vegetation were measured. The barbecue fires and visitors in each of the microenvironments were counted. Whereas the soil organic matter and vegetation in Fi-U differed from those in the control(Co-P, Co-S), those in Oa-V were similar to those in the control. Fi-U was characterized by higher values of soil moisture, organic matter, penetration depth, and vegetation cover than Cs-U. Open microenvironments within the park (Oa-S, Oa-C, Oa-V) showed lower values of soil penetration than the control microenvironments. In Oa-V unique types of plants such as Capsella bursa-pastoris and Anagallis arvensis, which did not appear in the control microenvironments, were found. This was true also for Fi-U, in which species like Oxalis pes

  14. IMPROVEMENT TO PIPELINE COMPRESSOR ENGINE RELIABILITY THROUGH RETROFIT MICRO-PILOT IGNITION SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Scott Chase; Daniel Olsen; Ted Bestor

    2005-05-01

    This report documents a 3-year research program conducted by the Engines & Energy Conversion Laboratory (EECL) at Colorado State University (CSU) to develop micropilot ignition systems for existing pipeline compressor engines. Research activities for the overall program were conducted with the understanding that the efforts are to result in a commercial product to capture and disseminate the efficiency and environmental benefits of this new technology. An extensive state-of-art review was conducted to leverage the existing body of knowledge of micropilot ignition with respect to retrofit applications. Additionally, commercially-available fuel injection products were identified and applied to the program where appropriate. This approach will minimize the overall time-to-market requirements, while meeting performance and cost criteria. The objective for Phase I was to demonstrate the feasibility of micropilot ignition for large bore, slow speed engines operating at low compression ratios under laboratory conditions at the EECL. The primary elements of Micropilot Phase I were to develop a single-cylinder test chamber to study the injection of pilot fuel into a combustion cylinder and to develop, install and test a multi-cylinder micropilot ignition system for a 4-cylinder, natural gas test engine. In all, there were twelve (12) tasks defined and executed to support these two (2) primarily elements in a stepwise fashion. Task-specific approaches and results are documented in this report. The four-cylinder prototype data was encouraging for the micro-pilot ignition technology when compared to spark ignition. The objective for Phase II was to further develop and optimize the micropilot ignition system at the EECL for large bore, slow speed engines operating at low compression ratios. The primary elements of Micropilot Phase II were to evaluate the results for the 4-cylinder system prototype developed for Phase I, then optimize this system and prepare the technology for

  15. Heritabilities and genetic correlations of pulmonary arterial pressure and performance traits in Angus cattle at high altitude.

    Science.gov (United States)

    Crawford, N F; Thomas, M G; Holt, T N; Speidel, S E; Enns, R M

    2016-11-01

    Pulmonary arterial pressure (PAP) is an indicator trait for pulmonary hypertension and for the risk of developing high-altitude disease (HAD) in cattle. Pulmonary arterial pressures provide a tool for selection of breeding cattle for tolerance to high altitude in mountainous regions of the United States. The objective of this study was to evaluate relationships between growth performance traits and yearling PAP (42.4 ± 9.9 mmHg; = 5,776; elevation 2,150 m) using data from 1993 to 2014 in the John E. Rouse Colorado State University Beef Improvement Center (CSU-BIC) Angus herd. The breeding program used sires ( = 299) from both low- and high-elevation environments. We hypothesized that little to no genetic relationship exists between PAP and birth weight (BWT; direct and maternal), weaning weight (WW; direct and maternal), yearling weight (YW; direct and maternal), and postweaning gain (PWG). Historic selection of natural service sires from within the herd required a PAP of ≤ 42 mmHg. Outside AI sires ( = 156) used in this breeding program were not PAP tested and therefore were used with little knowledge of these sires' high-altitude adaptability. Performance traits (± SD) routinely recorded included BWT (36.2 ± 5.1 kg; = 8,695), WW (213.5 ± 31.8 kg; = 8,010), YW (345.6 ± 83.8 kg; = 5,580), and PWG (122.0 ± 63.7 kg; = 5,449), where PWG represented the total weight gained from weaning to yearling age. Four-trait analyses using REML were conducted with an animal model. The heritability estimates (± SE) for PAP (0.26 ± 0.03), BWT direct (0.42 ± 0.04) and maternal (0.14 ± 0.02), WW direct (0.29 ± 0.04) and maternal (0.19 ± 0.03), YW direct (0.45 ± 0.04) and maternal (0.23 ± 0.03), and PWG (0.14 ± 0.02) were in the range of those reported in previous literature. Estimates of genetic correlations (± SE) revealed weak relationships between PAP and direct and maternal BWT, direct and maternal WW, direct and maternal YW, and PWG of 0.15 ± 0.09, 0.14 ± 0

  16. Numerical modeling study into the climatic impact of deforestation associated with the fall of Mayan Empire

    Science.gov (United States)

    Kongoli, C.; Nair, U. S.; Welch, R. M.; Sever, T. L.; Irwin, D.; Pielke, R. A.

    2002-05-01

    The collapse the Mayan Empire, which flourished from 250 to 900 AD in the Southern Mexico and Central American regions, is one of the greatest demographic disasters in the human history. Early studies of Mayan civilization found cessation in dating and inscription of monuments in the ninth century. Later studies suggest a two-thirds decline in Mayan population numbering millions between 830 and 900 AD. The reason for this population decline and the subsequent collapse of Mayan Empire in ninth century is not known. The mass exodus of population has been ruled out since the population in the surrounding regions remained stable during this time period. Other suggested reasons for this population decline include conflict, disease, warfare, climate change. However, studies of historical pollen data indicate increased rates of deforestation starting in the fifth century with most of the trees in the region being cut down by the ninth century. Lake core sediments document a major drought around 800 AD that was one of the most intense drought in an 8000 year history. A recent study on climatic reconstruction from pollen records also indicate that climate became drier following the collapse of the Mayan Empire, and suggest that this may be due to the cutting down of trees. In the present study, the effect of forest clearing on the regional climate in the Mayan region is examined using the Colorado State University Regional Atmospheric Modeling System (CSU RAMS). The RAMS is being used to simulate the rainfall over the Mayan region for conditions where the surface is assumed to be completely forested and deforested. Simulations are being done for two months, both in the wet and dry season. Comparison of RAMS simulated rainfall between the completely forested and deforested scenarios are expected to provide bounds on regional climate change brought about by deforestation. Further details will be presented at the conference.

  17. Design, Construction and Testing of Annular Diffusers for High Speed Civil Transportation Combustor Applications

    Science.gov (United States)

    Okhio, Cyril B.

    1996-01-01

    A theoretical and an experimental design study of subsonic flow through curved-wall annular diffusers has been initiated under this award in order to establish the most pertinent design parameters and hence performance characteristics for such devices, an the implications of their application in the design of engine components in the aerospace industries. The diffusers under this study are expected to contain appreciable regions of stall and the effects of swirl on their performance are being studied. The experimental work involves the application of Computer Aided Design software tool to the development of a suitable annular diffuse geometry and the subsequent downloading of such data to a CNC machine at Central State University (CSU). Two experimental run segments have been completed so far during FY-95 involving flow visualization and diffuser performance evaluation based on Kinetic Energy Dissipation. The method of calculation of the performance of diffusers based on pressure recovery coefficient has been shown to have some shortcomings and so the kinetic energy dissipation approach has been introduced in the run segment two with some success. The application of the discretized, full Navier Stokes and Continuity equations to the numerical study of the problem described above for the time-mean flow is expected to follow. Various models of turbulence are being evaluated for adoption throughout the study and comparisons would be made with experimental data where they exist. Assessment of diffuser performance based on the dissipated mechanical energy would also be made. The result of the investigations are expected to indicate that more cost effective component design of such devices as diffusers which normally contain complex flows can still be achieved.

  18. Successes, Challenges and Lessons Learned for Recruiting, Engaging and Preparing a Diverse Student Population for 21st Century Careers in Ocean Sciences.

    Science.gov (United States)

    Clarkston, B. E.; Garza, C.

    2015-12-01

    Diversity within the Ocean Sciences workforce is still underperforming relative to other scientific disciplines, a problem that will be only be solved by recruiting, engaging and retaining a more diverse student population. The Monterey Bay Regional Ocean Science Research Experiences for Undergraduates program is housed at California State University, Monterey Bay (CSUMB), an HSI with strong connections to multiple regional community colleges and other Predominantly Undergraduate Institutions (PUIs) in the CSU system. From this unique position, 11 sophomore and junior-level undergraduate students are recruited per year from academic institutions where research opportunities in STEM are limited and from groups historically underrepresented in the Ocean Sciences, including women, underrepresented minorities, persons with disabilities, and veterans. During the program, students engage in a 10-week original research project guided by a faculty research mentor in one of four themes: Oceanography, Marine Biology and Ecology, Ocean Engineering, and Marine Geology. In addition to research, students engage in rigorous weekly professional development workshops in which they practice critical thinking, ethical decision-making, peer review, writing and oral communication skills. These workshops include tangible products such as an NSF-style proposal paper, Statement of Purpose and CV modelled for the SACNAS Travel Award Application, research abstract, scientific report and oral presentation. To help retain students in Ocean Sciences, students build community during the REU by living together in the CSUMB dormitories; post-REU, students stay connected through an online facebook group, LinkedIn page and group webinars. To date, the REU has supported 22 students in two cohorts (2014, 2015) and here we present successes, challenges and lessons learned for a program designed to prepare students for 21st century Ocean Science careers.

  19. The success of acinetobacter species; genetic, metabolic and virulence attributes.

    Directory of Open Access Journals (Sweden)

    Anton Y Peleg

    Full Text Available An understanding of why certain Acinetobacter species are more successful in causing nosocomial infections, transmission and epidemic spread in healthcare institutions compared with other species is lacking. We used genomic, phenotypic and virulence studies to identify differences between Acinetobacter species. Fourteen strains representing nine species were examined. Genomic analysis of six strains showed that the A. baumannii core genome contains many genes important for diverse metabolism and survival in the host. Most of the A. baumannii core genes were also present in one or more of the less clinically successful species. In contrast, when the accessory genome of an individual A. baumannii strain was compared to a strain of a less successful species (A. calcoaceticus RUH2202, many operons with putative virulence function were found to be present only in the A. baumannii strain, including the csu operon, the acinetobactin chromosomal cluster, and bacterial defence mechanisms. Phenotype microarray analysis showed that compared to A. calcoaceticus (RUH2202, A. baumannii ATCC 19606(T was able to utilise nitrogen sources more effectively and was more tolerant to pH, osmotic and antimicrobial stress. Virulence differences were also observed, with A. baumannii ATCC 19606(T, A. pittii SH024, and A. nosocomialis RUH2624 persisting and forming larger biofilms on human skin than A. calcoaceticus. A. baumannii ATCC 19606(T and A. pittii SH024 were also able to survive in a murine thigh infection model, whereas the other two species were eradicated. The current study provides important insights into the elucidation of differences in clinical relevance among Acinetobacter species.

  20. Cognitive performance and physiological changes in females at high G while protected with COMBAT EDGE and ATAGS.

    Science.gov (United States)

    Zhang, L

    1999-09-01

    Female fighter pilots are flying the F-16 and F-15 with COMBAT EDGE, the positive pressure breathing under G (PBG) protection system. The standard CSU 13 B/P anti-G suit may soon be replaced with the Advanced Technology Anti-G suit. The purpose of this research was to compare human performance and physiological changes between the subjects protected by COMBAT EDGE with the standard anti-G suit (STD) and with the Advanced Technology Anti-G Suit (ATAGS). Six female centrifuge subjects completed this experiment. Performance of the 3-min simulated aerial combat sorties on the Dynamic Environment Simulator. Heart rate, %SaO2 (percent arterial oxygen saturation), %rSO2 (percent regional cerebral tissue oxygen saturation) and electromyography (EMG) were compared between the two suit conditions. Subjective evaluations of the two suit conditions were also collected. No significant performance differences or EMG differences were found between the STD and ATAGS suits. In the ATAGS suit, %rSO2 and %SaO2 were significantly less and heart rate was significantly lower during the last minute of G exposure compared with the STD condition. Subjects rated the ATAGS suit as having provided better G tolerance, but more uncomfortable. The ATAGS were prototype suits, however, and were not custom fit to the women. Physiological changes did occur significantly during the last minute of G exposure, even though no significant performance differences were found between two suit conditions. Subjective comments supported the finding that the more G protection and body coverage afforded by the anti-G suit, the less comfortable the suit may be.

