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Sample records for core loading pattern

  1. Machine Learning of the Reactor Core Loading Pattern Critical Parameters

    Directory of Open Access Journals (Sweden)

    Krešimir Trontl

    2008-01-01

    Full Text Available The usual approach to loading pattern optimization involves high degree of engineering judgment, a set of heuristic rules, an optimization algorithm, and a computer code used for evaluating proposed loading patterns. The speed of the optimization process is highly dependent on the computer code used for the evaluation. In this paper, we investigate the applicability of a machine learning model which could be used for fast loading pattern evaluation. We employ a recently introduced machine learning technique, support vector regression (SVR, which is a data driven, kernel based, nonlinear modeling paradigm, in which model parameters are automatically determined by solving a quadratic optimization problem. The main objective of the work reported in this paper was to evaluate the possibility of applying SVR method for reactor core loading pattern modeling. We illustrate the performance of the solution and discuss its applicability, that is, complexity, speed, and accuracy.

  2. MTR core loading pattern optimization using burnup dependent group constants

    Directory of Open Access Journals (Sweden)

    Iqbal Masood

    2008-01-01

    Full Text Available A diffusion theory based MTR fuel management methodology has been developed for finding superior core loading patterns at any stage for MTR systems, keeping track of burnup of individual fuel assemblies throughout their history. It is based on using burnup dependent group constants obtained by the WIMS-D/4 computer code for standard fuel elements and control fuel elements. This methodology has been implemented in a computer program named BFMTR, which carries out detailed five group diffusion theory calculations using the CITATION code as a subroutine. The core-wide spatial flux and power profiles thus obtained are used for calculating the peak-to-average power and flux-ratios along with the available excess reactivity of the system. The fuel manager can use the BFMTR code for loading pattern optimization for maximizing the excess reactivity, keeping the peak-to-average power as well as flux-ratio within constraints. The results obtained by the BFMTR code have been found to be in good agreement with the corresponding experimental values for the equilibrium core of the Pakistan Research Reactor-1.

  3. Performance evaluation of PSO and GA in PWR core loading pattern optimization

    Energy Technology Data Exchange (ETDEWEB)

    Khoshahval, F., E-mail: f_khoshahval@sbu.ac.i [Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Velenjak, Tehran (Iran, Islamic Republic of); Minuchehr, H. [Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Velenjak, Tehran (Iran, Islamic Republic of); Zolfaghari, A., E-mail: a-zolfaghari@sbu.ac.i [Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Velenjak, Tehran (Iran, Islamic Republic of)

    2011-03-15

    Research highlights: The performance of both GA and PSO methods in optimizing of a PWR core are adequate. It seems GA arrives to its final parameter value in a fewer generation than the PSO. The computation time for GA is higher than PSO. The GA-2 and PSO-CFA algorithms perform better in comparison to GA-1 and PSO-IWA. - Abstract: The efficient operation and fuel management of PWRs are of utmost importance. Recently, genetic algorithm (GA) and particle swarm optimization (PSO) techniques have attracted considerable attention among various modern heuristic optimization techniques. GA is a powerful optimization technique, based upon the principles of natural selection and species evolution. GA is finding popularity as design tools because of its versatility, intuitiveness and ability to solve highly non-linear, mixed integer optimization problems. PSO refers to a relatively new family of algorithms and is mainly inspired by social behavior patterns of organisms that live within large group. This study addresses the application and performance comparison of PSO and GA optimization methods for nuclear fuel loading pattern problem. Flattening of power inside the reactor core of Bushehr nuclear power plant (WWER-1000 type) is chosen as an objective function to prove the validity of algorithms. In addition the performance of both optimization techniques in terms of convergence rate and computational time is compared. It is found that, from an evolutionary point of view, the performance of both GA and PSO is quite adequate. But, GA seems to arrive at its final parameter value in a fewer generations than the PSO. It is also noticed that, the computation time for implemented GA in this work is too high in comparison to PSO.

  4. Honeycomb Core Permeability Under Mechanical Loads

    Science.gov (United States)

    Glass, David E.; Raman, V. V.; Venkat, Venki S.; Sankaran, Sankara N.

    1997-01-01

    A method for characterizing the air permeability of sandwich core materials as a function of applied shear stress was developed. The core material for the test specimens was either Hexcel HRP-3/16-8.0 and or DuPont Korex-1/8-4.5 and was nominally one-half inch thick and six inches square. The facesheets where made of Hercules' AS4/8552 graphite/epoxy (Gr/Ep) composites and were nominally 0.059-in. thick. Cytec's Metalbond 1515-3M epoxy film adhesive was used for co-curing the facesheets to the core. The permeability of the specimens during both static (tension) and dynamic (reversed and non-reversed) shear loads were measured. The permeability was measured as the rate of air flow through the core from a circular 1-in2 area of the core exposed to an air pressure of 10.0 psig. In both the static and dynamic testing, the Korex core experienced sudden increases in core permeability corresponding to a core catastrophic failure, while the URP core experienced a gradual increase in the permeability prior to core failure. The Korex core failed at lower loads than the HRP core both in the transverse and ribbon directions.

  5. Lateral load pattern in pushover analysis

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The seismic capacity curves of three types of buildings including frame, frame-shear wall and shear wall obtained by pushover analysis under different lateral load patterns are compared with those from nonlinear time history analysis. Based on the numerical results obtained a two-phase load pattern: an inverted triangle(first mode)load pattern until the base shear force reaches β times its maximum value,Vmax, followed by a(x/H)α form, here β and α being some coefficients depending on the type of the structures considered, is proposed in the paper, which can provide excellent approximation of the seismic capacity curve for low-to-mid-rise shear type buildings. Furthermore, it is shown both the two-phase load pattern proposed and the invariant uniform pattern can be used for low-to-mid-rise shear-bending type and low-rise bending type of buildings. No suitable load patterns have been found for high-rise buildings.

  6. Continuous firefly algorithm applied to PWR core pattern enhancement

    Energy Technology Data Exchange (ETDEWEB)

    Poursalehi, N., E-mail: npsalehi@yahoo.com [Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Tehran (Iran, Islamic Republic of); Zolfaghari, A.; Minuchehr, A.; Moghaddam, H.K. [Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Tehran (Iran, Islamic Republic of)

    2013-05-15

    Highlights: ► Numerical results indicate the reliability of CFA for the nuclear reactor LPO. ► The major advantages of CFA are its light computational cost and fast convergence. ► Our experiments demonstrate the ability of CFA to obtain the near optimal loading pattern. -- Abstract: In this research, the new meta-heuristic optimization strategy, firefly algorithm, is developed for the nuclear reactor loading pattern optimization problem. Two main goals in reactor core fuel management optimization are maximizing the core multiplication factor (K{sub eff}) in order to extract the maximum cycle energy and minimizing the power peaking factor due to safety constraints. In this work, we define a multi-objective fitness function according to above goals for the core fuel arrangement enhancement. In order to evaluate and demonstrate the ability of continuous firefly algorithm (CFA) to find the near optimal loading pattern, we developed CFA nodal expansion code (CFANEC) for the fuel management operation. This code consists of two main modules including CFA optimization program and a developed core analysis code implementing nodal expansion method to calculate with coarse meshes by dimensions of fuel assemblies. At first, CFA is applied for the Foxholes test case with continuous variables in order to validate CFA and then for KWU PWR using a decoding strategy for discrete variables. Results indicate the efficiency and relatively fast convergence of CFA in obtaining near optimal loading pattern with respect to considered fitness function. At last, our experience with the CFA confirms that the CFA is easy to implement and reliable.

  7. Revisiting Multiple Pattern Matching Algorithms for Multi-Core Architecture

    Institute of Scientific and Technical Information of China (English)

    Guang-Ming Tan; Ping Liu; Dong-Bo Bu; Yan-Bing Liu

    2011-01-01

    Due to the huge size of patterns to be searched,multiple pattern searching remains a challenge to several newly-arising applications like network intrusion detection.In this paper,we present an attempt to design efficient multiple pattern searching algorithms on multi-core architectures.We observe an important feature which indicates that the multiple pattern matching time mainly depends on the number and minimal length of patterns.The multi-core algorithm proposed in this paper leverages this feature to decompose pattern set so that the parallel execution time is minimized.We formulate the problem as an optimal decomposition and scheduling of a pattern set,then propose a heuristic algorithm,which takes advantage of dynamic programming and greedy algorithmic techniques,to solve the optimization problem.Experimental results suggest that our decomposition approach can increase the searching speed by more than 200% on a 4-core AMD Barcelona system.

  8. CMP dummy pattern based on VSB writer load

    Science.gov (United States)

    Sakata, Wakahiko; Osawa, Isaku; Narukawa, Shogo; Takikawa, Tadahiko; Mohri, Hiroshi

    2010-05-01

    The load of VSB-EB mask writers has significantly increased since particularly RET/OPC and CMP dummy pattern generation technologies were widely adopted into designs at advanced nodes, with the result that the volume of mask data patterns was increased exponentially. In order to reduce the load of VSB mask writer, we've focused on CMP dummy patterns and developed a method of reducing CMP dummy pattern, which can smartly write CMP dummy patterns without not only deteriorating the CMP effects by them and also increasing the total number of the mask writer's shot count. To that end, we are aiming to establish a VSB-mask-writer-friendly CMP dummy pattern generation flow with CMP simulator developers by providing a mask writer parameter for them. This paper shows the first experimental results of our mask writer's load reduction work.

  9. Core losses of an inverter-fed permanent magnet synchronous motor with an amorphous stator core under no-load

    OpenAIRE

    Nicolas Denis; Yoshiyuki Kato; Masaharu Ieki; Keisuke Fujisaki

    2016-01-01

    In this paper, an interior permanent magnet synchronous motor (IPMSM) with a stator core made of amorphous magnetic material (AMM) is presented. The IPMSM is driven by a voltage source three-phase inverter with classical pulse width modulation (PWM) control. The core losses under no-load condition are measured by experiment and compared to an equivalent IPMSM with a stator core made of NO steel. Under these conditions, the core losses are influenced by the stator, rotor and magnet shapes but ...

  10. Error detection in core loading in the condition of asymmetrical distribution of power

    Energy Technology Data Exchange (ETDEWEB)

    Ryzhov, Andrei; Pinegin, Anatoly [National Research Centre ' Kurchatov Institute' , Moscow (Russian Federation)

    2016-09-15

    The error detection in core loading in many cases happens in conditions of a significant asymmetry in the distribution of power density, which is caused by thermal mechanical deformations of reactor core, and temperature differences in the cold legs of coolant. The asymmetry of power distribution essentially decreases the effectiveness of algorithms used to detect errors in the core loading using ICIS data. The paper proposes the ways for solving this problem by means of special filtration algorithms.

  11. Fluorophore-cored dendrimers for patterns in metalloprotein sensing.

    Science.gov (United States)

    Jiwpanich, Siriporn; Sandanaraj, Britto S; Thayumanavan, S

    2009-02-21

    In fluorophore-cored dendrimers with peripheral binding functionalities, the effect of generation upon protein binding-induced fluorescence quenching can be unpredictable; this is because the increase in fluorophore-binding functionality distance with generation is also accompanied by an increase in the number of binding moieties and the interplay between the two features is utilized to create patterns for metalloprotein sensing.

  12. MA-core loaded untuned RF compression cavity for HIRFL-CSR

    Science.gov (United States)

    Mei, Li-rong; Xu, Zhe; Yuan, You-jin; Jin, Peng; Bian, Zhi-bin; Zhao, Hong-wei; Xia, Jia-wen

    2012-01-01

    To meet the requirements of high energy density physics and plasma physics research at HIRFL-CSR the goal of achieving a higher accelerating gap voltage was proposed. Therefore, a magnetic alloy (MA)-core loaded radio frequency (RF) cavity that can provide a higher accelerating gap voltage compared to standard ferrite loaded cavities has been studied at IMP. In order to select the proper magnetic alloy material to load the RF compression cavity, measurements of four different kinds of sample MA-cores have been carried out. By testing the small cores, the core composition was selected to obtain the desired performance. According to the theoretical calculation and simulation, which show reasonable consistency for the MA-core loaded cavity, the desired performance can be achieved. Finally about 1000 kW power will be needed to meet the requirements of 50 kV accelerating gap voltage by calculation.

  13. Core losses of an inverter-fed permanent magnet synchronous motor with an amorphous stator core under no-load

    Directory of Open Access Journals (Sweden)

    Nicolas Denis

    2016-05-01

    Full Text Available In this paper, an interior permanent magnet synchronous motor (IPMSM with a stator core made of amorphous magnetic material (AMM is presented. The IPMSM is driven by a voltage source three-phase inverter with classical pulse width modulation (PWM control. The core losses under no-load condition are measured by experiment and compared to an equivalent IPMSM with a stator core made of NO steel. Under these conditions, the core losses are influenced by the stator, rotor and magnet shapes but also by the PWM carrier signal that implies a high frequency harmonic in the magnetic flux density. It is demonstrated that the AMM can reduce the core losses by about 56 %.

  14. Residual dent in locally loaded foam core sandwich structures – Analysis and use for NDI

    NARCIS (Netherlands)

    Koysin, V.; Shipsha, Andrey

    2008-01-01

    This paper addresses the residual denting in the face sheet and corresponding core damage in a locally loaded flat sandwich structure with foam core. The problem is analytically considered in the context of elastic bending of the face sheet accompanied by non-linear deformation of the crushed foam

  15. Capacitively Loaded Loop-Based Antennas with Reconfigurable Radiation Patterns

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    Saber Dakhli

    2015-01-01

    Full Text Available A class of metamaterial-inspired antennas having reconfigurable radiation patterns is proposed. They consist of a driven monopole antenna with one- and two-capacitively loaded loop (CLL, near field resonant parasitic elements. Two configurations are studied by considering the state of these CLL elements as being either open or closed configurations. Simulation results explain the design features and demonstrate that the structure can change its beam direction simply by controlling the switched states. Two prototypes with one- and two-CLL elements were fabricated and tested. The measured impedance mismatch and radiation pattern results are presented and compared to the corresponding simulated values.

  16. Demand Flexibility Time Intervals for Aggregate Residential Load Patterns

    OpenAIRE

    Sajjad, Intisar A.; CHICCO Gianfranco; Napoli, Roberto

    2015-01-01

    This paper deals with the definition of demand flexibility time intervals. These intervals are extracted from the binomial probability model of load variation patterns with the two possible categories of increase and non-increase in demand. These intervals along with the information on the coefficient of variation of the aggregate demand are used to assess the potential of demand flexibility exhibited by the aggregate residential demand in different periods of the day. The results of the prop...

  17. Aerosol loading impact on Asian monsoon precipitation patterns

    Science.gov (United States)

    Biondi, Riccardo; Cagnazzo, Chiara; Costabile, Francesca; Cairo, Francesco

    2017-04-01

    Solar light absorption by aerosols such as black carbon and dust assume a key role in driving the precipitation patterns in the Indian subcontinent. The aerosols stack up against the foothills of the Himalayas in the pre-monsoon season and several studies have already demonstrated that this can cause precipitation anomalies during summer. Despite its great significance in climate change studies, the link between absorbing aerosols loading and precipitation patterns remains highly uncertain. The main challenge for this kind of studies is to find consistent and reliable datasets. Several aerosol time series are available from satellite and ground based instruments and some precipitation datasets from satellite sensors, but they all have different time/spatial resolution and they use different assumptions for estimating the parameter of interest. We have used the aerosol estimations from the Ozone Monitoring Instrument (OMI), the Along-Track Scanning Radiometer (AATSR) and the MODerate resolution Imaging Spectroradiometer (MODIS) and validated them against the Aerosol Robotic Network (AERONET) measurements in the Indian area. The precipitation has been analyzed by using the Tropical Rainfall Measuring Mission (TRMM) estimations and the Modern-Era Retrospective analysis for Research and Applications version 2 (MERRA-2). From our results it is evident the discrepancy between the aerosol loading on the area of interest from the OMI, AATSR, and MODIS, but even between 3 different algorithms applied to the MODIS data. This uncertainty does not allow to clearly distinguishing high aerosol loading years from low aerosol loading years except in a couple of cases where all the estimations agree. Similar issues are also present in the precipitation estimations from TRMM and MERRA-2. However, all the aerosol datasets agree in defining couples of consecutive years with a large gradient of aerosol loading. Based on this assumption we have compared the precipitation anomalies and

  18. The Effect of Cyclic Loading on the Compressive Strength of Core Build-Up Materials.

    Science.gov (United States)

    Zankuli, Muayed A; Silikas, Nick; Devlin, Hugh

    2015-01-15

    To evaluate the effect of cyclic loading on compressive strength of core build-up materials. Four dual-cured composites (Core.X Flow, Grandio Core, Bright Flow Core, Spee-Dee) and one light-cured reinforced resin-modified glass ionomer (Fuji II LC) were tested. One hundred cylindrical specimens (4 mm × 6 mm) were prepared. Each material had two groups (ten specimens to be tested under static loading and ten specimens to be tested after cyclic loading). The specimens were stored wet, and after 30 days, one group of each material was cyclically loaded (for 250,000 cycles with a frequency of 1.6 Hz under stress load of 68.6 N) in a chewing simulator CS-4.2. Then specimens were subjected to static compressive loading until failure in a universal testing machine. Mean compressive strength values before cycling ranged from 144 MPa (15.8) for Fuji II LC to 277 MPa (23.2) for Grandio Core. Independent t-test showed no statistically significant difference (p > 0.05) in the compressive strength of each material before and after cycling (p = 0.7 Grandio Core, p = 0.3 Core.X Flow, p = 0.6 Bright Flow Core, p = 0.2 Spee-Dee, p = 0.6 Fuji II LC); however, there was a statistically significant difference between the materials when comparing before and after cycling. All tested materials showed no reduction in the compressive strength after cycling. Therefore, the tested materials can survive 1 year in service without a reduction in compressive strength. © 2015 by the American College of Prosthodontists.

  19. Influence of modification in core building procedure on fracture strength and failure patterns of premolars restored with fiber post and composite core.

    Science.gov (United States)

    Kim, Young-Hoi; Lee, Jong-Hyuk

    2012-02-01

    The influence of the modified process in the fiber-reinforced post and resin core foundation treatment on the fracture resistance and failure pattern of premolar was tested in this study. Thirty-six human mandibular premolars were divided into 4 groups (n = 9). In group DCT, the quartz fibre post (D.T. Light-post) was cemented with resin cement (DUO-LINK) and a core foundation was formed with composite resin (LIGHT-CORE). In group DMO and DMT, resin cement (DUO-LINK) was used for post (D.T. Light-post) cementation and core foundation; in group DMO, these procedures were performed simultaneously in one step, while DMT group was accomplished in separated two steps. In group LCT, the glass fiber post (LuxaPost) cementation and core foundation was accomplished with composite resin (LuxaCore-Dual) in separated procedures. Tooth were prepared with 2 mm ferrule and restored with nickel-chromium crowns. A static loading test was carried out and loads were applied to the buccal surface of the buccal cusp at a 45 degree inclination to the long axis of the tooth until failure occurred. The data were analyzed with MANOVA (α = .05). The failure pattern was observed and classified as either favorable (allowing repair) or unfavorable (not allowing repair). The mean fracture strength was highest in group DCT followed in descending order by groups DMO, DMT, and LCT. However, there were no significant differences in fracture strength between the groups. A higher prevalence of favorable fractures was detected in group DMT but there were no significant differences between the groups. The change of post or core foundation method does not appear to influence the fracture strength and failure patterns.

  20. Fatigue strength of bilayered ceramics under cyclic loading as a function of core veneer thickness ratios.

    Science.gov (United States)

    Dibner, Aurora Clark; Kelly, J Robert

    2016-03-01

    Minimal evidence is available concerning the appropriate thickness of each layer in bilayered ceramic systems. The purpose of this in vitro study was to examine the effect of core-veneer thickness ratios on the fatigue strength of a bonded bilayered ceramic system. Specimens of Ivoclar Porcelain System (IPS) e.max lithium disilicate were fabricated with core/veneer thicknesses of 0.5/1.0 mm, 0.75/0.75 mm, 1.0/0.5 mm, and 1.5/0.0 mm. All specimens were cemented to bases of a dentin-like material. Each specimen was cyclically loaded by a 2-mm-diameter G10 piston in water. Loads ranging from 10 N to the target load were applied at a frequency of 20 Hertz for 500,000 cycles. If cracked, the next specimen was cycled at a lower load; if not cracked, at a higher load (step size of 25 N). Mean and standard deviations of fatigue loads for the different core thicknesses were 0.5-mm core 610.94 N ±130.11; 0.75-mm core 600.0 N ±132.80; 1.0-mm core 537.50 N ±41.67; a Nd 1.5-mm core 501.14 N ±70.12. All veneered groups were significantly stronger than the full thickness group (ANOVA, Pcore groups (χ(2) test, Pcores increases the fatigue strength of the biceramic system. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  1. Stress Distribution on Sandwich Structure with Triangular Grid Cores Suffered from Bending Load

    Directory of Open Access Journals (Sweden)

    Cui Xu

    2015-01-01

    Full Text Available Triangular grid reinforced by carbon fiber/epoxy (CF/EP was designed and manufactured. The sandwich structure was prepared by gluing the core and composite skins. The mechanical properties of the sandwich structure were investigated by the finite element analysis (FEA and three-point bending methods. The calculated bending stiffness and core shear stress were compared to the characteristics of a honeycomb sandwich structure. The results indicated that the triangular core ultimately failed under a bending load of 11000 N; the principal stress concentration was located at the loading region; and the cracks occurred on the interface top skin and triangular core. In addition, the ultimate stress bearing of the sandwich structure was 8828 N. The experimental results showed that the carbon fiber reinforced triangular grid was much stiffer and stronger than the honeycomb structure.

  2. Design of transition cores of RSG GAS (MPR-30) with higher loading silicide fuel

    Energy Technology Data Exchange (ETDEWEB)

    Liem, Peng Hong, E-mail: liemph@nais.ne.j [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, O-okayama, Meguro, Tokyo 152-8550 (Japan); Sembiring, Tagor Malem [Center for Reactor Technology and Nuclear Safety, National Nuclear Energy Agency (Batan), Puspiptek, Serpong, Tangerang 15310 (Indonesia)

    2010-06-15

    A procedure of designing transition cores to achieve the equilibrium silicide core of RSG GAS with higher fuel loading of 300 g U/fuel element (FE) (meat density of 3.55 g U/cm{sup 3}) has been proposed. In the proposed procedure, the EOC excess reactivity of each transition core is minimized in order to satisfy the safety design limit of one-stuck-rod sub-criticality margin while keeping the maximum of radial power peaking factor below the allowable value. Under the design procedure, the initial fuel loadings are increased gradually in two steps, i.e. from 250 to 275 g U/FE followed by 275-300 g U/FE. The analysis results show that all transition cores can satisfy all design requirements and safety limits. We concluded that the obtained transition core design should be adopted into the future core conversion program of RSG GAS. The targeted silicide core can be achieved practically in at least 24 transition cores.

  3. A Methodology for Loading the Advanced Test Reactor Driver Core for Experiment Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cowherd, Wilson M.; Nielsen, Joseph W.; Choe, Dong O.

    2016-11-01

    In support of experiments in the ATR, a new methodology was devised for loading the ATR Driver Core. This methodology will replace the existing methodology used by the INL Neutronic Analysis group to analyze experiments. Studied in this paper was the as-run analysis for ATR Cycle 152B, specifically comparing measured lobe powers and eigenvalue calculations.

  4. Antitumor efficacy of dexamethasone-loaded core-crosslinked polymeric micelles

    NARCIS (Netherlands)

    Coimbra, M.; Rijcken, C.J.; Stigter, M.; Hennink, W.E.; Storm, Gerrit; Schiffelers, R.M.

    2012-01-01

    Abstract In the current study, core-crosslinked polymeric micelles (DEX-PMs) loaded with three different DEX derivatives designed to display different drug release kinetics, were evaluated for cancer therapy and compared to another effective nanomedicine formulation (long-circulating liposomes encap

  5. Experimental study of the mechanical behaviour of pin reinforced foam core sandwich materials under shear load

    Science.gov (United States)

    Dimassi, M. A.; Brauner, C.; Herrmann, A. S.

    2016-03-01

    Sandwich structures with a lightweight closed cell hard foam core have the potential to be used in primary structures of commercial aircrafts. Compared to honeycomb core sandwich, the closed cell foam core sandwich overcomes the issue of moisture take up and makes the manufacturing of low priced and highly integrated structures possible. However, lightweight foam core sandwich materials are prone to failure by localised external loads like low velocity impacts. Invisible cracks could grow in the foam core and threaten the integrity of the structure. In order to enhance the out-of-plane properties of foam core sandwich structures and to improve the damage tolerance (DT) dry fibre bundles are inserted in the foam core. The pins are infused with resin and co-cured with the dry fabric face sheets in an out-of-autoclave process. This study presents the results obtained from shear tests following DIN 53294-standard, on flat sandwich panels. All panels were manufactured with pin-reinforcement manufactured with the Tied Foam Core Technology (TFC) developed by Airbus. The effects of pin material (CFRP and GFRP) and pin volume fraction on the shear properties of the sandwich structure and the crack propagation were investigated and compared to a not pinned reference. It has been concluded that the pin volume fraction has a remarkable effect on the shear properties and damage tolerance of the observed structure. Increasing the pin volume fraction makes the effect of crack redirection more obvious and conserves the integrity of the structure after crack occurrence.

  6. Combined exposure to big endothelin-1 and mechanical loading in bovine sternal cores promotes osteogenesis.

    Science.gov (United States)

    Meyer, Luisa A; Johnson, Michael G; Cullen, Diane M; Vivanco, Juan F; Blank, Robert D; Ploeg, Heidi-Lynn; Smith, Everett L

    2016-04-01

    Increased bone formation resulting from mechanical loading is well documented; however, the interactions of the mechanotransduction pathways are less well understood. Endothelin-1, a ubiquitous autocrine/paracrine signaling molecule promotes osteogenesis in metastatic disease. In the present study, it was hypothesized that exposure to big endothelin-1 (big ET1) and/or mechanical loading would promote osteogenesis in ex vivo trabecular bone cores. In a 2×2 factorial trial of daily mechanical loading (-2000με, 120cycles daily, "jump" waveform) and big ET1 (25ng/mL), 48 bovine sternal trabecular bone cores were maintained in bioreactor chambers for 23days. The bone cores' response to the treatment stimuli was assessed with percent change in core apparent elastic modulus (ΔEapp), static and dynamic histomorphometry, and prostaglandin E2 (PGE2) secretion. Two-way ANOVA with a post hoc Fisher's LSD test found no significant treatment effects on ΔEapp (p=0.25 and 0.51 for load and big ET1, respectively). The ΔEapp in the "no load + big ET1" (CE, 13±12.2%, p=0.56), "load + no big ET1" (LC, 17±3.9%, p=0.14) and "load + big ET1" (LE, 19±4.2%, p=0.13) treatment groups were not statistically different than the control group (CC, 3.3%±8.6%). Mineralizing surface (MS/BS), mineral apposition (MAR) and bone formation rates (BFR/BS) were significantly greater in LE than CC (p=0.037, 0.0040 and 0.019, respectively). While the histological bone formation markers in LC trended to be greater than CC (p=0.055, 0.11 and 0.074, respectively) there was no difference between CE and CC (p=0.61, 0.50 and 0.72, respectively). Cores in LE and LC had more than 50% greater MS/BS (p=0.037, p=0.055 respectively) and MAR (p=0.0040, p=0.11 respectively) than CC. The BFR/BS was more than two times greater in LE (p=0.019) and LC (p=0.074) than CC. The PGE2 levels were elevated at 8days post-osteotomy in all groups and the treatment groups remained elevated compared to the CC group on days 15

  7. How Sorbitan Monostearate Can Increase Drug-Loading Capacity of Lipid-Core Polymeric Nanocapsules.

    Science.gov (United States)

    Poletto, Fernanda S; De Oliveira, Catiúscia P; Wender, Heberton; Regent, Dorothée; Donida, Bruna; Teixeira, Sérgio R; Guterres, Sílvia S; Rossi-Bergmann, Bartira; Pohlmann, Adriana R

    2015-01-01

    Lipid-core polymeric nanocapsules are innovative devices that present distinguished characteristics due to the presence of sorbitan monostearate into the oily-core. This component acted as low-molecular-mass organic gelator for the oil (medium chain triglycerides). The organogel-structured core influenced the polymeric wall characteristics disfavoring the formation of more stable polymer crystallites. This probably occurred due to interpenetration of these pseudo-phases. Sorbitan monostearate dispersed in the oily-core was also able to interact by non-covalent bonding with the drugs increasing the drug loading capacity more than 40 times compared to conventional nanocapsules. We demonstrated that the drug-models quercetin and quercetin pentaacetate stabilized the organogel network probably due to interactions of the drug molecules with the sorbitan monostearate headgroups by hydrogen bonding.

  8. Automatic boiling water reactor loading pattern design using ant colony optimization algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Wang, C.-D. [Department of Engineering and System Science, National Tsing Hua University, 101, Section 2 Kuang Fu Road, Hsinchu 30013, Taiwan (China); Nuclear Engineering Division, Institute of Nuclear Energy Research, No. 1000, Wenhua Rd., Jiaan Village, Longtan Township, Taoyuan County 32546, Taiwan (China)], E-mail: jdwang@iner.gov.tw; Lin Chaung [Department of Engineering and System Science, National Tsing Hua University, 101, Section 2 Kuang Fu Road, Hsinchu 30013, Taiwan (China)

    2009-08-15

    An automatic boiling water reactor (BWR) loading pattern (LP) design methodology was developed using the rank-based ant system (RAS), which is a variant of the ant colony optimization (ACO) algorithm. To reduce design complexity, only the fuel assemblies (FAs) of one eight-core positions were determined using the RAS algorithm, and then the corresponding FAs were loaded into the other parts of the core. Heuristic information was adopted to exclude the selection of the inappropriate FAs which will reduce search space, and thus, the computation time. When the LP was determined, Haling cycle length, beginning of cycle (BOC) shutdown margin (SDM), and Haling end of cycle (EOC) maximum fraction of limit for critical power ratio (MFLCPR) were calculated using SIMULATE-3 code, which were used to evaluate the LP for updating pheromone of RAS. The developed design methodology was demonstrated using FAs of a reference cycle of the BWR6 nuclear power plant. The results show that, the designed LP can be obtained within reasonable computation time, and has a longer cycle length than that of the original design.

  9. Tegafur loading and release properties of magnetite/poly(alkylcyanoacrylate) (core/shell) nanoparticles.

    Science.gov (United States)

    Arias, José L; Ruiz, M Adolfina; Gallardo, Visitación; Delgado, Angel V

    2008-01-01

    In this work, we describe a reproducible method to prepare polymeric colloidal nanospheres of poly(ethyl-2-cyanoacrylate), poly(butylcyanoacrylate), poly(hexylcyanoacrylate) and poly(octylcyanoacrylate) with a magnetite core, and loaded with the anticancer drug Tegafur. The method is based on the emulsion polymerization procedure, often used in the synthesis of poly(alkylcyanoacrylate) nanospheres for drug delivery. The heterogeneous structure of the particles confer them both magnetic-field responsiveness and potential applicability as drug carriers. In order to investigate to what extent is this target achieved, we compare the surface electrical properties of the core/shell particles with those of both the nucleus and the coating material. The hysteresis cycles of both magnetite and composite particles demonstrate that the polymer shell reduces the magnetic responsiveness of the particles, but keeps their soft ferrimagnetic character unchanged. A detailed investigation of the capabilities of the core/shell particles to load this drug is shown. We found, by means of spectrophotometric and electrophoretic measurements, the existence of two drug loading mechanisms: absorption or entrapment in the polymeric network, and surface adsorption. The type of polymer, the pH and the drug concentration are the main factors determining the drug incorporation to the nanoparticles. The release studies showed a biphasic profile affected by the type of polymeric shell, the type of drug incorporation and the amount of drug loaded.

  10. Evolution of anthropoid jaw loading and kinematic patterns.

    Science.gov (United States)

    Ravosa, M J; Vinyard, C J; Gagnon, M; Islam, S A

    2000-08-01

    Major transformations in the skull and masticatory system characterized the evolution of crown anthropoids. To offer further insight into the phylogenetic and arguably adaptive significance of specific primate mandibular loading and kinematic patterns, allometric analyses of metric parameters linked to masticatory function are performed within and between 47 strepsirhine and 45 recent anthropoid species. When possible, basal anthropoids are considered. These results are subsequently integrated with prior experimental and morphological work on primate skull form. As compared to strepsirhines, crown anthropoids have a vertically longer ascending ramus linked to a glenoid and condyle positioned relatively higher above the occlusal plane. Interestingly, anthropoids and strepsirhines do not exhibit different mean ratios of condylar to glenoid height, which suggests that both clades are similar in their ability to evenly distribute occlusal contacts and perhaps forces along the postcanine teeth. Thus, given the considerable suborder differences in the scaling of both glenoid and condylar height, we argue that much of this variation in jaw-joint height is linked to suborder differences in relative facial height due in turn to increased encephalization, basicranial flexion, and facial kyphosis in anthropoids. Due to a more elongate ascending ramus, anthropoids evince more vertically oriented masseters than like-sized strepsirhines. Having a relatively longer ramus and a more medially displaced lateral pterygoid plate, crown anthropoids exhibit medial pterygoids oriented similar to those of strepsirhines, but with a variably longer lever arm. As anthropoid masseters are less advantageously placed to effect transverse movements/forces, we argue that balancing-side deep-masseter activity underlying a wishboning loading regime serves to increase, or at least maintain, transverse levels of jaw movement and occlusal force at the end of the masticatory power stroke. Crown

  11. Estimates of early containment loads from core melt accidents. Draft report for comment

    Energy Technology Data Exchange (ETDEWEB)

    None

    1985-12-01

    The thermal-hydraulic processes and corium debris-material interactions that can result from core melting in a severe accident have been studied to evaluate the potential effect of such phenomena on containment integrity. Pressure and temperature loads associated with representative accident sequences have been estimated for the six various LWR containment types used within the United States. Summaries distilling the analyses are presented and an interpretation of the results provided. 13 refs., 68 figs., 39 tabs.

  12. Perforation of aluminium foam core sandwich panels under impact loading: A numerical and analytical study

    Directory of Open Access Journals (Sweden)

    Elnasri Ibrahim

    2015-01-01

    Full Text Available This paper reports the numerical results of the inversed perforation test instrumented with Split Hopkinson Pressure Bar SHPB with an instrumented pressure bar on the AlSi7Mg0.5 aluminium foam core sandwich panels with 0.8 mm thick 2024 T3 aluminium top and bottom skin. The numerical models are developed in order to understand the origin of the enhancement of the top skin loads found under impact loading (paper published by [1]. Numerical predicted piercing force vs displacement curves are compared with experimental measurements (tests at impact velocities at 27 and 44 m/s. The simulation catches all process of the perforation of the sandwich panels (top skin, foam core, and bottom skin. Within experimental scatter, there is a good agreement between numerical predictions and experimental measurements. Virtual tests with different impact velocities up 200 m/s are presented and showed a significant enhancement of the piercing force under impact loading (top skin peak and foam core plateau loads. In order to understand the origin of these force enhancements, any difference of detailed local information between static and dynamic loading is studied and showed that a shock front effect is responsible for the enhancement piercing force. An analytical model using an improved RPPL shock model based a power law densification assumption is proposed to calculate the top skin piercing force. The improved RPPL shock model agrees with the FE results for small velocities and gives better prediction of the piercing force than the RPPL shock model for large velocities (>100 m/s.

  13. Perforation of aluminium foam core sandwich panels under impact loading: A numerical and analytical study

    Science.gov (United States)

    Elnasri, Ibrahim; Zhao, Han

    2015-09-01

    This paper reports the numerical results of the inversed perforation test instrumented with Split Hopkinson Pressure Bar SHPB with an instrumented pressure bar on the AlSi7Mg0.5 aluminium foam core sandwich panels with 0.8 mm thick 2024 T3 aluminium top and bottom skin. The numerical models are developed in order to understand the origin of the enhancement of the top skin loads found under impact loading (paper published by [1]). Numerical predicted piercing force vs displacement curves are compared with experimental measurements (tests at impact velocities at 27 and 44 m/s). The simulation catches all process of the perforation of the sandwich panels (top skin, foam core, and bottom skin). Within experimental scatter, there is a good agreement between numerical predictions and experimental measurements. Virtual tests with different impact velocities up 200 m/s are presented and showed a significant enhancement of the piercing force under impact loading (top skin peak and foam core plateau loads). In order to understand the origin of these force enhancements, any difference of detailed local information between static and dynamic loading is studied and showed that a shock front effect is responsible for the enhancement piercing force. An analytical model using an improved RPPL shock model based a power law densification assumption is proposed to calculate the top skin piercing force. The improved RPPL shock model agrees with the FE results for small velocities and gives better prediction of the piercing force than the RPPL shock model for large velocities (>100 m/s).

  14. Harmonic Differential Quadrature Analysis of Soft-Core Sandwich Panels under Locally Distributed Loads

    Directory of Open Access Journals (Sweden)

    Xinwei Wang

    2016-11-01

    Full Text Available Sandwich structures are widely used in practice and thus various engineering theories adopting simplifying assumptions are available. However, most engineering theories of beams, plates and shells cannot recover all stresses accurately through their constitutive equations. Therefore, the soft-core is directly modeled by two-dimensional (2D elasticity theory without any pre-assumption on the displacement field. The top and bottom faces act like the elastic supports on the top and bottom edges of the core. The differential equations of the 2D core are then solved by the harmonic differential quadrature method (HDQM. To circumvent the difficulties in dealing with the locally distributed load by point discrete methods such as the HDQM, a general and rigorous way is proposed to treat the locally distributed load. Detailed formulations are provided. The static behavior of sandwich panels under different locally distributed loads is investigated. For verification, results are compared with data obtained by ABAQUS with very fine meshes. A high degree of accuracy on both displacement and stress has been observed.

  15. UV patterned nanoporous solid-liquid core waveguides

    DEFF Research Database (Denmark)

    Gopalakrishnan, Nimi; Sagar, Kaushal Shashikant; Christiansen, Mads Brøkner;

    2010-01-01

    Nanoporous Solid-Liquid core waveguides were prepared by UV induced surface modification of hydrophobic nanoporous polymers. With this method, the index contrast (delta n = 0.20) is a result of selective water infiltration. The waveguide core is defined by UV light, rendering the exposed part...

  16. Fracture Behaviours in Compression-loaded Triangular Corrugated Core Sandwich Panels

    Directory of Open Access Journals (Sweden)

    Zaid N.Z.M.

    2016-01-01

    Full Text Available The failure modes occurring in sandwich panels based on the corrugations of aluminium alloy, carbon fibre-reinforced plastic (CFRP and glass fibre-reinforced plastic (GFRP are analysed in this work. The fracture behaviour of these sandwich panels under compressive stresses is determined through a series of uniform lateral compression performed on samples with different cell wall thicknesses. Compression test on the corrugated-core sandwich panels were conducted using an Instron series 4505 testing machine. The post-failure examinations of the corrugated-core in different cell wall thickness were conducted using optical microscope. Load-displacement graphs of aluminium alloy, GFRP and CFRP specimens were plotted to show progressive damage development with five unit cells. Four modes of failure were described in the results: buckling, hinges, delamination and debonding. Each of these failure modes may dominate under different cell wall thickness or loading condition, and they may act in combination. The results indicate that thicker composites corrugated-core panels tend can recover more stress and retain more stiffness. This analysis provides a valuable insight into the mechanical behaviour of corrugated-core sandwich panels for use in lightweight engineering applications.

  17. Effect of core density on deformation and failure in sandwich composites subjected to underwater impulsive loads

    Directory of Open Access Journals (Sweden)

    S Avachat

    2016-09-01

    Full Text Available The response of sandwich structures to underwater blast loading is analyzed. The analysis focuses on the effect of varying structural attributes on energy dissipation and deformation. The structures analyzed are simply-supported sandwich structures with PVC foam cores and fiber-reinforced polymer composite facesheets. For the analysis carried out, the material properties of the sandwich cores are varied and the total mass is kept constant. In conjunction with experiments, simulations account for underwater blast loading on structures in air-backed and water-backed conditions. Core crushing is accounted for through the Deshpande and Fleck model and facesheet failure is accounted for using the Hashin damage model. Results reveal a significant difference between the response of air-backed and water-backed/submerged structures. In general, thick and low-density cores provide superior blast mitigation and failure resistance. Scaling relations are developed to quantify the responses. These relations can be used to optimize the design of sandwich structures in critical parts of ships like keel, turbine-blades and rudders which involve different contact conditions with water.

  18. Distinct loading conditions reveal various patterns of right ventricular adaptation

    NARCIS (Netherlands)

    Borgdorff, Marinus A. J.; Bartelds, Beatrijs; Dickinson, Michael G.; Steendijk, Paul; de Vroomen, Maartje; Berger, Rolf M. F.

    2013-01-01

    Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct types of RV loading have been associated with different outcomes. To determine whether the adaptive RV response depends o

  19. One-pot synthesis and characterization of rhodamine derivative-loaded magnetic core-shell nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Jin, E-mail: jzhang@eng.uwo.ca; Li Jiaxin [University of Western Ontario, Department of Chemical and Biochemical Engineering (Canada); Razavi, Fereidoon S. [Brock University, Department of Physics (Canada); Mumin, Abdul Md. [University of Western Ontario, Department of Chemical and Biochemical Engineering (Canada)

    2011-05-15

    A new method to produce elaborate nanostructure with magnetic and fluorescent properties in one entity is reported in this article. Magnetite (Fe{sub 3}O{sub 4}) coated with fluorescent silica (SiO{sub 2}) shell was produced through the one-pot reaction, in which one reactor was utilized to realize the synthesis of superparamagnetic core of Fe{sub 3}O{sub 4}, the formation of SiO{sub 2} coating through the condensation and polymerization of tetraethylorthosilicate (TEOS), and the encapsulation of tetramethyl rhodamine isothiocyanate-dextran (TRITC-dextran) within silica shell. Transmission electron microscopy (TEM), energy dispersive X-ray (EDX) analysis, and X-ray diffraction (XRD) were carried out to investigate the core-shell structure. The magnetic core of the core-shell nanoparticles is 60 {+-} 10 nm in diameter. The thickness of the fluorescent SiO{sub 2} shell is estimated at 15 {+-} 5 nm. In addition, the fluorescent signal of the SiO{sub 2} shell has been detected by the laser confocal scanning microscopy (LCSM) with emission wavelength ({lambda}{sub em}) at 566 nm. In addition, the magnetic properties of TRITC-dextran loaded silica-coating iron oxide nanoparticles (Fe{sub 3}O{sub 4}-SiO{sub 2} NPs) were studied. The hysteresis loop of the core-shell NPs measured at room temperature shows that the saturation magnetization (M{sub s}) is not reached even at the field of 70 kOe (7T). Meanwhile, the very low coercivity (H{sub c}) and remanent magnetization (M{sub r}) are 0.375 kOe and 6.6 emu/g, respectively, at room temperature. It indicates that the core-shell particles have the superparamagnetic properties. The measured blocking temperature (T{sub B}) of the TRITC-dextran loaded Fe{sub 3}O{sub 4}-SiO{sub 2} NPs is about 122.5 K. It is expected that the multifunctional core-shell nanoparticles can be used in bio-imaging.

  20. Core-shell poly-methylmethacrylate nanoparticles as effective carriers of electrostatically loaded anionic porphyrin.

    Science.gov (United States)

    Varchi, Greta; Benfenati, Valentina; Pistone, Assunta; Ballestri, Marco; Sotgiu, Giovanna; Guerrini, Andrea; Dambruoso, Paolo; Liscio, Andrea; Ventura, Barbara

    2013-05-01

    Among the medical applications of nanoparticles, their usage as photosensitizer (PS) carriers for photodynamic therapy (PDT) has attracted increasing attention. In the present study we explored the morphological and photophysical properties of core-shell PMMA nanoparticles (PMMA-NPs) electrostatically post-loaded with the synthetic, water soluble 5,10,15,20-tetrakis(4-sulphonatophenyl)-porphyrin (TPPS4). pH response and singlet oxygen analyses of differently loaded samples proved the high capability of the PMMA-NPs to shield the PS from the environment, while retaining the PS singlet oxygen production capability. Preliminary in vitro imaging and phototoxicity experiments on HepG2 cells demonstrated the efficacy of the system to trigger photoinduced cell death in the culture.

  1. Design and characterization of antimicrobial usnic acid loaded-core/shell magnetic nanoparticles.

    Science.gov (United States)

    Taresco, Vincenzo; Francolini, Iolanda; Padella, Franco; Bellusci, Mariangela; Boni, Adriano; Innocenti, Claudia; Martinelli, Andrea; D'Ilario, Lucio; Piozzi, Antonella

    2015-01-01

    The application of magnetic nanoparticles (MNPs) in medicine is considered much promising especially because they can be handled and directed to specific body sites by external magnetic fields. MNPs have been investigated in magnetic resonance imaging, hyperthermia and drug targeting. In this study, properly functionalized core/shell MNPs with antimicrobial properties were developed to be used for the prevention and treatment of medical device-related infections. Particularly, surface-engineered manganese iron oxide MNPs, produced by a micro-emulsion method, were coated with two different polymers and loaded with usnic acid (UA), a dibenzofuran natural extract possessing antimicrobial activity. Between the two polymer coatings, the one based on an intrinsically antimicrobial cationic polyacrylamide (pAcDED) resulted to be able to provide MNPs with proper magnetic properties and basic groups for UA loading. Thanks to the establishment of acid-base interactions, pAcDED-coated MNPs were able to load and release significant drug amounts resulting in good antimicrobial properties versus Staphylococcus epidermidis (MIC = 0.1 mg/mL). The use of pAcDED having intrinsic antimicrobial activity as MNP coating in combination with UA likely contributed to obtain an enhanced antimicrobial effect. The developed drug-loaded MNPs could be injected in the patient soon after device implantation to prevent biofilm formation, or, later, in presence of signs of infection to treat the biofilm grown on the device surfaces.

  2. Analysis and Testing of Load Characteristics for Rotary-Percussive Drilling of Lunar Rock Simulant with a Lunar Regolith Coring Bit

    Directory of Open Access Journals (Sweden)

    Peng Li

    2017-01-01

    Full Text Available Based on an optimized lunar regolith coring bit (LRCB configuration, the load characteristics of rotary-percussive drilling of lunar rock simulant in a laboratory environment are analyzed to determine the effects of the drilling parameters (the rotational velocity, the penetration rate, and the percussion frequency on the drilling load. The process of rotary drilling into lunar rock using an LRCB is modeled as an interaction between an elemental blade and the rock. The rock’s fracture mechanism during different stages of the percussive mechanism is analyzed to create a load forecasting model for the cutting and percussive fracturing of rock using an elemental blade. Finally, a model of the load on the LRCB is obtained from the analytic equation for the bit’s cutting blade distribution; experimental verification of the rotary-impact load characteristics for lunar rock simulant with different parameters is performed. The results show that the penetrations per revolution (PPR are the primary parameter influencing the drilling load. When the PPR are fixed, increasing the percussion frequency reduces the drilling load on the rock. Additionally, the variation pattern of the drilling load of the bit is in agreement with that predicted by the theoretical model. This provides a research basis for subsequent optimization of the drilling procedure and online recognition of the drilling process.

  3. Adaptation of adhesive post and cores to dentin after in vitro occlusal loading: evaluation of post material influence

    OpenAIRE

    Dietschi, Didier; Ardu, Stefano; Rossier-Gerber, Anne; Krejci, Ivo

    2006-01-01

    Fatigue resistance of post and cores is critical to the long term behavior of restored nonvital teeth. The purpose of this in vitro trial was to evaluate the influence of the post material's physical properties on the adaptation of adhesive post and core restorations after cyclic mechanical loading.

  4. Landing pattern and vertical loading rates during first attempt of barefoot running in habitual shod runners.

    Science.gov (United States)

    Cheung, Roy T H; Rainbow, Michael J

    2014-04-01

    There is evidence supporting that habitual barefoot runners are able to disperse impact loading rates by landing pattern modification. Yet, case studies suggested that barefoot running may result in severe running injuries, such as metatarsal and calcaneal stress fractures. Injuries may be due to a difference in biomechanical response between habitual and novice barefoot runners. This study investigated the initial effects of barefoot running in habitual shod runners in terms of landing pattern modification and vertical loading rates. Thirty habitual shod runners (mean age 25.5±5.2years; 18 men; with a minimum running mileage of 30km per week for at least one year) ran on an instrumented treadmill at 10km/h shod and barefoot in a randomized order. Vertical average (VALR) and instantaneous loading rates (VILR) were obtained by established methods. Landing pattern was presented as a ratio between the number of footfalls with a heelstrike and the total step number. Twenty participants demonstrated an automatic transition to a non-heelstrike landing during barefoot running, whereas a mixed landing pattern was observed in 10 participants. Compared to shod running, both VALR and VILR were significantly reduced during barefoot running (pbarefoot running, regardless of the landing pattern. VALR for the non-heelstrike pattern during barefoot running was significantly lower than participants with a mixed landing pattern. Conversely, we observed two participants who completely altered their landing patterns, presented high VALR and VILR values. Habitual shod runners presented lower loading rates during barefoot running but their landing pattern transitions were not uniform. Novice barefoot runners with a mixed landing pattern may sustain higher loading rates, compared with those who completely avoided heelstrike pattern. However, a complete landing pattern modification may not guarantee lower loading rates.

  5. Dithranol-loaded lipid-core nanocapsules improve the photostability and reduce the in vitro irritation potential of this drug

    Energy Technology Data Exchange (ETDEWEB)

    Savian, Ana L. [Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS 97105-900 (Brazil); Rodrigues, Daiane [Curso de Farmácia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS 97105-900 (Brazil); Weber, Julia; Ribeiro, Roseane F. [Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS 97105-900 (Brazil); Motta, Mariana H. [Curso de Farmácia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS 97105-900 (Brazil); Schaffazick, Scheila R.; Adams, Andréa I.H. [Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Santa Maria, Av. Roraima, 1000, Santa Maria, RS 97105-900 (Brazil); Andrade, Diego F. de; Beck, Ruy C.R. [Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, Porto Alegre, RS 90610-000 (Brazil); and others

    2015-01-01

    Dithranol is a very effective drug for the topical treatment of psoriasis. However, it has some adverse effects such as irritation and stain in the skin that make its application and patient adherence to treatment difficult. The aims of this work were to prepare and characterize dithranol-loaded nanocapsules as well as to evaluate the photostability and the irritation potential of these nanocarriers. Lipid-core nanocapsules containing dithranol (0.5 mg/mL) were prepared by interfacial deposition of preformed polymer. EDTA (0.05%) or ascorbic acid (0.02%) was used as antioxidants. After preparation, dithranol-loaded lipid-core nanocapsules showed satisfactory characteristics: drug content close to the theoretical concentration, encapsulation efficiency of about 100%, nanometric mean size (230–250 nm), polydispersity index below 0.25, negative zeta potential, and pH values from 4.3 to 5.6. In the photodegradation study against UVA light, we observed a higher stability of the dithranol-loaded lipid-core nanocapsules comparing to the solution containing the free drug (half-life times around 4 and 1 h for the dithranol-loaded lipid-core nanocapsules and free drug solution containing EDTA, respectively; half-life times around 17 and 7 h for the dithranol-loaded lipid-core nanocapsules and free drug solution containing ascorbic acid, respectively). Irritation test by HET-CAM method was conducted to evaluate the safety of the formulations. From the results it was found that the nanoencapsulation of the drug decreased its toxicity compared to the effects observed for the free drug. - Highlights: • Strategy to prepare lipid-core nanocapsules containing dithranol • Evaluation of the nanoencapsulation effect on the photostability and irritation • Evaluation of the in vitro release of dithranol-loaded lipid-core nanocapsules.

  6. Blast loading of sandwich panels with thin-walled tube cores

    Energy Technology Data Exchange (ETDEWEB)

    Theobold, M.D.; Nurick, G.N. [Cape Town Univ., Cape Town (South Africa). Blast Impact and Survivability Research Unit

    2007-07-01

    This paper presented the results of an experimental and modelling study that investigated the responses to blast loading of a novel sandwich panel used in structural protection. The panel was comprised of thin-walled aluminium alloy square tubes with annealed steel outer plates. A split Hopkinson pressure bar was used to characterize the materials at quasi-static strain rates as well as at high strain rates. A series of blast tests was conducted with explosive charges that ranged from between 13 to 38 g with a blast tube mounted to a ballistic pendulum. Results of the experimental study showed that the panel had a large energy absorption capacity. The tube layout and the choice of materials had a significant influence on panel response. During larger blasts, progressive symmetric buckling was observed in core tubes, and core stability was compromised in lower impulse blasts. It was concluded that finite element analyses conducted on the panels showed good agreement with results obtained during the experimental studies.

  7. Multi-harmonic approach to determine load dependent local flux variations in power transformer cores

    Directory of Open Access Journals (Sweden)

    Riemer Björn

    2015-03-01

    Full Text Available This paper presents a methodology for the calculation of the flux distribution in power transformer cores considering nonlinear material, with reduced computational effort. The calculation is based on a weak coupled multi-harmonic approach. The methodology can be applied to 2D and 3D Finite Element models. The decrease of the computational effort for the proposed approach is >90% compared to a time-stepping method at comparable accuracy. Furthermore, the approach offers a possibility for parallelisation to reduce the overall simulation time. The speed up of the parallelised simulations is nearly linear. The methodology is applied to a single-phase and a three-phase power transformer. Exemplary, the flux distribution for a capacitive load case is determined and the differences in the flux distribution obtained by a 2D and 3D FE model are pointed out. Deviations are significant, due to the fact, that the 2D FE model underestimates the stray fluxes. It is shown, that a 3D FE model of the transformer is required, if the nonlinearity of the core material has to be taken into account.

  8. Core-shell nanocarriers with high paclitaxel loading for passive and active targeting

    Science.gov (United States)

    Jin, Zhu; Lv, Yaqi; Cao, Hui; Yao, Jing; Zhou, Jianping; He, Wei; Yin, Lifang

    2016-06-01

    Rapid blood clearance and premature burst release are inherent drawbacks of conventional nanoparticles, resulting in poor tumor selectivity. iRGD peptide is widely recognized as an efficient cell membrane penetration peptide homing to αVβ3 integrins. Herein, core-shell nanocapsules (NCs) and iRGD-modified NCs (iRGD-NCs) with high drug payload for paclitaxel (PTX) were prepared to enhance the antitumor activities of chemotherapy agents with poor water solubility. Improved in vitro and in vivo tumor targeting and penetration were observed with NCs and iRGD-NCs; the latter exhibited better antitumor activity because iRGD enhanced the accumulation and penetration of NCs in tumors. The NCs were cytocompatible, histocompatible, and non-toxic to other healthy tissues. The endocytosis of NCs was mediated by lipid rafts in an energy-dependent manner, leading to better cytotoxicity of PTX against cancer cells. In contrast with commercial product, PTX-loaded NCs (PTX-NCs) increased area under concentration-time curve (AUC) by about 4-fold, prolonged mean resident time (MRT) by more than 8-fold and reduced the elimination rate constant by greater than 68-fold. In conclusion, the present nanocarriers with high drug-loading capacity represent an efficient tumor-targeting drug delivery system with promising potential for cancer therapy.

  9. Asymmetry-aware load balancing for parallel applications in single-ISA multi-core systems

    Institute of Scientific and Technical Information of China (English)

    EunsungKIM; Hyeonsang EOM; Heon Y. YEOM

    2012-01-01

    Contemporary operating systems for single-ISA (instruction set architecture) multi-core systems attempt to distribute tasks equally among all the CPUs.This approach works relatively well when there is no difference in CPU capability.However,there are cases in which CPU capability differs from one another.For instance,static capability asymmetry results from the advent of new asymmetric hardware,and dynamic capability asymmetry comes from the operating system (OS) outside noise caused from networking or I/O handling.These asymmetries can make it hard for the OS scheduler to evenly distribute the tasks,resulting in less efficient load balancing.In this paper,we propose a user-level load balancer for parallel applications,called the ‘capability balancer',which recognizes the difference of CPU capability and makes subtasks share the entire CPU capability fairly.The balancer can coexist with the existing kernel-level load balancer without detrimenting the behavior of the kernel balancer.The capability balancer can fairly distribute CPU capability to tasks with very little overhead.For real workloads like the NAS Parallel Benchmark (NPB),we have accomplished speedups of up to 9.8% and 8.5% in dynamic and static asymmetries,respectively.We have also experienced speedups of 13.3 % for dynamic asymmetry and 24.1% for static asymmetry in a competitive environment.The impacts of our task selection policies,FIFO (first in,first out) and cache,were compared.The use of the cache policy led to a speedup of 5.3% in overall execution time and a decrease of 4.7% in the overall cache miss count,compared with the FIFO policy,which is used by default.

  10. Technology of load-sensitivity used in the hydraulic system of an all-hydraulic core rig

    Institute of Scientific and Technical Information of China (English)

    XIN De-zhong; CHEN Song-ling; WANG Qing-feng

    2009-01-01

    The existing hydraulic system always have problems of temperature rise, run-ning stability and anti-interference of the implementation components, reliability of hydrau-lic components, maintenance difficulties, and other issues. With high efficiency, energy saving, reliability, easy operating, stable running, anti-interference ability, and other ad-vantages, the load-sensitive hydraulic system is more suitable for coal mine all-hydraulic core rig. Therefore, for the technical development of the coal mine all-hydraulic core rig, the load-sensitive technology employed by the rig should be of great significance.

  11. The muscle activation patterns of lower limb during stair climbing at different backpack load.

    Science.gov (United States)

    Yali, Han; Aiguo, Song; Haitao, Gao; Songqing, Zhu

    2015-01-01

    Stair climbing under backpack load condition is a challenging task. Understanding muscle activation patterns of lower limb during stair climbing with load furthers our understanding of the factors involved in joint pathology and the effects of treatment. At the same time, stair climbing under backpack load requires adjustments of muscle activations and increases joint moment compared to level walking, which with muscle activation patterns are altered as a result of using an assistive technology, such as a wearable exoskeleton leg for human walking power augmentation. Therefore, the aim of this study was to analyze lower limb muscles during stair climbing under different backpack load. Nine healthy volunteers ascended a four-step staircase at different backpack load (0 kg, 10 kg, 20 kg, 30 kg). Electromyographic (EMG) signals were recorded from four lower limb muscles (gastrocnemius, tibialis anterior, hamstring, rectus femoris). The results showed that muscle activation amplitudes of lower limb increase with increasing load during stair climbing, the maximum RMS of gastrocnemius are greater than tibialis anterior, hamstring and rectus femoris whether stair climbing or level walking under the same load condition. However, the maximum RMS of hamstring are smaller than gastrocnemius, tibialis anterior and rectus femoris. The study of muscle activation under different backpack load during stair climbing can be used to design biomechanism and explore intelligent control based on EMG for a wearable exoskeleton leg for human walking power augmentation.

  12. Evaluation of the Start-Up Core Physics Tests at Japan's High Temperature Engineering Test Reactor (Annular Core Loadings)

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess; Nozomu Fujimoto; James W. Sterbentz; Luka Snoj; Atsushi Zukeran

    2010-03-01

    The High Temperature Engineering Test Reactor (HTTR) of the Japan Atomic Energy Agency (JAEA) is a 30 MWth, graphite-moderated, helium-cooled reactor that was constructed with the objectives to establish and upgrade the technological basis for advanced high-temperature gas-cooled reactors (HTGRs) as well as to conduct various irradiation tests for innovative high-temperature research. The core size of the HTTR represents about one-half of that of future HTGRs, and the high excess reactivity of the HTTR, necessary for compensation of temperature, xenon, and burnup effects during power operations, is similar to that of future HTGRs. During the start-up core physics tests of the HTTR, various annular cores were formed to provide experimental data for verification of design codes for future HTGRs. The Japanese government approved construction of the HTTR in the 1989 fiscal year budget; construction began at the Oarai Research and Development Center in March 1991 and was completed May 1996. Fuel loading began July 1, 1998, from the core periphery. The first criticality was attained with an annular core on November 10, 1998 at 14:18, followed by a series of start-up core physics tests until a fully-loaded core was developed on December 16, 1998. Criticality tests were carried out into January 1999. The first full power operation with an average core outlet temperature of 850ºC was completed on December 7, 2001, and operational licensing of the HTTR was approved on March 6, 2002. The HTTR attained high temperature operation at 950 ºC in April 19, 2004. After a series of safety demonstration tests, it will be used as the heat source in a hydrogen production system by 2015. Hot zero-power critical, rise-to-power, irradiation, and safety demonstration testing , have also been performed with the HTTR, representing additional means for computational validation efforts. Power tests were performed in steps from 0 to 30 MW, with various tests performed at each step to confirm

  13. Influences of load pattern selection and higher modes on pushover analysis for R.C. structures

    Institute of Scientific and Technical Information of China (English)

    HOU Shuang; OU Jin-ping

    2008-01-01

    Load pattern selection is one of the critical issues in pushover analysis (POA) when the influence of higher modes is evident. In terms of interstory drift, comparisons between the nonlinear time history analysis (NL-THA) and the pushover analysis (POA) were conducted for three typical RC frame buildings under a va-riety of ground motion levels. Eight typical earthquake inputs, including four earthquake records and four artifi-cial earthquake waves, were employed as the input of NL-THA; five typical lateral load patterns were consid-ered in POA. By means of modal participation factor, the higher mode effect in POA was quantified considering floor numbers and the ground motion intensity. Suggestions about load pattern selection in POA were provided when higher mode influence was found evident.

  14. Spray-dried powders containing tretinoin-loaded engineered lipid-core nanocapsules: development and photostability study.

    Science.gov (United States)

    Marchiori, M C L; Ourique, A F; da Silva, C de B; Raffin, R P; Pohlmann, A R; Guterres, S S; Beck, R C R

    2012-03-01

    The influence of the spray-drying process on the ability of engineered lipid-core nanocapsules to protect tretinoin against UV degradation was evaluated. This approach represents a technological alternative to improve the microbiological stability, storage and transport properties of such formulations. Tretinoin-loaded lipid-core nanocapsules or tretinoin-loaded nanoemulsion were dispersed in lactose (10% w/v) and fed in the spray-drier to obtain a solid product (spray-dried powder containing tretinoin-loaded nanocapsules or nanoemulsion--SD-TTN-NCL or SD-TTN-NE, respectively). SD-TTN-NE showed a lower (p encapsulation (89 +/- 1%) compared to SD-TTN-NCL (94 +/- 2%). Redispersed SD-TTN-NCL and SD-TTN-NE showed z-average sizes of 204 +/- 2 nm and 251 +/- 9 nm, which were close to those of the original suspensions (220 +/- 3 nm and 239 +/- 14 nm, respectively). Similar percentage of photodegradation were determined for tretinoin loaded in nanocapsules (26.15 +/- 4.34%) or in the respective redispersed spray-dried powder (28.73 +/- 6.19 min) after 60 min of UVA radiation exposure (p > 0.05). Our experimental design showed for the first time that spray-dried lipid-core nanocapsules are able to protect tretinoin against UVA radiation, suggesting that the drying process did not alter the supramolecular structure of the lipid-core nanocapsules. Such powders are potential intermediate products for the development of nanomedicines containing tretinoin.

  15. Using an ontology pattern stack to engineer a core ontology of Accounting Information Systems

    NARCIS (Netherlands)

    Blums, Ivar; Weigand, Hans

    Although the field of Accounting Information Systems (AIS) has a long tradition, there is still a lack of a widely adopted conceptualization. In this paper, The UFO ontology patterns are regarded for application by analogy and extension in the engineering of a core ontology for AIS. The new IASB

  16. Using an ontology pattern stack to engineer a core ontology of Accounting Information Systems

    NARCIS (Netherlands)

    Blums, Ivar; Weigand, Hans

    2016-01-01

    Although the field of Accounting Information Systems (AIS) has a long tradition, there is still a lack of a widely adopted conceptualization. In this paper, The UFO ontology patterns are regarded for application by analogy and extension in the engineering of a core ontology for AIS. The new IASB Con

  17. Complex decay patterns in atomic core photoionization disentangled by ion-recoil measurements

    Energy Technology Data Exchange (ETDEWEB)

    Guillemin, Renaud; Bomme, Cedric; Marin, Thierry; Journel, Loic; Marchenko, Tatiana; Kushawaha, Rajesh K.; Piancastelli, Maria Novella; Simon, Marc [Universite Pierre et Marie Curie, Universite Paris 06, Laboratoire de Chimie Physique Matiere et Rayonement, 11 rue Pierre et Marie Curie, FR-75231 Paris Cedex 05 (France); Centre National de la Recherche Scientifique, Laboratoire de Chimie Physique Matiere et Rayonement (UMR7614), 11 rue Pierre et Marie Curie, FR-75231 Paris Cedex 05 (France); Trcera, Nicolas [Synchrotron SOLEIL, l' Orme des Merisiers, Saint-Aubin, BP 48, FR-91192 Gif-sur-Yvette Cedex (France)

    2011-12-15

    Following core 1s ionization and resonant excitation of argon atoms, we measure the recoil energy of the ions due to momentum conservation during the emission of Auger electrons. We show that such ion momentum spectroscopy can be used to disentangle to some degree complex decay patterns, involving both radiative and nonradiative decays.

  18. Non-linear Dynamic Analysis of Steel Hollow I-core Sandwich Panel under Air Blast Loading

    Directory of Open Access Journals (Sweden)

    Asghar Vatani Oskouei

    2015-12-01

    Full Text Available In this paper, the non-linear dynamic response of novel steel sandwich panel with hollow I-core subjected to blast loading was studied. Special emphasis is placed on the evaluation of midpoint displacements and energy dissipation of the models. Several parameters such as boundary conditions, strain rate, mesh dependency and asymmetrical loading are considered in this study. The material and geometric non-linearities are also considered in the numerical simulation. The results obtained are compared with available experimental data to verify the developed FE model. Modeling techniques are described in detail. According to the results, sandwich panels with hollow I-core allowed more plastic deformation and energy dissipation and less midpoint displacement than conventional I-core sandwich panels and also equivalent solid plate with the same weight and material.

  19. Triangular and Fibonacci number patterns driven by stress on core/shell microstructures.

    Science.gov (United States)

    Li, Chaorong; Zhang, Xiaona; Cao, Zexian

    2005-08-05

    Fibonacci number patterns and triangular patterns with intrinsic defects occur frequently on nonplanar surfaces in nature, particularly in plants. By controlling the geometry and the stress upon cooling, these patterns can be reproduced on the surface of microstructures about 10 micrometers in diameter. Spherules of the Ag core/SiOx shell structure, possessing markedly uniform size and shape, self-assembled into the Fibonacci number patterns (5 by 8 and 13 by 21) or the triangular pattern, depending on the geometry of the primary supporting surface. Under proper geometrical constraints, the patterns developed through self-assembly in order to minimize the total strain energy. This demonstrates that highly ordered microstructures can be prepared simultaneously across large areas by stress engineering.

  20. Parameter uncertainty-based pattern identification and optimization for robust decision making on watershed load reduction

    Science.gov (United States)

    Jiang, Qingsong; Su, Han; Liu, Yong; Zou, Rui; Ye, Rui; Guo, Huaicheng

    2017-04-01

    Nutrients loading reduction in watershed is essential for lake restoration from eutrophication. The efficient and optimal decision-making on loading reduction is generally based on water quality modeling and the quantitative identification of nutrient sources at the watershed scale. The modeling process is influenced inevitably by inherent uncertainties, especially by uncertain parameters due to equifinality. Therefore, the emerging question is: if there is parameter uncertainty, how to ensure the robustness of the optimal decisions? Based on simulation-optimization models, an integrated approach of pattern identification and analysis of robustness was proposed in this study that focuses on the impact of parameter uncertainty in water quality modeling. Here the pattern represents the discernable regularity of solutions for load reduction under multiple parameter sets. Pattern identification is achieved by using a hybrid clustering analysis (i.e., Ward-Hierarchical and K-means), which was flexible and efficient in analyzing Lake Bali near the Yangtze River in China. The results demonstrated that urban domestic nutrient load is the most potential source that should be reduced, and there are two patterns for Total Nitrogen (TN) reduction and three patterns for Total Phosphorus (TP) reduction. The patterns indicated different total reduction of nutrient loads, which reflect diverse decision preferences. The robust solution was identified by the highest accomplishment with the water quality at monitoring stations that were improved uniformly with this solution. We conducted a process analysis of robust decision-making that was based on pattern identification and uncertainty, which provides effective support for decision-making with preference under uncertainty.

