WorldWideScience

Sample records for core evaluation form

  1. Formed Core Sampler Hydraulic Conductivity Testing

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D. H.; Reigel, M. M.

    2012-09-25

    A full-scale formed core sampler was designed and functionally tested for use in the Saltstone Disposal Facility (SDF). Savannah River National Laboratory (SRNL) was requested to compare properties of the formed core samples and core drilled samples taken from adjacent areas in the full-scale sampler. While several physical properties were evaluated, the primary property of interest was hydraulic conductivity. Differences in hydraulic conductivity between the samples from the formed core sampler and those representing the bulk material were noted with respect to the initial handling and storage of the samples. Due to testing conditions, the site port samples were exposed to uncontrolled temperature and humidity conditions prior to testing whereas the formed core samples were kept in sealed containers with minimal exposure to an uncontrolled environment prior to testing. Based on the results of the testing, no significant differences in porosity or density were found between the formed core samples and those representing the bulk material in the test stand.

  2. Classifying Star Forming Cores through Chemical Anomalies

    Science.gov (United States)

    Hoq, Sadia; Jackson, J.; Foster, J.

    2011-05-01

    The chemical makeup of Infrared Dark Clouds may offer a method to classify star forming cores. This study uses the molecular line maps from the Millimetre Astronomy Legacy Team 90 GHz (MALT90) Survey, observed using the 22-m ATNF Mopra Telescope. The relative abundances of the four molecules, N2H+, HNC, HCN and HCO+ are calculated for each of 500 cores to determine the chemical signatures of star forming cores in their early evolutionary stages, as deduced from Spitzer data. Cores are classified as prestellar, protostellar, or HII regions. Initial findings indicate that sources with relatively strong N2H+ lines are prestellar, whereas weak N2H+ lines may designate protostellar or HII regions. These chemical anomalies, where the N2H+ lines are either very prominent or weak are rare, suggesting that these are short-lived chemical phases.

  3. A factor analytic study of the Italian National Institute of Health Quality of Life – Core Evaluation Form (ISSQoL-CEF

    Directory of Open Access Journals (Sweden)

    M Lauriola

    2010-03-01

    Full Text Available M Lauriola1, R Murri3, M Massella4, M Mirra4, S Donnini4, V Fragola4, J Ivanovic5, M Pavoni6, G Mancini2, R Bucciardini41Department of Social and Developmental Psychology, 2Department of Infectious and Tropical Diseases, University of Rome “La Sapienza”, Rome, Italy; 3Catholic University of “Sacro Cuore”, Rome, Italy; 4Istituto Superiore di Sanità, Rome, Italy; 5National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy; 6Ospedale Civile Santa Maria delle Croci, Ravenna, ItalyObjectives: The Italian National Institute of Health Quality of Life – Core Evaluation Form (ISSQoL-CEF is a specific questionnaire measuring health-related quality of life for human immunodeficiency virus-infected people in the era of highly active antiretroviral therapy. The main goal of this study was to examine the construct validity of this questionnaire by confirmation of its hypothesized dimensional structure.Methods: Baseline quality of life data from four clinical studies were collected and a confirmatory factor analysis of the ISSQoL-CEF items was carried out. Both first-order and secondorder factor models were tested: Model 1 with nine correlated first-order factors; Model 2 with three correlated second-order factors (Physical, Mental, and Social Health; Model 3 with two correlated second-order factors (Physical and Mental/Social Health; Model 4 with only one second-order factor (General Health.Results: A total of 261 patients were surveyed. Model 1 had a good fit to the data. Model 2 had an acceptable fit to the data and it was the best of all hierarchical models. However, Model 2 fitted the data worse than Model 1.Conclusions: The findings of in this study, consistent with the results of previous study, pointed out the construct validity of the ISSQoL-CEF.Keywords: confirmatory factor analysis, HRQoL, patient-reported outcomes

  4. [PIC Program Evaluation Forms.

    Science.gov (United States)

    Short, N. J.

    These 4 questionnaires are designed to elicit teacher and parent evaluations of the Prescriptive Instruction Center (PIC) program. Included are Teacher Evaluation of Program Effectiveness (14 items), M & M Evaluation of Program Implementation (methods and materials specialists; 11 items), Teacher Evaluation of Program Effectiveness--Case Study…

  5. Elastic constants for superplastically formed/diffusion-bonded corrugated sandwich core

    Science.gov (United States)

    Ko, W. L.

    1980-01-01

    Formulas and associated graphs for evaluating the effective elastic constants for a superplastically formed/diffusion bonded (SPF/DB) corrugated sandwich core, are presented. A comparison of structural stiffnesses of the sandwich core and a honeycomb core under conditions of equal sandwich core density was made. The stiffness in the thickness direction of the optimum SPF/DB corrugated core (that is, triangular truss core) is lower than that of the honeycomb core, and that the former has higher transverse shear stiffness than the latter.

  6. Discerning the Form of the Dense Core Mass Function

    CERN Document Server

    Swift, Jonathan J

    2009-01-01

    We investigate the ability to discern between lognormal and powerlaw forms for the observed mass function of dense cores in star forming regions. After testing our fitting, goodness-of-fit, and model selection procedures on simulated data, we apply our analysis to 14 datasets from the literature. Whether the core mass function has a powerlaw tail or whether it follows a pure lognormal form cannot be distinguished from current data. From our simulations it is estimated that datasets from uniform surveys containing more than approximately 500 cores with a completeness limit below the peak of the mass distribution are needed to definitively discern between these two functional forms. We also conclude that the width of the core mass function may be more reliably estimated than the powerlaw index of the high mass tail and that the width may also be a more useful parameter in comparing with the stellar initial mass function to deduce the statistical evolution of dense cores into stars.

  7. Evaluation of Fugen core management code (POLESTAR)

    Energy Technology Data Exchange (ETDEWEB)

    Shiratori, Yoshitake (Power Reactor and Nuclear Fuel Development Corp., Tsuruga, Fukui (Japan). Fugen Nuclear Power Station); Matsumoto, Mitsuo; Deshimaru, Takehide; Saito, Kuniyoshi

    1991-06-01

    Core management code POLESTAR has been developed by PNC and it has enough functions for core management. The code has been successfully used to carry out core management of Fugen such as making a long term or next cycle fuel loading plan, predicting detailed characteristics of a next cycle core, planning of a control rod pattern and evaluating the core life time after reactor start-up and so on. This code has been contributed to the reliable and economical operation of Fugen, since its accuracy has been checked and the code has been tailored by comparing its calculation results with various measured data. (author).

  8. Evaluation of a barley core collection for spot form net blotch reaction reveals distinct genotype specific pathogen virulence and host susceptibility

    Science.gov (United States)

    Spot form net blotch (SFNB) caused by Pyrenophora teres Drechs. f. maculata Smedeg., (anamorph Drechslera teres [Sacc.] Shoem.) is a major foliar disease of barley (Hordeum vulgare L.) worldwide. SFNB epidemics have recently been observed in major barley producing countries, suggesting that the loca...

  9. The DLESE Evaluation Core Services Project

    Science.gov (United States)

    Buhr, S. M.; Barker, L. J.; Reeves, T. C.

    2003-12-01

    The DLESE Evaluation Core Service project will conduct evaluation of DLESE and provide evaluation consultation, resources and services to the DLESE community. Through this work we anticipate that we will learn more about the impact and use of digital libraries, and will promote an evaluation mindset within the geoscience education community. Activities of the DLESE Evaluation Service team include 1) evaluation planning for and of DLESE, 2) conducting formative evaluation of DLESE (user needs, data access, collections, outreach), 3) conducting classroom evaluation of DLESE use on teaching practices and learning outcomes, and 4) collection, synthesis, and reporting of evaluation findings garnered from all core teams and major projects. Many opportunities for community involvement exist. A strand group convened during the 2004 DLESE Annual Meeting took DLESE Evaluation as their topic, provided recommendations and will continue their activities through the year. The related Evaluation Toolkit collection is now discoverable through DLESE, and upcoming activities of all the core teams will provide evaluation opportunities to be described. Other community opportunities include consulting with Evaluation Service for education grant proposals, attending an evaluation workshop,and applying for an Evaluation Minigrant (up to \\$5K per award) Progress to date will be discussed, the Evaluation Core Services team members will be introduced, and plans and opportunities will be described in more detail.

  10. Sodium fast reactor evaluation: Core materials

    Science.gov (United States)

    Cheon, Jin Sik; Lee, Chan Bock; Lee, Byoung Oon; Raison, J. P.; Mizuno, T.; Delage, F.; Carmack, J.

    2009-07-01

    In the framework of the Generation IV Sodium Fast Reactor (SFR) Program the Advanced Fuel Project has conducted an evaluation of the available fuel systems supporting future sodium cooled fast reactors. In this paper the status of available and developmental materials for SFR core cladding and duct applications is reviewed. To satisfy the Generation IV SFR fuel requirements, an advanced cladding needs to be developed. The candidate cladding materials are austenitic steels, ferritic/martensitic (F/M) steels, and oxide dispersion strengthened (ODS) steels. A large amount of irradiation testing is required, and the compatibility of cladding with TRU-loaded fuel at high temperatures and high burnup must be investigated. The more promising F/M steels (compared to HT9) might be able to meet the dose requirements of over 200 dpa for ducts in the GEN-IV SFR systems.

  11. CoreDevRec:Automatic Core Member Recommendation for Contribution Evaluation

    Institute of Scientific and Technical Information of China (English)

    蒋竞; 贺佳欢; 陈学渊

    2015-01-01

    The pull-based software development helps developers make contributions flexibly and effciently. Core members evaluate code changes submitted by contributors, and decide whether to merge these code changes into repositories or not. Ideally, code changes are assigned to core members and evaluated within a short time after their submission. However, in reality, some popular projects receive many pull requests, and core members have di昋culties in choosing pull requests which are to be evaluated. Therefore, there is a growing need for automatic core member recommendation, which improves the evaluation process. In this paper, we investigate pull requests with manual assignment. Results show that 3.2%∼40.6% of pull requests are manually assigned to specific core members. To assist with the manual assignment, we propose CoreDevRec to recommend core members for contribution evaluation in GitHub. CoreDevRec uses support vector machines to analyze different kinds of features, including file paths of modified codes, relationships between contributors and core members, and activeness of core members. We evaluate CoreDevRec on 18 651 pull requests of five popular projects in GitHub. Results show that CoreDevRec achieves accuracy from 72.9% to 93.5% for top 3 recommendation. In comparison with a baseline approach, CoreDevRec improves the accuracy from 18.7% to 81.3% for top 3 recommendation. Moreover, CoreDevRec even has higher accuracy than manual assignment in the project TrinityCore. We believe that CoreDevRec can improve the assignment of pull requests.

  12. Discrete stages of core formation survive the Moon-forming impact

    Science.gov (United States)

    Jackson, C.; Bennett, N.; Du, Z.; Fei, Y.

    2016-12-01

    There is mounting evidence that Earth contains isotopic variations produced by short-lived systems, namely Hf-W and I-Xe. The lifetimes of these systems are 50 Ma and 80 Ma, respectively, requiring that chemical heterogeneities that were formed extremely early in solar system history and have survived within Earth's mantle to the modern day. The isotopic heterogeneity observed within Earth's mantle contrasts the isotopic similarity of bulk silicate Earth and bulk silicate Moon. This suggests the process(es) responsible for the isotopic variations within Earth predate the Moon-forming impact. Here, we focus on the potential role of core-formation in generating coupled isotopic variations associated with the Hf-W and I-Xe systems. We present metal-silicate partitioning data for W and I from experiments employing laser-heated diamond anvil cells. Experiments were conducted up to the pressure and temperature conditions directly relevant to core formation at GSECARS, APS. Samples were prepared using focused ion beam milling and analyzed by field emission electron microbeam techniques (EDS & WDS). These analyses demonstrate that W and I preferentially partition into the core under a wide range of conditions. In combination with literature data, this suggests that core formation left the residual mantle with an increased Hf/W ratio and a decreased I/Xe ratio. These parent-daughter fractionations lead to radiogenic W and unradiogenic Xe isotopic signatures compared to mantle that experienced the extraction of core material at a later date, on average. Relatively radiogenic W and unradiogenic Xe isotopic signatures are associated with plume rocks, potentially linking the plume source to mantle reservoirs that experienced early core extraction relative to the bulk mantle. Compositional variables, pressure, and temperature also affect the magnitude of Hf/W and I/Xe fractionation associated with core formation. The interplay of these variables will be evaluated alongside the

  13. Experience in forming and core mixtures by Alphaset technology

    OpenAIRE

    I. Vasková; Smolková, M.; J. Malik; Š. Eperješi

    2008-01-01

    Chemically bound mixtures have had the evolution effect upon the economical and quality aspects of the foundry operations since they presentation at the market. The higher output and significantly increased production efficiency of moulds and cores has lead to the material increase in the quality and profit of the foundries. It can be seen that in last several years the knowledge of bounds based on the organic resins has made enormous advances. The higher strength, improved properties under e...

  14. Experience in forming and core mixtures by Alphaset technology

    OpenAIRE

    I. Vasková; M. Smolková; J. Malik; Eperješi Š.

    2008-01-01

    Chemically bound mixtures have had the evolution effect upon the economical and quality aspects of the foundry operations since they presentation at the market. The higher output and significantly increased production efficiency of moulds and cores has lead to the material increase in the quality and profit of the foundries. It can be seen that in last several years the knowledge of bounds based on the organic resins has made enormous advances. The higher strength, improved properties under e...

  15. Experience in forming and core mixtures by Alphaset technology

    Directory of Open Access Journals (Sweden)

    I. Vasková

    2008-07-01

    Full Text Available Chemically bound mixtures have had the evolution effect upon the economical and quality aspects of the foundry operations since they presentation at the market. The higher output and significantly increased production efficiency of moulds and cores has lead to the material increase in the quality and profit of the foundries. It can be seen that in last several years the knowledge of bounds based on the organic resins has made enormous advances. The higher strength, improved properties under elevated temperatures, the reduction of the environmental impacts of the organic bounds and at the same their highly improved regenerationability ensure that these systems will be still more significant binding system. The organic binding systems are predominantly being developed recemtly. The technology AlpHaset is ranked among the alkali binding systems. This technology has certain disadvantages – lower strength, speed of hardening- which have been gradually eliminated.

  16. Mobile based optical form evaluation system

    Directory of Open Access Journals (Sweden)

    Asım Sinan YÜKSEL

    2016-05-01

    Full Text Available Optical forms that contain multiple-choice answers are widely used both for electing students and evaluating student achievements in education systems in our country and worldwide. Optical forms are evaluated by employing optical mark recognition techniques through optical readers. High cost of these machines, limited access to them, long waiting time for evaluation results make the process hard for educationists working in cities or countries. In this study, a mobile application was developed for the educationists who own mobile phones or tablets for the purpose of evaluating students' answer sheets quickly and independent of location and optical readers. Optical form recognition, reading and evaluation processes are done on the image of student's answer sheet that is taken with the mobile phone or tablet of educationist. The Android based mobile application that we developed has a user-friendly interface, high success rate and is the first of our knowledge application that operates on mobile platforms in this field.

  17. Evaluating Community Health Advisor (CHA) Core Competencies: The CHA Core Competency Retrospective Pretest/Posttest (CCCRP).

    Science.gov (United States)

    Story, Lachel; To, Yen M

    2016-05-01

    Health care and academic systems are increasingly collaborating with community health advisors (CHAs) to provide culturally relevant health interventions that promote sustained community transformation. Little attention has been placed on CHA training evaluation, including core competency attainment. This study identified common CHA core competencies, generated a theoretically based measure of those competencies, and explored psychometric properties of that measure. A concept synthesis revealed five CHA core competencies (leadership, translation, guidance, advocacy, and caring). The CHA Core Competency Retrospective Pretest/Posttest (CCCRP) resulted from that synthesis, which was administered using multiple approaches to individuals who previously received CHA training (N= 142). Exploratory factor analyses revealed a two-factor structure underlying the posttraining data, and Cronbach's alpha indicated high internal consistency. This study suggested some CHA core competencies might be more interrelated than previously thought, and two major competencies exist rather than five and supported the CCCRP's use to evaluate core competency attainment resulting from training.

  18. Gravitational wave signatures in black-hole forming core collapse

    CERN Document Server

    Cerdá-Durán, Pablo; Aloy, Miguel A; Font, José A; Obergaulinger, Martin

    2013-01-01

    We present numerical simulations in general relativity of collapsing stellar cores. Our initial model consists of a low metallicity rapidly-rotating progenitor which is evolved in axisymmetry with the latest version of our general relativistic code CoCoNuT, which allows for black hole formation and includes the effects of a microphysical equation of state (LS220) and a neutrino leakage scheme to account for radiative losses. The motivation of our study is to analyze in detail the emission of gravitational waves in the collapsar scenario of long gamma-ray bursts. Our simulations show that the phase during which the proto-neutron star (PNS) survives before ultimately collapsing to a black hole is particularly optimal for gravitational wave emission. The high-amplitude waves last for several seconds and show a remarkable quasi-periodicity associated with the violent PNS dynamics, namely during the episodes of convection and the subsequent nonlinear development of the standing-accretion shock instability (SASI). ...

  19. GRAVITATIONAL WAVE SIGNATURES IN BLACK HOLE FORMING CORE COLLAPSE

    Energy Technology Data Exchange (ETDEWEB)

    Cerdá-Durán, Pablo; DeBrye, Nicolas; Aloy, Miguel A.; Font, José A.; Obergaulinger, Martin, E-mail: pablo.cerda@uv.es [Departamento de Astronomia y Astrofísica, Universidad de Valencia, c/Dr. Moliner 50, E-46100-Burjassot (Spain)

    2013-12-20

    We present general relativistic numerical simulations of collapsing stellar cores. Our initial model consists of a low metallicity rapidly-rotating progenitor which is evolved in axisymmetry with the latest version of our general relativistic code CoCoNuT, which allows for black hole formation and includes the effects of a microphysical equation of state (LS220) and a neutrino leakage scheme to account for radiative losses. The motivation of our study is to analyze in detail the emission of gravitational waves in the collapsar scenario of long gamma-ray bursts. Our simulations show that the phase during which the proto-neutron star (PNS) survives before ultimately collapsing to a black hole is particularly optimal for gravitational wave emission. The high-amplitude waves last for several seconds and show a remarkable quasi-periodicity associated with the violent PNS dynamics, namely during the episodes of convection and the subsequent nonlinear development of the standing-accretion shock instability (SASI). By analyzing the spectrogram of our simulations we are able to identify the frequencies associated with the presence of g-modes and with the SASI motions at the PNS surface. We note that the gravitational waves emitted reach large enough amplitudes to be detected with third-generation detectors such as the Einstein Telescope within a Virgo Cluster volume at rates ≲ 0.1 yr{sup –1}.

  20. Chemical Tracers of Pre-Brown Dwarf Cores Formed Through Turbulent Fragmentation

    CERN Document Server

    Holdship, Jonathan

    2015-01-01

    A gas-grain time dependent chemical code, UCL\\_CHEM, has been used to investigate the possibility of using chemical tracers to differentiate between the possible formation mechanisms of brown dwarfs. In this work, we model the formation of a pre-brown dwarf core through turbulent fragmentation by following the depth-dependent chemistry in a molecular cloud through the step change in density associated with an isothermal shock and the subsequent freefall collapse once a bound core is produced. Trends in the fractional abundance of molecules commonly observed in star forming cores are then explored to find a diagnostic for identifying brown dwarf mass cores formed through turbulence. We find that the cores produced by our models would be bright in CO and NH$_3$ but not in HCO$^+$. This differentiates them from models using purely freefall collapse as such models produce cores that would have detectable transitions from all three molecules.

  1. Did Jupiter's core form in the innermost parts of the Sun's protoplanetary disk?

    CERN Document Server

    Raymond, Sean N; Bitsch, Bertram; Jacobson, Seth A

    2016-01-01

    Jupiter's core is generally assumed to have formed beyond the snow line. Here we consider an alternative scenario, that Jupiter's core may have accumulated in the innermost parts of the protoplanetary disk. A growing body of research suggests that small particles ("pebbles") continually drift inward through the disk. If a fraction of drifting pebbles is trapped at the inner edge of the disk a several Earth-mass core can quickly grow. Subsequently, the core may migrate outward beyond the snow line via planet-disk interactions. Of course, to reach the outer Solar System Jupiter's core must traverse the terrestrial planet-forming region. We use N-body simulations including synthetic forces from an underlying gaseous disk to study how the outward migration of Jupiter's core sculpts the terrestrial zone. If the outward migration is fast (Tmig~10^4 years), the core simply migrates past resident planetesimals and planetary embryos. However, if its migration is slower (Tmig~10^5 years) the core removes solids from th...

  2. Properties of dense cores in clustered massive star-forming regions at high angular resolution

    CERN Document Server

    Sanchez-Monge, Alvaro; Fontani, Francesco; Busquet, Gemma; Juarez, Carmen; Estalella, Robert; Tan, Jonathan C; Sepulveda, Inma; Ho, Paul T P; Zhang, Qizhou; Kurtz, Stan

    2013-01-01

    We aim at characterising dense cores in the clustered environments associated with massive star-forming regions. For this, we present an uniform analysis of VLA NH3(1,1) and (2,2) observations towards a sample of 15 massive star-forming regions, where we identify a total of 73 cores, classify them as protostellar, quiescent starless, or perturbed starless, and derive some physical properties. The average sizes and ammonia column densities are 0.06 pc and 10^15 cm^-2, respectively, with no significant differences between the starless and protostellar cores, while the linewidth and rotational temperature of quiescent starless cores are smaller, 1.0 km/s and 16 K, than those of protostellar (1.8 km/s, 21 K), and perturbed starless (1.4 km/s, 19 K) cores. Such linewidths and temperatures for these quiescent starless cores in the surroundings of massive stars are still significantly larger than the typical values measured in starless cores of low-mass star-forming regions, implying an important non-thermal compone...

  3. Thermal, dynamic and compositional aspects of the core-forming Earth

    Science.gov (United States)

    Stevenson, D. J.

    1985-01-01

    Core formation is the most important and singular differentiation event in the history of a terrestrial planet. It almost certainly involved the downward migration of a partially or wholly molten iron alloy through a silicate and oxide mantle, and was contemporaneous with accretion. Several important, unresolved issues which have implications for mantle and core geochemistry, the thermal history of the Earth, and the origin of geomagnetism are addressed: whether the early Earth was molten; whether core formation involved low or high pressure geochemistry, or both; early Earth mantle homogenization; whether equilibration established between core forming material and the mantle through which it migrated; and how much iron is stranded and unable to reach the core.

  4. The growth of Ho:YAG single crystals by Czochralski method and investigating the formed cores

    Energy Technology Data Exchange (ETDEWEB)

    Hasani Barbaran, J., E-mail: jhasani@aeoi.org.ir; Ghani Aragi, M. R.; Javaheri, I.; Baharvand, B.; Tabasi, M.; Layegh Ahan, R.; Jangjo, E. [NSTRI, Laser and Optics Research School (Iran, Islamic Republic of)

    2015-12-15

    Ho:YAG single crystals were grown by Czochralski technique, and investigated by the X-ray diffraction (XRD) and optical methods. The crystals were cut and polished in order to observe and analyze their cores. It was found that the deviation of the cores formed in the Czochralski grown Ho:YAG single crystals are resulted from non-symmetrical status of thermal insulation around the Iridium crucible.

  5. Evaluation of Treatments to Reduce Hardness of Agave americana Core

    OpenAIRE

    Ramírez, José A.; Gómez-Ayala, Rocio C.; Cuauhtémoc Jacques-Hernández; Manuel Vázquez

    2006-01-01

    Agave americana contains inulin as storage carbohydrate. Therefore, agave is interesting to be used for the extraction of inulin by pressing. The yield of the process is low due to the high hardness of the core. The objective of this work was to evaluate pretreatments to reduce the hardness in the process of obtaining inulin by pressing. Treatments with water, sulphuric acid 1 % (by mass) or sodium hydroxide 1 % (by mass) were tested and optimized. The pretreatment of the core of A. americana...

  6. Sol-gel processing to form doped sol-gel monoliths inside hollow core optical fiber and sol-gel core fiber devices made thereby

    Science.gov (United States)

    Shaw, Harry C. (Inventor); Ott, Melanie N. (Inventor); Manuel, Michele V. (Inventor)

    2002-01-01

    A process of fabricating a fiber device includes providing a hollow core fiber, and forming a sol-gel material inside the hollow core fiber. The hollow core fiber is preferably an optical fiber, and the sol-gel material is doped with a dopant. Devices made in this manner includes a wide variety of sensors.

  7. A Formative Program Evaluation of Electronic Clinical Tracking System Documentation to Meet National Core Competencies.

    Science.gov (United States)

    Smith, Lynette S; Branstetter, M Laurie

    2016-09-01

    Electronic clinical tracking systems are used in many educational institutions of higher learning to document advanced practice registered nursing students' clinical experiences. Students' clinical experiences are constructed according to the National Organization of Nurse Practitioner Faculties core competencies. These competencies form a basis for evaluation of advanced practice registered nursing programs. However, no previous studies have evaluated the use of electronic clinical tracking systems to validate students' clinical experiences in meeting national core competencies. Medatrax, an electronic clinical tracking system, is evaluated using a formative program evaluation approach to determine if students' clinical documentations meet Family/Across the Lifespan Nurse Practitioner Competencies in a midsouthern family nurse practitioner program. This formative program evaluation supports the use of an electronic clinical tracking system in facilitating accreditation and program outcome goals. The significance of this study is that it provides novel evidence to support the use of an electronic clinical tracking system to assist a midsouthern school of nursing in meeting national core competencies.

  8. Spitzer and Magellan Observations of NGC 2264: A Remarkable Star Forming Core Near IRS-2

    CERN Document Server

    Young, E T; Lada, C J; Mainzer, A K; Marengo, M; Murphy, D C; Muzerolle, J; Persson, S E; Siegler, N; Teixeira, P S

    2006-01-01

    We analyze {\\it Spitzer} and Magellan observations of a star forming core near IRS-2 in the young cluster NGC 2264. The submillimeter source IRAS 12 S1, previously believed to be an intermediate mass Class 0 object is shown to be a dense collection of embedded, low mass stars. We argue that this group of stars represents the fragmenting collapse of a dense, turbulent core, based on a number of indicators of extreme youth. With reasonable estimates for the velocity dispersion in the group, we estimate a dynamical lifetime of only a few x 10$^{4}$ years. Spectral energy distributions of stars in the core are consistent with Class I or Class 0 assignments. We present observations of an extensive system of molecular hydrogen emission knots. The luminosity of the objects in the core region are consistent with roughly solar mass protostars.

  9. Evaluation of Treatments to Reduce Hardness of Agave americana Core

    Directory of Open Access Journals (Sweden)

    José A. Ramírez

    2006-01-01

    Full Text Available Agave americana contains inulin as storage carbohydrate. Therefore, agave is interesting to be used for the extraction of inulin by pressing. The yield of the process is low due to the high hardness of the core. The objective of this work was to evaluate pretreatments to reduce the hardness in the process of obtaining inulin by pressing. Treatments with water, sulphuric acid 1 % (by mass or sodium hydroxide 1 % (by mass were tested and optimized. The pretreatment of the core of A. americana with sulphuric acid 1 % allowed the reduction of hardness from 30 000 g to 2000 g of breaking force. The mathematical model obtained predicts an optimum processing at 84 °C during 75 min. The treatment with sulphuric acid 1 % also allows white core of A. americana to be obtained, while the other treatments provide yellow core. These results open a good alternative to obtain value added products from this resource.

  10. Core Self-Evaluations, life satisfaction, and sport satisfaction

    OpenAIRE

    Antón Aluja

    2014-01-01

    We investigated the association between Core Self-Evaluations (CSE) and life and sport satisfaction to assess whether the Core Self-Evaluations scale was a better predictor of life satisfaction or sport satisfaction. The study included three hundred and thirteen athletes (231 men and 82 women; age range to 47 years (Mage=22.9 years, SDage=5.9 years)). Participants completed the French language version of the CSE scale, the Satisfaction with Life Scale, and the Satisfaction with Sport Scale. A...

  11. Analysis of phosphorus forms in sediment cores from ephemeral ponds on Ardley Island, West Antarctica

    Institute of Scientific and Technical Information of China (English)

    YANG Lianjiao; QIN Xianyan; SUN Liguang; HUANG Tao; WANG Yuhong

    2015-01-01

    The guano of penguins, other seabirds, and pinnipeds is an important source of phosphorus in the ecosystems of Antarctica. To study the vertical distribution of phosphorus in sediments influenced by penguins, we measured phosphorus forms in two sediment cores (G1 and Q2) from ephemeral ponds on Ardley Island. We also investigated the correlations between these phosphorus forms and physicochemical characteristics. Inorganic phosphorus was the main form of phosphorus in both cores. The vertical distribution patterns of phosphorus forms in G1 and Q2 differed, indicating different sedimentary sources. The G1 sediment profile was more influenced by penguin guano than the Q2 profile, and as a result sediments in the G1 core had higher total phosphorus, non-apatite inorganic phosphorus, and apatite phosphorus content. The findings from two ephemeral ponds on Ardley Island indicate that the contribution of penguin guano to organic matter in G1 core has increased in recent times, while Q2 showed a relatively larger contribution from mosses in ancient times, evident from the lithology and the vertical trend in organic matter.

  12. Raising the Reliability of Forming Rolls by Alloying Their Core with Copper

    Science.gov (United States)

    Zhizhkina, N. A.

    2016-11-01

    The mechanical properties and the structure of forming rolls from cast irons of different compositions are studied. A novel iron including a copper additive that lowers its chilling and raises the homogeneity of the structure is suggested for the roll cores. The use of such iron should raise the reliability of the rolls in operation.

  13. Relationship of core self-evaluations to goal setting, motivation, and performance.

    Science.gov (United States)

    Erez, A; Judge, T A

    2001-12-01

    A newly developed personality taxonomy suggests that self-esteem, locus of control, generalized self-efficacy, and neuroticism form a broad personality trait termed core self-evaluations. The authors hypothesized that this broad trait is related to motivation and performance. To test this hypothesis, 3 studies were conducted. Study 1 showed that the 4 dispositions loaded on 1 higher order factor. Study 2 demonstrated that the higher order trait was related to task motivation and performance in a laboratory setting. Study 3 showed that the core trait was related to task activity, productivity as measured by sales volume, and the rated performance of insurance agents. Results also revealed that the core self-evaluations trait was related to goal-setting behavior. In addition, when the 4 core traits were investigated as 1 nomological network, they proved to be more consistent predictors of job behaviors than when used in isolation.

  14. Evaluation of Core Vocabulary Therapy for Deaf Children: Four Treatment Case Studies

    Science.gov (United States)

    Herman, Rosalind; Ford, Katie; Thomas, Jane; Oyebade, Natalie; Bennett, Danita; Dodd, Barbara

    2015-01-01

    This study evaluated whether core vocabulary intervention (CVT) improved single word speech accuracy, consistency and intelligibility in four 9-11-year-old children with profound sensori-neural deafness fitted with cochlear implants and/or digital hearing aids. Their speech was characterized by inconsistent production of different error forms for…

  15. Dosimetry Evaluation of In-Core and Above-Core Zirconium Alloy Samples in a PWR

    Directory of Open Access Journals (Sweden)

    Amiri Benjamin W.

    2016-01-01

    Full Text Available A description of the neutron fluence analysis of activated zirconium alloys samples at a Westinghouse 3-loop reactor is presented. These samples were irradiated in the core and in the fuel plenum region, where dosimetry measurements are relatively rare compared with regions radially outward of the core. Dosimetry measurements performed by Batelle/PNNL are compared to the calculational models. Good agreement is shown with the in-core measurements when using analysis conditions expected to best represent this region, such as an assembly-specific axial power distribution. However, the use of these conditions to evaluate dosimetry in the fuel plenum region can lead to significant underestimation of the fluence. The use of a flat axial power distribution, however, does not underestimate the fluence in the fuel plenum region.