  1. New Program for New Faculty Mentoring at California State University, Chico

    Science.gov (United States)

    Teasdale, R.; McCarthy, K.; Phillips, C.; Silliman, K.; Fosen, C.; Thomas, M.

    2015-12-01

    CSU, Chico is a comprehensive university with high expectations for both teaching (4 courses per semester) and scholarly work. In an attempt to introduce faculty to their new positions, a two-day New Faculty Orientation has been offered for the last two decades. In AY 2014-15, in an attempt to improve the first year experience for new faculty, the Office of Faculty Affairs established and assessed a New Faculty Mentoring program. Eight college-based mentors were selected based on recommendations by College Deans who suggested successful teachers and scholars who could provide the social and leadership skills to effectively guide others. Based on a needs-assessment survey new faculty completed during orientation, mentors met with their new faculty cohort at least monthly to discuss campus resources, host workshops and provide other support in areas of time management, work-life balance, teaching pedagogies, discipline-specific internal and external funding resources, student support resources, and the preparation of Review/Retention documents. Mentors were paid a small stipend for their work and met twice each semester to discuss readings on mentoring best practices, their mentoring activities with new faculty and to compare the needs of their mentees. Survey results from 28 of 37 new faculty respondents indicate they valued Review/Retention workshops, mentor reviews of teaching and the opportunity to visit mentor classrooms for examples of good teaching practices. Social events helped establish cohorts, although some mentees indicated that some cohorts were too large. An unforeseen outcome was recognition that mid-year hires need to also be included in new faculty cohort groups. Moving forward, mentors will continue to work with their original mentees for a 2nd year. A new group of mentors will be identified for faculty starting in fall 2015 who will work with smaller first-year faculty cohorts and will coordinate with the first generation mentors for peer support.

  2. Microstructure Analysis of Directionally Solidified Aluminum Alloy Aboard the International Space Station

    Science.gov (United States)

    Angart, Samuel Gilbert

    This thesis entails a detailed microstructure analysis of directionally solidified (DS) Al-7Si alloys processed in microgravity aboard the International Space Station and similar duplicate ground based experiments at Cleveland State University. In recent years, the European Space Agency (ESA) has conducted experiments on alloy solidification in microgravity. NASA and ESA have collaborated for three DS experiments with Al- 7 wt. % Si alloy, aboard the International Space Station (ISS) denoted as MICAST6, MICAST7 and MICAST12. The first two experiments were processed on the ISS in 2009 and 2010. MICAST12 was processed aboard the ISS in the spring of 2014; the resulting experimental results of MICAST12 are not discussed in this thesis. The primary goal of the thesis was to understand the effect of convection in primary dendrite arm spacings (PDAS) and radial macrosegregation within DS aluminum alloys. The MICAST experiments were processed with various solidification speeds and thermal gradients to produce alloy with differences in microstructure features. PDAS and radial macrosegregation were measured in the solidified ingot that developed during the transition from one solidification speed to another. To represent PDAS in DS alloy in the presence of no convection, the Hunt-Lu model was used to represent diffusion-controlled growth. By sectioning cross-sections throughout the entire length of solidified samples, PDAS was measured and calculated. The ground-based (1-g) experiments done at Cleveland State University CSU were also analyzed for comparison to the ISS experiments (0-g). During steady state in the microgravity environment, there was a reasonable agreement between the measured and calculated PDAS. In ground-based experiments, transverse sections exhibited obvious radial macrosegregation caused by thermosolutal convection resulting in a non-agreement with the Hunt-Lu model. Using a combination of image processing techniques and Electron Microprobe Analysis

  3. Inverse PCR for subtyping of Acinetobacter baumannii carrying ISAba1.

    Science.gov (United States)

    Kim, Shukho; Park, Yun-Ju; Kim, Jungmin

    2016-05-01

    Acinetobacter baumannii has been prevalent in nosocomial infections, often causing outbreaks in intensive care units. ISAba1 is an insertion sequence that has been identified only in A. baumannii and its copy number varies among strains. It has been reported that ISAba1 provides a promoter for bla(OXA-51-like), bla(OXA-23-like), and bla(ampC), which are associated with the resistance of A. baumannii to carbapenems and cephalosporins. The main purpose of this study was to develop a novel inverse PCR method capable of typing A. baumannii strains. The method involves three major steps: cutting of genomic DNA with a restriction enzyme, ligation, and PCR. In the first step, bacterial genomic DNA was digested with DpnI. In the second step, the digested genomic DNAs were ligated to form intramolecular circular DNAs. In the last step, the ligated circular DNAs were amplified by PCR with primers specific for ISAba1 and the amplified PCR products were electrophoresed. Twenty-two clinical isolates of A. baumannii were used for the evaluation of the inverse PCR (iPCR) typing method. Dendrogram analysis revealed two major clusters, similar to pulsed-field gel electrophoresis (PFGE) results. Three ISAba1-associated genes--bla(ampC), bla(OXA-66-like), and csuD--were amplified and detected in the clinical isolates. This novel iPCR typing method is comparable to PFGE in its ability to discriminate A. baumannii strains, and is a promising molecular epidemiological tool for investigating A. baumannii carrying ISAba1.

  4. Impact of horizontal spatial resolution on the derivation of the source receptor relationship—an extra-tropical cyclone case

    Science.gov (United States)

    Lee, Jae-Bum; Lee, Tae-Young

    2004-11-01

    A numerical study has been made to evaluate the impact of horizontal resolution on the estimation of the source receptor (S R) relationship. Numerical experiments with four different horizontal grid sizes have been performed for an extra-tropical cyclonic episode in East Asia. CSU RAMS and YU-SADM (Yonsei University's sulfuric acid deposition model) have been used to simulate meteorological and pollutant fields, respectively.In this study, enhanced spatial resolution has improved the simulation of an extra-tropical cyclone, cold front and associated precipitation systems. As spatial resolution increases, the circulation associated with the cyclone and cold front becomes stronger, and the amount of frontal rainfall increases. This study has shown that enhancement of spatial resolution tends to increase self-contributions but decrease foreign contributions to the wet deposition associated with an extra-tropical cyclone. It has been found that increased precipitation for enhanced spatial resolution reduces the amount of transported pollutant but increases the wet deposition of locally emitted pollutants. The larger self-contribution for higher resolutions may also be partially due to the increased strength of resolved convection. The impact of enhancing spatial resolution on dry deposition is felt mostly over downstream regions where the centres of the lows and fronts pass. Contributions from upstream sources increase as cyclonic circulation becomes stronger with increasing spatial resolution. On the other hand, enhancing spatial resolution does not significantly affect the S R relationship for either dry or wet deposition in the other regions where the extra-tropical cyclone does not pass. This study indicates that improved simulation of a cold front does not significantly affect the S R relationship for wet deposition over the area of passage of the cold front. An additional discussion infers a S R relationship for the wet deposition associated with a typical extra

  5. Emergence of multidrug-resistant Acinetobacter baumannii producing OXA-23 Carbapenemase in Qatar

    Directory of Open Access Journals (Sweden)

    J.-M. Rolain

    2016-05-01

    Full Text Available The objective of our study was to describe the molecular support of carbapenem resistance from randomly selected clinical isolates of multidrug-resistant (MDR Acinetobacter baumannii as a pilot study from the Hamad Medical Corporation (HMC, Qatar. Results of our report will be used to study carbapenemases using molecular techniques in all isolated MDR A. baumannii. Forty-eight MDR A. baumannii were randomly selected from isolates preserved at HMC. Identification of all isolates was confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Antibiotic resistance was tested phenotypically by Phoenix and confirmed by Etest. The molecular support of carbapenemases (blaOXA-23, blaOXA-24, blaOXA-58, blaNDM was investigated by real-time PCR. The epidemiologic relatedness of the isolates was verified by phylogenetic analysis based on partial sequences of CsuE and blaOXA-51 genes. All 48 isolates were identified as A. baumannii and were confirmed to be resistant to most antibiotics, especially meropenem, imipenems, ciprofloxacin, levofloxacin, amikacin, gentamicin and most of the β-lactams; they were sensitive to colistin. All the isolates were positive for blaOXA-23 and negative for the other tested carbapenemase genes. Clonality analysis demonstrated that different lineages were actually circulating in Qatar; and we suggest that an outbreak occurred in the medical intensive care unit of HMC between 2011 and 2012. Here we report the emergence of MDR A. baumannii producing the carbapenemase OXA-23 in Qatar.

  6. Orbit Refinement of Asteroids and Comets Using a Robotic Telescope Network

    Science.gov (United States)

    Lantz Caughey, Austin; Brown, Johnny; Puckett, Andrew W.; Hoette, Vivian L.; Johnson, Michael; McCarty, Cameron B.; Whitmore, Kevin; UNC-Chapel Hill SKYNET Team

    2016-01-01

    We report on a multi-semester project to refine the orbits of asteroids and comets in our Solar System. One of the newest fields of research for undergraduate Astrophysics students at Columbus State University is that of asteroid astrometry. By measuring the positions of an asteroid in a set of images, we can reduce the overall uncertainty in the accepted orbital parameters of that object. These measurements, using our WestRock Observatory (WRO) and several other telescopes around the world, are being published through the Minor Planet Center (MPC) and benefit the global community.Three different methods are used to obtain these observations. First, we use our own 24-inch telescope at WRO, located in at CSU's Coca-Cola Space Science Center in downtown Columbus, Georgia . Second, we have access to data from the 20-inch telescope at Stone Edge Observatory in El Verano, California. Finally, we may request images remotely using Skynet, an online worldwide network of robotic telescopes. Our primary and long-time collaborator on Skynet has been the "41-inch" reflecting telescope at Yerkes Observatory in Williams Bay, Wisconsin. Thus far, we have used these various telescopes to refine the orbits of more than 15 asteroids and comets. We have also confirmed the resulting reduction in orbit-model uncertainties using Monte Carlo simulations and orbit visualizations, using Find_Orb and OrbitMaster software, respectively.Before any observatory site can be used for official orbit refinement projects, it must first become a trusted source of astrometry data for the MPC. We have therefore obtained Observatory Codes not only for our own WestRock Observatory (W22), but also for 3 Skynet telescopes that we may use in the future: Dark Sky Observatory in Boone, North Carolina (W38) Hume Observatory in Santa Rosa, California (U54) and Athabasca University Geophysical Observatory in Athabasca, Alberta, Canada (U96).

  7. Georgians Experience Astronomy Research in Schools: An Introduction

    Science.gov (United States)

    Webster, Zodiac T.; Aguilar, J. C.; Higdon, S. J. U.

    2010-01-01

    Georgia Department of Education and its partners at Columbus State and Georgia Southern Universities are engaged in creating a comprehensive program to institutionalize high quality astronomy in its high schools. The goal of the Georgians Experience Astronomy Research in Schools (GEARS) project is to transform the way high-school Astronomy is taught in 100% of GA's public schools by 2012. GEARS will be an innovative and rigorous, NASA research-infused Astronomy curriculum, which will reach thousands of students in rural, urban, and suburban areas and will be taught by highly trained teachers. GEARS project leaders have two objectives: 1) Develop and implement an online high-school Astronomy course for inclusion in the GA Virtual School portal. The GEARS course will be a progression through inquiry-based research experiences culminating in authentic data analysis and data mining activities selected from the NASA archives. The GEARS framework and units will meet the new Georgia Performance Standards in Astronomy and will be incorporated into teacher workshops. 2) Ensure the sustainability and utilization of GEARS both online and in a blended classroom approach by providing teacher professional development, integrating it into Space Science for Teachers graduate courses, and by developing a network of Georgia Astronomy Resource Teachers who will teach GEARS astronomy and mentor other teachers in their local areas. This poster will provide an overview of the workshop and course curricular framework, design philosophy and sample units. Partnerships with interested parties, especially those with NASA data, are sought. The project website is http://cheller.phy.georgiasouthern.edu/ shigdon/GEARS/GEARS.html. This project is funded by NASA Grant NNX09AH83A through the GADOE, supported by CSU and GSU.