  1. Development of lycopene-loaded lipid-core nanocapsules: physicochemical characterization and stability study

    Science.gov (United States)

    dos Santos, Priscilla Pereira; Paese, Karina; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin; Costa, Tania Hass; Jablonski, André; Flôres, Simone Hickmann; Rios, Alessandro de Oliveira

    2015-02-01

    The objective of this study was to develop lycopene-loaded lipid-core nanocapsules (Lyc-LNCs) by the interfacial deposition of preformed poly(ɛ-caprolactone) (PCL). Lyc extract (93.9 %) was obtained from tomatoes, and the organic phase was prepared with polymer (PCL), caprylic/capric triglycerides, sorbitan monostearate, and Lyc in a mixture of acetone and ethanol under magnetic stirring at 40 °C. The organic phase was injected into an aqueous phase containing polysorbate 80, and the suspension was concentrated under reduced pressure. The formulation with a Lyc concentration of 85 µg/mL was characterized in terms of size distribution, zeta potential, encapsulation efficiency, pH, viscosity, and color. The Lyc-LNC formulation presented stable values for the z-average (193 ± 4.7 nm) and zeta potential (-11.5 ± 0.40 mV). Despite the lower pH, Lyc content, and color change of the suspension, the nanocapsules showed satisfactory stability, presenting around 50 % Lyc content after 14 days of storage at room temperature (25 °C).

  2. Development of lycopene-loaded lipid-core nanocapsules: physicochemical characterization and stability study

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Priscilla Pereira dos [Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciência e Tecnologia de Alimentos (Brazil); Paese, Karina; Guterres, Silvia Stanisçuaski [Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia (Brazil); Pohlmann, Adriana Raffin [Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Química Orgânica, Instituto de Química (Brazil); Costa, Tania Hass [Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Química, Instituto de Química (Brazil); Jablonski, André [Universidade Federal do Rio Grande do Sul (UFRGS), Departamento de Engenharia de Minas (Brazil); Flôres, Simone Hickmann; Rios, Alessandro de Oliveira, E-mail: alessandro.rios@ufrgs.br [Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciência e Tecnologia de Alimentos (Brazil)

    2015-02-15

    The objective of this study was to develop lycopene-loaded lipid-core nanocapsules (Lyc-LNCs) by the interfacial deposition of preformed poly(ε-caprolactone) (PCL). Lyc extract (93.9 %) was obtained from tomatoes, and the organic phase was prepared with polymer (PCL), caprylic/capric triglycerides, sorbitan monostearate, and Lyc in a mixture of acetone and ethanol under magnetic stirring at 40 °C. The organic phase was injected into an aqueous phase containing polysorbate 80, and the suspension was concentrated under reduced pressure. The formulation with a Lyc concentration of 85 µg/mL was characterized in terms of size distribution, zeta potential, encapsulation efficiency, pH, viscosity, and color. The Lyc-LNC formulation presented stable values for the z-average (193 ± 4.7 nm) and zeta potential (−11.5 ± 0.40 mV). Despite the lower pH, Lyc content, and color change of the suspension, the nanocapsules showed satisfactory stability, presenting around 50 % Lyc content after 14 days of storage at room temperature (25 °C)

  3. Core burnup calculation and accidents analyses of a pressurized water reactor partially loaded with rock-like oxide fuel

    Science.gov (United States)

    Akie, H.; Sugo, Y.; Okawa, R.

    2003-06-01

    A rock-like oxide (ROX) fuel - light water reactor (LWR) burning system has been studied for efficient plutonium transmutation. For the improvement of small negative reactivity coefficients and severe transient behaviors of ROX fueled LWRs, a partial loading core of ROX fuel assemblies with conventional UO 2 assemblies was considered. As a result, although the reactivity coefficients could be improved, the power peaking tends to be large in this heterogeneous core configuration. The reactivity initiated accident (RIA) and loss of coolant accident (LOCA) behaviors were not sufficiently improved. In order to reduce the power peaking, the fuel composition and the assembly design of the ROX fuel were modified. Firstly, erbium burnable poison was added as Er 2O 3 in the ROX fuel to reduce the burnup reactivity swing. Then pin-by-pin Pu enrichment and Er content distributions within the ROX fuel assembly were considered. In addition, the Er content distribution was also considered in the axial direction of the ROX fuel pin. With these modifications, a power peaking factor even lower than the one in a conventional UO 2 fueled core can be obtained. The RIA and LOCA analyses of the modified core have also shown the comparable transient behaviors of ROX partial loading core to those of the UO 2 core.

  4. LIGHT-WEIGHT LOAD-BEARING STRUCTURES REINFORCED BY CORE ELEMENTS MADE OF SEGMENTS AND A METHOD OF CASTING SUCH STRUCTURES

    DEFF Research Database (Denmark)

    2009-01-01

    The invention relates to a light-weight load-bearing structure, reinforced by core elements (2) of a strong material constituting one or more compression or tension zones in the structure to be cast, which core (2) is surrounded by or adjacent to a material of less strength compared to the core (2......), where the core (2) is constructed from segments (1) of core elements (2) assembled by means of one or more prestressing elements (4). The invention further relates to a method of casting of light-weight load-bearing structures, reinforced by core elements (2) of a strong material constituting one...... or more compression or tension zones in the structure to be cast, which core (2) is surrounded by or adjacent to a material of less strength compared to the core (2), where the core (2) is constructed from segments (1) of core elements (2) assembled and hold together by means of one or more prestressing...

  5. LIGHT-WEIGHT LOAD-BEARING STRUCTURES REINFORCED BY CORE ELEMENTS MADE OF SEGMENTS AND A METHOD OF CASTING SUCH STRUCTURES

    DEFF Research Database (Denmark)

    2009-01-01

    The invention relates to a light-weight load-bearing structure, reinforced by core elements (2) of a strong material constituting one or more compression or tension zones in the structure to be cast, which core (2) is surrounded by or adjacent to a material of less strength compared to the core (2...... or more compression or tension zones in the structure to be cast, which core (2) is surrounded by or adjacent to a material of less strength compared to the core (2), where the core (2) is constructed from segments (1) of core elements (2) assembled and hold together by means of one or more prestressing......), where the core (2) is constructed from segments (1) of core elements (2) assembled by means of one or more prestressing elements (4). The invention further relates to a method of casting of light-weight load-bearing structures, reinforced by core elements (2) of a strong material constituting one...

  6. Electromyographic and Neuromuscular Force Patterns Associated with Unexpectedly Loaded Rapid Limb Movements.

    Science.gov (United States)

    Richardson, Charles; Simmons, Roger W.

    Bi-articular, unidirectional arm movements were studied to evaluate the electromyographic (EMG) and neuromuscular force patterns that occur when a limb is unexpectedly perturbed. A series of training trials were continued with a control load spring attached to the apparatus until a pre-specified criterion for learning was attained. The limb was…

  7. Chemotherapy affects the pattern of failure after shear loading of the proximal tibial growth plate.

    NARCIS (Netherlands)

    Leeuwen, B.L.; Hartel, R.M.; Jansen, H.W.B.; Verkerke, G.J.; Veth, R.P.H.; Kamps, W.A.; Hoekstra, H.J.

    2004-01-01

    INTRODUCTION: Tibial bones are shorter and less resistant to shear forces after treatment with doxorubicin, methotrexate, or cisplatin. We investigated the pattern of failure after shear loading of the proximal tibial growth plate in rats treated with these chemotherapeutic agents. MATERIALS AND MET

  8. The influence of impact direction and axial loading on the bone fracture pattern.

    Science.gov (United States)

    Cohen, Haim; Kugel, Chen; May, Hila; Medlej, Bahaa; Stein, Dan; Slon, Viviane; Brosh, Tamar; Hershkovitz, Israel

    2017-08-01

    The effect of the direction of the impact and the presence of axial loading on fracture patterns have not yet been established in experimental 3-point bending studies. To reveal the association between the direction of the force and the fracture pattern, with and without axial loading. A Dynatup Model POE 2000 (Instron Co.) low energy pendulum impact machine was utilized to apply impact loading on fresh pig femoral bones (n=50). The bone clamp shaft was adjusted to position the bone for three-point bending with and without additional bone compression. Four different directions of the force were applied: anterior, posterior, lateral, and medial. The impacted aspect can be distinguished from the non-impacted aspects based on the fracture pattern alone (the most fractured one); the impact point can be identified on bare bones (the area from which all oblique lines radiate and/or the presence of a chip fragment). None of our experiments (with and without compression) yielded a "true" butterfly fracture, but instead, oblique radiating lines emerged from the point of impact (also known as "false" butterfly). Impacts on the lateral and anterior aspects of the bones produce more and longer fracture lines than impacts on the contralateral side; bones subjected to an impact with axial loading are significantly more comminuted and fragmented. Under axial loading, the number of fracture lines is independent of the impact direction. Our study presents an experimental model for fracture analysis and shows that the impact direction and the presence of axial loading during impact significantly affect the fracture pattern obtained. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Influence of regional precipitation patterns on stable isotopes in ice cores from the central Himalayas

    Directory of Open Access Journals (Sweden)

    H. Pang

    2013-05-01

    Full Text Available Several ice cores have been recovered from the Dasuopu Glacier and the East Rongbuk (ER Glacier in the central Himalayas since the 1990s. Although the distance between the ER and the Dasuopu ice core drilling sites is only ∼125 km, the stable isotopic record (δ18O or δD of the ER core is interpreted as a precipitation proxy while the Dasuopu core as a temperature proxy. Thus, the climatological significance of the stable isotopic records of these Himalayan ice cores remains a subject of debate. Based on analysis of regional precipitation patterns over the region, we find that the different interpretations of the Dasuopu and Everest isotopic records may not be contradictive. The north–south and west–east seesaws of the Indian Summer Monsoon (ISM precipitation are primarily responsible for precipitation falling at the ER site, which results in a negative correlation between the ER δ18O or δD record and precipitation amount along the southern slope of the central Himalayas, corresponding to the "amount effect". In addition to the ISM precipitation, non-summer monsoonal precipitation associated with winter westerlies also significantly contributes to precipitation falling at the Dasuopu site, which may cause a positive correlation between the Dasuopu stable isotopic record and temperature, in response to the "temperature effect". Our results have important implications for interpreting the stable isotopic ice core records recovered from different climatological regimes of the Himalayas.

  10. A Numerical Study on the Effect of Facesheet-Core Disbonds on the Buckling Load of Curved Honeycomb Sandwich Panels

    Science.gov (United States)

    Pineda, Evan J.; Myers, David E.; Bednarcyk, Brett A.; Krivanek, Thomas M.

    2015-01-01

    A numerical study on the effect of facesheet-core disbonds on the post-buckling response of curved honeycomb sandwich panels is presented herein. This work was conducted as part of the development of a damage tolerance approach for the next-generation Space Launch System heavy lift vehicle payload fairing. As such, the study utilized full-scale fairing barrel segments as the structure of interest. The panels were composed of carbon fiber reinforced polymer facesheets and aluminum honeycomb core. The panels were analyzed numerically using the finite element method. Facesheet and core nodes in a predetermined circular region were detached to simulate a disbond induced via low-speed impact between the outer mold line facesheet and honeycomb core. Surface-to-surface contact in the disbonded region was invoked to prevent interpenetration of the facesheet and core elements. The diameter of this disbonded region was varied and the effect of the size of the disbond on the post-buckling response was observed. A significant change in the slope of the edge load-deflection response was used to determine the onset of global buckling and corresponding buckling load.

  11. Identification of Synchronous Machine Magnetization Characteristics From Calorimetric Core-Loss and No-Load Curve Measurements

    OpenAIRE

    Rasilo, Paavo; Abdallh, Ahmed Abou-Elyazied; Belahcen, Anouar; Arkkio, Antero; Dupre, Luc

    2015-01-01

    The magnetic material characteristics of a wound-field synchronous machine are identified based on global calorimetric core-loss and no-load curve measurements. This is accomplished by solving a coupled experimental-numerical electromagnetic inverse problem, formulated to minimize the difference between a finite-element (FE) simulation-based Kriging surrogate model and the measurement results. The core-loss estimation in the FE model is based on combining a dynamic iron-loss model and a static v...

  12. Dynamical prediction and pattern mapping in short-term load forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Aguirre, Luis Antonio; Rodrigues, Daniela D.; Lima, Silvio T. [Departamento de Engenharia Eletronica, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, 31270-901 Belo Horizonte, MG (Brazil); Martinez, Carlos Barreira [Departamento de Engenharia Hidraulica e Recursos Hidricos, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, 31270-901 Belo Horizonte, MG (Brazil)

    2008-01-15

    This work will not put forward yet another scheme for short-term load forecasting but rather will provide evidences that may improve our understanding about fundamental issues which underlay load forecasting problems. In particular, load forecasting will be decomposed into two main problems, namely dynamical prediction and pattern mapping. It is argued that whereas the latter is essentially static and becomes nonlinear when weekly features in the data are taken into account, the former might not be deterministic at all. In such cases there is no determinism (serial correlations) in the data apart from the average cycle and the best a model can do is to perform pattern mapping. Moreover, when there is determinism in addition to the average cycle, the underlying dynamics are sometimes linear, in which case there is no need to resort to nonlinear models to perform dynamical prediction. Such conclusions were confirmed using real load data and surrogate data analysis. In a sense, the paper details and organizes some general beliefs found in the literature on load forecasting. This sheds some light on real model-building and forecasting problems and helps understand some apparently conflicting results reported in the literature. (author)

  13. Parametric Study of Flow Patterns behind the Standing Accretion Shock Wave for Core-Collapse Supernovae

    CERN Document Server

    Iwakami, Wakana; Yamada, Shoichi

    2013-01-01

    The systematic research of flow patterns behind the accretion shock wave is conducted using three-dimensional hydrodynamics simulations for core-collapse supernovae in this study. Changing the accretion rate and neutrino luminosity, the steady solutions of the one-dimensional irrotational accretion flow passing through the spherical shock wave are evolved by imposing a random perturbation with 1% amplitude at the onset of the simulations. Depending on the accretion rate and neutrino luminosity, various flow patterns appear behind the shock wave. We classified them into the three fundamental flow patterns: (1) sloshing motion, (2) spiral motion, (3) multiple high-entropy bubbles, and the two anomalous flow patterns: (4) spiral motion with buoyant bubbles, and (5) spiral motion with pulsating rotational velocity. The sloshing and spiral motions tend to be dominant in the higher accretion rate and lower neutrino luminosity, and the generations of multiple buoyant bubbles tend to prevail in the lower accretion ra...

  14. Numerical Analysis of Dynamic Response of Corrugated Core Sandwich Panels Subjected to Near-Field Air Blast Loading

    Directory of Open Access Journals (Sweden)

    Pan Zhang

    2014-01-01

    Full Text Available Three-dimensional fully coupled simulation is conducted to analyze the dynamic response of sandwich panels comprising equal thicknesses face sheets sandwiching a corrugated core when subjected to localized impulse created by the detonation of cylindrical explosive. A large number of computational cases have been calculated to comprehensively investigate the performance of sandwich panels under near-field air blast loading. Results show that the deformation/failure modes of panels depend strongly on stand-off distance. The beneficial FSI effect can be enhanced by decreasing the thickness of front face sheet. The core configuration has a negligible influence on the peak reflected pressure, but it has an effect on the deflection of a panel. It is found that the benefits of a sandwich panel over an equivalent weight solid plate to withstand near-field air blast loading are more evident at lower stand-off distance.

  15. Anti-cancer drug loaded iron-gold core-shell nanoparticles (Fe@Au) for magnetic drug targeting.

    Science.gov (United States)

    Kayal, Sibnath; Ramanujan, Raju Vijayaraghavan

    2010-09-01

    Magnetic drug targeting, using core-shell magnetic carrier particles loaded with anti-cancer drugs, is an emerging and significant method of cancer treatment. Gold shell-iron core nanoparticles (Fe@Au) were synthesized by the reverse micelle method with aqueous reactants, surfactant, co-surfactant and oil phase. XRD, XPS, TEM and magnetic property measurements were utilized to characterize these core-shell nanoparticles. Magnetic measurements showed that the particles were superparamagnetic at room temperature and that the saturation magnetization decreased with increasing gold concentration. The anti-cancer drug doxorubicin (DOX) was loaded onto these Fe@Au nanoparticle carriers and the drug release profiles showed that upto 25% of adsorbed drug was released in 80 h. It was found that the amine (-NH2) group of DOX binds to the gold shell. An in vitro apparatus simulating the human circulatory system was used to determine the retention of these nanoparticle carriers when exposed to an external magnetic field. A high percentage of magnetic carriers could be retained for physiologically relevant flow speeds of fluid. The present findings show that DOX loaded gold coated iron nanoparticles are promising for magnetically targeted drug delivery.

  16. Failure characteristics of a thin metallic sandwich plate with metallic sheared dimple cores under low-velocity impact loading

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Dong Gyu; Jeong, Woo Chul [Chosun University, Gwangju (Korea, Republic of)

    2013-10-15

    The functionality and the performance of a lightweight sandwich plate with periodic cellular metal (PCM) cores are influenced by failure characteristics of the lightweight sandwich plate. The goal of this paper is to investigate the failure characteristics of a thin metallic sandwich plate with metallic sheared dimple cores under low-velocity impact loading through nonlinear finite element analysis. The influence of the imperfection mode of the cores on the impact response of a thin sandwich plate is examined to obtain a proper simulation model. Repeated finite element analyses are performed to examine the failure modes of the sandwich plate for different impact conditions. Normalized impact parameters are defined in order to generalize a dynamic failure map (DFM). DFMs of the thin metallic sandwich plate have been estimated via the regression analysis of critical impact conditions for each failure mode. In addition, the influence of the normalized impact parameters on the failure mode has been investigated using the DFM.

  17. Development of silane grafted ZnO core shell nanoparticles loaded diglycidyl epoxy nanocomposites film for antimicrobial applications.

    Science.gov (United States)

    Suresh, S; Saravanan, P; Jayamoorthy, K; Ananda Kumar, S; Karthikeyan, S

    2016-07-01

    In this article a series of epoxy nanocomposites film were developed using amine functionalized (ZnO-APTES) core shell nanoparticles as the dispersed phase and a commercially available epoxy resin as the matrix phase. The functional group of the samples was characterized using FT-IR spectra. The most prominent peaks of epoxy resin were found in bare epoxy and in all the functionalized ZnO dispersed epoxy nanocomposites (ZnO-APTES-DGEBA). The XRD analysis of all the samples exhibits considerable shift in 2θ, intensity and d-spacing values but the best and optimum concentration is found to be 3% ZnO-APTES core shell nanoparticles loaded epoxy nanocomposites supported by FT-IR results. From TGA measurements, 100wt% residue is obtained in bare ZnO nanoparticles whereas in ZnO core shell nanoparticles grafted DGEBA residue percentages are 37, 41, 45, 46 and 52% for 0, 1, 3, 5 and 7% ZnO-APTES-DGEBA respectively, which is confirmed with ICP-OES analysis. From antimicrobial activity test, it was notable that antimicrobial activity of 7% ZnO-APTES core shell nanoparticles loaded epoxy nanocomposite film has best inhibition zone effect against all pathogens under study.

  18. Effects of pore topology and iron oxide core on doxorubicin loading and release from mesoporous silica nanoparticles

    Science.gov (United States)

    Ronhovde, Cicily J.; Baer, John; Larsen, Sarah C.

    2017-06-01

    Mesoporous silica nanoparticles (MSNs) have a network of pores that give rise to extremely high specific surface areas, making them attractive materials for applications such as adsorption and drug delivery. The pore topology can be readily tuned to achieve a variety of structures such as the hexagonally ordered Mobil Crystalline Material 41 (MCM-41) and the disordered "wormhole" (WO) mesoporous silica (MS) structure. In this work, the effects of pore topology and iron oxide core on doxorubicin loading and release were investigated using MSNs with pore diameters of approximately 3 nm and sub-100 nm particle diameters. The nanoparticles were loaded with doxorubicin, and the drug release into phosphate-buffered saline (PBS, 10 mM, pH 7.4) at 37 °C was monitored by fluorescence spectroscopy. The release profiles were fit using the Peppas model. The results indicated diffusion-controlled release for all samples. Statistically significant differences were observed in the kinetic host-guest parameters for each sample due to the different pore topologies and the inclusion of an iron oxide core. Applying a static magnetic field to the iron oxide core WO-MS shell materials did not have a significant impact on the doxorubicin release. This is the first time that the effects of pore topology and iron oxide core have been isolated from pore diameter and particle size for these materials.

  19. Stress-driven buckling patterns in spheroidal core/shell structures.

    Science.gov (United States)

    Yin, Jie; Cao, Zexian; Li, Chaorong; Sheinman, Izhak; Chen, Xi

    2008-12-09

    Many natural fruits and vegetables adopt an approximately spheroidal shape and are characterized by their distinct undulating topologies. We demonstrate that various global pattern features can be reproduced by anisotropic stress-driven buckles on spheroidal core/shell systems, which implies that the relevant mechanical forces might provide a template underpinning the topological conformation in some fruits and plants. Three dimensionless parameters, the ratio of effective size/thickness, the ratio of equatorial/polar radii, and the ratio of core/shell moduli, primarily govern the initiation and formation of the patterns. A distinct morphological feature occurs only when these parameters fall within certain ranges: In a prolate spheroid, reticular buckles take over longitudinal ridged patterns when one or more parameters become large. Our results demonstrate that some universal features of fruit/vegetable patterns (e.g., those observed in Korean melons, silk gourds, ribbed pumpkins, striped cavern tomatoes, and cantaloupes, etc.) may be related to the spontaneous buckling from mechanical perspectives, although the more complex biological or biochemical processes are involved at deep levels.

  20. A Simplified Short Term Load Forecasting Method Based on Sequential Patterns

    DEFF Research Database (Denmark)

    Kouzelis, Konstantinos; Bak-Jensen, Birgitte; Mahat, Pukar

    2014-01-01

    , require considerable expertise for model construction and re-construction. Consequently, they might be impractical to use in case multiple regional forecasts are to be conducted. In this perspective, a simplified hour-ahead load forecasting algorithm was created so as to provide an automated approach...... to the problem as an alternative to other established forecasting techniques. This algorithm is based on sequential patterns and, hence, the continuous data are discretized in order to compare recent to past patterns. Although some error due to discretization is introduced, the method performs adequately well...... in comparison with an ARIMA model....

  1. Load Distribution Patterns for Displacement-based Seismic Design of RC Framed Buildings

    Science.gov (United States)

    Varughese, Jiji Anna; Menon, Devdas; Meher Prasad, A.

    2014-12-01

    The behaviour of tall frames is characterized by the influence of higher modes in addition to the fundamental mode and thus the design procedures for Displacement-based Design (DBD) adopt several measures to control higher mode effects. The performances of 4, 9 and 15-storeyed frames, designed by DBD were verified using non-linear time history analyses. Higher values of inter-storey drift and damage index were seen near the top of tall frames, which shows the inefficiency of the design method in accounting for higher mode effect. As the principle of damage-limiting aseismic design is to get uniform damage along the height of the frame, several load distribution patterns were examined and the storey shear distributions were compared to identify the best pattern to get uniform damage. The Chao load distribution was found to give higher storey shear at top and thus the frames were redesigned using this load distribution. The efficiency of Chao load distribution in reducing higher mode effects is demonstrated using non-linear time history analyses.

  2. Advanced and flexible genetic algorithms for BWR fuel loading pattern optimization

    Energy Technology Data Exchange (ETDEWEB)

    Martin-del-Campo, Cecilia [Departamento de Sistemas Energeticos, Facultad de Ingenieria, Universidad Nacional Autonoma de Mexico, Paseo Cuauhnahuac 8532, Jiutepec, Mor., 62550 (Mexico)], E-mail: cmcm@fi-b.unam.mx; Palomera-Perez, Miguel-Angel [Instituto de Investigaciones en Matematicas Aplicadas y Sistemas, Universidad Nacional Autonoma de Mexico, Circuito Escolar, Ciudad Universitaria, 04510 DF (Mexico)], E-mail: mapp@uxmcc2.iimas.unam.mx; Francois, Juan-Luis [Departamento de Sistemas Energeticos, Facultad de Ingenieria, Universidad Nacional Autonoma de Mexico, Paseo Cuauhnahuac 8532, Jiutepec, Mor., 62550 (Mexico)], E-mail: jlfl@fi-b.unam.mx

    2009-10-15

    This work proposes advances in the implementation of a flexible genetic algorithm (GA) for fuel loading pattern optimization for Boiling Water Reactors (BWRs). In order to avoid specific implementations of genetic operators and to obtain a more flexible treatment, a binary representation of the solution was implemented; this representation had to take into account that a little change in the genotype must correspond to a little change in the phenotype. An identifier number is assigned to each assembly by means of a Gray Code of 7 bits and the solution (the loading pattern) is represented by a binary chain of 777 bits of length. Another important contribution is the use of a Fitness Function which includes a Heuristic Function and an Objective Function. The Heuristic Function which is defined to give flexibility on the application of a set of positioning rules based on knowledge, and the Objective Function that contains all the parameters which qualify the neutronic and thermal hydraulic performances of each loading pattern. Experimental results illustrating the effectiveness and flexibility of this optimization algorithm are presented and discussed.

  3. Dexamethasone loaded core-shell SF/PEO nanofibers via green electrospinning reduced endothelial cells inflammatory damage.

    Science.gov (United States)

    Chen, Weiming; Li, Dawei; Ei-Shanshory, Ahmed; El-Newehy, Mohamed; Ei-Hamshary, Hany A; Al-Deyab, Salem S; He, Chuanglong; Mo, Xiumei

    2015-02-01

    Silk fibroin (SF)/PEO nanofibers prepared by green electrospinning is safe, non-toxic and environment friendly, it is a potential drug delivery carrier for tissue engineering. In this study, a core-shell nanofibers named as Dex@SF/PEO were obtained by green electrospinning with SF/PEO as the shell and dexamethasone (Dex) in the core. The nanofiber morphology and core-shell structure were studied by Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM). The Dex release behavior from the nanofibers was tested by High Performance liquid (HPLC) method. The protective effect of drug loaded nanofibers mats on Porcine hip artery endothelial cells (PIECs) against LPS-induced inflammatory damage were determined by MTT assay. TEM result showed the distinct core-shell structure of nanofibers. In vitro drug release studies demonstrated that dexamethasone can sustain release over 192 h and core-shell nanofibers showed more slow release of Dex compared with the blending electrospinning nanofibers. Anti-inflammatory activity in vitro showed that released Dex can reduce the PIECs inflammatory damage and apoptosis which induced by lipopolysaccharide (LPS). Dex@SF/PEO nanofibers are safe and non-toxic because of no harmful organic solvents used in the preparation, it is a promising environment friendly drug carrier for tissue engineering.

  4. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  5. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  6. Synergistic Effect of Cold Atmospheric Plasma and Drug Loaded Core-shell Nanoparticles on Inhibiting Breast Cancer Cell Growth.

    Science.gov (United States)

    Zhu, Wei; Lee, Se-Jun; Castro, Nathan J; Yan, Dayun; Keidar, Michael; Zhang, Lijie Grace

    2016-01-01

    Nano-based drug delivery devices allowing for effective and sustained targeted delivery of therapeutic agents to solid tumors have revolutionized cancer treatment. As an emerging biomedical technique, cold atmospheric plasma (CAP), an ionized non-thermal gas mixture composed of various reactive oxygen species, reactive nitrogen species, and UV photons, shows great potential for cancer treatment. Here we seek to develop a new dual cancer therapeutic method by integrating promising CAP and novel drug loaded core-shell nanoparticles and evaluate its underlying mechanism for targeted breast cancer treatment. For this purpose, core-shell nanoparticles were synthesized via co-axial electrospraying. Biocompatible poly (lactic-co-glycolic acid) was selected as the polymer shell to encapsulate anti-cancer therapeutics. Results demonstrated uniform size distribution and high drug encapsulation efficacy of the electrosprayed nanoparticles. Cell studies demonstrated the effectiveness of drug loaded nanoparticles and CAP for synergistic inhibition of breast cancer cell growth when compared to each treatment separately. Importantly, we found CAP induced down-regulation of metastasis related gene expression (VEGF, MTDH, MMP9, and MMP2) as well as facilitated drug loaded nanoparticle uptake which may aid in minimizing drug resistance-a major problem in chemotherapy. Thus, the integration of CAP and drug encapsulated nanoparticles provides a promising tool for the development of a new cancer treatment strategy.

  7. Impact of Thresholds and Load Patterns when Executing HPC Applications with Cloud Elasticity

    Directory of Open Access Journals (Sweden)

    Vinicius Facco Rodrigues

    2016-04-01

    Full Text Available Elasticity is one of the most known capabilities related to cloud computing, being largely deployed reactively using thresholds. In this way, maximum and minimum limits are used to drive resource allocation and deallocation actions, leading to the following problem statements: How can cloud users set the threshold values to enable elasticity in their cloud applications? And what is the impact of the application’s load pattern in the elasticity? This article tries to answer these questions for iterative high performance computing applications, showing the impact of both thresholds and load patterns on application performance and resource consumption. To accomplish this, we developed a reactive and PaaS-based elasticity model called AutoElastic and employed it over a private cloud to execute a numerical integration application. Here, we are presenting an analysis of best practices and possible optimizations regarding the elasticity and HPC pair. Considering the results, we observed that the maximum threshold influences the application time more than the minimum one. We concluded that threshold values close to 100% of CPU load are directly related to a weaker reactivity, postponing resource reconfiguration when its activation in advance could be pertinent for reducing the application runtime.

  8. Protein-loaded microspheres prepared by sequential adsorption of dextran sulphate and protamine on melamine formaldehyde core.

    Science.gov (United States)

    Balabushevich, Nadezda G; Larionova, Natalia I

    2009-11-01

    Polyelectrolyte multilayer microspheres were fabricated by layer-by-layer self-assembly of a dextran sulphate and a protamine on melamine formaldehyde cores, followed by the partial decomposition of the core. Effects of pH on the encapsulation of proteins and enzymes with different physico-chemical properties (insulin, aprotinin, peroxidase, glucose oxidase (GOD), catalase (Cat)) in the prepared microspheres were then studied. This method of protein encapsulation demonstrated a high loading capacity and efficiency. The protein incorporation and release was regulated by the pH of the solution. Encapsulated enzymes retained a high specific activity depending on the amount of protein incorporated. Bienzyme system GOD/Cat immobilized in the microspheres was suitable for the glucose content assay.

  9. Loading Patterns of the Posterior Cruciate Ligament in the Healthy Knee: A Systematic Review

    Science.gov (United States)

    List, Renate; Oberhofer, Katja; Fucentese, Sandro F.; Snedeker, Jess G.; Taylor, William R.

    2016-01-01

    Background The posterior cruciate ligament (PCL) is the strongest ligament of the knee, serving as one of the major passive stabilizers of the tibio-femoral joint. However, despite a number of experimental and modelling approaches to understand the kinematics and kinetics of the ligament, the normal loading conditions of the PCL and its functional bundles are still controversially discussed. Objectives This study aimed to generate science-based evidence for understanding the functional loading of the PCL, including the anterolateral and posteromedial bundles, in the healthy knee joint through systematic review and statistical analysis of the literature. Data sources MEDLINE, EMBASE and CENTRAL Eligibility criteria for selecting studies Databases were searched for articles containing any numerical strain or force data on the healthy PCL and its functional bundles. Studied activities were as follows: passive flexion, flexion under 100N and 134N posterior tibial load, walking, stair ascent and descent, body-weight squatting and forward lunge. Method Statistical analysis was performed on the reported load data, which was weighted according to the number of knees tested to extract average strain and force trends of the PCL and identify deviations from the norms. Results From the 3577 articles retrieved by the initial electronic search, only 66 met all inclusion criteria. The results obtained by aggregating data reported in the eligible studies indicate that the loading patterns of the PCL vary with activity type, knee flexion angle, but importantly also the technique used for assessment. Moreover, different fibres of the PCL exhibit different strain patterns during knee flexion, with higher strain magnitudes reported in the anterolateral bundle. While during passive flexion the posteromedial bundle is either lax or very slightly elongated, it experiences higher strain levels during forward lunge and has a synergetic relationship with the anterolateral bundle. The strain

  10. Detecting The Liquid Core In Continuous Casting Slabs By Load Torque Estimation In Unbending Zone

    Directory of Open Access Journals (Sweden)

    Emil CEANGA

    2002-12-01

    Full Text Available The development in continuous casting process has been strongly dominated by the demands of quality improvement and reduced costs for steel products in recent years. To achieve these goals consideration has been given by increasing the velocity of casting process. In that case a portion of a cross section of the slab are still licked in the unbending zone. Information about the deformation, stress and strain in solid shells is quit important in terms of the cost quality. These information are obtained by load torque estimation using the electrical quantities of the drive system for the unbending zone. A sensor less drive system with induction motor is considerate. The electrical drive systems are controlled in torque and speed. The measurements of voltage and current components and the imposed speed are the inputs for the real time load torque estimator. The estimated load torque is compared with the calculated maximal load torque for the entirely solidified slab state. From this comparison results the thickens of the slab licked zone.

  11. Detection of load application onto an optical fiber through changes in speckle patterns in an output light spot

    Science.gov (United States)

    Hasegawa, Makoto; Takeda, Ryo; Fujioka, Yuki

    2016-10-01

    For the purpose of investigating possibilities of utilizing, for sensing application, changes in speckle patterns to be observed in an output light spot from an optical fiber due to external disturbance, a certain level of load was applied onto an optical fiber through which laser beams emitted from a laser diode were propagating, and changes in the speckle patterns in the output light spot were investigated. In order to realize effective load application onto the optical fiber, a load application section was provided in which several ridges were intentionally provided onto opposite flat plates. A jacket-covered communication-grade multi-mode glass optical fiber was placed in the load application section so that corrugated bending of the fiber was intentionally induced via load application due to the ridges. A PV cell panel was irradiated with the output light spot from the optical fiber containing the speckle patterns therein. When weights were placed in the load application section, an output voltage from the PV cell panel was changed, indicating that the load application onto the optical fiber can be detected with this detection setup. Removal of the once-placed weights was also detected via changes in the PV cell panel output. Then, the load application onto the optical fiber and its removal was successfully detected via turn-on/off operations of an LED which was controlled in accordance with the changes in the output voltage level from the PV cell panel, in other words, through the changes in the speckle patterns.

  12. Characterization of rheology and release profiles of olanzapine-loaded lipid-core nanocapsules in thermosensitive hydrogel.

    Science.gov (United States)

    Dimer, F A; Pohlmann, A R; Guterres, S S

    2013-12-01

    In this study we developed a new drug delivery system for olanzanpine comprised of drug-loaded lipid-core nanocapsules incorporated in a thermosensitive hydrogel, intended to sustain the drug release. Firstly, olanzapine, a hydrophobic drug, was loaded in poly(epsilon-caprolactone) lipid core nanocapsules prepared by interfacial deposition of preformed polymer. The effects of the presence of ethanol and the amounts of sorbitan monostearate and medium-chain triglycerides on the particle size, zeta potential, polydispersity index, presence of microparticles and encapsulation efficiency were investigated using a 2(3) factorial design. The optimized nanocapsules were incorporated into a hydrophilic polymer (Poloxamer 407) dispersion in order to obtain a thermosensitive gel. The formulation containing 0.077 g of sorbitan monostearate, 0.22 ml of medium-chain triglycerides, 3 ml of ethanol and 18% of the thermosensitive polymer was selected according to the physicochemical properties. The rheology and release profiles of the mixed hydrophobic and hydrophilic delivery system were successfully characterized and revealed its great potential for the administration of hydrophobic drugs such as olanzapine with sustained in situ drug release.

  13. Investigation of cutaneous penetration properties of stearic acid loaded to dendritic core-multi-shell (CMS) nanocarriers.

    Science.gov (United States)

    Lohan, S B; Icken, N; Teutloff, C; Saeidpour, S; Bittl, R; Lademann, J; Fleige, E; Haag, R; Haag, S F; Meinke, M C

    2016-03-30

    Dendritic core-multi shell (CMS) particles are polymer based systems consisting of a dendritic polar polyglycerol polymer core surrounded by a two-layer shell of nonpolar C18 alkyl chains and hydrophilic polyethylene glycol. Belonging to nanotransport systems (NTS) they allow the transport and storage of molecules with different chemical characters. Their amphipihilic character CMS-NTS permits good solubility in aqueous and organic solutions. We showed by multifrequency electron paramagnetic resonance (EPR) spectroscopy that spin-labeled 5-doxyl stearic acid (5DSA) can be loaded into the CMS-NTS. Furthermore, the release of 5DSA from the carrier into the stratum corneum of porcine skin was monitored ex vivo by EPR spectroscopy. Additionally, the penetration of the CMS-NTS into the skin was analyzed by fluorescence microscopy using indocarbocyanine (ICC) covalently bound to the nanocarrier. Thereby, no transport into the viable skin was observed, whereas the CMS-NTS had penetrated into the hair follicles down to a depth of 340 μm ± 82 μm. Thus, it could be shown that the combined application of fluorescence microscopy and multi-frequency EPR spectroscopy can be an efficient tool for investigating the loading of spin labeled drugs to nanocarrier systems, drug release and penetration into the skin as well as the localization of the NTS in the skin. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Core-shell meso/microporous carbon host for sulfur loading toward applications in lithium-sulfur batteries

    Institute of Scientific and Technical Information of China (English)

    Juan Zhang; Huan Ye; Yaxia Yin; Yuguo Guo

    2014-01-01

    Lithium-sulfur (Li-S) batteries belong to one of the promising technologies for high-energy-density rechargeable batteries. However, sulfur cathodes suffer from inherent problems of its poor electronic conductivity and the shuttling of highly dissoluble lithium polysulfides generated during the cycles. Loading sulfur into porous carbons has been proved to be an effective approach to alleviate these issues. Mesoporous and microporous carbons have been widely used for sulfur accommodation, but mesoporous carbons have poor sulfur confinement, whereas microporous carbons are impeded by low sulfur loading rates. Here, a core-shell carbon, combining both the merits of mesoporous carbon with large pore volume and microporous carbon with effective sulfur confinement, was prepared by coating the mesoporous CMK-3 with a microporous carbon (MPC) shell and served as the carbon host (CMK-3@MPC) to accommodate sulfur. After sulfur infusion, the as-obtained S/(CMK-3@MPC) cathode delivered a high initial capacity of up to 1422 mAh·g-1 and sustained 654 mAh·g-1 reversible specific capacity after 36 cycles at 0.1 C. The good performance is ascribed to the unique core-shell structure of the CMK-3@MPC matrix, in which sulfur can be effectively confined within the meso/microporous carbon host, thus achieving simultaneously high electrochemical utilization.

  15. The effect of motion patterns on edge-loading of metal-on-metal hip resurfacing.

    Science.gov (United States)

    Mellon, S J; Kwon, Y-M; Glyn-Jones, S; Murray, D W; Gill, H S

    2011-12-01

    The occurrence of pseudotumours (soft tissue masses relating to the hip joint) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) has been associated with high serum metal ion levels and consequently higher than normal bearing wear. We investigated the relationship between serum metal ion levels and contact stress on the acetabular component of MoMHRA patients for two functional activities; gait and stair descent. Four subjects with MoMHRA, who had their serum metal ion levels measured, underwent motion analysis followed by CT scanning. Their motion capture data was combined with published hip contact forces and finite element models representing 14% (peak force) and 60% (end of stance) of the gait cycle and 52% (peak force) of stair descent activity were created. The inclination angle of the acetabular component was increased by 10° in 1° intervals and the contact stresses were determined at each interval for each subject. When the inclination angle was altered in such a way as to cause the hip contact force to pass through the edge of the acetabular component edge-loading occurred. Edge-loading increased the contact stress by at least 50%; the maximum increase was 108%. Patients with low serum metal ion levels showed no increase in contact stress at peak force during gait or stair descent. Patients with high serum metal ion levels exhibited edge-loading with an increase to the inclination angle of their acetabular components. The increase in inclination angle that induced edge-loading for these subjects was less than the inter-subject variability in the angle of published hip contact forces. The results of this study suggest that high serum metal ion levels are the result of inclination angle influenced edge-loading but that edge-loading cannot be attributed to inclination angle alone and that an individual's activity patterns can reduce or even override the influence of a steep acetabular component and prevent edge-loading. Copyright © 2011 IPEM

  16. Reflector modelization in neutronic and optimization methods applied to fuel loading pattern; Modelisation du reflecteur en neutronique et methodes d`optimisation appliquees aux plans de rechargement

    Energy Technology Data Exchange (ETDEWEB)

    Argaud, J.P.

    1995-12-01

    I Physical description of P.W.R nuclear core can be handled by multigroup neutronic diffusion model. We are interested in two problems, using the same approach for the optimization aspect. To deal with some differences between calculations and measurements, the question of their reduction is then introduced. A reflector parameters identification from core measurements is then purposed, the reflector being at the present time the less known part of core diffusion model. This approach conducts to study the reflector model, in particular by an analysis of its transport origin. It leads finally to a new model of reflector described by boundary operators using an integral formulation on the core/reflector interface. That is on this new model that a parameter identification formulation of calculations-measurements differences reduction is given, using an adjoint state formulation to minimize errors by a gradient method. Furthermore, nuclear fuel reload of P.W.R core needs an optimal distribution of fuel assemblies, namely a loading pattern. This combinatorial optimization problem is then expressed as a cost function minimization, the cost function describing the power spatial distribution. Various methods (linear programming, simulated annealing,...), used to solve this problem, are detailed, given in particular a practical search example. A new approach is then proposed, using the gradient of the cost function to direct the search in the patterns discrete space. Final results of complete patterns search trials are presented, and compared to those obtained by other methods. In particular the results are obtained very quickly. (author). 81 refs., 55 figs., 5 appends.

  17. Sustained antioxidant activity of quercetin-loaded lipid-core nanocapsules.

    Science.gov (United States)

    Weiss-Angeli, Valéria; Poletto, Fernanda S; de Marco, Samuel L; Salvador, Miriam; da Silveira, Nádya P; Guterres, Sílvia S; Pohlmann, Adriana R

    2012-03-01

    Lipid-core nanocapsules (LNC) are vesicular nanocarriers prepared by solvent displacement. LNC have been previously prepared using medium-chain triglyceride and sorbitan monostearate as liquid and solid lipophilic components dispersed in the core, surrounded by poly(epsilon-caprolactone) (PCL). Our objective was to investigate the antioxidant activity of LNC containing quercetin (QUE), a radical scavenger, prepared with octyl methoxycinnamate and sorbitan monostearate as lipophilic core components and PCL as the polymer wall. We selected Saccharomyces cerevisae cells as the proposed biological model. QUE-LNC presented z-average diameter of 212 nm, pH of 5.51 and zeta potential of -11 mV. Multiple light scattering analysis (TurbiscanLab) showed a photon path length of 172 microm. Furthermore, a validated turbidimetric study determined that the density of particles in suspension was 1.66 x 10(13). DSC analysis showed that the melting temperature of PCL shifted to lower values when in contact with octyl methoxycinnamate indicating a molecular interaction. After 1 h (7 h), the QUE-LNC formulation and QUE solution incubated with H2O2 showed cell survival of 84.4% (87.7%) and 65.6% (7.3%), respectively. After 35 h of incubation, cell survival was 31.7% and 0.9%, respectively. The QUE-LNC showed sustained antioxidant activity and potential as a nanostructured material to formulate final products.

  18. Study of power load pattern on EAST divertor using PFCFlux code

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Bin, E-mail: binzhang@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Firdaouss, Mehdi [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France); Gong, Xianzu [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Ekedahl, Annika [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France); Peng, Xuebing [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Zhang, Xiaodong, E-mail: xdzhang@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2016-06-15

    Highlights: • This paper demonstrates the modeling result of power load pattern on EAST graphite divertor by using the PFCFlux code. • The grazing angle varies both poloidally and toroidally, changing by half a degree over the distance of 50 mm away from the strike point. • The correlation between both grazing angle and flux expansion and the magnetic equilibrium parameters are found by using the linear regression method. • The modeling result indicates that the edges of graphite tiles of EAST divertor are perfectly shadowed. - Abstract: The power load pattern on an EAST divertor component, spanning six tiles in the poloidal direction, has been studied with the PFCFlux code. A total of 49 different EAST plasma equilibria in lower single null configuration are used in the study. It is found that the incidence angle, or grazing angle, varies both toroidally and poloidally on the target, changing by approximately half a degree over a distance of 50 mm from the strike point. Strong correlations between the triangularity of the magnetic equilibrium and both the grazing angle and the flux expansion are found by using linear regression. A smaller value of triangularity gives wider plasma-wetted region on the target in lower-outer configuration, and a narrower plasma-wetted region in lower-inner configuration.

  19. Attentional load modulates large-scale functional brain connectivity beyond the core attention networks.

    Science.gov (United States)

    Alnæs, Dag; Kaufmann, Tobias; Richard, Geneviève; Duff, Eugene P; Sneve, Markus H; Endestad, Tor; Nordvik, Jan Egil; Andreassen, Ole A; Smith, Stephen M; Westlye, Lars T

    2015-04-01

    In line with the notion of a continuously active and dynamic brain, functional networks identified during rest correspond with those revealed by task-fMRI. Characterizing the dynamic cross-talk between these network nodes is key to understanding the successful implementation of effortful cognitive processing in healthy individuals and its breakdown in a variety of conditions involving aberrant brain biology and cognitive dysfunction. We employed advanced network modeling on fMRI data collected during a task involving sustained attentive tracking of objects at two load levels and during rest. Using multivariate techniques, we demonstrate that attentional load levels can be significantly discriminated, and from a resting-state condition, the accuracy approaches 100%, by means of estimates of between-node functional connectivity. Several network edges were modulated during task engagement: The dorsal attention network increased connectivity with a visual node, while decreasing connectivity with motor and sensory nodes. Also, we observed a decoupling between left and right hemisphere dorsal visual streams. These results support the notion of dynamic network reconfigurations based on attentional effort. No simple correspondence between node signal amplitude change and node connectivity modulations was found, thus network modeling provides novel information beyond what is revealed by conventional task-fMRI analysis. The current decoding of attentional states confirms that edge connectivity contains highly predictive information about the mental state of the individual, and the approach shows promise for the utilization in clinical contexts.

  20. Changes in running pattern due to fatigue and cognitive load in orienteering.

    Science.gov (United States)

    Millet, Guillaume Y; Divert, Caroline; Banizette, Marion; Morin, Jean-Benoit

    2010-01-01

    The aim of this study was to examine the influence of fatigue on running biomechanics in normal running, in normal running with a cognitive task, and in running while map reading. Nineteen international and less experienced orienteers performed a fatiguing running exercise of duration and intensity similar to a classic distance orienteering race on an instrumented treadmill while performing mental arithmetic, an orienteering simulation, and control running at regular intervals. Two-way repeated-measures analysis of variance did not reveal any significant difference between mental arithmetic and control running for any of the kinematic and kinetic parameters analysed eight times over the fatiguing protocol. However, these parameters were systematically different between the orienteering simulation and the other two conditions (mental arithmetic and control running). The adaptations in orienteering simulation running were significantly more pronounced in the elite group when step frequency, peak vertical ground reaction force, vertical stiffness, and maximal downward displacement of the centre of mass during contact were considered. The effects of fatigue on running biomechanics depended on whether the orienteers read their map or ran normally. It is concluded that adding a cognitive load does not modify running patterns. Therefore, all changes in running pattern observed during the orienteering simulation, particularly in elite orienteers, are the result of adaptations to enable efficient map reading and/or potentially prevent injuries. Finally, running patterns are not affected to the same extent by fatigue when a map reading task is added.

  1. LC-MS/MS method applied to preclinical pharmacokinetic investigation of olanzapine-loaded lipid-core nanocapsules

    Directory of Open Access Journals (Sweden)

    Frantiescoli A. Dimer

    2014-01-01

    Full Text Available In spite of different methods reported in the literature to determine olanzapine in biological fluids, all of them used high volumes of plasma. Therefore, the purpose of this paper was to develop an LC-MS/MS method using small plasma volume (0.1 mL to apply in a preclinical pharmacokinetic investigation. The method was linear over the concentration ranges of 10 - 1000 ng mL-1. Extraction recoveries, stability, and validation parameters were evaluated. Results were within the acceptable limits of international guidelines. A significant decrease in clearance led to a significant 2.26-times increase in AUC0 - 6h of olanzapine-loaded lipid-core nanocapsules compared with free-olanzapine.

  2. Investigation of journal orbit and flow pattern in a dynamically loaded journal bearing

    DEFF Research Database (Denmark)

    Christiansen, Christian Kim; Walther, Jens Honore; Klit, Peder

    2017-01-01

    A hydrodynamic journal bearing has been investigated using both the traditional two-dimensional (2D) Reynolds equation, and the full solution being the three-dimensional (3D) Navier-Stokes equations. The two approaches are compared by performing an investigation of two inlet groove designs......: the axial and the circumferential groove, respectively, on a bearing with length-to-diameter ratio of 0.5 exposed to a sinusoidal load pattern. Pressure distributions, journal orbits and frictional losses are compared. The modelling of grooves by pressure boundary conditions versus geometric conditions...... is examined. It is investigated if the presence of a groove increases frictional losses and the increase relates to groove dimensions. Furthermore, the influence of the groove design on the flow field is studied using the 3D solution....

  3. Cognitive load and autonomic response patterns under negative priming demand in depersonalization-derealization disorder.

    Science.gov (United States)

    Lemche, Erwin; Sierra-Siegert, Mauricio; David, Anthony S; Phillips, Mary L; Gasston, David; Williams, Steven C R; Giampietro, Vincent P

    2016-04-01

    Previous studies have yielded evidence for cognitive processing abnormalities and alterations of autonomic functioning in depersonalization-derealization disorder (DPRD). However, multimodal neuroimaging and psychophysiology studies have not yet been conducted to test for functional and effective connectivity under cognitive stress in patients with DPRD. DPRD and non-referred control subjects underwent a combined Stroop/negative priming task, and the neural correlates of Stroop interference effect, negative priming effect, error rates, cognitive load span and average amplitude of skin conductance responses were ascertained for both groups. Evoked haemodynamic responses for basic Stroop/negative priming activations were compared. For basic Stroop to neutral contrast, patients with DPRD differed in the location (inferior vs. superior lobule) of the parietal region involved, but showed similar activations in the left frontal region. In addition, patients with DPRD also co-activated the dorsomedial prefrontal cortex (BA9) and posterior cingulate cortex (BA31), which were also found to be the main between-group difference regions. These regions furthermore showed connectivity with frequency of depersonalization states. Evoked haemodynamic responses drawn from regions of interest indicated significant between-group differences in 30-40% of time points. Brain-behaviour correlations differed mainly in laterality, yet only slightly in regions. A reversal of autonomic patterning became evident in patients with DPRD for cognitive load spans, indicating less effective arousal suppression under cognitive stress - patients with DPRD showed positive associations of cognitive load with autonomic responses, whereas controls exhibit respective inverse association. Overall, the results of the present study show only minor executive cognitive peculiarities, but further support the notion of abnormalities in autonomic functioning in patients with DPRD.

  4. Influence of a training session on postural stability and foot loading patterns in soccer players

    Directory of Open Access Journals (Sweden)

    Vanessa K.N. Petry

    2016-03-01

    Full Text Available Sport specific movements coming along with characteristic plantar pressure distribution and a fatigue of muscles result in an increasing postural sway and therefore lead to a decrease in balance control. Although single soccer specific movements were expatiated with respect to these parameters, no information is available for a complete training session. The objective of the present observational study was to analyze the direct influence of soccer training on postural stability and gait patterns and whether or not these outcomes were altered by age. One hundred and eighteen experienced soccer players participated in the study and were divided into two groups. Group 1 contained 64 soccer players (age 13.31±0.66 years and Group 2 contains 54 ones (age 16.74±0.73 years. Postural stability, static plantar pressure distribution and dynamic foot loading patterns were measured. Our results showed that the soccer training session, as well as the age, has relevant influence on postural stability, while the age only (excluding the training has an influence on static plantar pressure distribution. The parameters of dynamic assessment seem therefore to be affected by age, training and a combination of both. Training and young age correlate with a decreased postural stability; they lead to a significant increase of peak pressure in the previously most loaded areas, and, after reaching a certain age and magnitude of absolute values, to a change in terminal stance and preswing phase of the roll-over. Moreover, younger players show an inhomogenous static plantar pressure distribution which might be the result of the decreased postural control in the young age.

  5. Hyaluronic Acid/PLGA Core/Shell Fiber Matrices Loaded with EGCG Beneficial to Diabetic Wound Healing.

    Science.gov (United States)

    Shin, Yong Cheol; Shin, Dong-Myeong; Lee, Eun Ji; Lee, Jong Ho; Kim, Ji Eun; Song, Sung Hwa; Hwang, Dae-Youn; Lee, Jun Jae; Kim, Bongju; Lim, Dohyung; Hyon, Suong-Hyu; Lim, Young-Jun; Han, Dong-Wook

    2016-12-01

    During the last few decades, considerable research on diabetic wound healing strategies has been performed, but complete diabetic wound healing remains an unsolved problem, which constitutes an enormous biomedical burden. Herein, hyaluronic acid (HA)/poly(lactic-co-glycolic acid, PLGA) core/shell fiber matrices loaded with epigallocatechin-3-O-gallate (EGCG) (HA/PLGA-E) are fabricated by coaxial electrospinning. HA/PLGA-E core/shell fiber matrices are composed of randomly-oriented sub-micrometer fibers and have a 3D porous network structure. EGCG is uniformly dispersed in the shell and sustainedly released from the matrices in a stepwise manner by controlled diffusion and PLGA degradation over four weeks. EGCG does not adversely affect the thermomechanical properties of HA/PLGA-E matrices. The number of human dermal fibroblasts attached on HA/PLGA-E matrices is appreciably higher than that on HA/PLGA counterparts, while their proliferation is steadily retained on HA/PLGA-E matrices. The wound healing activity of HA/PLGA-E matrices is evaluated in streptozotocin-induced diabetic rats. After two weeks of surgical treatment, the wound areas are significantly reduced by the coverage with HA/PLGA-E matrices resulting from enhanced re-epithelialization/neovascularization and increased collagen deposition, compared with no treatment or HA/PLGA. In conclusion, the HA/PLGA-E matrices can be potentially exploited to craft strategies for the acceleration of diabetic wound healing and skin regeneration.

  6. Parallel Processing Performance on Multi-Core PC Cluster Distributing Communication Load to Multiple Paths

    Science.gov (United States)

    Fukunaga, Takafumi

    Due to advent of powerful Multi-Core PC cluster the computation performance of each node is dramatically increassed and this trend will continue in the future. On the other hand, the use of powerful network systems (Myrinet, Infiniband, etc.) is expensive and tends to increase difficulty of programming and degrades portability because they need dedicated libraries and protocol stacks. This paper proposes a relatively simple method to improve bandwidth-oriented parallel applications by improving the communication performance without the above dedicated hardware, libraries, protocol stacks and IEEE802.3ad (LACP). Although there are similarities between this proposal and IEEE802.3ad in respect to using multiple Ethernet ports, the proposal performs equal to or better than IEEE802.3ad without LACP switches and drivers. Moreover the performance of LACP is influenced by the environment (MAC addresses, IP addresses, etc.) because its distribution algorithm uses these parameters, the proposed method shows the same effect in spite of them.

  7. Sensitive enzyme immunoassay for hepatitis B virus core-related antigens and their correlation to virus load.

    Science.gov (United States)

    Kimura, Tatsuji; Rokuhara, Akinori; Sakamoto, Yoko; Yagi, Shintaro; Tanaka, Eiji; Kiyosawa, Kendo; Maki, Noboru

    2002-02-01

    A sensitive enzyme immunoassay (EIA) specific for hepatitis B virus core antigen (HBcAg) and hepatitis B e antigen (HBeAg) was developed. We designated the precore/core gene products as hepatitis B virus (HBV) core-related antigens (HBcrAg). In order to detect HBcrAg even in anti-HBc/e antibody-positive specimens, the specimens were pretreated in detergents. The antibodies are inactivated by this pretreatment and, simultaneously, the antigens are released and the epitopes are exposed. The assay demonstrated 71 to 112% recovery using HBcrAg-positive sera. We observed no interference from the tested anticoagulants or blood components. When the cutoff value was tentatively set at 10(3) U/ml, all healthy control (HBsAg/HBV-DNA negative; n = 108) and anti-HCV antibody-positive (n = 59) sera were identified as negative. The assay showed a detection limit of 4 x 10(2) U/ml using recombinant antigen. Detection limits were compared in four serially diluted HBV high-titer sera. The HBcrAg assay demonstrated higher sensitivity than HBV-DNA transcription-mediated amplification (TMA) or HBeAg radio immunoassay (RIA) in the dilution test. HBcrAg concentrations correlated well with HBV-DNA TMA (r = 0.91, n = 29) and in-house real-time detection-PCR (r = 0.93, n = 47) in hepatitis B patients. On HBeAg/anti-HBe antibody seroconversion panels, the HBcrAg concentration changed in accordance with HBV-DNA levels. HBcrAg concentration provides a reflection of HBV virus load equivalent to HBV-DNA level, and the assay therefore offers a simple method for monitoring hepatitis B patients.

  8. Goblet cell targeting nanoparticle containing drug-loaded micelle cores for oral delivery of insulin.

    Science.gov (United States)

    Zhang, Peiwen; Xu, Yining; Zhu, Xi; Huang, Yuan

    2015-12-30

    Oral administration of insulin remains a challenge due to its poor enzymatic stability and inefficient permeation across epithelium. We herein developed a novel self-assembled polyelectrolyte complex nanoparticles by coating insulin-loaded dodecylamine-graft-γ-polyglutamic acid micelles with trimethyl chitosan (TMC). The TMC material was also conjugated with a goblet cell-targeting peptide to enhance the affinity of nanoparticles with epithelium. The developed nanoparticle possessed significantly enhanced colloid stability, drug protection ability and ameliorated drug release profile compared with graft copolymer micelles or ionic crosslinked TMC nanoparticles. For in vitro evaluation, Caco-2/HT29-MTX-E12 cell co-cultures, which composed of not only enterocyte-like cells but also mucus-secreting cells and secreted mucus layer, were applied to mimic the epithelium. Intracellular uptake and transcellular permeation of encapsulated drug were greatly enhanced for NPs as compared with free insulin or micelles. Goblet cell-targeting modification further increased the affinity of NPs with epithelium with changed cellular internalization mechanism. The influence of mucus on the cell uptake was also investigated. Ex vivo performed with rat mucosal tissue demonstrated that the nanoparticle could facilitate the permeation of encapsulated insulin across the intestinal epithelium. In vivo study preformed on diabetic rats showed that the orally administered nanoparticles elicited a prolonged hypoglycemic response with relative bioavailability of 7.05%.

  9. Hyaluronidase enzyme core-5-fluorouracil-loaded chitosan-PEG-gelatin polymer nanocomposites as targeted and controlled drug delivery vehicles.

    Science.gov (United States)

    Rajan, M; Raj, V; Al-Arfaj, Abdullah A; Murugan, A M

    2013-09-10

    This study examines the performance of novel hyaluronidase enzyme core-5-fluorouracil-loaded chitosan-polyethylene glycol-gelatin polymer nanocomposites, which were prepared using an ionic gelation technique, as targeted and controlled drug delivery vehicles. These hyaluronidase-loaded nanoparticles have recently been proposed as targeted and controlled drug delivery vehicle systems to tissues due to their ability to loosen the intercellular connective matrix of hyaluronic acid. The encapsulation efficiency and loading capacities of the nanoparticles demonstrated that these nanocomposites displayed sufficient binding ability, which depends on the pH and initial concentration of the drug. The cytotoxic effects of the chitosan-hyaluronidase-5-fluorouracil (CS-HYL-5-FU), chitosan-hyaluronidase-5-fluorouracil polyethylene glycol (CS-HYL-5-FU-PEG), and chitosan-hyaluronidase-5-fluorouracil polyethylene glycol-gelatin (CS-HYL-5-FU-PEG-G) nanoparticles were assessed using MTT assays, and the nanovectors were found to be less cytotoxic than the chemotherapeutic 5-FU after incubation for 3-12h. The particle sizes of the CS-HYL-5-FU, CS-HYL-5-FU-PEG and CS-HYL-5-FU-PEG-G polymer composites were between 300 and 580 nm, as determined by a Zetasizer. Scanning electron microscopy (SEM) analysis indicated that the nanocomposites exhibit a clear, smooth surface and fine morphology. Linkages of the polymers, enzyme, and drug were confirmed by FTIR spectroscopy. Atomic fluorescence microscopy (AFM) analysis confirmed the size of the polymer composite nanoparticles. Therefore, this work established that the drug can be successfully encapsulated in chitosan-polyethylene glycol-gelatin-accompanied hyaluronidase nanoparticles with a homogeneous distribution. These nanoparticles can be potential carriers for targeted and controlled drug delivery to cancer cells.

  10. The Pattern as a Reusable Component to Adaptive Framework for Load Balancing Mobile Agent in Internet Banking

    Directory of Open Access Journals (Sweden)

    A. Meiappane

    2012-03-01

    Full Text Available In recent years, the Software Architecture (SA of an Internet banking has become one of the most challengeable and risky fields of modern technology. The advent of the Internet has revolutionized the way banking is being done. In Internet banking, we analyzed some attributes such as usage, security, availability, load balancing and so on. Among those attributes Load Balancing is a serious problem in the Internet and it is necessary to build new systems incorporating load balancing as integral part of their design. The use of patterns, which is of a reusable component, is a good tool to help designers build load balancing systems. In this paper we are going to propose cluster load balancing technique by using mobile agent.

  11. A latency analysis for M2M and OG-like traffic patterns in different HSPA core network configurations

    Directory of Open Access Journals (Sweden)

    M. V. Popović

    2014-11-01

    Full Text Available In this paper we present an analysis intended to reveal possible impacts of core network features on latency for modelled M2M and Online Gaming traffic. Simulations were performed in a live 3G/HSPA network. Test traffic simulating multiplayer real-time games and M2M applications was generated on 10 mobile phones in parallel, sending data to a remote server. APNs with different combinations of hardware and features (proxy server, different GGSNs and firewalls, usage of Service Awareness feature were chosen. The traffic was recorded on the Gn interface in the mobile core. The goal of experiments was to evaluate any eventually significant variation of average recorded RTTs in the core part of mobile network that would clearly indicate either the impact of used APN on delay for a specific traffic pattern, or selectivity of the APN towards different traffic patterns.

  12. Pattern formation with repulsive soft-core interactions: Discrete particle dynamics and Dean-Kawasaki equation

    Science.gov (United States)

    Delfau, Jean-Baptiste; Ollivier, Hélène; López, Cristóbal; Blasius, Bernd; Hernández-García, Emilio

    2016-10-01

    Brownian particles interacting via repulsive soft-core potentials can spontaneously aggregate, despite repelling each other, and form periodic crystals of particle clusters. We study this phenomenon in low-dimensional situations (one and two dimensions) at two levels of description: by performing numerical simulations of the discrete particle dynamics and by linear and nonlinear analysis of the corresponding Dean-Kawasaki equation for the macroscopic particle density. Restricting to low dimensions and neglecting fluctuation effects, we gain analytical insight into the mechanisms of the instability leading to clustering which turn out to be the interplay among diffusion, the intracluster forces, and the forces between neighboring clusters. We show that the deterministic part of the Dean-Kawasaki equation provides a good description of the particle dynamics, including width and shape of the clusters and over a wide range of parameters, and analyze with weakly nonlinear techniques the nature of the pattern-forming bifurcation in one and two dimensions. Finally, we briefly discuss the case of attractive forces.

  13. A Comparative Study on the Selected Area Electron Diffraction Pattern of Fe Oxide/Au Core-shell Structured Nanoparticles

    Institute of Scientific and Technical Information of China (English)

    Qianghua LU; Kailun YAO; Dong XI; Zuli LIU; Xiaoping LUO; Qin NING

    2007-01-01

    The selected area electron diffraction (SAED) pattern of magnetic iron oxide core/gold shell nanoparticles has been studied. For the composite particles with mean size less than 10 nm, their SAED pattern is found to be different from either the pattern of pure Fe oxide nanoparticles or that of pure Au particles. Based on the fact that the ring diameters of these composite particles fit the characteristic relation for the fcc structure, the Au atoms on surfaces of the concerned particles are supposed to pack in a way more tightly than they usually do in pure Au nanoparticles. The driving force for this is the coherency strain which enables the shell material at the heterostructured interface to adapt the lattice parameters of the core.

  14. Microtrauma stimulates rat Achilles tendon healing via an early gene expression pattern similar to mechanical loading

    DEFF Research Database (Denmark)

    Hammerman, Malin; Aspenberg, Per; Eliasson, Pernilla

    2014-01-01

    . Sixteen of the 19 genes were regulated after 3 h, in the same way as after loading. In conclusion, needling increased strength, and there was a striking similarity between the gene expression response to needling and mechanical loading. This suggests that the response to loading in early tendon healing...

  15. A High-Order Theory for the Analysis of Circular Cylindrical Composite Sandwich Shells with Transversely Compliant Core Subjected to External Loads

    DEFF Research Database (Denmark)

    Rahmani, Omid; Khalili, S.M.R.; Thomsen, Ole Thybo

    2012-01-01

    , in contrast to most of the available sandwich plate and shell theories, no prior assumptions are made with respect to the displacement field in the core. Herein the displacement and the stress fields of the core material are determined through a 3D elasticity solution. The performance of the present theory......A new model based on the high order sandwich panel theory is proposed to study the effect of external loads on the free vibration of circular cylindrical composite sandwich shells with transversely compliant core, including also the calculation of the buckling loads. In the present model...... is compared with that of other sandwich theories by the presentation of comparative results obtained for several examples encompassing different material properties and geometric parameters. It is shown that the present model produce results of very high accuracy, and it is suggested that the present model...

  16. The use of Electronic Speckle Pattern Interferometry (ESPI) to determine the displacements in thin adhesive layers under increasing loads (Posterpresentatie)

    NARCIS (Netherlands)

    Botter, H.; Wijen, H.L.M.; Berg, A. van den; Soetens, F.; Straalen, IJ.J. van; Vlot, A.

    2001-01-01

    Recent developments in hardware and software have allowed traditional speckle pattern. interferom.etry using photographic film to be replaced by digital video CCD cameras and sophisticated analysing software. Real-time in-situ displacement measurement of specimens under static or cyclic loads is now

  17. Multi-Core Programming Design Patterns: Stream Processing Algorithms for Dynamic Scene Perceptions

    Science.gov (United States)

    2014-05-01

    image retrieval applications. Several integral histogram kernels using CUDA optimizations for many core GPUs were investigated. The integral histogram...subwindow sizes using Compute Unified Device Architecture ( CUDA ) for many core Graphics Processing Units ( GPU ) with various kernel optimizations. The...developed, for the multicore Cell/B.E. and many core GPU using CUDA . The Cell/B.E. implementation using cross-weave scan and 16 bins for a 640x480 image

  18. Research on PWR Core Performance With MOX Fuel Loading%MOX燃料对压水堆堆芯性能影响研究

    Institute of Scientific and Technical Information of China (English)

    李小生; 靳忠敏

    2013-01-01

    Use of MOX fuel in nuclear reactors is an effective way to dispose of plutonium .A large PWR reactor core with full core loading UO 2 fuel was referenced , the reactor core physics parameters of PWR with whole and part core loading MOX fuel were calculated by using DRAGON and DONJON codes ,and the reactivity worth of control rods and boron acid solution were researched under loading MOX fuel . The results show that PWR core with MOX fuel can achieve the desired cycle length and power distribution ,but loading MOX fuel will significantly decrease the reactivity worth of control rod and boron acid solution ,moreover ,the proportion of loading MOX fuel is positive to the decrease degree of reactivity worth .%在核反应堆中使用MOX燃料是处置钚的有效方式。以大型全UO2燃料压水堆堆芯设计作为参考,使用DRAGON、DONJON程序,计算在大型压水堆中全堆芯及部分堆芯装载MOX燃料后反应堆部分物理性能指标,研究加入MOX燃料后对控制棒与硼酸溶液的反应性价值的影响。结果表明,压水堆堆芯装载各比例MOX燃料均可达到与全UO2燃料堆芯相当的循环长度,功率分布也能满足相应的安全限值要求,但采用MOX燃料会造成控制棒与硼溶液的反应性价值降低,且降低程度与MOX燃料装载比例成正相关。

  19. Chitosan-functionalised poly(2-hydroxyethyl methacrylate) core-shell microgels as drug delivery carriers: salicylic acid loading and release.