  16. Evaluation of control strategies in forming processes

    Directory of Open Access Journals (Sweden)

    Calmano Stefan

    2015-01-01

    Full Text Available Products of forming processes are subject to quality fluctuations due to uncertainty in semi-finished part properties as well as process conditions and environment. An approach to cope with these uncertainties is the implementation of a closed-loop control taking into account the actual product properties measured by sensors or estimated by a mathematical process model. Both methods of uncertainty control trade off with a financial effort. In case of sensor integration the effort is the cost of the sensor including signal processing as well as the design and manufacturing effort for integration. In case of an estimation model the effort is mainly determined by the time and knowledge needed to derive the model, identify the parameters and implement the model into the PLC. The risk of mismatch between model and reality as well as the risk of wrong parameter identification can be assumed as additional uncertainty (model uncertainty. This paper evaluates controlled and additional uncertainty by taking into account process boundary conditions like the degree of fluctuations in semi-finished part properties. The proposed evaluation is demonstrated by the analysis of exemplary processes.

  17. Nitrogen forms and decomposition of organic carbon in the southern Bohai Sea core sediments

    Institute of Scientific and Technical Information of China (English)

    宋金明; 马红波; 吕晓霞

    2002-01-01

    Study on form characteristics of nitrogen in marine sediments is the primary method to research its biogeochemical cycling and nitrogen form characteristics in core sediments can reflect the process and results of early diagenesis in a certain degree. In this paper, Sequential extraction process in natural grain size was used for studying the existent forms of nitrogen in five core sediments of the southern Bohai Sea for the first time. Nitrogen was divided into two parts - transferable and fixed based on whether it could be extracted by the reagent. Distributions and early diagenesis of transferable nitrogen forms in the southern Bohai Sea were researched integratedly. Results indicate that IEF- N and OSFN are predominant forms in transferable part in the studied core sediments. Contents of different nitrogen forms vary differently with depth, and have different diagenesis process. Decomposition constant of organic nitrogen (ON) and OC are about 15.51 × 10-3a-1and 4.79 × 10-3a-1 respectively, and the decomposition content of biogenic elements C, N, P, Si has the sequence N>P>C>Si. OC/TN (simplified as C/N in the following) ratio is much lower than OC/ON, which indicates that sediment preserves plenty of inorganic nitrogen (IN) and/or fixed nitrogen, and the decrease of OC/ON ratio with depth is due to ON reservation in sediments. Generally, transferable nitrogen accounts for more proportion of TN in the surface layer than in the deep layer of core sediments, whereas, some stable forms of nitrogen can activate and become transferable under appropriate environment, which induces the proportion of transferable nitrogen in TN in the deep layer to be almost the same as that in the surface layer.

  18. From antiferroelectricity to ferroelectricity in smectic mesophases formed by bent-core molecules

    Indian Academy of Sciences (India)

    Carsten Tschierske; Gert Dantlgraber

    2003-08-01

    This contribution gives an overview of ferroelectric switching liquid crystalline phases formed by bent-core molecules. First a description of some general principles behind the mesophase formation within bent-core systems will be given, followed by a short review of the mesophase structures formed by such molecules. Then, different classes of ferroelectric switching bent-core mesogens will be described. This type of switching behaviour has been reported for several subtypes of polar smectic phases (B2, B5, B7 and SmCG) and recently for columnar mesophases. In this discussion particular attention will be made to polyphilic bent-core molecules, composed of three incompatible units, a bent aromatic core, alkyl chains and an oligosiloxane unit. The importance of the decoupling of the layers into microsegregated sublayers for the ferroelectric organisation is discussed. Many of the ferroelectric switching mesophases show dark textures with distinct regions of opposite chirality in their ground states. It is discussed that this might be due to a helical superstructure formed as a result of an escape from macroscopic polar order. Hence, the materials themselves are not ferroelectric in the ground state, but upon alignment within an electric field in the measuring cells the ferroelectric states are stabilised by surface interactions, leading to a ferroelectric switching system. The designing principle was extended to mesogenic dimers with bent-core structural units. For these compounds, depending on the number of dimethylsiloxane units in the spacer either ferroelectric or antiferroelectric switching was observed, whereby the effect of parity is reversed to that observed for conventional calamitic dimesogens. Finally, a carbosilane-based first generation dendrimer is reported. It shows a ferroelectric switching phase, for which a non-correlated organisation of tilted polar smectic layers is proposed (SmCPR).

  19. Core Self-Evaluation and Goal Orientation: Understanding Work Stress

    Science.gov (United States)

    Morris, Michael Lane; Messal, Carrie B.; Meriac, John P.

    2013-01-01

    This study investigates the dispositional factors related to work stress. Specifically, previous research has demonstrated a relationship between core self-evaluation (CSE) and general life stress. This article extends past research by examining the relationship between CSE and work stress, and includes goal orientation as a potential mediator of…

  20. Longitudinal Relationships between Core Self-Evaluations and Job Satisfaction

    Science.gov (United States)

    Wu, Chia-Huei; Griffin, Mark A.

    2012-01-01

    Core self-evaluations (CSE) have been proposed as a static personality trait that influences individuals' work experiences. However, CSE can also be influenced by work experiences. Based on the corresponsive principle of personality development, this study incorporated both dispositional and contextual perspectives to examine longitudinal…

  1. Longitudinal Relationships between Core Self-Evaluations and Job Satisfaction

    Science.gov (United States)

    Wu, Chia-Huei; Griffin, Mark A.

    2012-01-01

    Core self-evaluations (CSE) have been proposed as a static personality trait that influences individuals' work experiences. However, CSE can also be influenced by work experiences. Based on the corresponsive principle of personality development, this study incorporated both dispositional and contextual perspectives to examine longitudinal…

  2. Core Self-Evaluation and Goal Orientation: Understanding Work Stress

    Science.gov (United States)

    Morris, Michael Lane; Messal, Carrie B.; Meriac, John P.

    2013-01-01

    This study investigates the dispositional factors related to work stress. Specifically, previous research has demonstrated a relationship between core self-evaluation (CSE) and general life stress. This article extends past research by examining the relationship between CSE and work stress, and includes goal orientation as a potential mediator of…

  3. Elastic stability of superplastically formed/diffusion-bonded orthogonally corrugated core sandwich plates

    Science.gov (United States)

    Ko, W. L.

    1980-01-01

    The paper concerns the elastic buckling behavior of a newly developed superplastically formed/diffusion-bonded (SPF/DB) orthogonally corrugated core sandwich plate. Uniaxial buckling loads were calculated for this type of sandwich plate with simply supported edges by using orthotropic sandwich plate theory. The buckling behavior of this sandwich plate was then compared with that of an SPF/DB unidirectionally corrugated core sandwich plate under conditions of equal structural density. It was found that the buckling load for the former was considerably higher than that of the latter.

  4. Transformer design principles with applications to core-form power transformers

    CERN Document Server

    Del Vecchio, Robert M

    2010-01-01

    Updating and reorganizing the valuable information in the first edition to enhance logical development, Transformer Design Principles: With Applications to Core-Form Power Transformers, Second Edition remains focused on the basic physical concepts behind transformer design and operation. Starting with first principles, this book develops the reader's understanding of the rationale behind design practices by illustrating how basic formulae and modeling procedures are derived and used. Simplifies presentation and emphasizes fundamentals, making it easy to apply presented results to your own desi

  5. Forming the cores of giant planets from the radial pebble flux in protoplanetary discs

    CERN Document Server

    Lambrechts, Michiel

    2014-01-01

    The formation of planetary cores must proceed rapidly in order for the giant planets to accrete their gaseous envelopes before the dissipation of the protoplanetary gas disc ( 100 M_E), but preferentially form Neptune-mass planets or smaller (< 10 M_E). This is consistent with exoplanet surveys which show that gas giants are relatively uncommon around stars of low mass or low metallicity.

  6. Multibarrier waste forms. Part II. Characterization and evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Rusin, J.M.; Gray, W.J.; Wald, J.W.

    1979-08-01

    The multibarrier concept for the storage of radioactive waste is to use up to three barriers to isolate radionuclides from the environment: a solidified waste inner core, an impervious coating, and a metal matrix. The four multibarrier waste forms were evaluated for thermal stability (volatility), mechanical strength (impact resistance), and leach resistance. This report discusses the characterization of the multibarrier waste forms and compares them to reference calcine and glass waste forms. The weight loss of supercalcine-ceramics after 4 h in dry air ranges between 0.01 and 1.6 wt % from 1000 to 1200/sup 0/C and is dependent upon composition. Glass marbles in a cast lead alloy offer approximately an order of magnitude decease in the wt % fines < 37 ..mu..m released after impact as compared to a glass monolith. CVD-coated supercalcine in a sintered 410 SS matrix offers up to two orders of magnitude decrease. Hot-pressed supercalcine ceramics may offer no increase in impact resistance or leach resistance over that of a glass monolith. Supercalcine may offer no advantage over waste glasses in leach resistance. Glass and PyC/Al/sub 2/O/sub 3/ coatings provide effective inert leaching barriers.

  7. Solid dispersions in the form of electrospun core-sheath nanofibers

    Directory of Open Access Journals (Sweden)

    Yu DG

    2011-12-01

    Full Text Available Deng-GuangYu1, Li-Min Zhu2, Christopher J Branford-White3, Jun-He Yang1, Xia Wang1, Ying Li1, Wei Qian11School of Materials Science and Engineering, University of Shanghai for Science and Technology; 2College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, People's Republic of China; 3Faculty of Life Sciences, London Metropolitan University, London, United KingdomBackground: The objective of this investigation was to develop a new type of solid dispersion in the form of core-sheath nanofibers using coaxial electrospinning for poorly water-soluble drugs. Different functional ingredients can be placed in various parts of core-sheath nanofibers to improve synergistically the dissolution and permeation properties of encapsulated drugs and to enable drugs to exert their actions.Methods: Using acyclovir as a model drug, polyvinylpyrrolidone as the hydrophilic filament-forming polymer matrix, sodium dodecyl sulfate as a transmembrane enhancer, and sucralose as a sweetener, core-sheath nanofibers were successfully prepared, with the sheath part consisting of polyvinylpyrrolidone, sodium dodecyl sulfate, and sucralose, and the core part composed of polyvinylpyrrolidone and acyclovir.Results: The core-sheath nanofibers had an average diameter of 410 ± 94 nm with a uniform structure and smooth surface. Differential scanning calorimetry and x-ray diffraction results demonstrated that acyclovir, sodium dodecyl sulfate, and sucralose were well distributed in the polyvinylpyrrolidone matrix in an amorphous state due to favoring of second-order interactions. In vitro dissolution and permeation studies showed that the core-sheath nanofiber solid dispersions could rapidly release acyclovir within one minute, with an over six-fold increased permeation rate across the sublingual mucosa compared with that of crude acyclovir particles.Conclusion: The study reported here provides an example of the systematic design, preparation

  8. [Development and validation of a tool for evaluating core competencies in nursing cancer patients on chemotherapy].

    Science.gov (United States)

    Kim, Sung Hae; Park, Jae Hyun

    2012-10-01

    This study was done to develop tool to evaluate the core competencies regarding nursing cancer patients on chemotherapy, and to verify the reliability and efficacy of the developed tool. A tool to evaluate the core competencies was developed from a preliminary tool consisting of 112 items verified by expert groups. The adequacy of the preliminary tool was analyzed and refined to the final evaluation tool containing 76 items in 8 core competencies and 18 specific competencies. The evaluation tool is in the form of a self-report, and each item is evaluated according to a 3-point scale. From September 22 to October 14, 2011, 349 survey responses were analyzed using SPSS 20.0 and the WINSTEPS program that employs the Rasch model. Results indicated that there were no inappropriate items and the items had low levels of difficulty in comparison with the knowledge levels of the study participants. The results of factor analysis yielded 18 factors, and the reliability of the tools was very high with Cronbach's α=.97. The results of this study can be used for training and evaluation of core competencies for nursing cancer patients, and for standardizing nursing practices associated with chemotherapy.

  9. Density Profiles in Molecular Cloud Cores Associated with High-Mass Star-Forming Regions

    CERN Document Server

    Pirogov, Lev E

    2009-01-01

    Radial density profiles for the sample of dense cores associated with high-mass star-forming regions from southern hemisphere have been derived using the data of observations in continuum at 250 GHz. Radial density profiles for the inner regions of 16 cores (at distances $\\la 0.2-0.8$ pc from the center) are close on average to the $\\rho\\propto r^{-\\alpha}$ dependence, where $\\alpha=1.6\\pm 0.3$. In the outer regions density drops steeper. An analysis with various hydrostatic models showed that the modified Bonnor-Ebert model, which describes turbulent sphere confined by external pressure, is preferable compared with the logotrope and polytrope models practically in all cases. With a help of the Bonnor-Ebert model, estimates of central density in a core, non-thermal velocity dispersion and core size are obtained. The comparison of central densities with the densities derived earlier from the CS modeling reveals differences in several cases. The reasons of such differences are probably connected with the presen...

  10. The 3D Simulation of Liquid Core Change of Cylinder Steel Rolling Forming on Soft-reduction Continuous Casting Process

    Institute of Scientific and Technical Information of China (English)

    LUO Jian; WANG Ying; LI Ainong; HUA Lin

    2006-01-01

    Using ABAQUS FEM software, the Elastic-plastic with isotropic hardening model is applied to simulate 3D cylinder slab rolling forming in continuous casting (CC), the change of liquid core before slab solidification completely on soft reduction process is studied, the analyse result shows the soft reduction technique can change the liquid core size, which is useful to cylinder slab forming in CC.

  11. Numerical evaluation of gas core length in free surface vortices

    Science.gov (United States)

    Cristofano, L.; Nobili, M.; Caruso, G.

    2014-11-01

    The formation and evolution of free surface vortices represent an important topic in many hydraulic intakes, since strong whirlpools introduce swirl flow at the intake, and could cause entrainment of floating matters and gas. In particular, gas entrainment phenomena are an important safety issue for Sodium cooled Fast Reactors, because the introduction of gas bubbles within the core causes dangerous reactivity fluctuation. In this paper, a numerical evaluation of the gas core length in free surface vortices is presented, according to two different approaches. In the first one, a prediction method, developed by the Japanese researcher Sakai and his team, has been applied. This method is based on the Burgers vortex model, and it is able to estimate the gas core length of a free surface vortex starting from two parameters calculated with single-phase CFD simulations. The two parameters are the circulation and the downward velocity gradient. The other approach consists in performing a two-phase CFD simulation of a free surface vortex, in order to numerically reproduce the gas- liquid interface deformation. Mapped convergent mesh is used to reduce numerical error and a VOF (Volume Of Fluid) method was selected to track the gas-liquid interface. Two different turbulence models have been tested and analyzed. Experimental measurements of free surface vortices gas core length have been executed, using optical methods, and numerical results have been compared with experimental measurements. The computational domain and the boundary conditions of the CFD simulations were set consistently with the experimental test conditions.

  12. Forming Jupiter, Saturn, Uranus and Neptune in Few Million Years by Core Accretion

    CERN Document Server

    Benvenuto, Omar G; Brunini, Adrian

    2009-01-01

    Giant planet formation process is still not completely understood. The current most accepted paradigm, the core instability model, explains several observed properties of the solar system's giant planets but, to date, has faced difficulties to account for a formation time shorter than the observational estimates of protoplanetary disks' lifetimes, especially for the cases of Uranus and Neptune. In the context of this model, and considering a recently proposed primordial solar system orbital structure, we performed numerical calculations of giant planet formation. Our results show that if accreted planetesimals follow a size distribution in which most of the mass lies in 30-100 meter sized bodies, Jupiter, Saturn, Uranus and Neptune may have formed according to the nucleated instability scenario. The formation of each planet occurs within the time constraints and they end up with core masses in good agreement with present estimations.

  13. PGSFR Core Thermal Design Procedure to Evaluate the Safety Margin

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Sun Rock; Kim, Sang-Ji [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The Korea Atomic Energy Research Institute (KAERI) has performed a SFR design with the final goal of constructing a prototype plant by 2028. The main objective of the SFR prototype plant is to verify the TRU metal fuel performance, reactor operation, and transmutation ability of high-level wastes. The core thermal design is to ensure the safe fuel performance during the whole plant operation. Compared to the critical heat flux in typical light water reactors, nuclear fuel damage in SFR subassemblies arises from a creep induced failure. The creep limit is evaluated based on the maximum cladding temperature, power, neutron flux, and uncertainties in the design parameters, as shown in Fig. 1. In this work, the core thermal design procedures are compared to verify the present PGSFR methodology based on the nuclear plant design criteria/guidelines and previous SFR thermal design methods. The PGSFR core thermal design procedure is verified based on the nuclear plant design criteria/guidelines and previous methods in LWRs and SFRs. The present method aims to directly evaluate the fuel cladding failure and to assure more safety margin. The 2 uncertainty is similar to 95% one-side tolerance limit of 1.96 in LWRs. The HCFs, ITDP, and MCM reveal similar uncertainty propagation for cladding midwall temperature for typical SFR conditions. The present HCFs are mainly employed from the CRBR except the fuel-related uncertainty such as an incorrect fuel distribution. Preliminary PGSFR specific HCFs will be developed by the end of 2015.

  14. Evaluation of new indomethacin dosage forms.

    Science.gov (United States)

    Waller, E S

    1983-01-01

    Indomethacin, an indole derivative nonsteroidal anti-inflammatory drug, has been available since the early 1960s in gelatin capsules. In 1982, a sustained release product, Indocin SR, was marketed. Awaiting marketing approval is a unique controlled release form of indomethacin, Indos. The disposition of indomethacin includes enterohepatic cycling and extensive metabolism to inactive metabolites. Enterohepatic cycling makes interpretation of bioavailability estimates of indomethacin dosage forms difficult. The relationship of indomethacin plasma concentration to therapeutic effects and side effects is inconclusive. It appears in vivo prostaglandin inhibition occurs at very low plasma concentrations that are achievable with all available dosage forms. Indocin SR is a sustained release capsule of indomethacin designed to deliver 25 mg of drug immediately and 50 mg gradually. Absolute bioavailability of the product is 80%. The plasma concentration-time curves do not show good sustained release characteristics; after four hours plasma concentrations resemble those seen with a single dose of regular capsule. The cost compared with Indocin is competitive. Indos is a zero-order release form of indomethacin. It is a unique drug delivery system that shows good controlled release characteristics. Bioavailability is 85%. Both Indocin SR and Indos are apparently therapeutically equivalent to indomethacin capsules. In elderly patients, Indos has been shown to be associated with fewer side effects than Indocin. Both Indocin SR and Indos have the advantage of once or twice daily dosing.

  15. Preparedness for clinical: evaluation of the core elements of the Clinical Immersion curriculum model.

    Science.gov (United States)

    Diefenbeck, Cynthia; Herrman, Judith; Wade, Gail; Hayes, Evelyn; Voelmeck, Wayne; Cowperthwait, Amy; Norris, Susan

    2015-01-01

    The Clinical Immersion Model is an innovative baccalaureate nursing curriculum that has demonstrated successful outcomes over the past 10 years. For those intending to adopt the model, individual components in isolation may prove ineffective. This article describes three core components of the curriculum that form the foundation of preparation for the senior-year clinical immersion. Detailed student-centered outcomes evaluation of these critical components is shared. Results of a mixed-methods evaluation, including surveys and focus groups, are presented. Implications of this curricular evaluation and future directions are explored.

  16. Kinetic and Thermodynamic Characterization of the Cobalt and Manganese Oxyhydroxide Cores Formed in Horse Spleen Ferritin

    Science.gov (United States)

    Zhang, Bo; Harb, John N.; Davis, Robert C.; Kim, Jae-Woo; Chu, Sang-Hyon; Choi, Sang; Miller, Tim; Watt, Gerald D.

    2004-01-01

    Horse spleen ferritin (HoSF) containing 800-1500 cobalt or 250-1200 manganese atoms as Co(O)OH and Mn(O)OH mineral cores within the HoSF interior (Co-HoSF and Mn-HoSF) was synthesized, and the chemical reactivity, kinetics of reduction, and the reduction potentials were measured. Microcoulometric and chemical reduction of HoSF containing the M(O)OH mineral core (M = Co or Mn) was rapid and quantitative with a reduction stoichiometry of 1.05+/-0.10 e/M forming a stable M(OH)2 mineral core. At pH 9.0, ascorbic acid (AH2), a two-electron reductant, effectively reduced the mineral cores; however, the reaction was incomplete and rapidly reached equilibrium. The addition of excess AH2 shifted the reaction to completion with a M(3+)/AH2 stoichiometry of 1.9-2.1, consistent with a single electron per metal atom reduction. The rate of reaction between M(0)OH and excess AH2 was measured by monitoring the decrease in mineral core absorbance with time. The reaction was first order in each reactant with second-order rate constants of 0.53 and 4.74/M/min, respectively, for Co- and Mn-HoSF at pH 9.0. From the variation of absorbance with increasing AH2 concentration, equilibrium constants at pH 9.0 of 5.0+/-1.9 for Co-HoSF and 2.9+/-0.9 for Mn-HoSF were calculated for 2M(O)OH + AH2 = 2M(OH)2 f D, where AH2 and D are ascorbic acid and dehydroascorbic acid, respectively. Consistent with these equilibrium constants, the standard potential for the reduction of Co(III)-HoSF is 42 mV more positive than that of the ascorbic acid reaction, while the standard potential of Mn(III)-HoSF is 27 mV positive relative to AH2. Fe(2+) in solution with Co- and Mn-HoSF under anaerobic conditions was oxidized to form Fe(O)OH within the HoSF interior, resulting in partial displacement of the Co or Mn by iron.

  17. Chemical segregation toward massive hot cores: The AFGL2591 star forming region

    CERN Document Server

    Jimenez-Serra, I; Viti, S; Martin-Pintado, J; de Wit, W -J

    2012-01-01

    We present high angular resolution observations (0.5"x0.3") carried out with the Submillimeter Array (SMA) toward the AFGL2591 high-mass star forming region. Our SMA images reveal a clear chemical segregation within the AFGL2591 VLA 3 hot core, where different molecular species (Type I, II and III) appear distributed in three concentric shells. This is the first time that such a chemical segregation is ever reported at linear scales <3000 AU within a hot core. While Type I species (H2S and 13CS) peak at the AFGL2591 VLA 3 protostar, Type II molecules (HC3N, OCS, SO and SO2) show a double-peaked structure circumventing the continuum peak. Type III species, represented by CH3OH, form a ring-like structure surrounding the continuum emission. The excitation temperatures of SO2, HC3N and CH3OH (185+-11 K, 150+-20 K and 124+-12 K, respectively) show a temperature gradient within the AFGL2591 VLA 3 envelope, consistent with previous observations and modeling of the source. By combining the H2S, SO2 and CH3OH imag...

  18. Evaluation of the influence of bypass flow gap distribution on the core hot spot in a prismatic VHTR core

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min-Hwan, E-mail: mhkim@kaeri.re.kr [Korea Atomic Energy Research Institute, 1045 Daedeokdaero, Yoseong, Daejeon 304-353 (Korea, Republic of); Lim, Hong-Sik [Korea Atomic Energy Research Institute, 1045 Daedeokdaero, Yoseong, Daejeon 304-353 (Korea, Republic of)

    2011-08-15

    Highlights: > A procedure to evaluate the local gap size variation between graphite blocks was developed and applied to a prismatic core VHTR. > The analysis for the core bypass flow and hot spot was carried out based on the calculated gap distributions. > The predicted gap size is large enough to affect the flow distribution in the core. > The bypass gap and flow distributions are closely related to the local hot spot temperature and its location. > The core restraint mechanism preventing outward movement of graphite block reduces the bypass gap size and hot spot temperature. - Abstract: Core bypass flow in VHTR is one of the key issues for core thermal margins and efficiency. The bypass flow in the prismatic core varies during core cycles due to the irradiation shrinkage/swelling and thermal expansion of the graphite blocks. A procedure to evaluate the local gap size variation between graphite blocks was developed and applied to a prismatic core VHTR. The influence of the core restraint mechanism on the bypass flow gap was evaluated. The predicted gap size is as much as 8 mm when the graphite block is exposed to its allowable limit of fast neutron fluence. The analysis for the core bypass flow and hot spot was carried out based on the calculated gap distributions. The results indicate that the bypass gap and flow distributions are closely related to the local hot spot and its location and the core restraint mechanism preventing outward movement of the graphite block by a fastening device reduces the bypass gap size, which results in the decrease of maximum fuel temperature not less than 100 deg. C, when compared to the case without it.

  19. Performance evaluation of open core gasifier on multi-fuels

    Energy Technology Data Exchange (ETDEWEB)

    Bhoi, P.R.; Singh, R.N.; Sharma, A.M.; Patel, S.R. [Thermo Chemical Conversion Division, Sardar Patel Renewable Energy Research Institute (SPRERI), Vallabh Vidyanagar 388 120, Gujarat (India)

    2006-06-15

    Sardar Patel renewable energy research institute (SPRERI) has designed and developed open core, throat-less, down draft gasifier and installed it at the institute. The gasifier was designed for loose agricultural residues like groundnut shells. The purpose of the study is to evaluate the gasifier on multi-fuels such as babul wood (Prosopis juliflora), groundnut shell briquettes, groundnut shell, mixture of wood (Prosopis juliflora) and groundnut shell in the ratio of 1:1 and cashew nut shell. The gasifier performance was evaluated in terms of fuel consumption rate, calorific value of producer gas and gasification efficiency. Gasification efficiency of babul wood (Prosopis juliflora), groundnut shell briquettes, groundnut shell, mixture of Prosopis juliflora and groundnut shell in the ratio of 1:1 and cashew nut shell were 72%, 66%, 70%, 64%, 70%, respectively. Study revealed that babul wood (Prosopis juliflora), groundnut shell briquettes, groundnut shell, mixture of wood (Prosopis juliflora) and groundnut shell in the ratio of 1:1 and cashew nut shell were satisfactorily gasified in open core down draft gasifier. The study also showed that there was flow problem with groundnut shell. (author)

  20. Benchmark Evaluation of the NRAD Reactor LEU Core Startup Measurements

    Energy Technology Data Exchange (ETDEWEB)

    J. D. Bess; T. L. Maddock; M. A. Marshall

    2011-09-01

    The Neutron Radiography (NRAD) reactor is a 250-kW TRIGA-(Training, Research, Isotope Production, General Atomics)-conversion-type reactor at the Idaho National Laboratory; it is primarily used for neutron radiography analysis of irradiated and unirradiated fuels and materials. The NRAD reactor was converted from HEU to LEU fuel with 60 fuel elements and brought critical on March 31, 2010. This configuration of the NRAD reactor has been evaluated as an acceptable benchmark experiment and is available in the 2011 editions of the International Handbook of Evaluated Criticality Safety Benchmark Experiments (ICSBEP Handbook) and the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook). Significant effort went into precisely characterizing all aspects of the reactor core dimensions and material properties; detailed analyses of reactor parameters minimized experimental uncertainties. The largest contributors to the total benchmark uncertainty were the 234U, 236U, Er, and Hf content in the fuel; the manganese content in the stainless steel cladding; and the unknown level of water saturation in the graphite reflector blocks. A simplified benchmark model of the NRAD reactor was prepared with a keff of 1.0012 {+-} 0.0029 (1s). Monte Carlo calculations with MCNP5 and KENO-VI and various neutron cross section libraries were performed and compared with the benchmark eigenvalue for the 60-fuel-element core configuration; all calculated eigenvalues are between 0.3 and 0.8% greater than the benchmark value. Benchmark evaluations of the NRAD reactor are beneficial in understanding biases and uncertainties affecting criticality safety analyses of storage, handling, or transportation applications with LEU-Er-Zr-H fuel.

  1. Challenges in forming the solar system's giant planet cores via pebble accretion

    Energy Technology Data Exchange (ETDEWEB)

    Kretke, K. A.; Levison, H. F., E-mail: kretke@boulder.swri.edu [Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States)

    2014-12-01

    Though ∼10 M {sub ⊕} mass rocky/icy cores are commonly held as a prerequisite for the formation of gas giants, theoretical models still struggle to explain how these embryos can form within the lifetimes of gaseous circumstellar disks. In recent years, aerodynamic-aided accretion of 'pebbles', objects ranging from centimeters to meters in size, has been suggested as a potential solution to this long-standing problem. While pebble accretion has been demonstrated to be extremely effective in local simulations that look at the detailed behavior of these pebbles in the vicinity of a single planetary embryo, to date there have been no global simulations demonstrating the effectiveness of pebble accretion in a more complicated, multi-planet environment. Therefore, we have incorporated the aerodynamic-aided accretion physics into LIPAD, a Lagrangian code that can follow the collisional/accretional/dynamical evolution of a protoplanetary system, to investigate how pebble accretion manifests itself in the larger planet formation picture. We find that under generic circumstances, pebble accretion naturally leads to an 'oligarchic' type of growth in which a large number of planetesimals grow to similar-sized planets. In particular, our simulations tend to form hundreds of Mars- and Earth-mass objects between 4 and 10 AU. While merging of some oligarchs may grow massive enough to form giant planet cores, leftover oligarchs lead to planetary systems that cannot be consistent with our own solar system. We investigate various ideas presented in the literature (including evaporation fronts and planet traps) and find that none easily overcome this tendency toward oligarchic growth.

  2. Externally heated protostellar cores in the Ophiuchus star-forming region

    CERN Document Server

    Lindberg, Johan E; Jørgensen, Jes K; Cordiner, Martin A; Bjerkeli, Per

    2016-01-01

    We present APEX 218 GHz observations of molecular emission in a complete sample of embedded protostars in the Ophiuchus star-forming region. To study the physical properties of the cores, we calculate H$_2$CO and c-C$_3$H$_2$ rotational temperatures, both of which are good tracers of the kinetic temperature of the molecular gas. We find that the H$_2$CO temperatures range between 16 K and 124 K, with the highest H$_2$CO temperatures toward the hot corino source IRAS 16293-2422 (69-124 K) and the sources in the $\\rho$ Oph A cloud (23-49 K) located close to the luminous Herbig Be star S 1, which externally irradiates the $\\rho$ Oph A cores. On the other hand, the c-C$_3$H$_2$ rotational temperature is consistently low (7-17 K) in all sources. Our results indicate that the c-C$_3$H$_2$ emission is primarily tracing more shielded parts of the envelope whereas the H$_2$CO emission (at the angular scale of the APEX beam; 3600 au in Ophiuchus) mainly traces the outer irradiated envelopes, apart from in IRAS 16293-24...

  3. Challenges in Forming the Solar System's Giant Planet Cores via Pebble Accretion

    CERN Document Server

    Kretke, K A

    2014-01-01

    Though ~10 Earth mass rocky/icy cores are commonly held as a prerequisite for the formation of gas giants, theoretical models still struggle to explain how these embryos can form within the lifetimes of gaseous circumstellar disks. In recent years, aerodynamic-aided accretion of "pebbles," objects ranging from centimeters to meters in size, has been suggested as a potential solution to this long-standing problem. While pebble accretion has been demonstrated to be extremely effective in local simulations that look at the detailed behavior of these pebbles in the vicinity of a single planetary embryo, to date there have been no global simulations demonstrating the effectiveness of pebble accretion in a more complicated, multi-planet environment. Therefore, we have incorporated the aerodynamic-aided accretion physics into LIPAD, a Lagrangian code which can follow the collisional / accretional / dynamical evolution of a protoplanetary system, to investigate the how pebble accretion manifests itself in the larger ...

  4. Evidence of Evolution in the Dense Cores in Massive Star Forming Regions

    Institute of Scientific and Technical Information of China (English)

    Jian-Jun Zhou; Jarken Esimbek; Ji-Xian Sun; Bing-Gang Ju; Jing-Jiang Sun

    2005-01-01

    The excitation of H2O masers usually needs very high density gas,hence it can serve as a marker of dense gas in HⅡ region. We selected a sample of H2O maser sources from Plume et al. (four with, and four without detected CS(J = 7 - 6) emission), and observed them in 13CO(J=1-0) and C18O (J=1-0). C18O (J=1-0) emission was detected only in three of the sources with detected CS(J=7-6) emission. An analysis combined with some data in the literature suggests that these dense cores may be located at different evolutionary stages. Multi-line observation study may provide us clues on the evolution of massive star forming regions and the massive stars themselves.