  8. Resourcing speech-language pathologists to work with multilingual children.

    Science.gov (United States)

    McLeod, Sharynne

    2014-06-01

    Speech-language pathologists play important roles in supporting people to be competent communicators in the languages of their communities. However, with over 7000 languages spoken throughout the world and the majority of the global population being multilingual, there is often a mismatch between the languages spoken by children and families and their speech-language pathologists. This paper provides insights into service provision for multilingual children within an English-dominant country by viewing Australia's multilingual population as a microcosm of ethnolinguistic minorities. Recent population studies of Australian pre-school children show that their most common languages other than English are: Arabic, Cantonese, Vietnamese, Italian, Mandarin, Spanish, and Greek. Although 20.2% of services by Speech Pathology Australia members are offered in languages other than English, there is a mismatch between the language of the services and the languages of children within similar geographical communities. Australian speech-language pathologists typically use informal or English-based assessments and intervention tools with multilingual children. Thus, there is a need for accessible culturally and linguistically appropriate resources for working with multilingual children. Recent international collaborations have resulted in practical strategies to support speech-language pathologists during assessment, intervention, and collaboration with families, communities, and other professionals. The International Expert Panel on Multilingual Children's Speech was assembled to prepare a position paper to address issues faced by speech-language pathologists when working with multilingual populations. The Multilingual Children's Speech website ( http://www.csu.edu.au/research/multilingual-speech ) addresses one of the aims of the position paper by providing free resources and information for speech-language pathologists about more than 45 languages. These international

  9. A Research Experiences for Undergraduates program (REU) Program Designed to Recruit, Engage and Prepare a Diverse Student Population for Careers in Ocean Sciences.

    Science.gov (United States)

    Clarkston, B. E.; Garza, C.

    2016-02-01

    The problem of improving diversity within the Ocean Sciences workforce—still underperforming relative to other scientific disciplines—can only be addressed by first recruiting and engaging a more diverse student population into the discipline, then retaining them in the workforce. California State University, Monterey Bay (CSUMB) is home to the Monterey Bay Regional Ocean Science Research Experiences for Undergraduates (REU) program. As an HSI with strong ties to multiple regional community colleges and other Predominantly Undergraduate Institutions (PUIs) in the CSU system, the Monterey Bay REU is uniquely positioned to address the crucial recruitment and engagement of a diverse student body. Eleven sophomore and junior-level undergraduate students are recruited per year from academic institutions where research opportunities in STEM are limited and from groups historically underrepresented in the Ocean Sciences, including women, underrepresented minorities, persons with disabilities, and veterans. During the program, students engage in a 10-week original research project guided by a faculty research mentor in one of four themes: Oceanography, Marine Biology and Ecology, Ocean Engineering, and Marine Geology. In addition to research, students develop scientific self-efficacy and literacy skills through rigorous weekly professional development workshops in which they practice critical thinking, ethical decision-making, peer review, writing and oral communication skills. These workshops include tangible products such as an NSF-style proposal paper, Statement of Purpose and CV modelled for the SACNAS Travel Award Application, research abstract, scientific report and oral presentation. To help retain students in Ocean Sciences, students build community during the REU by living together in the CSUMB dormitories; post-REU, students stay connected through an online facebook group, LinkedIn page and group webinars. To date, the REU has supported 22 students in two

  10. Sequential electrolytic oxidation and reduction of aqueous phase energetic compounds.

    Science.gov (United States)

    Gilbert, David M; Sale, Tom C

    2005-12-01

    Contamination of soils and groundwater with energetic compounds has been documented at many former ammunition manufacturing plants and ranges. Recent research at Colorado State University (CSU) has demonstrated the potential utility of electrolytic degradation of organic compounds using an electrolytic permeable reactive barrier (e-barrier). In principle, an electrolytic approach to degrade aqueous energetic compounds such as hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) or 2,4,6-trinitrotoluene (TNT) can overcome limitations of management strategies that involve solely oxidation or reduction, through sequential oxidation-reduction or reduction-oxidation. The objective of this proof-of-concept research was to evaluate transformation of aqueous phase RDX and TNT in flow-through electrolytic reactors. Laboratory experiments were conducted using six identical column reactors containing porous media and expanded titanium-mixed-metal-oxide electrodes. Three columns tested TNT transformation and three tested RDXtransformation. Electrode sequence was varied between columns and one column for each contaminant acted as a no-voltage control. Over 97% of TNT and 93% of RDX was transformed in the reactors under sequential oxidation-reduction. Significant accumulation of known degradation intermediates was not observed under sequential oxidation-reduction. Removal of approximately 90% of TNT and 40% of RDX was observed under sequential reduction-oxidation. Power requirements on the order of 3 W/m2 were measured during the experiment. This suggests that an in-situ electrolytic approach may be cost-practical for managing groundwater contaminated with explosive compounds.

  11. Molecular Analysis and Expression of bap Gene in Biofilm-Forming Multi-Drug-Resistant Acinetobacter baumannii

    Directory of Open Access Journals (Sweden)

    Omid Azizi

    2016-10-01

    Full Text Available Background: Acinetobacter baumannii is commonly resistant to nearly all antibiotics due to presence of antibiotic resistance genes and biofilm formation. In this study we determined the presence of certain antibiotic-resistance genes associated with biofilm production and the influence of low iron concentration on expression of the biofilm-associated protein gene (bap in development of biofilm among multi-drug-resistant A. baumannii (MDRAB. Methods: Sixty-five MDRAB isolates from clinical samples were collected. Molecular typing was carried out by random amplified polymorphism DNA polymerase chain reaction (RAPD-PCR. Biofilm formation was assayed by the microtiter method. Results: The sequence of bap was determined and deposited in the GenBank database (accession no. KR080550.1. Expression of bap in the presence of low iron was analyzed by relative quantitative real time PCR (rqRT-PCR. Nearly half of the isolates belonged to RAPD-types A and B remaining were either small clusters or singleton. The results of biofilm formation revealed that 23 (35.4%, 18 (27.7%, 13 (20%, and 11 (16.9% of the isolates had strong, moderate, weak, and no biofilm activities, respectively. ompA and csuE genes were detected in all, while bap and blaPER-1 were detected in 43 (66% and 42 (64% of the isolates that showed strong and moderate biofilm activities (p ≤ 0.05, respectively. Analysis of bap expression by rqRT-PCR revealed five isolates with four-fold bap overexpression in the presence of low iron concentration (20 μM. Conclusion: The results suggest that bap overexpression may influence biofilm formation in presence of low iron concentration.

  12. Native American Indian Successes in Natural Resources, Science and Engineering: PreK through Ph.D.

    Science.gov (United States)

    Bolman, J. R.

    2005-12-01

    We are living in a definite time of change. Distinct changes are being experienced in our most sacred and natural environments. This is especially true on Native lands. Native people have lived for millennia in distinct and unique ways. The knowledge of balancing the needs of people with the needs of our natural environments is paramount in all tribal societies. This inherent knowledge has become the foundation on which to build a "blended" contemporary understanding of western science. The Dakota's and Northern California have recognized the critical need in understanding successful tribal strategies to engage educational systems (K-12 and higher education), to bring to prominence the professional development opportunities forged through working with tribal peoples and ensure the growth of Native people in STEM (Science, Technology, Engineering and Mathematics) professions. The presentation will highlight: 1) current philosophies on building a STEM Native workforce; 2) successful educational programs/activities in PreK-Ph.D. systems; 3) current Native professionals, their research and tribal applicability; and 4) forwarding thinking for creating sustainable environmental and social infrastructures for all people. South Dakota School of Mines and Technology (SDSM&T) and Humboldt State University (HSU) have been recognized nationally for their partnerships with Native communities. SDSM&T has set record numbers for graduating Native students in science and engineering. SDSM&T had 27 graduates in five years (2000-2005) and hosted more than 1000+ Native students for programs and activities. Humboldt State University is the only university in the CSU system with a program focusing specifically on Natives in natural resources, science and engineering as well as a Native American Studies degree. Both universities have designed programs to meet current needs and address challenging issues in Earth, Wind, Fire and Water. The programs are funded through NASA, NSF, NIH and

  13. Electrochemical Characterization of Semiconductor Materials and Structures

    Science.gov (United States)

    1997-01-01

    For a period covering October 1, 1995 through August 12, 1996, the research group at CSU has conducted theoretical and experimental research on "Electrochemical Characterization of Semiconductor Materials and Structures. " The objective of this investigation was to demonstrate the applicability of electrochemical techniques for characterization of complex device structures based on InP and GaAs, Ge, InGaAs, InSb, InAs and InSb, including: (1) accurate EC-V net majority carrier concentration depth profiling, and (2) surface and bulk structural and electrical type defect densities. Our motivation for this R&D effort was as follows: "Advanced space solar cells and ThermoPhotoVoltaic (TPV) cells are fabricated using a large variety of III-V materials based on InP and GaAs for solar cells and low bandgap materials such as Ge, InGaAs, InAs and InSb for TPV applications. At the present time for complex device structures using these materials, however, there is no simple way to assess the quality of these structures prior to device fabrication. Therefore, process optimization is a very time consuming and a costly endeavor". Completion of this R&D effort would have had unquestionable benefits for space solar cell and TPV cells, since electrochemical characterization of the above cell structures, if properly designed can provide many useful structural and electrical material information virtually at any depth inside various layers and at the interfaces. This, could have been applied for step-by-step process optimization, which could have been used for fabrication of new generation high efficiency, low cost space PV and TPV cells.

  14. Tracing Gas and Particle Phase Oxidation From Engine Sources as a Function of Fuel Type, Load, and Photochemical Age

    Science.gov (United States)

    Friedman, B.; Farmer, D.; Jathar, S.; Galang, A.; Fulgham, R.; Link, M.; Brophy, P.

    2015-12-01

    Motor vehicle emissions are an important source of anthropogenic gases and particles in the atmosphere. To study the gas and particle phase emissions, an HR-TOF-AMS and HR-TOF-CIMS were deployed at the CSU Engines Lab, along with an oxidative flow reactor, to measure emissions from a 4.5 L John Deere engine, which ran either diesel or biodiesel fuel. Concurrent gas-phase and particle-phase measurements allowed determination of the gas-phase and particle-phase oxidation properties as a function of fuel type, fuel load, and photochemical age. The impacts of particulate filers on composition and oxidation state were also assessed. While aerosol composition and associated oxidation properties for the biodiesel and diesel fuel types were similar, differences in photochemical production existed for the amount of load, or efficiency of the engine. The mean particulate oxygen to carbon ratios (O:C) and mean hydrogen to carbon ratios (H:C) moved from an initial 0.1 and 2 to a final 0.55 and 1.6, respectively, upon idle biodiesel and diesel engine exhaust exposure to approximately 7 days of OH exposure. The more efficient higher load biodiesel and diesel engine exhaust experienced less changes in the mean O:C and H:C values (an initial 0.1 and 2 to a final 0.3 and 1.7, respectively) with approximately the same amount of OH exposure. Despite largely scrubbing the majority of particles from the engine exhaust, experiments with engine particulate filters still showed photochemical production of oxidized particle-phase species at high photochemical ages, similar to that of idle engine exhaust without any particulate filters. Bulk gas-phase data was compared to bulk aerosol data in Van Krevelen space in order to understand how particle-phase oxidation traces gas-phase oxidation as a function of fuel type, engine load, and photochemical age.

  15. H1-antihistamines for chronic spontaneous urticaria.

    Science.gov (United States)

    Sharma, Maulina; Bennett, Cathy; Cohen, Stuart N; Carter, Ben

    2014-11-14

    Background Chronic spontaneous urticaria (CSU) is characterised by the development of crops of red, itchy, raised weals or hives with no identifiable external cause.Objectives To assess the effects of H1-antihistamines for CSU.Search methods We searched the following databases up to June 2014: Cochrane Skin Group Specialised Register, CENTRAL (2014, Issue 5), MEDLINE(from 1946), EMBASE (from 1974) and PsycINFO (from 1806). We searched five trials registers and checked articles for references to relevant randomised controlled trials.Selection criteria We included randomised controlled trials of H1-antihistamines for CSU. Interventions included single therapy or a combination of H1-antihistamines compared with no treatment (placebo) or another active pharmacological compound at any dose.Data collection and analysis We used standard methodological procedures as expected by The Cochrane Collaboration.Our primary outcome measures were proportion of participants with complete suppression of urticaria: 'good or excellent' response,50% or greater improvement in quality of life measures, and adverse events.We present risk ratios (RR) with 95% confidence intervals(CIs). Main results We identified 73 studies (9759 participants); 34 studies provided data for 23 comparisons. The duration of the intervention was up to two weeks (short-term) or longer than two weeks and up to three months (intermediate-term).Cetirizine 10mg once daily in the short term and in the intermediate term led to complete suppression of urticaria by more participants than was seen with placebo (RR 2.72, 95% CI 1.51 to 4.91). For this same outcome, comparison of desloratadine versus placebo in the intermediate term (5 mg) (RR 37.00, 95% CI 2.31 to 593.70) and in the short term (20 mg) (RR 15.97, 95% CI 1.04 to 245.04)favoured desloratadine, but no differences were seen between 5 mg and 10 mg for short-term treatment.Levocetirizine 20 mg per day (short-term) was more effective for complete suppression of

  16. The Role of Deforestation in the Collapse of Classic Maya Civilization: Lessons for the Current Land Use Management in Northern Mesoamerica

    Science.gov (United States)

    Ray, D. K.; Nair, U. S.; Welch, R. M.; Lawton, R. O.; Oglesby, R. J.; Pielke, R. A.; Sever, T. A.; Irwin, D.