    Science.gov (United States)

    Mahattanadul, Natshisa; Sunintaboon, Panya; Sirithip, Piyawan; Tuchinda, Patoomratana

    2016-09-01

    This work presents the evaluation of chitosan-functionalised poly(2-hydroxyethyl methacrylate) (CS/PHEMA) core-shell microgels as drug delivery carriers. CS/PHEMA microgels were prepared by emulsifier-free emulsion polymerisation with N,N '-methylenebisacrylamide (MBA) as a crosslinker. The study on drug loading, using salicylic acid (SA) as a model drug, was performed. The results showed that the encapsulation efficiency (EE) increased as drug-to-microgel ratio was increased. Higher EE can be achieved with the increase in degree of crosslinking, by increasing the amount of MBA from 0.01 g to 0.03 g. In addition, the highest EE (61.1%) was observed at pH 3. The highest release of SA (60%) was noticed at pH 2.4, while the lowest one (49.4%) was obtained at pH 7.4. Moreover, the highest release of SA was enhanced by the presence of 0.2 M NaCl. The pH- and ionic-sensitivity of CS/PHEMA could be useful as a sustained release delivery device, especially for oral delivery.

  20. A finite element model for independent wire rope core with double helical geometry subjected to axial loads

    Indian Academy of Sciences (India)

    Cengiz Erdonmez; C Erdem Imrak

    2011-12-01

    Due to the complex geometry of wires within a wire rope, it is difficult to model and analyse independent wire rope core accurately (IWRC). In this paper, a more realistic three-dimensional modelling approach and finite element analysis of wire ropes are explained. Single helical geometry is enough to model simple straight strand while IWRC has a more complex geometry by inclusion of double helical wires in outer strands. Taking the advantage of the double helical wires, three-dimensional IWRCs modelling is applied for both right regular lay and lang lay IWRCs. Wire-by-wire based results are gathered by using the proposed modelling and analysis method under various loading conditions. Illustrative examples are given for those show the accuracy and the robustness of the present FE analysis scheme with considering frictional properties and contact interactions between wires. FE analysis results are compared with the analytical and available test results and show reasonable agreement with a simpler and more practical approach.

  1. Effect of cyclic loading on fracture strength and microleakage of a quartz fiber dowel with different adhesive, cement and resin core material combinations.

    Science.gov (United States)

    Baldissara, P; Ozcan, M; Melilli, D; Valandro, L F

    2010-01-01

    This study evaluated the performance of different adhesive-cement-core combinations coupled with quartz fiber dowels after cyclic loading and fracture strength tests and assessed the microleakage using dye penetration method. Forty maxillary canines (N=10 per group) were restored with fiber dowels (Quartz fiber DT Light Post) and four adhesive-cement-core material combinations (Group 1: All-Bond 2+C&B [root]/All-Bond 2+Biscore [core]; Group 2: All-Bond 2+Bisfil 2B [root]/All-Bond 2+Bisfil 2B [core]; Group 3: Scotchbond 1+RelyX ARC [root]/Scotchbond 1+Supreme [core]; Group 4: RelyX Unicem [root]/Scotchbond 1+Filtek Supreme [core]). The specimens were initially cyclic loaded (x2,000,000, 8 Hz, 3 to 100 N at 45 °C under 37±3 °C water irrigation) and then immersed in 0.5% basic fuchsine at 37 °C for 24 hours for dye penetration and interface failure detection. The failure surfaces were observed under the stereomicroscope (x100 magnification). Circumferential and centripetal dye penetration was scored at the buccal and lingual sites. Only three specimens failed macroscopically during cyclic loading. No significant difference was found among the groups for the number of resisted cycles (P=0.9). Mean fracture strength between the groups were also not statistically significant (213±63-245±71 N) (P=0.740) (ANOVA). All four groups showed high values of dye penetration along the restoration interfaces being not significant from each other (P=0.224) (Kruskal-Wallis). The lingual sides of the teeth where the load applied, showed significantly higher incidence of detachment between the core and the dentin (100%, 90%, 100%, 90% for groups 1, 2, 3, 4, respectively) compared to the buccal side (30%, 30%, 60%, 40%) (P=0.032, c2 test). In 13 specimens (32.5%) crack lines at the coronal area were observed. Fracture strength was not significantly correlated with dye penetration (P=0.1803, r=-0.2162, Linear Regression and Correlation test). Different combinations of adhesive

  2. Axial loading verification method for small bones using carrier fringes in speckle pattern interferometry

    Science.gov (United States)

    Dávila, A.; Márquez, S.; Landgrave, E.; Vázquez, Z.; Vera, K.; Caudillo, C.

    2015-06-01

    A computerized system for real-time displacement visualization using carrier fringes in an electronic speckle in-plane sensitive interferometer allows force calibration for micro-displacement analysis of rat bones and verification of axial loading conditions. Once the force has been calibrated and the load is applied along the bone axis, the difference-of-phase method is used to obtain the phase map, which after phase unwrapping, allows the evaluation of the displacements produced by the bone deformation. The proposed method avoids common loading mistakes using first carrier fringes to assure that the loads are within the measuring capabilities of the in-plane interferometer and the Carré phase-stepping method to compensate for linear phase step miscalibration. The experimental results obtained with the calibration of loading forces and axial loading verification show the advantages of the system proposed here over a system which uses a cantilever configuration to make a similar bone deformation analysis.

  3. Methotrexate diethyl ester-loaded lipid-core nanocapsules in aqueous solution increased antineoplastic effects in resistant breast cancer cell line

    Science.gov (United States)

    Yurgel, Virginia C; Oliveira, Catiuscia P; Begnini, Karine R; Schultze, Eduarda; Thurow, Helena S; Leon, Priscila MM; Dellagostin, Odir A; Campos, Vinicius F; Beck, Ruy CR; Guterres, Silvia S; Collares, Tiago; Pohlmann, Adriana R; Seixas, Fabiana K

    2014-01-01

    Breast cancer is the most frequent cancer affecting women. Methotrexate (MTX) is an antimetabolic drug that remains important in the treatment of breast cancer. Its efficacy is compromised by resistance in cancer cells that occurs through a variety of mechanisms. This study evaluated apoptotic cell death and cell cycle arrest induced by an MTX derivative (MTX diethyl ester [MTX(OEt)2]) and MTX(OEt)2-loaded lipid-core nanocapsules in two MTX-resistant breast adenocarcinoma cell lines, MCF-7 and MDA-MB-231. The formulations prepared presented adequate granulometric profile. The treatment responses were evaluated through flow cytometry. Relying on the mechanism of resistance, we observed different responses between cell lines. For MCF-7 cells, MTX(OEt)2 solution and MTX(OEt)2-loaded lipid-core nanocapsules presented significantly higher apoptotic rates than untreated cells and cells incubated with unloaded lipid-core nanocapsules. For MDA-MB-231 cells, MTX(OEt)2-loaded lipid-core nanocapsules were significantly more efficient in inducing apoptosis than the solution of the free drug. S-phase cell cycle arrest was induced only by MTX(OEt)2 solution. The drug nanoencapsulation improved apoptosis induction for the cell line that presents MTX resistance by lack of transport receptors. PMID:24741306

  4. Biaxial flexural strength and phase transformation of Ce-TZP/Al2O3 and Y-TZP core materials after thermocycling and mechanical loading.

    Science.gov (United States)

    Bankoğlu Güngör, Merve; Yılmaz, Handan; Aydın, Cemal; Karakoca Nemli, Seçil; Turhan Bal, Bilge; Tıraş, Tülay

    2014-06-01

    The purpose of the present study was to evaluate the effect of thermocycling and mechanical loading on the biaxial flexural strength and the phase transformation of one Ce-TZP/Al2O3 and two Y-TZP core materials. Thirty disc-shaped specimens were obtained from each material. The specimens were randomly divided into three groups (control, thermocycled, and mechanically loaded). Thermocycling was subjected in distilled water for 10000 cycles. Mechanical loading was subjected with 200 N loads at a frequency of 2 Hz for 100000 times. The mean biaxial flexural strength and phase transformation of the specimens were tested. The Weibull modulus, characteristic strength, 10%, 5% and 1% probabilities of failure were calculated using the biaxial flexural strength data. The characteristic strengths of Ce-TZP/Al2O3 specimens were significantly higher in all groups compared with the other tested materials (Pstrength of the tested materials.

  5. Classification of Promoters Based on the Combination of Core Promoter Elements Exhibits Different Histone Modification Patterns

    Science.gov (United States)

    Natsume-Kitatani, Yayoi; Mamitsuka, Hiroshi

    2016-01-01

    Four different histones (H2A, H2B, H3, and H4; two subunits each) constitute a histone octamer, around which DNA wraps to form histone-DNA complexes called nucleosomes. Amino acid residues in each histone are occasionally modified, resulting in several biological effects, including differential regulation of transcription. Core promoters that encompass the transcription start site have well-conserved DNA motifs, including the initiator (Inr), TATA box, and DPE, which are collectively called the core promoter elements (CPEs). In this study, we systematically studied the associations between the CPEs and histone modifications by integrating the Drosophila Core Promoter Database and time-series ChIP-seq data for histone modifications (H3K4me3, H3K27ac, and H3K27me3) during development in Drosophila melanogaster via the modENCODE project. We classified 96 core promoters into four groups based on the presence or absence of the TATA box or DPE, calculated the histone modification ratio at the core promoter region, and transcribed region for each core promoter. We found that the histone modifications in TATA-less groups were static during development and that the core promoters could be clearly divided into three types: i) core promoters with continuous active marks (H3K4me3 and H3K27ac), ii) core promoters with a continuous inactive mark (H3K27me3) and occasional active marks, and iii) core promoters with occasional histone modifications. Linear regression analysis and non-linear regression by random forest showed that the TATA-containing groups included core promoters without histone modifications, for which the measured RNA expression values were not predictable accurately from the histone modification status. DPE-containing groups had a higher relative frequency of H3K27me3 in both the core promoter region and transcribed region. In summary, our analysis showed that there was a systematic link between the existence of the CPEs and the dynamics, frequency and influence

  6. Classification of Promoters Based on the Combination of Core Promoter Elements Exhibits Different Histone Modification Patterns.

    Directory of Open Access Journals (Sweden)

    Yayoi Natsume-Kitatani

    Full Text Available Four different histones (H2A, H2B, H3, and H4; two subunits each constitute a histone octamer, around which DNA wraps to form histone-DNA complexes called nucleosomes. Amino acid residues in each histone are occasionally modified, resulting in several biological effects, including differential regulation of transcription. Core promoters that encompass the transcription start site have well-conserved DNA motifs, including the initiator (Inr, TATA box, and DPE, which are collectively called the core promoter elements (CPEs. In this study, we systematically studied the associations between the CPEs and histone modifications by integrating the Drosophila Core Promoter Database and time-series ChIP-seq data for histone modifications (H3K4me3, H3K27ac, and H3K27me3 during development in Drosophila melanogaster via the modENCODE project. We classified 96 core promoters into four groups based on the presence or absence of the TATA box or DPE, calculated the histone modification ratio at the core promoter region, and transcribed region for each core promoter. We found that the histone modifications in TATA-less groups were static during development and that the core promoters could be clearly divided into three types: i core promoters with continuous active marks (H3K4me3 and H3K27ac, ii core promoters with a continuous inactive mark (H3K27me3 and occasional active marks, and iii core promoters with occasional histone modifications. Linear regression analysis and non-linear regression by random forest showed that the TATA-containing groups included core promoters without histone modifications, for which the measured RNA expression values were not predictable accurately from the histone modification status. DPE-containing groups had a higher relative frequency of H3K27me3 in both the core promoter region and transcribed region. In summary, our analysis showed that there was a systematic link between the existence of the CPEs and the dynamics, frequency

  7. Metapopulation theory identifies biogeographical patterns among core and satellite marine bacteria scaling from tens to thousands of kilometers

    DEFF Research Database (Denmark)

    Lindh, Markus V.; Sjöstedt, Johanna; Ekstam, Börje

    2017-01-01

    with a satellite mode of rare endemic populations and a core mode of abundant cosmopolitan populations (e.g. Synechococcus, SAR11 and SAR86 clade members). Temporal changes in population distributions supported several theoretical frameworks. Still, bimodality was found among bacterioplankton communities across......Metapopulation theory developed in terrestrial ecology provides applicable frameworks for interpreting the role of local and regional processes in shaping species distribution patterns. Yet, empirical testing of metapopulation models on microbial communities is essentially lacking. We determined...

  8. Ultrasound-guided diagnostic breast biopsy methodology: retrospective comparison of the 8-gauge vacuum-assisted biopsy approach versus the spring-loaded 14-gauge core biopsy approach

    Science.gov (United States)

    2011-01-01

    Background Ultrasound-guided diagnostic breast biopsy technology represents the current standard of care for the evaluation of indeterminate and suspicious lesions seen on diagnostic breast ultrasound. Yet, there remains much debate as to which particular method of ultrasound-guided diagnostic breast biopsy provides the most accurate and optimal diagnostic information. The aim of the current study was to compare and contrast the 8-gauge vacuum-assisted biopsy approach and the spring-loaded 14-gauge core biopsy approach. Methods A retrospective analysis was done of all ultrasound-guided diagnostic breast biopsy procedures performed by either the 8-gauge vacuum-assisted biopsy approach or the spring-loaded 14-gauge core biopsy approach by a single surgeon from July 2001 through June 2009. Results Among 1443 ultrasound-guided diagnostic breast biopsy procedures performed, 724 (50.2%) were by the 8-gauge vacuum-assisted biopsy technique and 719 (49.8%) were by the spring-loaded 14-gauge core biopsy technique. The total number of false negative cases (i.e., benign findings instead of invasive breast carcinoma) was significantly greater (P = 0.008) in the spring-loaded 14-gauge core biopsy group (8/681, 1.2%) as compared to in the 8-gauge vacuum-assisted biopsy group (0/652, 0%), with an overall false negative rate of 2.1% (8/386) for the spring-loaded 14-gauge core biopsy group as compared to 0% (0/148) for the 8-gauge vacuum-assisted biopsy group. Significantly more (P biopsy group (81/719, 11.3%) than in the 8-gauge vacuum-assisted biopsy group (18/724, 2.5%) were recommended for further diagnostic surgical removal of additional tissue from the same anatomical site of the affected breast in an immediate fashion for indeterminate/inconclusive findings seen on the original ultrasound-guided diagnostic breast biopsy procedure. Significantly more (P biopsy group (54/719, 7.5%) than in the 8-gauge vacuum-assisted biopsy group (9/724, 1.2%) personally requested further

  9. Magnetic nanohybrids loaded with bimetal core-shell-shell nanorods for bacteria capture, separation, and near-infrared photothermal treatment.

    Science.gov (United States)

    Hu, Bo; Wang, Ning; Han, Lu; Chen, Ming-Li; Wang, Jian-Hua

    2015-04-20

    A novel antimicrobial nanohybrid based on near-infrared (NIR) photothermal conversion is designed for bacteria capture, separation, and sterilization (killing). Positively charged magnetic reduced graphene oxide with modification by polyethylenimine (rGO-Fe3 O4 -PEI) is prepared and then loaded with core-shell-shell Au-Ag-Au nanorods to construct the nanohybrid rGO-Fe3 O4 -Au-Ag-Au. NIR laser irradiation melts the outer Au shell and exposes the inner Ag shell, which facilitates controlled release of the silver shell. The nanohybrids combine physical photothermal sterilization as a result of the outer Au shell with the antibacterial effect of the inner Ag shell. In addition, the nanohybrid exhibits high heat conductivity because of the rGO and rapid magnetic-separation capability that is attributable to Fe3 O4 . The nanohybrid provides a significant improvement of bactericidal efficiency with respect to bare Au-Ag-Au nanorods and facilitates the isolation of bacteria from sample matrixes. A concentration of 25 μg mL(-1) of nanohybrid causes 100 % capture and separation of Escherichia coli O157:H7 (1×10(8) cfu mL(-1) ) from an aqueous medium in 10 min. In addition, it causes a 22 °C temperature rise for the surrounding solution under NIR irradiation (785 nm, 50 mW cm(-2) ) for 10 min. With magnetic separation, 30 μg mL(-1) of nanohybrid results in a 100 % killing rate for E. coli O157:H7 cells. The facile bacteria separation and photothermal sterilization is potentially feasible for environmental and/or clinical treatment.

  10. Face Sheet/Core Disbond Growth in Honeycomb Sandwich Panels Subjected to Ground-Air-Ground Pressurization and In-Plane Loading

    Science.gov (United States)

    Chen, Zhi M.; Krueger, Ronald; Rinker, Martin

    2015-01-01

    Typical damage modes in light honeycomb sandwich structures include face sheet/core disbonding and core fracture, both of which can pose a threat to the structural integrity of a component. These damage modes are of particular interest to aviation certification authorities since several in-service occurrences, such as rudder structural failure and other control surface malfunctions, have been attributed to face sheet/core disbonding. Extensive studies have shown that face sheet/core disbonding and core fracture can lead to damage propagation caused by internal pressure changes in the core. The increasing use of composite sandwich construction in aircraft applications makes it vitally important to understand the effect of ground-air-ground (GAG) cycles and conditions such as maneuver and gust loads on face sheet/core disbonding. The objective of the present study was to use a fracture mechanics based approach developed earlier to evaluate the loading at the disbond front caused by ground-air-ground pressurization and in-plane loading. A honeycomb sandwich panel containing a circular disbond at one face sheet/core interface was modeled with three-dimensional (3D) solid finite elements. The disbond was modeled as a discrete discontinuity and the strain energy release rate along the disbond front was computed using the Virtual Crack Closure Technique (VCCT). Special attention was paid to the pressure-deformation coupling which can decrease the pressure load within the disbonded sandwich section significantly when the structure is highly deformed. The commercial finite element analysis software, Abaqus/Standard, was used for the analyses. The recursive pressure-deformation coupling problem was solved by representing the entrapped air in the honeycomb cells as filled cavities in Abaqus/Standard. The results show that disbond size, face sheet thickness and core thickness are important parameters that determine crack tip loading at the disbond front. Further, the pressure

  11. Dynamic Patterns of Forces and Loading Rate in Runners with Unilateral Plantar Fasciitis: A Cross-Sectional Study.

    Directory of Open Access Journals (Sweden)

    Ana Paula Ribeiro

    Full Text Available The etiology of plantar fasciitis (PF has been related to several risk factors, but the magnitude of the plantar load is the most commonly described factor. Although PF is the third most-common injury in runners, only two studies have investigated this factor in runners, and their results are still inconclusive regarding the injury stage.Analyze and compare the plantar loads and vertical loading rate during running of runners in the acute stage of PF to those in the chronic stage of the injury in relation to healthy runners.Forty-five runners with unilateral PF (30 acute and 15 chronic and 30 healthy control runners were evaluated while running at 12 km/h for 40 meters wearing standardized running shoes and Pedar-X insoles. The contact area and time, maximum force, and force-time integral over the rearfoot, midfoot, and forefoot were recorded and the loading rate (20-80% of the first vertical peak was calculated. Groups were compared by ANOVAs (p<0.05.Maximum force and force-time integral over the rearfoot and the loading rate was higher in runners with PF (acute and chronic compared with controls (p<0.01. Runners with PF in the acute stage showed lower loading rate and maximum force over the rearfoot compared to runners in the chronic stage (p<0.01.Runners with PF showed different dynamic patterns of plantar loads during running over the rearfoot area depending on the injury stage (acute or chronic. In the acute stage of PF, runners presented lower loading rate and forces over the rearfoot, possibly due to dynamic mechanisms related to pain protection of the calcaneal area.

  12. Time-dependent fracture probability of bilayer, lithium-disilicate-based, glass-ceramic, molar crowns as a function of core/veneer thickness ratio and load orientation.

    Science.gov (United States)

    Anusavice, Kenneth J; Jadaan, Osama M; Esquivel-Upshaw, Josephine F

    2013-11-01

    Recent reports on bilayer ceramic crown prostheses suggest that fractures of the veneering ceramic represent the most common reason for prosthesis failure. The aims of this study were to test the hypotheses that: (1) an increase in core ceramic/veneer ceramic thickness ratio for a crown thickness of 1.6mm reduces the time-dependent fracture probability (Pf) of bilayer crowns with a lithium-disilicate-based glass-ceramic core, and (2) oblique loading, within the central fossa, increases Pf for 1.6-mm-thick crowns compared with vertical loading. Time-dependent fracture probabilities were calculated for 1.6-mm-thick, veneered lithium-disilicate-based glass-ceramic molar crowns as a function of core/veneer thickness ratio and load orientation in the central fossa area. Time-dependent fracture probability analyses were computed by CARES/Life software and finite element analysis, using dynamic fatigue strength data for monolithic discs of a lithium-disilicate glass-ceramic core (Empress 2), and ceramic veneer (Empress 2 Veneer Ceramic). Predicted fracture probabilities (Pf) for centrally loaded 1.6-mm-thick bilayer crowns over periods of 1, 5, and 10 years are 1.2%, 2.7%, and 3.5%, respectively, for a core/veneer thickness ratio of 1.0 (0.8mm/0.8mm), and 2.5%, 5.1%, and 7.0%, respectively, for a core/veneer thickness ratio of 0.33 (0.4mm/1.2mm). CARES/Life results support the proposed crown design and load orientation hypotheses. The application of dynamic fatigue data, finite element stress analysis, and CARES/Life analysis represent an optimal approach to optimize fixed dental prosthesis designs produced from dental ceramics and to predict time-dependent fracture probabilities of ceramic-based fixed dental prostheses that can minimize the risk for clinical failures. Copyright © 2013 Academy of Dental Materials. All rights reserved.

  13. Core-shell hybrid liposomal vesicles loaded with panax notoginsenoside: preparation, characterization and protective effects on global cerebral ischemia/reperfusion injury and acute myocardial ischemia in rats

    OpenAIRE

    Zhang J.; Han XZ; Li X.; Luo Y; Zhao HP; Yang M.; Ni B; Liao ZG

    2012-01-01

    Jing Zhang,1,* Xizhen Han,1,* Xiang Li,2 Yun Luo,1 Haiping Zhao,1 Ming Yang,1 Bin Ni,1 Zhenggen Liao11Key Laboratory of Modern Preparation of TCM, Ministry of Education, 2National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of China*These authors contributed equally to this workPurpose: Novel panax notoginsenoside-loaded core-shell hybrid liposomal vesicles (PNS-HLV)...

  14. STUDY OF HIGHER MODE EFFECTS AND LATERAL LOAD PATTERNS IN PUSHOVER ANALYSIS OF STEEL FRAMES WITH STEEL SHEAR WALL

    Directory of Open Access Journals (Sweden)

    Mohammad Ghanoonibagha

    2016-03-01

    Full Text Available When an earthquake occurs, the structure will enter into a nonlinear stage; therefore, new approaches based on nonlinear analysis are needed to flourish with the purpose of more realistic investigations on seismic behavior and destruction mechanism of structures. According to the modern philosophy, “Performance-based Earthquake Engineering” is formed in which simple nonlinear static analyses are mostly used in order to determine the structure’s behavior in nonlinear stage. This method assumes that the structure response is only controlled by the main mode and the shape of this mode will remain the same, while it enters the nonlinear stage. Both of these assumptions are approximations, especially in high buildings, which have a long period. It seems that constant load pattern used in these methods cannot consider all of the effects properly. In this paper, an attempt was made to study the accuracy of these methods in comparison to nonlinear dynamic analysis, by considering various load patterns existing in FEMA, also load patterns proportional to higher modes in nonlinear static method, and employing an approximative method of MPA modal analysis, study the accuracy of these methods in comparison to nonlinear dynamic analysis. For this purpose, three steel frames of 4, 8, and 12-stories with steel shear wall have been studied.

  15. Fabrication of metronidazole loaded poly (ε-caprolactone)/zein core/shell nanofiber membranes via coaxial electrospinning for guided tissue regeneration.

    Science.gov (United States)

    He, Min; Jiang, Huiyi; Wang, Rui; Xie, Yi; Zhao, Changsheng

    2017-03-15

    To develop a biologically mimetic guided tissue regeneration (GTR) membrane with localized sustained drug release function to prevent infection, coaxial electrospinning technique was conducted to fabricate metronidazole (MNA)-loaded poly (ε-caprolactone) (PCL)/zein core/shell nanofibers. The nanofibers displayed a uniform bead-free round morphology as observed by scanning electron microscopy (SEM), and a core/shell structure as confirmed by transmission electron microscopy (TEM). X-ray diffraction (XRD) and differential scanning calorimetry (DSC) characterizations demonstrated that the MNA was well dispersed in the nanofibers matrix. Due to the encapsulation of the hydrophobic zein, the MNA was released in a controlled, sustained manner over 4days, and the released MNA showed high antibacterial activity towards anaerobic bacteria. In addition, the encapsulation of natural zein resulted in enhanced cell adhesion and proliferation, and the loading of MNA did not show any cytotoxicity. Thus, these results demonstrated that the MNA-loaded core/shell nanofibers had the potential to be used as GTR membranes with antibacterial function for extensive biomedical applications.

  16. Doxorubicin/gold-loaded core/shell nanoparticles for combination therapy to treat cancer through the enhanced tumor targeting.

    Science.gov (United States)

    Kim, Kyungim; Oh, Keun Sang; Park, Dal Yong; Lee, Jae Young; Lee, Beom Suk; Kim, In San; Kim, Kwangmeyung; Kwon, Ick Chan; Sang, Yoon Kim; Yuk, Soon Hong

    2016-04-28

    A combination therapy consisting of radiotherapy and chemotherapy is performed using the core/shell nanoparticles (NPs) containing gold NPs and doxorubicin (DOX). Gold NPs in the core/shell NPs were utilized as a radiosensitizer. To examine the morphology and size distribution of the core/shell NPs, transmittance electron microscopy and dynamic light scattering were used. The in vitro release behavior, cellular uptake and toxicity were also observed to verify the functionality of the core/shell NPs as a nanocarrier. To demonstrate the advantage of the core/shell NPs over traditional gold NPs reported in the combination therapy, we evaluated the accumulation behavior of the core/shell NPs at the tumor site using the biodistribution. Antitumor efficacy was observed with and without radiation to evaluate the role of gold NPs as a radiosensitizer.

  17. Different knee joint loading patterns in ACL deficient copers and non-copers during walking

    DEFF Research Database (Denmark)

    Alkjaer, Tine; Henriksen, Marius; Simonsen, Erik B

    2011-01-01

    Rupture of the anterior cruciate ligament (ACL) causes changes in the walking pattern. ACL deficient subjects classified as copers and non-copers have been observed to adopt different post-injury walking patterns. How these different patterns affect the knee compression and shear forces is unreso......Rupture of the anterior cruciate ligament (ACL) causes changes in the walking pattern. ACL deficient subjects classified as copers and non-copers have been observed to adopt different post-injury walking patterns. How these different patterns affect the knee compression and shear forces...... is unresolved. Thus, the aim of the present study was to investigate how different walking patterns observed between copers, non-copers, and controls affect the knee compression and shear forces during walking....

  18. Development of an Insect Repellent Spray for Textile Based on Permethrin-Loaded Lipid-Core Nanocapsules.

    Science.gov (United States)

    Forgearini, Joana C; Michalowski, Cecília B; Assumpção, Evelise; Pohlmann, Adriana R; Guterres, Silvia S

    2016-02-01

    The aim of this study was to prepare and characterize permethrin-loaded lipid core nanocapsules (P-LNC) in order to produce a long last insect repellent spray formulation for clothes. P-LNC were prepared by self-assembling in aqueous solution showing a mean diameter of 201 +/- 4 nm with a monomodal distribution, a permethrin content of 4.6 +/- 0.1 mg/mL and zeta potential of--16.7 +/- 4 mV. P-LNC (0.46%), as well as the commercial product (0.46%) and the hydroalcoholic solution (0.50%) of permethrin were separately sprayed onto cotton or polyester, followed by successive washes of the fabric. The results showed that the fabrics treated with P-LNC are more resistant than other solutions in terms of remaining permethrin content. After twenty washes, the cotton treated with P-LNC, presented a concentration of 566 +/- 27 mg/M2 of impregnated permethrin, while for the treatment with the substance hydroalcoholic solution and with the commercial product the concentrations values were of 340 +/- 7 mg/M2 and 224 +/- 74 mg/M2, respectively. When the test was performed using polyester, this fiber was less adhesive than cotton, resulting in a final concentration of permethrin (after 20 washes) of 81 +/- 10 mg/m2 for P-LNC suspension, 94 +/- 8 mg/M2 for the substance hydroalcoolic solution and 22 +/- 3 mg/M2 for the commercial product. After impregnating cotton with the formulations and submitting to a temperature of 200 degrees C, the P-LNC also demonstrated higher adherence compared to the other formulations (407 +/- 67 mg/m2 for P-LNC, 236 +/- 72 mg/m2 for the substance hydroalcoholic solution and 158 +/- 62 mg/m2 for commercial product). These results showed that the repellent spray composed of P-LNC developed in this work is a promising and innovative product for the individual protection against insects, useful for impregnation onto cotton garments.

  19. Evaluation of Fugen core management code (POLESTAR)

    Energy Technology Data Exchange (ETDEWEB)

    Shiratori, Yoshitake (Power Reactor and Nuclear Fuel Development Corp., Tsuruga, Fukui (Japan). Fugen Nuclear Power Station); Matsumoto, Mitsuo; Deshimaru, Takehide; Saito, Kuniyoshi

    1991-06-01

    Core management code POLESTAR has been developed by PNC and it has enough functions for core management. The code has been successfully used to carry out core management of Fugen such as making a long term or next cycle fuel loading plan, predicting detailed characteristics of a next cycle core, planning of a control rod pattern and evaluating the core life time after reactor start-up and so on. This code has been contributed to the reliable and economical operation of Fugen, since its accuracy has been checked and the code has been tailored by comparing its calculation results with various measured data. (author).

  20. Distance-decay patterns of nutrient loading at watershed scale: Regression modeling with a special spatial aggregation strategy

    Science.gov (United States)

    Zhang, Tao

    2011-05-01

    SummaryThe effect of distance-decay on nutrient flux usually plays an important role in nutrient retention from non-point sources to surface waters. However, the distance-decay effect has been inappropriately neglected in many studies that adopted regression modeling method to quantify the relationship between watershed landscape and in-stream nutrient loading level. The goal of this study was to develop non-linear regression models that better quantify the role of distance on non-point source nutrient loads in rivers by using simulation results of a spatially-explicit model applied to the watersheds in the Upper Chattahoochee River Basin, Georgia. Because a detailed spatially-explicit modeling approach typically simulates the nutrient flux across the entire watershed, it provides opportunities to examine the nutrient decay patterns at watershed scale. The simulation results confirmed that regarding the effect of flow distance on nutrient loading, the exponential decay setting in the spatially-explicit model performs well. Other heterogeneous factors including slope and soil conditions do affect the decay results but not strongly enough to change the general exponential patterns. The nutrient contribution from areas that were greater than 300 meters to the river network was negligible. It was also found that the decay rate for urban lands is lower than that for other land-covers. Based on these findings, a spatial aggregation strategy in the lateral dimension of the river network was adopted and eight non-linear regression models which explicitly addressed the effects of distance-decay were designed to estimate the nutrient annual average loads. The model validation results showed that three of them can well estimate the nutrient loads. This study shows the usage of stream-lateral-dimension aggregation strategy in addressing nutrient distance-decay patterns and developing simple regression models of nutrient loading. This study also illustrates the advantages of

  1. The sustained-release behavior and in vitro and in vivo transfection of pEGFP-loaded core-shell-structured chitosan-based composite particles

    Directory of Open Access Journals (Sweden)

    Wang Y

    2014-10-01

    Full Text Available Yun Wang,1 Fu-xing Lin,2 Yu Zhao,1 Mo-zhen Wang,2 Xue-wu Ge,2 Zheng-xing Gong,1 Dan-dan Bao,1 Yu-fang Gu1 1Department of Plastic Surgery, First Affiliated Hospital of Anhui Medical University, 2CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China Abstract: Novel submicron core-shell-structured chitosan-based composite particles ­encapsulated with enhanced green fluorescent protein plasmids (pEGFP were prepared by complex coacervation method. The core was pEGFP-loaded thiolated N-alkylated chitosan (TACS and the shell was pH- and temperature-responsive hydroxybutyl chitosan (HBC. pEGFP-loaded TACS-HBC composite particles were spherical, and had a mean diameter of approximately 120 nm, as measured by transmission electron microscopy and particle size analyzer. pEGFP showed sustained release in vitro for >15 days. Furthermore, in vitro transfection in human embryonic kidney 293T and human cervix epithelial cells, and in vivo transfection in mice skeletal muscle of loaded pEGFP, were investigated. Results showed that the expression of loaded pEGFP, both in vitro and in vivo, was slow but could be sustained over a long period. pEGFP expression in mice skeletal muscle was sustained for >60 days. This work indicates that these submicron core-shell-structured chitosan-based composite particles could potentially be used as a gene vector for in vivo controlled gene transfection. Keywords: gene therapy, gene transfection, hydroxybutyl chitosan, thiolated N-alkylated chitosan, pEGFP, complex coacervation

  2. Core regulatory network motif underlies the ocellar complex patterning in Drosophila melanogaster

    Science.gov (United States)

    Aguilar-Hidalgo, D.; Lemos, M. C.; Córdoba, A.

    2015-03-01

    During organogenesis, developmental programs governed by Gene Regulatory Networks (GRN) define the functionality, size and shape of the different constituents of living organisms. Robustness, thus, is an essential characteristic that GRNs need to fulfill in order to maintain viability and reproducibility in a species. In the present work we analyze the robustness of the patterning for the ocellar complex formation in Drosophila melanogaster fly. We have systematically pruned the GRN that drives the development of this visual system to obtain the minimum pathway able to satisfy this pattern. We found that the mechanism underlying the patterning obeys to the dynamics of a 3-nodes network motif with a double negative feedback loop fed by a morphogenetic gradient that triggers the inhibition in a French flag problem fashion. A Boolean modeling of the GRN confirms robustness in the patterning mechanism showing the same result for different network complexity levels. Interestingly, the network provides a steady state solution in the interocellar part of the patterning and an oscillatory regime in the ocelli. This theoretical result predicts that the ocellar pattern may underlie oscillatory dynamics in its genetic regulation.

  3. Non-spherical voids and lattice reorientation patterning in a shock-loaded Al single crystal

    DEFF Research Database (Denmark)

    Hong, Chuanshi; Fæster, Søren; Hansen, Niels

    2017-01-01

    An Al single crystal shock loaded in the direction and captured at incipient spallation was examined by combining X-ray tomography, electron backscatter diffraction on a scanning electron microscope, and transmission electron microscopy (TEM). Octahedral voids with {1 1 1} faces were...

  4. Analysis of Random-Loading HTR-PROTEUS Cores with Continuous Energy Monte Carlo Code Based on A Statistical Geometry Model

    Energy Technology Data Exchange (ETDEWEB)

    Murata, Isao; Miyamaru, Hiroyuki [Division of Electrical, Electronic and Information Engineering, Osaka University, Yamada-oka 2-1, Suita, Osaka, 565-0871 (Japan)

    2008-07-01

    Spherical elements have remarkable features in various applications in the nuclear engineering field. In 1990's, by the project of HTR-PROTEUS at PSI various pebble bed reactor experiments were conducted including cores with a lot of spherical fuel elements loaded randomly. In this study, criticality experiments of the random-loading HTR-PROTEUS cores were analyzed by MCNP-BALL, which could deal with a random arrangement of spherical fuel elements exactly with a statistical geometry model. As a result of analysis, the calculated effective multiplication factors were in fairly good agreement with the measurements within about 0.5%DELTAk/k. In comparison with other numerical analysis, our effective multiplication factors were between the experimental values and the VSOP calculations. To investigate the discrepancy of the effective multiplication factors between the experiments and calculations, sensitivity analyses were performed. As the result, the sensitivity of impurity boron concentration was fairly large. The reason of the present slight overestimation was not made clear at present. However, the presently existing difference was thought to be related to the impurity boron concentration, not to the modelling of the reactor and the used nuclear data. From the present study, it was confirmed that MCNP-BALL would have an advantage to conventional transport codes by comparing with their numerical results and the experimental values. As for the criticality experiment of PROTEUS, we would conclude that the two cores of Core 4.2 and 4.3 could be regarded as an equivalent experiment of a reference critical core, which was packed in the packing fraction of RLP. (authors)

  5. Core-matched encapsulation of an oleate prodrug into nanostructured lipid carriers with high drug loading capability to facilitate the oral delivery of docetaxel.

    Science.gov (United States)

    Sun, Bingjun; Luo, Cong; Li, Lin; Wang, Menglin; Du, Yuqian; Di, Donghua; Zhang, Dong; Ren, Guolian; Pan, Xiaolei; Fu, Qiang; Sun, Jin; He, Zhonggui

    2016-07-01

    Nanostructured lipid carriers (NLC) have been considered as promising vehicles for oral delivery of taxanes, such as docetaxel (DTX). However, the low drug loading capability (∼5%, w/w) has greatly limited their clinical application. In response to this challenge, a novel lipophilic oleate prodrug of DTX (DTX-OA) was synthesized and efficiently encapsulated in NLC using core-match technology, in which liquid lipid (OA) was used as core matrix to enhance compatibility with DTX-OA. DTX-OA-NLC showed uniform particle size of about 100nm with markedly high drug loading capability (∼23% of DTX, w/w) compared with DTX-NLC (∼5%, w/w). Besides, DTX-OA-NLC showed better colloidal stability and slower drug release property compared with DTX-NLC. The prepared NLC could be accumulated more easily in MDCK cells than drug solution, and clathrin-mediated endocytosis was the main endocytosis pathway. In situ single-pass intestinal perfusion (SPIP) and intestinal biodistribution studies demonstrated the improved membrane permeability and intestinal wall bioadhesion of NLCs. The bioavailability of DTX-OA-NLC showed 4.04-fold and 2.06-fold higher than DTX solution and DTX-NLC, respectively. These results suggest that the core-matched prodrug-NLC is a promising platform to facilitate the oral delivery of DTX. Copyright © 2016. Published by Elsevier B.V.

  6. Ecological patterns, diversity and core taxa of microbial communities in groundwater-fed rapid gravity filters

    DEFF Research Database (Denmark)

    Gülay, Arda; Musovic, Sanin; Albrechtsen, Hans-Jørgen;

    2016-01-01

    with ability to oxidize ammonium, nitrite, iron, manganese and methane as primary growth substrate were identified and dominated in both PFs (73.6±6%) and AFs (61.4±21%), suggesting their functional importance. Surprisingly, operational taxonomic unit richness correlated strongly and positively with sampling...... the second most and most abundant fraction in PFs (27±23%) and AFs (45.2±23%), respectively, and were far more abundant than typical proteobacterial ammonium-oxidizing bacteria, suggesting a physiology beyond nitrite oxidation for Nitrospira. Within the core taxa, sequences closely related to types...

  7. Relationships between the Definition of the Hyperplane Width to the Fidelity of Principal Component Loading Patterns.

    Science.gov (United States)

    Richman, Michael B.; Gong, Xiaofeng

    1999-06-01

    When applying eigenanalysis, one decision analysts make is the determination of what magnitude an eigenvector coefficient (e.g., principal component (PC) loading) must achieve to be considered as physically important. Such coefficients can be displayed on maps or in a time series or tables to gain a fuller understanding of a large array of multivariate data. Previously, such a decision on what value of loading designates a useful signal (hereafter called the loading `cutoff') for each eigenvector has been purely subjective. The importance of selecting such a cutoff is apparent since those loading elements in the range of zero to the cutoff are ignored in the interpretation and naming of PCs since only the absolute values of loadings greater than the cutoff are physically analyzed. This research sets out to objectify the problem of best identifying the cutoff by application of matching between known correlation/covariance structures and their corresponding eigenpatterns, as this cutoff point (known as the hyperplane width) is varied.A Monte Carlo framework is used to resample at five sample sizes. Fourteen different hyperplane cutoff widths are tested, bootstrap resampled 50 times to obtain stable results. The key findings are that the location of an optimal hyperplane cutoff width (one which maximized the information content match between the eigenvector and the parent dispersion matrix from which it was derived) is a well-behaved unimodal function. On an individual eigenvector, this enables the unique determination of a hyperplane cutoff value to be used to separate those loadings that best reflect the relationships from those that do not. The effects of sample size on the matching accuracy are dramatic as the values for all solutions (i.e., unrotated, rotated) rose steadily from 25 through 250 observations and then weakly thereafter. The specific matching coefficients are useful to assess the penalties incurred when one analyzes eigenvector coefficients of a

  8. Citation Patterns of Core Communication Journals: An Assessment of the Developmental Status of Communication.

    Science.gov (United States)

    So, Clement Y. K.

    1988-01-01

    Evaluates the developmental status of communication by studying citation patterns both within the field and between communication and other fields. Examines citation linkages of 10 communication journals using the 1983-1985 data from "Social Sciences Citation Index's Journal Citation Reports." (MM)

  9. Age-related worm load and worm fecundity patterns in human populations, as indicated by schistosome circulating antigens

    Directory of Open Access Journals (Sweden)

    Polman Katja

    1998-01-01

    Full Text Available Recently, our group determined the relationship between serum CAA levels and fecal egg counts in two foci with very intense Schistosoma mansoni transmission: Maniema (Zaire, an area endemic for S. mansoni since several decades, and Ndombo (Senegal, where transmission has only been established since a few years. The objective was to study and compare age-related worm load and worm fecundity patterns in these two different endemic settings. Here, we will summarize the most important findings and conclusions of this study.

  10. Reactivity considerations for the on-line refuelling of a pebble bed modular reactor-Illustrating safety for the most reactive core fuel load

    Energy Technology Data Exchange (ETDEWEB)

    Reitsma, Frederik, E-mail: Frederik.Reitsma@pbmr.co.za [Pebble Bed Modular Reactor (Pty) Ltd., PO Box 9396, Centurion 0043 (South Africa)

    2012-10-15

    In the multi-pass fuel management scheme employed for the pebble bed modular reactor the fuel pebbles are re-circulated until they reach the target burn-up. The rate at which fresh fuel is loaded and burned fuel is discharged is a result of the core neutronics cycle analysis but in practice (on the plant) this has to be controlled and managed by the fuel handling and storage system and use of the burnup measurement system. The excess reactivity is the additional reactivity available in the core during operating conditions that is the result of loading a fuel mixture in the core that is more reactive (less burned) than what is required to keep the reactor critical at full power operational conditions. The excess reactivity is balanced by the insertion of the control rods to keep the reactor critical. The excess reactivity allows flexibility in operations, for example to overcome the xenon build up when power is decreased as part of load follow. In order to limit reactivity excursions and to ensure safe shutdown the excess reactivity and thus the insertion depth of the control rods at normal operating conditions has to be managed. One way to do this is by operational procedures. The reactivity effect of long-term operation with the control rods inserted deeper than the design point is investigated and a control rod insertion limit is proposed that will not limit normal operations. The effects of other phenomena that can increase the power defect, such as higher-than-expected fuel temperatures, are also introduced. All of these cases are then evaluated by ensuring cold shutdown is still achievable and where appropriate by reactivity insertion accident analysis. These aspects are investigated on the PBMR 400 MW design.

  11. Glass Fiber Post/Composite Core Systems Bonded to Human Dentin: Analysis of Tensile Load vs Calculated Tensile Strength of Various Systems Using Pull-out Tests.

    Science.gov (United States)

    Keul, Christine; Köhler, Patrick; Hampe, Rüdiger; Roos, Malgorzata; Stawarczyk, Bogna

    Pull-out testing was used to determine the tensile load (TL) and tensile strength (TS) of five different fiber post systems bonded to human intracanal dentin. 120 caries-free premolars, canines, and maxillary central incisors were divided into 5 different groups for 5 fiber post systems (n = 24): 1. RelyX Fiber Post 3D (RX3D); 2. RelyX Fiber Post (RX); 3. Luxa- Post (LP); 4. FibreKleer 4X Tapered Post (FK); 5. ParaPost Taper Lux (PP). The teeth were prepared and posts inserted. Core buildups were performed with the corresponding product's resin composite. All specimens were stored in water for 24 h at 37°C. TL and TS were tested on half of the specimens (n = 12/group). The remaining samples were thermocycled (10,000 x 5°C/55°C) before testing. TL was directly measured and TS was calculated using the bonding surface. Failure modes were identified using a stereomicroscope. Data were analyzed using twoway ANOVA with the post-hoc Scheffé test, as well as the chi-squared test (p core buildup from the tooth; all other systems mainly demonstrated detachment of the core from the posts. PP, RX, and RX3D together with an adhesive core buildup yielded the highest bond strength to human dentin. Parameters TL and TS showed the same tendencies and statistical evidence.

  12. D, L-Sulforaphane Loaded Fe3O4@ Gold Core Shell Nanoparticles: A Potential Sulforaphane Delivery System.

    Science.gov (United States)

    Kheiri Manjili, Hamidreza; Ma'mani, Leila; Tavaddod, Sharareh; Mashhadikhan, Maedeh; Shafiee, Abbas; Naderi-Manesh, Hossein

    2016-01-01

    A novel design of gold-coated iron oxide nanoparticles was fabricated as a potential delivery system to improve the efficiency and stability of d, l-sulforaphane as an anticancer drug. To this purpose, the surface of gold-coated iron oxide nanoparticles was modified for sulforaphane delivery via furnishing its surface with thiolated polyethylene glycol-folic acid and thiolated polyethylene glycol-FITC. The synthesized nanoparticles were characterized by different techniques such as FTIR, energy dispersive X-ray spectroscopy, UV-visible spectroscopy, scanning and transmission electron microscopy. The average diameters of the synthesized nanoparticles before and after sulforaphane loading were obtained ∼ 33 nm and ∼ 38 nm, respectively, when ∼ 2.8 mmol/g of sulforaphane was loaded. The result of cell viability assay which was confirmed by apoptosis assay on the human breast cancer cells (MCF-7 line) as a model of in vitro-cancerous cells, proved that the bare nanoparticles showed little inherent cytotoxicity, whereas the sulforaphane-loaded nanoparticles were cytotoxic. The expression rate of the anti-apoptotic genes (bcl-2 and bcl-xL), and the pro-apoptotic genes (bax and bak) were quantified, and it was found that the expression rate of bcl-2 and bcl-xL genes significantly were decreased when MCF-7 cells were incubated by sulforaphane-loaded nanoparticles. The sulforaphane-loaded into the designed gold-coated iron oxide nanoparticles, acceptably induced apoptosis in MCF-7 cells.

  13. D, L-Sulforaphane Loaded Fe3O4@ Gold Core Shell Nanoparticles: A Potential Sulforaphane Delivery System.

    Directory of Open Access Journals (Sweden)

    Hamidreza Kheiri Manjili

    Full Text Available A novel design of gold-coated iron oxide nanoparticles was fabricated as a potential delivery system to improve the efficiency and stability of d, l-sulforaphane as an anticancer drug. To this purpose, the surface of gold-coated iron oxide nanoparticles was modified for sulforaphane delivery via furnishing its surface with thiolated polyethylene glycol-folic acid and thiolated polyethylene glycol-FITC. The synthesized nanoparticles were characterized by different techniques such as FTIR, energy dispersive X-ray spectroscopy, UV-visible spectroscopy, scanning and transmission electron microscopy. The average diameters of the synthesized nanoparticles before and after sulforaphane loading were obtained ∼ 33 nm and ∼ 38 nm, respectively, when ∼ 2.8 mmol/g of sulforaphane was loaded. The result of cell viability assay which was confirmed by apoptosis assay on the human breast cancer cells (MCF-7 line as a model of in vitro-cancerous cells, proved that the bare nanoparticles showed little inherent cytotoxicity, whereas the sulforaphane-loaded nanoparticles were cytotoxic. The expression rate of the anti-apoptotic genes (bcl-2 and bcl-xL, and the pro-apoptotic genes (bax and bak were quantified, and it was found that the expression rate of bcl-2 and bcl-xL genes significantly were decreased when MCF-7 cells were incubated by sulforaphane-loaded nanoparticles. The sulforaphane-loaded into the designed gold-coated iron oxide nanoparticles, acceptably induced apoptosis in MCF-7 cells.

  14. Multi-Core Parallel Gradual Pattern Mining Based on Multi-Precision Fuzzy Orderings

    Directory of Open Access Journals (Sweden)

    Federico Del Razo Lopez

    2013-11-01

    Full Text Available Gradual patterns aim at describing co-variations of data such as the higher the size, the higher the weight. In recent years, such patterns have been studied more and more from the data mining point of view. The extraction of such patterns relies on efficient and smart orderings that can be built among data, for instance, when ordering the data with respect to the size, then the data are also ordered with respect to the weight. However, in many application domains, it is hardly possible to consider that data values are crisply ordered. When considering gene expression, it is not true from the biological point of view that Gene 1 is more expressed than Gene 2, if the levels of expression only differ from the tenth decimal. We thus consider fuzzy orderings and fuzzy gamma rank correlation. In this paper, we address two major problems related to this framework: (i the high memory consumption and (ii the precision, representation and efficient storage of the fuzzy concordance degrees versus the loss or gain of computing power. For this purpose, we consider multi-precision matrices represented using sparse matrices coupled with parallel algorithms. Experimental results show the interest of our proposal.

  15. Response of Honeycomb Core Sandwich Panel with Minimum Gage GFRP Face-Sheets to Compression Loading After Impact

    Science.gov (United States)

    McQuigg, Thomas D.; Kapania, Rakesh K.; Scotti, Stephen J.; Walker, Sandra P.

    2011-01-01

    A compression after impact study has been conducted to determine the residual strength of three sandwich panel constructions with two types of thin glass fiber reinforced polymer face-sheets and two hexagonal honeycomb Nomex core densities. Impact testing is conducted to first determine the characteristics of damage resulting from various impact energy levels. Two modes of failure are found during compression after impact tests with the density of the core precipitating the failure mode present for a given specimen. A finite element analysis is presented for prediction of the residual compressive strength of the impacted specimens. The analysis includes progressive damage modeling in the face-sheets. Preliminary analysis results were similar to the experimental results; however, a higher fidelity core material model is expected to improve the correlation.

  16. Investigating Theoretical PV Energy Generation Patterns with Their Relation to the Power Load Curve in Poland

    Directory of Open Access Journals (Sweden)

    Jakub Jurasz

    2016-01-01

    Full Text Available Polish energy sector is (almost from its origin dominated by fossil fuel feed power. This situation results from an abundance of relatively cheap coal (hard and lignite. Brown coal due to its nature is the cheapest energy source in Poland. However, hard coal which fuels 60% of polish power plants is picking up on prices and is susceptible to the coal imported from neighboring countries. Forced by the European Union (EU regulations, Poland is struggling at achieving its goal of reaching 15% of energy consumption from renewable energy sources (RES by 2020. Over the year 2015, RES covered 11.3% of gross energy consumption but this generation was dominated by solid biomass (over 80%. The aim of this paper was to answer the following research questions: What is the relation of irradiation values to the power load on a yearly and daily basis? and how should photovoltaics (PV be integrated in the polish power system? Conducted analysis allowed us to state that there exists a negative correlation between power demand and irradiation values on a yearly basis, but this is likely to change in the future. Secondly, on average, daily values of irradiation tend to follow power load curve over the first hours of the day.

  17. Alignment of human cardiomyocytes on laser patterned biphasic core/shell nanowire assemblies

    Science.gov (United States)

    Kiefer, Karin; Lee, Juseok; Haidar, Ayman; Martinez Miró, Marina; Akkan, Cagri Kaan; Veith, Michael; Cenk Aktas, Oral; Abdul-Khaliq, Hashim

    2014-12-01

    The management of end stage heart failure patients is only possible by heart transplantation or by the implantation of artificial hearts as a bridge for later transplantation. However, these therapeutic strategies are limited by a lack of donor hearts and by the associated complications, such as coagulation and infection, due to the used artificial mechanical circulatory assist devices. Therefore, new strategies for myocardial regenerative approaches are under extensive research to produce contractile myocardial tissue in the future to replace non-contractile myocardial ischemic and scarred tissue. Different approaches, such as cell transplantation, have been studied intensively. Although successful approaches have been observed, there are still limitations to the application. It is envisaged that myocardial tissue engineering can be used to help replace infarcted non-contractile tissue. The developed tissue should later mimic the aligned fibrillar structure of the extracellular matrix and provide important guidance cues for the survival, function and the needed orientation of cardiomyocytes. Nanostructured surfaces have been tested to provide a guided direction that cells can follow. In the present study, the cellular adhesion/alignment of human cardiomyocytes and the biocompatibility have been investigated after cultivation on different laser-patterned nanowires compared with unmodified nanowires. As a result, the nanostructured surfaces possessed good biocompatibility before and after laser modification. The laser-induced scalability of the pattern enabled the growth and orientation of the adhered myocardial tissue. Such approaches may be used to modify the surface of potential scaffolds to develop myocardial contractile tissue in the future.

  18. ROSA full-core and DNBR capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Gibcus, H.P.M.; Verhagen, F.C.M.; Wakker, P.H. [NRG, Arnhem (Netherlands)

    2012-11-01

    This paper presents the latest developments of the ROSA (Reloading Optimization by Simulated Annealing) code system with an emphasis on the first full-core version and the minimum DNBR (Departure from Nucleate Boiling Ratio) as a new optimization parameter. Designing the core loading pattern of nuclear power plants is becoming a more and more complex task. This task becomes even more complicated if asymmetries in the core loading pattern arise, for instance due to damaged fuel assemblies. For over almost two decades ROSA, NRG's (Nuclear Research and consultancy Group) loading pattern optimization code system for PWRs, has proven to be a valuable tool to reactor operators in accomplishing this task. To improve the use of ROSA for designing asymmetric loading patterns, NRG has developed a full-core version of ROSA besides the original quarter-core version which requires rotational symmetry in the computational domain. The extension of ROSA with DNBR as an optimization parameter is part of ROSA's continuous development. (orig.)

  19. ROSA full-core and DNBR capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Gibcus, H.P.M.; Verhagen, F.C.M.; Wakker, P.H. [NRG, Arnhem (Netherlands)

    2013-06-15

    The latest developments of the ROSA (Reloading Optimization by Simulated Annealing) code system with an emphasis on the first full-core version and the minimum DNBR (Departure from Nucleate Boiling Ratio) as a new optimization parameter are presented. Designing the core loading pattern of nuclear power plants is becoming a more and more complex task. This task becomes even more complicated if asymmetries in the core loading pattern arise, for instance due to damaged fuel assemblies. For over almost 2 decades ROSA, NRG's (Nuclear Research and consultancy Group) loading pattern optimization code system for PWRs, has proven to be a valuable tool to reactor operators in accomplishing this task. To improve the use of ROSA for designing asymmetric loading patterns, NRG has developed a full-core version of ROSA besides the original quarter-core version which requires rotational symmetry in the computational domain. The extension of ROSA with DNBR as an optimization parameter is part of ROSA's continuous development. (orig.)

  20. APPLICATION OF POLYSTYRENE FOAM CORE FUSIBLE PATTERNS IN PRODUCTION OF GAS TURBINES’ CAST PARTS

    Directory of Open Access Journals (Sweden)

    O. I. Shinsky

    2016-01-01

    Full Text Available The task of replacing the LVM dissolves polystyrene molding on models is at the present time, technologically, economically and environmentally promising from the point of view of industrial applications for gas turbine plants in Ukraine. The authors proposed and tested manufacturing process of casting ceramic molds way to remove the polystyrene model of the dissolution of her organic solvents. Kinetic parameters of the process of dissolving and removing patterns of degradation products the polystyrene in the group of solvents depending on the type and amount of polystyrene were identified. The absence of surface defects of castings, reduction of roughness, increased their accuracy class in comparison to accepted technological regulations of the process of production, which reduced the cost of machined parts and increased utilization of expensive heat-resistant alloys were produced.

  1. Association between atmospheric circulation patterns and firn-ice core records from the Inilchek glacierized area, central Tien Shan, Asia

    Science.gov (United States)

    Aizen, V.B.; Aizen, E.M.; Melack, J.M.; Kreutz, K.J.; Cecil, L.D.

    2004-01-01

    Glacioclimatological research in the central Tien Shan was performed in the summers of 1998 and 1999 on the South Inilchek Glacier at 5100-5460 m. A 14.36 m firn-ice core and snow samples were collected and used for stratigraphic, isotopic, and chemical analyses. The firn-ice core and snow records were related to snow pit measurements at an event scale and to meteorological data and synoptic indices of atmospheric circulation at annual and seasonal scales. Linear relationships between the seasonal air temperature and seasonal isotopic composition in accumulated precipitation were established. Changes in the ??18O air temperature relationship, in major ion concentration and in the ratios between chemical species, were used to identify different sources of moisture and investigate changes in atmospheric circulation patterns. Precipitation over the central Tien Shan is characterized by the lowest ionic content among the Tien Shan glaciers and indicates its mainly marine origin. In seasons of minimum precipitation, autumn and winter, water vapor was derived from the and and semiarid regions in central Eurasia and contributed annual maximal solute content to snow accumulation in Tien Shan. The lowest content of major ions was observed in spring and summer layers, which represent maximum seasonal accumulation when moisture originates over the Atlantic Ocean and Mediterranean and Black Seas. Copyright 2004 by the American Geophysical Union.

  2. The influence of fatigue loading on the quality of the cement layer and retention strength of carbon fiber post-resin composite core restorations.

    Science.gov (United States)

    Bolhuis, Peter; de Gee, Anton; Feilzer, Albert

    2005-01-01

    Clinical studies have shown that endodontically treated teeth restored with short posts or deficient ferrules show a high failure risk. This study. evaluated the influence of fatigue loading on the quality of the cement layer between prefabricated quartz coated carbon fiber posts with restricted length and the root canal wall in maxillary pre-molars. Two adhesive resin composite cements, chemical-cured Panavia 21 (Group 1) and dual-cured RelyX-ARC (Group 2), and one resin-modified glass-ionomer cement, chemical-cured RelyX (Group 3), delta were selected for this study. Post- and-core restorations were made on single-rooted human maxillary premolars from which the coronal sections were removed at the level of the proximal cemento-enamel junction (CEJ). Following endodontic treatment, a post-and-core restoration with 6-mm post length was prepared for each tooth. The posts were directly cemented into the root canal and, after applying an adhesive (Clearfil Photo Bond), they were built up with a core build-up composite (Clearfil Photo Core). For each group (n=8), half of the specimens were exposed to fatigue loading (10(6) load cycles) almost perpendicular to the axial axis (85 degrees), while the other half were used as the control. Three parallel, transverse root sections, 1.5-mm thick, were cut from each specimen at the apical, medial and coronal location. These sections were examined by Scanning Electron Microscopy (SEM) to evaluate the integrity of the cement layer, while the retention strength of the cemented post sections was determined with the push-out test. The multivariate results of MANOVA showed that the condition main effect (fatigue or control) was not significant (p=0.059); the two other main effects, type of cement and section location, were significant (p=0.001 and p=0.008). For both the push-out strength and SEM evaluation of the cement layer integrity, the results significantly improved from RelyX to RelyX-ARC to Panavia 21 and also from apical to

  3. Methotrexate diethyl ester-loaded lipid-core nanocapsules in aqueous solution increased antineoplastic effects in resistant breast cancer cell line

    Directory of Open Access Journals (Sweden)

    Yurgel VC

    2014-03-01

    Full Text Available Virginia C Yurgel,1,* Catiuscia P Oliveira,2,* Karine R Begnini,1 Eduarda Schultze,1 Helena S Thurow,1 Priscila MM Leon,1 Odir A Dellagostin,1 Vinicius F Campos,1 Ruy CR Beck,2 Silvia S Guterres,2 Tiago Collares,1 Adriana R Pohlmann,2–4 Fabiana K Seixas11Programa de Pós-Graduação em Biotecnologia (PPGB, Grupo de Pesquisa em Oncologia Celular e Molecular, Laboratório de Genômica Funcional, Biotecnologia/Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil; 2Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; 3Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; 4Centro de Nanociência e Nanotecnologia, CNANO-UFRGS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil*These authors contributed equally to this workAbstract: Breast cancer is the most frequent cancer affecting women. Methotrexate (MTX is an antimetabolic drug that remains important in the treatment of breast cancer. Its efficacy is compromised by resistance in cancer cells that occurs through a variety of mechanisms. This study evaluated apoptotic cell death and cell cycle arrest induced by an MTX derivative (MTX diethyl ester [MTX(OEt2] and MTX(OEt2-loaded lipid-core nanocapsules in two MTX-resistant breast adenocarcinoma cell lines, MCF-7 and MDA-MB-231. The formulations prepared presented adequate granulometric profile. The treatment responses were evaluated through flow cytometry. Relying on the mechanism of resistance, we observed different responses between cell lines. For MCF-7 cells, MTX(OEt2 solution and MTX(OEt2-loaded lipid-core nanocapsules presented significantly higher apoptotic rates than untreated cells and cells incubated with unloaded lipid-core nanocapsules. For MDA-MB-231

  4. Smart multifunctional core-shell nanospheres with drug and gene co-loaded for enhancing the therapeutic effect in a rat intracranial tumor model

    Science.gov (United States)

    Wang, Hanjie; Su, Wenya; Wang, Sheng; Wang, Xiaomin; Liao, Zhenyu; Kang, Chunsheng; Han, Lei; Chang, Jin; Wang, Guangxiu; Pu, Peiyu

    2012-09-01

    Glioblastoma with high mortality has been one of the most serious cancers threatening human health. Because of the present treatment limitations, there is an urgent need to construct a multifunctional vesicle for enhancing the treatment of in situ malignant glioblastoma. In our study, drug and gene co-loaded magnetic PLGA/multifunctional polymeric liposome (magnetic PLGA/MPLs) core-shell nanospheres were constructed. They were mainly self-assembled from two parts: hydrophobic PLGA cores that can load drugs and magnetic nanocrystals; and polymeric lipid shells anchored with functional molecules such as PEG chains, TAT peptides and RGD peptides that can help the vectors to condense the gene, prolong the circulation time, cross the blood brain barrier and target delivery to the cancer tissue. The results showed that the magnetic PLGA/MPLs nanosphere has a nanosized core-shell structure, can achieve sustained drug release and has good DNA binding abilities. Importantly, compared with the control group and other groups with single functionality, it can co-deliver the drug and gene into the same cell in vitro and show the strongest inhibiting effect on the growth of the in situ malignant glioblastoma in vivo. All of these results indicated that the different functional components of magnetic PLGA/MPLs, can form an organic whole and none of them can be dispensed with. The magnetic PLGA/MPLs nanosphere may be another option for treatment of glioblastoma.Glioblastoma with high mortality has been one of the most serious cancers threatening human health. Because of the present treatment limitations, there is an urgent need to construct a multifunctional vesicle for enhancing the treatment of in situ malignant glioblastoma. In our study, drug and gene co-loaded magnetic PLGA/multifunctional polymeric liposome (magnetic PLGA/MPLs) core-shell nanospheres were constructed. They were mainly self-assembled from two parts: hydrophobic PLGA cores that can load drugs and magnetic

  5. Changes in the drug release pattern of fresh and set simvastatin-loaded brushite cement.

    Science.gov (United States)

    Mestres, Gemma; Kugiejko, Karol; Pastorino, David; Unosson, Johanna; Öhman, Caroline; Karlsson Ott, Marjam; Ginebra, Maria-Pau; Persson, Cecilia

    2016-01-01

    Calcium phosphate cements are synthetic bone graft substitutes able to set at physiological conditions. They can be applied by minimally invasive surgery and can also be used as drug delivery systems. Consequently, the drug release pattern from the cement paste (fresh cement) is of high clinical interest. However, previous studies have commonly evaluated the drug release using pre-set cements only. Therefore, the aim of this work was to determine if the time elapsed from cement preparation until immersion in the solution (3 min for fresh cements, and 1h and 15 h for pre-set cements) had an influence on its physical properties, and correlating these to the drug release profile. Simvastatin was selected as a model drug, while brushite cement was used as drug carrier. This study quantified how the setting of a material reduces the accessibility of the release media to the material, thus preventing drug release. A shift in the drug release pattern was observed, from a burst-release for fresh cements to a sustained release for pre-set cements.

  6. Exercise Alters Gait Pattern but Not Knee Load in Patients with Knee Osteoarthritis

    Science.gov (United States)

    Lin, Yi-Jia; Chang, Chao-Chin; Chou, You-Cai

    2016-01-01

    Six female patients with bilateral medial knee OA and 6 healthy controls were recruited. Patients with knee OA received a 6-week physiotherapist-supervised and home-based exercise program. Outcome measures, including the Western Ontario and McMaster Universities Arthritis Index and Short Form-36 Health Survey as well as objective biomechanical indices were obtained at baseline and follow-up. After treatment, no significant difference was observed in the knee abductor moment (KAM), lever arm, and ground reaction force. We, however, observed significantly improved pain and physical function as well as altered gait patterns, including a higher hip flexor moment and hip extension angle with a faster walking speed. Although KAM was unchanged, patients with bilateral knee OA showed an improved walking speed and altered the gait pattern after 6 weeks of supervised exercise. This finding suggests that the exercise intervention improves proximal joint mechanics during walking and can be considered for patients with bilateral knee OA. Non-weight-bearing strengthening without external resistance combined with stretching exercise may be an option to improve pain and function in individuals with OA who cannot perform high resistance exercises owing to pain or other reasons. PMID:27725941

  7. Exercise Alters Gait Pattern but Not Knee Load in Patients with Knee Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Ssu-Yu Chang

    2016-01-01

    Full Text Available Six female patients with bilateral medial knee OA and 6 healthy controls were recruited. Patients with knee OA received a 6-week physiotherapist-supervised and home-based exercise program. Outcome measures, including the Western Ontario and McMaster Universities Arthritis Index and Short Form-36 Health Survey as well as objective biomechanical indices were obtained at baseline and follow-up. After treatment, no significant difference was observed in the knee abductor moment (KAM, lever arm, and ground reaction force. We, however, observed significantly improved pain and physical function as well as altered gait patterns, including a higher hip flexor moment and hip extension angle with a faster walking speed. Although KAM was unchanged, patients with bilateral knee OA showed an improved walking speed and altered the gait pattern after 6 weeks of supervised exercise. This finding suggests that the exercise intervention improves proximal joint mechanics during walking and can be considered for patients with bilateral knee OA. Non-weight-bearing strengthening without external resistance combined with stretching exercise may be an option to improve pain and function in individuals with OA who cannot perform high resistance exercises owing to pain or other reasons.

  8. Is Lumbo-Sacral Angle Related to Plantar Loading Patterns in Patients with Ankylosing Spondylitis?

    Directory of Open Access Journals (Sweden)

    Elif Aydın

    2016-08-01

    Full Text Available Objective: Loss of lumbar lordosis is a clinical feature of ankylosing spondylitis (AS. Pedobarographic analysis assesses the interaction between the foot and the supporting surface. Postural abnormalities can reflect as pressure distribution deviations on pedobarography. The objective of the present study was to assess whether loss of lumbar lordosis detected with lumbo-sacral angle measurement is related to postural control assessed by plantar loading distribution in patients with AS. Materials and Methods: Thirty-two patients (two female, 30 male, mean age: 43.06±7.8 years with the diagnosis of AS, who already had a lateral lumbo-sacral X-ray performed within the past one year, were included in the study. Static and dynamic pedobarographic analyses of the patients were performed. The radiographic measurement of lumbo-sacral angle was done from lateral lumbo-sacral X-rays of the patients. Results: The static pedobarographic measurement revealed that lumbo-sacral angle was significantly correlated with forefoot plantar pressure (p=0.042; r=0.361. In the dynamic assessment, the maximum pressures were lower under the first metatarsal area in patients with lower lumbo-sacral angle (p=0.352; r=0.048. Conclusion: These findings suggest that foot joints may contribute to the compensation mechanism against the postural changes in patients with AS, statically and dynamically.

