CRC-cards for Product Modelling

DEFF Research Database (Denmark)

Hvam, Lars; Riis, Jesper; Hansen, Benjamin Loer

2003-01-01

, transportation, service and decommissioning. A main challenge when building product models is to collect and document the product related data, information and knowledge in a structured way. CRC cards are index cards (or computerized versions of these) which are used to record proposed classes, the behavior......This paper describes the CRC (class, responsibility, collaboration) modelling process for building product models. A product model is normally represented in an IT system which contains data, information and knowledge on industrial products and their life cycle properties e.g. manufacturing...... of the classes, their responsibilities, and their relationship to other classes (collaboration). CRC modelling gives an effective, low-tech method for domain-experts, programmers and users to work closely together to identify, structure, understand and document a product model. CRC cards were originally...

Upconversion studies in rare earth ions-doped lanthanide materials

Indian Academy of Sciences (India)

2014-02-08

Feb 8, 2014 ... studied samples in order to get the visible upconversion emission on 976 nm excitation. References. [1] F Azuel, Chem. Rev. 104, 139 (2004). [2] W M Yen, S Shionoya and H Yamamoto (eds), Practical applications of phosphors (CRC. Press, Taylor and Francis Group, 2006). [3] F Wang and X Liu, Chem.

From Taylor series to Taylor models

International Nuclear Information System (INIS)

Berz, Martin

1997-01-01

An overview of the background of Taylor series methods and the utilization of the differential algebraic structure is given, and various associated techniques are reviewed. The conventional Taylor methods are extended to allow for a rigorous treatment of bounds for the remainder of the expansion in a similarly universal way. Utilizing differential algebraic and functional analytic arguments on the set of Taylor models, arbitrary order integrators with rigorous remainder treatment are developed. The integrators can meet pre-specified accuracy requirements in a mathematically strict way, and are a stepping stone towards fully rigorous estimates of stability of repetitive systems

From Taylor series to Taylor models

International Nuclear Information System (INIS)

Berz, M.

1997-01-01

An overview of the background of Taylor series methods and the utilization of the differential algebraic structure is given, and various associated techniques are reviewed. The conventional Taylor methods are extended to allow for a rigorous treatment of bounds for the remainder of the expansion in a similarly universal way. Utilizing differential algebraic and functional analytic arguments on the set of Taylor models, arbitrary order integrators with rigorous remainder treatment are developed. The integrators can meet pre-specified accuracy requirements in a mathematically strict way, and are a stepping stone towards fully rigorous estimates of stability of repetitive systems. copyright 1997 American Institute of Physics

Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing.

Science.gov (United States)

Chubb, Daniel; Broderick, Peter; Frampton, Matthew; Kinnersley, Ben; Sherborne, Amy; Penegar, Steven; Lloyd, Amy; Ma, Yussanne P; Dobbins, Sara E; Houlston, Richard S

2015-02-10

Knowledge of the contribution of high-penetrance susceptibility to familial colorectal cancer (CRC) is relevant to the counseling, treatment, and surveillance of CRC patients and families. To quantify the impact of germline mutation to familial CRC, we sequenced the mismatch repair genes (MMR) APC, MUTYH, and SMAD4/BMPR1A in 626 early-onset familial CRC cases ascertained through a population-based United Kingdom national registry. In addition, we evaluated the contribution of mutations in the exonuclease domain (exodom) of POLE and POLD1 genes that have recently been reported to confer CRC risk. Overall mutations (pathogenic, likely pathogenic) in MMR genes make the highest contribution to familial CRC (10.9%). Mutations in the other established CRC genes account for 3.3% of cases. POLE/POLD1 exodom mutations were identified in three patients with family histories consistent with dominant transmission of CRC. Collectively, mutations in the known genes account for 14.2% of familial CRC (89 of 626 cases; 95% CI = 11.5, 17.2). A genetic diagnosis is feasible in a high proportion of familial CRC. Mainstreaming such analysis in clinical practice should enable the medical management of patients and their families to be optimized. Findings suggest CRC screening of POLE and POLD1 mutation carriers should be comparable to that afforded to those at risk of HNPCC. Although the risk of CRC associated with unexplained familial CRC is in general moderate, in some families the risk is substantive and likely to be the consequence of unidentified genes, as exemplified by POLE and POLD1. Our findings have utility in the design of genetic analyses to identify such novel CRC risk genes. © 2015 by American Society of Clinical Oncology.

Upregulated STAT3 and RhoA signaling in colorectal cancer (CRC) regulate the invasion and migration of CRC cells.

Science.gov (United States)

Zhang, G-Y; Yang, W-H; Chen, Z

2016-05-01

We aimed to reveal the expression and activation of signal transducers and activators of transcription 3 (STAT3) and RhoA/Rho-associated coiled-coil forming kinase 1 (ROCK1) signaling in CRC tissues, and to investigate the regulatory role of STAT3 and RhoA signaling in the invasion and migration of colorectal cancer cells. We examined the expression of STAT3, RhoA and ROCK1 in CRC tissues with real-time PCR and Western blotting methods. And then we examined the interaction between STAT3 and RhoA/ROCK1 signaling in CRC HT-29 cells with gain-of-function and loss-of-function strategies. In addition, we determined the regulation by STAT3 and RhoA/ROCK1 on the invasion and migration of CRC HT-29 cells. Our study demonstrated a significant upregulation of RhoA and ROCK1 expression and STAT3-Y705 phosphorylation in 32 CRC specimens, compared to the 17 normal CRC tissues. Further study demonstrated there was a coordination between STAT3 and RhoA/Rock signaling in the HT-29 cells. Moreover, STAT3 knockdown or RhoA knockdown significantly repressed the migration and invasion in HT-29 cells and vice versa. STAT3 and RhoA signaling regulate the invasion and migration of CRC cells, implying the orchestrated and oncogenic roles of STAT3 and RhoA/ROCK1 signaling in CRC.

Tape Storage and CRC Protection

CERN Document Server

Ha, Karel

2014-01-01

Over 100 Petabytes of data is stored on several kind of physical support, namely disks and tapes. Data on any physical support or traveling on a data link (network, fibre channel...) can be subject to silent data corruption. A possible improvement is introducing end-to-end data integrity from the filesystem down to the tape layer. For the tape back-end it can be done by using Logical Block Protection, which computes and compares CRC checksum of every single block of data. During my work, I improved on-the-fly CRC calculation for the tape storage system, which was achieved by introducing a multithreaded implementation - a technique applicable to arbitrary CRC algorithm. Finally, I per...

Book review of “Imaging in Cellular and Tissue Engineering” edited by Y Hanry Yu and Nur Aida Abdul Rahim

OpenAIRE

Brey, Eric Michael

2014-01-01

This article is a review of the book “Imaging in Cellular and Tissue Engineering” (ISBN-13: 978-1439848036, $149.95, 298 Pages, 114 Illustrations) edited by Y Hanry Yu and Nur Aida Abdul Rahim published by the CRC Press (Taylor&Francis) in 2013. The contents of the book and its relevance to tissue engineering and regenerative medicine are discussed in this invited review.

More comprehensive discussion of CRC screening associated with higher screening.

Science.gov (United States)

Mosen, David M; Feldstein, Adrianne C; Perrin, Nancy A; Rosales, A Gabriella; Smith, David H; Liles, Elizabeth G; Schneider, Jennifer L; Meyers, Ronald E; Elston-Lafata, Jennifer

2013-04-01

Examine association of comprehensiveness of colorectal cancer (CRC) screening discussion by primary care physicians (PCPs) with completion of CRC screening. Observational study in Kaiser Permanente Northwest, a group-model health maintenance organization. A total of 883 participants overdue for CRC screening received an automated telephone call (ATC) between April and June 2009 encouraging CRC screening. Between January and March 2010, participants completed a survey on PCPs' discussion of CRC screening and patient beliefs regarding screening. receipt of CRC screening (assessed by electronic medical record [EMR], 9 months after ATC). Primary independent variable: comprehensiveness of CRC screening discussion by PCPs (7-item scale). Secondary independent variables: perceived benefits of screening (4-item scale assessing respondents' agreement with benefits of timely screening) and primary care utilization (EMR; 9 months after ATC). The independent association of variables with CRC screening was assessed with logistic regression. Average scores for comprehensiveness of CRC discussion and perceived benefits were 0.4 (range 0-1) and 4.0 (range 1-5), respectively. A total of 28.2% (n = 249) completed screening, 84% of whom had survey assessments after their screening date. Of screeners, 95.2% completed the fecal immunochemical test. More comprehensive discussion of CRC screening was associated with increased screening (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.03-2.21). Higher perceived benefits (OR = 1.46, 95% CI = 1.13-1.90) and 1 or more PCP visits (OR = 5.82, 95% CI = 3.87-8.74) were also associated with increased screening. More comprehensive discussion of CRC screening was independently associated with increased CRC screening. Primary care utilization was even more strongly associated with CRC screening, irrespective of discussion of CRC screening.

Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance.

Science.gov (United States)

Krzystek-Korpacka, Malgorzata; Diakowska, Dorota; Kapturkiewicz, Bartosz; Bębenek, Marek; Gamian, Andrzej

2013-08-28

Alternate colorectal cancer (CRC) screening and surveillance strategies are needed to pre-select candidates for invasive methods. We compared systemic inflammatory profiles in CRC (n=99), health (n=98), high CRC-risk conditions (n=48) and overt inflammation (n=69) by multiplexed analysis of IL-1β, IL-6, IL-8, FGF-2, G-CSF, GM-CSF, MCP-1, MIP-1α, TNF-α, VEGF-A, and PDGF-B and CEA. Cytokines corresponded with CRC advancement. FGF2, GM-CSF, IL-1β, IL-6, MIP-1α, PDGF-BB, TNF-α, and VEGF-A were higher than in controls already in stage I CRC with FGF2, IL1-β, and MIP-1α higher than in high CRC-risk individuals as well. Cytokine panels devised to differentiate early CRC from controls, adenomas, or inflammatory bowel disease patients (IBD) had good accuracy but only IBD panel had promising specificity at 95% sensitivity. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Fault isolation through no-overhead link level CRC

Science.gov (United States)

Chen, Dong; Coteus, Paul W.; Gara, Alan G.

2007-04-24

A fault isolation technique for checking the accuracy of data packets transmitted between nodes of a parallel processor. An independent crc is kept of all data sent from one processor to another, and received from one processor to another. At the end of each checkpoint, the crcs are compared. If they do not match, there was an error. The crcs may be cleared and restarted at each checkpoint. In the preferred embodiment, the basic functionality is to calculate a CRC of all packet data that has been successfully transmitted across a given link. This CRC is done on both ends of the link, thereby allowing an independent check on all data believed to have been correctly transmitted. Preferably, all links have this CRC coverage, and the CRC used in this link level check is different from that used in the packet transfer protocol. This independent check, if successfully passed, virtually eliminates the possibility that any data errors were missed during the previous transfer period.

Advances in CRC Prevention: Screening and Surveillance.

Science.gov (United States)

Dekker, Evelien; Rex, Douglas K

2018-05-01

Colorectal cancer (CRC) is among the most commonly diagnosed cancers and causes of death from cancer across the world. CRC can, however, be detected in asymptomatic patients at a curable stage, and several studies have shown lower mortality among patients who undergo screening compared with those who do not. Using colonoscopy in CRC screening also results in the detection of precancerous polyps that can be directly removed during the procedure, thereby reducing the incidence of cancer. In the past decade, convincing evidence has appeared that the effectiveness of colonoscopy as CRC prevention tool is associated with the quality of the procedure. This review aims to provide an up-to-date overview of recent efforts to improve colonoscopy effectiveness by enhancing detection and improving the completeness and safety of resection of colorectal lesions. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

High Rab27A expression indicates favorable prognosis in CRC.

Science.gov (United States)

Shi, Chuanbing; Yang, Xiaojun; Ni, Yijiang; Hou, Ning; Xu, Li; Zhan, Feng; Zhu, Huijun; Xiong, Lin; Chen, Pingsheng

2015-06-13

Rab27A is a peculiar member in Rab family and has been suggested to play essential roles in the development of human cancers. However, the association between Rab27A expression and clinicopathological characteristics of colorectal cancer (CRC) has not been elucidated yet. One-step quantitative real-time polymerase chain reaction (qPCR) test with 18 fresh-frozen CRC samples and immunohistochemistry (IHC) analysis in 112 CRC cases were executed to evaluate the relationship between Rab27A expression and the clinicopathological features of CRC. Cox regression and Kaplan-Meier survival analyses were performed to identify the prognostic factors for 112 CRC patients. The results specified that the expression levels of Rab27A mRNA and protein were significantly higher in CRC tissues than that in matched non-cancerous tissues, in both qPCR test (p = 0.029) and IHC analysis (p = 0.020). The IHC data indicated that the Rab27A protein expression in CRC was statistically correlated with lymph node metastasis (p = 0.022) and TNM stage (p = 0.026). Cox multi-factor analysis and Kaplan-Meier method suggested Rab27A protein expression (p = 0.012) and tumor differentiation (p = 0.004) were significantly associated with the overall survival of CRC patients. The data indicated the differentiate expression of Rab27A in CRC tissues and matched non-cancerous tissues. Rab27A may be used as a valuable prognostic biomarker for CRC patients.

Advances in CRC prevention: screening and surveillance

NARCIS (Netherlands)

Dekker, Evelien; Rex, Douglas K.

2018-01-01

Colorectal cancer (CRC) is amongst the most commonly diagnosed cancers and causes of death from cancer across the world. CRC can, however, be detected in asymptomatic patients at a curable stage, and several studies have shown lower mortality among patients who undergo screening compared to those

Transitions between Taylor vortices and spirals via wavy Taylor vortices and wavy spirals

International Nuclear Information System (INIS)

Hoffmann, Ch; Altmeyer, S; Pinter, A; Luecke, M

2009-01-01

We present numerical simulations of closed wavy Taylor vortices and of helicoidal wavy spirals in the Taylor-Couette system. These wavy structures appearing via a secondary bifurcation out of Taylor vortex flow and out of spiral vortex flow, respectively, mediate transitions between Taylor and spiral vortices and vice versa. Structure, dynamics, stability and bifurcation behaviour are investigated in quantitative detail as a function of Reynolds numbers and wave numbers for counter-rotating as well as corotating cylinders. These results are obtained by solving the Navier-Stokes equations subject to axial periodicity for a radius ratio η=0.5 with a combination of a finite differences method and a Galerkin method.

System applications CRC -Biomass + Coal; Aplicaciones Sistema CRC-Biomasa+Carbon

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-07-01

Main object of Phase I of the project is to analyse the technical-economic feasibility of the combined use of biomass and coal for power generation in the Spanish region of Andalusia, by means of new medium-size independent power plants or using biomass as supplementary fuel in existing large coal power plants, including: -Analysis and classification of biomass and coal resources in the region -Technical-economic study of conventional alternatives using the steam cycle -Analysis of efficiency improvement provided by advanced Rankine-cycle technologies, like the SMR cycle -Analysis of alternatives based on parallel combined cycles using gas turbines, including advanced solutions, like the EAPI and CRC-EAPI systems. -Description and evaluation of different biomass drying systems. -Description and evaluation of the three main biomass gasification systems currently under development: atmospheric direct, atmospheric indirect and pressurized. Main objects of Phase II of the project are to analyse a specific application of the EAPI system to a real cogeneration plant project and to analyse the application of the CRC2 system to a commercial supercritical power plant, including technical-economic study of both applications. (Author)

Polar Coding with CRC-Aided List Decoding

Science.gov (United States)

2015-08-01

TECHNICAL REPORT 2087 August 2015 Polar Coding with CRC-Aided List Decoding David Wasserman Approved...list decoding . RESULTS Our simulation results show that polar coding can produce results very similar to the FEC used in the Digital Video...standard. RECOMMENDATIONS In any application for which the DVB-S2 FEC is considered, polar coding with CRC-aided list decod - ing with N = 65536

Mining, Validation, and Clinical Significance of Colorectal Cancer (CRC)-Associated lncRNAs.

Science.gov (United States)

Sun, Xiangwei; Hu, Yingying; Zhang, Liang; Hu, Changyuan; Guo, Gangqiang; Mao, Chenchen; Xu, Jianfeng; Ye, Sisi; Huang, Guanli; Xue, Xiangyang; Guo, Aizhen; Shen, Xian

2016-01-01

Colorectal cancer (CRC) is one of the deadliest tumours, but its pathogenesis remains unclear. The involvement of differentially expressed long non-coding RNAs (lncRNAs) in CRC tumorigenesis makes them suitable tumour biomarkers. Here, we screened 150 cases of CRC and 85 cases of paracancerous tissues in the GEO database for differentially expressed lncRNAs. The levels of lncRNA candidates in 84 CRC and paracancerous tissue samples were validated by qRT-PCR and their clinical significance was analyzed. We identified 15 lncRNAs with differential expression in CRC tumours; among them, AK098081 was significantly up-regulated, whereas AK025209, BC040303, BC037331, AK026659, and CR749831 were down-regulated in CRC. In a receiver operating characteristic curve analysis, the area under the curve for the six lncRNAs was 0.914. High expression of AK098081 and low expression of BC040303, CR749831, and BC037331 indicated poor CRC differentiation. CRC patients with lymph node metastasis had lower expression of BC037331. In addition, the group with high AK098081 expression presented significantly lower overall survival and disease-free survival rates than the low-expression group, confirming AK098081 as an independent risk factor for CRC patients. In conclusion, we have identified multiple CRC-associated lncRNAs from microarray expression profiles that can serve as novel biomarkers for the diagnosis and prognosis of CRC.

A Novel Least Significant Bit First Processing Parallel CRC Circuit

Directory of Open Access Journals (Sweden)

Xiujie Qu

2013-01-01

Full Text Available In HDLC serial communication protocol, CRC calculation can first process the most or least significant bit of data. Nowadays most CRC calculation is based on the most significant bit (MSB first processing. An algorithm of the least significant bit (LSB first processing parallel CRC is proposed in this paper. Based on the general expression of the least significant bit first processing serial CRC, using state equation method of linear system, we derive a recursive formula by the mathematical deduction. The recursive formula is applicable to any number of bits processed in parallel and any series of generator polynomial. According to the formula, we present the parallel circuit of CRC calculation and implement it with VHDL on FPGA. The results verify the accuracy and effectiveness of this method.

Looking for the Women in Baron and Taylor's (1969) "Educational Administration and the Social Sciences"

Science.gov (United States)

Fuller, Kay

2014-01-01

A search for women in Baron and Taylor's (1969) "Educational administration and the social sciences" [London: The Athlone Press] using feminist poststructural discourse analysis (FPDA) has revealed a changing discourse about gendered educational administration over the course of 50 years. Whilst few women are featured in the text…

Taylor-Made Libraries

Science.gov (United States)

Lonergan, David

2011-01-01

Frederick Winslow Taylor (1856-1915) was an efficiency expert whose concerns were less about avoiding worker fatigue and more about increasing profit margins by any means necessary. Taylor was devoted to finding the One Best Way to carry out a task and then training workers to do that task unvaryingly; attempts by employees to improve their own…

Successful collaboration in healthcare?a guide for physicians, nurses and clinical documentation specialists

OpenAIRE

Larsen, Torben

2010-01-01

Book reviewSuccessful collaboration in healthcare-a guide for physicians, nurses and clinical documentation specialistsColleen Stukenberg New York: CRC Press, Taylor & Francis Group, 2010, pp. 136ISBN 978 1 4389 1292 1This book addresses an important topic, especially for health professionals engaged in integrated care (IC). Also, the book is easy to read with about 120 pages in a fluent language that you feel is based on first hand personal job experiences.Colleen Stukenberg is a certifi...

CRC-113 gene expression signature for predicting prognosis in patients with colorectal cancer.

Science.gov (United States)

Nguyen, Minh Nam; Choi, Tae Gyu; Nguyen, Dinh Truong; Kim, Jin-Hwan; Jo, Yong Hwa; Shahid, Muhammad; Akter, Salima; Aryal, Saurav Nath; Yoo, Ji Youn; Ahn, Yong-Joo; Cho, Kyoung Min; Lee, Ju-Seog; Choe, Wonchae; Kang, Insug; Ha, Joohun; Kim, Sung Soo

2015-10-13

Colorectal cancer (CRC) is the third leading cause of global cancer mortality. Recent studies have proposed several gene signatures to predict CRC prognosis, but none of those have proven reliable for predicting prognosis in clinical practice yet due to poor reproducibility and molecular heterogeneity. Here, we have established a prognostic signature of 113 probe sets (CRC-113) that include potential biomarkers and reflect the biological and clinical characteristics. Robustness and accuracy were significantly validated in external data sets from 19 centers in five countries. In multivariate analysis, CRC-113 gene signature showed a stronger prognostic value for survival and disease recurrence in CRC patients than current clinicopathological risk factors and molecular alterations. We also demonstrated that the CRC-113 gene signature reflected both genetic and epigenetic molecular heterogeneity in CRC patients. Furthermore, incorporation of the CRC-113 gene signature into a clinical context and molecular markers further refined the selection of the CRC patients who might benefit from postoperative chemotherapy. Conclusively, CRC-113 gene signature provides new possibilities for improving prognostic models and personalized therapeutic strategies.

Who believes in the Taylor Principle?

DEFF Research Database (Denmark)

Stadtmann, Georg; Pierdzioch; Rülke

2012-01-01

The Livingston survey data are used to investigate whether economists’ forecasts are consistent with the Taylor principle. Consistency with the Taylor principle is strong for academics and Federal Reserve economists, and less strong for private-sector economists.......The Livingston survey data are used to investigate whether economists’ forecasts are consistent with the Taylor principle. Consistency with the Taylor principle is strong for academics and Federal Reserve economists, and less strong for private-sector economists....

29 CFR 37.88 - Who may contact CRC about a complaint?

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Who may contact CRC about a complaint? 37.88 Section 37.88... PROVISIONS OF THE WORKFORCE INVESTMENT ACT OF 1998 (WIA) Compliance Procedures § 37.88 Who may contact CRC... contact CRC for information about the complaint. The Director will determine what information, if any...

KRAS polymorphisms are associated with survival of CRC in Chinese population.

Science.gov (United States)

Dai, Qiong; Wei, Hui Lian; Huang, Juan; Zhou, Tie Jun; Chai, Li; Yang, Zhi-Hui

2016-04-01

rs12245, rs12587, rs9266, rs1137282, rs61764370, and rs712 of KRAS oncogene are characterized in the 3'UTR. The study highlights the important role of these polymorphisms playing in the susceptibility, oxaliplatin-based chemotherapy sensitivity, progression, and prognosis of CRC. Improved multiplex ligation detection reaction (iMLDR) technique is used for genotyping. An unconditional logistic regression model was used to estimate the association of certain polymorphism and CRC risk. The Kaplan-Meier method, log-rank test, and Cox regression model were used to evaluate the effects of polymorphisms on survival analysis. Results demonstrated that TT genotype and T allele of rs712 were associated with the increased risk of CRC; the patients with GG genotype and G allele of rs61764370 had a shorter survival and a higher risk of relapse or metastasis of CRC. Our studies supported the conclusions that rs61764370 and rs712 polymorphisms of the KRAS are functional and it may play an important role in the development of CRC and oxaliplatin-based chemotherapy efficiency and prognosis of CRC.

Detection of colorectal cancer (CRC by urinary volatile organic compound analysis.

Directory of Open Access Journals (Sweden)

Ramesh P Arasaradnam

Full Text Available Colorectal cancer (CRC is a leading cause of cancer related death in Europe and the USA. There is no universally accepted effective non-invasive screening test for CRC. Guaiac based faecal occult blood (gFOB testing has largely been superseded by Faecal Immunochemical testing (FIT, but sensitivity still remains poor. The uptake of population based FOBt testing in the UK is also low at around 50%. The detection of volatile organic compounds (VOCs signature(s for many cancer subtypes is receiving increasing interest using a variety of gas phase analytical instruments. One such example is FAIMS (Field Asymmetric Ion Mobility Spectrometer. FAIMS is able to identify Inflammatory Bowel disease (IBD patients by analysing shifts in VOCs patterns in both urine and faeces. This study extends this concept to determine whether CRC patients can be identified through non-invasive analysis of urine, using FAIMS. 133 patients were recruited; 83 CRC patients and 50 healthy controls. Urine was collected at the time of CRC diagnosis and headspace analysis undertaken using a FAIMS instrument (Owlstone, Lonestar, UK. Data was processed using Fisher Discriminant Analysis (FDA after feature extraction from the raw data. FAIMS analyses demonstrated that the VOC profiles of CRC patients were tightly clustered and could be distinguished from healthy controls. Sensitivity and specificity for CRC detection with FAIMS were 88% and 60% respectively. This study suggests that VOC signatures emanating from urine can be detected in patients with CRC using ion mobility spectroscopy technology (FAIMS with potential as a novel screening tool.

Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis.

Science.gov (United States)

Arasaradnam, Ramesh P; McFarlane, Michael J; Ryan-Fisher, Courtenay; Westenbrink, Erik; Hodges, Phoebe; Hodges, Paula; Thomas, Matthew G; Chambers, Samantha; O'Connell, Nicola; Bailey, Catherine; Harmston, Christopher; Nwokolo, Chuka U; Bardhan, Karna D; Covington, James A

2014-01-01

Colorectal cancer (CRC) is a leading cause of cancer related death in Europe and the USA. There is no universally accepted effective non-invasive screening test for CRC. Guaiac based faecal occult blood (gFOB) testing has largely been superseded by Faecal Immunochemical testing (FIT), but sensitivity still remains poor. The uptake of population based FOBt testing in the UK is also low at around 50%. The detection of volatile organic compounds (VOCs) signature(s) for many cancer subtypes is receiving increasing interest using a variety of gas phase analytical instruments. One such example is FAIMS (Field Asymmetric Ion Mobility Spectrometer). FAIMS is able to identify Inflammatory Bowel disease (IBD) patients by analysing shifts in VOCs patterns in both urine and faeces. This study extends this concept to determine whether CRC patients can be identified through non-invasive analysis of urine, using FAIMS. 133 patients were recruited; 83 CRC patients and 50 healthy controls. Urine was collected at the time of CRC diagnosis and headspace analysis undertaken using a FAIMS instrument (Owlstone, Lonestar, UK). Data was processed using Fisher Discriminant Analysis (FDA) after feature extraction from the raw data. FAIMS analyses demonstrated that the VOC profiles of CRC patients were tightly clustered and could be distinguished from healthy controls. Sensitivity and specificity for CRC detection with FAIMS were 88% and 60% respectively. This study suggests that VOC signatures emanating from urine can be detected in patients with CRC using ion mobility spectroscopy technology (FAIMS) with potential as a novel screening tool.

CRC concise encyclopedia of mathematics

CERN Document Server

Weisstein, Eric W

2003-01-01

Upon publication, the first edition of the CRC Concise Encyclopedia of Mathematics received overwhelming accolades for its unparalleled scope, readability, and utility. It soon took its place among the top selling books in the history of Chapman & Hall/CRC, and its popularity continues unabated. Yet also unabated has been the dedication of author Eric Weisstein to collecting, cataloging, and referencing mathematical facts, formulas, and definitions. He has now updated most of the original entries and expanded the Encyclopedia to include 1000 additional pages of illustrated entries. The accessibility of the Encyclopedia along with its broad coverage and economical price make it attractive to the widest possible range of readers and certainly a must for libraries, from the secondary to the professional and research levels. For mathematical definitions, formulas, figures, tabulations, and references, this is simply the most impressive compendium available.

Reverse Taylor Tests on Ultrafine Grained Copper

International Nuclear Information System (INIS)

Mishra, A.; Meyers, M. A.; Martin, M.; Thadhani, N. N.; Gregori, F.; Asaro, R. J.

2006-01-01

Reverse Taylor impact tests have been carried out on ultrafine grained copper processed by Equal Channel Angular Pressing (ECAP). Tests were conducted on an as-received OFHC Cu rod and specimens that had undergone sequential ECAP passes (2 and 8). The average grain size ranged from 30 μm for the initial sample to less than 0.5 μm for the 8-pass samples. The dynamic deformation states of the samples, captured by high speed digital photography were compared with computer simulations run in AUTODYN-2D using the Johnson-Cook constitutive equation with constants obtained from stress-strain data and by fitting to an experimentally measured free surface velocity trace. The constitutive response of copper of varying grain sizes was obtained through quasistatic and dynamic mechanical tests and incorporation into constitutive models

Performance Analysis of CRC Codes for Systematic and Nonsystematic Polar Codes with List Decoding

Directory of Open Access Journals (Sweden)

Takumi Murata

2018-01-01

Full Text Available Successive cancellation list (SCL decoding of polar codes is an effective approach that can significantly outperform the original successive cancellation (SC decoding, provided that proper cyclic redundancy-check (CRC codes are employed at the stage of candidate selection. Previous studies on CRC-assisted polar codes mostly focus on improvement of the decoding algorithms as well as their implementation, and little attention has been paid to the CRC code structure itself. For the CRC-concatenated polar codes with CRC code as their outer code, the use of longer CRC code leads to reduction of information rate, whereas the use of shorter CRC code may reduce the error detection probability, thus degrading the frame error rate (FER performance. Therefore, CRC codes of proper length should be employed in order to optimize the FER performance for a given signal-to-noise ratio (SNR per information bit. In this paper, we investigate the effect of CRC codes on the FER performance of polar codes with list decoding in terms of the CRC code length as well as its generator polynomials. Both the original nonsystematic and systematic polar codes are considered, and we also demonstrate that different behaviors of CRC codes should be observed depending on whether the inner polar code is systematic or not.

Do recent epidemiologic observations impact who and how we should screen for CRC?

Science.gov (United States)

Bortniker, Ethan; Anderson, Joseph C

2015-03-01

Colorectal cancer (CRC) screening is recommended to begin at age 50 for those patients with no significant family history of CRC. However, even within this group of average-risk patients, there is data to suggest that there may be variation in CRC risk. These observations suggest that perhaps CRC screening should be tailored to target those patients at higher risk for earlier or more invasive screening as compared to those individuals at lower risk. The strategy of how to identify those higher-risk patients may not be straightforward. One method might be to use single risk factors such as smoking or elevated BMI as has been suggested in the recent American College of Gastroenterology CRC screening guidelines. Another paradigm involves the use of models which incorporate several risk factors to stratify patients by risk. This article will highlight recent large studies that examine recognized CRC risk factors as well as review recently developed CRC risk models. There will also be a discussion of the application of these factors and models in an effort to make CRC screening more efficient.

Non-Taylor magnetohydrodynamic self-organization

International Nuclear Information System (INIS)

Zhu, Shao-ping; Horiuchi, Ritoku; Sato, Tetsuya.

1994-10-01

A self-organization process in a plasma with a finite pressure is investigated by means of a three-dimensional magnetohydrodynamic simulation. It is demonstrated that a non-Taylor finite β self-organized state is realized in which a perpendicular component of the electric current is generated and the force-free(parallel) current decreases until they reach to almost the same level. The self-organized state is described by an MHD force-balance relation, namely, j perpendicular = B x ∇p/B·B and j parallel = μB where μ is not a constant, and the pressure structure resembles the structure of the toroidal magnetic field intensity. Unless an anomalous perpendicular thermal conduction arises, the plasma cannot relax to a Taylor state but to a non-Taylor (non-force-free) self-organized state. This state becomes more prominent for a weaker resistivity condition. The non-Taylor state has a rather universal property, for example, independence of the initial β value. Another remarkable finding is that the Taylor's conjecture of helicity conservation is, in a strict sense, not valid. The helicity dissipation occurs and its rate slows down critically in accordance with the stepwise relaxation of the magnetic energy. It is confirmed that the driven magnetic reconnection caused by the nonlinearly excited plasma kink flows plays the leading role in all of these key features of the non-Taylor self-organization. (author)

Taylor instability in rhyolite lava flows

Science.gov (United States)

Baum, B. A.; Krantz, W. B.; Fink, J. H.; Dickinson, R. E.

1989-01-01

A refined Taylor instability model is developed to describe the surface morphology of rhyolite lava flows. The effect of the downslope flow of the lava on the structures resulting from the Taylor instability mechanism is considered. Squire's (1933) transformation is developed for this flow in order to extend the results to three-dimensional modes. This permits assessing why ridges thought to arise from the Taylor instability mechanism are preferentially oriented transverse to the direction of lava flow. Measured diapir and ridge spacings for the Little and Big Glass Mountain rhyolite flows in northern California are used in conjunction with the model in order to explore the implications of the Taylor instability for flow emplacement. The model suggests additional lava flow features that can be measured in order to test whether the Taylor instability mechanism has influenced the flows surface morphology.

12 CFR 617.7310 - What is the review process of the CRC?

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false What is the review process of the CRC? 617.7310... on Applications; Review of Credit Decisions § 617.7310 What is the review process of the CRC? (a) How will an applicant or borrower know when the CRC will consider the review request? The qualified lender...

The Pseudomonas aeruginosa catabolite repression control protein Crc is devoid of RNA binding activity.

Science.gov (United States)

Milojevic, Tetyana; Grishkovskaya, Irina; Sonnleitner, Elisabeth; Djinovic-Carugo, Kristina; Bläsi, Udo

2013-01-01

The Crc protein has been shown to mediate catabolite repression control in Pseudomonas, leading to a preferential assimilation of carbon sources. It has been suggested that Crc acts as a translational repressor of mRNAs, encoding functions involved in uptake and breakdown of different carbon sources. Moreover, the regulatory RNA CrcZ, the level of which is increased in the presence of less preferred carbon sources, was suggested to bind to and sequester Crc, resulting in a relief of catabolite repression. Here, we determined the crystal structure of Pseudomonas aeruginosa Crc, a member of apurinic/apyrimidinic (AP) endonuclease family, at 1.8 Å. Although Crc displays high sequence similarity with its orthologs, there are amino acid alterations in the area corresponding to the active site in AP proteins. Unlike typical AP endonuclease family proteins, Crc has a reduced overall positive charge and the conserved positively charged amino-acid residues of the DNA-binding surface of AP proteins are partially substituted by negatively charged, polar and hydrophobic residues. Crc protein purified to homogeneity from P. aeruginosa did neither display DNase activity, nor did it bind to previously identified RNA substrates. Rather, the RNA chaperone Hfq was identified as a contaminant in His-tagged Crc preparations purified by one step Ni-affinity chromatography from Escherichia coli, and was shown to account for the RNA binding activity observed with the His-Crc preparations. Taken together, these data challenge a role of Crc as a direct translational repressor in carbon catabolite repression in P. aeruginosa.

"Kaj" je Frederick Winslow Taylor = “What” is Frederick Winslow Taylor

OpenAIRE

Andrej Markovic

2006-01-01

Raising the issue of Taylor and his scientific management after less than a hundred years seems at first glance to be quite anachronistic. Today we are more likely to find Taylor’s works in antique shops than in the libraries of the schools of management. Has the memory of utilitarian and pragmatic managerial knowledge of a century back faded, or are we in a way ashamed of Taylor, the protagononist of management? How does the research into the origin and nature of management affect the effici...

Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa.

Science.gov (United States)

Wei, Yong; Zhang, Heng; Gao, Zeng-Qiang; Xu, Jian-Hua; Liu, Quan-Sheng; Dong, Yu-Hui

2013-01-01

The global metabolic regulator catabolite repression control (Crc) has recently been found to modulate the susceptibility to antibiotics and virulence in the opportunistic pathogen Pseudomonas aeruginosa and been suggested as a nonlethal target for novel antimicrobials. In P. aeruginosa, Crc couples with the CA motifs from the small RNA CrcZ to form a post-transcriptional regulator system and is removed from the 5'-end of the target mRNAs. In this study, we first reported the crystal structure of Crc from P. aeruginosa refined to 2.20 Å. The structure showed that it consists of two halves with similar overall topology and there are 11 β strands surrounded by 13 helices, forming a four-layered α/β-sandwich. The circular dichroism spectroscopy revealed that it is thermostable in solution and shares similar characteristics to that in crystal. Comprehensive structural analysis and comparison with the homologies of Crc showed high similarity with several known nucleases and consequently may be classified into a member exodeoxyribonuclease III. However, it shows distinct substrate specificity (RNA as the preferred substrate) compared to these DNA endonucleases. Structural comparisons also revealed potential RNA recognition and binding region mainly consisting of five flexible loops. Our structure study provided the basis for the future application of Crc as a target to develop new antibiotics. Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.

Rayleigh-Taylor mixing in supernova experiments

International Nuclear Information System (INIS)

Swisher, N. C.; Abarzhi, S. I.; Kuranz, C. C.; Arnett, D.; Hurricane, O.; Remington, B. A.; Robey, H. F.

2015-01-01

We report a scrupulous analysis of data in supernova experiments that are conducted at high power laser facilities in order to study core-collapse supernova SN1987A. Parameters of the experimental system are properly scaled to investigate the interaction of a blast-wave with helium-hydrogen interface, and the induced Rayleigh-Taylor instability and Rayleigh-Taylor mixing of the denser and lighter fluids with time-dependent acceleration. We analyze all available experimental images of the Rayleigh-Taylor flow in supernova experiments and measure delicate features of the interfacial dynamics. A new scaling is identified for calibration of experimental data to enable their accurate analysis and comparisons. By properly accounting for the imprint of the experimental conditions, the data set size and statistics are substantially increased. New theoretical solutions are reported to describe asymptotic dynamics of Rayleigh-Taylor flow with time-dependent acceleration by applying theoretical analysis that considers symmetries and momentum transport. Good qualitative and quantitative agreement is achieved of the experimental data with the theory and simulations. Our study indicates that in supernova experiments Rayleigh-Taylor flow is in the mixing regime, the interface amplitude contributes substantially to the characteristic length scale for energy dissipation; Rayleigh-Taylor mixing keeps order

Colorectal cancer diagnosis in 2012: A new focus for CRC prevention--more serration, less inflammation

NARCIS (Netherlands)

East, James E.; Dekker, Evelien

2013-01-01

Knowledge of colorectal cancer (CRC) risks has been rebalanced in 2012. The 'serrated pathway' to CRC, exemplified by serrated polyposis syndrome, emphasizes the importance of serrated lesions. The dogma that patients with IBD are at high risk of CRC, however, might be overstated; optimizing CRC

CRC-cards to support development and maintenance of product configuration systems

DEFF Research Database (Denmark)

Haug, Anders; Hvam, Lars

2009-01-01

This article presents a new definition of special Class, Responsibility and Collaboration (CRC) cards to be used for the development and maintenance of Product Configuration Systems (PCSs). CRC cards were introduced as an informal and user-friendly technique for teaching object-oriented modelling...... and maintenance of PCSs. This procedure has since been applied in several configuration projects and further developed at the Centre for Product Modelling (CPM) at the Technical University of Denmark. However, the investigations of two companies that applies CRC cards to document the knowledge base of their PCSs...

Cross-regulation by CrcZ RNA controls anoxic biofilm formation in Pseudomonas aeruginosa

Science.gov (United States)

Pusic, Petra; Tata, Muralidhar; Wolfinger, Michael T.; Sonnleitner, Elisabeth; Häussler, Susanne; Bläsi, Udo

2016-12-01

Pseudomonas aeruginosa (PA) can thrive in anaerobic biofilms in the lungs of cystic fibrosis (CF) patients. Here, we show that CrcZ is the most abundant PA14 RNA bound to the global regulator Hfq in anoxic biofilms grown in cystic fibrosis sputum medium. Hfq was crucial for anoxic biofilm formation. This observation complied with an RNAseq based transcriptome analysis and follow up studies that implicated Hfq in regulation of a central step preceding denitrification. CrcZ is known to act as a decoy that sequesters Hfq during relief of carbon catabolite repression, which in turn alleviates Hfq-mediated translational repression of catabolic genes. We therefore inferred that CrcZ indirectly impacts on biofilm formation by competing for Hfq. This hypothesis was supported by the findings that over-production of CrcZ mirrored the biofilm phenotype of the hfq deletion mutant, and that deletion of the crcZ gene augmented biofilm formation. To our knowledge, this is the first example where competition for Hfq by CrcZ cross-regulates an Hfq-dependent physiological process unrelated to carbon metabolism.

33 CFR 207.170d - Taylor Creek, navigation lock (S-193) across the entrance to Taylor Creek at Lake Okeechobee...

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Taylor Creek, navigation lock (S-193) across the entrance to Taylor Creek at Lake Okeechobee, Okeechobee, Fla.; use, administration..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.170d Taylor Creek, navigation lock...

Observations on Polar Coding with CRC-Aided List Decoding

Science.gov (United States)

2016-09-01

TECHNICAL REPORT 3041 September 2016 Observations on Polar Coding with CRC-Aided List Decoding David Wasserman Approved for public release. SSC...described in [2, 3]. In FY15 and FY16 we used cyclic redundancy check (CRC)-aided polar list decoding [4]. Section 2 describes the basics of polar coding ...and gives details of the encoders and decoders we used. In the course of our research, we performed simulations of polar codes in hundreds of cases

12 CFR 617.7305 - What is a CRC and who are the members?

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false What is a CRC and who are the members? 617.7305... on Applications; Review of Credit Decisions § 617.7305 What is a CRC and who are the members? The... decisions made by a qualified lender. The CRC may only review adverse credit decisions at the request of the...

A Risk Prediction Model for Sporadic CRC Based on Routine Lab Results.

Science.gov (United States)

Boursi, Ben; Mamtani, Ronac; Hwang, Wei-Ting; Haynes, Kevin; Yang, Yu-Xiao

2016-07-01

Current risk scores for colorectal cancer (CRC) are based on demographic and behavioral factors and have limited predictive values. To develop a novel risk prediction model for sporadic CRC using clinical and laboratory data in electronic medical records. We conducted a nested case-control study in a UK primary care database. Cases included those with a diagnostic code of CRC, aged 50-85. Each case was matched with four controls using incidence density sampling. CRC predictors were examined using univariate conditional logistic regression. Variables with p value CRC prediction models which included age, sex, height, obesity, ever smoking, alcohol dependence, and previous screening colonoscopy had an AUC of 0.58 (0.57-0.59) with poor goodness of fit. A laboratory-based model including hematocrit, MCV, lymphocytes, and neutrophil-lymphocyte ratio (NLR) had an AUC of 0.76 (0.76-0.77) and a McFadden's R2 of 0.21 with a NRI of 47.6 %. A combined model including sex, hemoglobin, MCV, white blood cells, platelets, NLR, and oral hypoglycemic use had an AUC of 0.80 (0.79-0.81) with a McFadden's R2 of 0.27 and a NRI of 60.7 %. Similar results were shown in an internal validation set. A laboratory-based risk model had good predictive power for sporadic CRC risk.

How does the serrated polyp pathway alter CRC screening and surveillance?

Science.gov (United States)

Kahi, Charles J

2015-03-01

Screening and surveillance for colorectal cancer (CRC) reduces mortality through the detection of early-stage adenocarcinoma, and more importantly the detection and removal of premalignant polyps. While adenomas have historically been considered the most common and screening-relevant precursor lesions, there is accumulating evidence showing that the serrated pathway is an important contributor to CRC, and a disproportionate contributor to interval or postcolonoscopy CRC, particularly in the proximal colon. The serrated pathway is characterized by mutations in the BRAF gene, high levels of methylation of promoter CpG islands (CIMP-high), and the sessile serrated adenoma/polyp (SSA/P) is the most important precursor lesion. The study of serrated polyps has been complicated by evolving nomenclature, substantial variation among pathologists in the identification of SSA/Ps, high variability in endoscopic detection rates, and uncertainty regarding the relation to synchronous and metachronous colonic neoplasia. This paper presents an overview of the serrated polyp pathway and discusses its clinical implications including its impact on CRC screening.

76 FR 76689 - Cibola National Forest, Mount Taylor Ranger District, NM, Mount Taylor Combined Exploratory Drilling

Science.gov (United States)

2011-12-08

... National Forest, Mount Taylor Ranger District, NM, Mount Taylor Combined Exploratory Drilling AGENCY... proposed action is to approve two Plans of Operations for exploratory uranium drilling on the Cibola... San Mateo. In total, there are up to 279 drill holes that would be drilled over a period not to exceed...

29 CFR 37.38 - What information must grant applicants and recipients provide to CRC?

Science.gov (United States)

2010-07-01

... provide to CRC? 37.38 Section 37.38 Labor Office of the Secretary of Labor IMPLEMENTATION OF THE... information must grant applicants and recipients provide to CRC? In addition to the information which must be collected, maintained, and, upon request, submitted to CRC under § 37.37: (a) Each grant applicant and...

Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC.

Science.gov (United States)

Wang, Shuwei; Zhang, Weidong

2016-05-01

Interleukin (IL)-6 and the downstream Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway have previously been reported to be important in the development of colorectal cancer (CRC), and several studies have shown the relationship between the polymorphisms of related genes in this pathway with the risk of CRC. However, the findings of these related studies are inconsistent. Moreover, there has no systematic review and meta-analysis to evaluate the relationship between genetic variants in IL-6/JAK/STAT3 pathway and CRC susceptibility. Hence, we conducted a meta-analysis to explore the relationship between polymorphisms in IL-6/JAK/STAT3 pathway genes and CRC risk. Eighteen eligible studies with a total of 13,795 CRC cases and 18,043 controls were identified by searching PubMed, Web of Science, Embase, and the Cochrane Library databases for the period up to September 15, 2015. Odds ratios (ORs) and their 95 % confidence intervals (CIs) were used to calculate the strength of the association. Our results indicated that IL-6 genetic variants in allele additive model (OR = 1.05, 95 % CI = 1.00, 1.09) and JAK2 genetic variants (OR = 1.40, 95 % CI = 1.15, 1.65) in genotype recessive model were significantly associated with CRC risk. Moreover, the pooled data revealed that IL-6 rs1800795 polymorphism significantly increased the risk of CRC in allele additive model in Europe (OR = 1.07, 95 % CI = 1.01, 1.14). In conclusion, the present findings indicate that IL-6 and JAK2 genetic variants are associated with the increased risk of CRC while STAT3 genetic variants not. We need more well-designed clinical studies covering more countries and population to definitively establish the association between genetic variants in IL-6/JAK/STAT3 pathway and CRC susceptibility.

"Kaj" je Frederick Winslow Taylor = “What” is Frederick Winslow Taylor

Directory of Open Access Journals (Sweden)

Andrej Markovic

2006-06-01

Full Text Available Raising the issue of Taylor and his scientific management after less than a hundred years seems at first glance to be quite anachronistic. Today we are more likely to find Taylor’s works in antique shops than in the libraries of the schools of management. Has the memory of utilitarian and pragmatic managerial knowledge of a century back faded, or are we in a way ashamed of Taylor, the protagononist of management? How does the research into the origin and nature of management affect the efficiency of a particular manager, which seems to be the objective of management education? What is the difference between Taylor's management and contemporary management? Is it merely less scientific in approach? And where is modern management developing, if no longer in the field of exact science? And where do key notions of contemporary management, like ‘mission’ and ‘vision’ belong? Has management since its beginings proved to be only knowledge for managing organizations, or does it go beyond that? In a brief analysis of Taylor’s scientific management the author of the article tries to answer the above mentioned questions. Some of the questions are, however, only touched upon, awaiting an answer in the future.

33 CFR 117.987 - Taylor Bayou.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Taylor Bayou. 117.987 Section 117.987 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Texas § 117.987 Taylor Bayou. The draws of the Union Pacific...

O salário na obra de Frederick Winslow Taylor Frederick Winslow Taylor's oeuvre: an analysis of wages

Directory of Open Access Journals (Sweden)

Victor Paulo Gomes da Silva

2011-08-01

Full Text Available O presente artigo analisa e explica a perspectiva de Frederick Winslow Taylor sobre o salário, tal como enunciada em suas duas grandes obras: Shop management (1903 e Principles of scientific management (1911. A primeira parte consubstancia-se na apresentação de aspectos econômicos relevantes que caracterizaram o tempo em que ele viveu e o quanto influenciaram suas obras. Na segunda parte, é efetuada uma análise da forma como o salário é apresentado nas duas obras de F. W. Taylor. O artigo termina com um comentário sobre as obras supracitadas no que se refere à perspectiva taylorista do salário.This paper analyses and explains Frederick Winslow Taylor's perspective on wages, as it is presented in his main literary works: Shop management (1903 and Principles of scientific management (1911. The first part presents the main economic aspects that characterized his lifetime, which undoubtedly influenced his literary works. The second part analyses F. W. Taylor's two main books in which the author's perspective about wages is discussed. The paper concludes with a critical view of F. W. Taylor's view on wages.

33 CFR 117.335 - Taylor Creek.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Taylor Creek. 117.335 Section 117.335 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Florida § 117.335 Taylor Creek. The draw of US441 bridge, mile 0...

Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development.

Science.gov (United States)

Piao, Mei-Yu; Cao, Hai-Long; He, Na-Na; Xu, Meng-Que; Dong, Wen-Xiao; Wang, Wei-Qiang; Wang, Bang-Mao; Zhou, Bing

2016-01-01

Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in the United States. Recent cancer genome-sequencing efforts and complementary functional studies have led to the identification of a collection of candidate 'driver' genes involved in CRC tumorigenesis. Tripartite motif (TRIM3) is recently identified as a tumour suppressor in glioblastoma but this tumour-suppressive function has not been investigated in CRC. In this study, we investigated the potential role of TRIM3 as a tumour suppressor in CRC development by manipulating the expression of TRIM3 in two authentic CRC cell lines, HCT116 and DLD1, followed by various functional assays, including cell proliferation, colony formation, scratch wound healing, soft agar, and invasion assays. Xenograft experiment was performed to examine in vivo tumour-suppressive properties of TRIM3. Small-interfering RNA (siRNA) mediated knockdown of TRIM3 conferred growth advantage in CRC cells. In contrast, overexpression of TRIM3 affected cell survival, cell migration, anchorage independent growth and invasive potential in CRC cells. In addition, TRIM3 was found to be down-regulated in human colon cancer tissues compared with matched normal colon tissues. Overexpression of TRIM3 significantly inhibited tumour growth in vivo using xenograft mouse models. Mechanistic investigation revealed that TRIM3 can regulate p53 protein level through its stabilisation. TRIM3 functions as a tumour suppressor in CRC progression. This tumour-suppressive function is exerted partially through regulation of p53 protein. Therefore, this protein may represent a novel therapeutic target for prevention or intervention of CRC.

A spherical Taylor-Couette dynamo

Science.gov (United States)

Marcotte, Florence; Gissinger, Christophe

2016-04-01

We present a new scenario for magnetic field amplification in the planetary interiors where an electrically conducting fluid is confined in a differentially rotating, spherical shell (spherical Couette flow) with thin aspect-ratio. When the angular momentum sufficiently decreases outwards, a primary hydrodynamic instability is widely known to develop in the equatorial region, characterized by pairs of counter-rotating, axisymmetric toroidal vortices (Taylor vortices) similar to those observed in cylindrical Couette flow. We characterize the subcritical dynamo bifurcation due to this spherical Taylor-Couette flow and study its evolution as the flow successively breaks into wavy and turbulent Taylor vortices for increasing Reynolds number. We show that the critical magnetic Reynolds number seems to reach a constant value as the Reynolds number is gradually increased. The role of global rotation on the dynamo threshold and the implications for planetary interiors are finally discussed.

Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population.

Science.gov (United States)

Sun, Rui; Liu, Jian-Ping; Gao, Chang; Xiong, Ying-Ying; Li, Min; Wang, Ya-Ping; Su, Yan-Wei; Lin, Mei; Jiang, An-Li; Xiong, Ling-Fan; Xie, Yan; Feng, Jue-Ping

2016-05-17

Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As HHEX is a recognized susceptibility gene in T2DM, this work was focused on two SNPs in HHEX, rs1111875 and rs7923837, to study their association with CRC. T2DM patients without CRC (T2DM-only, n=300), T2DM with CRC (T2DM/CRC, n=135), cancer-free controls (Control, n=570), and CRC without T2DM (CRC-only, n=642) cases were enrolled. DNA samples were extracted from the peripheral blood leukocytes of the patients and sequenced by direct sequencing. The χ2 test was used to compare categorical data. We found that in T2DM patients, rs1111875 but not the rs7923837 in HHEX gene was associated with the occurrence of CRC (p= 0.006). for rs1111875, TC/CC patients had an increased risk of CRC (p=0.019, OR=1.592, 95%CI=1.046-2.423). Moreover, our results also indicated that the two variants of HEEX gene could be risk factors for CRC in general population, independent on T2DM (pCRC was observed in TC or TC/CC than CC individuals (pCRC risk was observed in AG, GG, and AG/GG than AA individuals (pCRC susceptibility. Risk effects and the functional impact of these polymorphisms need further validation.

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives.

Science.gov (United States)

Kahouli, Imen; Tomaro-Duchesneau, Catherine; Prakash, Satya

2013-08-01

Colorectal cancer (CRC) is the third most common form of cancer. Diverse therapies such as chemotherapy, immunotherapy and radiation have shown beneficial effects, but are limited because of their safety and toxicity. Probiotic formulations have shown great promise in CRC as preventive and early stage therapeutics. This review highlights the importance of a balanced intestinal microbiota and summarizes the recent developments in probiotics for treating CRC. Specifically, this report describes evidence of the role of probiotics in modulating the microbiota, in improving the physico-chemical conditions of the gut and in reducing oxidative stress. It also discusses the mechanisms of probiotics in inhibiting tumour progression, in producing anticancer compounds and in modulating the host immune response. Even though some of these effects were observed in several clinical trials, when probiotic formulations were used as a supplement to CRC therapies, the application of probiotics as biotherapeutics against CRC still needs further investigation.

String-theoretic deformation of the Parke-Taylor factor

Science.gov (United States)

Mizera, Sebastian; Zhang, Guojun

2017-09-01

Scattering amplitudes in a range of quantum field theories can be computed using the Cachazo-He-Yuan (CHY) formalism. In theories with color ordering, the key ingredient is the so-called Parke-Taylor factor. In this paper we give a fully SL (2 ,C )-covariant definition and study the properties of a new integrand called the "string Parke-Taylor" factor. It has an α' expansion whose leading coefficient is the field-theoretic Parke-Taylor factor. Its main application is that it leads to a CHY formulation of open string tree-level amplitudes. In fact, the definition of the string Parke-Taylor factor was motivated by trying to extend the compact formula for the first α' correction found by He and Zhang, while the main ingredient in its definition is a determinant of a matrix introduced in the context of string theory by Stieberger and Taylor.

ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC.

Science.gov (United States)

Lazarova, Darina; Bordonaro, Michael

2017-01-01

We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed as therapeutic agents against CRC. We have previously discussed that resistance to butyrate likely contributes to colonic carcinogenesis, and we have demonstrated that butyrate resistance leads to cross-resistance to cancer therapeutic HDACis. Deregulated Wnt signaling is the major initiating event in most CRC cases. One mechanism whereby butyrate and other HDACis exert their anti-CRC effects is via Wnt signaling hyperactivation, which promotes CRC cell apoptosis. The histone acetylases (HATs) CBP and p300 are mediators of Wnt transcriptional activity, and play divergent roles in the downstream consequences of Wnt signaling. CBP-mediated Wnt signaling is associated with cell proliferation and stem cell maintenance; whereas, p300-mediated Wnt activity is associated with differentiation. We have found that CBP and p300 differentially affect the ability of butyrate to influence Wnt signaling, apoptosis, and proliferation. ZEB 1 is a Wnt signaling-targeted gene, whose product is a transcription factor expressed at the invasive front of carcinomas where it promotes malignant progression and EMT. ZEB1 is typically a transcriptional repressor; however, when associated with p300, ZEB1 enhances transcription. These changes in ZEB1 activity likely affect the cancer cell phenotype. ZEB1 has been shown to promote resistance to chemotherapeutic agents, and expression of ZEB1 is upregulated in butyrate-resistant CRC cells that lack p300 expression. Since the expression of ZEB1 correlates with poor outcomes in cancer, ZEB represents a relevant therapeutic target. Here we propose that targeting the signaling network established by ZEB1, Wnt signaling, and p300

Non-vanishing of Taylor coefficients and Poincaré series

DEFF Research Database (Denmark)

O'Sullivan, C.; Risager, Morten S.

2013-01-01

We prove recursive formulas for the Taylor coefficients of cusp forms, such as Ramanujan's Delta function, at points in the upper half-plane. This allows us to show the non-vanishing of all Taylor coefficients of Delta at CM points of small discriminant as well as the non-vanishing of certain...... Poincaré series. At a "generic" point, all Taylor coefficients are shown to be non-zero. Some conjectures on the Taylor coefficients of Delta at CM points are stated....

Taylor series maps and their domain of convergence

International Nuclear Information System (INIS)

Abell, D.T.; Dragt, A.J.

1992-01-01

This paper tries to make clear what limits the validity of a Taylor series map, and how. We describe the concept of a transfer map and quote some theorems that justify not only their existence but also their advantages. Then, we describe the Taylor series representation for transfer maps. Following that, we attempt to elucidate some of the basic theorems from the theory of functions of one and several complex variables. This material forms the core of our understanding of what limits the domain of convergence of Taylor series maps. Lastly, we use the concrete example of a simple anharmonic oscillator to illustrate how the theorems from several complex variable theory affect the domain convergence of Taylor series maps. There we describe the singularities of the anharmonic oscillator in the complex planes of the initial conditions, show how they constrain our use of a Taylor series map, and then discuss our findings

Taylorism and the Logic of Learning Outcomes

Science.gov (United States)

Stoller, Aaron

2015-01-01

This essay examines the shared philosophical foundations of Fredrick W. Taylor's scientific management principles and the contemporary learning outcomes movement (LOM). It analyses the shared philosophical ground between the focal point of Taylor's system--"the task"--and the conceptualization and deployment of "learning…

Long noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment.