    2005-12-01

    The classic Maya civilization produced thriving cities that attained population densities comparable to modern day cities during the zenith of its growth approximately around 750 A.D. The Mayan civilization then experienced a catastrophic collapse between 750-950 A.D. Among the various hypothesis forwarded to explain the sudden collapse, one that has recently attracted attention, is the role of deforestation and decreases of regional rainfall that could have affected the day-to-day lives of the ancient Mayas. Deep-rooted rainforest vegetation has access to water stored in deep soil layers, and this deep water is made available to the hydrological cycle through transpiration. Removal of rainforests for agricultural purposes, which is accompanied by soil compaction and reduction in the organic material at the surface, leads to increased runoff and decreased soil water storage. Shallow-rooted vegetation that replaces the deep-rooted rainforests cannot efficiently access the moisture in the deep soil layers, reducing flux of water vapor to the atmosphere. In this study the Colorado State University Regional Atmospheric Modeling System (CSU RAMS) is utilized to examine differences in precipitation between current and forested conditions and between current and deforested conditions similar to those that archaeologists believe were prevalent prior to the collapse. Moreover, current deforestation rates in this region is converting the landscape into one that is similar to those prior to the Maya collapse. The simulated rainfall is compared against climatological rain gauge rainfall values. The statistical scores such as probability of detection, false alarm ratio, and the threat scores all compare favorably with those reported in the literature. Our results suggest that with the removal of forests the rainfall can be expected to decrease by 10 to 100mm in the Maya lowlands. Averaged over the entire Maya lowlands region, dry season rainfall for the forested conditions is

  17. Development of a polarimetric radar based hydrometeor classification algorithm for winter precipitation

    Science.gov (United States)

    Thompson, Elizabeth Jennifer

    The nation-wide WSR-88D radar network is currently being upgraded for dual-polarized technology. While many convective, warm-season fuzzy-logic hydrometeor classification algorithms based on this new suite of radar variables and temperature have been refined, less progress has been made thus far in developing hydrometeor classification algorithms for winter precipitation. Unlike previous studies, the focus of this work is to exploit the discriminatory power of polarimetric variables to distinguish the most common precipitation types found in winter storms without the use of temperature as an additional variable. For the first time, detailed electromagnetic scattering of plates, dendrites, dry aggregated snowflakes, rain, freezing rain, and sleet are conducted at X-, C-, and S-band wavelengths. These physics-based results are used to determine the characteristic radar variable ranges associated with each precipitation type. A variable weighting system was also implemented in the algorithm's decision process to capitalize on the strengths of specific dual-polarimetric variables to discriminate between certain classes of hydrometeors, such as wet snow to indicate the melting layer. This algorithm was tested on observations during three different winter storms in Colorado and Oklahoma with the dual-wavelength X- and S-band CSU-CHILL, C-band OU-PRIME, and X-band CASA IP1 polarimetric radars. The algorithm showed success at all three frequencies, but was slightly more reliable at X-band because of the algorithm's strong dependence on KDP. While plates were rarely distinguished from dendrites, the latter were satisfactorily differentiated from dry aggregated snowflakes and wet snow. Sleet and freezing rain could not be distinguished from rain or light rain based on polarimetric variables alone. However, high-resolution radar observations illustrated the refreezing process of raindrops into ice pellets, which has been documented before but not yet explained. Persistent

  18. Response of a veterinary college to career development needs identified in the KPMG LLP study and the executive summary of the Brakke study: a combined MBA/DVM program, business certificate program, and curricular modifications.

    Science.gov (United States)

    Kogan, Lori R; McConnell, Sherry L; Schoenfeld-Tacher, Regina

    2005-04-01

    marketing skills than that reported by males. As a result of these pressing needs, CSU CVMBS has undertaken a major initiative to improve the veterinary practice management and business skills training of veterinary students by offering a variety of options to gain this knowledge: a combined MBA/DVM degree program, a Business Certificate Program for Health Professions, and core curriculum courses. In this way, students can select the amount of focus they want to place on career development and business skills as they earn their DVM degree, to best ensure that they become successful veterinarians.

  19. Occurrence and spatial distribution of intestinal parasites in an agricultural center in Paraná State, Brazil = Ocorrência e distribuição espacial de parasitos intestinais em polo agrícola, Estado do Paraná, Brasil

    Directory of Open Access Journals (Sweden)

    Dina Lúcia Moraes Falavigna

    2010-07-01

    Full Text Available We determined the occurrence of human cases of intestinal parasites and their spatial distribution in an agricultural center of the state of Paraná in southern Brazil. Results from 5,219 stool examinations carried out in 2003 and 2004 in public and private clinical-pathologylaboratories were analyzed. The overall occurrence of intestinal parasites was 19.8%. Entamoeba coli (7.2% and Giardia duodenalis (5.2% were the most frequent species. E. coli was present in 36.4%, G. duodenalis in 26.2% and E. nana in 13.6% of positive cases. According to spatial distribution, the highest occurrence of intestinal parasites was observed in the Piquiri/Guarujá area (p O objetivo deste trabalho foi determinar a ocorrência de casos humanos e a distribuição espacial de parasitos intestinais em município agroindustrial do Estado do Paraná, Sul do Brasil. Foram investigados resultados de 5.219 exames coproparasitológicos realizados em 2003 e 2004, em laboratórios de Análises Clínicas da rede pública e privada. A ocorrência de parasitos intestinais foi de 19,8%, sendo Entamoeba coli (7,2% e Giardia duodenalis (5,2% as espécies mais encontradas. Entre os resultados positivos E. coli estava presente em 36,4%, G. duodenalis em 26,2% e E. nana em 13,6%. A mais alta ocorrência de parasitos intestinais foi observada na área do Piquiri/Guarujá (p < 0,05 e a mais baixa no CSU, Urupês e Paulista. No Piquiri/Guarujá, as espécies mais frequentes foram G. duodenalis (22,2% e E. coli (7,4%. Diferenças significativas na ocorrência de enteroparasitos foram observadas para o gênero feminino (p < 0,05 e para a faixa etária de zero a dez anos (p < 0,05. A ocorrência de parasitos intestinais no município está mais relacionada às crianças, ao gênero feminino e à área que apresenta características rurais e de periferia de centros urbanos onde o risco de infecção é maior. Esta informação irá permitir o desenvolvimento de medidas apropriadas para

  20. Undergraduate Research as a Process for STEM Teaching and Learning Systemic Change: Lessons Learned from the Council on Undergraduate Research NSF CCLI and TUES Projects

    Science.gov (United States)

    Ambos, E. L.; Havholm, K. G.; Malachowski, M.; Osborn, J.; Karukstis, K.

    2013-12-01

    For more than seven years, the Council on Undergraduate Research (CUR), the primary organization supporting programs, services, and advocacy for undergraduate research, has been working with support from the NSF's Division of Undergraduate Education (DUE) to enhance, sustain, and institutionalize undergraduate research in diverse STEM disciplines and higher education settings. The Council on Undergraduate Research comprises more than 9000 individual and 670 institutional members within a divisional structure that includes geosciences, as well as 11 other thematic areas. Through its most recent grant: 'Transformational Learning through Undergraduate Research: Comprehensive Support for Faculty, Institutions, State Systems and Consortia' (NSF DUE CCLI III Award #09-20275), CUR has been collaborating with six higher education systems, each selected after a rigorous national application process in 2010 and 2011. These six systems, which collectively represent 79 individual institutions, are the Council of Public Liberal Arts Colleges (COPLAC), University of Wisconsin System (UWS), California State University System (CSU), City University of New York (CUNY), Great Lakes Colleges Association (GLCA), and Pennsylvania State System of Higher Education (PASSHE). The more than 350 participants of faculty and senior-level administrators from the six systems are engaged in shared multi-faceted and multi-year professional development experiences. Teams from each system attended customized institutes facilitated by CUR experts in 2011-2012, during which the teams developed specific action plans focused on institutionalizing undergraduate research on their campus and within their system. The systems were reconvened as a group a year after the first institute, to chart progress toward achieving their goals. Based on interviews and surveys with participants, campus teams are making substantial progress toward implementation of robust undergraduate research programs, and are making

  1. 慢性自发性荨麻疹患者血清IL-35及IL-26水平的变化

    Institute of Scientific and Technical Information of China (English)

    肖常青; 邓景航; 罗育武; 王菲

    2016-01-01

    目的 分析慢性自发性荨麻疹(CSU)患者外周血血清中白细胞介素(IL)-35及IL-26水平的变化.方法 选择90例CSU患者为观察组,并分为活动期CSU组和静止期CSU组2个亚组,每组45例;选择同期健康体检者60例为对照组.各组均采用酶联免疫吸附试验进行IL-35及IL-26水平的检测,并对检测结果进行比较.结果 观察组IL-35水平明显高于对照组,IL-26水平明显低于对照组(均P<0.05),活动期CSU组、静止期CSU组IL-35水平均高于对照组,活动期CSU组高于静止期CSU组(均P<0.05);活动期CSU组IL-26水平明显低于对照组(P<0.05),活动期CSU组与静止期CSU组、静止期CSU组与对照组的IL-26水平比较差异均无统计学意义(均P>0.05).采用Spearman进行相关检验示,CSU患者的IL-35水平与症状评分呈正相关(r=0.74,P<0.01),与病程无明显相关性(r=0.23,P>0.05);IL-26水平与症状评分呈负相关(r=-0.24,P<0.05),与病程无明显相关性(r=-0.15,P>0.05).结论 在CSU的发病过程中,IL-35及IL-26水平变化具有重要作用.

  2. Improvement in the quality of life of patients with chronic spontaneous urticaria treated with omalizumab in real life.

    Science.gov (United States)

    Larrea-Baca, Itzíar; Gurpegui-Resano, María

    2017-04-27

    Evaluation of the impact on the quality of life (QOL) relating to health in patients with chronic urticaria (CSU) treated with omalizumab. Longitudinal descriptive observational study of quality of life based on18 patients with chronic urticaria ≥12 years treated with omalizumab. Changes in QOL examined at 1 month (T1), at 6 months (T6) and 12 months (T12), by: Visual Analogical Scale (UAS), specific urticaria QOL questionnaire (CU-Q2oL), general health questionnaire (SF-36) and activity of urticaria questionnaire (Score UAS7). The most disabling symptoms for patients were: pruritus (61.1%); decrease in health and physical activity (55.5%), wheals, swelling and nervousness (50%); depression and shame of marks (38.89%); side effects to drugs (33.33%); sleepiness and tiredness (27.78%); work (22.22%); "choosing clothes and pain" 16.67% and social relations (11.11%). Statistically significant differences were observed in T1, T6 and T12. In T1, UAS -4.72 (p=.001); CU-Q2oL -16.38 (p<.001); SF-36 15.44 (p=.006); UAS7 wheals -7.27 (p=.001), UAS7 pruritus -8.72 (p=.003). In T6, UAS -4.26 (p=.001); CU-Q2oL -18.94 (p<.001); SF-36 15.41 (p<.001); UAS7 wheals -7.41 (p=.001), UAS7 pruritus -7.11 (p=.001). In T12 UAS -9.61 (p=.004); CU-Q2oL -21.38 (p=.01); SF-36 17.53 (p=.04); UAS7 wheals -8.23 (p=.004), UAS7 pruritus -10.69 (p=.004). There was a very good response in T1, which was maintained in T6 and T12. Patients with chronic urticaria treated with omalizumab presented good results with a reduction of CUE activity and improvement of their QOL. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  3. The Tulare Lake Project: A 35,000-year record of lake level constraining precipitation and stream discharge from the southern Sierra Nevada of California, USA

    Science.gov (United States)

    Negrini, R. M.