  9. AN EXPLORATORY ANALYSIS ON HALF-HOURLY ELECTRICITY LOAD PATTERNS LEADING TO HIGHER PERFORMANCES IN NEU

    Directory of Open Access Journals (Sweden)

    K.A.D. Deshani

    2014-05-01

    Full Text Available Accurate prediction of electricity demand can bring extensive benefits to any country as the forecasted values help the relevant authorities to take decisions regarding electricity generation, transmission and distribution appropriately. The literature reveals that, when compared to conventional time series techniques, the improved artificial intelligent approaches provide better prediction accuracies. However, the accuracy of predictions using intelligent approaches like neural networks are strongly influenced by the correct selection of inputs and the number of neuro-forecasters used for prediction. Deshani, Hansen, Attygalle, & Karunarathne (2014 suggested that a cluster analysis could be performed to group similar day types, which contribute towards selecting a better set of neuro-forecasters in neural networks. The cluster analysis was based on the daily total electricity demands as their target was to predict the daily total demands using neural networks. However, predicting half-hourly demand seems more appropriate due to the considerable changes of electricity demand observed during a particular day. As such clusters are identified considering half-hourly data within the daily load distribution curves. Thus, this paper is an improvement to Deshani et. al. (2014, which illustrates how the half hourly demand distribution within a day, is incorporated when selecting the inputs for the neuro-forecasters.

  10. Levels and patterns of HIV RNA viral load in untreated pregnant women

    DEFF Research Database (Denmark)

    NN, NN; Patel, Deven; Thorne, Claire;

    2008-01-01

    OBJECTIVE: To assess pregnancy levels and patterns of HIV RNA in the absence of antiretroviral therapy, while appropriately adjusting for potential confounders, including maternal immune status and race. METHODS: Data on > or = 1 antenatal HIV RNA measurements were available for 333 untreated HIV......-infected pregnant women enrolled in the European Collaborative Study. CD4 counts and HIV RNA measurements were routinely collected from 1992 and 1998, respectively. Linear mixed effects models based on 246 women for whom complete data were available examined changes in HIV RNA levels over pregnancy, with a nested...... random effects term accounting for measurement variability within women and period of sample collection. RESULTS: The change in HIV RNA over pregnancy varied significantly by race (p=0.005): from the second trimester until delivery, HIV RNA decreased significantly by an estimated 0.019 log(10) copies...

  11. Spatial and temporal patterns of turbidity, sediment concentration and load across nested scales in an urban watershed

    Science.gov (United States)

    Kemper, J. T.; Welty, C.; Miller, A. J.

    2016-12-01

    In a highly regulated area such as the Chesapeake Bay watershed, suspended sediment is a matter of primary concern. However, there are few continuous sediment-concentration records available to quantify urban sediment loads. Near real-time turbidity and discharge data have been collected continuously for more than three years at six stream gages representing three nested watershed scales (1-2 sq km, 5-6 sq km, 14 sq km) in the highly impervious Dead Run watershed, located in Baltimore County, MD. Suspended sediment point samples have been collected for multiple storm events at five of the six sites, to establish provisional relationships between turbidity and suspended sediment concentrations. Using these calculated relationships and USGS discharge data, we can quantify sediment loads at each station. Turbidity-discharge relationships vary both spatially and temporally, highlighting the extreme heterogeneity of an urban watershed. Spatially, relationships change from headwaters to mouth, potentially suggesting a variation in sediment sources. Temporally, relationships change both seasonally and annually. The lowest turbidity values are consistently seen in the fall, while values in winter, spring, and summer display a high inter-annual variability. Sediment loads and yields calculated for four representative storms are compared across nested watershed scales to assess evidence for sources or sinks at different locations within the drainage network. Yields at the mouth of the watershed (DRKR) for large storms were higher than an area-weighted average of the two contributing sites (DR3, DR4), potentially suggesting additional source areas of sediment within the watershed. This highlights the ability of near real-time data to assist in developing more effective approaches in mitigating sediment transport by helping to identifying consistent trends, locations of hot spots, and patterns of sediment arrival.

  12. Effects of Two Types of Melatonin-Loaded Nanocapsules with Distinct Supramolecular Structures: Polymeric (NC and Lipid-Core Nanocapsules (LNC on Bovine Embryo Culture Model.

    Directory of Open Access Journals (Sweden)

    Eliza Rossi Komninou

    Full Text Available Melatonin has been used as a supplement in culture medium to improve the efficiency of in vitro produced mammalian embryos. Through its ability to scavenge toxic oxygen derivatives and regulate cellular mRNA levels for antioxidant enzymes, this molecule has been shown to play a protective role against damage by free radicals, to which in vitro cultured embryos are exposed during early development. In vivo and in vitro studies have been performed showing that the use of nanocapsules as active substances carriers increases stability, bioavailability and biodistribution of drugs, such as melatonin, to the cells and tissues, improving their antioxidant properties. These properties can be modulated through the manipulation of formula composition, especially in relation to the supramolecular structures of the nanocapsule core and the surface area that greatly influences drug release mechanisms in biological environments. This study aimed to evaluate the effects of two types of melatonin-loaded nanocapsules with distinct supramolecular structures, polymeric (NC and lipid-core (LNC nanocapsules, on in vitro cultured bovine embryos. Embryonic development, apoptosis, reactive oxygen species (ROS production, and mRNA levels of genes involved in cell apoptosis, ROS and cell pluripotency were evaluated after supplementation of culture medium with non-encapsulated melatonin (Mel, melatonin-loaded polymeric nanocapsules (Mel-NC and melatonin-loaded lipid-core nanocapsules (Mel-LNC at 10-6, 10-9, and 10-12 M drug concentrations. The highest hatching rate was observed in embryos treated with 10-9 M Mel-LNC. When compared to Mel and Mel-NC treatments at the same concentration (10-9 M, Mel-LNC increased embryo cell number, decreased cell apoptosis and ROS levels, down-regulated mRNA levels of BAX, CASP3, and SHC1 genes, and up-regulated mRNA levels of CAT and SOD2 genes. These findings indicate that nanoencapsulation with LNC increases the protective effects of

  13. Effects of Two Types of Melatonin-Loaded Nanocapsules with Distinct Supramolecular Structures: Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on Bovine Embryo Culture Model

    Science.gov (United States)

    Komninou, Eliza Rossi; Remião, Mariana Härter; Lucas, Caroline Gomes; Domingues, William Borges; Basso, Andrea Cristina; Jornada, Denise Soledade; Deschamps, João Carlos; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin; Bordignon, Vilceu; Seixas, Fabiana Kömmling; Campos, Vinicius Farias; Guterres, Silvia Stanisçuaski; Collares, Tiago

    2016-01-01

    Melatonin has been used as a supplement in culture medium to improve the efficiency of in vitro produced mammalian embryos. Through its ability to scavenge toxic oxygen derivatives and regulate cellular mRNA levels for antioxidant enzymes, this molecule has been shown to play a protective role against damage by free radicals, to which in vitro cultured embryos are exposed during early development. In vivo and in vitro studies have been performed showing that the use of nanocapsules as active substances carriers increases stability, bioavailability and biodistribution of drugs, such as melatonin, to the cells and tissues, improving their antioxidant properties. These properties can be modulated through the manipulation of formula composition, especially in relation to the supramolecular structures of the nanocapsule core and the surface area that greatly influences drug release mechanisms in biological environments. This study aimed to evaluate the effects of two types of melatonin-loaded nanocapsules with distinct supramolecular structures, polymeric (NC) and lipid-core (LNC) nanocapsules, on in vitro cultured bovine embryos. Embryonic development, apoptosis, reactive oxygen species (ROS) production, and mRNA levels of genes involved in cell apoptosis, ROS and cell pluripotency were evaluated after supplementation of culture medium with non-encapsulated melatonin (Mel), melatonin-loaded polymeric nanocapsules (Mel-NC) and melatonin-loaded lipid-core nanocapsules (Mel-LNC) at 10−6, 10−9, and 10−12 M drug concentrations. The highest hatching rate was observed in embryos treated with 10−9 M Mel-LNC. When compared to Mel and Mel-NC treatments at the same concentration (10−9 M), Mel-LNC increased embryo cell number, decreased cell apoptosis and ROS levels, down-regulated mRNA levels of BAX, CASP3, and SHC1 genes, and up-regulated mRNA levels of CAT and SOD2 genes. These findings indicate that nanoencapsulation with LNC increases the protective effects of

  14. Effects of Two Types of Melatonin-Loaded Nanocapsules with Distinct Supramolecular Structures: Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on Bovine Embryo Culture Model.

    Science.gov (United States)

    Komninou, Eliza Rossi; Remião, Mariana Härter; Lucas, Caroline Gomes; Domingues, William Borges; Basso, Andrea Cristina; Jornada, Denise Soledade; Deschamps, João Carlos; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin; Bordignon, Vilceu; Seixas, Fabiana Kömmling; Campos, Vinicius Farias; Guterres, Silvia Stanisçuaski; Collares, Tiago

    2016-01-01

    Melatonin has been used as a supplement in culture medium to improve the efficiency of in vitro produced mammalian embryos. Through its ability to scavenge toxic oxygen derivatives and regulate cellular mRNA levels for antioxidant enzymes, this molecule has been shown to play a protective role against damage by free radicals, to which in vitro cultured embryos are exposed during early development. In vivo and in vitro studies have been performed showing that the use of nanocapsules as active substances carriers increases stability, bioavailability and biodistribution of drugs, such as melatonin, to the cells and tissues, improving their antioxidant properties. These properties can be modulated through the manipulation of formula composition, especially in relation to the supramolecular structures of the nanocapsule core and the surface area that greatly influences drug release mechanisms in biological environments. This study aimed to evaluate the effects of two types of melatonin-loaded nanocapsules with distinct supramolecular structures, polymeric (NC) and lipid-core (LNC) nanocapsules, on in vitro cultured bovine embryos. Embryonic development, apoptosis, reactive oxygen species (ROS) production, and mRNA levels of genes involved in cell apoptosis, ROS and cell pluripotency were evaluated after supplementation of culture medium with non-encapsulated melatonin (Mel), melatonin-loaded polymeric nanocapsules (Mel-NC) and melatonin-loaded lipid-core nanocapsules (Mel-LNC) at 10-6, 10-9, and 10-12 M drug concentrations. The highest hatching rate was observed in embryos treated with 10-9 M Mel-LNC. When compared to Mel and Mel-NC treatments at the same concentration (10-9 M), Mel-LNC increased embryo cell number, decreased cell apoptosis and ROS levels, down-regulated mRNA levels of BAX, CASP3, and SHC1 genes, and up-regulated mRNA levels of CAT and SOD2 genes. These findings indicate that nanoencapsulation with LNC increases the protective effects of melatonin

  15. Water consumption patterns in rural Bangladesh: are we underestimating total arsenic load?

    Science.gov (United States)

    Milton, Abul Hasnat; Rahman, Habibur; Smith, Wayne; Shrestha, Rupendra; Dear, Keith

    2006-12-01

    Risk related to the ingestion of any water contaminants depends on many factors, including the daily per capita amount of consumed water relative to body weight. This study explored the water consumption pattern of a rural arsenic-affected population in Bangladesh. The study findings are likely to contribute to the risk estimation attributable to ingestion of arsenic and other drinking water contaminants. A total of 640 individuals participated in this cross-sectional study carried out in an arsenic-affected rural population in Bangladesh. In this study daily per capita water consumption for drinking purposes was found to be 73.04 ml/kg/d (range = 71.24-74.84 ml/kg/d), which is higher than for both the US and Taiwan populations. This difference in per capita drinking water consumption might contribute to much higher lifetime cancer mortality and other morbidity risks from arsenic among the Bangladesh population compared to either the US or Taiwan populations. Arsenic is also ingested through cooking water which, if considered, might increase the risk further. The findings of this study highlight the urgent need for a holistic water supply programme for Bangladesh, with special emphasis on the arsenic-affected population.

  16. Evaluation of Effect of Fuel Assembly Loading Patterns on Thermal and Shielding Performance of a Spent Fuel Storage/Transportation Cask

    Energy Technology Data Exchange (ETDEWEB)

    Cuta, Judith M.; Jenquin, Urban P.; McKinnon, Mikal A.

    2001-11-20

    The licensing of spent fuel storage casks is generally based on conservative analyses that assume a storage system being uniformly loaded with design basis fuel. The design basis fuel typically assumes a maximum assembly enrichment, maximum burn up, and minimum cooling time. These conditions set the maximum decay heat loads and radioactive source terms for the design. Recognizing that reactor spent fuel pools hold spent fuel with an array of initial enrichments, burners, and cooling times, this study was performed to evaluate the effect of load pattern on peak cladding temperature and cask surface dose rate. Based on the analysis, the authors concluded that load patterns could be used to reduce peak cladding temperatures in a cask without adversely impacting the surface dose rates.

  17. Comparable cerebral oxygenation patterns in younger and older adults during dual-task walking with increasing load

    Directory of Open Access Journals (Sweden)

    Sarah A. Fraser

    2016-10-01

    Full Text Available The neuroimaging literature on dual-task gait clearly demonstrates increased prefrontal cortex (PFC involvement when performing a cognitive task while walking. However, findings from direct comparisons of the cerebral oxygenation patterns of younger (YA and older (OA adults during dual-task walking are mixed and it is unclear how YA and OA respond to increasing cognitive load (difficulty while walking. This functional near infra-red (fNIRS study examined cerebral oxygenation of YA and OA during self-paced dual-task treadmill walking at two different levels of cognitive load (auditory n-back. Changes in accuracy (% as well as oxygenated (HbO and deoxygenated (HbR hemoglobin were examined. For the HbO and HbR measures, eight regions of interest (ROIs were assessed: the anterior and posterior dorsolateral and ventrolateral PFC (aDLPFC, pDLPFC, aVLPFC, pVLPFC in each hemisphere. Nineteen YA (M = 21.83 yrs and 14 OA (M = 66.85 yrs walked at a self-selected pace while performing auditory 1-back and 2-back tasks. Walking alone (single motor: SM and performing the cognitive tasks alone (single cognitive: SC were compared to dual-task walking (DT = SM + SC. In the behavioural data, participants were more accurate in the lowest level of load (1-back compared to the highest (2-back; p ˂ .001. YA were more accurate than OA overall (p = .009, and particularly in the 2-back task (p = .048. In the fNIRS data, both younger and older adults had task effects (SM < DT in specific ROIs for ∆HbO (3 YA, 1 OA and ∆HbR (7 YA, 8 OA. After controlling for walk speed differences, direct comparisons between YA and OA did not reveal significant age differences, but did reveal a difficulty effect in HbO in the left aDLPFC (p = .028 and significant task effects (SM < DT in HbR for 6 of the 8 ROIs. Findings suggest that YA and OA respond similarly to manipulations of cognitive load when walking on a treadmill at a self-selected pace.

  18. The effect of fibre layering pattern in resisting bending loads of natural fibre-based hybrid composite materials

    Directory of Open Access Journals (Sweden)

    Jusoh Muhamad Shahirul Mat

    2016-01-01

    Full Text Available The effect of fibre layering pattern and hybridization on the flexural properties of composite hybrid laminates between natural fibres of basalt, jute and flax with synthetic fibre of E-glass reinforced epoxy have been investigated experimentally. Results showed that the effect fibre layering pattern was highly significant on the flexural strength and modulus, which were strongly dependent on the hybrid configuration between sandwich-like (SL and intercalation (IC sequence of fibre layers. In addition, specific modulus based on the variation densities of the hybrid laminates was used to discover the best combination either basalt, jute or flax with E-glass exhibits superior properties concerning on the strength to weight-ratio. Generally, SL sequence of glass/basalt exhibited superior strength and stiffness compared with glass/jute and glass/flax in resisting bending loads. In terms of hybridization effect, glass/jute was found to be the best combination with E-glass compared to the rest of natural fibres investigated in the present study. Hence, the proper stacking sequences and material selection are among predominant factors that influence on mechanical properties and very crucial in designing composite hybrid system to meet the desired requirements.

  19. Parcellation of Human and Monkey Core Auditory Cortex with fMRI Pattern Classification and Objective Detection of Tonotopic Gradient Reversals.

    Science.gov (United States)

    Schönwiesner, Marc; Dechent, Peter; Voit, Dirk; Petkov, Christopher I; Krumbholz, Katrin

    2015-10-01

    Auditory cortex (AC) contains several primary-like, or "core," fields, which receive thalamic input and project to non-primary "belt" fields. In humans, the organization and layout of core and belt auditory fields are still poorly understood, and most auditory neuroimaging studies rely on macroanatomical criteria, rather than functional localization of distinct fields. A myeloarchitectonic method has been suggested recently for distinguishing between core and belt fields in humans (Dick F, Tierney AT, Lutti A, Josephs O, Sereno MI, Weiskopf N. 2012. In vivo functional and myeloarchitectonic mapping of human primary auditory areas. J Neurosci. 32:16095-16105). We propose a marker for core AC based directly on functional magnetic resonance imaging (fMRI) data and pattern classification. We show that a portion of AC in Heschl's gyrus classifies sound frequency more accurately than other regions in AC. Using fMRI data from macaques, we validate that the region where frequency classification performance is significantly above chance overlaps core auditory fields, predominantly A1. Within this region, we measure tonotopic gradients and estimate the locations of the human homologues of the core auditory subfields A1 and R. Our results provide a functional rather than anatomical localizer for core AC. We posit that inter-individual variability in the layout of core AC might explain disagreements between results from previous neuroimaging and cytological studies.

  20. Effect of core body temperature, time of day, and climate conditions on behavioral patterns of lactating dairy cows experiencing mild to moderate heat stress.

    Science.gov (United States)

    Allen, J D; Hall, L W; Collier, R J; Smith, J F

    2015-01-01

    Cattle show several responses to heat load, including spending more time standing. Little is known about what benefit this may provide for the animals. Data from 3 separate cooling management trials were analyzed to investigate the relationship between behavioral patterns in lactating dairy cows experiencing mild to moderate heat stress and their body temperature. Cows (n=157) were each fitted with a leg data logger that measured position and an intravaginal data logger that measures core body temperature (CBT). Ambient conditions were also collected. All data were standardized to 5-min intervals, and information was divided into several categories: when standing and lying bouts were initiated and the continuance of each bout (7,963 lying and 6,276 standing bouts). In one location, cows were continuously subjected to heat-stress levels according to temperature-humidity index (THI) range (THI≥72). The THI range for the other 2 locations was below and above a heat-stress threshold of 72 THI. Overall and regardless of period of day, cows stood up at greater CBT compared with continuing to stand or switching to a lying position. In contrast, cows lay down at lower CBT compared with continuing to lie or switching to a standing position, and lying bouts lasted longer when cows had lower CBT. Standing bouts also lasted longer when cattle had greater CBT, and they were less likely to lie down (less than 50% of lying bouts initiated) when their body temperature was over 38.8°C. Also, cow standing behavior was affected once THI reached 68. Increasing CBT decreased lying duration and increased standing duration. A CBT of 38.93°C marked a 50% likelihood a cow would be standing. This is the first physiological evidence that standing may help cool cows and provides insight into a communally observed behavioral response to heat.

  1. Fuel and Core Design Options to Overcome the Heavy Metal Loading Limit and Improve Performance and Safety of Liquid Salt Cooled Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Petrovic, Bojan [Georgia Inst. of Technology, Atlanta, GA (United States); Maldonado, Ivan [Univ. of Tennessee, Knoxville, TN (United States)

    2016-04-14

    The research performed in this project addressed the issue of low heavy metal loading and the resulting reduced cycle length with increased refueling frequency, inherent to all FHR designs with solid, non-movable fuel based on TRISO particles. Studies performed here focused on AHTR type of reactor design with plate (“plank”) fuel. Proposal to FY12 NEUP entitled “Fuel and Core Design Options to Overcome the Heavy Metal Loading Limit and Improve Performance and Safety of Liquid Salt Cooled Reactors” was selected for award, and the 3-year project started in August 2012. A 4-month NCE was granted and the project completed on December 31, 2015. The project was performed by Georgia Tech (Prof. Bojan Petrovic, PI) and University of Tennessee (Prof. Ivan Maldonado, Co-PI), with a total funding of $758,000 over 3 years. In addition to two Co-PIs, the project directly engaged 6 graduate students (at doctoral or MS level) and 2 postdoctoral researchers. Additionally, through senior design projects and graduate advanced design projects, another 23 undergraduate and 12 graduate students were exposed to and trained in the salt reactor technology. We see this as one of the important indicators of the project’s success and effectiveness. In the process, 1 journal article was published (with 3 journal articles in preparation), together with 8 peer-reviewed full conference papers, 8 peer-reviewed extended abstracts, as well as 1 doctoral dissertation and 2 master theses. The work included both development of models and methodologies needed to adequately analyze this type of reactor, fuel, and its fuel cycle, as well as extensive analyses and optimization of the fuel and core design.

  2. Frequency patterns of chitinozoans, scolecodonts, and conodonts in the upper Llandovery and lower Wenlock of the Paatsalu core, western Estonia

    Directory of Open Access Journals (Sweden)

    Nestor, Viiu

    2006-06-01

    Full Text Available Frequency patterns of chitinozoans, scolecodonts (polychaete jaws, and conodonts in the upper Llandovery and lower Wenlock of the Paatsalu core, western Estonia, are described. Chitinozoans are represented by nearly 50 species and constitute the most abundant group, outnumbering scolecodonts and conodonts by 10–100 times. Jawed polychaetes with about 60 species and up to thousands of specimens per kilogram of rock are the most diverse but least varying group. Conodonts display marked variations in abundance and relative frequency, which are partly caused by global evolutionary patterns of conodont faunas.The Llandovery Rumba Formation is characterized by large numbers of scolecodonts, common and diverse chitinozoans, and very rare conodonts. Good correlation between the abundance of microfossils and lithology in the Rumba Formation most likely indicates variations in the deposition/compaction rate. Interestingly, the lithologically sharp Rumba–Velise boundary is indistinct in chitinozoan and polychaete faunas; marked changes occur above the boundary. The Velise Formation, except its basal part, is characterized by a decreased number of scolecodonts and abundant conodonts. The changes in chitinozoan and conodont faunas at the Llandovery–Wenlock boundary are sharp, partly on account of a stratigraphical gap. The abundance of chitinozoans increases 10 times, whilst that of conodonts decreases; both groups display a significant turnover in assemblages and decrease in diversity. Changes in jawed polychaete faunas are less conspicuous, although a major change in relative frequency of dominating forms can be observed. The Wenlock Jaani Formation is characterized by maximum abundance of chitinozoans and scolecodonts, and decreased abundance and diversity of conodonts. The last group was most affected by the Ireviken Event.

  3. Synthesis of Fe3O4@phenol formaldehyde resin core-shell nanospheres loaded with Au nanoparticles as magnetic FRET nanoprobes for detection of thiols in living cells.

    Science.gov (United States)

    Yang, Ping; Xu, Qi-Zhi; Jin, Sheng-Yu; Zhao, Yang; Lu, Yang; Xu, Xue-Wei; Yu, Shu-Hong

    2012-01-23

    A magnetic, sensitive, and selective fluorescence resonance energy transfer (FRET) probe for detection of thiols in living cells was designed and prepared. The FRET probe consists of an Fe(3)O(4) core, a green-luminescent phenol formaldehyde resin (PFR) shell, and Au nanoparticles (NPs) as FRET quenching agent on the surface of the PFR shell. The Fe(3)O(4) NPs were used as the core and coated with green-luminescent PFR nanoshells by a simple hydrothermal approach. Au NPs were then loaded onto the surface of the PFR shell by electric charge absorption between Fe(3)O(4)@PFR and Au NPs after modifying the Fe(3)O(4)@PFR nanocomposites with polymers to alter the charge of the PFR shell. Thus, a FRET probe can be designed on the basis of the quenching effect of Au NPs on the fluorescence of Fe(3)O(4)@PFR nanocomposites. This magnetic and sensitive FRET probe was used to detect three kinds of primary biological thiols (glutathione, homocysteine, and cysteine) in cells. Such a multifunctional fluorescent probe shows advantages of strong magnetism for sample separation, sensitive response for sample detection, and low toxicity without injury to cellular components.

  4. Diagnose Test-Taker's Profile in Terms of Core Profile Patterns: Principal Component (PC) vs. Profile Analysis via MDS (PAMS) Approaches.

    Science.gov (United States)

    Kim, Se-Kang; Davison, Mark L.

    A study was conducted to examine how principal components analysis (PCA) and Profile Analysis via Multidimensional Scaling (PAMS) can be used to diagnose individuals observed score profiles in terms of core profile patterns identified by each method. The standardization sample from the Wechsler Intelligence Scale for Children, Third Edition…

  5. Core stability training for injury prevention.

    Science.gov (United States)

    Huxel Bliven, Kellie C; Anderson, Barton E

    2013-11-01

    Enhancing core stability through exercise is common to musculoskeletal injury prevention programs. Definitive evidence demonstrating an association between core instability and injury is lacking; however, multifaceted prevention programs including core stabilization exercises appear to be effective at reducing lower extremity injury rates. PUBMED WAS SEARCHED FOR EPIDEMIOLOGIC, BIOMECHANIC, AND CLINICAL STUDIES OF CORE STABILITY FOR INJURY PREVENTION (KEYWORDS: "core OR trunk" AND "training OR prevention OR exercise OR rehabilitation" AND "risk OR prevalence") published between January 1980 and October 2012. Articles with relevance to core stability risk factors, assessment, and training were reviewed. Relevant sources from articles were also retrieved and reviewed. Stabilizer, mobilizer, and load transfer core muscles assist in understanding injury risk, assessing core muscle function, and developing injury prevention programs. Moderate evidence of alterations in core muscle recruitment and injury risk exists. Assessment tools to identify deficits in volitional muscle contraction, isometric muscle endurance, stabilization, and movement patterns are available. Exercise programs to improve core stability should focus on muscle activation, neuromuscular control, static stabilization, and dynamic stability. Core stabilization relies on instantaneous integration among passive, active, and neural control subsystems. Core muscles are often categorized functionally on the basis of stabilizing or mobilizing roles. Neuromuscular control is critical in coordinating this complex system for dynamic stabilization. Comprehensive assessment and training require a multifaceted approach to address core muscle strength, endurance, and recruitment requirements for functional demands associated with daily activities, exercise, and sport.

  6. Core-shell hybrid liposomal vesicles loaded with panax notoginsenoside: preparation, characterization and protective effects on global cerebral ischemia/reperfusion injury and acute myocardial ischemia in rats

    Directory of Open Access Journals (Sweden)

    Zhang J

    2012-08-01

    Full Text Available Jing Zhang,1,* Xizhen Han,1,* Xiang Li,2 Yun Luo,1 Haiping Zhao,1 Ming Yang,1 Bin Ni,1 Zhenggen Liao11Key Laboratory of Modern Preparation of TCM, Ministry of Education, 2National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, People's Republic of China*These authors contributed equally to this workPurpose: Novel panax notoginsenoside-loaded core-shell hybrid liposomal vesicles (PNS-HLV were developed to resolve the restricted bioavailability of PNS and to enhance its protective effects in vivo on oral administration.Methods: Physicochemical characterizations of PNS-HLV included assessment of morphology, particle size and zeta potential, encapsulation efficiency (EE%, stability and in vitro release study. In addition, to evaluate its oral treatment potential, we compared the effect of PNS-HLV on global cerebral ischemia/reperfusion and acute myocardial ischemia injury with those of PNS solution, conventional PNS-loaded nanoparticles, and liposomes.Results: In comparison with PNS solution, conventional PNS-loaded nanoparticles and liposomes, PNS-HLV was stable for at least 12 months at 4°C. Satisfactory improvements in the EE% of notoginsenoside R1, ginsenoside Rb1, and ginsenoside Rg1 were shown with the differences in EE% shortened and the greater controlled drug release profiles were exhibited from PNS-HLV. The improvements in the physicochemical properties of HLV contributed to the results that PNS-HLV was able to significantly inhibit the edema of brain and reduce the infarct volume, while it could markedly inhibit H2O2, modified Dixon agar, and serum lactate dehydrogenase, and increase superoxide dismutase (P < 0.05.Conclusion: The results of the present study imply that HLV has promising prospects for improving free drug bioactivity on oral administration.Keywords: liposomes, nanoparticles, panax notoginsenoside, physicochemical properties

  7. Pattern of aerosol mass loading and chemical composition over the atmospheric environment of an urban coastal station

    Science.gov (United States)

    Bindu, G.; Nair, Prabha R.; Aryasree, S.; Hegde, Prashant; Jacob, Salu

    2016-02-01

    Aerosol sampling was carried out at four locations in and around Cochin (9°58‧ N, 76°17‧ E), an urban area, located on the southwest coast of India. The gravimetric estimates of aerosol mass loading showed wide range from 78 μg m-3 to >450 μg m-3, occasionally reaching values >500 μg m-3, associated with regional source characteristics. Most of the values were above the air quality standard. Both boundary layer and synoptic scale airflow pattern play role in the temporal features in aerosol mass loading and chemical composition. Chemical analysis of the aerosol samples were done for anionic species viz; F-, Cl-, Br-, NO2-,   NO3-,   PO43-,   SO42- and metallic/cationic species viz; Na, Ca, K, Mg, NH4+, Fe, Al, Cu, Mg, Pb, etc using Ion Chromatography, Atomic Absorption Spectroscopy (AAS) and Inductively Coupled Plasma- Atomic Emission Spectroscopy (ICP-AES). At all the locations, extremely high mass concentration of SO42- was observed with the mean value of 13±6.4 μg m-3 indicating the strong anthropogenic influence. Statistical analysis of the chemical composition data was carried out and the principal factors presented. Seasonal variation of these chemical species along with their percentage contributions and regional variations were also examined. Increase in level of Na in aerosol samples indicated the influence of monsoonal activity. Most of the species showed mass concentrations well above those measured over another coastal site Thiruvananthapuram (8°29‧ N, 76°57‧ E) situated ~220 km south of Cochin revealing the highly localized aerosol features.

  8. Exercises for the torso performed in a standing posture: spine and hip motion and motor patterns and spine load.

    Science.gov (United States)

    McGill, Stuart M; Karpowicz, Amy; Fenwick, Chad M J; Brown, Stephen H M

    2009-03-01

    The purpose of this study was to document the muscle activity, spine motion, spine load, and stiffness during several movement-based or "functional" exercises and to assess the effect of technique change. Eight subjects, all healthy men from a university population, were instrumented to obtain surface electromyography of selected trunk and hip muscles, together with video analysis and electromagnetic lumbar spine position sensor to track spine posture. Exercises included a walkout in the sagittal plane that compared an upright form against a wall with those performed on the floor, overhead cable pushes, lateral cable walkouts, the good morning exercise, and the bowler's squat. Generally, muscle activation levels were quite modest even though the tasks were quite strenuous in many cases. Even though similar joint moments were required in different exercises, the pattern of activity between muscles was different. Abdominal bracing increased spine stiffness at the expense of more spine load. Thus, muscle activity seems to be constrained in "functional" exercises. There are several possible reasons for this. Single muscles cannot be activated to 100% of the maximum voluntary contraction in functional exercises because this would upset the balance of moments about the 3 orthopedic axes of the spine, or it would upset the balance of stiffening muscles around the spine required to ensure stability of the spinal column. The one exception was the floor walkout, which resulted in full activation of the rectus abdominis; however, this was a sagittal plane task without the joint moment constraints of multiplanar exercise. Therefore, maximal muscle activity is observed during single-plane tasks, but muscle activation levels were constrained during functional tasks. Thus, strength training muscles may not help in "functional multiplanar" tasks. These data can be used to assist decisions regarding the selection of exercises, specifically choices regarding the starting challenge

  9. Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer’s disease models

    Directory of Open Access Journals (Sweden)

    Bernardi A

    2012-09-01

    Full Text Available Andressa Bernardi,1,* Rudimar L Frozza,2,* André Meneghetti,2 Juliana B Hoppe,2 Ana Maria O Battastini,2 Adriana R Pohlmann,1,3 Sílvia S Guterres,3 Christianne G Salbego21Programa de Pós-Graduação em Ciências Farmacêuticas, 2Instituto de Ciências Básicas da Saúde, 3Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil*These authors contributed equally to this workAbstract: Neuroinflammation, characterized by the accumulation of activated microglia and reactive astrocytes, is believed to modulate the development and/or progression of Alzheimer’s disease (AD. Epidemiological studies suggesting that nonsteroidal anti-inflammatory drugs decrease the risk of developing AD have encouraged further studies elucidating the role of inflammation in AD. Nanoparticles have become an important focus of neurotherapeutic research because they are an especially effective form of drug delivery. Here, we investigate the potential protective effect of indomethacin-loaded lipid-core nanocapsules (IndOH-LNCs against cell damage and neuroinflammation induced by amyloid beta (Aβ1-42 in AD models. Our results show that IndOH-LNCs attenuated Aβ-induced cell death and were able to block the neuroinflammation triggered by Aβ1-42 in organotypic hippocampal cultures. Additionally, IndOH-LNC treatment was able to increase interleukin-10 release and decrease glial activation and c-jun N-terminal kinase phosphorylation. As a model of Aβ-induced neurotoxicity in vivo, animals received a single intracerebroventricular injection of Aβ1-42 (1 nmol/site, and 1 day after Aβ1-42 infusion, they were administered either free IndOH or IndOH-LNCs (1 mg/kg, intraperitoneally for 14 days. Only the treatment with IndOH-LNCs significantly attenuated the impairment of this behavior triggered by intracerebroventricular injection of Aβ1-42. Further, treatment with IndOH-LNCs was able to block the decreased synaptophysin levels induced by Aβ1

  10. Manipulation of subwavelength optical fields and resonant field enhancements of a silver-shell nanocylinder pair and chain waveguides with different core-shell patterns

    Energy Technology Data Exchange (ETDEWEB)

    Chau, Yuan-Fong, E-mail: yfc01@cyu.edu.tw; Li, Huang-Yi; Jiang, Zheng-Hong; Chen, Yi-Fan; Lin, Chih-Sheng; Liu, Min-Shun; Wu, Fong-Lin [Ching Yun University, Department of Electronic Engineering, Taiwan (China); Tsai, Din Ping [National Taiwan University, Department of Physics, Taiwan (China)

    2011-09-15

    Near field optical properties and surface plasmon resonances on a pair of silver-shell nanocylinder and nanochain waveguides with different core-shell patterns which interact with incident plane wave along chain axis are numerically investigated by using the finite element method. Simulation results show that the peak wavelengths and resonant field enhancements are highly tunable by using the nanoshell particles instead of solid ones, revealing a critical relationship among the wavelengths and illuminated direction of incident light, interparticle spacing, radii, and medium of dielectric holes and the patterns of chain waveguides. Besides, nanochain waveguides with different patterns of core-shell that are operated on resonant multipolar modes can provide higher propagation intensities and the transmission ability can be increased by decreasing the size of nanocylinders along the chain axis.

  11. Design of an Adaptive Human-Machine System Based on Dynamical Pattern Recognition of Cognitive Task-Load

    Science.gov (United States)

    Zhang, Jianhua; Yin, Zhong; Wang, Rubin

    2017-01-01

    This paper developed a cognitive task-load (CTL) classification algorithm and allocation strategy to sustain the optimal operator CTL levels over time in safety-critical human-machine integrated systems. An adaptive human-machine system is designed based on a non-linear dynamic CTL classifier, which maps a set of electroencephalogram (EEG) and electrocardiogram (ECG) related features to a few CTL classes. The least-squares support vector machine (LSSVM) is used as dynamic pattern classifier. A series of electrophysiological and performance data acquisition experiments were performed on seven volunteer participants under a simulated process control task environment. The participant-specific dynamic LSSVM model is constructed to classify the instantaneous CTL into five classes at each time instant. The initial feature set, comprising 56 EEG and ECG related features, is reduced to a set of 12 salient features (including 11 EEG-related features) by using the locality preserving projection (LPP) technique. An overall correct classification rate of about 80% is achieved for the 5-class CTL classification problem. Then the predicted CTL is used to adaptively allocate the number of process control tasks between operator and computer-based controller. Simulation results showed that the overall performance of the human-machine system can be improved by using the adaptive automation strategy proposed. PMID:28367110

  12. Concurrent assessments of lower limb loading patterns, mechanical muscle strength and functional performance in ACL-patients - A cross-sectional study

    DEFF Research Database (Denmark)

    Holsgaard-Larsen, Anders; Jensen, C; Mortensen, N H M

    2014-01-01

    Full recovery in muscle strength and functional performance may not be achieved after ACL-injury. Aim: The aim of this study is to investigate loading patterns during jumping, muscle function and functional performance in ACL-reconstructed patients and to investigate the origin of between-limb...

  13. Molecular Biogeography of Tribe Thermopsideae (Leguminosae: A Madrean-Tethyan Disjunction Pattern with an African Origin of Core Genistoides

    Directory of Open Access Journals (Sweden)

    Ming-Li Zhang

    2015-01-01

    Full Text Available Thermopsideae has 45 species and exhibits a series of interesting biogeographical distribution patterns, such as Madrean-Tethyan disjunction and East Asia-North America disjunction, with a center of endemism in the Qinghai-Xizang Plateau (QTP and Central Asia. Phylogenetic analysis in this paper employed maximum likelihood using ITS, rps16, psbA-trnH, and trnL-F sequence data; biogeographical approaches included BEAST molecular dating and Bayesian dispersal and vicariance analysis (S-DIVA. The results indicate that the core genistoides most likely originated in Africa during the Eocene to Oligocene, ca. 55-30 Ma, and dispersed eastward to Central Asia at ca. 33.47 Ma. The origin of Thermopsideae is inferred as Central Asian and dated to ca. 28.81 Ma. Ammopiptanthus is revealed to be a relic. Birth of the ancestor of Thermopsideae coincided with shrinkage of the Paratethys Sea at ca. 30 Ma in the Oligocene. The Himalayan motion of QTP uplift of ca. 20 Ma most likely drove the diversification between Central Asia and North America. Divergences in East Asia, Central Asia, the Mediterranean, and so forth, within Eurasia, except for Ammopiptanthus, are shown to be dispersals from the QTP. The onset of adaptive radiation at the center of the tribe, with diversification of most species in Thermopsis and Piptanthus at ca. 4-0.85 Ma in Tibet and adjacent regions, seems to have resulted from intense northern QTP uplift during the latter Miocene to Pleistocene.

  14. The antiproliferative effect of indomethacin-loaded lipid-core nanocapsules in glioma cells is mediated by cell cycle regulation, differentiation, and the inhibition of survival pathways

    Directory of Open Access Journals (Sweden)

    Bernardi A

    2013-02-01

    Full Text Available Andressa Bernardi,1,* Rudimar L Frozza,2,* Juliana B Hoppe,2 Christianne Salbego,2 Adriana R Pohlmann,1,3 Ana Maria O Battastini,2 Sílvia S Guterres11Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS, Porto Alegre, RS, Brasil; 2Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, RS, Brasil; 3Departamento de Química Orgânica, Instituto de Química, UFRGS, Porto Alegre, RS, Brasil *Both authors contributed equally to this workAbstract: Despite recent advances in radiotherapy, chemotherapy, and surgical techniques, glioblastoma multiforme (GBM prognosis remains dismal. There is an urgent need for new therapeutic strategies. Nanoparticles of biodegradable polymers for anticancer drug delivery have attracted intense interest in recent years because they can provide sustained, controlled, and targeted delivery. Here, we investigate the mechanisms involved in the antiproliferative effect of indomethacin-loaded lipid-core nanocapsules (IndOH-LNC in glioma cells. IndOH-LNC were able to reduce cell viability by inducing apoptotic cell death in C6 and U138-MG glioma cell lines. Interestingly, IndOH-LNC did not affect the viability of primary astrocytes, suggesting that this formulation selectively targeted transformed cells. Mechanistically, IndOH-LNC induced inhibition of cell growth and cell-cycle arrest to be correlated with the inactivation of AKT and ß-catenin and the activation of GSK-3ß. IndOH-LNC also induced G0/G1 and/or G2/M phase arrest, which was accompanied by a decrease in the levels of cyclin D1, cyclin B1, pRb, and pcdc2 and an increase in the levels of Wee1 CDK inhibitor p21WAF1. Additionally, IndOH-LNC promoted GBM cell differentiation, observed as upregulation of glial fibrillary acidic protein (GFAP protein and downregulation of nestin and CD133. Taken together, the crosstalk among antiproliferative effects

  15. Deformation behavior and load limits of asphaltic concrete under the conditions of cores in embankment dams; Deformationsverhalten und Belastungsgrenzen des Asphaltbetons unter den Bedingungen von Staudammkerndichtungen

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, U.

    1998-12-31

    Based on the analysis of existing dams with asphaltic diaphragm and investigations in the three-phase-system of asphaltic concrete a recipe for the composition of asphaltic cores is recommended. For the construction, rest and operating period of an embankment dam the load and the reaction of the asphaltic concrete cores as well as the appearing stress and deformations are described. Extensive material testings have been performed and at 41 asphaltic concrete specimens triaxial stress controlled pressure and creeping tests have been carried out. The evaluation of the triaxial tests led to proportions of the main stress and deformation limits as criteria of breaking. Under application of the standard equation for nonlinear viscoelastic element-laws a rheonom element formulation was developed from the experiment data and transformed into its differential form. With this approach the stress and deformation behavior of watertight asphaltic diaphragm can be precalculated for a period up to 10 years. The applicability of this approach, which can be also used within FE-calculations as well, is illustrated in four examples. (orig.) [Deutsch] Nach der Analyse bestehender Staudaemme mit Asphaltbetonkerndichtung und Untersuchungen zum Dreiphasensystem Asphaltbeton wird eine Rezepturempfehlung fuer den Asphaltkerndichtungsbau aufgestellt. Fuer die Bau-, Ruhe- und Betriebsphase eines Staudammes werden die Beanspruchungen und Reaktionen der Asphaltbetonkerndichtung sowie die auftretenden Spannungen und Verformungen beschrieben. Nach umfangreichen Materialpruefungen sind an 41 Asphaltbetonpruefkoerpern triaxiale spannungsgesteuerte Druck-Kriechversuche durchgefuehrt worden. Die Auswertung der Triaxialversuche ergab ein Grenzhauptspannungsverhaeltnis und Deformationsgrenzen als Bruchkriterien. Unter Verwendung der Standarformulierung fuer nichtlineare viskoelastische Stoffgesetze wurde aus den Versuchsdaten ein rheonomer Stoffansatz entwickelt und in seine differentielle Form

  16. Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients

    Institute of Scientific and Technical Information of China (English)

    Andi Utama; Benyamin Lukito; Tantoro Harmono; Nasrul Zubir; Julius; Soewignjo Soemohardjo; Laurentius Adrianus Lesmana; Ali Sulaiman; Susan Tai; Marlinang Diarta Siburian; Sigit Purwantomo; Mariana Destila Bayu Intan; Tri Shinta Kurniasih; Rino Alvani Gani; Wenny Astuti Achwan; Arnelis; Syafruddin AR Lelosutan

    2011-01-01

    AIM: To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.METHODS: Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study. HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing. Viral load was measured by real-time polymerase chain reaction.RESULTS: Of 179 patients, 108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted. The A1896 mutation was not found in HBeAg(+) patients, however, this mutation was detected in 70.7% of HBeAg(-) patients. This mutation was frequently found when HBeAg was not expressed (87.7%), compared to that found in HBeAg seroconverted patients (65.1%). The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P = 0.004). The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients, however,the prevalence of this mutation did not significantly differ among the two groups (P = 0.054). In HBeAg(+)patients, the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001). The A1899 mutation did not correlate with HBV DNA (P = 0.609). In HBeAg(-)patients, the T1762/A1764 mutation alone was not correlated with HBV DNA (P = 0.095), however, the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION: The percentage of HBeAg(-) patients is high in Indonesia, and most of the HBeAg(-) patients had been seroconverted. The A1896 mutation was most likely the major cause of HBeAg loss. The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients, but not in HBeAg(-) patients.

  17. Effects of Surface Inclination on the Vertical Loading Rates and Landing Pattern during the First Attempt of Barefoot Running in Habitual Shod Runners.

    Science.gov (United States)

    An, W; Rainbow, M J; Cheung, R T H

    2015-01-01

    Barefoot running has been proposed to reduce vertical loading rates, which is a risk factor of running injuries. Most of the previous studies evaluated runners on level surfaces. This study examined the effect of surface inclination on vertical loading rates and landing pattern during the first attempt of barefoot running among habitual shod runners. Twenty habitual shod runners were asked to run on treadmill at 8.0 km/h at three inclination angles (0°; +10°; -10°) with and without their usual running shoes. Vertical average rate (VALR) and instantaneous loading rate (VILR) were obtained by established methods. Landing pattern was decided using high-speed camera. VALR and VILR in shod condition were significantly higher (p barefoot condition (p > 0.382). There was no difference (p > 0.413) in the landing pattern among all surface inclinations. Only one runner demonstrated complete transition to non-heel strike landing in all slope conditions. Reducing heel strike ratio in barefoot running did not ensure a decrease in loading rates (p > 0.15). Conversely, non-heel strike landing, regardless of footwear condition, would result in a softer landing (p < 0.011).

  18. Effects of Surface Inclination on the Vertical Loading Rates and Landing Pattern during the First Attempt of Barefoot Running in Habitual Shod Runners

    Directory of Open Access Journals (Sweden)

    W. An

    2015-01-01

    Full Text Available Barefoot running has been proposed to reduce vertical loading rates, which is a risk factor of running injuries. Most of the previous studies evaluated runners on level surfaces. This study examined the effect of surface inclination on vertical loading rates and landing pattern during the first attempt of barefoot running among habitual shod runners. Twenty habitual shod runners were asked to run on treadmill at 8.0 km/h at three inclination angles (0°; +10°; −10° with and without their usual running shoes. Vertical average rate (VALR and instantaneous loading rate (VILR were obtained by established methods. Landing pattern was decided using high-speed camera. VALR and VILR in shod condition were significantly higher (p0.382. There was no difference (p>0.413 in the landing pattern among all surface inclinations. Only one runner demonstrated complete transition to non-heel strike landing in all slope conditions. Reducing heel strike ratio in barefoot running did not ensure a decrease in loading rates (p>0.15. Conversely, non-heel strike landing, regardless of footwear condition, would result in a softer landing (p<0.011.

  19. Synthesis and drug-loading properties of folic acid-modified superparamagnetic Fe3O4 hollow microsphere core/mesoporous SiO2 shell composite particles

    Science.gov (United States)

    Yang, Yong; Guo, Xue; Wei, Kaiwei; Wang, Lijuan; Yang, Dandan; Lai, Lifang; Cheng, Meiling; Liu, Qi

    2014-01-01

    A drug delivery system, which not only has superparamagnetic property, higher surface area but also has targeting function, has been developed. The core/shell structural magnetic magnetite mesoporous silica microspheres with amine groups (Fe3O4-SiO2-NH2) were first fabricated by a one-pot direct co-condensation method, then folic acid-modified magnetic mesoporous silica composite microspheres (Fe3O4-SiO2-NHFA) were obtained by the bonding of the Fe3O4-SiO2-NH2 with folic acid as targeted molecule. The resultant composite microspheres were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, scanning electron microscopy, low temperature nitrogen adsorption-desorption, and vibrating sample magnetometer. A well-known inflammational drug ibuprofen was used as a model drug to assess the loading and releasing behavior of the composite microspheres. Fe3O4-SiO2-NHFA system exhibits magnetic properties typical for superparamagnetic material with a higher saturation magnetization value of about 41.2 emu/g and has better capacity of drug storage (32.0 %) and sustained drug-release property. So this system has potential applications in biomedical field.

  20. Liquid-core alginate hydrogel beads loaded with functional compounds of radish by-products by reverse spherification: Optimization by response surface methodology.

    Science.gov (United States)

    Tsai, Fu-Hsuan; Kitamura, Yutaka; Kokawa, Mito

    2017-03-01

    Liquid-core hydrogel beads (LHB) were formulated through reverse spherification, by sodium alginate and using calcium lactate (CL) to replace the common calcium source, calcium chloride. The effect of four independent variables: first gelation time (X1), CL concentration in first gelation (X2), secondary gelation time (X3), and CL concentration in secondary gelation (X4), on seven physical properties of LHB: diameter, hardness (Y1), loading efficiency (LE, Y2), release amount of total phenolic compounds (TP) in simulated gastric (Y3) and small intestinal (Y4) fluid, swelling capacity (Y5), and sphericity (Y6), were evaluated. Furthermore, a central composite design with response surface methodology was used for the optimization of LHB properties Y1-Y6, and the importance of the four independent variables to physical properties was analyzed. The diameter of LHB was in the range of 4.17-5.84mm. The optimal conditions of LHB formulation were first gelation time of 23.99min, 0.13M CL in the first gelation, secondary gelation time of 6.04min, and 0.058M CL in secondary gelation. The optimized formulation of LHB demonstrated 25.5N of hardness, 85.67% of LE and 27.38% of TP release in simulated gastric fluid with the small error-values (-2.47 to 2.21%).

  1. Self-catalyzed ternary core-shell GaAsP nanowire arrays grown on patterned Si substrates by molecular beam epitaxy.

    Science.gov (United States)

    Zhang, Yunyan; Wu, Jiang; Aagesen, Martin; Holm, Jeppe; Hatch, Sabina; Tang, Mingchu; Huo, Suguo; Liu, Huiyun

    2014-08-13

    The growth of self-catalyzed ternary core-shell GaAsP nanowire (NW) arrays on SiO2 patterned Si(111) substrates has been demonstrated by using solid-source molecular beam epitaxy. A high-temperature deoxidization step up to ∼ 900 °C prior to NW growth was used to remove the native oxide and/or SiO2 residue from the patterned holes. To initiate the growth of GaAsP NW arrays, the Ga predeposition used for assisting the formation of Ga droplets in the patterned holes, was shown to be another essential step. The effects of the patterned-hole size on the NW morphology were also studied and explained using a simple growth model. A lattice-matched radial GaAsP core-shell NW structure has subsequently been developed with room-temperature photoluminescence emission around 740 nm. These results open up new perspectives for integrating position-controlled III-V NW photonic and electronic structures on a Si platform.

  2. Core disgust and moral disgust are related to distinct spatiotemporal patterns of neural processing: an event-related potential study.

    Science.gov (United States)

    Luo, Yu; Shen, Weilin; Zhang, Yu; Feng, Ting-yong; Huang, Hao; Li, Hong

    2013-10-01

    Core disgust is thought to rely more on sensory and perceptual processes, whereas moral disgust is thought to rely more on social evaluation processes. However, little is known about the neurocognitive mechanisms underlying these two types of disgust. We recorded event-related potentials (ERPs) from participants while they performed a lexical decision task in which core- and moral-disgust words were intermixed with neutral words and pseudowords. Lexical judgment was faster for coredisgust words and slower for moral-disgust words, relative to the neutral words. Core-disgust words, relative to neutral words, elicited a larger early posterior negative (EPN), a larger N320, a smaller N400, and a larger late positive component (LPC), whereas moral disgust words elicited a smaller N320 and a larger N400 than neutral words. These results suggest that the N320 and N400 components are particularly sensitive to the neurocognitive processes that overlap in processing both core and moral disgust, whereas the EPN and LPC may reflect process that are particularly sensitive to core disgust.

  3. Numerical analysis of the damage on Ⅰ-core sandwich panels subjected to combined blast and fragment loading%冲击波和破片联合作用下Ⅰ型夹层板毁伤仿真

    Institute of Scientific and Technical Information of China (English)

    段新峰; 程远胜; 张攀; 刘均; 李勇

    2015-01-01

    基于非线性有限元软件LS-DYNA,通过在TNT炸药底部布置预制破片模拟战斗部爆炸产生的冲击波与破片联合作用载荷,计算3种TNT炸药当量下Ⅰ型夹层板的毁伤响应,分析冲击波单独作用及冲击波与破片联合作用下Ⅰ型夹层板失效模式的差异,研究夹层板芯层配置以及上、下面板厚度配置对其失效模式的影响,并与等效实体板的抗毁伤性能进行对比.同时,从吸能的角度分析不同载荷工况下Ⅰ型夹层板的吸能特性.数值仿真结果表明:在冲击波与破片联合作用下,结构的毁伤程度远大于冲击波单独作用时;当载荷强度较小时,I型夹层板的抗毁伤性能优于等效实体板;载荷强度、载荷类型(冲击波单独作用或冲击波与破片联合作用)及上、下面板厚度配置对Ⅰ型夹层板的失效模式有较大影响;从吸能特性来看,在冲击波单独作用下,上面板和芯层是主要的吸能构件,而在冲击波与破片联合作用下,上面板和下面板是主要的吸能构件.%In this paper, the combined blast and fragment loads due to close-in warhead explosion is simu-lated by placing prefabricated fragments at the bottom of bare TNT explosive, and the corresponding dam-age on Ⅰ-core sandwich panels are evaluated using the software LS-DYNA. The differences of failure modes of sandwich panels subjected to only blast and combined blast and fragment loads are analyzed, and the effects of core configuration and thickness configuration between the front and back plates on the fail-ure modes are studied. The anti-damage performance of sandwich panels is then compared with that of the equivalent solid plate. In addition, the energy absorption characteristics of Ⅰ-core sandwich panels under different loads are also analyzed. Numerical results show that the overall damage of both the sandwich pan-els and solid plates subjected to combined blast and fragment loads is more severe than that caused

  4. Haloperidol-loaded lipid-core polymeric nanocapsules reduce DNA damage in blood and oxidative stress in liver and kidneys of rats

    Science.gov (United States)

    Roversi, Katiane; Benvegnú, Dalila M.; Roversi, Karine; Trevizol, Fabíola; Vey, Luciana T.; Elias, Fabiana; Fracasso, Rafael; Motta, Mariana H.; Ribeiro, Roseane F.; dos S. Hausen, Bruna; Moresco, Rafael N.; Garcia, Solange C.; da Silva, Cristiane B.; Burger, Marilise E.

    2015-04-01

    Haloperidol (HP) nanoencapsulation improves therapeutic efficacy, prolongs the drug action time, and reduces its motor side effects. However, in a view of HP toxicity in organs like liver and kidneys in addition to the lack of knowledge regarding the toxicity of polymeric nanocapsules, our aim was to verify the influence of HP-nanoformulation on toxicity and oxidative stress markers in the liver and kidneys of rats, also observing the damage caused in the blood. For such, 28 adult male Wistar rats were designated in four experimental groups ( n = 7) and treated with vehicle (C group), free haloperidol suspension (FH group), blank nanocapsules suspension (B-Nc group), and haloperidol-loaded lipid-core nanocapsules suspension (H-Nc group). The nanocapsules formulation presented the size of approximately 250 nm. All suspensions were administered to the animals (0.5 mg/kg/day-i.p.) for a period of 28 days. Our results showed that FH caused damage in the liver, evidenced by increased lipid peroxidation, plasma levels of aspartate aminotransferase, and alanine aminotransferase, as well as decreased cellular integrity and vitamin C levels. In kidneys, FH treatment caused damage to a lesser extent, observed by decreased activity of δ-aminolevulinate dehydratase (ALA-D) and levels of VIT C. In addition, FH treatment was also related to a higher DNA damage index in blood. On the other hand, animals treated with H-Nc and B-Nc did not show damage in liver, kidneys, and DNA. Our study indicates that the nanoencapsulation of haloperidol was able to prevent the sub-chronic toxicity commonly observed in liver, kidneys, and DNA, thus reflecting a pharmacological superiority in relation to free drug.

  5. Haloperidol-loaded lipid-core polymeric nanocapsules reduce DNA damage in blood and oxidative stress in liver and kidneys of rats

    Energy Technology Data Exchange (ETDEWEB)

    Roversi, Katiane, E-mail: katianeroversi@gmail.com [Universidade Federal de Santa Maria, Programa de Pós-Graduação em Farmacologia (Brazil); Benvegnú, Dalila M., E-mail: dalilabenvegnu@yahoo.com.br [Universidade Federal da Fronteira Sul (UFFS), Bioquímica e Farmacologia (Brazil); Roversi, Karine, E-mail: karineroversi-@hotmail.com [Universidade Federal de Santa Maria (UFSM), Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde (Brazil); Trevizol, Fabíola, E-mail: fatrevizol@yahoo.com.br [Universidade Federal de Santa Maria, Programa de Pós-Graduação em Farmacologia (Brazil); Vey, Luciana T., E-mail: luciana.taschetto@hotmail.com [Universidade Federal de Santa Maria (UFSM), Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde (Brazil); Elias, Fabiana, E-mail: fabiana.elias@uffs.edu.br [Universidade Federal da Fronteira Sul (UFFS), Bioquímica e Farmacologia (Brazil); Fracasso, Rafael, E-mail: rafael.fra@hotmail.com [Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências Farmacêuticas (Brazil); and others

    2015-04-15

    Haloperidol (HP) nanoencapsulation improves therapeutic efficacy, prolongs the drug action time, and reduces its motor side effects. However, in a view of HP toxicity in organs like liver and kidneys in addition to the lack of knowledge regarding the toxicity of polymeric nanocapsules, our aim was to verify the influence of HP-nanoformulation on toxicity and oxidative stress markers in the liver and kidneys of rats, also observing the damage caused in the blood. For such, 28 adult male Wistar rats were designated in four experimental groups (n = 7) and treated with vehicle (C group), free haloperidol suspension (FH group), blank nanocapsules suspension (B-Nc group), and haloperidol-loaded lipid-core nanocapsules suspension (H-Nc group). The nanocapsules formulation presented the size of approximately 250 nm. All suspensions were administered to the animals (0.5 mg/kg/day-i.p.) for a period of 28 days. Our results showed that FH caused damage in the liver, evidenced by increased lipid peroxidation, plasma levels of aspartate aminotransferase, and alanine aminotransferase, as well as decreased cellular integrity and vitamin C levels. In kidneys, FH treatment caused damage to a lesser extent, observed by decreased activity of δ-aminolevulinate dehydratase (ALA-D) and levels of VIT C. In addition, FH treatment was also related to a higher DNA damage index in blood. On the other hand, animals treated with H-Nc and B-Nc did not show damage in liver, kidneys, and DNA. Our study indicates that the nanoencapsulation of haloperidol was able to prevent the sub-chronic toxicity commonly observed in liver, kidneys, and DNA, thus reflecting a pharmacological superiority in relation to free drug.

  6. Plasmonic spectrum on 1D and 2D periodic arrays of rod-shape metal nanoparticle pairs with different core patterns for biosensor and solar cell applications

    Science.gov (United States)

    Kumara, N. T. R. N.; Chou Chau, Yuan-Fong; Huang, Jin-Wei; Huang, Hung Ji; Lin, Chun-Ting; Chiang, Hai-Pang

    2016-11-01

    Simulations of surface plasmon resonance (SPR) on the near field intensity and absorption spectra of one-dimensional (1D) and two-dimensional (2D) periodic arrays of rod-shape metal nanoparticle (MNP) pairs using the finite element method (FEM) and taking into account the different core patterns for biosensor and solar cell applications are investigated. A tunable optical spectrum corresponding to the transverse SPR modes is observed. The peak resonance wavelength (λ res) can be shifted to red as the core patterns in rod-shape MNPs have been changed. We find that the 2D periodic array of core-shell MNP pairs (case 2) exhibit a red shifted SPR that can be tuned the gap enhancement and absorption efficiency simultaneously over an extended wavelength range. The tunable optical performances give us a qualitative idea of the geometrical properties of the periodic array of rod-shape MNP pairs on SPRs that can be as a promising candidate for plasmonic biosensor and solar cell applications.

  7. Comparison of Anchorage Pattern under Two Types of Orthodontic Mini- Implant Loading During Retraction in Type A Anchorage Cases

    Science.gov (United States)

    Khan, B. Imran; Mandava, Prasad; Reddy, G. Vivek; Nettam, Venkatesh; Bhavikati, Venkat Naidu

    2016-01-01

    Introduction The orthodontic mini-screws are the mainstay of direct skeletal anchorage which requires minimal compliance and provides maximal anchorage control. However, the timing of initiation of orthodontic loading of these mini-screws is not clearly established in the available studies. Aim The purpose of this study was to determine the reciprocal effects on mini-screw implant with immediate loading in comparison to that of delayed loading during retraction. Materials and Methods The prospective clinical study included a sample of 25 orthodontic patients in the age range of 18-25 years. All the cases were of bi-maxillary proclination with Type-A anchorage demands. All the first premolars were indicated for extraction. A split mouth technique for each patient was utilized by loading mini-implant immediately after its placement on one side and the opposite side implant was loaded after a time lag of two weeks post-insertion. Retraction force of 150g was applied for three months on each side. The displacement of the head and tail of the implant, molar anterior tooth retraction was measured on Orthopantomograph (OPG) taken at T1 (initial) and T2 (after three months). A grid method with each 1mm magnified to 500 pixels was superimposed on OPG and the relative displacements were evaluated. Student’s unpaired ‘t’ test was used for comparison between left and right side and paired ‘t’ test for the parameters on the same side. The p-value equal to or less than 0.05 was taken as statistically significant. Results The mean displacement of head of the implant on the immediate loading is 0.57mm where as the tail exhibited 0.75 mm. The head and tail of the implant on the delayed loading displaced by 0.35mm and 0.38mm respectively, on an average when data was analysed. Significant difference between the two types of loading was noted. Conclusion Delayed loading is beneficial as compared to immediate loading during extraction space closure. PMID:27891469

  8. Core disgust and moral disgust are related to distinct spatiotemporal patterns of neural processing: an event-related potential study

    NARCIS (Netherlands)

    Luo, Y.; Shen, W.; Zhang, Y.; Feng, T.Y.; Huang, H.; Li, H.

    2013-01-01

    Core disgust is thought to rely more on sensory and perceptual processes, whereas moral disgust is thought to rely more on social evaluation processes. However, little is known about the neurocognitive mechanisms underlying these two types of disgust. We recorded event-related potentials (ERPs) from

  9. Acetylation and methylation patterns of core histones are modified after heat or arsenite treatment of Drosophila tissue culture cells

    OpenAIRE

    Arrigo, André-Patrick

    1983-01-01

    Exposure of Drosophilamelanogaster tissue culture cells to 37°C (heat shock) or to arsenite induces a severe deacetylation of core histones and blocks the methylation of histone H3 and H4. Heat shock induces the methylation of histone H2b. These results are discussed in view of chromatin structure and function.

  10. Can We Tell the Inner Core Size and the Heat Flow Pattern inside a Planet from the Observed Magnetic Field?

    Science.gov (United States)

    Cao, H.; Russell, C. T.; Wicht, J.; Christensen, U. R.

    2012-09-01

    Several distinct features of Saturn's magnetic field have been revealed in a recent study based on in-situ magnetic field measurements made by the Cassini spacecraft [1]. The field at the dynamo surface is found to be strongly concentrated near the spin-poles with little hemispherical asymmetry. This field geometry corresponds to a zig-zag shape magnetic spectrum with pronounced odd degree terms and all odd degree magnetic moments possess the same sign ( , and all be positive in this case). This is in contrast to the field properties at the outer core surface of the Earth, where the field near the spinpoles is at a relative minimum compared to field at mid-latitude (see Fig. 1). An anticyclonic polar vortex with upwelling flow inside the tangent cylinder (the tangent cylinder is an imaginary cylinder parallel to the spin axis and tangent to the inner core surface at the equator) has been inferred at the Earth's core surface from geomagnetic secular variation analyses [2]. The associated advective transport of magnetic field is like responsible for the typical minimum or inverse geomagnetic field at high latitudes and the pronounced flux patches at midlatitudes. This feature is also frequently found in convectively driven geodynamo models [3].

  11. Methotrexate-loaded lipid-core nanocapsules are highly effective in the control of inflammation in synovial cells and a chronic arthritis model

    Directory of Open Access Journals (Sweden)

    Boechat AL

    2015-10-01

    Full Text Available Antônio Luiz Boechat,1,2,* Catiúscia Padilha de Oliveira,3,* Andrea Monteiro Tarragô,2 Allyson Guimarães da Costa,2 Adriana Malheiro,1,2 Silvia Stanisçuaski Guterres,3 Adriana Raffin Pohlmann3,41Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, 2Programa de Pós-Graduação e Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Manaus, 3Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, 4Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil*These authors contributed equally to this workBackground: Rheumatoid arthritis (RA is the most common autoimmune disease in the word, affecting 1% of the population. Long-term prognosis in RA was greatly improved following the introduction of highly effective medications such as methotrexate (MTX. Despite the importance of this drug in RA, 8%–16% of patients must discontinue the treatment because of adverse effects. Last decade, we developed a promising new nanocarrier as a drug-delivery system, lipid-core nanocapsules.Objective: The aim of the investigation reported here was to evaluate if methotrexate-loaded lipid-core nanocapsules (MTX-LNC reduce proinflammatory and T-cell-derived cytokines in activated mononuclear cells derived from RA patients and even in functional MTX-resistant conditions. We also aimed to find out if MTX-LNC would reduce inflammation in experimentally inflammatory arthritis at lower doses than MTX solution.Methods: Formulations were prepared by self-assembling methodology. The adjuvant arthritis was induced in Lewis rats (AIA and the effect on edema formation, TNF-a levels, and interleukin-1 beta levels after treatment was evaluated. Mononuclear cells obtained from the synovial fluid of RA patients during articular infiltration procedures were treated with MTX solution and MTX-LNC. For in vitro experiments

  12. Evaluation of stress pattern generated through various thread designs of dental implants loaded in a condition of immediately after placement and on osseointegration--an FEA study.

    Science.gov (United States)

    Chowdhary, Ramesh; Halldin, Anders; Jimbo, Ryo; Wennerberg, Ann

    2013-02-01

    To determine the stress pattern generated through various thread design in experimental simulation models, when loaded immediately after placement and after osseointegration. Three-dimensional (3D) models were designed using CATIA, computer-aided design modeling software. The study was planned in 2 stages. Eight 2D models were constructed of different thread forms, one set with frictionless and other with bonded for bone to implant interface and loaded vertically with 100 N. In Stage II, 6 3D models of the different threads embedded in the cortical bone were constructed and loaded vertically and obliquely. In 2D models, the von Mises stress concentrated at the crest in the bonded connection thread designs. The stress levels were in the range of 7 to 13 MPa. In the frictional implant bone interface, the thread designs had a clear effect on the stress levels in the bone. In the 3D analysis, the complete implant design affected the stress levels. The thread design affects the magnitude of the stress peak in the bone more effectively in immediately loaded (frictionless) implants than the osseointegrated (bonded) implants. Maximum stress was observed at the first thread in most of the osseointegrated implants.

  13. Quantify work load and muscle functional activation patterns in neck-shoulder muscles of female sewing machine operators using surface electromyogram.

    Science.gov (United States)

    Zhang, Fei-Ruo; He, Li-Hua; Wu, Shan-Shan; Li, Jing-Yun; Ye, Kang-Pin; Wang, Sheng

    2011-11-01

    Work-related musculoskeletal disorders (WMSDs) have high prevalence in sewing machine operators employed in the garment industry. Long work duration, sustained low level work and precise hand work are the main risk factors of neck-shoulder disorders for sewing machine operators. Surface electromyogram (sEMG) offers a valuable tool to determine muscle activity (internal exposure) and quantify muscular load (external exposure). During sustained and/or repetitive muscle contractions, typical changes of muscle fatigue in sEMG, as an increase in amplitude or a decrease as a shift in spectrum towards lower frequencies, can be observed. In this paper, we measured and quantified the muscle load and muscular activity patterns of neck-shoulder muscles in female sewing machine operators during sustained sewing machine operating tasks using sEMG. A total of 18 healthy women sewing machine operators volunteered to participate in this study. Before their daily sewing machine operating task, we measured the maximal voluntary contractions (MVC) and 20%MVC of bilateral cervical erector spinae (CES) and upper trapezius (UT) respectively, then the sEMG signals of bilateral UT and CES were monitored and recorded continuously during 200 minutes of sustained sewing machine operating simultaneously which equals to 20 time windows with 10 minutes as one time window. After 200 minutes' work, we retest 20%MVC of four neck-shoulder muscles and recorded the sEMG signals. Linear analysis, including amplitude probability distribution frequency (APDF), amplitude analysis parameters such as roof mean square (RMS) and spectrum analysis parameter as median frequency (MF), were used to calculate and indicate muscle load and muscular activity of bilateral CES and UT. During 200 minutes of sewing machine operating, the median load for the left cervical erector spinae (LCES), right cervical erector spinae (RCES), left upper trapezius (LUT) and right upper trapezius (RUT) were 6.78%MVE, 6.94%MVE, 6

  14. Modeling of plug-in electric vehicle travel patterns and charging load based on trip chain generation

    Science.gov (United States)

    Wang, Dai; Gao, Junyu; Li, Pan; Wang, Bin; Zhang, Cong; Saxena, Samveg

    2017-08-01

    Modeling PEV travel and charging behavior is the key to estimate the charging demand and further explore the potential of providing grid services. This paper presents a stochastic simulation methodology to generate itineraries and charging load profiles for a population of PEVs based on real-world vehicle driving data. In order to describe the sequence of daily travel activities, we use the trip chain model which contains the detailed information of each trip, namely start time, end time, trip distance, start location and end location. A trip chain generation method is developed based on the Naive Bayes model to generate a large number of trips which are temporally and spatially coupled. We apply the proposed methodology to investigate the multi-location charging loads in three different scenarios. Simulation results show that home charging can meet the energy demand of the majority of PEVs in an average condition. In addition, we calculate the lower bound of charging load peak on the premise of lowest charging cost. The results are instructive for the design and construction of charging facilities to avoid excessive infrastructure.