  5. The Evaluation of Hepatitis C Virus Core Antigen in Immunized Balb/C Mice

    Directory of Open Access Journals (Sweden)

    Elham Torbati

    2012-06-01

    Full Text Available Background: Hepatitis infection represents one of the important causes of morbidity and mortality in developing countries, however there is not any effective vaccine against hepatitis C which is one of the significant problems in vaccine project.Objectives: The aim of the present study is to evaluate the role of HCV core protein in inducing IFN-Gamma secretion and TCL activities as a vaccine in Balb/C mice.Material and Methods: Our previous cloned plasmid (HCV Core gene into pETDuet-1 applied for protein expression in bacteria. The expressed and purified recombinant protein together with Freund’s adjuvant was injected to 15 Balb/c mice. The total IgG and IgG2a of immunized mice sera were evaluated after a week. Two weeks after booster injection, we studied the proliferation and IFNγ secretion of spleens, inguinal and popliteal lymph nodes lymphocytes by ELISA and ELISPOT.Results: The FSFC (Frequency of spot forming cells of secreting cells of immunized mice with HCV/Core protein and sera IgG2a were considerably higher than the control groups.Conclusions: The core protein together with proper adjuvant can be a candidate vaccine against of HCV infection..

  6. Patient experience and satisfaction with inpatient service: development of short form survey instrument measuring the core aspect of inpatient experience.

    Directory of Open Access Journals (Sweden)

    Eliza L Y Wong

    Full Text Available Patient experience reflects quality of care from the patients' perspective; therefore, patients' experiences are important data in the evaluation of the quality of health services. The development of an abbreviated, reliable and valid instrument for measuring inpatients' experience would reflect the key aspect of inpatient care from patients' perspective as well as facilitate quality improvement by cultivating patient engagement and allow the trends in patient satisfaction and experience to be measured regularly. The study developed a short-form inpatient instrument and tested its ability to capture a core set of inpatients' experiences. The Hong Kong Inpatient Experience Questionnaire (HKIEQ was established in 2010; it is an adaptation of the General Inpatient Questionnaire of the Care Quality Commission created by the Picker Institute in United Kingdom. This study used a consensus conference and a cross-sectional validation survey to create and validate a short-form of the Hong Kong Inpatient Experience Questionnaire (SF-HKIEQ. The short-form, the SF-HKIEQ, consisted of 18 items derived from the HKIEQ. The 18 items mainly covered relational aspects of care under four dimensions of the patient's journey: hospital staff, patient care and treatment, information on leaving the hospital, and overall impression. The SF-HKIEQ had a high degree of face validity, construct validity and internal reliability. The validated SF-HKIEQ reflects the relevant core aspects of inpatients' experience in a hospital setting. It provides a quick reference tool for quality improvement purposes and a platform that allows both healthcare staff and patients to monitor the quality of hospital care over time.

  7. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  8. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  9. INNOVATIVE TECHNOLOGY EVALUATION REPORT, SEDIMENT SAMPLING TECHNOLOGY, ART'S MANUFACTURING, SPLIT CORE SAMPLER FOR SUBMERGED SEDIMENTS

    Science.gov (United States)

    The Split Core Sampler for Submerged Sediments (Split Core Sampler) designed and fabricated by Arts Manufacturing & Supply, Inc., was demonstrated under the U.S. Environmental Protection Agency (EPA) Superfund Innovative Technology Evaluation Program in April and May 1999 at ...

  10. Evaluation of Ceramic Honeycomb Core Compression Behavior at Room Temperature

    Science.gov (United States)

    Bird, Richard K.; Lapointe, Thomas S.

    2013-01-01

    Room temperature flatwise compression tests were conducted on two varieties of ceramic honeycomb core specimens that have potential for high-temperature structural applications. One set of specimens was fabricated using strips of a commercially-available thin-gage "ceramic paper" sheet molded into a hexagonal core configuration. The other set was fabricated by machining honeycomb core directly from a commercially available rigid insulation tile material. This paper summarizes the results from these tests.

  11. EVLA Observations of the Barnard 5 Star-Forming Core: Embedded Filaments Revealed

    CERN Document Server

    Pineda, Jaime E; Arce, Héctor G; Caselli, Paola; Longmore, Steven; Corder, Stuartt

    2011-01-01

    We present a ~6.5'x8' Expanded Very Large Array (EVLA) mosaic observations of the NH3 (1,1) emission in the Barnard 5 region in Perseus, with an angular resolution of 6". This map covers the coherent region, where the dense gas presents subsonic non-thermal motions (as seen from single dish observations with the Green Bank Telescope, GBT). The combined EVLA and GBT observations reveal, for the first time, a striking filamentary structure (20" wide or 5,000 AU at the distance of Perseus) in this low-mass star forming region. The integrated intensity profile of this structure is consistent with models of an isothermal filament in hydrostatic equilibrium. The observed separation between the B5-IRS1 young stellar object (YSO), in the central region of the core, and the northern starless condensation matches the Jeans length of the dense gas. This suggests that the dense gas in the coherent region is fragmenting. The region observed displays a narrow velocity dispersion, where most of the gas shows evidence for su...

  12. Discovery of Extremely Embedded X-ray Sources in the R Coronae Australis Star Forming Core

    CERN Document Server

    Hamaguchi, K; Petre, R; White, N E; Stelzer, B; Nedachi, K; Kobayashi, N; Tokunaga, A T; Hamaguchi, Kenji; Corcoran, Michael F.; Petre, Rob; White, Nicholas E.; Stelzer, Beate; Nedachi, Ko; Kobayashi, Naoto; Tokunaga, Alan T.

    2005-01-01

    With the XMM-Newton and Chandra observatories, we detected two extremely embedded X-ray sources in the R Corona Australis (R CrA) star forming core, near IRS 7. These sources, designated as XB and XA, have X-ray absorption columns of ~3e23 cm-2 equivalent to AV ~180 mag. They are associated with the VLA centimeter radio sources 10E and 10W, respectively. XA is the counterpart of the near-infrared source IRS 7, whereas XB has no K-band counterpart above 19.4 mag. This indicates that XB is younger than typical Class I protostars, probably a Class 0 protostar or in an intermediate phase between Class 0 and Class I. The X-ray luminosity of XB varied between 29

  13. Evaluation and selection of candidate high-level waste forms

    Energy Technology Data Exchange (ETDEWEB)

    Bernadzikowski, T. A.; Allender, J. S.; Butler, J. L.; Gordon, D. E.; Gould, Jr., T. H.; Stone, J. A.

    1982-03-01

    Seven candidate waste forms being developed under the direction of the Department of Energy's National High-Level Waste (HLW) Technology Program, were evaluated as potential media for the immobilization and geologic disposal of high-level nuclear wastes. The evaluation combined preliminary waste form evaluations conducted at DOE defense waste-sites and independent laboratories, peer review assessments, a product performance evaluation, and a processability analysis. Based on the combined results of these four inputs, two of the seven forms, borosilicate glass and a titanate based ceramic, SYNROC, were selected as the reference and alternative forms for continued development and evaluation in the National HLW Program. Both the glass and ceramic forms are viable candidates for use at each of the DOE defense waste-sites; they are also potential candidates for immobilization of commercial reprocessing wastes. This report describes the waste form screening process, and discusses each of the four major inputs considered in the selection of the two forms.

  14. Self-Healing Many-Core Architecture: Analysis and Evaluation

    Directory of Open Access Journals (Sweden)

    Arezoo Kamran

    2016-01-01

    Full Text Available More pronounced aging effects, more frequent early-life failures, and incomplete testing and verification processes due to time-to-market pressure in new fabrication technologies impose reliability challenges on forthcoming systems. A promising solution to these reliability challenges is self-test and self-reconfiguration with no or limited external control. In this work a scalable self-test mechanism for periodic online testing of many-core processor has been proposed. This test mechanism facilitates autonomous detection and omission of faulty cores and makes graceful degradation of the many-core architecture possible. Several test components are incorporated in the many-core architecture that distribute test stimuli, suspend normal operation of individual processing cores, apply test, and detect faulty cores. Test is performed concurrently with the system normal operation without any noticeable downtime at the application level. Experimental results show that the proposed test architecture is extensively scalable in terms of hardware overhead and performance overhead that makes it applicable to many-cores with more than a thousand processing cores.

  15. Evaluation of long-term post-accident core cooling of Three Mile Island Unit 2

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-04-15

    On the basis of current understanding of the accident scenario and available data, the staff reports here on its evaluation of the condition of the core and the core flow resistance as it might affect ability to cool the core by natural circulation. The natural circulation cooling capability of TMI-2 for the estimated core flow resistance and a variety of other conditions is evaluated and a comparison of the Base Case and off-nominal plant configurations is presented. The potential for and effects of natural convection core cooling are addressed, and the staff recommendations for reactor performance acceptance criteria upon initiation of natural convection are presented.

  16. Development of Monju easy-to-introduce system for total evaluation of reactor core

    Energy Technology Data Exchange (ETDEWEB)

    Kitano, Akihiro; Teruyama, Hidehiko; Nishi, Hiroshi [Japan Nuclear Cycle Development Inst., Tsuruga Head Office, Tsuruga, Fukui (Japan); Yamaoka, Mitsuaki; Moriki, Yasuyuki [Toshiba Corp., Tokyo (Japan); Nakagawa, Masatoshi [AITEL Corp., Tokyo (Japan)

    2002-06-01

    An interactive core analysis tool for use on a PC MEISTER (Monju Easy-to-Introduce System for Total Evaluation of Reactor Core) has been developed, enabling evaluation of the overall core characteristics, including core physics, thermal hydraulics and structural integrity, in an easy but accurate manner. Data processing, such as the preparation of input data, data transfer from one code to another or display of output data, can be achieved in a systematic manner by graphical user interfaces. MEISTER has been verified by the analysis of core criticality, control rod worth and the maximum linear heat rate measured in the Monju start-up tests. (author)

  17. Cerebral vascular accident: some characteristics of occupational therapy evaluation forms.

    Science.gov (United States)

    Ottenbacher, K

    1980-04-01

    To determine areas most commonly evaluated by occupational therapists and to ascertain methods in which evaluative information is gathered, 35 evaluation forms currently employed by occupational therapists to assess dysfunction in patients with cerebral vascular accident were collected. Five general areas including motor function, sensory deficit, hadn function, activities of daily living, and visual perception were found to be most frequently listed on the forms. These areas were divided into sub areas to operationally define the information collected. Analysis revealed that the level of measurement most frequently employed by therapists to record evaluate findings was the descriptive level. There was a tendency to collect data at "higher" or more sophisticated levels of measurement in those areas evaluated most frequently. The findings are discussed in relation to professional competency concerns and the need to develop unique occupational therapy evaluative instruments for areas of practice such as cerebral vascular accident.

  18. Analytical evaluation of atomic form factors: application to Rayleigh scattering

    CERN Document Server

    Safari, L; Amaro, P; Jänkälä, K; Fratini, F

    2014-01-01

    Atomic form factors are widely used for the characterization of targets and specimens, from crystallography to biology. By using recent mathematical results, here we derive an analytical expression for the atomic form factor within the independent particle model constructed from nonrelativistic screened hydrogenic wavefunctions. The range of validity of this analytical expression is checked by comparing the analytically obtained form factors with the ones obtained within the Hartee-Fock method. As an example, we apply our analytical expression for the atomic form factor to evaluate the differential cross section for Rayleigh scattering off neutral atoms.

  19. Early-stage star forming cloud cores in GLIMPSE Extended Green Objects (EGOs) as traced by organics pecies

    CERN Document Server

    Ge, Jixing; Chen, Xi; Takahashi, S

    2014-01-01

    In order to investigate the physical and chemical properties of massive star forming cores in early stages, we analyse the excitation and abundance of four organic species, CH3OH, CH3OCH3, HCOOCH3 and CH3CH2CN, toward 29 Extended Green Object (EGO) cloud cores that were observed by our previous single dish spectral line survey. The EGO cloud cores are found to have similar methanol J_3-J_2 rotation temperatures of ~44 K, a typical linear size of ~0.036 pc, and a typical beam averaged methanol abundance of several 10^(-9) (the beam corrected value could reach several 10^(-7)). The abundances of the latter three species, normalized by that of methanol, are found to be correlated also across a large variety of clouds such as EGO cloud cores, hot corinos, massive hot cores and Galactic Center clouds. The chemical properties of the EGO cloud cores lie between that of hot cores and hot corinos. However, the abundances and abundance ratios of the four species can not be satisfactorily explained by recent chemical mo...

  20. Wettability evaluation of a carbonate reservoir rock from core to pore level

    Energy Technology Data Exchange (ETDEWEB)

    Al-Yousef, H.Y.; Lichaa, P.M.; Al-Kaabi, A.U.; Alpustun, H.

    1995-10-01

    Wettability evaluation was performed during stags of as received, cleaned, and restored states on core samples form a Saudi Arabian carbonate reservoir. The wettability behavior from the chemistry of brine-oil-carbonate rock interaction was found to be neutral to slightly oil-wet. The pore-size distribution obtained from mercury injection data indicated that about 15--20 percent of the pore volume is not accessible to asphaltene particles in the crude oil. Therefore a mixed-wettability state can exist. These results were confirmed by the evaluation of the wettability of the cores using USBM and Amott techniques. The wettability at the pore level was studied using Cryo-Scanning Electron Microscopy. Rock samples were examined at irreducible water and residual oil saturations during cleaned and restored states. At irreducible water saturation, both oil and brine were present in the intergranular macroporosity and intragranular macropores and micropores. At residual oil saturation,oil was found in the form of isolated globules in the cleaned case. After aging, the oil is more loosely distributed in the porosity and generally contacts the pore walls. This indicates an evolution toward oil wetness with aging. These results are in agreement with the changes of wettability indices obtained using USBM technique.

  1. Review of the Educational Software Evaluation Forms and Scales

    Directory of Open Access Journals (Sweden)

    Ahmet ARSLAN

    2016-12-01

    Full Text Available The main purpose of this study is to review existing evaluation forms and scales that have been prepared for educational software evaluation. In addition to this purpose, the study aims to provide insight and guidance for future studies in this context. In total, forty-two studies that including evaluation forms and scales have been taken into consideration. “Educational software evaluation”, “Software evaluation”, “Educational software evaluation forms/scales” were searched as keywords in the: “Education Resources Information Centre (ERIC”, “Marmara University e-Library”, “National Thesis Center” and “Science Direct” databases. Twenty-nine of them have met the review selection criteria and been evaluated. There is an increase in the number of evaluation tools between 2006 – 2010. However, it was noticed that there is no sufficient number of evaluation tools targeting “educational games”. It was concluded that reliability and validity studies are very important part of developing educational software evaluation tools and this is a matter that should be considered in future studies.

  2. Hexagonal Boron Nitride-Graphene Core-Shell Arrays Formed by Self-Symmetrical Etching Growth.

    Science.gov (United States)

    Wang, Chenxiao; Zuo, Junlai; Tan, Lifang; Zeng, Mengqi; Zhang, Qiqi; Xia, Huinan; Zhang, Wenhao; Fu, Yingshuang; Fu, Lei

    2017-09-20

    The synthesis and integration of core-shell materials have been extensively explored in three-dimensional nanostructures, while they are hardly ever extended into the emerging two-dimensional (2D) research field. Herein, demonstrated by graphene (G) and hexagonal boron nitride (h-BN) and via a sequential chemical vapor deposition method, we succeed for the first time in synthesizing 2D h-BN-G core-shell arrays (CSA), which possess extremely high uniformity in shapes, sizes and distributions. Each of the core-shell unit is composed of G ring-shaped shell internally filled with h-BN circular core. In addition, we perform simulations to further explain the self-symmetrical etching growth mechanism of the h-BN-G CSA, demonstrating its potential to be used as an efficient synthetic method suitable for other 2D CSA systems.

  3. A Preliminary Paleomagnetic Rsult of Quaternary Drilling Core form Southern Leizhou Peninsula,Guangdong Province

    Institute of Scientific and Technical Information of China (English)

    王俊达; 梁池生; 等

    1999-01-01

    313 orientated samples were collected from Drilling Core ZK1 in southern Leizhou Peninsula for the study of Quaternary paleomagnetic strato-chronology.Te polarity measurement results indicate that the core recorded paleomagnetic information in three main parts:the upper one of the core,from the ground surface to the depth of 39m ,is normally magnetized in polarity,the middle one,from 39m 59 210m in depth,mainly shows reversed polarity and the lower one recorded normal polarity again.They correspond to the Brunhes normal chron,the Matuyama reversed chron and the Guass normal chron in the geomagnetic polarity time scale,respectively.The age of he core could be over 3.4Ma.Meanwhile,the magnetic susceptibility was measured and its result is significant for stratigraphic division and paleoclimatic research.

  4. In vitro evaluation of the fracture strength of all-ceramic core materials on zirconium posts.

    Science.gov (United States)

    Ozcan, Nihal; Sahin, Erdal

    2013-10-01

    For most endodontically treated teeth, tooth-colored post-core systems are preferable for esthetic reasons. Therefore, improvements in material strength must also consider tooth colored post-core complexes. The objective of this study was to evaluate the difference in tooth colored post-core complex strengths. A total of 33 human maxillary central incisor teeth were used for this study, with three groups of 11 teeth. Three different methods were used to fabricate all-ceramic post-core restorations: zirconia blanks, Cerec 3D-milled to one-piece post-core restorations (Test Group 1); feldspathic cores (from feldspathic prefabricated CAD/CAM blocks) adhesively luted to CosmoPost zirconia posts (Test Group 2); and IPS Empress cores directly pressed to CosmoPost zirconia posts (Test Group 3). All-ceramic crowns from feldspathic ceramic were constructed using a CAD/CAM system (Cerec 3D) for all specimens. The post-core complexes were tested to failure with the load applied at 45° angled relative to the tooth long axis. The load at fracture was recorded. The maximum fracture strength of the milled zirconia cores (Test Group 1) was 577 N; corresponding values for the milled feldspathic cores (Test Group 2) and the pressed cores (Test Group 3) were 586 and 585 N, respectively. Differences were not statistically significant at P cores adhesively luted on zirconia posts and one-piece all-ceramic zirconium post-core structures offer a viable alternative to conventional pressing.

  5. Evaluation of the Start-Up Core Physics Tests at Japan's High Temperature Engineering Test Reactor (Annular Core Loadings)

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess; Nozomu Fujimoto; James W. Sterbentz; Luka Snoj; Atsushi Zukeran

    2010-03-01

    The High Temperature Engineering Test Reactor (HTTR) of the Japan Atomic Energy Agency (JAEA) is a 30 MWth, graphite-moderated, helium-cooled reactor that was constructed with the objectives to establish and upgrade the technological basis for advanced high-temperature gas-cooled reactors (HTGRs) as well as to conduct various irradiation tests for innovative high-temperature research. The core size of the HTTR represents about one-half of that of future HTGRs, and the high excess reactivity of the HTTR, necessary for compensation of temperature, xenon, and burnup effects during power operations, is similar to that of future HTGRs. During the start-up core physics tests of the HTTR, various annular cores were formed to provide experimental data for verification of design codes for future HTGRs. The Japanese government approved construction of the HTTR in the 1989 fiscal year budget; construction began at the Oarai Research and Development Center in March 1991 and was completed May 1996. Fuel loading began July 1, 1998, from the core periphery. The first criticality was attained with an annular core on November 10, 1998 at 14:18, followed by a series of start-up core physics tests until a fully-loaded core was developed on December 16, 1998. Criticality tests were carried out into January 1999. The first full power operation with an average core outlet temperature of 850ºC was completed on December 7, 2001, and operational licensing of the HTTR was approved on March 6, 2002. The HTTR attained high temperature operation at 950 ºC in April 19, 2004. After a series of safety demonstration tests, it will be used as the heat source in a hydrogen production system by 2015. Hot zero-power critical, rise-to-power, irradiation, and safety demonstration testing , have also been performed with the HTTR, representing additional means for computational validation efforts. Power tests were performed in steps from 0 to 30 MW, with various tests performed at each step to confirm

  6. Magnetized Converging Flows toward the Hot Core in the Intermediate/High-mass Star-forming Region NGC 6334 V

    Science.gov (United States)

    Juárez, Carmen; Girart, Josep M.; Zamora-Avilés, Manuel; Tang, Ya-Wen; Koch, Patrick M.; Liu, Hauyu Baobab; Palau, Aina; Ballesteros-Paredes, Javier; Zhang, Qizhou; Qiu, Keping

    2017-07-01

    We present Submillimeter Array (SMA) observations at 345 GHz toward the intermediate/high-mass cluster-forming region NGC 6334 V. From the dust emission we spatially resolve three dense condensations, the brightest one presenting the typical chemistry of a hot core. The magnetic field (derived from the dust polarized emission) shows a bimodal converging pattern toward the hot core. The molecular emission traces two filamentary structures at two different velocities, separated by 2 km s-1, converging to the hot core and following the magnetic field distribution. We compare the velocity field and the magnetic field derived from the SMA observations with magnetohydrodynamic simulations of star-forming regions dominated by gravity. This comparison allows us to show how the gas falls in from the larger-scale extended dense core (˜0.1 pc) of NGC 6334 V toward the higher-density hot core region (˜0.02 pc) through two distinctive converging flows dragging the magnetic field, whose strength seems to have been overcome by gravity.

  7. Cross-platform digital assessment forms for evaluating surgical skills

    Directory of Open Access Journals (Sweden)

    Steven Arild Wuyts Andersen

    2015-04-01

    Full Text Available A variety of structured assessment tools for use in surgical training have been reported, but extant assessment tools often employ paper-based rating forms. Digital assessment forms for evaluating surgical skills could potentially offer advantages over paper-based forms, especially in complex assessment situations. In this paper, we report on the development of cross-platform digital assessment forms for use with multiple raters in order to facilitate the automatic processing of surgical skills assessments that include structured ratings. The FileMaker 13 platform was used to create a database containing the digital assessment forms, because this software has cross-platform functionality on both desktop computers and handheld devices. The database is hosted online, and the rating forms can therefore also be accessed through most modern web browsers. Cross-platform digital assessment forms were developed for the rating of surgical skills. The database platform used in this study was reasonably priced, intuitive for the user, and flexible. The forms have been provided online as free downloads that may serve as the basis for further development or as inspiration for future efforts. In conclusion, digital assessment forms can be used for the structured rating of surgical skills and have the potential to be especially useful in complex assessment situations with multiple raters, repeated assessments in various times and locations, and situations requiring substantial subsequent data processing or complex score calculations.

  8. Cross-platform digital assessment forms for evaluating surgical skills.

    Science.gov (United States)

    Andersen, Steven Arild Wuyts

    2015-01-01

    A variety of structured assessment tools for use in surgical training have been reported, but extant assessment tools often employ paper-based rating forms. Digital assessment forms for evaluating surgical skills could potentially offer advantages over paper-based forms, especially in complex assessment situations. In this paper, we report on the development of cross-platform digital assessment forms for use with multiple raters in order to facilitate the automatic processing of surgical skills assessments that include structured ratings. The FileMaker 13 platform was used to create a database containing the digital assessment forms, because this software has cross-platform functionality on both desktop computers and handheld devices. The database is hosted online, and the rating forms can therefore also be accessed through most modern web browsers. Cross-platform digital assessment forms were developed for the rating of surgical skills. The database platform used in this study was reasonably priced, intuitive for the user, and flexible. The forms have been provided online as free downloads that may serve as the basis for further development or as inspiration for future efforts. In conclusion, digital assessment forms can be used for the structured rating of surgical skills and have the potential to be especially useful in complex assessment situations with multiple raters, repeated assessments in various times and locations, and situations requiring substantial subsequent data processing or complex score calculations.

  9. Experimental evaluation of new NEU cores in the UVAR

    Energy Technology Data Exchange (ETDEWEB)

    Farrar, P.; Hosticka, B.; Krause, D.; Mulder, R.; Rydin, R. [Univ. of Virginia, Charlottesville, VA (United States)

    1997-08-01

    The University of Virginia began working on converting the UVAR reactor to LEU fuel in the Spring of 1986. The Safety Analysis Report was completed and submitted to the NRC in late 1989. After review, the DOE order to manufacture LEU fuel was placed at B&W in March 1992, and the new fuel was received in January 1994. The 4-by-4 fully-graphite-reflected LEU-1 core went critical on April 20, 1994, and the 4-by-5 partially-graphite-reflected operational LEU-2 core went critical on April 29. Full power was achieved on May 12, 1994. Both cores behaved very much as originally predicted. All of the old HEU fuel has been shipped to Savannah River.

  10. INTERFEROMETRIC OBSERVATIONS OF NITROGEN-BEARING MOLECULAR SPECIES IN THE STAR-FORMING CORE AHEAD OF HH 80N

    Energy Technology Data Exchange (ETDEWEB)

    Masqué, Josep M.; Estalella, Robert [Departament d' Astronomia i Meteorologia, Universitat de Barcelona, Martí i Franquès 1, E-08028 Barcelona, Catalunya (Spain); Girart, Josep M. [Institut de Ciències de l' Espai (CSIC-IEEC), Campus UAB, Facultat de Ciències, Torre C5 - parell 2, E-08193 Bellaterra, Catalunya (Spain); Anglada, Guillem; Osorio, Mayra [Instituto de Astrofísica de Andalucía, CSIC, Camino Bajo de Huétor 50, E-18008 Granada (Spain); Beltrán, Maria T. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy)

    2013-10-10

    We present Very Large Array NH{sub 3} and Plateau de Bure Interferometer NH{sub 2}D and HN{sup 13}C observations of the star-forming core ahead of HH 80N, the optically obscured northern counterpart of the Herbig-Haro objects HH 80/81. The main goal is to determine the kinematical information of the high density regions of the core (n ∼> 10{sup 5} cm{sup –3}) missed in previous works due to the depletion of the species observed (e.g., CS). The obtained maps show different kinematical signatures between the eastern and western parts of the core, suggesting a possible dynamical interaction of the core with the HH 80/81/80N outflow. The analysis of the position-velocity (P-V) plots of these species rules out a previous interpretation of having a molecular ring-like structure with a radius of 6 × 10{sup 4} AU traced by CS infalling onto a central protostar found in the core (IRS1). A high degree of NH{sub 3} deuteration, with respect to the central part of the core harboring IRS1, is derived in the eastern part, where a dust condensation (SE) is located. This deuteration trend of NH{sub 3} suggests that SE is in a pre-stellar evolutionary stage, earlier than that of IRS1. Since SE is the closest condensation to the HH 80N/81/80N outflow, in a case of outflow-core dynamical interaction, it should be perturbed first and be the most evolved condensation in the core. Therefore, the derived evolutionary sequence for SE and IRS1 makes outflow triggered star formation on IRS1 unlikely.

  11. Isomorphic coalescence of aster cores formed in vitro from microtubules and kinesin motors

    Science.gov (United States)

    Kim, K.; Sikora, A.; Nakazawa, H.; Umetsu, M.; Hwang, W.; Teizer, W.

    2016-10-01

    We report fluorescence microscopy studies of the formation of aster-like structures emerging from a cellular element-based active system and a novel analysis of the aster condensation. The system consists of rhodamine labeled microtubules which are dynamically coupled by functionalized kinesin motor proteins cross-linked via streptavidin-coated quantum dots (QDs). The aster-shaped objects contain core structures. The cores are aggregates of the QD-motor protein complexes, and result from the dynamic condensation of sub-clusters that are connected to each other randomly. The structural specificity of the aster core reflects a configuration of the initial connectivity between sub-clusters. Detailed image analysis allows us to extract a novel correlation between the condensation speed and the sub-cluster separation. The size of the core is scaled down during the condensation process, following a power law dependence on the distance between sub-clusters. The exponent of the power law is close to two, as expected from a geometric model. This single exponent common to all the contractile lines implies that there exists a time regime during which an isomorphic contraction of the aster core continues during the condensation process. We analyze the observed contraction by using a model system with potential applicability in a wide range of emergent phenomena in randomly coupled active networks, which are prevalent in the cellular environment.

  12. Assessment on Evaluating Parameters of Rice Core Collections Constructed by Genotypic Values and Molecular Marker Information

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Eleven evaluating parameters for rice core collection were assessed based on genotypic values and molecular marker information. Monte Carlo simulation combined with mixed linear model was used to eliminate the interference from environment in order to draw more reliable results. The coincidence rate of range (CR) was the optimal parameter. Mean Simpson index (MD), mean Shannon-Weaver index of genetic diversity (M1) and mean polymorphism information content (MPIC) were important evaluating parameters. The variable rate of coefficient of variation (VR) could act as an important reference parameter for evaluating the variation degree of core collection. Percentage of polymorphic loci (p) could be used as a determination parameter for the size of core collection. Mean difference percentage (MD) was a determination parameter for the reliability judgment of core collection. The effective evaluating parameters for core collection selected in the research could be used as criteria for sampling percentage in different plant germplasm populations.

  13. DNC/HNC and N2D+/N2H+ ratios in high-mass star-forming cores

    Science.gov (United States)

    Fontani, F.; Sakai, T.; Furuya, K.; Sakai, N.; Aikawa, Y.; Yamamoto, S.

    2014-05-01

    Chemical models predict that the deuterated fraction (the column density ratio between a molecule containing D and its counterpart containing H) of N2H+, Dfrac(N2H+), high in massive pre-protostellar cores, is expected to rapidly drop by an order of magnitude after the protostar birth, while that of HNC, Dfrac(HNC), remains constant for much longer. We tested these predictions by deriving Dfrac(HNC) in 22 high-mass star-forming cores divided in three different evolutionary stages, from high-mass starless core candidates (HMSCs, eight) to high-mass protostellar objects (HMPOs, seven) to ultracompact H II regions (UCHIIs, seven). For all of them, Dfrac(N2H+) was already determined through IRAM 30 m Telescope observations, which confirmed the theoretical rapid decrease of Dfrac(N2H+) after protostar birth. Therefore, our comparative study is not affected by biases introduced by the source selection. We have found average Dfrac(HNC) of 0.012, 0.009 and 0.008 in HMSCs, HMPOs and UCHIIs, respectively, with no statistically significant differences among the three evolutionary groups. These findings confirm the predictions of the chemical models, and indicate that large values of Dfrac(N2H+) are more suitable than large values of Dfrac(HNC) to identify cores on the verge of forming high-mass stars, likewise what was found in the low-mass regime.

  14. Core self-evaluations and job performance: the role of the perceived work environment.

    Science.gov (United States)

    Kacmar, K Michele; Collins, Brian J; Harris, Kenneth J; Judge, Timothy A

    2009-11-01

    Using trait activation theory as a framework, the authors examined the moderating role of two situational variables-perceptions of organizational politics and perceptions of leader effectiveness-on the relationship between core self-evaluations and job performance. Results from two samples (N = 137 and N = 226) indicate that employee perceptions of their work environment moderated the relationship between their core self-evaluations and supervisor ratings of their performance. In particular, those with higher core self-evaluations received higher performance ratings in environments perceived as favorable than in environments perceived as unfavorable.

  15. Redox Biology Course Evaluation Form | Center for Cancer Research

    Science.gov (United States)

    To improve the Redox Biology (RB) course in future years, we would appreciate your feedback by completing this course evaluation. Please score the course elements as poor, fair, average, good or excellent. Please type any comments that you have in response to the questions at the bottom of the form. Remember to include your name as you wish it to appear on the certificate. Thank you for your feedback.

  16. TADPOL: A 1.3 mm Survey of Dust Polarization in Star-forming Cores and Regions

    OpenAIRE

    Hull, Charles L. H.; Plambeck, Richard L.; Kwon, Woojin; Bower, Geoffrey C.; Carpenter, John M.; Crutcher, Richard M.; Fiege, Jason D.; Franzmann, Erica; Hakobian, Nicholas S.; Heiles, Carl; Houde, Martin; Hughes, A. Meredith; Lamb, James W.; Looney, Leslie W.; Marrone, Daniel P.

    2014-01-01

    We present λ 1.3 mm Combined Array for Research in Millimeter-wave Astronomy observations of dust polarization toward 30 star-forming cores and eight star-forming regions from the TADPOL survey. We show maps of all sources, and compare the ~2".5 resolution TADPOL maps with ~20" resolution polarization maps from single-dish submillimeter telescopes. Here we do not attempt to interpret the detailed B-field morphology of each object. Rather, we use average B-field orientations to derive conclusi...