    2015-12-01

    Building upon earlier works by Harding (1949), Atwater et al. (1986) and Davis (1999), research centered at CSU Bakersfield over the past 15 years has generated a high resolution paleoclimate history with water resource implications for one of the world's great agricultural centers, the San Joaquin Valley of California. Lake level is based upon aerial mapping of geomorphological features (e.g., sand spits and shorelines), lithologic features exposed in trenches from opposite sides of the lake basin (e.g., marsh deposits), and proxy data from core (e.g., clay %). Age control was provided by radiocarbon dating of charcoal, mussel shells, and bulk organic matter and by paleomagnetic secular variation dating. From oldest to youngest, highlights include: 1. millennial-scale variations at the base of the record, 2. evidence for avulsion of the Kings River into Tulare Lake at or near the time of maximum glaciation in the Sierra Nevada as predicted by Weissman et al. (2005), 3. lake-level changes during the early and middle Holocene that vary in tune with eastern Pacific sea-surface temperatures from marine core records. This includes an unusually wet period starting at 12,500 cal B.P. followed by a dramatic, rapid drop in lake level at 7,500 cal B.P. Evidence for the former feature includes geochemical (leaf wax n-alkane markers for grass) and petrographic (grass phytolith) data. The latter feature represents an abrupt decrease in Sierran Stream discharge equal to several millions of acre-ft/yr. 4. A centuries-long increase in lake level commencing in the 13th or 14th century based on both lake-level reconstructions from the LBDA of Cook et al. (2010) and dated fine-grained sediments exposed in high-elevation trenches (Negrini et al., 2006), 5. A flood deposit identified in the uppermost sediments exposed in the southeastern edge of the lake that has a radiocarbon age consistent with that of an early 17th century flood found in the sediments of the Santa Barbara Channel

  4. Numerical and Observational Investigations of Long-Lived Mcs-Induced Severe Surface Wind Events: the Derecho

    Science.gov (United States)

    Schmidt, Jerome Michael

    This study addresses the production of sustained, straight-line, severe surface winds associated with mesoscale convective systems (MCSs) of extratropical origin otherwise known as derechos. The physical processes which govern the observed derecho characteristics are identified and their possible forcing mechanisms are determined. Detailed observations of two derechos are presented along with simulations using the Colorado State University Regional Atmospheric Modeling System (CSU-RAMS). The observations revealed a derecho environment characterized by strong vertical wind shear through the depth of the troposphere and large values of convective available potential energy (CAPE). The thermodynamic environment of the troposphere in each case had a distinct three-layer structure consisting of: (i) a surface-based stable layer of 1-to-2 km in depth, (ii) an elevated well -mixed layer of 2-4 km in depth, and (iii) an upper tropospheric layer of intermediate stability that extended to the tropopause. Two primary sets of simulations were performed to assess the impact of the observed environmental profiles on the derecho structure, propagation, and longevity. The first set consisted of nested-grid regional-scale simulations initialized from the standard NMC analyses on a domain having relatively coarse horizontal resolution (75 km). The second set of simulations consisted of two and three-dimensional experiments initialized in a horizontally homogeneous environment having a relatively fine horizontal resolution (2 km) and explicit microphysics. The results from these experiments indicate the importance of convectively -induced gravity waves on the MCS structure, propagation, longevity, and severe surface wind development. The sensitivity of the simulated convection and gravity waves to variations in the vertical wind shear and moisture profiles are described. Detailed Doppler radar analyses and 3-D simulations of a severe, bow echo squall line are presented which reveal

  5. STATISTICAL PROPERTIES OF LONG-RANGE CONTACTS IN GLOBULAR PROTEINS

    Institute of Scientific and Technical Information of China (English)

    Xiang-hong Wang; Jian-hong Ke; Mang-xiao Hu

    2004-01-01

    The analysis of residue-residue contacts in protein structures can shed some light on our understanding of the folding and stability of proteins. In this paper, we study the statistical properties of long-range and short-range residueresidue contacts of 91 globular proteins using CSU software and analyze the importance of long-range contacts in globular protein structure. There are many short-range and long-range contacts in globular proteins, and it is found that the average number of long-range contacts per residue is 5.63 and the percentage of residue-residue contacts which are involved in longrange ones is 59.4%. In more detail, the distribution of long-range contacts in different residue intervals is investigated and it is found that the residues occurring in the interval range of 4-10 residues apart in the sequence contribute more long-range contacts to the stability of globular protein. The number of long-range contacts per residue, which is a measure of ability to form residue-residue contacts, is also calculated for 20 different amino acid residues. It is shown that hydrophobic residues (including Leu, Val, Ile, Met, Phc, Tyr, Cys and Trp) having a large number of long-range contacts easily form long-range contacts, while the hydrophilic amino acids (including Ala, Gly, Thr, His, Glu, Gin, Asp, Asn, Lys, Ser, Arg, and Pro) form long-range contacts with more difficulty. The relationship between the Fauchere-Pliska hydrophobicity scale (FPH) and the number of short-range and long-range contacts per residue for 20 amino acid residues is also studied. An approximately linear relationship between the Fauchere-Pliska hydrophobicity scale (FPH) and the number of long-range contacts per residue CL is found and can be expressed as CiL= a + b x FPHwhere a = 5.04 and b = 1.23. These results can help us to understand the role of residue-residue contacts in globular protein structure.

  6. Mesoscale energetics and flows induced by sea-land and mountain-valley contrasts

    Directory of Open Access Journals (Sweden)

    S. Federico

    Full Text Available We study the relative importance of sea-land and mountain-valley thermal contrasts in determining the development of thermally forced mesoscale circulations (TFMCs over a mountainous peninsula. We first analyse the energetics of the problem, and using this theory, we interprete the numerical simulations over Calabria, a mountainous peninsula in southern Italy. The CSU 3-D nonlinear numerical model is utilised to simulate the dynamics and the thermodynamics of the atmospheric fields over Calabria. Results show the importance of orography in determining the pattern of the flow and the local climate in a region as complex as Calabria. Analysis of the results shows that the energetics due to the sea-land interactions are more efficient when the peninsula is flat. The importance of the energy due to the sea-land decreases as the mountain height of the peninsula increases. The energy stored over the mountain gains in importance, untill it is released by the readjustment of the warm mountain air as it prevails over the energy released by the inland penetration of the sea breeze front. For instance, our results show that over a peninsula 100 km wide the energy over the mountain and the energy in the sea-land contrast are of the same order when the height of the mountain is about 700 m, for a 1500 m convective boundary layer (CBL depth. Over the Calabrian peninsula, the energy released by the hot air in the CBL of the mountain prevails over the energy released by the inland penetration of the sea air. Calabria is about 1500 m high and about 50 km wide, and the CBL is of the order of 1500 m. The energy over the mountain is about four time larger than the energy contained in the sea-land contrast. Furthermore, the energetics increase with the patch width of the peninsula, and when its half width is much less than the Rossby radius, the MAPE of the sea breeze is negligible. When its half width is much larger than the Rossby radius, the breezes from the two

  7. Lightning in Colorado forest fire smoke plumes during summer 2012

    Science.gov (United States)

    Lang, T. J.; Krehbiel, P. R.; Dolan, B.; Lindsey, D.; Rutledge, S. A.; Rison, W.

    2012-12-01

    May and June 2012 were unusually hot and dry in Colorado, which was suffering from a strong drought. A major consequence of this climatic regime was one of the most destructive forest fire seasons in state history, with hundreds of thousands of acres of forest and grassland consumed by flames, hundreds of homes burned, and several lives lost. Many of these fires occurred within range of the newly installed Colorado Lightning Mapping Array (COLMA), which provides high-resolution observations of discharges over a large portion of the state. The COLMA was installed in advance of the Deep Convective Clouds and Chemistry (DC3) project. High-altitude lightning was observed to occur sporadically in the smoke plumes over three major fires that occurred during early summer: Hewlett Gulch, High Park, and Waldo Canyon. Additionally, the Colorado State University CHILL (CSU-CHILL) and Pawnee radars observed the Hewlett Gulch plume electrify with detailed polarimetric and dual-Doppler measurements, and also provided these same measurements for the High Park plume when it was not producing lightning. Meanwhile, local Next Generation Radars (NEXRADs) provided observations of the electrified High Park and Waldo Canyon plumes. All of these plumes also were observed by geostationary meteorological satellites. These observations provide an unprecedented dataset with which to study smoke plume and pyrocumulus electrification. The polarimetric data - low reflectivity, high differential reflectivity, low correlation coefficient, and noisy differential phase - were consistent with the smoke plumes and associated pyrocumulus being filled primarily with irregularly shaped ash particles. Lightning was not observed in the plumes until they reached over 10 km above mean sea level, which was an uncommon occurrence requiring explosive fire growth combined with increased meteorological instability and reduced wind shear. Plume updraft intensification and echo-top growth led the occurrence of

  8. International aspirations for speech-language pathologists' practice with multilingual children with speech sound disorders: development of a position paper.

    Science.gov (United States)

    McLeod, Sharynne; Verdon, Sarah; Bowen, Caroline

    2013-01-01

    A major challenge for the speech-language pathology profession in many cultures is to address the mismatch between the "linguistic homogeneity of the speech-language pathology profession and the linguistic diversity of its clientele" (Caesar & Kohler, 2007, p. 198). This paper outlines the development of the Multilingual Children with Speech Sound Disorders: Position Paper created to guide speech-language pathologists' (SLPs') facilitation of multilingual children's speech. An international expert panel was assembled comprising 57 researchers (SLPs, linguists, phoneticians, and speech scientists) with knowledge about multilingual children's speech, or children with speech sound disorders. Combined, they had worked in 33 countries and used 26 languages in professional practice. Fourteen panel members met for a one-day workshop to identify key points for inclusion in the position paper. Subsequently, 42 additional panel members participated online to contribute to drafts of the position paper. A thematic analysis was undertaken of the major areas of discussion using two data sources: (a) face-to-face workshop transcript (133 pages) and (b) online discussion artifacts (104 pages). Finally, a moderator with international expertise in working with children with speech sound disorders facilitated the incorporation of the panel's recommendations. The following themes were identified: definitions, scope, framework, evidence, challenges, practices, and consideration of a multilingual audience. The resulting position paper contains guidelines for providing services to multilingual children with speech sound disorders (http://www.csu.edu.au/research/multilingual-speech/position-paper). The paper is structured using the International Classification of Functioning, Disability and Health: Children and Youth Version (World Health Organization, 2007) and incorporates recommendations for (a) children and families, (b) SLPs' assessment and intervention, (c) SLPs' professional

  9. Regional Ecosystem-Atmosphere CO2 Exchange Via Atmospheric Budgets

    Energy Technology Data Exchange (ETDEWEB)

    Davis, K J; Richardson, S J; Miles, N L

    2007-03-07

    are captured. Influence functions, derived using a Lagrangian Particle Dispersion model driven by the CSU Regional Atmospheric Modeling System and nudged to NCEP reanalysis meteorological fields, are used to determine source regions for the towers. The influence functions are combined with satellite vegetation observations to interpret the observed trends in CO2 concentration. Full inversions will combine these elements in a more formal analytic framework.

  10. Rainfall Estimation and Performance Characterization Using an X-band Dual-Polarization Radar in the San Francisco Bay Area

    Science.gov (United States)

    Cifelli, R.; Chen, H.; Chandra, C. V.