Science.gov (United States)

Wu, Kaiming; Zhao, Zhenxian; Liu, Kuanzhi; Zhang, Jian; Li, Guanghua; Wang, Liang

2017-07-03

Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biologic processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis. Our results also showed that the expression of indoleamine 2,3-dioxygenase 1 (IDO1) was significantly reduced by lnc-sox5 knock-down and therefore modulated the infiltration and cytotoxicity of CD3 + CD8 + T cells. Taken together, these results suggested that lnc-sox5 unbalances tumor microenvironment to regulate colorectal cancer progression.

Simulation of Rayleigh--Taylor flows using vortex blobs

International Nuclear Information System (INIS)

Kerr, R.M.

1988-01-01

An inviscid boundary-integral method is modified in order to study the single-scale Rayleigh--Taylor instability for arbitrary Atwood number. The primary modification uses vortex blobs to smooth the Green's function and suppress a finite time singularity in the curvature. Additional modifications to earlier codes such as using second-order central differences along the interface to accommodate spikes in the vorticity and spreading the nodes evenly along the interface to suppress clustering of nodes are designed to maintain resolution and accuracy. To achieve second-order accuracy in time when the nodes are spread, an extra predictor step is needed that shifts the nodes before the variables are advanced. The method successfully follows the development of a single mode to states with asymptotic velocities for the bubble and spike that depend on the Atwood number and are independent of the blob size. Incipient droplet formation is observed. copyright 1988 Academic Press, Inc

The Life and Legacy of G. I. Taylor

Science.gov (United States)

Batchelor, G. K.

1996-07-01

G.I. Taylor, one of the most distinguished physical scientists of this century, used his deep insight and originality to increase our understanding of phenomena such as the turbulent flow of fluids. His interest in the science of fluid flow was not confined to theory; he was one of the early pioneers of aeronautics, and designed a new type of anchor that was inspired by his passion for sailing. Taylor spent most of his working life in the Cavendish Laboratory in Cambridge, where he investigated the mechanics of fluid and solid materials; his discoveries and ideas have had application throughout mechanical, civil, and chemical engineering, meteorology, oceanography and materials science. He was also a noted research leader, and his group in Cambridge became one of the most productive centers for the study of fluid mechanics. How was Taylor able to be innovative in so many different ways? This interesting and unusual biography helps answer that question. Professor Batchelor, himself a student and close collaborator of Taylor, is ideally placed to describe Taylor's life, achievements and background. He does so without introducing any mathematical details, making this book enjoyable reading for a wide range of people--and especially those whose own interests have brought them into contact with the legacy of Taylor.

Educar na autenticidade em Charles Taylor = Educating in the authenticity in Charles Taylor

Directory of Open Access Journals (Sweden)

Foschiera, Rogério

2009-01-01

Full Text Available Analiso a perspectiva tayloriana da autencidade através de uma hermenêutica de suas principais obras para propor o significado de educar na autencticidade a partir de Charles Taylor. Com autencidade e ontologia moral Taylor apresenta uma antropologia ancorada na moral e na ontologia. Com autencidade e epistemologia se percebe que a perspectiva da autencidade não exclui o paradigma científico, mas necessita de outros paradigmas, principalmente do hermenêutico. Com autencidade e linguagem evidencio a compreensão de Taylor sobre a natureza da linguagem e o destaque que ele dá á definição de ser humano como "animal portador de logos", bem como o significado e as decorrências da perspectiva expressivista. Duas políticas: a da igualdade de direitos de todos e a do reconhecimento das diferenças estão integradas na perspectiva tayloriana da autencidade. Necessariamente, o ser humano, para ser autêntico, estará em constante referência a horizontes de sentido que transcendem o indivíduo, é o que apresento com autencidade e transcendência

29 CFR 37.84 - What happens if CRC does not have jurisdiction over a complaint?

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true What happens if CRC does not have jurisdiction over a complaint? 37.84 Section 37.84 Labor Office of the Secretary of Labor IMPLEMENTATION OF THE... Procedures § 37.84 What happens if CRC does not have jurisdiction over a complaint? If CRC does not have...

Association between hMLH1 hypermethylation and JC virus (JCV) infection in human colorectal cancer (CRC).

Science.gov (United States)

Vilkin, Alex; Niv, Yaron

2011-04-01

Incorporation of viral DNA may interfere with the normal sequence of human DNA bases on the genetic level or cause secondary epigenetic changes such as gene promoter methylation or histone acetylation. Colorectal cancer (CRC) is the second leading cause of cancer mortality in the USA. Chromosomal instability (CIN) was established as the key mechanism in cancer development. Later, it was found that CRC results not only from the progressive accumulation of genetic alterations but also from epigenetic changes. JC virus (JCV) is a candidate etiologic factor in sporadic CRC. It may act by stabilizing β-catenin, facilitating its entrance to the cell nucleus, initialing proliferation and cancer development. Diploid CRC cell lines transfected with JCV-containing plasmids developed CIN. This result provides direct experimental evidence for the ability of JCV T-Ag to induce CIN in the genome of colonic epithelial cells. The association of CRC hMLH1 methylation and tumor positivity for JCV was recently documented. JC virus T-Ag DNA sequences were found in 77% of CRCs and are associated with promoter methylation of multiple genes. hMLH1 was methylated in 25 out of 80 CRC patients positive for T-Ag (31%) in comparison with only one out of 11 T-Ag negative cases (9%). Thus, JCV can mediate both CIN and aberrant methylation in CRC. Like other viruses, chronic infection with JCV may induce CRC by different mechanisms which should be further investigated. Thus, gene promoter methylation induced by JCV may be an important process in CRC and the polyp-carcinoma sequence.

RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.

Science.gov (United States)

Wang, Xiao-Yan; Li, Sheng-Nan; Zhu, Hui-Fang; Hu, Zhi-Yan; Zhong, Yan; Gu, Chuan-Sha; Chen, Shi-You; Liu, Teng-Fei; Li, Zu-Guo

2017-05-04

Response gene to complement 32 (RGC32) is a transcription factor that regulates the expression of multiple genes involved in cell growth, viability and tissue-specific differentiation. However, the role of RGC32 in tumorigenesis and tumor progression in colorectal cancer (CRC) has not been fully elucidated. Here, we showed that the expression of RGC32 was significantly up-regulated in human CRC tissues versus adjacent normal tissues. RGC32 expression was significantly correlated with invasive and aggressive characteristics of tumor cells, as well as poor survival of CRC patients. We also demonstrated that RGC32 overexpression promoted proliferation, migration and tumorigenic growth of human CRC cells in vitro and in vivo. Functionally, RGC32 facilitated epithelial-mesenchymal transition (EMT) in CRC via the Smad/Sip1 signaling pathway, as shown by decreasing E-cadherin expression and increasing vimentin expression. In conclusion, our findings suggested that overexpression of RGC32 facilitates EMT of CRC cells by activating Smad/Sip1 signaling.

On truncated Taylor series and the position of their spurious zeros

DEFF Research Database (Denmark)

Christiansen, Søren; Madsen, Per A.

2006-01-01

A truncated Taylor series, or a Taylor polynomial, which may appear when treating the motion of gravity water waves, is obtained by truncating an infinite Taylor series for a complex, analytical function. For such a polynomial the position of the complex zeros is considered in case the Taylor...

Taylor's series method for solving the nonlinear point kinetics equations

International Nuclear Information System (INIS)

Nahla, Abdallah A.

2011-01-01

Highlights: → Taylor's series method for nonlinear point kinetics equations is applied. → The general order of derivatives are derived for this system. → Stability of Taylor's series method is studied. → Taylor's series method is A-stable for negative reactivity. → Taylor's series method is an accurate computational technique. - Abstract: Taylor's series method for solving the point reactor kinetics equations with multi-group of delayed neutrons in the presence of Newtonian temperature feedback reactivity is applied and programmed by FORTRAN. This system is the couples of the stiff nonlinear ordinary differential equations. This numerical method is based on the different order derivatives of the neutron density, the precursor concentrations of i-group of delayed neutrons and the reactivity. The r th order of derivatives are derived. The stability of Taylor's series method is discussed. Three sets of applications: step, ramp and temperature feedback reactivities are computed. Taylor's series method is an accurate computational technique and stable for negative step, negative ramp and temperature feedback reactivities. This method is useful than the traditional methods for solving the nonlinear point kinetics equations.

12 CFR 617.7315 - What records must the qualified lender maintain on behalf of the CRC?

Science.gov (United States)

2010-01-01

... on behalf of the CRC? 617.7315 Section 617.7315 Banks and Banking FARM CREDIT ADMINISTRATION FARM... must the qualified lender maintain on behalf of the CRC? A qualified lender must maintain a complete file of all requests for CRC reviews, including participation in state mediation programs, the minutes...

76 FR 3570 - Proposed Amendment of Class E Airspace; Taylor, AZ

Science.gov (United States)

2011-01-20

...-1189; Airspace Docket No. 10-AWP-19] Proposed Amendment of Class E Airspace; Taylor, AZ AGENCY: Federal... proposes to modify Class E airspace at Taylor Airport, Taylor, AZ. Controlled airspace is necessary to accommodate aircraft using the CAMBO One Departure Area Navigation (RNAV) out of Taylor Airport. The FAA is...

Report: Cultural Research Centre (CRC)

OpenAIRE

Cross-Cultural Foundation of Uganda

2010-01-01

This report arises from research carried out in Iganga and Namutumba districts in late 2006/early 2007 by the Cultural Research Centre (CRC), based in Jinja. Our research focus was to gauge the impact of using Lusoga as a medium of instruction (since 2005 in "pilot" lower primary classes) within and outside the classroom. This initiative was in response to a new set of circumstances in the education sector in Uganda, especially the introduction by Government of teaching in local languages in ...

Influence of the Hfq and Crc global regulators on the control of iron homeostasis in Pseudomonas putida.

Science.gov (United States)

Sánchez-Hevia, Dione L; Yuste, Luis; Moreno, Renata; Rojo, Fernando

2018-04-30

Metabolically versatile bacteria use catabolite repression control to select their preferred carbon sources, thus optimizing carbon metabolism. In pseudomonads, this occurs through the combined action of the proteins Hfq and Crc, which form stable tripartite complexes at target mRNAs, inhibiting their translation. The activity of Hfq/Crc is antagonised by small RNAs of the CrcZ family, the amounts of which vary according to carbon availability. The present work examines the role of Pseudomonas putida Hfq protein under conditions of low-level catabolite repression, in which Crc protein would have a minor role since it is sequestered by CrcZ/CrcY. The results suggest that, under these conditions, Hfq remains operative and plays an important role in iron homeostasis. In this scenario, Crc appears to participate indirectly by helping CrcZ/CrcY to control the amount of free Hfq in the cell. Iron homeostasis in pseudomonads relies on regulatory elements such as the Fur protein, the PrrF1-F2 sRNAs, and several extracytoplasmic sigma factors. Our results show that the absence of Hfq is paralleled by a reduction in PrrF1-F2 small RNAs. Hfq thus provides a regulatory link between iron and carbon metabolism, coordinating the iron supply to meet the needs of the enzymes operational under particular nutritional regimes. This article is protected by copyright. All rights reserved. © 2018 Society for Applied Microbiology and John Wiley & Sons Ltd.

Virulence of Pseudomonas syringae pv. tomato DC3000 Is Influenced by the Catabolite Repression Control Protein Crc.

Science.gov (United States)

Chakravarthy, Suma; Butcher, Bronwyn G; Liu, Yingyu; D'Amico, Katherine; Coster, Matthew; Filiatrault, Melanie J

2017-04-01

Pseudomonas syringae infects diverse plant species and is widely used as a model system in the study of effector function and the molecular basis of plant diseases. Although the relationship between bacterial metabolism, nutrient acquisition, and virulence has attracted increasing attention in bacterial pathology, it is largely unexplored in P. syringae. The Crc (catabolite repression control) protein is a putative RNA-binding protein that regulates carbon metabolism as well as a number of other factors in the pseudomonads. Here, we show that deletion of crc increased bacterial swarming motility and biofilm formation. The crc mutant showed reduced growth and symptoms in Arabidopsis and tomato when compared with the wild-type strain. We have evidence that the crc mutant shows delayed hypersensitive response (HR) when infiltrated into Nicotiana benthamiana and tobacco. Interestingly, the crc mutant was more susceptible to hydrogen peroxide, suggesting that, in planta, the mutant may be sensitive to reactive oxygen species generated during pathogen-associated molecular pattern-triggered immunity (PTI). Indeed, HR was further delayed when PTI-induced tissues were challenged with the crc mutant. The crc mutant did not elicit an altered PTI response in plants compared with the wild-type strain. We conclude that Crc plays an important role in growth and survival during infection.

Application of Taylor-Series Integration to Reentry Problems with Wind

NARCIS (Netherlands)

Bergsma, Michiel; Mooij, E.

2016-01-01

Taylor-series integration is a numerical integration technique that computes the Taylor series of state variables using recurrence relations and uses this series to propagate the state in time. A Taylor-series integration reentry integrator is developed and compared with the fifth-order

Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa.

Science.gov (United States)

Sonnleitner, Elisabeth; Wulf, Alexander; Campagne, Sébastien; Pei, Xue-Yuan; Wolfinger, Michael T; Forlani, Giada; Prindl, Konstantin; Abdou, Laetitia; Resch, Armin; Allain, Frederic H-T; Luisi, Ben F; Urlaub, Henning; Bläsi, Udo

2018-02-16

In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) act as post-transcriptional regulators during carbon catabolite repression (CCR). In this regard Crc is required for full-fledged Hfq-mediated translational repression of catabolic genes. RNAseq based transcriptome analyses revealed a significant overlap between the Crc and Hfq regulons, which in conjunction with genetic data supported a concerted action of both proteins. Biochemical and biophysical approaches further suggest that Crc and Hfq form an assembly in the presence of RNAs containing A-rich motifs, and that Crc interacts with both, Hfq and RNA. Through these interactions, Crc enhances the stability of Hfq/Crc/RNA complexes, which can explain its facilitating role in Hfq-mediated translational repression. Hence, these studies revealed for the first time insights into how an interacting protein can modulate Hfq function. Moreover, Crc is shown to interfere with binding of a regulatory RNA to Hfq, which bears implications for riboregulation. These results are discussed in terms of a working model, wherein Crc prioritizes the function of Hfq toward utilization of favored carbon sources.

Generalization of the Taylor Principle

International Nuclear Information System (INIS)

Jensen, T.H.

1986-01-01

The usual Taylor Principle can in general only be applied when the system is closed. This paper describes a suggestion of a generalization to cover the case that the plasma is surrounded by a conducting shell with narrow gaps where the external circuits connected to the gaps consist of just inductors. The suggested constraint of the generalized Taylor Principle is that no helicity is absorbed by the plasma. The usual assumption that the stable Taylor Equilibrium is that for which the magnetic energy in the plasma region as well as in the external inductors is minimized subject to the above constraint, again leads to a unique configuration. It is found that this configuration is dependent upon the inductances of the external inductors. For the sake of conceptual simplicity, consider a closed shell of conducting material. The interior of the shell may be divided into various compartments only corrected through narrow gaps in the conducting walls between these compartments. They assume plasma present in only one of the compartments; the neighboring compartments represent the external inductors connected across the gaps of the plasma compartment

The New Taylorism: Hacking at the Philosophy of the University's End

Science.gov (United States)

Goodman, Robin Truth

2012-01-01

This article looks at the critical writings of Mark C. Taylor. It suggests that Mark C. Taylor is rewriting a global imaginary devoid of the kind of citizenship that Henry Giroux claims as the basis for public education. Instead, Taylor wants to see the university take shape as profit-generating. According to Taylor, in lieu of learning to take…

CRC handbook of modern telecommunications

CERN Document Server

Morreale, Patricia A

2001-01-01

This authoritative handbook, contributed to by a team of international experts, covers the most dynamic areas in the changing telecommunications landscape. Written for telecommunications specialists who implement the new technologies, The CRC Handbook of Modern Telecommunications is an excellent companion volume to the authors' The Telecommunications Handbook, but stands well on its own, as it extends the range of topics to include voice over Internet, traffic management, quality of service, and other dominant future trends. It is an indispensable reference for all professionals working in the

Dynamic Transition and Pattern Formation in Taylor Problem

Institute of Scientific and Technical Information of China (English)

Tian MA; Shouhong WANG

2010-01-01

The main objective of this article is to study both dynamic and structural transitions of the Taylor-Couette flow,by using the dynamic transition theory and geometric theory of incompressible flows developed recently by the authors.In particular,it is shown that as the Taylor number crosses the critical number,the system undergoes either a continuous or a jump dynamic transition,dictated by the sign of a computable,nondimensional parameter R.In addition,it is also shown that the new transition states have the Taylor vortex type of flow structure,which is structurally stable.

76 FR 18378 - Amendment of Class E Airspace; Taylor, AZ

Science.gov (United States)

2011-04-04

...-1189; Airspace Docket No. 10-AWP-19] Amendment of Class E Airspace; Taylor, AZ AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action will amend Class E airspace at Taylor Airport, Taylor, AZ, to accommodate aircraft using the CAMBO One Departure, and the Area Navigation (RNAV...

Fluid Mechanics of Taylor Bubbles and Slug Flows in Vertical Channels

International Nuclear Information System (INIS)

Anglart, Henryk; Podowski, Michael Z.

2002-01-01

Fluid mechanics of Taylor bubbles and slug flows is investigated in vertical, circular channels using detailed, three-dimensional computational fluid dynamics simulations. The Volume of Fluid model with the interface-sharpening algorithm, implemented in the commercial CFX4 code, is used to predict the shape and velocity of Taylor bubbles moving along a vertical channel. Several cases are investigated, including both a single Taylor bubble and a train of bubbles rising in water. It is shown that the potential flow solution underpredicts the water film thickness around Taylor bubbles. Furthermore, the computer simulations that are performed reveal the importance of properly modeling the three-dimensional nature of phenomena governing the motion of Taylor bubbles. Based on the present results, a new formula for the evaluation of bubble shape is derived. Both the shape of Taylor bubbles and the bubble rise velocity predicted by the proposed model agree well with experimental observations. Furthermore, the present model shows good promise in predicting the coalescence of Taylor bubbles

Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions.

Science.gov (United States)

Mohapatra, Shyam S; Batra, Surinder K; Bharadwaj, Srinivas; Bouvet, Michael; Cosman, Bard; Goel, Ajay; Jogunoori, Wilma; Kelley, Michael J; Mishra, Lopa; Mishra, Bibhuti; Mohapatra, Subhra; Patel, Bhaumik; Pisegna, Joseph R; Raufman, Jean-Pierre; Rao, Shuyun; Roy, Hemant; Scheuner, Maren; Singh, Satish; Vidyarthi, Gitanjali; White, Jon

2018-05-01

Colorectal cancer (CRC) accounts for ~9% of all cancers in the Veteran population, a fact which has focused a great deal of the attention of the VA's research and development efforts. A field-based meeting of CRC experts was convened to discuss both challenges and opportunities in precision medicine for CRC. This group, designated as the VA Colorectal Cancer Cell-genomics Consortium (VA4C), discussed advances in CRC biology, biomarkers, and imaging for early detection and prevention. There was also a discussion of precision treatment involving fluorescence-guided surgery, targeted chemotherapies and immunotherapies, and personalized cancer treatment approaches. The overarching goal was to identify modalities that might ultimately lead to personalized cancer diagnosis and treatment. This review summarizes the findings of this VA field-based meeting, in which much of the current knowledge on CRC prescreening and treatment was discussed. It was concluded that there is a need and an opportunity to identify new targets for both the prevention of CRC and the development of effective therapies for advanced disease. Also, developing methods integrating genomic testing with tumoroid-based clinical drug response might lead to more accurate diagnosis and prognostication and more effective personalized treatment of CRC.

The Rayleigh-Taylor instability in the spherical pinch

International Nuclear Information System (INIS)

Chen, H.B.; Hilko, B.; Panarella, E.

1994-01-01

The spherical pinch (SP) concept is an outgrowth of the inertial confinement model (ICF). Unlike the ICF where instabilities, especially the Rayleigh-Taylor instability, have been studied extensively, the instability study of the spherical pinch has just begun. The Raleigh-Taylor instability is investigated for the first time in the SP in the present work. By using the simple condition for the Rayleigh-Taylor instability ∇p · ∇p < O (density and pressure gradients have opposite direction), we have qualitatively identified the regions for development of instabilities in the SP. It is found that the explosion phase (central discharge) is stable and instabilities take place in the imploding phase. However, the growth rate for the instability is not in exponential form, and the appearance of the Rayleigh-Taylor instability does not prevent the main shock wave from converging to the center of the sphere

Therapeutic value of EGFR inhibition in CRC and NSCLC: 15 years of clinical evidence.

Science.gov (United States)

Troiani, Teresa; Napolitano, Stefania; Della Corte, Carminia Maria; Martini, Giulia; Martinelli, Erika; Morgillo, Floriana; Ciardiello, Fortunato

2016-01-01

Epidermal growth factor receptor (EGFR) plays a key role in tumour evolution, proliferation and immune evasion, and is one of the most important targets for biological therapy, especially for non-small-cell lung cancer (NSCLC) and colorectal cancer (CRC). In the past 15 years, several EGFR antagonists have been approved for the treatment of NSCLC and metastatic CRC (mCRC). To optimise the use of anti-EGFR agents in clinical practice, various clinical and molecular biomarkers have been investigated, thus moving their indication from unselected to selected populations. Nowadays, anti-EGFR drugs represent a gold-standard therapy for metastatic NSCLC harbouring EGFR activating mutation and for RAS wild-type mCRC. Their clinical efficacy is limited by the presence of intrinsic resistance or the onset of acquired resistance. In this review, we provide an overview of the antitumour activity of EGFR inhibitors in NSCLC and CRC and of mechanisms of resistance, focusing on the development of a personalised approach through 15 years of preclinical and clinical research.

G.I. Taylor and the Trinity Test

Science.gov (United States)

Deakin, Michael A. B.

2011-01-01

The story is often told of the calculation by G.I. Taylor of the yield of the first ever atomic bomb exploded in New Mexico in 1945. It has indeed become a staple of the classroom whenever dimensional analysis is taught. However, while it is true that Taylor succeeded in calculating this figure at a time when it was still classified, most versions…

MEG3 is a prognostic factor for CRC and promotes chemosensitivity by enhancing oxaliplatin-induced cell apoptosis.

Science.gov (United States)

Li, Lixia; Shang, Jian; Zhang, Yupeng; Liu, Shi; Peng, Yanan; Zhou, Zhou; Pan, Huaqing; Wang, Xiaobing; Chen, Lipng; Zhao, Qiu

2017-09-01

A major reason for the failure of advanced colorectal cancer (CRC) treatment is the occurrence of chemoresistance to oxaliplatin-based chemotherapy. Recently, studies have shown that long non-coding RNAs (lncRNAs) play an important role in drug resistance. Using HiSeq sequencing methods, we identified that lncRNAs show differential expression levels in oxaliplatin-resistant (OxR) and non-resistant CRC patients. RT-qPCR was then performed in tissues and serum samples, and lncRNA MEG3 was verified to be downregulated in non-responding patients and to have considerable discriminating potential to identify responding patients from non-responding patients. Moreover, decreased serum MEG3 expression was associated with poor chemoresponse and low survival rate in CRC patients receiving oxaliplatin treatment. Subsequently, OxR cell lines were established, and MEG3 was significantly downregulated in HT29 OxR and SW480 OxR cells. In addition, overexpression of MEG3 with pMEG3 reversed oxaliplatin resistance in both CRC cell lines. Flow cytometric apoptosis analysis indicated that MEG3 promoted CRC cell apoptosis. More importantly, MEG3 enhanced oxaliplatin‑induced cell cytotoxicity in CRC. In conclusion, our integrated approach demonstrated that decreased expression of lncRNA MEG3 in CRC confers potent poor therapeutic efficacy, and that MEG3 promotes chemosensitivity by enhancing oxaliplatin-induced cell apoptosis. Thus, overexpression of MEG3 may be a future direction by which to develop a novel therapeutic strategy to overcome oxaliplatin resistance of CRC patients.

Effects of shock waves on Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Zhang Yongtao; Shu Chiwang; Zhou Ye

2006-01-01

A numerical simulation of two-dimensional compressible Navier-Stokes equations using a high-order weighted essentially nonoscillatory finite difference shock capturing scheme is carried out in this paper, to study the effect of shock waves on the development of Rayleigh-Taylor instability. Shocks with different Mach numbers are introduced ahead or behind the Rayleigh-Taylor interface, and their effect on the transition to instability is demonstrated and compared. It is observed that shock waves can speed up the transition to instability for the Rayleigh-Taylor interface significantly. Stronger shocks are more effective in this speed-up process

Novel targets of the CbrAB/Crc carbon catabolite control system revealed by transcript abundance in Pseudomonas aeruginosa.

Science.gov (United States)

Sonnleitner, Elisabeth; Valentini, Martina; Wenner, Nicolas; Haichar, Feth el Zahar; Haas, Dieter; Lapouge, Karine

2012-01-01

The opportunistic human pathogen Pseudomonas aeruginosa is able to utilize a wide range of carbon and nitrogen compounds, allowing it to grow in vastly different environments. The uptake and catabolism of growth substrates are organized hierarchically by a mechanism termed catabolite repression control (Crc) whereby the Crc protein establishes translational repression of target mRNAs at CA (catabolite activity) motifs present in target mRNAs near ribosome binding sites. Poor carbon sources lead to activation of the CbrAB two-component system, which induces transcription of the small RNA (sRNA) CrcZ. This sRNA relieves Crc-mediated repression of target mRNAs. In this study, we have identified novel targets of the CbrAB/Crc system in P. aeruginosa using transcriptome analysis in combination with a search for CA motifs. We characterized four target genes involved in the uptake and utilization of less preferred carbon sources: estA (secreted esterase), acsA (acetyl-CoA synthetase), bkdR (regulator of branched-chain amino acid catabolism) and aroP2 (aromatic amino acid uptake protein). Evidence for regulation by CbrAB, CrcZ and Crc was obtained in vivo using appropriate reporter fusions, in which mutation of the CA motif resulted in loss of catabolite repression. CbrB and CrcZ were important for growth of P. aeruginosa in cystic fibrosis (CF) sputum medium, suggesting that the CbrAB/Crc system may act as an important regulator during chronic infection of the CF lung.

DcR3 induces epithelial-mesenchymal transition through activation of the TGF-β3/SMAD signaling pathway in CRC.

Science.gov (United States)

Liu, Yan-Ping; Zhu, Hui-Fang; Liu, Ding-Li; Hu, Zhi-Yan; Li, Sheng-Nan; Kan, He-Ping; Wang, Xiao-Yan; Li, Zu-Guo

2016-11-22

Decoy receptor 3 (DcR3), a novel member of the tumor necrosis factor receptor (TNFR) family, was recently reported to be associated with tumorigenesis and metastasis. However, the role of DcR3 in human colorectal cancer (CRC) has not been fully elucidated. In this study, we found that DcR3 expression was significantly higher in human colorectal cancer tissues than in paired normal tissues, and that DcR3 expression was strongly correlated with tumor invasion, lymph node metastases and poor prognoses. Moreover, DcR3 overexpression significantly enhanced CRC cell proliferation and migration in vitro and tumorigenesis in vivo. Conversely, DcR3 knockdown significantly repressed CRC cell proliferation and migration in vitro, and DcR3 deficiency also attenuated CRC tumorigenesis and metastasis in vivo. Functionally, DcR3 was essential for TGF-β3/SMAD-mediated epithelial-mesenchymal transition (EMT) of CRC cells. Importantly, cooperation between DcR3 and TGF-β3/SMAD-EMT signaling-related protein expression was correlated with survival and survival time in CRC patients. In conclusion, our results demonstrate that DcR3 may be a prognostic biomarker for CRC and that this receptor facilitates CRC development and metastasis by participating in TGF-β3/SMAD-mediated EMT of CRC cells.

Mucin Expression in Colorectal Cancer (CRC): Systematic Review and Meta-Analysis.

Science.gov (United States)

Niv, Yaron; Rokkas, Theodore

2018-05-18

A body of evidence has suggested that mucins play an important role in adhesion, invasion, and cancer metastasis. However, this evidence is scarce and sometimes confusing. We performed a systematic review and meta-analysis of available studies to better define the role of mucins in the behavior of colorectal cancer (CRC). Medical literature was searched through November 30, 2017, using suitable keywords. Pooled estimates, that is, odd ratios (ORs), were obtained using fixed or random-effects models, as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test and I values, whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the Begg and Mazumdar adjusted rank correlation test and by the Egger regression test. A total of 2234 CRC patients were included in 12 studies, eligible for meta-analysis. There was a significant difference concerning total mucin expression between CRC patients and controls [pooled ORs (95% confidence interval)=8.156 (2.624-25.354), test for overall effect Z=3.627, PCRC, that is advanced stage versus localized disease [ORs (95% confidence interval)=2.724 (1.211-6.127), Z= 2.423, P=0.015], as opposed to MUC2 and MUC4. MUC1 is overexpressed in CRC tissue comparing with healthy mucosa, and may have a role in the neoplastic transformation and metastatic process. MUC2 has probably no role in carcinogenesis.

Juan H. Vera and Grazyna Wilczek-Vera: Classical Thermodynamics of Fluid Systems: Principles and Applications. CRC Press, Taylor & Francis Group

DEFF Research Database (Denmark)

Kontogeorgis, Georgios

2017-01-01

The book Classical Thermodynamics of Fluid Systems: Principles and Applications written by professor Juan H. Vera and Dr. Grazyna Wilczek-Vera is undoubtably a book written in a most personal style by the two distinguished authors.The book contains four sections and a fifth one with appendices...

“What” is Frederick Winslow Taylor

OpenAIRE

Andrej Markovic

2006-01-01

Raising the issue of Taylor and his scientific management after less than a hundred years seems at first glance to be quite anachronistic. Today we are more likely to find Taylor’s works in antique shops than in the libraries of the schools of management. Has the memory of utilitarian and pragmatic managerial knowledge of a century back faded, or are we in a way ashamed of Taylor, the protagononist of management? How does the research into the origin and nature of management affect the effici...

DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.

Science.gov (United States)

Tang, Jieting; Chen, Huarong; Wong, Chi-Chun; Liu, Dabin; Li, Tong; Wang, Xiaohong; Ji, Jiafu; Sung, Joseph Jy; Fang, Jing-Yuan; Yu, Jun

2018-03-14

Copy number alterations (CNAs) are crucial for colorectal cancer (CRC) development. In this study, DEAD box polypeptide 27 (DDX27) was identified to be highly amplified in both TCGA CRC (474/615) and primary CRC (47/103), which was positively correlated with its mRNA overexpression. High DDX27 mRNA (N = 199) and protein expression (N = 260) predicted poor survival in CRC patients. Ectopic expression of DDX27 increased CRC cells proliferation, migration and invasion, but suppressed apoptosis. Conversely, silencing of DDX27 exerted opposite effects in vitro and significantly inhibited murine xenograft tumor growth and lung metastasis in vivo. Up-regulation of DDX27 enhanced and prolonged TNF-α-mediated NF-κB signaling. Nucleophosmin (NPM1) was identified as a binding partner of DDX27. DDX27 increased nuclear NPM1 and NF-κB-p65 interaction to enhance DNA binding activity of NF-κB. Silencing NPM1 abrogated DDX27-activating NF-κB signaling and its tumor-promoting function. Together, DDX27 is overexpressed and plays a pivotal oncogenic role in CRC.

miR-133b down-regulates ABCC1 and enhances the sensitivity of CRC to anti-tumor drugs.

Science.gov (United States)

Chen, Miao; Li, Daojiang; Gong, Ni; Wu, Hao; Su, Chen; Xie, Canbin; Xiang, Hong; Lin, Changwei; Li, Xiaorong

2017-08-08

Multidrug resistance (MDR) is the main cause of failed chemotherapy treatments. Therefore, preventing MDR is pivotal in treating colorectal cancer (CRC). In a previous study miR-133b was shown to be a tumor suppressor. Additionally, in CRC cells transfected with miR-133b, ATP-binding cassette (ABC) subfamily C member 1(ABCC1) was shown to be significantly down regulated. Whether miR-133b also enhances the chemosensitivity of drugs used to treat CRC by targeting ABCC1 is still unclear. Here, we utilized flow cytometry and high-performance liquid chromatography (HPLC) analysis to identify the ability of miR-133b to reserve MDR in CRC. We then used a dual-luciferase reporter assay to validate that miR-133b targets ABCC1. Further in vivo experiments were designed to validate the method in which miR-133b reversed MDR in CRC cells. The results demonstrated that the level of miR-133b was down-regulated and the expression of ABCC1 was up-regulated in drug-resistant CRC cells compared to non-drug-resistant CRC cells. The restoration of miR-133b expression in CRC drug-resistant cells in vitro resulted in reduced IC50s to chemotherapeutic drugs, significantly induced G1 accumulation, inhibited growth and promoted necrosis in combination with either 5-fluorouracil (5-FU) or vincristine (VCR), and decreased the expression of ABCC1. The dual-luciferase assay demonstrated that miR-133b directly targets ABCC1. The combination of agomiRNA-133b with chemotherapeutic drugs in vivo inhibited tumor growth induced by CRC drug-resistant cells. A xenograft from the in vivo model resulted in up-regulated levels of miR-133b and down-regulated levels of ABCC1. Therefore, miR-133b enhances the chemosensitivity of CRC cells to anti-tumor drugs by directly down-regulating ABCC1. This discovery provides a therapeutic strategy in which miR-133b is used as a potential sensitizer for drug-resistant CRC.

Bright and durable field emission source derived from refractory taylor cones

Science.gov (United States)

Hirsch, Gregory

2016-12-20

A method of producing field emitters having improved brightness and durability relying on the creation of a liquid Taylor cone from electrically conductive materials having high melting points. The method calls for melting the end of a wire substrate with a focused laser beam, while imposing a high positive potential on the material. The resulting molten Taylor cone is subsequently rapidly quenched by cessation of the laser power. Rapid quenching is facilitated in large part by radiative cooling, resulting in structures having characteristics closely matching that of the original liquid Taylor cone. Frozen Taylor cones thus obtained yield desirable tip end forms for field emission sources in electron beam applications. Regeneration of the frozen Taylor cones in-situ is readily accomplished by repeating the initial formation procedures. The high temperature liquid Taylor cones can also be employed as bright ion sources with chemical elements previously considered impractical to implement.

Survivin -31 G/C polymorphism might contribute to colorectal cancer (CRC) risk: a meta-analysis.

Science.gov (United States)

Yao, Linhua; Hu, Yi; Deng, Zhongmin; Li, Jingjing

2015-01-01

Published data has shown inconsistent findings about the association of survivin -31 G/C polymorphism with the risk of colorectal cancer (CRC). This meta-analysis quantitatively assesses the results from published studies to provide a more precise estimate of the association between survivin -31 G/C polymorphism as a possible predictor of the risk of CRC. We conducted a literature search in the PubMed, Web of Science, and Cochrane Library databases. Stata 12 software was used to calculate the pooled odds ratios (ORs) with 95% confidence intervals (CIs) based on the available data from each article. Six studies including 1840 cases with CRC and 1804 controls were included in this study. Survivin -31 G/C polymorphism was associated with a significantly increased risk of CRC (OR = 1.78; 95% CI, 1.53-2.07; I(2) = 0%). In the race subgroup analysis, both Asians (OR = 1.72; 95% CI, 1.44-2.05; I(2) = 0%) and Caucasians (OR = 1.93; 95% CI, 1.46-2.55; I(2) = 0%) with survivin -31 G/C polymorphism had increased CRC risk. In the subgroup analysis according to site of CRC, survivin -31 G/C polymorphism was not associated with colon cancer risk (OR = 2.02; 95% CI, 0.79-5.22; I(2) = 82%). However, this polymorphism was significantly associated with rectum cancer risk (OR = 1.98; 95% CI, 1.42-2.74; I(2) = 0%). In the subgroup analysis by clinical stage, both early stage (I+II) and advanced stage (III+IV) were associated with survivin -31 G/C polymorphism (OR = 1.61; 95% CI, 1.20-2.16; I(2) = 0% and OR = 2.30; 95% CI, 1.70-3.13; I(2) = 0%, respectively). In the subgroup analysis by smoke status, both smokers and non-smokers with survivin -31 G/C polymorphism showed increased CRC risk (OR = 1.47; 95% CI, 1.01-2.13; I(2) = 60% and OR = 1.71; 95% CI, 1.28-2.30; I(2) = 0%, respectively). In the subgroup analysis by drink status, both drinkers and non-drinkers with survivin -31 G/C polymorphism showed increased CRC risk (OR = 1.58; 95% CI, 1.06-2.37; I(2) = 8% and OR = 1.61; 95% CI, 1

The CRC 20 years: An overview of some of the major achievements and remaining challenges.

Science.gov (United States)

Doek, Jaap E

2009-11-01

On 20 November 1989, the General Assembly of the United Nations adopted the Convention on the Rights of the Child (CRC). It entered into force on 2 September 1990 and has by now been ratified by 193 States, making the most universally ratified human rights treaty. This overview will present and discuss the impact of this treaty both at the international and the national level, an overview which necessarily has to be limited to some of the developments as a result of the implementation of the CRC. The first part of this paper will be devoted to the impact the CRC had and still has on the setting and development of the international agenda for the promotion and protection of the rights and welfare of children. Special attention will given to developments, achievements, and remaining challenges at the international level with regard to protection of children in armed conflict; prevention and the protection of children from sexual exploitation; and from all forms of violence. This will include some information on the impact of these international developments and actions at the national level, for example, in the area of legislation. The second part will focus on the impact at the national level. Given the wide scope of the CRC this part will be limited to some of the General Measures of Implementation (law reform, national programmes, and independent monitoring) and the General Principles (non-discrimination, best interest, right to be heard) of the CRC. This will be based on reports of States on the implementation of the CRC submitted to the CRC Committee and the Concluding Observations of this Committee and on a number of studies. The conclusion will provide remarks on poverty as one of the major remaining challenges for the implementation of children's rights.

Low Complexity List Decoding for Polar Codes with Multiple CRC Codes

Directory of Open Access Journals (Sweden)

Jong-Hwan Kim

2017-04-01

Full Text Available Polar codes are the first family of error correcting codes that provably achieve the capacity of symmetric binary-input discrete memoryless channels with low complexity. Since the development of polar codes, there have been many studies to improve their finite-length performance. As a result, polar codes are now adopted as a channel code for the control channel of 5G new radio of the 3rd generation partnership project. However, the decoder implementation is one of the big practical problems and low complexity decoding has been studied. This paper addresses a low complexity successive cancellation list decoding for polar codes utilizing multiple cyclic redundancy check (CRC codes. While some research uses multiple CRC codes to reduce memory and time complexity, we consider the operational complexity of decoding, and reduce it by optimizing CRC positions in combination with a modified decoding operation. Resultingly, the proposed scheme obtains not only complexity reduction from early stopping of decoding, but also additional reduction from the reduced number of decoding paths.

Experiments on the Taylor system with an axial flow

International Nuclear Information System (INIS)

Tsameret, Avraham.

1993-02-01

This work is an experimental study of the Taylor system with a superimposed axial flow. The convective and absolute instability lines which are associated with the propagating Taylor vortices are measured. A quantitative agreement is found with the theoretical predictions. Noise-sustained structures are found to exist in the convectively unstable region, above a critical value of the through flow. These structures are propagating Taylor vortices that are characterized by a noisy power spectrum and irregular temporal dynamics of velocity amplitude. At the absolute instability line the power spectrum of the propagating Taylor vortices exhibits transition to a sharp peak, and the amplitude of the propagating Taylor vortices becomes stationary. The mechanism that generates the noise-sustained structures is identified with a process of permanent amplification of noise that is generated mainly near the inlet boundary. The intrinsic noise in the system is studied. This study is motivated by the question of whether the noise which generates the noise-sustained structures is thermal. The intensity of the intrinsic noise is estimated by several methods, which includes a comparison of data with numerical simulations of the amplitude equation with a noise term. It is found that the intrinsic noise is not thermal, although its intensity reaches the thermal noise level at small through-flow velocities. Novel states are manifested in the system as a result of interaction between the propagating Taylor vortices and spiral modes. These states are studied and their spatial and temporal properties are analyzed. (author)

Centrifugally Driven Rayleigh-Taylor Instability

Science.gov (United States)

Scase, Matthew; Hill, Richard

2017-11-01

The instability that develops at the interface between two fluids of differing density due to the rapid rotation of the system may be considered as a limit of high-rotation rate Rayleigh-Taylor instability. Previously the authors have considered the effect of rotation on a gravitationally dominated Rayleigh-Taylor instability and have shown that some growth modes of instability may be suppressed completely by the stabilizing effect of rotation (Phys. Rev. Fluids 2:024801, Sci. Rep. 5:11706). Here we consider the case of very high rotation rates and a negligible gravitational field. The initial condition is of a dense inner cylinder of fluid surrounded by a lighter layer of fluid. As the system is rotated about the generating axis of the cylinder, the dense inner fluid moves away from the axis and the familiar bubbles and spikes of Rayleigh-Taylor instability develop at the interface. The system may be thought of as a ``fluid-fluid centrifuge''. By developing a model based on an Orr-Sommerfeld equation, we consider the effects of viscosity, surface tension and interface diffusion on the growth rate and modes of instability. We show that under particular circumstances some modes may be stabilized. School of Mathematical Sciences.

Combination of preoperative NLR, PLR and CEA could increase the diagnostic efficacy for I-III stage CRC.

Science.gov (United States)

Peng, Hong-Xin; Yang, Lin; He, Bang-Shun; Pan, Yu-Qin; Ying, Hou-Qun; Sun, Hui-Ling; Lin, Kang; Hu, Xiu-Xiu; Xu, Tao; Wang, Shu-Kui

2017-09-01

Inflammation plays an important role in the development and progression of CRC. The members of inflammatory biomarkers, preoperative NLR and PLR, have been proved by numerous studies to be promising prognostic biomarkers for CRC. However, the diagnostic value of the two biomarkers in CRC remains unknown, and no study reported the combined diagnostic efficacy of NLR, PLR and CEA. Five hundred and fifty-nine patients with I-III stage CRC undergoing surgical resection and 559 gender- and age-matched healthy controls were enrolled in this retrospective study. NLR and PLR were calculated from preoperative peripheral blood cell count detected using white blood cell five classification by Sysmex XT-1800i Automated Hematology System and serum CEA were measured by electrochemiluminescence by ELECSYS 2010. The diagnostic performance of NLR, PLR and CEA for CRC was evaluated by ROC curve. Levels of NLR and PLR in the cases were significantly higher than them in the healthy controls. ROC curves comparison analyses showed that the diagnostic efficacy of NLR (AUC=.755, 95%CI=.728-.780) alone for CRC was significantly higher than PLR (AUC=.723, 95%CI=.696-.749, P=.037) and CEA (AUC=.690, 95%CI=.662-.717, P=.002) alone. In addition, the diagnostic efficacy of the combination of NLR, PLR and CEA(AUC=.831, 95%CI=.807-.852)for CRC was not only significantly higher than NLR alone but also higher than any combinations of the two of these three biomarkers (PCRC diagnostic biomarker, even for early stage CRC, and the combination of NLR, PLR and CEA could significantly improve the diagnostic efficacy. © 2016 Wiley Periodicals, Inc.

Animating Nested Taylor Polynomials to Approximate a Function

Science.gov (United States)

Mazzone, Eric F.; Piper, Bruce R.

2010-01-01

The way that Taylor polynomials approximate functions can be demonstrated by moving the center point while keeping the degree fixed. These animations are particularly nice when the Taylor polynomials do not intersect and form a nested family. We prove a result that shows when this nesting occurs. The animations can be shown in class or…

IRRIGATION PRACTICES IN LONG-TERM SURVIVORS OF COLORECTAL CANCER (CRC) WITH COLOSTOMIES

OpenAIRE

Grant, Marcia; McMullen, Carmit K.; Altschuler, Andrea; Hornbrook, Mark C.; Herrinton, Lisa J.; Wendel, Christopher S.; Baldwin, Carol M.; Krouse, Robert S.

2012-01-01

Creation of a colostomy in colorectal (CRC) cancer patients results in a loss of control over bowel evacuation. The only way to re-establish some control is through irrigation, a procedure that involves instilling fluid into the bowel to allow for gas and fecal output. This article reports on irrigation practices of participants in a large, multi-site, multi-investigator study of health-related quality of life (HR-QOL) in long term CRC survivors. Questions about irrigation practices were iden...

Influence of the Crc regulator on the hierarchical use of carbon sources from a complete medium in Pseudomonas.

Science.gov (United States)

La Rosa, Ruggero; Behrends, Volker; Williams, Huw D; Bundy, Jacob G; Rojo, Fernando

2016-03-01

The Crc protein, together with the Hfq protein, participates in catabolite repression in pseudomonads, helping to coordinate metabolism. Little is known about how Crc affects the hierarchy of metabolite assimilation from complex mixtures. Using proton Nuclear Magnetic Resonance (NMR) spectroscopy, we carried out comprehensive metabolite profiling of culture supernatants (metabolic footprinting) over the course of growth of both Pseudomonas putida and P. aeruginosa, and compared the wild-type strains with deletion mutants for crc. A complex metabolite consumption hierarchy was observed, which was broadly similar between the two species, although with some important differences, for example in sugar utilization. The order of metabolite utilization changed upon inactivation of the crc gene, but even in the Crc-null strains some compounds were completely consumed before late metabolites were taken up. This suggests the presence of additional regulatory elements that determine the time and order of consumption of compounds. Unexpectedly, the loss of Crc led both species to excrete acetate and pyruvate as a result of unbalanced growth during exponential phase, compounds that were later consumed in stationary phase. This loss of carbon during growth helps to explain the contribution of the Crc/Hfq regulatory system to evolutionary fitness of pseudomonads. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd.

NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.

Science.gov (United States)

Narayan, Satya; Jaiswal, Aruna S; Sharma, Ritika; Nawab, Akbar; Duckworth, Lizette Vila; Law, Brian K; Zajac-Kaye, Maria; George, Thomas J; Sharma, Jay; Sharma, Arun K; Hromas, Robert A

2017-08-22

The 5-fluorouracil (5-FU) treatment induces DNA damage and stalling of DNA replication forks. These stalled replication forks then collapse to form one sided double-strand breaks, leading to apoptosis. However, colorectal cancer (CRC) stem cells rapidly repair the stalled/collapsed replication forks and overcome treatment effects. Recent evidence suggests a critical role of checkpoint kinase 1 (Chk1) in preventing the replicative stress. Therefore, Chk1 kinase has been a target for developing mono or combination therapeutic agents. In the present study, we have identified a novel orphan molecule NSC30049 (NSC49L) that is effective alone, and in combination potentiates 5-FU-mediated growth inhibition of CRC heterogeneous bulk and FOLFOX-resistant cell lines in culture with minimal effect on normal colonic epithelial cells. It also inhibits the sphere forming activity of CRC stem cells, and decreases the expression levels of mRNAs of CRC stem cell marker genes. Results showed that NSC49L induces 5-FU-mediated S-phase cell cycle arrest due to increased load of DNA damage and increased γ-H2AX staining as a mechanism of cytotoxicity. The pharmacokinetic analysis showed a higher bioavailability of this compound, however, with a short plasma half-life. The drug is highly tolerated by animals with no pathological aberrations. Furthermore, NSC49L showed very potent activity in a HDTX model of CRC stem cell tumors either alone or in combination with 5-FU. Thus, NSC49L as a single agent or combined with 5-FU can be developed as a therapeutic agent by targeting the Chk1 pathway in 5-FU-resistant CRC heterogeneous bulk and CRC stem cell populations.

Instabilities with polyacrylamide solution in small and large aspect ratios Taylor-Couette systems

International Nuclear Information System (INIS)

Smieszek, M; Egbers, C; Crumeyrolle, O; Mutabazi, I

2008-01-01

We have investigated the stability of viscoelastic polyacrylamide solution in Taylor-Couette system with different aspect ratios. The first instability modes observed in a Taylor-Couette system with Γ = 10 were TVF and WVF, as for Newtonian fluid. At higher Taylor numbers moving vortices occur, a wavy mode with non-stationary vortex size. In the Taylor-Couette system with Γ = 45.9 we note a coexistence of various instability modes. In addition to TVF, counterpropagating waves developed at the transition from the base state flow. At higher Taylor number values Taylor vortices of different sizes occurred. Reduced amplitude Wavy vortex flow has also been observed.

CRC Credential Attainment by State Vocational Rehabilitation Counselors

Science.gov (United States)

Harpster, Anna M.; Byers, Katherine L.; Harris, LaKeisha L.

2011-01-01

This study examines 137 state vocational rehabilitation (VR) counselors' perceptions of the value of having the Certified Rehabilitation Counselor (CRC) credential. While almost 53% of this sample included persons who were certified, the majority who were not indicated that the two major reasons for not currently having this designation were: (a)…

Repainting, modifying, smashing Taylorism

NARCIS (Netherlands)

H.D. Pruijt (Hans)

2000-01-01

textabstractAbstract Survey data show that post-Tayloristic production concepts are not developing to the extent that many researchers had originally expected. It also is inadequate to portray post-Taylorism as a development that is happening, but just slower than expected. This is inadequate

Rayleigh-Taylor instability and mixing in SN 1987A

International Nuclear Information System (INIS)

Ebisuzaki, T.; Shigeyama, T.; Nomoto, K.

1989-01-01

The stability of the supernova ejecta is compared with the Rayleigh-Taylor instability for a realistic model of SN 1987A. A linear analysis indicates that the layers around the composition interface between the hydrogen-rich and helium zones, and become Rayleigh-Taylor unstable between the helium and metal zones. In these layers, the pressure increases outward because of deceleration due to the reverse shock which forms when the blast shock hits the massive hydrogen-rich envelope. On the contrary, the density steeply decreases outward because of the preexisting nuclear burning shell. Then, these layers undergo the Raleigh-Taylor instability because of the opposite signs of the pressure and density gradients. The estimated growth rate is larger than the expansion rate of the supernova. The Rayleigh-Taylor instability near the composition interface is likely to induce mixing, which has been strongly suggested from observations of SN 1987A. 25 refs

Dynamics of helicity transport and Taylor relaxation

International Nuclear Information System (INIS)

Diamond, P.H.; Malkov, M.

2003-01-01

A simple model of the dynamics of Taylor relaxation is derived using symmetry principles alone. No statistical closure approximations are invoked or detailed plasma model properties assumed. Notably, the model predicts several classes of nondiffusive helicity transport phenomena, including traveling nonlinear waves and superdiffusive turbulent pulses. A universal expression for the scaling of the effective magnetic Reynolds number of a system undergoing Taylor relaxation is derived. Some basic properties of intermittency in helicity transport are examined

Structural stability, electronic, mechanical and superconducting properties of CrC and MoC

Energy Technology Data Exchange (ETDEWEB)

Kavitha, M.; Sudha Priyanga, G. [Department of Physics, N.M.S.S.V.N College, Madurai 625019, Tamilnadu (India); Rajeswarapalanichamy, R., E-mail: rrpalanichamy@gmail.com [Department of Physics, N.M.S.S.V.N College, Madurai 625019, Tamilnadu (India); Iyakutti, K. [Department of Physics and Nanotechnology, SRM University, Chennai 603203, Tamilnadu (India)

2016-02-01

The structural, electronic, mechanical and superconducting properties of chromium carbide (CrC) and molybdenum carbide (MoC) are investigated using first principles calculations based on density functional theory (DFT). The computed ground state properties like equilibrium lattice constants and cell volume are in good agreement with available theoretical and experimental data. A pressure induced structural phase transition from tungsten carbide phase (WC) to zinc blende phase (ZB) and then zinc blende phase (ZB) to nickel arsenide phase (NiAs) are observed in both chromium and molybdenum carbides. Electronic structure reveals that these carbides are metallic at ambient condition. All the calculated elastic constants obey the Born–Huang stability criteria, suggesting that they are mechanically stable at normal and high pressure. The super conducting transition temperatures for CrC and MoC in WC phase are found to be 31.12 K and 17.14 K respectively at normal pressure. - Highlights: • Electronic and mechanical properties of CrC and MoC are investigated. • Pressure induced structural phase transition is predicted at high pressure. • Electronic structure reveals that these materials exhibit metallic behaviour. • Debye temperature values are computed for CrC and MoC. • Superconducting transition temperature values are computed.

High Speed Solution of Spacecraft Trajectory Problems Using Taylor Series Integration

Science.gov (United States)

Scott, James R.; Martini, Michael C.

2008-01-01

Taylor series integration is implemented in a spacecraft trajectory analysis code-the Spacecraft N-body Analysis Program (SNAP) - and compared with the code s existing eighth-order Runge-Kutta Fehlberg time integration scheme. Nine trajectory problems, including near Earth, lunar, Mars and Europa missions, are analyzed. Head-to-head comparison at five different error tolerances shows that, on average, Taylor series is faster than Runge-Kutta Fehlberg by a factor of 15.8. Results further show that Taylor series has superior convergence properties. Taylor series integration proves that it can provide rapid, highly accurate solutions to spacecraft trajectory problems.

Vortex formation in Taylor-Couette flow with weakly spatial modulation

International Nuclear Information System (INIS)

Li, Z.; Khayat, R.E.

2002-01-01

The onset of the vortex structure in axisymmetric Taylor-Couette flow with spatially modulated cylinders is examined. The modulation amplitude is assumed to be small for a regular perturbation solution to be sought at small to moderate Taylor numbers. It is found that the presence of a weak modulation of the outer or inner cylinders leads unavoidably to the emergence of steady vortex flow even for a vanishingly small Taylor number. This situation is reminiscent of the onset of an imperfect bifurcation. The vortex structure of the forced TVF is found to have same periodicity when only one cylinder is modulated or the two modulations are commensurate for the Taylor number measured. The vortex structure is quasi-periodic when the two modulations are incommensurate. For a certain Taylor number, there exists a critical wavelength for the presence of the strongest vortex flow when the modulation is in the form of sinusoidal. This critical wavelength tends to the critical value predicted by the linear stability analysis when Ta approaches the supercritical value. (author)

Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H).

Science.gov (United States)

Goldstein, J; Tran, B; Ensor, J; Gibbs, P; Wong, H L; Wong, S F; Vilar, E; Tie, J; Broaddus, R; Kopetz, S; Desai, J; Overman, M J

2014-05-01

The microsatellite instability-high (MSI-H) phenotype, present in 15% of early colorectal cancer (CRC), confers good prognosis. MSI-H metastatic CRC is rare and its impact on outcomes is unknown. We describe survival outcomes and the impact of chemotherapy, metastatectomy, and BRAF V600E mutation status in the largest reported cohort of MSI-H metastatic colorectal cancer (CRC). A retrospective review of 55 MSI-H metastatic CRC patients from two institutions, Royal Melbourne Hospital (Australia) and The University of Texas MD Anderson Cancer Center (United States), was conducted. Statistical analyses utilized Kaplan-Meier method, Log-rank test, and Cox proportional hazards models. Median age was 67 years (20-90), 58% had poor differentiation, and 45% had stage IV disease at presentation. Median overall survival (OS) from metastatic disease was 15.4 months. Thirteen patients underwent R0/R1 metastatectomies, with median OS from metastatectomy 33.8 months. Thirty-one patients received first-line systemic chemotherapy for metastatic disease with median OS from the start of chemotherapy 11.5 months. No statistically significant difference in progression-free survival or OS was seen between fluoropyrimidine, oxaliplatin, or irinotecan based chemotherapy. BRAF V600E mutation was present in 14 of 47 patients (30%). BRAF V600E patients demonstrated significantly worse median OS; 10.1 versus 17.3 months, P = 0.03. In multivariate analyses, BRAF V600E mutants had worse OS (HR 4.04; P = 0.005), while patients undergoing metastatectomy (HR 0.11; P = CRC do not appear to have improved outcomes. BRAF V600E mutation is a poor prognostic factor in MSI-H metastatic CRC.

A design of inverse Taylor projectiles using material simulation

International Nuclear Information System (INIS)

Tonks, Michael; Harstad, Eric; Maudlin, Paul; Trujillo, Carl

2008-01-01

The classic Taylor cylinder test, in which a right circular cylinder is projected at a rigid anvil, exploits the inertia of the projectile to access strain rates that are difficult to achieve with more traditional uniaxial testing methods. In this work we present our efforts to design inverse Taylor projectiles, in which a tapered projectile becomes a right circular cylinder after impact, from annealed copper and show that the self-correcting geometry leads to a uniform compressive strain in the radial direction. We design projectiles using finite element simulation and optimization that deform as desired in tests with minor deviations in the deformed geometry due to manufacturing error and uncertainty in the initial velocity. The inverse Taylor projectiles designed in this manner provide a simple means of validating constitutive models. This work is a step towards developing a general method of designing Taylor projectiles that provide stress–strain behavior relevant to particular engineering problems

Techniques for optimizing nanotips derived from frozen taylor cones

Science.gov (United States)

Hirsch, Gregory

2017-12-05

Optimization techniques are disclosed for producing sharp and stable tips/nanotips relying on liquid Taylor cones created from electrically conductive materials with high melting points. A wire substrate of such a material with a preform end in the shape of a regular or concave cone, is first melted with a focused laser beam. Under the influence of a high positive potential, a Taylor cone in a liquid/molten state is formed at that end. The cone is then quenched upon cessation of the laser power, thus freezing the Taylor cone. The tip of the frozen Taylor cone is reheated by the laser to allow its precise localized melting and shaping. Tips thus obtained yield desirable end-forms suitable as electron field emission sources for a variety of applications. In-situ regeneration of the tip is readily accomplished. These tips can also be employed as regenerable bright ion sources using field ionization/desorption of introduced chemical species.