  15. 454 Pyrosequencing Analysis of Fungal Assemblages from Geographically Distant, Disparate Soils Reveals Spatial Patterning and a Core Mycobiome

    Directory of Open Access Journals (Sweden)

    Mariangela Girlanda

    2013-02-01

    Full Text Available Identifying a soil core microbiome is crucial to appreciate the established microbial consortium, which is not usually subjected to change and, hence, possibly resistant/resilient to disturbances and a varying soil context. Fungi are a major part of soil biodiversity, yet the mechanisms driving their large-scale ecological ranges and distribution are poorly understood. The degree of fungal community overlap among 16 soil samples from distinct ecosystems and distant geographic localities (truffle grounds, a Mediterranean agro-silvo-pastoral system, serpentine substrates and a contaminated industrial area was assessed by examining the distribution of fungal ITS1 and ITS2 sequences in a dataset of 454 libraries. ITS1 and ITS2 sequences were assigned to 1,660 and 1,393 Operational Taxonomic Units (OTUs; as defined by 97% sequence similarity, respectively. Fungal beta-diversity was found to be spatially autocorrelated. At the level of individual OTUs, eight ITS1 and seven ITS2 OTUs were found in all soil sample groups. These ubiquitous taxa comprised generalist fungi with oligotrophic and chitinolytic abilities, suggesting that a stable core of fungi across the complex soil fungal assemblages is either endowed with the capacity of sustained development in the nutrient-poor soil conditions or with the ability to exploit organic resources (such as chitin universally distributed in soils.

  16. Sea-salt aerosol transport patterns over the Northern Hemisphere inferred from two subarctic ice core records

    Institute of Scientific and Technical Information of China (English)

    YAN Yuping; KANG Shichang; SUN Junying; Paul A. Mayewski; QIN Dahe

    2005-01-01

    Atmospheric circulation reconstruction based on glaciochemical records requires knowledge of chemical concentration controls, such as source, transport pathway and strength. To gain insight into these processes, the relationships between glaciochemical records from two Northern Hemisphere sites (Mt. Logan in Yukon Territory and 20D in southern Greenland) and instrumental sea level pressure (SLP) series are investigated. Calibrations between Mt. Logan sea-salt sodium (ssNa+) concentration and SLP series show that ssNa+ concentrations are closely correlated with the autumntime (SON) Aleutian Low and the summertime (JJA) North Pacific Subtropical High. Both the deepened Aleutian Low and enhanced North Pacific Subtropical High strengthen the transport of sea-salt aerosols from the North Pacific to the Mt. Logan region. Calibrations between 20D ssNa+ concentrations and SLP series indicate that ssNa+ concentrations are closely related to the wintertime (Jan.) Icelandic Low. A deepening of the Icelandic Low strengthens winter storms and frequent cyclogenesis over the North Atlantic and pushes more sea-salt laden air masses to the Greenland ice sheet. Therefore, ice core ssNa+ records from the Mt. Logan region can be considered as a proxy for reconstructing the autumntime Aleutian Low and summertime North Pacific Subtropical High, and the ssNa+ records from Greenland ice core (20D) may provide a proxy for reconstructing the wintertime Icelandic Low.

  17. Molecular biogeography of tribe Thermopsideae (Leguminosae): A Madrean-Tethyan disjunction pattern with an African origin of core genistoides

    Science.gov (United States)

    Ming-Li Zhang; Jian-Feng Huang; Stewart C. Sanderson; Ping Yan; Yu-H Wu; Bo-Rong Pan

    2015-01-01

    Thermopsideae has 45 species and exhibits a series of interesting biogeographical distribution patterns, such as Madrean-Tethyan disjunction and EastAsia-North America disjunction,with a center of endemism in the Qinghai-Xizang Plateau (QTP) and Central Asia. Phylogenetic analysis in this paper employed maximum likelihood using ITS, rps16, psbA-trnH, and trnL-F...

  18. Dietary patterns in the population living in the Sami core areas of Norway--the SAMINOR study

    OpenAIRE

    Brustad, Magritt; Parr, Christine L; Melhus, Marita; Lund, Eiliv

    2008-01-01

    OBJECTIVES: To identify dietary patterns and to investigate their association with selected life-style and demographic factors, ethnicity and self-perceived health. Study design. Population-based cross-sectional design, using food frequency questionnaires. METHODS: A total of 12,811 subjects aged 36-79 years participated from the municipalities in Norway where more than 5-10% of the population reported to be Simi in the 1970 Census, in addition to some selected districts. The data were colle...

  19. ASBLT: a system of DATATRAN MODULES which process core fuel loading for use in as-built calculations (LWBR Development Program)

    Energy Technology Data Exchange (ETDEWEB)

    Beaudoin, B.R.; Beggs, W.J.; Case, C.R.; Wilczynski, R.

    1979-02-01

    ASBLT is a computer program consisting of DATATRAN MODULES which was used during the manufacturing phase of LWBR to collect and evaluate as-built data. The program was part of the LWBR fuel rod inspection process and produced sections of module assembly certification reports. ASBLT used fuel pellet, fuel rod and module assembly data to compute core inventories and to supply input to nuclear design programs for as-built core calculations.

  20. Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage

    Directory of Open Access Journals (Sweden)

    Charão MF

    2015-08-01

    Full Text Available Mariele Feiffer Charão,1,2 Caroline Souto,2 Natália Brucker,1,2 Anelise Barth,1,2 Denise S Jornada,1,3 Daiandra Fagundez,4 Daiana Silva Ávila,4 Vera L Eifler-Lima,1,5 Silvia S Guterres,1,3 Adriana R Pohlmann,1,6 Solange Cristina Garcia1,21Post-Graduate Programme in Pharmaceutical Sciences, 2Laboratory of Toxicology (LATOX, Department of Analysis, Pharmacy Faculty, 3Department of Production and Control of Drugs, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, 4Research Group in Biochemistry and Toxicology in Caenorhabditis elegans (GBToxCE, Federal University of Pampa – UNIPAMPA, Uruguaiana, 5Laboratory of Medical Synthesis Organic (LaSOM, Pharmacy Faculty, 6Department of Organic Chemistry, Chemistry Institute, Federal University of Rio Grande do Sul, Porto Alegre, RS, BrazilAbstract: Caenorhabditis elegans is an alternative in vivo model that is being successfully used to assess the pharmacological and toxic effects of drugs. The exponential growth of nanotechnology requires the use of alternative in vivo models to assess the toxic effects of theses nanomaterials. The use of polymeric nanocapsules has shown promising results for drug delivery. Moreover, these formulations have not been used in cases of intoxication, such as in treatment of paraquat (PQ poisoning. Thus, the use of drugs with properties improved by nanotechnology is a promising approach to overcome the toxic effects of PQ. This research aimed to evaluate the absorption of rhodamine B-labeled melatonin (Mel-loaded lipid-core nanocapsules (LNC by C. elegans, the application of this model in nanotoxicology, and the protection of Mel-LNC against PQ damage. The formulations were prepared by self-assembly and characterized by particle sizing, zeta potential, drug content, and encapsulation efficiency. The results demonstrated that the formulations had narrow size distributions. Rhodamine B-labeled Mel-LNC were orally absorbed and distributed in the worms

  1. Implications of MODIS impression of aerosol loading over urban and rural settlements in Nigeria: Possible links to energy consumption patterns in the country

    Science.gov (United States)

    Dom Onyeuwaoma, Nnaemeka

    2016-07-01

    A study of aerosol loading patterns in some selected cities in Nigeria was carried out using MODIS, TOMS/OMI AND AIRS satellite imageries for a period of 10 years. The results showed that an aerosol optical depth (AOD) loading obtained ranged from 0.02-0.9, UV aerosol index (AI) and carbon monoxide (CO) results ranged from 1.32- 2.43 and 2.22-2.6 molecule/cm2, respectively. The CO data was used to infer the presence of carbonecous aerosols from biomass, fossil combustion and industrial activities. This result indicates that areas with higher AOD and AI do not correspond in high CO loading. From the HYSPLIT and HAT analysis conducted it showed that advection plays important role in the dispersion of aerosols. This implies that aerosols can reside in a place remote from where they are generated. Also, the high concentration of CO aerosol in the southern cities suggests a high rate of industrial pollution as a result of fossil fuel burning, vehicular emissions, high population density and gas flaring. Therefore, emphasis should be on the need to switch to renewable energy options as an alternative to fossil fuel. Furthermore, plans for mitigations should not be limited to industrialized cities only but extended to other cities which might be bearing the real brunt of industrial emissions as shown in this work.

  2. Seasonal patterns in immune indices reflect microbial loads on birds but not microbes in the wider environment

    NARCIS (Netherlands)

    Horrocks, N.P.C.; Matson, K.D.; Shobrak, M.; Tinbergen, J.M.; Tieleman, B.I.

    2012-01-01

    Documenting patterns in immune function is a first step to understanding immune variation, but to comprehend causes and consequences, antigen and parasite exposure that may drive such variation must be determined. We measured host-independent microbial exposure in five species of larks (Alaudidae) i

  3. Photovoltaic array capacity determined by considering the environmental factors for load patterns; Fuka pattern ni taisuru kankyo inshi wo koryoshita taiyo denchi array yoryo no kettei

    Energy Technology Data Exchange (ETDEWEB)

    Kameyama, N.; Higuchi, T.; Yamagami, Y.; Tani, T. [Science University of Tokyo, Tokyo (Japan). Faculty of Engineering

    1997-01-30

    Effectiveness of the spectral method was confirmed for system interconnection type photovoltaic (PV) power generation systems, and PV array capacity determined in harmony with the power load was investigated. In this study, system interconnection type PV power generation systems with polycrystalline Si and amorphous Si PV cell modules were discussed. The output electric energy evaluated by the spectral method was compared with that evaluated by the conventional method only considering the cell temperature. Obtained results are as follows. For the polycrystalline Si, the differences between solar supply rates in summer evaluated by the both methods and measured value were less than 2%, which resulted in the accurate determination. For the amorphous Si, however, the difference less than 3% was obtained by the spectral method and that less than 11% was obtained by the conventional method. The spectral method provided higher accuracy. When constructing a system with large array capacity, it was found that the optimum design of PV power generation system can be performed using the spectral method with less array capacity than using the conventional method. 4 refs., 9 figs., 4 tabs.

  4. Photovoltaic array capacity determined by considering the environmental factors for load patterns; Fuka pattern ni taisuru kankyo inshi wo koryoshita taiyo denchi array yoryo no kettei

    Energy Technology Data Exchange (ETDEWEB)

    Kameyama, N.; Higuchi, T.; Yamagami, Y.; Tani, T. [Science University of Tokyo, Tokyo (Japan). Faculty of Engineering

    1997-01-30

    Effectiveness of the spectral method was confirmed for system interconnection type photovoltaic (PV) power generation systems, and PV array capacity determined in harmony with the power load was investigated. In this study, system interconnection type PV power generation systems with polycrystalline Si and amorphous Si PV cell modules were discussed. The output electric energy evaluated by the spectral method was compared with that evaluated by the conventional method only considering the cell temperature. Obtained results are as follows. For the polycrystalline Si, the differences between solar supply rates in summer evaluated by the both methods and measured value were less than 2%, which resulted in the accurate determination. For the amorphous Si, however, the difference less than 3% was obtained by the spectral method and that less than 11% was obtained by the conventional method. The spectral method provided higher accuracy. When constructing a system with large array capacity, it was found that the optimum design of PV power generation system can be performed using the spectral method with less array capacity than using the conventional method. 4 refs., 9 figs., 4 tabs.

  5. HYBRID GREY WOLF OPTIMIZATION-PATTERN SEARCH (hGWO-PS OPTIMIZED 2DOF-PID CONTROLLERS FOR LOAD FREQUENCY CONTROL (LFC IN INTERCONNECTED THERMAL POWER PLANTS

    Directory of Open Access Journals (Sweden)

    V Soni

    2016-04-01

    Full Text Available The combination of Grey Wolf Optimization and Pattern Search Technique (hGWO-PS has been introduced to optimize the parameters of two Degree of Freedom Proportional-Integral-Derivative Controller (2DOF-PID for controlling the load frequency in Automatic Generation Control (AGC for interconnected power system. The interconnected two area power system of non-reheat thermal power plants consisting of 2DOF-PID controller in each area has been considered for design and analysis. Firstly, the proposed approach has been implemented in the aforementioned standard test system and thereafter, the robustness of the system consisting 2DOF-PID controller optimized by proposed technique has been estimated using the sensitivity analysis for the same. The robustness of the system consisting of 2DOF-PID controller optimized by proposed scheme is examined by varying the parameters of standard test system, loading conditions during operation, size and location of the disturbances. The performance of the 2DOF-PID controller optimized by proposed approach has also been compared with recently published approaches in the literature. The simulation results show that the proposed hGWOPS optimized 2DOF-PID controller shows far better performance than recently published approaches in the literature in terms of dynamic response. The simulation results also show that system performances hardly change when the operating load condition and system parameters are changed by ±50% from their nominal values, i.e. the proposed controllers are quite robust for a wide range of the system parameters and operating load conditions from their nominal values.

  6. Correlative Fluorescence and Scanning Electron Microscopy of Labelled Core Fucosylated Glycans Using Cryosections Mounted on Carbon-Patterned Glass Slides.

    Science.gov (United States)

    Vancová, Marie; Nebesářová, Jana

    2015-01-01

    The aim of the study is co-localization of N-glycans with fucose attached to N-acetylglucosamine in α1,3 linkage, that belong to immunogenic carbohydrate epitopes in humans, and N-glycans with α1,6-core fucose typical for mammalian type of N-linked glycosylation. Both glycan epitopes were labelled in cryosections of salivary glands isolated from the tick Ixodes ricinus. Salivary glands secrete during feeding many bioactive molecules and influence both successful feeding and transmission of tick-borne pathogens. For accurate and reliable localization of labelled glycans in both fluorescence and scanning electron microscopes, we used carbon imprints of finder or indexed EM grids on glass slides. We discuss if the topographical images can provide information about labelled structures, the working setting of the field-emission scanning electron microscope and the influence of the detector selection (a below-the-lens Autrata improved YAG detector of back-scattered electrons; in-lens and conventional Everhart-Thornley detectors of secondary electrons) on the imaging of gold nanoparticles, quantum dots and osmium-stained membranes.

  7. Correlative Fluorescence and Scanning Electron Microscopy of Labelled Core Fucosylated Glycans Using Cryosections Mounted on Carbon-Patterned Glass Slides.

    Directory of Open Access Journals (Sweden)

    Marie Vancová

    Full Text Available The aim of the study is co-localization of N-glycans with fucose attached to N-acetylglucosamine in α1,3 linkage, that belong to immunogenic carbohydrate epitopes in humans, and N-glycans with α1,6-core fucose typical for mammalian type of N-linked glycosylation. Both glycan epitopes were labelled in cryosections of salivary glands isolated from the tick Ixodes ricinus. Salivary glands secrete during feeding many bioactive molecules and influence both successful feeding and transmission of tick-borne pathogens. For accurate and reliable localization of labelled glycans in both fluorescence and scanning electron microscopes, we used carbon imprints of finder or indexed EM grids on glass slides. We discuss if the topographical images can provide information about labelled structures, the working setting of the field-emission scanning electron microscope and the influence of the detector selection (a below-the-lens Autrata improved YAG detector of back-scattered electrons; in-lens and conventional Everhart-Thornley detectors of secondary electrons on the imaging of gold nanoparticles, quantum dots and osmium-stained membranes.

  8. Pattern matching

    NARCIS (Netherlands)

    A. Hak (Tony); J. Dul (Jan)

    2009-01-01

    textabstractPattern matching is comparing two patterns in order to determine whether they match (i.e., that they are the same) or do not match (i.e., that they differ). Pattern matching is the core procedure of theory-testing with cases. Testing consists of matching an “observed pattern” (a pattern

  9. Multi-voxel pattern analysis (MVPA reveals abnormal fMRI activity in both the core and extended face network in congenital prosopagnosia

    Directory of Open Access Journals (Sweden)

    Davide eRivolta

    2014-11-01

    Full Text Available The ability to identify faces is mediated by a network of cortical and subcortical brain regions in humans. It is still a matter of debate which regions represent the functional substrate of congenital prosopagnosia (CP, a condition characterized by a lifelong impairment in face recognition, and affecting around 2.5% of the general population. Here, we used functional Magnetic Resonance Imaging (fMRI to measure neural responses to faces, objects, bodies and body-parts in a group of seven CPs and ten healthy control participants. Using multi-voxel pattern analysis (MVPA of the fMRI data we demonstrate that neural activity within the core (i.e., occipital face area and fusiform face area and extended (i.e., anterior temporal cortex face regions in CPs showed reduced discriminability between faces and objects. Reduced differentiation between faces and objects in CP was also seen in the right parahippocampal cortex. In contrast, discriminability between faces and bodies/body-parts and objects and bodies/body-parts across the ventral visual system was typical in CPs. In addition to MVPA analysis, we also ran traditional mass-univariate analysis, which failed to show any group differences in face and object discriminability. In sum, these findings demonstrate (i face-object representations impairments in CP which encompass both the core and extended face regions, and (ii superior power of MVPA in detecting group differences.

  10. Multi-voxel pattern analysis (MVPA) reveals abnormal fMRI activity in both the "core" and "extended" face network in congenital prosopagnosia.

    Science.gov (United States)

    Rivolta, Davide; Woolgar, Alexandra; Palermo, Romina; Butko, Marina; Schmalzl, Laura; Williams, Mark A

    2014-01-01

    The ability to identify faces is mediated by a network of cortical and subcortical brain regions in humans. It is still a matter of debate which regions represent the functional substrate of congenital prosopagnosia (CP), a condition characterized by a lifelong impairment in face recognition, and affecting around 2.5% of the general population. Here, we used functional Magnetic Resonance Imaging (fMRI) to measure neural responses to faces, objects, bodies, and body-parts in a group of seven CPs and ten healthy control participants. Using multi-voxel pattern analysis (MVPA) of the fMRI data we demonstrate that neural activity within the "core" (i.e., occipital face area and fusiform face area) and "extended" (i.e., anterior temporal cortex) face regions in CPs showed reduced discriminability between faces and objects. Reduced differentiation between faces and objects in CP was also seen in the right parahippocampal cortex. In contrast, discriminability between faces and bodies/body-parts and objects and bodies/body-parts across the ventral visual system was typical in CPs. In addition to MVPA analysis, we also ran traditional mass-univariate analysis, which failed to show any group differences in face and object discriminability. In sum, these findings demonstrate (i) face-object representations impairments in CP which encompass both the "core" and "extended" face regions, and (ii) superior power of MVPA in detecting group differences.

  11. Foam patterns

    Science.gov (United States)

    Chaudhry, Anil R; Dzugan, Robert; Harrington, Richard M; Neece, Faurice D; Singh, Nipendra P; Westendorf, Travis

    2013-11-26

    A method of creating a foam pattern comprises mixing a polyol component and an isocyanate component to form a liquid mixture. The method further comprises placing a temporary core having a shape corresponding to a desired internal feature in a cavity of a mold and inserting the mixture into the cavity of the mold so that the mixture surrounds a portion of the temporary core. The method optionally further comprises using supporting pins made of foam to support the core in the mold cavity, with such pins becoming integral part of the pattern material simplifying subsequent processing. The method further comprises waiting for a predetermined time sufficient for a reaction from the mixture to form a foam pattern structure corresponding to the cavity of the mold, wherein the foam pattern structure encloses a portion of the temporary core and removing the temporary core from the pattern independent of chemical leaching.

  12. Variabilidad del patrón respiratorio durante la carga elástica inspiratoria Variability of breathing pattern during inspiratory elastic load

    Directory of Open Access Journals (Sweden)

    Carlos E. D´Negri

    2009-06-01

    Full Text Available La ventilación pulmonar en humanos tiene una variabilidad respiración a respiración no lineal, compleja y caótica. El objetivo del trabajo fue: caracterizar la variabilidad del patrón respiratorio en perros (n: 8 anestesiados respirando bajo carga elástica umbral (CEU inspiratoria (7 a 50 cm H2O. Con el flujo, presión traqueal y esofágica, se analizaron: tiempo inspiratorio (Ti, ritmo [tiempo espiratorio (Te; tiempo total (Ttot, y Ti/Ttot] e impulso central (Vt/Ti, variables relacionadas [volumen corriente (Vt y ventilación pulmonar (Ve]. Se determinaron: variabilidad grosera (varianzas, oscilaciones de baja frecuencia (análisis espectral y memoria a corto plazo (análisis de autocorrelación. La CEU produjo disminución de la varianza de medias en Te, Ttot, Vt y Vt/Ti (p In humans, lung ventilation exhibits breath-to-breath variability and dynamics that are nonlinear, complex and chaotic. Our objective was to characterize the breathing pattern variational activity in anesthetized dogs (n: 8 breathing through threshold inspiratory elastic load (7 to 50 cm H2O. Starting from flow signal and tracheal and esophageal pressures, we analyzed inspiratory time (Ti, timing (expiratory time, Te; total time, Ttot; and Ti/Ttot and central drive (Vt/Ti and variables related to it (tidal volume, Vt and pulmonary ventilation, Ve. We measured gross variability (variances, low frequency oscillations (spectral analysis, and short term memory (autocorrelation analysis. Loading decreased variance of the mean values of Te, Ttot, Vt and Vt/Ti (p < 0.05; the mean of variances for Ti/Ttot increased (p < 0.005 while it decreased for Vt and Vt/Ti (p < 0.05. In general, percent of data recordings with low frequency oscillations (OB% decreased (p < 0.02. During heavy load, timing parameters percent of data recordings with autocorrelations (AU% did not change, but Vt and its related parameters decreased their AU% (p < 0.005. There was a positive correlation (r: 0

  13. Effect of two Gulf Stream warm-core rings on distribution patterns of the diatom genus Nitzschia

    Science.gov (United States)

    Kaczmarska, Irena; Fryxell, Greta A.; Watkins, T. Phillip

    1986-11-01

    Two Gulf Stream warm-core rings (WCR) of different ages, 81-D and 82-H, were studied in early autumn of sequential years for the composition and distribution of the pennate diatom genus Nitzschia. The results indicate that species of this genus were dynamic and abundant elements of the diatom flora of the two WCR's, ranging from 33 to 82% of all diatoms in net samples and from 22 to 49% of all diatoms in cell numbers integrated throughout the water column from discrete water bottle samples. A new species, N. lodicula Kaczmarska, was present in both rings and is described. There were 29 species of Nitzschia in the net samples, with a mean of 16 and range of 8-22 in any one net haul. Two different types of assemblages characterized the two rings of different maturity. The first type was dominated by N. bicapitata Cleve and the second by N. bifurcata Kaczmarska & Licea. Nitzschia bifurcata was more abundant in the just-forming WCR 82-H, similar to the Gulf Stream sample collected the previous month before ring formation. N bicapitata was more abundant in the 3-month-old WCR 81-D, which may indicate influence of the water masses by coastal flora. Diverse assemblages, including representatives of the section Pseudonitzschia were found in the Sargasso Sea and in the Slope Water, but they differed markedly from each other. The assemblages of Nitzschia indicate that the Gulf Stream was probably a primary source of these WCR water masses. The changes in abundance in relation to other phytoplankton indicate that the genus is not opportunistic in taking advantage of overturns in the water column. Rather it survives well in stressful situations such as the High Velocity Region or during periods of ring overwash by Slope Wate, when other cell numbers are low. This study supports the concept of WCR as a flattening bowl or disc-shaped body that responds within hours to internal overturns and incorporation of Slope Water streamers.

  14. Expression pattern and core region analysis of AtMPK3 promoter in response to environmental stresses

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The protein kinase AtMPK3,a component of the MAP kinase cascade,plays an important role in stress signal transduction in plant cells. To clarify how AtMPK3 is regulated at the transcriptional level in response to various environmental factors, the 1016-bp promoter sequence upstream of the transcription start site of the AtMPK3 gene was isolated. Analyses of the promoter sequence using plant promoter databases revealed that the AtMPK3 promoter contains many potential cis-acting elements involved in environmental stress responses. We constructed four deletion mutants of the AtMPK3 promoter, and introduced the intact and truncated promoter sequences fused to the β-glucuronidase (GUS) gene into Arabidopsis. GUS histochemical staining and quantitative fluorometric GUS assays were performed to visualize and compare the expression patterns in response to different environmental stimuli. The region between-188 and-62 upstream of the transcription start site was identified as the essential DNA sequence of the AtMPK3 promoter for responses to drought, high salinity, low temperature, and wounding. These results advance our understanding of the molecular mechanisms controlling AtMPK3 expression in response to different environmental stimuli.

  15. A structured analysis of in vitro failure loads and failure modes of fiber, metal, and ceramic post-and-core systems.

    NARCIS (Netherlands)

    Fokkinga, W.A.; Kreulen, C.M.; Vallittu, P.K.; Creugers, N.H.J.

    2004-01-01

    PURPOSE: This study sought to aggregate literature data on in vitro failure loads and failure modes of prefabricated fiber-reinforced composite (FRC) post systems and to compare them to those of prefabricated metal, custom-cast, and ceramic post systems. MATERIALS AND METHODS: The literature was sea

  16. Suppression of the water splitting back reaction on GaN:ZnO photocatalysts loaded with core/shell cocatalysts, investigated using a μ-reactor

    DEFF Research Database (Denmark)

    Dionigi, Fabio; Vesborg, Peter Christian Kjærgaard; Pedersen, Thomas

    2012-01-01

    Using silicon-based l-reactors, we have studied the photocatalytic water splitting reaction and the catalytic back reaction on the same catalysts. GaN:ZnO without cocatalyst and loaded with Rh, Pt, Cr2O3/Rh, Cr2O3/Pt, and Rh–Cr mixed oxide has been tested for gas-phase photocatalytic water splitt...

  17. Quantify work load and muscle functional activation patterns in neck-shoulder muscles of female sewing machine operators using surface electromyogram

    Institute of Scientific and Technical Information of China (English)

    ZHANG Fei-ruo; HE Li-hua; WU Shan-shan; LI Jing-yun; YE Kang-pin; WANG Sheng

    2011-01-01

    Background Work-related musculoskeletal disorders (WMSDs) have high prevalence in sewing machine operators employed in the garment industry.Long work duration,sustained low level work and precise hand work are the main risk factors of neck-shoulder disorders for sewing machine operators.Surface electromyogram (sEMG) offers a valuable tool to determine muscle activity (internal exposure) and quantify muscular load (external exposure).During sustained and/or repetitive muscle contractions,typical changes of muscle fatigue in sEMG,as an increase in amplitude or a decrease as a shift in spectrum towards lower frequencies,can be observed.In this paper,we measured and quantified the muscle load and muscular activity patterns of neck-shoulder muscles in female sewing machine operators during sustained sewing machine operating tasks using sEMG.Methods A total of 18 healthy women sewing machine operators volunteered to participate in this study.Before their daily sewing machine operating task,we measured the maximal voluntary contractions (MVC) and 20%MVC of bilateral cervical erector spinae (CES) and upper trapezius (UT) respectively,then the sEMG signals of bilateral UT and CES were monitored and recorded continuously during 200 minutes of sustained sewing machine operating simultaneously which equals to 20 time windows with 10 minutes as one time window.After 200 minutes' work,we retest 20%MVC of four neck-shoulder muscles and recorded the sEMG signals.Linear analysis,including amplitude probability distribution frequency (APDF),amplitude analysis parameters such as roof mean square (RMS) and spectrum analysis parameter as median frequency (MF),were used to calculate and indicate muscle load and muscular activity of bilateral CES and UT.Results During 200 minutes of sewing machine operating,the median load for the left cervical erector spinae (LCES),right cervical erector spinae (RCES),left upper trapezius (LUT) and right upper trapezius (RUT) were 6.78%MVE,6.94

  18. Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans.

    Directory of Open Access Journals (Sweden)

    Dan Ziegler

    Full Text Available The autonomic nervous system (ANS plays an important role in regulating the metabolic homeostasis and controlling immune function. ANS alterations can be detected by reduced heart rate variability (HRV in conditions like diabetes and sepsis. We determined the effects of experimental conditions mimicking inflammation and hyperlipidemia on HRV and heart rate (HR in relation to the immune, metabolic, and hormonal responses resulting from these interventions. Sixteen lean healthy subjects received intravenous (i.v. low-dose endotoxin (lipopolysaccharide [LPS], i.v. fat, oral fat, and i.v. glycerol (control for 6 hours, during which immune, metabolic, hormonal, and five HRV parameters (pNN50, RMSSD, low-frequency (LF and high-frequency (HF power, and LF/HF ratio were monitored and energy metabolism and insulin sensitivity (M-value were assessed. LPS infusion induced an increase (AUC in HR and LF/HF ratio and decline in pNN50 and RMSSD, while oral fat resulted in elevated HR and a transient (hours 1-2 decrease in pNN50, RMSSD, and HF power. During LPS infusion, ΔIL-1ra levels and ΔIL-1ra and ΔIL-1ß gene expression correlated positively with ΔLF/HF ratio and inversely with ΔRMSSD. During oral fat intake, ΔGLP-1 tended to correlate positively with ΔHR and inversely with ΔpNN50 and ΔRMSSD. Following LPS infusion, lipid oxidation correlated positively with HR and inversely with pNN50 and RMSSD, whereas HRV was not related to M-value. In conclusion, suppression of vagal tone and sympathetic predominance during endotoxemia are linked to anti-inflammatory processes and lipid oxidation but not to insulin resistance, while weaker HRV changes in relation to the GLP-1 response are noted during oral fat load.ClinicalTrials.gov NCT01054989.

  19. Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans

    Science.gov (United States)

    Ziegler, Dan; Strom, Alexander; Strassburger, Klaus; Nowotny, Bettina; Zahiragic, Lejla; Nowotny, Peter J.; Carstensen-Kirberg, Maren; Herder, Christian; Szendroedi, Julia; Roden, Michael

    2015-01-01

    The autonomic nervous system (ANS) plays an important role in regulating the metabolic homeostasis and controlling immune function. ANS alterations can be detected by reduced heart rate variability (HRV) in conditions like diabetes and sepsis. We determined the effects of experimental conditions mimicking inflammation and hyperlipidemia on HRV and heart rate (HR) in relation to the immune, metabolic, and hormonal responses resulting from these interventions. Sixteen lean healthy subjects received intravenous (i.v.) low-dose endotoxin (lipopolysaccharide [LPS]), i.v. fat, oral fat, and i.v. glycerol (control) for 6 hours, during which immune, metabolic, hormonal, and five HRV parameters (pNN50, RMSSD, low-frequency (LF) and high-frequency (HF) power, and LF/HF ratio) were monitored and energy metabolism and insulin sensitivity (M-value) were assessed. LPS infusion induced an increase (AUC) in HR and LF/HF ratio and decline in pNN50 and RMSSD, while oral fat resulted in elevated HR and a transient (hours 1-2) decrease in pNN50, RMSSD, and HF power. During LPS infusion, ΔIL-1ra levels and ΔIL-1ra and ΔIL-1ß gene expression correlated positively with ΔLF/HF ratio and inversely with ΔRMSSD. During oral fat intake, ΔGLP-1 tended to correlate positively with ΔHR and inversely with ΔpNN50 and ΔRMSSD. Following LPS infusion, lipid oxidation correlated positively with HR and inversely with pNN50 and RMSSD, whereas HRV was not related to M-value. In conclusion, suppression of vagal tone and sympathetic predominance during endotoxemia are linked to anti-inflammatory processes and lipid oxidation but not to insulin resistance, while weaker HRV changes in relation to the GLP-1 response are noted during oral fat load. Trial Registration ClinicalTrials.gov NCT01054989 PMID:25893426

  20. Automated Classification and Correlation of Drill Cores using High-Resolution Hyperspectral Images and Supervised Pattern Classification Algorithms. Applications to Paleoseismology

    Science.gov (United States)

    Ragona, D. E.; Minster, B.; Rockwell, T.; Jasso, H.

    2006-12-01

    The standard methodology to describe, classify and correlate geologic materials in the field or lab rely on physical inspection of samples, sometimes with the assistance of conventional analytical techniques (e. g. XRD, microscopy, particle size analysis). This is commonly both time-consuming and inherently subjective. Many geological materials share identical visible properties (e.g. fine grained materials, alteration minerals) and therefore cannot be mapped using the human eye alone. Recent investigations have shown that ground- based hyperspectral imaging provides an effective method to study and digitally store stratigraphic and structural data from cores or field exposures. Neural networks and Naive Bayesian classifiers supply a variety of well-established techniques towards pattern recognition, especially for data examples with high- dimensionality input-outputs. In this poster, we present a new methodology for automatic mapping of sedimentary stratigraphy in the lab (drill cores, samples) or the field (outcrops, exposures) using short wave infrared (SWIR) hyperspectral images and these two supervised classification algorithms. High-spatial/spectral resolution data from large sediment samples (drill cores) from a paleoseismic excavation site were collected using a portable hyperspectral scanner with 245 continuous channels measured across the 960 to 2404 nm spectral range. The data were corrected for geometric and radiometric distortions and pre-processed to obtain reflectance at each pixel of the images. We built an example set using hundreds of reflectance spectra collected from the sediment core images. The examples were grouped into eight classes corresponding to materials found in the samples. We constructed two additional example sets by computing the 2-norm normalization, the derivative of the smoothed original reflectance examples. Each example set was divided into four subsets: training, training test, verification and validation. A multi

  1. Do Orientation-Based Differences in Nestbox Temperature Cause Differential Ectoparasite Load and Explain Patterns of Nest-Site Selection and Offspring Condition in Great Tits?

    Directory of Open Access Journals (Sweden)

    Anne E. Goodenough

    2011-01-01

    Full Text Available Nest ectoparasites have been linked previously to patterns of nest-site choice and breeding success in birds. Recent research has shown nestboxes facing south-southwest are occupied less frequently by great tits (Parus major than identical boxes facing other directions, and are associated with reduced offspring condition. Here, we investigate the hypothesis that these findings are due to ectoparasite load being directionally nonuniform, possibly because of nonuniformity in nestbox internal temperature. Nests contained, in order of prevalence, hen fleas (Ceratophyllus gallinae, haematophagous blowflies (Protocalliphora spp., biting lice (Ischnocera, and ticks/mites (Acari. Although southwest-facing nestboxes were significantly warmer than other boxes, there was no directional difference in total ectoparasite load or abundance of particular species. Similarly, there was no relationship between abundance of any ectoparasite species (either per-nest or per-chick and avian offspring condition determined using wing length or relative mass. We discuss several possible, nonmutually exclusive, explanations for this, including compensatory responses, costs of parasitism being transferred to parents, and condition-dependent effects.

  2. Prescribing pattern and WHO core prescribing indicators in post-operative patients of Gynaecology department of a tertiary care teaching hospital

    Directory of Open Access Journals (Sweden)

    Bhanu P. Kolasani

    2016-12-01

    Full Text Available Background: Prescription pattern analysis is an essential tool to provide an insight regarding the existing drug usage and to ensure rational drug therapy. Even though drugs used for gynecological disorders are one of the commonly used, they are least studied in terms of prescribing patterns. Hence the present study was planned to analyze the prescribing pattern and WHO core prescribing indicators among post-operative patients of Gynaecology department in our institute. Methods: A prospective observational study was conducted in 76 post-operative patients of Gynaecology department for a period of six months. Each prescription was analyzed for demographic data, total number and various categories of drugs prescribed, the percentage of individual drugs prescribed in each category, the dosage forms and the percentage of drugs prescribed by generic name, and from essential drug list were also analyzed. Results: A total of 990 medications were prescribed among which anti-microbial agents (32.52% were the most commonly prescribed category followed by analgesics (19.60% and Intravenous fluids (13.53%. Metronidazole (27.02% was the most commonly prescribed antimicrobial, Diclofenac (68.04% was the commonly prescribed analgesics and Ringer lactate (38.81% was the commonly prescribed Intravenous fluid. Most commonly prescribed antiulcer drug was ranitidine (75.0%, antiemetic was Ondansetron (76.39%. Majority of drugs (72.54% were prescribed by generic name. Average number of drugs per prescription was 13.03. Percentages of encounters with antibiotics were 32.52%. The percentage of drugs prescribed from the National List of Essential Medicines (NLEM was 82.16%. Injection (57.78% was the most common drug formulation. Conclusions: Antimicrobial agents and analgesics were the most commonly prescribed drugs. Prescription by generic name was high, usage of antibiotics and injections were also high and Poly-pharmacy was common, especially among antimicrobial

  3. Viral Load Pattern Among Hepatitis B Surface Antigen-positive Patients: Laboratory Perspective and Implications for Therapy

    Science.gov (United States)

    Iregbu, KC; Nwajiobi-Princewill, PI

    2016-01-01

    Background: Hepatitis B viral infection is an old medical problem with worldwide distribution. It is usually diagnosed using serologic methods. However, the decision as to which patient to treat or not remains challenging due to the poor sensitivity of serologic markers as prognostic or severity markers. Viral load (VL) determination using polymerase chain reaction techniques is a useful tool in decision-making. Aim: To determine the proportion of hepatitis B-positive patients who fall into different care groups based on the Society for Gastroenterology and Hepatology in Nigeria (SOGHIN) and National Institute for Health and Care Excellence guidelines, respectively, using result of hepatitis B virus (HBV) DNA determination. Materials and Methods: This is a retrospective and descriptive study. Data from all patients sent to the medical microbiology laboratory, National Hospital Abuja over a period of 28 months (November 2012 to February 2015) for hepatitis B DNA VL determinations were analyzed using Microsoft Excel 2010 (Microsoft Corporation, Redmond, WA, USA) and IBM SPSS version 20.0 (IBM SPSS, Inc., Chicago, IL, USA). Results: A total 666 patients, with mean age of 33.2 years, were tested. For those whose ages were known 36.2% (100/276) were below 30 years and 63.8% (176/276) 30 years and above. Exactly 66.7% (444/666) were males and the remaining 33.3% (222/666) were females. The VL of the patients varied from 20 to 1.7 × 108 IU/ml, with an average of 3.5 × 106 IU/ml. Around 76.1% (507/666) had measurable assay levels (20 − 1.7 × 108 IU/ml); 10.8% (76/666) had below 20 IU/ml and 3.8% (25/666) above 1.7 × 108 IU/ml. About 9.3% (62/666) had no detectable HBV DNA in their samples. About 46.8% (312/666) of the patients had levels between 20 and 2 × 103 IU/ml; 16.4% (109/666) had between 2001 and 2 × 104 IU/ml while 16.7% (111/666) had VL of between 20,001 and 1.7 × 108 IU/ml. Males tended to have detectable and higher VLs than females (P = 0

  4. Effect of Pd loading in Pd-Pt bimetallic catalysts doped into hollow core mesoporous shell carbon on performance of proton exchange membrane fuel cells

    Science.gov (United States)

    Fıçıcılar, Berker; Bayrakçeken, Ayşe; Eroğlu, İnci

    A significantly active Pd-Pt/carbon electrocatalyst for polymer electrolyte membrane fuel cells was synthesized by microwave irradiation using a hollow core mesoporous shell (HCMS) carbon as catalyst support that was prepared by template replication of core/shell spherical silica particles and two different carbon precursors. Pt/Pd percent weight ratios on carbon support were varied as 20/0, 15/5, 10/10, 5/15 to 0/20. As the average pore diameter of the carbon support was increased from 3.02 nm to 3.90 nm by changing the type of the carbon precursor, fuel cell performances of the HCMS carbon based Pd-Pt bimetallic catalysts were improved significantly.

  5. The construction, characterization, Hg(II)-sensing and removal behavior of magnetic core-shell nanospheres loaded with fluorescence "Off-On" probe.

    Science.gov (United States)

    Tan, Jun; Wei, Xiaoyan; Chen, Jie; Sun, Ping; Ouyang, Yuxia; Fan, Juhong; Liu, Rui

    2014-12-10

    The present paper constructed and discussed core-shell structured nanospheres grafted with rhodamine based probe for Hg(II) sensing and removal. Electron microscopy images, XRD curves, thermogravimetric analysis and N2 adsorption/desorption isotherms were used to identify the core-shell structure. The inner core consisted of superparamagnetic Fe3O4 nanoparticles, which made the nanocomposite magnetically removable. The outer shell was constructed with silica molecular sieve which provided large surface area and ordered tunnels for the sensing probe, accelerating analyte adsorption and transportation. The rhodamine based sensing probe emission increased with the increasing Hg(II) concentration, showing emission "Off-On" effect, which could be explained by the structural transformation from a non-emissive one to a highly emissive one. The influence from various metal ions and pH values was also investigated, which suggested this structural transformation could only be triggered by Hg(II), showing high selectivity and linear response. The Hg(II) sensing nanocomposite could be regenerated after usage. The response time was slightly compromised and could be further improved.

  6. Experimental Study on Sandwich Bridge Decks with GFRP Face Sheets and a Foam-Web Core Loaded under Two-Way Bending

    Directory of Open Access Journals (Sweden)

    Ruili Huo

    2015-01-01

    Full Text Available In recent years, the sandwich bridge decks with GFRP face sheets and light weight material core have been widely used in the world due to their advantages of low cost, high strength to weight ratios, and corrosion resisting. However, as the bridge decks, most of them are used in foot bridges rather than highway bridges because the ultimate bending strength and initial bending stiffness are relatively low. To address this issue and expand the scope of use, a simple and innovative sandwich bridge deck with GFRP face sheets and a foam-web core, manufactured by vacuum assisted resin infusion process, is developed. An experimental study was carried out to validate the effectiveness of this panel for increasing the ultimate bending strength and initial bending stiffness under two-way bending. The effects of face sheet thickness, foam density, web thickness, and web spacing on displacement ductility and energy dissipation were also investigated. Test results showed that, compared to the normal foam-core sandwich decks, an average approximately 657.1% increase in the ultimate bending strength can be achieved. Furthermore, the bending stiffness, displacement ductility, and energy dissipation can be enhanced by increasing web thickness, web height, and face sheet thickness or decreasing web spacing.

  7. Fuel loading experiments of IPEN/MB-01 reactor core; Experimento de carregamento do nucleo do reator IPEN/MB-01

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Alfredo; Angioletto, Elcio; Pasqualetto, Hertz; Moreira, Joao M.L.; Sabo, Marcos A.; Fuga, Rinaldo [Centro Tecnologico da Marinha em Sao Paulo (CTMSP), SP (Brazil). E-mail: ayabe@net.ipen.br; Jerez, Rogerio [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    2000-07-01

    IPEN/MB-01 is a critical assembly which reaches a first critically at November 1998, since then a several experiments have been conducted in order to validate and qualify the reactor Physics methodologies and codes. Recently, loading experiment was performed to determine the critical number of fuels rods using a multiplication inverse technique (1/M). The experiment can be considered as benchmark and contribute toward reactor physics methodologies, codes and basic nuclear data libraries validation qualification. (author)

  8. A combined interfacial and in-situ polymerization strategy to construct well-defined core-shell epoxy-containing SiO2-based microcapsules with high encapsulation loading, super thermal stability and nonpolar solvent tolerance

    Directory of Open Access Journals (Sweden)

    Yin Jia

    2016-10-01

    Full Text Available SiO2-based microcapsules containing hydrophobic molecules exhibited potential applications such as extrinsic self-healing, drug delivery, due to outstanding thermal and chemical stability of SiO2. However, to construct SiO2-based microcapsules with both high encapsulation loading and long-term structural stability is still a troublesome issue, limiting their further utilization. We herein design a single-batch route, a combined interfacial and in-situ polymerization strategy, to fabricate epoxy-containing SiO2-based microcapsules with both high encapsulation loading and long-term structural stability. The final SiO2-based microcapsules preserve high encapsulation loading of 85.7 wt% by controlling exclusively hydrolysis and condensed polymerization at oil/water interface in the initial interfacial polymerization step. In the subsequent in-situ polymerization step, the initial SiO2-based microcapsules as seeds could efficiently harvest SiO2 precursors and primary SiO2 particles to finely tune the SiO2 wall thickness, thereby enhancing long-term structural stability of the final SiO2-based microcapsules including high thermal stability with almost no any weight loss until 250°C, and strong tolerance against nonpolar solvents such as CCl4 with almost unchanged core-shell structure and unchanged core weight after immersing into strong solvents for up to 5 days. These SiO2-based microcapsules are extremely suited for processing them into anticorrosive coating in the presence of nonpolar solvents for self-healing application.

  9. Low-temperature CVD synthesis of patterned core-shell VO2@ZnO nanotetrapods and enhanced temperature-dependent field-emission properties

    Science.gov (United States)

    Yin, Haihong; Yu, Ke; Song, Changqing; Wang, Zhiliang; Zhu, Ziqiang

    2014-09-01

    VO2 nanostructures are attractive materials because of their reversible metal-insulator transition (MIT) and wide applications in devices. When they are used as field emitters, a new type of temperature-controlled field emission device can be fabricated. Vapor transport methods used to synthesize traditional VO2 nanostructures are energy-intensive, low yield, and produce simple morphology (quasi-1D) that exhibits substrate clamping; thus they are not suitable for field emission applications. To overcome these limitations, ZnO nanotetrapods were used as templates, and patterned core-shell VO2@ZnO nanotetrapods were successfully grown on an ITO/glass substrate via a low-temperature CVD synthesis. SEM, TEM, EDX, XPS analyses and X-ray diffraction revealed that the cores and shells of these nanotetrapods were single crystal wurtzite-type ZnO and polycrystalline VO2, respectively. The VO2@ZnO nanotetrapods show strongly MIT-related FE properties, the emission current density at low temperature is significantly enhanced in comparison with pure VO2 nanostructures, and the emission current density increased by about 20 times as the ambient temperature increased from 25 to 105 °C at a fixed field of 5 V μm-1. Although the VO2@ZnO nanotetrapods show a worse FE performance at low temperatures compared with pure ZnO nanotetrapods, the FE performance was substantially improved at high temperatures, which was attributed to the MIT-related band bending near the interface and the abrupt resistance change across the MIT.

  10. Development of core design and analyses technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Zee, Sung Quun; Lee, C. C.; Song, J. S. and others

    1999-03-01

    Integral reactors are developed for the applications such as sea water desalination, heat energy for various industries, and power sources for large container ships. In order to enhance the inherent and passive safety features, low power density concept is chosen for the integral reactor SMART. Moreover, ultra-longer cycle and boron-free operation concepts are reviewed for better plant economy and simple design of reactor system. Especially, boron-free operation concept brings about large difference in core configurations and reactivity controls from those of the existing large size commercial nuclear power plants and also causes many differences in the safety aspects. The ultimate objectives of this study include detailed core design of a integral reactor, development of the core design system and technology, and finally acquisition of the system design certificate. The goal of the first stage is the conceptual core design, that is, to establish the design bases and requirements suitable for the boron-free concept, to develop a core loading pattern, to analyze the nuclear, thermal and hydraulic characteristics of the core and to perform the core shielding design. Interface data for safety and performance analyses including fuel design data are produced for the relevant design analysis groups. Nuclear, thermal and hydraulic, shielding design and analysis code systems necessary for the core conceptual design are established through modification of the existing design tools and newly developed methodology and code modules. Core safety and performance can be improved by the technology development such as boron-free core optimization, advaned core monitoring and operational aid system. Feasiblity study on the improvement of the core protection and monitoring system will also contribute toward core safety and performance. Both the conceptual core design study and the related technology will provide concrete basis for the next design phase. This study will also

  11. Regulation of gene expression in the protozoan parasite Entamoeba invadens: identification of core promoter elements and promoters with stage-specific expression patterns.

    Science.gov (United States)

    Manna, Dipak; Ehrenkaufer, Gretchen M; Singh, Upinder

    2014-10-01

    Developmental switching between life-cycle stages is a common feature among many pathogenic organisms. Entamoeba histolytica is an important human pathogen and is a leading parasitic cause of death globally. During its life cycle, Entamoeba converts between cysts (essential for disease transmission) and trophozoites (responsible for tissue invasion). Despite being central to its biology, the triggers that are involved in the developmental pathways of this parasite are not well understood. In order to define the transcriptional network associated with stage conversion we used Entamoeba invadens which serves as a model system for Entamoeba developmental biology, and performed RNA sequencing at different developmental time points. In this study RNA-Seq data was utilised to define basal transcriptional control elements as well as to identify promoters which regulate stage-specific gene expression patterns. We discovered that the 5' and 3' untranslated regions of E. invadens genes are short, a median of 20 nucleotides (nt) and 26 nt respectively. Bioinformatics analysis of DNA sequences proximate to the start and stop codons identified two conserved motifs: (i) E. invadens Core Promoter Motif - GAAC-Like (EiCPM-GL) (GAACTACAAA), and (ii) E. invadens 3'-U-Rich Motif (Ei3'-URM) (TTTGTT) in the 5' and 3' flanking regions, respectively. Electrophoretic mobility shift assays demonstrated that both motifs specifically bind nuclear protein(s) from E. invadens trophozoites. Additionally, we identified select genes with stage-specific expression patterns and analysed the ability of each gene promoter to drive a luciferase reporter gene during the developmental cycle. This approach confirmed three trophozoite-specific, four encystation-specific and two excystation-specific promoters. This work lays the framework for use of stage-specific promoters to express proteins of interest in a particular life-cycle stage, adding to the molecular toolbox for genetic manipulation of E

  12. Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: Development, in-vitro appraisal and in-vivo studies.

    Science.gov (United States)

    El-Refaie, Wessam M; Elnaggar, Yosra S R; El-Massik, Magda A; Abdallah, Ossama Y

    2015-01-01

    Despite its effectiveness, curcumin (Curc) dermal delivery is handicapped by hydrophobicity, high metabolism and poor skin permeation. In this work, the potential of novel self-assembled nanogels, namely gel-core hyaluosome (GC-HS) to enhance Curc delivery to wound sites, enhance healing rate and decrease scar formation was evaluated. Curc-GC-HS were prepared using film hydration technique and evaluated regarding size, zeta potential (ZP), entrapment efficiency (% EE), and in vitro release. Structure elucidation was performed using light, polarizing and transmission electron microscopy (TEM). In-vivo burn-wound healing potential, skin deposition ability and histological study were evaluated using female Sprague Dawley rats. Curc-GC-HS were compared to conventional transfersomal gel (Curc-T-Pl gel), and other conventional gels. Curc-GC-HS showed nanosize (202.7 ± 0.66 nm), negative ZP (-33 ± 2.6 mV) and % EE (96.44 ± 1.29%). TEM revealed discrete vesicles with characteristic bilayer structure. Polarizing microscopy proposed liquid crystalline consistency. Burn-wound healing study showed that Curc-GC-HS was the only system exhibiting marked improvement at day 7 of treatment. At 11th day, Curc-GC-HS treated wounds showed almost normal skin with no scar confirmed by histological analysis. Curc-GC-HS showed five folds higher skin deposition compared to conventional Curc-T-Pl gel. To conclude, novel gel-core hyaluosomes elaborated are promising nanogels able to increase Curc skin penetration and dermal localization while protecting it against degradation. Future perspective encompasses assessing potential of novel nanocarrier for skin cancer therapy.

  13. The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load.

    Science.gov (United States)

    Willcox, D Craig; Willcox, Bradley J; Todoriki, Hidemi; Suzuki, Makoto

    2009-08-01

    Residents of Okinawa, the southernmost prefecture of Japan, are known for their long average life expectancy, high numbers of centenarians, and accompanying low risk of age-associated diseases. Much of the longevity advantage in Okinawa is thought to be related to a healthy lifestyle, particularly the traditional diet, which is low in calories yet nutritionally dense, especially with regard to phytonutrients in the form of antioxidants and flavonoids. Research suggests that diets associated with a reduced risk of chronic diseases are similar to the traditional Okinawan diet, that is, vegetable and fruit heavy (therefore phytonutrient and antioxidant rich) but reduced in meat, refined grains, saturated fat, sugar, salt, and full-fat dairy products. Many of the characteristics of the diet in Okinawa are shared with other healthy dietary patterns, such as the traditional Mediterranean diet or the modern DASH (Dietary Approaches to Stop Hypertension) diet. Features such as the low levels of saturated fat, high antioxidant intake, and low glycemic load in these diets are likely contributing to a decreased risk for cardiovascular disease, some cancers, and other chronic diseases through multiple mechanisms, including reduced oxidative stress. A comparison of the nutrient profiles of the three dietary patterns shows that the traditional Okinawan diet is the lowest in fat intake, particularly in terms of saturated fat, and highest in carbohydrate intake, in keeping with the very high intake of antioxidant-rich yet calorie-poor orange-yellow root vegetables, such as sweet potatoes, and green leafy vegetables. Deeper analyses of the individual components of the Okinawan diet reveal that many of the traditional foods, herbs, or spices consumed on a regular basis could be labeled "functional foods" and, indeed, are currently being explored for their potential health-enhancing properties.

  14. Combined geophysical surveys and coring data to investigate the pattern of the Watukosek fault system around the Lusi eruption site, Indonesia.

    Science.gov (United States)

    Husein, Alwi; Mazzini, Adriano; Lupi, Matteo; Mauri, Guillaume; Kemna, Andreas; Hadi, Soffian; Santosa, Bagus

    2016-04-01

    The Lusi mud eruption is located in the Sidoarjo area, Indonesia and is continuously erupting hot mud since its birth in May 2006. The Watukosek fault system originates from the neighboring Arjuno-Welirang volcanic complex extending towards the NE of Java. After the 27-06-2006 M 6.3 earthquake this fault system was reactivated and hosted numerous hot mud eruptions in the Sidoarjo area. Until now, no targeted investigations have been conducted to understand the geometry of the faults system crossing the Lusi eruption site. A comprehensive combined electrical resistivity and self-potential (SP) survey was performed in the 7 km2 area inside the Lusi embankment that had been built to contain the erupted mud and to prevent flooding of the surrounding roads and settlements. The goal of the geophysical survey is to map the near-surface occurrence of the Watukosek fault system upon which Lusi resides, delineate its spatial pattern, and monitor its development. We completed six lines of resistivity measurements using Wenner configuration and SP measurements using roll-along technique. Three subparallel lines were located to the north and to the south of the main crater. Each line was approximately W-E oriented extending for ~1.26 km. The surveyed regions consist of mud breccia (containing clayey-silty-sandy mixture with clast up to ~10 cm in size). The geophysical data have been complemented with a N-S oriented profile consisting of 6 cores (~30m long) drilled in the dry area inside the Lusi embankment. The resistivity data were inverted into 2-D resistivity images with a maximum penetration depth of almost 200 m. These images consistently reveal a region of about 300 m in width (between 30-90 m depth) characterized by anomalous resistivities, which are lower than the values observed in the surrounding area. The results of the SP data correspond well with the resistivity profiles in the anomalous parts, which suggests that their origin is related to fluid flow paths in the

  15. Differential neural activation patterns in patients with Parkinson's disease and freezing of gait in response to concurrent cognitive and motor load.

    Directory of Open Access Journals (Sweden)

    James M Shine

    Full Text Available Freezing of gait is a devastating symptom of Parkinson's disease (PD that is exacerbated by the processing of cognitive information whilst walking. To date, no studies have explored the neural correlates associated with increases in cognitive load whilst performing a motor task in patients with freezing. In this experiment, 14 PD patients with and 15 PD patients without freezing of gait underwent 3T fMRI while performing a virtual reality gait task. Directions to walk and stop were presented on the viewing screen as either direct cues or as more cognitively indirect pre-learned cues. Both groups showed a consistent pattern of BOLD response within the Cognitive Control Network during performance of the paradigm. However, a between group comparison revealed that those PD patients with freezing of gait were less able to recruit the bilateral anterior insula, ventral striatum and the pre-supplementary motor area, as well as the left subthalamic nucleus when responding to indirect cognitive cues whilst maintaining a motor output. These results suggest that PD patients with freezing of gait are unable to properly recruit specific cortical and subcortical regions within the Cognitive Control Network during the performance of simultaneous motor and cognitive functions.

  16. Differential Neural Activation Patterns in Patients with Parkinson's Disease and Freezing of Gait in Response to Concurrent Cognitive and Motor Load

    Science.gov (United States)

    Shine, James M.; Matar, Elie; Ward, Philip B.; Bolitho, Samuel J.; Pearson, Mark; Naismith, Sharon L.; Lewis, Simon J. G.

    2013-01-01

    Freezing of gait is a devastating symptom of Parkinson's disease (PD) that is exacerbated by the processing of cognitive information whilst walking. To date, no studies have explored the neural correlates associated with increases in cognitive load whilst performing a motor task in patients with freezing. In this experiment, 14 PD patients with and 15 PD patients without freezing of gait underwent 3T fMRI while performing a virtual reality gait task. Directions to walk and stop were presented on the viewing screen as either direct cues or as more cognitively indirect pre-learned cues. Both groups showed a consistent pattern of BOLD response within the Cognitive Control Network during performance of the paradigm. However, a between group comparison revealed that those PD patients with freezing of gait were less able to recruit the bilateral anterior insula, ventral striatum and the pre-supplementary motor area, as well as the left subthalamic nucleus when responding to indirect cognitive cues whilst maintaining a motor output. These results suggest that PD patients with freezing of gait are unable to properly recruit specific cortical and subcortical regions within the Cognitive Control Network during the performance of simultaneous motor and cognitive functions. PMID:23382821

  17. The Pattern of Brain Amyloid Load in Posterior Cortical Atrophy Using 18F-AV45: Is Amyloid the Principal Actor in the Disease

    Directory of Open Access Journals (Sweden)

    Emilie Beaufils

    2014-11-01

    Full Text Available Background: Posterior cortical atrophy (PCA is characterized by progressive higher-order visuoperceptual dysfunction and praxis declines. This syndrome is related to a number of underlying diseases, including, in most cases, Alzheimer's disease (AD. The aim of this study was to compare the amyloid load with 18F-AV45 positron emission tomography (PET between PCA and AD subjects. Methods: We performed 18F-AV45 PET, cerebrospinal fluid (CSF biomarker analysis and a neuropsychological assessment in 11 PCA patients and 12 AD patients. Results: The global and regional 18F-AV45 uptake was similar in the PCA and AD groups. No significant correlation was observed between global 18F-AV45 uptake and CSF biomarkers or between regional 18F-AV45 uptake and cognitive and affective symptoms. Conclusion: This 18F-AV45 PET amyloid imaging study showed no specific regional pattern of cortical 18F-AV45 binding in PCA patients. These results confirm that a distinct clinical phenotype in amnestic AD and PCA is not related to amyloid distribution.

  18. 多核处理器中任务调度与负载均衡的研究%Task Allocation and Load Balance on Multi-core Processors

    Institute of Scientific and Technical Information of China (English)

    彭蔓蔓; 黄亮

    2011-01-01

    针对多核处理器系统的特点,对任务分配及调度模型进行改进,提高各处理器相对均衡负载度,并在此基础上提出一种均衡种群遗传算法(BPGA).算法在任务节点的高度约束条件下,达到任务节点在处理核上随机分配,而任务节点数均衡分配.采用随机生成图法进行模拟实验,与其他算法相比,BPGA算法有更小的调度长度和较少的执行时间.%According to the characteristics of multi-core processor system, this paper improves task allocation and scheduling model to improve the relative balance of the load on the processors, and puts forward a balanced popula- tion genetic algorithm (BPGA). The algorithm under the constraints of the height of task nodes can allocate task nodes randomly and the number of nodes balanced on each processing core. The experiment used randomly generated DAG graph, compared with other algorithms, the BPGA has less makespan and less execution time.

  19. Enhancement of cytotoxic T lymphocyte activity by dendritic cells loaded with Tat-protein transduction domain-fused hepatitis B virus core antigen

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The protein transduction domain (PTD) of human immuno-deficiency virus-1-Tat protein has a unique potency to pen-etrate the cellular membranes. To synthesize the sequence of Tat-PTD and hepatitis B virus core antigen (HBcAg), we spliced these sequences and linked a fusion gene into the pMAL-c2x vector. The fusion proteins were purified by affin-ity chromatography and pulsed with bone marrow -derived den-dritic cells (DCs), and the transduction of recombinant pro-tein was detected by immunofluorescence antibody assay.Results showed that recombinant PTD-HBcAg could pen-etrate into DC cytoplasm while recombinant HBcAg was de-tected on the surface of cells. The percentage of DC surface molecules, such as CD80, CD86 and major histocompatibii-ity complex Ⅱ, and production of cytokine (IL-12pT0) induced by recombinant PTD-HBcAg were significantly higher than those induced by recombinant HBcAg or tumor necrosis fac-tor-α. DCs treated with PTD-HBcAg induced T cells to dif-ferentiate into specific cytotoxic T lymphocytes (CTLs) and enhanced the CTL killing response. In conclusion, the ex-pressed and purified PTD-HBcAg fusion protein could pen-etrate into cells through the plasma membrane, promote DC maturation, and enhance T cells response to generate HBcAg-specific CTLs efficiently.

  20. Tretinoin-loaded lipid-core nanocapsules decrease reactive oxygen species levels and improve bovine embryonic development during in vitro oocyte maturation.

    Science.gov (United States)

    Lucas, Caroline Gomes; Remião, Mariana Härter; Komninou, Eliza Rossi; Domingues, William Borges; Haas, Cristina; Leon, Priscila Marques Moura de; Campos, Vinicius Farias; Ourique, Aline; Guterres, Silvia S; Pohlmann, Adriana R; Basso, Andrea Cristina; Seixas, Fabiana Kömmling; Beck, Ruy Carlos Ruver; Collares, Tiago

    2015-12-01

    In vitro oocyte maturation (IVM) protocols can be improved by adding chemical supplements to the culture media. Tretinoin is considered an important retinoid in embryonic development and its association with lipid-core nanocapsules (TTN-LNC) represents an innovative way of improving its solubility, and chemical stability, and reducing its toxicity. The effects of supplementing IVM medium with TTN-LNC was evaluated by analyzing production of reactive oxygen species (ROS), S36-phosphorilated-p66Shc levels and caspase activity in early embryonic development, and expression of apoptosis and pluripotency genes in blastocysts. The lowest concentration tested (0.25μM) of TTN-LNC generated higher blastocyst rate, lower ROS production and S36-p66Shc amount. Additionally, expression of BAX and SHC1 were lower in both non-encapsulated tretinoin (TTN) and TTN-LNC-treated groups. Nanoencapsulation allowed the use of smaller concentrations of tretinoin to supplement IVM medium thus reducing toxic effects related with its use, decreasing ROS levels and apoptose frequency, and improving the blastocyst rates.

  1. Anti-Metastatic and Anti-Angiogenic Activities of Core-Shell SiO2@LDH Loaded with Etoposide in Non-Small Cell Lung Cancer.

    Science.gov (United States)

    Zhu, Yanjing; Zhu, Rongrong; Wang, Mei; Wu, Bin; He, Xiaolie; Qian, Yechang; Wang, Shilong

    2016-11-01

    Currently, nanoparticles have gained a great attention in the anti-tumor research area. However, to date, studies on the anti-metastasis action of core-shell SiO2@LDH (LDH: layered double hydroxide) nanoparticles remain untouched. Two emerging aspects considered are establishing research on the controlling delivery effect of SiO2@LDH combined with anti-cancer medicine from a new perspective. The fine properties synthetic SiO2@LDH-VP16 (VP16: etoposide) are practiced to exhibit the nanoparticle's suppression on migration and invasion of non-small cell lung cancer (NSCLC). Both in vitro and in vivo inspection shows that SiO2@LDH can help VP16 better function as an anti-metastasis agent. On the other hand, anti-angiogenic efficiency, co-localization, as well as western blot are investigated to explain the possible mechanism. A clear mergence of SiO2@LDH-VP16 and cytomembrane/microtubule may be observed from co-location images. Results offer evidence that SiO2@LDH-VP16 plays positions on cytomembrane and microtubules. It efficiently inhibits metastasis on NSCLC by reducing vascularization, and eliciting depression of the PI3K-AKT and FAK-Paxillin signaling pathways. SiO2@LDH-VP16, the overall particle morphology, and function on anti-metastasis and anti-angiogenic may be tuned to give new opportunities for novel strategies for cancer therapy.

  2. 大学英语精读教材核心词汇增长模式的比较研究%Comparative Study on Core Vocabulary Growth Pattern in College English Course Books

    Institute of Scientific and Technical Information of China (English)

    顾艳

    2012-01-01

    By adopting the vocabulary required by Ministry of Education of China as the core vocabulary and with the help of the corpus based on textbooks, single text core vocabulary occurrence rate and core vocabulary growth pattern are compared and studied on the basis of the four sets of college English course books. The research result shows that the occurrence rate of the core vocabulary in the textbook “New Horizon College English: Reading and Writing” is the highest, and the core vocabulary growth pattern in it is ideal.%以四套大学英语精读教材词汇为研究对象,以大学英语大纲词汇为核心词汇,通过建立教材语料库,比较研究教材中单篇核心词汇出现率以及教材的核心词汇增长模式。研究结果表明《新视野大学英语读写教程》教材中核心词汇出现率最高,核心词汇增长模式最为理想。

  3. Indocyanine Green-Loaded Silver Nanoparticle@Polyaniline Core/Shell Theranostic Nanocomposites for Photoacoustic/Near-Infrared Fluorescence Imaging-Guided and Single-Light-Triggered Photothermal and Photodynamic Therapy.

    Science.gov (United States)

    Tan, Xiaoxiao; Wang, Jinping; Pang, Xiaojuan; Liu, Li; Sun, Qi; You, Qing; Tan, Fengping; Li, Nan

    2016-12-28

    Photoacoustic (PA)/near-infrared fluorescence (NIRF) dual-modal imaging-guided phototherapy has been wide explored very recently. However, the development of high-efficiency and simplified-performed theranostic system for amplifying imaging-guided photothermal therapy/photodynamic therapy (PTT/PDT) is still a great challenge. Herein, a single-light-triggered indocyanine green (ICG)-loaded PEGylation silver nanoparticle core/polyaniline shell (Ag@PANI) nanocomposites (ICG-Ag@PANI) for PA/NIRF imaging-guided enhanced PTT/PDT synergistic effect has been successfully constructed. In this study, the synthesized Ag@PANI nanocomposites are utilized not only as the promising photothermal agent but also as potential nanovehicles for loading photosensitizer ICG via π-π stacking and hydrophobic interaction. The as-prepared ICG-Ag@PANI possesses many superior properties such as strong optical absorption in the near-infrared (NIR) region, enhanced photostability of ICG, as well as outstanding NIR laser-induced local hyperthermia and reactive oxygen species (ROS) generation. In the in vivo study, PA/NIRF dual-modal imaging confirms the accumulation and distribution of ICG-Ag@PANI in the tumor region via enhanced permeability and retention (EPR) effect. Moreover, the PTT effect of ICG-Ag@PANI rapidly raised the tumor temperature to 56.8 °C within 5 min. It is also demonstrated that the cytotoxic ROS generation ability of ICG is well maintained after being loaded onto Ag@PANI nanocomposites. Remarkably, in comparison with PTT or PDT alone, the single 808 nm NIR laser-triggered combined PTT/PDT therapy exhibits enhanced HeLa cells lethality in vitro and tumor growth inhibition in vivo.

  4. Patterns of distribution of sound-scattering zooplankton in warm- and cold-core eddies in the Gulf of Mexico, from a narrowband acoustic Doppler current profiler survey

    Science.gov (United States)

    Zimmerman, Robert A.; Biggs, Douglas C.