    2016-12-01

    The San Francisco Bay area is home to over 5 million people. In February 2016, the area also hosted the NFL Super bowl, bringing additional people and focusing national attention to the region. Based on the El Nino forecast, public officials expressed concern for heavy rainfall and flooding with the potential for threats to public safety, costly flood damage to infrastructure, negative impacts to water quality (e.g., combined sewer overflows) and major disruptions in transportation. Mitigation of the negative impacts listed above requires accurate precipitation monitoring (quantitative precipitation estimation-QPE) and prediction (including radar nowcasting). The proximity to terrain and maritime conditions as well as the siting of existing NEXRAD radars are all challenges in providing accurate, short-term near surface rainfall estimates in the Bay area urban region. As part of a collaborative effort between the National Oceanic and Atmospheric Administration (NOAA) Earth System Research Laboratory, Colorado State University (CSU), and Santa Clara Valley Water District (SCVWD), an X-band dual-polarization radar was deployed in Santa Clara Valley in February of 2016 to provide support for the National Weather Service during the Super Bowl and NOAA's El Nino Rapid Response field campaign. This high-resolution radar was deployed on the roof of one of the buildings at the Penitencia Water Treatment Plant. The main goal was to provide detailed precipitation information for use in weather forecasting and assists the water district in their ability to predict rainfall and streamflow with real-time rainfall data over Santa Clara County especially during a potentially large El Nino year. The following figure shows the radar's coverage map, as well as sample reflectivity observations on March 06, 2016, at 00:04UTC. This paper presents results from a pilot study from February, 2016 to May, 2016 demonstrating the use of X-band weather radar for quantitative precipitation

  11. The GLOBE Program 10 Years On: Challenges and Opportunities

    Science.gov (United States)

    Blurton, C.

    2004-12-01

    The initiative for the GLOBE Program, a hands-on primary and secondary school-based Earth science and education program that unites students, teachers and scientists in study and research about the dynamics of the Earth's environment, was first announced on Earth Day, April 22, 1994, by then-Vice President Al Gore. The U.S. National Oceanic and Atmospheric Administration (NOAA) was designated as GLOBE's lead agency. Along with NOAA, the National Aeronautics and Space Administration (NASA), the National Science Foundation (NSF), and the Environmental Protection Agency (EPA) provided funding, and the Department of State, although not a funding agency, was involved in the development and implementation of the international aspects of the program. The US Agency for International Development (USAID) and the Peace Corps have also provided support to GLOBE in other countries. GLOBE started up with just a few hundred schools and teachers but quickly grew over the years largely through the efforts of the growing number of International Partners and U.S. Partners such as universities, school districts and others. In December 2003, over 25,000 teachers in more than 14,500 schools in 105 countries had been trained to implement GLOBE in their classrooms. Students in those classrooms had contributed over 11,000,000 individual environmental measurements to the GLOBE database. In September 2002, NASA assumed lead U.S. federal agency responsibility for GLOBE and shortly thereafter issued a Cooperative Agreement Notice to solicit proposals to assume responsibility in assisting NASA in the management of the GLOBE Program, including both worldwide implementation and coordination in the U.S. A Cooperative Agreement between NASA and the University Corporation for Atmospheric Research (UCAR) for the Program entitled: Inspiring the Next Generation of Explorers: The GLOBE Program (NCC5-735) was signed June 16, 2003. UCAR's partner in implementing GLOBE is Colorado State University (CSU

  12. An Evaluation of Lightning Flash Rate Parameterizations Based on Observations of Colorado Storms during DC3

    Science.gov (United States)

    Basarab, B.; Fuchs, B.; Rutledge, S. A.

    2013-12-01

    Predicting lightning activity in thunderstorms is important in order to accurately quantify the production of nitrogen oxides (NOx = NO + NO2) by lightning (LNOx). Lightning is an important global source of NOx, and since NOx is a chemical precursor to ozone, the climatological impacts of LNOx could be significant. Many cloud-resolving models rely on parameterizations to predict lightning and LNOx since the processes leading to charge separation and lightning discharge are not yet fully understood. This study evaluates predicted flash rates based on existing lightning parameterizations against flash rates observed for Colorado storms during the Deep Convective Clouds and Chemistry Experiment (DC3). Evaluating lightning parameterizations against storm observations is a useful way to possibly improve the prediction of flash rates and LNOx in models. Additionally, since convective storms that form in the eastern plains of Colorado can be different thermodynamically and electrically from storms in other regions, it is useful to test existing parameterizations against observations from these storms. We present an analysis of the dynamics, microphysics, and lightning characteristics of two case studies, severe storms that developed on 6 and 7 June 2012. This analysis includes dual-Doppler derived horizontal and vertical velocities, a hydrometeor identification based on polarimetric radar variables using the CSU-CHILL radar, and insight into the charge structure using observations from the northern Colorado Lightning Mapping Array (LMA). Flash rates were inferred from the LMA data using a flash counting algorithm. We have calculated various microphysical and dynamical parameters for these storms that have been used in empirical flash rate parameterizations. In particular, maximum vertical velocity has been used to predict flash rates in some cloud-resolving chemistry simulations. We diagnose flash rates for the 6 and 7 June storms using this parameterization and compare

  13. The Colorado Lightning Mapping Array

    Science.gov (United States)

    Rison, W.; Krehbiel, P. R.; Thomas, R. J.; Rodeheffer, D.; Fuchs, B.

    2012-12-01

    A fifteen station Lightning Mapping Array (LMA) was installed in northern Colorado in the spring of 2012. While the driving force for the array was to produce 3-dimensional lightning data to support the Deep Convective Clouds and Chemistry (DC3) Experiment (Barth, this conference), data from the array are being used for several other projects. These include: electrification studies in conjunction with the CSU CHILL radar (Lang et al, this conference); observations of the parent lightning discharges of sprites (Lyons et al, this conference); trying to detect upward discharges triggered by wind turbines, characterizing conditions in which aircraft flying through clouds produce discharges which can be detected by the LMA, and other opportunities, such as observations of lightning in pyrocumulus clouds produced by the High Park Fire west of Fort Collins, CO. All the COLMA stations are solar-powered, and use broadband cellular modems for data communications. This makes the stations completely self-contained and autonomous, allowing a station to be installed anywhere a cellular signal is available. Because most of the stations were installed well away from anthropogenic noise sources, the COLMA is very sensitive. This is evidenced by the numerous plane tracks detected in its the vicinity. The diameter, D, of the COLMA is about 100 km, significantly larger than other LMAs. Because the error in the radial distance r is proportional to (r/D)2, and the error in the altitude z is proportional to (z/D)2, the larger array diameter greatly expands the usable range of the COLMA. The COLMA is able to detect and characterize lighting flashes to a distance of about 350 km from the array center. In addition to a web-based display (lightning.nmt.edu/colma), geo-referenced images are produced and updated at one-minute intervals. These geo-referenced images can be used to overlay the real-time lightning data on Google Earth and other mapping software. These displays were used by the DC3

  14. The location selection act or 'the Emperor's new clothes'; Das Standortauswahlgesetz oder 'Des Kaisers neue Kleider'

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2013-10-15

    As is generally known, the governing parties CDU/CSU and FDP agreed a few weeks ago in the 17{sup th} legislative period of the German Bundestag in a rare show of unanimity, together with the parties SPD and Buendnis 90/Die Gruenen, as well as with the Laender, on a 'law to search and select a location for a permanent disposal site for heat-generating radioactive waste products and to change other laws', in brief a location selection act also called StandAG. The law was received with animated approval from the ranks of the parties - with the exception of the (left-wing) party Die Linke. This praise is a tad bewildering, since the Bundesumweltministerium (Federal Department of the Environment) named solving the task within a single generation as one of the principles for the StandAG, and it was emphasised again and again in the debates about the StandAG that the problem of permanent disposal must not be shifted to the next generation. Conclusion: - The StandAG leads to a postponement of solving the permanent disposal site issue by a least several generations with its predictable, long-winded selection method. - The decision not to explore Gorleben conclusively could lead to the site being permanently ('wasted' or) 'burned'. - The de-central, interim disposal site Gorleben is likewise 'burned' without having a resilient alternative solution for the glass coquilles that must be taken back. - The people's protest is exponentiated by the number of the potential sites for the StandAG. - The costs for the alternative site search will not be shifted to the producers of the waste that are obliged by law to deliver the waste because of the financial provisions of the constitution. - The third party protection dogma has not been broken up, which will at least lead to delays in the procedure and will have effects on other major projects in the long run. (orig.)

  15. Smart Grid Integration Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Troxell, Wade [Colorado State Univ., Fort Collins, CO (United States)

    2011-12-22

    The initial federal funding for the Colorado State University Smart Grid Integration Laboratory is through a Congressionally Directed Project (CDP), DE-OE0000070 Smart Grid Integration Laboratory. The original program requested in three one-year increments for staff acquisition, curriculum development, and instrumentation all which will benefit the Laboratory. This report focuses on the initial phase of staff acquisition which was directed and administered by DOE NETL/ West Virginia under Project Officer Tom George. Using this CDP funding, we have developed the leadership and intellectual capacity for the SGIC. This was accomplished by investing (hiring) a core team of Smart Grid Systems engineering faculty focused on education, research, and innovation of a secure and smart grid infrastructure. The Smart Grid Integration Laboratory will be housed with the separately funded Integrid Laboratory as part of CSU's overall Smart Grid Integration Center (SGIC). The period of performance of this grant was 10/1/2009 to 9/30/2011 which included one no cost extension due to time delays in faculty hiring. The Smart Grid Integration Laboratory's focus is to build foundations to help graduate and undergraduates acquire systems engineering knowledge; conduct innovative research; and team externally with grid smart organizations. Using the results of the separately funded Smart Grid Workforce Education Workshop (May 2009) sponsored by the City of Fort Collins, Northern Colorado Clean Energy Cluster, Colorado State University Continuing Education, Spirae, and Siemens has been used to guide the hiring of faculty, program curriculum and education plan. This project develops faculty leaders with the intellectual capacity to inspire its students to become leaders that substantially contribute to the development and maintenance of Smart Grid infrastructure through topics such as: (1) Distributed energy systems modeling and control; (2) Energy and power conversion; (3

  16. An Undergraduate Summer Research Program Through A University-Community College Partnership: Design and Results

    Science.gov (United States)

    Hood, Carol E.; Hood, Michael; Woodney, Laura

    2016-06-01

    We present a model for an undergraduate summer research program in astronomy targeted at 2-year and 4-year students and the short-term success of student participants. California State University San Bernardino (CSUSB) is Hispanic Serving Institution (HSI) serving 16,000 students, with no dominant ethnic or racial majority. Most (80%) CSUSB students are first-generation college students, and many of the students - both minority and “majority” - are economically disadvantaged and cannot afford to take on research projects without compensation. Approximately 60 percent of our students transfer from two year colleges, and all of the local community colleges are also officially designated as minority serving institutions. Mt. San Antonio College (Mt. SAC) is the largest single-campus community college in the state of California. It serves a student population of approximately 60,000 students (~35,000 full-time equivalent), also with no dominant ethnic or racial majority. Mt. SAC is currently 5th in the state in transfer ranking into the CSU system.In an effort to involve students in research as early as possible, we selected 2 students from each campus to participate in a summer research program. This program taught students observational techniques, data reduction and analysis skills, and then allowed them to work on more complex faculty astronomical research projects. These students were not selected based on their grades, or specific courses completed, simply based on their essays expressing their interests in astronomy. Students were only required to have already completed at least 1 physics or astronomy class and typically would be classified as freshman or sophomores. This program ran for 2 summers, before funding ran out. By the end of each summer, students were able to run the state-of-the-art campus observatory, and many chose to continue working on their research projects into the school year. To date, 3 students were selected for further summer research

  17. Applications and Improvement of a Coupled, Global and Cloud-Resolving Modeling System

    Science.gov (United States)

    Tao, W.-K.; Chern, J.; Atlas, R.