PREFACE: The 15th International Couette-Taylor Worskhop

Science.gov (United States)

Mutabazi, Innocent; Crumeyrolle, Olivier

2008-07-01

The 15th International Couette-Taylor Worskhop (ICTW15) was held in Le Havre, France from 9-12 July 2007. This regular international conference started in 1979 in Leeds, UK when the research interest in simple models of fluid flows was revitalized by systematic investigation of Rayleigh-Bénard convection and the Couette-Taylor flow. These two flow systems are good prototypes for the study of the transition to chaos and turbulence in closed flows. The workshop themes have been expanded from the original Couette-Taylor flow to include other centrifugal instabilities (Dean, Görtler, Taylor-Dean), spherical Couette flows, thermal convection instabilities, MHD, nonlinear dynamics and chaos, transition to turbulence, development of numerical and experimental techniques. The impressive longevity of the ICTW is due to the close interaction and fertile exchanges between international research groups from different disciplines: Physics and Astrophysics, Applied Mathematics, Mechanical Engineering, Chemical Engineering. The present workshop was attended by 100 participants, the program included over 83 contributions with 4 plenary lectures, 68 oral communications and 17 posters. The topics include, besides the classical Couette-Taylor flows, the centrifugal flows with longitudinal vortices, the shear flows, the thermal convection in curved geometries, the spherical Couette-Taylor flow, the geophysical flows, the magneto-hydrodynamic effects including the dynamo effect, the complex flows (viscoelasticity, immiscible fluids, bubbles and migration). Selected papers have been processed through the peer review system and are published in this issue of the Journal of Physics: Conference Series. The Workshop has been sponsored by Le Havre University, the Region Council of Haute-Normandie, Le Havre City Council, CNRS (ST2I, GdR-DYCOEC), and the European Space Agency through GEOFLOW program. The French Ministry of Defense (DGA), the Ministry of Foreign Affairs, the Ministry of

DSM-5 and ADHD - an interview with Eric Taylor.

Science.gov (United States)

Taylor, Eric

2013-09-12

In this podcast we talk to Prof Eric Taylor about the changes to the diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) in DSM-5 and how these changes will affect clinical practice. The podcast for this interview is available at: http://www.biomedcentral.com/sites/2999/download/Taylor.mp3.

Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24.

Science.gov (United States)

Ishimaru, Shinya; Mimori, Koshi; Yamamoto, Ken; Inoue, Hiroshi; Imoto, Seiya; Kawano, Shuichi; Yamaguchi, Rui; Sato, Tetsuya; Toh, Hiroyuki; Iinuma, Hisae; Maeda, Toyoki; Ishii, Hideshi; Suzuki, Sadao; Tokudome, Shinkan; Watanabe, Masahiko; Tanaka, Jun-ichi; Kudo, Shin-ei; Sugihara, Ken-ichi; Hase, Kazuo; Mochizuki, Hidetaka; Kusunoki, Masato; Yamada, Kazutaka; Shimada, Yasuhiro; Moriya, Yoshihiro; Barnard, Graham F; Miyano, Satoru; Mori, Masaki

2012-09-01

Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulin-dependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.

Disease severity does not affect the interval between IBD diagnosis and the development of CRC: results from two large, Dutch case series.

Science.gov (United States)

Mooiweer, Erik; Baars, Judith E; Lutgens, Maurice W M D; Vleggaar, Frank; van Oijen, Martijn; Siersema, Peter D; Kuipers, Ernst J; van der Woude, C Janneke; Oldenburg, Bas

2012-05-01

The increased risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) is well established. The incidence of IBD-related CRC however, differs markedly between cohorts from referral centers and population-based studies. In the present study we aimed to identify characteristics potentially explaining these differences in two cohorts of patients with IBD-related CRC. PALGA, a nationwide pathology network and registry in The Netherlands, was used to search for patients with IBD-associated CRC between 1990 and 2006. Patients from 7 referral hospitals and 78 general hospitals were included. Demographic and disease specific parameters were collected retrospectively using patient charts. A total of 281 patients with IBD-associated CRC were identified. Patients from referral hospitals had a lower median age at IBD diagnosis (26 years vs. 28 years (p=0.02)), while having more IBD-relapses before CRC diagnosis than patients from general hospitals (3.8 vs. 1.5 (pCRC was diagnosed at a younger age (47 years vs. 51 years (p=0.01)). However, the median interval between IBD diagnosis and diagnosis of CRC was similar in both cohorts (19 years in referral hospitals vs. 17 years in general hospitals (p=0.13)). IBD patients diagnosed with CRC treated in referral hospitals in The Netherlands are younger at both the diagnosis of IBD and CRC than IBD patients with CRC treated in general hospitals. Although patients from referral centers appeared to have a more severe course of IBD, the interval between IBD and CRC diagnosis was similar. Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

Conditionally reprogrammed cells (CRC) methodology does not allow the in vitro expansion of patient-derived primary and metastatic lung cancer cells.

Science.gov (United States)

Sette, Giovanni; Salvati, Valentina; Giordani, Ilenia; Pilozzi, Emanuela; Quacquarini, Denise; Duranti, Enrico; De Nicola, Francesca; Pallocca, Matteo; Fanciulli, Maurizio; Falchi, Mario; Pallini, Roberto; De Maria, Ruggero; Eramo, Adriana

2018-07-01

Availability of tumor and non-tumor patient-derived models would promote the development of more effective therapeutics for non-small cell lung cancer (NSCLC). Recently, conditionally reprogrammed cells (CRC) methodology demonstrated exceptional potential for the expansion of epithelial cells from patient tissues. However, the possibility to expand patient-derived lung cancer cells using CRC protocols is controversial. Here, we used CRC approach to expand cells from non-tumoral and tumor biopsies of patients with primary or metastatic NSCLC as well as pulmonary metastases of colorectal or breast cancers. CRC cultures were obtained from both tumor and non-malignant tissues with extraordinary high efficiency. Tumor cells were tracked in vitro through tumorigenicity assay, monitoring of tumor-specific genetic alterations and marker expression. Cultures were composed of EpCAM+ lung epithelial cells lacking tumorigenic potential. NSCLC biopsies-derived cultures rapidly lost patient-specific genetic mutations or tumor antigens. Similarly, pulmonary metastases of colon or breast cancer generated CRC cultures of lung epithelial cells. All CRC cultures examined displayed epithelial lung stem cell phenotype and function. In contrast, brain metastatic lung cancer biopsies failed to generate CRC cultures. In conclusion, patient-derived primary and metastatic lung cancer cells were negatively selected under CRC conditions, limiting the expansion to non-malignant lung epithelial stem cells from either tumor or non-tumor tissue sources. Thus, CRC approach cannot be applied for direct therapeutic testing of patient lung tumor cells, as the tumor-derived CRC cultures are composed of (non-tumoral) airway basal cells. © 2018 UICC.

Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: a systematic review and meta-analysis.

Science.gov (United States)

Li, Rui; Liu, Jianjun; Xue, Huiping; Huang, Gang

2012-10-15

The measurement of fecal tumor M2-pyruvate kinase (PKM2), overexpressed in tumor cells, has been proposed as a novel tool for detecting colorectal cancer (CRC). However, the sensitivity and specificity of this test varied among studies. The aim of this meta-analysis was to determine the diagnostic accuracy of fecal PKM2 for CRC and to evaluate its utility in the CRC screening. It was compared to guaiac fecal occult blood test (gFOBT) or immunological fecal occult blood test (iFOBT). Through comprehensive literature search, 10 studies met the inclusion criteria and were included. Summary estimates for sensitivity and specificity were calculated by using the bivariate random effect model. The hierarchical summary receiver operating characteristic curve was also undertaken. The overall sensitivity and specificity of fecal PKM2 for detecting CRC were 79% (95% CI = 75-83%) and 81% (95% CI = 73-87%), respectively. The summary positive predictive value and negative predictive value were 74% (95% CI = 56-87%) and 86% (95% CI = 79-91%), respectively. The pooled diagnostic odds ratio was 16 (95% CI = 10-26). In head-to-head comparison, the diagnostic odds ratio of PKM2 and gFOBT for CRC were 10.167 (95% CI = 5.992-17.250) and 6.557 (95% CI = 3.467-12.403), respectively. The diagnostic odds ratio of PKM2 and iFOBT for CRC were 9.542 (95% CI = 5.893-15.452) and 67.248 (95% CI = 16.194-279.26), respectively. The fecal PKM2 test was a diagnostic tool with moderate sensitivity and specificity for detecting CRC. Its diagnostic efficiency was similar to that of gFOBT. Because of its relatively low specificity and positive predict value, fecal PKM2 was not recommended used alone as a screening tool for CRC. Copyright © 2012 UICC.

Compression of an Accelerated Taylor State in SSX

Science.gov (United States)

Shrock, J. E.; Suen-Lewis, E. M.; Barbano, L. J.; Kaur, M.; Schaffner, D. A.; Brown, M. R.

2017-10-01

In the Swarthmore Spheromak Experiment (SSX), compact toroidal plasmas are launched from a plasma gun and evolve into minimum energy twisted Taylor states. The plumes initially have a velocity 40 km/s, density 0.4 ×1016 cm-3 , and proton temperature 20 eV . After formation, the plumes are accelerated by pulsed pinch coils with rise times τ1 / 4 = (π / 2) √{ LC } less than 1 μ s and currents Ipeak =V0 / Z =V0 /√{ L / C } on the order of 104 A. The accelerated Taylor States are abruptly stagnated in a copper flux conserver, and over the course of t plasma, the other to particle motion parallel to the field. We observe Taylor state compression most in agreement with the parallel equation of state: d / dt (P∥B2 /n3) = 0 . DOE ARPA-E ALPHA Program.

Nonlinear saturation of the Rayleigh endash Taylor instability

International Nuclear Information System (INIS)

Das, A.; Mahajan, S.; Kaw, P.; Sen, A.; Benkadda, S.; Verga, A.

1997-01-01

A detailed numerical simulation of the nonlinear state of the Rayleigh endash Taylor instability has been carried out. There are three distinct phases of evolution where it is governed by the (i) linear effects, (ii) effects arising from the conventional nonlinear terms and (iii) subtle nonlinear effects arising through the coupling terms. During the third phase of evolution, there is a self-consistent generation of shear flow which saturates the Rayleigh endash Taylor instability even in situations (with periodic boundaries) where, in principle, an infinite amount of gravitational energy can be tapped. The Galerkin approximation is presented to provide an understanding of our numerical findings. Last, there is an attempt to provide a comprehensive understanding of the nonlinear state of the Rayleigh endash Taylor instability by comparing and contrasting this work with earlier studies. copyright 1997 American Institute of Physics

On Using Taylor's Hypothesis for Three-Dimensional Mixing Layers

Science.gov (United States)

LeBoeuf, Richard L.; Mehta, Rabindra D.

1995-01-01

In the present study, errors in using Taylor's hypothesis to transform measurements obtained in a temporal (or phase) frame onto a spatial one were evaluated. For the first time, phase-averaged ('real') spanwise and streamwise vorticity data measured on a three-dimensional grid were compared directly to those obtained using Taylor's hypothesis. The results show that even the qualitative features of the spanwise and streamwise vorticity distributions given by the two techniques can be very different. This is particularly true in the region of the spanwise roller pairing. The phase-averaged spanwise and streamwise peak vorticity levels given by Taylor's hypothesis are typically lower (by up to 40%) compared to the real measurements.

Shapes of an Air Taylor Bubble in Stagnant Liquids Influenced by Different Surface Tensions

Science.gov (United States)

Lertnuwat, B.

2018-02-01

The aim of this work is to propose an empirical model for predicting shapes of a Taylor bubble, which is a part of slug flows, under different values of the surface tension in stagnant liquids by employing numerical simulations. The k - Ɛ turbulence model was used in the framework of finite volume method for simulating flow fields in a unit of slug flow and also the pressure distribution on a Taylor bubble surface. Assuming that an air pressure distribution inside the Taylor bubble must be uniform, a grid search method was exploited to find an appropriate shape of a Taylor bubble for six values of surface tension. It was found that the shape of a Taylor bubble would be blunter if the surface tension was increased. This was because the surface tension affected the Froude number, controlling the flow around a Taylor bubble. The simulation results were also compared with the Taylor bubble shape, created by the Dumitrescu-and-Taylor model and former studies in order to ensure that they were consistent. Finally, the empirical model was presented from the simulation results.

Co-expression analysis identifies CRC and AP1 the regulator of Arabidopsis fatty acid biosynthesis.

Science.gov (United States)

Han, Xinxin; Yin, Linlin; Xue, Hongwei

2012-07-01

Fatty acids (FAs) play crucial rules in signal transduction and plant development, however, the regulation of FA metabolism is still poorly understood. To study the relevant regulatory network, fifty-eight FA biosynthesis genes including de novo synthases, desaturases and elongases were selected as "guide genes" to construct the co-expression network. Calculation of the correlation between all Arabidopsis thaliana (L.) genes with each guide gene by Arabidopsis co-expression dating mining tools (ACT) identifies 797 candidate FA-correlated genes. Gene ontology (GO) analysis of these co-expressed genes showed they are tightly correlated to photosynthesis and carbohydrate metabolism, and function in many processes. Interestingly, 63 transcription factors (TFs) were identified as candidate FA biosynthesis regulators and 8 TF families are enriched. Two TF genes, CRC and AP1, both correlating with 8 FA guide genes, were further characterized. Analyses of the ap1 and crc mutant showed the altered total FA composition of mature seeds. The contents of palmitoleic acid, stearic acid, arachidic acid and eicosadienoic acid are decreased, whereas that of oleic acid is increased in ap1 and crc seeds, which is consistent with the qRT-PCR analysis revealing the suppressed expression of the corresponding guide genes. In addition, yeast one-hybrid analysis and electrophoretic mobility shift assay (EMSA) revealed that CRC can bind to the promoter regions of KCS7 and KCS15, indicating that CRC may directly regulate FA biosynthesis. © 2012 Institute of Botany, Chinese Academy of Sciences.

Preliminary study of Rayleigh-Taylor instability in wire-array Z-pinch

International Nuclear Information System (INIS)

He Kaihui; Feng Kaiming; Li Qiang; Gao Chunming

2000-01-01

It is important to research into the MHD Rayleigh-Taylor instability developed in Z-pinch implosion. A snowplough model of the single wire Z-pinch is presented. The perturbation amplitude of Rayleigh-Taylor instability in the wire-array Z-pinch is analyzed quantitatively. Sheared axial flow is put forward to mitigate and reduce the Rayleigh-Taylor instability. And other approaches used to mitigate MHD instability in such a super-fast process are explored

An algorithm for symplectic implicit Taylor-map tracking

International Nuclear Information System (INIS)

Yan, Y.; Channell, P.; Syphers, M.

1992-10-01

An algorithm has been developed for converting an ''order-by-order symplectic'' Taylor map that is truncated to an arbitrary order (thus not exactly symplectic) into a Courant-Snyder matrix and a symplectic implicit Taylor map for symplectic tracking. This algorithm is implemented using differential algebras, and it is numerically stable and fast. Thus, lifetime charged-particle tracking for large hadron colliders, such as the Superconducting Super Collider, is now made possible

78 FR 12307 - Taylor, G. Tom; Notice of Filing

Science.gov (United States)

2013-02-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-5705-001] Taylor, G. Tom; Notice of Filing Take notice that on February 14, 2013, G. Tom Taylor filed an application to hold interlocking positions pursuant to section 305(b) of the Federal Power Act, 16 U.S.C. 825d(b), Part 45 of the...

Taylor dispersion of nanoparticles

Science.gov (United States)

Balog, Sandor; Urban, Dominic A.; Milosevic, Ana M.; Crippa, Federica; Rothen-Rutishauser, Barbara; Petri-Fink, Alke

2017-08-01

The ability to detect and accurately characterize particles is required by many fields of nanotechnology, including materials science, nanotoxicology, and nanomedicine. Among the most relevant physicochemical properties of nanoparticles, size and the related surface-to-volume ratio are fundamental ones. Taylor dispersion combines three independent phenomena to determine particle size: optical extinction, translational diffusion, and sheer-enhanced dispersion of nanoparticles subjected to a steady laminar flow. The interplay of these defines the apparent size. Considering that particles in fact are never truly uniform nor monodisperse, we rigorously address particle polydispersity and calculate the apparent particle size measured by Taylor dispersion analysis. We conducted case studies addressing aqueous suspensions of model particles and large-scale-produced "industrial" particles of both academic and commercial interest of various core materials and sizes, ranging from 15 to 100 nm. A comparison with particle sizes determined by transmission electron microscopy confirms that our approach is model-independent, non-parametric, and of general validity that provides an accurate account of size polydispersity—independently on the shape of the size distribution and without any assumption required a priori.

Electrochemical Analysis of Taylor Vortices.

Czech Academy of Sciences Publication Activity Database

Wouahbi, F.; Allaf, K.; Sobolík, Václav

2007-01-01

Roč. 37, 1 (2007) , s. 57-62 ISSN 0021-891X Institutional research plan: CEZ:AV0Z40720504 Keywords : electrodiffusion method * taylor vortices * three-segment electrode Subject RIV: CI - Industrial Chemistry, Chemical Engineering Impact factor: 1.417, year: 2007

Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC.

Science.gov (United States)

Scarpa, Marco; Scarpa, Melania; Castagliuolo, Ignazio; Erroi, Francesca; Kotsafti, Andromachi; Basato, Silvia; Brun, Paola; D'Incà, Renata; Rugge, Massimo; Angriman, Imerio; Castoro, Carlo

2016-03-01

BACKGROUND PROMOTER: hypermethylation plays a major role in cancer through transcriptional silencing of critical genes. The aim of our study is to evaluate the methylation status of these genes in the colonic mucosa without dysplasia or adenocarcinoma at the different steps of sporadic and UC-related carcinogenesis and to investigate the possible role of genomic methylation as a marker of CRC. The expression of Dnmts 1 and 3A was significantly increased in UC-related carcinogenesis compared to non inflammatory colorectal carcinogenesis. In non-neoplastic colonic mucosa, the number of methylated genes resulted significantly higher in patients with CRC and in those with UC-related CRC compared to the HC and UC patients and patients with dysplastic lesion of the colon. The number of methylated genes in non-neoplastic colonic mucosa predicted the presence of CRC with good accuracy either in non inflammatory and inflammatory related CRC. Colonic mucosal samples were collected from healthy subjects (HC) (n = 30) and from patients with ulcerative colitis (UC) (n = 29), UC and dysplasia (n = 14), UC and cancer (n = 10), dysplastic adenoma (n = 14), and colon adenocarcinoma (n = 10). DNA methyltransferases-1, -3a, -3b, mRNA expression were quantified by real time qRT-PCR. The methylation status of CDH13, APC, MLH1, MGMT1 and RUNX3 gene promoters was assessed by methylation-specific PCR. Methylation status of APC, CDH13, MGMT, MLH1 and RUNX3 in the non-neoplastic mucosa may be used as a marker of CRC: these preliminary results could allow for the adjustment of a patient's surveillance interval and to select UC patients who should undergo intensive surveillance.

An endogenous Taylor condition in an endogenous growth monetary policy model

OpenAIRE

Le, Mai Vo; Gillman, Max; Minford, Patrick

2007-01-01

The paper derives a Taylor condition as part of the agent's equilibrium behavior in an endogenous growth monetary economy. It shows the assumptions necessary to make it almost identical to the original Taylor rule, and that it can interchangably take a money supply growth rate form. From the money supply form, simple policy experiments are conducted. A full central bank policy model is derived that includes the Taylor condition along with equations comparable to the standard aggregate-demand/...

New phenomena in variable-density Rayleigh-Taylor turbulence

Energy Technology Data Exchange (ETDEWEB)

Livescu, D; Ristorcelli, J R; Petersen, M R; Gore, R A, E-mail: livescu@lanl.gov [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

2010-12-15

This paper presents several issues related to mixing and turbulence structure in buoyancy-driven turbulence at low to moderate Atwood numbers, A, found from direct numerical simulations in two configurations: classical Rayleigh-Taylor instability and an idealized triply periodic Rayleigh-Taylor flow. Simulations at A up to 0.5 are used to examine the turbulence characteristics and contrast them with those obtained close to the Boussinesq approximation. The data sets used represent the largest simulations to date in each configuration. One of the more remarkable issues explored, first reported in (Livescu and Ristorcelli 2008 J. Fluid Mech. 605 145-80), is the marked difference in mixing between different density fluids as opposed to the mixing that occurs between fluids of commensurate densities, corresponding to the Boussinesq approximation. Thus, in the triply periodic configuration and the non-Boussinesq case, an initially symmetric density probability density function becomes skewed, showing that the mixing is asymmetric, with pure heavy fluid mixing more slowly than pure light fluid. A mechanism producing the mixing asymmetry is proposed and the consequences for the classical Rayleigh-Taylor configuration are discussed. In addition, it is shown that anomalous small-scale anisotropy found in the homogeneous configuration (Livescu and Ristorcelli 2008 J. Fluid Mech. 605 145-80) and Rayleigh-Taylor turbulence at A=0.5 (Livescu et al 2008 J. Turbul. 10 1-32) also occurs near the Boussinesq limit. Results pertaining to the moment closure modelling of Rayleigh-Taylor turbulence are also presented. Although the Rayleigh-Taylor mixing layer width reaches self-similar growth relatively fast, the lower-order terms in the self-similar expressions for turbulence moments have long-lasting effects and derived quantities, such as the turbulent Reynolds number, are slow to follow the self-similar predictions. Since eddy diffusivity in the popular gradient transport hypothesis

Prediction of Pressing Quality for Press-Fit Assembly Based on Press-Fit Curve and Maximum Press-Mounting Force

Directory of Open Access Journals (Sweden)

Bo You

2015-01-01

Full Text Available In order to predict pressing quality of precision press-fit assembly, press-fit curves and maximum press-mounting force of press-fit assemblies were investigated by finite element analysis (FEA. The analysis was based on a 3D Solidworks model using the real dimensions of the microparts and the subsequent FEA model that was built using ANSYS Workbench. The press-fit process could thus be simulated on the basis of static structure analysis. To verify the FEA results, experiments were carried out using a press-mounting apparatus. The results show that the press-fit curves obtained by FEA agree closely with the curves obtained using the experimental method. In addition, the maximum press-mounting force calculated by FEA agrees with that obtained by the experimental method, with the maximum deviation being 4.6%, a value that can be tolerated. The comparison shows that the press-fit curve and max press-mounting force calculated by FEA can be used for predicting the pressing quality during precision press-fit assembly.

Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria

Directory of Open Access Journals (Sweden)

O'Gara Fergal

2010-11-01

Full Text Available Abstract Background Catabolite repression control (CRC is an important global control system in Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a range of different environments. The mechanism of CRC in Pseudomonas spp. centres on the binding of a protein, Crc, to an A-rich motif on the 5' end of an mRNA resulting in translational down-regulation of target genes. Despite the identification of several Crc targets in Pseudomonas spp. the Crc regulon has remained largely unexplored. Results In order to predict direct targets of Crc, we used a bioinformatics approach based on detection of A-rich motifs near the initiation of translation of all protein-encoding genes in twelve fully sequenced Pseudomonas genomes. As expected, our data predict that genes related to the utilisation of less preferred nutrients, such as some carbohydrates, nitrogen sources and aromatic carbon compounds are targets of Crc. A general trend in this analysis is that the regulation of transporters is conserved across species whereas regulation of specific enzymatic steps or transcriptional activators are often conserved only within a species. Interestingly, some nucleoid associated proteins (NAPs such as HU and IHF are predicted to be regulated by Crc. This finding indicates a possible role of Crc in indirect control over a subset of genes that depend on the DNA bending properties of NAPs for expression or repression. Finally, some virulence traits such as alginate and rhamnolipid production also appear to be regulated by Crc, which links nutritional status cues with the regulation of virulence traits. Conclusions Catabolite repression control regulates a broad spectrum of genes in Pseudomonas. Some targets are genus-wide and are typically related to central metabolism, whereas other targets are species-specific, or even unique to particular strains. Further study of these novel targets will enhance our understanding of how Pseudomonas

Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria.

Science.gov (United States)

Browne, Patrick; Barret, Matthieu; O'Gara, Fergal; Morrissey, John P

2010-11-25

Catabolite repression control (CRC) is an important global control system in Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a range of different environments. The mechanism of CRC in Pseudomonas spp. centres on the binding of a protein, Crc, to an A-rich motif on the 5' end of an mRNA resulting in translational down-regulation of target genes. Despite the identification of several Crc targets in Pseudomonas spp. the Crc regulon has remained largely unexplored. In order to predict direct targets of Crc, we used a bioinformatics approach based on detection of A-rich motifs near the initiation of translation of all protein-encoding genes in twelve fully sequenced Pseudomonas genomes. As expected, our data predict that genes related to the utilisation of less preferred nutrients, such as some carbohydrates, nitrogen sources and aromatic carbon compounds are targets of Crc. A general trend in this analysis is that the regulation of transporters is conserved across species whereas regulation of specific enzymatic steps or transcriptional activators are often conserved only within a species. Interestingly, some nucleoid associated proteins (NAPs) such as HU and IHF are predicted to be regulated by Crc. This finding indicates a possible role of Crc in indirect control over a subset of genes that depend on the DNA bending properties of NAPs for expression or repression. Finally, some virulence traits such as alginate and rhamnolipid production also appear to be regulated by Crc, which links nutritional status cues with the regulation of virulence traits. Catabolite repression control regulates a broad spectrum of genes in Pseudomonas. Some targets are genus-wide and are typically related to central metabolism, whereas other targets are species-specific, or even unique to particular strains. Further study of these novel targets will enhance our understanding of how Pseudomonas bacteria integrate nutritional status cues with the regulation

Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria

LENUS (Irish Health Repository)

Browne, Patrick

2010-11-25

Abstract Background Catabolite repression control (CRC) is an important global control system in Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a range of different environments. The mechanism of CRC in Pseudomonas spp. centres on the binding of a protein, Crc, to an A-rich motif on the 5\\' end of an mRNA resulting in translational down-regulation of target genes. Despite the identification of several Crc targets in Pseudomonas spp. the Crc regulon has remained largely unexplored. Results In order to predict direct targets of Crc, we used a bioinformatics approach based on detection of A-rich motifs near the initiation of translation of all protein-encoding genes in twelve fully sequenced Pseudomonas genomes. As expected, our data predict that genes related to the utilisation of less preferred nutrients, such as some carbohydrates, nitrogen sources and aromatic carbon compounds are targets of Crc. A general trend in this analysis is that the regulation of transporters is conserved across species whereas regulation of specific enzymatic steps or transcriptional activators are often conserved only within a species. Interestingly, some nucleoid associated proteins (NAPs) such as HU and IHF are predicted to be regulated by Crc. This finding indicates a possible role of Crc in indirect control over a subset of genes that depend on the DNA bending properties of NAPs for expression or repression. Finally, some virulence traits such as alginate and rhamnolipid production also appear to be regulated by Crc, which links nutritional status cues with the regulation of virulence traits. Conclusions Catabolite repression control regulates a broad spectrum of genes in Pseudomonas. Some targets are genus-wide and are typically related to central metabolism, whereas other targets are species-specific, or even unique to particular strains. Further study of these novel targets will enhance our understanding of how Pseudomonas bacteria integrate

Aberrant methylation of GCNT2 is tightly related to lymph node metastasis of primary CRC.

Science.gov (United States)

Nakamura, Kazunori; Yamashita, Keishi; Sawaki, Hiromichi; Waraya, Mina; Katoh, Hiroshi; Nakayama, Nobukazu; Kawamata, Hiroshi; Nishimiya, Hiroshi; Ema, Akira; Narimatsu, Hisashi; Watanabe, Masahiko

2015-03-01

Glycoprotein expression profile is dramatically altered in human cancers; however, specific glycogenes have not been fully identified. A comprehensive real-time polymerase chain reaction (PCR) system for glycogenes (CRPS-G) identified several outstanding glycogenes. GCNT2 was of particular interest after GCNT2 expression and epigenetics were rigorously investigated in primary colorectal cancer (CRC). The highlights of this work can be summarized as follows: (i) Expression of GCNT2 was remarkably suppressed. (ii) Silenced expression of GCNT2 was reactivated by combined demethylating agents. (iii) Promoter DNA methylation of GCNT2 was silenced in CRC cell lines and tissues. Hypomethylation of GCNT2 variant 2 is tightly associated with lymph node metastasis in primary CRC. (iv) GCNT2 methylation level in the normal tissues also showed a close association with that in the tumor tissues and reflected lymph node metastasis. We identified aberrant expression of GCNT2, which can be explained by promoter DNA hypermethylation. Hypomethylation of the GCNT2 variant 2 reflected lymph node metastasis of CRC in the tumor and normal tissues. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

The Crc and Hfq proteins of Pseudomonas putida cooperate in catabolite repression and formation of ribonucleic acid complexes with specific target motifs.

Science.gov (United States)

Moreno, Renata; Hernández-Arranz, Sofía; La Rosa, Ruggero; Yuste, Luis; Madhushani, Anjana; Shingler, Victoria; Rojo, Fernando

2015-01-01

The Crc protein is a global regulator that has a key role in catabolite repression and optimization of metabolism in Pseudomonads. Crc inhibits gene expression post-transcriptionally, preventing translation of mRNAs bearing an AAnAAnAA motif [the catabolite activity (CA) motif] close to the translation start site. Although Crc was initially believed to bind RNA by itself, this idea was recently challenged by results suggesting that a protein co-purifying with Crc, presumably the Hfq protein, could account for the detected RNA-binding activity. Hfq is an abundant protein that has a central role in post-transcriptional gene regulation. Herein, we show that the Pseudomonas putida Hfq protein can recognize the CA motifs of RNAs through its distal face and that Crc facilitates formation of a more stable complex at these targets. Crc was unable to bind RNA in the absence of Hfq. However, pull-down assays showed that Crc and Hfq can form a co-complex with RNA containing a CA motif in vitro. Inactivation of the hfq or the crc gene impaired catabolite repression to a similar extent. We propose that Crc and Hfq cooperate in catabolite repression, probably through forming a stable co-complex with RNAs containing CA motifs to result in inhibition of translation initiation. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and colorectal cancer (CRC) risk.

Science.gov (United States)

Wang, Wei; Shao, Yan; Tang, Shenhua; Cheng, Xianyong; Lian, Haifeng; Qin, Chengyong

2015-01-01

The association between the peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and colorectal cancer (CRC) risk was inconclusive. We conducted a meta-analysis to evaluate the association between PPARγ Pro12Ala polymorphism and CRC risk. We searched Pubmed, EMBASE, and China National Knowledge Infrastructure databases. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. A total of 17 case-control studies with 12635 and 15803 controls were included in this meta-analysis. Overall, PPARγ Pro12Ala polymorphism was associated with CRC risk (OR = 0.84, 95% CI 0.75-0.94, P = 0.003, I(2) = 35%). In the subgroup analysis by ethnicity, a significant association was found among Caucasians (OR = 0.85, 95% CI 0.75-0.96, P = 0.007, I(2) = 38%) but not among Asians (OR = 0.76, 95% CI 0.51-1.12, P = 0.17, I(2) = 28%). In the subgroup analysis by CRC site, a significant association was found among colon cancer (OR = 0.81, 95% CI 0.66-0.98, P = 0.03, I(2) = 16%) but not among rectal cancer (OR = 0.83, 95% CI 0.57-1.21, P = 0.34, I(2) = 63%). The sensitivity analysis did not influence the result by omitting low-quality studies (OR = 0.76, 95% CI 0.63-0.93, P = 0.006, I(2) = 51%). In conclusion, this meta-analysis suggested that PPARγ Pro12Ala polymorphism was significant associated with CRC risk.

The Philosophical Genealogy of Taylor's Social Imaginaries: A Complex History of Ideas and Predecessors.

Science.gov (United States)

Vanheeswijck, Guido M

2017-01-01

The deepest sources of Charles Taylor's use of the concept "social imaginaries" are often related to political philosophy or social anthropology (Anderson, Castoriadis). The purpose of this article is to show that they also form part of Taylor's struggle to overcome the epistemological construal in modern philosophy and culture. Taylor locates the concept "social imaginaries" in the Kantian tradition, identifying their role to that of transcendental schemes. However, there remains a central difference between Kant's transcendental schemes and Taylor's social imaginaries. To elucidate that difference, this article will track the philosophical genealogy of Taylor's concept of "social imaginaries" in three steps.

Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.

Science.gov (United States)

Jansen, Anne M L; Geilenkirchen, Marije A; van Wezel, Tom; Jagmohan-Changur, Shantie C; Ruano, Dina; van der Klift, Heleen M; van den Akker, Brendy E W M; Laros, Jeroen F J; van Galen, Michiel; Wagner, Anja; Letteboer, Tom G W; Gómez-García, Encarna B; Tops, Carli M J; Vasen, Hans F; Devilee, Peter; Hes, Frederik J; Morreau, Hans; Wijnen, Juul T

2016-01-01

Lynch Syndrome (LS) is caused by pathogenic germline variants in one of the mismatch repair (MMR) genes. However, up to 60% of MMR-deficient colorectal cancer cases are categorized as suspected Lynch Syndrome (sLS) because no pathogenic MMR germline variant can be identified, which leads to difficulties in clinical management. We therefore analyzed the genomic regions of 15 CRC susceptibility genes in leukocyte DNA of 34 unrelated sLS patients and 11 patients with MLH1 hypermethylated tumors with a clear family history. Using targeted next-generation sequencing, we analyzed the entire non-repetitive genomic sequence, including intronic and regulatory sequences, of 15 CRC susceptibility genes. In addition, tumor DNA from 28 sLS patients was analyzed for somatic MMR variants. Of 1979 germline variants found in the leukocyte DNA of 34 sLS patients, one was a pathogenic variant (MLH1 c.1667+1delG). Leukocyte DNA of 11 patients with MLH1 hypermethylated tumors was negative for pathogenic germline variants in the tested CRC susceptibility genes and for germline MLH1 hypermethylation. Somatic DNA analysis of 28 sLS tumors identified eight (29%) cases with two pathogenic somatic variants, one with a VUS predicted to pathogenic and LOH, and nine cases (32%) with one pathogenic somatic variant (n = 8) or one VUS predicted to be pathogenic (n = 1). This is the first study in sLS patients to include the entire genomic sequence of CRC susceptibility genes. An underlying somatic or germline MMR gene defect was identified in ten of 34 sLS patients (29%). In the remaining sLS patients, the underlying genetic defect explaining the MMRdeficiency in their tumors might be found outside the genomic regions harboring the MMR and other known CRC susceptibility genes.

Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas aeruginosa.

Science.gov (United States)

Reales-Calderón, Jose Antonio; Corona, Fernando; Monteoliva, Lucía; Gil, Concha; Martínez, Jose Luis

2015-09-08

Recent research indicates that the post-transcriptional regulator Crc modulates susceptibility to antibiotics and virulence in Pseudomonas aeruginosa. Several P. aeruginosa virulence factors are secreted or engulfed in vesicles. To decipher the Crc modulation of P. aeruginosa virulence, we constructed a crc deficient mutant and measure the proteome associated extracellular vesicles and the vesicle-free secretome using iTRAQ. Fifty vesicle-associated proteins were more abundant and 14 less abundant in the crc-defective strain, whereas 37 were more abundant and 17 less abundant in the vesicle-free secretome. Among them, virulence determinants, such as ToxA, protease IV, azurin, chitin-binding protein, PlcB and Hcp1, were less abundant in the crc-defective mutant. Transcriptomic analysis revealed that some of the observed changes were post-transcriptional and, thus, could be attributed to a direct Crc regulatory role; whereas, for other differentially secreted proteins, the regulatory role was likely indirect. We also observed that the crc mutant presented an impaired vesicle-associated secretion of quorum sensing signal molecules and less cytotoxicity than its wild-type strain. Our results offer new insights into the mechanisms by which Crc regulates P. aeruginosa virulence, through the modulation of vesicle formation and secretion of both virulence determinants and quorum sensing signals. This article is part of a Special Issue entitled: HUPO 2014. Published by Elsevier B.V.

G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1.

Science.gov (United States)

Zhang, Jie; Wang, Yafang; Shen, Yanyan; He, Pengxing; Ding, Jian; Chen, Yi

2018-01-01

Rationale: G9a is genetically deregulated in various tumor types and is important for cell proliferation; however, the mechanism underlying G9a-induced carcinogenesis, especially in colorectal cancer (CRC), is unclear. Here, we investigated if G9a exerts oncogenic effects in CRC by increasing polo-like kinase 1 (Plk1) expression. Thus, we further characterized the detailed molecular mechanisms. Methods: The role of Plk1 in G9a aberrant CRC was determined by performing different in vitro and in vivo assays, including assessment of cell growth by performing cell viability assay and assessment of signaling transduction profiles by performing immunoblotting, in the cases of pharmacological inhibition or short RNA interference-mediated suppression of G9a. Detailed molecular mechanisms underlying the effect of G9a on Plk1 expression were determined by performing point mutation analysis, chromatin immunoprecipitation analysis, and luciferase reporter assay. Correlation between G9a and Plk1 expression was determined by analyzing clinical samples of patients with CRC by performing immunohistochemistry. Results: Our study is the first to report a significant positive correlation between G9a and Plk1 levels in 89 clinical samples of patients with CRC. Moreover, G9a depletion decreased Plk1 expression and suppressed CRC cell growth both in vitro and in vivo , thus confirming the significant correlation between G9a and Plk1 levels. Further, we observed that G9a-induced Plk1 regulation depended on p53 inhibition. G9a dimethylated p53 at lysine 373, which in turn increased Plk1 expression and promoted CRC cell growth. Conclusions: These results indicate that G9a-induced and p53-dependent epigenetic programing stimulates the growth of colon cancer, which also suggests that G9a inhibitors that restore p53 activity are promising therapeutic agents for treating colon cancer, especially for CRC expressing wild-type p53.

Neo-Taylorism in Educational Administration?

Science.gov (United States)

Gronn, Peter C.

1982-01-01

Reviews eight recent observational studies of school administrators and criticizes the studies' use of "time and motion" assumptions drawn from Frederick Winslow Taylor's ideas. Outlines an alternate approach based on "thick" description of administrators' work, including their talk, as exemplified in James Boswell's biography…

The Interpretation Of Metaphor Found In 20 Songs Of Taylor Swift

OpenAIRE

Desriani, Shella

2015-01-01

This paper entitled The interpretation of metaphor found in 20 of taylor swift. this paper discuss the types and meaning of metaphor in the lyrics of the song taylor swift. The purpose of this paper is to analyze types of metaphor in the form of simile, personification and hyperbole contained in the lyrics of the song taylor swift. In this paper the authors wrote the paper used the method of literature, collect some data from some books, and the internet. the lyric which contained metaphors i...

Rapid Calculation of Spacecraft Trajectories Using Efficient Taylor Series Integration

Science.gov (United States)

Scott, James R.; Martini, Michael C.

2011-01-01

A variable-order, variable-step Taylor series integration algorithm was implemented in NASA Glenn's SNAP (Spacecraft N-body Analysis Program) code. SNAP is a high-fidelity trajectory propagation program that can propagate the trajectory of a spacecraft about virtually any body in the solar system. The Taylor series algorithm's very high order accuracy and excellent stability properties lead to large reductions in computer time relative to the code's existing 8th order Runge-Kutta scheme. Head-to-head comparison on near-Earth, lunar, Mars, and Europa missions showed that Taylor series integration is 15.8 times faster than Runge- Kutta on average, and is more accurate. These speedups were obtained for calculations involving central body, other body, thrust, and drag forces. Similar speedups have been obtained for calculations that include J2 spherical harmonic for central body gravitation. The algorithm includes a step size selection method that directly calculates the step size and never requires a repeat step. High-order Taylor series integration algorithms have been shown to provide major reductions in computer time over conventional integration methods in numerous scientific applications. The objective here was to directly implement Taylor series integration in an existing trajectory analysis code and demonstrate that large reductions in computer time (order of magnitude) could be achieved while simultaneously maintaining high accuracy. This software greatly accelerates the calculation of spacecraft trajectories. At each time level, the spacecraft position, velocity, and mass are expanded in a high-order Taylor series whose coefficients are obtained through efficient differentiation arithmetic. This makes it possible to take very large time steps at minimal cost, resulting in large savings in computer time. The Taylor series algorithm is implemented primarily through three subroutines: (1) a driver routine that automatically introduces auxiliary variables and

Bubble behavior in a vertical Taylor-Couette flow

International Nuclear Information System (INIS)

Murai, Y; Oiwa, H; Takeda, Y

2005-01-01

Bubble distributions organized in a vertical Taylor-Couette flow are experimentally investigated. Modification of shear stress due to bubbles is measured with a torque sensor installed on the rotating inner cylinder. The wall shear stress decreases as bubbles are injected in all the tested range of Re from 600 to 4500. The drag reduction ratio per void fraction measured in the present experiment, which indicates net gain of the drag reduction, has been evaluated. The gain was more than unity for Re 4000. The maximum gain achieved was around 10 at Re = 600, at which point the bubbles dispersed widely on the inner cylinder surface and effectively restrict momentum exchange of fluid between the two walls. The expansion of Taylor vortices in the vertical direction by the presence of bubbles was confirmed by flow visualization including particle tracking velocimetry. Such bubble behaviours interacting with Taylor vortices are discussed in detail in this paper

Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC.

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Hu, Jianxia; Liu, Xiaoyi; Chi, Jingwei; Che, Kui; Feng, Yan; Zhao, Shihua; Wang, Zhongchao; Wang, Yangang

2018-01-01

Epidemiological data have revealed that colorectal cancer (CRC) risk is increased in patients with Metabolic syndrome. To explore the expressions of IGF-1, ERK, GLUT4, IRS-1 in MS patients with CRC and their associations with the clinical characteristics of CRC. We investigated the expressions of IGF-1, ERK, GLUT4 and IRS-1 in greater omental adipose tissues of 168 MS patients with/without CRC, 85 CRC patients without MS and 98 healthy controls by RT-PCR, and analyzed the relationships between their expressions and clinical characteristics of CRC. The expression levels of IGF-1 and ERK in MS patients with/without CRC were higher while the expression levels of GLUT4 were lower compared with CRC patients without MS and healthy controls (PCRC were higher while expression levels of GLUT4 were lower compared to MS patients without CRC (PCRC, including tumor size, distant metastasis and advanced stages (III/IV) (PCRC.

Photonic arbitrary waveform generator based on Taylor synthesis method

DEFF Research Database (Denmark)

Liao, Shasha; Ding, Yunhong; Dong, Jianji

2016-01-01

Arbitrary waveform generation has been widely used in optical communication, radar system and many other applications. We propose and experimentally demonstrate a silicon-on-insulator (SOI) on chip optical arbitrary waveform generator, which is based on Taylor synthesis method. In our scheme......, a Gaussian pulse is launched to some cascaded microrings to obtain first-, second- and third-order differentiations. By controlling amplitude and phase of the initial pulse and successive differentiations, we can realize an arbitrary waveform generator according to Taylor expansion. We obtain several typical...... waveforms such as square waveform, triangular waveform, flat-top waveform, sawtooth waveform, Gaussian waveform and so on. Unlike other schemes based on Fourier synthesis or frequency-to-time mapping, our scheme is based on Taylor synthesis method. Our scheme does not require any spectral disperser or large...

Taylor Hydro plant goes live

International Nuclear Information System (INIS)

Anon.

2000-01-01

The 12.75 MW Taylor Hydroelectric Plant in Magrath, Alberta, synchronized its generator with the Alberta Power Grid and began production in April 2000. The plant is located on Government of Alberta irrigation works and is owned by Canadian Hydro Developers. During the irrigation season the plant will generate approximately 40 million kilowatt hours of zero-emission 'green' power for consumption, enough to power 5,000 homes for a year. The Taylor plant is a joint venture with EPCOR Power Development Corporation, a wholly-owned subsidiary of EPCOR Inc., the City of Edmonton utility. Canadian Hydro Developers also owns a 19 MW wind plant and a 6 MW gas plant in Alberta and five other 'run of river' hydro plants in Ontario and British Columbia. The company is committed to the concept of low-impact power generation; its ownership of wind run-of-river hydro and gas-fired facilities is proof of that commitment

Micromixer based on Taylor dispersion

International Nuclear Information System (INIS)

Yang, H; Nguyen, N-T; Huang, X

2006-01-01

This paper reports an analytical model, the fabrication and the characterization of a polymeric micromixer based on Taylor dispersion. Due to the distributed velocity field over the channel cross section, the effective dispersion in axial direction in a microchannel is much stronger than the pure molecular diffusion. In our work, squential segmentation was used in the micromixer for improving mixing in a microchannel. The micromixer was designed and fabricated based on lamination of five 100-μm-thick polymer sheets. Rubber valve seats were embedded between the forth and the fifth layers. The polymer layers were machined using a CO 2 laser. The lamination of the five layers was carried out by a commercial hot laminator (Aurora LM-450HC). External solenoid actuators are used for closing the valves at the mixer inlets. The experimental results confirm the effect of Taylor dispersion. Mixing ratio can be adjusted by pulse width modulation of the control signal of the solenoids

Numerical simulation of Rayleigh-Taylor turbulent mixing layers

International Nuclear Information System (INIS)

Poujade, O.; Lardjane, N.; Peybernes, M.; Boulet, M.

2009-01-01

Accelerations in actual Rayleigh-Taylor instabilities are often variable. This article focuses on a particular class of variable accelerations where g(t) ∝ t n . A reference database is built from high resolution hydrodynamic numerical simulations. The successful comparison with a simple OD analytical model and the statistical 2SFK (2-Structure, 2-Fluid, 2-Turbulence) turbulence model is provided. Moreover, we show the difference between the mechanism at play in the Rayleigh-Taylor turbulent mixing zone and Kolmogorov's in the self similar developed turbulent regime. (authors)

Experience with S-1 in older Caucasian patients with metastatic colorectal cancer (mCRC)

DEFF Research Database (Denmark)

Winther, Stine Braendegaard; Zubcevic, Kanita; Qvortrup, Camilla

2016-01-01

BACKGROUND: An aging population will increase the number of older patients with metastatic colorectal cancer (mCRC). However, there is limited knowledge about treatment in older patients as they are under-represented in clinical trials. The oral fluoropyrimidine S-1 is associated with a lower rate...... of adverse events than capecitabine and may therefore be a suitable drug for elderly. However, data on the use of S-1 in Caucasian mCRC patients are lacking/scarce. MATERIAL AND METHODS: In the present study we evaluated safety and the efficacy of S-1 alone or in combination with oxaliplatin (SOx......) or irinotecan (IRIS) in older mCRC patients. Patients who received at least one cycle of S-1 (first-line therapy), SOx (mainly first-line therapy) or IRIS (second-line therapy) were included. RESULTS: From June 2012 to December 2014, 71 older patients received ≥1 cycle of either S-1 (n = 9), SOx (n = 44...

Towards finite density QCD with Taylor expansions

International Nuclear Information System (INIS)

Karsch, F.; Schaefer, B.-J.; Wagner, M.; Wambach, J.

2011-01-01

Convergence properties of Taylor expansions of observables, which are also used in lattice QCD calculations at non-zero chemical potential, are analyzed in an effective N f =2+1 flavor Polyakov quark-meson model. A recently developed algorithmic technique allows the calculation of higher-order Taylor expansion coefficients in functional approaches. This novel technique is for the first time applied to an effective N f =2+1 flavor Polyakov quark-meson model and the findings are compared with the full model solution at finite densities. The results are used to discuss prospects for locating the QCD phase boundary and a possible critical endpoint in the phase diagram.

The global regulator Crc plays a multifaceted role in modulation of type III secretion system in Pseudomonas aeruginosa.

Science.gov (United States)

Dong, Yi-Hu; Zhang, Xi-Fen; Zhang, Lian-Hui

2013-02-01

The opportunistic pathogen Pseudomonas aeruginosa utilizes type III secretion system (T3SS) to translocate effector proteins into eukaryotic host cells that subvert normal host cell functions to the benefit of the pathogen, and results in serious infections. T3SS in P. aeruginosa is controlled by a complex system of regulatory mechanisms and signaling pathways. In this study, we described that Crc, an RNA-binding protein, exerts a positive impact on T3SS in P. aeruginosa, as evidenced by promoter activity assays of several key T3SS genes, transcriptomics, RT-PCR, and immunoblotting in crc mutant. We further demonstrated that the regulatory function of Crc on the T3SS was mediated through the T3SS master regulator ExsA and linked to the Cbr/Crc signaling system. Expression profiling of the crc mutant revealed a downregulation of flagship T3SS genes as well as 16 other genes known to regulate T3SS gene expression in P. aeruginosa. On the basis of these data, we proposed that Crc may exert multifaceted control on the T3SS through various pathways, which may serve to fine-tune this virulence mechanism in response to environmental changes and nutrient sources. © 2012 The Authors. Published by Blackwell Publishing Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review).

Science.gov (United States)

Nikolouzakis, Taxiarchis Konstantinos; Vassilopoulou, Loukia; Fragkiadaki, Persefoni; Mariolis Sapsakos, Theodoros; Papadakis, Georgios Z; Spandidos, Demetrios A; Tsatsakis, Aristides M; Tsiaoussis, John

2018-06-01

Colorectal cancer (CRC) is among the most common cancers. In fact, it is placed in the third place among the most diagnosed cancer in men, after lung and prostate cancer, and in the second one for the most diagnosed cancer in women, following breast cancer. Moreover, its high mortality rates classifies it among the leading causes of cancer‑related death worldwide. Thus, in order to help clinicians to optimize their practice, it is crucial to introduce more effective tools that will improve not only early diagnosis, but also prediction of the most likely progression of the disease and response to chemotherapy. In that way, they will be able to decrease both morbidity and mortality of their patients. In accordance with that, colon cancer research has described numerous biomarkers for diagnostic, prognostic and predictive purposes that either alone or as part of a panel would help improve patient's clinical management. This review aims to describe the most accepted biomarkers among those proposed for use in CRC divided based on the clinical specimen that is examined (tissue, faeces or blood) along with their restrictions. Lastly, new insight in CRC monitoring will be discussed presenting promising emerging biomarkers (telomerase activity, telomere length and micronuclei frequency).

Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.

Science.gov (United States)

Gröschl, Benedikt; Bettstetter, Marcus; Giedl, Christian; Woenckhaus, Matthias; Edmonston, Tina; Hofstädter, Ferdinand; Dietmaier, Wolfgang

2013-04-01

DUSP4 (MKP-2), a member of the mitogen-activated protein kinase phosphatase (MKP) family and potential tumor suppressor, negatively regulates the MAPKs (mitogen-activated protein kinases) ERK, p38 and JNK. MAPKs play a crucial role in cancer development and progression. Previously, using microarray analyses we found a conspicuously frequent overexpression of DUSP4 in colorectal cancer (CRC) with high frequent microsatellite instability (MSI-H) compared to microsatellite stable (MSS) CRC. Here we studied DUSP4 expression on mRNA level in 38 CRC (19 MSI-H and 19 MSS) compared to matched normal tissue as well as in CRC cell lines by RT-qPCR. DUSP4 was overexpressed in all 19 MSI-H tumors and in 14 MSS tumors. Median expression levels in MSI-H tumors were significantly higher than in MSS-tumors (p CRC cell lines showed 6.8-fold higher DUSP4 mRNA levels than MSS cell lines. DUSP4 expression was not regulated by promoter methylation since no methylation was found by quantitative methylation analysis of DUSP4 promoter in CRC cell lines neither in tumor samples. Furthermore, no DUSP4 mutation was found on genomic DNA level in four CRC cell lines. DUSP4 overexpression in CRC cell lines through DUSP4 transfection caused upregulated expression of MAPK targets CDC25A, CCND1, EGR1, FOS, MYC and CDKN1A in HCT116 as well as downregulation of mismatch repair gene MSH2 in SW480. Furthermore, DUSP4 overexpression led to increased proliferation in CRC cell lines. Our findings suggest that DUSP4 acts as an important regulator of cell growth within the MAPK pathway and causes enhanced cell growth in MSI-H CRC. Copyright © 2012 UICC.

Stability of an expanding cylindrical plasma envelope: Rayleigh--Taylor instability

International Nuclear Information System (INIS)

Han, S.J.

1982-01-01

The stability of a cylindrically symmetric plasma envelope driven outward by blast waves is considered. The plasma fluid is assumed to be a compressible, isentropic gas describable as an ideal gas ( p = arho/sup γ/, γ>1). The stability problem of such an envelope undergoing self-similar motion is solved by considering the initial-value problem. It is shown that in the early phase of an expansion, the envelope is unstable to Rayleigh--Taylor modes which develop at the inner surface. In the later phase of the expansion, the Rayleigh--Taylor modes are weakened due to the geometrical divergence effect. The implications of the time-dependent behavior of the Rayleigh--Taylor instability for plasma switches are discussed

The Crc protein inhibits the production of polyhydroxyalkanoates in Pseudomonas putida under balanced carbon/nitrogen growth conditions.

Science.gov (United States)

La Rosa, Ruggero; de la Peña, Fernando; Prieto, María Axiliadora; Rojo, Fernando

2014-01-01

Pseudomonas putida synthesizes polyhydroxyalkanoates (PHAs) as storage compounds. PHA synthesis is more active when the carbon source is in excess and the nitrogen source is limiting, but can also occur at a lower rate under balanced carbon/nitrogen ratios. This work shows that PHA synthesis is controlled by the Crc global regulator, a protein that optimizes carbon metabolism by inhibiting the expression of genes involved in the use of non-preferred carbon sources. Crc acts post-transcriptionally. The mRNAs of target genes contain characteristic catabolite activity (CA) motifs near the ribosome binding site. Sequences resembling CA motifs can be predicted for the phaC1 gene, which codes for a PHA polymerase, and for phaI and phaF, which encode proteins associated to PHA granules. Our results show that Crc inhibits the translation of phaC1 mRNA, but not that of phaI or phaF, reducing the amount of PHA accumulated in the cell. Crc inhibited PHA synthesis during exponential growth in media containing a balanced carbon/nitrogen ratio. No inhibition was seen when the carbon/nitrogen ratio was imbalanced. This extends the role of Crc beyond that of controlling the hierarchical utilization of carbon sources and provides a link between PHA synthesis and the global regulatory networks controlling carbon flow. © 2013 Society for Applied Microbiology and John Wiley & Sons Ltd.

The translational repressor Crc controls the Pseudomonas putida benzoate and alkane catabolic pathways using a multi-tier regulation strategy.

Science.gov (United States)

Hernández-Arranz, Sofía; Moreno, Renata; Rojo, Fernando

2013-01-01

Metabolically versatile bacteria usually perceive aromatic compounds and hydrocarbons as non-preferred carbon sources, and their assimilation is inhibited if more preferable substrates are available. This is achieved via catabolite repression. In Pseudomonas putida, the expression of the genes allowing the assimilation of benzoate and n-alkanes is strongly inhibited by catabolite repression, a process controlled by the translational repressor Crc. Crc binds to and inhibits the translation of benR and alkS mRNAs, which encode the transcriptional activators that induce the expression of the benzoate and alkane degradation genes respectively. However, sequences similar to those recognized by Crc in benR and alkS mRNAs exist as well in the translation initiation regions of the mRNA of several structural genes of the benzoate and alkane pathways, which suggests that Crc may also regulate their translation. The present results show that some of these sites are functional, and that Crc inhibits the induction of both pathways by limiting not only the translation of their transcriptional activators, but also that of genes coding for the first enzyme in each pathway. Crc may also inhibit the translation of a gene involved in benzoate uptake. This multi-tier approach probably ensures the rapid regulation of pathway genes, minimizing the assimilation of non-preferred substrates when better options are available. A survey of possible Crc sites in the mRNAs of genes associated with other catabolic pathways suggested that targeting substrate uptake, pathway induction and/or pathway enzymes may be a common strategy to control the assimilation of non-preferred compounds. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial.

Science.gov (United States)

Banck-Petersen, Anna; Olsen, Cecilie K; Djurhuus, Sissal S; Herrstedt, Anita; Thorsen-Streit, Sarah; Ried-Larsen, Mathias; Østerlind, Kell; Osterkamp, Jens; Krarup, Peter-Martin; Vistisen, Kirsten; Mosgaard, Camilla S; Pedersen, Bente K; Højman, Pernille; Christensen, Jesper F

2018-03-01

Low physical activity level is associated with poor prognosis in patients with colorectal cancer (CRC). To increase physical activity, technology-based platforms are emerging and provide intriguing opportunities to prescribe and monitor active lifestyle interventions. The "Interval Walking in Colorectal Cancer"(I-WALK-CRC) study explores the feasibility and efficacy a home-based interval-walking intervention delivered by a smart-phone application in order to improve cardio-metabolic health profile among CRC survivors. The aim of the present report is to describe the design, methods and recruitment results of the I-WALK-CRC study.Methods/Results: The I-WALK-CRC study is a randomized controlled trial designed to evaluate the feasibility and efficacy of a home-based interval walking intervention compared to a waiting-list control group for physiological and patient-reported outcomes. Patients who had completed surgery for local stage disease and patients who had completed surgery and any adjuvant chemotherapy for locally advanced stage disease were eligible for inclusion. Between October 1st , 2015, and February 1st , 2017, 136 inquiries were recorded; 83 patients were eligible for enrollment, and 42 patients accepted participation. Age and employment status were associated with participation, as participants were significantly younger (60.5 vs 70.8 years, P CRC survivors was feasible but we aim to better the recruitment rate in future studies. Further, the study clearly favored younger participants. The I-WALK-CRC study will provide important information regarding feasibility and efficacy of a home-based walking exercise program in CRC survivors.