    1999-03-01

    The acoustic backscatter intensity (ABI) reflected from epipelagic zooplankton communities in the central Gulf of Mexico was measured during June 1995 with a vessel-mounted, narrowband-153-kHz acoustic Doppler current profiler (ADCP). Horizontal and vertical variations in ABI were documented in three kinds of mesoscale hydrographic features commonly found in the Gulf of Mexico: the warm-core Loop Current (LC), a warm-core Loop Current eddy (LCE), and a cold-core region that separated the two warm-core features. Since new nitrogen domes close to surface waters in cold-core features whereas surface waters of warm-core features are nutrient depleted, the cold-core region was expected to have higher biological stocks as a result of locally higher primary production. Both ABI and net tow data confirmed that the cold-core region was in fact a zone of local aggregation of zooplankton and micronekton. During both day and night, ABI when integrated for the upper 50 and 100 m in the cold-core region was significantly greater than in the LC or in the LCE, and ABI was positively correlated with standing stock biomass taken by the net tows. Further investigations into the biological differences between Gulf of Mexico divergence and convergence regimes are warranted, and the ADCP will be a useful tool for examination of the distribution of sound scatterers in such features.

  5. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in a...

  6. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in...

  7. Fuzzy Pattern Recognition Technique for Moving Train Loads Identification According to Bridge Responses%根据响应识别桥上列车荷载的模糊模式识别方法

    Institute of Scientific and Technical Information of China (English)

    瞿伟廉; 王仪

    2011-01-01

    为准确快速地获知通过桥梁的列车荷载大小,将模糊模式识别的方法引入桥梁列车荷载识别问题,将列车荷载识别过程转变为与列车荷载响应标准模式库的模式匹配过程.采用数值分析方法,分别基于桥梁位移、速度和加速度响应对鄱阳湖连续钢桁桥列车荷载进行识别,结果表明利用加速度响应获得的识别结果精度要明显好于采用位移和速度响应获得的识别精度,同时通过对在噪声干扰下列车荷载识别结果的分析,验证论文所述方法对桥上移动列车荷载进行识别的可行性和准确性.%A fuzzy pattern recognition method is presented to realize the accurate and efficient identification of moving train loads according to bridge responses. The moving loads identification process is translated into a procedure of pattern match with those in the load-response pattern library. Numerical simulations based on the responses of displacement,velocity and acceleration are carried out for Poyang Lake continuous steel-truss girder, and the train loads on the bridge are identified. It is shown that the results of identification by using acceleration response have higher accuracy than those obtained by using the others. Through the identification of the train loads with noise disturbance, this method is proved to be feasible and accurate for moving train loads identification.

  8. Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?

    Science.gov (United States)

    Cánepa, Camila; Salido, Jimena; Ruggieri, Matías; Fraile, Sindy; Pataccini, Gabriela; Berini, Carolina; Biglione, Mirna

    2015-10-28

    indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas. (a) to define the prevalence of indeterminate WB among different populations from Argentina; (b) to evaluate if low proviral load (PVL) is associated with indeterminate WB profiles; and (c) to describe mutations in LTR and tax sequence of these cases. Among 2031 samples, 294 were reactive by screening. Of them, 48 (16.3%) were WB indeterminate and of those 15 (31.3%) were PCR+. Quantitative real-time PCR (qPCR) was performed to 52 HTLV-1+ samples, classified as Group 1 (G1): 25 WB+ samples from individuals with pathologies; Group 2 (G2): 18 WB+ samples from asymptomatic carriers (AC); and Group 3 (G3): 9 seroindeterminate samples from AC. Median PVL was 4.78, 2.38, and 0.15 HTLV-1 copies/100 PBMCs, respectively; a significant difference (p=0.003) was observed. Age and sex were associated with PVL in G1 and G2, respectively. Mutations in the distal and central regions of Tax Responsive Elements (TRE) 1 and 2 of G3 were observed, though not associated with PVL.The 8403A>G mutation of the distal region, previously related to high PVL, was absent in G3 but present in 50% of WB+ samples (p = 0.03). indeterminate WB results confirmed later as HTLV-1 positive may be associated with low PVL levels. Mutations in LTR and tax are described; their functional relevance remains to be determined.

  9. Cumulative viral load and virologic decay patterns after antiretroviral therapy in HIV-infected subjects influence CD4 recovery and AIDS.

    Directory of Open Access Journals (Sweden)

    Vincent C Marconi

    Full Text Available BACKGROUND: The impact of viral load (VL decay and cumulative VL on CD4 recovery and AIDS after highly-active antiretroviral therapy (HAART is unknown. METHODS AND FINDINGS: Three virologic kinetic parameters (first year and overall exponential VL decay constants, and first year VL slope and cumulative VL during HAART were estimated for 2,278 patients who initiated HAART in the U.S. Military HIV Natural History Study. CD4 and VL trajectories were computed using linear and nonlinear Generalized Estimating Equations models. Multivariate Poisson and linear regression models were used to determine associations of VL parameters with CD4 recovery, adjusted for factors known to correlate with immune recovery. Cumulative VL higher than the sample median was independently associated with an increased risk of AIDS (relative risk 2.38, 95% confidence interval 1.56-3.62, p<0.001. Among patients with VL suppression, first year VL decay and slope were independent predictors of early CD4 recovery (p = 0.001 and overall gain (p<0.05. Despite VL suppression, those with slow decay during the first year of HAART as well as during the entire therapy period (overall, in general, gained less CD4 cells compared to the other subjects (133 vs. 195.4 cells/µL; p = 0.001 even after adjusting for potential confounders. CONCLUSIONS: In a cohort with free access to healthcare, independent of established predictors of AIDS and CD4 recovery during HAART, cumulative VL and virologic decay patterns were associated with AIDS and distinct aspects of CD4 reconstitution.

  10. Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?

    Directory of Open Access Journals (Sweden)

    Camila Cánepa

    2015-10-01

    Full Text Available Background: indeterminate Western blot (WB patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1 infection, even in non-endemic areas. Objectives: (a to define the prevalence of indeterminate WB among different populations from Argentina; (b to evaluate if low proviral load (PVL is associated with indeterminate WB profiles; and (c to describe mutations in LTR and tax sequence of these cases. Results: Among 2031 samples, 294 were reactive by screening. Of them, 48 (16.3% were WB indeterminate and of those 15 (31.3% were PCR+. Quantitative real-time PCR (qPCR was performed to 52 HTLV-1+ samples, classified as Group 1 (G1: 25 WB+ samples from individuals with pathologies; Group 2 (G2: 18 WB+ samples from asymptomatic carriers (AC; and Group 3 (G3: 9 seroindeterminate samples from AC. Median PVL was 4.78, 2.38, and 0.15 HTLV-1 copies/100 PBMCs, respectively; a significant difference (p=0.003 was observed. Age and sex were associated with PVL in G1 and G2, respectively. Mutations in the distal and central regions of Tax Responsive Elements (TRE 1 and 2 of G3 were observed, though not associated with PVL.The 8403A>G mutation of the distal region, previously related to high PVL, was absent in G3 but present in 50% of WB+ samples (p = 0.03. Conclusions: indeterminateWBresults confirmed later as HTLV-1 positive may be associated with low PVL levels. Mutations in LTR and tax are described; their functional relevance remains to be determined.

  11. Effects of Radial Reflector Composition on Core Reactivity and Peak Power

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Yoon; Lee, Kyung Hoon; Song, Jae Seung

    2007-10-15

    The effects of radial SA-240 alloy shroud on core reactivity and peak power are evaluated. The existence of radial SA-240 alloy shroud makes reflector water volume decrease, so the thermal absorption cross section of radial reflector is lower than without SA-240 alloy shroud case. Finally, the cycle length is increased from 788 EFPD to 845 EFPD and the peak power is decreased from 1.66 to 1.49. In the case of without SA-240 alloy shroud, a new core loading pattern search has been performed. For the guarantee of the same equivalent cycle length of with SA-240 alloy shroud case, the enrichment of U-235 should be increased from 4.22 w/o to 4.68 w/o. The nuclear key safety parameters of new core loading pattern have been calculated and recorded for the future.

  12. 核壳型载药微球的制备及其释药性能研究%Drug loaded microparticles with core-shell structure and their drug release property

    Institute of Scientific and Technical Information of China (English)

    聂光庭; 段泰炜; 容建华

    2013-01-01

    Core-shell drug loaded microspheres were prepared by the layer-by-layer self-assembly technique in which sodium polystyrene sulionate (PSS), poly(diallyl dimethyl ammonium chloride) (PDDA) and clay parti-cles (laponite) were alternatively adsorbed on the calcium carbonate (CaCO3) template particles. PSS was also used in the preparation of CaCO3 template to control its structure. Ibuprofen (IBU) as model drug was then loaded in the pore of CaCO3 through physical absorption. At last the polyelectrolytes and/or laponite particles were assembly on the drug loaded CaCO3 particles to block the drug releasing. The laponite could be dispersed into monolayer round sheet with the diameter and thickness about 25nm and 1nm respectively in the water, which used in the shell of microspheres here to promote the properties of drug releasing. The morphology, structure and drug release property of the microspheres were characterized by the scanning electron microscope (SEM), the transmission electron microscope (TEM), zeta potential analyzer, X-ray diffraction (XRD), Fou-rier transform infrared spectra (FT-IR) and ultraviolet spectrophotometer (UV). The results showed that PSS played an important role in the synthesis of CaCO3 microspheres, by which not only the spherical morphology was controlled, but also its crystal type was changed from calcite to vaterite. The IBU loading in CaCO3 could reach 28. 6mg/g. The thin shell of polyelectrolyte or polyelectrolyte/laponite could be formed on the surface of CaCO3 by layer-by-layer assembly, which was verified by the polyelectrolyte/laponite microcapsules obtained after removing the core of CaCO3. The result of cumulative drug releasing showed that the shell of polyelectro-lyte and laponite particles could effectively extend the time of drug releasing.%以聚苯乙烯磺酸钠(PSS)掺杂CaCO3微球为模板,利用逐层(LBL)自组装技术将聚二烯丙基二甲基氯化铵(PDDA)和锂藻土(Laponite)组装到微球表面,得到了核

  13. Pattern matching

    OpenAIRE

    Hak, Tony; Dul, Jan

    2009-01-01

    textabstractPattern matching is comparing two patterns in order to determine whether they match (i.e., that they are the same) or do not match (i.e., that they differ). Pattern matching is the core procedure of theory-testing with cases. Testing consists of matching an “observed pattern” (a pattern of measured values) with an “expected pattern” (a hypothesis), and deciding whether these patterns match (resulting in a confirmation of the hypothesis) or do not match (resulting in a disconfirmat...

  14. Three-dimensional fabrication and characterisation of core-shell nano-columns using electron beam patterning of Ge-doped SiO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Gontard, Lionel C. [Instituto de Ciencia de Materiales de Sevilla (CSIC), 41092 Sevilla (Spain); Jinschek, Joerg R. [FEI Europe, Achtseweg Noord 5, 5600 KA Eindhoven (Netherlands); Ou Haiyan [Department of Photonics, Technical University of Denmark, DK-2800 Kongens Lyngby (Denmark); Verbeeck, Jo [EMAT, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp (Belgium); Dunin-Borkowski, Rafal E. [Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons and Peter Gruenberg Institute, Forschungszentrum Juelich, D-52425 Juelich (Germany)

    2012-06-25

    A focused electron beam in a scanning transmission electron microscope (STEM) is used to create arrays of core-shell structures in a specimen of amorphous SiO{sub 2} doped with Ge. The same electron microscope is then used to measure the changes that occurred in the specimen in three dimensions using electron tomography. The results show that transformations in insulators that have been subjected to intense irradiation using charged particles can be studied directly in three dimensions. The fabricated structures include core-shell nano-columns, sputtered regions, voids, and clusters.

  15. Ice cores

    DEFF Research Database (Denmark)

    Svensson, Anders

    2014-01-01

    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...

  16. Ice cores

    DEFF Research Database (Denmark)

    Svensson, Anders

    2014-01-01

    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...

  17. Catalyst with core-shell structure and low platinum loading:A review on their design,preparation and the effects of core structure and composition on catalyst performance%核壳结构低铂催化剂:设计、制备及核的组成及结构的影响

    Institute of Scientific and Technical Information of China (English)

    陈丹; 舒婷; 廖世军

    2013-01-01

      核壳结构低铂催化剂具有可大幅提高贵金属铂的利用率、有效降低燃料电池铂使用量及成本的重要特点,被誉为质子交换膜燃料电池大规模商业化的希望之所在,相关研究已成为燃料电池领域最为热门的课题之一。本文综述了近年来提出的各种高性能核壳结构催化剂的设计思路及新型制备技术,介绍了各种不同组成和结构的核壳结构催化剂性能及特点以及在核壳结构催化剂表征技术方面的最新进展。最后对核壳结构催化剂制备技术的发展和应用前景进行了展望:通过发展或改进制备工艺,制备各种形貌组成可控以及高活性低Pt载量的核壳结构催化剂,有望实现质子交换膜燃料电池商业化。%Core-shell structured catalyst is recognized as a promising catalyst for large scale commercialization of PEM fuel cells,as it can significantly enhance the utilization of precious platinum,reduce the amount of platinum catalyst used and sharply save the cost of fuel cells. Investigation on core-shell structured catalyst is becoming one of the hottest topics in fuel cell field. This paper is aimed to introduce the latest developments and achievements on the design,preparation technology,and investigations on the effects of core composition and structure on the performance of core-shell structured catalyst,as well as the latest development of characterization techniques for core-shell structure. Furthermore,prospects for the development of new preparation technology and the application of this type catalyst are discussed. Research directions are suggested to advance the future works in this field,i.e.,it is expected to achieve the commercialization of proton exchange membrane fuel cell through the development or improvement of the preparation process of the core-shell structured catalysts with controllability on morphology,high activity and low Pt platinum loading.

  18. Three-dimensional fabrication and characterisation of core-shell nano-columns using electron beam patterning of Ge-doped SiO2

    DEFF Research Database (Denmark)

    Gontard, Lionel C.; Jinschek, Joerg R.; Ou, Haiyan;

    2012-01-01

    A focused electron beam in a scanning transmission electron microscope (STEM) is used to create arrays of core-shell structures in a specimen of amorphous SiO2 doped with Ge. The same electron microscope is then used to measure the changes that occurred in the specimen in three dimensions using e...

  19. An upgraded Monju core concept for demonstration of future FBR technologies

    Energy Technology Data Exchange (ETDEWEB)

    Kinjo, Hidehito; Nishi, Hiroshi [Japan Nuclear Cycle Development Inst., Tsuruga Head Office, Tsuruga, Fukui (Japan); Kageyama, Takeshi [Nuclear Energy System Inc., Tokyo (Japan)

    2002-03-01

    Upgrading of the Monju core is planned for increased fuel burn-up and longer operating cycles. It is also proposed that this upgraded core be utilized as an irradiation test bed to demonstrate the performance of the advanced fuel subassembly concepts proposed by the 'Feasibility Study on Commercialized Fast Reactor Cycle Systems (FS)'. A conceptual design study has been performed at the International Cooperation and Technology Development Center to investigate the feasibility of demonstrating the commercial FBR fuel subassembly concept proposed in the first phase of the above study. The specification of the subassembly with an increased fuel pin diameter irradiated in Monju will have fewer pins than the full-scale commercial subassembly due to the smaller wrapper diameter. The effects of loading different numbers of commercial-type subassemblies in different patterns on the major core characteristics have been evaluated along with the reactivity parameters related to core safety. The results show that in a core loading scheme with up to 30 subassemblies around the core center, the target discharge burn-up of 150 GWd/t could be achieved in 5 years, without causing significant drawbacks on the core neutronics and safety aspects, such as the maximum linear power, burnup reactivity, control-rod worth and Doppler reactivity. Thus the feasibility of demonstrating the performance of the commercial FBR fuel designs of this type in the upgraded core has been confirmed. (author)

  20. In-core fuel management for pebble-bed reactors

    Energy Technology Data Exchange (ETDEWEB)

    Milian Perez, Daniel; Rodriguez Garcia, Lorena; Garcia Hernandez, Carlos; Milian Lorenzo, Daniel, E-mail: dperez@instec.cu, E-mail: cgh@instec.cu, E-mail: dmilian@instec.cu [Higher Institute of Technologies and Applied Sciences, Havana (Cuba); Velasco, Abanades, E-mail: abanades@etsii.upm.es [Department of Simulation of Thermo Energy Systems, Polytechnic University of Madrid (Spain)

    2013-07-01

    In this paper a calculation procedure to reduce the power peak in the core of a Very High Temperature pebble bed Reactor is presented. This procedure combines the fuel depletion and the neutronic behavior of the fuel in the reactor core, modeling once-through-then-out cycles as well as cycles in which pebbles are recirculated through the core an arbitrary number of times, obtaining the asymptotic fuel-loading pattern. The procedure consists in several coupled computational codes, which are used iteratively until convergence is reached. The utilization of the MCNPX 2.6e, as one of these computational codes, is validated through the calculation of benchmarks announced by IAEA (IAEA-TECDOC-1249, 2001). To complete the verification of the calculation procedure a base case described in (Annals of Nuclear Energy 29 (2002) 1345-1364), was performed. The procedure has been applied to a model of Pebble Bed Modular Reactor (200 MW) design. (author)

  1. Load Measurements

    DEFF Research Database (Denmark)

    Kock, Carsten Weber; Vesth, Allan

    The report describes Load measurements carried out on a given wind turbine. The aim of the measurement program regarding the loads on the turbine is to verify the basic characteristics of the wind turbine and loads on the blades, the rotor and the tower, using [Ref 1], [Ref2] and [Ref 3]. Regarding...... the fatigue loads, the rotor, blades and tower moments are presented. The fatigue loads are evaluated using rainflow counting described in detail in Ref. [1]. The 1Hz equivalent load ranges are calculated at different wind speeds. All information regarding the instrumentation is collected in [ref 4] and [ref...

  2. Variable EBV DNA Load Distributions and Heterogeneous EBV mRNA Expression Patterns in the Circulation of Solid Organ versus Stem Cell Transplant Recipients

    NARCIS (Netherlands)

    Greijer, A. E.; Stevens, S. J.; Verkuijlen, S. A.; Juwana, H.; Fleig, S. C.; Verschuuren, E. A.; Hepkema, B. G.; Cornelissen, J. J.; Brooimans, R. A.; Verdonck, L. F.; Middeldorp, J. M.

    2012-01-01

    Epstein-Barr virus (EBV) driven post-transplant lymphoproliferative disease (PTLD) is a heterogeneous and potentially life-threatening condition. Early identification of aberrant EBV activity may prevent progression to B-cell lymphoma. We measured EBV DNA load and RNA profiles in plasma and cellular

  3. Variable EBV DNA load distributions and heterogeneous EBV mRNA expression patterns in the circulation of solid organ versus stem cell transplant recipients

    NARCIS (Netherlands)

    A.E. Greijer; S.J. Stevens; S.A. Verkuijlen; H. Juwana; S.C. Fleig; E.A. Verschuuren; B.G. Hepkema (Bouke); J.J. Cornelissen (Jan); R.A. Brooimans (Rik); L.F. Verdonck (Leo); J.M. Middeldorp (Jaap)

    2012-01-01

    textabstractEpstein-Barr virus (EBV) driven post-transplant lymphoproliferative disease (PTLD) is a heterogeneous and potentially life-threatening condition. Early identification of aberrant EBV activity may prevent progression to B-cell lymphoma. We measured EBV DNA load and RNA profiles in plasma

  4. Fast reactor core concepts to improve transmutation efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Fujimura, Koji; Kawashima, Katsuyuki [Hitachi Research Laboratory, Hitachi, Ltd., 7-1-1, Omika-cho, Hitachi-shi, Ibaraki, 319-1221 Japan (Japan); Itooka, Satoshi [Hitachi-GE Nuclear Energy, Ltd., 3-1-1, Saiwai-cho, Hitachi-shi, Ibaraki, 317-0073 Japan (Japan)

    2015-12-31

    Fast Reactor (FR) core concepts to improve transmutation efficiency were conducted. A heterogeneous MA loaded core was designed based on the 1000MWe-ABR breakeven core. The heterogeneous MA loaded core with Zr-H loaded moderated targets had a better transmutation performance than the MA homogeneous loaded core. The annular pellet rod design was proposed as one of the possible design options for the MA target. It was shown that using annular pellet MA rods mitigates the self-shielding effect in the moderated target so as to enhance the transmutation rate.

  5. Load Measurements

    DEFF Research Database (Denmark)

    Vesth, Allan; Kock, Carsten Weber

    The report describes Load measurements carried out on a given wind turbine. The aim of the measurement program regarding the loads on the turbine is to verify the basic characteristics of the wind turbine and loads on the blades, the rotor and the tower, using [Ref 1], [Ref2] and [Ref 3]. Regardi...

  6. Load Measurements

    DEFF Research Database (Denmark)

    Kock, Carsten Weber; Vesth, Allan

    The report describes Load measurements carried out on a given wind turbine. The aim of the measurement program regarding the loads on the turbine is to verify the basic characteristics of the wind turbine and loads on the blades, the rotor and the tower, using [Ref 1], [Ref2] and [Ref 3]. Regarding...

  7. Changes in distributional patterns of plaice Pleuronectes platessa in the central and eastern North Sea; do declining nutrient loadings play a role?

    DEFF Research Database (Denmark)

    Støttrup, Josianne Gatt; Munk, Peter; Kodama, Masashi

    2017-01-01

    . For the same time period available time series data on nutrient conditions in the coastalNorth Sea area showthat the freshwater nitrogen loading has decreased by about 50%. While nutrient concentrations in the ambient environment have been shown to influence growth in juvenile plaice through influence...... sandbank in a shallowoffshore area of the North Sea. The Dogger Bank, was used as a reference location assuming this area has been less influenced from coastal eutrophication but similar regional climate conditions, and here we found no changes in the abundances of juvenile plaice. The increase in the use...... of offshore habitats as nursery areas by juvenile plaice in the North Sea appears not related to water depth per se but driven by specific processes dominating in near-shore areas and may be related to changes in nutrient loadings. This point to the importance of separating more general depth-related factors...

  8. Biomolecular Cell-Signaling Mechanisms and Dental Implants: A Review on the Regulatory Molecular Biologic Patterns Under Functional and Immediate Loading.

    Science.gov (United States)

    Romanos, Georgios E

    2016-01-01

    Bone tissue adapts its structure and mass to the stresses of mechanical loading. The purpose of this review article was to summarize recent advances on cell signaling relating to the phenomenon of bone remodeling, focused on bone ossification and healing at the interface of dental implants and bone under loading conditions. When a dental implant is placed within an osteotomy, osteocytes, osteoblasts, and osteoclasts are all present. As functional loads are imposed, the remodeling processes adapt the peri-implant bony tissues to mechanical stimuli over time and reestablish a steady state. Based on the current literature, this article demonstrates fundamental information to these remodeling processes, such as the conversion of mechanical cues to electrical or biochemical signals. Multiple intracellular signals are involved in cellular mechanotransduction; the two Wnt signaling pathways (the canonical, β-catenin-dependent and the noncanonical, β-catenin-independent Wnt pathway) are particularly significant. Knowledge of how these molecular signaling pathways are translated into intracellular signals that regulate cell behavior may provide new therapeutic approaches to enhancing osteogenesis, especially around implants with immediate function or placed in areas of poor bone quality. New knowledge about the primary cilia as an organelle and bone cellular mechanosensor is critical for endochondral ossification and proper signal transduction. Other mechanisms, such as the expression of sclerostin as a negative regulator of bone formation (due to deactivation of the Wnt receptor) and downregulation of sclerostin under loading conditions, also present new understanding of the cellular and pericellular mechanics of bone. The complexity of the cell signaling pathways and the mechanisms involved in the mechanoregulation of the bone formation provide new technologies and perspectives for mechanically induced cellular response. Future novel therapeutic approaches based on the

  9. Variable EBV DNA Load Distributions and Heterogeneous EBV mRNA Expression Patterns in the Circulation of Solid Organ versus Stem Cell Transplant Recipients

    Directory of Open Access Journals (Sweden)

    A. E. Greijer

    2012-01-01

    Full Text Available Epstein-Barr virus (EBV driven post-transplant lymphoproliferative disease (PTLD is a heterogeneous and potentially life-threatening condition. Early identification of aberrant EBV activity may prevent progression to B-cell lymphoma. We measured EBV DNA load and RNA profiles in plasma and cellular blood compartments of stem cell transplant (SCT; n=5, solid organ transplant recipients (SOT; n=15, and SOT having chronic elevated EBV-DNA load (n=12. In SCT, EBV DNA was heterogeneously distributed, either in plasma or leukocytes or both. In SOT, EBV DNA load was always cell associated, predominantly in B cells, but occasionally in T cells (CD4 and CD8 or monocytes. All SCT with cell-associated EBV DNA showed BARTs and EBNA1 expression, while LMP1 and LMP2 mRNA was found in 1 and 3 cases, respectively. In SOT, expression of BARTs was detected in all leukocyte samples. LMP2 and EBNA1 mRNA was found in 5/15 and 2/15, respectively, but LMP1 mRNA in only 1, coinciding with severe PTLD and high EBV DNA. Conclusion: EBV DNA is differently distributed between white cells and plasma in SOT versus SCT. EBV RNA profiling in blood is feasible and may have added value for understanding pathogenic virus activity in patients with elevated EBV-DNA.

  10. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2010-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  11. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2008-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  12. Conductivity probes for two-phase flow pattern determination during emergency core cooling (ECC) injection experiments at the COCO facility (PHDR)

    Energy Technology Data Exchange (ETDEWEB)

    Prasser, H.M. (Research Centre Rossendorf, Dresden (Germany)); Kueppers, L. (Nuclear Research Centre Karlsruhe (Germany)); May, R. (Fraunhofer Inst. for Nondestructive Testing, Dept. Acoustical Methods for Nondestructive Testing, Evaluation and Quality Assurance, Dresden (Germany))

    1992-07-01

    The paper describes the use of needle-shaped conductivity probes for two-phase flow pattern determination during simulated ECC. The first results appear promising and the use of such probes as additional instrumentation can be envisaged in the future on power reactors, e.g. for the control of water level, once some improvements have been achieved, in particular regarding the stability of the probe. (orig.)

  13. Fabrication of core-shell micro/nanoparticles for programmable dual drug release by emulsion electrospraying

    Energy Technology Data Exchange (ETDEWEB)

    Wang Yazhou, E-mail: yazhou_wang@cqu.edu.cn; Zhang Yiqiong; Wang Bochu, E-mail: wangbc2000@126.com; Cao Yang [Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering (China); Yu Qingsong [University of Missouri, Department of Mechanical and Aerospace Engineering (United States); Yin Tieying [Chongqing University, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering (China)

    2013-06-15

    The study aimed at constructing a novel drug delivery system for programmable multiple drug release controlled with core-shell structure. The core-shell structure consisted of chitosan nanoparticles as core and polyvinylpyrrolidone micro/nanocoating as shell to form core-shell micro/nanoparticles, which was fabricated by ionic gelation and emulsion electrospray methods. As model drug agents, Naproxen and rhodamine B were encapsulated in the core and shell regions, respectively. The core-shell micro/nanoparticles thus fabricated were characterized and confirmed by scanning electron microscope, transmission electron microscope, and fluorescence optical microscope. The core-shell micro/nanoparticles showed good release controllability through drug release experiment in vitro. It was noted that a programmable release pattern for dual drug agents was also achieved by adjusting their loading regions in the core-shell structures. The results indicate that emulsion electrospraying technology is a promising approach in fabrication of core-shell micro/nanoparticles for programmable dual drug release. Such a novel multi-drug delivery system has a potential application for the clinical treatment of cancer, tuberculosis, and tissue engineering.

  14. Conceptual study of advanced PWR core design

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong

    1997-09-01

    The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs.

  15. Ice Cores

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Records of past temperature, precipitation, atmospheric trace gases, and other aspects of climate and environment derived from ice cores drilled on glaciers and ice...

  16. Core BPEL

    DEFF Research Database (Denmark)

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  17. Core BPEL

    DEFF Research Database (Denmark)

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  18. Core benefits

    National Research Council Canada - National Science Library

    Keith, Brian W

    2010-01-01

    This SPEC Kit explores the core employment benefits of retirement, and life, health, and other insurance -benefits that are typically decided by the parent institution and often have significant governmental regulation...

  19. Environment-based pin-power reconstruction method for homogeneous core calculations

    Energy Technology Data Exchange (ETDEWEB)

    Leroyer, H.; Brosselard, C.; Girardi, E. [EDF R and D/SINETICS, 1 av du General de Gaulle, F92141 Claman Cedex (France)

    2012-07-01

    Core calculation schemes are usually based on a classical two-step approach associated with assembly and core calculations. During the first step, infinite lattice assemblies calculations relying on a fundamental mode approach are used to generate cross-sections libraries for PWRs core calculations. This fundamental mode hypothesis may be questioned when dealing with loading patterns involving several types of assemblies (UOX, MOX), burnable poisons, control rods and burn-up gradients. This paper proposes a calculation method able to take into account the heterogeneous environment of the assemblies when using homogeneous core calculations and an appropriate pin-power reconstruction. This methodology is applied to MOX assemblies, computed within an environment of UOX assemblies. The new environment-based pin-power reconstruction is then used on various clusters of 3x3 assemblies showing burn-up gradients and UOX/MOX interfaces, and compared to reference calculations performed with APOLLO-2. The results show that UOX/MOX interfaces are much better calculated with the environment-based calculation scheme when compared to the usual pin-power reconstruction method. The power peak is always better located and calculated with the environment-based pin-power reconstruction method on every cluster configuration studied. This study shows that taking into account the environment in transport calculations can significantly improve the pin-power reconstruction so far as it is consistent with the core loading pattern. (authors)

  20. What do fault patterns reveal about the latest phase of extension within the Northern Snake Range metamorphic core complex, Nevada, USA?

    Science.gov (United States)

    Ismat, Zeshan; Riley, Paul; Lerback, Jory

    2016-08-01

    The Northern Snake Range is a classic example of a metamorphic core complex, Basin-and-Range province, United States. It is composed of a plastically deformed footwall and a brittlely deformed hanging wall, separated by the Northern Snake Range low-angle detachment (NSRD). Brittle deformation, however, is not confined to the hanging wall. This paper focuses on exposures in Cove Canyon, located on the SE flank of the Northern Snake Range, where penetrative, homogeneous faults are well exposed throughout the hanging wall, footwall and NSRD, and overprint early plastic deformation. These late-stage fault sets assisted Eocene-Miocene extension. Detailed analysis of the faults reveals the following: (1) The shortening direction defined by faults is similar to the shortening direction defined by the stretching lineation in the footwall mylonites, indicating that the extensional kinematic history remained unchanged as the rocks were uplifted into the elastico-frictional regime. (2) After ∼17 Ma, extension may have continued entirely within elastic-frictional regime via cataclastic flow. (3) This latest deformation phase may have been accommodated by a single, continuous event. (3) Faults within NSRD boudins indicate that deformation within the detachment zone was non-coaxial during the latest phase of extension.

  1. Generation of Domestic Hot Water, Space Heating and Driving Pattern Profiles for Integration Analysis of Active Loads in Low Voltage Grids

    DEFF Research Database (Denmark)

    Diaz de Cerio Mendaza, Iker; Pigazo, Alberto; Bak-Jensen, Birgitte

    2013-01-01

    demand and electric vehicle driving profiles, to be used for power grid calculations. The generated thermal profiles relied on a statistical analysis made from real domestic hot water and space heating data from 25 households of a typical Danish residential area. The driving profiles instead were formed......The changes in the Danish energy sector, consequence of political agreements, are expected to have direct impact in the actual power distribution systems. Large number of electric boiler, heat pumps and electric vehicles are planned and will cope large percentage of the future power consumption...... at household level. Despite of the well-known flexible service that this kind of loads can provide, their flexibility is highly dependent of the domestic hot water and space heating demand and the driving habits of each user. This paper presents two methodologies employed to randomly generate thermal power...

  2. A modified lateral-load pattern for pushover analysis of torsion-irregular structures%扭转不规则结构水平侧向力分布模式与pushover分析

    Institute of Scientific and Technical Information of China (English)

    唐玉; 郑七振; 楼梦麟

    2012-01-01

    水平侧向力分布模式的施加问题是合理进行pushover分析的关键环节.对于可以简化为平面模型的结构,传统的水平侧向力分布模式表现出较好的适用性,但对于因扭转不规则而导致必须采用空间模型的结构则并不适用.为此,针对扭转不规则结构的水平侧向力分布模式问题,并基于该类结构的地震响应特征,通过引入水平侧向力调整系数和水平侧向力分配系数,提出了扭转不规则结构改进的水平侧向力分布模式.对一具有典型扭转不规则特性的空间钢框架结构分别进行改进分布模式下的pushover分析和IV类场地典型地震动作用下的弹塑性时程分析,计算结果显示:改进分布模式下的pushover分析体现出扭转效应对结构反应的影响,并在一定程度上反映出更多的结构抗震信息,验证了所格出模式的可行性,说明pushover分析法也同样适用于扭转不规则结构.%The influence of lateral-load pattern on models is a key to pushover analysis. For a structure which can be simplified to a plane model, the traditional lateral-load pattern shows a practical application. But it doesn' t work when it comes to those that must he simulaLed as a space model because of torsion-irregular. Aiming at finding an appropriate lateral-load pattern for pushover analysis of torsion-irregular structures, and based on the seismic response of torsi on-irregular structures, a modified lateral-lode pattern is produced by introducing the lateral-load adjustment coefficient and the lateral-load distribution coefficient. These two coefficients can consider the issue of uneven stiffness distribution and the influence of high order modes respectively. At last, an example using both SAP2000 for pushover analysis and dynamic time-history analysis testifies the feasibility and validity of the proposed model. The result shows that the modified pushover analysis can get more structural seismic information than

  3. Sulfur mass loading of the atmosphere from volcanic eruptions: Calibration of the ice core record on basis of sulfate aerosol deposition in polar regions from the 1982 El Chichon eruption

    Science.gov (United States)

    Sigurdsson, Haraldur; Laj, Paolo

    1990-01-01

    Major volcanic eruptions disperse large quantities of sulfur compound throughout the Earth's atmosphere. The sulfuric acid aerosols resulting from such eruptions are scavenged by snow within the polar regions and appear in polar ice cores as elevated acidity layers. Glacio-chemical studies of ice cores can, thus, provide a record of past volcanism, as well as the means for understanding the fate of volcanic sulfur in the atmosphere. The primary objectives of this project are to study the chemistry and physical properties of volcanic fallout in a Greenland Ice Core in order to evaluate the impact of the volcanic gases on the atmospheric chemistry and the total atmospheric mass of volcanic aerosols emitted by major volcanic eruptions. We propose to compare the ice core record to other atmospheric records performed during the last 10 years to investigate transport and deposition of volcanic materials.

  4. Helminths infection patterns in a lizard (Tropidurus hispidus) population from a semiarid neotropical area: associations between female reproductive allocation and parasite loads.

    Science.gov (United States)

    Galdino, Conrado A B; Ávila, Robson W; Bezerra, Castiele H; Passos, Daniel C; Melo, Gabriela C; Zanchi-Silva, Djan

    2014-12-01

    This study reports helminth infection patterns of the lizard Tropidurus hispidus from an area of semiarid caatinga in northeastern Brazil (Ceará state). The lizard population was parasitized by 8 helminth species, and the species composition of the component community resembles that found for other Neotropical lizards. The prevalence of parasites was higher for males compared with females, whereas no relation was found between intensity of infection of 2 parasites (Parapharyngodon alvarengai and Physaloptera lutzi) and the lizards body size. For reproductive females, parasite infection intensity was negatively correlated to reproductive investment.

  5. Mechanical Behavior of CFRP Lattice Core Sandwich Bolted Corner Joints

    Science.gov (United States)

    Zhu, Xiaolei; Liu, Yang; Wang, Yana; Lu, Xiaofeng; Zhu, Lingxue

    2017-02-01

    The lattice core sandwich structures have drawn more attention for the integration of load capacity and multifunctional applications. However, the connection of carbon fibers reinforced polymer composite (CFRP) lattice core sandwich structure hinders its application. In this paper, a typical connection of two lattice core sandwich panels, named as corner joint or L-joint, was investigated by experiment and finite element method (FEM). The mechanical behavior and failure mode of the corner joints were discussed. The results showed that the main deformation pattern and failure mode of the lattice core sandwich bolted corner joints structure were the deformation of metal connector and indentation of the face sheet in the bolt holes. The metal connectors played an important role in bolted corner joints structure. In order to save the calculation resource, a continuum model of pyramid lattice core was used to replace the exact structure. The computation results were consistent with experiment, and the maximum error was 19%. The FEM demonstrated the deflection process of the bolted corner joints structure visually. So the simplified FEM can be used for further analysis of the bolted corner joints structure in engineering.

  6. Assessing and Reducing Miscellaneous Electric Loads (MELs) in Lodging

    Energy Technology Data Exchange (ETDEWEB)

    Rauch, Emily M.

    2011-09-01

    Miscellaneous electric loads (MELs) are the loads outside of a building's core functions of heating, ventilating, air conditioning, lighting, and water heating. This report reviews methods to reduce MELs in lodging.

  7. Evaluation of morphology, aggregation pattern and size-dependent drug-loading efficiency of gold nanoparticles stabilised with poly (2-vinyl pyridine)

    Science.gov (United States)

    Rahim, Sana; Ali, Syed Abid; Ahmed, Farid; Imran, Muhammad; Shah, Muhammad Raza; Malik, Muhammad Imran

    2017-07-01

    Presence of basic nitrogen throughout the chain of poly(2-vinylpyridine) make them alluring candidate for applications requiring chelation of heavy metals. In this study, we report the use of poly (2-vinylpyridine) (P2VP) homopolymers of varying molar masses for the stabilization of gold nanoparticles for the first time. A study based on AFM, DLS and UV-visible spectroscopy was conducted to establish a correlation of the molar mass of P2VP with the size and distribution of the gold nanoparticles. Systematic and gradual change in the absorbance intensity and shift in SPR band of gold nanoparticles were also observed upon variations in treatment temperature, concentration of polymer, residence time, pH, and electrolyte concentration. The results obtained by UV-visible spectroscopy, AFM and DLS are complementary. The size of the P2VP-stabilised AuNPs was found to be in the range of 20-130 nms. At last, the effect of the size of P2VP-stabilised AuNPs (directly related to the molar mass of P2VP) on the drug-loading efficiency is evaluated. [Figure not available: see fulltext.

  8. 根据效率曲线及负载特点合理配置扶梯主机%Configuration of Escalator Machine Based on Efficiency Curve and Load Pattern

    Institute of Scientific and Technical Information of China (English)

    陈正

    2014-01-01

    叙述了扶梯的负载特点、扶梯主机效率曲线的应用、扶梯主机损耗和效率的影响因素、电机和减速箱的类型及其在扶梯中的应用特点,给扶梯主机的合理配置和节能应用提供了实用性的参考建议。%Describe escalator load pattern characters, escalator machine efficiency curve, escalator machine power loss and efficiency impact factors, analyze motor and gearbox type and respective application purpose for escalator, recommend practical reference comment for escalator machine reasonable configuration and energy-saving application.

  9. LIGHT-WEIGHT LOAD-BEARING STRUCTURE

    DEFF Research Database (Denmark)

    2009-01-01

    The invention relates to a light-weight load-bearing structure (1) with optimized compression zone (2), where along one or more compression zones (2) in the structure (1) to be cast a core (3) of strong concrete is provided, which core (3) is surrounded by concrete of less strength (4) compared...... to the core (3) of strong concrete. The invention also relates to a method of casting of light-weight load-bearing structures (1) with optimized compression zone (2) where one or more channels, grooves, ducts, pipes and/or hoses (5) formed in the load-bearing structure (1) serves as moulds for moulding one...... or more cores (3) of strong concrete in the light-weight load-bearing structure (1)....

  10. Hierarchical ZnO Nanowires-loaded Sb-doped SnO2-ZnO Micrograting Pattern via Direct Imprinting-assisted Hydrothermal Growth and Its Selective Detection of Acetone Molecules.

    Science.gov (United States)

    Choi, Hak-Jong; Choi, Seon-Jin; Choo, Soyoung; Kim, Il-Doo; Lee, Heon

    2016-01-08

    We propose a novel synthetic route by combining imprinting transfer of a Sb-doped SnO2 (ATO)-ZnO composite micrograting pattern (MP), i.e., microstrip lines, on a sensor substrate and subsequent hydrothermal growth of ZnO nanowires (NWs) for producing a hierarchical ZnO NW-loaded ATO-ZnO MP as an improved chemo-resistive sensing layer. Here, ATO-ZnO MP structure with 3-μm line width, 9-μm pitch, and 6-μm height was fabricated by direct transfer of mixed ATO and ZnO nanoparticle (NP)-dispersed resists, which are pre-patterned on a polydimethylsiloxane (PDMS) mold. ZnO NWs with an average diameter of less than 50 nm and a height of 250 nm were quasi-vertically grown on the ATO-ZnO MP, leading to markedly enhanced surface area and heterojunction composites between each ATO NP, ZnO NP, and ZnO NW. A ZnO NW-loaded MP sensor with a relative ratio of 1:9 between ATO and ZnO (1:9 ATO-ZnO), exhibited highly sensitive and selective acetone sensing performance with 2.84-fold higher response (R air/R gas = 12.8) compared to that (R air/R gas = 4.5) of pristine 1:9 ATO-ZnO MP sensor at 5 ppm. Our results demonstrate the processing advantages of direct imprinting-assisted hydrothermal growth for large-scale homogeneous coating of hierarchical oxide layers, particularly for applications in highly sensitive and selective chemical sensors.

  11. Iron load

    Directory of Open Access Journals (Sweden)

    Filippo Cassarà

    2013-03-01

    Full Text Available Recent research addressed the main role of hepcidin in the regulation of iron metabolism. However, while this mechanism could be relevant in causing iron load in Thalassemia Intermedia and Sickle-Cell Anemia, its role in Thalassemia Major (TM is marginal. This is mainly due to the high impact of transfusional requirement into the severe increase of body iron. Moreover, the damage of iron load may be worsened by infections, as HCV hepatitis, or liver and endocrinological damage. One of the most relevant associations was found between splenectomy and increase of risk for mortality due,probably, to more severe iron load. These issues suggest as morbidity and mortality of this group of patients they do not depend only by our ability in controlling heart damage but even in preventing or treating particular infections and complications. This finding is supported by the impairment of survival curves in patients with complications different from heart damage. However, because, during recent years different direct and indirect methods to detect iron overload in patients affected by secondary hemochromatosis have been implemented, our ability to maintain under control iron load is significantly improved. Anyway, the future in iron load management remains to be able to have an iron load map of our body for targeting chelation and other medical treatment according to the single organ damage.

  12. The design of reload cores using optimal control theory

    Energy Technology Data Exchange (ETDEWEB)

    Terney, W.B.; Williamson, E.A.

    1982-11-01

    A formal approach for the optimization of the final design of reload cores has been devised and verified. The method is based on applying the calculus of variations (Pontryagin's principle) to the normal flux and depletion system equations. The resulting set of coupled system, Euler-Lagrange (E-L), and optimality equations are solved iteratively. This is done by assuming a loading pattern for the old fuel, first solving the system equations, and then the E-L equations. The pattern is then modified by using the optimality (or Pontryagin) condition, and the process is repeated until no further improvements can be made. A computer program, OPMUV, implementing these procedures has been written and verified. The code can handle two-dimensional, quarter-core symmetric configurations with up to 241 assemblies and 4 nodes per assembly with modified one-group theory. It also has the capability of optimizing over the entire depletion cycle as well as just at the beginning of cycle (BOC). The results show that the procedure does work. In all cases tried, the method led to a reduction in nodal peaks of 1 to 3% over the final designer-obtained loading pattern within a couple of iterations. These savings carry over to comparable reductions in pin peaks when the optimized patterns are used in four-group, fine-mesh calculations. Since the changes on each iteration are limited to ensure convergence, the method is thus well suited for the final fine tuning of the normally obtained patterns to gain an extra few percent in power flattening.

  13. Resistance to cyclic loading of teeth restored with posts

    DEFF Research Database (Denmark)

    Sahafi, A; Peutzfeldt, A; Ravnholt, G

    2005-01-01

    This in vitro study evaluated the effect of presence of post, presence of core, and of shape, type, and surface treatment of posts on resistance to cyclic loading of crowned human teeth. For all teeth, crowns designed without ferrule were cast in sterling silver and luted with resin cement (Panavia...... F). Each tooth underwent cyclic loading of 600 N at two loads per second until failure. Teeth that had only been crowned showed significantly higher resistance to cyclic loading than teeth with cores or with post and cores. No significant differences were found between teeth restored with cores only...... or with post and cores, irrespective of surface-treatment of the posts. Teeth restored with parallel-sided cast post (ParaPost XP) and cores showed significantly higher resistance to cyclic loading than teeth with either tapered cast posts or untreated prefabricated posts of titanium alloy (ParaPost XH...

  14. COSIS: COre State Indication System

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Lee, K. B.; Koo, B. S.; Lee, W. K.; Lee, C. C; Zee, S. Q

    2006-02-15

    full power to 50% condition at 200 second, and from 50% at 1000 second to full power at 1200 second. In the core simulation test, COSIS works well showing the maximum core power error of 0.5% near the 1200 second. The POWER3D test is performed for one normal case, two fuel mis-loaded cases. The power sharing factors and the power coupling coefficients are generated from the power distribution of the normal case, and the detector signals from the power distribution of each case. In the normal case, COSIS produced the same power distribution of the normal case, which means the soundness of the POWER3D module. In the two mis-loaded cases, COSIS produced worthful results.

  15. Selective randomized load balancing and mesh networks with changing demands

    Science.gov (United States)

    Shepherd, F. B.; Winzer, P. J.

    2006-05-01

    We consider the problem of building cost-effective networks that are robust to dynamic changes in demand patterns. We compare several architectures using demand-oblivious routing strategies. Traditional approaches include single-hop architectures based on a (static or dynamic) circuit-switched core infrastructure and multihop (packet-switched) architectures based on point-to-point circuits in the core. To address demand uncertainty, we seek minimum cost networks that can carry the class of hose demand matrices. Apart from shortest-path routing, Valiant's randomized load balancing (RLB), and virtual private network (VPN) tree routing, we propose a third, highly attractive approach: selective randomized load balancing (SRLB). This is a blend of dual-hop hub routing and randomized load balancing that combines the advantages of both architectures in terms of network cost, delay, and delay jitter. In particular, we give empirical analyses for the cost (in terms of transport and switching equipment) for the discussed architectures, based on three representative carrier networks. Of these three networks, SRLB maintains the resilience properties of RLB while achieving significant cost reduction over all other architectures, including RLB and multihop Internet protocol/multiprotocol label switching (IP/MPLS) networks using VPN-tree routing.

  16. Core Java

    CERN Document Server

    Horstmann, Cay S

    2013-01-01

    Fully updated to reflect Java SE 7 language changes, Core Java™, Volume I—Fundamentals, Ninth Edition, is the definitive guide to the Java platform. Designed for serious programmers, this reliable, unbiased, no-nonsense tutorial illuminates key Java language and library features with thoroughly tested code examples. As in previous editions, all code is easy to understand, reflects modern best practices, and is specifically designed to help jumpstart your projects. Volume I quickly brings you up-to-speed on Java SE 7 core language enhancements, including the diamond operator, improved resource handling, and catching of multiple exceptions. All of the code examples have been updated to reflect these enhancements, and complete descriptions of new SE 7 features are integrated with insightful explanations of fundamental Java concepts.

  17. Beam loading

    CERN Document Server

    Gamp, Alexander

    2013-01-01

    We begin by giving a description of the radio-frequency generator-cavity-beam coupled system in terms of basic quantities. Taking beam loading and cavity detuning into account, expressions for the cavity impedance as seen by the generator and as seen by the beam are derived. Subsequently methods of beam-loading compensation by cavity detuning, radio-frequency feedback and feedforward are described. Examples of digital radio-frequency phase and amplitude control for the special case of superconducting cavities are also given. Finally, a dedicated phase loop for damping synchrotron oscillations is discussed.

  18. Buckling and dynamic analysis of drill strings for core sampling

    Energy Technology Data Exchange (ETDEWEB)

    Ziada, H.H., Westinghouse Hanford

    1996-05-15

    This supporting document presents buckling and dynamic stability analyses of the drill strings used for core sampling. The results of the drill string analyses provide limiting operating axial loads and rotational speeds to prevent drill string failure, instability and drill bit overheating during core sampling. The recommended loads and speeds provide controls necessary for Tank Waste Remediation System (TWRS) programmatic field operations.

  19. Carbohydrate Loading.

    Science.gov (United States)

    Csernus, Marilyn

    Carbohydrate loading is a frequently used technique to improve performance by altering an athlete's diet. The objective is to increase glycogen stored in muscles for use in prolonged strenuous exercise. For two to three days, the athlete consumes a diet that is low in carbohydrates and high in fat and protein while continuing to exercise and…

  20. Load sensor

    NARCIS (Netherlands)

    Van den Ende, D.; Almeida, P.M.R.; Dingemans, T.J.; Van der Zwaag, S.

    2007-01-01

    The invention relates to a load sensor comprising a polymer matrix and a piezo-ceramic material such as PZT, em not bedded in the polymer matrix, which together form a compos not ite, wherein the polymer matrix is a liquid crystalline resin, and wherein the piezo-ceramic material is a PZT powder for

  1. Carbohydrate Loading.

    Science.gov (United States)

    Csernus, Marilyn

    Carbohydrate loading is a frequently used technique to improve performance by altering an athlete's diet. The objective is to increase glycogen stored in muscles for use in prolonged strenuous exercise. For two to three days, the athlete consumes a diet that is low in carbohydrates and high in fat and protein while continuing to exercise and…

  2. Controlled Release of Ciprofloxacin from Core-Shell Nanofibers with Monolithic or Blended Core.

    Science.gov (United States)

    Zupančič, Špela; Sinha-Ray, Sumit; Sinha-Ray, Suman; Kristl, Julijana; Yarin, Alexander L

    2016-04-04

    Sustained controlled drug release is one of the prominent contributions for more successful treatment outcomes in the case of several diseases. However, the incorporation of hydrophilic drugs into nanofibers, a promising novel delivery system, and achieving a long-term sustained release still pose a challenging task. In this work we demonstrated a robust method of avoiding burst release of drugs and achieving a sustained drug release from 2 to 4 weeks using core-shell nanofibers with poly(methyl methacrylate) (PMMA) shell and monolithic poly(vinyl alcohol) (PVA) core or a novel type of core-shell nanofibers with blended (PVA and PMMA) core loaded with ciprofloxacin hydrochloride (CIP). It is also shown that, for core-shell nanofibers with monolithic core, drug release can be manipulated by varying flow rate of the core PVA solution, whereas for core-shell nanofibers with blended core, drug release can be manipulated by varying the ratios between PMMA and PVA in the core. During coaxial electrospinning, when the solvent from the core evaporates in concert with the solvent from the shell, the interconnected pores spanning the core and the shell are formed. The release process is found to be desorption-limited and agrees with the two-stage desorption model. Ciprofloxacin-loaded nanofiber mats developed in the present work could be potentially used as local drug delivery systems for treatment of several medical conditions, including periodontal disease and skin, bone, and joint infections.

  3. Rambling and trembling in response to body loading.

    Science.gov (United States)

    Tahayor, Behdad; Riley, Zachary A; Mahmoudian, Armaghan; Koceja, David M; Hong, Siang Lee

    2012-04-01

    Various studies have suggested that postural sway is controlled by at least two subsystems. Rambling-Trembling analysis is a widely accepted methodology to dissociate the signals generated by these two hypothetical subsystems. The core assumption of this method is based on the equilibrium point hypothesis which suggests that the central nervous system preserves upright standing by transiently shifting the center of pressure (COP) from one equilibrium point to another. The trajectory generated by this shifting is referred to as rambling and its difference from the original COP signal is referred to as trembling. In this study we showed that these two components of COP are differentially affected when standing with external loads. Using Detrended Fluctuation analysis, we compared the pattern of these two signals in different configurations of body loading. Our findings suggest that by applying an external load, the dynamics of the trembling component is altered independently of the area of postural sway and also independently of the rambling component. The dynamics of rambling changed only during the backloading condition in which the postural sway area also substantially increased. It can be suggested that during loaded standing, the trembling mechanism (which is suggested to be activated by peripheral mechanisms and reflexes) is altered without affecting the central influence on the shifts of the equilibrium point.

  4. Dual-responsive mPEG-PLGA-PGlu hybrid-core nanoparticles with a high drug loading to reverse the multidrug resistance of breast cancer: an in vitro and in vivo evaluation.

    Science.gov (United States)

    Xu, Helin; Yang, Dan; Cai, Cuifang; Gou, Jingxin; Zhang, Yu; Wang, Lihui; Zhong, Haijun; Tang, Xing

    2015-04-01

    In this study, monomethoxy (polyethylene glycol)-b-P (d,l-lactic-co-glycolic acid)-b-P (l-glutamic acid) (mPEG-PLGA-PGlu) nanoparticles with the ability to rapidly respond to the endolysosomal pH and hydrolase were prepared and the pH-sensitivity was tuned by adjusting the length of the PGlu segment. The mPEG5k-PLGA20k-PGlu (60) nanoparticles were specifically responsive to an endosomal pH of 5.0-6.0 due to the configuration transition of the PGlu segment and rapidly initiated chemical degradation after incubation with proteinase k for 10 min. Doxorubicin hydrochloride (DOX), used as a model drug, was easily encapsulated into nanoparticles and the DOX-loaded nanoparticles (DOX-NPs) exhibited a pH-dependent and enzyme-sensitive release profile in vitro. The dual sensitivity enabled the rapid escape of DOX-loaded nanoparticles from the endolysosomal system to target cellular nuclei, which resulted in increased cell toxicity against MCF/ADR resistant breast cancer cells and a higher cellular uptake than free DOX. In Vivo Imaging studies indicated that the nanoparticles could continuously accumulate in the tumor tissues through EPR effects and Ex vivo Imaging biodistribution studies indicated that DOX-NPs increased drug penetration into tumors compared with normal tissues. The in vivo antitumor activity demonstrated that DOX-loaded NPs had less body loss and a significant regression of tumor growth, indicating the increased anti-tumor efficacy and lower systemic toxicity. Therefore, this dual sensitive nanoparticle system may be a potential nanocarrier to overcome the multidrug resistance exhibited by breast cancer.

  5. Parallel Frequent Pattern Discovery: Challenges and Methodology

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Parallel frequent pattern discovery algorithms exploit parallel and distributed computing resources to relieve the sequential bottlenecks of current frequent pattern mining (FPM) algorithms. Thus, parallel FPM algorithms achieve better scalability and performance, so they are attracting much attention in the data mining research community. This paper presents a comprehensive survey of the state-of-the-art parallel and distributed frequent pattern mining algorithms with more emphasis on pattern discovery from complex data (e.g., sequences and graphs) on various platforms. A review of typical parallel FPM algorithms uncovers the major challenges, methodologies, and research problems in the field of parallel frequent pattern discovery,such as work-load balancing, finding good data layouts, and data decomposition. This survey also indicates a dramatic shift of the research interest in the field from the simple parallel frequent itemset mining on traditional parallel and distributed platforms to parallel pattern mining of more complex data on emerging architectures, such as multi-core systems and the increasingly mature grid infrastructure.

  6. Regional Economic Analysis for Shijiazhuang Based on "One-Core-Four-Star" Development Pattern%石家庄“一核四星”发展模式的区域经济分析

    Institute of Scientific and Technical Information of China (English)

    孟祥林

    2014-01-01

    Shijiazhuang is a city "pulled by train",and urban development speed is very high. In the process of ur-ban development,the factors of"hub" and"administrative center" have played important role. As a provincial cap-ital city,Shijiazhuang also faces many restrictive factors for development:the asymmetry between administrative cen-ter and regional center;the asymmetry between development speed and the connotation of the city;the asymmetry between culture and city image. Because of the reasons above,the process of urban development for Shijiazhuang must based on"Big Shijiazhuang" perspective."Big Shijiazhuang" urban system can be constructed as"One-Core-Four-Star" pattern,four sub-urban centers circling Shijiazhuang are Zhengding,Luancheng,Gaocheng,Luquan ( in-cluding Jingxing) ,four levels urban system at the same developed:core city→secondary city→subgroup→small group. In turn,metropolis and the hinterland can be effectively integrated,Shijiazhuang urban system as the core of south Beijing area is formed,and Shijiazhuang also play more and more important role within the large scope of Bei-jing,Tianjin,Hebei,Shandong,Shanxi.%石家庄是“火车拉来的城市”,城市发展速度很快,在城市发展进程中,“交通枢纽”和“行政中心”这两个因素起了重要作用。石家庄作为省会城市,在发展中也面临诸多限制性因素:行政中心与区域中心不对称,发展速度与城市内涵不对称,文化底蕴与大都市形象不对称。这要求城市发展进程中从“大石家庄”视角出发,在京津冀大背景下规划石家庄城市体系,以正定、栾城、藁城、鹿泉(包括井陉),构建“一核四星”的城市发展格局,才能够形成“核心城市→次级城市→城市子群→小城镇团”的四级结构,进而大都市与腹地得到有效整合,以石家庄为核心的京南都市体系得以形成,石家庄的城市影响力得到强化,在京津冀鲁晋等大范围内发挥重要作用。

  7. Central core disease

    Directory of Open Access Journals (Sweden)

    Jungbluth Heinz

    2007-05-01

    Full Text Available Abstract Central core disease (CCD is an inherited neuromuscular disorder characterised by central cores on muscle biopsy and clinical features of a congenital myopathy. Prevalence is unknown but the condition is probably more common than other congenital myopathies. CCD typically presents in infancy with hypotonia and motor developmental delay and is characterized by predominantly proximal weakness pronounced in the hip girdle; orthopaedic complications are common and malignant hyperthermia susceptibility (MHS is a frequent complication. CCD and MHS are allelic conditions both due to (predominantly dominant mutations in the skeletal muscle ryanodine receptor (RYR1 gene, encoding the principal skeletal muscle sarcoplasmic reticulum calcium release channel (RyR1. Altered excitability and/or changes in calcium homeostasis within muscle cells due to mutation-induced conformational changes of the RyR protein are considered the main pathogenetic mechanism(s. The diagnosis of CCD is based on the presence of suggestive clinical features and central cores on muscle biopsy; muscle MRI may show a characteristic pattern of selective muscle involvement and aid the diagnosis in cases with equivocal histopathological findings. Mutational analysis of the RYR1 gene may provide genetic confirmation of the diagnosis. Management is mainly supportive and has to anticipate susceptibility to potentially life-threatening reactions to general anaesthesia. Further evaluation of the underlying molecular mechanisms may provide the basis for future rational pharmacological treatment. In the majority of patients, weakness is static or only slowly progressive, with a favourable long-term outcome.

  8. Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.

    Science.gov (United States)

    Boscia, Francesca; Gala, Rosaria; Pignataro, Giuseppe; de Bartolomeis, Andrea; Cicale, Maria; Ambesi-Impiombato, Alberto; Di Renzo, Gianfranco; Annunziato, Lucio

    2006-04-01

    Dysregulation of sodium [Na+]i and calcium [Ca2+]i homeostasis plays a pivotal role in the pathophysiology of cerebral ischemia. Three gene products of the sodium-calcium exchanger family NCX1, NCX2, and NCX3 couple, in a bidirectional way, the movement of these ions across the cell membrane during cerebral ischemia. Each isoform displays a selective distribution in the rat brain. To determine whether NCX gene expression can be regulated after cerebral ischemia, we used NCX isoform-specific antisense radiolabeled probes to analyze, by radioactive in situ hybridization histochemistry, the pattern of NCX1, NCX2, and NCX3 transcripts in the ischemic core, periinfarct area, as well as in nonischemic brain regions, after 6 and 24 h of permanent middle cerebral artery occlusion (pMCAO) in rats. We found that in the focal region, comprising divisions of the prefrontal, somatosensory, and insular cortices, all three NCX transcripts were downregulated. In the periinfarct area, comprising part of the motor cortex and the lateral compartments of the caudate-putamen, NCX2 messenger ribonucleic acid (mRNA) was downregulated, whereas NCX3 mRNA was significantly upregulated. In remote nonischemic brain regions such as the prelimbic and infralimbic cortices, and tenia tecta, both NCX1 and NCX3 transcripts were upregulated, whereas in the medial caudate-putamen only NCX3 transcripts increased. In all these intact regions, NCX2 signal strongly decreased. These results indicate that NCX gene expression is regulated after pMCAO in a differential manner, depending on the exchanger isoform and region involved in the insult. These data may provide a better understanding of each NCX subtype's pathophysiologic role and may allow researchers to design appropriate pharmacological strategies to treat brain ischemia.

  9. Dynamic Response of RPC-Filled Steel Tubular Columns with High Load Carrying Capacity Under Axial Impact Loading

    Institute of Scientific and Technical Information of China (English)

    TIAN Zhimin; WU Ping'an; JIA Jianwei

    2008-01-01

    Experimental investigation into impact-resistant behavior of reactive powder concrete (RPC)-filled steel tubular columns was conducted, and dynamic response of the columns under axial impact loading was studied by means of numerical simulation method.Increase coefficient of load carrying capacity and ratio of load carrying capacity between steel tube and RPC core of columns were obtained.

  10. Advantages of iron core in a tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Bettis, E.S.; Ballou, J.K.; Becraft, W.R.; Peng, Y.K.M.; Watts, H.L.

    1977-01-01

    A quantitative comparison of the iron core vs air core concepts was carried out on a preliminary basis by using a representative tokamak reactor design with the following self-consistent reference parameters. In the area of plasma engineering, poloidal field and MHD equilibrium considerations with an unsaturated iron core is discussed. The question of proper poloidal field coils to maintain D-shaped plasmas of relatively high anti ..beta.. (7%) with a saturated iron core is also discussed. Estimates of the required iron core size, volt seconds, magnetic flux and its influence on force loading on the superconducting toroidal field coils are shown. Conceptual designs of the mechanical structure of an iron core device are presented. Favorable impacts on the OH power supply cost and complexity are indicated.

  11. Study on Effect of MOX Fuel Assembly Loaded in Current M310 Reactor Core on Nuclear Design%MOX 燃料组件装入现役 M310堆芯对堆芯核设计的影响研究

    Institute of Scientific and Technical Information of China (English)

    刘晓黎; 宫宇

    2015-01-01

    国际上的 MOX 燃料技术目前已较为成熟,且已有在压水堆中运行的工程经验。本文对 MOX 燃料组件的中子学性能进行了分析,对其在我国现役 M310堆芯应用的可行性进行了研究,得到了 M310堆芯由全部使用 UO2燃料组件向使用30%的 MOX 燃料组件过渡的堆芯燃料管理方案,并对使用MOX 燃料组件的堆芯的部分中子学参数进行了初步分析。结果表明:使用30%的 MOX 燃料组件的堆芯可达到与全 UO2堆芯相当的循环长度;堆芯反应性控制能力可满足要求;慢化剂温度系数、Doppler温度系数、Doppler 功率系数、氙和钐的动态特性均趋向使堆芯运行更加安全和稳定。本文的研究结果可为 MOX 燃料在 M310堆芯中应用的进一步研究提供参考。%The MOX fuel technology has been developed and applied in PWR all over the world .In this paper ,the neutronic performance of the MOX fuel assembly was studied , and fuel management scheme of M310 reactor core from all UO2 fuel assemblies to 30%MOX fuel assemblies was given .The results show that the core loaded 30% MOX fuel assemblies can reach the same lifetime as the all UO2 core ,the ability of the control system can meet the requirement of reactivity control ,and the Doppler temperature and power coefficients ,moderator temperature coefficient and the evolutions of Xe and Sm all benefit for the core operation to be more stable .The results of this study prove that the MOX fuel assembly can be used in the M310 reactor core .

  12. Emergence of core-peripheries in networks

    CERN Document Server

    Verma, T; Araújo, N A M; Nagler, J; Herrmann, H J

    2016-01-01

    A number of important transport networks, such as the airline and trade networks of the world, exhibit a characteristic core-periphery structure, wherein a few nodes are highly interconnected and the rest of the network frays into a tree. Mechanisms underlying the emergence of core-peripheries, however, remain elusive. Here, we demonstrate that a simple pruning process based on removal of underutilized links and redistribution of loads can lead to the emergence of core-peripheries. Links are assumed beneficial if they either carry a sufficiently large load or are essential for global connectivity. This incentivized redistribution process is controlled by a single parameter which balances connectivity and profit. The obtained networks exhibit a highly resilient and connected core with a frayed periphery. The balanced network shows a higher resilience than the World Airline Network or the World Trade Network, revealing a pathway towards robust structural features through pruning.

  13. Influence of masticatory fatigue on the fracture resistance of the pulpless teeth restored with quartz-fiber post-core and crown.

    Science.gov (United States)

    Nie, Er-Min; Chen, Xia-Yun; Zhang, Chun-Yuan; Qi, Li-Li; Huang, Ying-He

    2012-12-01

    To investigate whether masticatory fatigue affects the fracture resistance and pattern of lower premolars restored with quartz-fiber post-core and full crown, 44 single rooted lower premolars recently extracted from orthodontic patients were divided into two groups of 22 each. The crowns of all teeth were removed and endodontically treated and then restored with quartz-fiber post-core and full crown. Twenty-two teeth in one group were selected randomly and circularly loaded at 45° to the long axis of the teeth of 127.4 N at a 6 Hz frequency, and the other group was not delivered to cyclic loading and considered as control. Subsequently, all teeth in two groups were continually loaded to fail at 45° to the long axis of the teeth at a crosshead speed of 1 mm⋅min(-1). The mean destructive force values were (733.88±254.99) and (869.14±280.26) N for the experimental and the control group, respectively, and no statistically significant differences were found between two groups (P>0.05). Bevel fracture and horizontal fracture in the neck of root were the major fracture mode of the specimens. Under the circumstances of this study, it seems that cyclic loading does not affect the fracture strength and pattern of the quartz-fiber post-core-crown complex.

  14. Load testing circuit

    DEFF Research Database (Denmark)

    2009-01-01

    A load testing circuit a circuit tests the load impedance of a load connected to an amplifier. The load impedance includes a first terminal and a second terminal, the load testing circuit comprising a signal generator providing a test signal of a defined bandwidth to the first terminal of the load...

  15. Earth's core and the geodynamo

    Science.gov (United States)

    Buffett

    2000-06-16

    Earth's magnetic field is generated by fluid motion in the liquid iron core. Details of how this occurs are now emerging from numerical simulations that achieve a self-sustaining magnetic field. Early results predict a dominant dipole field outside the core, and some models even reproduce magnetic reversals. The simulations also show how different patterns of flow can produce similar external fields. Efforts to distinguish between the various possibilities appeal to observations of the time-dependent behavior of the field. Important constraints will come from geological records of the magnetic field in the past.

  16. Dual-core antiresonant hollow core fibers.

    Science.gov (United States)

    Liu, Xuesong; Fan, Zhongwei; Shi, Zhaohui; Ma, Yunfeng; Yu, Jin; Zhang, Jing

    2016-07-25

    In this work, dual-core antiresonant hollow core fibers (AR-HCFs) are numerically demonstrated, based on our knowledge, for the first time. Two fiber structures are proposed. One is a composite of two single-core nested nodeless AR-HCFs, exhibiting low confinement loss and a circular mode profile in each core. The other has a relatively simple structure, with a whole elliptical outer jacket, presenting a uniform and wide transmission band. The modal couplings of the dual-core AR-HCFs rely on a unique mechanism that transfers power through the air. The core separation and the gap between the two cores influence the modal coupling strength. With proper designs, both of the dual-core fibers can have low phase birefringence and short modal coupling lengths of several centimeters.