    2005-01-01

    Recently Grabowski (2001) and Khairoutdinov and Randall (2001) have proposed the use of 2D CFWs as a "super parameterization" [or multi-scale modeling framework (MMF)] to represent cloud processes within atmospheric general circulation models (GCMs). In the MMF, a fine-resolution 2D CRM takes the place of the single-column parameterization used in conventional GCMs. A prototype Goddard MMF based on the 2D Goddard Cumulus Ensemble (GCE) model and the Goddard finite volume general circulation model (fvGCM) is now being developed. The prototype includes the fvGCM run at 2.50 x 20 horizontal resolution with 32 vertical layers from the surface to 1 mb and the 2D (x-z) GCE using 64 horizontal and 32 vertical grid points with 4 km horizontal resolution and a cyclic lateral boundary. The time step for the 2D GCE would be 15 seconds, and the fvGCM-GCE coupling frequency would be 30 minutes (i.e. the fvGCM physical time step). We have successfully developed an fvGCM-GCE coupler for this prototype. Because the vertical coordinate of the fvGCM (a terrain-following floating Lagrangian coordinate) is different from that of the GCE (a z coordinate), vertical interpolations between the two coordinates are needed in the coupler. In interpolating fields from the GCE to fvGCM, we use an existing fvGCM finite- volume piecewise parabolic mapping (PPM) algorithm, which conserves the mass, momentum, and total energy. A new finite-volume PPM algorithm, which conserves the mass, momentum and moist static energy in the z coordinate, is being developed for interpolating fields from the fvGCM to the GCE. In the meeting, we will discuss the major differences between the two MMFs (i.e., the CSU MMF and the Goddard MMF). We will also present performance and critical issues related to the MMFs. In addition, we will present multi-dimensional cloud datasets (i.e., a cloud data library) generated by the Goddard MMF that will be provided to the global modeling community to help improve the

  18. Advanced Natural Gas Reciprocating Engine(s)

    Energy Technology Data Exchange (ETDEWEB)

    Kwok, Doris; Boucher, Cheryl

    2009-09-30

    Energy independence and fuel savings are hallmarks of the nation’s energy strategy. The advancement of natural gas reciprocating engine power generation technology is critical to the nation’s future. A new engine platform that meets the efficiency, emissions, fuel flexibility, cost and reliability/maintainability targets will enable American manufacturers to have highly competitive products that provide substantial environmental and economic benefits in the US and in international markets. Along with Cummins and Waukesha, Caterpillar participated in a multiyear cooperative agreement with the Department of Energy to create a 50% efficiency natural gas powered reciprocating engine system with a 95% reduction in NOx emissions by the year 2013. This platform developed under this agreement will be a significant contributor to the US energy strategy and will enable gas engine technology to remain a highly competitive choice, meeting customer cost of electricity targets, and regulatory environmental standard. Engine development under the Advanced Reciprocating Engine System (ARES) program was divided into phases, with the ultimate goal being approached in a series of incremental steps. This incremental approach would promote the commercialization of ARES technologies as soon as they emerged from development and would provide a technical and commercial foundation of later-developing technologies. Demonstrations of the Phase I and Phase II technology were completed in 2004 and 2008, respectively. Program tasks in Phase III included component and system development and testing from 2009-2012. Two advanced ignition technology evaluations were investigated under the ARES program: laser ignition and distributed ignition (DIGN). In collaboration with Colorado State University (CSU), a laser ignition system was developed to provide ignition at lean burn and high boost conditions. Much work has been performed in Caterpillar’s DIGN program under the ARES program. This work

  19. New Technique for Barium Daughter Ion Identification in a Liquid Xe-136 Double Beta Decay Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Fairbank, William [Colorado State Univ., Fort Collins, CO (United States)

    2016-06-08

    This work addresses long-standing issues of fundamental interest in elementary particle physics. The most important outcome of this work is a new limit on neutrinoless double beta decay. This is an extremely rare and long-sought-after type of radioactive decay. If discovered, it would require changes in the standard model of the elementary constituents of matter, and would prove that neutrinos and antineutrinos are the same, a revolutionary concept in particle physics. Neutrinos are major components of the matter in the universe that are so small and so weakly interacting with other matter that their masses have not yet been discovered. A discovery of neutrinoless double beta decay could help determine the neutrino masses. An important outcome of the work on this project was the Colorado State University role in operating the EXO-200 neutrinoless double beta decay experiment and in analysis of the data from this experiment. One type of double beta decay of the isotope 136Xe, the two-neutrino variety, was discovered in this work. Although the other type of double beta decay, the neutrinoless variety, was not yet discovered in this work, a world’s best sensitivity of 1.9x1025 year half-life was obtained. This result rules out a previous claim of a positive result in a different isotope. This work also establishes that the masses of the neutrinos are less than one millionth of that of electrons. A unique EXO-200 analysis, in which the CSU group had a leading role, has established for the first time ever in a liquid noble gas the fraction of daughter atoms from alpha and beta decay that are ionized. This result has important impact on other pending studies, including nucleon decay and barium tagging. Novel additional discoveries include multiphoton ionization of liquid xenon with UV pulsed lasers, which may find application in calibration of future noble liquid detectors, and studies of association and dissociation reactions of Ba

  20. Submarine Landslides at Santa Catalina Island, California

    Science.gov (United States)

    Legg, M. R.; Francis, R. D.

    2011-12-01

    Santa Catalina Island is an active tectonic block of volcanic and metamorphic rocks originally exposed during middle Miocene transtension along the evolving Pacific-North America transform plate boundary. Post-Miocene transpression created the existing large pop-up structure along the major strike-slip restraining bend of the Catalina fault that forms the southwest flank of the uplift. Prominent submerged marine terraces apparent in high-resolution bathymetric maps interrupt the steep submarine slopes in the upper ~400 meters subsea depths. Steep subaerial slopes of the island are covered by Quaternary landslides, especially at the sea cliffs and in the blueschist metamorphic rocks. The submarine slopes also show numerous landslides that range in area from a few hectares to more than three sq-km (300 hectares). Three or more landslides of recent origin exist between the nearshore and first submerged terrace along the north-facing shelf of the island's West End. One of these slides occurred during September 2005 when divers observed a remarkable change in the seafloor configuration after previous dives in the area. Near a sunken yacht at about 45-ft depth where the bottom had sloped gently into deeper water, a "sinkhole" had formed that dropped steeply to 100-ft or greater depths. Some bubbling sand was observed in the shallow water areas that may be related to the landslide process. High-resolution multibeam bathymetry acquired in 2008 by CSU Monterey Bay show this "fresh" slide and at least two other slides of varying age along the West End. The slides are each roughly 2 hectares in area and their debris aprons are spread across the first terrace at about 85-m water depth that is likely associated with the Last Glacial Maximum sealevel lowstand. Larger submarine slides exist along the steep Catalina and Catalina Ridge escarpments along the southwest flank of the island platform. A prominent slide block, exceeding 3 sq-km in area, appears to have slipped more than

  1. Trabalho do enfermeiro no Centro de Material e seu lugar no processo de cuidar pela enfermagem Trabajo del enfermero en el centro de material y su lugar en el proceso de cuidar de la enfermería The nurse's work at a hospital supply center and his/her place in the care for nursing work

    Directory of Open Access Journals (Sweden)

    Silvia Ricci Tonelli Bartolomei

    2006-09-01

    ífico en el CME que por el administrativo.This is a study on nurses' work at central supply units (CSUs with the aim of analyzing his/her social reality and transforming role in the caring process in health and nursing. It's a strategic research, with speech analysis of CSU nurses. Results show that their main activity is management, in a structured process that confirms the traditional nursing practice, having as object the coordination of medical-hospital material processing used for care. Their work is characterized by indirect care, and is instrumental not only for nurses' work, but for the work of other professionals as well. As a result, it not identified as specific nursing care, nor as care provided by the nurse. Its transforming potential upon relations and new production modes of care in health, and by the nurse, will occur first through his/her competence in the specific knowledge about CSUs than through his/her administrative skills.

  2. Changing Climates @ Colorado State: 100 (Multidisciplinary) Views of Climate Change

    Science.gov (United States)

    Campbell, S.; Calderazzo, J.; Changing Climates, Cmmap Education; Diversity Team

    2011-12-01

    We would like to talk about a multidisciplinary education and outreach program we co-direct at Colorado State University, with support from an NSF-funded STC, CMMAP, the Center for Multiscale Modeling of Atmospheric Processes. We are working to raise public literacy about climate change by providing information that is high quality, up to date, thoroughly multidisciplinary, and easy for non-specialists to understand. Our primary audiences are college-level students, their teachers, and the general public. Our motto is Climate Change is Everybody's Business. To encourage and help our faculty infuse climate-change content into their courses, we have organized some 115 talks given by as many different speakers-speakers drawn from 28 academic departments, all 8 colleges at CSU, and numerous other entities from campus, the community, and farther afield. We began with a faculty-teaching-faculty series and then broadened our attentions to the whole campus and surrounding community. Some talks have been for narrowly focused audiences such as extension agents who work on energy, but most are for more eclectic groups of students, staff, faculty, and citizens. We count heads at most events, and our current total is roughly 6,000. We have created a website (http://changingclimates.colostate.edu) that includes videotapes of many of these talks, short videos we have created, and annotated sources that we judge to be accurate, interesting, clearly written, and aimed at non-specialists, including books, articles and essays, websites, and a few items specifically for college teachers (such as syllabi). Pages of the website focus on such topics as how the climate works / how it changes; what's happening / what might happen; natural ecosystems; agriculture; impacts on people; responses from ethics, art, literature; communication; daily life; policy; energy; and-pulling all the pieces together-the big picture. We have begun working on a new series of very short videos that can be

  3. 阿斯旺高坝水库的野外调查与分析

    Institute of Scientific and Technical Information of China (English)

    M·埃尔·莫阿塔塞姆; 李天扶; 向世武

    1994-01-01

    阿斯旺高坝管理局(HADA)和阿斯旺高坝副作用研究所(HADSERI)每年都对阿斯旺高坝上游进行水库泥沙调查.以确定泥沙淤积的位置和范围。这些调查的主要目的是不断修正水库有效库容地区内水位——库容关系,这是水资源规划与分配的基础。这是一件很重要的事,因为左干旱地区对可能供水量哪怕有一点点低估,也会给一些用户带来灾难性的后果。除进行每年一度的水库调查外,HADSERI有时还对水库的其它方面进行专门性研究。近期的努力方向是建立水库的数学模型.设计并实现这一模型的数据采集程序。1990年2、3月间已着手进行数据采集程年的第一阶段工作。整个工作是与HADA和科罗拉多州立大学(CSU)合作.左HADA的科研考察船R/V SADD EL—AALI Ⅰ号上进行的。本文介绍该项工作的一些初步成果。该项研究工作包括:·泥沙采样与水深测量新设备的试验;·水位连续记录仪安装地点的选择;·左岸风沙入库范围的初步调查;·靠近库首处径流量与输沙量驯量位置的选择。水位记录仪将提供连续的回水断面以校:拉模型的水力学部分。这些仪器最终将实现自动化,以遥测方法将数据直接送往阿斯旺和开罗。初步成果表明,风沙的绝大部分是在距坝上游750km的栋古拉(Dongola)测流站与库首之间入库的。或者需要估算这些风沙量.或者应该将该测流站迁到距库首更近的地方。

  4. Pollution Status of Trace Metals in Groundwater Due to Industrail Activities in and Around Dhaka Export Processing Zone, Bangladesh

    Directory of Open Access Journals (Sweden)

    GOLAM AHMED

    2012-06-01

    .69, Ga-U (0.77, Sr-Pb (0.85 and Ba-Ag (0.99 in the grounwater samples inside DEPZ, and for Cu-Cs (0.78, Cu-Ba (0.73, Pb-Cu (0.69, Cu-U (0.70, Cr-Cd (0.71, Ni-Cu (0.83, Ni-Se (0.70, Li-Se (0.72, Li-Cd (0.84, Cu-V (0.78, V-Ga (0.82, Sr-V (0.68, Ba-V (0.67, Zn-Ga (0.75, Zn-Ag (0.69, Se-Ga (0.67, As-Rb (0.84, Se-Ba (0.67, Sr-Ba (0.79, Sr-Pb (0.71, Cs-U (0.83 and Pb-Ba (0.98 in the groundwater around DEPZ at 0.05 to 0.01 level. Considering the elemental load, it was assumed that the groundwater of DTWs inside DEPZ are still isolated from potential contaminated sources, whereas groundwater of STWs around DEPZ seemed to be gradually affected by the sources of these toxic trace metal.