The β-catenin E3 ubiquitin ligase SIAH-1 is regulated by CSN5/JAB1 in CRC cells.

Science.gov (United States)

Jumpertz, Sandra; Hennes, Thomas; Asare, Yaw; Vervoorts, Jörg; Bernhagen, Jürgen; Schütz, Anke K

2014-09-01

COP9 signalosome subunit 5 (CSN5) plays a decisive role in cellular processes such as cell cycle regulation and apoptosis via promoting protein degradation, gene transcription, and nuclear export. CSN5 regulates cullin-RING-E3 ligase (CRL) activity through its deNEDDylase function. It is overexpressed in several tumor entities, but its role in colorectal cancer (CRC) is poorly understood. Wnt/β-catenin signaling is aberrant in most CRC cells, resulting in increased levels of oncogenic β-catenin and thus tumor progression. Under physiological conditions, β-catenin levels are tightly regulated by continuous proteasomal degradation. We recently showed that knockdown of CSN5 in model and CRC cells results in decreased (phospho)-β-catenin levels. Reduced β-catenin levels were associated with an attenuated proliferation rate of different CRC cell types after CSN5 knockdown. The canonical Wnt pathway involves degradation of β-catenin by a β-TrCP1-containing E3 ligase, but is mostly non-functional in CRC cells. We thus hypothesized that alternative β-catenin degradation mediated by SIAH-1 (seven in absentia homolog-1), is responsible for the effect of CSN5 on β-catenin signaling in CRC cells. We found that SIAH-1 plays an essential role in β-catenin degradation in HCT116 CRC cells and that CSN5 affects β-catenin target gene expression in these cells. Of note, CSN5 affected SIAH-1 mRNA and SIAH-1 protein levels. Moreover, β-catenin and SIAH-1 form protein complexes with CSN5 in HCT116 cells. Lastly, we demonstrate that CSN5 promotes SIAH-1 degradation in HCT116 and SW480 cells and that this is associated with its deNEDDylase activity. In conclusion, we have identified a CSN5/β-catenin/SIAH-1 interaction network that might control β-catenin degradation in CRC cells. Copyright © 2014 Elsevier Inc. All rights reserved.

Assessing Religious Orientations: Replication and Validation of the Commitment-Reflectivity Circumplex (CRC Model

Directory of Open Access Journals (Sweden)

Steven L. Isaak

2017-09-01

Full Text Available The Commitment-Reflectivity Circumplex (CRC model is a structural model of religious orientation that was designed to help organize and clarify measurement of foundational aspect of religiousness. The current study successfully replicated the CRC model using multidimensional scaling, and further evaluated the reliability, structure, and validity of their measures in both a university student sample (Study 1 and a nationally representative sample (Study 2. All 10 subscales of the Circumplex Religious Orientation Inventory (CROI demonstrated good reliability across both samples. A two-week test-retest of the CROI showed that the subscales are stable over time. A confirmatory factor analysis of the CROI in the representative adult sample demonstrated good model fit. Finally, the CROI’s validity was examined in relation to the Intrinsic, Extrinsic and Quest measures. Overall, the CROI appears to clarify much of the ambiguity inherent in the established scales by breaking down what were very broad orientations into very specific suborientations. The results suggest that the CRC model is applicable for diverse populations of adults. In addition, the CROI appears to be construct valid with good structural and psychometric properties across all 10 subscales.

Fluctuation scaling, Taylor's law, and crime.

Directory of Open Access Journals (Sweden)

Quentin S Hanley

Full Text Available Fluctuation scaling relationships have been observed in a wide range of processes ranging from internet router traffic to measles cases. Taylor's law is one such scaling relationship and has been widely applied in ecology to understand communities including trees, birds, human populations, and insects. We show that monthly crime reports in the UK show complex fluctuation scaling which can be approximated by Taylor's law relationships corresponding to local policing neighborhoods and larger regional and countrywide scales. Regression models applied to local scale data from Derbyshire and Nottinghamshire found that different categories of crime exhibited different scaling exponents with no significant difference between the two regions. On this scale, violence reports were close to a Poisson distribution (α = 1.057 ± 0.026 while burglary exhibited a greater exponent (α = 1.292 ± 0.029 indicative of temporal clustering. These two regions exhibited significantly different pre-exponential factors for the categories of anti-social behavior and burglary indicating that local variations in crime reports can be assessed using fluctuation scaling methods. At regional and countrywide scales, all categories exhibited scaling behavior indicative of temporal clustering evidenced by Taylor's law exponents from 1.43 ± 0.12 (Drugs to 2.094 ± 0081 (Other Crimes. Investigating crime behavior via fluctuation scaling gives insight beyond that of raw numbers and is unique in reporting on all processes contributing to the observed variance and is either robust to or exhibits signs of many types of data manipulation.

Fluctuation scaling, Taylor's law, and crime.

Science.gov (United States)

Hanley, Quentin S; Khatun, Suniya; Yosef, Amal; Dyer, Rachel-May

2014-01-01

Fluctuation scaling relationships have been observed in a wide range of processes ranging from internet router traffic to measles cases. Taylor's law is one such scaling relationship and has been widely applied in ecology to understand communities including trees, birds, human populations, and insects. We show that monthly crime reports in the UK show complex fluctuation scaling which can be approximated by Taylor's law relationships corresponding to local policing neighborhoods and larger regional and countrywide scales. Regression models applied to local scale data from Derbyshire and Nottinghamshire found that different categories of crime exhibited different scaling exponents with no significant difference between the two regions. On this scale, violence reports were close to a Poisson distribution (α = 1.057 ± 0.026) while burglary exhibited a greater exponent (α = 1.292 ± 0.029) indicative of temporal clustering. These two regions exhibited significantly different pre-exponential factors for the categories of anti-social behavior and burglary indicating that local variations in crime reports can be assessed using fluctuation scaling methods. At regional and countrywide scales, all categories exhibited scaling behavior indicative of temporal clustering evidenced by Taylor's law exponents from 1.43 ± 0.12 (Drugs) to 2.094 ± 0081 (Other Crimes). Investigating crime behavior via fluctuation scaling gives insight beyond that of raw numbers and is unique in reporting on all processes contributing to the observed variance and is either robust to or exhibits signs of many types of data manipulation.

Perioperative FOLFOX4 plus bevacizumab for initially unresectable advanced colorectal cancer (NAVIGATE-CRC-01).

Science.gov (United States)

Suenaga, Mitsukuni; Fujimoto, Yoshiya; Matsusaka, Satoshi; Shinozaki, Eiji; Akiyoshi, Takashi; Nagayama, Satoshi; Fukunaga, Yosuke; Oya, Masatoshi; Ueno, Masashi; Mizunuma, Nobuyuki; Yamaguchi, Toshiharu

2015-01-01

Perioperative chemotherapy combined with surgery for liver metastases is considered an active strategy in metastatic colorectal cancer (CRC). However, its impact on initially unresectable, previously untreated advanced CRC, regardless of concurrent metastases, remains to be clarified. A Phase II study was conducted to evaluate the safety and efficacy of perioperative FOLFOX4 plus bevacizumab for initially unresectable advanced CRC. Patients with previously untreated advanced colon or rectal cancer initially diagnosed as unresectable advanced CRC (TNM stage IIIb, IIIc, or IV) but potentially resectable after neoadjuvant chemotherapy (NAC) were studied. Preoperatively, patients received six cycles of NAC (five cycles of neoadjuvant FOLFOX4 plus bevacizumab followed by one cycle of FOLFOX4 alone). The interval between the last dose of bevacizumab and surgery was at least 5 weeks. Six cycles of adjuvant FOLFOX4 plus bevacizumab were given after surgery. The completion rate of NAC and feasibility of curative surgery were the primary endpoints. An interim analysis was performed at the end of NAC in the 12th patient to assess the completion rate of NAC. The median follow-up time was 56 months. The characteristics of the patients were as follows: sex, eight males and four females; tumor location, sigmoid colon in three, ascending colon in one, and rectum (above the peritoneal reflection) in eight; stage, III in eight and IV in four (liver or lymph nodes). All patients completed six cycles of NAC. There were no treatment-related severe adverse events or deaths. An objective response to NAC was achieved in nine patients (75%), and no disease progression was observed. Eleven patients underwent curative tumor resection, including metastatic lesions. In December 2012, this Phase II study was terminated because of slow registration. Perioperative FOLFOX4 plus bevacizumab is well tolerated and has a promising response rate leading to curative surgery, which offers a survival

Atomic Power | Taylor | Zede Journal

African Journals Online (AJOL)

Zede Journal. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 3 (1968) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Atomic Power. D Taylor. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT ...

The role of RCAS1 as a biomarker in diagnosing CRC and monitoring tumor recurrence and metastasis.

Science.gov (United States)

Han, Su-xia; Wang, Jing; Wang, Li-juan; Jin, Gui-hua; Ying, Xia; He, Chen-chen; Guo, Xi-jing; Zhang, Jian-ying; Zhang, Ying; Zhu, Qing

2014-06-01

Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) plays an important role in tumor progression by helping tumor cell to escape from host immunological surveillance or modifying the characteristics of connective tissue around. RCAS1 may appropriately reflect the development and prognosis of tumor. In the study, we sought to identify the clinical significance of RCAS1 in colorectal cancer (CRC) diagnosis and tumor recurrence monitoring. Immunohistochemistry (IHC) with tissue array slides was preformed to analyze RCAS1 protein expression in CRC, colorectal polyps, and normal colon tissues. RCAS1 levels in colorectal cancer were significantly higher than those in colorectal polyps and normal colon tissues (PCRC are significantly higher than in healthy controls and polyps (PCRC was 82.1 %, which was higher than carcinoembryonic antigen (CEA). Especially in CEA-negative cases, the sensitivity of RCAS1 was 88.2 %. Finally, CRC patients who were followed up showed a serum RCAS1 level which significantly decreased after surgery (PCRC diagnosis but also useful for monitoring tumor recurrence. RCAS1 might be a supplementary serological marker for CRC.

Rayleigh-Taylor instability of cylindrical jets with radial motion

Energy Technology Data Exchange (ETDEWEB)

Chen, Xiang M. [GE Nuclear, Wilmington, NC (United States); Schrock, V.E.; Peterson, P.F. [Univ. of California, Berkeley, CA (United States)

1995-09-01

Rayleigh-Taylor instability of an interface between fluids with different densities subjected to accelleration normal to itself has interested researchers for almost a century. The classic analyses of a flat interface by Rayleigh and Taylor have shown that this type of instability depends on the direction of acceleration and the density differences of the two fluids. Plesset later analyzed the stability of a spherically symmetric flows (and a spherical interface) and concluded that the instability also depends on the velocity of the interface as well as the direction and magnitude of radial acceleration. The instability induced by radial motion in cylindrical systems seems to have been neglected by previous researchers. This paper analyzes the Rayleigh-Taylor type of the spherical case, the radial velocity also plays an important role. As an application, the example of a liquid jet surface in an Inertial Confinement Fusion (ICF) reactor design is analyzed.

NR2F2 inhibits Smad7 expression and promotes TGF-β-dependent epithelial-mesenchymal transition of CRC via transactivation of miR-21.

Science.gov (United States)

Wang, Hao; Nie, Lei; Wu, Lei; Liu, Qiufang; Guo, Xueyan

2017-03-25

Metastasis is one of the most decisive factors influencing CRC patient prognosis and current studies suggest that a molecular mechanism known as EMT broadly regulates cancer metastasis. NR2F2 is a key molecule in the development of CRC, but the roles and underlying mechanisms of NR2F2 in TGF-β induced EMT in CRC remain largely unknown. In the current study, we were interested to examine the role of NR2F2 in the TGF-β-induced EMT in CRC. Here, we found NR2F2 was upregulated in CRC cells and promotes TGF-β-induced EMT in CRC. Using comparative miRNA profiling TGF-β pre-treated CRC cells in which NR2F2 had been knocked down with that of control cells, we identified miR-21 as a commonly downregulated miRNA in HT29 cells treated with TGF-β and NR2F2 siRNA, and its downregulation inhibiting migration and invasion of CRC cells. Moreover, we found NR2F2 could transcriptional activated miR-21 expression by binding to miR-21 promoter in HT29 by ChIP and luciferase assay. In the last, our data demonstrated that Smad7 was the direct target of miR-21 in CRC cells. Thus, NR2F2 could promote TGF-β-induced EMT and inhibit Smad7 expression via transactivation of miR-21, and NR2F2 may be a new common therapeutic target for CRC. Copyright © 2017 Elsevier Inc. All rights reserved.

The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa.

Science.gov (United States)

Yang, Nana; Ding, Shuting; Chen, Feifei; Zhang, Xue; Xia, Yongjie; Di, Hongxia; Cao, Qiao; Deng, Xin; Wu, Min; Wong, Catherine C L; Tian, Xiao-Xu; Yang, Cai-Guang; Zhao, Jing; Lan, Lefu

2015-05-01

Rhamnolipid acts as a virulence factor during Pseudomonas aeruginosa infection. Here, we show that deletion of the catabolite repression control (crc) gene in P. aeruginosa leads to a rhamnolipid-negative phenotype. This effect is mediated by the down-regulation of rhl quorum sensing (QS). We discover that a disruption of the gene encoding the Lon protease entirely offsets the effect of crc deletion on the production of both rhamnolipid and rhl QS signal C4-HSL. Crc is unable to bind lon mRNA in vitro in the absence of the RNA chaperon Hfq, while Crc contributes to Hfq-mediated repression of the lon gene expression at a posttranscriptional level. Deletion of crc, which results in up-regulation of lon, significantly reduces the in vivo stability and abundance of the RhlI protein that synthesizes C4-HSL, causing the attenuation of rhl QS. Lon is also capable of degrading the RhlI protein in vitro. In addition, constitutive expression of rhlI suppresses the defects of the crc deletion mutant in rhamnolipid, C4-HSL and virulence on lettuce leaves. This study therefore uncovers a novel posttranscriptional regulatory cascade, Crc-Hfq/Lon/RhlI, for the regulation of rhamnolipid production and rhl QS in P. aeruginosa. © 2015 John Wiley & Sons Ltd.

Repainting, modifying, smashing Taylorism

OpenAIRE

Pruijt, Hans

2000-01-01

textabstractAbstract Survey data show that post-Tayloristic production concepts are not developing to the extent that many researchers had originally expected. It also is inadequate to portray post-Taylorism as a development that is happening, but just slower than expected. This is inadequate because there are counter-tendencies: the resurgence of the assembly line in the highly paradigmatic automobile assembly; the rise of the McDonalds-type organization; and continuing skills-replacing auto...

High reflectance Cr/C multilayer at 250 eV for soft X-ray polarimetry

Energy Technology Data Exchange (ETDEWEB)

Wen, Mingwu; Jiang, Li; Zhang, Zhong; Huang, Qiushi [MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering (IPOE), School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); Wang, Zhanshan, E-mail: wangzs@tongji.edu.cn [MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering (IPOE), School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); She, Rui; Feng, Hua [Department of Engineering Physics, Tsinghua University, Beijing (China); Wang, Hongchang [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom)

2015-10-01

X-ray reflection near 45° via multilayer mirrors can be used for astronomical polarization measurements. A Cr/C multilayer mirror (designed for X-ray polarimetry at 250 eV), with a period thickness of 3.86 nm and a bi-layer number of 100, was fabricated using direct current magnetron sputtering. Grazing incidence X-ray reflectometry at 8 keV and transmission electron microscopy were used to investigate the multilayer structure. Different models were introduced to fit the hard X-ray reflectivity curve, which indicates that the layer thickness of two materials slightly drifts from the bottom to the top of the stack. Both the chromium and carbon layers are amorphous with asymmetric interfaces, while the Cr-on-C interface is slightly wider. Based on the good quality of the multilayer structure, a high reflectivity of 21.8% for the s-polarized light was obtained at 250 eV at a grazing incidence angle of 40.7°. The fabricated Cr/C multilayer mirror exhibits high reflectivity and polarization levels in the energy region of 240 eV–260 eV. - Highlights: • We fabricated Cr/C multilayer with 3.8 nm d-spacing. • X-ray reflectometry was used to determine the exact structure of Cr/C multilayer. • A high reflectivity of 21.8% for the s-polarized light was obtained at 250 eV. • Both Cr and C were found to be amorphous with slightly asymmetric interfaces. • A 4-layer model was used to fit and explain the results.

Quantitative proteomic analysis of paired colorectal cancer and non-tumorigenic tissues reveals signature proteins and perturbed pathways involved in CRC progression and metastasis.

Science.gov (United States)

Sethi, Manveen K; Thaysen-Andersen, Morten; Kim, Hoguen; Park, Cheol Keun; Baker, Mark S; Packer, Nicolle H; Paik, Young-Ki; Hancock, William S; Fanayan, Susan

2015-08-03

Modern proteomics has proven instrumental in our understanding of the molecular deregulations associated with the development and progression of cancer. Herein, we profile membrane-enriched proteome of tumor and adjacent normal tissues from eight CRC patients using label-free nanoLC-MS/MS-based quantitative proteomics and advanced pathway analysis. Of the 948 identified proteins, 184 proteins were differentially expressed (P1.5) between the tumor and non-tumor tissue (69 up-regulated and 115 down-regulated in tumor tissues). The CRC tumor and non-tumor tissues clustered tightly in separate groups using hierarchical cluster analysis of the differentially expressed proteins, indicating a strong CRC-association of this proteome subset. Specifically, cancer associated proteins such as FN1, TNC, DEFA1, ITGB2, MLEC, CDH17, EZR and pathways including actin cytoskeleton and RhoGDI signaling were deregulated. Stage-specific proteome signatures were identified including up-regulated ribosomal proteins and down-regulated annexin proteins in early stage CRC. Finally, EGFR(+) CRC tissues showed an EGFR-dependent down-regulation of cell adhesion molecules, relative to EGFR(-) tissues. Taken together, this study provides a detailed map of the altered proteome and associated protein pathways in CRC, which enhances our mechanistic understanding of CRC biology and opens avenues for a knowledge-driven search for candidate CRC protein markers. Copyright © 2015 Elsevier B.V. All rights reserved.

Rayleigh-Taylor instability of cylindrical jets with radial motion

International Nuclear Information System (INIS)

Chen, X.M.; Schrock, V.E.; Peterson, P.F.

1997-01-01

Rayleigh-Taylor instability of an interface between fluids with different densities subjected to acceleration normal to itself has interested researchers for almost a century. The classic analyses of a flat interface by Rayleigh and Taylor have shown that this type of instability depends on the direction of acceleration and the density differences of the two fluids. Plesset later analyzed the stability of a spherically symmetric flows (and a spherical interface) and concluded that the instability also depends on the velocity of the interface as well as the direction and magnitude of radial acceleration. The instability induced by radial motion in cylindrical systems seems to have been neglected by previous researchers. This paper analyzes the Rayleigh-Taylor type of instability for a cylindrical surface with radial motions. The results of the analysis show that, like the spherical case, the radial velocity also plays an important role. As an application, the example of a liquid jet surface in an Inertial Confinement Fusion (ICF) reactor design is analyzed. (orig.)

Dynamic stabilization of the imploding-shell Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Boris, J.P.

1977-01-01

A method for dynamic stabilization of the Rayleigh-Taylor (R-T) instability on the surface of an imploding fusion pellet is discussed. The driving laser beams are modulated in intensity so the ablation layer is subject to a rapidly and strongly oscillating acceleration. A substantial band of the Rayleigh-Taylor instability spectrum can be stabilized by this oscillation even though the time average acceleration vector lies in the destabilizing direction. By adjusting the frequency, structure, and amplitude of the modulation, the band of dynamically stabilized modes can be made to include the most unstable and dangerous modes. Thus considerably higher aspect ratio shells (i.e., thinner shells) could implode successfully than had been previously considered stable enough. Both theory and numerical simulations support this conclusion for the case of laser-driven pellet implosions. Similar modulation via transverse beam oscillations or parallel bunching should also work to stabilize the most dangerous surface Rayleigh-Taylor modes in relativistic electron-, ion- and heavy ion-pellet fusion schemes. (U.K.)

The right versus the good? On the right in the Philosophy of Charles Taylor

Directory of Open Access Journals (Sweden)

Javier García Caladín

2013-05-01

Full Text Available The aim of this article is to analyze the famous confrontation between the right and the good. We start with the analysis of Charles Taylor about the different significances of the good and his criticism to a procedural and restrictive approach of the moral (such as Habermas and Kymlicka. Secondly, we review in depth the ethics of Taylor and we stress the vague remark of «the just» in the use of Taylor. Finally, we evaluate the deontological deficiencies of the ethics of Taylor and try to find other ways to complement it.

An Application of Taylor Models to the Nakao Method on ODEs

OpenAIRE

Yamamoto, Nobito; Komori, Takashi

2009-01-01

The authors give short survey on validated computaion of initial value problems for ODEs especially Taylor model methods. Then they propose an application of Taylor models to the Nakao method which has been developed for numerical verification methods on PDEs and apply it to initial value problems for ODEs with some numerical experiments.

Evaluating the impact of an educational intervention to increase CRC screening rates in the African American community: a preliminary study.

Science.gov (United States)

Philip, Errol J; DuHamel, Katherine; Jandorf, Lina

2010-10-01

Despite the acknowledged importance of colorectal cancer (CRC) screening and its proven prognostic benefit, African American men and women simultaneously possess the highest rates of CRC-related incidence and mortality (Swan et al. in Cancer 97(6):1528-1540, 2003) and lowest screening rates in the United States (Polite et al. in Med Clin N Am 89(4):771-793, 2005). Effective, targeted interventions that promote CRC screening for this community are therefore critical. The current study evaluated the impact of a print-based educational intervention on screening behavior and associated patient-based factors, including cancer-related knowledge, fatalism, worry, and decisional balance (pros-cons). One hundred and eighteen individuals (mean age = 56.08, SD = 5.58) who had not undergone screening were recruited from two health clinics in New York City. Each participant received educational print materials regarding the need for screening, the process of undergoing screening, and the benefits of regular CRC screening. One in four individuals had undergone post-intervention screening at a three-month follow-up. Whereas all participants reported a decrease in cancer-related worry (p benefits and barriers of screening may be critical in the decision to undergo CRC screening. Future interventions to increase CRC-screening rates for this community may be improved by focusing on these patient-based factors.

Expressing the remainder of the Taylor polynomial when the function lacks smoothness

Czech Academy of Sciences Publication Activity Database

Hošek, Radim

2017-01-01

Roč. 72, č. 3 (2017), s. 126-130 ISSN 0013-6018 Institutional support: RVO:67985840 Keywords : Taylor polynomial * Taylor theorem Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics http://www.ems-ph.org/doi/10.4171/EM/335

Sarcocystis in Biology of Foodborne Parasites CRC Press

Science.gov (United States)

People can contract infections by consuming beef infected with Sarcocystis hominis or pork infected with Sarcocystis suihominis. Proper cooking can eliminate this foodborne risk of infection. Here, the biology of such parasites is thoroughly reviewed, focusing on the epidemiology, diagnosis, treat...

Direct numerical simulation of the Rayleigh-Taylor instability with the spectral element method

International Nuclear Information System (INIS)

Zhang Xu; Tan Duowang

2009-01-01

A novel method is proposed to simulate Rayleigh-Taylor instabilities using a specially-developed unsteady three-dimensional high-order spectral element method code. The numerical model used consists of Navier-Stokes equations and a transport-diffusive equation. The code is first validated with the results of linear stability perturbation theory. Then several characteristics of the Rayleigh-Taylor instabilities are studied using this three-dimensional unsteady code, including instantaneous turbulent structures and statistical turbulent mixing heights under different initial wave numbers. These results indicate that turbulent structures of Rayleigh-Taylor instabilities are strongly dependent on the initial conditions. The results also suggest that a high-order numerical method should provide the capability of simulating small scale fluctuations of Rayleigh-Taylor instabilities of turbulent flows. (authors)

Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC).

Science.gov (United States)

Zhang, Tiening; Cai, Xun; Li, Qi; Xue, Peng; Chen, Zhixiao; Dong, Xiao; Xue, Ying

2016-07-05

Hsa-miRNA-875-5p (miR-875-5p) has recently been discovered to have anticancer efficacy in different organs. However, the role of miR-875-5p on colorectal carcinoma (CRC) is still ambiguous. In this study, we investigated the role of miR-875-5p on the development of CRC. The results indicated that miR-875-5p was significantly down-regulated in primary tumor tissues and very low levels were found in CRC cell lines. Ectopic expression of miR-875-5p in CRC cell lines significantly suppressed cell growth as evidenced by cell viability assay, colony formation assay and BrdU staining, through inhibition of cyclin D1, cyclin D2, CDK4 and up-regulation of p57(Kip2) and p21(Waf1/Cip1). In addition, miR-875-5p induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein Bcl2. Moreover, miR-875-5p inhibited cellular migration and invasiveness through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. Further, oncogene EGFR was revealed to be a putative target of miR-875-5p, which was inversely correlated with miR-875-5p expression in CRC. Taken together, our results demonstrated that miR-875-5p played a pivotal role on CRC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic EGFR.

Rayleigh Taylor instability of two superposed compressible fluids in un-magnetized plasma

International Nuclear Information System (INIS)

Sharma, P K; Tiwari, A; Argal, S; Chhajlani, R K

2014-01-01

The linear Rayleigh Taylor instability of two superposed compressible Newtonian fluids is discussed with the effect of surface tension which can play important roles in space plasma. As in both the superposed Newtonian fluids, the system is stable for potentially stable case and unstable for potentially unstable case in the present problem also. The equations of the problem are solved by normal mode method and a dispersion relation is obtained for such a system. The behaviour of growth rate is examined in the presence of surface tension and it is found that the surface tension has stabilizing influence on the Rayleigh Taylor instability of two superposed compressible fluids. Numerical analysis is performed to show the effect of sound velocity and surface tension on the growth rate of Rayleigh Taylor instability. It is found that both parameters have stabilizing influence on the growth rate of Rayleigh Taylor instability.

Randomized controlled dissemination study of community-to-clinic navigation to promote CRC screening: Study design and implications.

Science.gov (United States)

Larkey, Linda; Szalacha, Laura; Herman, Patricia; Gonzalez, Julie; Menon, Usha

2017-02-01

Regular screening facilitates early diagnosis of colorectal cancer (CRC) and reduction of CRC morbidity and mortality. Screening rates for minorities and low-income populations remain suboptimal. Provider referral for CRC screening is one of the strongest predictors of adherence, but referrals are unlikely among those who have no clinic home (common among poor and minority populations). This group randomized controlled study will test the effectiveness of an evidence based tailored messaging intervention in a community-to-clinic navigation context compared to no navigation. Multicultural, underinsured individuals from community sites will be randomized (by site) to receive CRC screening education only, or education plus navigation. In Phase I, those randomized to education plus navigation will be guided to make a clinic appointment to receive a provider referral for CRC screening. Patients attending clinic appointments will continue to receive navigation until screened (Phase II) regardless of initial arm assignment. We hypothesize that those receiving education plus navigation will be more likely to attend clinic appointments (H1) and show higher rates of screening (H2) compared to those receiving education only. Phase I group assignment will be used as a control variable in analysis of screening follow-through in Phase II. Costs per screening achieved will be evaluated for each condition and the RE-AIM framework will be used to examine dissemination results. The novelty of our study design is the translational dissemination model that will allow us to assess the real-world application of an efficacious intervention previously tested in a randomized controlled trial. Copyright © 2016. Published by Elsevier Inc.

MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC).

Science.gov (United States)

Tong, Feng; Ying, Youhua; Pan, Haihua; Zhao, Wei; Li, Hongchen; Zhan, Xiaoli

2018-01-17

MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated the clinical and prognostic value as well as biological function of miR-466 in colorectal cancer (CRC). Tumor and adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. miR-466 expression was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR). mRNA and protein levels of cyclin D1, apoptosis regulator BAX (BAX), and matrix metalloproteinase-2 (MMP-2) were analyzed by qRT-PCR and Western blot, respectively, in SW-620 CRC cells transfected with miR-466 mimics or negative control miRNA. Effects of miR-466 on SW-620 cell proliferation, cell cycle and apoptosis, and invasion were investigated using CCK-8 assay, flow cytometry and Transwell assay, respectively. miR-466 expression was significantly downregulated in tumor tissues compared to matched adjacent non-tumor tissues. Low expression of miR-466 was significantly correlated with the tumor size, Tumor Node Metastasis stage, lymph node metastasis, and distant metastasis. The overall survival of CRC patients with low miR-466 expression was significantly shorter compared to high-miR-466 expression group (log-rank test: p = 0.0103). Multivariate analysis revealed that low miR-466 expression was associated with poor prognosis in CRC patients. The ectopic expression of miR-466 suppressed cell proliferation and migration/invasion, as well as induced G0/G1 arrest and apoptosis in SW-620 cells. Moreover, the ectopic expression of miR-466 decreased the expression of cyclin D1 and MMP-2, but increased BAX expression in SW-620 cells. In conclusion, our findings demonstrated that miR-466 functions as a suppressor miRNA in CRC and may be used as a prognostic factor in these patients.

Why Wait Until Our Community Gets Cancer?: Exploring CRC Screening Barriers and Facilitators in the Spanish-Speaking Community in North Carolina.

Science.gov (United States)

Martens, Christa E; Crutchfield, Trisha M; Laping, Jane L; Perreras, Lexie; Reuland, Daniel S; Cubillos, Laura; Pignone, Michael P; Wheeler, Stephanie B

2016-12-01

Colorectal cancer (CRC) is a leading cause of death among Hispanics in the United States. Despite the benefits of CRC screening, many Hispanics are not being screened. Using a combined methodology of focus groups and discrete choice experiment (DCE) surveys, the objectives for this research were as follows: (1) to improve understanding of preferences regarding potential CRC screening program characteristics, and (2) to improve understanding of the barriers and facilitators around CRC screening with the Hispanic, immigrant community in North Carolina. Four gender-stratified focus groups were conducted and DCE surveys were administered to 38 Spanish-speaking individuals across four counties in North Carolina. In-depth content analysis was used to examine the focus group data; descriptive analyses and mean attribute importance scores for cost of screening and follow-up care, travel time, and test options were calculated from DCE data. Data analyses showed that this population has a strong interest in CRC screening but experience barriers such as lack of access to resources, cost uncertainty, and stigma. Some of these barriers are unique to their cultural experiences in the United States, such as an expressed lack of tailored CRC information. Based on the DCE, cost variables were more important than testing options or travel time. This study suggests that Hispanics may have a general awareness of and interest in CRC screening, but multiple barriers prevent them from getting screened. Special attention should be given to designing culturally and linguistically appropriate programs to improve access to healthcare resources, insurance, and associated costs among Hispanics.

Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.

Science.gov (United States)

Deevi, Ravi Kiran; Javadi, Arman; McClements, Jane; Vohhodina, Jekaterina; Savage, Kienan; Loughrey, Maurice Bernard; Evergren, Emma; Campbell, Frederick Charles

2018-04-01

Histological grading provides prognostic stratification of colorectal cancer (CRC) by scoring heterogeneous phenotypes. Features of aggressiveness include aberrant mitotic spindle configurations, chromosomal breakage, and bizarre multicellular morphology, but pathobiology is poorly understood. Protein kinase C zeta (PKCz) controls mitotic spindle dynamics, chromosome segregation, and multicellular patterns, but its role in CRC phenotype evolution remains unclear. Here, we show that PKCz couples genome segregation to multicellular morphology through control of interphase centrosome anchoring. PKCz regulates interdependent processes that control centrosome positioning. Among these, interaction between the cytoskeletal linker protein ezrin and its binding partner NHERF1 promotes the formation of a localized cue for anchoring interphase centrosomes to the cell cortex. Perturbation of these phenomena induced different outcomes in cells with single or extra centrosomes. Defective anchoring of a single centrosome promoted bipolar spindle misorientation, multi-lumen formation, and aberrant epithelial stratification. Collectively, these disturbances induce cribriform multicellular morphology that is typical of some categories of low-grade CRC. By contrast, defective anchoring of extra centrosomes promoted multipolar spindle formation, chromosomal instability (CIN), disruption of glandular morphology, and cell outgrowth across the extracellular matrix interface characteristic of aggressive, high-grade CRC. Because PKCz enhances apical NHERF1 intensity in 3D epithelial cultures, we used an immunohistochemical (IHC) assay of apical NHERF1 intensity as an indirect readout of PKCz activity in translational studies. We show that apical NHERF1 IHC intensity is inversely associated with multipolar spindle frequency and high-grade morphology in formalin-fixed human CRC samples. To conclude, defective PKCz control of interphase centrosome anchoring may underlie distinct categories of

Family history assessment for colorectal cancer (CRC) risk analysis - comparison of diagram- and questionnaire-based web interfaces.

Science.gov (United States)

Schultz, Michael; Seo, Steven Bohwan; Holt, Alec; Regenbrecht, Holger

2015-11-18

Colorectal cancer (CRC) has a high incidence, especially in New Zealand. The reasons for this are unknown. While most cancers develop sporadically, a positive family history, determined by the number and age at diagnosis of affected first and second degree relatives with CRC is one of the major factors, which may increase an individual's lifetime risk. Before a patient can be enrolled in a surveillance program a detailed assessment and documentation of the family history is important but time consuming and often inaccurate. The documentation is usually paper-based. Our aim was therefore to develop and validate the usability and efficacy of a web-based family history assessment tool for CRC suitable for the general population. The tool was also to calculate the risk and make a recommendation for surveillance. Two versions of an electronic assessment tool, diagram-based and questionnaire-based, were developed with the risk analysis and recommendations for surveillance based on the New Zealand Guidelines Group recommendations. Accuracy of our tool was tested prior to the study by comparing risk calculations based on family history by experienced gastroenterologists with the electronic assessment. The general public, visiting a local science fair were asked to use and comment on the usability of the two interfaces. Ninety people assessed and commented on the two interfaces. Both interfaces were effective in assessing the risk to develop CRC through their familial history for CRC. However, the questionnaire-based interface performed with significantly better satisfaction (p = 0.001) than the diagram-based interface. There was no difference in efficacy though. We conclude that a web-based questionnaire tool can assist in the accurate documentation and analysis of the family history relevant to determine the individual risk of CRC based on local guidelines. The calculator is now implemented and assessable through the web-page of a local charity for colorectal cancer

Rayleigh-Taylor instability and mushroom-pattern formation in a two-component Bose-Einstein condensate

International Nuclear Information System (INIS)

Sasaki, Kazuki; Suzuki, Naoya; Saito, Hiroki; Akamatsu, Daisuke

2009-01-01

The Rayleigh-Taylor instability at the interface in an immiscible two-component Bose-Einstein condensate is investigated using the mean field and Bogoliubov theories. Rayleigh-Taylor fingers are found to grow from the interface and mushroom patterns are formed. Quantized vortex rings and vortex lines are then generated around the mushrooms. The Rayleigh-Taylor instability and mushroom-pattern formation can be observed in a trapped system.

Slavnov-Taylor constraints for nontrivial backgrounds

International Nuclear Information System (INIS)

Binosi, D.; Quadri, A.

2011-01-01

We devise an algebraic procedure for the evaluation of Green's functions in SU(N) Yang-Mills theory in the presence of a nontrivial background field. In the ghost-free sector the dependence of the vertex functional on the background is shown to be uniquely determined by the Slavnov-Taylor identities in terms of a certain 1-PI correlator of the covariant derivatives of the ghost and the antighost fields. At nonvanishing background this amplitude is shown to encode the quantum deformations to the tree-level background-quantum splitting. The approach only relies on the functional identities of the model (Slavnov-Taylor identities, b-equation, antighost equation) and thus it is valid beyond perturbation theory, and, in particular, in a lattice implementation of the background field method. As an example of the formalism we analyze the ghost two-point function and the Kugo-Ojima function in an instanton background in SU(2) Yang-Mills theory, quantized in the background Landau gauge.

Contexto y pensamiento de Charles Taylor sobre el consenso

Directory of Open Access Journals (Sweden)

Doris Elena Ospina Muñoz

2017-01-01

Full Text Available El artículo sostiene que el consenso no es un tema de primer orden en la filosofía política de Charles Taylor, pero una lectura orientada al problema puede ofrecer los elementos para establecer una teoría sobre dicha noción e identificar los argumentos para su justificación. Además, se enfatiza en el contexto de discusión que permite introducir la filosofía de Taylor como un modo de pensar sobre el consenso, alternativo al constructivismo.

Rayleigh-Taylor/gravitational instability in dense magnetoplasmas

Energy Technology Data Exchange (ETDEWEB)

Ali, S., E-mail: shahid.ali@ncp.edu.p [National Centre for Physics, Quaid-i-Azam University Campus, Islamabad (Pakistan); IPFN, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Ahmed, Z. [COMSATS Institute of Information Technology, Department of Physics, Wah Campus (Pakistan); Mirza, Arshad M. [Theoretical Plasma Physics Group, Physics Department, Quaid-i-Azam University, Islamabad 45320 (Pakistan); Ahmad, I. [COMSATS Institute of Information Technology, Department of Physics, Islamabad Campus (Pakistan)

2009-08-10

The Rayleigh-Taylor instability is investigated in a nonuniform dense quantum magnetoplasma. For this purpose, a quantum hydrodynamical model is used for the electrons whereas the ions are assumed to be cold and classical. The dispersion relation for the Rayleigh-Taylor instability becomes modified with the quantum corrections associated with the Fermi pressure law and the quantum Bohm potential force. Numerically, it is found that the quantum speed and density gradient significantly modify the growth rate of RT instability. In a dense quantum magnetoplasma case, the linear growth rate of RT instability becomes significantly higher than its classical value and the modes are found to be highly localized. The present investigation should be useful in the studies of dense astrophysical magnetoplasmas as well as in laser-produced plasmas.

Rayleigh-Taylor/gravitational instability in dense magnetoplasmas

International Nuclear Information System (INIS)

Ali, S.; Ahmed, Z.; Mirza, Arshad M.; Ahmad, I.

2009-01-01

The Rayleigh-Taylor instability is investigated in a nonuniform dense quantum magnetoplasma. For this purpose, a quantum hydrodynamical model is used for the electrons whereas the ions are assumed to be cold and classical. The dispersion relation for the Rayleigh-Taylor instability becomes modified with the quantum corrections associated with the Fermi pressure law and the quantum Bohm potential force. Numerically, it is found that the quantum speed and density gradient significantly modify the growth rate of RT instability. In a dense quantum magnetoplasma case, the linear growth rate of RT instability becomes significantly higher than its classical value and the modes are found to be highly localized. The present investigation should be useful in the studies of dense astrophysical magnetoplasmas as well as in laser-produced plasmas.

Direct Numerical Simulation of the Rayleigh−Taylor Instability with the Spectral Element Method

International Nuclear Information System (INIS)

Xu, Zhang; Duo-Wang, Tan

2009-01-01

A novel method is proposed to simulate Rayleigh−Taylor instabilities using a specially-developed unsteady three-dimensional high-order spectral element method code. The numerical model used consists of Navier–Stokes equations and a transport-diffusive equation. The code is first validated with the results of linear stability perturbation theory. Then several characteristics of the Rayleigh−Taylor instabilities are studied using this three-dimensional unsteady code, including instantaneous turbulent structures and statistical turbulent mixing heights under different initial wave numbers. These results indicate that turbulent structures of Rayleigh–Taylor instabilities are strongly dependent on the initial conditions. The results also suggest that a high-order numerical method should provide the capability of simulating small scale fluctuations of Rayleigh−Taylor instabilities of turbulent flows. (fundamental areas of phenomenology (including applications))

An Attempt to Extend Taylor-Spence Drive Theory to Vocational Choice Behavior

Science.gov (United States)

Sharf, Richard S.

1972-01-01

Predictions were made from Taylor-Spence drive theory about vocational choice behavior. Although the results did not specifically support the predictions made from Taylor-Spence theory, they indicated the potential usefulness of certain concepts in this theory and suggested several lines of inquiry for further research. (Author)

Reconnaissance study of the Taylor Mountains pluton, southwestern Alaska

Science.gov (United States)

Hudson, Travis L.; Miller, Marti L.; Klimasauskas, Edward P.; Layer, Paul W.

2010-01-01

The Taylor Mountains pluton is a Late Cretaceous to early Tertiary (median age 65 + or ? 2 Ma) epizonal, composite biotite granite stock located about 235 km (145 mi) northeast of Dillingham in southwestern Alaska. This 30 km2 (12 mi2) pluton has sharp and discordant contacts with hornfels that developed in Upper Cretaceous clastic sedimentary rocks of the Kuskokwim Group. The three intrusive phases in the Taylor Mountains pluton, in order of emplacement, are (1) porphyritic granite containing large K-feldspar phenocrysts in a coarse-grained groundmass, (2) porphyritic granite containing large K-feldspar and smaller, but still coarse, plagioclase, quartz, and biotite phenocrysts in a fine-grained groundmass, and (3) fine-grained, leucocratic, equigranular granite. The porphyritic granites have different emplacement histories, but similar compositions; averages are 69.43 percent SiO2, 1.62 percent CaO, 5.23 percent FeO+MgO, 3.11 percent Na2O, and 4.50 percent K2O. The fine-grained, equigranular granite is distinctly felsic compared to porphyritic granite; it averages 75.3 percent SiO2, 0.49 percent CaO, 1.52 percent FeO+MgO, 3.31 percent Na2O, and 4.87 percent K2O. Many trace elements including Ni, Cr, Sc, V, Ba, Sr, Zr, Y, Nb, La, Ce, Th, and Nd are strongly depleted in fine-grained equigranular granite. Trace elements are not highly enriched in any of the granites. Known hydrothermal alteration is limited to one tourmaline-quartz replacement zone in porphyritic granite. Mineral deposits in the Taylor Mountains area are primarily placer gold (plus wolframite, cassiterite, and cinnabar); sources for these likely include scattered veins in hornfels peripheral to the Taylor Mountain pluton. The granite magmas that formed the Taylor Mountains pluton are thought to represent melted continental crust that possibly formed in response to high heat flow in the waning stage of Late Cretaceous subduction beneath interior Alaska.

A cosmological Slavnov-Taylor identity

Science.gov (United States)

Collins, Hael; Holman, R.; Vardanyan, Tereza

2014-12-01

We develop a method for treating the consistency relations of inflation that includes the full time-evolution of the state. This approach relies only on the symmetries of the inflationary setting, in particular a residual conformal symmetry in the spatial part of the metric, along with general properties which hold for any quantum field theory. As a result, the consistency relations that emerge, which are essentially the Slavnov-Taylor identities associated with this residual conformal symmetry, apply very generally: they are true of the full Green's functions, hold largely independently of the particular inflationary model, and can be used for arbitrary states. We illustrate these techniques by showing the form assumed by the standard consistency relation between the two and three-point functions for the primordial scalar fluctuations when they are in a Bunch-Davies state. But because we have included the full evolution of the state, this approach works for a general initial state as well and does not need to have assumed that inflation began in the Bunch-Davies state. We explain how the Slavnov-Taylor identity is modified for these more general states.

Quantum effects on the Rayleigh-Taylor instability in a horizontal inhomogeneous rotating plasma

International Nuclear Information System (INIS)

Hoshoudy, G. A.

2009-01-01

The Rayleigh-Taylor instability is studied analytically in inhomogeneous plasma rotating uniformly in an external transverse magnetic field. The influence of the quantum mechanism is considered. For a stratified layer the linear growth rate is obtained. Some special cases that isolate the effect of various parameters on the growth rate of the Rayleigh-Taylor instability are discussed. It is shown that for some cases, the presence of the external transverse magnetic field beside the quantum effect will bring about more stability on the Rayleigh-Taylor instability.

Effects of thermal conduction and compressibility on Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Takabe, Hideaki; Mima, Kunioki.

1980-01-01

In order to study the stability of the ablation front in laser driven implosion, the thermal conduction and compressibility effects on the Rayleigh-Taylor instability are considered. It is found that the thermal conduction effect cannot stabilize the Rayleigh-Taylor mode, but reduce the growth rate in the short wavelength case. But, the growth rate is found not to differ from the classical value √gk in the long wavelength limit, where the compressibility is essential. (author)

Taylor Dispersion Analysis as a promising tool for assessment of peptide-peptide interactions.

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Høgstedt, Ulrich B; Schwach, Grégoire; van de Weert, Marco; Østergaard, Jesper

2016-10-10

Protein-protein and peptide-peptide (self-)interactions are of key importance in understanding the physiochemical behavior of proteins and peptides in solution. However, due to the small size of peptide molecules, characterization of these interactions is more challenging than for proteins. In this work, we show that protein-protein and peptide-peptide interactions can advantageously be investigated by measurement of the diffusion coefficient using Taylor Dispersion Analysis. Through comparison to Dynamic Light Scattering it was shown that Taylor Dispersion Analysis is well suited for the characterization of protein-protein interactions of solutions of α-lactalbumin and human serum albumin. The peptide-peptide interactions of three selected peptides were then investigated in a concentration range spanning from 0.5mg/ml up to 80mg/ml using Taylor Dispersion Analysis. The peptide-peptide interactions determination indicated that multibody interactions significantly affect the PPIs at concentration levels above 25mg/ml for the two charged peptides. Relative viscosity measurements, performed using the capillary based setup applied for Taylor Dispersion Analysis, showed that the viscosity of the peptide solutions increased with concentration. Our results indicate that a viscosity difference between run buffer and sample in Taylor Dispersion Analysis may result in overestimation of the measured diffusion coefficient. Thus, Taylor Dispersion Analysis provides a practical, but as yet primarily qualitative, approach to assessment of the colloidal stability of both peptide and protein formulations. Copyright © 2016 Elsevier B.V. All rights reserved.

On generalizations of the series of Taylor, Lagrange, Laurent and Teixeira

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L. M. B. C. Campos

1990-01-01

Full Text Available The classical theorems of Taylor, Lagrange, Laurent and Teixeira, are extended from the representation of a complex function F(z, to its derivative F(ν(z of complex order ν, understood as either a ‘Liouville’ (1832 or a ‘Rieman (1847’ differintegration (Campos 1984, 1985; these results are distinct from, and alternative to, other extensions of Taylor's series using differintegrations (Osler 1972, Lavoie & Osler & Tremblay 1976. We consider a complex function F(z, which is analytic (has an isolated singularity at ζ, and expand its derivative of complex order F(ν(z, in an ascending (ascending-descending series of powers of an auxiliary function f(z, yielding the generalized Teixeira (Lagrange series, which includes, for f(z=z−ζ, the generalized Taylor (Laurent series. The generalized series involve non-integral powers and/or coefficients evaluated by fractional derivatives or integrals, except in the case ν=0, when the classical theorems of Taylor (1715, Lagrange (1770, Laurent (1843 and Teixeira (1900 are regained. As an application, these generalized series can be used to generate special functions with complex parameters (Campos 1986, e.g., the Hermite and Bessel types.

Dominant Taylor Spectrum and Invariant Subspaces

Czech Academy of Sciences Publication Activity Database

Ambrozie, Calin-Grigore; Müller, Vladimír

2009-01-01

Roč. 61, č. 1 (2009), s. 101-111 ISSN 0379-4024 R&D Projects: GA ČR(CZ) GA201/06/0128 Institutional research plan: CEZ:AV0Z10190503 Keywords : Taylor spectrum * Scott-Brown technique * dominant spectrum Subject RIV: BA - General Mathematics Impact factor: 0.580, year: 2009

A Quality Improvement Initiative to Increase Colorectal Cancer (CRC) Screening: Collaboration between a Primary Care Clinic and Research Team.

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Green, Beverly B; Fuller, Sharon; Anderson, Melissa L; Mahoney, Christine; Mendy, Peter; Powell, Susan L

2017-01-01

Multiple randomized controlled trials have demonstrated that mailed fecal testing programs are effective in increasing colorectal cancer screening participation. However, few healthcare organization in the US have Implemented such programs. Stakeholders from one clinic in an integrated healthcare system in Washington State initiated collaboration with researchers with expertise in CRC screening, aiming to increase screening rates at their clinic. Age-eligible individuals who were overdue for CRC screening and had previously completed a fecal test were randomized to receive mailed fecal immunochemical test kits (FIT) at the start of the project (Early) or 6 months later (Late). Outcomes included comparing FIT completion at 6 months by randomization group, and overall CRC screening rates at 12 months. We also assessed implementation facilitators and challenges. Overall 2,421 FIT tests were mailed at a cost of $10,739. At 6 months, FIT completion was significantly higher among the Early compared to the Late group (62% vs.47%, p CRC screening rate was 75.1% at baseline and 78.0% 12 months later. Key constructs associated with successful program implementation included strong stakeholder involvement, use of evidence-based strategies, simplicity, and low cost. Challenges included lack of a plan for maintaining the program. Collaboration between clinic stakeholders and researchers led to a successful project that rapidly increased CRC screening rates. However, institutional normalization of the program would be required to maintain it.

Barriers to CRC Screening among Latino Adults in Pennsylvania: ACCN Results

Science.gov (United States)

Garcia-Dominic, Oralia; Lengerich, Eugene J.; Wray, Linda A.; Parrott, Roxanne; Aumiller, Betsy; Kluhsman, Brenda; Renderos, Carlos; Dignan, Mark

2012-01-01

Objectives: To describe knowledge of and barriers to colorectal cancer (CRC) screening by sex and geography among Latino adults in Pennsylvania. Methods: Eighty-two Latinos greater than 50 years old engaged in one of 8 focus groups. Focus groups consisted of 4 components. Focus group data were audiotaped, transcribed, and grouped into thematic…

Hereditary Colorectal Cancer (CRC Program in Latvia

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Irmejs Arvids

2003-12-01

Full Text Available Abstract Introduction The aim of the study is to evaluate the incidence and phenotype - genotype characteristics of hereditary colorectal cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives affected by these syndromes. Materials and methods From 02/1999-09/2002 in several hospitals in Latvia cancer family histories were collected from 865 patients with CRC. In families suspected of having a history consistent with a hereditary colorectal cancer syndrome, DNA testing for MLH1, MSH2 and MSH6 genes was performed. In addition immunohistochemical (IH examination of the normal and cancer tissue from large bowel tumors for MSH2 and MSH6 protein expression was performed prior to DNA analysis. Results From the 865 CRC cases only 3 (0.35% pedigrees fulfilled the Amsterdam II criteria of Hereditary Nonpolyposis Colorectal Cancer (HNPCC and 15 cases (1.73% were suspected of HNPCC. In 69 cases (8% with a cancer family aggregation (CFA were identified. Thus far 27 IH analyses have been performed and in 3 cancers homogenous lack of MSH2 or MSH6 protein expression was found. In one of these cases a mutation in MSH6 was identified. In 18 patients suspected of HNPCC or of matching the Amsterdam II criteria, denaturing high performance liquid chromatography (DHPLC followed by DNA sequencing of any heteroduplexes of the 35 exons comprising both MLH1 and MSH2 was performed revealing 3 mutations. For all of kindreds diagnosed definitively or with a high probability of being an HNPCC family appropriate recommendations concerning prophylactic measures, surveillance and treatment were provided in written form. Conclusions Existing pedigree/clinical data suggest that in Latvia the frequency of HNPCC is around 2% of consecutive colorectal cancer patients. It is crucial that genetic counseling is an integral part of cancer family syndrome management.

The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis.

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Song, Lele; Jia, Jia; Peng, Xiumei; Xiao, Wenhua; Li, Yuemin

2017-06-08

The SEPT9 gene methylation assay is the first FDA-approved blood assay for colorectal cancer (CRC) screening. Fecal immunochemical test (FIT), FIT-DNA test and CEA assay are also in vitro diagnostic (IVD) tests used in CRC screening. This meta-analysis aims to review the SEPT9 assay performance and compare it with other IVD CRC screening tests. By searching the Ovid MEDLINE, EMBASE, CBMdisc and CJFD database, 25 out of 180 studies were identified to report the SEPT9 assay performance. 2613 CRC cases and 6030 controls were included, and sensitivity and specificity were used to evaluate its performance at various algorithms. 1/3 algorithm exhibited the best sensitivity while 2/3 and 1/1 algorithm exhibited the best balance between sensitivity and specificity. The performance of the blood SEPT9 assay is superior to that of the serum protein markers and the FIT test in symptomatic population, while appeared to be less potent than FIT and FIT-DNA tests in asymptomatic population. In conclusion, 1/3 algorithm is recommended for CRC screening, and 2/3 or 1/1 algorithms are suitable for early detection for diagnostic purpose. The SEPT9 assay exhibited better performance in symptomatic population than in asymptomatic population.

29 CFR 37.64 - What procedures must the Director follow when CRC has completed a post-approval compliance review?

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true What procedures must the Director follow when CRC has completed a post-approval compliance review? 37.64 Section 37.64 Labor Office of the Secretary of Labor... (WIA) Compliance Procedures § 37.64 What procedures must the Director follow when CRC has completed a...

Analytical and numerical analysis of finite amplitude Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Meiron, D.I.; Saffman, P.G.

1987-01-01

We summarize the results obtained in the last year. These include a simple model of bubble competition in Rayleigh-Taylor unstable flows which gives results which are in good agreement with experiment. In addition the model has been compared with two dimensional numerical simulations of inviscid Rayleigh-Taylor instability using the cloud-in-cell method. These simulations can now be run into the late time regime and can track the competition of as many as ten bubbles. The improvement in performance over previous applications of the cloud-in-cell approach is due to the application of finite difference techniques designed to handle shock-like structures in the vorticity of the interface which occur at late times. We propose to extend the research carried thus far to Rayleigh-Taylor problems in three dimensional and convergent geometries as well as to two-fluid instabilities in which interface roll-up is observed. Finally we present a budget for the fiscal year 1987-1988. 6 refs

Millimeter-wave spectroscopy of CrC (X(3)Σ(-)) and CrCCH (X̃ (6)Σ(+)): Examining the chromium-carbon bond.

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Min, J; Ziurys, L M

2016-05-14

Pure rotational spectroscopy of the CrC (X(3)Σ(-)) and CrCCH (X̃ (6)Σ(+)) radicals has been conducted using millimeter/sub-millimeter direct absorption methods in the frequency range 225-585 GHz. These species were created in an AC discharge of Cr(CO)6 and either methane or acetylene, diluted in argon. Spectra of the CrCCD were also recorded for the first time using deuterated acetylene as the carbon precursor. Seven rotational transitions of CrC were measured, each consisting of three widely spaced, fine structure components, arising from spin-spin and spin-rotation interactions. Eleven rotational transitions were recorded for CrCCH and five for CrCCD; each transition in these cases was composed of a distinct fine structure sextet. These measurements confirm the respective (3)Σ(-) and (6)Σ(+) ground electronic states of these radicals, as indicated from optical studies. The data were analyzed using a Hund's case (b) Hamiltonian, and rotational, spin-spin, and spin-rotation constants have been accurately determined for all three species. The spectroscopic parameters for CrC were significantly revised from previous optical work, while those for CrCCH are in excellent agreement; completely new constants were established for CrCCD. The chromium-carbon bond length for CrC was calculated to be 1.631 Å, while that in CrCCH was found to be rCr-C = 1.993 Å - significantly longer. This result suggests that a single Cr-C bond is present in CrCCH, preserving the acetylenic structure of the ligand, while a triple bond exists in CrC. Analysis of the spin constants suggests that CrC has a nearby excited (1)Σ(+) state lying ∼16 900 cm(-1) higher in energy, and CrCCH has a (6)Π excited state with E ∼ 4800 cm(-1).

Backbone and stereospecific (13)C methyl Ile (δ1), Leu and Val side-chain chemical shift assignments of Crc.

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Sharma, Rakhi; Sahu, Bhubanananda; Ray, Malay K; Deshmukh, Mandar V

2015-04-01

Carbon catabolite repression (CCR) allows bacteria to selectively assimilate a preferred compound among a mixture of several potential carbon sources, thus boosting growth and economizing the cost of adaptability to variable nutrients in the environment. The RNA-binding catabolite repression control (Crc) protein acts as a global post-transcriptional regulator of CCR in Pseudomonas species. Crc triggers repression by inhibiting the expression of genes involved in transport and catabolism of non-preferred substrates, thus indirectly favoring assimilation of preferred one. We report here a nearly complete backbone and stereospecific (13)C methyl side-chain chemical shift assignments of Ile (δ1), Leu and Val of Crc (~ 31 kDa) from Pseudomonas syringae Lz4W.

Taylor O(h³) Discretization of ZNN Models for Dynamic Equality-Constrained Quadratic Programming With Application to Manipulators.

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Liao, Bolin; Zhang, Yunong; Jin, Long

2016-02-01

In this paper, a new Taylor-type numerical differentiation formula is first presented to discretize the continuous-time Zhang neural network (ZNN), and obtain higher computational accuracy. Based on the Taylor-type formula, two Taylor-type discrete-time ZNN models (termed Taylor-type discrete-time ZNNK and Taylor-type discrete-time ZNNU models) are then proposed and discussed to perform online dynamic equality-constrained quadratic programming. For comparison, Euler-type discrete-time ZNN models (called Euler-type discrete-time ZNNK and Euler-type discrete-time ZNNU models) and Newton iteration, with interesting links being found, are also presented. It is proved herein that the steady-state residual errors of the proposed Taylor-type discrete-time ZNN models, Euler-type discrete-time ZNN models, and Newton iteration have the patterns of O(h(3)), O(h(2)), and O(h), respectively, with h denoting the sampling gap. Numerical experiments, including the application examples, are carried out, of which the results further substantiate the theoretical findings and the efficacy of Taylor-type discrete-time ZNN models. Finally, the comparisons with Taylor-type discrete-time derivative model and other Lagrange-type discrete-time ZNN models for dynamic equality-constrained quadratic programming substantiate the superiority of the proposed Taylor-type discrete-time ZNN models once again.