  17. Reactivity characteristics evaluations of the initial core of MONJU

    Energy Technology Data Exchange (ETDEWEB)

    Sawada, Shusaku; Suzuki, Takayuki; Okimoto, Yutaka; Sasaki, Kenji; Deshimaru, Takehide [Power Reactor and Nuclear Fuel Development Corp., Tsuruga, Fukui (Japan). Monju Construction Office; Nakashima, Fumiaki

    1996-09-01

    This paper describes measured results and their analysis results of the reactivity characteristics of the initial core of MONJU, specifically, those of the control and back-up rod reactivity worth, the fixed absorber reactivity worth, the fuel sub-assembly reactivity worth and the coolant reactivity worth. Those were measured during the MONJU reactor physics test carried out from May 1994 through November 1994. Since the measured values were reproduced quite well by calculations, we confirmed the applicability of our calculational method to the reactivity worth characteristics analysis of MONJU. (author)

  18. A distance limited sample of massive star forming cores from the RMS survey

    CERN Document Server

    Maud, L T; Moore, T J T; Mottram, J C; Urquhart, J S; Cicchini, A

    2015-01-01

    We analyse C$^{18}$O ($J=3-$2) data from a sample of 99 infrared-bright massive young stellar objects (MYSOs) and compact HII regions that were identified as potential molecular-outflow sources in the Red MSX source (RMS) survey. We extract a distance limited (D $<$ 6 kpc) sample shown to be representative of star formation covering the transition between the source types. At the spatial resolution probed, Larson-like relationships are found for these cores, though the alternative explanation, that Larson's relations arise where surface-density-limited samples are considered, is also consistent with our data. There are no significant differences found between source properties for the MYSOs and HII regions, suggesting that the core properties are established prior to the formation of massive stars, which subsequently have little impact at the later evolutionary stages investigated. There is a strong correlation between dust-continuum and C$^{18}$O-gas masses, supporting the interpretation that both trace t...

  19. Development, evaluation, and utility of a peer evaluation form for online teaching.

    Science.gov (United States)

    Gaskamp, Carol D; Kintner, Eileen

    2014-01-01

    Formative assessment of teaching by peers is an important component of quality improvement for educators. Teaching portfolios submitted for promotion and tenure are expected to include peer evaluations. Faculty resources designed for peer evaluation of classroom teaching are often inadequate for evaluating online teaching. The authors describe development, evaluation, and utility of a new peer evaluation form for formative assessment of online teaching deemed relevant, sound, feasible, and beneficial.

  20. Differential influence of instruments in nuclear core activity evaluation by data assimilation

    Energy Technology Data Exchange (ETDEWEB)

    Bouriquet, Bertrand, E-mail: bertrand.bouriquet@cerfacs.f [Sciences de l' Univers au CERFACS, URA CERFACS/CNRS No 1875, 42 avenue Gaspard Coriolis, F-31057 Toulouse Cedex 01 (France); Argaud, Jean-Philippe [Sciences de l' Univers au CERFACS, URA CERFACS/CNRS No 1875, 42 avenue Gaspard Coriolis, F-31057 Toulouse Cedex 01 (France); Electricite de France, 1 avenue du General de Gaulle, F-92141 Clamart Cedex (France); Erhard, Patrick [Electricite de France, 1 avenue du General de Gaulle, F-92141 Clamart Cedex (France); Massart, Sebastien [Sciences de l' Univers au CERFACS, URA CERFACS/CNRS No 1875, 42 avenue Gaspard Coriolis, F-31057 Toulouse Cedex 01 (France); Poncot, Angelique [Electricite de France, 1 avenue du General de Gaulle, F-92141 Clamart Cedex (France); Ricci, Sophie [Sciences de l' Univers au CERFACS, URA CERFACS/CNRS No 1875, 42 avenue Gaspard Coriolis, F-31057 Toulouse Cedex 01 (France); Thual, Olivier [Sciences de l' Univers au CERFACS, URA CERFACS/CNRS No 1875, 42 avenue Gaspard Coriolis, F-31057 Toulouse Cedex 01 (France); Universite de Toulouse, INPT, UPS, IMFT, Allee Camille Soula, F-31400 Toulouse (France)

    2011-01-21

    The global neutronic activity fields of a nuclear core can be reconstructed using data assimilation. Indeed, data assimilation allows to combine both measurements from instruments and information from a model, to evaluate the best possible neutronic activity within the core. We present and apply a specific procedure which evaluates the influence of measures by adding or removing instruments in a given measurement network (possibly empty). The study of various network configurations for the instruments in the nuclear core establishes that the influence of the instruments depends both on the independent instrumentation location and on the chosen network.

  1. Research on the Core Competitive Power Elements Evaluation System of Green Hotel

    Directory of Open Access Journals (Sweden)

    Hui Liang

    2013-12-01

    Full Text Available Green hotel is a new type of hospitality industry development model based on the concept of circular economy and sustainable development. This paper makes an analysis and evaluation of the elements of green hotel core competence, on this basis, constructs the Green Hotel core competitive evaluation index system.The construction of the system is conducive to understand the green hotel’s own competitive advantage objectively, and explore ways to enhance its core competitiveness, providing objective basis for sustainable development of China's Hotel industry.

  2. The relationship between core self-evaluations, views of god, and intrinsic/extrinsic religious motivation.

    Science.gov (United States)

    Smither, James W; Walker, Alan G

    2015-04-01

    Core self-evaluations refer to a higher-order construct that subsumes four well-established traits in the personality literature: self-esteem, generalized self-efficacy, (low) neuroticism, and (internal) locus of control. Studies that have examined the relationship between various measures of religiosity and individual components of core self-evaluations show no clear pattern of relationships. The absence of a clear pattern may be due to the failure of most previous studies in this area to use theory to guide research. Therefore, theories related to core self-evaluations, religious motivation, and views of God were used to develop and test four hypotheses. 220 adults completed measures of four religious attitudes (intrinsic religious motivation, extrinsic religious motivation, viewing God as loving, and viewing God as punitive), general religiosity, and core self-evaluations, separated by 6 weeks (with the order of measures counterbalanced). Multivariate multiple regression, controlling for general religiosity, showed that core self-evaluations were positively related to viewing God as loving, negatively related to viewing God as punitive, and negatively related to extrinsic religious motivation. The hypothesis that core self-evaluations would be positively related to intrinsic religious motivation was not supported.

  3. Developing a Framework for Qualitative Evaluation of Urban Interventions in Iranian Historical Cores

    Directory of Open Access Journals (Sweden)

    Azadeh Arjomand Kermani

    2016-06-01

    Full Text Available Iranian historic city cores are important parts of modern cities because of their valuable monuments and morphology but are also significant because of their population density, location and the major governmental functions they house. Since 1920, modernisation policies and urban development trends in Iran have justified spatial transformation and redevelopment and the demolition and destruction of traditional urban fabrics as a way to provide contemporary requirements and hygiene improvements for the residents. As the UNESCO recommendation on the Historic Urban Landscape argues, historic urban cores can only sustain their role in the daily life of the city by getting prepared for and participating in this transformation process.Disagreement over the value of historic urban cores on the one hand and inevitable modification of urban areas in a developing country like Iran on the other, creates a problematic condition for the preservation of the historic environment. The Valletta Principles for the Safeguarding and Management of Historic Cities, Towns and Urban Areas states that historic towns and urban areas require an integrated approach including their “protection, conservation, enhancement and management as well as their coherent development and their harmonious adaptation to contemporary life”. In order to support the process of reaching a balance between these spatial targets in Iran, this research discusses the relation between urban transformation projects and their heritage context. In doing so it connects international literature on urban quality and traditional Iranian urban forms to contemporary Iranian urban design practice.To achieve this integration between urban heritage and spatial development, a framework of quality attributes has been developed to evaluate urban interventions in a heritage context. The three main pillars of this framework have been extracted from and inspired by international literature and guidelines. Place

  4. The Photoionization of a Star-Forming Core in the Trifid Nebula

    CERN Document Server

    Le Floc'h, B; Rodríguez, L F; Miville-Deschênes, M A; Cesarsky, D; Heras, A

    2002-01-01

    We have carried out a comprehensive multiwavelength study of Bright-Rimmed Globule TC2 in the Trifid Nebula using the IRAM~30m telescope, the VLA centimeter array and the Infrared Space Observatory (ISO). TC2 is one of the very few globules to exhibit signs of active ongoing star formation while being photoevaporated. The study of the kinematics shows that TC2 is currently undergoing an implosion driven by the ionization field. The physical structure of the molecular core, the Photon-Dominated Region and the ionization front are characterized. The properties of the PDR are in good agreement with some recent PDR models. The molecular emission suggests that the star formation process was probably initiated a few 0.1 Myr ago, in the large burst which led to the formation of the nebula. The impact of photoionization on the star formation process appears limited.

  5. Herschel/HIFI observations of spectrally resolved methylidyne signatures toward the high-mass star forming core NGC6334I

    CERN Document Server

    van der Wiel, M H D; Lis, D C; Bergin, E A; Comito, C; Emprechtinger, M; Schilke, P; Caux, E; Ceccarelli, C; Baudry, A; Goldsmith, P F; Herbst, E; Langer, W; Lord, S; Neufeld, D; Pearson, J; Philips, T; Rolffs, R; Yorke, H; Bacmann, A; Benedettini, M; Blake, G A; Boogert, A; Bottinelli, S; Cabrit, S; Caselli, P; Castets, A; Cernicharo, J; Codella, C; Coutens, A; Crimier, N; Demyk, K; Dominik, C; Encrenaz, P; Falgarone, E; Fuente, A; Gerin, M; Helmich, F; Hennebelle, P; Henning, T; Hily-Blant, P; Jacq, T; Kahane, C; Kama, M; Klotz, A; Lefloch, B; Lorenzani, A; Maret, S; Melnick, G; Nisini, B; Pacheco, S; Pagani, L; Parise, B; Salez, M; Saraceno, P; Schuster, K; Tielens, A G G M; Vastel, C; Viti, S; Wakelam, V; Walters, A; Wyrowski, F; Edwards, K; Zmuidzinas, J; Morris, P; Samoska, L A; Teyssier, D

    2010-01-01

    In contrast to extensively studied dense star forming cores, little is known about diffuse gas surrounding star forming regions. We aim to study molecular gas in the high-mass star forming region NGC6334I, including diffuse, quiescent components which are inconspicuous in widely used molecular tracers such as CO. We present Herschel/HIFI observations of CH toward NGC6334I observed as part of the CHESS Key Program. HIFI resolves the hyperfine components of its J=3/2-1/2 transition, observed in emission as well as in absorption. The CH emission appears close to the systemic velocity of NGC6334I, while a linewidth of 3 km/s is smaller than previously observed in dense gas tracers such as NH3 and SiO. The CH abundance in the hot core is 7 10^-11, two to three orders of magnitude lower than in diffuse clouds. While other studies find distinct outflows in, e.g., CO and H2O toward NGC6334I, we do not detect outflow signatures in CH. To explain the absorption signatures, at least two absorbing components are needed a...

  6. A core-item reviewer evaluation (CoRE) system for manuscript peer review.

    Science.gov (United States)

    Onitilo, Adedayo A; Engel, Jessica M; Salzman-Scott, Sherry A; Stankowski, Rachel V; Doi, Suhail A R

    2014-01-01

    Manuscript peer review is essential for ensuring accountability to all involved in the publication process, including authors, journals, and readers. Lack of consensus regarding what constitutes an accountable manuscript peer review process has resulted in varying practices from one journal to the next. Currently, reviewers are asked to make global judgments about various aspects of a paper for review irrespective of whether guided by a review checklist or not, and several studies have documented gross disagreement between reviewers of the same manuscript. We have previously proposed that the solution may be to direct reviewers to concrete items that do not require global judgments but rather provide a specific choice, along with referee justification for such choices. This study evaluated use of such a system via an international survey of health care professionals who had recently reviewed a health care--related manuscript. Results suggest that use of such a peer review system by reviewers does indeed improve interreviewer agreement, and thus, has the potential to support more consistent and effective peer review, if introduced into journal processes for peer review.

  7. Nanostructures formed in pure quartz glass under irradiation in the reactor core

    Science.gov (United States)

    Ibragimova, E. M.; Mussaeva, M. A.; Kalanov, M. U.

    2014-04-01

    Optical spectroscopy and X-ray diffraction techniques were used for studying nanoscale particles grown in pure SiO2 glass under irradiation with fast neutron fluencies within 6×1016-5·1019 cm-2 and gamma-quanta ~1.8×1020 cm-2 in the reactor core in water. The neutron irradiation results in destroying of the initial α- and β-quartz mesoscopic order of 1.7 and 1.2 nm sizes and growing of cristobalite and tridymite nanocrystals of 16 and 8 nm sizes in the thermal peaks of displacements reapectively. The point defects (oxygen deficient E‧s, E'1, E'2 and non-bridging oxygen centers) induced by the γ-irradiation are accumulated in the nanocrystals shell of 0.65-0.85 nm thickness. Interaction of close point defects at the nanocrystal-glass interface causes the splitting of optical absorption bands into the intensive (D~2-4) resonances characteristic for local interband electron transitions, having the width of 10-15 nm close to the nanocrystals' sizes and the energy depending on their structure.

  8. TiO2@C Core-Shell Nanoparticles Formed by Polymeric Nano-Encapsulation

    Directory of Open Access Journals (Sweden)

    Mitra eVasei

    2014-07-01

    Full Text Available TiO2 semiconducting nanoparticles are known to be photocatalysts of moderate activity due to their high band-gap and high rate of electron-hole recombination. The formation of a shell of carbon around the core of TiO2, i.e. the formation of TiO2@C nanoparticles, is believed to partly alleviate these problems. It is usually achieved by a hydrothermal treatment in a presence of a sugar derivative. We present here a novel method for the formation of highly uniform C shell around TiO2 nanoparticles. For this purpose, TiO2 nanoparticles were dispersed in water using an oligomeric dispersant prepared by Reversible Addition-Fragmentation chain Transfer (RAFT polymerization. Then the nanoparticles were engaged into an emulsion polymerization of acrylonitrile, resulting in the formation of a shell of polyacrylonitrile (PAN around each TiO2 nanoparticles. Upon pyrolisis, the PAN was transformed into carbon, resulting in the formation of TiO2@C nanoparticles. The structure of the resulting particles was elucidated by X-Ray diffraction, FTIR, UV-VIS and Raman spectroscopy as well as TEM microscopy. Preliminary results about the use of the TiO2@C particles as photocatalysts for the splitting of water are presented. They indicate that the presence of the C shell is responsible for a significant enhancement of the photocurrent.

  9. TiO2@C core-shell nanoparticles formed by polymeric nano-encapsulation.

    Science.gov (United States)

    Vasei, Mitra; Das, Paramita; Cherfouth, Hayet; Marsan, Benoît; Claverie, Jerome P

    2014-01-01

    TiO2 semiconducting nanoparticles are known to be photocatalysts of moderate activity due to their high band-gap and high rate of electron-hole recombination. The formation of a shell of carbon around the core of TiO2, i.e., the formation of TiO2@C nanoparticles, is believed to partly alleviate these problems. It is usually achieved by a hydrothermal treatment in a presence of a sugar derivative. We present here a novel method for the formation of highly uniform C shell around TiO2 nanoparticles. For this purpose, TiO2 nanoparticles were dispersed in water using an oligomeric dispersant prepared by Reversible Addition-Fragmentation chain Transfer (RAFT) polymerization. Then the nanoparticles were engaged into an emulsion polymerization of acrylonitrile, resulting in the formation of a shell of polyacrylonitrile (PAN) around each TiO2 nanoparticles. Upon pyrolysis, the PAN was transformed into carbon, resulting in the formation of TiO2@C nanoparticles. The structure of the resulting particles was elucidated by X-Ray diffraction, FTIR, UV-VIS and Raman spectroscopy as well as TEM microscopy. Preliminary results about the use of the TiO2@C particles as photocatalysts for the splitting of water are presented. They indicate that the presence of the C shell is responsible for a significant enhancement of the photocurrent.

  10. Evaluation of AGNI SFR core neutronics parameters with VESTA and ERANOS

    Science.gov (United States)

    Ecrabet, Fabrice; Haeck, Wim; Chaitanya Tadepalli, Sai

    2014-06-01

    This paper presents the calculation of core neutronics parameters for so called AGNI Sodium Fast Reactor (SFR) model performed with ERANOS code and Monte Carlo depletion interface software VESTA. The AGNI core has been developed at IRSN for its own R&D needs, i.e. to test performance of calculation codes for safety assessment of a generation IV SFR project. The ERANOS code is used as reference code for SFR core calculations at IRSN. In this work, VESTA calculations have been performed and compared with corresponding ERANOS results. These calculations have a double purpose: mastering the use of tools for the evaluation of SFR core static neutronics parameters and validate the use of VESTA for SFR cores.

  11. Evaluating the MBTI® Form M in a South African context

    Directory of Open Access Journals (Sweden)

    Casper J.J. van Zyl

    2012-09-01

    Full Text Available Orientation: Psychological instruments require continued refinement, updating andevaluation.Research purpose: To investigate the reliability, validity and differential item functioning ofthe MBTI® Form M across groups in South Africa using Classical Test Theory (CTT and ItemResponse Theory (IRT methods.Motivation for the study: To add to the continual research and improvement of the MBTI®Form M through the investigation of its psychometric properties across groups in South Africa.Research design, approach and method: This study falls within the quantitative researchparadigm. Classical test theory methods and Rasch analysis were used to evaluate thefunctioning of the MBTI Form M across gender and ethnic groups. A cross-sectional study wascompleted consisting of 10 705 South African respondents.Main findings: Excellent reliability was found for the instrument across groups in thesample. Good evidence for construct validity was found using exploratory factor analysis andconfirmatory factor analysis. Some evidence for uniform bias was found across ethnic andgender groups and a few items reflected non-uniform DIF across gender groups only. Theeffect of uniform and non-uniform DIF did not appear to have major practical implications forthe interpretation of the scales.Practical/managerial implications: The results provided evidence that supports thepsychometric validity of the MBTI instrument in the South African context.Contribution/value-add: This study is the largest study to date regarding the psychometricfunctioning of the MBTI instrument in South Africa. It contributes to the evolution of theinstrument in line

  12. A Simple Method for Forming Hybrid Core-Shell Nanoparticles Suspended in Water

    Directory of Open Access Journals (Sweden)

    Jean-Christophe Daigle

    2008-01-01

    addition fragmentation chain transfer (RAFT polymerization as dispersant. Then, the resulting dispersion is engaged in a radical emulsion polymerization process whereby a hydrophobic organic monomer (styrene and butyl acrylate is polymerized to form the shell of the hybrid nanoparticle. This method is extremely versatile, allowing the preparation of a variety of nanocomposites with metal oxides (alumina, rutile, anatase, barium titanate, zirconia, copper oxide, metals (Mo, Zn, and even inorganic nitrides (Si3N4.

  13. DNC/HNC and N2D+/N2H+ ratios in high-mass star forming cores

    CERN Document Server

    Fontani, F; Furuya, K; Sakai, N; Aikawa, Y; Yamamoto, S

    2014-01-01

    Chemical models predict that the deuterated fraction (the column density ratio between a molecule containing D and its counterpart containing H) of N2H+, Dfrac(N2H+), is high in massive pre-protostellar cores and rapidly drops of an order of magnitude after the protostar birth, while that of HNC, Dfrac(HNC), remains constant for much longer. We tested these predictions by deriving Dfrac(HNC) in 22 high-mass star forming cores divided in three different evolutionary stages, from high-mass starless core candidates (HMSCs, 8) to high-mass protostellar objects (HMPOs, 7) to Ultracompact HII regions (UCHIIs, 7). For all of them, Dfrac (N2H+) was already determined through IRAM-30m Telescope observations, which confirmed the theoretical rapid decrease of Dfrac(N2H+) after protostar birth (Fontani et al. 2011). Therefore our comparative study is not affected by biases introduced by the source selection. We have found average Dfrac(HNC) of 0.012, 0.009 and 0.008 in HMSCs, HMPOs and UCHIIs, respectively, with no stati...

  14. Far-ultraviolet morphology of star-forming filaments in cool core brightest cluster galaxies

    Science.gov (United States)

    Tremblay, G. R.; O'Dea, C. P.; Baum, S. A.; Mittal, R.; McDonald, M. A.; Combes, F.; Li, Y.; McNamara, B. R.; Bremer, M. N.; Clarke, T. E.; Donahue, M.; Edge, A. C.; Fabian, A. C.; Hamer, S. L.; Hogan, M. T.; Oonk, J. B. R.; Quillen, A. C.; Sanders, J. S.; Salomé, P.; Voit, G. M.

    2015-08-01

    We present a multiwavelength morphological analysis of star-forming clouds and filaments in the central (≲50 kpc) regions of 16 low-redshift (z atlas of star formation locales relative to the ambient hot (˜107-8 K) and warm ionized (˜104 K) gas phases, as well as the old stellar population and radio-bright active galactic nucleus (AGN) outflows. Nearly half of the sample possesses kpc-scale filaments that, in projection, extend towards and around radio lobes and/or X-ray cavities. These filaments may have been uplifted by the propagating jet or buoyant X-ray bubble, or may have formed in situ by cloud collapse at the interface of a radio lobe or rapid cooling in a cavity's compressed shell. The morphological diversity of nearly the entire FUV sample is reproduced by recent hydrodynamical simulations in which the AGN powers a self-regulating rain of thermally unstable star-forming clouds that precipitate from the hot atmosphere. In this model, precipitation triggers where the cooling-to-free-fall time ratio is tcool/tff ˜ 10. This condition is roughly met at the maximal projected FUV radius for more than half of our sample, and clustering about this ratio is stronger for sources with higher star formation rates.

  15. Parallel Likelihood Function Evaluation on Heterogeneous Many-core Systems

    CERN Document Server

    Jarp, Sverre; Leduc, Julien; Nowak, Andrzej; Sneen Lindal, Yngve

    2011-01-01

    This paper describes a parallel implementation that allows the evaluations of the likelihood function for data analysis methods to run cooperatively on heterogeneous computational devices (i.e. CPU and GPU) belonging to a single computational node. The implementation is able to split and balance the workload needed for the evaluation of the likelihood function in corresponding sub-workloads to be executed in parallel on each computational device. The CPU parallelization is implemented using OpenMP, while the GPU implementation is based on OpenCL. The comparison of the performance of these implementations for different configurations and different hardware systems are reported. Tests are based on a real data analysis carried out in the high energy physics community.

  16. An in vitro comparative evaluation of physical properties of four different types of core materials

    Directory of Open Access Journals (Sweden)

    Antara Agrawal

    2014-01-01

    Full Text Available Introduction: Compressive and tensile stresses of core materials are important properties because cores usually replace a large bulk of tooth structure and must resist multidirectional masticatory forces for many years. Material and Methods: The present study was undertaken to find out the best core build up material with respect to their physical properties among resin-based composites. Individual compressive, tensile, and flexural strength of fiber-reinforced dual cure resin core build up material, silorane-based composite resin, and dual curing composite for core build up with silver amalgam core was used as control were evaluated and compared using universal testing machine. Data were statistical analysed using Kruskal-Wallis test to determine whether statistically significant differences (P < 0.05 existed among core materials. Both dual cure composite materials with nanofillers were found superior to amalgam core. The silorane-based material showed the highest flexural strength, but other mechanical properties were inferior to dual cure composite materials with nanofillers.

  17. DEUTERIUM BURNING IN MASSIVE GIANT PLANETS AND LOW-MASS BROWN DWARFS FORMED BY CORE-NUCLEATED ACCRETION

    Energy Technology Data Exchange (ETDEWEB)

    Bodenheimer, Peter [UCO/Lick Observatory, Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); D' Angelo, Gennaro; Lissauer, Jack J. [Space Science and Astrobiology Division, NASA-Ames Research Center, Moffett Field, CA 94035 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Saumon, Didier, E-mail: peter@ucolick.org, E-mail: gennaro.dangelo@nasa.gov, E-mail: Jack.J.Lissauer@nasa.gov, E-mail: jfortney@ucolick.org, E-mail: dsaumon@lanl.gov [Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM 87545 (United States)

    2013-06-20

    Using detailed numerical simulations, we study the formation of bodies near the deuterium-burning limit according to the core-nucleated giant planet accretion scenario. The objects, with heavy-element cores in the range 5-30 M{sub Circled-Plus }, are assumed to accrete gas up to final masses of 10-15 Jupiter masses (M{sub Jup}). After the formation process, which lasts 1-5 Myr and which ends with a ''cold-start'', low-entropy configuration, the bodies evolve at constant mass up to an age of several Gyr. Deuterium burning via proton capture is included in the calculation, and we determined the mass, M{sub 50}, above which more than 50% of the initial deuterium is burned. This often-quoted borderline between giant planets and brown dwarfs is found to depend only slightly on parameters, such as core mass, stellar mass, formation location, solid surface density in the protoplanetary disk, disk viscosity, and dust opacity. The values for M{sub 50} fall in the range 11.6-13.6 M{sub Jup}, in agreement with previous determinations that do not take the formation process into account. For a given opacity law during the formation process, objects with higher core masses form more quickly. The result is higher entropy in the envelope at the completion of accretion, yielding lower values of M{sub 50}. For masses above M{sub 50}, during the deuterium-burning phase, objects expand and increase in luminosity by one to three orders of magnitude. Evolutionary tracks in the luminosity versus time diagram are compared with the observed position of the companion to Beta Pictoris.

  18. Outcome-based residency education: teaching and evaluating the core competencies in plastic surgery.

    Science.gov (United States)

    Bancroft, Gregory N; Basu, C Bob; Leong, Mimi; Mateo, Carol; Hollier, Larry H; Stal, Samuel

    2008-06-01

    Through its oversight of residency education in the United States, the Accreditation Council for Graduate Medical Education has mandated new structural changes in resident education with its newly created core competencies and an emphasis on outcomes-based education. These core competencies represent the central areas in which the Accreditation Council for Graduate Medical Education believes a plastic surgery resident should receive adequate and appropriate education and training. In addition, as part of this outcomes-based education, residents are to be evaluated on their level of mastery in these core competencies. Increasingly, the Accreditation Council for Graduate Medical Education will assess the ability of residency programs to integrate the teaching and evaluating of the core competencies in their accreditation process of plastic surgery residency programs. This shift in residency evaluation initiated by the Outcomes Project by the Accreditation Council for Graduate Medical Education will have a significant impact in how plastic surgery residents are taught and, as importantly, evaluated in the coming years. The objectives of this work were as follows: (1) to outline the different methods available to foster a core competency-based plastic surgery training curriculum and (2) to serve as a primer to help both full-time academic and clinical faculty to further develop their curriculum to successfully teach and constructively evaluate their residents in the core competencies in accordance with the Accreditation Council for Graduate Medical Education guidelines. At the conclusion of this review, the reader should have a better understanding of what is necessary to formulate and help foster a plastic surgery core competency curriculum, particularly with an emphasis on the contemporary methods used for outcomes evaluations.

  19. Job Characteristics, Core Self-Evaluations, and Job Satisfaction: What's Age Got to Do with It?

    Science.gov (United States)

    Besen, Elyssa; Matz-Costa, Christina; Brown, Melissa; Smyer, Michael A.; Pitt-Catsouphes, Martha

    2013-01-01

    There is a well-established relationship between age and job satisfaction. To date, there is little research about how many well-known predictors of job satisfaction, specifically job characteristics and core self-evaluations, may vary with age. Using a multi-worksite sample of 1,873 employed adults aged 17 to 81, this study evaluated the extent…

  20. Toolkit for Evaluating Alignment of Instructional and Assessment Materials to the Common Core State Standards

    Science.gov (United States)

    Achieve, Inc., 2014

    2014-01-01

    In joint partnership, Achieve, The Council of Chief State School Officers, and Student Achievement Partners have developed a Toolkit for Evaluating the Alignment of Instructional and Assessment Materials to the Common Core State Standards. The Toolkit is a set of interrelated, freely available instruments for evaluating alignment to the CCSS; each…

  1. Job Characteristics, Core Self-Evaluations, and Job Satisfaction: What's Age Got to Do with It?

    Science.gov (United States)

    Besen, Elyssa; Matz-Costa, Christina; Brown, Melissa; Smyer, Michael A.; Pitt-Catsouphes, Martha

    2013-01-01

    There is a well-established relationship between age and job satisfaction. To date, there is little research about how many well-known predictors of job satisfaction, specifically job characteristics and core self-evaluations, may vary with age. Using a multi-worksite sample of 1,873 employed adults aged 17 to 81, this study evaluated the extent…

  2. The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis.

    Science.gov (United States)

    McGlinchey, Ryan P; Shewmaker, Frank; McPhie, Peter; Monterroso, Begoña; Thurber, Kent; Wickner, Reed B

    2009-08-18

    Pmel17 is a melanocyte protein necessary for eumelanin deposition 1 in mammals and found in melanosomes in a filamentous form. The luminal part of human Pmel17 includes a region (RPT) with 10 copies of a partial repeat sequence, pt.e.gttp.qv., known to be essential in vivo for filament formation. We show that this RPT region readily forms amyloid in vitro, but only under the mildly acidic conditions typical of the lysosome-like melanosome lumen, and the filaments quickly become soluble at neutral pH. Under the same mildly acidic conditions, the Pmel filaments promote eumelanin formation. Electron diffraction, circular dichroism, and solid-state NMR studies of Pmel17 filaments show that the structure is rich in beta sheet. We suggest that RPT is the amyloid core domain of the Pmel17 filaments so critical for melanin formation.

  3. Observation of HCN hyperfine line anomalies towards low- and high-mass star-forming cores

    CERN Document Server

    Loughnane, R M; Thompson, M A; Lo, N; O'Dwyer, B; Cunningham, M R; 10.1111/j.1365-2966.2011.20121.x

    2013-01-01

    HCN is becoming a popular choice of molecule for studying star formation in both low- and high-mass regions and for other astrophysical sources from comets to high-redshift galaxies. However, a major and often overlooked difficulty with HCN is that it can exhibit non-local thermodynamic equilibrium (non-LTE) behaviour in its hyperfine line structure. Individual hyperfine lines can be strongly boosted or suppressed. In low-mass star-forming cloud observations, this could possibly lead to large errors in the calculation of opacity and excitation temperature, while in massive star-forming clouds, where the hyperfine lines are blended due to turbulent broadening, errors will arise in infall measurements that are based on the separation of the peaks in a self-absorbed profile. The underlying line shape cannot be known for certain if hyperfine anomalies are present. We present a first observational investigation of these anomalies across a range of conditions and transitions by carrying out a survey of low-mass sta...

  4. Far Ultraviolet Morphology of Star Forming Filaments in Cool Core Brightest Cluster Galaxies

    CERN Document Server

    Tremblay, Grant R; Baum, Stefi A; Mittal, Rupal; McDonald, Michael; Combes, Françoise; Li, Yuan; McNamara, Brian; Bremer, Malcolm N; Clarke, Tracy E; Donahue, Megan; Edge, Alastair C; Fabian, Andrew C; Hamer, Stephen L; Hogan, Michael T; Oonk, Raymond; Quillen, Alice C; Sanders, Jeremy S; Salomé, Philippe; Voit, G Mark

    2015-01-01

    We present a multiwavelength morphological analysis of star forming clouds and filaments in the central ($ 5$ \\Msol) stars reveals filamentary and clumpy morphologies, which we quantify by means of structural indices. The FUV data are compared with X-ray, Ly$\\alpha$, narrowband H$\\alpha$, broadband optical/IR, and radio maps, providing a high spatial resolution atlas of star formation locales relative to the ambient hot ($\\sim10^{7-8}$ K) and warm ionised ($\\sim 10^4$ K) gas phases, as well as the old stellar population and radio-bright AGN outflows. Nearly half of the sample possesses kpc-scale filaments that, in projection, extend toward and around radio lobes and/or X-ray cavities. These filaments may have been uplifted by the propagating jet or buoyant X-ray bubble, or may have formed {\\it in situ} by cloud collapse at the interface of a radio lobe or rapid cooling in a cavity's compressed shell. The morphological diversity of nearly the entire FUV sample is reproduced by recent hydrodynamical simulations...