  17. Enhanced immunoassay for porcine circovirus type 2 antibody using enzyme-loaded and quantum dots-embedded shell–core silica nanospheres based on enzyme-linked immunosorbent assay

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Long; Li, Xuepu; Shao, Kang; Ye, Shiyi; Liu, Chen; Zhang, Chenjun; Han, Heyou, E-mail: hyhan@mail.hzau.edu.cn

    2015-08-05

    Boosting the detection sensitivity of enzyme-linked immunosorbent assay (ELISA) is significant to the early clinical diagnosis of various diseases. Here, we developed a versatile immunosensor using silica nanospheres as carriers for sensitive detection of porcine circovirus type 2 (PCV2) antibody. With HRP enzyme covalently immobilized on the silica nanospheres and CdSe nanocrystals embedded inside, these signal probes were successfully utilized in the sensitive detection of PCV2 antibody by ELISA, fluorometry and square-wave voltammetry (SWV). To further demonstrate the performance of the immunosensor, Human IgG (HIgG) was used as a model analyte. Since more HRP and CdSe QDs were loaded, 5-, 200- and 400-fold enhancements in amplified ELISA, fluorometry and voltammetry responses for HIgG could be achieved compared to conventional ELISA. The respective detection limits of theses methods for HIgG were 3.9, 0.1 and 0.05 ng mL{sup −1} with a RSD below 5% for amplified ELISA, fluorescence and SWV measurements. Additionally, a 100-fold improvement was obtained in the detection sensitivity for PCV2 antibody immunoassay. The versatile immunosensor exhibits good sensitivity, stability and reproducibility, suggesting its potential applications in clinical diagnostics. - Highlights: • A versatile ELISA-based immunoassay for PCV2 antibody was developed. • Enzyme and CdSe QDs modified SiO{sub 2} particles were used to improve sensitivity. • The simultaneous three ELISA-based techniques enhanced the detection reliability. • The biosensors strategy could provide a new avenue to ELISA-based sensors.

  18. Dynamics of core accretion

    Science.gov (United States)

    Nelson, Andrew F.; Ruffert, Maximilian

    2013-02-01

    We perform three-dimensional hydrodynamic simulations of gas flowing around a planetary core of mass Mpl = 10M⊕ embedded in a near Keplerian background flow, using a modified shearing box approximation. We assume an ideal gas behaviour following an equation of state with a fixed ratio of the specific heats, γ = 1.42, consistent with the conditions of a moderate-temperature background disc with solar composition. No radiative heating or cooling is included in the models. We employ a nested grid hydrodynamic code implementing the `Piecewise Parabolic Method' with as many as six fixed nested grids, providing spatial resolution on the finest grid comparable to the present-day diameters of Neptune and Uranus. We find that a strongly dynamically active flow develops such that no static envelope can form. The activity is not sensitive to plausible variations in the rotation curve of the underlying disc. It is sensitive to the thermodynamic treatment of the gas, as modelled by prescribed equations of state (either `locally isothermal' or `locally isentropic') and the temperature of the background disc material. The activity is also sensitive to the shape and depth of the core's gravitational potential, through its mass and gravitational softening coefficient. Each of these factors influences the magnitude and character of hydrodynamic feedback of the small-scale flow on the background, and we conclude that accurate modelling of such feedback is critical to a complete understanding of the core accretion process. The varying flow pattern gives rise to large, irregular eruptions of matter from the region around the core which return matter to the background flow: mass in the envelope at one time may not be found in the envelope at any later time. No net mass accretion into the envelope is observed over the course of the simulation and none is expected, due to our neglect of cooling. Except in cases of very rapid cooling however, as defined by locally isothermal or

  19. Discussion on the Progressive Teaching Pattern with the Core of Skills Experience%以技能体验为核心的递进式教学模式探讨

    Institute of Scientific and Technical Information of China (English)

    王洪彬

    2015-01-01

    Training on college students’ skill is one of the important issues in the teaching reform of higher education in recent years,which teaching pattern we are supposed to choice is the core of the research. Combined with the skills of the formation of the common law, progressive teaching pattern can be divided into three stages,through the teaching task of every stage,and then they are divided into seven parts, they are:knowledge learning, concept conclusion, fragments of imitation, integration and the practice,multiple stereo type training,pre job and on-the-job training. The first phase of the main task is to make the students to have a clear image or recognition in their mind or operation;the second stage is to highlight the skills of each fragment,and then combined with the story, imitation and instruments and other methods to complete the integration of skills. The third stage is to achieve the comprehensive ability of the training,to achieve the pur-suit of practical skills. Studies suggest that this teaching model can provide a skill operation of the simulation space or skills training experience, which can make the students integrate into the workplace faster and better.%大学生技能培养是近年来高校教学改革探讨的重要议题之一,采用何种教学模式实现培养目标则是研究核心。本文结合技能形成的普遍规律,将递进式教学模式分为三个阶段,通过每一个阶段的教学任务,再划分成知识学习、概念建立、片段模仿、整合练习、多元立体式训练、岗前和顶岗实训七个模块。第一阶段主要任务是使学生在头脑中或操作上,对技能有一个清晰的映像或认知;第二阶段要凸显每个片段技能特点,然后再结合讲述、模仿和器械等方法完成技能的整合。第三阶段是通过特色的教学设计等,追求技能的实用化,实现综合能力的培养。研究认为,这种教学模式可以提供一个技能操作

  20. Fuel management strategy for the new equilibrium silicide core design of RSG GAS (MPR-30)

    Energy Technology Data Exchange (ETDEWEB)

    Hong Liem Peng; Arbie, Bakri; Sembiring, T.M. [National Atomic Energy Agency (Batan), Center for Multipurpose Reactor, Tangerang (Indonesia)

    1997-07-01

    The design procedure and fuel management strategy were proposed for converting the oxide core of RSG GAS (MPR-30) to the new equilibrium silicide core using higher uranium loading. The obtained silicide core gave significant extension of the core cycle length and thus increasing the reactor availability and utilisation. (author)

  1. Fuel management strategy for the new equilibrium silicide core design of RSG GAS (MPR-30)

    Energy Technology Data Exchange (ETDEWEB)

    Hong Liem Peng; Arbie, Bakri; Sembiring, T.M. [National Atomic Energy Agency (Batan), Center for Multipurpose Reactor, Tangerang (Indonesia)

    1997-07-01

    The design procedure and fuel management strategy were proposed for converting the oxide core of RSG GAS (MPR-30) to the new equilibrium silicide core using higher uranium loading. The obtained silicide core gave significant extension of the core cycle length and thus increasing the reactor availability and utilisation. (author) 4 figs., 1 tab., refs.

  2. Loads and loads and loads: The influence of prospective load, retrospective load, and ongoing task load in prospective memory

    Directory of Open Access Journals (Sweden)

    Beat eMeier

    2015-06-01

    Full Text Available In prospective memory tasks different kinds of load can occur. Adding a prospective memory task can impose a load on ongoing task performance. Adding ongoing task load can affect prospective memory performance. The existence of multiple target events increases prospective load and adding complexity to the to-be-remembered action increases retrospective load. In two experiments, we systematically examined the effects of these different types of load on prospective memory performance. Results showed an effect of prospective load on costs in the ongoing task for categorical targets (Experiment 2, but not for specific targets (Experiment 1. Retrospective load and ongoing task load both affected remembering the retrospective component of the prospective memory task. We suggest that prospective load can enhance costs in the ongoing task due to additional monitoring requirements. Retrospective load and ongoing task load seem to impact the division of resources between the ongoing task and retrieval of the retrospective component, which may affect disengagement from the ongoing task. In general, the results demonstrate that the different types of load affect prospective memory differentially.

  3. Animal MRI Core

    Data.gov (United States)

    Federal Laboratory Consortium — The Animal Magnetic Resonance Imaging (MRI) Core develops and optimizes MRI methods for cardiovascular imaging of mice and rats. The Core provides imaging expertise,...

  4. 采用钢结构加层的混凝土框架结构的侧向力分布比较%Load Pattern Compared of RC Frame Structures after Steel Adding Storey in Pushover Analysis

    Institute of Scientific and Technical Information of China (English)

    林敏

    2012-01-01

    Pushover analysis is a simplified method for structure seismic evaluation,which is extensively used gradually,and is recommended by the new national code of seismic design of buildings.The load pattern selection is one of the critical issues in pushover analysis,especially to the RC frame after steel adding storey,for the distribution of lateral force Pushover analysis result is more significant impact.Based on the three groups of six types of framework,different lateral force distribution was selected for pushover analysis,and the nonlinear time-history analysis results were compared.The results show that,for RC frame structure after steel adding storey directly,the results obtained of different lateral force distribution of pushover are different,and the time-history analysis results of deviation bigger also.%Pushover分析方法是逐渐得到广泛应用的一种评估结构抗震性能的简化方法,已被引入我国新的建筑结构抗震设计规范。侧向力分布的选取是结构Pushover分析中的一个关键问题,尤其是对于混凝土框架直接加层钢框架结构,由于上下层间刚度比差异较大,侧向力分布对其Pushover分析的结果影响更为显著。文章通过对3组共6榀加层框架,选取不同的侧向力分布进行了Pushover分析,并与非线性时程分析结果进行了比较。比较结果表明,对于混凝土框架结构直接加层钢框架结构,不同的侧向力分布得到的Pushover分析结果差异较大,与时程分析结果的偏差也较大。

  5. The Influence of Lateral Load Patterns on the Results of Static Pushover Analysis in High-rise Building%侧向荷载分布方式对高层建筑静力弹塑性分析结果的影响

    Institute of Scientific and Technical Information of China (English)

    杨万

    2014-01-01

    Pushover方法作为一种建筑结构弹塑性地震响应的简化近似计算方法和抗震性能评价方法已得到广泛应用。但由于其理论基础不严密,其准确性需要给予必要确认,同时其适用性也受到一定的限值。就侧向荷载分布方式,对静力弹塑性pushover分析结果的影响进行了研究。用四种不同的侧向荷载分布方式,对一栋24层的高层结构进行了分析。分析结果表明:在不同侧向荷载分布方式作用下, pushover分析结果相差很大。就分析结果而言,选择实时模态的荷载分布方式更为合理。%The nonlinear static pushover analysis procedure is now widely used as a simple method to estimate the inelastic seismic response for building structures. However, the accuracy of the method still needs to be validated because of the inherent limitations in its theory. Besides, there are some limitations on the application of this method. In this paper, the influence of lateral load patterns on the results of static pushover analysis has been studied. The static pushover analysis with four different lateral load patterns was applied to a tall building of 24 stories. It is demonstrated that the analysis results may vary significantly under different lateral load patterns. In terms of the analysis results, feasibility load pattern is more reasonable.

  6. Face/core debond fatigue crack growth characterization using the sandwich mixed mode bending specimen

    DEFF Research Database (Denmark)

    Manca, Marcello; Quispitupa, Amilcar; Berggreen, Christian;

    2012-01-01

    Face/core fatigue crack growth in foam-cored sandwich composites is examined using the mixed mode bending (MMB) test method. The mixed mode loading at the debond crack tip is controlled by changing the load application point in the MMB test fixture. Sandwich specimens were manufactured using H45...... critical load, at load ratios of R=0.1 and 0.2. The crack length was determined during fatigue testing using the analytical compliance expression and verified by visual measurements. Fatigue crack growth results revealed higher crack growth rates for mode I dominated loading. For specimens with H45 core...

  7. Hollow-core grating fiber

    Science.gov (United States)

    Barillé, R.; Tajalli, P.; Roy, P.; Ahmadi-kandjani, S.; Kucharski, S.; Ortyl, E.

    2012-02-01

    We propose a new type of hollow-core fiber where the propagation is ensured by a photoinduced self-pattern acting as a surface relief grating (SRG). The SRG is written by launching a suitable laser beam with proper polarization in a capillary glass fiber with the inner surface previously coated with an azopolymer thin film. Such a grating acts as a wavelength/angle dependant reflective mirror and enhances the confinement and the propagation of the light.

  8. Synthesis and properties of ZnO-HMD@ZnO-Fe/Cu core-shell as advanced material for hydrogen storage.

    Science.gov (United States)

    Bouazizi, N; Boudharaa, T; Bargougui, R; Vieillard, J; Ammar, S; Le Derf, F; Azzouz, A

    2017-04-01

    In this paper, a new synthetic strategy towards functionalized ZnO-HMD@ZnO-Fe/Cu core-shell using sol-gel process modified by chemical grafting of hexamethylenediamine (HMD) on the core and in-situ dispersion of Cu(0)/Fe(0) as metallic nanoparticles (M-NPs) on the shell. The as-prepared core-shell materials were fully characterized by transmission electron microscopy, X-ray powder diffractometry, diffuse reflectance and FT-IR spectrophotometery, photoluminescence, and complexes impedance spectroscopy measurements. The XRD patterns agreed with that of the ZnO typical wurtzite structure, indicating good crystallinity of ZnO-HMD@ZnO-Fe/Cu, with the presence of Fe(0) and Cu(0) phases. Hexamethylenediamine grafting and M-NPs insertion were highly activated and enhanced the core and shell interface by the physiochemical interaction. After functionalization, luminescence intensities and electrical properties of both core and core-shell nanoparticles are improved, indicating the effects of the surface groups on the charge transfer of ZnO-HMD@ZnO-Fe/Cu. The hydrogen capacity retention was depended strongly on the composition and structure of the obtained core-shell. Iron/Copper-loaded ZnO-HMD@ZnO materials exhibited the highest capacity for hydrogen storage. The excellent stability and performance of the ZnO-HMD@ZnO-Fe/Cu core-shell make it an efficient candidate for hydrogen storage.

  9. Electrical load detection aparatus

    DEFF Research Database (Denmark)

    2010-01-01

    A load detection technique for a load comprising multiple frequency-dependant sub-loads comprises measuring a representation of the impedance characteristic of the load; providing stored representations of a multiplicity of impedance characteristics of the load; each one of the stored representat...

  10. A nuclear heuristic for application to metaheuristics in-core fuel management optimization

    Energy Technology Data Exchange (ETDEWEB)

    Meneses, Anderson Alvarenga de Moura, E-mail: ameneses@lmp.ufrj.b [COPPE/Federal University of Rio de Janeiro, RJ (Brazil). Nuclear Engineering Program; Dalle Molle Institute for Artificial Intelligence (IDSIA), Manno-Lugano, TI (Switzerland); Gambardella, Luca Maria, E-mail: luca@idsia.c [Dalle Molle Institute for Artificial Intelligence (IDSIA), Manno-Lugano, TI (Switzerland); Schirru, Roberto, E-mail: schirru@lmp.ufrj.b [COPPE/Federal University of Rio de Janeiro, RJ (Brazil). Nuclear Engineering Program

    2009-07-01

    The In-Core Fuel Management Optimization (ICFMO) is a well-known problem of nuclear engineering whose features are complexity, high number of feasible solutions, and a complex evaluation process with high computational cost, thus it is prohibitive to have a great number of evaluations during an optimization process. Heuristics are criteria or principles for deciding which among several alternative courses of action are more effective with respect to some goal. In this paper, we propose a new approach for the use of relational heuristics for the search in the ICFMO. The Heuristic is based on the reactivity of the fuel assemblies and their position into the reactor core. It was applied to random search, resulting in less computational effort concerning the number of evaluations of loading patterns during the search. The experiments demonstrate that it is possible to achieve results comparable to results in the literature, for future application to metaheuristics in the ICFMO. (author)

  11. Contact analysis and load distribution of double-envelop hourglassworm gearing affected by errors and load

    Institute of Scientific and Technical Information of China (English)

    XU Wujiao; QIN Datong; SHI Wankai

    2003-01-01

    An approach for the contact analysis and load distribution of double-envelop hourglass worm gearing is presented,which is based on a 3-D elastic contact finite element method (FEM) model that 3ccommodates the influence of errors and load.As compared with existing tooth contact analysis model that assumes rigidity for the contacting surfaces, the proposed model provides a more realistic analysis on the contact patterns, the distribution of contact load and transmission errors. It is also capable of exploring the influence of different errors on meshing performances, the contact deformation, the shift of the contact zone and load share among the meshing tooth-pairs under different load.

  12. Energy efficiency analysis of reconfigured distribution system for practical loads

    Directory of Open Access Journals (Sweden)

    Pawan Kumar

    2016-09-01

    Full Text Available In deregulated rate structure, the performance evaluation of distribution system for energy efficiency includes; loss minimization, improved power quality, loadability limit, reliability and availability of supply. Energy efficiency changes with the variation in loading pattern and the load behaviour. Further, the nature of load at each node is not explicitly of any one type rather their characteristics depend upon the node voltages. In most cases, load is assumed to be constant power (real and reactive. In this paper voltage dependent practical loads are represented with composite load model and the energy efficiency performance of distribution system for practical loads is evaluated in different configurations of 33-node system.

  13. Target Loading from a Submerged Explosion

    Directory of Open Access Journals (Sweden)

    Andrew Wardlaw

    2010-01-01

    Full Text Available The pressure on a flat plate suspended over a submerged detonation is measured and simulated. Calculation and experiment are in relatively good agreement, although there is variation in experimental results and simulations are sensitive, near the centerline, to the computational details. This sensitivity is linked to the instability of the accelerating plume, typical of a Richtmyer-Meshkov instability. The plate loading features an initial force at plate center, followed by an expanding circular loading pattern. The initial load is due to plume impact, while the circular load arises from the impact of water transported up the edges of the explosion cavity.

  14. Distribution load estimation (DLE)

    Energy Technology Data Exchange (ETDEWEB)

    Seppaelae, A.; Lehtonen, M. [VTT Energy, Espoo (Finland)

    1998-08-01

    The load research has produced customer class load models to convert the customers` annual energy consumption to hourly load values. The reliability of load models applied from a nation-wide sample is limited in any specific network because many local circumstances are different from utility to utility and time to time. Therefore there is a need to find improvements to the load models or, in general, improvements to the load estimates. In Distribution Load Estimation (DLE) the measurements from the network are utilized to improve the customer class load models. The results of DLE will be new load models that better correspond to the loading of the distribution network but are still close to the original load models obtained by load research. The principal data flow of DLE is presented

  15. Tailoring Sandwich Face/Core Interfaces for Improved Damage Tolerance

    DEFF Research Database (Denmark)

    Lundsgaard-Larsen, Christian; Berggreen, Christian; Carlsson, Leif A.

    2010-01-01

    Various modifications of the face/core interface in foam core sandwich specimens are examined in a series of two papers. This paper constitutes part I and describes the finite element analysis of a sandwich test specimen, i.e. a DCB specimen loaded by uneven bending moments (DCB-UBM). Using...

  16. Automated load balancing in the ATLAS high-performance storage software

    CERN Document Server

    Le Goff, Fabrice; The ATLAS collaboration

    2017-01-01

    The ATLAS experiment collects proton-proton collision events delivered by the LHC accelerator at CERN. The ATLAS Trigger and Data Acquisition (TDAQ) system selects, transports and eventually records event data from the detector at several gigabytes per second. The data are recorded on transient storage before being delivered to permanent storage. The transient storage consists of high-performance direct-attached storage servers accounting for about 500 hard drives. The transient storage operates dedicated software in the form of a distributed multi-threaded application. The workload includes both CPU-demanding and IO-oriented tasks. This paper presents the original application threading model for this particular workload, discussing the load-sharing strategy among the available CPU cores. The limitations of this strategy were reached in 2016 due to changes in the trigger configuration involving a new data distribution pattern. We then describe a novel data-driven load-sharing strategy, designed to automatical...

  17. Wind Loads on Structures

    DEFF Research Database (Denmark)

    Dyrbye, Claes; Hansen, Svend Ole

    pressure to structural response) and design criteria. Starting with an introduction of the wind load chain, the book moves on to meteorological considerations, atmospheric boundary layer, static wind load, dynamic wind load and scaling laws used in wind-tunnel tests. The dynamic wind load covers vibrations......Wind loads have to be taken into account when designing civil engineering structures. The wind load on structures can be systematised by means of the wind load chain: wind climate (global), terrain (wind at low height), aerodynamic response (wind load to pressure), mechanical response (wind...

  18. Distribution load estimation - DLE

    Energy Technology Data Exchange (ETDEWEB)

    Seppaelae, A. [VTT Energy, Espoo (Finland)

    1996-12-31

    The load research project has produced statistical information in the form of load models to convert the figures of annual energy consumption to hourly load values. The reliability of load models is limited to a certain network because many local circumstances are different from utility to utility and time to time. Therefore there is a need to make improvements in the load models. Distribution load estimation (DLE) is the method developed here to improve load estimates from the load models. The method is also quite cheap to apply as it utilises information that is already available in SCADA systems

  19. Wind Loads on Structures

    DEFF Research Database (Denmark)

    Dyrbye, Claes; Hansen, Svend Ole

    pressure to structural response) and design criteria. Starting with an introduction of the wind load chain, the book moves on to meteorological considerations, atmospheric boundary layer, static wind load, dynamic wind load and scaling laws used in wind-tunnel tests. The dynamic wind load covers vibrations......Wind loads have to be taken into account when designing civil engineering structures. The wind load on structures can be systematised by means of the wind load chain: wind climate (global), terrain (wind at low height), aerodynamic response (wind load to pressure), mechanical response (wind...

  20. Evaluation of load case ``switch-off of the high pressure pump of the emergency core cooling system``, measures of verification and in situ-test; Einstufung des Lastfalls ``Ausfall der TH-Hochdruckeinspeisepumpe``, Massnahmen zur Verifikation bis hin zum Grossversuch

    Energy Technology Data Exchange (ETDEWEB)

    Trobitz, M.; Mattheis, A. [Kernkraftwerke Gundremmingen Betriebsgesellschaft m.b.H. (Germany); Kerkhof, K.; Hippelein, K. [Stuttgart Univ. (Germany). Staatliche Materialpruefungsanstalt; Gurr-Beyer, C. [Buero fuer Baudynamik, Stuttgart (Germany); Hofstoetter, P. [Technischer Ueberwachungs-Verein Rheinland e.V., Koeln (Germany)

    1998-11-01

    Within the framework of periodic safety inspection of the Gundremmingen power station (RWE-Bayernwerk - KRB II), the load collectives used for the design of safety-relevant systems and components were checked for their consistency with latest updates of the design basis. It was found that there was no analytical information or study available describing a particular process and its effects, namely switch-off of the high-pressure feedwater pump of the emergency core cooling system. The paper reports the work performed for closing the gap, including preparatory analyses, accompanying measures such as vibration measurements during plant shut-down, as well as the preparation and performance of the in-situ test. The experimental results and the comparative evaluation of calculated and experimental data are presented. (orig./CB) [Deutsch] Im Rahmen der periodischen Sicherheitsueberpruefung des Kernkraftwerkes Gundremmingen (Kernkraftwerke RWE-Bayernwerk - KRB II) wurden u.a. die Lastkollektive, die zur Auslegung sicherheitstechnisch relevanter Systeme und Komponenten herangezogen wurden, auf Aktualitaet ueberprueft. Dabei zeigte sich, dass bislang fuer eine Betriebsweise - naemlich das Abschalten der Hochdruckeinspeisepumpe des nuklearen Not- und Nachkuehlsystems (TH-HD-Pumpe) - keine analytischen Untersuchungen vorliegen. Vorbetrachtungen fuer analytische Untersuchungen, begleitende Massnahmen wie Schwingungsmessungen waehrend des Anlagenstillstandes, sowie der Versuchsaufbau und die Versuchsdurchfuehrung des Anlagenversuches werden hier dargestellt. Die Ergebnisse und der Vergleich Rechnung-Messung zum Grossversuch werden in diesem Beitrag vorgestellt. (orig.)

  1. k-core covers and the core

    NARCIS (Netherlands)

    Sanchez-Rodriguez, E.; Borm, Peter; Estevez-Fernandez, A.; Fiestras-Janeiro, G.; Mosquera, M.A.

    2015-01-01

    This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

  2. Academic Rigor: The Core of the Core

    Science.gov (United States)

    Brunner, Judy

    2013-01-01

    Some educators see the Common Core State Standards as reason for stress, most recognize the positive possibilities associated with them and are willing to make the professional commitment to implementing them so that academic rigor for all students will increase. But business leaders, parents, and the authors of the Common Core are not the only…

  3. k-core covers and the core

    NARCIS (Netherlands)

    Sanchez-Rodriguez, E.; Borm, Peter; Estevez-Fernandez, A.; Fiestras-Janeiro, G.; Mosquera, M.A.

    This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

  4. Stereovision measurement of surface deformation of sandwich plates with aluminum foam cores under high speed impact loading%高速冲击荷载作用后泡沫铝夹层板表观变形立体视觉测量

    Institute of Scientific and Technical Information of China (English)

    单宝华; 张博一; 严雨

    2015-01-01

    To measure the surface deformation of sandwich plates with aluminum foam cores under high speed impact loading,a stereovision-based surface deformation measurement method was presented.The normalized gray cross-correlation coefficient with the mean value removed was selected to realize area matching.The maximum and minimum parallactic restrictions were acquired by adjusting the disparity range to eliminate the false parallax,and other four constraints were combined with the former to optimize the disparity map.Then 3D point clouds were calculated according to a parallel binocular stereovision model,and the surface deformation profile curves were acquired by using Delaunay triangulation.Moreover,the stereovision 3D measurement system for surface deformation was integrated based on MATLAB,and the precision and comparison experiments for distance measurement were conducted to testify the validity and reliability of the proposed method.The surface deformation 3D measurement test of aluminum foam cores sandwich plates under high speed impact loading was also performed with the integrated system.The results indicate that the reconstructed 3D surface can accurately display the surface deformation of sandwich plates.Accordingly,a brand new approach is achieved to measure surface deformation of target board under high speed impact loading.%针对高速冲击荷载作用后泡沫铝夹层板表观变形测量需要,研究基于立体视觉的表观变形三维测量方法。选择去均值归一化灰度互相关系数(NCCC)进行区域匹配,通过调整视差范围消除虚假误差,以实现最大最小视差约束;并综合使用5种约束优化视差图。据平行双目立体视觉模型计算三维点云坐标,用 Delaunay 三角剖分获得表观变形曲面。基于 MATLAB 平台集成表观变形立体视觉三维测量系统,进行距离测量精度及比较试验证明该方法的有效性及可靠性。用集成系统完成高速冲击荷载作

  5. Combined Loadings and Cross-Dimensional Loadings Timeliness of Presentation of Financial Statements of Local Government

    Science.gov (United States)

    Muda, I.; Dharsuky, A.; Siregar, H. S.; Sadalia, I.

    2017-03-01

    This study examines the pattern of readiness dimensional accuracy of financial statements of local government in North Sumatra with a routine pattern of two (2) months after the fiscal year ends and patterns of at least 3 (three) months after the fiscal year ends. This type of research is explanatory survey with quantitative methods. The population and the sample used is of local government officials serving local government financial reports. Combined Analysis And Cross-Loadings Loadings are used with statistical tools WarpPLS. The results showed that there was a pattern that varies above dimensional accuracy of the financial statements of local government in North Sumatra.

  6. The effect of the internal structure of Mars on its seasonal loading deformations

    Science.gov (United States)

    Métivier, Laurent; Karatekin, Özgur; Dehant, Véronique

    2008-04-01

    Mars is continuously subjected to surface loading induced by seasonal mass changes in the atmosphere and ice caps due to the CO 2 sublimation and condensation process. It results in surface deformations and in time variations of gravity. Large wavelength annual and semi-annual variations of gravity (particularly zonal coefficients ΔJ) have been determined using present day geodetic satellite measurements. However loading deformations have been poorly studied for a planet like Mars. In this paper, we compute these deformations and their effect on spacecraft orbiting around Mars. Loading deformations of terrestrial planet are typically investigated assuming a spherical planet, radially symmetric. The mean radial structure of Mars is not well known. In particular the radius of the liquid or solid core remains not precisely determined. One may then wonder what is the effect of these uncertainties on loading deformations. Moreover, Mars presents a strong topography and probably large lateral variations of crustal thickness (relative to the Earth). The paper answer the questions of what is the effect of such lateral heterogeneities on surface deformations, and is the classical way to calculate loading deformation well adapted for a planet like Mars. In order to answer these questions we have investigated theoretically loading deformations of Mars-like planets. We first investigated classical load Love numbers. We show that for degrees inferior to 10, the load Love numbers mainly depend on the radius of the core and on its state, and that for degree greater than 10, they depend on the mean radius of mantle-crust interface. Using a General Circulation Model (GCM) of atmosphere and ice caps dynamics we show that loading vertical displacements have a 4-5 cm magnitude and present a North-South pattern with periodic transitions. Finally we investigated the effect of lateral variations of the crustal thickness on these loading deformations. We show that thickness

  7. Thermal behavior of a titanium honeycomb-core sandwich panel

    Science.gov (United States)

    Ko, William L.; Jackson, Raymond H.

    1991-01-01

    Finite element thermal stress analysis was performed on a rectangular titanium honecomb-core sandwich panel which is subjected to thermal load with a temperature gradient across its depth. The distributions of normal stresses in the face sheets and the face-sheet/sandwich-core interfacial shear stresses are presented. The thermal buckling of the heated face sheet was analyzed by assuming the face sheet to be resting on an elastic foundation representing the sandwich core. Thermal buckling curves and thermal buckling load surface are presented for setting the limit for temperature gradient across the panel depth.

  8. Optimal Load Response to Time-of-Use Power Price for Demand Side Management in Denmark

    DEFF Research Database (Denmark)

    Hu, Weihao; Chen, Zhe; Bak-Jensen, Birgitte

    2010-01-01

    -of-use power price for demand side management in order to save the energy costs as much as possible. 3 typical different kinds of loads (industrial load, residential load and commercial load) in Denmark are chosen as study cases. The energy costs decrease up to 9.6% with optimal load response to time......-of-use power price for different loads. Simulation results show that the optimal load response to time-of-use power price for demand side management generates different load profiles and reduces the load peaks. This kind of load patterns may also have significant effects on the power system normal operation....

  9. Geometric Growing Patterns: What's the Rule?

    Science.gov (United States)

    Hourigan, Mairéad; Leavy, Aisling

    2015-01-01

    While within a geometric repeating pattern, there is an identifiable core which is made up of objects that repeat in a predictable manner, a geometric growing pattern (also called visual or pictorial growing patterns in other curricula) "is a pattern that is made from a sequence of figures [or objects] that change from one term to the next in…

  10. Core-shell microparticles for protein sequestration and controlled release of a protein-laden core.

    Science.gov (United States)

    Rinker, Torri E; Philbrick, Brandon D; Temenoff, Johnna S

    2016-12-21

    Development of multifunctional biomaterials that sequester, isolate, and redeliver cell-secreted proteins at a specific timepoint may be required to achieve the level of temporal control needed to more fully regulate tissue regeneration and repair. In response, we fabricated core-shell heparin-poly(ethylene-glycol) (PEG) microparticles (MPs) with a degradable PEG-based shell that can temporally control delivery of protein-laden heparin MPs. Core-shell MPs were fabricated via a re-emulsification technique and the number of heparin MPs per PEG-based shell could be tuned by varying the mass of heparin MPs in the precursor PEG phase. When heparin MPs were loaded with bone morphogenetic protein-2 (BMP-2) and then encapsulated into core-shell MPs, degradable core-shell MPs initiated similar C2C12 cell alkaline phosphatase (ALP) activity as the soluble control, while non-degradable core-shell MPs initiated a significantly lower response (85+19% vs. 9.0+4.8% of the soluble control, respectively). Similarly, when degradable core-shell MPs were formed and then loaded with BMP-2, they induced a ∼7-fold higher C2C12 ALP activity than the soluble control. As C2C12 ALP activity was enhanced by BMP-2, these studies indicated that degradable core-shell MPs were able to deliver a bioactive, BMP-2-laden heparin MP core. Overall, these dynamic core-shell MPs have the potential to sequester, isolate, and then redeliver proteins attached to a heparin core to initiate a cell response, which could be of great benefit to tissue regeneration applications requiring tight temporal control over protein presentation.

  11. Comodules over semiperfect corings

    CERN Document Server

    Caenepeel, S

    2011-01-01

    We discuss when the Rat functor associated to a coring satisfying the left $\\alpha$-condition is exact. We study the category of comodules over a semiperfect coring. We characterize semiperfect corings over artinian rings and over qF-rings.

  12. Coring Sample Acquisition Tool

    Science.gov (United States)

    Haddad, Nicolas E.; Murray, Saben D.; Walkemeyer, Phillip E.; Badescu, Mircea; Sherrit, Stewart; Bao, Xiaoqi; Kriechbaum, Kristopher L.; Richardson, Megan; Klein, Kerry J.

    2012-01-01

    A sample acquisition tool (SAT) has been developed that can be used autonomously to sample drill and capture rock cores. The tool is designed to accommodate core transfer using a sample tube to the IMSAH (integrated Mars sample acquisition and handling) SHEC (sample handling, encapsulation, and containerization) without ever touching the pristine core sample in the transfer process.

  13. Magnetic induction measurements in distribution transformer cores

    Energy Technology Data Exchange (ETDEWEB)

    Paraskevopoulos, A.A.P.; Bourkas, P.D. [National Technical Univ. of Athens, Athens (Greece). Computer Engineering, High Voltage, and Electrical Measurements Laboratory; Paparigas, D. [Schneider ELVIM Electric Transformer Factory, Athens (Greece)

    2005-07-01

    Transformers need high magnetic field rates in order to operate efficiently. In this study, magnetic induction measurements of distribution transformer cores with power levels of 630 kVA were used to assess the performance of transformers in a city in Greece. A 630 kVA transformer was used to investigate whether magnetic induction measurements of the iron core arcs of the transformer were similar to the rest of the transformer's magnetic rate. Potential load losses were also investigated. Eight cores of 4 different sizes were measured in the study. Voltage transmissions were varied in order to measure the different cores. The voltage transmitted into the coil was calculated in order to compare the transformer's magnetic field with the cores. Average values for the measured cores were then calculated. Leakages were measured using a Gauss meter. Results of the study indicated that the measured values were lower than established safety limits for transformers. It was concluded that the magnetic induction measurements of transformer cores can be used to measure the overall performance of transformers. 18 refs., 8 tabs., 5 figs.

  14. Dental responsibility loadings and the relative value of dental services.

    Science.gov (United States)

    Teusner, D N; Ju, X; Brennan, D S

    2017-09-01

    To estimate responsibility loadings for a comprehensive list of dental services, providing a standardized unit of clinical work effort. Dentists (n = 2500) randomly sampled from the Australian Dental Association membership (2011) were randomly assigned to one of 25 panels. Panels were surveyed by questionnaires eliciting responsibility loadings for eight common dental services (core items) and approximately 12 other items unique to that questionnaire. In total, loadings were elicited for 299 items listed in the Australian Dental Schedule 9th Edition. Data were weighted to reflect the age and sex distribution of the workforce. To assess reliability, regression models assessed differences in core item loadings by panel assignment. Estimated loadings were described by reporting the median and mean. Response rate was 37%. Panel composition did not vary by practitioner characteristics. Core item loadings did not vary by panel assignment. Oral surgery and endodontic service areas had the highest proportion (91%) of services with median loadings ≥1.5, followed by prosthodontics (78%), periodontics (76%), orthodontics (63%), restorative (62%) and diagnostic services (31%). Preventive services had median loadings ≤1.25. Dental responsibility loadings estimated by this study can be applied in the development of relative value scales. © 2017 Australian Dental Association.

  15. Neural simulations on multi-core architectures

    Directory of Open Access Journals (Sweden)

    Hubert Eichner

    2009-07-01

    Full Text Available Neuroscience is witnessing increasing knowledge about the anatomy and electrophysiological properties of neurons and their connectivity, leading to an ever increasing computational complexity of neural simulations. At the same time, a rather radical change in personal computer technology emerges with the establishment of multi-cores: high-density, explicitly parallel processor architectures for both high performance as well as standard desktop computers. This work introduces strategies for the parallelization of biophysically realistic neural simulations based on the compartmental modeling technique and results of such an implementation, with a strong focus on multi-core architectures and automation, i. e. user-transparent load balancing.

  16. Banded transformer cores

    Science.gov (United States)

    Mclyman, C. W. T. (Inventor)

    1974-01-01

    A banded transformer core formed by positioning a pair of mated, similar core halves on a supporting pedestal. The core halves are encircled with a strap, selectively applying tension whereby a compressive force is applied to the core edge for reducing the innate air gap. A dc magnetic field is employed in supporting the core halves during initial phases of the banding operation, while an ac magnetic field subsequently is employed for detecting dimension changes occurring in the air gaps as tension is applied to the strap.

  17. High Power Disk Loaded Guide Load

    Energy Technology Data Exchange (ETDEWEB)

    Farkas, Z.D.; /SLAC

    2006-02-22

    A method to design a matching section from a smooth guide to a disk-loaded guide, using a variation of broadband matching, [1, 2] is described. Using this method, we show how to design high power loads. The load consists of a disk-loaded coaxial guide operating in the TE{sub 01}-mode. We use this mode because it has no electric field terminating on a conductor, has no axial currents, and has no current at the cylinder-disk interface. A high power load design that has -35 dB reflection and a 200 MHz, -20 dB bandwidth, is presented. It is expected that it will carry the 600 MW output peak power of the pulse compression network. We use coaxial geometry and stainless steel material to increase the attenuation per cell.

  18. Comparison of Deterministic and Probabilistic Radial Distribution Systems Load Flow

    Science.gov (United States)

    Gupta, Atma Ram; Kumar, Ashwani

    2017-08-01

    Distribution system network today is facing the challenge of meeting increased load demands from the industrial, commercial and residential sectors. The pattern of load is highly dependent on consumer behavior and temporal factors such as season of the year, day of the week or time of the day. For deterministic radial distribution load flow studies load is taken as constant. But, load varies continually with a high degree of uncertainty. So, there is a need to model probable realistic load. Monte-Carlo Simulation is used to model the probable realistic load by generating random values of active and reactive power load from the mean and standard deviation of the load and for solving a Deterministic Radial Load Flow with these values. The probabilistic solution is reconstructed from deterministic data obtained for each simulation. The main contribution of the work is: - Finding impact of probable realistic ZIP load modeling on balanced radial distribution load flow. - Finding impact of probable realistic ZIP load modeling on unbalanced radial distribution load flow. - Compare the voltage profile and losses with probable realistic ZIP load modeling for balanced and unbalanced radial distribution load flow.

  19. On Load Shedding in Complex Event Processing

    OpenAIRE

    2013-01-01

    Complex Event Processing (CEP) is a stream processing model that focuses on detecting event patterns in continuous event streams. While the CEP model has gained popularity in the research communities and commercial technologies, the problem of gracefully degrading performance under heavy load in the presence of resource constraints, or load shedding, has been largely overlooked. CEP is similar to "classical" stream data management, but addresses a substantially different class of queries. Thi...

  20. Preparation and in Vitro Release of Self-Assembled Neurotoxin-Loaded Nanoparticles of Core-Shell Type%神经毒素自组装核壳型纳米粒的制备及其体外释药研究

    Institute of Scientific and Technical Information of China (English)

    柳琳; 徐陆忠; 何晓玮; 赵燕敏; 冯健; 李范珠

    2009-01-01

    目的 制备亲水性多肽类药物神经毒素的自组装核壳型纳米粒,并对其理化性质及体外释药特性进行考察.方法 以聚乙二醇一聚氰基丙烯酸乙酯嵌段共聚物(PEG-g-PECA)为载体,乳化聚合法制备神经毒素自组装核壳型纳米粒,采用正交实验优化制备工艺,制得的核壳型纳米粒通过透射电镜、Zeta电位/粒度分布仪考察理化性质,并用透析袋法分别研究其在pH 7.4和6.8的PBS缓冲液中的体外释药特性.结果 PEG-g-PECA能包埋亲水性多肽神经毒素,制备的神经毒素自组装核壳型纳米粒粒径为(89.6±8.9)mm,多分散系数为(0.110±0.003),包封率为(58.43±0.62)%,Zeta电位为(-38.81±0.47)mV;在pH 7.4和6.8的PBS缓冲液中的体外释药行为均符合Weibull方程,分别为lnln[1/(1-Q)]=0.474Int-1.612 1,r=0.994 6(pH 7.4)及lnln[1/(1-Q)]=0.351Int-0.827 1,r=0.970 8(pH 6.8).结论 以PEG-g-PECA为载体制备亲水性多肽类药物自组装核壳型纳米粒方法可行,所得纳米粒包封率较高,理化性质稳定,体外释药具有缓释制剂特征.%OBJECTIVE To prepare the self-assembled neurotoxin-loaded nanoparticles of core-shell type, and investigate its physicochemical properties and release behavior in vitro. METHODS The self-assembled neurotoxin-loaded nanoparticles of core-shell type were prepared with PEG-g-PECA by emulsion polymerization method. The orthogonal design was used to optimize the preparation technology. The transmission electron microscope(TEM) and Zeta sizer instrument were utilized to investigate the physicochemical properties of the nanoparticles, and the drug release behavior in PBS buffer at pH 7.4 and 6.8 in vitro were studied by dialysis method respectively. RESULTS The mean diameter of the nanoparticles were (89.6±8.9)nm with polydispersity index of (0.110±0.003). The entrapment efficiency was (58.43±0.62)%, and Zeta potential was (-38.81±0.47) inV. The in vitro release profiles of the nanoparticles in pH 7

  1. Fabrication and Testing of Carbon Fiber Reinforced Truss Core Sandwich Panels

    Institute of Scientific and Technical Information of China (English)

    Bing Wang; Linzhi Wu; Li Ma; Qiang Wang; Shanyi Du

    2009-01-01

    Truss core sandwich panels reinforced by carbon fibers were assembled with bonded laminate facesheets and carbon fiber reinforced truss cores. The top and bottom facesheets were interconnected with truss cores. Both ends of the truss cores were embedded into four layers of top and bottom facesheets. The mechanical properties of truss core sandwich panels were then investigated under out-of-plane and in-plane compression loadings to reveal the failure mechanisms of sandwich panels. Experimental results indicated that the mechanical behavior of sandwich structure under in-plane loading is dominated by the buckling and debonding of facesheets.

  2. The use of downstream sediment mini-cores to indicate changes through time in the spatial pattern and process contribution of erosion within a small, selectively logged rainforest catchment in Sabah, Malaysian Borneo

    Science.gov (United States)

    Williams, R. E.; Walsh, R. P. D.; Coombs, T. J.; Bidin, K.; Blake, W. H.

    2012-04-01

    Multi-proxy sediment fingerprinting (using changes in geochemical variables within downstream floodplain or lateral bench cores and relating them to differences in geochemical character of upstream tributary sediment inputs and/or down soil profiles, preferably in combination with dating using Pb-210 and Cs-137) provides the potential for assessing changes in sediment sources through time. This has rarely been done in tropical rainforest catchments, but needs to be tested at a variety of spatial scales. This poster paper presents the results of an attempt to use mini-cores of bankside sediment to explore changes through post-logging time in the relative contributions made by different sub-catchments to the sediment budget of a small (0.44 sq.km.) Baru catchment (selectively logged in the first half of 1989) in the Danum Valley area of Sabah, Malaysian Borneo. The catchment provides a good testing ground for the technique, as it has been monitored for slope erosion and stream suspended sediment transport continuously from before logging to the present day. The research design comprised (1) sampling (at 2 cm vertical intervals) fluvially deposited sediment down replicated pit profiles at three bankside locations at the downstream end of the catchment between the long-term gauging station and the confluence with a higher-order stream: (2) sampling of the finer bed-sediment the three principal tributaries (2West, 2Middle and 2East) and of surface, sub-surface and deep surface soil material from soil pits and road-cuttings across the catchment; (3) geochemical analysis of the graphical and statistical analysis of the data. Pit 1 (34 cm deep) was considered to provide the longest and most dependable sediment record and marked changes in the levels of some elements were detected, with Mn, Fe, Ti and Zr proving to be the most useful. Local spatial variations within the soil geochemistry dataset proved too great for changes in core geochemistry to be linked conclusively to

  3. Sensitivity Analysis of Core Neutronic Parameters in Electron Accelerator-driven Subcritical Advanced Liquid Metal Reactor

    Directory of Open Access Journals (Sweden)

    Marziye Ebrahimkhani

    2016-02-01

    Full Text Available Calculation of the core neutronic parameters is one of the key components in all nuclear reactors. In this research, the energy spectrum and spatial distribution of the neutron flux in a uranium target have been calculated. In addition, sensitivity of the core neutronic parameters in accelerator-driven subcritical advanced liquid metal reactors, such as electron beam energy (Ee and source multiplication coefficient (ks, has been investigated. A Monte Carlo code (MCNPX_2.6 has been used to calculate neutronic parameters such as effective multiplication coefficient (keff, net neutron multiplication (M, neutron yield (Yn/e, energy constant gain (G0, energy gain (G, importance of neutron source (φ∗, axial and radial distributions of neutron flux, and power peaking factor (Pmax/Pave in two axial and radial directions of the reactor core for four fuel loading patterns. According to the results, safety margin and accelerator current (Ie have been decreased in the highest case of ks, but G and φ∗ have increased by 88.9% and 21.6%, respectively. In addition, for LP1 loading pattern, with increasing Ee from 100 MeV up to 1 GeV, Yn/e and G improved by 91.09% and 10.21%, and Ie and Pacc decreased by 91.05% and 10.57%, respectively. The results indicate that placement of the Np–Pu assemblies on the periphery allows for a consistent keff because the Np–Pu assemblies experience less burn-up.

  4. Handball load and shoulder injury rate

    DEFF Research Database (Denmark)

    Møller, M; Nielsen, R O; Attermann, J

    2017-01-01

    Background Knowledge of injury patterns, an essential step towards injury prevention, is lacking in youth handball. Aim To investigate if an increase in handball load is associated with increased shoulder injury rates compared with a minor increase or decrease, and if an association is influenced...... by scapular control, isometric shoulder strength or glenohumeral range of motion (ROM). Methods 679 players (14-18 years) provided weekly reports on shoulder injury and handball load (training and competition hours) over 31 weeks using the SMS, phone and medical examination system. Handball load in a given...... was performed at baseline and midseason. Results An increase in handball load by >60% was associated with greater shoulder injury rate (HR 1.91; 95% CI 1.00 to 3.70, p=0.05) compared with the reference group. The effect of an increase in handball load between 20% and 60% was exacerbated among players...

  5. Core design and optimization of high performance low sodium void 1000 MWe heterogeneous oxide LMFBR cores

    Energy Technology Data Exchange (ETDEWEB)

    Barthold, W.P.; Orechwa, Y.; Su, S.F.; Beitel, J.C.; Turski, R.; Lam, P.S.K.; Fuller, E.L.

    1979-01-01

    Radially heterogeneous core configurations are effective means to reduce sodium void reactivity. In general, radially heterogeneous cores can be designed as tightly or loosely coupled cores with center core or center blanket arrangements. Core height, number of core regions and number of fuel pins per assembly are additional variables in an optimization of basic heterogeneous core configurations. An extensive study was carried out to optimize the core configurations for 1000 MWe LMFBRs. All cores were subject to a common set of nuclear, mechanical, and thermal-hydraulic design assumptions. They were restrained by an upper sodium void reactivity limit of $2.50 and a doubling time of approximately 15 to 18 years. The screening and optimization procedures employed lead to two core layouts which were both tightly coupled. A complete nuclear analysis of these two cores (derived from a loosely coupled configuration/derived from a tightly coupled configuration) determined the fissile inventories (4268.4/4213.4 kg at BOEC), burnups (83.90/100.7 MWd/t peak), reactivity swings (0.49/1.8% ..delta..k total), power and flux distributions for different control insertion patterns, the breeding performance (15.7/15.3 yrs CSDT), the safety parameters, such as sodium void reactivity ($2.38/$2.23 at EOEC), isothermal Doppler coefficients for both sodium-in (45.6/46.1 T dk/dT x 10/sup -4/ core at EOEC) and sodium-out conditions (28.6/28.2 T dk/dT x 10/sup -4/ core at EOEC), and the transient behavior which shows very little space-dependence during a 60 cent reactivity step insertion.

  6. Lightening the Load

    OpenAIRE

    Remington, Anna M.; Swettenham, John G.; Lavie, Nilli

    2012-01-01

    Autism spectrum disorder (ASD) research portrays a mixed picture of attentional abilities with demonstrations of enhancements (e.g., superior visual search) and deficits (e.g., higher distractibility). Here we test a potential resolution derived from the Load Theory of Attention (e.g., Lavie, 2005). In Load Theory, distractor processing depends on the perceptual load of the task and as such can only be eliminated under high load that engages full capacity. We hypothesize that ASD involves enh...

  7. The effect of core configuration on temperature coefficient of reactivity in IRR-1

    Energy Technology Data Exchange (ETDEWEB)

    Bettan, M.; Silverman, I.; Shapira, M.; Nagler, A. [Soreq Nuclear Research Center, Yavne (Israel)

    1997-08-01

    Experiments designed to measure the effect of coolant moderator temperature on core reactivity in an HEU swimming pool type reactor were performed. The moderator temperature coefficient of reactivity ({alpha}{sub {omega}}) was obtained and found to be different in two core loadings. The measured {alpha}{sub {omega}} of one core loading was {minus}13 pcm/{degrees}C at the temperature range of 23-30{degrees}C. This value of {alpha}{sub {omega}} is comparable to the data published by the IAEA. The {alpha}{sub {omega}} measured in the second core loading was found to be {minus}8 pcm/{degrees}C at the same temperature range. Another phenomenon considered in this study is core behavior during reactivity insertion transient. The results were compared to a core simulation using the Dynamic Simulator for Nuclear Power Plants. It was found that in the second core loading factors other than the moderator temperature influence the core reactivity more than expected. These effects proved to be extremely dependent on core configuration and may in certain core loadings render the reactor`s reactivity coefficient undesirable.

  8. Taking a Load Off.

    Science.gov (United States)

    Kenny, John

    1995-01-01

    Discusses the snow -load capacity of school roofs and how understanding this data aids in planning preventive measures and easing fear of roof collapse. Describes how to determine snow-load capacity, and explains the load-bearing behavior of flat versus sloped roofs. Collapse prevention measures are highlighted. (GR)

  9. Reconstructions of information in visual spatial working memory degrade with memory load.

    Science.gov (United States)

    Sprague, Thomas C; Ester, Edward F; Serences, John T

    2014-09-22

    Working memory (WM) enables the maintenance and manipulation of information relevant to behavioral goals. Variability in WM ability is strongly correlated with IQ [1], and WM function is impaired in many neurological and psychiatric disorders [2, 3], suggesting that this system is a core component of higher cognition. WM storage is thought to be mediated by patterns of activity in neural populations selective for specific properties (e.g., color, orientation, location, and motion direction) of memoranda [4-13]. Accordingly, many models propose that differences in the amplitude of these population responses should be related to differences in memory performance [14, 15]. Here, we used functional magnetic resonance imaging and an image reconstruction technique based on a spatial encoding model [16] to visualize and quantify population-level memory representations supported by multivoxel patterns of activation within regions of occipital, parietal and frontal cortex while participants precisely remembered the location(s) of zero, one, or two small stimuli. We successfully reconstructed images containing representations of the remembered-but not forgotten-locations within regions of occipital, parietal, and frontal cortex using delay-period activation patterns. Critically, the amplitude of representations of remembered locations and behavioral performance both decreased with increasing memory load. These results suggest that differences in visual WM performance between memory load conditions are mediated by changes in the fidelity of large-scale population response profiles distributed across multiple areas of human cortex.

  10. Locoregional deformation pattern of the patellar cartilage after different loading types. High-resolution 3D-MRI volumetry at 3 T in-vivo; Lokoregionaere Deformationsmuster im Patellarknorpel nach unterschiedlichen Belastungsparadigmen. Hochaufloesende 3-D-MR-Volumetrie bei 3 T in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Horng, Annie [University Hospital LMU Munich, Muenchen (Germany). Radiology; Raya, J. [New York Univ. Medical Center, NY (United States). Center of Biomedical Imaging; Klinikum der Ludwig-Maximilians-Universitaet Muenchen, Grosshadern (Germany). Inst. fuer Klinische Radiologie; Zscharn, M. [Klinikum der Ludwig-Maximilians-Universitaet Muenchen, Grosshadern (DE). Inst. fuer Klinische Radiologie] (and others)

    2011-05-15

    Purpose: To analyze locoregional deformation patterns indicative of contact areas in patellar cartilage after different loading exercises. Materials and Methods: 7 healthy patellae were examined in-vivo before and immediately after standardized loading (kneeling, squatting or knee bends) and after 90 minutes of rest using a sagittal 3D-T1-w FLASH WE sequence (22 msec/ 9.8msec/ 15 / 0.3 x 0.3 x 1.5 mm{sup 3}) at 3 T. After cartilage segmentation and 3D reconstruction, voxel-based and global precision errors (PR) were calculated. The former were used to determine significant differences in local cartilage thickness. Voxel-based 2{sigma}-thickness difference maps were calculated to visualize locoregional deformation patterns. Global changes in volume (Vol), mean thickness (mTh) and cartilage-bone-interface area (CBIA) were calculated. Results: The voxel-based PR depended on cartilage thickness (D) ranging from 0.12 - 0.35 mm. For D {>=} 1 mm the RF was < 0.31 mm (< voxel size), and for D {>=} 2 mm, the RF was < 0.22 mm. The global PR was 83 mm{sup 3} (2.4 %) for Vol, 0.06 mm (2.0 %) for mTh and 16 mm{sup 2} (1.4 %) for CBIA. The focal cartilage deformation equaled 14 % of the local thickness reduction. The deformation areas were oval and located in the peripheral medial (more vertically oriented, all exercises) and caudo-lateral (more horizontally oriented, kneeling and knee bends) aspects of the patella and were least pronounced in knee bends. Significant changes for Vol/mTh ranged from 2.1 to 3.7 %. Conclusion: This MRI-based study is the first to identify in-vivo voxel-based patellar cartilage deformation patterns indicating contact and loading zones after kneeling and squatting. These zones are anatomically and functionally plausible and may represent areas where stress induced degeneration and subsequent OA can originate. The data may facilitate understanding of individual knee loading properties and help to improve and validate biomechanical models for the knee

  11. The Lisbon Strategy's Empowerment of Core Executives

    DEFF Research Database (Denmark)

    Borrás, Susana; Peters, B. Guy

    2011-01-01

    advancing (further) centralization and politicization in national patterns of EU policy co-ordination, empowering core executives. The Lisbon Strategy's ideational elements (‘grand’ goals and politically visible targets) as well as organizational requirements (Spring Council, national programming and annual...

  12. Thermohydraulics of LMFBR core catchers

    Science.gov (United States)

    Turland, B. D.

    Characterization of the likely form of fuel debris after an accident, following interaction with sodium in the primary vessel and mechanisms controlling the location of the debris in the primary system is discussed. Heat transfer from particulate to liquid sodium and the development of models predicting the amount of debris that may be retained in a coolable form on a structure are considered. The evaluation of the coolability of the structure itself in post accident conditions, particularly the cooling provided by natural convection alone is treated. The response of structures at elevated temperatures and under high thermal loads is considered. The potential for vessel failure if significant quantities of debris accumulate at the bottom of the vessel is shown. The performance of a flat plate core catcher, or similar structure with good cooling from underneath is evaluated.

  13. The core paradox.

    Science.gov (United States)

    Kennedy, G. C.; Higgins, G. H.

    1973-01-01

    Rebuttal of suggestions from various critics attempting to provide an escape from the seeming paradox originated by Higgins and Kennedy's (1971) proposed possibility that the liquid in the outer core was thermally stably stratified and that this stratification might prove a powerful inhibitor to circulation of the outer core fluid of the kind postulated for the generation of the earth's magnetic field. These suggestions are examined and shown to provide no reasonable escape from the core paradox.

  14. K-core inflation

    OpenAIRE

    Alexander L. Wolman

    2011-01-01

    K-core inflation is a new class of underlying inflation measures. The two most popular measures of underlying inflation are core inflation and trimmed mean inflation. The former removes fixed categories of goods and services (food and energy) from the inflation calculation, and the latter removes fixed percentiles of the weighted distribution of price changes. In contrast, k-core inflation specifies a size of relative price change to be removed from the inflation calculation. Thus, the catego...

  15. Wave loads on offshore wind turbines: Accurate tools and structural response

    DEFF Research Database (Denmark)

    Bredmose, Henrik

    2014-01-01

    Can the design models for offshore wind turbine wave loads be improved? And how will that change the overall load picture? Core questions of the Wave Loads project which was finalised in 2013 with two PhD theses, response calculations for jackets and monopiles, a detailed set of experiments and a3D...

  16. Demonstration of Load-Follow Simulation with VERA-CS and Standalone BISON

    Energy Technology Data Exchange (ETDEWEB)

    Stimpson, Shane G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-01-24

    In this report, load-follow simulations using VERA-CS with one-way coupling to standalone BISON has been demonstrated including both a single rod with a full cycle of load-follow operations and a quarter-core model with a single month of load-follow.

  17. Sediment Core Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides instrumentation and expertise for physical and geoacoustic characterization of marine sediments. DESCRIPTION: The multisensor core logger measures...

  18. Sediment Core Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides instrumentation and expertise for physical and geoacoustic characterization of marine sediments.DESCRIPTION: The multisensor core logger measures...

  19. Spatial electric load forecasting

    CERN Document Server

    Willis, H Lee

    2002-01-01

    Spatial Electric Load Forecasting Consumer Demand for Power and ReliabilityCoincidence and Load BehaviorLoad Curve and End-Use ModelingWeather and Electric LoadWeather Design Criteria and Forecast NormalizationSpatial Load Growth BehaviorSpatial Forecast Accuracy and Error MeasuresTrending MethodsSimulation Method: Basic ConceptsA Detailed Look at the Simulation MethodBasics of Computerized SimulationAnalytical Building Blocks for Spatial SimulationAdvanced Elements of Computerized SimulationHybrid Trending-Simulation MethodsAdvanced

  20. Advanced PWR in-core fuel management with optimized gadolinia fuel designs

    Energy Technology Data Exchange (ETDEWEB)

    Berger, H.D.; Neufert, A. [Siemens AG / Power Generation KWU, Nuclear Fuel Cycle, Erlangen (Germany)

    1999-07-01

    Utilities operating LWRs require fuel assemblies and in-core fuel management service, which ensure safe, flexible and cost-effective production of electricity. With the reliability of the fuel having been always the most important requirement, advanced measures to minimize fuel cycle costs are receiving increasing attention in the light of the pressure on costs within the de-regulated power generation markets. The role of in-core fuel management in supporting the goal to minimize fuel cycle costs consists in the development of more demanding core loading strategies, i.e. in the first place more advanced low leakage loading patterns. A prerequisite for this type of loading pattern is the use of an optimized burnable absorber design. Gadolinia as integrated burnable absorber is a very effective means for limiting the critical boron concentration and power peaking factors. Siemens has accumulated extensive experience with Gd-fuel for almost 20 years with e.g. more than 5500 Gd-FA's delivered for PWRs and irradiated up to 65 MWd/kg{sub HM}. Current development efforts for optimizing Gd-fuel are focused on the reduction of the inherent penalties of today's Gd-Fa designs, i.e. reduced average FA enrichment and heavy metal content as well as residual reactivity binding. The most effective way to overcome these drawbacks is the reduction of the Gd{sub 2}O{sub 3} concentration to values of approximately 2 w/o, for which according to recent measurements of the heat conductivity of modern Gd-fuels the reduction of the fissile content in the Gd-rods is no longer necessary. Various feasibility studies have been performed to evaluate the consequences of low-Gd designs for both Siemens PWRs and Non-Siemens PWRs, for which more restrictive boundary conditions with respect to critical boron concentration and peaking factors have to be fulfilled. These studies as well as the first realization of an extended reactor cycle using a low Gd-Fa reload design confirm that the in-core

  1. Duration of load revisited

    DEFF Research Database (Denmark)

    Hoffmeyer, Preben; Sørensen, John Dalsgaard

    2007-01-01

    were formed. Four groups were subjected to short-term strength tests, and four groups were subjected to long-term tests. Creep and time to failure were moni-tored. Time to failure as a function of stress level was established and the reliability of stress level assessment was discussed. A significant...... mechanosorptive effect was demonstrated both in terms of increased creep and shortening of time to failure. The test results were employed for the calibration of four existing duration of load models. The effect of long-term loading was expressed as the stress level SL50 to cause failure after 50 years of loading...... and of the short-term and long-term strengths. For permanent and imposed library loads, reliability-based estimation of the load duration factor gave almost the same results as direct, deterministic calibration. Keywords: Creep, damage models, duration of load, equal rank assumption, load duration factor, matched...

  2. Comparative Analysis of Baked Effect of Flue-cured Tobacco Loaded by Different Patterns in Bulk Curing Barn%烤烟密集烤房不同装烟方式烘烤效果对比分析

    Institute of Scientific and Technical Information of China (English)

    张警予; 娄元菲; 王文超; 李昂; 董艳辉; 杨彦明; 贺帆; 宫长荣

    2014-01-01

    The comparative tests for the baked effect of flue -cured tobacco loaded by 3 different ways ( hanging rod , tobacco clamping, and dispersal leaf ) were carried out in bulk curing barn .The results indicated that: in comparison with the traditional hanging-rod baking , the dispersal-leaf baking could save labor and energy .The labor efficiency in tobacco -loading of hanging -rod way was basically the same as that of needle -type tobacco-clamping way , but the labor used in tobacco -weaving of the for-mer was 0.39 workers/667 m2 higher than that of the latter .The labor used in all links of dispersal -leaf way was 1.60 workers/667 m2 less than that of hanging -rod way, and 1.21 workers/667 m2 less than that of needle -type tobacco-clamping way.The energy-consumption cost in tobacco -baking of dispersal -leaf way and needle -type tobacco-clamping way was respectively 0.22 and 0.07 yuan/kg lower than that of hanging -rod way.The chemical compositions in the baked tobacco leaves loaded by tobacco -clamping way had the best harmony .The average price of baked dry tobacco leaves of needle -type tobacco-clamping way and dis-persal-leaf way was respectively 0.9 and 0.5 yuan/kg higher than that of hanging -rod way, and the medium-superior proportion of baked tobacco leaves of these two tobacco -loading ways was also higher than that of hanging -rod way .%挂竿、烟夹、散叶等3种装烟方式的烘烤对比试验表明:与传统挂竿烘烤相比,较散叶烘烤省工、节能,挂竿装烟和针式烟夹装烟环节用工效率基本一致,差异不明显,但编烟环节针式烟夹明显省工,总体节省了0.39个工/667 m2;散叶堆积较挂竿的各个环节均明显省工,散叶堆积较挂竿节省了1.60个工/667 m2,较针式烟夹节省用工1.21个工/667 m2。针式烟夹和散叶堆积较挂竿烘烤能耗成本略有降低,散叶堆积干烟较挂竿节省能耗成本0.22元/kg,针式烟夹干烟节省0.07元/kg。烟夹

  3. Face/core interface fracture characterization of mixed mode bending sandwich specimens

    DEFF Research Database (Denmark)

    Quispitupa, Amilcar; Berggreen, Christian; Carlsson, L.A.

    2011-01-01

    application point (lever arm distance). Finite element analysis was performed to determine the mode‐mixity at the crack tip. The results showed that the face/core interface fracture toughness increased with increased mode II loading. Post failure analysis of the fractured specimens revealed that the crack......Debonding of the core from the face sheets is a critical failure mode in sandwich structures. This paper presents an experimental study on face/core debond fracture of foam core sandwich specimens under a wide range of mixed mode loading conditions. Sandwich beams with E‐glass fibre face sheets...... and PVC H45, H100 and H250 foam core materials were evaluated. A methodology to perform precracking on fracture specimens in order to achieve a sharp and representative crack front is outlined. The mixed mode loading was controlled in the mixed mode bending (MMB) test rig by changing the loading...

  4. Fire resistance of extruded hollow-core slabs

    DEFF Research Database (Denmark)

    Hertz, Kristian Dahl; Giuliani, Luisa; Sørensen, Lars Schiøtt

    2016-01-01

    Prefabricated extruded hollow-core slabs are preferred building components for floor structures in several countries. It is therefore important to be able to document the fire resistance of these slabs proving fulfilment of standard fire resistance requirements of 60- and 120 minutes found in most...... national building regulations. The paper presents a detailed analysis of the mechanisms responsible for the loss of load-bearing capacity of hollow-core slabs when exposed to fire. Furthermore, it compares theoretical calculation and assessment according to the structural codes with data derived from...... a standard fire test and from a thorough examination of the comprehensive test documentation available on fire exposed hollow-core slabs. Mechanisms for loss of load-bearing capacity are clarified, and evidence of the fire resistance is found. For the first time the mechanisms responsible for loss of load...

  5. Effect of Horizontal Tied Rebars on Precast Reinforced Concrete Core Walls

    OpenAIRE

    Nakachi, Tadaharu

    2013-01-01

    Multistory core walls installed in high-rise reinforced concrete buildings effectively reduce seismic vibration. On the other hand, precast core walls are considered effective for construction because they can be built more quickly than cast-in-place core walls. In this study, lateral loading tests were conducted on precast wall columns simulating the corner and the area near the corner of the L-shaped precast core wall. The specimen consisted of four square-section precast columns. The verti...

  6. Ice Core Investigations

    Science.gov (United States)

    Krim, Jessica; Brody, Michael

    2008-01-01

    What can glaciers tell us about volcanoes and atmospheric conditions? How does this information relate to our understanding of climate change? Ice Core Investigations is an original and innovative activity that explores these types of questions. It brings together popular science issues such as research, climate change, ice core drilling, and air…

  7. Making an Ice Core.

    Science.gov (United States)

    Kopaska-Merkel, David C.

    1995-01-01

    Explains an activity in which students construct a simulated ice core. Materials required include only a freezer, food coloring, a bottle, and water. This hands-on exercise demonstrates how a glacier is formed, how ice cores are studied, and the nature of precision and accuracy in measurement. Suitable for grades three through eight. (Author/PVD)

  8. Ice Core Investigations

    Science.gov (United States)

    Krim, Jessica; Brody, Michael

    2008-01-01

    What can glaciers tell us about volcanoes and atmospheric conditions? How does this information relate to our understanding of climate change? Ice Core Investigations is an original and innovative activity that explores these types of questions. It brings together popular science issues such as research, climate change, ice core drilling, and air…

  9. Iowa Core Annual Report

    Science.gov (United States)

    Iowa Department of Education, 2015

    2015-01-01

    One central component of a great school system is a clear set of expectations, or standards, that educators help all students reach. In Iowa, that effort is known as the Iowa Core. The Iowa Core represents the statewide academic standards, which describe what students should know and be able to do in math, science, English language arts, and…

  10. Mercury's core evolution

    Science.gov (United States)

    Deproost, Marie-Hélène; Rivoldini, Attilio; Van Hoolst, Tim

    2016-10-01

    Remote sensing data of Mercury's surface by MESSENGER indicate that Mercury formed under reducing conditions. As a consequence, silicon is likely the main light element in the core together with a possible small fraction of sulfur. Compared to sulfur, which does almost not partition into solid iron at Mercury's core conditions and strongly decreases the melting temperature, silicon partitions almost equally well between solid and liquid iron and is not very effective at reducing the melting temperature of iron. Silicon as the major light element constituent instead of sulfur therefore implies a significantly higher core liquidus temperature and a decrease in the vigor of compositional convection generated by the release of light elements upon inner core formation.Due to the immiscibility in liquid Fe-Si-S at low pressure (below 15 GPa), the core might also not be homogeneous and consist of an inner S-poor Fe-Si core below a thinner Si-poor Fe-S layer. Here, we study the consequences of a silicon-rich core and the effect of the blanketing Fe-S layer on the thermal evolution of Mercury's core and on the generation of a magnetic field.

  11. The balance of prickle/spiny-legs isoforms controls the amount of coupling between core and fat PCP systems.

    Science.gov (United States)

    Merkel, Matthias; Sagner, Andreas; Gruber, Franz Sebastian; Etournay, Raphael; Blasse, Corinna; Myers, Eugene; Eaton, Suzanne; Jülicher, Frank

    2014-09-22

    The conserved Fat and Core planar cell polarity (PCP) pathways work together to specify tissue-wide orientation of hairs and ridges in the Drosophila wing. Their components form intracellularly polarized complexes at adherens junctions that couple the polarity of adjacent cells and form global patterns. How Fat and Core PCP systems interact is not understood. Some studies suggest that Fat PCP directly orients patterns formed by Core PCP components. Others implicate oriented tissue remodeling in specifying Core PCP patterns. We use genetics, quantitative image analysis, and physical modeling to study Fat and Core PCP interactions during wing development. We show their patterns change during morphogenesis, undergoing phases of coupling and uncoupling that are regulated by antagonistic Core PCP protein isoforms Prickle and Spiny-legs. Evolving patterns of Core PCP are hysteretic: the early Core PCP pattern is modified by tissue flows and then by coupling to Fat PCP, producing sequential patterns that guide hairs and then ridges. Our data quantitatively account for altered hair and ridge polarity patterns in PCP mutants. Premature coupling between Fat and Core PCP explains altered polarity patterns in pk mutants. In other Core PCP mutants, hair polarity patterns are guided directly by Fat PCP. When both systems fail, hairs still align locally and obey signals associated with veins. Temporally regulated coupling between the Fat and Core PCP systems enables a single tissue to develop sequential polarity patterns that orient distinct morphological structures. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Mars' core and magnetism.