The Crc global regulator inhibits the Pseudomonas putida pWW0 toluene/xylene assimilation pathway by repressing the translation of regulatory and structural genes.

Science.gov (United States)

Moreno, Renata; Fonseca, Pilar; Rojo, Fernando

2010-08-06

In Pseudomonas putida, the expression of the pWW0 plasmid genes for the toluene/xylene assimilation pathway (the TOL pathway) is subject to complex regulation in response to environmental and physiological signals. This includes strong inhibition via catabolite repression, elicited by the carbon sources that the cells prefer to hydrocarbons. The Crc protein, a global regulator that controls carbon flow in pseudomonads, has an important role in this inhibition. Crc is a translational repressor that regulates the TOL genes, but how it does this has remained unknown. This study reports that Crc binds to sites located at the translation initiation regions of the mRNAs coding for XylR and XylS, two specific transcription activators of the TOL genes. Unexpectedly, eight additional Crc binding sites were found overlapping the translation initiation sites of genes coding for several enzymes of the pathway, all encoded within two polycistronic mRNAs. Evidence is provided supporting the idea that these sites are functional. This implies that Crc can differentially modulate the expression of particular genes within polycistronic mRNAs. It is proposed that Crc controls TOL genes in two ways. First, Crc inhibits the translation of the XylR and XylS regulators, thereby reducing the transcription of all TOL pathway genes. Second, Crc inhibits the translation of specific structural genes of the pathway, acting mainly on proteins involved in the first steps of toluene assimilation. This ensures a rapid inhibitory response that reduces the expression of the toluene/xylene degradation proteins when preferred carbon sources become available.

Samuel Taylor Coleridge’s

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Aslı TEKİNAY

2000-01-01

Full Text Available There is a dark strain which can be traced in the poetry of all the major nineteenth century English romantic poets: a scepticism about the ultimate purpose of man's life, a sense of having lost a metaphysical certainty and faith in the presence of a benevolent power who maintains harmony and order in the universe. Samuel Taylor Coleridge is one of them. In "The Rime of the Ancient Mariner" and "Christabel", he reveals a nightmarish vision of the universe where moral order seems to be replaced by a cosmic "hap".

Characterization of the two-phase Taylor Couette flow

International Nuclear Information System (INIS)

Mehel A; Gabillet B; Djeridi H

2005-01-01

The focus of the present study concerns the effects of a dispersed phase on the structure of a quasi periodic Couette Taylor flow. The two phase flow patterns are investigated experimentally for the Taylor number Ta=780. Small bubbles (0.035 times as small as the gap) are generated by agitation of the upper free surface. Larger bubbles (0.15 times as small as the gap) are produced by injection at the bottom of the apparatus associated with a pressure drop. Void fraction, bubble size and velocity are measured, as well as the azimuthal and axial velocity components of the liquid. A premature transition to turbulence is pointed out and discussed according to the bubble size and their localization in the gap. (authors)

Applicability of Taylor's hypothesis in thermally driven turbulence

Science.gov (United States)

Kumar, Abhishek; Verma, Mahendra K.

2018-04-01

In this paper, we show that, in the presence of large-scale circulation (LSC), Taylor's hypothesis can be invoked to deduce the energy spectrum in thermal convection using real-space probes, a popular experimental tool. We perform numerical simulation of turbulent convection in a cube and observe that the velocity field follows Kolmogorov's spectrum (k-5/3). We also record the velocity time series using real-space probes near the lateral walls. The corresponding frequency spectrum exhibits Kolmogorov's spectrum (f-5/3), thus validating Taylor's hypothesis with the steady LSC playing the role of a mean velocity field. The aforementioned findings based on real-space probes provide valuable inputs for experimental measurements used for studying the spectrum of convective turbulence.

Effect of FLR correction on Rayleigh -Taylor instability of quantum and stratified plasma

International Nuclear Information System (INIS)

Sharma, P.K.; Tiwari, Anita; Argal, Shraddha; Chhajlani, R.K.

2013-01-01

The Rayleigh Taylor instability of stratified incompressible fluids is studied in presence of FLR Correction and quantum effects in bounded medium. The Quantum magneto hydrodynamic equations of the problem are solved by using normal mode analysis method. A dispersion relation is carried out for the case where plasma is bounded by two rigid planes z = 0 and z = h. The dispersion relation is obtained in dimensionless form to discuss the growth rate of Rayleigh Taylor instability in presence of FLR Correction and quantum effects. The stabilizing or destabilizing behavior of quantum effect and FLR correction on the Rayleigh Taylor instability is analyzed. (author)

Rayleigh-Taylor convective overturn in stellar collapse

International Nuclear Information System (INIS)

Bruenn, S.W.; Buchler, J.R.; Livio, M.

1979-01-01

Rayleigh--Taylor convective overturn in collapsing stellar cores is modeled with a one-dimensional parametrization. The results of a numerical hydrodynamic study are very encouraging and indicate that such an overturn could well be a dominant feature in the supernova explosion mechanism

Frictional Torque Reduction in Taylor-Couette Flows with Riblet-Textured Rotors

Science.gov (United States)

Raayai, Shabnam; McKinley, Gareth

2017-11-01

Inspired by the riblets on the denticles of fast swimming shark species, periodic surface microtextures of different shapes have been studied under laminar and turbulent flow conditions to understand their drag reduction mechanism and to offer guides for designing optimized low-friction bio-inspired surfaces. Various reports over the past four decades have suggested that riblet surfaces can reduce the frictional drag force in high Reynolds number laminar and turbulent flow regimes. Here, we investigate the effect of streamwise riblets on torque reduction in steady flow between concentric cylinders, known as Taylor-Couette Flow. Using 3D printed riblet-textured rotors and a custom-built Taylor-Couette cell which can be mounted on a rheometer we measure the torque on the inner rotor as a function of three different dimensionless parameters; the Reynolds number of the flow, the sharpness of the riblets, and the size of the riblets with respect to the scale of the Taylor-Couette cell. Our experimental results in the laminar viscous flow regime show a reduction in torque up to 10% over a wide range of Reynolds numbers, that is a non-monotonic function of the aspect ratio and independent of Re. However, after transition to the Taylor vortex regime, the modification in torque becomes a function of the Reynolds number, while remaining a non-monotonic function of the aspect ratio. Using finite volume modelling of the geometry we discuss the changes in the Taylor-Couette flow in presence of the riblets compared to the case of smooth rotors and the resulting torque reduction as a function of the parameter space defined above.

Fluid Dynamics And Mass Transfer In Two-Fluid Taylor-Couette Flow

International Nuclear Information System (INIS)

Baier, G.; Graham, M.D.

1998-01-01

The Taylor-Couette instability of a single liquid phase can be used to enhance mass transfer processes such as filtration and membrane separations. We consider here the possibility of using this instability to enhance interphase transport in a two-fluid systems, with a view toward improved liquid-liquid extractions for biotechnology applications. We investigate the centrifugal instability of a pair of radially stratified immiscible liquids in the annular gap between concentric, corotating cylinders: two-fluid Taylor-Couette flow. Experiments show that a two-layer flow with a well-defined interface and Taylor vortices in each phase can be obtained. The experimental results are in good agreement with predictions of inviscid arguments based on a two-phase extension of Rayleigh's criterion, as well as with detailed linear stability calculations. For a given geometry, the most stable configuration occurs for fluids of roughly (exactly in the inviscid limit) equal dynamic viscosities. A number of preliminary mass transfer experiments have also been performed, in the presence of axial counterflow. The onset of Taylor vortices coincides with a clear decrease in the extent of axial dispersion and an increase in the rate of interphase transport, thus suggesting that this flow geometry may provide an effective means for countercurrent chromatographic separations

Ethics, organ donation and tax: a reply to Quigley and Taylor.

Science.gov (United States)

Lippert-Rasmussen, Kasper; Petersen, Thomas Søbirk

2012-08-01

A national opt-out system of post-mortem donation of scarce organs is preferable to an opt-in system. Unfortunately, the former system is not always feasible, and so in a recent JME article we canvassed the possibility of offering people a tax break for opting-in as a way of increasing the number of organs available for donation under an opt-in regime. Muireann Quigley and James Stacey Taylor criticize our proposal. Roughly, Quigley argues that our proposal is costly and, hence, is unlikely to be implemented, while Taylor contests our response to a Titmuss-style objection to our scheme. In response to Quigley, we note that our proposal's main attraction lies in gains not reflected in the figures presented by Quigley and that the mere fact that it is costly does not imply that it is unfeasible. In response to Taylor, we offer some textual evidence in support of our interpretation of Taylor and responds to his favoured interpretation of the Titmuss-style objection that many people seem to want to donate to charities even if they can deduct their donations from their income tax. Finally, we show why our views do not commit us to endorsing a free organ-market.

Ekman-Hartmann layer in a magnetohydrodynamic Taylor-Couette flow.

Science.gov (United States)

Szklarski, Jacek; Rüdiger, Günther

2007-12-01

We study magnetic effects induced by rigidly rotating plates enclosing a cylindrical magnetohydrodynamic (MHD) Taylor-Couette flow at the finite aspect ratio HD=10 . The fluid confined between the cylinders is assumed to be liquid metal characterized by small magnetic Prandtl number, the cylinders are perfectly conducting, an axial magnetic field is imposed with Hartmann number Ha approximately 10 , and the rotation rates correspond to Reynolds numbers of order 10(2)-10(3). We show that the end plates introduce, besides the well-known Ekman circulation, similar magnetic effects which arise for infinite, rotating plates, horizontally unbounded by any walls. In particular, there exists the Hartmann current, which penetrates the fluid, turns in the radial direction, and together with the applied magnetic field gives rise to a force. Consequently, the flow can be compared with a Taylor-Dean flow driven by an azimuthal pressure gradient. We analyze the stability of such flows and show that the currents induced by the plates can give rise to instability for the considered parameters. When designing a MHD Taylor-Couette experiment, special care must be taken concerning the vertical magnetic boundaries so that they do not significantly alter the rotational profile.

Numerical study of Taylor bubbles with adaptive unstructured meshes

Science.gov (United States)

Xie, Zhihua; Pavlidis, Dimitrios; Percival, James; Pain, Chris; Matar, Omar; Hasan, Abbas; Azzopardi, Barry

2014-11-01

The Taylor bubble is a single long bubble which nearly fills the entire cross section of a liquid-filled circular tube. This type of bubble flow regime often occurs in gas-liquid slug flows in many industrial applications, including oil-and-gas production, chemical and nuclear reactors, and heat exchangers. The objective of this study is to investigate the fluid dynamics of Taylor bubbles rising in a vertical pipe filled with oils of extremely high viscosity (mimicking the ``heavy oils'' found in the oil-and-gas industry). A modelling and simulation framework is presented here which can modify and adapt anisotropic unstructured meshes to better represent the underlying physics of bubble rise and reduce the computational effort without sacrificing accuracy. The numerical framework consists of a mixed control-volume and finite-element formulation, a ``volume of fluid''-type method for the interface capturing based on a compressive control volume advection method, and a force-balanced algorithm for the surface tension implementation. Numerical examples of some benchmark tests and the dynamics of Taylor bubbles are presented to show the capability of this method. EPSRC Programme Grant, MEMPHIS, EP/K0039761/1.

Process development of starch hydrolysis using mixing characteristics of Taylor vortices.

Science.gov (United States)

Masuda, Hayato; Horie, Takafumi; Hubacz, Robert; Ohmura, Naoto; Shimoyamada, Makoto

2017-04-01

In food industries, enzymatic starch hydrolysis is an important process that consists of two steps: gelatinization and saccharification. One of the major difficulties in designing the starch hydrolysis process is the sharp change in its rheological properties. In this study, Taylor-Couette flow reactor was applied to continuous starch hydrolysis process. The concentration of reducing sugar produced via enzymatic hydrolysis was evaluated by varying operational variables: rotational speed of the inner cylinder, axial velocity (reaction time), amount of enzyme, and initial starch content in the slurry. When Taylor vortices were formed in the annular space, efficient hydrolysis occurred because Taylor vortices improved the mixing of gelatinized starch with enzyme. Furthermore, a modified inner cylinder was proposed, and its mixing performance was numerically investigated. The modified inner cylinder showed higher potential for enhanced mixing of gelatinized starch and the enzyme than the conventional cylinder.

3 CFR - Continuation of the National Emergency With Respect to the Former Liberian Regime of Charles Taylor

Science.gov (United States)

2010-01-01

... to the Former Liberian Regime of Charles Taylor Presidential Documents Other Presidential Documents... of Charles Taylor On July 22, 2004, by Executive Order 13348, the President declared a national... to the former Liberian regime of Charles Taylor, pursuant to the International Emergency Economic...

Student understanding of Taylor series expansions in statistical mechanics

Directory of Open Access Journals (Sweden)

Trevor I. Smith

2013-08-01

Full Text Available One goal of physics instruction is to have students learn to make physical meaning of specific mathematical expressions, concepts, and procedures in different physical settings. As part of research investigating student learning in statistical physics, we are developing curriculum materials that guide students through a derivation of the Boltzmann factor using a Taylor series expansion of entropy. Using results from written surveys, classroom observations, and both individual think-aloud and teaching interviews, we present evidence that many students can recognize and interpret series expansions, but they often lack fluency in creating and using a Taylor series appropriately, despite previous exposures in both calculus and physics courses.

Student understanding of Taylor series expansions in statistical mechanics

Science.gov (United States)

Smith, Trevor I.; Thompson, John R.; Mountcastle, Donald B.

2013-12-01

One goal of physics instruction is to have students learn to make physical meaning of specific mathematical expressions, concepts, and procedures in different physical settings. As part of research investigating student learning in statistical physics, we are developing curriculum materials that guide students through a derivation of the Boltzmann factor using a Taylor series expansion of entropy. Using results from written surveys, classroom observations, and both individual think-aloud and teaching interviews, we present evidence that many students can recognize and interpret series expansions, but they often lack fluency in creating and using a Taylor series appropriately, despite previous exposures in both calculus and physics courses.

Three-dimensional single-mode nonlinear ablative Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Yan, R.; Aluie, H.; Betti, R.; Sanz, J.; Liu, B.; Frank, A.

2016-01-01

The nonlinear evolution of the single-mode ablative Rayleigh-Taylor instability is studied in three dimensions. As the mode wavelength approaches the cutoff of the linear spectrum (short-wavelength modes), it is found that the three-dimensional (3D) terminal bubble velocity greatly exceeds both the two-dimensional (2D) value and the classical 3D bubble velocity. Unlike in 2D, the 3D short-wavelength bubble velocity does not saturate. The growing 3D bubble acceleration is driven by the unbounded accumulation of vorticity inside the bubble. The vorticity is transferred by mass ablation from the Rayleigh-Taylor spikes to the ablated plasma filling the bubble volume

Application of the Asymptotic Taylor Expansion Method to Bistable Potentials

Directory of Open Access Journals (Sweden)

Okan Ozer

2013-01-01

Full Text Available A recent method called asymptotic Taylor expansion (ATEM is applied to determine the analytical expression for eigenfunctions and numerical results for eigenvalues of the Schrödinger equation for the bistable potentials. Optimal truncation of the Taylor series gives a best possible analytical expression for eigenfunctions and numerical results for eigenvalues. It is shown that the results are obtained by a simple algorithm constructed for a computer system using symbolic or numerical calculation. It is observed that ATEM produces excellent results consistent with the existing literature.

Approximate expressions for the period of a simple pendulum using a Taylor series expansion

International Nuclear Information System (INIS)

Belendez, Augusto; Marquez, Andres; Ortuno, Manuel; Gallego, Sergi; Arribas, Enrique

2011-01-01

An approximate scheme for obtaining the period of a simple pendulum for large-amplitude oscillations is analysed and discussed. When students express the exact frequency or the period of a simple pendulum as a function of the oscillation amplitude, and they are told to expand this function in a Taylor series, they always do so using the oscillation amplitude as the variable, without considering that if they change the variable (in this paper to the new variable m), a different Taylor series expansion may be performed which is in addition more accurate than previously published ones. Students tend to believe that there is one and only one way of performing a Taylor series expansion of a specific function. The approximate analytical formula for the period is obtained by means of a Taylor expansion of the exact frequency taking into account the Kidd-Fogg formula for the period. This approach based on the Taylor expansion of the frequency about a suitable value converges quickly even for large amplitudes. We believe that this method may be very useful for teaching undergraduate courses on classical mechanics and helping students understand nonlinear oscillations of a simple pendulum.

Approximate expressions for the period of a simple pendulum using a Taylor series expansion

Energy Technology Data Exchange (ETDEWEB)

Belendez, Augusto; Marquez, Andres; Ortuno, Manuel; Gallego, Sergi [Departamento de Fisica, IngenierIa de Sistemas y TeorIa de la Senal, Universidad de Alicante, Apartado 99, E-03080 Alicante (Spain); Arribas, Enrique, E-mail: a.belendez@ua.es [Departamento de Fisica Aplicada, Escuela Superior de IngenierIa Informatica, Universidad de Castilla-La Mancha, Avda de Espana, s/n, E-02071 Albacete (Spain)

2011-09-15

An approximate scheme for obtaining the period of a simple pendulum for large-amplitude oscillations is analysed and discussed. When students express the exact frequency or the period of a simple pendulum as a function of the oscillation amplitude, and they are told to expand this function in a Taylor series, they always do so using the oscillation amplitude as the variable, without considering that if they change the variable (in this paper to the new variable m), a different Taylor series expansion may be performed which is in addition more accurate than previously published ones. Students tend to believe that there is one and only one way of performing a Taylor series expansion of a specific function. The approximate analytical formula for the period is obtained by means of a Taylor expansion of the exact frequency taking into account the Kidd-Fogg formula for the period. This approach based on the Taylor expansion of the frequency about a suitable value converges quickly even for large amplitudes. We believe that this method may be very useful for teaching undergraduate courses on classical mechanics and helping students understand nonlinear oscillations of a simple pendulum.

A numerical study of three-dimensional bubble merger in the Rayleigh endash Taylor instability

International Nuclear Information System (INIS)

Li, X.L.

1996-01-01

The Rayleigh endash Taylor instability arises when a heavy fluid adjacent to a light fluid is accelerated in a direction against the density gradient. Under this unstable configuration, a perturbation mode of small amplitude grows into bubbles of the light fluid and spikes of the heavy fluid. Taylor discovered the steady state motion with constant velocity for a single bubble or periodic bubbles in the Rayleigh endash Taylor instability. Read and Youngs studied the motion of a randomly perturbed fluid interface in the Rayleigh endash Taylor instability. They reported constant acceleration for the overall bubble envelope. Bubble merger is believed to cause the transition from constant velocity to constant acceleration. In this paper, we present a numerical study of this important physical phenomenon. It analyzes the physical process of bubble merger and the relationship between the horizontal bubble expansion and the vertical interface acceleration. A dynamic bubble velocity, beyond Taylor close-quote s steady state value, is observed during the merger process. It is believed that this velocity is due to the superposition of the bubble velocity with a secondary subharmonic unstable mode. The numerical results are compared with experiments. copyright 1996 American Institute of Physics

Advection and Taylor-Aris dispersion in rivulet flow

Science.gov (United States)

Al Mukahal, F. H. H.; Duffy, B. R.; Wilson, S. K.

2017-11-01

Motivated by the need for a better understanding of the transport of solutes in microfluidic flows with free surfaces, the advection and dispersion of a passive solute in steady unidirectional flow of a thin uniform rivulet on an inclined planar substrate driven by gravity and/or a uniform longitudinal surface shear stress are analysed. Firstly, we describe the short-time advection of both an initially semi-infinite and an initially finite slug of solute of uniform concentration. Secondly, we describe the long-time Taylor-Aris dispersion of an initially finite slug of solute. In particular, we obtain the general expression for the effective diffusivity for Taylor-Aris dispersion in such a rivulet, and discuss in detail its different interpretations in the special case of a rivulet on a vertical substrate.

Constructions of legitimacy: the Charles Taylor trial

NARCIS (Netherlands)

Glasius, M.; Meijers, T.

2012-01-01

This article examines the discourses of the prosecution and the defence in the case of Charles Taylor before the Special Court for Sierra Leone. It contributes to current debates about the legitimacy and utility of international criminal justice, which have tended to neglect the examination of

The Rayleigh–Taylor Instability Among the Stars

Indian Academy of Sciences (India)

The Rayleigh–Taylor Instability Among the Stars. Rajaram Nityananda. Rajaram Nityananda works at the School of Liberal. Studies, Azim Premji. University, Bengaluru. Earlier, he spent a decade at the National Centre for Radio. Astrophysics in Pune, and more than two decades at the. Raman Research Institute in.

Mode transition in bubbly Taylor-Couette flow measured by PTV

International Nuclear Information System (INIS)

Yoshida, K; Tasaka, Y; Murai, Y; Takeda, T

2009-01-01

The drag acting to the inner cylinder in Taylor-Couette flow system can be reduced by bubble injection. In this research, relationship between drag reduction and change of vortical structure in a Taylor-Couette flow is investigated by Particle Tracking Velocimetry (PTV). The velocity vector field in the r-z cross section and the bubble concentration in the front view (z-θ plane) are measured. This paper describes the change of vortical structures with bubbles, and the mode transition that is sensitively affected by the bubbles is discussed. The bubbles accumulate in the three parts relative to vortex position by the interaction between bubbles and vortices. The status of bubble's distribution is different depending on position. This difference affects mode transition as its trigger significantly. The presence of bubbles affects the transition from toroidal mode to spiral mode but does not induce the transition from spiral mode to toroidal mode. Further we found that Taylor vortex bifurcates and a pair of vortices coalesces when the flow switches between spiral mode and toroidal mode.

Theoretical and numerical studies of Rayleigh-Taylor instabilities in magnetized plasmas; Etude theorique et numerique des instabilites Rayleigh-Taylor en plasmas magnetises

Energy Technology Data Exchange (ETDEWEB)

Ivanov, A.A

2001-06-01

The instabilities of Rayleigh-Taylor type are considered in the thesis. The topic of the thesis was inspired by recent advances in the physics of plasma compression, especially with the aid of systems like Z-pinch. Rayleigh-Taylor instability (RTI) plays an important role in the evolution of magnetized plasmas in these experiments, as well as in stellar plasmas and classic fluids. For the phenomena concerning the nuclear fusion the RTI is very often the factor limiting the possibility of compression. In the current work we try to examine in detail the characteristic features of the instabilities of this type in order to eliminate their detrimental influence. In this thesis we are studying both the general case of the 'classic' Rayleigh-Taylor instability (in incompressible fluids) and more specific cases of the instabilities of Rayleigh-Taylor type in magnetized plasmas, in the liners or wire array implosions etc. We have studied the influence of the Hall diffusion of magnetic field on the growth rate of the instability. We have obtained in this work a self-similar solution for the widening of the initial profile of the magnetic field and for the wave of the penetration of magnetic field. After that the subsequent evolution of the magnetic field in plasma opening switches (POS) has been examined. We have shown the possibility of the existence of a strong rarefaction wave for collisional and non-collisional cases. This wave can explain the phenomenon of the opening of POS. The effect of the suppression of Rayleigh-Taylor instability by forced oscillations of the boundary between two fluids permits us to propose some ideas for the experiments of inertial fusion. We have considered the general case of the instability, in other words, two incompressible viscous superposed fluids in a gravitational field. We have obtained an exact analytical expression for the growth rate and then we have analyzed the influence of the parameters of external &apos

Disentangling the origins of torque enhancement through wall roughness in Taylor-Couette turbulence

NARCIS (Netherlands)

Zhu, Xiaojue; Verzicco, Roberto; Lohse, Detlef

2017-01-01

Direct numerical simulations (DNS) are performed to analyse the global transport properties of turbulent Taylor-Couette flow with inner rough wall up to Taylor number Ta = 1010. The dimensionless torque Nuω shows an effective scaling of Nuω ∝ Ta0.42±0.01, which is steeper than the ultimate regime

Successful collaboration in healthcare-a guide for physicians, nurses and clinical documentation specialists

DEFF Research Database (Denmark)

Larsen, Torben

2010-01-01

methods of economic evaluation are relevant for a societal evaluation of the usefulness of an intervention. Sticking to DRG subtleties, only, the guidance serves private hospital profit instead of societal benefit. In all, these are serious weaknesses for a book aiming to guide the collaboration between......Book review Successful collaboration in healthcare-a guide for physicians, nurses and clinical documentation specialists Colleen Stukenberg New York: CRC Press, Taylor & Francis Group, 2010, pp. 136 ISBN 978 1 4389 1292 1 This book addresses an important topic, especially for health professionals...... engaged in integrated care (IC). Also, the book is easy to read with about 120 pages in a fluent language that you feel is based on first hand personal job experiences. Colleen Stukenberg is a certified nurse with more than 20 years' experience from a variety of hospital areas, a master's of science...

A Taylor weak-statement algorithm for hyperbolic conservation laws

Science.gov (United States)

Baker, A. J.; Kim, J. W.

1987-01-01

Finite element analysis, applied to computational fluid dynamics (CFD) problem classes, presents a formal procedure for establishing the ingredients of a discrete approximation numerical solution algorithm. A classical Galerkin weak-statement formulation, formed on a Taylor series extension of the conservation law system, is developed herein that embeds a set of parameters eligible for constraint according to specification of suitable norms. The derived family of Taylor weak statements is shown to contain, as special cases, over one dozen independently derived CFD algorithms published over the past several decades for the high speed flow problem class. A theoretical analysis is completed that facilitates direct qualitative comparisons. Numerical results for definitive linear and nonlinear test problems permit direct quantitative performance comparisons.

Influence of velocity shear on the Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Guzdar, P.N.; Satyanarayana, P.; Huba, J.D.; Ossakow, S.L.

1982-01-01

The influence of a transverse velocity shear on the Rayleigh-Taylor instability is investigated. It is found that a sheared velocity flow can substantially reduce the growth rate of the Rayleigh-Taylor instability in short wavelength regime (i.e., kL>1 where L is the scale length of the density inhomogeneity), and causes the growth rate to maximize at kL<1.0. Applications of this result to ionospheric phenomena [equatorial spread F (ESF) and ionospheric plasma clouds] are discussed. In particular, the effect of shear could account for, at times, the 100's of km modulation observed on the bottomside of the ESF ionosphere and the km scale size wavelengths observed in barium cloud prompt striation phenomena

Quality control of the NPL-CRC secondary standard system used for activimeters calibration at IPEN, Sao Paulo, Brazil;Ccontrole de qualidade do sistema padrao secundario NPL-CRC utilizado na calibracao de ativimetros no IPEN

Energy Technology Data Exchange (ETDEWEB)

Martins, Elaine W.; Potiens, Maria da P.A. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2009-07-01

The objective of this study was to establish a quality control program to be applied at the NPL-CRC activimeter secondary standard system, used as reference to comparison in tests made with the work tertiary standard activimeter, Capintec basic CRC{sup R}-15BT, both belonging to the Calibration Laboratory of IPEN. The repeatability, reproducibility and the precision tests were performed using a sealed check source of {sup 133}Ba, from Amersham. It was made 70 series of 10 measurements to each activimeter, totaling 1400 measurements. Considering the variation limit of 5% to precision and reproducibility tests in the nuclear medicine services, recommended by the Brazilian standard CNEN-NN-3.05, the results observed in the behavior of the IPEN activimeter were satisfactory. (author)

Taylor Series-Based Long-Term Creep-Life Prediction of Alloy 617

International Nuclear Information System (INIS)

Yin, Song Nan; Kim, Woo Gon; Kim, Yong Wan; Park, Jae Young; Kim, Soen Jin

2010-01-01

In this study, a Taylor series (T-S) model based on the Arrhenius, McVetty, and Monkman-Grant equations was developed using a mathematical analysis. In order to reduce fitting errors, the McVetty equation was transformed by considering the first three terms of the Taylor series equation. The model parameters were accurately determined by a statistical technique of maximum likelihood estimation, and this model was applied to the creep data of alloy 617. The T-S model results showed better agreement with the experimental data than other models such as the Eno, exponential, and L-M models. In particular, the T-S model was converted into an isothermal Taylor series (IT-S) model that can predict the creep strength at a given temperature. It was identified that the estimations obtained using the converted ITS model was better than that obtained using the T-S model for predicting the long-term creep life of alloy 617

Normalization of the parameterized Courant-Snyder matrix for symplectic factorization of a parameterized Taylor map

International Nuclear Information System (INIS)

Yan, Y.T.

1991-01-01

The transverse motion of charged particles in a circular accelerator can be well represented by a one-turn high-order Taylor map. For particles without energy deviation, the one-turn Taylor map is a 4-dimensional polynomials of four variables. The four variables are the transverse canonical coordinates and their conjugate momenta. To include the energy deviation (off-momentum) effects, the map has to be parameterized with a smallness factor representing the off-momentum and so the Taylor map becomes a 4-dimensional polynomials of five variables. It is for this type of parameterized Taylor map that a mehtod is presented for converting it into a parameterized Dragt-Finn factorization map. Parameterized nonlinear normal form and parameterized kick factorization can thus be obtained with suitable modification of the existing technique

Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients.

Science.gov (United States)

Tsoi, H; Lam, K C; Dong, Y; Zhang, X; Lee, C K; Zhang, J; Ng, S C; Ng, S S M; Zheng, S; Chen, Y; Fang, J; Yu, J

2017-11-02

One characteristic of cancer cells is the abnormally high rate of cell metabolism to sustain their enhanced proliferation. However, the behind mechanism of this phenomenon is still elusive. Here we find that enhanced precursor 45s ribosomal RNA (pre-45s rRNA) is one of the core mechanisms in promoting the pathogenesis of colorectal cancer (CRC). Pre-45s rRNA expression is significantly higher in primary CRC tumor tissues samples and cancer cell lines compared with the non-tumorous colon tissues, and is associated with tumor sizes. Knockdown of pre-45s rRNA inhibits G1/S cell-cycle transition by stabilizing p53 through inducing murine double minute 2 (MDM2) and ribosomal protein L11 (RpL11) interaction. In addition, we revealed that high rate of cancer cell metabolism triggers the passive release of calcium ion from endoplasmic reticulum to the cytoplasm. The elevated calcium ion in the cytoplasm activates the signaling cascade of calcium/calmodulin-dependent protein kinase II, ribosomal S6 kinase (S6K) and ribosomal S6K (CaMKII-S6K-UBF). The activated UBF promotes the transcription of rDNA, which therefore increases pre-45s rRNA. Disruption of CaMKII-S6K-UBF axis by either RNAi or pharmaceutical approaches leads to reduction of pre-45s rRNA expression, which subsequently suppresses cell proliferation in colon cancer cells by causing cell-cycle arrest. Knockdown of APC activates CaMKII-S6K-UBF cascade and thus enhances pre-45s rRNA expression. Moreover, the high expression level of pre-45s rRNA is associated with poor survival of CRC patients in two independent cohorts. Our study identifies a novel mechanism in CRC pathogenesis mediated by pre-45s rRNA and a prognostic factor of pre-45s rRNA in CRC patients.

Irregular wall roughness in turbulent Taylor-Couette flow

Science.gov (United States)

Berghout, Pieter; Zhu, Xiaojue; Verzicco, Roberto; Lohse, Detlef; Stevens, Richard

2017-11-01

Many wall bounded flows in nature, engineering and transport are affected by surface roughness. Often, this has adverse effects, e.g. drag increase leading to higher energy costs. A major difficulty is the infinite number of roughness geometries, which makes it impossible to systematically investigate all possibilities. Here we present Direct Numerical Simulations (DNS) of turbulent Taylor-Couette flow. We focus on the transitionally rough regime, in which both viscous and pressure forces contribute to the total wall stress. We investigate the effect of the mean roughness height and the effective slope on the roughness function, ΔU+ . Also, we present simulations of varying Ta (Re) numbers for a constant mean roughness height (kmean+). Alongside, we show the behavior of the large scale structures (e.g. plume ejection, Taylor rolls) and flow structures in the vicinity of the wall.

The New UN CRC General Comment 13: "The Right of the Child to Freedom from All Forms of Violence"--Changing How the World Conceptualizes Child Protection

Science.gov (United States)

Svevo-Cianci, Kimberly A.; Herczog, Maria; Krappmann, Lothar; Cook, Philip

2011-01-01

The UN Committee on the Rights of the Child established CRC General Comment 13 (April 2011) to address today's unabating high rates of violence against children globally despite CRC advances. GC13 provides clear interpretations and stronger detail to supplement the legal language of CRC Article 19, intended to establish protection of children from…

A depositional model for the Taylor coal bed, Martin and Johnson counties, eastern Kentucky

Science.gov (United States)

Andrews, W.M.; Hower, J.C.; Ferm, J.C.; Evans, S.D.; Sirek, N.S.; Warrell, M.; Eble, C.F.

1996-01-01

This study investigated the Taylor coal bed in Johnson and Martin counties, eastern Kentucky, using field and petrographic techniques to develop a depositional model of the coal bed. Petrography and chemistry of the coal bed were examined. Multiple benches of the Taylor coal bed were correlated over a 10 km distance. Three sites were studied in detail. The coal at the western and eastern sites were relatively thin and split by thick clastic partings. The coal at the central site was the thickest and unsplit. Two major clastic partings are included in the coal bed. Each represents a separate and distinct fluvial splay. The Taylor is interpreted to have developed on a coastal plain with periodic flooding from nearby, structurally-controlled fluvial systems. Doming is unlikely due to the petrographic and chemical trends, which are inconsistent with modern Indonesian models. The depositional history and structural and stratigraphic setting suggest contemporaneous structural influence on thickness and quality of the Taylor coal bed in this area.

The simultaneous onset and interaction of Taylor and Dean instabilities in a Couette geometry

International Nuclear Information System (INIS)

Hills, C P; Bassom, A P

2005-01-01

The fluid flow between a pair of coaxial circular cylinders generated by the uniform rotation of the inner cylinder and an azimuthal pressure gradient is susceptible to both Taylor and Dean type instabilities. The flow can be characterised by two parameters: a measure of the relative magnitude of the rotation and pressure effects and a non-dimensional Taylor number. Neutral curves associated with each instability can be constructed but it has been suggested that these curves do not cross but rather posses 'kinks'. Our work is based in the small gap, large wavenumber limit and considers the simultaneous onset of Taylor and Dean instabilities. The two linear instabilities interact at exponentially small orders and a consistent, matched asymptotic solution is found across the whole annular domain, identifying five regions of interest: two boundary adjustment regions and three internal critical points. We construct necessary conditions for the concurrent onset of the linear Taylor and Dean instabilities and show that neutral curve crossing is possible

Concentration of circulating miRNA-containing particles in serum enhances miRNA detection and reflects CRC tissue-related deregulations.

Science.gov (United States)

ElSharawy, Abdou; Röder, Christian; Becker, Thomas; Habermann, Jens K; Schreiber, Stefan; Rosenstiel, Philip; Kalthoff, Holger

2016-11-15

The emerging potential of miRNAs as biomarkers for cancer detection demands parallel evaluation of strategies for reliable identification of disease-related signatures from easily accessible and pertinent body compartments. Here, we addressed whether efficient concentration of circulating miRNA-carrying particles is a rationale for miRNA biomarker discovery. We systematically compared miRNA signatures in 93 RNA preparations from three serum entities (whole serum, particle-concentrated, and particle-depleted fractions) and corresponding tissue samples from patients with colorectal cancer (CRC) as a model disease. Significant differences between whole sera and particle-concentrated serum fractions of CRC patients emerged for 45 of 742 tested miRNAs. Twenty-eight of these 45 miRNAs were differentially expressed between particle-concentrated serum fractions of metastatic CRC- and healthy individuals. Over half of these candidates (15 of 28) showed deregulations only in concentrated serum fractions, but not in whole sera, compared to the respective controls.Our results also provided evidence of a consistent downregulation of miR-486 and miR-92a, and further showed a possible "strand-specific" deregulation of extracellular miRNAs in CRC. More importantly, most of the identified miRNAs in the enriched sera reflected the patterns of the corresponding tumor tissues and showed links to cancer-related inflammation. Further investigation of seven serum pools revealed a subset of potential extracellular miRNA candidates to be implicated in both neoplastic and inflammatory bowel disease.Our findings demonstrate that enrichment and sensitive detection of miRNA carriers is a promising approach to detect CRC-related pathological changes in liquid biopsies, and has potential for clinical diagnostics.

76 FR 24479 - In the Matter of the Taylor Lumber and Treating Superfund Site, Sheridan, Oregon, Amendment to...

Science.gov (United States)

2011-05-02

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9300-9] In the Matter of the Taylor Lumber and Treating... Taylor Lumber and Treating Site, which PWPO was acquiring, in exchange for several obligations related to...-553- 0705. Comments should reference the Taylor Lumber and Treating Superfund Site in Sheridan, Oregon...

The Mantle and Basalt-Crust Interaction Below the Mount Taylor Volcanic Field, New Mexico

Science.gov (United States)

Schrader, Christian M.; Crumpler, Larry S.; Schmidt, Marick E.

2010-01-01

The Mount Taylor Volcanic Field (MTVF) lies on the Jemez Lineament on the southeastern margin of the Colorado Plateau. The field is centered on the Mt. Taylor composite volcano and includes Mesa Chivato to the NE and Grants Ridge to the WSW. MTVF magmatism spans approximately 3.8-1.5 Ma (K-Ar). Magmas are dominantly alkaline with mafic compositions ranging from basanite to hy-basalt and felsic compositions ranging from ne-trachyte to rhyolite. We are investigating the state of the mantle and the spatial and temporal variation in basalt-crustal interaction below the MTVF by examining mantle xenoliths and basalts in the context of new mapping and future Ar-Ar dating. The earliest dated magmatism in the field is a basanite flow south of Mt. Taylor. Mantle xenolith-bearing alkali basalts and basanites occur on Mesa Chivato and in the region of Mt. Taylor, though most basalts are peripheral to the main cone. Xenolith-bearing magmatism persists at least into the early stages of conebuilding. Preliminary examination of the mantle xenolith suite suggests it is dominantly lherzolitic but contains likely examples of both melt-depleted (harzburgitic) and melt-enriched (clinopyroxenitic) mantle. There are aphyric and crystal-poor hawaiites, some of which are hy-normative, on and near Mt. Taylor, but many of the more evolved MTVF basalts show evidence of complex histories. Mt. Taylor basalts higher in the cone-building sequence contain >40% zoned plagioclase pheno- and megacrysts. Other basalts peripheral to Mt. Taylor and at Grants Ridge contain clinopyroxene and plagioclase megacrysts and cumulate-textured xenoliths, suggesting they interacted with lower crustal cumulates. Among the questions we are addressing: What was the chemical and thermal state of the mantle recorded by the basaltic suites and xenoliths and how did it change with time? Are multiple parental basalts (Si-saturated vs. undersaturated) represented and, if so, what changes in the mantle or in the tectonic

Evidence of Rayleigh-Taylor instabilities in tri-layer targets

International Nuclear Information System (INIS)

Galmiche, D.; Holstein, P.A.; Meyer, B.; Rostaing, M.; Wilke, N.

1988-01-01

The results of the experiments carried out on a laser system are reported. The work is performed in order to investigate the problem of target instability under ablative acceleration and to get direct evidence of Rayleigh-Taylor instabilities. Tri-layer experiments assert the validity of X-ray spectroscopy measurements as experimental method to investigate the problem. A mixing zone is evidenced and general trends of mixing development versus target acceleration are coherent with numerical simulations. Results obtained with optical smoothing demonstrate that the apparent mixing is not due to large scale illumination non uniformities. Numerical simulations confirm that Rayleigh-Taylor instability seems to be the dominant process responsible for the mixing. Benefit of time resolved spectroscopy appears attractive and gives a real knowledge of the mixing layer

75 FR 42281 - Continuation of the National Emergency With Respect To the Former Liberian Regime of Charles Taylor

Science.gov (United States)

2010-07-21

... National Emergency With Respect To the Former Liberian Regime of Charles Taylor On July 22, 2004, by... Taylor, pursuant to the International Emergency Economic Powers Act (50 U.S.C. 1701-1706). The President... States constituted by the actions and policies of former Liberian President Charles Taylor and other...

Ruptured peroneal aneurysm after infrapopliteal prosthetic bypass with Taylor patch

Directory of Open Access Journals (Sweden)

Florian Enzmann

Full Text Available Introduction: A 45-year-old mailman underwent an implantation of a femoro-peroneal polytetrafluoroethylene (PTFE bypass with a distal Taylor patch six years prior to admission after two failed autologous reconstructions and extensive fasciotomy. The initial pathology was an acute ischemia due to popliteal entrapment with subsequent popliteal thrombectomy. Report: The patient was examined because of pain, reduction of walking distance and development of a palpable mass at the medial fasciotomy site. A 6-cm pseudoaneurysm with complete disruption of the suture line of the vein patch was discovered and resected. Arterial continuity with a vein interposition graft was established using non-reversed cephalic vein. Conclusion: The etiology of the aneurysm is not entirely clear. One may argue that the fourth revascularization could have been performed with an arm vein instead of a prosthetic graft with the probability of a better long term patency in a young patient. 15 months after the procedure the bypass is patent and the patient is without any symptoms. This complication of a Taylor patch has not been reported before. Keywords: Taylor patch, Pseudoaneurysm, Infrapopliteal bypass

Taylor bubbles at high viscosity ratios: experiments and numerical simulations

Science.gov (United States)

Hewakandamby, Buddhika; Hasan, Abbas; Azzopardi, Barry; Xie, Zhihua; Pain, Chris; Matar, Omar

2015-11-01

The Taylor bubble is a single long bubble which nearly fills the entire cross section of a liquid-filled circular tube, often occurring in gas-liquid slug flows in many industrial applications, particularly oil and gas production. The objective of this study is to investigate the fluid dynamics of three-dimensional Taylor bubble rising in highly viscous silicone oil in a vertical pipe. An adaptive unstructured mesh modelling framework is adopted here which can modify and adapt anisotropic unstructured meshes to better represent the underlying physics of bubble rising and reduce computational effort without sacrificing accuracy. The numerical framework consists of a mixed control volume and finite element formulation, a `volume of fluid'-type method for the interface-capturing based on a compressive control volume advection method, and a force-balanced algorithm for the surface tension implementation. Experimental results for the Taylor bubble shape and rise velocity are presented, together with numerical results for the dynamics of the bubbles. A comparison of the simulation predictions with experimental data available in the literature is also presented to demonstrate the capabilities of our numerical method. EPSRC Programme Grant, MEMPHIS, EP/K0039761/1.

Editorial: Howard Taylor Ricketts

Directory of Open Access Journals (Sweden)

Facultad de Medicina Revista

1941-05-01

Full Text Available Howard Taylor Ricketts nació en Findlay (Ohio el 9 de febrero de 1871. Pasó su niñez en Nebraska, recibió su título de bachiller en la Universidad de ese Estado, en 1894 y se graduó de médico en Northwestern University, en 1897. Hizo su internado en el Cook-County de Chicago. Practicó estdios especiales de dermatología en el Rush Medical College durante dos años. En 1900 contrajo matrimonio con Myra Tubbs, inteligente mujer que colaboró en sus trabajos con rara devoción, ardiente interés y constante estímulo.

Spread F bubbles - Nonlinear Rayleigh-Taylor mode in two dimensions

Science.gov (United States)

Hudson, M. K.

1978-01-01

The paper discusses long-wavelength developed bottomside spread F which has been attributed to the Rayleigh-Taylor instability. The nonlinear saturation amplitude and the k spectrum of the inertia-dominated Rayleigh-Taylor instability is found in two directions: east-west and vertical. As in the collisional case (Chaturvedi and Ossakow, 1977), the dominant nonlinearity is found to be two-dimensional. It is found that the linearly most unstable modes, which are primarily horizontal, saturate by the nonlinear generation of vertical spatial harmonics. The harmonics are damped by diffusion or recombination. The resulting amplitude spectrum indicates that bubbles are vertically elongated in both inertial and collisional regimes.

Observation of Rayleigh-Taylor-like structures in a laser-accelerated foil

International Nuclear Information System (INIS)

Whitlock, R.R.; Emery, M.H.; Stamper, J.A.; McLean, E.A.; Obenschain, S.P.; Peckerar, M.C.

1984-01-01

Laser-accelerated targets have been predicted to be subject to the Rayleigh-Taylor hydrodynamic instability. The development of the instability was studied by introducing mass thickness variations in foil targets and observing the development of the target nonuniformities by side-on flash x radiography. Observations were made of target structures and mass redistribution effects which resemble Rayleigh-Taylor bubbles and spikes, including not only advanced broadening of the spike tips on the laser-irradiated side of the foil but also projections of mass on the unirradiated side. The observations compare well with numerical simulations

78 FR 43751 - Continuation of the National Emergency With Respect to the Former Liberian Regime of Charles Taylor

Science.gov (United States)

2013-07-19

... National Emergency With Respect to the Former Liberian Regime of Charles Taylor On July 22, 2004, by... regime of Charles Taylor pursuant to the International Emergency Economic Powers Act (50 U.S.C. 1701-1706... constituted by the actions and policies of former Liberian President Charles Taylor and other persons, in...

Wall Shear Rates in Taylor Vortex Flow

Czech Academy of Sciences Publication Activity Database

Sobolík, V.; Jirout, T.; Havlica, Jaromír; Kristiawan, M.

2011-01-01

Roč. 4, č. 3 (2011), s. 25-31 ISSN 1735-3572 Grant - others:ANR:(FR) ANR-08-BLAN-0184-01 Institutional research plan: CEZ:AV0Z40720504 Keywords : taylor-couette flow * electrodiffusion diagnostics * membrane reactors Subject RIV: CI - Industrial Chemistry, Chemical Engineering http://www.jafmonline.net/modules/journal/journal_browse.php?EJjid=13

Rayleigh-Taylor mixing with time-dependent acceleration

Science.gov (United States)

Abarzhi, Snezhana

2016-10-01

We extend the momentum model to describe Rayleigh-Taylor (RT) mixing driven by a time-dependent acceleration. The acceleration is a power-law function of time, similarly to astrophysical and plasma fusion applications. In RT flow the dynamics of a fluid parcel is driven by a balance per unit mass of the rates of momentum gain and loss. We find analytical solutions in the cases of balanced and imbalanced gains and losses, and identify their dependence on the acceleration exponent. The existence is shown of two typical regimes of self-similar RT mixing-acceleration-driven Rayleigh-Taylor-type and dissipation-driven Richtymer-Meshkov-type with the latter being in general non-universal. Possible scenarios are proposed for transitions from the balanced dynamics to the imbalanced self-similar dynamics. Scaling and correlations properties of RT mixing are studied on the basis of dimensional analysis. Departures are outlined of RT dynamics with time-dependent acceleration from canonical cases of homogeneous turbulence as well as blast waves with first and second kind self-similarity. The work is supported by the US National Science Foundation.

76 FR 43799 - Continuation of the National Emergency With Respect to the Former Liberian Regime of Charles Taylor

Science.gov (United States)

2011-07-21

...--Continuation of the National Emergency With Respect to the Former Liberian Regime of Charles Taylor #0; #0; #0... Continuation of the National Emergency With Respect to the Former Liberian Regime of Charles Taylor On July 22... of Charles Taylor, pursuant to the International Emergency Economic Powers Act (50 U.S.C. 1701-1706...

Performance of continuously reinforced concrete pavements volume 5 : maintenance and repair of CRC pavements.

Science.gov (United States)

1998-10-01

This report is one of a series of reports prepared as part of a recent study sponsored by the Federal Highway Administration (FHWA) aimed at updating the state-of-the-art of the design, construction, maintenance, and rehabiilitation of CRC pavements....

Boundary effects and the onset of Taylor vortices

Science.gov (United States)

Rucklidge, A. M.; Champneys, A. R.

2004-05-01

It is well established that the onset of spatially periodic vortex states in the Taylor-Couette flow between rotating cylinders occurs at the value of Reynolds number predicted by local bifurcation theory. However, the symmetry breaking induced by the top and bottom plates means that the true situation should be a disconnected pitchfork. Indeed, experiments have shown that the fold on the disconnected branch can occur at more than double the Reynolds number of onset. This leads to an apparent contradiction: why should Taylor vortices set in so sharply at the Reynolds number predicted by the symmetric theory, given such large symmetry-breaking effects caused by the boundary conditions? This paper offers a generic explanation. The details are worked out using a Swift-Hohenberg pattern formation model that shares the same qualitative features as the Taylor-Couette flow. Onset occurs via a wall mode whose exponential tail penetrates further into the bulk of the domain as the driving parameter increases. In a large domain of length L, we show that the wall mode creates significant amplitude in the centre at parameter values that are O( L-2) away from the value of onset in the problem with ideal boundary conditions. We explain this as being due to a Hamiltonian Hopf bifurcation in space, which occurs at the same parameter value as the pitchfork bifurcation of the temporal dynamics. The disconnected anomalous branch remains O(1) away from the onset parameter since it does not arise as a bifurcation from the wall mode.

Identification of Dynamic Loads Based on Second-Order Taylor-Series Expansion Method

OpenAIRE

Li, Xiaowang; Deng, Zhongmin

2016-01-01

A new method based on the second-order Taylor-series expansion is presented to identify the structural dynamic loads in the time domain. This algorithm expresses the response vectors as Taylor-series approximation and then a series of formulas are deduced. As a result, an explicit discrete equation which associates system response, system characteristic, and input excitation together is set up. In a multi-input-multi-output (MIMO) numerical simulation study, sinusoidal excitation and white no...

Search for Rayleigh-Taylor instability in laser irradiated layered thin foil targets

International Nuclear Information System (INIS)

Kilkenny, J.D.; Hares, J.D.; Rumsby, P.T.

1980-01-01

An experiment to measure the Rayleigh-Taylor instability at the vacuum-ablation surface of laser irradiated layered targets by time resolved x-ray spectroscopy is described. The time taken to burn through a layer of material is measured to be the same for massive targets as for thin foil accelerating targets. It is inferred that the thin foil targets might be Rayleigh-Taylor stable despite the values of γtauapproximately equal to15 calculated from classical theory. (author)

Smashing WordPress Themes Making WordPress Beautiful

CERN Document Server

Hedengren, Thord Daniel

2011-01-01

The ultimate guide to WordPress Themes - one of the hottest topics on the web today WordPress is so much more than a blogging platform, and Smashing WordPress Themes teaches readers how to make it look any way they like - from a corporate site, to a photography gallery and moreWordPress is one of the hottest tools on the web today and is used by sites including The New York Times, Rolling Stone, flickr, CNN, NASA and of course Smashing MagazineBeautiful full colour throughout - web designers expect nothing lessSmashing Magazine will fully support this book by by promoting it through their webs

Effect of weak geometrical forcing on the stability of Taylor-vortex flow

International Nuclear Information System (INIS)

Pan Xiaolong; Khayat, Roger E

2008-01-01

Linear stability analysis of fully developed axisymmetric steady and spatially modulated Taylor-Couette flow is carried out in the narrow-gap limit. The inner cylinder is sinusoidally modulated and rotating, while the outer cylinder is straight and at rest. The modulation amplitude is assumed to be small, and the base steady flow is determined using a regular perturbation expansion of the flow field coupled to a variable-step finite-difference scheme. The disturbance flow equations are derived within the framework of Floquet theory and solved using a nonlinear two-point boundary-value approach. In contrast to unforced Taylor-Couette flow, only vortical base flow is possible in the forced case. It is found that the forcing tends to generally destabilize the base flow, especially around the critical point. Both the critical Taylor number and wavenumber are found to decrease essentially linearly with modulation amplitude.

Effect of magnetic field on Rayleigh-Taylor instability of two superposed fluids

International Nuclear Information System (INIS)

Sharma, P K; Tiwari, Anita; Chhajlani, R K

2012-01-01

The effect of two dimensional magnetic field on the Rayleigh-Taylor (R-T) instability in an incompressible plasma is investigated to include simultaneously the effects of suspended particles and the porosity of the medium. The relevant linearized perturbation equations have been solved. The explicit expression of the linear growth rate is obtained in the presence of fixed boundary conditions. A stability criterion for the medium is derived and discussed the Rayleigh Taylor instabilities in different configurations. It is found that the basic Rayleigh-Taylor instability condition is modified by the presence of magnetic field, suspended particles and porosity of the medium. In case of an unstable R-T configuration, the magnetic field has a stabilizing effect on the system. It is also found that the growth rate of an unstable R-T mode decreases with increasing relaxation frequency thereby showing a stabilizing influence on the R-T configuration.

Self reported awareness of child maltreatment among school professionals in Saudi Arabia: impact of CRC ratification.

Science.gov (United States)

AlBuhairan, Fadia S; Inam, Sarah S; AlEissa, Majid A; Noor, Ismail K; Almuneef, Maha A

2011-12-01

The Convention on the Rights of the Child (CRC) was ratified by Saudi Arabia 15 years ago; yet addressing the issue of child maltreatment only began in more recent years. School professionals play a significant role in children's lives, as they spend a great deal of time with them and are hence essential to protecting and identifying those in danger or at risk. The objective of this study is to identify school professional's awareness of child maltreatment and the existing national policies and procedures to examine the extent of efforts made in Saudi Arabia and to activate the roles of schools and school professionals in protecting children from violence and implementation of Article 19 of the CRC. This was a cross-sectional study, where school professionals from randomly selected schools throughout the country were invited to participate in a self-administered questionnaire. A total of 3,777 school professionals participated in the study. Fifty-five percent of professionals had at least 10 years of work experience. A low-level of awareness of child maltreatment was found in about 1/3 of school professionals. Only 1.9% of school professionals had ever attended any sort of specific training on child maltreatment, though 69.3% of those who had not, were willing to attend future training. With regards to awareness of CRC Article 19 or policies and procedures addressing child maltreatment, only 22% reported being aware of it. The majority of school professionals in Saudi Arabia have a low-intermediate level of awareness of child maltreatment, ratification of CRC, and related national policies and procedures, yet most are willing to attend training programs on this subject matter. Efforts need to be made in the country to fill this gap. Copyright © 2011 Elsevier Ltd. All rights reserved.

Reliability, validity and description of timed performance of the Jebsen-Taylor Test in patients with muscular dystrophies.

Science.gov (United States)

Artilheiro, Mariana Cunha; Fávero, Francis Meire; Caromano, Fátima Aparecida; Oliveira, Acary de Souza Bulle; Carvas, Nelson; Voos, Mariana Callil; Sá, Cristina Dos Santos Cardoso de

2017-12-08

The Jebsen-Taylor Test evaluates upper limb function by measuring timed performance on everyday activities. The test is used to assess and monitor the progression of patients with Parkinson disease, cerebral palsy, stroke and brain injury. To analyze the reliability, internal consistency and validity of the Jebsen-Taylor Test in people with Muscular Dystrophy and to describe and classify upper limb timed performance of people with Muscular Dystrophy. Fifty patients with Muscular Dystrophy were assessed. Non-dominant and dominant upper limb performances on the Jebsen-Taylor Test were filmed. Two raters evaluated timed performance for inter-rater reliability analysis. Test-retest reliability was investigated by using intraclass correlation coefficients. Internal consistency was assessed using the Cronbach alpha. Construct validity was conducted by comparing the Jebsen-Taylor Test with the Performance of Upper Limb. The internal consistency of Jebsen-Taylor Test was good (Cronbach's α=0.98). A very high inter-rater reliability (0.903-0.999), except for writing with an Intraclass correlation coefficient of 0.772-1.000. Strong correlations between the Jebsen-Taylor Test and the Performance of Upper Limb Module were found (rho=-0.712). The Jebsen-Taylor Test is a reliable and valid measure of timed performance for people with Muscular Dystrophy. Copyright © 2017 Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia. Publicado por Elsevier Editora Ltda. All rights reserved.

Liz Taylor : minu van Gogh pole natsidele kuulunud

Index Scriptorium Estoniae

2004-01-01

Elizabeth Taylor palus kohtult otsust, et talle kuuluvat 15 miljonit dollarit maksvat Vincent van Goghi maali "Vaade Saint-Remy varjupaigale" pole natsid Margarete Mauthneri juudiperekonna käest vägivaldselt ära võtnud. E. Taylori isa ostis maali 1963. a. Londonis oksjonilt

Taylor vortices in the flow between two coaxial cylinders one of which has a step change in radius

International Nuclear Information System (INIS)

Raju, V R K

2014-01-01

A numerical study of the flow between two coaxial cylinders, where one of the cylinders has a step change in radius, is carried out. The inner cylinder rotates and the outer cylinder is stationary. Computation is restricted to axisymmetric motion since instability in flow between coaxial cylinders is found to first occur in the form of axisymmetric Taylor vortices. In the presence of a step, Taylor vortices are found to appear first in the region where the gap between the cylinders is larger and approximately when the local Taylor number in this region reaches the critical Taylor number for onset of instability. Subsequently, Taylor vortices appear in the region where the gap is narrower, and when the local Taylor number in that region exceeds the critical Taylor number. The Taylor vortices have inward flow at a stationary end plate, and outward flow at an end plate which rotates with the same angular velocity as the inner cylinder. Similar results were obtained by Sprague et al (2008 Phys. Fluids 20 014102) for a step on inner cylinder configuration. The step functions as another end plate, if the step size is large. Whereas, it has no effect, if the step size is small. In most situations, these determine whether the number of Taylor vortices in the wide and narrow gap regions is even or odd. When the end plates rotate synchronously, but at a different speed from the inner cylinder, a change from even to odd or odd to even number of vortices in each region occurs at certain rotation rates of the end plates by sudden appearance or disappearance of a vortex at the end of the column. For a certain range of rotation rates of the end plates, the total number of vortices in the entire fluid column is odd, although the end conditions are symmetrical. (paper)

Risk Management and Simulation

DEFF Research Database (Denmark)

Skovmand, David

2014-01-01

Review of: Risk Management and Simulation / Aparna Gupta. Boca Raton, FL: CRC Press, 2013, xxix + 491 pp., $99.95(H), ISBN: 978-1-4398-3594-4.......Review of: Risk Management and Simulation / Aparna Gupta. Boca Raton, FL: CRC Press, 2013, xxix + 491 pp., $99.95(H), ISBN: 978-1-4398-3594-4....