  5. 将BIM纳入施工管理教育%IntegratIng BIM Into ConstruCtIon ManageMent eduCatIon

    Institute of Scientific and Technical Information of China (English)

    卡洛琳娜·M·克莱温格尔; 麦哈迈德·奥兹别克; 斯考特·格里克; 达勒·波尔特

    2012-01-01

      BIM作为工具与方法的作用在教育界和工业界中并没有得到充分的理解。行业领导者认为BIM需要新型的工作程序,他们渴望将BIM应用到对其未来员工的教育中。我们计划在试点项目中加入一门将BIM作为一种软件、以其建模为主要内容的课程,目前我们着重开发“BIM教学单元”,以展示BIM程序在施工管理实践方面所发挥的作用。这些正在与行业合作开发的单元,强调了在不改变施工基本原则的情况下,如何使BIM的应用达到最佳并提高核心竞争力。经过持续不断的研究和试验性实施,作者试图理解并适应施工管理教育迫在眉睫的转变,从而改进课程,通过应用BIM促进更好的理解和学习。%  Construction education needs to embrace the opportunities and overcome the chal enges presented by Building Information Modeling (BIM) to remain current and relevant. Although a growing number of university architecture, engineering and construction (AEC) programs have begun to of er courses that include BIM content, few programs have strategies in place to ful y integrate BIM across curriculum. This paper presents Colorado State Universityˇs (CSU) Construction Management Departmentˇs approach to promote BIM-enabled learning. Fundamental to this ef ort is balancing student and industry desires and faculty domain expertise, while leveraging industry support and guidance. This paper presents the authorsˇdevelopment of exploratory teaching modules and preliminary research findings to better understand and evaluate the contribution of BIM to studentsˇeducational experiences.   The role of BIM as both tool and method in education and industry is not yet ful y understood. Industry leaders understand that BIM requires new working processes and are eager to leverage BIM in the education of their future employees. Our pilot program plans to include a course that focuses on the modeling aspects

  6. Advanced Natural Gas Reciprocating Engine(s)

    Energy Technology Data Exchange (ETDEWEB)

    Kwok, Doris; Boucher, Cheryl

    2009-09-30

    Energy independence and fuel savings are hallmarks of the nation’s energy strategy. The advancement of natural gas reciprocating engine power generation technology is critical to the nation’s future. A new engine platform that meets the efficiency, emissions, fuel flexibility, cost and reliability/maintainability targets will enable American manufacturers to have highly competitive products that provide substantial environmental and economic benefits in the US and in international markets. Along with Cummins and Waukesha, Caterpillar participated in a multiyear cooperative agreement with the Department of Energy to create a 50% efficiency natural gas powered reciprocating engine system with a 95% reduction in NOx emissions by the year 2013. This platform developed under this agreement will be a significant contributor to the US energy strategy and will enable gas engine technology to remain a highly competitive choice, meeting customer cost of electricity targets, and regulatory environmental standard. Engine development under the Advanced Reciprocating Engine System (ARES) program was divided into phases, with the ultimate goal being approached in a series of incremental steps. This incremental approach would promote the commercialization of ARES technologies as soon as they emerged from development and would provide a technical and commercial foundation of later-developing technologies. Demonstrations of the Phase I and Phase II technology were completed in 2004 and 2008, respectively. Program tasks in Phase III included component and system development and testing from 2009-2012. Two advanced ignition technology evaluations were investigated under the ARES program: laser ignition and distributed ignition (DIGN). In collaboration with Colorado State University (CSU), a laser ignition system was developed to provide ignition at lean burn and high boost conditions. Much work has been performed in Caterpillar’s DIGN program under the ARES program. This work

  7. IMPROVEMENT TO PIPELINE COMPRESSOR ENGINE RELIABILITY THROUGH RETROFIT MICRO-PILOT IGNITION SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Ted Bestor

    2004-06-01

    ;'Hg lower and the minimum pilot quantity that the engine would operate on was roughly cut in half. (3) A successful concept demonstration of engine lube oil pilot injection was performed where the minimum operational boost was reduced by another 5''Hg to a boost level of 3''Hg; this is, depending on altitude, in the range of boost levels of many blower and piston scavenged low BMEP engines. (4) Micropilot ignition compares very favorably to other ignitions systems. The performance of micropilot ignition with mechanical gas admission valves is very similar to the performance of precombustion chamber ignition with high pressure fuel injection. Compared to spark ignition with mechanical gas admission valves the lean limit of operation is extended by about 5''Hg. These laboratory results will be enhanced, demonstrated and commercialized by others, with management and support from CSU, during Phase III of the Micropilot Ignition program.

  8. New Technique for Barium Daughter Ion Identification in a Liquid Xe-136 Double Beta Decay Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Fairbank, William [Colorado State Univ., Fort Collins, CO (United States)

    2016-06-08

    This work addresses long-standing issues of fundamental interest in elementary particle physics. The most important outcome of this work is a new limit on neutrinoless double beta decay. This is an extremely rare and long sought after type of radioactive decay. If discovered, it would require changes in the standard model of the elementary constituents of matter, and would prove that neutrinos and antineutrinos are the same, a revolutionary concept in particle physics. Neutrinos are major components of the matter in the universe that are so small and so weakly interacting with other matter that their masses have not yet been discovered. A discovery of neutrinoless double beta decay could help determine the neutrino masses. An important outcome of the work on this project was the Colorado State University role in operating the EXO-200 neutrinoless double beta decay experiment and in analysis of the data from this experiment. One type of double beta decay of the isotope 136Xe, the two-neutrino variety, was discovered in this work. Although the other type of double beta decay, the neutrinoless variety, was not yet discovered in this work, a world’s best sensitivity of 1.9x1025 year half-life was obtained. This result rules out a previous claim of a positive result in a different isotope. This work also establishes that the masses of the neutrinos, are less than one millionth of that of electrons. A unique EXO-200 analysis, in which the CSU group had a leading role, has established for the first time ever in a liquid noble gas the fraction of daughter atoms from alpha and beta decay that are ionized. This result has important impact on other pending studies, including nucleon decay and barium tagging. Novel additional discoveries include multiphoton ionization of liquid xenon with UV pulsed lasers, which may find application in calibration of future noble liquid detectors, and studies of association and dissociation reactions of Ba

  9. La compatibilidad vegetativa: un método para diferenciar razas fisiológicas y formas especiales de Fusarium oxysporum Schlecht.

    Directory of Open Access Journals (Sweden)

    Posada Buitrago Martha Lucia

    1994-12-01

    ;">Díanthi raza 4 Colombia y el CSCSU (de baja patogenicidad formaron el VCG2. Los aislamientos extranjeros de F. oxysporum f. sp. díantí raza 1 y raza 8 Italia, el C14CSU y el colombiano 71 conformaron, cada uno, su propio grupo.

  10. Actividad clínica en la consulta médica a demanda de un Centro Penitenciario frente a la de un Centro de Salud Comparisons between clinical practice consultation in a prison and in community health centres: differences and repercussions

    Directory of Open Access Journals (Sweden)

    C. Chérrez

    2007-02-01

    Full Text Available Objetivos: Describir y cuantificar la actividad clínica en las consultas de demanda de un Centro Penitenciario (CP para valorar las posibles diferencias respecto a un Centro de Salud (CS. Identificar los posibles requerimientos de formación específica ante eventuales traslados de profesionales entre uno y otro medio, resultantes de una supuesta integración de la Sanidad Penitenciaria (SP en el conjunto del Sistema Público de Salud (SPS. Método: Estudio descriptivo transversal. Se aplica en tres equipos de Atención Primaria (AP: un Centro de Salud Urbano de alta carga asistencial (CSU, un Centro de Salud Rural de baja carga asistencial (CSR y un CP provincial -no tipo macro cárcel-. Muestreo aleatorio secuencial que incluye toda la actividad médica generada en la consulta de demanda. Se excluye toda la actividad programada por el profesional sanitario y las consultas administrativas. Se realiza un intento de reconocimiento de consultas conflictivas para el profesional. Las comparaciones se realizan mediante el test estadístico de Contraste de Diferencia de Proporciones. Resultados: En el CP se halla significación estadística (SE de mayor actividad clínica en las áreas de salud mental, toxicomanías, manejo de infección VIH-VHC y de problemas específicos de AP (integración biopsicosocial prioritaria en su tratamiento. En ambos CS hay SE de mayor actividad en el conjunto del área de Medicina Interna (MI y de Geriatría (G. En el medio penitenciario hay SE de mayor conflictividad en la consulta. Conclusiones: En un futuro contexto de integración de derecho de la SP, puede ser necesaria formación en salud mental, particularmente en trastornos adictivos, y en manejo de infección VIH-VHC para ejercer en un CP. Puede ser necesaria formación en el conjunto de Medicina Interna, particularmente en Geriatría, de médicos de CP para que se trasladen a CS. La significación obtenida, en la asistencia sanitaria de una prisión, de la AP

  11. Use of ARM observations and numerical models to determine radiative and latent heating profiles of mesoscale convective systems for general circulation models

    Energy Technology Data Exchange (ETDEWEB)

    Tao, Wei-Kuo; Houze, Robert, A., Jr.; Zeng, Xiping

    2013-03-14

    were compared with three reanalyses (MERRA, ERA-Interim and CFSR). Although the MMF tends to produce a higher precipitation rate over some topical regions, it actually well captures the variations in the zonal and meridional means. Among the three reanalyses, ERA-Interim seems to have values close to those of the satellite retrievals especially for GPCP. It is interesting to note that the MMF obtained the best results in the rain forest of Africa even better than those of CFSR and ERA-Interim, when compared to CMORPH. MERRA fails to capture the precipitation in this region. We are now collaborating with Steve Rutledge (CSU) to validate the model results for AMMA 6. MC3E and the diurnal variation of precipitation processes The Midlatitude Continental Convective Clouds Experiment (MC3E) was a joint field campaign between the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility and the NASA Global Precipitation Measurement (GPM) mission Ground Validation (GV) program. It took place in central Oklahoma during the period April 22 _ June 6, 2011. Some of its major objectives involve the use of CRMs in precipitation science such as: (1) testing the fidelity of CRM simulations via intensive statistical comparisons between simulated and observed cloud properties and latent heating fields for a variety of case types, (2) establishing the limits of CRM space-time integration capabilities for quantitative precipitation estimates, and (3) supporting the development and refinement of physically-based GMI, DPR, and DPR-GMI combined retrieval algorithms using ground-based GPM GV Ku-Ka band radar and CRM simulations. The NASA unified WRF model (nu-WRF) was used for real time forecasts during the field campaign, and ten precipitation events were selected for post mission simulations. These events include well-organized squall lines, scattered storms and quasi-linear storms. A paper focused on the diurnal variation of precipitation will be

  12. PREFACE: 11th IAEA Technical Meeting on H-mode Physics and Transport Barriers

    Science.gov (United States)

    Takizuka, Tomonori

    2008-07-01

    Takizuka (Japan Atomic Energy Agency, Japan: Chair) R J Groebner (General Atomics, USA) T S Hahm (Princeton Plasma Physics Laboratory, USA) A E Hubbard (MIT Plasma Science and Fusion Center, USA) K Ida (National Institute for Fusion Science, Japan) S V Lebedev (Ioffe Institute, Russia) G Saibene (EFDA CSU Garching, Germany) W Suttrop (Max-Plank-Institut für Plasmaphysik, Germany) Additional information about this meeting (H-mode-TM-11) is available in its homepage http://www-jt60.naka.jaea.go.jp/h-mode-tm-11/. List of Participants N Aiba (Japan Atomic Energy Agency, Japan) T Akiyama (National Institute for Fusion Science, Japan) N Asakura (Japan Atomic Energy Agency, Japan) L G Askinazi (Ioffe Institute, Russia) M N A Beurskens (EURATOM/UKAEA Fusion Association, UK) J D Callen (University of Wisconsin, USA) T Cho (University of Tsukuba, Japan) P C DeVries (EURATOM/UKAEA Fusion Association, UK) X T Ding (Southwestern Institute of Physics, China) E J Doyle (University of California, Los Angels, USA) A Fukuyama (Kyoto University, Japan) P Gohil (General Atomics, USA) R J Groebner (General Atomics, USA) T S Hahm (Princeton Plasma Physics Laboratory, USA) N Hayashi (Japan Atomic Energy Agency, Japan) Y Higashiyama (Nagoya University, Japan) Y Higashizono (University of Tsukuba, Japan) M Hirata (University of Tsukuba, Japan) G T Hoang (Association Euratom-CEA sur la Fusion Controle, France) G M D Hogeweij (FOM-Institute for Plasma Physics Rijnhuizen, The Netherlands) M Honda (Japan Atomic Energy Agency, Japan) L D Horton (Max-Plank-Institut für Plasmaphysik, Germany) W A Houlberg (ITER Organization) A E Hubbard (MIT Plasma Science and Fusion Center, USA) J W Hughes (MIT Plasma Science and Fusion Center, USA) M Ichimura (University of Tsukuba, Japan) K Ida (National Institute for Fusion Science, Japan) T Ido (National Institute for Fusion Science, Japan) T Imai (University of Tsukuba, Japan) F Imbeaux (Association Euratom-CEA sur la Fusion Controle, France) A Itakura