  5. Core self-evaluations mediate the associations of dispositional optimism and life satisfaction.

    Science.gov (United States)

    Jiang, Wensheng; Li, Fei; Jiang, Haipeng; Yu, Lili; Liu, Wenbo; Li, Qiang; Zuo, Luning

    2014-01-01

    Positive traits, such as life satisfaction, optimism, and core self-evaluation (CSE), have garnered increasing attention from researchers and professionals. However, the trilateral relationship among them remains unclear. This study examines the effect of dispositional optimism on life satisfaction and primarily verified the mediator role of CSEs. Six hundred thirty college students from two general universities completed a questionnaire packet containing life orientation test-revised (LOT-R), core self-evaluations, and satisfaction with life scale. Confirmatory factor analysis (CFA) was conducted to assess the dimension of LOT-R. Bootstrap was used in structural equation modeling to analyze mediation effect. Results revealed that dispositional optimism and core self-evaluations were significantly correlated with life satisfaction. CFA identified the bidimensional structure of dispositional optimism. SEM indicated that core self-evaluations partially mediated the effect of dispositional optimism on life satisfaction. The final model also revealed significant paths from optimism and pessimism to life satisfaction through core-self evaluations. The findings extended prior studies and shed light on how dispositional optimism influences life satisfaction. This study provides valuable evidence on how to promote the life satisfaction of human beings in positive psychology. A further study can fully explore the relationship among them in multi-cultural follow-up studies.

  6. TADPOL: A 1.3 mm Survey of Dust Polarization in Star-forming Cores and Regions

    CERN Document Server

    Hull, Charles L H; Kwon, Woojin; Bower, Geoffrey C; Carpenter, John M; Crutcher, Richard M; Fiege, Jason D; Franzmann, Erica; Hakobian, Nicholas S; Heiles, Carl; Houde, Martin; Hughes, A Meredith; Lamb, James W; Looney, Leslie W; Marrone, Daniel P; Matthews, Brenda C; Pillai, Thushara; Pound, Marc W; Rahman, Nurur; Sandell, Göran; Stephens, Ian W; Tobin, John J; Vaillancourt, John E; Volgenau, N H; Wright, Melvyn C H

    2013-01-01

    We present results of 1.3 mm dust polarization observations toward 29 star-forming cores and 8 high-mass star-forming regions, mapped with ~2.5'' resolution at CARMA as part of the TADPOL survey. We discuss three main findings in this work: (1) A subset of the sources have consistent magnetic field orientations between the large scales measured by single-dish submillimeter telescopes (with ~20'' resolution) and the small scales measured by CARMA. Those same sources also tend to have higher fractional polarizations than the sources with inconsistent large-to-small-scale fields, possibly because there is less twisting of the B-fields to reduce the polarization fraction. This suggests that in at least some sources, the B-fields play a role in regulating the infall of material over many orders of magnitude, all the way down to ~1000AU protostellar envelope scales. (2) Even in the sources with consistent large-to-small-scale field orientations, the magnetic fields in the cores are misaligned with outflows from the...

  7. Heave Compensation Evaluation and Formation Strength Estimation from Drill String Acceleration Measurements While Coring

    Science.gov (United States)

    Guerin, G.; Goldberg, D.; Meltser, A.

    2001-05-01

    One of the recurring challenges in deep-sea drilling has been to maintain a precise control of coring depths, and to limit the influence of surface heave on drill bit motion. Operating in water depths between 1 and 6 km, the Ocean Drilling Program has relied on a drill string heave compensator to collect more than 200 km of cores, with maximum penetration of 2km. To evaluate the efficiency of the heave compensation, a device was developed to measure downhole acceleration from the top of the core barrel. This probe records three-axis acceleration and pressure at up to 100 samples per second. The first deployments of this instrument on ODP Legs 185 and 191 show that the heave compensator limits the bit motion to about 10% of the surface heave. This device could prove most useful to monitor heave compensation on shallow water drilling platforms where heave is a primary concern. The high-resolution downhole acceleration data can also be used to determine some of the mechanical properties of the formation. When deployed on piston cores, a maximum vertical acceleration of up to 3G is recorded as the coring shoe penetrates the formation. This maximum value is characteristic of the sediment strength and its degree of consolidation and can be used to identify formations that are typically difficult to recover, such as hard layers or hydrate-bearing sediments. With rotary coring, downhole acceleration signals decrease in magnitude and frequency content with the increasing hardness of the formation. High amplitude is observed in uncompacted sediments and low amplitudes in low-porosity oceanic basalt. Comparison between acceleration records and geophysical logs show that this relationship can be observed at a dm-scale within an individual core. Easy to deploy and adding almost no time to coring operations, the downhole accelerometer tool offers a way to characterize formations continuously while coring, which is particularly useful in the event of poor core recovery.

  8. Biocompatibility evaluation of magnetosomes formed by Acidithiobacillus ferrooxidans

    Energy Technology Data Exchange (ETDEWEB)

    Yan Lei [Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (China); College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319 (China); Yue Xiaoxuan [Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (China); Zhang Shuang [College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319 (China); Chen Peng [Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (China); GIBT, Gansu Institute of Business and Technology, Yannan Road 18, Lanzhou, 730010 (China); Xu Zhiliang; Li Yang [Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (China); Li Hongyu, E-mail: hekouyanlei@gmail.com [Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou, 730000 (China)

    2012-10-01

    Magnetite nanocrystal has been extensively used in biomedical field. Currently, an interesting alternative to synthetic magnetic Fe{sub 3}O{sub 4} nanoparticles, called magnetosome, has been found in magnetotactic bacteria. It has been reported that Acidithiobacillus ferrooxidans (At. ferrooxidans) has a potential to synthesize magnetosome. In this study, transmission electron microscope (TEM) was used to analyze the magnetite particles in At. ferrooxidans BY-3. The magnetosomes formed by this bacterium were isolated by a method combining ultracentrifugation and magnetic separation. Crystalline phase and surface functional group of the magnetosomes were investigated by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), respectively. Biocompatibility of the magnetosomes was systematically evaluated at various concentrations (0.5, 1.0, 2.0 and 4.0 mg/ml). MTT test, hemolysis assay and Micronucleus Test were carried out to evaluate in vitro cytotoxicity, blood toxicity and genotoxicity of magnetosomes, respectively. Under these conditions, magnetosomes showed no cytotoxic, genotoxic and hemolytic effects up to 4.0 mg/ml indicating good biocompatibility of these biological nanoparticles. These revealed that the magnetosomes might have a potential for biotechnological and biomedical applications in the future. - Highlights: Black-Right-Pointing-Pointer The production of magnetosomes from At. ferrooxidans has been easily available. Black-Right-Pointing-Pointer Several techniques are used to characterize properties of the magnetosomes. Black-Right-Pointing-Pointer The magnetosomes have no cytotoxicity, no hemolysis activity and no genotoxicity.

  9. Designing usable web forms- Empirical evaluation of web form improvement guidelines

    DEFF Research Database (Denmark)

    Seckler, Mirjam; Heinz, Silvia; Bargas-Avila, Javier A.

    2014-01-01

    This study reports a controlled eye tracking experiment (N = 65) that shows the combined effectiveness of 20 guidelines to improve interactive online forms when applied to forms found on real company websites. Results indicate that improved web forms lead to faster completion times, fewer form su...... submission trials, and fewer eye movements. Data from subjective questionnaires and interviews further show increased user satisfaction. Overall, our findings highlight the importance for web designers to improve their web forms using UX guidelines.......This study reports a controlled eye tracking experiment (N = 65) that shows the combined effectiveness of 20 guidelines to improve interactive online forms when applied to forms found on real company websites. Results indicate that improved web forms lead to faster completion times, fewer form...

  10. The research of the evaluation system towards a core enterprise's network capability in the industrial technology alliance

    Science.gov (United States)

    Yan, Guangshi; Tian, Xuelian; Shen, Xue; You, Yue

    2017-05-01

    The social network theory is introduced for the industrial technology alliance based on the actual needs of the development of the industrial technology alliance. Through discussing the influence of the core enterprise network capacity on alliance performance, this article establishes evaluation system and index model of core enterprise network ability. We also evaluate and analyze the network capacity of core enterprise by fuzzy comprehensive evaluation method. So, the evaluation method is very important and full of practical value with a new research vision.

  11. Evaluating core technology capacity based on an improved catastrophe progression method: the case of automotive industry

    Science.gov (United States)

    Zhao, Shijia; Liu, Zongwei; Wang, Yue; Zhao, Fuquan

    2017-01-01

    Subjectivity usually causes large fluctuations in evaluation results. Many scholars attempt to establish new mathematical methods to make evaluation results consistent with actual objective situations. An improved catastrophe progression method (ICPM) is constructed to overcome the defects of the original method. The improved method combines the merits of the principal component analysis' information coherence and the catastrophe progression method's none index weight and has the advantage of highly objective comprehensive evaluation. Through the systematic analysis of the influencing factors of the automotive industry's core technology capacity, the comprehensive evaluation model is established according to the different roles that different indices play in evaluating the overall goal with a hierarchical structure. Moreover, ICPM is developed for evaluating the automotive industry's core technology capacity for the typical seven countries in the world, which demonstrates the effectiveness of the method.

  12. Preliminary evaluation of alternative forms for immobilization of Savannah River Plant high-level waste. [Eleven alternative solid forms

    Energy Technology Data Exchange (ETDEWEB)

    Stone, J.A.; Goforth, S.T. Jr.; Smith, P.K.

    1979-12-01

    An evaluation of available information on eleven alternative solid forms for immobilization of SRP high-level waste has been completed. Based on the assessment of both product and process characteristics, four forms were selected for more detailed evaluation: (1) borosilicate glass made in the reference process, (2) a high-silica glass made from a porous glass matrix, (3) crystalline ceramics such as supercalcine or SYNROC, and (4) ceramics coated with an impervious barrier. The assessment includes a discussion of product and process characteristics for each of the eleven forms, a cross comparison of these characteristics for the forms, and the bases for selecting the most promising forms for further study.

  13. Toward a Comprehensive Framework for Evaluating the Core Integration Features of Enterprise Integration Middleware Technologies

    Directory of Open Access Journals (Sweden)

    Hossein Moradi

    2013-01-01

    Full Text Available To achieve greater automation of their business processes, organizations face the challenge of integrating disparate systems. In attempting to overcome this problem, organizations are turning to different kinds of enterprise integration. Implementing enterprise integration is a complex task involving both technological and business challenges and requires appropriate middleware technologies. Different enterprise integration solutions provide various functions and features which lead to the complexity of their evaluation process. To overcome this complexity, appropriate tools for evaluating the core integration features of enterprise integration solutions is required. This paper proposes a new comprehensive framework for evaluating the core integration features of both intra-enterprise and inter-enterprise Integration's enabling technologies, which simplify the process of evaluating the requirements met by enterprise integration middleware technologies.The proposed framework for evaluating the core integration features of enterprise integration middleware technologies was enhanced using the structural and conceptual aspects of previous frameworks. It offers a new schema for which various enterprise integration middleware technologies are categorized in different classifications and are evaluated based on their supporting level for the core integration features' criteria. These criteria include the functional and supporting features. The proposed framework, which is a revised version of our previous framework in this area, has developed the scope, structure and content of the mentioned framework.

  14. A CS J=5-->4 Mapping Survey Toward High-Mass Star-forming Cores Associated with Water Masers

    Science.gov (United States)

    Shirley, Yancy L.; Evans, Neal J., II; Young, Kaisa E.; Knez, Claudia; Jaffe, Daniel T.

    2003-12-01

    We have mapped 63 regions forming high-mass stars in CS J=5-->4 using the CSO. The CS peak position was observed in C34S J=5-->4 toward 57 cores and in 13CS J=5-->4 toward the nine brightest cores. The sample is a subset of a sample originally selected toward water masers; the selection on maser sources should favor sources in an early stage of evolution. The cores are located in the first and second Galactic quadrants with an average distance of 5.3+/-3.7 kpc and were well detected with a median peak signal-to-noise ratio in the integrated intensity of 40. The integrated intensity of CS J=5-->4 correlates very well with the dust continuum emission at 350 μm. For 57 sufficiently isolated cores, a well-defined angular size (FWHM) was determined. The core radius (RCS), aspect ratio [(a/b)obs], virial mass (Mvir), surface density (Σ), and the luminosity in the CS J=5-->4 line (L(CS54)) are calculated. The distributions of size, virial mass, surface density, and luminosity are all peaked with a few cores skewed toward much larger values than the mean. The median values, μ1/2, are as follows: μ1/2 (RCS)=0.32 pc, μ1/2 ((a/b)obs)=1.20, μ1/2 (Mvir)=920 Msolar, μ1/2 (Σ)=0.60 g cm-2, μ1/2 (L(CS54))=1.9×10-2 Lsolar, and μ1/2 (Lbol/Mvir)=165 (L/M)solar. We find a weak correlation between C34S line width and size, consistent with Δv~R0.3. The line widths are much higher than would be predicted by the usual relations between line width and size determined from regions of lower mass. These regions are very turbulent. The derived virial mass agrees within a factor of 2-3 with mass estimates from dust emission at 350 μm after corrections for the density structure are accounted for. The resulting cumulative mass spectrum of cores above 1000 Msolar can be approximated by a power law with a slope of about -0.9, steeper than that of clouds measured with tracers of lower density gas and close to that for the total masses of stars in OB associations. The median turbulent

  15. Organic Chemistry of Low-Mass Star-Forming Cores. I. 7 mm Spectroscopy of Chamaeleon MMSl

    Science.gov (United States)

    Cordiner, Martn A.; Charnley, Steven B.; Wirtstroem, Eva S.; Smith, Robert G.

    2012-01-01

    Observations are presented of emission lines from organic molecules at frequencies 32-50 GHz in the vicinity of Chamaeleon MMS1. This chemically rich dense cloud core harbors an extremely young, very low luminosity protostellar object and is a candidate first hydrostatic core. Column densities are derived and emission maps are presented for species including polyynes, cyanopolyynes, sulphuretted carbon chains, and methanol. The polyyne emission peak lies about 5000 AU from the protostar, whereas methanol peaks about 15,000 AU away. Averaged over the telescope beam, the molecular hydrogen number density is calculated to be 10(exp 6) / cubic cm and the gas kinetic temperature is in the range 5-7 K. The abundances of long carbon chains are very large and are indicative of a nonequilibrium carbon chemistry; C6H and HC7N column densities are 5.9(sup +2.9) (sub -1.3) x 10(exp 11) /cubic cm and 3.3 (sup +8.0)(sub -1.5) x 10(exp 12)/sq cm, respectively, which are similar to the values found in the most carbon-chain-rich protostars and prestellar cores known, and are unusually large for star-forming gas. Column density upper limits were obtained for the carbon chain anions C4H(-) and C6H(-), with anion-to-neutral ratios [C4H(-)]/[C4H] < 0.02% and [C6H(-l)]/[C6H] < 10%, consistent with previous observations in interstellar clouds and low-mass protostars. Deuterated HC,3 and c-C3H2 were detected. The [DC3N]/[HC,N] ratio of approximately 4% is consistent with the value typically found in cold interstellar gas.

  16. Organic Chemistry of Low-Mass Star-Forming Cores. I. 7 mm Spectroscopy of Chamaeleon MMSl

    Science.gov (United States)

    Cordiner, Martn A.; Charnley, Steven B.; Wirtstroem, Eva S.; Smith, Robert G.

    2012-01-01

    Observations are presented of emission lines from organic molecules at frequencies 32-50 GHz in the vicinity of Chamaeleon MMS1. This chemically rich dense cloud core harbors an extremely young, very low luminosity protostellar object and is a candidate first hydrostatic core. Column densities are derived and emission maps are presented for species including polyynes, cyanopolyynes, sulphuretted carbon chains, and methanol. The polyyne emission peak lies about 5000 AU from the protostar, whereas methanol peaks about 15,000 AU away. Averaged over the telescope beam, the molecular hydrogen number density is calculated to be 10(exp 6) / cubic cm and the gas kinetic temperature is in the range 5-7 K. The abundances of long carbon chains are very large and are indicative of a nonequilibrium carbon chemistry; C6H and HC7N column densities are 5.9(sup +2.9) (sub -1.3) x 10(exp 11) /cubic cm and 3.3 (sup +8.0)(sub -1.5) x 10(exp 12)/sq cm, respectively, which are similar to the values found in the most carbon-chain-rich protostars and prestellar cores known, and are unusually large for star-forming gas. Column density upper limits were obtained for the carbon chain anions C4H(-) and C6H(-), with anion-to-neutral ratios [C4H(-)]/[C4H] < 0.02% and [C6H(-l)]/[C6H] < 10%, consistent with previous observations in interstellar clouds and low-mass protostars. Deuterated HC,3 and c-C3H2 were detected. The [DC3N]/[HC,N] ratio of approximately 4% is consistent with the value typically found in cold interstellar gas.

  17. Organic Chemistry of Low-Mass Star-Forming Cores. I. 7 mm Spectroscopy of Chamaeleon MMSl

    Science.gov (United States)

    Cordiner, Martn A.; Charnley, Steven B.; Wirtstroem, Eva S.; Smith, Robert G.

    2012-01-01

    Observations are presented of emission lines from organic molecules at frequencies 32-50 GHz in the vicinity of Chamaeleon MMS1. This chemically rich dense cloud core harbors an extremely young, very low luminosity protostellar object and is a candidate first hydrostatic core. Column densities are derived and emission maps are presented for species including polyynes, cyanopolyynes, sulphuretted carbon chains, and methanol. The polyyne emission peak lies about 5000 AU from the protostar, whereas methanol peaks about 15,000 AU away. Averaged over the telescope beam, the molecular hydrogen number density is calculated to be 10(exp 6) / cubic cm and the gas kinetic temperature is in the range 5-7 K. The abundances of long carbon chains are very large and are indicative of a nonequilibrium carbon chemistry; C6H and HC7N column densities are 5.9(sup +2.9) (sub -1.3) x 10(exp 11) /cubic cm and 3.3 (sup +8.0)(sub -1.5) x 10(exp 12)/sq cm, respectively, which are similar to the values found in the most carbon-chain-rich protostars and prestellar cores known, and are unusually large for star-forming gas. Column density upper limits were obtained for the carbon chain anions C4H(-) and C6H(-), with anion-to-neutral ratios [C4H(-)]/[C4H] mass protostars. Deuterated HC,3 and c-C3H2 were detected. The [DC3N]/[HC,N] ratio of approximately 4% is consistent with the value typically found in cold interstellar gas.

  18. Supported Ag-TiO{sub 2} core-shell nanofibres formed at low temperature by plasma deposition

    Energy Technology Data Exchange (ETDEWEB)

    Borras, Ana; Barranco, Angel; Yubero, Francisco; Gonzalez-Elipe, Agustin R [Instituto de Ciencia de Materiales de Sevilla (CSIC-Univ. Sevilla), Avenida Americo Vespucio s/n, 41092 Sevilla (Spain)

    2006-07-28

    Ag-TiO{sub 2} nanofibres (about three {mu}m long and 30-150 nm thick) formed by a single-crystalline silver wire (20-30 nm thick) and an external layer of amorphous TiO{sub 2} of variable thickness are prepared at 403 K by oxygen plasma activation of a silver substrate followed by plasma deposition of TiO{sub 2}. Thicker fibres of anatase crystallites surrounding the silver wire were prepared when plasma deposition was carried out at 523 K. The fibres have been analysed by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and x-ray photoemission spectroscopy (XPS). The plasmon losses of the silver core wire have been characterized by electron energy loss spectroscopy in the TEM microscope. Based on the experimental evidence, a new volcano-type mechanism of formation of these core-shell fibres is proposed, whereby the effect of the plasma and the high mobility of the silver would be key factors determining their morphology and dimensions.

  19. Energetic activity in a star-forming molecular cloud core - A disk constrained bipolar outflow in NGC 2071

    Science.gov (United States)

    Bally, J.

    1982-10-01

    The discovery of an extended, high-velocity molecular outflow associated with the IR sources in NGC 2071 is reported. High-velocity CO emission from this star-forming molecular cloud core can be traced over a region 4 arcmin in diameter and detected over a velocity range of 70 km/sec. The flow is bipolar; the blueshifted CO emission is displaced to the northeast, while the redshifted emission is displaced to the southwest. Observations in the 98 GHz transition of CS reveal a ridge of dense gas oriented orthogonal to the high-velocity flow axis. A systematic velocity gradient seen in the CS line core suggests that the ridge is a dense, rotating disk centered on the IR source. The disk may be responsible for collimating a spherically symmetric wind originating near the IR source into the bipolar flow observed in the high-velocity CO line wings. The high-velocity CO line wings are modeled as beam diluted emission from clumps or filaments with C-12O optical depths close to unity and a small filling factor. The clumps may be either objects ejected from the vicinity of the central infrared source or shocked gas at the front where a higher velocity but invisible flow encounters ambient cloud material.

  20. Magnetic Fields in Star-Forming Molecular Clouds III. Submillimeter Polarimetry of Intermediate Mass Cores and Filaments in Orion B

    CERN Document Server

    Matthews, B C; Moriarty-Schieven, G H

    2002-01-01

    Using the imaging polarimeter for the Submillimeter Common User Bolometric Array at the James Clerk Maxwell Telescope, we have detected polarized thermal emission at 850 micron from dust toward three star-forming core systems in the Orion B molecular cloud: NGC 2071, NGC 2024 and LBS 23N (HH 24). The polarization patterns are not indicative of those expected for magnetic fields dominated by a single field direction, and all exhibit diminished polarization percentages toward the highest intensity peaks. NGC 2024 has the most organized polarization pattern which is centered consistently along the length of a chain of 7 far-infrared sources. We have modeled NGC 2024 using a helical field geometry threading a curved filament and also as a magnetic field swept up by the ionization front of the expanding HII region. In the latter case, the field is bent by the dense ridge, which accounts for both the polarization pattern and existing measurements of the line-of-sight field strength toward the northern cores FIR 1 t...

  1. Evaluation on Core Competitiveness of Wholesale Market of Agricultural Products Based on CWAA Operator

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    According to relevant data,we select five indices,namely management ability,organization and management capability,enterprise culture,development ability and technical equipment ability,to establish the index system of core competitiveness of wholesale market of agricultural products.Based on combination weight arithmetic average(CWAA) operator,we advance an evaluation model of core competitiveness of wholesale market of agricultural products which involves participation of many people.By inviting five exerts,we conduct evaluation in terms of management ability of wholesale market of agricultural products,organization and management capability of leadership,enterprise culture of wholesale market of agricultural products,future development ability of wholesale market of agricultural products,and exiting technical equipment ability of wholesale market of agricultural products.We adopt hundred-mark system to grade and evaluate core competitiveness of wholesale market of agricultural products.The results show that the experts’ evaluation score of core competitiveness of wholesale market of agricultural products is high.The evaluation result is reasonable and authentic and this model is feasible.

  2. Evaluation of neutronic characteristic of irradiation field in MEU6-core. Comparison of neutron flux and neutron spectrum in MEU6-core and Mixed-core

    Energy Technology Data Exchange (ETDEWEB)

    Nagao, Yoshiharu; Komukai, Bunsaku; Tabata, Toshio; Takeda, Takashi; Fujiki, Kazuo [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    1999-08-01

    In JMTR (Japan Materials Testing Reactor, 50 MW), the core configuration has been changed from previously employed Mixed-core (25 LEUs(low enrichment uranium (19.8%) fuel elements) and 2 MEUs (medium enrichment uranium (45%) fuel elements)) to MEU6-core (21 LEUs and 6 MEUs), since 125th operating cycle (started in Nov. 17, 1998). In order to investigate the effect of core configuration change on the irradiation tests, neutron flux distribution and neutron spectrum of irradiation field in MEU6-core were calculated by diffusion code CITATION and Monte Carlo code MCNP. As the result, it was confirmed that irradiation field in the MEU6-core has the neutronic characteristics almost equivalent to the irradiation field in the Mixed-core. (author)

  3. Testing of a measurement model for baccalaureate nursing students' self-evaluation of core competencies.

    Science.gov (United States)

    Hsu, Li-Ling; Hsieh, Suh-Ing

    2009-11-01

    Testing of a measurement model for baccalaureate nursing students' self-evaluation of core competencies. This paper is a report of a study to test the psychometric properties of the Self-Evaluated Core Competencies Scale for baccalaureate nursing students. Baccalaureate nursing students receive basic nursing education and continue to build competency in practice settings after graduation. Nursing students today face great challenges. Society demands analytic, critical, reflective and transformative attitudes from graduates. It also demands that institutions of higher education take the responsibility to encourage students, through academic work, to acquire knowledge and skills that meet the needs of the modern workplace, which favours highly skilled and qualified workers. A survey of 802 senior nursing students in their last semester at college or university was conducted in Taiwan in 2007 using the Self-Evaluated Core Competencies Scale. Half of the participants were randomly assigned either to principal components analysis with varimax rotation or confirmatory factor analysis. Principal components analysis revealed two components of core competencies that were named as humanity/responsibility and cognitive/performance. The initial model of confirmatory factor analysis was then converged to an acceptable solution but did not show a good fit; however, the final model of confirmatory factor analysis was converged to an acceptable solution with acceptable fit. The final model has two components, namely humanity/responsibility and cognitive/performance. Both components have four indicators. In addition, six indicators have their correlated measurement errors. Self-Evaluated Core Competencies Scale could be used to assess the core competencies of undergraduate nursing students. In addition, it should be used as a teaching guide to increase students' competencies to ensure quality patient care in hospitals.

  4. Comparative evaluation of adverse drug reaction reporting forms for introduction of a spontaneous generic ADR form

    Directory of Open Access Journals (Sweden)

    Anshi Singh

    2012-01-01

    Full Text Available Despite comprehensive and stringent phases of clinical trials and surveillance efforts, unexpected and serious adverse drug reactions (ADRs repeatedly occur after the drug is marketed. ADR reporting is an important aspect of an efficient and effective pharmacovigilance program. Although Medwatch, Yellow Card, CDSCO form, etc. are the protocol forms of ADR collection and reports, a number of countries design and use their respective ADR forms. This review compares similarities and dissimilarities of 13 ADR forms of countries representing their geographical location. This study extracted 73 data elements mentioned in 13 different ADR forms. Only 13 elements were common. An ADR form of Malaysia and Canada covers the highest number of data 43, while Brazil falls to the opposite end with a number of 17 data elements in lieu with the Generic ADR Form. The result of this review highlights 58 data elements of the proposed generic ADR form which ensures that requisite reporting information essential for correct causality assessment of ADRs are included. The proposed "Generic ADR form" could be adopted worldwide mandatorily for reporting any/all ADRs associated with marketed drugs.

  5. Core Self-Evaluations as Causes of Satisfaction: The Mediating Role of Seeking Task Complexity

    Science.gov (United States)

    Srivastava, Abhishek; Locke, Edwin A.; Judge, Timothy A.; Adams, John W.

    2010-01-01

    This study examined the mediating role of task complexity in the relationship between core self-evaluations (CSE) and satisfaction. In Study 1, eighty three undergraduate business students worked on a strategic decision-making simulation. The simulated environment enabled us to verify the temporal sequence of variables, use an objective measure of…

  6. Core Self-Evaluations as Causes of Satisfaction: The Mediating Role of Seeking Task Complexity

    Science.gov (United States)

    Srivastava, Abhishek; Locke, Edwin A.; Judge, Timothy A.; Adams, John W.

    2010-01-01

    This study examined the mediating role of task complexity in the relationship between core self-evaluations (CSE) and satisfaction. In Study 1, eighty three undergraduate business students worked on a strategic decision-making simulation. The simulated environment enabled us to verify the temporal sequence of variables, use an objective measure of…

  7. Evaluation of apple fruit aroma character from Geneva Malus core collection

    Science.gov (United States)

    Mature apple fruit from 184 lines (41 species) from the Malus core and Kazakhstan collections of the germplasm repository at the New York Agricultural Experiment Station in Geneva, NY were evaluated. Volatile compounds, taste, weight, internal ethylene concentration, starch index, firmness, and Brix...

  8. How can core self-evaluations influence job burnout? The key roles of organizational commitment and job satisfaction.

    Science.gov (United States)

    Peng, Jiaxi; Li, Dongdong; Zhang, Zhenjiang; Tian, Yu; Miao, Danmin; Xiao, Wei; Zhang, Jiaxi

    2016-01-01

    This study aimed to explore how core self-evaluations influenced job burnout and mainly focused on the confirmation of the mediator roles of organizational commitment and job satisfaction. A total of 583 female nurses accomplished the Core Self-Evaluation Scale, Organizational Commitment Scale, Minnesota Satisfaction Questionnaire, and Maslach Burnout Inventory-General Survey. The results revealed that core self-evaluations, organizational commitment, job satisfaction, and job burnout were significantly correlated with each other. Structural equation modeling indicated that core self-evaluations can significantly influence job burnout and are completely mediated by organizational commitment and job satisfaction.

  9. Design and pilot evaluation of the RAH-66 Comanche Core AFCS

    Science.gov (United States)

    Fogler, Donald L., Jr.; Keller, James F.

    1993-01-01

    This paper addresses the design and pilot evaluation of the Core Automatic Flight Control System (AFCS) for the Reconnaissance/Attack Helicopter (RAH-66) Comanche. During the period from November 1991 through February 1992, the RAH-66 Comanche control laws were evaluated through a structured pilot acceptance test using a motion base simulator. Design requirements, descriptions of the control law design, and handling qualities data collected from ADS-33 maneuvers are presented.

  10. Impact of the Cooling Equipment on the Key Design Parameters of a Core-Form Power Transformer

    Science.gov (United States)

    Orosz, Tamás; Tamus, Zoltán Ádám

    2016-12-01

    The first step in the transformer design process is to find the active part's key design parameters. This is a non-linear mathematical optimisation task, which becomes more complex if the economic conditions are considered by the capitalisation of the losses. Geometric programming combined with the method of branch and bound can be an effective and accurate tool for this task even in the case of core-form power transformers, when formulating the short-circuit impedance in the required form is problematic. Most of the preliminary design methods consider only the active part of the transformer and the capitalised costs in order to determine the optimal key design parameters. In this paper, an extension of this meta-heuristic transformer optimisation model, which takes the cost of the insulating oil and the cooling equipment into consideration, is presented. Moreover, the impact of the new variables on the optimal key design parameters of a transformer design is examined and compared with the previous algorithm in two different economic scenarios. Significant difference can be found between the optimal set of key-design parameters if these new factors are considered.

  11. Performance evaluation of the Hermite scheme on many-core accelerators

    Science.gov (United States)

    Nakasato, Naohito

    2016-02-01

    We are developing a software library to calculate gravitational interaction for the Hermite scheme on parallel computing systems supported by OpenCL API. Our library is partly compatible with a standard GRAPE-6A interface and is easily usable in existing N-body codes. Since our library is based on OpenCL standard API, our library is working on many parallel computing systems such as a multi-core CPU, a GPU, and a many-core architecture. We report the performance evaluation of our library on computing platforms from various vendors.

  12. Student Personality Differences Are Related to Their Responses on Instructor Evaluation Forms

    Science.gov (United States)

    McCann, Stewart; Gardner, Christopher

    2014-01-01

    The relation of student personality to student evaluations of teaching (SETs) was determined in a sample of 144 undergraduates. Student Big Five personality variables and core self-evaluation (CSE) were assessed. Students rated their most preferred instructor (MPI) and least preferred instructor (LPI) on 11 common evaluation items. Pearson and…

  13. ORGANIC CHEMISTRY OF LOW-MASS STAR-FORMING CORES. I. 7 mm SPECTROSCOPY OF CHAMAELEON MMS1

    Energy Technology Data Exchange (ETDEWEB)

    Cordiner, Martin A.; Charnley, Steven B.; Wirstroem, Eva S. [Astrochemistry Laboratory and Goddard Center for Astrobiology, NASA Goddard Space Flight Center, Greenbelt, MD 20770 (United States); Smith, Robert G., E-mail: martin.cordiner@nasa.gov [School of Physical, Environmental, and Mathematical Sciences, University of New South Wales, Australian Defence Force Academy, Canberra, ACT 2600 (Australia)

    2012-01-10

    Observations are presented of emission lines from organic molecules at frequencies 32-50 GHz in the vicinity of Chamaeleon MMS1. This chemically rich dense cloud core harbors an extremely young, very low luminosity protostellar object and is a candidate first hydrostatic core. Column densities are derived and emission maps are presented for species including polyynes, cyanopolyynes, sulphuretted carbon chains, and methanol. The polyyne emission peak lies about 5000 AU from the protostar, whereas methanol peaks about 15,000 AU away. Averaged over the telescope beam, the molecular hydrogen number density is calculated to be 10{sup 6} cm{sup -3} and the gas kinetic temperature is in the range 5-7 K. The abundances of long carbon chains are very large and are indicative of a non-equilibrium carbon chemistry; C{sub 6}H and HC{sub 7}N column densities are 5.9{sup +2.9}{sub -1.3} Multiplication-Sign 10{sup 11} cm{sup -2} and 3.3{sup +8.0}{sub -1.5} Multiplication-Sign 10{sup 12} cm{sup -2}, respectively, which are similar to the values found in the most carbon-chain-rich protostars and prestellar cores known, and are unusually large for star-forming gas. Column density upper limits were obtained for the carbon-chain anions C{sub 4}H{sup -} and C{sub 6}H{sup -}, with anion-to-neutral ratios [C{sub 4}H{sup -}]/[C{sub 4}H] < 0.02% and [C{sub 6}H{sup -}]/[C{sub 6}H] < 10%, consistent with previous observations in interstellar clouds and low-mass protostars. Deuterated HC{sub 3}N and c-C{sub 3}H{sub 2} were detected. The [DC{sub 3}N]/[HC{sub 3}N] ratio of approximately 4% is consistent with the value typically found in cold interstellar gas.