Predictability of Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Viecelli, J.A.

1986-01-01

Numerical experiments modeling the Rayleigh Taylor instability are carried out using a two-dimensional incompressible Eulerian hydrodynamic code VFTS. The method of integrating the Navier-Stokes equations including the viscous terms is similar to that described in Kim and Moin, except that Lagrange particles have been added and provision for body forces is given. The Eulerian method is 2nd order accurate in both space and time, and the Poisson equation for the effective pressure field is solved exactly at each time step using a cyclic reduction method. 3 refs., 3 figs

RELATIONSHIP BETWEEN COMPACTING PRESSURE AND CONDITIONS IN PRESSING CHAMBER DURING BIOMASS PRESSING

Directory of Open Access Journals (Sweden)

Peter Križan

2016-02-01

Full Text Available In this paper, we will present the impact of the conditions in pressing chambers during the pressing of wooden briquettes. The conditions in pressing chambers can significantly impact the resulting compacting pressure required for the pressing of briquettes. In the introduction, we show which parameters of the pressing chamber during pressing can impact the resulting compacting pressure. The experiment results which are shown in this paper described the detected impact of some important pressing chamber parameters. This experiment aims to detect the pressing chamber length impact and the impact of the way of pressing. By setting the pressing conditions, we will be able to achieve the suitable resulting compacting pressure with respect to the required final briquettes quality.

Taylorism, Tylerism, and Performance Indicators: Defending the Indefensible?

Science.gov (United States)

Helsby, Gill; Saunders, Murray

1993-01-01

Explores the antecedents to the growing interest in the use of educational performance indicators. Discusses this issue in relation to the work of economist F. W. Taylor and evaluator Ralph Tyler. Describes a five-year project that demonstrates the promise of teacher-developed performance indicators. (CFR)

Taylor dispersion of colloidal particles in narrow channels

NARCIS (Netherlands)

Sane, J.; Padding, J.T.; Louis, A.A.

2015-01-01

Special issue in Honor of Jean-Pierre Hansen We use a mesoscopic particle-based simulation technique to study the classic convection-diffusion problem of Taylor dispersion for colloidal discs in confined flow. When the disc diameter becomes non-negligible compared to the diameter of the pipe, there

On the validity of Taylor's hypothesis for wall-bounded flows

International Nuclear Information System (INIS)

Piomelli, U.; Balint, J.; Wallace, J.M.

1989-01-01

The results of large eddy simulation (LES) of the Navier--Stokes equations are used to evaluate the validity of Taylor's hypothesis of frozen turbulence, which states that the time derivative of some instantaneous quantity is proportional to its derivative in the streamwise direction, for incompressible plane channel flow. Time and space derivatives in the streamwise direction of the velocity components are, in fact, found to be well correlated. Root-mean-square fluctuations of the terms in Taylor's hypothesis also support the validity of this hypothesis above the buffer layer. The good agreement between LES and experimental results indicates that errors in the evaluation of derivatives in the streamwise direction are due mostly to insufficient resolution

The safety and efficacy of microwave ablation for the treatment of CRC pulmonary metastases.

Science.gov (United States)

Cheng, Gui; Shi, Liangrong; Qiang, Weiguang; Wu, Jun; Ji, Mei; Lu, Qicheng; Li, Xiaodong; Xu, Bin; Jiang, Jingting; Wu, Changping

2017-11-16

Microwave ablation (MWA) is a recently developed thermal ablation technique that has been used for the treatment of different types of tumours. In the present study, we retrospectively evaluated the safety and efficacy of CT-guided percutaneous MWA for the treatment of colorectal cancer (CRC) pulmonary metastases. From June 2010 to June 2015, 48 unresectable lesions in 32 patients with CRC pulmonary metastases were subjected to CT-guided MWA. Imaging follow-up was with contrast-enhanced CT and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. Oncologic imaging showed that 42 (87.5%) of the 48 lesions in the 32 patients were completely ablated. Needle track metastatic seeding was not found, and no patient deaths occurred within 30 d after ablation. The mean hospital stay was 3 d (range, 2-7 d). Pneumothorax was the most frequent complication and occurred in 6 (12.5%) of the 48 lesions. The median survival time was 31 months (95% CI: 15.4-46.6). The 1-, 2- and 3-year survival rates were 79.5%, 63.1% and 44.4%, respectively. Univariate Cox regression analysis showed that tumour size, disease-free interval (DFI) and number of tumours were significantly related to the overall survival time (p = .007, p = .022 and p = .030, respectively). Multivariate analysis showed that tumour size was an independent prognostic factor for survival (p = .017). CT-guided percutaneous MWA is a safe and effective minimally invasive method for treating CRC pulmonary metastases.

IRRIGATION PRACTICES IN LONG-TERM SURVIVORS OF COLORECTAL CANCER (CRC) WITH COLOSTOMIES

Science.gov (United States)

Grant, Marcia; McMullen, Carmit K.; Altschuler, Andrea; Hornbrook, Mark C.; Herrinton, Lisa J.; Wendel, Christopher S.; Baldwin, Carol M.; Krouse, Robert S.

2014-01-01

Creation of a colostomy in colorectal (CRC) cancer patients results in a loss of control over bowel evacuation. The only way to re-establish some control is through irrigation, a procedure that involves instilling fluid into the bowel to allow for gas and fecal output. This article reports on irrigation practices of participants in a large, multi-site, multi-investigator study of health-related quality of life (HR-QOL) in long term CRC survivors. Questions about irrigation practices were identified in open-ended questions within a large HR-QOL survey and in focus groups of men and women with high and low HR-QOL. Descriptive data on survivors were combined with content analysis of irrigation knowledge and practices. Patient education and use of irrigation in the United States has decreased over the years, with no clear identification of why this change in practice has occurred. Those respondents who used irrigation had their surgery longer ago, and spent more time in colostomy care than those that did not irrigate. Reasons for the decrease in colostomy irrigation are unreported and present priorities for needed research. PMID:23022935

Synchrotron radiation microtomography of Taylor bubbles in capillary two-phase flow

Energy Technology Data Exchange (ETDEWEB)

Boden, Stephan [Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Institute of Fluid Dynamics, P.O. Box 510119, Dresden (Germany); Santos Rolo, Tomy dos; Baumbach, Tilo [Karlsruhe Institute of Technology (KIT), Institute for Photon Science and Synchrotron Radiation (IPS), Eggenstein-Leopoldshafen (Germany); Hampel, Uwe [Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Institute of Fluid Dynamics, P.O. Box 510119, Dresden (Germany); Technische Universitaet Dresden (TUD), AREVA Endowed Chair of Imaging Techniques in Energy and Process Engineering, Dresden (Germany)

2014-07-15

We report on a study to measure the three-dimensional shape of Taylor bubbles in capillaries using synchrotron radiation in conjunction with ultrafast radiographic imaging. Moving Taylor bubbles in 2-mm round and square capillaries were radiographically scanned with an ultrahigh frame rate of up to 36,000 fps and 5.6-μm pixel separation. Consecutive images were properly processed to yield 2D transmission radiographs of high contrast-to-noise ratio. Application of 3D tomographic image reconstruction disclosed the 3D bubble shape. The results provide a reference data base for development of sophisticated interface resolving CFD computations. (orig.)

Synchrotron radiation microtomography of Taylor bubbles in capillary two-phase flow

Science.gov (United States)

Boden, Stephan; dos Santos Rolo, Tomy; Baumbach, Tilo; Hampel, Uwe

2014-07-01

We report on a study to measure the three-dimensional shape of Taylor bubbles in capillaries using synchrotron radiation in conjunction with ultrafast radiographic imaging. Moving Taylor bubbles in 2-mm round and square capillaries were radiographically scanned with an ultrahigh frame rate of up to 36,000 fps and 5.6-µm pixel separation. Consecutive images were properly processed to yield 2D transmission radiographs of high contrast-to-noise ratio. Application of 3D tomographic image reconstruction disclosed the 3D bubble shape. The results provide a reference data base for development of sophisticated interface resolving CFD computations.

Synchrotron radiation microtomography of Taylor bubbles in capillary two-phase flow

International Nuclear Information System (INIS)

Boden, Stephan; Santos Rolo, Tomy dos; Baumbach, Tilo; Hampel, Uwe

2014-01-01

We report on a study to measure the three-dimensional shape of Taylor bubbles in capillaries using synchrotron radiation in conjunction with ultrafast radiographic imaging. Moving Taylor bubbles in 2-mm round and square capillaries were radiographically scanned with an ultrahigh frame rate of up to 36,000 fps and 5.6-μm pixel separation. Consecutive images were properly processed to yield 2D transmission radiographs of high contrast-to-noise ratio. Application of 3D tomographic image reconstruction disclosed the 3D bubble shape. The results provide a reference data base for development of sophisticated interface resolving CFD computations. (orig.)

The Contribution of F.W. Taylor to Industrial and Organizational Psychology

Directory of Open Access Journals (Sweden)

E. C. Thomas

1982-11-01

In die artikel word getoon dat F.W. Taylor die erkende "vader van wetenskaplike bestuur" ook erkenning behoort te geniet as grondlegger van die Bedryf en -organisasiesielkunde. Sy werk op die terreine van prestasiemotivering en tevredenheid, opleiding, plasing van werkers, bestuurs- en organisasieontwikkeling en arbeidsverhoudinge het waarskynlik die werk van erkende sielkundiges op hierdie gebiede vooruitgeloop, of grondslag daarvoor gelê. Daar word tot die slotsom gekom dat alhoewel Taylor nie 'n opgeleide sielkundige was nie, hy en sy kollegas erkenning moet kry vir die praktiese implimentering van die beginsels en teorieë van die moderne Bedryf- en Organisasiesielkunde.

Taylor Series Trajectory Calculations Including Oblateness Effects and Variable Atmospheric Density

Science.gov (United States)

Scott, James R.

2011-01-01

Taylor series integration is implemented in NASA Glenn's Spacecraft N-body Analysis Program, and compared head-to-head with the code's existing 8th- order Runge-Kutta Fehlberg time integration scheme. This paper focuses on trajectory problems that include oblateness and/or variable atmospheric density. Taylor series is shown to be significantly faster and more accurate for oblateness problems up through a 4x4 field, with speedups ranging from a factor of 2 to 13. For problems with variable atmospheric density, speedups average 24 for atmospheric density alone, and average 1.6 to 8.2 when density and oblateness are combined.

Insulin diffusion and self-association characterized by real-time UV imaging and Taylor dispersion analysis

DEFF Research Database (Denmark)

Jensen, Sabrine S; Jensen, Henrik; Cornett, Claus

2014-01-01

, self-association, and apparent size of insulin were further characterized by Taylor dispersion analysis, size exclusion chromatography, and dynamic light scattering. At low insulin concentrations and pH 3.0, the hydrodynamic radius of insulin was determined by Taylor dispersion analysis to 1.5±0.1nm...

Effect of magnetic field on the Rayleigh Taylor instability of rotating and stratified plasma

International Nuclear Information System (INIS)

Sharma, PK; Tiwari, Anita; Argal, Shraddha

2017-01-01

In the present study the effect of magnetic field and rotation have been carried out on the Rayleigh Taylor instability of conducting and rotating plasma, which is assumed to be incompressible and confined between two rigid planes z = 0 and z = h. The dispersion relation of the problem is obtained by solving the basic MHD equations of the problem with the help normal mode technique and appropriate boundary conditions. The dispersion relation of the medium is analysed and the effect of magnetic field and angular velocity (rotation effect) have been examined on the growth rate of Rayleigh Taylor instability. It is found that the magnetic field and angular velocity (rotation effect) have stabilizing influence on the Rayleigh Taylor instability. (paper)

Modeling Taylor series approximations for prompt neutron kinetics with lab view simulations

International Nuclear Information System (INIS)

Adzri, E. P.

2012-09-01

The reactor point kinetics equations have been subjected to intense research in an effort to find simple yet accurate numerical solutions methods. The equations are very stiff numerically, meaning that there is a wide variation in the decay constants, so that using a particular time step in the numerical solution may provide sufficient accuracy for the group, but not for another. Several solutions techniques have been presented on the point kinetics equations with varying degrees of complexity. These include Power Series Solutions, CORE, PCA, Genapol and Taylor series methods. In this research, algorithms were developed based on the first and second order Taylor series expansion and simulated in LabVIEW to solve the Reactor Point Kinetics equations using block diagram nodes implemented within stacked sequences. The algorithms developed were fast,accurate and simple to code. Several reactivity insertions were used to simulate the change in neutron population with time. The LabVIEW- Taylor series solutions were compared with other solution techniques such as Power Series Solutions, CORE, PCA, Genapol and McMahon and Pierson's Taylor series approximation. The results of LabVIEW-Taylor series technique used by McMahon and Pearson The LabVIEW-implemented techniques were found to agree very well with these other methods. At 1x10 -8 s the neutron population was 1.000220 neutrons / cm 3 , at 1 x 10 -2 s it was 2.007681 neutrons / cm 3 and at 1x10 -1 s it was 2.075317 neutrons / cm 3 ; same results reported by Genapol for a fast reactor, it produced good and accurate results and compared very favorably with other methods found in the literature. Using much smaller time steps to the order or 10 -8 s commensurate with fast reactor parameters also produced very satisfactory results, indicating that the LabVIEW-based Taylor series technique is suitable for simulating the kinetics of fast reactors as well as thermal reactors. Algorithms developed that included second order terms

Rayleigh-Taylor mixing with space-dependent acceleration

Science.gov (United States)

Abarzhi, Snezhana

2016-11-01

We extend the momentum model to describe Rayleigh-Taylor (RT) mixing driven by a space-dependent acceleration. The acceleration is a power-law function of space coordinate, similarly to astrophysical and plasma fusion applications. In RT flow the dynamics of a fluid parcel is driven by a balance per unit mass of the rates of momentum gain and loss. We find analytical solutions in the cases of balanced and imbalanced gains and losses, and identify their dependence on the acceleration exponent. The existence is shown of two typical sub-regimes of self-similar RT mixing - the acceleration-driven Rayleigh-Taylor-type mixing and dissipation-driven Richtymer-Meshkov-type mixing with the latter being in general non-universal. Possible scenarios are proposed for transitions from the balanced dynamics to the imbalanced self-similar dynamics. Scaling and correlations properties of RT mixing are studied on the basis of dimensional analysis. Departures are outlined of RT dynamics with space-dependent acceleration from canonical cases of homogeneous turbulence as well as blast waves with first and second kind self-similarity. The work is supported by the US National Science Foundation.

Using Taylor Expansions to Prepare Students for Calculus

Science.gov (United States)

Lutzer, Carl V.

2011-01-01

We propose an alternative to the standard introduction to the derivative. Instead of using limits of difference quotients, students develop Taylor expansions of polynomials. This alternative allows students to develop many of the central ideas about the derivative at an intuitive level, using only skills and concepts from precalculus, and…

Taylor dispersion on a fractal

International Nuclear Information System (INIS)

Mazo, R.M.

1998-01-01

Taylor dispersion is the greatly enhanced diffusion in the direction of a fluid flow caused by ordinary diffusion in directions orthogonal to the flow. It is essential that the system be bounded in space in the directions orthogonal to the flow. We investigate the situation where the medium through which the flow occurs has fractal properties so that diffusion in the orthogonal directions is anomalous and non-Fickian. The effective diffusion in the flow direction remains normal; its width grows proportionally with the time. However, the proportionality constant depends on the fractal dimension of the medium as well as its walk dimension. (author)

Durability Testing of Additively Manufactured High Power Microwave Structures

Science.gov (United States)

2017-10-29

D. Hoffman, B. Singh and J. Thomas, Handbook of vacuum science and technology . San Diego, CA: Academic Press, 1998. [17] M. Cuneo, "The effect of...the higher He diffusion rate through rubber o-rings, its lower pumping speed within the cryopump and possibly saturation of the charcoal arrays...Third Edition, CRC Press (Boca Raton, FL, USA, 2016). [3] J. C. Whitaker, “Power Vacuum Tubes Handbook ”, Second Edition, CRC Press (New York, NY, USA

CD133 expression is not selective for tumor initiating or radioresistant cell populations in the CRC line HCT-116

International Nuclear Information System (INIS)

Seidel, Claudia; Dietrich, Antje; Wondrak, Marit; Kunz-Schughart, Leoni A.; Grade, Marian; Ried, Thomas

2009-01-01

The hypothesis of certain subpopulations of cancer cells with stem-cell like characteristics that might be responsible for treatment resistance and recurrence of disease is still challenging and under quite controversial discussion. In most studies, surrogate cell surface antigens such as the 92-110 kDa transmembrane glycoprotein CD133 (human Prominin-1) were labeled to isolate particular small cancer cell populations for studying their tumorigenic potential. In colorectal carcinomas (CRC) for example, a small CD133 positive (CD133 + ) cell population has recently been described to be enriched for tumor-initiating/cancer stem cells (TIC/CSC) as compared to the CD133 negative (CD133) population. Furthermore, it was documented that the CD133 + subpopulation could exclusively be maintained in culture as spheres under serum-free conditions. Addition of serum resulted in cell differentiation, growth in 2-D and downregulation of CD133 expression. This would imply that established colorectal cancer (CRC) cell lines that have been grown under adherent, serum-supplemented conditions for years should be devoid of CD133 + cells and TIC/CSC, respectively, which seems contradictory to the finding that many CRC lines produce tumors in nude mice models. In order to gain insight into this paradox, we studied the expression of CD133 in numerous established CRC lines under standard culture conditions and chose one particular cell line based on its expression pattern to study the behavior of CD133 + / CD133 - subpopulations

WordPress Bible

CERN Document Server

Brazell, Aaron

2010-01-01

The WordPress Bible provides a complete and thorough guide to the largest self hosted blogging tool. This guide starts by covering the basics of WordPress such as installing and the principles of blogging, marketing and social media interaction, but then quickly ramps the reader up to more intermediate to advanced level topics such as plugins, WordPress Loop, themes and templates, custom fields, caching, security and more. The WordPress Bible is the only complete resource one needs to learning WordPress from beginning to end.

Study of three-dimensional Rayleigh--Taylor instability in compressible fluids through level set method and parallel computation

International Nuclear Information System (INIS)

Li, X.L.

1993-01-01

Computation of three-dimensional (3-D) Rayleigh--Taylor instability in compressible fluids is performed on a MIMD computer. A second-order TVD scheme is applied with a fully parallelized algorithm to the 3-D Euler equations. The computational program is implemented for a 3-D study of bubble evolution in the Rayleigh--Taylor instability with varying bubble aspect ratio and for large-scale simulation of a 3-D random fluid interface. The numerical solution is compared with the experimental results by Taylor

Beryllium-10 in the Taylor Dome ice core: Applications to Antarctic glaciology and paleoclimatology

Energy Technology Data Exchange (ETDEWEB)

Steig, E.J.

1996-12-31

An ice core was drilled at Taylor dome, East Antarctica, reaching to bedrock at 554 meters. Oxygen-isotope measurements reveal climatic fluctuations through the last interglacial period. To facilitate comparison of the Taylor Dome paleoclimate record with geologic data and results from other deep ice cores, several glaciological issues need to be addressed. In particular, accumulation data are necessary as input for numerical ice-flow-models, for determining the flux of chemical constituents from measured concentrations, and for calculation of the offset in age between ice and trapped air in the core. The analysis of cosmogenic beryllium-10 provides a geochemical method for constraining the accumulation-rate history at Taylor Dome. High-resolution measurements were made in shallow firn cores and snow pits to determine the relationship among beryllium-10 concentrations, wet and dry deposition mechanisms, and snow-accumulation rates. Comparison between theoretical and measured variations in deposition over the last 75 years constrains the relationship between beryllium-10 deposition and global average production rates. The results indicate that variations in geomagnetically-modulated production-rate do not strongly influence beryllium-10 deposition at Taylor Dome. Although solar modulation of production rate is important for time scales of years to centuries, snow-accumulation rate is the dominant control on ice-core beryllium-10 concentrations for longer periods. Results show that the Taylor Dome core can be used to provide new constraints on regional climate over the last 130,000 years, complementing the terrestrial and marine geological record from the Dry Valley, Transantarctic Mountains and western Ross Sea.

Measuring Nominal and Real Convergence of Selected CEE Countries by the Taylor Rule

Directory of Open Access Journals (Sweden)

Böing Tobias

2016-12-01

Full Text Available We propose using a simple Taylor rule to evaluate business cycle convergence of the Czech Republic, Hungary, and Poland with the Eurozone. Our findings indicate an ongoing convergence of those CEE countries to the Eurozone, but with instabilities and heterogeneity between the countries. Especially Poland has shown a high degree of convergence in recent years. But there are still relevant differences in Taylor rates of each country to the Eurozone of about two percentage points.

Liquidity Traps with Global Taylor Rules

OpenAIRE

Stephanie Schmitt-Grohe; Martin Uribe

2000-01-01

A key result of a recent literature that focuses on the global consequences of Taylor-type interest rate feedback rules is that such rules, in combination with the zero-bound on nominal interest rates, can lead to unintended liquidity traps. An immediate question posed by this result is whether the government could avoid liquidity traps by ignoring the zero-bound, that is, by threatening to set the nominal interest rate at a negative value should the inflation rate fall below a certain thresh...

Heat transfer characteristics of liquid-gas Taylor flows incorporating microencapsulated phase change materials

International Nuclear Information System (INIS)

Howard, J A; Walsh, P A

2014-01-01

This paper presents an investigation on the heat transfer characteristics associated with liquid-gas Taylor flows in mini channels incorporating microencapsulated phase change materials (MPCM). Taylor flows have been shown to result in heat transfer enhancements due to the fluid recirculation experienced within liquid slugs which is attributable to the alternating liquid slug and gas bubble flow structure. Microencapsulated phase change materials (MPCM) also offer significant potential with increased thermal capacity due to the latent heat required to cause phase change. The primary aim of this work was to examine the overall heat transfer potential associated with combining these two novel liquid cooling technologies. By investigating the local heat transfer characteristics, the augmentation/degradation over single phase liquid cooling was quantified while examining the effects of dimensionless variables, including Reynolds number, liquid slug length and gas void fraction. An experimental test facility was developed which had a heated test section and allowed MPCM-air Taylor flows to be subjected to a constant heat flux boundary condition. Infrared thermography was used to record high resolution experimental wall temperature measurements and determine local heat transfer coefficients from the thermal entrance point. 30.2% mass particle concentration of the MPCM suspension fluid was examined as it provided the maximum latent heat for absorption. Results demonstrate a significant reduction in experimental wall temperatures associated with MPCM-air Taylor flows when compared with the Graetz solution for conventional single phase coolants. Total enhancement in the thermally developed region is observed to be a combination of the individual contributions due to recirculation within the liquid slugs and also absorption of latent heat. Overall, the study highlights the potential heat transfer enhancements that are attainable within heat exchange devices employing MPCM

The Bible and mission in faith perspective: J.Hudson Taylor and the early China Inland Mission

NARCIS (Netherlands)

Wigram, C.E.M.

2007-01-01

The thesis 'The Bible and Mission in Faith Perspective: J.Hudson Taylor and the Early China Inland Mission' by Christopher E.M. Wigram analysis the hermeneutical assumptions that underlay Hudson Taylor's approach to biblical interpretation, and the significance of his approach for the mission which

A crítica de Charles Taylor ao naturalismo na Ciência Política

Directory of Open Access Journals (Sweden)

Tiago Losso

2011-06-01

Full Text Available Os mais recentes esforços de revitalização do enfoque interpretativo na Ciência Política têm sua gênese na década de 1960, quando vários autores passaram a advogar a centralidade do estudo dos significados lingüístico e hermenêutico dos fenômenos políticos. Dentre tais autores, destaca-se o filósofo e politólogo Charles Taylor, cujos textos dos anos 1960 e 1970 desferem críticas contundentes ao naturalismo subjacente ao mainstream da Ciência Política da época. Meu objetivo é explorar a crítica de Taylor ao naturalismo, pensadas no contexto de uma proposta de abordagem interpretativa para a Ciência Política. Primeiramente, contextualizarei as contribuições de Taylor no âmbito mais amplo do interpretive turn nas Ciências Sociais. Em seguida, sumarizarei as reservas que Quentin Skinner e Clifford Geertz apresentam à crítica de Taylor.

Pediatric and adolescent applications of the Taylor Spatial Frame.

Science.gov (United States)

Paloski, Michael; Taylor, Benjamin C; Iobst, Christopher; Pugh, Kevin J

2012-06-01

Limb deformity can occur in the pediatric and adolescent populations from multiple etiologies: congenital, traumatic, posttraumatic sequelae, oncologic, and infection. Correcting these deformities is important for many reasons. Ilizarov popularized external fixation to accomplish this task. Taylor expanded on this by designing an external fixator in 1994 with 6 telescoping struts that can be sequentially manipulated to achieve multiaxial correction of deformity without the need for hinges or operative frame alterations. This frame can be used to correct deformities in children and has shown good anatomic correction with minimal morbidity. The nature of the construct and length of treatment affects psychosocial factors that the surgeon and family must be aware of prior to treatment. An understanding of applications of the Taylor Spatial Frame gives orthopedic surgeons an extra tool to correct simple and complex deformities in pediatric and adolescent patients. Copyright 2012, SLACK Incorporated.

Taylor-Made Education: The Influence of the Efficiency Movement on the Testing of Reading Skills.

Science.gov (United States)

Allen, JoBeth

Much of what has developed in the testing of reading harkens back to the days of the "Cult of Efficiency" movement in education that can be largely attributed to Frederick Winslow Taylor. Taylor spent most of his productive years studying time and motion in an attempt to streamline industrial production so that people could work as…

Rayleigh-Taylor instability in multi-structured spherical targets

International Nuclear Information System (INIS)

Gupta, N.K.; Lawande, S.V.

1986-01-01

An eigenvalue equation for the exponential growth rate of the Rayleigh-Taylor instability is derived in spherical geometry. The free surface and jump boundary conditions are obtained from the eigenvalue equation. The eigenvalue equation is solved in the cases where the initial fluid density profile has a step function or exponential variation in space and analytical formulae for growth rate of the instability are obtained. The solutions for the step function are generalized for any number N of spherical zones forming an arbitrary fluid density profile. The results of the numerical calculations for N spherical zones are compared with the exact analytical results for exponential fluid density profile with N=10 and a good agreement is observed. The formalism is further used to study the effects of density gradients on Rayleigh-Taylor instability in spherical geometry. Also analytical formulae are presented for a particular case of N=3 and shell targets. The formalism developed here can be used to study the growth of the instability in present day multi-structured shell targets. (author)

Nonlinear interaction of Rayleigh--Taylor and shear instabilities

International Nuclear Information System (INIS)

Finn, J.M.

1993-01-01

Results on the nonlinear behavior of the Rayleigh--Taylor instability and consequent development of shear flow by the shear instability [Phys. Fluids B 4, 488 (1992)] are presented. It is found that the shear flow is generated at sufficient amplitude to reduce greatly the convective transport. For high viscosity, the time-asymptotic state consists of an equilibrium with shear flow and vortex flow (with islands, or ''cat's eyes''), or a relaxation oscillation involving an interplay between the shear instability and the Rayleigh--Taylor instability in the presence of shear. For low viscosity, the dominant feature is a high-frequency nonlinear standing wave consisting of convective vortices localized near the top and bottom boundaries. The localization of these vortices is due to the smaller shear near the boundary regions. The convective transport is largest around these convective vortices near the boundary and there is a region of good confinement near the center. The possible relevance of this behavior to the H mode and edge-localized modes (ELM's) in the tokamak edge region is discussed

Taylor Dispersion Analysis as a promising tool for assessment of peptide-peptide interactions

DEFF Research Database (Denmark)

Høgstedt, Ulrich B; Schwach, Grégoire; van de Weert, Marco

2016-01-01

solutions increased with concentration. Our results indicate that a viscosity difference between run buffer and sample in Taylor Dispersion Analysis may result in overestimation of the measured diffusion coefficient. Thus, Taylor Dispersion Analysis provides a practical, but as yet primarily qualitative......Protein-protein and peptide-peptide (self-)interactions are of key importance in understanding the physiochemical behavior of proteins and peptides in solution. However, due to the small size of peptide molecules, characterization of these interactions is more challenging than for proteins...

Autenticitet og kritisk sprogfællesskab hos Charles Taylor

DEFF Research Database (Denmark)

Crone, Manni

2002-01-01

Lever vi i individualistiske samfund, hvor autenticitet og selvrealisering er blevet de højeste værdier? Den canadiske kommunitarist Charles Taylor argumenterer for, at selv om autenticitet og selvrealisering er vigtige værdier for det moderne menneske, kan en excessiv individualisme alligevel...

Surfactants and the Rayleigh-Taylor instability of Couette type flows

Science.gov (United States)

Frenkel, A. L.; Halpern, D.; Schweiger, A. S.

2011-11-01

We study the Rayleigh-Taylor instability of slow Couette- type flows in the presence of insoluble surfactants. It is known that with zero gravity, the surfactant makes the flow unstable to longwave disturbances in certain regions of the parameter space; while in other parametric regions, it reinforces the flow stability (Frenkel and Halpern 2002). Here, we show that in the latter parametric sectors, and when the (gravity) Bond number Bo is below a certain threshold value, the Rayleigh-Taylor instability is completely stabilized for a finite interval of Ma, the (surfactant) Marangoni number: MaL Ma2. For Ma Ma2, and also for MaL Ma2 as functions of the Bond number. We note that (for an interval of the Bond number) there are two distinct criticalities with nonzero (and distinct) critical wavenumbers.

Quantitative investigation of the transition process in Taylor-Couette flow

International Nuclear Information System (INIS)

Tu, Xin Cheng; Kim, Hyoung Bum Kim; Liu, Dong

2013-01-01

The transition process from circular Couette flow to Taylor vortex flow regime was experimentally investigated by measuring the instantaneous velocity vector fields at the annular gap flow region between two concentric cylinders. The proper orthogonal decomposition method, vorticity calculation, and frequency analysis were applied in order to analyze the instantaneous velocity fields to identify the flow characteristics during the transition process. From the results, the kinetic energy and corresponding reconstructed velocity fields were able to detect the onset of the transition process and the alternation of the flow structure. The intermittency and oscillation of the vortex flows during the transition process were also revealed from the analysis of the instantaneous velocity fields. The results can be a measure of identifying the critical Reynolds number of the Taylor-Couette flow from a velocity measurement method.

Clinical utility of the Taylor spatial frame for limb deformities

Directory of Open Access Journals (Sweden)

Keshet D

2017-05-01

Full Text Available Doron Keshet, Mark Eidelman Pediatric Orthopedics Unit, Rambam Health Care Center, Haifa, Israel Abstract: The Taylor spatial frame (TSF is a hexapod external fixator that can correct six-axis deformities. The mathematical base of all hexapod systems is projective geometry, which describes complex repositioning of an object in space. The Taylor brothers developed one of the first six-axis correction systems, which is known today as TSF. Over the years, this system has become the most used six-axis deformity correction device. In this review, we describe the history behind TSF development, and describe the principles and clinical utility for application of the TSF in different settings, such as acute trauma, malunions, and various deformities of the lower and upper limb. Keywords: external fixator, deformity correction, hexapod

Investigation of the Taylor vortices in electrovortex flow

Science.gov (United States)

Vinogradov, D. A.; Ivochkin, Yu P.; Teplyakov, I. O.

2017-10-01

The structure of the electrovortex flow appearing when the electric current passing through the liquid metal interacts with own and external magnetic fields was investigated numerically. It was shown that axial external magnetic field leads to the rotation of the liquid and generates secondary flow similar to Taylor vortex. Calculations were carried out for various ratios of electrode sizes.

Influence of a magnetic field on the Taylor instability in magnetic fluids

International Nuclear Information System (INIS)

Vislovich, A.N.

1986-01-01

The influence of a magnetic field on the stability of Couette flow between rotating cylinders is investigated in the narrow gap approximation. The governing mechanism of the instability is the classical Taylor mechanism. It was shown that rotation of the outer cylinder in the same direction as the inner does not result in a qualitative change in the structure of the theshold perturbations. When the cylinders rotate in different directions in an ordinary fluid, the Taylor vortices develop in the domain of the gap between the inner cylinder and the fluid layer for which v 0 = 0

LASNEX simulations of the classical and laser-driven Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Mikaelian, K.O.

1990-01-01

We present the results of two-dimensional LASNEX simulations of the classical and laser-driven Rayleigh-Taylor instability. Our growth rates and eigenmodes for classical two- and three-fluid problems agree closely with the exact analytic expressions. We illustrate in several examples how perturbations feed through from one interface to another. For targets driven by a 1/4-μm laser at I=2x10 14 W/cm 2 our growth rates are 40--80 % of the classical case rates for wavelengths between 5 and 100 μm. We find that radiation transport has a stabilizing effect on the Rayleigh-Taylor instability, particularly at high intensities. A brief comparison with a laser-driven experiment is also presented

Theoretical and numerical study of Rayleigh-Taylor instabilities in magnetized plasmas; Etude theorique et numerique des instabilites rayleigh-taylor en plasmas magnetises

Energy Technology Data Exchange (ETDEWEB)

Andrei, A. Ivanov

2001-06-15

In this thesis we're studying both the general case of the 'classic' Rayleigh-Taylor instability (in incompressible fluids) and more specific cases of the instabilities of Rayleigh-Taylor type in magnetized plasmas, in the liners or wire array implosions etc. We have studied the influence of the Hall diffusion of magnetic field on the growth rate of the instability. We have obtained in this work a self-similar solution for the widening of the initial profile of the magnetic field and for the wave of the penetration of magnetic field. After that the subsequent evolution of the magnetic field in plasma opening switches (POS) has been examined. We have shown the possibility of the existence of a strong rarefaction wave for collisional and non-collisional cases. This wave can explain the phenomenon of the opening of POS. The effect of the suppression of Rayleigh-Taylor instability by forced oscillations of the boundary between two fluids permits us to propose some ideas for the experiments of inertial fusion. We have considered the general case of the instability, in other words - two incompressible viscous superposed fluids in a gravitational field. We have obtained an exact analytical expression for the growth rate and then we have analyzed the influence of the parameters of external 'pumping' on the instability. These results can be applied to a wide range of systems, starting from classic hydrodynamics and up to astrophysical plasmas. The scheme of wire arrays has become recently a very popular method to obtain a high power X-radiation or for a high quality implosion in Z-pinches. The experimental studies have demonstrated that the results of implosion are much better for the case of multiple thin wires situated cylindrically than in a usual liner scheme. We have examined the problem modeling the stabilization of Rayleigh-Taylor instability for a wire array system. The reason for instability suppression is the regular spatial modulation of

Saffman-Taylor fingers with kinetic undercooling

KAUST Repository

Gardiner, Bennett P. J.

2015-02-23

© 2015 American Physical Society. The mathematical model of a steadily propagating Saffman-Taylor finger in a Hele-Shaw channel has applications to two-dimensional interacting streamer discharges which are aligned in a periodic array. In the streamer context, the relevant regularization on the interface is not provided by surface tension but instead has been postulated to involve a mechanism equivalent to kinetic undercooling, which acts to penalize high velocities and prevent blow-up of the unregularized solution. Previous asymptotic results for the Hele-Shaw finger problem with kinetic undercooling suggest that for a given value of the kinetic undercooling parameter, there is a discrete set of possible finger shapes, each analytic at the nose and occupying a different fraction of the channel width. In the limit in which the kinetic undercooling parameter vanishes, the fraction for each family approaches 1/2, suggesting that this "selection" of 1/2 by kinetic undercooling is qualitatively similar to the well-known analog with surface tension. We treat the numerical problem of computing these Saffman-Taylor fingers with kinetic undercooling, which turns out to be more subtle than the analog with surface tension, since kinetic undercooling permits finger shapes which are corner-free but not analytic. We provide numerical evidence for the selection mechanism by setting up a problem with both kinetic undercooling and surface tension and numerically taking the limit that the surface tension vanishes.

Saffman-Taylor fingers with kinetic undercooling

KAUST Repository

Gardiner, Bennett P. J.; McCue, Scott W.; Dallaston, Michael C.; Moroney, Timothy J.

2015-01-01

© 2015 American Physical Society. The mathematical model of a steadily propagating Saffman-Taylor finger in a Hele-Shaw channel has applications to two-dimensional interacting streamer discharges which are aligned in a periodic array. In the streamer context, the relevant regularization on the interface is not provided by surface tension but instead has been postulated to involve a mechanism equivalent to kinetic undercooling, which acts to penalize high velocities and prevent blow-up of the unregularized solution. Previous asymptotic results for the Hele-Shaw finger problem with kinetic undercooling suggest that for a given value of the kinetic undercooling parameter, there is a discrete set of possible finger shapes, each analytic at the nose and occupying a different fraction of the channel width. In the limit in which the kinetic undercooling parameter vanishes, the fraction for each family approaches 1/2, suggesting that this "selection" of 1/2 by kinetic undercooling is qualitatively similar to the well-known analog with surface tension. We treat the numerical problem of computing these Saffman-Taylor fingers with kinetic undercooling, which turns out to be more subtle than the analog with surface tension, since kinetic undercooling permits finger shapes which are corner-free but not analytic. We provide numerical evidence for the selection mechanism by setting up a problem with both kinetic undercooling and surface tension and numerically taking the limit that the surface tension vanishes.

CRC DEPLETION CALCULATIONS FOR THE NON-RODDED ASSEMBLIES IN BATCHES 8 AND 9 CRYSTAL RIVER UNIT 3

International Nuclear Information System (INIS)

Wilson, Michael L.

2001-01-01

The purpose of this design analysis is to document the SAS2H depletion calculations of certain non-rodded fuel assemblies from batches 8 and 9 of the Crystal River Unit 3 pressurized water reactor (PWR) that are required for Commercial Reactor Critical (CRC) evaluations to support the development of the disposal criticality methodology. A non-rodded assembly is one which never contains a control rod assembly (CRA) or an axial power shaping rod assembly (APSRA) during its irradiation history. The objective of this analysis is to provide SAS2H generated isotopic compositions for each fuel assembly's depleted fuel and depleted burnable poison materials. These SAS2H generated isotopic compositions are acceptable for use in CRC benchmark reactivity calculations containing the various fuel assemblies

Monetary Policy and the Taylor Principle in Open Economies

NARCIS (Netherlands)

Linnemann, L.; Schabert, A.

2006-01-01

Nowadays, central banks mostly conduct monetary policy by setting nominal interest rates. A widely held view is that central banks can stabilize inflation if they follow the Taylor principle, which requires raising the nominal interest rate more than one-for-one in response to higher inflation. Is

Coherent structures in ablatively compressed ICF targets and Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Pant, H.C.; Desai, T.

1996-01-01

One of the major issues in laser induced inertial confinement fusion (ICF) is a stable ablative compression of spherical fusion pellets. The main impediment in achievement of this objective is Rayleigh-Taylor instability at the pellet's ablation front. Under sufficiently high acceleration this instability can grow out of noise. However, it can also arise either due to non-uniform laser intensity distribution over the pellet surface or due to pellet wall areal mass irregularity. Coherent structures in the dense target behind the ablation front can be effectively utilised for stabilisation of the Rayleigh-Taylor phenomenon. Such coherent structures in the form of a super lattice can be created by doping the pellet pusher with high atomic number (Z) micro particles. A compressed-cool pusher under laser irradiation behaves like a strongly correlated non ideal plasma when compressed to sufficiently high density such that the non ideality parameter exceeds unity. Moreover, the nonideality parameter for high Z microinclusions may exceed a critical value of 180 and as a consequence they remain in the form of intact clusters, maintaining the superlattice intact during ablative acceleration. Micro-hetrogeneity and its superlattice plays an important role in stabilization of Rayleigh-Taylor instability, through a variety of mechanisms. (orig.)

WordPress for dummies

CERN Document Server

Sabin-Wilson, Lisa

2014-01-01

The bestselling WordPress guide, fully updated to cover the 2013 enhancements WordPress has millions of users, and this popular guide has sold more than 105,000 copies in its previous editions. With the newest releases of WordPress, author and WordPress expert Lisa Sabin-Wilson has completely updated the book to help you use and understand all the latest features. You'll learn about both the hosted WordPress.com version and the more flexible WordPress.org, which requires third-party hosting. Whether you're switching to WordPress from another blogging platform or just beginning to blog, you'll

Reciprocating pellet press

Science.gov (United States)

Jones, Charles W.

1981-04-07

A machine for pressing loose powder into pellets using a series of reciprocating motions has an interchangeable punch and die as its only accurately machines parts. The machine reciprocates horizontally between powder receiving and pressing positions. It reciprocates vertically to press, strip and release a pellet.

Stochastic model of Rayleigh-Taylor turbulent mixing

International Nuclear Information System (INIS)

Abarzhi, S.I.; Cadjan, M.; Fedotov, S.

2007-01-01

We propose a stochastic model to describe the random character of the dissipation process in Rayleigh-Taylor turbulent mixing. The parameter alpha, used conventionally to characterize the mixing growth-rate, is not a universal constant and is very sensitive to the statistical properties of the dissipation. The ratio between the rates of momentum loss and momentum gain is the statistic invariant and a robust parameter to diagnose with or without turbulent diffusion accounted for

A taylor series approach to survival analysis

International Nuclear Information System (INIS)

Brodsky, J.B.; Groer, P.G.

1984-09-01

A method of survival analysis using hazard functions is developed. The method uses the well known mathematical theory for Taylor Series. Hypothesis tests of the adequacy of many statistical models, including proportional hazards and linear and/or quadratic dose responses, are obtained. A partial analysis of leukemia mortality in the Life Span Study cohort is used as an example. Furthermore, a relatively robust estimation procedure for the proportional hazards model is proposed. (author)

Press Advertising – Varieties and Sub-Varieties. Methods of Promoting the Press

OpenAIRE

Mikosz, Joanna

2016-01-01

In the text entitled “Press advertising – varieties and sub-varieties. Methods of promoting the press”, the author discusses press advertising, which is a fast developing mass-media phenomenon. Modernity has granted press advertising a high quality of print and paper, as well as Infinite possibilities of combining various promotional forms with the press. The author argues that press advertising is one of the best ways in which a company can communicate with the market. Its advantage is, abov...

Finite element analysis and experimental verification of Polymer reinforced CRC improved for close-in detonation

DEFF Research Database (Denmark)

Riisgaard, Benjamin; Georgakis, Christos; Stang, Henrik

2007-01-01

Compact Reinforced Composite, CRC, is a high-strength cement-based composite that holds an enormous flexural and energy-absorbing capacity due to the close-spaced high strength steel reinforcement and a high-strength cement-based fiber DSP matrix. The material has been used in various constructions...

Taylor Law in Wind Energy Data

Directory of Open Access Journals (Sweden)

Rudy Calif

2015-10-01

Full Text Available The Taylor power law (or temporal fluctuation scaling, is a scaling relationship of the form σ ~  (Pλ where !! is the standard deviation and hPi the mean value of a sample of a time series has been observed for power output data sampled at 5 min and 1 s and from five wind farms and a single wind turbine, located at different places. Furthermore, an analogy with the turbulence field is performed, consequently allowing the establishment of a scaling relationship between the turbulent production IP and the mean value (P.

Validity of the Taylor hypothesis for linear kinetic waves in the weakly collisional solar wind

International Nuclear Information System (INIS)

Howes, G. G.; Klein, K. G.; TenBarge, J. M.

2014-01-01

The interpretation of single-point spacecraft measurements of solar wind turbulence is complicated by the fact that the measurements are made in a frame of reference in relative motion with respect to the turbulent plasma. The Taylor hypothesis—that temporal fluctuations measured by a stationary probe in a rapidly flowing fluid are dominated by the advection of spatial structures in the fluid rest frame—is often assumed to simplify the analysis. But measurements of turbulence in upcoming missions, such as Solar Probe Plus, threaten to violate the Taylor hypothesis, either due to slow flow of the plasma with respect to the spacecraft or to the dispersive nature of the plasma fluctuations at small scales. Assuming that the frequency of the turbulent fluctuations is characterized by the frequency of the linear waves supported by the plasma, we evaluate the validity of the Taylor hypothesis for the linear kinetic wave modes in the weakly collisional solar wind. The analysis predicts that a dissipation range of solar wind turbulence supported by whistler waves is likely to violate the Taylor hypothesis, while one supported by kinetic Alfvén waves is not.

HLA-G 3'UTR Polymorphisms Impact the Prognosis of Stage II-III CRC Patients in Fluoropyrimidine-Based Treatment.

Science.gov (United States)

Garziera, Marica; Bidoli, Ettore; Cecchin, Erika; Mini, Enrico; Nobili, Stefania; Lonardi, Sara; Buonadonna, Angela; Errante, Domenico; Pella, Nicoletta; D'Andrea, Mario; De Marchi, Francesco; De Paoli, Antonino; Zanusso, Chiara; De Mattia, Elena; Tassi, Renato; Toffoli, Giuseppe

2015-01-01

An important hallmark of CRC is the evasion of immune surveillance. HLA-G is a negative regulator of host's immune response. Overexpression of HLA-G protein in primary tumour CRC tissues has already been associated to worse prognosis; however a definition of the role of immunogenetic host background is still lacking. Germline polymorphisms in the 3'UTR region of HLA-G influence the magnitude of the protein by modulating HLA-G mRNA stability. Soluble HLA-G has been associated to 3'UTR +2960 Ins/Ins and +3035 C/T (lower levels) and +3187 G/G (high levels) genotypes. HLA-G 3'UTR SNPs have never been explored in CRC outcome. The purpose of this study was to investigate if common HLA-G 3'UTR polymorphisms have an impact on DFS and OS of 253 stage II-III CRC patients, after primary surgery and ADJ-CT based on FL. The 3'UTR was sequenced and SNPs were analyzed for their association with survival by Kaplan-Meier and multivariate Cox models; results underwent internal validation using a resampling method (bootstrap analysis). In a multivariate analysis, we estimated an association with improved DFS in Ins allele (Ins/Del +Ins/Ins) carriers (HR 0.60, 95% CI 0.38-0.93, P = 0.023) and in patients with +3035 C/T genotype (HR 0.51, 95% CI 0.26-0.99, P = 0.045). The +3187 G/G mutated carriers (G/G vs A/A+A/G) were associated to a worst prognosis in both DFS (HR 2.46, 95% CI 1.19-5.05, P = 0.015) and OS (HR 2.71, 95% CI 1.16-6.63, P = 0.022). Our study shows a prognostic and independent role of 3 HLA-G 3'UTR SNPs, +2960 14-bp INDEL, +3035 C>T, and +3187 A>G.

A shift from distal to proximal neoplasia in the colon: a decade of polyps and CRC in Italy

Directory of Open Access Journals (Sweden)

Panzone Sergio

2010-11-01

Full Text Available Abstract Background In the last years a trend towards proximalization of colorectal carcinomas (CRC has been reported. This study aims to evaluate the distribution of CRC and adenomatous polyps (ADP to establish the presence of proximalization and to assess the potential predictors. Methods We retrieved histology reports of colonic specimens excised during colonoscopy, considering the exams performed between 1997 and 2006 at Cuneo Hospital, Italy. We compared the proportion of proximal lesions in the period 1997-2001 and in the period 2002-2006. Results Neoplastic lesions were detected in 3087 people. Proximal CRC moved from 25.9% (1997-2001 to 30.0% (2002-2006. Adjusting for sex and age, the difference was not significant (OR 1.23; 95% CI: 0,95-1,58. The proximal ADP proportion increased from 19.2% (1997-2001 to 26.0% (2002-2006 (OR: 1.43; 95% CI: 1.17-1.89. The corresponding figures for advanced proximal ADP were 6.6% and 9.5% (OR: 1.48; 95% CI: 1.02-2.17. Adjusting for gender, age, diagnostic period, symptoms and number of polyps the prevalence of proximal advanced ADP was increased among people ≥ 70 years compared to those aged 55-69 years (OR 1.49; 95% CI: 1.032.16. The main predictor of proximal advanced neoplasia was the number of polyps detected per exam (> 1 polyp versus 1 polyp: considering all ADP: OR 2.16; 95% CI: 1.59-2.93; considering advanced ADP OR 1.63; 95% CI: 1.08-2.46. Adjusting for these factors, the difference between the two periods was no longer significant. Conclusions CRC do not proximalize while a trend towards a proximal shift in adenomas was observed among people ≥ 70 years.

Traveling waves in a magnetized Taylor-Couette flow

International Nuclear Information System (INIS)

Liu Wei; Ji Hantao; Goodman, Jeremy

2007-01-01

We investigate numerically a traveling wave pattern observed in experimental magnetized Taylor-Couette flow at low magnetic Reynolds number. By accurately modeling viscous and magnetic boundaries in all directions, we reproduce the experimentally measured wave patterns and their amplitudes. Contrary to previous claims, the waves are shown to be transiently amplified disturbances launched by viscous boundary layers, rather than globally unstable magnetorotational modes

Theoretical and numerical studies of Rayleigh-Taylor instabilities in magnetized plasmas

International Nuclear Information System (INIS)

Ivanov, A.A.

2001-06-01

The instabilities of Rayleigh-Taylor type are considered in the thesis. The topic of the thesis was inspired by recent advances in the physics of plasma compression, especially with the aid of systems like Z-pinch. Rayleigh-Taylor instability (RTI) plays an important role in the evolution of magnetized plasmas in these experiments, as well as in stellar plasmas and classic fluids. For the phenomena concerning the nuclear fusion the RTI is very often the factor limiting the possibility of compression. In the current work we try to examine in detail the characteristic features of the instabilities of this type in order to eliminate their detrimental influence. In this thesis we are studying both the general case of the 'classic' Rayleigh-Taylor instability (in incompressible fluids) and more specific cases of the instabilities of Rayleigh-Taylor type in magnetized plasmas, in the liners or wire array implosions etc. We have studied the influence of the Hall diffusion of magnetic field on the growth rate of the instability. We have obtained in this work a self-similar solution for the widening of the initial profile of the magnetic field and for the wave of the penetration of magnetic field. After that the subsequent evolution of the magnetic field in plasma opening switches (POS) has been examined. We have shown the possibility of the existence of a strong rarefaction wave for collisional and non-collisional cases. This wave can explain the phenomenon of the opening of POS. The effect of the suppression of Rayleigh-Taylor instability by forced oscillations of the boundary between two fluids permits us to propose some ideas for the experiments of inertial fusion. We have considered the general case of the instability, in other words, two incompressible viscous superposed fluids in a gravitational field. We have obtained an exact analytical expression for the growth rate and then we have analyzed the influence of the parameters of external 'pumping' on the instability

Development of Rayleigh-Taylor and bulk convection instabilities in the dynamics of plasma liners and pinches

International Nuclear Information System (INIS)

Bud'ko, A.B.; Velikovich, A.L.; Liberman, M.A.; Felber, F.S.

1989-01-01

A solution is derived for the problem of the initial, linear stage of the growth of small perturbations in the course of the cylindrically symmetric compression and expansion of a plasma liner and a Z-pinch with a sharp boundary. In these systems, Rayleigh-Taylor instabilities localized near the plasma boundaries are the most dangerous. Bulk convective instabilities develop in addition to these Rayleigh-Taylor instabilities. The various instability modes, including local and global Rayleigh-Taylor modes, which grown in an accelerated plasma with distributed profiles of hydrodynamic variables, are classified. The spectra of the instability growth rates are calculated for plasma liners and Z-pinches. The shape of these spectra reveals an explanation of the stratification and filamentation of the plasma observed experimentally in pinches and liners. The imposition of a longitudinal magnetic field gives rise to a stability window in the space of the flow parameters. In this window, the Rayleigh-Taylor modes are suppressed completely by magnetic shear, while the bulk convective modes are suppressed to a significant extent

Effect of magnetic field on Rayleigh-Taylor instability of quantum and stratified plasma in porous medium

International Nuclear Information System (INIS)

Sharma, P.K.; Tiwari, Anita; Argal, Shraddha; Chhajlani, R.K.

2013-01-01

This paper is devoted to an investigation of Quantum effects and magnetic field effects on the Rayleigh Taylor instability of two superposed incompressible fluids in bounded porous medium. The Quantum magneto hydrodynamic equations are solved by using normal mode method and a dispersion relation is obtained. The dispersion relation is derived for the case where plasma is bounded by two rigid planes z = 0 and z = h. The Rayleigh Taylor instability growth rate and stability condition of the medium is discussed in the presence of quantum effect, magnetic field, porosity and permeability. It is found that the magnetic field and medium porosity have stabilizing influence while permeability has destabilizing influence on the Rayleigh Taylor instability. (author)

From Taylor to Drucker: Management and Managing

OpenAIRE

Primoz Turk

2008-01-01

The article discusses the question of management and managing, focusing on the changes which took place in the period from Taylor to Drucker. In this period two turning points dramatically changed the nature of management. Management which started within the organization was at first concerned with the organization’s inner workings. This concern with the organization’s ‘inside’ is gradually projected to the outside, to society as a whole. Simultaneously, changes occur in managing. Managing wh...

Liquidity Trap and Stability of Taylor Rules

OpenAIRE

Le Riche , Antoine; Magris , Francesco; Parent , Antoine

2016-01-01

We study a productive economy with fractional cash-in-advance constraint on consumption expenditures. Government issues safe bonds and levies taxes to finance public expenditures, while the Central Bank follows a feedback Taylor rules by pegging the nominal interest rate. We show that when the nominal interest rate is bound to be non-negative, under active policy rules a Liquidity Trap steady state does emerge besides the Leeper (1991) equilibrium. The stability of the two steady states depen...

Status of the Olympus experiment at CRC

Science.gov (United States)

Rogers, David V.

1992-01-01

The status of the Olympus Propagation Experiment of the Communications Research Centre in Ottawa, Canada, is briefly summarized. Path attenuation measurements at multiple frequencies correlated with concurrent dual polarized radar data provide a unique method to investigate propagation effects. An experiment of this type is being implemented by the Communications Research Centre (CRC) on the grounds of the National Research Council of Canada in Ottawa. Beacon receivers monitor signals from the Olympus satellite at 12.5, 19.77, and 29.66 GHz at a path elevation angle of 14.2 deg. Sky noise radiometers operating near the same frequencies and pointed along the same path provide additional propagation information. A colocated dual-polarized 9.6-GHz radar probes the precipitation state on the path, permitting identification of precipitation regimes that cause the observed impairments. The Olympus experiment configuration is displayed pictorially. Information on path propagation phenomena can be deduced by correlating the radar, beacon, and sky noise data. Melting layer effects and propagation losses for higher time percentages are prime interests. Data collected by Diversitel Communications during equipment verification tests are presented.

Direct numerical simulations of type Ia supernovae flames II: The Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Bell, J.B.; Day, M.S.; Rendleman, C.A.; Woosley, S.E.; Zingale, M.

2004-01-01

A Type Ia supernova explosion likely begins as a nuclear runaway near the center of a carbon-oxygen white dwarf. The outward propagating flame is unstable to the Landau-Darrieus, Rayleigh-Taylor, and Kelvin-Helmholtz instabilities, which serve to accelerate it to a large fraction of the speed of sound. We investigate the Rayleigh-Taylor unstable flame at the transition from the flamelet regime to the distributed-burning regime, around densities of 10e7 gm/cc, through detailed, fully resolved simulations. A low Mach number, adaptive mesh hydrodynamics code is used to achieve the necessary resolution and long time scales. As the density is varied, we see a fundamental change in the character of the burning--at the low end of the density range the Rayleigh-Taylor instability dominates the burning, whereas at the high end the burning suppresses the instability. In all cases, significant acceleration of the flame is observed, limited only by the size of the domain we are able to study. We discuss the implications of these results on the potential for a deflagration to detonation transition

WordPress For Dummies

CERN Document Server

Sabin-Wilson, Lisa

2011-01-01

The bestselling guide to WordPress, fully updated to help you get your blog going! Millions of bloggers rely on WordPress, the popular, free blogging platform. This guide covers all the features and improvements in the most up-to-date version of WordPress. Whether you are switching to WordPress from another blogging platform or just starting your first blog, you'll find the advice in this friendly guide gets you up to speed on both the free-hosted WordPress.com version and WordPress.org, which requires the purchase of web hosting services, and figure out which version is best for you. You'll b

Measurement of the Rayleigh-Taylor instability in targets driven by optically smoothed laser beams

International Nuclear Information System (INIS)

Desselberger, M.; Willi, O.; Savage, M.; Lamb, M.J.

1990-01-01

Growth rates of the Rayleigh-Taylor instability were measured in targets with imposed sinusoidal modulations irradiated by optically smoothed 0.53-μm laser beams. A hybrid optical smoothing technique utilizing induced-spatial-incoherence and random-phase-plate technology was used for the first time. The wave-number dependence and the nonlinear behavior of Rayleigh-Taylor growth were investigated by using targets with a range of modulation periodicities and depths. The results are compared to 2D hydrodynamic-code simulations

The carbon stable isotope biogeochemistry of streams, Taylor Valley, Antarctica

International Nuclear Information System (INIS)

Lyons, W.B.; Leslie, D.L.; Harmon, R.S.; Neumann, K.; Welch, K.A.; Bisson, K.M.; McKnight, D.M.