    Science.gov (United States)

    Stevenson, D J

    2001-07-12

    The detection of strongly magnetized ancient crust on Mars is one of the most surprising outcomes of recent Mars exploration, and provides important insight about the history and nature of the martian core. The iron-rich core probably formed during the hot accretion of Mars approximately 4.5 billion years ago and subsequently cooled at a rate dictated by the overlying mantle. A core dynamo operated much like Earth's current dynamo, but was probably limited in duration to several hundred million years. The early demise of the dynamo could have arisen through a change in the cooling rate of the mantle, or even a switch in convective style that led to mantle heating. Presently, Mars probably has a liquid, conductive outer core and might have a solid inner core like Earth.

  13. Asset Management Based Distributed Generation Placement from Load Growth Viewpoint

    Directory of Open Access Journals (Sweden)

    majid ghani varzaneh

    2014-10-01

    Full Text Available In this paper, by presenting the asset management model, it is tried to investigate the importance of distributed generation (DG unit placement from radial distribution system reliability indices sensitivity viewpoint and then DG placement will be carried out. Asset management model is designed and explained to maximize the benefit of distribution companies for invested capital. As the value of distribution system reliability indices depend on customers load pattern, any change in customers load pattern causes changes in distribution system reliability indices. One of the factors that changes customers load pattern, is load growth. With considering that the system hardware characteristics are being constant, the values of reliability indices are also highly dependent on load distribution. Therefore, for assessing the current studies the level of validity and the adequacy of system in future, current load distribution and load growth in future should be studied. In this paper, with optimal placement of DG, it is tried to minimize the distribution system reliability indices sensitivity in accordance with load growth in different load patterns.

  14. Optimisation of load control

    Energy Technology Data Exchange (ETDEWEB)

    Koponen, P. [VTT Energy, Espoo (Finland)

    1998-08-01

    Electricity cannot be stored in large quantities. That is why the electricity supply and consumption are always almost equal in large power supply systems. If this balance were disturbed beyond stability, the system or a part of it would collapse until a new stable equilibrium is reached. The balance between supply and consumption is mainly maintained by controlling the power production, but also the electricity consumption or, in other words, the load is controlled. Controlling the load of the power supply system is important, if easily controllable power production capacity is limited. Temporary shortage of capacity causes high peaks in the energy price in the electricity market. Load control either reduces the electricity consumption during peak consumption and peak price or moves electricity consumption to some other time. The project Optimisation of Load Control is a part of the EDISON research program for distribution automation. The following areas were studied: Optimization of space heating and ventilation, when electricity price is time variable, load control model in power purchase optimization, optimization of direct load control sequences, interaction between load control optimization and power purchase optimization, literature on load control, optimization methods and field tests and response models of direct load control and the effects of the electricity market deregulation on load control. An overview of the main results is given in this chapter

  15. The t-core of an s-core

    OpenAIRE

    Fayers, Matthew

    2010-01-01

    We consider the $t$-core of an $s$-core partition, when $s$ and $t$ are coprime positive integers. Olsson has shown that the $t$-core of an $s$-core is again an $s$-core, and we examine certain actions of the affine symmetric group on $s$-cores which preserve the $t$-core of an $s$-core. Along the way, we give a new proof of Olsson's result. We also give a new proof of a result of Vandehey, showing that there is a simultaneous $s$- and $t$-core which contains all others.

  16. The t-core of an s-core

    OpenAIRE

    Fayers, Matthew

    2010-01-01

    We consider the $t$-core of an $s$-core partition, when $s$ and $t$ are coprime positive integers. Olsson has shown that the $t$-core of an $s$-core is again an $s$-core, and we examine certain actions of the affine symmetric group on $s$-cores which preserve the $t$-core of an $s$-core. Along the way, we give a new proof of Olsson's result. We also give a new proof of a result of Vandehey, showing that there is a simultaneous $s$- and $t$-core which contains all others.

  17. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  18. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  19. Earth's inner core: Innermost inner core or hemispherical variations?

    NARCIS (Netherlands)

    Lythgoe, K. H.; Deuss, A.; Rudge, J. F.; Neufeld, J. A.

    2014-01-01

    The structure of Earth's deep inner core has important implications for core evolution, since it is thought to be related to the early stages of core formation. Previous studies have suggested that there exists an innermost inner core with distinct anisotropy relative to the rest of the inner core.

  20. Earth's inner core: Innermost inner core or hemispherical variations?

    NARCIS (Netherlands)

    Lythgoe, K. H.; Deuss, A.; Rudge, J. F.; Neufeld, J. A.

    2014-01-01

    The structure of Earth's deep inner core has important implications for core evolution, since it is thought to be related to the early stages of core formation. Previous studies have suggested that there exists an innermost inner core with distinct anisotropy relative to the rest of the inner core.

  1. Lower head integrity under steam explosion loads

    Energy Technology Data Exchange (ETDEWEB)

    Theofanous, T.G.; Yuen, W.W.; Angelini, S.; Freeman, K.; Chen, X.; Salmassi, T. [Center for Risk Studies and Safety, Univ. of California, Santa Barbara, CA (United States); Sienicki, J.J.

    1998-01-01

    Lower head integrity under steam explosion loads in an AP600-like reactor design is considered. The assessment is the second part of an evaluation of the in-vessel retention idea as a severe accident management concept, the first part (DOE/ID-10460) dealing with thermal loads. The assessment is conducted in terms of the Risk Oriented Accident Analysis Methodology (ROAAM), and includes the comprehensive evaluation of all relevant severe accident scenarios, melt conditions and timing of release from the core region, fully 3D mixing and explosion wave dynamics, and lower head fragility under local, dynamic loading. All of these factors and brought together in a ROAAM Probabilistic Framework to evaluate failure likelihood. The conclusion is that failure is `physically unreasonable`. (author)

  2. Queuing delays in randomized load balanced networks

    NARCIS (Netherlands)

    Borst, S.C.; et al, not CWI

    2007-01-01

    Valiant’s concept of Randomized Load Balancing (RLB), also promoted under the name ‘two-phase routing’, has previously been shown to provide a cost-effective way of implementing overlay networks that are robust to dynamically changing demand patterns. RLB is accomplished in two steps; in the first s

  3. Physical Properties of Iron in the Inner Core

    CERN Document Server

    Steinle-Neumann, G; Cohen, R E; Steinle-Neumann, Gerd; Stixrude, Lars

    2002-01-01

    The Earth's inner core plays a vital role in the dynamics of our planet and is itself strongly exposed to dynamic processes as evidenced by a complex pattern of elastic structure. To gain deeper insight into the nature of these processes we rely on a characterization of the physical properties of the inner core which are governed by the material physics of its main constituent, iron. Here we review recent research on structure and dynamics of the inner core, focusing on advances in mineral physics. We will discuss results on core composition, crystalline structure, temperature,and various aspects of elasticity. Based on recent computational results, we will show that aggregate seismic properties of the inner core can be explained by temperature and compression effects on the elasticity of pure iron, and use single crystal anisotropy to develop a speculative textural model of the inner core that can explain major aspects of inner core anisotropy.

  4. A multi-objective shuffled frog leaping algorithm for in-core fuel management optimization

    Science.gov (United States)

    Arshi, S. Safaei; Zolfaghari, A.; Mirvakili, S. M.

    2014-10-01

    The efficient operation and in-core fuel management of PWRs are of utmost importance. In the present work, a core reload optimization using Shuffled Frog Leaping (SFL) algorithm is addressed and mapped on nuclear fuel loading pattern optimization. SFL is one of the latest meta-heuristic optimization algorithms which is used for solving the discrete optimization problems and inspired from social behavior of frogs. The algorithm initiates the search from an initial population and carries forward to draw out an optimum result. This algorithm employs the use of memetic evolution by exchanging ideas between the members of the population in each local search. The local search of SFL is similar to particle swarm optimization (PSO) and applying shuffling process accomplishes the information exchange between several local searches to obtain an overall optimum result. To evaluate the proposed technique, Shekel's Foxholes and a VVER-1000 reactor are used as test cases to illustrate performance of SFL. Among numerous neutronic and thermal-hydraulic objectives necessary for a fuel management problem to reach an overall optimum, this paper deals with two neutronic objectives, i.e., maximizing effective multiplication factor and flattening power distribution in the core, to evaluate the capability of applying SFL algorithm for a fuel management problem. The results, convergence rate and reliability of the method are quite promising and show the potential and efficiency of the technique for other optimization applications in the nuclear engineering field.

  5. Anchor Loads on Pipelines

    OpenAIRE

    Wei, Ying

    2015-01-01

    Anchor hooking on a subsea pipeline has been investigated in this thesis. Anchor loads on pipelines is in general a rarely occurring event, however, the severity when it occurs could easily jeopardize the integrity of any pipeline. It is considered as an accidental load in the design of pipelines. Pipeline Loads, limit state criteria and anchor categories are defined by the DNV standards. For pipeline, DNV-OS-F101 (08.2012), Submarine Pipeline Systems is adopted. Offshore standard DNV-RP...

  6. Load induced blindness

    OpenAIRE

    Macdonald, J. S. P.; Lavie, N.

    2008-01-01

    Although the perceptual load theory of attention has stimulated a great deal of research, evidence for the role of perceptual load in determining perception has typically relied oil indirect measures that infer perception from distractor effects on reaction times or neural activity (see N. Lavie, 2005. for a review). Here we varied the level of perceptual load in a letter-search task and assessed its effect oil the conscious perception of a search-irrelevant shape stimulus appearing in the pe...

  7. Concentrated loads on concrete

    DEFF Research Database (Denmark)

    Lorenzen, Karen Grøndahl; Nielsen, Mogens Peter

    1997-01-01

    This report deals with concentrated loads on concrete.A new upper bound solution in the axisymmetrical case of a point load in the center of the end face of a cylinder is developed.Based on previous work dealing with failure mechanisms and upper bound solutions, new approximate formulas are devel......This report deals with concentrated loads on concrete.A new upper bound solution in the axisymmetrical case of a point load in the center of the end face of a cylinder is developed.Based on previous work dealing with failure mechanisms and upper bound solutions, new approximate formulas...

  8. Concentrated loads on concrete

    DEFF Research Database (Denmark)

    Lorenzen, Karen Grøndahl; Nielsen, Mogens Peter

    1997-01-01

    This report deals with concentrated loads on concrete.A new upper bound solution in the axisymmetrical case of a point load in the center of the end face of a cylinder is developed.Based on previous work dealing with failure mechanisms and upper bound solutions, new approximate formulas are devel......This report deals with concentrated loads on concrete.A new upper bound solution in the axisymmetrical case of a point load in the center of the end face of a cylinder is developed.Based on previous work dealing with failure mechanisms and upper bound solutions, new approximate formulas...

  9. Critical Axial Load

    Directory of Open Access Journals (Sweden)

    Walt Wells

    2008-01-01

    Full Text Available Our objective in this paper is to solve a second order differential equation for a long, simply supported column member subjected to a lateral axial load using Heun's numerical method. We will use the solution to find the critical load at which the column member will fail due to buckling. We will calculate this load using Euler's derived analytical approach for an exact solution, as well as Euler's Numerical Method. We will then compare the three calculated values to see how much they deviate from one another. During the critical load calculation, it will be necessary to calculate the moment of inertia for the column member.

  10. Electrical load modeling

    Energy Technology Data Exchange (ETDEWEB)

    Valgas, Helio Moreira; Pinto, Roberto del Giudice R.; Franca, Carlos [Companhia Energetica de Minas Gerais (CEMIG), Belo Horizonte, MG (Brazil); Lambert-Torres, Germano; Silva, Alexandre P. Alves da; Pires, Robson Celso; Costa Junior, Roberto Affonso [Escola Federal de Engenharia de Itajuba, MG (Brazil)

    1994-12-31

    Accurate dynamic load models allow more precise calculations of power system controls and stability limits, which are critical mainly in the operation planning of power systems. This paper describes the development of a computer program (software) for static and dynamic load model studies using the measurement approach for the CEMIG system. Two dynamic load model structures are developed and tested. A procedure for applying a set of measured data from an on-line transient recording system to develop load models is described. (author) 6 refs., 17 figs.

  11. Multifrequency Printed Antennas Loaded with Metamaterial Particles

    Directory of Open Access Journals (Sweden)

    D. Segovia-Vargas

    2009-06-01

    Full Text Available This paper provides a review of printed antennas loaded with metamaterial particles. This novel technique allows developing printed antennas with interesting features such as multifrequency (simultaneous operation over two or more frequency bands and multifunctionality (e. g. radiation pattern diversity. Moreover, compactness is also achieved and the main advantages of conventional printed antennas (light weight, low profile, low cost ... are maintained. Different types of metamaterial-loaded printed antennas are reviewed: printed dipoles and patch antennas. Several prototypes are designed, manufactured and measured showing good results. Furthermore, simple but accurate equivalent models are proposed. These models allow an easy and quick design of metamaterial-loaded printed antennas. Finally, two interesting applications based on the proposed antennas are reviewed: the patch antennas are used as radiating elements of emerging active RFID systems in the microwave band and the metamaterial-loaded printed dipoles are employed to increase the performance of log-periodic arrays.

  12. Integrally cored ceramic investment casting mold fabricated by ceramic stereolithography

    Science.gov (United States)

    Bae, Chang-Jun

    Superalloy airfoils are produced by investment casting (IC), which uses ceramic cores and wax patterns with ceramic shell molds. Hollow cored superalloy airfoils in a gas turbine engine are an example of complex IC parts. The complex internal hollow cavities of the airfoil are designed to conduct cooling air through one or more passageways. These complex internal passageways have been fabricated by a lost wax process requiring several processing steps; core preparation, injection molding for wax pattern, and dipping process for ceramic shell molds. Several steps generate problems such as high cost and decreased accuracy of the ceramic mold. For example, costly tooling and production delay are required to produce mold dies for complex cores and wax patterns used in injection molding, resulting in a big obstacle for prototypes and smaller production runs. Rather than using separate cores, patterns, and shell molds, it would be advantageous to directly produce a mold that has the casting cavity and the ceramic core by one process. Ceramic stereolithography (CerSLA) can be used to directly fabricate the integrally cored ceramic casting mold (ICCM). CerSLA builds ceramic green objects from CAD files from many thin liquid layers of powder in monomer, which are solidified by polymerization with a UV laser, thereby "writing" the design for each slice. This dissertation addresses the integrally cored casting ceramic mold (ICCM), the ceramic core with a ceramic mold shell in a single patternless construction, fabricated by ceramic stereolithography (CerSLA). CerSLA is considered as an alternative method to replace lost wax processes, for small production runs or designs too complex for conventional cores and patterns. The main topic is the development of methods to successfully fabricate an ICCM by CerSLA from refractory silica, as well as related issues. The related issues are the segregation of coarse fused silica powders in a layer, the degree of segregation parameter to

  13. Influence of core sand properties on flow dynamics of core shooting process based on experiment and multiphase simulation

    Directory of Open Access Journals (Sweden)

    Chang-jiang Ni

    2017-03-01

    Full Text Available The influence of core sand properties on flow dynamics was investigated synchronously with various core sands, transparent core-box and high-speed camera. To confirm whether the core shooting process has significant turbulence, the flow pattern of sand particles in the shooting head and core box was reproduced with colored core sands. By incorporating the kinetic theory of granular flow (KTGF, kinetic-frictional constitutive correlation and turbulence model, a two-fluid model (TFM was established to study the flow dynamics of the core shooting process. Two-fluid model (TFM simulations were then performed and a areasonable agreement was achieved between the simulation and experimental results. Based on the experimental and simulation results, the effects of turbulence, sand density, sand diameter and binder ratio were analyzed in terms of filling process, sand volume fraction (αs and sand velocity (Vs.

  14. IGCSE core mathematics

    CERN Document Server

    Wall, Terry

    2013-01-01

    Give your core level students the support and framework they require to get their best grades with this book dedicated to the core level content of the revised syllabus and written specifically to ensure a more appropriate pace. This title has been written for Core content of the revised Cambridge IGCSE Mathematics (0580) syllabus for first teaching from 2013. ? Gives students the practice they require to deepen their understanding through plenty of practice questions. ? Consolidates learning with unique digital resources on the CD, included free with every book. We are working with Cambridge

  15. Core shroud corner joints

    Science.gov (United States)

    Gilmore, Charles B.; Forsyth, David R.

    2013-09-10

    A core shroud is provided, which includes a number of planar members, a number of unitary corners, and a number of subassemblies each comprising a combination of the planar members and the unitary corners. Each unitary corner comprises a unitary extrusion including a first planar portion and a second planar portion disposed perpendicularly with respect to the first planar portion. At least one of the subassemblies comprises a plurality of the unitary corners disposed side-by-side in an alternating opposing relationship. A plurality of the subassemblies can be combined to form a quarter perimeter segment of the core shroud. Four quarter perimeter segments join together to form the core shroud.

  16. Pattern recognition in bioinformatics.

    Science.gov (United States)

    de Ridder, Dick; de Ridder, Jeroen; Reinders, Marcel J T

    2013-09-01

    Pattern recognition is concerned with the development of systems that learn to solve a given problem using a set of example instances, each represented by a number of features. These problems include clustering, the grouping of similar instances; classification, the task of assigning a discrete label to a given instance; and dimensionality reduction, combining or selecting features to arrive at a more useful representation. The use of statistical pattern recognition algorithms in bioinformatics is pervasive. Classification and clustering are often applied to high-throughput measurement data arising from microarray, mass spectrometry and next-generation sequencing experiments for selecting markers, predicting phenotype and grouping objects or genes. Less explicitly, classification is at the core of a wide range of tools such as predictors of genes, protein function, functional or genetic interactions, etc., and used extensively in systems biology. A course on pattern recognition (or machine learning) should therefore be at the core of any bioinformatics education program. In this review, we discuss the main elements of a pattern recognition course, based on material developed for courses taught at the BSc, MSc and PhD levels to an audience of bioinformaticians, computer scientists and life scientists. We pay attention to common problems and pitfalls encountered in applications and in interpretation of the results obtained.

  17. The Insidious Nature of 'Hard-Core' Alternative Conceptions: Implications for the constructivist research programme of patterns in high school students' and pre-service teachers' thinking about ionisation energy

    Science.gov (United States)

    Taber, Keith S.; Tan, Kim Chwee Daniel

    2011-01-01

    The present study contributes to the constructivist research programme (RP) into learning science by comparing patterns in responses from two groups of learners-senior high school students and pre-service teachers-in the same educational context (Singapore), to a diagnostic instrument relating to the topic of ionisation energies. This topic is currently included in the curriculum for 16- to 19-year-old students studying chemistry in Singapore (and elsewhere). The comparison shows that: (1) although graduate pre-service teachers offered some types of incorrect responses less frequently than high school students; (2) they retained high levels of alternative conceptions commonly found among high school students; and (3) of particular note, certain alternative conceptions were found to be more common among the graduates. This suggests the intuitive appeal of certain alternative conceptions is such that they can readily be reproduced down 'generations' of learners. The findings are explored in terms of a range of conceptual resources that have been developed within the constructivist RP. The analysis suggests that the curriculum sets out inappropriate target knowledge for senior high school students, given the nature of the subject matter and the prior learning of the students. It is also suggested that it may be fruitful to consider conceptual learning in terms analogous to the RP found in science, and that from this perspective certain insidious alternative conceptions can be understood as derived from commitments that are taken for granted and protected from explicit challenge by a protective belt of refutable auxiliary conceptions.

  18. Nanosized (mu12-Pt)Pd164-xPtx(CO)72(PPh3)20 (x approximately 7) containing Pt-centered four-shell 165-atom Pd-Pt core with unprecedented intershell bridging carbonyl ligands: comparative analysis of icosahedral shell-growth patterns with geometrically related Pd145(CO)x(PEt3)30 (x approximately 60) containing capped three-shell Pd145 core.

    Science.gov (United States)

    Mednikov, Evgueni G; Jewell, Matthew C; Dahl, Lawrence F

    2007-09-19

    Presented herein are the preparation and crystallographic/microanalytical/magnetic/spectroscopic characterization of the Pt-centered four-shell 165-atom Pd-Pt cluster, (mu(12)-Pt)Pd(164-x)Pt(x)(CO)(72)(PPh(3))(20) (x approximately 7), 1, that replaces the geometrically related capped three-shell icosahedral Pd(145) cluster, Pd(145)(CO)(x)(PEt(3))(30) (x approximately 60), 2, as the largest crystallographically determined discrete transition metal cluster with direct metal-metal bonding. A detailed comparison of their shell-growth patterns gives rise to important stereochemical implications concerning completely unexpected structural dissimilarities as well as similarities and provides new insight concerning possible synthetic approaches for generation of multi-shell metal clusters. 1 was reproducibly prepared in small yields (Pd-Pt anatomy of 1 consists of: (a) shell 1 with the centered (mu(12)-Pt) atom encapsulated by the 12-atom icosahedral Pt(x)Pd(12-x) cage, x = 1.2(3); (b) shell 2 with the 42-atom nu(2) icosahedral Pt(x)Pd(42-x) cage, x = 3.5(5); (c) shell 3 with the anti-Mackay 60-atom semi-regular rhombicosidodecahedral Pt(x)Pd(60-x) cage, x = 2.2(6); (d) shell 4 with the 50-atom nu(2) pentagonal dodecahedral Pd(50) cage. The total number of crystallographically estimated Pt atoms, 8 +/- 3, which was obtained from least-squares (Pt(x)/Pd(1-x))-occupancy analysis of the X-ray data that conclusively revealed the central atom to be pure Pt (occupancy factor, x = 1.00(3)), is fortuitously in agreement with that of 7.6(7) found from an X-ray Pt/Pd microanalysis (WDS spectrometer) on three crystals of 1. Our utilization of this site-occupancy (Pt(x)Pd(1-x))-analysis for shells 1-3 originated from the microanalytical results; otherwise, the presumed metal-core composition would have been (mu(12)-Pt)Pd(164). [Alternatively, the (mu(12)-Pt)M(164) core-geometry of 1 may be viewed as a pseudo-Ih Pt-centered six-shell successive nu(1) polyhedral system, each with

  19. The iron alloys of the Earth's core

    Science.gov (United States)

    Caracas, R.; Verstraete, M. J.; Vargas Calderon, A.; Labrosse, S.; Hernlund, J. W.; Gomi, H.; Ohta, K.; Hirose, K.

    2012-12-01

    We estimate the necessary amount of several light elements - C, S, P, O, Si - as major alloying components to match the observed seismic properties of the Earth's inner core. For this we compute the elastic constants tensors and determine the seismic properties of Fe3X compounds, with X = C, S, P, O and Si, using first-principles calculations. Assuming linear relations and similar temperature corrections of velocities, we obtain as most reasonable silicon and oxygen. We perform the same exercise on Fe-Ni alloys and see a minor effect of Ni on the seismic properties of iron. We compute the electrical conductivity of iron and iron alloys at Earth's core conditions from electron-phonon coupling in the ABINIT implementation. We find an excellent agreement with experimental results for pure hcp iron below 1 mbars. We confidently use our results up to core pressure conditions. We show that the conductivity exhibits saturation at high pressures. We treat in detail the effect of Si on hcp iron and show a marked saturation effect, an increase in anisotropy and a strong dependence with the substitution pattern. The computed values suggest that the outer core should have conductivities in excess of 90 W/K/m, which is considerably larger than current estimates. This implies an inner core younger than 1 bil. years and stratification of the outer core.

  20. Subannual layer variability in Greenland firn cores

    Science.gov (United States)

    Kjær, Helle Astrid; Vallelonga, Paul; Vinther, Bo; Winstrup, Mai; Simonsen, Marius; Maffezzoli, Niccoló; Jensen, Camilla Marie

    2017-04-01

    Ice cores are used to infer information about the past and modern techniques allow for high resolution (CFA) of the ice. Such analysis is often used to inform on annual layers to constrain dating of ice cores, but can also be extended to provide information on sub-annual deposition patterns. In this study we use available high resolution data from multiple shallow cores around Greenland to investigate the seasonality and trends in the most often continuously measured components sodium, insoluble dust, calcium, ammonium and conductivity (or acidity) from 1800 AD to today. We evaluate the similarities and differences between the records and discuss the causes from different sources and transport to deposition and post-deposition effects over differences in measurement set up. Further we add to the array of cores already published with measurements from the newly drilled ReCAP ice core from a coastal ice cap in eastern Greenland and from a shallow core drilled at the high accumulation site at the Greenland South Dome.

  1. Polyhedral patterns

    KAUST Repository

    Jiang, Caigui

    2015-10-27

    We study the design and optimization of polyhedral patterns, which are patterns of planar polygonal faces on freeform surfaces. Working with polyhedral patterns is desirable in architectural geometry and industrial design. However, the classical tiling patterns on the plane must take on various shapes in order to faithfully and feasibly approximate curved surfaces. We define and analyze the deformations these tiles must undertake to account for curvature, and discover the symmetries that remain invariant under such deformations. We propose a novel method to regularize polyhedral patterns while maintaining these symmetries into a plethora of aesthetic and feasible patterns.

  2. Biospecimen Core Resource - TCGA

    Science.gov (United States)

    The Cancer Genome Atlas (TCGA) Biospecimen Core Resource centralized laboratory reviews and processes blood and tissue samples and their associated data using optimized standard operating procedures for the entire TCGA Research Network.

  3. NICHD Zebrafish Core

    Data.gov (United States)

    Federal Laboratory Consortium — The core[HTML_REMOVED]s goal is to help researchers of any expertise perform zebrafish experiments aimed at illuminating basic biology and human disease mechanisms,...

  4. iPSC Core

    Data.gov (United States)

    Federal Laboratory Consortium — The induced Pluripotent Stem Cells (iPSC) Core was created in 2011 to accelerate stem cell research in the NHLBI by providing investigators consultation, technical...

  5. Reference: -300CORE [PLACE

    Lifescience Database Archive (English)

    Full Text Available -300CORE Forde BG, Heyworth A, Pywell J, Kreis M Nucleotide sequence of a B1 hordein gene and the identifica...tion of possible upstream regulatory elements in endosperm storage protein genes fr

  6. INTEGRAL core programme

    Science.gov (United States)

    Gehrels, N.; Schoenfelder, V.; Ubertini, P.; Winkler, C.

    1997-01-01

    The International Gamma Ray Astrophysics Laboratory (INTEGRAL) mission is described with emphasis on the INTEGRAL core program. The progress made in the planning activities for the core program is reported on. The INTEGRAL mission has a nominal lifetime of two years with a five year extension option. The observing time will be divided between the core program (between 30 and 35 percent during the first two years) and general observations. The core program consists of three main elements: the deep survey of the Galactic plane in the central radian of the Galaxy; frequent scans of the Galactic plane in the search for transient sources, and pointed observations of several selected sources. The allocation of the observation time is detailed and the sensitivities of the observations are outlined.

  7. Focusing on Core Business

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    China is regulating state-owned enterprises that are investing outside of their core business realms, concerned that poor investment decisions could lead to loss of state-owned assets, but some doubt the effect of the new regulation

  8. Organizing Core Tasks

    DEFF Research Database (Denmark)

    Boll, Karen

    Civil servants conduct the work which makes welfare states functions on an everyday bases: Police men police, school teachers teach, and tax inspectors inspect. Focus in this paper is on the core tasks of tax inspectors. The paper argues that their core task of securing the collection of revenue...... has remained much the same within the last 10 years. However, how the core task has been organized has changed considerable under the influence of various “organizing devices”. The paper focusses on how organizing devices such as risk assessment, output-focus, effect orientation, and treatment...... projects influence the organization of core tasks within the tax administration. The paper shows that the organizational transformations based on the use of these devices have had consequences both for the overall collection of revenue and for the employees’ feeling of “making a difference”. All in all...

  9. Expression of viral polymerase and phosphorylation of core protein determine core and capsid localization of the human hepatitis B virus.

    Science.gov (United States)

    Deroubaix, Aurélie; Osseman, Quentin; Cassany, Aurélia; Bégu, Dominique; Ragues, Jessica; Kassab, Somar; Lainé, Sébastien; Kann, Michael

    2015-01-01

    Biopsies from patients show that hepadnaviral core proteins and capsids - collectively called core - are found in the nucleus and cytoplasm of infected hepatocytes. In the majority of studies, cytoplasmic core localization is related to low viraemia while nuclear core localization is associated with high viral loads. In order to better understand the molecular interactions leading to core localization, we analysed transfected hepatoma cells using immune fluorescence microscopy. We observed that expression of core protein in the absence of other viral proteins led to nuclear localization of core protein and capsids, while expression of core in the context of the other viral proteins resulted in a predominantly cytoplasmic localization. Analysis of which viral partner was responsible for cytoplasmic retention indicated that the HBx, surface proteins and HBeAg had no impact but that the viral polymerase was the major determinant. Further analysis revealed that ϵ, an RNA structure to which the viral polymerase binds, was essential for cytoplasmic retention. Furthermore, we showed that core protein phosphorylation at Ser 164 was essential for the cytoplasmic core localization phenotype, which is likely to explain differences observed between individual cells.

  10. Personal continuous route pattern mining

    Institute of Scientific and Technical Information of China (English)

    Qian YE; Ling CHEN; Gen-cai CHEN

    2009-01-01

    In the daily life, people often repeat regular routes in certain periods. In this paper, a mining system is developed to find the continuous route patterns of personal past trips. In order to count the diversity of personal moving status, the mining system employs the adaptive GPS data recording and five data filters to guarantee the clean trips data. The mining system uses a client/server architecture to protect personal privacy and to reduce the computational load. The server conducts the main mining procedure but with insufficient information to recover real personal routes. In order to improve the scalability of sequential pattern mining, a novel pattern mining algorithm, continuous route pattern mining (CRPM), is proposed. This algorithm can tolerate the different disturbances in real routes and extract the frequent patterns. Experimental results based on nine persons' trips show that CRPM can extract more than two times longer route patterns than the traditional route pattern mining algorithms.

  11. Short term load forecasting of anomalous load using hybrid soft computing methods

    Science.gov (United States)

    Rasyid, S. A.; Abdullah, A. G.; Mulyadi, Y.

    2016-04-01

    Load forecast accuracy will have an impact on the generation cost is more economical. The use of electrical energy by consumers on holiday, show the tendency of the load patterns are not identical, it is different from the pattern of the load on a normal day. It is then defined as a anomalous load. In this paper, the method of hybrid ANN-Particle Swarm proposed to improve the accuracy of anomalous load forecasting that often occur on holidays. The proposed methodology has been used to forecast the half-hourly electricity demand for power systems in the Indonesia National Electricity Market in West Java region. Experiments were conducted by testing various of learning rate and learning data input. Performance of this methodology will be validated with real data from the national of electricity company. The result of observations show that the proposed formula is very effective to short-term load forecasting in the case of anomalous load. Hybrid ANN-Swarm Particle relatively simple and easy as a analysis tool by engineers.

  12. Evaluation of nuclear characteristics of DCA modification core for sub-critical measurement

    Energy Technology Data Exchange (ETDEWEB)

    Hazama, Taira [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1997-10-01

    Critical experiments were carried out on Deuterium Critical Assembly (DCA) modification core. DCA modification core has two regions, that is, test region and driver region. The test region consists of various types of fuel and moderator, while the driver region remains the same as the original DCA core (ATR simulated core). Critical characteristics were measured with various types of core patterns and were compared with calculated values based on SCALE code system. Monte Calro code KENO was found to be very accurate in the core analysis. The accuracy stays below 0.5 %dk/k in keff even if core configuration is extremely complicated. (author)

  13. Experiment and calculation on seismic behavior of RC composite core walls with concealed steel truss

    Institute of Scientific and Technical Information of China (English)

    Wanlin CAO; Weihua CHANG; Changjun ZHAO; Jianwei ZHANG

    2009-01-01

    To improve the seismic performance of reinforced concrete core walls, reinforced concrete com-posite core walls with concealed steel truss were proposed and systemically investigated. Two 1/6 scale core wall specimens, including a normal reinforced concrete core wall and a reinforced concrete composite core wall with concealed steel truss, were designed. The experimental study on seismic performance under cyclic loading was carried out. The load-carrying capacity, stiffness, ductility,hysteretic behavior and energy dissipation of the core walls were discussed. The test results showed that the seismic performance of core walls is improved greatly by the concealed steel truss. The calculated results were found to agree well with the actual measured ones.

  14. Combination of external loads

    Energy Technology Data Exchange (ETDEWEB)

    Frandsen, S.; Tarp Johansen, N.J.; Joergensen, H. [Forskningscenter Risoe, Roskilde (Denmark); Gravesen, H.; Soerensen, S.L. [Carl Bro, Glostrup (Denmark); Pedersen, J. [Elsam Engineering, Fredericia (Denmark); Zorn, R.; Hvidberg Knudsen, M. [DHI Water and Environment, Hoersholm (Denmark); Voelund, P. [Energi E2, Koebenhavn (Denmark)

    2003-09-01

    The project onbectives have been: To improve and consequently opimise the basis for design of offshore wind turbines. This is done through 1) mapping the wind, wave ice and current as well as correlations of these, and 2) by clarifyring how these external conditions transform into loads. A comprehensive effort has been made to get a thorough understanding of the uncertainties that govern the reliability of wind turbines with respect to wind and wave loading. One of the conclusions is that the reliability of wind turbines is generally lower, than the average reliability of building structures that are subject not only to environmental loads, which are very uncertain, but also imposed loads and self weight, which are less uncertain than the environmental loads. The implication is that, at the moment lower load partial safety factors for onshore wind turbines cannot be recommended. For the combination of wind and wave design loads the problem is twofold: 1). A very conservative design will be generated by simply adding the individual wind and wave design loads disregarding the independence of the short-term fluctuations of wind and wave loads. 2). Characteristic values and partial safety factors for wind and wave loads are not defined similarly. This implies that the reliability levels of turbine support structures subject to purely aerodynamic loads and subject to purely hydrodynamic loads are not identical. For the problem of combining aerodynamic design loads and hydrodynamic design loads two results have been obtained in the project: 1). By simple means a site specific wave load safety factor rendering the same safety level for hydrodynamic loads as for aerodynamic loads is derived, and next, by direct square summation of extreme fluctuations, the wind and wave load safety factors are weighted. 2). Under the assumptions that a deep water site is considered and that the wave loading is a fifty-fifty mix of drag and inertia the same wind and wave load safety factor

  15. Load Induced Blindness

    Science.gov (United States)

    Macdonald, James S. P.; Lavie, Nilli

    2008-01-01

    Although the perceptual load theory of attention has stimulated a great deal of research, evidence for the role of perceptual load in determining perception has typically relied on indirect measures that infer perception from distractor effects on reaction times or neural activity (see N. Lavie, 2005, for a review). Here we varied the level of…

  16. Mapping Critical Loads for Europe. CCE Technical Report no. 1

    NARCIS (Netherlands)

    Hettelingh JP; Downing RJ; de Smet PAM; de Vries W; Schopp W; Chadwick MJ; Kuylenstierna JCI; Gough CA

    1991-01-01

    This first Technical report of the Coordination Center for Effects (CCE) presents European maps of critical loads of actual acidity, sulphur and nitrogen, and maps displaying European geographical patterns of exceedances of current deposition over critical loads. Methods and assumptions used to pro

  17. A Preliminary Study on Bucket Foundations under Transient Lateral Loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo; Nielsen, Søren Kjær;

    2013-01-01

    This study aims at investigating the behaviour of monopod bucket foundations through a physical model. The foundation is installed in dense water-saturated sand and is subjected to lateral load applied at different rates. The different loading rates allow for exploring the patterns of response of...

  18. Encapsulation of methotrexate loaded magnetic microcapsules for magnetic drug targeting and controlled drug release

    Energy Technology Data Exchange (ETDEWEB)

    Chakkarapani, Prabu [Department of Pharmaceutical Technology & Centre for Excellence in Nanobio Translational Research, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli 620024, Tamil Nadu (India); Subbiah, Latha, E-mail: lathasuba2010@gmail.com [Department of Pharmaceutical Technology & Centre for Excellence in Nanobio Translational Research, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli 620024, Tamil Nadu (India); Palanisamy, Selvamani; Bibiana, Arputha [Department of Pharmaceutical Technology & Centre for Excellence in Nanobio Translational Research, Anna University, Bharathidasan Institute of Technology Campus, Tiruchirappalli 620024, Tamil Nadu (India); Ahrentorp, Fredrik; Jonasson, Christian; Johansson, Christer [Acreo Swedish ICT AB, Arvid Hedvalls backe 4, SE-411 33 Göteborg (Sweden)

    2015-04-15

    We report on the development and evaluation of methotrexate magnetic microcapsules (MMC) for targeted rheumatoid arthritis therapy. Methotrexate was loaded into CaCO{sub 3}-PSS (poly (sodium 4-styrenesulfonate)) doped microparticles that were coated successively with poly (allylamine hydrochloride) and poly (sodium 4-styrenesulfonate) by layer-by-layer technique. Ferrofluid was incorporated between the polyelectrolyte layers. CaCO{sub 3}-PSS core was etched by incubation with EDTA yielding spherical MMC. The MMC were evaluated for various physicochemical, pharmaceutical parameters and magnetic properties. Surface morphology, crystallinity, particle size, zeta potential, encapsulation efficiency, loading capacity, drug release pattern, release kinetics and AC susceptibility studies revealed spherical particles of ~3 µm size were obtained with a net zeta potential of +24.5 mV, 56% encapsulation and 18.6% drug loading capacity, 96% of cumulative drug release obeyed Hixson-Crowell model release kinetics. Drug excipient interaction, surface area, thermal and storage stability studies for the prepared MMC was also evaluated. The developed MMC offer a promising mode of targeted and sustained release drug delivery for rheumatoid arthritis therapy. - Highlights: • Development of methotrexate magnetic microcapsules (MMC) by layer-by-layer method. • Characterization of physicochemical, pharmaceutical and magnetic properties of MMC. • Multiple layers of alternative polyelectrolytes prolongs methotrexate release time. • MMC is capable for targeted and sustained release rheumatoid arthritis therapy.

  19. Application Analysis of Strengthened Story in Frame-Core Structures

    Institute of Scientific and Technical Information of China (English)

    SU Yuan; CHEN Chuan-yao; LI Li

    2009-01-01

    Lateral deflection formulas are presented for analysis of the strengthened story applied to frame-core structures. For the frame-core structures with top outriggers and with middle outriggers, the relationship between stiffness characteristic parameters of frame and outriggers and the top drift of structures under different loads is analyzed. It is indicated that when stiffness characteristic parameter of frame is large, outrigger efficiency for top drift reduction is low, and the mutation of internal forces occurs; when the stiffness characteristic parameter of frame is less than 3, installing the strengthened story is advantageous to frame-core structures.

  20. Indentation load relaxation test

    Energy Technology Data Exchange (ETDEWEB)

    Hannula, S.P.; Stone, D.; Li, C.Y. (Cornell Univ., Ithaca, NY (USA))

    Most of the models that are used to describe the nonelastic behavior of materials utilize stress-strain rate relations which can be obtained by a load relaxation test. The conventional load relaxation test, however, cannot be performed if the volume of the material to be tested is very small. For such applications the indentation type of test offers an attractive means of obtaining data necessary for materials characterization. In this work the feasibility of the indentation load relaxation test is studied. Experimental techniques are described together with results on Al, Cu and 316 SS. These results are compared to those of conventional uniaxial load relaxation tests, and the conversion of the load-indentation rate data into the stress-strain rate data is discussed.

  1. Specialization Patterns

    DEFF Research Database (Denmark)

    Schultz, Ulrik Pagh; Lawall, Julia Laetitia; Consel, Charles

    2000-01-01

    Design patterns offer many advantages for software development, but can introduce inefficiency into the final program. Program specialization can eliminate such overheads, but is most effective when targeted by the user to specific bottlenecks. Consequently, we propose that these concepts...... are complementary. Program specialization can optimize programs written using design patterns, and design patterns provide information about the program structure that can guide specialization. Concretely, we propose specialization patterns, which describe how to apply program specialization to optimize uses...... of design patterns. In this paper, we analyze the specialization opportunities provided by specific uses of design patterns. Based on the analysis of each design pattern, we define the associated specialization pattern. These specialization opportunities can be declared using the specialization classes...

  2. Exploratory Analysis of a GGSN’s PDP Context Signaling Load

    Directory of Open Access Journals (Sweden)

    Florian Metzger

    2014-01-01

    Full Text Available This paper takes an exploratory look on control plane signaling in a mobile cellular core network. In contrast to most contributions in this field, our focus does not lie on the wireless or user-oriented parts of the network, but on signaling in the core network. In an investigation of core network data we take a look at statistics related to GTP tunnels and their signaling. Based on the results thereof we propose a definition of load at the GGSN and create an initial load queuing model. We find signs of user devices putting burden on the core network through their behavior.

  3. Construction of linear empirical core models for pressurized water reactor in-core fuel management

    Energy Technology Data Exchange (ETDEWEB)

    Okafor, K.C.; Aldemir, T. (The Ohio State Univ., Dept. of Mechanical Engineering, Nuclear Engineering Program, 206 West 18th Ave., Columbus, OH (US))

    1988-06-01

    An empirical core model construction procedure for pressurized water reactor (PWR) in-core fuel management problems is presented that (a) incorporates the effect of composition changes in all the control zones in the core of a given fuel assembly, (b) is valid at all times during the cycle for a given range of control variables, (c) allows determining the optimal beginning of cycle (BOC) kappainfinity distribution as a single linear programming problem,and (d) provides flexibility in the choice of the material zones to describe core composition. Although the modeling procedure assumes zero BOC burnup, the predicted optimal kappainfinity profiles are also applicable to reload cores. In model construction, assembly power fractions and burnup increments during the cycle are regarded as the state (i.e., dependent) variables. Zone enrichments are the control (i.e., independent) variables. The model construction procedure is validated and implemented for the initial core of a PWR to determine the optimal BOC kappainfinity profiles for two three-zone scatter loading schemes. The predicted BOC kappainfinity profiles agree with the results of other investigators obtained by different modeling techniques.

  4. In vitro evaluation of the fracture strength of all-ceramic core materials on zirconium posts.

    Science.gov (United States)

    Ozcan, Nihal; Sahin, Erdal

    2013-10-01

    For most endodontically treated teeth, tooth-colored post-core systems are preferable for esthetic reasons. Therefore, improvements in material strength must also consider tooth colored post-core complexes. The objective of this study was to evaluate the difference in tooth colored post-core complex strengths. A total of 33 human maxillary central incisor teeth were used for this study, with three groups of 11 teeth. Three different methods were used to fabricate all-ceramic post-core restorations: zirconia blanks, Cerec 3D-milled to one-piece post-core restorations (Test Group 1); feldspathic cores (from feldspathic prefabricated CAD/CAM blocks) adhesively luted to CosmoPost zirconia posts (Test Group 2); and IPS Empress cores directly pressed to CosmoPost zirconia posts (Test Group 3). All-ceramic crowns from feldspathic ceramic were constructed using a CAD/CAM system (Cerec 3D) for all specimens. The post-core complexes were tested to failure with the load applied at 45° angled relative to the tooth long axis. The load at fracture was recorded. The maximum fracture strength of the milled zirconia cores (Test Group 1) was 577 N; corresponding values for the milled feldspathic cores (Test Group 2) and the pressed cores (Test Group 3) were 586 and 585 N, respectively. Differences were not statistically significant at P cores adhesively luted on zirconia posts and one-piece all-ceramic zirconium post-core structures offer a viable alternative to conventional pressing.

  5. Packing in protein cores

    Science.gov (United States)

    Gaines, J. C.; Clark, A. H.; Regan, L.; O'Hern, C. S.

    2017-07-01

    Proteins are biological polymers that underlie all cellular functions. The first high-resolution protein structures were determined by x-ray crystallography in the 1960s. Since then, there has been continued interest in understanding and predicting protein structure and stability. It is well-established that a large contribution to protein stability originates from the sequestration from solvent of hydrophobic residues in the protein core. How are such hydrophobic residues arranged in the core; how can one best model the packing of these residues, and are residues loosely packed with multiple allowed side chain conformations or densely packed with a single allowed side chain conformation? Here we show that to properly model the packing of residues in protein cores it is essential that amino acids are represented by appropriately calibrated atom sizes, and that hydrogen atoms are explicitly included. We show that protein cores possess a packing fraction of φ ≈ 0.56 , which is significantly less than the typically quoted value of 0.74 obtained using the extended atom representation. We also compare the results for the packing of amino acids in protein cores to results obtained for jammed packings from discrete element simulations of spheres, elongated particles, and composite particles with bumpy surfaces. We show that amino acids in protein cores pack as densely as disordered jammed packings of particles with similar values for the aspect ratio and bumpiness as found for amino acids. Knowing the structural properties of protein cores is of both fundamental and practical importance. Practically, it enables the assessment of changes in the structure and stability of proteins arising from amino acid mutations (such as those identified as a result of the massive human genome sequencing efforts) and the design of new folded, stable proteins and protein-protein interactions with tunable specificity and affinity.

  6. Load Balancing Scientific Applications

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, Olga Tkachyshyn [Texas A & M Univ., College Station, TX (United States)

    2014-12-01

    The largest supercomputers have millions of independent processors, and concurrency levels are rapidly increasing. For ideal efficiency, developers of the simulations that run on these machines must ensure that computational work is evenly balanced among processors. Assigning work evenly is challenging because many large modern parallel codes simulate behavior of physical systems that evolve over time, and their workloads change over time. Furthermore, the cost of imbalanced load increases with scale because most large-scale scientific simulations today use a Single Program Multiple Data (SPMD) parallel programming model, and an increasing number of processors will wait for the slowest one at the synchronization points. To address load imbalance, many large-scale parallel applications use dynamic load balance algorithms to redistribute work evenly. The research objective of this dissertation is to develop methods to decide when and how to load balance the application, and to balance it effectively and affordably. We measure and evaluate the computational load of the application, and develop strategies to decide when and how to correct the imbalance. Depending on the simulation, a fast, local load balance algorithm may be suitable, or a more sophisticated and expensive algorithm may be required. We developed a model for comparison of load balance algorithms for a specific state of the simulation that enables the selection of a balancing algorithm that will minimize overall runtime.

  7. Inner core structure behind the PKP core phase triplication

    NARCIS (Netherlands)

    Blom, Nienke A.; Deuss, Arwen; Paulssen, Hanneke; Waszek, Lauren

    2015-01-01

    The structure of the Earth's inner core is not well known between depths of ∼100–200 km beneath the inner core boundary. This is a result of the PKP core phase triplication and the existence of strong precursors to PKP phases, which hinder the measurement of inner core compressional PKIKP waves at e

  8. Inner core structure behind the PKP core phase triplication

    NARCIS (Netherlands)

    Blom, Nienke A.; Deuss, Arwen; Paulssen, Hanneke; Waszek, Lauren

    The structure of the Earth's inner core is not well known between depths of ∼100–200 km beneath the inner core boundary. This is a result of the PKP core phase triplication and the existence of strong precursors to PKP phases, which hinder the measurement of inner core compressional PKIKP waves at

  9. Pressure Core Characterization

    Science.gov (United States)

    Santamarina, J. C.

    2014-12-01

    Natural gas hydrates form under high fluid pressure and low temperature, and are found in permafrost, deep lakes or ocean sediments. Hydrate dissociation by depressurization and/or heating is accompanied by a multifold hydrate volume expansion and host sediments with low permeability experience massive destructuration. Proper characterization requires coring, recovery, manipulation and testing under P-T conditions within the stability field. Pressure core technology allows for the reliable characterization of hydrate bearing sediments within the stability field in order to address scientific and engineering needs, including the measurement of parameters used in hydro-thermo-mechanical analyses, and the monitoring of hydrate dissociation under controlled pressure, temperature, effective stress and chemical conditions. Inherent sampling effects remain and need to be addressed in test protocols and data interpretation. Pressure core technology has been deployed to study hydrate bearing sediments at several locations around the world. In addition to pressure core testing, a comprehensive characterization program should include sediment analysis, testing of reconstituted specimens (with and without synthetic hydrate), and in situ testing. Pressure core characterization technology can be used to study other gas-charged formations such as deep sea sediments, coal bed methane and gas shales.

  10. Data complexity in pattern recognition

    CERN Document Server

    Kam Ho Tin

    2006-01-01

    Machines capable of automatic pattern recognition have many fascinating uses. Algorithms for supervised classification, where one infers a decision boundary from a set of training examples, are at the core of this capability. This book looks at data complexity and its role in shaping the theories and techniques in different disciplines

  11. Shear and anchorage behaviour of fire exposed hollow core slabs

    NARCIS (Netherlands)

    Fellinger, J.H.H.; Stark, J.; Walraven, J.C.

    2005-01-01

    The fire resistance of hollow core slabs is currently assessed considering flexural failure only. However, fire tests showed that shear or anchorage failure can also govern the load bearing behaviour. As the shear and anchorage capacity of these slabs rely on the tensile strength of the concrete, th

  12. Shear and anchorage behaviour of fire exposed hollow core slabs

    NARCIS (Netherlands)

    Fellinger, J.

    2005-01-01

    The fire resistance of hollow core slabs is currently assessed considering flexural failure only. However, fire tests show that shear or anchorage failure can also govern the load bearing behaviour. This paper is based on the dissertation by the author1 and discusses existing and new fire tests. It

  13. Shear and Anchorage Behaviour of Fire Exposed Hollow Core Slabs

    NARCIS (Netherlands)

    Fellinger, J.H.H.

    2004-01-01

    Hollow core (HC) slabs are made of precast concrete with pretensioned strands. These slabs are popular as floor structures in offices and housing. At ambient conditions, the load bearing capacity can be dominated by four different failure modes, i.e. flexure, anchorage, shear compression and shear t

  14. Shear and Anchorage Behaviour of Fire Exposed Hollow Core Slabs

    NARCIS (Netherlands)

    Fellinger, J.H.H.

    2004-01-01

    Hollow core (HC) slabs are made of precast concrete with pretensioned strands. These slabs are popular as floor structures in offices and housing. At ambient conditions, the load bearing capacity can be dominated by four different failure modes, i.e. flexure, anchorage, shear compression and shear

  15. Shear and Anchorage Behaviour of Fire Exposed Hollow Core Slabs

    NARCIS (Netherlands)

    Fellinger, J.H.H.

    2004-01-01

    Hollow core (HC) slabs are made of precast concrete with pretensioned strands. These slabs are popular as floor structures in offices and housing. At ambient conditions, the load bearing capacity can be dominated by four different failure modes, i.e. flexure, anchorage, shear compression and shear t

  16. Evaluation of SMART load follow operation capability

    Energy Technology Data Exchange (ETDEWEB)

    Song, Jae Seung; Zee, Sung Quun

    1998-07-01

    The daily load follow operation capability of SMART, which is 330 MWth integral reactor with boron free operation concept, was evaluated. In the boron free operation core the axial offset(AO) can not be limited or limited by wider range than the typical PWR that uses soluble boron. Current SMART conceptual core design does not have the limit for the axial offset and the operation is limited by three dimensional local power peak. In this report, the capability of load follow operation is evaluated for 14-2-6-2 daily load follow by 50% power reduction that is very typical in the large commercial power reactors. The cycle length of SMART is limited by three dimensional local power peak and the nominal axial power distribution is top skewed at the end of cycle. When the power returns to 100%, control rod should be withdrawn for the compensation of reactivity decrease due to the xenon buildup. The control rod withdrawal results in the increase of three dimensional local power peak. To solve this problem, an operation strategy for the control of local peak. To solve this problem, an operation strategy for the control of local peak was established and it was shown that the strategy is effective in controlling the local peak less than target value of the three dimensional local power peak. (author). 7 refs., 5 tabs., 13 figs.

  17. BNL program in support of LWR degraded-core accident analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ginsberg, T.; Greene, G.A.

    1982-01-01

    Two major sources of loading on dry watr reactor containments are steam generatin from core debris water thermal interactions and molten core-concrete interactions. Experiments are in progress at BNL in support of analytical model development related to aspects of the above containment loading mechanisms. The work supports development and evaluation of the CORCON (Muir, 1981) and MARCH (Wooton, 1980) computer codes. Progress in the two programs is described in this paper. 8 figures.

  18. MOX fuel arrangement for nuclear core

    Science.gov (United States)

    Kantrowitz, Mark L.; Rosenstein, Richard G.

    1998-01-01

    In order to use up a stockpile of weapons-grade plutonium, the plutonium is converted into a mixed oxide (MOX) fuel form wherein it can be disposed in a plurality of different fuel assembly types. Depending on the equilibrium cycle that is required, a predetermined number of one or more of the fuel assembly types are selected and arranged in the core of the reactor in accordance with a selected loading schedule. Each of the fuel assemblies is designed to produce different combustion characteristics whereby the appropriate selection and disposition in the core enables the resulting equilibrium cycle to closely resemble that which is produced using urania fuel. The arrangement of the MOX rods and burnable absorber rods within each of the fuel assemblies, in combination with a selective control of the amount of plutonium which is contained in each of the MOX rods, is used to tailor the combustion characteristics of the assembly.

  19. Nanoengineering of methylene blue loaded silica encapsulated magnetite nanospheres and nanocapsules for photodynamic therapy

    Energy Technology Data Exchange (ETDEWEB)

    Andhariya, Nidhi [Bhavnagar University, Department of Physics (India); Chudasama, Bhupendra, E-mail: bnchudasama@gmail.com [Thapar University, School of Physics and Materials Science (India); Mehta, R. V. [Bhavnagar University, Department of Physics (India); Upadhyay, R. V. [Charotar University of Science and Technology, P.D. Patel Institute of Applied Sciences (India)

    2011-09-15

    Core-shell nanostructures have emerged as an important class of functional materials with potential applications in diverse fields, especially in health sciences. In this article, nanoengineering of novel magnetic colloidal dispersion containing surface modifiable silica with a core of single domain magnetite nanoparticles loaded with photosensitizer (PS) drug 'Methylene blue' (MB) has been described. Magnetite core is produced by the well-established chemical coprecipitation technique and silica shell is formed over it by the modified hydrolysis and condensation of TEOS (tetraethyl orthosilicate). Conditions for reaction kinetics have been established to tailor the core-shell structures in the form of nanospheres and nanocapsules. MB is loaded into the nanostructures by demethylation reaction. The major conclusion drawn from this study is that the synthesis route yields stable, non-aggregated MB loaded superparamagnetic magnetite-silica nanostructures with tailored morphology, tunable loading, and excellent magnetic properties.

  20. Lumbriculus variegatus loading study

    Data.gov (United States)

    U.S. Environmental Protection Agency — Results from sediment bioaccumulation tests with Lumbriculus variegatus with evaluating the effects of organism loading density. This dataset is associated with the...

  1. Carbohydrate-Loading Diet

    Science.gov (United States)

    ... Grape juice (12 ounces) 55 225 Lunch Milk, chocolate, reduced fat (12 ounces) 45 285 4 slices ... of carb-loading for sports performance. Academy of Nutrition and Dietetics. http://www.eatright.org/resource/fitness/ ...

  2. LOADING SIMULATION PROGRAM C

    Data.gov (United States)

    U.S. Environmental Protection Agency — LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for...

  3. Cognitive load theory

    NARCIS (Netherlands)

    Kirschner, Paul A.; Kirschner, Femke; Paas, Fred

    2010-01-01

    Kirschner, P. A., Kirschner, F. C., & Paas, F. (2009). Cognitive load theory. In E. M. Anderman & L. H. Anderman (Eds.). Psychology of classroom learning: An encyclopedia, Volume 1, a-j (pp. 205-209). Detroit, MI: Macmillan Reference.

  4. Static Loads Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides the capability to perform large-scale structural loads testing on spacecraft and other structures. Results from these tests can be used to verify...

  5. Plug Load Data

    Data.gov (United States)

    National Aeronautics and Space Administration — We provide MATLAB binary files (.mat) and comma separated values files of data collected from a pilot study of a plug load management system that allows for the...

  6. GREEN CORE HOUSE

    Directory of Open Access Journals (Sweden)

    NECULAI Oana

    2017-05-01

    Full Text Available The Green Core House is a construction concept with low environmental impact, having as main central element a greenhouse. The greenhouse has the innovative role to use the biomass energy provided by plants to save energy. Although it is the central piece, the greenhouse is not the most innovative part of the Green Core House, but the whole building ensemble because it integrates many other sustainable systems as "waste purification systems", "transparent photovoltaic panels" or "double skin façades".

  7. Birefringent hollow core fibers

    DEFF Research Database (Denmark)

    Roberts, John

    2007-01-01

    Hollow core photonic crystal fiber (HC-PCF), fabricated according to a nominally non-birefringent design, shows a degree of un-controlled birefringence or polarization mode dispersion far in excess of conventional non polarization maintaining fibers. This can degrade the output pulse in many...... and an increased overlap between the polarization modes at the glass interfaces. The interplay between these effects leads to a wavelength for optimum polarization maintenance, lambda(PM), which is detuned from the wavelength of highest birefringence. By a suitable fiber design involving antiresonance of the core...

  8. Birefringent hollow core fibers

    DEFF Research Database (Denmark)

    Roberts, John

    2007-01-01

    Hollow core photonic crystal fiber (HC-PCF), fabricated according to a nominally non-birefringent design, shows a degree of un-controlled birefringence or polarization mode dispersion far in excess of conventional non polarization maintaining fibers. This can degrade the output pulse in many...... and an increased overlap between the polarization modes at the glass interfaces. The interplay between these effects leads to a wavelength for optimum polarization maintenance, lambda(PM), which is detuned from the wavelength of highest birefringence. By a suitable fiber design involving antiresonance of the core...

  9. DEFORMATION CHARACTERISTICS OF CRUSHED-STONE LAYER UNDER CYCLIC IMPACT LOADING FROM MICRO-MECHANICAL VIEW

    Science.gov (United States)

    Kono, Akiko; Matsushima, Takashi

    'Hanging sleepers', which have gaps between sleepers and ballast layer are often found in the neighborhood of rail joints or rugged surface rails. This suggests that differential settlement of the ballast layer is due to impact loading generated by the contact between running wheel and rugged surface rail. Then cyclic loading tests were performed on crushed-stone layer with two loading patterns, the one is a cyclic impact loading and the other one is cyclic 'standard' loading controlled at 1/10 loading velocity of the impact loading. It was shown that the crashed-stone layer deforms with volumetric expansion during every off-loading processes under the cyclic impact loading. This phenomena prevents crushed stone layer from forming stable grain columns, then the residual settlement under the cyclic impact loading is larger than that under the cyclic 'standard' loading. A simple mass-spring model simulates that two masses move in the opposite direction with increased frequency of harmonic excitation.

  10. pH-Responsive polymeric micelles based on amphiphilic chitosan derivatives: Effect of hydrophobic cores on oral meloxicam delivery.

    Science.gov (United States)

    Woraphatphadung, Thisirak; Sajomsang, Warayuth; Gonil, Pattarapond; Treetong, Alongkot; Akkaramongkolporn, Prasert; Ngawhirunpat, Tanasait; Opanasopit, Praneet

    2016-01-30

    The amphiphilic chitosan derivatives, N-naphthyl-N,O-succinyl chitosan (NSCS), N-octyl-N-O-succinyl chitosan (OSCS) and N-benzyl-N,O-succinyl chitosan (BSCS), were synthesized. Meloxicam (MX) was loaded into polymeric micelles (PMs), and the effects of hydrophobic moieties of the inner core segment on the loading efficiency, stability of MX-loaded PMs, cytotoxicity, drug release, and porcine small intestine permeation were investigated. Among the hydrophobic cores, the N-octyl moiety revealed the highest MX loading efficiency and most stable MX-loaded PMs compared to the other hydrophobic cores. All PMs were spherically shaped (size 213-282 nm) and had low toxicity against Caco-2 cells. The release of MX from PMs was found to be dependent on both hydrophobic cores and hydrophilic shells. In acidic medium at 0-2h, low cumulative MX release was obtained in the MX-loaded OSCS PMs compared to MX-loaded NSCS PMs and MX-loaded BSCS PMs as well as MX free drug. However, when the pH was increased to 6.8, the MX release significantly increased in all MX-loaded PMs. Furthermore, the intestinal permeation rates of MX from all MX-loaded PMs were not significantly different. These results suggest that MX was successfully incorporated into the PMs at high efficiency and good stability by optimizing the hydrophobic moieties of the inner core segments. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. A Preliminary Study on Bucket Foundations under Transient Lateral Loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo; Nielsen, Søren Kjær;

    2013-01-01

    This study aims at investigating the behaviour of monopod bucket foundations through a physical model. The foundation is installed in dense water-saturated sand and is subjected to lateral load applied at different rates. The different loading rates allow for exploring the patterns of response...... of bucket foundations in different drainage conditions. Particular focus is given to the rapid loading response of the foundation (simulating a 50 year wave or emergency stop of a wind turbine). Important knowledge on the pore pressure development within and around the foundation during loading is achieved....

  12. Impact load mitigation in sandwich beams using local resonators

    CERN Document Server

    Sharma, B

    2015-01-01

    Dynamic response of sandwich beams with resonators embedded in the cores subjected to impact loads is studied. Using finite element models the effectiveness of various local resonator frequencies under a given impact load is compared to the behavior of an equivalent mass beam. It is shown that addition of appropriately chosen local resonators into the sandwich beam is an effective method of improving its flexural bending behavior under impact loads. The effect of a given local resonance frequency under different impact load durations is also studied. It is demonstrated that the choice of appropriate local resonance frequency depends on the impact duration. Further, by performing transverse impact experiments, the finite element models are verified and the advantage of using internal resonators under impact loading conditions is demonstrated.

  13. Face/core mixed mode debond fracture toughness characterization using the modified TSD test method

    DEFF Research Database (Denmark)

    Berggreen, Christian; Quispitupa, Amilcar; Costache, Andrei;

    2014-01-01

    The modified tilted sandwich debond (TSD) test method is used to examine face/core debond fracture toughness of sandwich specimens with glass/polyester face sheets and PVC H45 and H100 foam cores over a large range of mode-mixities. The modification was achieved by reinforcing the loaded face sheet....... The fracture process was inspected visually during and after testing. For specimens with H45 core the crack propagated in the core. For specimens with an H100 core, the crack propagated between the resin-rich layer and the face sheet. © The Author(s) 2013 Reprints and permissions: sagepub...

  14. Comparison of the Structural Performance of Monolithic and Precast Reinforced Concrete Core Walls

    OpenAIRE

    Nakachi, Tadaharu

    2014-01-01

    In the core wall system in high-rise buildings, the four L-shaped core walls at the center effectively reduce seismic vibration. On the other hand, precast core walls are effective for construction because they can be built more quickly than cast-in-place core walls. In this study, a lateral loading test was conducted on a monolithic wall column simulating the corner and the area near the corner of an L-shaped core wall. The test results were compared with those of a precast wall column teste...

  15. Fault detection in reciprocating compressor valves under varying load conditions

    Science.gov (United States)

    Pichler, Kurt; Lughofer, Edwin; Pichler, Markus; Buchegger, Thomas; Klement, Erich Peter; Huschenbett, Matthias

    2016-03-01

    This paper presents a novel approach for detecting cracked or broken reciprocating compressor valves under varying load conditions. The main idea is that the time frequency representation of vibration measurement data will show typical patterns depending on the fault state. The problem is to detect these patterns reliably. For the detection task, we make a detour via the two dimensional autocorrelation. The autocorrelation emphasizes the patterns and reduces noise effects. This makes it easier to define appropriate features. After feature extraction, classification is done using logistic regression and support vector machines. The method's performance is validated by analyzing real world measurement data. The results will show a very high detection accuracy while keeping the false alarm rates at a very low level for different compressor loads, thus achieving a load-independent method. The proposed approach is, to our best knowledge, the first automated method for reciprocating compressor valve fault detection that can handle varying load conditions.

  16. Phosphorous Loading in Lake Champlain

    Science.gov (United States)

    Hoffman, H.; Halliday, B.; Lane, T.

    2016-12-01

    Phosphate movement from different sources into Lake Champlain is a problem. Excess phosphate generates algae growth causing eutrophication. This excessive growth known as algae blooms leads to poor water quality (State of Lake Report, 2015). Phosphate moves primarily by attachment to soil particles (Busman, Lamb, 09). Historically its movement has been limited to spring, summer and fall. Spring runoff is thought to contribute the most phosphate to Lake Champlain (Jensen, Tiessen, 11). With changes in global and local temperatures effecting weather patterns and the winter season, does phosphate continue to move into Lake Champlain during the winter months? Water samples from two tributaries to Lake Champlain were collected biweekly year around for the past three years. These samples were then tested for total suspended solids and phosphate levels. The results indicate that phosphate loading occurs throughout the year even during the winter months.

  17. Pattern recognition

    CERN Document Server

    Theodoridis, Sergios

    2003-01-01

    Pattern recognition is a scientific discipline that is becoming increasingly important in the age of automation and information handling and retrieval. Patter Recognition, 2e covers the entire spectrum of pattern recognition applications, from image analysis to speech recognition and communications. This book presents cutting-edge material on neural networks, - a set of linked microprocessors that can form associations and uses pattern recognition to ""learn"" -and enhances student motivation by approaching pattern recognition from the designer's point of view. A direct result of more than 10

  18. The elastic response of sandwich structures to local loading

    NARCIS (Netherlands)

    Koysin, V.; Skvortsov, Vitaly; Krahmalev, Sergey; Shipsha, Andrey

    2004-01-01

    The paper addresses the elastic response of sandwich panels to local static and dynamic loading. The bottom face is assumed to be clamped, so that the overall bending is eliminated. The governing equations are derived using the static Lamé equations for the core and the thin plate Kirchoff–Love

  19. Investigation of EAS cores

    Science.gov (United States)

    Shaulov, S. B.; Beyl, P. F.; Beysembaev, R. U.; Beysembaeva, E. A.; Bezshapov, S. P.; Borisov, A. S.; Cherdyntceva, K. V.; Chernyavsky, M. M.; Chubenko, A. P.; Dalkarov, O. D.; Denisova, V. G.; Erlykin, A. D.; Kabanova, N. V.; Kanevskaya, E. A.; Kotelnikov, K. A.; Morozov, A. E.; Mukhamedshin, R. A.; Nam, R. A.; Nesterova, N. M.; Nikolskaya, N. M.; Pavluchenko, V. P.; Piskal, V. V.; Puchkov, V. S.; Pyatovsky, S. E.; Ryabov, V. A.; Sadykov, T. Kh.; Schepetov, A. L.; Smirnova, M. D.; Stepanov, A. V.; Uryson, A. V.; Vavilov, Yu. N.; Vildanov, N. G.; Vildanova, L. I.; Zayarnaya, I. S.; Zhanceitova, J. K.; Zhukov, V. V.

    2017-06-01

    The development of nuclear-electromagnetic cascade models in air in the late forties have shown informational content of the study of cores of extensive air showers (EAS). These investigations were the main goal in different experiments which were carried out over many years by a variety of methods. Outcomes of such investigations obtained in the HADRON experiment using an X-ray emulsion chamber (XREC) as a core detector are considered. The Ne spectrum of EAS associated with γ-ray families, spectra of γ-rays (hadrons) in EAS cores and the Ne dependence of the muon number, ⟨Nμ⟩, in EAS with γ-ray families are obtained for the first time at energies of 1015-1017 eV with this method. A number of new effects were observed, namely, an abnormal scaling violation in hadron spectra which are fundamentally different from model predictions, an excess of muon number in EAS associated with γ-ray families, and the penetrating component in EAS cores. It is supposed that the abnormal behavior of γ-ray spectra and Ne dependence of the muon number are explained by the emergence of a penetrating component in the 1st PCR spectrum `knee' range. Nuclear and astrophysical explanations of the origin of the penetrating component are discussed. The necessity of considering the contribution of a single close cosmic-ray source to explain the PCR spectrum in the knee range is noted.

  20. Some Core Contested Concepts

    Science.gov (United States)

    Chomsky, Noam

    2015-01-01

    Core concepts of language are highly contested. In some cases this is legitimate: real empirical and conceptual issues arise. In other cases, it seems that controversies are based on misunderstanding. A number of crucial cases are reviewed, and an approach to language is outlined that appears to have strong conceptual and empirical motivation, and…