  14. Short-Form Philadelphia Naming Test: Rationale and Empirical Evaluation

    Science.gov (United States)

    Walker, Grant M.; Schwartz, Myrna F.

    2012-01-01

    Purpose: To create two matched short forms of the Philadelphia Naming Test (PNT; Roach, Schwartz, Martin, Grewal, & Brecher, 1996) that yield similar results to the PNT for measuring anomia. Method: In Study 1, archived naming data from 94 individuals with aphasia were used to identify which PNT items should be included in the short forms. The 2…

  15. Cross-platform digital assessment forms for evaluating surgical skills

    DEFF Research Database (Denmark)

    Andersen, Steven Arild Wuyts

    2015-01-01

    containing the digital assessment forms, because this software has cross-platform functionality on both desktop computers and handheld devices. The database is hosted online, and the rating forms can therefore also be accessed through most modern web browsers. Cross-platform digital assessment forms were...... developed for the rating of surgical skills. The database platform used in this study was reasonably priced, intuitive for the user, and flexible. The forms have been provided online as free downloads that may serve as the basis for further development or as inspiration for future efforts. In conclusion...... assessment situations. In this paper, we report on the development of cross-platform digital assessment forms for use with multiple raters in order to facilitate the automatic processing of surgical skills assessments that include structured ratings. The FileMaker 13 platform was used to create a database...

  16. Evaluation of The Value of Core Needle Biopsy in The Diagnosis of a Breast Mass

    Directory of Open Access Journals (Sweden)

    Asieh Sadat Fattahi

    2016-06-01

    Full Text Available Background: Core needle biopsy (CNB with histological findings is regarded as one of the most important diagnostic measures that make preoperative assessment and planning for appropriate treatment possible. The aim of this study was to determine the sensitivity and specificity of core biopsy results in our patients with benign and malignant breast lumps, especially for borderline breast lesions, by using a classification method.Methods: In this study, 116 patients who were referred to the Surgery Clinic of Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran with breast lump and underwent diagnostic procedures such as mammography and ultrasound were selected. Core needle biopsy (Tru-cut #14 or 16 was performed. After that, excisional biopsy was done. The benign, malignant and unspecified samples obtained by core needle biopsy were evaluated with the samples of the surgical and pathological findings. Then, false positive, false negative, sensitivity, specificity, and diagnostic accuracy of the core needle biopsy method were calculated. Also, the National Health Service Breast Screening Program (NHSBSP classification was employed.Results: The mean age of the participants in this study was 39±13.13 years and the mean tumor size was 2.7 cm. An average of 3.35 biopsies was taken from all patients. Most of the pathology samples taken from CNB and excisional biopsy were compatible with invasive ductal carcinoma. Of the B type classifications, B5 was the most frequent in both methods. Borderline lesions B3 and B4 had a change in their category after surgery. About 2.5% of the samples in core biopsy were inadequate. Skin bruising was the most common core biopsy complication reported. While, the most common complication of excisional biopsy was hematoma. Accuracy, sensitivity, specificity, positive and negative predictive values of the core needle biopsy procedure compared with excisional biopsy was 95.5%, 92.6%, 100%, 100%, and 91

  17. Evaluation of the Shielding Characteristics Test around the Reactor Core in the Prototype Fbr Monju

    Science.gov (United States)

    Usami, Shin; Suzuoki, Zenro; Deshimaru, Takehide; Nakashima, Fumiaki; Hikichi, Takuo

    2003-06-01

    In Monju, shielding measurements were made around the reactor core as a part of the system start-up tests in order to evaluate the design margins of the shielding performance, to demonstrate the validity of the shielding analysis method, and to acquire basic data for use in future FBR design. The measured reaction rates have been obtained radially from the core to the in-vessel storage rack and axially to the reactor vessel upper plenum. The measured values (E) were compared with the calculated values (C) obtained with the FBR shielding analysis system on the basis of the nuclear data library JENDL-3.2. Based upon these results, the design margins around the reactor core have been examined.

  18. Reaction rate distribution measurement and the core performance evaluation in the prototype FBR Monju

    Energy Technology Data Exchange (ETDEWEB)

    Usami, S.; Suzuoki, Z.; Deshimaru, T. [Monju Construction Office, Japan Nuclear Cycle Development Institute, Fukui-ken (Japan); Nakashima, F. [Tsuruga head Office, Japan Nuclear Cycle Development Institute, Fukui-ken (Japan)

    2001-07-01

    Monju is a prototype fast breeder reactor designed to have an output of 280 MW (714 MWt), fueled with mixed oxides of plutonium and uranium and cooled by liquid sodium. The principal data on plant design and performance are shown in Table 1. Monju attained initial criticality in April 1994 and the reactor physics tests were carried out from May through November 1994. The reaction rate distribution measurement by the foil activation method was one of these tests and was carried out in order to verify the core performance and to contribute to the development of the core design methods. On the basis of the reaction rate measurement data, the Monju initial core breeding ratio and the power distribution were evaluated. (author)

  19. Experimental Evaluation of Tuned Chamber Core Panels for Payload Fairing Noise Control

    Science.gov (United States)

    Schiller, Noah H.; Allen, Albert R.; Herlan, Jonathan W.; Rosenthal, Bruce N.

    2015-01-01

    Analytical models have been developed to predict the sound absorption and sound transmission loss of tuned chamber core panels. The panels are constructed of two facesheets sandwiching a corrugated core. When ports are introduced through one facesheet, the long chambers within the core can be used as an array of low-frequency acoustic resonators. To evaluate the accuracy of the analytical models, absorption and sound transmission loss tests were performed on flat panels. Measurements show that the acoustic resonators embedded in the panels improve both the absorption and transmission loss of the sandwich structure at frequencies near the natural frequency of the resonators. Analytical predictions for absorption closely match measured data. However, transmission loss predictions miss important features observed in the measurements. This suggests that higher-fidelity analytical or numerical models will be needed to supplement transmission loss predictions in the future.

  20. Evaluation of drug release from coated pellets based on isomalt, sugar, and microcrystalline cellulose inert cores.

    Science.gov (United States)

    Kállai, Nikolett; Luhn, Oliver; Dredán, Judit; Kovács, Kristóf; Lengyel, Miléna; Antal, István

    2010-03-01

    The objective of the present study was to investigate the effect of the pellet core materials isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustained-release pellets as well as to evaluate the influence of different ratios of polymethacrylate copolymers exhibiting different permeability characteristics on the drug release rate. For characterization of the drug release process of pellets, the effect of osmolality was studied using glucose as an osmotically active agent in the dissolution medium. The pellet cores were layered with diclofenac sodium as model drug and coated with different ratios of Eudragit RS30D and Eudragit RL30D (ERS and ERL; 0:1 and 0.5:0.5 and 1:0 ratio) in a fluid bed apparatus. Physical characteristics such as mechanical strength, shape, and size proved that the inert cores were adequate for further processing. The in vitro dissolution tests were performed using a USP Apparatus I (basket method). The results demonstrated that, besides the ratio of the coating polymers (ERS/ERL), the release mechanism was also influenced by the type of starter core used. Sugar- and isomalt-type pellet cores demonstrated similar drug release profiles.

  1. 78 FR 56908 - 30-Day Notice of Proposed Information Collection: Training Evaluation Form

    Science.gov (United States)

    2013-09-16

    ... URBAN DEVELOPMENT 30-Day Notice of Proposed Information Collection: Training Evaluation Form AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY: HUD has submitted the proposed... Information Collection Title of Information Collection: Training Evaluation Form. OMB Approval Number:...

  2. Evaluation of the FBR MONJU core breeding ratio and the power distribution from the reaction rate distribution measurement

    Energy Technology Data Exchange (ETDEWEB)

    Usami, Shin; Suzuki, Takayuki; Sasaki, Kenji; Deshimaru, Takehide [Power Reactor and Nuclear Fuel Development Corp., Tsuruga, Fukui (Japan). Monju Construction Office; Nakashima, Fumiaki

    1996-09-01

    In MONJU, reaction rate distribution measurements were made by foil activation methods from May through September 1994. On the basis of the reaction rate measurement data, the MONJU initial core breeding ratio and the power distribution, etc. were evaluated. As a result, the evaluated values and the calculated values showed good agreement, and we confirmed that the core performance of MONJU and the method of core calculations were satisfactory. (author)

  3. Development and experimental evaluation of a novel annuloplasty ring with a shape memory alloy core

    Science.gov (United States)

    Purser, Molly Ferris

    A novel annuloplasty ring with a shape memory alloy core has been developed to facilitate minimally invasive mitral valve repair. In its activated (austenitic) phase, this prototype ring provides comparable mechanical properties as commercial semi-rigid rings. In its pre-activated (martensitic) phase, this ring is flexible enough to be introduced through an 8 mm trocar and easily manipulated with robotic instruments within the confines of a left atrial model. The core is constructed of 0.508 mm diameter NiTi, which is maintained below its M s temperature (24°C) during deployment and suturing. After suturing, the stiffener is heated to its Af temperature (37°C, normal human body temperature) enabling the NiTi to retain its optimal geometry and stiffness characteristics indefinitely. The NiTi core is shape set in a furnace to the appropriate size and optimal geometry during fabrication. The ring is cooled in a saline bath prior to surgery, making it compliant and easy to manipulate. Evaluation of the ring included mechanical testing, robotic evaluation, static pressure testing, dynamic flow testing and fatigue testing. Experimental results suggest that the NiTi core ring could be a viable alternative to flexible bands in robot-assisted mitral valve repair.

  4. The Role of Personality Traits, Core Self-Evaluation, and Emotional Intelligence in Career Decision-Making Difficulties

    Science.gov (United States)

    Di Fabio, Annamaria; Palazzeschi, Letizia; Bar-On, Reuven

    2012-01-01

    This study examines the role of personality traits, core self-evaluation, and emotional intelligence (EI) in career decision-making difficulties. Italian university students (N = 232) responded to questions on the Big Five Questionnaire, Core Self-Evaluation Scale, Bar-On Emotional Quotient Inventory, and Career Decision-Making Difficulties…

  5. Core self-evaluation and burnout among Nurses: the mediating role of coping styles.

    Directory of Open Access Journals (Sweden)

    Xiaofei Li

    Full Text Available OBJECTIVES: This study aimed to determine the potential association between core self-evaluation and the burnout syndrome among Chinese nurses, and the mediating role of coping styles in this relationship. METHODS: A cross-sectional survey was conducted in Shenyang, China, from May to July, 2013. A questionnaire which consisted of the Maslach Burnout Inventory-General Survey (MBI-GS, the Core Self-Evaluation Scale (CSE, and the Simplified Coping Style Questionnaire (CSQ, was completed by a total of 1,559 nurses. Hierarchical linear regression analyses and the Sobel test were performed to determine the mediating role of coping styles on the relationship between CSE and burnout. RESULTS: Nurses who had higher self-evaluation characteristics, reported less emotional exhaustion and cynicism, and higher professional efficacy. Coping style had a partial mediating effect on the relationship between CSE and the burnout syndrome among nurses. CONCLUSIONS: Core self-evaluation had effects on burnout and coping style was a mediating factor in this relationship among Chinese nurses. Therefore, the improvement of coping strategies may be helpful in the prevention of burnout among nurses, thus enhancing professional performance.

  6. The reliability and validity of the American Board of Internal Medicine Monthly Evaluation Form.

    Science.gov (United States)

    Durning, Steven J; Cation, Lannie J; Jackson, Jeffrey L

    2003-11-01

    To report indicators of reliability and validity of the American Board of Internal Medicine Evaluation Form (ABIM-MEF) at one institution (Wright-Patterson Medical Center). Completed ABIM-MEFs from 1990-1999 were reviewed. Reliability measures included Cronbach alpha, interrater reliability, and rating consistency between different types of staff and rotations. Construct validity was investigated by tracking ABIM-MEF scores over time and with factor analysis. Predictive validity was assessed by correlating ABIM-MEF scores with the In-training Examination and ABIM Certifying Examination results The 71 residents averaged 12 ABIM-MEFs per year. The forms had a Cronbach alpha of 0.96 and high interrater reliability (intraclass correlation coefficients > 0.80). Ratings did not differ by type of attending or rotation, except that noninternists rated residents lower on procedural skills. ABIM-MEF questions about judgment, knowledge, and clinical skills showed significant improvement from month to month during each academic year as well as year to year. In contrast, questions on professional attitudes, humanism, and procedural skills sections improved between postgraduate year 1 and postgraduate year 2 only. ABIM-MEF questions collapsed into two domains in factor analysis: judgment-knowledge-skills and attitude-humanism. ABIM-MEF questions from judgment and knowledge sections modestly predicted In-training Examination and ABIM Certifying Examination results. In contrast, professional attitude, humanism, and clinical as well as procedural skill questions had little discriminative ability. The ABIM-MEF appears to be reliable and valid. Further, factor analysis results support the ABIM's movement to simplify the monthly evaluation form to the new Accreditation Council for Graduate Medical Education core competencies.

  7. The inductive form of preaching (F.B. Craddock – an exploration and evaluation

    Directory of Open Access Journals (Sweden)

    C. J.H Venter

    2005-07-01

    Full Text Available Within the wider field of research in homiletics special emphasis has been placed on investigation dealing with hermeneutical homiletics. In Europe Dingemans initiated research focused on this specific field of homiletics in 1991. In South Africa the research and findings of Pieterse and Vos on hermeneutical homiletics are prominent at this stage. The emphasis in research on this aspect of homiletics has, however, in a sense been preceded by the work of Fred Craddock – work that has till date not been highlighted and evaluated sufficiently by South African theologians. Craddock’s work in this field may be regarded as transitional in nature. In Craddock’s approach the focus has shifted from research dealing mainly with the formal aspects of preaching to research bringing into perspective, among others, an inductive form of preaching. In applying the inductive form of preaching the function of the hearer as interpreter is utilised. The power and generative use of language in a sermon is also brought to the fore in this form of preaching. Craddock has indeed brought to light core elements in homiletical research – elements still serving as a stimulus for research on hermeneutical homiletics. Craddock’s approach to preaching – the inductive method – directs the attention to the structure of the sermon, as well as the “movements” and the development of the train of thought within the sermon as essential elements of inductive preaching. Furthermore, the aim of uniting the different elements of the sermon and the use of imaginative language in a sermon is also stressed by Craddock’s method. In conclusion this article attempts an evaluation of some of Craddock’s viewpoints on preaching.

  8. Structure of the protein core of translation initiation factor 2 in apo, GTP-bound and GDP-bound forms

    Energy Technology Data Exchange (ETDEWEB)

    Simonetti, Angelita [IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Centre National de la Recherche Scientifique (CNRS) UMR 7104/Institut National de la Santé de la Recherche Médicale - INSERM U964/Université de Strasbourg, 1 Rue Laurent Fries, 67404 Illkirch (France); Marzi, Stefano [Architecture et Réactivité de l’ARN, UPR 9002 CNRS, IBMC (Institute of Molecular and Cellular Biology), 15 Rue R. Descartes, 67084 Strasbourg, France, Université de Strasbourg, 67000 Strasbourg (France); Fabbretti, Attilio [University of Camerino, 62032 Camerino (Monaco) (Italy); Hazemann, Isabelle; Jenner, Lasse [IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Centre National de la Recherche Scientifique (CNRS) UMR 7104/Institut National de la Santé de la Recherche Médicale -INSERM U964/Université de Strasbourg, 1 Rue Laurent Fries, 67404 Illkirch (France); Urzhumtsev, Alexandre [IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Centre National de la Recherche Scientifique (CNRS) UMR 7104/Institut National de la Santé de la Recherche Médicale - INSERM U964/Université de Strasbourg, 1 Rue Laurent Fries, 67404 Illkirch (France); Université de Lorraine, 54506 Vandoeuvre-lès-Nancy (France); Gualerzi, Claudio O. [University of Camerino, 62032 Camerino (Monaco) (Italy); Klaholz, Bruno P., E-mail: klaholz@igbmc.fr [IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Centre National de la Recherche Scientifique (CNRS) UMR 7104/Institut National de la Santé de la Recherche Médicale - INSERM U964/Université de Strasbourg, 1 Rue Laurent Fries, 67404 Illkirch (France)

    2013-06-01

    The crystal structures of the eubacterial translation initiation factor 2 in apo form and with bound GDP and GTP reveal conformational changes upon nucleotide binding and hydrolysis, notably of the catalytically important histidine in the switch II region. Translation initiation factor 2 (IF2) is involved in the early steps of bacterial protein synthesis. It promotes the stabilization of the initiator tRNA on the 30S initiation complex (IC) and triggers GTP hydrolysis upon ribosomal subunit joining. While the structure of an archaeal homologue (a/eIF5B) is known, there are significant sequence and functional differences in eubacterial IF2, while the trimeric eukaryotic IF2 is completely unrelated. Here, the crystal structure of the apo IF2 protein core from Thermus thermophilus has been determined by MAD phasing and the structures of GTP and GDP complexes were also obtained. The IF2–GTP complex was trapped by soaking with GTP in the cryoprotectant. The structures revealed conformational changes of the protein upon nucleotide binding, in particular in the P-loop region, which extend to the functionally relevant switch II region. The latter carries a catalytically important and conserved histidine residue which is observed in different conformations in the GTP and GDP complexes. Overall, this work provides the first crystal structure of a eubacterial IF2 and suggests that activation of GTP hydrolysis may occur by a conformational repositioning of the histidine residue.

  9. TADPOL: A 1.3 mm SURVEY OF DUST POLARIZATION IN STAR-FORMING CORES AND REGIONS

    Energy Technology Data Exchange (ETDEWEB)

    Hull, Charles L. H.; Plambeck, Richard L.; Bower, Geoffrey C.; Heiles, Carl [Astronomy Department and Radio Astronomy Laboratory, University of California, Berkeley, CA 94720-3411 (United States); Kwon, Woojin [SRON Netherlands Institute for Space Research, Landleven 12, 9747 AD Groningen (Netherlands); Carpenter, John M.; Lamb, James W.; Pillai, Thushara [Department of Astronomy, California Institute of Technology, 1200 E. California Blvd., MC 249-17, Pasadena, CA 91125 (United States); Crutcher, Richard M.; Hakobian, Nicholas S.; Looney, Leslie W. [Department of Astronomy, University of Illinois at Urbana-Champaign, 1002 W Green Street, Urbana, IL 61801 (United States); Fiege, Jason D.; Franzmann, Erica [Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB, R3T 2N2 (Canada); Houde, Martin [Department of Physics and Astronomy, University of Western Ontario, London, ON, N6A 3K7 (Canada); Hughes, A. Meredith [Van Vleck Observatory, Astronomy Department, Wesleyan University, 96 Foss Hill Drive, Middletown, CT 06459 (United States); Marrone, Daniel P. [Steward Observatory, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Matthews, Brenda C. [Department of Physics and Astronomy, University of Victoria, 3800 Finnerty Rd., Victoria, BC, V8P 5C2 (Canada); Pound, Marc W. [Astronomy Department and Laboratory for Millimeter-wave Astronomy, University of Maryland, College Park, MD 20742 (United States); Rahman, Nurur [Physics Department, University of Johannesburg, C1-Lab 140, P.O. Box 524, Auckland Park 2006 (South Africa); Sandell, Göran, E-mail: chat@astro.berkeley.edu [SOFIA Science Center, Universities Space Research Association, NASA Ames Research Center, Moffett Field, CA 94035 (United States); and others

    2014-07-01

    We present λ 1.3 mm Combined Array for Research in Millimeter-wave Astronomy observations of dust polarization toward 30 star-forming cores and eight star-forming regions from the TADPOL survey. We show maps of all sources, and compare the ∼2.''5 resolution TADPOL maps with ∼20'' resolution polarization maps from single-dish submillimeter telescopes. Here we do not attempt to interpret the detailed B-field morphology of each object. Rather, we use average B-field orientations to derive conclusions in a statistical sense from the ensemble of sources, bearing in mind that these average orientations can be quite uncertain. We discuss three main findings. (1) A subset of the sources have consistent magnetic field (B-field) orientations between large (∼20'') and small (∼2.''5) scales. Those same sources also tend to have higher fractional polarizations than the sources with inconsistent large-to-small-scale fields. We interpret this to mean that in at least some cases B-fields play a role in regulating the infall of material all the way down to the ∼1000 AU scales of protostellar envelopes. (2) Outflows appear to be randomly aligned with B-fields; although, in sources with low polarization fractions there is a hint that outflows are preferentially perpendicular to small-scale B-fields, which suggests that in these sources the fields have been wrapped up by envelope rotation. (3) Finally, even at ∼2.''5 resolution we see the so-called polarization hole effect, where the fractional polarization drops significantly near the total intensity peak. All data are publicly available in the electronic edition of this article.

  10. Evaluation of hot forming effects mapping for CAE analyses

    Science.gov (United States)

    Knoerr, L.; Faath, T.; Dykeman, J.; Malcolm, S.

    2016-08-01

    Hot forming has grown significantly in the manufacturing of structural components within the vehicle Body-In-White construction. The superior strength of press hardened steels not only guarantee high resistance to deformation, it also brings a significant weight saving compared to conventional cold formed products. However, the benefit of achieving ultrahigh strength with hot stamping, comes with a reduction in ductility of the press hardened part. This will require advanced material modeling to capture the predicted performances accurately. A technique to optically measure and map the thinning distribution after hot stamping has shown to improve numerical analysis for fracture prediction. The proposed method to determine the forming effects and mapping to CAE models can be integrated into the Vehicle Development Process to shorten the time to production.

  11. Preliminary evaluation of alternative waste form solidification processes. Volume II. Evaluation of the processes

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    This Volume II presents engineering feasibility evaluations of the eleven processes for solidification of nuclear high-level liquid wastes (HHLW) described in Volume I of this report. Each evaluation was based in a systematic assessment of the process in respect to six principal evaluation criteria: complexity of process; state of development; safety; process requirements; development work required; and facility requirements. The principal criteria were further subdivided into a total of 22 subcriteria, each of which was assigned a weight. Each process was then assigned a figure of merit, on a scale of 1 to 10, for each of the subcriteria. A total rating was obtained for each process by summing the products of the subcriteria ratings and the subcriteria weights. The evaluations were based on the process descriptions presented in Volume I of this report, supplemented by information obtained from the literature, including publications by the originators of the various processes. Waste form properties were, in general, not evaluated. This document describes the approach which was taken, the developent and application of the rating criteria and subcriteria, and the evaluation results. A series of appendices set forth summary descriptions of the processes and the ratings, together with the complete numerical ratings assigned; two appendices present further technical details on the rating process.

  12. Evaluation of metrology technologies for free form surfaces

    DEFF Research Database (Denmark)

    Arámbula, K.; Siller, H.R.; De Chiffre, Leonardo

    2012-01-01

    This research work describes a novel approach for comparing different technologies for free form surface metrology: computerized tomography (CT), photogrammetry and coordinate measuring machines (CMM). The comparison has the aim of providing relevant information for the selection of metrology...... also deals with costs issues, required standards, and necessary additional information when selecting inspection equipment....

  13. Evaluation of metrology technologies for free form surfaces

    DEFF Research Database (Denmark)

    Arámbula, K.; Siller, H.R.; De Chiffre, Leonardo

    2012-01-01

    This research work describes a novel approach for comparing different technologies for free form surface metrology: computerized tomography (CT), photogrammetry and coordinate measuring machines (CMM). The comparison has the aim of providing relevant information for the selection of metrology...... also deals with costs issues, required standards, and necessary additional information when selecting inspection equipment....

  14. Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores

    OpenAIRE

    2010-01-01

    The objective of the present study was to investigate the effect of the pellet core materials isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustained-release pellets as well as to evaluate the influence of different ratios of polymethacrylate copolymers exhibiting different permeability characteristics on the drug release rate. For characterization of the drug release process of pellets, the effect of osmolality was studied using glucose as an ...

  15. Benchmark Evaluation of the HTR-PROTEUS Absorber Rod Worths (Core 4)

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess; Leland M. Montierth

    2014-06-01

    PROTEUS was a zero-power research reactor at the Paul Scherrer Institute (PSI) in Switzerland. The critical assembly was constructed from a large graphite annulus surrounding a central cylindrical cavity. Various experimental programs were investigated in PROTEUS; during the years 1992 through 1996, it was configured as a pebble-bed reactor and designated HTR-PROTEUS. Various critical configurations were assembled with each accompanied by an assortment of reactor physics experiments including differential and integral absorber rod measurements, kinetics, reaction rate distributions, water ingress effects, and small sample reactivity effects [1]. Four benchmark reports were previously prepared and included in the March 2013 edition of the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook) [2] evaluating eleven critical configurations. A summary of that effort was previously provided [3] and an analysis of absorber rod worth measurements for Cores 9 and 10 have been performed prior to this analysis and included in PROTEUS-GCR-EXP-004 [4]. In the current benchmark effort, absorber rod worths measured for Core Configuration 4, which was the only core with a randomly-packed pebble loading, have been evaluated for inclusion as a revision to the HTR-PROTEUS benchmark report PROTEUS-GCR-EXP-002.

  16. Aeromonas spp.: evaluation of genomic diversity and biofilm forming ability

    OpenAIRE

    Craveiro, Sara Sofia Pereira, 1986-

    2013-01-01

    Tese de mestrado. Biologia (Microbiologia Aplicada). Universidade de Lisboa, Faculdade de Ciências, 2013 Aeromonas spp. are ubiquitous bacteria widely distributed among aquatic environments. Their persistence in water distribution systems is related to their ability to form biofilms, even in the presence of residual chlorine. Once in distribution water systems, aeromonads can contaminate drinking water, food processing facilities and food products. Moreover, members of this genus are known...

  17. PROCESS SIMULATION AND QUALITY EVALUATION IN INCREMENTAL SHEET FORMING

    Directory of Open Access Journals (Sweden)

    Meftah Hrairi

    2011-12-01

    Full Text Available Single Point Incremental Forming (SPIF is a promising sheet-metal-forming process that permits the manufacturing of small to medium-sized batches of complex parts at low cost. It allows metal forming to work in the critical ‘necking-to-tearing' zone which results in a strong thinning before failure if the process is well designed. Moreover, the process is complex due to the number of variables involved. Thus, it is not possible to consider that the process has been well assessed; several remaining aspects need to be clarified. The objective of the present paper is to study some of these aspects, namely, the phenomenon of the wall thickness overstretch along depth and the effect of the tool path on the distribution of the wall thickness using finite element simulations.Abstrak: Pembentukan Tokokan Mata Tunggal (Single Point Incremental Forming (SPIF merupakan satu proses pembentukan kepingan logam yang membolehkan pembuatan dalam jumlah yang kecil hingga sederhana, bahagian-bahagian yang kompleks pada kos yang rendah. Jika proses ini direka dengan baik, kaedah ini membolehkan pembentukan logam yang baik terhasil. Jika tidak, semasa peringkat zon kritikal ‘perleheran-ke-pengoyakan' menyebabkan penipisan keterlaluan yang boleh menyebabkan logam tersebut rosak. Tambahan pula, proses ini agak kompleks, kerana ia melibatkan beberapa pemboleh ubah. Maka, walaupun proses ini telah dinilaikan seeloknya; masih terdapat beberapa aspek lain yang perlu diperjelaskan. Objektif kertas ini dibentangkan adalah untuk mengkaji beberapa aspek tertentu, seperti, ketebalan dinding regangan berlebihan di sepanjang kedalaman dan kesan tool path (beberapa siri posisi koordinat untuk menentukan pergerakan alatan memotong ketika operasi memesin terhadap pengagihan ketebalan dinding menggunakan simulasi unsur terhingga.

  18. Evaluation of the Heat, Entropy, and Rotational Changes Produced by Gravitational Segregation during Core Formation

    Institute of Scientific and Technical Information of China (English)

    Anne M. Hofmeister; Robert E. Criss

    2015-01-01

    Core formation by gravitational segregation allegedly released sufficient interior heat to melt the Earth. Analysis of the energetics, which compare gravitational potential energy (Ug) of a fictitious, homogeneous reference state to Earth’s current layered configuration, needs updating to correct errors and omissions, and to accommodate recent findings: (1) An erroneous positive sign was used for Ug while maintaining the reference value of 0 at infinity, which results in an incorrect sign for ΔUg, which is crucial in determining whether a process is endothermic or exothermic. (2) The value of Ug for Earth’s initial state is uncertain. (3) Recent meteorite evidence indicates that core formation began before the Earth was full-sized, which severely limitsDUg. (4) Inhomogeneous accretion additionally reducedDUg. (5) The potentially large effect of differential rotation between the core and the mantle was not accounted for. (6) Entropy changes associated with creating order were neglected. Accordingly, we revise values of Ug, evaluate uncertainties, and show thatDUg was converted substantially to configurational energy (TDS). These considerations limit the large sources of primordial heat to impacts and radioactivity. Although these processes may play a role in core formation, their energies are independent of gravitational segregation, which produces order and rotational energy, not internal heat. Instead, gravitational segregation promotes planetary cooling mainly because it segregates lithophilic radioactive elements upward, increasing surface heat flux while shortening the distance over which radiogenic heat diffuses outwards.

  19. Evaluation of soft-core processors on a Xilinx Virtex-5 field programmable gate array.

    Energy Technology Data Exchange (ETDEWEB)

    Learn, Mark Walter

    2011-04-01

    Node-based architecture (NBA) designs for future satellite projects hold the promise of decreasing system development time and costs, size, weight, and power and positioning the laboratory to address other emerging mission opportunities quickly. Reconfigurable field programmable gate array (FPGA)-based modules will comprise the core of several of the NBA nodes. Microprocessing capabilities will be necessary with varying degrees of mission-specific performance requirements on these nodes. To enable the flexibility of these reconfigurable nodes, it is advantageous to incorporate the microprocessor into the FPGA itself, either as a hard-core processor built into the FPGA or as a soft-core processor built out of FPGA elements. This document describes the evaluation of three reconfigurable FPGA-based soft-core processors for use in future NBA systems: the MicroBlaze (uB), the open-source Leon3, and the licensed Leon3. Two standard performance benchmark applications were developed for each processor. The first, Dhrystone, is a fixed-point operation metric. The second, Whetstone, is a floating-point operation metric. Several trials were run at varying code locations, loop counts, processor speeds, and cache configurations. FPGA resource utilization was recorded for each configuration.

  20. Childhood Obesity Risk Evaluation based on perinatal factors and family sociodemographic characteristics: CORE index.

    Science.gov (United States)

    Manios, Yannis; Birbilis, Manolis; Moschonis, George; Birbilis, George; Mougios, Vassilis; Lionis, Christos; Chrousos, George P

    2013-04-01

    The aim of this study was to develop an index that estimates late childhood obesity risk based on certain perinatal and family sociodemographic characteristics. The study was cross-sectional with retrospectively collected data from a representative sample of 2,294 primary schoolchildren, aged 9-13 years, in four counties from north, west, central, and south Greece. Mother's prepregnancy weight status, maternal smoking during pregnancy, maternal educational level, and infant weight gain in the first 6 months of life were combined with children's gender for the development of the Childhood Obesity Risk Evaluation (CORE) index. The score of the CORE index ranged from 0 to 11 units and each unit was associated with an obesity risk probability (range, 4-40 %). Cutoff point analysis revealed that a score ≤ 5 units best discriminated obese from non-obese children. On the basis of this cutoff point, the sensitivity of the CORE index was 54 % and the corresponding specificity 65 %. The proposed CORE index and the relevant percent risk probability chart could be used by pediatricians and other health professionals to identify children at high risk for obesity from early life. This simple and inexpensive tool could be useful in assisting early childhood obesity preventing initiatives.