2013-01-01

Highlights: ► δ 13 C-DIC reported from McMurdo Dry Valleys, Antarctica, streams. ► Stream water δ 13 C PDB values range −9.4‰ to +5.1‰, largely inorganic in character. ► Atmospheric exchange is the dominant control on δ 13 C-DIC. - Abstract: The McMurdo Dry Valleys region of Antarctica is the largest ice-free region on the continent. This study reports the first C stable isotope measurements for dissolved inorganic C present in ephemeral streams in four dry valleys that flow for four to twelve weeks during the austral summer. One of these valleys, Taylor Valley, has been the focus of the McMurdo Dry Valleys Long-Term Ecological Research (MCM-LTER) program since 1993. Within Taylor Valley, numerous ephemeral streams deliver water to three perennially ice-covered, closed-basin lakes: Lake Fryxell, Lake Hoare, and Lake Bonney. The Onyx River in the Wright Valley, the longest river in Antarctica, flows for 40 km from the Wright Lower Glacier and Lake Brownworth at the foot of the glacier to Lake Vanda. Streamflow in the McMurdo Dry Valley streams is produced primarily from glacial melt, as there is no overland flow. However, hyporheic zone exchange can be a major hydrogeochemical process in these streams. Depending on landscape position, these streams vary in gradient, channel substrate, biomass abundance, and hyporheic zone extent. This study sampled streams from Taylor, Wright, Garwood, and Miers Valleys and conducted diurnal sampling of two streams of different character in Taylor Valley. In addition, transect sampling was undertaken of the Onyx River in Wright Valley. The δ 13 C PDB values from these streams span a range of greater than 14‰, from −9.4‰ to +5.1‰, with the majority of samples falling between −3‰ and +2‰, suggesting that the C stable isotope composition of dissolved C in McMurdo Dry Valley streams is largely inorganic in character. Because there are no vascular plants on this landscape and no groundwater input to these

Parametric modulation in the Taylor-Couette ferrofluid flow

International Nuclear Information System (INIS)

Singh, Jitender; Bajaj, Renu

2008-01-01

A parametric instability of the Taylor-Couette ferrofluid flow excited by a periodically oscillating magnetic field, has been investigated numerically. The Floquet analysis has been employed. It has been found that the modulation of the applied magnetic field affects the stability of the basic flow. The instability response has been found to be synchronous with respect to the frequency of periodically oscillating magnetic field.

Rayleigh-Taylor instability in an equal mass plasma

Energy Technology Data Exchange (ETDEWEB)

Adak, Ashish, E-mail: ashish-adak@yahoo.com [Department of Instrumentation Science, Jadavpur University, Kolkata 700 032 (India); Ghosh, Samiran, E-mail: sran-g@yahoo.com [Department of Applied Mathematics, University of Calcutta 92, Acharya Prafulla Chandra Road, Kolkata 700 009 (India); Chakrabarti, Nikhil, E-mail: nikhil.chakrabarti@saha.ac.in [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064 (India)

2014-09-15

The Rayleigh-Taylor (RT) instability in an inhomogeneous pair-ion plasma has been analyzed. Considering two fluid model for two species of ions (positive and negative), we obtain the possibility of the existence of RT instability. The growth rate of the RT instability as usual depends on gravity and density gradient scale length. The results are discussed in context of pair-ion plasma experiments.

Taylor-expansion Monte Carlo simulations of classical fluids in the canonical and grand canonical ensemble

International Nuclear Information System (INIS)

Schoen, M.

1995-01-01

In this article the Taylor-expansion method is introduced by which Monte Carlo (MC) simulations in the canonical ensemble can be speeded up significantly, Substantial gains in computational speed of 20-40% over conventional implementations of the MC technique are obtained over a wide range of densities in homogeneous bulk phases. The basic philosophy behind the Taylor-expansion method is a division of the neighborhood of each atom (or molecule) into three different spatial zones. Interactions between atoms belonging to each zone are treated at different levels of computational sophistication. For example, only interactions between atoms belonging to the primary zone immediately surrounding an atom are treated explicitly before and after displacement. The change in the configurational energy contribution from secondary-zone interactions is obtained from the first-order term of a Taylor expansion of the configurational energy in terms of the displacement vector d. Interactions with atoms in the tertiary zone adjacent to the secondary zone are neglected throughout. The Taylor-expansion method is not restricted to the canonical ensemble but may be employed to enhance computational efficiency of MC simulations in other ensembles as well. This is demonstrated for grand canonical ensemble MC simulations of an inhomogeneous fluid which can be performed essentially on a modern personal computer

Quality control of the NPL-CRC secondary standard system used for activimeters calibration at IPEN, Sao Paulo, Brazil

International Nuclear Information System (INIS)

Martins, Elaine W.; Potiens, Maria da P.A.

2009-01-01

The objective of this study was to establish a quality control program to be applied at the NPL-CRC activimeter secondary standard system, used as reference to comparison in tests made with the work tertiary standard activimeter, Capintec basic CRC R -15BT, both belonging to the Calibration Laboratory of IPEN. The repeatability, reproducibility and the precision tests were performed using a sealed check source of 133 Ba, from Amersham. It was made 70 series of 10 measurements to each activimeter, totaling 1400 measurements. Considering the variation limit of 5% to precision and reproducibility tests in the nuclear medicine services, recommended by the Brazilian standard CNEN-NN-3.05, the results observed in the behavior of the IPEN activimeter were satisfactory. (author)

CRC DEPLETION CALCULATIONS FOR THE NON-RODDED ASSEMBLIES IN BATCHES 4 AND 5 OF CRYSTAL RIVER UNIT 3

International Nuclear Information System (INIS)

Wright, Kenneth D.

1997-01-01

The purpose of this design analysis is to document the SAS2H depletion calculations of certain non-rodded fuel assemblies from batches 4 and 5 of the Crystal River Unit 3 pressurized water reactor (PWR) that are required for commercial Reactor Critical (CRC) evaluations to support the development of the disposal criticality methodology. A non-rodded assembly is one which never contains a control rod assembly (CRA) or an axial power shaping rod assembly (APSRA) during its irradiation history. The objective of this analysis is to provide SAS2H generated isotopic compositions for each fuel assembly's depleted fuel and depleted burnable poison materials. These SAS2H generated isotopic compositions are acceptable for use in CRC benchmark reactivity calculations containing the various fuel assemblies

WordPress Bible

CERN Document Server

Brazell, Aaron

2011-01-01

Get the latest word on the biggest self-hosted blogging tool on the marketWithin a week of the announcement of WordPress 3.0, it had been downloaded over a million times. Now you can get on the bandwagon of this popular open-source blogging tool with WordPress Bible, 2nd Edition. Whether you're a casual blogger or programming pro, this comprehensive guide covers the latest version of WordPress, from the basics through advanced application development. If you want to thoroughly learn WordPress, this is the book you need to succeed.Explores the principles of blogging, marketing, and social media

Inward propagating chemical waves in Taylor vortices.

Science.gov (United States)

Thompson, Barnaby W; Novak, Jan; Wilson, Mark C T; Britton, Melanie M; Taylor, Annette F

2010-04-01

Advection-reaction-diffusion (ARD) waves in the Belousov-Zhabotinsky reaction in steady Taylor-Couette vortices have been visualized using magnetic-resonance imaging and simulated using an adapted Oregonator model. We show how propagating wave behavior depends on the ratio of advective, chemical and diffusive time scales. In simulations, inward propagating spiral flamelets are observed at high Damköhler number (Da). At low Da, the reaction distributes itself over several vortices and then propagates inwards as contracting ring pulses--also observed experimentally.

Taylor Principle Supplements the Fisher Effect: Empirical Investigation under the US Context

Directory of Open Access Journals (Sweden)

Mohammed Saiful ISLAM

2012-06-01

Full Text Available This paper reviews the short- and long-run dynamics of interest rate and inflation of the United States. Basing upon quarterly as well as monthly data over the period 1957 to 2010, we find evidence that interest rate behaviour of the Federal Reserve is consistent with the Taylor principle in short run and with the Fisher hypothesis in long run. Entire sample justifies the existence of a long run cointegrating relationship between federal funds rate and inflation characterised as the Fisher effect. When data are split into different subsamples, the cointegrating relationship disappears. Interest rate dynamics of pre-1980 and post-2001 neither track Fisher hypothesis nor Taylor principle, rather represent substantial discretion.

Identità e riconoscimento in Charles Taylor

Directory of Open Access Journals (Sweden)

Francesca Caputo

2013-06-01

Full Text Available The model of the politic of difference, proposed by Charles Taylor, in the wake of a conception of liberalism ‘hospitable’, unfolds in a journey aimed to comply with the ontological dimensions of the dignity of different cultures, of cultural traditions and ways of life. Being a self, constructed in terms of dialogue and dialectic of mutual recognition between cultures, refers, in the Charles Taylor’s reflection, to the safeguarding of single, intersubjective or common meanings of specific social, moral, narrative spaces.

Hydromagnetic Rayleigh-Taylor instability in cylindrical implosions

International Nuclear Information System (INIS)

Hwang, C.S.; Roderick, N.F.; Wu, M.W.

1986-01-01

Rayleigh-Taylor Instability in the (r,Θ) plane has been solved by the variational approach. Results are compared to the analytical solutions of two-region and three-region problems at the infinite radius. They show the magnetic stabilization effect. Growth rates in this plane are decreased by the effects of plasma shell thickness, plasma shell radius, magnetic tension, magnetic diffusion and finite density gradient of the plasma magnetic field interface. The most unstable mode number decreases when the radius of the plasma shell decreases

The solution of the point kinetics equations via converged accelerated Taylor series (CATS)

Energy Technology Data Exchange (ETDEWEB)

Ganapol, B.; Picca, P. [Dept. of Aerospace and Mechanical Engineering, Univ. of Arizona (United States); Previti, A.; Mostacci, D. [Laboratorio di Montecuccolino, Alma Mater Studiorum - Universita di Bologna (Italy)

2012-07-01

This paper deals with finding accurate solutions of the point kinetics equations including non-linear feedback, in a fast, efficient and straightforward way. A truncated Taylor series is coupled to continuous analytical continuation to provide the recurrence relations to solve the ordinary differential equations of point kinetics. Non-linear (Wynn-epsilon) and linear (Romberg) convergence accelerations are employed to provide highly accurate results for the evaluation of Taylor series expansions and extrapolated values of neutron and precursor densities at desired edits. The proposed Converged Accelerated Taylor Series, or CATS, algorithm automatically performs successive mesh refinements until the desired accuracy is obtained, making use of the intermediate results for converged initial values at each interval. Numerical performance is evaluated using case studies available from the literature. Nearly perfect agreement is found with the literature results generally considered most accurate. Benchmark quality results are reported for several cases of interest including step, ramp, zigzag and sinusoidal prescribed insertions and insertions with adiabatic Doppler feedback. A larger than usual (9) number of digits is included to encourage honest benchmarking. The benchmark is then applied to the enhanced piecewise constant algorithm (EPCA) currently being developed by the second author. (authors)

News/Press Releases

Data.gov (United States)

Office of Personnel Management — A press release, news release, media release, press statement is written communication directed at members of the news media for the purpose of announcing programs...

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

Science.gov (United States)

Hammoudi, Abeer; Song, Fei; Reed, Karen R; Jenkins, Rosalind E; Meniel, Valerie S; Watson, Alastair J M; Pritchard, D Mark; Clarke, Alan R; Jenkins, John R

2013-10-25

Colorectal cancer (CRC) is the fourth most common cause of cancer-related death worldwide. Accurate non-invasive screening for CRC would greatly enhance a population's health. Adenomatous polyposis coli (Apc) gene mutations commonly occur in human colorectal adenomas and carcinomas, leading to Wnt signalling pathway activation. Acute conditional transgenic deletion of Apc in murine intestinal epithelium (AhCre(+)Apc(fl)(/)(fl)) causes phenotypic changes similar to those found during colorectal tumourigenesis. This study comprised a proteomic analysis of murine small intestinal epithelial cells following acute Apc deletion to identify proteins that show altered expression during human colorectal carcinogenesis, thus identifying proteins that may prove clinically useful as blood/serum biomarkers of colorectal neoplasia. Eighty-one proteins showed significantly increased expression following iTRAQ analysis, and validation of nine of these by Ingenuity Pathaway Analysis showed they could be detected in blood or serum. Expression was assessed in AhCre(+)Apc(fl)(/)(fl) small intestinal epithelium by immunohistochemistry, western blot and quantitative real-time PCR; increased nucelolin concentrations were also detected in the serum of AhCre(+)Apc(fl)(/)(fl) and Apc(Min)(/)(+) mice by ELISA. Six proteins; heat shock 60kDa protein 1, Nucleolin, Prohibitin, Cytokeratin 18, Ribosomal protein L6 and DEAD (Asp-Glu-Ala-Asp) box polypeptide 5,were selected for further investigation. Increased expression of 4 of these was confirmed in human CRC by qPCR. In conclusion, several novel candidate biomarkers have been identified from analysis of transgenic mice in which the Apc gene was deleted in the intestinal epithelium that also showed increased expression in human CRC. Some of these warrant further investigation as potential serum-based biomarkers of human CRC. Copyright © 2013 Elsevier Inc. All rights reserved.

Pinch instabilities in Taylor-Couette flow.

Science.gov (United States)

Shalybkov, Dima

2006-01-01

The linear stability of the dissipative Taylor-Couette flow with an azimuthal magnetic field is considered. Unlike ideal flows, the magnetic field is a fixed function of a radius with two parameters only: a ratio of inner to outer cylinder radii, eta, and a ratio of the magnetic field values on outer and inner cylinders, muB. The magnetic field with 0rotation. The unstable modes are located into some interval of the axial wave numbers for the flow stable without magnetic field. The interval length is zero for a critical Hartmann number and increases with an increasing Hartmann number. The critical Hartmann numbers and length of the unstable axial wave number intervals are the same for every rotation law. There are the critical Hartmann numbers for m=0 sausage and m=1 kink modes only. The sausage mode is the most unstable mode close to Ha=0 point and the kink mode is the most unstable mode close to the critical Hartmann number. The transition from the sausage instability to the kink instability depends on the Prandtl number Pm and this happens close to one-half of the critical Hartmann number for Pm=1 and close to the critical Hartmann number for Pm=10(-5). The critical Hartmann numbers are smaller for kink modes. The flow stability does not depend on magnetic Prandtl numbers for m=0 mode. The same is true for critical Hartmann numbers for both m=0 and m=1 modes. The typical value of the magnetic field destabilizing the liquid metal Taylor-Couette flow is approximately 10(2) G.

CRC DEPLETION CALCULATIONS FOR THE NON-RODDED ASSEMBLIES IN BATCHES 4 AND 5 OF CRYSTAL RIVER UNIT 3

Energy Technology Data Exchange (ETDEWEB)

Kenneth D. Wright

1997-07-30

The purpose of this design analysis is to document the SAS2H depletion calculations of certain non-rodded fuel assemblies from batches 4 and 5 of the Crystal River Unit 3 pressurized water reactor (PWR) that are required for commercial Reactor Critical (CRC) evaluations to support the development of the disposal criticality methodology. A non-rodded assembly is one which never contains a control rod assembly (CRA) or an axial power shaping rod assembly (APSRA) during its irradiation history. The objective of this analysis is to provide SAS2H generated isotopic compositions for each fuel assembly's depleted fuel and depleted burnable poison materials. These SAS2H generated isotopic compositions are acceptable for use in CRC benchmark reactivity calculations containing the various fuel assemblies.

Head First WordPress

CERN Document Server

Siarto, Jeff

2010-01-01

Whether you're promoting your business or writing about your travel adventures, Head First WordPress will teach you not only how to make your blog look unique and attention-grabbing, but also how to dig into the more complex features of WordPress 3.0 to make your website work well, too. You'll learn how to move beyond the standard WordPress look and feel by customizing your blog with your own URL, templates, plugin functionality, and more. As you learn, you'll be working with real WordPress files: The book's website provides pre-fab WordPress themes to download and work with as you follow al

WordPress multisite administration

CERN Document Server

Longren, Tyler

2013-01-01

This is a simple, concise guide with a step-by-step approach, packed with screenshots and examples to set up and manage a network blog using WordPress.WordPress Multisite Administration is ideal for anyone wanting to familiarize themselves with WordPress Multisite. You'll need to know the basics about WordPress, and having at least a broad understanding of HTML, CSS, and PHP will help, but isn't required.

Life stages of wall-bounded decay of Taylor-Couette turbulence

NARCIS (Netherlands)

Ostilla-Mónico, Rodolfo; Zhu, Xiaojue; Arza, Vamsi Spandan; Verzicco, Roberto; Lohse, Detlef

2017-01-01

The decay of Taylor-Couette turbulence, i.e., the flow between two coaxial and independently rotating cylinders, is numerically studied by instantaneously stopping the forcing from an initially statistically stationary flow field at a Reynolds number of Re=3.5×104. The effect of wall friction is

Evidence for mate guarding behavior in the Taylor's checkerspot butterfly

Science.gov (United States)

Victoria J. Bennett; Winston P. Smith; Matthew G. Betts

2011-01-01

Discerning the intricacies of mating systems in butterflies can be difficult, particularly when multiple mating strategies are employed and are cryptic and not exclusive. We observed the behavior and habitat use of 113 male Taylor's checkerspot butterflies (Euphydryas editha taylori). We confirmed that two distinct mating strategies were...

Horizontally viscous effects in a tidal basin: extending Taylor's problem

NARCIS (Netherlands)

Roos, Pieter C.; Schuttelaars, H.M.

2009-01-01

The classical problem of Taylor (Proc. Lond. Math. Soc., vol. 20, 1921, pp. 148–181) of Kelvin wave reflection in a semi-enclosed rectangular basin of uniform depth is extended to account for horizontally viscous effects. To this end, we add horizontally viscous terms to the hydrodynamic model

The verification of the Taylor-expansion moment method in solving aerosol breakage

Directory of Open Access Journals (Sweden)

Yu Ming-Zhou

2012-01-01

Full Text Available The combination of the method of moment, characterizing the particle population balance, and the computational fluid dynamics has been an emerging research issue in the studies on the aerosol science and on the multiphase flow science. The difficulty of solving the moment equation arises mainly from the closure of some fractal moment variables which appears in the transform from the non-linear integral-differential population balance equation to the moment equations. Within the Taylor-expansion moment method, the breakage-dominated Taylor-expansion moment equation is first derived here when the symmetric fragmentation mechanism is involved. Due to the high efficiency and the high precision, this proposed moment model is expected to become an important tool for solving population balance equations.

Rayleigh-Taylor instability of a self-similar spherical expansion

International Nuclear Information System (INIS)

Bernstein, I.B.; Book, D.L.

1978-01-01

The self-similar motion of a spherically symmetric isentropic cloud of ideal gas driven outward by an expanding low-density medium (e.g., radiation pressure from a pulsar) is shown to be unstable to Rayleigh-Taylor modes which develop in the neighborhood of the interface. A complete solution of the linearized equations of motion is obtained. The implications for astrophysical phenomena are discussed

On stabilization of the Rayleigh-Taylor instability for the imploding liner on account of ion-ion collisions

International Nuclear Information System (INIS)

Gordeev, Alexander V.

2002-01-01

The stabilization of the Rayleigh-Taylor instability for the imploding cylindrical liner in the limit of a low plasma density Π ω pi 2 δ2/c2 << 1 (δ -- the characteristic size of the current layer) is investigated, when the electron currents are much greater than the ion currents. The stabilization of the Rayleigh-Taylor instability for the parameter diapason νii/ωBi < (Z2M/m)1/2 is considered, when the plasma dissipation connected with the ion-ion collisions considerably superior the usual dissipation due to the electron-ion collisions. For the electric conductivity, caused by the ion-ion collisions and resulted in the minimum value σ ∼ enc/B, the effect of the partial stabilization of the Rayleigh-Taylor instability is demonstrated

On the CFD Analysis of a Stratified Taylor-Couette System Dedicated to the Fabrication of Nanosensors

Directory of Open Access Journals (Sweden)

Duccio Griffini

2017-02-01

Full Text Available Since the pioneering work of Taylor, the analysis of flow regimes of incompressible, viscous fluids contained in circular Couette systems with independently rotating cylinders have charmed many researchers. The characteristics of such kind of flows have been considered for some industrial applications. Recently, Taylor-Couette flows found an innovative application in the production of optical fiber nanotips, to be used in molecular biology and medical diagnostic fields. Starting from the activity of Barucci et al., the present work concerns the numerical analysis of a Taylor-Couette system composed by two coaxial counter-rotating cylinders with low aspect ratio and radius ratio, filled with three stratified fluids. An accurate analysis of the flow regimes is performed, considering both the variation of inner and outer rotational speed and the reduction of fiber radius due to etching process. The large variety of individuated flow configurations provides useful information about the possible use of the Taylor-Couette system in a wide range of engineering applications. For the present case, the final objective is to provide accurate information to manufacturers of fiber nanotips about the expected flow regimes, thus helping them in the setup of the control process that will be used to generate high-quality products.

Taylor-Couette fluid flow with force oscillation in the inner-cylinder using the immersed boundary method

Energy Technology Data Exchange (ETDEWEB)

Borges, Jonatas Emmanuel; Lourenco, Marcos Antonio de Souza; Padilla, Elie Luis Martinez; Silveira Neto, Aristeu da [Federal University of Uberlandia , MG (Brazil)], e-mails: lourenco@mecanica.ufu.br, epadilla@mecanica.ufu.br, aristeus@mecanica.ufu.br; Leibsohn, Andre Martins [CENPES/Petrobras, Rio de Janeiro, RJ (Brazil)], e-mail: aleibsohn@petrobras.com

2010-07-01

As new challenges arise in the exploration of deep and ultra-deep water oil fields by PETROBRAS more knowledge and research are needed, so that tools could be developed to assist in the critical operations and make things practicable. In the context of the drilling process, the complexity of the fluid flow inside the riser is associated with the nature of the non-Newtonian flow, immersed solid particles, variable eccentricity and the superimposed traveling azimuthal waves on the inflow and outflow boundaries of the Taylor vortices. This work presents the numerical three-dimensional results of the following simplified fluid flows: Taylor-Couette, Taylor-Couette with varying imposed eccentricity and Taylor-Couette with forced oscillation in the inner cylinder. Using the Navier-Stokes equations, a finite volume method discretization with second order accuracy in both time and space was utilized to simulate the Newtonian, single-phase incompressible fluid flow in the three cases. The circular walls of the inner and outer cylinders are represented by the immersed boundary method, with the direct multi-forcing model. The determined results allow to evidence the flow structures in the three cases in a very qualitative way, even so in the presence of the inner cylinder oscillation. (author)

RADIATIVE RAYLEIGH-TAYLOR INSTABILITIES

International Nuclear Information System (INIS)

Jacquet, Emmanuel; Krumholz, Mark R.

2011-01-01

We perform analytic linear stability analyses of an interface separating two stratified media threaded by a radiation flux, a configuration relevant in several astrophysical contexts. We develop a general framework for analyzing such systems and obtain exact stability conditions in several limiting cases. In the optically thin, isothermal regime, where the discontinuity is chemical in nature (e.g., at the boundary of a radiation pressure-driven H II region), radiation acts as part of an effective gravitational field, and instability arises if the effective gravity per unit volume toward the interface overcomes that away from it. In the optically thick a diabaticregime where the total (gas plus radiation) specific entropy of a Lagrangian fluid element is conserved, for example at the edge of radiation pressure-driven bubble around a young massive star, we show that radiation acts like a modified equation of state and derive a generalized version of the classical Rayleigh-Taylor stability condition.

CRC DEPLETION CALCULATIONS FOR THE NON-RODDED ASSEMBLIES IN BATCHES 1, 2, AND 3 OF CRYSTAL RIVER UNIT 3

International Nuclear Information System (INIS)

Wright, Kenneth D.

1997-01-01

The purpose of this design analysis is to document the SAS2H depletion calculations of certain non-rodded fuel assemblies from batches 1, 2, and 3 of the Crystal River Unit 3 pressurized water reactor (PWR) that are required for Commercial Reactor Critical (CRC) evaluations to support development of the disposal criticality methodology. A non-rodded assembly is one which never contains a control rod assembly (CRA) or an axial power shaping rod assembly (APSRA) during its irradiation history. The objective of this analysis is to provide SAS2H generated isotopic compositions for each fuel assembly's depleted fuel and depleted burnable poison materials. These SAS2H generated isotopic compositions are acceptable for use in CRC benchmark reactivity calculations containing the various fuel assemblies

Taylorism given a helping hand

DEFF Research Database (Denmark)

Tolsby, June

2000-01-01

of the IT system was perceived by some of the employees. Shows how, instead of increasing employees' work engagement, the IT system had the opposite effect. Demonstrates that the new It system contributed to a deskilling of the employees, to a more task-oriented approach to their work, and to increased employees......Illustrates how th implementation of a major information technology (IT) system within the Norwegian Army affected the way the employees perceived their flexibility and personal involvement in their work. By employing Taylor's initial works, this paper illustrates how the introduction......' interdependence. Instead of increasing employees' personal flexibility and involvement in their jobs, the research shows how the new IT system in fact contributed to a reduction in the freedom to choose when and how quickly to do their jobs....

The CRC 20 Years: An Overview of Some of the Major Achievements and Remaining Challenges

Science.gov (United States)

Doek, Jaap E.

2009-01-01

On 20 November 1989, the General Assembly of the United Nations adopted the Convention on the Rights of the Child (CRC). It entered into force on 2 September 1990 and has by now been ratified by 193 States, making the most universally ratified human rights treaty. This overview will present and discuss the impact of this treaty both at the…

Suppression of the Rayleigh-Taylor instability due to self-radiation in a multiablation target

International Nuclear Information System (INIS)

Fujioka, Shinsuke; Sunahara, Atsushi; Nishihara, Katsunobu; Johzaki, Tomoyuki; Shiraga, Hiroyuki; Shigemori, Keisuke; Nakai, Mitsuo; Ikegawa, Tadashi; Murakami, Masakatsu; Nagai, Keiji; Norimatsu, Takayoshi; Azechi, Hiroshi; Yamanaka, Tatsuhiko; Ohnishi, Naofumi

2004-01-01

A scheme to suppress the Rayleigh-Taylor instability has been investigated for a direct-drive inertial fusion target. In a high-Z doped-plastic target, two ablation surfaces are formed separately--one driven by thermal radiation and the other driven by electron conduction. The growth of the Rayleigh-Taylor instability is significantly suppressed on the radiation-driven ablation surface inside the target due to the large ablation velocity and long density scale length. A significant reduction of the growth rate was observed in simulations and experiments using a brominated plastic target. A new direct-drive pellet was designed using this scheme

The Global University Press

Science.gov (United States)

Dougherty, Peter J.

2012-01-01

The modern world's understanding of American university press has long been shaped by university-press books. American university-press books are good international advertisements for the universities whose logos grace their spines. The growth of transnational scholarship and the expansion of digital communications networks are converging in ways…

Local Nusselt number enhancement during gas-liquid Taylor bubble flow in a square mini-channel: An experimental study

International Nuclear Information System (INIS)

Majumder, Abhik; Mehta, Balkrishna; Khandekar, Sameer

2013-01-01

Taylor bubble flow takes place when two immiscible fluids (liquid-liquid or gas-liquid) flow inside a tube of capillary dimensions within specific range of volume flow ratios. In the slug flows where gas and liquid are two different phases, liquid slugs are separated by elongated Taylor bubbles. This singular flow pattern is observed in many engineering mini-/micro-scale devices like pulsating heat pipes, gas-liquid-solid monolithic reactors, micro-two-phase heat exchangers, digital micro-fluidics, micro-scale mass transfer process, fuel cells, etc. The unique and complex flow characteristics require understanding on local, as well as global, spatio-temporal scales. In the present work, the axial stream-wise profile of the fluid and wall temperature for air-water (i) isolated single Taylor bubble and, (ii) a train of Taylor bubbles, in a horizontal square channel of size 3.3 mm x 3.3 mm x 350 mm, heated from the bottom (heated length = 175 mm), with the other three sides kept insulated, are reported at different gas volume flow ratios. The primary aim is to study the enhancement of heat transfer due to the Taylor bubble train flow, in comparison with thermally developing single-phase flows. Intrusion of a bubble in the liquid flow drastically changes the local temperature profiles. The axial distribution of time-averaged local Nusselt number (Nu z ) shows that Taylor bubble train regime increases the transport of heat up to 1.2-1.6 times more as compared with laminar single-phase liquid flow. In addition, for a given liquid flow Reynolds number, the heat transfer enhancement is a function of the geometrical parameters of the unit cell, i.e., the length of adjacent gas bubble and water plug. (authors)

Expression Analysis of Previously Verified Fecal and Plasma Dow-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients.

Science.gov (United States)

Ghanbari, Reza; Rezasoltani, Sama; Hashemi, Javad; Mohamadkhani, Ashraf; Tahmasebifar, Arash; Arefian, Ehsan; Mobarra, Naser; Asadi, Jahanbakhsh; Nazemalhosseini Mojarad, Ehsan; Yazdani, Yaghoub; Knuutila, Sakari; Malekzadeh, Reza

2017-02-01

Colorectal cancer (CRC) is one of the most common causes of cancer-related mortality worldwide. Early diagnosis of this neoplasm is critical and may reduce patients' mortality. MicroRNAs are small non-coding RNA molecules whose expression pattern can be altered in various diseases such as CRC. In this study, we evaluated the expression levels of miR-142-3p, miR-26a-5p (their reduced expression in plasma samples of CRC patients was previously confirmed), miR-4478 and miR-1295-3p (their reduced expression in stool samples of CRC patients was previously confirmed) in tissue samples of CRC patients in comparison to healthy subjects. To achieve this purpose, total RNA including small RNA was extracted from 53 CRC and 35 normal subjects' Formalin-fixed, Paraffin-embedded (FFPE) tissue samples using the miRNeasy FFPE Mini Kit. The expression levels of these four selected miRNAs were measured using quantitative Reverse Transcriptase Polymerase Chain Reaction (qRT-PCR). We found that the expression levels of miR-4478 and miR-1295b-3p (two previously down-regulated fecal miRNAs) were significantly decreased in FFPE samples of CRC patients compared to healthy controls. On the other hand, no significant differences were seen in expression levels of miR-142-3p and miR-26a-5p (two previously down-regulated circulating miRNAs) in FFPE samples between these two groups. Regarding current findings, it may be concluded that to diagnose CRC patients based on the miRNAs approach, stool samples are more likely preferable to plasma samples; nevertheless, additional studies with more samples are needed to confirm the results.

Rayleigh-Taylor instability in a visco-plastic fluid

International Nuclear Information System (INIS)

Demianov, A Yu; Doludenko, A N; Son, E E; Inogamov, N A

2010-01-01

The Rayleigh-Taylor and Richtmyer-Meshkov instabilities of a visco-plastic fluid are discussed. The Bingham model is used as an effective rheological model which takes into account plastic effects. For the purposes of numerical simulation a one-mode disturbance of the contact surface between two fluids is considered. The main goal of this work is to construct numerical 2D and 3D models and to obtain the relationship between yield stress and the development of instability.

Rayleigh-Taylor instability in a visco-plastic fluid

Science.gov (United States)

Demianov, A. Yu; Doludenko, A. N.; Inogamov, N. A.; Son, E. E.

2010-12-01

The Rayleigh-Taylor and Richtmyer-Meshkov instabilities of a visco-plastic fluid are discussed. The Bingham model is used as an effective rheological model which takes into account plastic effects. For the purposes of numerical simulation a one-mode disturbance of the contact surface between two fluids is considered. The main goal of this work is to construct numerical 2D and 3D models and to obtain the relationship between yield stress and the development of instability.

Mixing and axial dispersion in Taylor-Couette flow: experimental and numerical study

International Nuclear Information System (INIS)

Nemri, M.

2013-01-01

Taylor-Couette flows between two concentric cylinders have great potential applications in chemical engineering. They are particularly convenient for two-phase small scale devices enabling solvent extraction operations. An experimental device was designed with this idea in mind. It consists of two concentric cylinders with the inner one rotating and the outer one fixed. Taylor-Couette flows take place in the annular gap between them, and are known to evolve towards turbulence through a sequence of successive instabilities. Macroscopic quantities, such as axial dispersion and mixing index, are extremely sensitive to these flow structures, which may lead to flawed modelling of the coupling between hydrodynamics and mass transfer. This particular point has been studied both experimentally and numerically. The flow and mixing have been characterized by means of flow visualization and simultaneous PIV (Particle Imaging Velocimetry) and PLIF (Planar Laser Induced Fluorescence) measurements. PLIF visualizations showed clear evidences of different transport mechanisms including 'intra-vortex mixing' and 'inter-vortex mixing'. Under WVF and MWVF regimes, intra-vortex mixing is controlled by chaotic advection, due to the 3D nature of the flow, while inter-vortex transport occurs due to the presence of waves between neighboring vortices. The combination of these two mechanisms results in enhanced axial dispersion. We showed that hysteresis may occur between consecutive regimes depending on flow history and this may have a significant effect on mixing for a given Reynolds number. The axial dispersion coefficient Dx evolution along the successive flow states was investigated thanks to dye Residence Time Distribution measurements (RTD) and particle tracking (DNS). Both experimental and numerical results have confirmed the significant effect of the flow structure and history on axial dispersion. Our study confirmed that the commonly used 1-parameter chemical engineering models (e

Adult-onset epilepsy in focal cortical dysplasia of Taylor type

NARCIS (Netherlands)

Siegel, A. M.; Cascino, G. D.; Elger, C. E.; Devinsky, O.; Laff, R.; Najjar, S.; Sperling, M. R.; LoRusso, G.; Cossu, M.; Urbach, H.; Aronica, E.; Meyer, F. B.; Scheithauer, B. W.; Dubeau, F.; Andermann, F.

2005-01-01

Focal cortical dysplasia of Taylor type (FCDT) usually presents with seizures at an early age, whereas adult onset of epilepsy is uncommon. We reviewed the medical records of 213 patients with FCDT. In 21 patients (10%), age at seizure onset ranged from 18 to 55 years (mean 25.3). The outcome of

Rayleigh-Taylor and wind-driven instabilities of the nighttime equatorial ionosphere

International Nuclear Information System (INIS)

Chiu, Y.T.; Straus, J.M.

1979-01-01

We have made a thorough re-examination of the Rayleigh-Taylor instability in the nighttime equatorial ionosphere from approx.100 km to the bottomside F region. We have taken into account explicitly the following effects which have been ignored by other workers in various combinations: (1) The eastward drift of the ionosphere caused by the nighttime polarization electric field, (2) the eastward nighttime neutral wind, and (3) recombination in the F and E regions. We found that, well below the bottomside F region, the Rayleigh-Taylor mode can be unstable and is driven by an eastward neutral wind rather than by gravitational drift. Formation of ionospheric bubbles below the bottomside F region is consistent with the observation of lower ionospheric ions in F region ionospheric holes; furthermore, seasonal and shorter term variations in spread-F occurrence may be associated with variations in the neutral wind and polarization electric field

Identification of Dynamic Loads Based on Second-Order Taylor-Series Expansion Method

Directory of Open Access Journals (Sweden)

Xiaowang Li

2016-01-01

Full Text Available A new method based on the second-order Taylor-series expansion is presented to identify the structural dynamic loads in the time domain. This algorithm expresses the response vectors as Taylor-series approximation and then a series of formulas are deduced. As a result, an explicit discrete equation which associates system response, system characteristic, and input excitation together is set up. In a multi-input-multi-output (MIMO numerical simulation study, sinusoidal excitation and white noise excitation are applied on a cantilever beam, respectively, to illustrate the effectiveness of this algorithm. One also makes a comparison between the new method and conventional state space method. The results show that the proposed method can obtain a more accurate identified force time history whether the responses are polluted by noise or not.

Effect of resistivity on the Rayleigh-Taylor instability in an accelerated plasma

International Nuclear Information System (INIS)

Castillo, J.L.; Huerta, M.A.

1993-01-01

We study the Rayleigh-Taylor instability in finite-conductivity accelerated plasma arcs of the type found in electromagnetic rail launchers. For a plasma of length l, acceleration a, and thermal speed v T we consider the case where v T 2 /al much-gt 1, which is valid when the projectile mass is large compared to the plasma mass. The conductivity σ enters via a magnetic Reynolds number R=σμ(al 3 ) 1/2 . The fourth-order mode equation is solved analytically using an asymptotic WKB expansion in 1/R. We find the first-order 1/R correction to the classical Rayleigh-Taylor dispersion relation for large wave number K but with K much-lt R 2 /l. The analytical results show good agreement with previous numerical calculations

James Taylor (1859-1946): favourite disciple of Hughlings Jackson and William Gowers.

Science.gov (United States)

Eadie, M J

2013-01-01

In neurological circles today the name James Taylor (1859-1946) is probably remembered mainly for his role in editing the Selected Writings of John Hughlings Jackson, the most readily available source of Jackson's contributions to neurological knowledge. Taylors' own neurological achievements are largely or entirely forgotten, but in his day he was an influential figure whose career linked the great figures of the golden era of late nineteenth century British neurology to the neurology of the first half of the twentieth century. Not only was he a junior professional colleague and close friend of both John Hughlings Jackson and William Gowers, he also produced a substantial corpus of neurological writings in his own right, including a textbook of child neurology and the first English language account of subacute combined degeneration of the spinal cord.

The Rayleigh-Taylor instability in a self-gravitating two-layer viscous sphere

Science.gov (United States)

Mondal, Puskar; Korenaga, Jun

2018-03-01

The dispersion relation of the Rayleigh-Taylor instability in the spherical geometry is of profound importance in the context of the Earth's core formation. Here we present a complete derivation of this dispersion relation for a self-gravitating two-layer viscous sphere. Such relation is, however, obtained through the solution of a complex transcendental equation, and it is difficult to gain physical insights directly from the transcendental equation itself. We thus also derive an empirical formula to compute the growth rate, by combining the Monte Carlo sampling of the relevant model parameter space with linear regression. Our analysis indicates that the growth rate of Rayleigh-Taylor instability is most sensitive to the viscosity of inner layer in a physical setting that is most relevant to the core formation.

Hot-pressed geopolymer

DEFF Research Database (Denmark)

Ranjbar, Navid; Mehrali, Mohammad; Maheri, Mahmoud R.

2017-01-01

This research explores the use of simultaneous heating and pressing techniques in order to enhance the mechanical properties of fly ash (FA) based geopolymer under relatively low temperature conditions to ensure minimum-porosity. Four effective parameters of pressing force, alkali activator...

Multiple Hfq-Crc target sites are required to impose catabolite repression on (methyl)phenol metabolism in Pseudomonas putida CF600.

Science.gov (United States)

Wirebrand, Lisa; Madhushani, Anjana W K; Irie, Yasuhiko; Shingler, Victoria

2018-01-01

The dmp-system encoded on the IncP-2 pVI150 plasmid of Pseudomonas putida CF600 confers the ability to assimilate (methyl)phenols. Regulation of the dmp-genes is subject to sophisticated control, which includes global regulatory input to subvert expression of the pathway in the presence of preferred carbon sources. Previously we have shown that in P. putida, translational inhibition exerted by the carbon repression control protein Crc operates hand-in-hand with the RNA chaperon protein Hfq to reduce translation of the DmpR regulator of the Dmp-pathway. Here, we show that Crc and Hfq co-target four additional sites to form riboprotein complexes within the proximity of the translational initiation sites of genes encoding the first two steps of the Dmp-pathway to mediate two-layered control in the face of selection of preferred substrates. Furthermore, we present evidence that Crc plays a hitherto unsuspected role in maintaining the pVI150 plasmid within a bacterial population, which has implications for (methyl)phenol degradation and a wide variety of other physiological processes encoded by the IncP-2 group of Pseudomonas-specific mega-plasmids. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

Measurement of local heat transfer coefficient during gas–liquid Taylor bubble train flow by infra-red thermography

International Nuclear Information System (INIS)

Mehta, Balkrishna; Khandekar, Sameer

2014-01-01

Highlights: • Infra-red thermographic study of Taylor bubble train flow in square mini-channel. • Design of experiments for measurement of local streamwise Nusselt number. • Minimizing conjugate heat transfer effects and resulting errors in data reduction. • Benchmarking against single-phase flow and three-dimensional computations. • Local heat transfer enhancement up to two times due to Taylor bubble train flow. -- Abstract: In mini/micro confined internal flow systems, Taylor bubble train flow takes place within specific range of respective volume flow ratios, wherein the liquid slugs get separated by elongated Taylor bubbles, resulting in an intermittent flow situation. This unique flow characteristic requires understanding of transport phenomena on global, as well as on local spatio-temporal scales. In this context, an experimental design methodology and its validation are presented in this work, with an aim of measuring the local heat transfer coefficient by employing high-resolution InfraRed Thermography. The effect of conjugate heat transfer on the true estimate of local transport coefficients, and subsequent data reduction technique, is discerned. Local heat transfer coefficient for (i) hydrodynamically fully developed and thermally developing single-phase flow in three-side heated channel and, (ii) non-boiling, air–water Taylor bubble train flow is measured and compared in a mini-channel of square cross-section (5 mm × 5 mm; D h = 5 mm, Bo ≈ 3.4) machined on a stainless steel substrate (300 mm × 25 mm × 11 mm). The design of the setup ensures near uniform heat flux condition at the solid–fluid interface; the conjugate effects arising from the axial back conduction in the substrate are thus minimized. For benchmarking, the data from single-phase flow is also compared with three-dimensional computational simulations. Depending on the employed volume flow ratio, it is concluded that enhancement of nearly 1.2–2.0 times in time

Change of Pressing Chamber Conicalness at Briquetting Process in Briquetting Machine Pressing Chamber

Directory of Open Access Journals (Sweden)

Peter Križan

2012-01-01

Full Text Available In this paper, we will present the impact of the conical shape of a pressing chamber, an important structural parameter. Besides the known impact of the technological parameters of pressing chambers, it is also very important to pay attention to their structural parameters. In the introduction, we present a theoretical analysis of pressing chamber conicalness. An experiment aimed at detecting this impact was performed at our institute, and it showed that increasing the conicalness of a pressing chamber improves the quality of the final briquettes. The conicalness of the pressing chamber has a significanteffect on the final briquette quality and on the construction of briquetting machines. The experimental findings presented here show the importance of this parameter in the briquetting process.

Deterministic Role of CEA and MSI Status in Predicting Outcome of CRC Patients: a Perspective Study Amongst Hospital Attending Eastern Indian Populations.

Science.gov (United States)

Koyel, Banerjee; Priyabrata, Das; Rittwika, Bhattacharya; Swati, Dasgupta; Soma, Mukhopadhyay; Jayasri, Basak; Ashis, Mukhopadhyay

2017-12-01

Carcinoembryonic antigen (CEA) is an important deterministic factor in predicting colorectal carcinoma (CRC) progression. It is also evident that microsatellite instability (MSI) which results in a hypermutable phenotype of genomic DNA is common in CRC. Owing to the scarcity of reports from India, our aim of this study was to understand the clinicopathological correlations of CEA status with surgery and chemotherapy, correlate the same with socio-demographic status of the patients, determine the MSI status amongst them and understand the prognostic implications of CEA and MSI as CRC progression marker amongst patients. The serum CEA level was estimated by chemiluminescence assay (CLIA). Serum liver enzyme assay was carried out following the manufacturer's instructions using auto-analysers (E. Merck and Sera mol. Health Care, India). MSI analysis was carried out by PCR-SSCP. From our study, most frequently detected colorectal cancer was in 40-49 years age group (25.26%) with 61.05% male and 38.95% females. CEA showed a significant association with higher TNM staging, tumour size, smoking habit and MSI status ( p   0.05). After surgery and chemotherapy, CEA and WBCs were decreased significantly ( p   0.05). Overall, microsatellite instability was observed in approximately 40% of the populations. From our study, it was also evident that for both, MSI and abnormal CEA level predicted poor prognosis for the patient (by using Kaplan-Meier survival analysis; p  = 0.04). Thus, CEA and initial MSI status can be used as prognostic markers of CRC.

The mitigation effect of sheared axial flow on the rayleigh-taylor instability in Z-pinch plasma

International Nuclear Information System (INIS)

Zhang Yang

2005-01-01

A magnetohydrodynamic formulation is derived to investigate the mitigation effects of the sheared axial flow on the Rayleigh-Taylor (RT) instability in Z-pinch plasma. The dispersion relation of the compressible model is given. The mitigation effects of sheared axial flow on the Rayleigh-Taylor instability of Z-pinch plasma in the compressible and incompressible models are compared respectively, and the effect of compressible on the instability of system with sheared axial flow is discussed. It is found that, compressibility effects can stabilize the Rayleigh-Taylor/Kelvin-Helmholtz (RT/KH) instability, and this allows the sheared axial flow mitigate the RT instability far more effectively. The authors also find that, at the early stage of the implosion, if the temperature of the plasma is not very high, the compressible model is much more suitable to describing the state of system than the incompressible one. (author)

Teach yourself visually WordPress

CERN Document Server

Majure, Janet

2012-01-01

Get your blog up and running with the latest version of WordPress WordPress is one of the most popular, easy-to-use blogging platforms and allows you to create a dynamic and engaging blog, even if you have no programming skills or experience. Ideal for the visual learner, Teach Yourself VISUALLY WordPress, Second Edition introduces you to the exciting possibilities of the newest version of WordPress and helps you get started, step by step, with creating and setting up a WordPress site. Author and experienced WordPress user Janet Majure shares advice, insight, and best practices for taking full

Inertial migration of particles in Taylor-Couette flows

Science.gov (United States)

Majji, Madhu V.; Morris, Jeffrey F.

2018-03-01

An experimental study of inertial migration of neutrally buoyant particles in the circular Couette flow (CCF), Taylor vortex flow (TVF) and wavy vortex flow (WVF) is reported. This work considers a concentric cylinder Taylor-Couette device with a stationary outer cylinder and rotating inner cylinder. The device has a radius ratio of η = ri/ro = 0.877, where ri and ro are the inner and outer radii of the flow annulus. The ratio of the annular width between the cylinders (δ = ro - ri) and the particle diameter (dp) is α = δ/dp = 20. For η = 0.877, the flow of a Newtonian fluid undergoes transitions from CCF to TVF and TVF to WVF at Reynolds numbers Re = 120 and 151, respectively, and for the dilute suspensions studied here, these critical Reynolds numbers are almost unchanged. In CCF, particles were observed to migrate, due to the competition between the shear gradient of the flow and the wall interactions, to an equilibrium location near the middle of the annulus with an offset toward the inner cylinder. In TVF, the vortex motion causes the particles to be exposed to the shear gradient and wall interactions in a different manner, resulting in a circular equilibrium region in each vortex. The radius of this circular region grows with increase in Re. In WVF, the azimuthal waviness results in fairly well-distributed particles across the annulus.

Bifurcating fronts for the Taylor-Couette problem in infinite cylinders

Science.gov (United States)

Hărăguş-Courcelle, M.; Schneider, G.

We show the existence of bifurcating fronts for the weakly unstable Taylor-Couette problem in an infinite cylinder. These fronts connect a stationary bifurcating pattern, here the Taylor vortices, with the trivial ground state, here the Couette flow. In order to show the existence result we improve a method which was already used in establishing the existence of bifurcating fronts for the Swift-Hohenberg equation by Collet and Eckmann, 1986, and by Eckmann and Wayne, 1991. The existence proof is based on spatial dynamics and center manifold theory. One of the difficulties in applying center manifold theory comes from an infinite number of eigenvalues on the imaginary axis for vanishing bifurcation parameter. But nevertheless, a finite dimensional reduction is possible, since the eigenvalues leave the imaginary axis with different velocities, if the bifurcation parameter is increased. In contrast to previous work we have to use normalform methods and a non-standard cut-off function to obtain a center manifold which is large enough to contain the bifurcating fronts.

Self Reported Awareness of Child Maltreatment among School Professionals in Saudi Arabia: Impact of CRC Ratification

Science.gov (United States)

AlBuhairan, Fadia S.; Inam, Sarah S.; AlEissa, Majid A.; Noor, Ismail K.; Almuneef, Maha A.

2011-01-01

Objectives: The Convention on the Rights of the Child (CRC) was ratified by Saudi Arabia 15 years ago; yet addressing the issue of child maltreatment only began in more recent years. School professionals play a significant role in children's lives, as they spend a great deal of time with them and are hence essential to protecting and identifying…

Bias Correction with Jackknife, Bootstrap, and Taylor Series

OpenAIRE

Jiao, Jiantao; Han, Yanjun; Weissman, Tsachy

2017-01-01

We analyze the bias correction methods using jackknife, bootstrap, and Taylor series. We focus on the binomial model, and consider the problem of bias correction for estimating $f(p)$, where $f \\in C[0,1]$ is arbitrary. We characterize the supremum norm of the bias of general jackknife and bootstrap estimators for any continuous functions, and demonstrate the in delete-$d$ jackknife, different values of $d$ may lead to drastically different behavior in jackknife. We show that in the binomial ...

Slavnov-Taylor1.0: A Mathematica package for computation in BRST formalism

CERN Document Server

Picariello, Marco; Picariello, Marco; Torrente-Lujan, Emilio

2004-01-01

Slavnov-Taylor1.0 is a Mathematica package which allows us to perform automatic simbolic computation in BRST formalism. This article serves as a self-contained guide to prospective users, and indicates the conventions and approximations used.

On Taylor-Series Approximations of Residual Stress

Science.gov (United States)

Pruett, C. David

1999-01-01

Although subgrid-scale models of similarity type are insufficiently dissipative for practical applications to large-eddy simulation, in recently published a priori analyses, they perform remarkably well in the sense of correlating highly against exact residual stresses. Here, Taylor-series expansions of residual stress are exploited to explain the observed behavior and "success" of similarity models. Until very recently, little attention has been given to issues related to the convergence of such expansions. Here, we re-express the convergence criterion of Vasilyev [J. Comput. Phys., 146 (1998)] in terms of the transfer function and the wavenumber cutoff of the grid filter.

Nonlinear saturation of the Rayleigh Taylor instability

International Nuclear Information System (INIS)

Das, A.; Mahajan, S.; Kaw, P.; Sen, A.; Benkadda, S.; Verga, A.

1997-01-01

The problem of the nonlinear saturation of the 2 dimensional Rayleigh Taylor instability is re-examined to put various earlier results in a proper perspective. The existence of a variety of final states can be attributed to the differences in the choice of boundary conditions and initial conditions in earlier numerical modeling studies. Our own numerical simulations indicate that the RT instability saturates by the self consistent generation of shear flow even in situations (with periodic boundaries) where, in principle, an infinite amount of gravitational energy can be tapped. Such final states can be achieved for suitable values of the Prandtl number. (author)

Analysis of Institutional Press Releases and its Visibility in the Press

Directory of Open Access Journals (Sweden)

José Antonio Alcoceba-Hernando, Ph.D.

2010-01-01

Full Text Available The relationships between institutional communication and media communication influence the shaping of social representations of public issues. This research article analyses these relationships based on the case study of the external communication of a public institution, the press releases of Spain’s Youth Institute (Instituto de la Juventud, aka, Injuve, during three years and their repercussion in the press during the same period of time. The results obtained in this research allowed drawing conclusions on the types of communication production of the aforementioned institution and the news treatment of such pieces of information by the printed and digital media. The press releases and the news items were studied using quantitative media content analysis which focused, especially, in referential issues like the information treatment, the thematic analysis, youth representations in the case of the releases; and the visibility of the press releases in the making of news

Method of generalized coordinates and an application to Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Dienes, J.K.

1978-01-01

The method of generalized coordinates is extended to the analysis of continuous bodies for which the degrees of freedom are independent velocity distributions in the spatial coordinates. The corresponding Lagrange equations contain generalized convective terms as well as the usual generalized forces and masses. Since the existence of a potential is not assumed, the equations of motion can be applied to media with arbitrary (possible dissipative) constitutive laws. Material deformation is characterized by the rate of strain, which is taken as the symmetric part of the velocity gradient, making the approach valid for arbitrarily large deformations. As an example, infinitesimal Rayleigh-Taylor instability is considered by analytic methods. Then, large amplitude Rayleigh-Taylor instability is represented with a single-degree-of-freedom analysis that shows the development (by numerical integration) of the known spike-and-bubble configuration of the unstable interface. The infinitesimal stability of a plastically deforming solid and the growth of the instability to large amplitudes are also considered

Solution of the agglomerate Brownian coagulation using Taylor-expansion moment method.

Science.gov (United States)

Yu, Mingzhou; Lin, Jianzhong

2009-08-01

The newly proposed Taylor-expansion moment method (TEMOM) is extended to solve agglomerate coagulation in the free-molecule regime and in the continuum regime, respectively. The moment equations with respect to fractal dimension are derived based on 3rd Taylor-series expansion technique. The validation of this method is done by comparing its result with the published data at each limited size regime. By comparing with analytical method, sectional method (SM) and quadrature method of moments (QMOMs), this new approach is shown to produce the most efficiency without losing much accuracy. At each limited size regime, the effect of fractal dimension on the decay of particle number and particle size growth is mainly investigated, and especially in the continuum regime the relation of mean diameters of size distributions with different fractal dimensions is first proposed. The agglomerate size distribution is found to be sensitive to the fractal dimension and the initial geometric mean deviation before the self-preserving size distribution is achieved in the continuum regime.

Taylor's Theorem: The Elusive "c" Is Not So Elusive

Science.gov (United States)

Kreminski, Richard

2010-01-01

For a suitably nice, real-valued function "f" defined on an open interval containing [a,b], f(b) can be expressed as p[subscript n](b) (the nth Taylor polynomial of f centered at a) plus an error term of the (Lagrange) form f[superscript (n+1)](c)(b-a)[superscript (n+1)]/(n+1)! for some c in (a,b). This article is for those who think that not…

Interpreted Modernity. Weber and Taylor on Values and Modernity

OpenAIRE

Reckling, Falk

2001-01-01

The writings of Weber and Taylor have some strong affinities. Both start from the anthropological idea that man evaluates his position in the world and constitutes the social world by values. Their analyses of values aim at an understanding of those intersubjective meanings that have constituted western modernity. But, at the same time, their anthropological starting point leads to different interpretations of modernity. Historically, both argue that rationalization (as instrumental rationali...

Effect of gas expansion on the front shape of a Taylor bubble: an experimental contribution

Directory of Open Access Journals (Sweden)

Santos Laura

2014-03-01

Full Text Available An experimental study where an individual Taylor bubble rises through water with different bubble volume expansion rates is presented with the (front bubble shape determination as main objective. A combination of two techniques, Particle Image Velocimetry (PIV and Pulsed Shadowgraphy (PS, was used to collect images for further treatment in order to characterize the liquid flow pattern in front of the bubble and the bubble shape. Processing the images acquired with pulsed illumination from behind the bubble it was possible to define with precision the bubble shape at different stages when it was expanding. The operation conditions used allowed a wide range of volume expansion rates (0 to 28.5 × 10-6 m3/s with a significant effect on the Taylor bubble velocity; increases in bubble velocity up to 21% were observed relatively to constant volume system condition. Nevertheless, it seems that the front shape of Taylor bubbles does not change significantly with the upward liquid flow rates induced by gas expansion, at least for the volume expansion rates used in the experiments.

CRC DEPLETION CALCULATIONS FOR THE RODDED ASSEMBLIES IN BATCHES 1, 2, 3, AND 1X OF CRYSTAL RIVER UNIT 3

Energy Technology Data Exchange (ETDEWEB)

Kenneth D. Wright

1997-09-03

The purpose of this design analysis is to document the SAS2H depletion calculations of certain rodded fuel assemblies from batches 1, 2, 3, and 1X of the Crystal River Unit 3 pressurized water reactor (PWR) that are required for Commercial Reactor Critical (CRC) evaluations to support the development of the disposal criticality methodology. A rodded assembly is one that contains a control rod assembly (CRA) or an axial power shaping rod assembly (APSRA) for some period of time during its irradiation history. The objective of this analysis is to provide SAS2H calculated isotopic compositions of depleted fuel and depleted burnable poison for each fuel assembly to be used in subsequent CRC reactivity calculations containing the fuel assemblies.

CRC DEPLETION CALCULATIONS FOR THE RODDED ASSEMBLIES IN BATCHES 1, 2, 3, AND 1X OF CRYSTAL RIVER UNIT 3

International Nuclear Information System (INIS)

Wright, Kenneth D.

1997-01-01

The purpose of this design analysis is to document the SAS2H depletion calculations of certain rodded fuel assemblies from batches 1, 2, 3, and 1X of the Crystal River Unit 3 pressurized water reactor (PWR) that are required for Commercial Reactor Critical (CRC) evaluations to support the development of the disposal criticality methodology. A rodded assembly is one that contains a control rod assembly (CRA) or an axial power shaping rod assembly (APSRA) for some period of time during its irradiation history. The objective of this analysis is to provide SAS2H calculated isotopic compositions of depleted fuel and depleted burnable poison for each fuel assembly to be used in subsequent CRC reactivity calculations containing the fuel assemblies

Designs for highly nonlinear ablative Rayleigh-Taylor experiments on the National Ignition Facility

International Nuclear Information System (INIS)

Casner, A.; Masse, L.; Liberatore, S.; Jacquet, L.; Loiseau, P.; Poujade, O.; Smalyuk, V. A.; Bradley, D. K.; Park, H. S.; Remington, B. A.; Igumenshchev, I.; Chicanne, C.