  1. Constitution of the forest road evaluation form for Turkish forestry

    African Journals Online (AJOL)

    STORAGESEVER

    2009-10-19

    Oct 19, 2009 ... wild habitats 5.63%; eligibility for forestry works 2.64% and eligibility for utilization for security 6.45%. The evaluation ... establishment and maintenance of forest road networks. However ..... J. Civil Eng. 33: 58-68. Forman EH ...

  2. Leasing versus Borrowing: Evaluating Alternative Forms of Consumer Credit.

    Science.gov (United States)

    Nunnally, Bennie H., Jr.; Plath, D. Anthony

    1989-01-01

    Presents a straightforward method for evaluating lease versus borrow (buy) decisions illustrated with actual financing cost data reported to new car purchasers. States that individuals should consider after-tax cash flows associated with alternative arrangements, time in which cash flow occurs, and opportunity cost of capital to identify the least…

  3. Re-evaluating the 1257 AD eruption using annually-resolved ice core chemical analyses

    Science.gov (United States)

    Simonsen, M. F.; Kjær, H. A.; Vallelonga, P. T.; Neff, P. D.; Bertler, N. A. N.; Svensson, A.; Seierstad, I.; Albert, P. G.; Bourne, A. J.; Kurbatov, A.

    2014-12-01

    The source of the 1257 AD volcanic eruption has recently been proposed to be Samalas in Indonesia. The eruption was one of the largest of the Holocene and has been recorded in ice cores in both hemispheres from sulfate and acidity measurements. The estimate of its sulfate load varies from 2 to 8 times that of Tambora. This is also the only volcano for which tephras have been assigned in ice cores from both Antarctica and Greenland (GISP2). Due to this unique assignment of a bipolar tephra layer in ice cores, the origins of the sulfate and tephras have been disputed and it has been proposed that at least one of the tephras was due to an additional volcanic eruption local to either Greenland or Antarctica. We have re-evaluated the acid and tephra deposition from the 1257 AD volcano in two ice cores, one from Greenland (NGRIP. 75.1° N, 42.3° W) and one from Antarctica (RICE, Roosevelt Island. 79.36° S, -161.71° W). Annually-resolved continuous flow analysis (CFA) measurements determined relevant parameters such as melt water conductivity, sulphate and acidity. The acidity peak at RICE (~20 uM H+) is approximately double that found at NGRIP (10 uM H+). The only visible tephra layer found in the corresponding depth range was deposited at 1250 AD, 9 years before the acidity peak. The high resolution of the data offers a precise evaluation of the delay between the deposition of tephra and acid (sulfate) in each hemisphere. The comparison between poles allows some evaluation of the spread of deposition from the volcanic eruption.

  4. An evaluation of sodium void reactivity for metal fuel FBR cores

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, Hirokazu; Yokoo, Takeshi [Central Research Inst. of Electric Power Industry, Komae, Tokyo (Japan). Komae Research Lab

    2000-07-01

    The sodium void reactivity in metal fuel FBR cores has been evaluated by a detailed method which takes into account the neutron streaming effects in the fuel subassemblies and the neutron transport corrections in whole-core systems. The neutron streaming effects caused by the heterogeneity of the fuel element structure or the coolant paths were evaluated on the basis of Benoist's anisotropic diffusion coefficient. We clarified that the sodium void reactivity is worth less than $8, even in the 1,000 MWe or 1,500 MWe-class large-scale cores. Further, we also found that, in the case of 1,500 MWe metal fuel FBRs recycling a few percent of minor actinide elements (MA), the sodium void reactivity does not exceed $10 with a suitable design that eliminates the upper and lower axial blankets. These results show that these metal fuel FBRs satisfy the safety criterion ($8-10) for avoiding the prompt criticality in the HCDA events. However, MA enrichment should be controlled to less than about two per cent, when the axial blanket is loaded to gain higher breeding performance. (author)

  5. The core self-evaluation scale: psychometric properties of the german version in a representative sample.

    Science.gov (United States)

    Zenger, Markus; Körner, Annett; Maier, Günter W; Hinz, Andreas; Stöbel-Richter, Yve; Brähler, Elmar; Hilbert, Anja

    2015-01-01

    The Core Self-Evaluation Scale (CSES) is an economical self-reporting instrument that assesses fundamental evaluations of self-worthiness and capabilities. The broad aims of this study were to test the CSES's psychometric properties. The study is based on a representative survey of the German general population. Confirmatory factor analyses were conducted for different models with 1, 2, and 4 latent factors. The CSES was found to be reliable and valid, as it correlated as expected with measures of depression, anxiety, quality of life, self-report health status, and pain. A 2-factor model with 2 related factors (r = -.62) showed the best model fit. Furthermore, the CSES was measurement invariant across gender and age. In general, males had higher values of positive self-evaluations and lower negative self-evaluations than females. It is concluded that the CSES is a useful tool for assessing resource-oriented personality constructs.

  6. 48 CFR 247.372 - DD Form 1654, Evaluation of Transportation Cost Factors.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false DD Form 1654, Evaluation... Transportation in Supply Contracts 247.372 DD Form 1654, Evaluation of Transportation Cost Factors. Contracting personnel may use the DD Form 1654 to furnish information to the transportation office for development...

  7. Evaluation of the film-forming property of hydrogenated rosin.

    Science.gov (United States)

    Satturwar, P M; Fulzele, S V; Joshi, S B; Dorle, A K

    2003-09-01

    The film-forming and coating properties of a new biomaterial, hydrogenated rosin (HR), is investigated in the present communication. Films produced by casting method are studied for mechanical, (tensile strength, elongation, and Young's modulus), water vapor transmission, and moisture absorption characteristics. Type of plasticizer and its concentration were observed to play an important role in modifying the film characteristics. Dibutyl sebacate (DBS), a hydrophobic plasticizer, was found to be suitable for development of flexible and smooth films. Film formulations plasticized with DBS were investigated for coating the drug layered nonpareil seeds where plasticization facilitated development of smooth and uniformly coated pellets. The increase in coat buildup, however, did not sustain the drug release significantly. The studies conclude that HR films promise utility as moisture-protective hydrophobic, film-coating materials.

  8. Institute of Medicine core competencies as a foundation for nursing program evaluation.

    Science.gov (United States)

    Morris, Tama L; Hancock, Dawson R

    2013-01-01

    The purpose of this case study was to explore one institution's experience integrating the Institute of Medicine (IOM) competencies into a pre-licensure baccalaureate nursing curriculum. In response to a growing number of errors in the health care system and efforts to increase patient safety and quality of care, the IOM proposed that students in health care professions learn to implement five core competencies. The program evaluation encompassed a mixed-method, stakeholder-focused methodology using a curriculum matrix triangulated with Student and Faculty Core Competency surveys. Results of the study indicate that all competencies were evident in the curriculum. Students often cited barriers to implementation of the competencies while faculty cited opportunities. Findings suggest that faculty need to raise student awareness of performing the competencies and be deliberate in the design of experiences to facilitate competency implementation.

  9. Evaluation of the Leon3 soft-core processor within a Xilinx radiation-hardened field-programmable gate array.

    Energy Technology Data Exchange (ETDEWEB)

    Learn, Mark Walter

    2012-01-01

    The purpose of this document is to summarize the work done to evaluate the performance of the Leon3 soft-core processor in a radiation environment while instantiated in a radiation-hardened static random-access memory based field-programmable gate array. This evaluation will look at the differences between two soft-core processors: the open-source Leon3 core and the fault-tolerant Leon3 core. Radiation testing of these two cores was conducted at the Texas A&M University Cyclotron facility and Lawrence Berkeley National Laboratory. The results of these tests are included within the report along with designs intended to improve the mitigation of the open-source Leon3. The test setup used for evaluating both versions of the Leon3 is also included within this document.

  10. Spectrophotometric Evaluation of Polyetheretherketone (PEEK as a Core Material and a Comparison with Gold Standard Core Materials

    Directory of Open Access Journals (Sweden)

    Bogna Stawarczyk

    2016-06-01

    Full Text Available This study investigated the colorimetric properties of different veneering materials on core materials. Standardized specimens (10 mm × 10 mm × 1.5 mm reflecting four core (polyetheretherketone (PEEK, zirconia (ZrO2, cobalt–chromium–molybdenum alloy (CoCrMo, and titanium oxide (TiO2; thickness: 1.5 mm and veneering materials (VITA Mark II, IPS e.max CAD, LAVA Ultimate and VITA Enamic, all in shade A3; thickness: 0.5, 1.0, 1.5 and 2 mm, respectively were fabricated. Specimens were superimposed to assemblies, and the color was determined with a spectrophotometer (CieLab-System or a chair-side color measurement device (VITA EasyShade, respectively. Data were analyzed using three-, two-, and one-way ANOVA, a Chi2-test, and a Wilson approach (p < 0.05. The measurements with EasyShade showed A2 for VITA Mark II, A3.5 for VITA Enamic, B2 for LAVA Ultimate, and B3 for IPS e.max CAD. LabE-values showed significant differences between the tested veneering materials (p < 0.001. CieLab-System and VITA EasyShade parameters of the different assemblies showed a significant impact of core (p < 0.001, veneering material (p < 0.001, and thickness of the veneering material (p < 0.001. PEEK as core material showed comparable outcomes as compared to ZrO2 and CoCrMo, with respect to CieLab-System parameters for each veneering material. The relative frequency of the measured VITA EasyShade parameters regarding PEEK cores also showed comparable results as compared to the gold standard CoCrMo, regardless of the veneering material used.

  11. Subjective Evaluation of Forms in an Immersive Environment

    CERN Document Server

    Petiot, Jean-François

    2003-01-01

    User's perception of product, by essence subjective, is a major topic in marketing and industrial design. Many methods, based on users' tests, are used so as to characterise this perception. We are interested in three main methods: multidimensional scaling, semantic differential method, and preference mapping. These methods are used to built a perceptual space, in order to position the new product, to specify requirements by the study of user's preferences, to evaluate some product attributes, related in particular to style (aesthetic). These early stages of the design are primordial for a good orientation of the project. In parallel, virtual reality tools and interfaces are more and more efficient for suggesting to the user complex feelings, and creating in this way various levels of perceptions. In this article, we present on an example the use of multidimensional scaling, semantic differential method and preference mapping for the subjective assessment of virtual products. These products, which geometrical...

  12. Formulation and evaluation of gastroretentive dosage forms of Clarithromycin.

    Science.gov (United States)

    Nama, Muralidhar; Gonugunta, Chandra Sekhar Rao; Reddy Veerareddy, Prabhakar

    2008-01-01

    The purpose of this research was to develop the hydrodynamically balanced delivery system of Clarithromycin (CLA) which, after oral administration should have the ability to prolong gastric residence time with the desired in vitro release profile for the localized action in the stomach, in the treatment of Helicobacter pylori (H.pylori) mediated peptic ulcer. By applying wet granulation technique floating tablets of Clarithromycin were prepared. The proportion of sodium bicarbonate was varied to get the least possible lag time, also the polymer part varied to get the desired release. In vivo radiographic studies were performed with Barium sulphate loaded formulation to justify the increased gastric residence time of the dosage form in the stomach, based on the floating principle. The formulation developed using 66.2% Clarithromycin, 12% HPMC K4M polymer, 8% sodium bicarbonate gave floating lag time less than 3 min with a floating time of 12 h, and an in vitro release profile very near to the desired release. X-ray studies showed the enhanced gastric residence time of the tablet to 220 +/- 30 min. The mechanism of release of Clarithromycin from the floating tablets is anomalous diffusion transport and follows zero order kinetics. In vivo radiographic studies suggest that the tablet has increased gastric residence time for the effective localized action of the antibiotic (Clarithromycin) in the treatment of H.pylori mediated peptic ulcer.

  13. Adaptation of adhesive post and cores to dentin after in vitro occlusal loading: evaluation of post material influence

    OpenAIRE

    Dietschi, Didier; Ardu, Stefano; Rossier-Gerber, Anne; Krejci, Ivo

    2006-01-01

    Fatigue resistance of post and cores is critical to the long term behavior of restored nonvital teeth. The purpose of this in vitro trial was to evaluate the influence of the post material's physical properties on the adaptation of adhesive post and core restorations after cyclic mechanical loading.

  14. Least squares evaluations for form and profile errors of ellipse using coordinate data

    Science.gov (United States)

    Liu, Fei; Xu, Guanghua; Liang, Lin; Zhang, Qing; Liu, Dan

    2016-09-01

    To improve the measurement and evaluation of form error of an elliptic section, an evaluation method based on least squares fitting is investigated to analyze the form and profile errors of an ellipse using coordinate data. Two error indicators for defining ellipticity are discussed, namely the form error and the profile error, and the difference between both is considered as the main parameter for evaluating machining quality of surface and profile. Because the form error and the profile error rely on different evaluation benchmarks, the major axis and the foci rather than the centre of an ellipse are used as the evaluation benchmarks and can accurately evaluate a tolerance range with the separated form error and profile error of workpiece. Additionally, an evaluation program based on the LS model is developed to extract the form error and the profile error of the elliptic section, which is well suited for separating the two errors by a standard program. Finally, the evaluation method about the form and profile errors of the ellipse is applied to the measurement of skirt line of the piston, and results indicate the effectiveness of the evaluation. This approach provides the new evaluation indicators for the measurement of form and profile errors of ellipse, which is found to have better accuracy and can thus be used to solve the difficult of the measurement and evaluation of the piston in industrial production.

  15. Core self-evaluations and Snyder's hope theory in persons with spinal cord injuries.

    Science.gov (United States)

    Smedema, Susan Miller; Chan, Jacob Yuichung; Phillips, Brian N

    2014-11-01

    The objective of the study was to evaluate a motivational model of core self-evaluations (CSE), hope (agency and pathways thinking), participation, and life satisfaction in persons with spinal cord injuries. A cross-sectional, correlational design with path analysis was used to evaluate the model. 187 adults with spinal cord injuries participated in this study. The results indicated an excellent fit between the data and the proposed model. Specifically, CSE was found to directly predict agency and pathways thinking, participation, and life satisfaction. CSE was also found to indirectly predict participation and life satisfaction through agency thinking. Although CSE contributes directly to participation and life satisfaction, it also has a unique role in increasing individuals' motivation to pursue goals, which also predicts participation and life satisfaction. Counseling interventions should be multifaceted and address the components of CSE to increase hope, participation, and life satisfaction. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  16. BENCHMARK EVALUATION OF THE START-UP CORE REACTOR PHYSICS MEASUREMENTS OF THE HIGH TEMPERATURE ENGINEERING TEST REACTOR

    Energy Technology Data Exchange (ETDEWEB)

    John Darrell Bess

    2010-05-01

    The benchmark evaluation of the start-up core reactor physics measurements performed with Japan’s High Temperature Engineering Test Reactor, in support of the Next Generation Nuclear Plant Project and Very High Temperature Reactor Program activities at the Idaho National Laboratory, has been completed. The evaluation was performed using MCNP5 with ENDF/B-VII.0 nuclear data libraries and according to guidelines provided for inclusion in the International Reactor Physics Experiment Evaluation Project Handbook. Results provided include updated evaluation of the initial six critical core configurations (five annular and one fully-loaded). The calculated keff eigenvalues agree within 1s of the benchmark values. Reactor physics measurements that were evaluated include reactivity effects measurements such as excess reactivity during the core loading process and shutdown margins for the fully-loaded core, four isothermal temperature reactivity coefficient measurements for the fully-loaded core, and axial reaction rate measurements in the instrumentation columns of three core configurations. The calculated values agree well with the benchmark experiment measurements. Fully subcritical and warm critical configurations of the fully-loaded core were also assessed. The calculated keff eigenvalues for these two configurations also agree within 1s of the benchmark values. The reactor physics measurement data can be used in the validation and design development of future High Temperature Gas-cooled Reactor systems.

  17. Spectrophotometric Evaluation of Polyetheretherketone (PEEK) as a Core Material and a Comparison with Gold Standard Core Materials.

    Science.gov (United States)

    Stawarczyk, Bogna; Schmid, Philipp; Roos, Malgorzata; Eichberger, Marlis; Schmidlin, Patrick R

    2016-06-20

    This study investigated the colorimetric properties of different veneering materials on core materials. Standardized specimens (10 mm × 10 mm × 1.5 mm) reflecting four core (polyetheretherketone (PEEK), zirconia (ZrO₂), cobalt-chromium-molybdenum alloy (CoCrMo), and titanium oxide (TiO₂); thickness: 1.5 mm) and veneering materials (VITA Mark II, IPS e.max CAD, LAVA Ultimate and VITA Enamic, all in shade A3; thickness: 0.5, 1.0, 1.5 and 2 mm, respectively) were fabricated. Specimens were superimposed to assemblies, and the color was determined with a spectrophotometer (CieLab-System) or a chair-side color measurement device (VITA EasyShade), respectively. Data were analyzed using three-, two-, and one-way ANOVA, a Chi²-test, and a Wilson approach (p materials (p material (p material (p material showed comparable outcomes as compared to ZrO₂ and CoCrMo, with respect to CieLab-System parameters for each veneering material. The relative frequency of the measured VITA EasyShade parameters regarding PEEK cores also showed comparable results as compared to the gold standard CoCrMo, regardless of the veneering material used.

  18. [Self-evaluation of core competencies and related factors among baccalaureate nursing students].

    Science.gov (United States)

    Wu, Chen-Ting; Hsieh, Suh-Ing; Hsu, Li-Ling

    2013-02-01

    Evaluations of higher education programs are increasingly centered on the learner and designed to assess learning effectiveness and core competencies. Although the Taiwan Nursing Accreditation Council (TNAC) has established eight core competencies for college nursing departments, little research has been done to identify the most salient contributors to undergraduate nursing students' perceived competency levels. This paper investigates the influence of student demographic factors and learning experience on students' development in terms of a selected sample of core nursing competencies and then identifies factors that significantly predicts such development. This is a cross-sectional descriptive correlational study. We collected data from a sample of freshmen students currently enrolled in a two-year nursing bachelor degree program at a private vocational university in Taipei, Taiwan. Participants self-assessed abilities in designated core nursing competencies using the Competency Inventory of Nursing Students (CINS). A total of 279 of 290 distributed questionnaires were returned and used in data collection, giving this study a valid return rate of 96.2%. Participants earned a mean CINS score of 5.23 (SD = 0.49). Scale dimensions from highest to lowest mean score rank were: ethics, accountability, caring spirit, communication and cooperation, lifelong learning, general clinical nursing skills, critical thinking, and basic biomedical science. Differentiated analysis revealed that nursing students who expressed a strong interest in nursing, had a clear career plan, held aspirations to pursue higher nursing education, designated "major hospital" as their first workplace of choice, designated a post-college department / workplace preference, had participated in campus activities, were outspoken in classroom discussions and debates, made consistent effort to complete homework assignments and prepare for examinations, and performed relatively strong academically earned

  19. A core curriculum for international health: evaluating ten years' experience at the University of Arizona.

    Science.gov (United States)

    Pust, R E; Moher, S P

    1992-02-01

    215 graduates (118 women and 97 men) of the University of Arizona's International Health Core Curriculum received a questionnaire after completion of their clinical practice in order to evaluate the experience of 10 years from 1982-91. The curriculum consisted of a 3- week orientation course given to 4th year medical students with core contents of population, nutrition, and infectious diseases followed up by student evaluation upon completion. 192 students were eligible for the survey of whom 154 completed it yielding an 80% response rate: 139 future physicians and 15 nurses, health educators, and nutritionists. 113 of 154 respondents completed an international health field experience after the course in 43 developing countries: 22% in Africa, 39% in Asia-Pacific, and 39% in Latin American-Caribbean. 79% were in rural and 34% in urban areas. A public health-community medicine program was incorporated in the clinical work at most sites. 95% of them participated in clinical care, 73% in community teaching, and 51% in research and evaluation. The duration of this field experience lasted 6-12 months for 69% of them. The median responses regarding the possibility of postcourse international field work and rating the worth of the course for clinical care, teaching others, and research were well or very well. They also rated the preparation of the course for subsequent work at 43 specific sites as good and dealing with limited resources and cross-culture communication as very good. All were willing to recommend the course to their peers.

  20. Star Forming Dense Cloud Cores in the TeV -ray SNR RX J1713.7-3946

    Energy Technology Data Exchange (ETDEWEB)

    Sano, H.; Sato, J.; Yamamoto, H.; Hayakawa, T.; Torii, K.; Moribe, N.; Kawamura, A.; Okuda, T.; Mizuno, N.; Onishi, T.; Maezawa, H.; Inoue, T.; Inutsuka, S.; Tanaka, T.; Mizuno, A.; Ogawa, H.; Stutzki, J.; Bertoldi, F.; Anderl, S.; Bronfman, L.; Koo, B.C.

    2010-10-27

    RX J1713.7-3946 is one of the TeV {gamma}-ray supernova remnants (SNRs) emitting synchrotron X rays. The SNR is associated with molecular gas located at {approx}1 kpc. We made new molecular observations toward the dense cloud cores, peaks A, C and D, in the SNR in the {sup 12}CO(J=2-1) and {sup 13}CO(J=2-1) transitions at angular resolution of 90 degrees. The most intense core in {sup 13}CO, peak C, was also mapped in the {sup 12}CO(J=4-3) transition at angular resolution of 38 degrees. Peak C shows strong signs of active star formation including bipolar outflow and a far-infrared protostellar source and has a steep gradient with a r{sup -2.2 {+-} 0.4} variation in the average density within radius r. Peak C and the other dense cloud cores are rim-brightened in synchrotron X rays, suggesting that the dense cloud cores are embedded within or on the outer boundary of the SNR shell. This confirms the earlier suggestion that the X rays are physically associated with the molecular gas (Fukui et al. 2003). We present a scenario where the densest molecular core, peak C, survived against the blast wave and is now embedded within the SNR. Numerical simulations of the shock-cloud interaction indicate that a dense clump can indeed survive shock erosion, since shock propagation speed is stalled in the dense clump. Additionally, the shock-cloud interaction induces turbulence and magnetic field amplification around the dense clump that may facilitate particle acceleration in the lower-density inter-clump space leading to the enhanced synchrotron X rays around dense cores.

  1. Removal plan for Shippingport pressurized water reactor core 2 blanket fuel assemblies form T plant to the canister storage building

    Energy Technology Data Exchange (ETDEWEB)

    Lata

    1996-09-26

    This document presents the current strategy and path forward for removal of the Shippingport Pressurized Water Reactor Core 2 blanket fuel assemblies from their existing storage configuration (wet storage within the T Plant canyon) and transport to the Canister Storage Building (designed and managed by the Spent Nuclear Fuel. Division). The removal plan identifies all processes, equipment, facility interfaces, and documentation (safety, permitting, procedures, etc.) required to facilitate the PWR Core 2 assembly removal (from T Plant), transport (to the Canister storage Building), and storage to the Canister Storage Building. The plan also provides schedules, associated milestones, and cost estimates for all handling activities.

  2. Evaluation of B&W UO2/ThO2 VIII experimental core: criticality and thermal disadvantage factor analysis

    Energy Technology Data Exchange (ETDEWEB)

    Carlo Parisi; Emanuele Negrenti

    2017-02-01

    In the framework of the OECD/NEA International Reactor Physics Experiment (IRPHE) Project, an evaluation of core VIII of the Babcock & Wilcox (B&W) Spectral Shift Control Reactor (SSCR) critical experiment program was performed. The SSCR concept, moderated and cooled by a variable mixture of heavy and light water, envisaged changing of the thermal neutron spectrum during the operation to encourage breeding and to sustain the core criticality. Core VIII contained 2188 fuel rods with 93% enriched UO2-ThO2 fuel in a moderator mixture of heavy and light water. The criticality experiment and measurements of the thermal disadvantage factor were evaluated.

  3. Watt loss in three-phase transformers with circular and hexagonal forming contours of twisted spatial magnetic core rods

    Directory of Open Access Journals (Sweden)

    E.A. Avdieieva

    2014-04-01

    Full Text Available For spatial three-phase axial electromagnetic systems with circular and hexagonal cross-section configurations of twisted butt-end magnetic core rods, analytical dependences for optimal geometrical relations determination over the transformer minimum watt loss criterion are obtained, comparative analysis of the systems energy efficiency made.

  4. EXPERIMENTAL EVALUATION OF NUMERICAL MODELS TO REPRESENT THE STIFFNESS OF LAMINATED ROTOR CORES IN ELECTRICAL MACHINES

    Directory of Open Access Journals (Sweden)

    HIDERALDO L. V. SANTOS

    2013-08-01

    Full Text Available Usually, electrical machines have a metallic cylinder made up of a compacted stack of thin metal plates (referred as laminated core assembled with an interference fit on the shaft. The laminated structure is required to improve the electrical performance of the machine and, besides adding inertia, also enhances the stiffness of the system. Inadequate characterization of this element may lead to errors when assessing the dynamic behavior of the rotor. The aim of this work was therefore to evaluate three beam models used to represent the laminated core of rotating electrical machines. The following finite element beam models are analyzed: (i an “equivalent diameter model”, (ii an “unbranched model” and (iii a “branched model”. To validate the numerical models, experiments are performed with nine different electrical rotors so that the first non-rotating natural frequencies and corresponding vibration modes in a free-free support condition are obtained experimentally. The models are evaluated by comparing the natural frequencies and corresponding vibration mode shapes obtained experimentally with those obtained numerically. Finally, a critical discussion of the behavior of the beam models studied is presented. The results show that for the majority of the rotors tested, the “branched model” is the most suitable

  5. Evaluation of global synchronization for iterative algebra algorithms on many-core

    KAUST Repository

    ul Hasan Khan, Ayaz

    2015-06-01

    © 2015 IEEE. Massively parallel computing is applied extensively in various scientific and engineering domains. With the growing interest in many-core architectures and due to the lack of explicit support for inter-block synchronization specifically in GPUs, synchronization becomes necessary to minimize inter-block communication time. In this paper, we have proposed two new inter-block synchronization techniques: 1) Relaxed Synchronization, and 2) Block-Query Synchronization. These schemes are used in implementing numerical iterative solvers where computation/communication overlapping is one used optimization to enhance application performance. We have evaluated and analyzed the performance of the proposed synchronization techniques using Jacobi Iterative Solver in comparison to the state of the art inter-block lock-free synchronization techniques. We have achieved about 1-8% performance improvement in terms of execution time over lock-free synchronization depending on the problem size and the number of thread blocks. We have also evaluated the proposed algorithm on GPU and MIC architectures and obtained about 8-26% performance improvement over the barrier synchronization available in OpenMP programming environment depending on the problem size and number of cores used.

  6. Developing core competencies for monitoring and evaluation tracks in South Asian MPH programs.

    Science.gov (United States)

    Negandhi, Himanshu; Negandhi, Preeti; Tiwari, Ritika; Sharma, Anjali; Zodpey, Sanjay; Kulatilaka, Hemali; Tikyani, Sangeeta

    2015-08-05

    Monitoring and evaluation (M&E) provides vital information for decision-making and its structures, systems and processes are expected to be integrated throughout the life-cycle of public health programs. The acquisition of these skills should be developed in a structured manner and needs educational systems to identify core competencies in M&E teaching. This article presents our work on harmonizing M&E competencies for Masters level programs in the South Asian context and undertaking the global review of M&E track/ concentration offered in various Masters of Public Health (MPH) programs. Through an online search and snow-balling, we mapped institutions offering M&E tracks/ concentrations in Masters of Public Health (MPH) programs globally. We obtained detailed information about their M&E curriculum from university websites and brochures. The data on curricular contents was extracted and compiled. We analyzed the curricular contents using the framework for core competencies developed by the Association of Schools of Public Health (ASPH); and the Miller's triangle. This data was then used to inform a consultative exercise aimed at identifying core competencies for an M&E track/ concentration in MPH programs in the South Asian context. Our curricular review of M&E content within MPH programs globally showed that different domains or broad topic areas relating to M&E are covered differently across the programs. The quantitative sciences (Biostatistics and Epidemiology) and Health Policy and Management are covered in much greater depth than the other two domains (Social & Behavioral Sciences and Environmental Health Sciences). The identification of core competencies for an M&E track/ concentration in the South Asian context was undertaken through a consultative group exercise involving representation from 11 institutions across Bangladesh, India, Nepal and Sri Lanka. During the consultation, the group engaged in a focused discussion to reach consensus on a set of 15

  7. Evaluation of nuclear characteristics of DCA modification core for sub-critical measurement

    Energy Technology Data Exchange (ETDEWEB)

    Hazama, Taira [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1997-10-01

    Critical experiments were carried out on Deuterium Critical Assembly (DCA) modification core. DCA modification core has two regions, that is, test region and driver region. The test region consists of various types of fuel and moderator, while the driver region remains the same as the original DCA core (ATR simulated core). Critical characteristics were measured with various types of core patterns and were compared with calculated values based on SCALE code system. Monte Calro code KENO was found to be very accurate in the core analysis. The accuracy stays below 0.5 %dk/k in keff even if core configuration is extremely complicated. (author)

  8. Evaluation of an Observer Form of the Coping Inventory for Stressful Situations

    Science.gov (United States)

    Han, Kyunghee; Burns, Gary N.; Weed, Nathan C.; Hatchett, Gregory T.; Kurokawa, Nancy K. S.

    2009-01-01

    The present study evaluates a prospective observer form of the Coping Inventory for Stressful Situations (CISS) by comparing the two forms in terms of factor structure, mean differences, reliability, and examining correlations between self-report and peer ratings. A total of 163 pairs of friends complete the CISS and an observer form of the CISS.…

  9. Polymeric micelles based on poly(ethylene oxide) and α-carbon substituted poly(ɛ-caprolactone): An in vitro study on the effect of core forming block on polymeric micellar stability, biocompatibility, and immunogenicity.

    Science.gov (United States)

    Garg, Shyam M; Vakili, Mohammad Reza; Lavasanifar, Afsaneh

    2015-08-01

    A series of block copolymers based on methoxy poly(ethylene oxide)-block-poly(ɛ-caprolactone) (PEO-b-PCL), PEO-b-PCL bearing side groups of benzyl carboxylate (PEO-b-PBCL), or free carboxyl (PEO-b-PCCL) on the PCL backbone with increasing degrees of polymerization of the PCL backbone were synthesized. Prepared block copolymers assembled to polymeric micelles by co-solvent evaporation. The physical stability of prepared micelles was assessed by measuring their tendency toward aggregation over time using dynamic light scattering (DLS). The resistance of micelles against dissociation in the presence of a micelle destabilizing agent, i.e., sodium dodecyl sulfate (SDS), was also investigated using DLS. The rate of micellar core degradation was determined using (1)H NMR for polymer molecular weight measurement upon incubation of micelles in PBS (pH=7.4) at 37°C followed by dialysis of the remaining polymer at different time intervals. The effect of pendent group chemistry in the micellar core on the adsorption of serum proteins to micellar structure was then evaluated using Bradford Protein assay kit. Finally, the effect of micellar core structure on the induction of bone marrow derived dendritic cell (BMDC) maturation and secretion of IL-12 was studied as a measure of micellar immunogenicity. The results showed micelle structures from polymers with higher degree of polymerization in the hydrophobic block and/or those with more hydrophobic substituents on the core-forming block, to be more stable. This was reflected by a decreased tendency for micellar aggregation, reduced dissociation of micelles in the presence of SDS, and diminished core degradation. All micelles were shown to have insignificant adsorption of serum protein suggesting that the hydrophilic PEO shell provided sufficient protection of the core. However, the protein adsorption increased with increase in the hydrophobicity and molecular weight of the core-forming block. Irrespective of the micellar core

  10. A CORE approach to progress monitoring and feedback: Enhancing evidence and improving practice.

    Science.gov (United States)

    Barkham, Michael; Mellor-Clark, John; Stiles, William B

    2015-12-01

    This article describes the Clinical Outcomes in Routine Evaluation (CORE) System and reports on its scientific yield and practice impact. First, we describe the suite of CORE measures, including the centerpiece CORE-Outcome Measure (CORE-OM), its short forms, special purpose forms, translations, and psychometric properties, along with the pretreatment CORE Therapy Assessment Form and the CORE End of Therapy Form. Second, we provide an overview of the scientific yield arising from analyses of large CORE data sets collected in routine practice. Third, we describe the use of CORE measures for feedback in practice settings. Finally, we consider future directions for monitoring and feedback in research and practice.