2012-01-01

We present two designs relevant to ablative Rayleigh-Taylor instability in transition from weakly nonlinear to highly nonlinear regimes at the National Ignition Facility [E. I. Moses, J. Phys.: Conf. Ser. 112, 012003 (2008)]. The sensitivity of nonlinear Rayleigh-Taylor instability physics to ablation velocity is addressed with targets driven by indirect drive, with stronger ablative stabilization, and by direct drive, with weaker ablative stabilization. The indirect drive design demonstrates the potential to reach a two-dimensional bubble-merger regime with a 20 ns duration drive at moderate radiation temperature. The direct drive design achieves a 3 to 5 times increased acceleration distance for the sample in comparison to previous experiments allowing at least 2 more bubble generations when starting from a three-dimensional broadband spectrum.

Designs for highly nonlinear ablative Rayleigh-Taylor experiments on the National Ignition Facility

Energy Technology Data Exchange (ETDEWEB)

Casner, A.; Masse, L.; Liberatore, S.; Jacquet, L.; Loiseau, P.; Poujade, O. [CEA, DAM, DIF, F-91297 Arpajon (France); Smalyuk, V. A.; Bradley, D. K.; Park, H. S.; Remington, B. A. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Igumenshchev, I. [Laboratory of Laser Energetics, University of Rochester, Rochester, New York 14623-1299 (United States); Chicanne, C. [CEA, DAM, VALDUC, F-21120 Is-sur-Tille (France)

2012-08-15

We present two designs relevant to ablative Rayleigh-Taylor instability in transition from weakly nonlinear to highly nonlinear regimes at the National Ignition Facility [E. I. Moses, J. Phys.: Conf. Ser. 112, 012003 (2008)]. The sensitivity of nonlinear Rayleigh-Taylor instability physics to ablation velocity is addressed with targets driven by indirect drive, with stronger ablative stabilization, and by direct drive, with weaker ablative stabilization. The indirect drive design demonstrates the potential to reach a two-dimensional bubble-merger regime with a 20 ns duration drive at moderate radiation temperature. The direct drive design achieves a 3 to 5 times increased acceleration distance for the sample in comparison to previous experiments allowing at least 2 more bubble generations when starting from a three-dimensional broadband spectrum.

An integral equation-based numerical solver for Taylor states in toroidal geometries

Science.gov (United States)

O'Neil, Michael; Cerfon, Antoine J.

2018-04-01

We present an algorithm for the numerical calculation of Taylor states in toroidal and toroidal-shell geometries using an analytical framework developed for the solution to the time-harmonic Maxwell equations. Taylor states are a special case of what are known as Beltrami fields, or linear force-free fields. The scheme of this work relies on the generalized Debye source representation of Maxwell fields and an integral representation of Beltrami fields which immediately yields a well-conditioned second-kind integral equation. This integral equation has a unique solution whenever the Beltrami parameter λ is not a member of a discrete, countable set of resonances which physically correspond to spontaneous symmetry breaking. Several numerical examples relevant to magnetohydrodynamic equilibria calculations are provided. Lastly, our approach easily generalizes to arbitrary geometries, both bounded and unbounded, and of varying genus.

WordPress Top Plugins

CERN Document Server

Corbin, Brandon

2010-01-01

Time flies when you're having fun. This is the right way to describe this WordPress Top Plugins book by Brandon Corbin. With real world examples and by showing you the perks of having these plugins installed on your websites, the author is all set to captivate your interest from start to end. Regardless of whether this is your first time working with WordPress, or you're a seasoned WordPress coding ninja, WordPress Top Plugins will walk you through finding and installing the best plugins for generating and sharing content, building communities and reader base, and generating real advertising r

Self-similarity in high Atwood number Rayleigh-Taylor experiments

Science.gov (United States)

Mikhaeil, Mark; Suchandra, Prasoon; Pathikonda, Gokul; Ranjan, Devesh

2017-11-01

Self-similarity is a critical concept in turbulent and mixing flows. In the Rayleigh-Taylor instability, theory and simulations have shown that the flow exhibits properties of self-similarity as the mixing Reynolds number exceeds 20000 and the flow enters the turbulent regime. Here, we present results from the first large Atwood number (0.7) Rayleigh-Taylor experimental campaign for mixing Reynolds number beyond 20000 in an effort to characterize the self-similar nature of the instability. Experiments are performed in a statistically steady gas tunnel facility, allowing for the evaluation of turbulence statistics. A visualization diagnostic is used to study the evolution of the mixing width as the instability grows. This allows for computation of the instability growth rate. For the first time in such a facility, stereoscopic particle image velocimetry is used to resolve three-component velocity information in a plane. Velocity means, fluctuations, and correlations are considered as well as their appropriate scaling. Probability density functions of velocity fields, energy spectra, and higher-order statistics are also presented. The energy budget of the flow is described, including the ratio of the kinetic energy to the released potential energy. This work was supported by the DOE-NNSA SSAA Grant DE-NA0002922.

Taylor-series method for four-nucleon wave functions

International Nuclear Information System (INIS)

Sandulescu, A.; Tarnoveanu, I.; Rizea, M.

1977-09-01

Taylor-series method for transforming the infinite or finite well two-nucleon wave functions from individual coordinates to relative and c.m. coordinates, by expanding the single particle shell model wave functions around c.m. of the system, is generalized to four-nucleon wave functions. Also the connections with the Talmi-Moshinsky method for two and four harmonic oscillator wave functions are deduced. For both methods Fortran IV programs for the expansion coefficients have been written and the equivalence of corresponding expressions numerically proved. (author)

Which Freedom of the Press?

DEFF Research Database (Denmark)

Rytter, Jens Elo

2010-01-01

The article surveys the historical and current meaning of "Freedom of the Press" in constitutional and human rights law. Two different conceptions exist, the narrow one defining freedom of the press as the freedom of every one to publish without prior restraint, the broader one defining it as a...... privileged freedom of the organised press to gather and report on information of public interest. These two conceptions have very different answers to the question of whether the press should enjoy some privilege to be exempt from ordinary legislation when such legislation restricts the access of the press to inform...

Resurrecting Democracies : Secularity Recast in Charles Taylor, Paul Valadier, and Joseph Ratzinger

NARCIS (Netherlands)

Ossewaarde-Lowtoo, Roshnee

In this article, the alternative conception of secularity of Charles Taylor, Paul Valadier and Joseph Ratzinger (former Benedict XVI) is explored. A secularized society, which they take as an established condition, does not necessarily exclude religion, Christianity or Christian transcendence, in

Taylor-plasticity-based analysis of length scale effects in void growth

KAUST Repository

Liu, Junxian

2014-09-25

We have studied the void growth problem by employing the Taylor-based strain gradient plasticity theories, from which we have chosen the following three, namely, the mechanism-based strain gradient (MSG) plasticity (Gao et al 1999 J. Mech. Phys. Solids 47 1239, Huang et al 2000 J. Mech. Phys. Solids 48 99-128), the Taylor-based nonlocal theory (TNT; 2001 Gao and Huang 2001 Int. J. Solids Struct. 38 2615) and the conventional theory of MSG (CMSG; Huang et al 2004 Int. J. Plast. 20 753). We have addressed the following three issues which occur when plastic deformation at the void surface is unconstrained. (1) Effects of elastic deformation. Elasticity is essential for cavitation instability. It is therefore important to guarantee that the gradient term entering the Taylor model is the effective plastic strain gradient instead of the total strain gradient. We propose a simple elastic-plastic decomposition method. When the void size approaches the minimum allowable initial void size related to the maximum allowable geometrically necessary dislocation density, overestimation of the flow stress due to the negligence of the elastic strain gradient is on the order of lεY/R0 near the void surface, where l, εY and R0 are, respectively, the intrinsic material length scale, the yield strain and the initial void radius. (2) MSG intrinsic inconsistency, which was initially mentioned in Gao et al (1999 J. Mech. Phys. Solids 47 1239) but has not been the topic of follow-up studies. We realize that MSG higher-order stress arises due to the linear-strain-field approximation within the mesoscale cell with a nonzero size, lε. Simple analysis shows that within an MSG mesoscale cell near the void surface, the difference between microscale and mesoscale strains is on the order of (lε/R0)2, indicating that when lε/R0 ∼ 1.0, the higher-order stress effect can make the MSG result considerably different from the TNT or CMSG results. (3) Critical condition for cavitation instability

Theoretical and numerical study of Rayleigh-Taylor instabilities in magnetized plasmas

International Nuclear Information System (INIS)

Andrei, A. Ivanov

2001-06-01

In this thesis we're studying both the general case of the 'classic' Rayleigh-Taylor instability (in incompressible fluids) and more specific cases of the instabilities of Rayleigh-Taylor type in magnetized plasmas, in the liners or wire array implosions etc. We have studied the influence of the Hall diffusion of magnetic field on the growth rate of the instability. We have obtained in this work a self-similar solution for the widening of the initial profile of the magnetic field and for the wave of the penetration of magnetic field. After that the subsequent evolution of the magnetic field in plasma opening switches (POS) has been examined. We have shown the possibility of the existence of a strong rarefaction wave for collisional and non-collisional cases. This wave can explain the phenomenon of the opening of POS. The effect of the suppression of Rayleigh-Taylor instability by forced oscillations of the boundary between two fluids permits us to propose some ideas for the experiments of inertial fusion. We have considered the general case of the instability, in other words - two incompressible viscous superposed fluids in a gravitational field. We have obtained an exact analytical expression for the growth rate and then we have analyzed the influence of the parameters of external 'pumping' on the instability. These results can be applied to a wide range of systems, starting from classic hydrodynamics and up to astrophysical plasmas. The scheme of wire arrays has become recently a very popular method to obtain a high power X-radiation or for a high quality implosion in Z-pinches. The experimental studies have demonstrated that the results of implosion are much better for the case of multiple thin wires situated cylindrically than in a usual liner scheme. We have examined the problem modeling the stabilization of Rayleigh-Taylor instability for a wire array system. The reason for instability suppression is the regular spatial modulation of the surface plasma

High-Speed Solution of Spacecraft Trajectory Problems Using Taylor Series Integration

Science.gov (United States)

Scott, James R.; Martini, Michael C.

2010-01-01

It has been known for some time that Taylor series (TS) integration is among the most efficient and accurate numerical methods in solving differential equations. However, the full benefit of the method has yet to be realized in calculating spacecraft trajectories, for two main reasons. First, most applications of Taylor series to trajectory propagation have focused on relatively simple problems of orbital motion or on specific problems and have not provided general applicability. Second, applications that have been more general have required use of a preprocessor, which inevitably imposes constraints on computational efficiency. The latter approach includes the work of Berryman et al., who solved the planetary n-body problem with relativistic effects. Their work specifically noted the computational inefficiencies arising from use of a preprocessor and pointed out the potential benefit of manually coding derivative routines. In this Engineering Note, we report on a systematic effort to directly implement Taylor series integration in an operational trajectory propagation code: the Spacecraft N-Body Analysis Program (SNAP). The present Taylor series implementation is unique in that it applies to spacecraft virtually anywhere in the solar system and can be used interchangeably with another integration method. SNAP is a high-fidelity trajectory propagator that includes force models for central body gravitation with N X N harmonics, other body gravitation with N X N harmonics, solar radiation pressure, atmospheric drag (for Earth orbits), and spacecraft thrusting (including shadowing). The governing equations are solved using an eighth-order Runge-Kutta Fehlberg (RKF) single-step method with variable step size control. In the present effort, TS is implemented by way of highly integrated subroutines that can be used interchangeably with RKF. This makes it possible to turn TS on or off during various phases of a mission. Current TS force models include central body

Charles Taylor na Haia: limites da justiça internacional?

Directory of Open Access Journals (Sweden)

IZADORA XAVIER DO MONTE

2010-11-01

Full Text Available Recentemente o julgamento de Charles Taylor, um dos protagonistas no conflito civil na Libéria, atraiu a corte internacional em Haia para o foco da comunidade internacional. Assim, o presente artigo busca delimitar as conseqüências políticas e jurídicas que advirão desse processo para a comunidade internacional como um todo.

Hot-pressing steatite bodies

International Nuclear Information System (INIS)

Aparicio Arroyo, E.

1967-01-01

Requirements for some special nuclear engineering ceramic shapes are: big size, impervious, dimensional accuracy and good mechanical and dielectric properties. Limitations of te conventional methods and advantages of te hot pressing techniques for the manufacturing of these shapes are discussed. Hot pressing characteristics of a certain steatite powder are studied. Occurrence of an optimum densification temperature just above the tale decomposition range is found. Experimental data show that the height/diameter ratio of the specimen has no effect on the sintering conditions. Increasing darkness from the graphite mould is detected above the optimum temperature. The hot-pressed steatite is compared with a fired dry-pressed sample of the same composition. (Author) 13 refs

Mathematical modelling of wet paper pressing

NARCIS (Netherlands)

Bežanovic, D.

2005-01-01

The aim of this project is to reduce energy costs in paper production by optimising the process in the press section of a paper machine. In this press section water is squeezed as it passes through the press nip. In a modern press section the moisture content of the sheet after three or four presses

A Study of Heat Transfer and Flow Characteristics of Rising Taylor Bubbles

Science.gov (United States)

Scammell, Alexander David

2016-01-01

Practical application of flow boiling to ground- and space-based thermal management systems hinges on the ability to predict the systems heat removal capabilities under expected operating conditions. Research in this field has shown that the heat transfer coefficient within two-phase heat exchangers can be largely dependent on the experienced flow regime. This finding has inspired an effort to develop mechanistic heat transfer models for each flow pattern which are likely to outperform traditional empirical correlations. As a contribution to the effort, this work aimed to identify the heat transfer mechanisms for the slug flow regime through analysis of individual Taylor bubbles.An experimental apparatus was developed to inject single vapor Taylor bubbles into co-currently flowing liquid HFE 7100. The heat transfer was measured as the bubble rose through a 6 mm inner diameter heated tube using an infrared thermography technique. High-speed flow visualization was obtained and the bubble film thickness measured in an adiabatic section. Experiments were conducted at various liquid mass fluxes (43-200 kgm2s) and gravity levels (0.01g-1.8g) to characterize the effect of bubble drift velocityon the heat transfer mechanisms. Variable gravity testing was conducted during a NASA parabolic flight campaign.Results from the experiments showed that the drift velocity strongly affects the hydrodynamics and heat transfer of single elongated bubbles. At low gravity levels, bubbles exhibited shapes characteristic of capillary flows and the heat transfer enhancement due to the bubble was dominated by conduction through the thin film. At moderate to high gravity, traditional Taylor bubbles provided small values of enhancement within the film, but large peaks in the wake heat transfer occurred due to turbulent vortices induced by the film plunging into the trailing liquid slug. Characteristics of the wake heat transfer profiles were analyzed and related to the predicted velocity field

MiniDraw

DEFF Research Database (Denmark)

2018-01-01

MiniDraw is a teaching-oriented 2D graphics direct manipulation framework in Java, inspired by JHotDraw. It is used in the book "Flexible, Reliable Software - using Patterns and Agile Development", by Henrik Bærbak Christensen, published by CRC Press 2010.......MiniDraw is a teaching-oriented 2D graphics direct manipulation framework in Java, inspired by JHotDraw. It is used in the book "Flexible, Reliable Software - using Patterns and Agile Development", by Henrik Bærbak Christensen, published by CRC Press 2010....

Numerical analyses of a Couette-Taylor flow in the presence of a magnetic field

International Nuclear Information System (INIS)

Tagawa, T; Kaneda, M

2005-01-01

An axisymmetric Couette-Taylor flow of liquid metal in the presence of a magnetic field has been numerically studied. An inner cylinder of a coaxial container is rotating at a constant angular velocity whereas the outer cylindrical wall is at rest. An axial or a toroidal magnetic field is applied to this configuration to investigate the influence of such magnetic fields on the liquid metal Couette-Taylor flow. The toroidal magnetic field can be produced with a straight wire along the central axis in which electric current passes. The governing equations of mass conservation, momentum, Ohm's law and conservation of electric charge for an axisymmetric cylindrical coordinate system have been numerically solved with a finite difference method using the HSMAC algorithm. In the numerical analyses, since the Joule heating and the induced magnetic field are neglected, the system parameters are the Hartmann number and the Reynolds number. The numerical results reveal significant difference in the Couette-Taylor flow depending on whether the applied magnetic field is axial or toroidal as well as on the Hartmann and Reynolds numbers. The axial magnetic field damps out the secondary flow efficiently and velocity gradient in the direction of the magnetic field tends to diminish while the toroidal magnetic field does not have such an efficient damping

Rayleigh-Taylor instability in accelerated elastic-solid slabs

Science.gov (United States)

Piriz, S. A.; Piriz, A. R.; Tahir, N. A.

2017-12-01

We develop the linear theory for the asymptotic growth of the incompressible Rayleigh-Taylor instability of an accelerated solid slab of density ρ2, shear modulus G , and thickness h , placed over a semi-infinite ideal fluid of density ρ110.1007/s000330050121] to arbitrary values of AT and unveil the singular feature of an instability threshold below which the slab is stable for any perturbation wavelength. As a consequence, an accelerated elastic-solid slab is stable if ρ2g h /G ≤2 (1 -AT) /AT .

The Psychological Concepts in Taylor Swift's "Blank Space"

OpenAIRE

Anindhita, Novia Putri

2016-01-01

“Blank Space” is a song that is sung by a singer, Taylor Swift. The lyrics tell about the lonely woman who dates a lot but always fails to manage her relationship. However, it does not make her worry to start a new relationship. The purpose of this study is to analyze the elements of the poetry in the lyrics and to show the readers the psychological contents as portrayed in the music video. The study uses intrinsic and extrinsic theories to analyze the data and library research to compile the...

Analysis of weakly nonlinear three-dimensional Rayleigh--Taylor instability growth

International Nuclear Information System (INIS)

Dunning, M.J.; Haan, S.W.

1995-01-01

Understanding the Rayleigh--Taylor instability, which develops at an interface where a low density fluid pushes and accelerates a higher density fluid, is important to the design, analysis, and ultimate performance of inertial confinement fusion targets. Existing experimental results measuring the growth of two-dimensional (2-D) perturbations (perturbations translationally invariant in one transverse direction) are adequately modeled using the 2-D hydrodynamic code LASNEX [G. B. Zimmerman and W. L. Kruer, Comments Plasma Phys. Controlled Fusion 11, 51 (1975)]. However, of ultimate interest is the growth of three-dimensional (3-D) perturbations such as those initiated by surface imperfections or illumination nonuniformities. Direct simulation of such 3-D experiments with all the significant physical processes included and with sufficient resolution is very difficult. This paper addresses how such experiments might be modeled. A model is considered that couples 2-D linear regime hydrodynamic code results with an analytic model to allow modeling of 3-D Rayleigh--Taylor growth through the linear regime and into the weakly nonlinear regime. The model is evaluated in 2-D by comparison with LASNEX results. Finally the model is applied to estimate the dynamics of a hypothetical 3-D foil

Changing Course: Thurgood Marshall College Fund President Johnny Taylor Seeks New Partnerships and Avenues of Support for Public HBCUs

Science.gov (United States)

Stuart, Reginald

2011-01-01

When veteran educator Dr. N. Joyce Payne handed the reins of the organization she founded, the Thurgood Marshall College Fund, to entertainment lawyer and board member Johnny Taylor, Taylor began pursuing a remake of the prestigious group that has turned it on its head in just a matter of months. Today, with just more than a year of leading the…

Cyclic and seasonal features in the behaviour of linear growth increment of Rayleigh-Taylor instability in equatorial F-region

International Nuclear Information System (INIS)

Farkullin, M.N.; Nikitin, M.A.; Kashchenko, N.M.

1989-01-01

Calculations of linear increment of the Rayleigh-Taylor instability for various geophysical conditions are presented. It is shwn that space-time characteristics of increment depend strongly on conditions of solar activity and seasons. The calculation results are in a good agreement with statistical regularities of F-scattering observation in equatorial F-area, which points to the Rayleigh-Taylor natur of the penomena

Book review: Biology and management of invasive quagga and zebra mussels in the western United States

Science.gov (United States)

Benson, Amy J.

2017-01-01

Water is a precious and limited commodity in the western United States and its conveyance is extremely important. Therefore, it is critical to do as much as possible to prevent the spread of two species of dreissenid mussels, both non-native and highly invasive aquatic species already well-established in the eastern half of the United States. This book addresses the occurrences of the two dreissenid mussels in the West, the quagga mussel and the zebra mussel, that are both known to negatively impact water delivery systems and natural ecosystems. It is edited by two researchers whom have extensive experience working with the mussels in the West and is composed of 34 chapters, or articles, written by a variety of experts.Book information: Biology and Management of Invasive Quagga and Zebra Mussels in the Western United States. Edited by Wai Hing Wong and Shawn L. Gerstenberger. Boca Raton (Florida): CRC Press (Taylor & Francis Group). $149.95. xx + 545 p.; ill.; index. ISBN: 978-1-4665-9561-3. [Compact Disc included.] 2015.

77 FR 15609 - Revocation of TSCA Section 4 Testing Requirements for Certain High Production Volume Chemical...

Science.gov (United States)

2012-03-16

... substitute language for your requested changes. iv. Describe any assumptions and provide any technical... boiling point listed for that chemical substance in the ``Handbook of Chemistry and Physics'' (Ref. 21...-0182). 21. CRC Handbook of Chemistry and Physics. 85th Edition. David R. Lide, ed., CRC Press. Boca...

Growth of Rayleigh-Taylor and bulk convective instabilities in dynamics of plasma liners and pinches

International Nuclear Information System (INIS)

Bud'ko, A.B.; Velikovich, A.L.; Liberman, M.A.; Felber, F.S.

1989-01-01

Perturbation growth is studied for the initial, linear stage of an instability development in the course of a cylindrically-symmetric compression and expansion of plasma liners and Z-pinches with a sharp boundary. The hydrodynamic instabilities are Rayleigh-Taylor and bulk convective ones, the former being the most dengerous. Classification of the instability modes developing in accelerated plasmas, inclusing the local and global Rayleigh-Taylor modes, is given. The spectra of the instability growth rates are calculated for plasma liners and Z-pinches. The properties of the spectra appear to explain the filamentation and stratification of plasmas observed in the experiments with liners and Z-pinches. An axial magnetic field is shown to create a window of stability in the space of the flow parameters, where th Rayleigh-Taylor modes are fully suppressed by the magnetic shear, and the bulk convective ones - to a considerable extent. The axial magnetic field required to stabilize the implosion of a liner is estimated as B z0 =(10-30 kG)I(MA)/R 0 (cm), where I is the average current, R 0 - the initial radius of the liner

The Taylor relation in compression deformed Ge single crystals

International Nuclear Information System (INIS)

Nyilas, K; Ungar, T; Dupas, C; Martin, J L; Kruml, T

2010-01-01

Ge single crystals are deformed in compression at 850K and the same strain rate to various extents of strains. In each sample, the internal stress is measured through stress reduction tests and the dislocation densities by X-ray measurements. Data about these two parameters follow fairly well the Taylor-Saada relation, provided a correction term is added. It probably corresponds to dislocations which are seen by X-rays, though they do not contribute to crystal hardening.

An experimental study of the connection between the hydrodynamic and phase-transition descriptions of the Couette-Taylor instability

International Nuclear Information System (INIS)

Berland, T.; Joessang, T.; Feder, J.

1986-04-01

The laser doppler velocimetry technique has been used to measure the radial flow velocity in the Taylor vortex flow at several Taylor numbers close to and above the critical value. The first four harmonics of the flow field have been analyzed using a model described by Davey. The analysis demonstrates that the amplitude of the first harmonic of the super-critical flow field can be regarded as the ''order parameter'' of the transition from the laminar Couette flow to the Taylor vortex flow. This transition is described by a generalized Landau theory for classical second order mean-field phase transitions. The analysis of the results of carefully performed experiments not only confirms the findings of earlier experimental work, but in addition all the significant parameters of the full Davey model for this hydrodynamic instability are determied

Two-equation and multi-fluid turbulence models for Rayleigh–Taylor mixing

International Nuclear Information System (INIS)

Kokkinakis, I.W.; Drikakis, D.; Youngs, D.L.; Williams, R.J.R.

2015-01-01

Highlights: • We present a new improved version of the K–L model. • The improved K–L is found in good agreement with the multi-fluid model and ILES. • The study concerns Rayleigh–Taylor flows at initial density ratios 3:1 and 20:1. - Abstract: This paper presents a new, improved version of the K–L model, as well as a detailed investigation of K–L and multi-fluid models with reference to high-resolution implicit large eddy simulations of compressible Rayleigh–Taylor mixing. The accuracy of the models is examined for different interface pressures and specific heat ratios for Rayleigh–Taylor flows at initial density ratios 3:1 and 20:1. It is shown that the original version of the K–L model requires modifications in order to provide comparable results to the multi-fluid model. The modifications concern the addition of an enthalpy diffusion term to the energy equation; the formulation of the turbulent kinetic energy (source) term in the K equation; and the calculation of the local Atwood number. The proposed modifications significantly improve the results of the K–L model, which are found in good agreement with the multi-fluid model and implicit large eddy simulations with respect to the self-similar mixing width; peak turbulent kinetic energy growth rate, as well as volume fraction and turbulent kinetic energy profiles. However, a key advantage of the two-fluid model is that it can represent the degree of molecular mixing in a direct way, by transferring mass between the two phases. The limitations of the single-fluid K–L model as well as the merits of more advanced Reynolds-averaged Navier–Stokes models are also discussed throughout the paper.

Stability of force-free Taylor states in a new version of magnetic flux-averaged magnetohydrodynamics

International Nuclear Information System (INIS)

Pfirsch, D.; Sudan, R.N.

1996-01-01

It is observed that the recently developed magnetic flux-averaged magnetohydrodynamics (AMHD) [Phys. Plasmas 1, 2488 (1994)] is incompatible with Taylor close-quote s theorem, which states that the lowest-energy state of force-free equilibria based on the conservation of the helicity integral is absolutely stable for vanishingly small resistivity. By a modification of the Lagrangian from which AMHD is derived, a modified version of AMHD that is compatible with Taylor close-quote s theorem is obtained. It also provides an energy principle for examining the linear instability of resistive equilibria, which has a great advantage over resistive MHD. copyright 1996 American Institute of Physics

MiR-608, pre-miR-124-1 and pre-miR26a-1 polymorphisms modify susceptibility and recurrence-free survival in surgically resected CRC individuals.

Science.gov (United States)

Ying, Hou-Qun; Peng, Hong-Xin; He, Bang-Shun; Pan, Yu-Qin; Wang, Feng; Sun, Hui-Ling; Liu, Xian; Chen, Jie; Lin, Kang; Wang, Shu-Kui

2016-11-15

Genetic variation within microRNA (miRNA) may result in its abnormal folding or aberrant expression, contributing to colorectal turmorigenesis and metastasis. However, the association of six polymorphisms (miR-608 rs4919510, miR-499a rs3746444, miR-146a rs2910164, pre-miR-143 rs41291957, pre-miR-124-1 rs531564 and pre-miR-26a-1 rs7372209) with colorectal cancer (CRC) risk, therapeutic response and survival remains unclear. A retrospective study was carried out to investigate the association in 1358 0-III stage resected CRC patients and 1079 healthy controls using Sequenom's MassARRAY platform. The results showed that rs4919510 was significantly associated with a decreased susceptibility to CRC in co-dominant, allele and recessive genetic models, and the protective role of rs4919510 allele G and genotype GG was more pronounced among stage 0-II cases; significant association between rs531564 and poor RFS was observed in cases undergoing adjuvant chemo-radiotherapy in co-dominant, allele and dominant models; moreover, there was a positive association between rs7372209 and recurrence-free survival in stage II cases in co-dominant and over-dominant models; additionally, a cumulative effect of rs531564 and rs7372209 at-risk genotypes with hazard ratio at 1.30 and 1.95 for one and two at-risk genotypes was examined in stage II cases, respectively. Our findings indicated that rs4919510 allele G and genotype GG were protective factors for 0-II stage CRC, rs7372209 and rs531564 could decrease RFS in II stage individuals and resected CRC patients receiving adjuvant chemo-radiology.

Detection of Life Threatening Ventricular Arrhythmia Using Digital Taylor Fourier Transform.

Science.gov (United States)

Tripathy, Rajesh K; Zamora-Mendez, Alejandro; de la O Serna, José A; Paternina, Mario R Arrieta; Arrieta, Juan G; Naik, Ganesh R

2018-01-01

Accurate detection and classification of life-threatening ventricular arrhythmia episodes such as ventricular fibrillation (VF) and rapid ventricular tachycardia (VT) from electrocardiogram (ECG) is a challenging problem for patient monitoring and defibrillation therapy. This paper introduces a novel method for detection and classification of life-threatening ventricular arrhythmia episodes. The ECG signal is decomposed into various oscillatory modes using digital Taylor-Fourier transform (DTFT). The magnitude feature and a novel phase feature namely the phase difference (PD) are evaluated from the mode Taylor-Fourier coefficients of ECG signal. The least square support vector machine (LS-SVM) classifier with linear and radial basis function (RBF) kernels is employed for detection and classification of VT vs. VF, non-shock vs. shock and VF vs. non-VF arrhythmia episodes. The accuracy, sensitivity, and specificity values obtained using the proposed method are 89.81, 86.38, and 93.97%, respectively for the classification of Non-VF and VF episodes. Comparison with the performance of the state-of-the-art features demonstrate the advantages of the proposition.

Four Theories of the Press.

Science.gov (United States)

Siebert, Fred S.; And Others

A systematic understanding of the press requires an understanding of the social and political structures within which the press operates. This book discusses four theories that have determined the kind of press the Western world has had: authoritarian, libertarian, socially responsible, and Soviet communist. Each chapter discusses press…

WordPress 3.7 complete

CERN Document Server

Król, Karol

2013-01-01

WordPress 3.5 Complete: Third Edition is a comprehensive and step-by-step tutorial packed with screenshots and examples to make it easy and quick to pick it up.This WordPress book is a guide to WordPress for online publishers and web developers. If you are new to blogging and want to create your own blog or website from scratch, then ""WordPress 3.5 Complete: Third Edition"" is for you. No prior knowledge of HTML/CSS or PHP is required.

Glucose uptake in Azotobacter vinelandii occurs through a GluP transporter that is under the control of the CbrA/CbrB and Hfq-Crc systems.

Science.gov (United States)

Quiroz-Rocha, Elva; Moreno, Renata; Hernández-Ortíz, Armando; Fragoso-Jiménez, Juan Carlos; Muriel-Millán, Luis Felipe; Guzmán, Josefina; Espín, Guadalupe; Rojo, Fernando; Núñez, Cinthia

2017-04-12

Azotobacter vinelandii, a strict aerobic, nitrogen fixing bacterium in the Pseudomonadaceae family, exhibits a preferential use of acetate over glucose as a carbon source. In this study, we show that GluP (Avin04150), annotated as an H + -coupled glucose-galactose symporter, is the glucose transporter in A. vinelandii. This protein, which is widely distributed in bacteria and archaea, is uncommon in Pseudomonas species. We found that expression of gluP was under catabolite repression control thorugh the CbrA/CbrB and Crc/Hfq regulatory systems, which were functionally conserved between A. vinelandii and Pseudomonas species. While the histidine kinase CbrA was essential for glucose utilization, over-expression of the Crc protein arrested cell growth when glucose was the sole carbon source. Crc and Hfq proteins from either A. vinelandii or P. putida could form a stable complex with an RNA A-rich Hfq-binding motif present in the leader region of gluP mRNA. Moreover, in P. putida, the gluP A-rich Hfq-binding motif was functional and promoted translational inhibition of a lacZ reporter gene. The fact that gluP is not widely distributed in the Pseudomonas genus but is under control of the CbrA/CbrB and Crc/Hfq systems demonstrates the relevance of these systems in regulating metabolism in the Pseudomonadaceae family.

Turnerellina, a new name for Turnerella Taylor & McKinney, 2006 (Bryozoa, Cheilostomata)

NARCIS (Netherlands)

Taylor, P.D.; McKinney, F.K.

2007-01-01

Turnerella Taylor & McKinney, 2006, p. 164, introduced for a new genus of cribrimorph Cheilostomata (Bryozoa), is preoccupied by Turnerella Cockerell, 1910, a genus of Hymenoptera, and two other introductions of the same name for new insect genera. We propose Turnerellina as a new name to replace

Torque scaling in small-gap Taylor-Couette flow with smooth or grooved wall

Science.gov (United States)

Zhu, Bihai; Ji, Zengqi; Lou, Zhengkun; Qian, Pengcheng

2018-03-01

The torque in the Taylor-Couette flow for radius ratios η ≥0.97 , with smooth or grooved wall static outer cylinders, is studied experimentally, with the Reynolds number of the inner cylinder reaching up to Rei=2 ×105 , corresponding to the Taylor number up to Ta =5 ×1010 . The grooves are perpendicular to the mean flow, and similar to the structure of a submersible motor stator. It is found that the dimensionless torque G , at a given Rei and η , is significantly greater for grooved cases than smooth cases. We compare our experimental torques for the smooth cases to the fit proposed by Wendt [F. Wendt, Ing.-Arch. 4, 577 (1993), 10.1007/BF02084936] and the fit proposed by Bilgen and Boulos [E. Bilgen and R. Boulos, J Fluids Eng. 95, 122 (1973), 10.1115/1.3446944], which shows both fits are outside their range for small gaps. Furthermore, an additional dimensionless torque (angular velocity flux) N uω in the smooth cases exhibits an effective scaling of N uω˜T a0.39 in the ultimate regime, which occurs at a lower Taylor number, Ta ≈3.5 ×107 , than the well-explored η =0.714 case (at Ta ≈3 ×108 ). The same effective scaling exponent, 0.39, is also evident in the grooved cases, but for η =0.97 and 0.985, there is a peak before this exponent appears.

Recruiting community health centers into pragmatic research: Findings from STOP CRC.

Science.gov (United States)

Coronado, Gloria D; Retecki, Sally; Schneider, Jennifer; Taplin, Stephen H; Burdick, Tim; Green, Beverly B

2016-04-01

Challenges of recruiting participants into pragmatic trials, particularly at the level of the health system, remain largely unexplored. As part of Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC), we recruited eight separate community health centers (consisting of 26 individual safety net clinics) into a large comparative effectiveness pragmatic study to evaluate methods of raising the rates of colorectal cancer screening. In partnership with STOP CRC's advisory board, we defined criteria to identify eligible health centers and applied these criteria to a list of health centers in Washington, Oregon, and California affiliated with Oregon Community Health Information Network, a 16-state practice-based research network of federally sponsored health centers. Project staff contacted centers that met eligibility criteria and arranged in-person meetings of key study investigators with health center leadership teams. We used the Consolidated Framework for Implementation Research to thematically analyze the content of discussions during these meetings to identify major facilitators of and barriers to health center participation. From an initial list of 41 health centers, 11 met the initial inclusion criteria. Of these, leaders at three centers declined and at eight centers (26 clinic sites) agreed to participate (73%). Participating and nonparticipating health centers were similar with respect to clinic size, percent Hispanic patients, and percent uninsured patients. Participating health centers had higher proportions of Medicaid patients and higher baseline colorectal cancer screening rates. Common facilitators of participation were perception by center leadership that the project was an opportunity to increase colorectal cancer screening rates and to use electronic health record tools for population management. Barriers to participation were concerns of center leaders about ability to provide fecal testing to and assure follow-up of

Validation Study of Unnotched Charpy and Taylor-Anvil Impact Experiments using Kayenta

Energy Technology Data Exchange (ETDEWEB)

Kamojjala, Krishna [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lacy, Jeffrey [Idaho National Lab. (INL), Idaho Falls, ID (United States); Chu, Henry S. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Brannon, Rebecca [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-03-01

Validation of a single computational model with multiple available strain-to-failure fracture theories is presented through experimental tests and numerical simulations of the standardized unnotched Charpy and Taylor-anvil impact tests, both run using the same material model (Kayenta). Unnotched Charpy tests are performed on rolled homogeneous armor steel. The fracture patterns using Kayenta’s various failure options that include aleatory uncertainty and scale effects are compared against the experiments. Other quantities of interest include the average value of the absorbed energy and bend angle of the specimen. Taylor-anvil impact tests are performed on Ti6Al4V titanium alloy. The impact speeds of the specimen are 321 m/s and 393 m/s. The goal of the numerical work is to reproduce the damage patterns observed in the laboratory. For the numerical study, the Johnson-Cook failure model is used as the ductile fracture criterion, and aleatory uncertainty is applied to rate-dependence parameters to explore its effect on the fracture patterns.

Civil-Military Relations and Gen. Maxwell Taylor: Getting It Right and Getting It Wrong

National Research Council Canada - National Science Library

Tart, Randal

1997-01-01

... are paid. In the first situation, Taylor got his civil-military relations right, even though he fought a losing battle with President Eisenhower over Ike's dangerous defense strategy of 'massive retaliation...

Smashing WordPress Beyond the Blog

CERN Document Server

Hedengren, Thord Daniel

2011-01-01

Smashing WordPress shows you how to utilize the power of the WordPress platform, and provides a creative spark to help you build WordPress-powered sites that go beyond the obvious. The second edition of Smashing WordPress has been updated for WordPress 3.1+, which includes internal, custom post types, the admin bar, and lots of other useful new features. You will learn the core concepts used to post types, the admin bar, and lots of other useful new features. You will learn the core concepts used to build just about anything in WordPress, resulting in fast deployments and greater design flexib

Smashing WordPress Beyond the Blog

CERN Document Server

Hedengren, Thord Daniel

2012-01-01

The ultimate guide to WordPress, from the world's most popular resource for web designers and developers As one of the hottest tools on the web today for creating a blog, WordPress has evolved to be much more that just a blogging platform and has been pushed beyond its original purpose. With this new edition of a perennially popular WordPress resource, Smashing Magazine offers you the information you need so you can maximize the potential and power of WordPress. WordPress expert Thord Daniel Hedengren takes you beyond the basic blog to show you how to leverage the capabilities of WordPress to

Firm-specific investment, sticky prices and the Taylor principle

OpenAIRE

Sveen, Tommy; Weinke, Lutz

2005-01-01

According to the Taylor principle a central bank should adjust the nominal interest rate by more than one-for-one in response to changes in current inflation. Most of the existing literature supports the view that by following this simple recommendation a central bank can avoid being a source of unnecessary fluctuations in economic activity. The present paper shows that this conclusion is not robust with respect to the modelling of capital accumulation. We use our insights to discuss the desi...

The Ekman-Hartmann layer in MHD Taylor-Couette flow

OpenAIRE

Szklarski, Jacek; Rüdiger, Günther

2007-01-01

We study magnetic effects induced by rigidly rotating plates enclosing a cylindrical MHD Taylor-Couette flow at the finite aspect ratio $H/D=10$. The fluid confined between the cylinders is assumed to be liquid metal characterized by small magnetic Prandtl number, the cylinders are perfectly conducting, an axial magnetic field is imposed $\\Ha \\approx 10$, the rotation rates correspond to $\\Rey$ of order $10^2-10^3$. We show that the end-plates introduce, besides the well known Ekman circulati...

Taylor-Couette flow stability with toroidal magnetic field

International Nuclear Information System (INIS)

Shalybkov, D

2005-01-01

The linear stability of the dissipative Taylor-Couette flow with imposed azimuthal magnetic field is considered. Unlike to ideal flow, the magnetic field is fixed function of radius with two parameters only: a ratio of inner to outer cylinder radii and a ratio of the magnetic field values on outer and inner cylinders. The magnetic field with boundary values ratio greater than zero and smaller than inverse radii ratio always stabilizes the flow and called stable magnetic field below. The current free magnetic field is the stable magnetic field. The unstable magnetic field destabilizes every flow if the magnetic field (or Hartmann number) exceeds some critical value. This instability survives even without rotation (for zero Reynolds number). For the stable without the magnetic field flow, the unstable modes are located into some interval of the vertical wave numbers. The interval length is zero for critical Hartmann number and increases with increasing Hartmann number. The critical Hartmann numbers and the length of the unstable vertical wave numbers interval is the same for every rotation law. There are the critical Hartmann numbers for m = 0 sausage and m = 1 kink modes only. The critical Hartmann numbers are smaller for kink mode and this mode is the most unstable mode like to the pinch instability case. The flow stability do not depend on the magnetic Prandtl number for m = 0 mode. The same is true for critical Hartmann numbers for m = 0 and m = 1 modes. The typical value of the magnetic field destabilizing the liquid metal Taylor-Couette flow is order of 100 Gauss

Mode coupling in nonlinear Rayleigh--Taylor instability

International Nuclear Information System (INIS)

Ofer, D.; Shvarts, D.; Zinamon, Z.; Orszag, S.A.

1992-01-01

This paper studies the interaction of a small number of modes in the two-fluid Rayleigh--Taylor instability at relatively late stages of development, i.e., the nonlinear regime, using a two-dimensional hydrodynamic code incorporating a front-tracking scheme. It is found that the interaction of modes can greatly affect the amount of mixing and may even reduce the width of the mixing region. This interaction is both relatively long range in wave-number space and also acts in both directions, i.e., short wavelengths affect long wavelengths and vice versa. Three distinct stages of interaction have been identified, including substantial interaction among modes some of which may still be in their classical (single mode) ''linear'' phase

Muscle activation when performing the chest press and shoulder press on a stable bench vs. a Swiss ball.

Science.gov (United States)

Uribe, Brandon P; Coburn, Jared W; Brown, Lee E; Judelson, Daniel A; Khamoui, Andy V; Nguyen, Diamond

2010-04-01

The aim of this study was to examine the effects of a stable surface (bench) vs. an unstable surface (Swiss ball) on muscle activation when performing the dumbbell chest press and shoulder press. Sixteen healthy men (24.19 +/- 2.17 years) performed 1 repetition maximum (1RM) tests for the chest press and shoulder press on a stable surface. A minimum of 48 hours post 1RM, subjects returned to perform 3 consecutive repetitions each of the chest press and shoulder press at 80% 1RM under 4 different randomized conditions (chest press on bench, chest press on Swiss ball, shoulder press on bench, shoulder press on Swiss ball). Electromyography was used to assess muscle activation of the anterior deltoid, pectoralis major, and rectus abdominus. The results revealed no significant difference in muscle activation between surface types for either exercise. This suggests that using an unstable surface neither improves nor impairs muscle activation under the current conditions. Coaches and other practitioners can expect similar muscle activation when using a Swiss ball vs. a bench.

Rayleigh-Taylor-instability evolution in colliding-plasma-jet experiments with magnetic and viscous stabilization

Energy Technology Data Exchange (ETDEWEB)

Adams, Colin Stuart [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Univ. of New Mexico, Albuquerque, NM (United States); Univ. of Washington, Seattle, WA (United States)

2015-01-15

The Rayleigh-Taylor instability causes mixing in plasmas throughout the universe, from micron-scale plasmas in inertial confinement fusion implosions to parsec-scale supernova remnants. The evolution of this interchange instability in a plasma is influenced by the presence of viscosity and magnetic fields, both of which have the potential to stabilize short-wavelength modes. Very few experimental observations of Rayleigh-Taylor growth in plasmas with stabilizing mechanisms are reported in the literature, and those that are reported are in sub-millimeter scale plasmas that are difficult to diagnose. Experimental observations in well-characterized plasmas are important for validation of computational models used to make design predictions for inertial confinement fusion efforts. This dissertation presents observations of instability growth during the interaction between a high Mach-number, initially un-magnetized plasma jet and a stagnated, magnetized plasma. A multi-frame fast camera captures Rayleigh-Taylor-instability growth while interferometry, spectroscopy, photodiode, and magnetic probe diagnostics are employed to estimate plasma parameters in the vicinity of the collision. As the instability grows, an evolution to longer mode wavelength is observed. Comparisons of experimental data with idealized magnetohydrodynamic simulations including a physical viscosity model suggest that the observed instability evolution is consistent with both magnetic and viscous stabilization. These data provide the opportunity to benchmark computational models used in astrophysics and fusion research.

Experiment of ablative Rayleigh-Taylor instability in a strongly non linear regime on the National Ignition Facility

International Nuclear Information System (INIS)

Casner, A.; Masse, L.; Liberatore, S.; Delorme, B.; Jacquet, L.; Loiseau, P.; Smalyuk, V. A.; Martinez, D.; Remington, B. A.

2012-01-01

As the control of the development of Rayleigh-Taylor-type hydrodynamic instabilities is crucial to achieve efficient implosions on the Laser Megajoule, and as the complexity of these instabilities requires an experimental validation of theoretical models and of the associated numerical simulations, the authors briefly present a proposition of experiments aimed at studying the strongly non linear Rayleigh-Taylor instability on the National Ignition Facility (NIF). This should allow a regime of competition between bubbles to be achieved for the first time in direct attack. They evoke the first experiment performed in March 2013

Equation of state at finite net-baryon density using Taylor coefficients up to sixth order

International Nuclear Information System (INIS)

Huovinen, Pasi; Petreczky, Péter; Schmidt, Christian

2014-01-01

We employ the lattice QCD data on Taylor expansion coefficients up to sixth order to construct an equation of state at finite net-baryon density. When we take into account how hadron masses depend on lattice spacing and quark mass, the coefficients evaluated using the p4 action are equal to those of hadron resonance gas at low temperature. Thus the parametrised equation of state can be smoothly connected to the hadron resonance gas equation of state. We see that the equation of state using Taylor coefficients up to second order is realistic only at low densities, and that at densities corresponding to s/n B ≳40, the expansion converges by the sixth order term

Investing in a Large Stretch Press

Science.gov (United States)

Choate, M.; Nealson, W.; Jay, G.; Buss, W.

1986-01-01

Press for forming large aluminum parts from plates provides substantial economies. Study assessed advantages and disadvantages of investing in large stretch-forming press, and also developed procurement specification for press.

Self-consistent model of the Rayleigh--Taylor instability in ablatively accelerated laser plasma

International Nuclear Information System (INIS)

Bychkov, V.V.; Golberg, S.M.; Liberman, M.A.

1994-01-01

A self-consistent approach to the problem of the growth rate of the Rayleigh--Taylor instability in laser accelerated targets is developed. The analytical solution of the problem is obtained by solving the complete system of the hydrodynamical equations which include both thermal conductivity and energy release due to absorption of the laser light. The developed theory provides a rigorous justification for the supplementary boundary condition in the limiting case of the discontinuity model. An analysis of the suppression of the Rayleigh--Taylor instability by the ablation flow is done and it is found that there is a good agreement between the obtained solution and the approximate formula σ = 0.9√gk - 3u 1 k, where g is the acceleration, u 1 is the ablation velocity. This paper discusses different regimes of the ablative stabilization and compares them with previous analytical and numerical works

Chebyshev-Taylor Parameterization of Stable/Unstable Manifolds for Periodic Orbits: Implementation and Applications

Science.gov (United States)

Mireles James, J. D.; Murray, Maxime

2017-12-01

This paper develops a Chebyshev-Taylor spectral method for studying stable/unstable manifolds attached to periodic solutions of differential equations. The work exploits the parameterization method — a general functional analytic framework for studying invariant manifolds. Useful features of the parameterization method include the fact that it can follow folds in the embedding, recovers the dynamics on the manifold through a simple conjugacy, and admits a natural notion of a posteriori error analysis. Our approach begins by deriving a recursive system of linear differential equations describing the Taylor coefficients of the invariant manifold. We represent periodic solutions of these equations as solutions of coupled systems of boundary value problems. We discuss the implementation and performance of the method for the Lorenz system, and for the planar circular restricted three- and four-body problems. We also illustrate the use of the method as a tool for computing cycle-to-cycle connecting orbits.

Effect of CRC::etr1-1 transgene expression on ethylene production, sex expression, fruit set and fruit ripening in transgenic melon (Cucumis melo L.).

Science.gov (United States)

Switzenberg, Jessica A; Beaudry, Randy M; Grumet, Rebecca

2015-06-01

Ethylene is a key factor regulating sex expression in cucurbits. Commercial melons (Cucumis melo L.) are typically andromonoecious, producing male and bisexual flowers. Our prior greenhouse studies of transgenic melon plants expressing the dominant negative ethylene perception mutant gene, etr1-1, under control of the carpel- and nectary-primordia targeted CRAB'S CLAW (CRC) promoter showed increased number and earlier appearance of carpel-bearing flowers. To further investigate this phenomenon which could be potentially useful for earlier fruit production, we observed CRC::etr1-1 plants in the field for sex expression, fruit set, fruit development, and ripening. CRC::etr1-1 melon plants showed increased number of carpel-bearing open flowers on the main stem and earlier onset by 7-10 nodes. Additional phenotypes observed in the greenhouse and field were conversion of approximately 50% of bisexual buds to female, and elongated ovaries and fruits. Earlier and greater fruit set occurred on the transgenic plants. However, CRC::etr1-1 plants had greater abscission of young fruit, and smaller fruit, so that final yield (kg/plot) was equivalent to wild type. Earlier fruit set in line M5 was accompanied by earlier appearance of ripe fruit. Fruit from line M15 frequently did not exhibit external ripening processes of rind color change and abscission, but when cut open, the majority showed a ripe or overripe interior accompanied by elevated internal ethylene. The non-ripening external phenotype in M15 fruit corresponded with elevated etr1-1 transgene expression in the exocarp. These results provide insight into the role of ethylene perception in carpel-bearing flower production, fruit set, and ripening.

AUPress: A Comparison of an Open Access University Press with Traditional Presses

Science.gov (United States)

McGreal, Rory; Chen, Nian-Shing

2011-01-01

This study is a comparison of AUPress with three other traditional (non-open access) Canadian university presses. The analysis is based on the rankings that are correlated with book sales on Amazon.com and Amazon.ca. Statistical methods include the sampling of the sales ranking of randomly selected books from each press. The results of one-way…

Predicting Outcome and Therapy Response in mCRC Patients Using an Indirect Method for CTCs Detection by a Multigene Expression Panel: A Multicentric Prospective Validation Study

Directory of Open Access Journals (Sweden)

Yolanda Vidal Insua

2017-06-01

Full Text Available Colorectal cancer (CRC is one of the major causes of cancer-related deaths. Early detection of tumor relapse is crucial for determining the most appropriate therapeutic management. In clinical practice, computed tomography (CT is routinely used, but small tumor changes are difficult to visualize, and reliable blood-based prognostic and monitoring biomarkers are urgently needed. The aim of this study was to prospectively validate a gene expression panel (composed of GAPDH, VIL1, CLU, TIMP1, TLN1, LOXL3 and ZEB2 for detecting circulating tumor cells (CTCs as prognostic and predictive tool in blood samples from 94 metastatic CRC (mCRC patients. Patients with higher gene panel expression before treatment had a reduced progression-free survival (PFS and overall-survival (OS rates compared with patients with low expression (p = 0.003 and p ≤ 0.001, respectively. Patients with increased expression of CTCs markers during treatment presented PFS and OS times of 8.95 and 11.74 months, respectively, compared with 14.41 and 24.7 for patients presenting decreased expression (PFS; p = 0.020; OS; p ≤ 0.001. Patients classified as non-responders by CTCs with treatment, but classified as responders by CT scan, showed significantly shorter survival times (PFS: 8.53 vs. 11.70; OS: 10.37 vs. 24.13; months. In conclusion, our CTCs detection panel demonstrated efficacy for early treatment response assessment in mCRC patients, and with increased reliability compared to CT scan.

Numerical simulation of Rayleigh-Taylor instability in ablation driven systems

International Nuclear Information System (INIS)

Verdon, C.P.

1984-01-01

Two-dimensional numerical simulations of ablatively accelerated thin shells subject to Rayleigh-Taylor instability are presented. Results for both single wavelength and multiwavelength perturbations show that the nonlinear effects of the instability are evident mainly in the bubble rather than the spike. Approximate roles for predicting the dominant nonlinear mode-mode interactions, which limit shell performance, are also discussed. The work concludes with a discussion of recommendations for future work in this area

FLANDES, Flange Design for He Circuits by Taylor-Forge Method

International Nuclear Information System (INIS)

Pitchford, B.E.

1977-01-01

1 - Nature of the physical problem solved: Flange design for helium circuits. 2 - Method of solution: This is a flange design programme based on the Taylor forge method with an additional calculation of flange rotation and bolt load change during the application of internal pressure. The method relates only to the integral hub type of flange, with or without a secondary O-ring seal but will deal also with the flange and cover plate case

Professional WordPress design and development

CERN Document Server

Williams, Brad; Stern, Hal

2014-01-01

The highest rated WordPress development and design book on the market is back with an all new third edition. Professional WordPress is the only WordPress book targeted to developers, with advanced content that exploits the full functionality of the most popular CMS in the world. Fully updated to align with WordPress 4.1, this edition has updated examples with all new screenshots, and full exploration of additional tasks made possible by the latest tools and features. You will gain insight into real projects that currently use WordPress as an application framework, as well as the basic usage a

The World of Barilla Taylor: Bringing History to Life through Primary Sources.

Science.gov (United States)

Stearns, Liza

1997-01-01

Presents a lesson plan using material from a primary source-based curriculum kit titled "The World of Barilla Taylor." The kit uses personal letters, maps, hospital and work records, and other primary sources to document the life of a young woman working in the textile mills in 19th-century Massachusetts. (MJP)

BuddyPress theme development

CERN Document Server

Lister, Tammie

2013-01-01

This book is a hands-on tutorial guide to using BuddyPress.This book is great for designers and developers who are looking to learn how to develop BuddyPress themes. It's assumed that the reader has some understanding of Wordpress and is familiar with CSS and HTML.

Effect on Non-Newtonian Rheology on Mixing in Taylor-Couette Flow

Science.gov (United States)

Cagney, Neil; Balabani, Stavroula

2017-11-01

Mixing processes within many industry applications are strongly affected by the rheology of the working fluid. This is particularly relevant for pharmaceutical, food and waste treatment industries, where the working fluids are often strongly non-Newtonian, and significant variations in rheology between batches may occur. We approach the question of how rheology affects mixing by focussing on a the classical case of Taylor-Couette flow, which exhibits a number of instabilities and flow regimes as a function of Reynolds number. We examine Taylor-Couette flow generated for a range of aqueous solutions of xantham gum or corn starch, such that the rheology varies from shear-thinning to shear-thickening. For each case, we measure the power consumption using a torque meter and the flow field using high speed, time-resolved Particle-Image Velocimetry. The mixing characteristics are quantified using a number of Lagrangian and Eulerian approaches, including the coarse grained density method and vortex strength. By comparing these metrics to the power number, we discuss how the mixing efficiency (ratio of mixing effectiveness to power input) varies with the flow index of the fluid.

The Taylor-expansion method of moments for the particle system with bimodal distribution

Directory of Open Access Journals (Sweden)

Liu Yan-Hua

2013-01-01

Full Text Available This paper derives the multipoint Taylor expansion method of moments for the bimodal particle system. The collision effects are modeled by the internal and external coagulation terms. Simple theory and numerical tests are performed to prove the effect of the current model.

Conférence de presse | Press Conference

CERN Multimedia

CERN. Geneva; Bejar Alonso, Isabel

2018-01-01

10:00-11:00 Conférence de presse en présence de Lucio Rossi, chef du projet LHC à Haute Luminosité et Isabel Bejar Alonso, chargée de la configuration, de la qualité et des ressources du projet LHC à Haute Luminosité.

MICROBIAL BIOFILMS AS INTEGRATIVE SENSORS OF ENVIRONMENTAL QUALITY

Science.gov (United States)

Snyder, Richard A., Michael A. Lewis, Andreas Nocker and Joe E. Lepo. In press. Microbial Biofilms as Integrative Sensors of Environmental Quality. In: Estuarine Indicators Workshop Proceedings. CRC Press, Boca Raton, FL. 34 p. (ERL,GB 1198). Microbial biofilms are comple...

Statistical approach of weakly nonlinear ablative Rayleigh-Taylor instability

International Nuclear Information System (INIS)

Garnier, J.; Masse, L.

2005-01-01

A weakly nonlinear model is proposed for the Rayleigh-Taylor instability in presence of ablation and thermal transport. The nonlinear effects for a single-mode disturbance are computed, included the nonlinear correction to the exponential growth of the fundamental modulation. Mode coupling in the spectrum of a multimode disturbance is thoroughly analyzed by a statistical approach. The exponential growth of the linear regime is shown to be reduced by the nonlinear mode coupling. The saturation amplitude is around 0.1λ for long wavelengths, but higher for short instable wavelengths in the ablative regime

Comments on the Huang and Taylor model of ion-implanted silicon-gate depletion-mode IGFET

International Nuclear Information System (INIS)

Marciniak, W.; Madura, H.

1985-01-01

Recently the Huang and Taylor model (HT model) of built-in channel MOS transistors has been widely used in the analysis of electronic circuits because of its relative simplicity. Huang and Taylor assumed that the effects of the finite channel thickness may be represented by an average semiconductor capacitance in series with the gate oxide capacitance. The derivation of the current-voltage characteristics is based on a linear equation of surface depleted charge density Qsub(s), which is calculated as the sheet charge of constant capacitance C-bar. This is done instead of using the exact solution of the Poisson equation, which has a rather complex form of nonlinear relationship between the charge Qsub(s) and the gate voltage. The basic equation is given. (author)

Taylor expansion of luminosity distance in Szekeres cosmological models: effects of local structures evolution on cosmographic parameters

Energy Technology Data Exchange (ETDEWEB)

Villani, Mattia, E-mail: villani@fi.infn.it [Sezione INFN di Firenze, Polo Scientifico Via Sansone 1, 50019, Sesto Fiorentino (Italy)

2014-06-01

We consider the Goode-Wainwright representation of the Szekeres cosmological models and calculate the Taylor expansion of the luminosity distance in order to study the effects of the inhomogeneities on cosmographic parameters. Without making a particular choice for the arbitrary functions defining the metric, we Taylor expand up to the second order in redshift for Family I and up to the third order for Family II Szekeres metrics under the hypotesis, based on observation, that local structure formation is over. In a conservative fashion, we also allow for the existence of a non null cosmological constant.