  11. Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins.

    Science.gov (United States)

    Gao, Jian; Zhou, Zhifang; Guo, Jiatong; Guo, Zhongwu

    2017-06-06

    A convergent strategy was developed for the first-time synthesis of biotin-labeled GPI core glycans. These GPI conjugates are useful for various biological studies showcased by their application in the scrutiny of pore-forming bacterial toxin-GPI interaction, revealing that the phosphate group at the GPI inositol 1-O-position had a significant impact on GPI-toxin binding.

  12. Deuterium Burning in Massive Giant Planets and Low-Mass Brown Dwarfs formed by Core-Nucleated Accretion

    CERN Document Server

    Bodenheimer, Peter; Lissauer, Jack J; Fortney, Jonathan J; Saumon, Didier

    2013-01-01

    Formation of bodies near the deuterium-burning limit is considered by detailed numerical simulations according to the core-nucleated giant planet accretion scenario. The objects, with heavy-element cores in the range 5-30 Mearth, are assumed to accrete gas up to final masses of 10-15 Jupiter masses (Mjup). After the formation process, which lasts 1-5 Myr and which ends with a 'cold-start', low-entropy configuration, the bodies evolve at constant mass up to an age of several Gyr. Deuterium burning via proton capture is included in the calculation, and we determined the mass, M50, above which more than 50% of the initial deuterium is burned. This often-quoted borderline between giant planets and brown dwarfs is found to depend only slightly on parameters, such as core mass, stellar mass, formation location, solid surface density in the protoplanetary disk, disk viscosity, and dust opacity. The values for M50 fall in the range 11.6-13.6 Mjup, in agreement with previous determinations that do not take the formati...

  13. Evaluation of a conditioning method to improve core-veneer bond strength of zirconia restorations.

    Science.gov (United States)

    Teng, Jili; Wang, Hang; Liao, Yunmao; Liang, Xing

    2012-06-01

    The high strength and fracture toughness of zirconia have supported its extensive application in esthetic dentistry. However, the fracturing of veneering porcelains remains one of the primary causes of failure. The purpose of this study was to evaluate, with shear bond strength testing, the effect of a simple and novel surface conditioning method on the core-veneer bond strength of a zirconia ceramic system. The shear bond strength of a zirconia core ceramic to the corresponding veneering porcelain was tested by the Schmitz-Schulmeyer method. Thirty zirconia core specimens (10 × 5 × 5 mm) were layered with a veneering porcelain (5 × 3 × 3 mm). Three different surface conditioning methods were evaluated: polishing with up to 1200 grit silicon carbide paper under water cooling, airborne-particle abrasion with 110 μm alumina particles, and modification with zirconia powder coating before sintering. A metal ceramic system was used as a control group. All specimens were subjected to shear force in a universal testing machine at a crosshead speed of 0.5 mm/min. The shear bond strength values were analyzed with 1-way ANOVA and Tukey's post hoc pairwise comparisons (α=.05). The fractured specimens were examined with a scanning electron microscope to observe the failure mode. The mean (SD) shear bond strength values in MPa were 47.02 (6.4) for modified zirconia, 36.66 (8.6) for polished zirconia, 39.14 (6.5) for airborne-particle-abraded zirconia, and 46.12 (7.1) for the control group. The mean bond strength of the control (P=.028) and modified zirconia groups (P=.014) was significantly higher than that of the polished zirconia group. The airborne-particle-abraded group was not significantly different from any other group. Scanning electron microscopy evaluation showed that cohesive fracture in the veneering porcelain was the predominant failure mode of modified zirconia, while the other groups principally fractured at the interface. Modifying the zirconia surface

  14. Comparative evaluation of bond strengths of different core materials with various luting agents used for cast crown restorations.

    Science.gov (United States)

    Nayakar, Ramesh P; Patil, Narendra P; Lekha, K

    2012-09-01

    The coronal cast restoration continues to be used commonly to restore mutilated, endodontically treated teeth. The tensile bond strength of luting cements is of critical importance as many of failures are at the core and the crown interface. An invitro study with aim to evaluate and compare bond strengths of luting cements between different core materials and cast crowns. A total of 45 extracted identical mandibular second premolars were endodontically treated and divided into 3 groups of 15 each. Specimens in first group were restored with cast post and core (Group C), and specimens in second group were restored with stainless steel parapost and composite core material (Group B) and specimens in third group were restored with stainless steel parapost and glass ionomer core build (Group G). Standardized crown preparation was done for all the specimens to receive cast crowns. Each group was further divided into 3 subgroups and were cemented using 3 different luting cements namely, resin cement, polycarboxylate cement, glass ionomer cement (Type I). The samples of each subgroup (n = 5) were subjected to tensile testing using Universal Testing Machine at a crosshead speed of 2 mm/min till the dislodgement of crown from the core surface was observed. The bond strengths were significantly different according one way ANOVA (F-150.76 and p < 0.0000). The results of the study showed that the specimens cemented with resin cement in cast core, composite core and glass ionomer core exhibited significantly higher bond strengths as compared to specimens cemented with glass ionomer and polycarboxylate cement. Composite resin core and resin cement combinations were superior to all other cement and core combinations tested.

  15. Prescreening and efficiency in the evaluation of integrals over ab initio effective core potentials

    Science.gov (United States)

    Shaw, Robert A.; Hill, J. Grant

    2017-08-01

    New, efficient schemes for the prescreening and evaluation of integrals over effective core potentials (ECPs) are presented. The screening is shown to give a rigorous, and close bound, to within on average 10% of the true value. A systematic rescaling procedure is given to reduce this error to approximately 0.1%. This is then used to devise a numerically stable recursive integration routine that avoids expensive quadratures. Tests with coupled clusters with single and double excitations and perturbative triple calculations on small silver clusters demonstrate that the new schemes show no loss in accuracy, while reducing both the power and prefactor of the scaling with system size. In particular, speedups of roughly 40 times can be achieved compared to quadrature-based methods.

  16. Interaction of core self-evaluations and perceived organizational support on work-to-family enrichment.

    Science.gov (United States)

    McNall, Laurel A; Masuda, Aline D; Shanock, Linda Rhoades; Nicklin, Jessica M

    2011-01-01

    The purpose of this article was to offer an empirical test of J. H. Greenhaus and G. N. Powell's (2006) model of work-family enrichment by examining dispositional (i.e., core self-evaluations; CSEs) and situational (i.e., perceived organizational support; POS) factors associated with work-to-family enrichment (WFE) and whether these variables interact in predicting WFE. In a survey of 220 employed adults, our hierarchical regression analysis revealed that in highly supportive work environments, individuals reported high WFE regardless of CSE. However, when POS was low, individuals high in CSEs reported higher WFE than those low in CSEs, in support of conservation of resources theory (S. E. Hobfoll, 2002). Implications for research and practice are discussed.

  17. A Form Evaluation System and Its Data Structure for Brosh—Written Chinese Characters

    Institute of Scientific and Technical Information of China (English)

    曾建超; HidehikoSanada; 等

    1995-01-01

    A form evaluation system for brush-written Chinese characters is developed.Calligraphic knowledge used in the system is represented in the form of rules with the help of a data structure proposed in this paper.Reflecting the specific hierarchical relations among radicals and strokes of Chinese characters,the proposed data structure is based upon a character model that can generate brush-written Chinese characters on a computer.Through evaluation experiments using the developed system,it is shown that representation of calligraphic knowledge and form evaluation of Chinese characters can be smoothly realized if the data structure is utilized.

  18. 企业核心能力评价研究述评%Literature Review on Enterprises' Core Competence Evaluation

    Institute of Scientific and Technical Information of China (English)

    龚素芳

    2012-01-01

    Core competence evaluation is an important part of core competence research. How to properly and accurately evaluate the core competence of various types of enterprises in various industries is catching more and more attention. This paper summarizes the basic principles of core competence evaluation, sorts out the existing evaluation methods from the qualitative, quantitative standpoints as well as the combination of these two and further studies the status quo of core competence evaluation in real estate, high — tech and manufacturing businesses.%企业核心能力评价是核心能力研究的重要环节,如何恰当、准确地对不同行业、不同类型企业的核心能力进行评价获得了越来越多的关注.首先归纳了企业核心能力评价的基本原则,从定性、定量、定性定量相结合三方面对现有的评价方法进行梳理,并进一步考察了房地产企业、高新技术企业、制造企业的核心能力评价研究现状.

  19. An in vitro comparative evaluation of physical properties of four different types of core materials

    OpenAIRE

    2014-01-01

    Introduction: Compressive and tensile stresses of core materials are important properties because cores usually replace a large bulk of tooth structure and must resist multidirectional masticatory forces for many years. Material and Methods: The present study was undertaken to find out the best core build up material with respect to their physical properties among resin-based composites. Individual compressive, tensile, and flexural strength of fiber-reinforced dual cure resin core build...

  20. Organic chemistry of low-mass star-forming cores I: 7 mm spectroscopy of Chamaeleon MMS1

    CERN Document Server

    Cordiner, Martin A; Wirström, Eva S; Smith, Robert G

    2011-01-01

    Observations are presented of emission lines from organic molecules at frequencies 32 - 50 GHz in the vicinity of Chamaeleon MMS1. This chemically-rich dense cloud core habours an extremely young, very low-luminosity protostellar object and is a candidate first hydrostatic core. Column densities are derived and emission maps are presented for species including polyynes, cyanopolyynes, sulphuretted carbon-chains and methanol. The polyyne emission peak lies about 5000 AU from the protostar, whereas methanol peaks about 15,000 AU away. Averaged over the telescope beam, the molecular hydrogen number density is calculated to be 10^6 cm^-3 and the gas kinetic temperature is in the range 5 - 7 K. The abundances of long carbon chains are very large, and are indicative of a non-equilibrium carbon chemistry; C6H and HC7N column densities are 5.9 (+2.9 -1.3) \\times 10^11 cm^-2 and 3.3 (+8.0 -1.5) \\times 10^12 cm^-2, respectively, which are similar to the values found in the most carbon-chain-rich protostars and prestell...

  1. Core to College Evaluation: Statewide Networks. Connecting Education Systems and Stakeholders to Support College Readiness

    Science.gov (United States)

    Bracco, Kathy Reeves; Klarin, Becca; Broek, Marie; Austin, Kim; Finkelstein, Neal; Bugler, Daniel; Mundry, Susan

    2014-01-01

    The Core to College initiative aims to facilitate greater coordination between K-12 and postsecondary education systems around implementation of the Common Core State Standards and aligned assessments. Core to College grants have been awarded to teams in Colorado, Florida, Hawaii, Kentucky, Louisiana, Massachusetts, North Carolina, Oregon,…

  2. Alternating twist structures formed by electroconvection in the nematic phase of an achiral bent-core molecule.

    Science.gov (United States)

    Tanaka, Shingo; Dhara, Surajit; Sadashiva, B K; Shimbo, Yoshio; Takanishi, Yoichi; Araoka, Fumito; Ishikawa, Ken; Takezoe, Hideo

    2008-04-01

    We report an unusual electroconvection in the nematic phase of a bent-core liquid crystal. In a voltage-frequency diagram, two frequency regions exhibiting prewavy stripe patterns were found, as reported by Wiant We found that these stripes never show extinction dark when cells were rotated under crossed polarizers. Based on the color interchange in between neighboring stripes by the rotation of the cells or an analyzer, twisted molecular orientation is suggested; i.e., the directors are alternately twisted from the top to the bottom surfaces with a pretilt angle in adjacent stripes, which is an analogue of the twisted (splayed) structure observed in surface-stabilized ferroelectric liquid crystal cells. The transmittance spectra calculated using the 4x4 matrix method from the model structure are consistent with the experimental observation.

  3. Family incivility and job performance: a moderated mediation model of psychological distress and core self-evaluation.

    Science.gov (United States)

    Lim, Sandy; Tai, Kenneth

    2014-03-01

    This study extends the stress literature by exploring the relationship between family incivility and job performance. We examine whether psychological distress mediates the link between family incivility and job performance. We also investigate how core self-evaluation might moderate this mediated relationship. Data from a 2-wave study indicate that psychological distress mediates the relationship between family incivility and job performance. In addition, core self-evaluation moderates the relationship between family incivility and psychological distress but not the relationship between psychological distress and job performance. The results hold while controlling for general job stress, family-to-work conflict, and work-to-family conflict. The findings suggest that family incivility is linked to poor performance at work, and psychological distress and core self-evaluation are key mechanisms in the relationship.

  4. THE EFFECT OF SELF-SET GRADE GOALS AND CORE SELF-EVALUATIONS ON ACADEMIC PERFORMANCE: A DIARY STUDY.

    Science.gov (United States)

    Bipp, Tanja; Kleingeld, Ad; Van Den Tooren, Marieke; Schinkel, Sonja

    2015-12-01

    The aim of this diary study was to examine the effect of self-set grade goals and core self-evaluations on academic performance. Data were collected among 59 university students (M age = 18.4 yr., SD = 0.8) in a 2-wk. exam period on up to five exam days. Multilevel analyses revealed that the individual grade goals students set for their exams were positively related to the grades they obtained for these exams. However, the goal-performance relationship only applied to students scoring high on core self-evaluations. The results of this study contribute to the understanding of the effect of self-set grade goals and core self-evaluations on academic performance and imply important practical applications to enhance academic performance.

  5. The feasibility, reliability, and validity of a post-encounter form for evaluating clinical reasoning.

    NARCIS (Netherlands)

    Durning, S.J.; Artino, A.; Boulet, J.; Rochelle, J. La; Vleuten, C.P.M. van der; Arze, B.; Schuwirth, L.

    2012-01-01

    BACKGROUND: Developing feasible, reliable and valid methods for the evaluation of clinical reasoning is challenging. AIM: To explore feasibility, reliability, and validity evidence for a post-encounter form assessing clinical reasoning. METHOD: A free-text, post-encounter form was used in an Objecti

  6. Evaluation of Suppression of Hydroprocessed Renewable Jet (HRJ) Fuel Fires with Aqueous Film Forming Foam (AFFF)

    Science.gov (United States)

    2011-07-01

    AFRL-RX-TY-TR-2011-0101 EVALUATION OF SUPPRESSION OF HYDROPROCESSED RENEWABLE JET (HRJ) FUEL FIRES WITH AQUEOUS FILM FORMING FOAM ( AFFF ...Forming Foam ( AFFF ) has the capability of extinguishing HRJ fuel fires and HRJ/JP-8 blended fuel fires . The assessment included extinguishment...whether existing aqueous film- forming foam ( AFFF ) firefighting agents and equipment are capable of extinguishing alternative- fuel fires or

  7. [Fundamental and clinical evaluation of hepatitis B virus core-related antigen assay by LUMIPULSE f].

    Science.gov (United States)

    Tanaka, Yasuhito; Takagi, Kazumi; Hiramatsu, Kumiko; Naganuma, Hatsue; Iida, Takayasu; Takasaka, Yoshimitsu; Mizokami, Masashi

    2006-07-01

    A sensitive chemiluminescence enzyme immunoassay (CLEIA) has been developed for hepatitis B virus (HBV) core-related antigens (HBcrAg) detection. The HBcrAg is designated as the precore/core gene products including HBeAg. The aim of this study is to evaluate reproducibility of HBcrAg and correlation with HBV-DNA in serum using the automatic LUMIPULSE f to estimate an assay suitable for general laboratory use. In this study, we demonstrated that HBcrAg assay had highly intra-assay reproducible [coefficients of variation(CVs); 2.8-5.2%] and inter-assay reproducible [CVs; 3.9-9.1%]. When the cutoff value was tentatively set at 1 kU/ml, all healthy controls (HBsAg/HBV-DNA negative; n=100) and anti-HCV antibody-positive (n=50) sera were identified as negative. The assay showed a detection limit of 0.5 kU/ml using four serially diluted HBV high-titer sera, indicating higher sensitivity than HBV-DNA (transcription-mediated amplification). The HBcrAg concentration correlated positively with serum HBV-DNA (n=125, r = 0.860, p HBcrAg levels were higher in HBeAg-positive group than in HBeAg-negative group. In the natural course of HBV infection, the HBcrAg concentration usually changed in accordance with HBV-DNA levels, however during lamivudine therapy the change of HBcrAg was more gradual than that of HBV-DNA. In conclusion, HBcrAg concentration provides a reflection of HBV virus load equivalent to HBV-DNA level, and the assay therefore offers a simple method for monitoring hepatitis B patients.

  8. Using core competencies to build an evaluative framework: outcome assessment of the University of Guelph Master of Public Health program.

    Science.gov (United States)

    Britten, Nicole; Wallar, Lauren E; McEwen, Scott A; Papadopoulos, Andrew

    2014-07-31

    Master of Public Health programs have been developed across Canada in response to the need for graduate-level trained professionals to work in the public health sector. The University of Guelph recently conducted a five-year outcome assessment using the Core Competencies for Public Health in Canada as an evaluative framework to determine whether graduates are receiving adequate training, and identify areas for improvement. A curriculum map of core courses and an online survey of University of Guelph Master of Public Health graduates comprised the outcome assessment. The curriculum map was constructed by evaluating course outlines, assignments, and content to determine the extent to which the Core Competencies were covered in each course. Quantitative survey results were characterized using descriptive statistics. Qualitative survey results were analyzed to identify common themes and patterns in open-ended responses. The University of Guelph Master of Public Health program provided a positive learning environment in which graduates gained proficiency across the Core Competencies through core and elective courses, meaningful practicums, and competent faculty. Practice-based learning environments, particularly in collaboration with public health organizations, were deemed to be beneficial to students' learning experiences. The Core Competencies and graduate surveys can be used to conduct a meaningful and informative outcome assessment. We encourage other Master of Public Health programs to conduct their own outcome assessments using a similar framework, and disseminate these results in order to identify best practices and strengthen the Canadian graduate public health education system.

  9. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.

    Science.gov (United States)

    Fukuda, Mitsunori

    2003-04-25

    Slp4-a (synaptotagmin-like protein 4-a)/granuphilin-a is specifically localized on dense-core vesicles in PC12 cells and negatively controls dense-core vesicle exocytosis through specific interaction with Rab27A via the N-terminal Slp homology domain (SHD) (Fukuda, M., Kanno, E., Saegusa, C., Ogata, Y., and Kuroda, T. S. (2002) J. Biol. Chem. 277, 39673-39678). However, the mechanism of the inhibition by Slp4-a has never been elucidated at the molecular level and is still a matter of controversy. In this study, I discovered an unexpected biochemical property of Slp4-a, that Slp4-a, but not other Rab27 effectors reported thus far, is capable of interacting with both Rab27A(T23N), a dominant negative form that mimics the GDP-bound form, and Rab27A(Q78L), a dominant active form that mimics the GTP-bound form, whereas Slp4-a specifically recognizes the GTP-bound form of Rab3A and Rab8A and does not recognize their GDP-bound form. I show by deletion and mutation analyses that the TGDWFY sequence in SHD2 is essential for Rab27A(T23N) binding, whereas SHD1 is involved in Rab27A(Q78L) binding. I further show by immunoprecipitation and cotransfection assays that Munc18-1, but not syntaxin IA, directly interacts with the C-terminal domain of Slp4-a in a Rab27A-independent manner. Expression of Slp4-a mutants that lack Rab27A(T23N) binding activity (i.e. specific binding to Rab27A(Q78L)) completely reverses the inhibitory effect of the wild-type Slp4-a on high KCl-dependent neuropeptide Y secretion in PC12 cells. The results strongly indicate that interaction of Slp4-a with the GDP-bound form of Rab27A, not with syntaxin IA or Munc18-1, is the primary reason that Slp4-a expression inhibits dense core vesicle exocytosis in PC12 cells.

  10. The Components of Smile Design: New York University Smile Evaluation Form Revisited, Update 2015.

    Science.gov (United States)

    Calamia, John R; Wolff, Mark S

    2015-07-01

    This article updates a simple checklist of foundational knowledge in aesthetic dental concepts that allows clinicians to organize their thoughts, to record the concerns of the patient, and to map out those improvements that must be addressed. This adjunct is called a Smile Evaluation Form. Along with other adjuncts such as radiographs, study casts, and diagnostic wax-ups, the Smile Evaluation Form allows clinicians to form a conceptual visualization of the expected end point. It provides a checklist for discussions with other disciplines in the team, to provide a logical sequence of treatment with a mutually agreed-on end point.

  11. Evaluation Study of Core Competence of Higher Vocational College Library%高职院校图书馆核心竞争力评价研究

    Institute of Scientific and Technical Information of China (English)

    王涛

    2012-01-01

    紧密结合高职院校自身性质和发展特点,从高职院校图书馆核心竞争力内涵出发,提出高职院校图书馆核心竞争力评价指标体系,包括核心资源的配置、创新与开发能力、行业文化服务、团队文化塑造四大类指标,以期促进高职院校图书馆形成核心竞争力。%Based on the connotation of core competence of higher vocational college library and closely combining its own nature and development characteristics of higher vocational college,This paper puts forward evaluation index system of core competence,containing the configuration of core resource,the ability of innovation and development,the service of industry culture and the establishing of team culture,in order to make higher vocational college form the core competence.

  12. Submillimeter Array Observations of Magnetic Fields in G240.31+0.07: an Hourglass in a Massive Cluster-forming Core

    OpenAIRE

    Qiu, Keping; Zhang, Qizhou; Menten, Karl M.; Liu, Hauyu B.; Tang, Ya-Wen; Girart, Josep M.

    2014-01-01

    We report the first detection of an hourglass magnetic field aligned with a well-defined outflow-rotation system in a high-mass star-forming region. The observations were performed with Submillimeter Array toward G240.31+0.07, which harbors a massive, flattened, and fragmenting molecular cloud core and a wide-angle bipolar outflow. The polarized dust emission at 0.88 mm reveals a clear hourglass-shaped magnetic field aligned within 20 degree of the outflow axis. Maps of high-density tracing s...

  13. An evaluation of the metal fuel core performance for commercial FBR requirements

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, H.; Yokoo, T. [Central Research Inst. of Electric Power Industry, Komae, Tokyo (Japan)

    2001-07-01

    Neutronic and thermal hydraulic design studies are conducted on the 3,900 MWt and 800 MWt metal fuel fast breeder reactor (FBR) cores that achieve a high burnup of 150 GWd/t, which is considered to be one of the goals of future commercial FBRs. The results show that a large-scale metal fuel core with a homogeneous configuration is a promising design for future commercial FBRs from the view point of economics, core safety, effective use of uranium resources and reduction of environmental load. In small-scale high-burnup cores, a radial heterogeneous design that can improve neutronic performance and safety parameters is suitable. (author)

  14. Spontaneously formed interfacial metal silicates and their effect on the magnetism of superparamagnetic FeCo/SiO₂ core/shell nanoparticles.

    Science.gov (United States)

    Desautels, Ryan D; Rowe, Michael P; Jones, Michael; Whallen, Amanda; van Lierop, Johan

    2015-03-10

    The integration of superparamagnetic core/shell nanoparticles into devices and other nanoscale technological applications requires a detailed understanding of how the intimate contact between core and shell nanophases affects the magnetism. We report how, for single-domain FeCo nanoparticles, an FeCo phase unique to the nanoscale with silica shells of increasing thicknesses spontaneously formed interfacial metal silicates between the core and shell (such as Fe2SiO4 and Co2SiO4) and altered the overall magnetism of the nanomaterial significantly. The influence of this previously overlooked phenomenon on magnetic properties is reported. Evidence of these metal silicate interfacial layers was observed by X-ray absorption spectroscopy (XAS) collected over the L3,2 absorption edges of Fe and X-ray photoelectron spectra (XPS) collected over the 2p transitions of Fe and Co. Through the correlation of magnetometry and XPS data, the evolution of nanoparticle magnetic anisotropy is shown to increase with the metal silicate.

  15. The Earliest Phases of Star formation (EPoS): Temperature, density, and kinematic structure of the star-forming core CB 17

    CERN Document Server

    Schmalzl, M; Stutz, A M; Linz, H; Bourke, T L; Beuther, H; Henning, Th; Krause, O; Nielbock, M; Schmiedeke, A

    2014-01-01

    Context: The initial conditions for the gravitational collapse of molecular cloud cores and the subsequent birth of stars are still not well constrained. The characteristic cold temperatures (about 10 K) in such regions require observations at sub-millimetre and longer wavelengths. The Herschel Space Observatory and complementary ground-based observations presented in this paper have the unprecedented potential to reveal the structure and kinematics of a prototypical core region at the onset of stellar birth. Aims: This paper aims to determine the density, temperature, and velocity structure of the star-forming Bok globule CB 17. This isolated region is known to host (at least) two sources at different evolutionary stages: a dense core, SMM1, and a Class I protostar, IRS. Methods: We modeled the cold dust emission maps from 100 micron to 1.2 mm with both a modified blackbody technique to determine the optical depth-weighted line-of-sight temperature and column density and a ray-tracing technique to determine ...

  16. Comparative Evaluation of Shear Bond Strength of Luting Cements to Different Core Buildup Materials in Lactic Acid Buffer Solution.

    Science.gov (United States)

    Patil, Siddharam M; Kamble, Vikas B; Desai, Raviraj G; Arabbi, Kashinath C; Prakash, Ved

    2015-08-01

    The core buildup material is used to restore badly broken down tooth to provide better retention for fixed restorations. The shear bond strength of a luting agent to core buildup is one of the crucial factors in the success of the cast restoration. The aim of this invitro study was to evaluate and compare the shear bond strength of luting cements with different core buildup materials in lactic acid buffer solution. Two luting cements {Traditional Glass Ionomer luting cement (GIC) and Resin Modified Glass Ionomer luting cement (RMGIC)} and five core buildup materials {Silver Amalgam, Glass ionomer (GI), Glass Ionomer Silver Reinforced (GI Silver reinforced), Composite Resin and Resin Modified Glass Ionomer(RMGIC)} were selected for this study. Total 100 specimens were prepared with 20 specimens for each core buildup material using a stainless steel split metal die. Out of these 20 specimens, 10 specimens were bonded with each luting cement. All the bonded specimens were stored at 37(0)c in a 0.01M lactic acid buffer solution at a pH of 4 for 7days. Shear bond strength was determined using a Universal Testing Machine at a cross head speed of 0.5mm/min. The peak load at fracture was recorded and shear bond strength was calculated. The data was statistically analysed using Two-way ANOVA followed by HOLM-SIDAK method for pair wise comparison at significance level of pstrength of the luting cements (pcore materials (pstrength values than Traditional GIC luting cement for all the core buildup materials. RMGIC core material showed higher bond strength values followed by Composite resin, GI silver reinforced, GI and silver amalgam core materials for both the luting agents. Shear bond strength of RMGIC luting cement was significantly higher than traditional GIC luting cement for all core buildup materials except, for silver amalgam core buildup material. RMGIC core material showed highest shear bond strength values followed by Composite resin, GI Silver Reinforced, GI and

  17. Evaluation of the Transient Liquid Phase (TLP) Bonding Process for Ti3Al-Based Honeycomb Core Sandwich Structure

    Science.gov (United States)

    Bird, R. Keith; Hoffman, Eric K.

    1998-01-01

    The suitability of using transient liquid phase (TLP) bonding to fabricate honeycomb core sandwich panels with Ti-14Al-21Nb (wt%) titanium aluminide (T3Al) face sheets for high-temperature hypersonic vehicle applications was evaluated. Three titanium alloy honeycomb cores and one Ti3Al alloy honeycomb core were investigated. Edgewise compression (EWC) and flatwise tension (FWT) tests on honeycomb core sandwich specimens and tensile tests of the face sheet material were conducted at temperatures ranging from room temperature to 1500 F. EWC tests indicated that the honeycomb cores and diffusion bonded joints were able to stabilize the face sheets up to and beyond the face sheet compressive yield strength for all temperatures investigated. The specimens with the T3Al honeycomb core produced the highest FWT strengths at temperatures above 1000 F. Tensile tests indicated that TLP processing conditions resulted in decreases in ductility of the Ti-14Al-21Nb face sheets. Microstructural examination showed that the side of the face sheets to which the filler metals had been applied was transformed from equiaxed alpha2 grains to coarse plates of alpha2 with intergranular Beta. Fractographic examination of the tensile specimens showed that this transformed region was dominated by brittle fracture.

  18. Advice networks in teams: the role of transformational leadership and members' core self-evaluations.

    Science.gov (United States)

    Zhang, Zhen; Peterson, Suzanne J

    2011-09-01

    This article examines the team-level factors promoting advice exchange networks in teams. Drawing upon theory and research on transformational leadership, team diversity, and social networks, we hypothesized that transformational leadership positively influences advice network density in teams and that advice network density serves as a mediating mechanism linking transformational leadership to team performance. We further hypothesized a 3-way interaction in which members' mean core self-evaluation (CSE) and diversity in CSE jointly moderate the transformational leadership-advice network density relationship, such that the relationship is positive and stronger for teams with low diversity in CSE and high mean CSE. In addition, we expected that advice network centralization attenuates the positive influence of network density on team performance. Results based on multisource data from 79 business unit management teams showed support for these hypotheses. The results highlight the pivotal role played by transformational leadership and team members' CSEs in enhancing team social networks and, ultimately, team effectiveness. PsycINFO Database Record (c) 2011 APA, all rights reserved

  19. Core self-evaluations and training effectiveness: prediction through motivational intervening mechanisms.

    Science.gov (United States)

    Stanhope, Daniel S; Pond, Samuel B; Surface, Eric A

    2013-09-01

    Understanding the processes through which trainee characteristics influence learning is important for identifying mechanisms that drive training effectiveness. We examine the direct and indirect paths through which core self-evaluations (CSE) impact learning. We also include general cognitive ability (GCA) to explore whether CSE's paths to effectiveness differ from those of a well-documented predictor of learning. We proposed a model in which CSE contributes to training effectiveness through its influence on motivational intervening mechanisms, and we tested this model empirically with military personnel (N = 638) who participated in job-required training. The data supported a partially mediated model. Irrespective of inclusion of GCA as a control variable, motivation and effort allocation (MEA) process variables (i.e., training motivation, midtraining self-efficacy, and midtraining goal setting) mediated (or partially mediated) the relationship between CSE and training outcomes that included affective (e.g., intentions to transfer), cognitive (e.g., declarative knowledge), and skill-based (e.g., proficiency) learning. Conversely, GCA had neither direct nor indirect effects on affective learning but did demonstrate direct effects on cognitive and skill-based learning. Results support the utility of including CSE in training research and practice, suggest that MEA serves as an explanatory mechanism for CSE's relation to learning outcomes, and demonstrate that CSE and GCA differentially influence training effectiveness and do so through different explanatory mechanisms.

  20. Parental Influences on Greek Adolescents' Career Decision-Making Difficulties: The Mediating Role of Core Self-Evaluations

    Science.gov (United States)

    Koumoundourou, Georgia; Tsaousis, Ioannis; Kounenou, Kalliope

    2011-01-01

    The purpose of the study was to explore the influence of family characteristics (family function and parental authority styles) and core self-evaluations (CSE), in adolescents' career formation. Drawing on the relational framework of Cutrona and Russell, the study examined the mediating role of CSE on the relationship between family and parental…

  1. Negative Attitudes toward Older Workers and Hiring Decisions: Testing the Moderating Role of Decision Makers’ Core Self-Evaluations

    Science.gov (United States)

    Fasbender, Ulrike; Wang, Mo

    2017-01-01

    Organizational hiring practices have been charged for unfair treatment on the grounds of age. Drawing on theories of planned behavior and core self-evaluations, this research investigated the impact of negative attitudes toward older workers on hiring decisions and examined the moderating role of decision-makers’ core self-evaluations. We tested our hypotheses based on a structured online questionnaire and a vignette study using a sample of 102 participants working in human resource management across different industries. As predicted, negative attitudes toward older workers were positively related to avoidance of hiring older people, which in turn was negatively related to the likelihood to select the oldest candidate. Because hiring decisions are not only about the hiring subject but also about the decision-maker, we tested the moderating role of decision-makers’ core self-evaluations. Results showed that core self-evaluations buffered the relationship between negative attitudes toward older workers and avoidance of hiring older people. Theoretical implications of the findings with regard to hiring decisions about older people and practical recommendations to improve diversity management strategies and age-balanced hiring practices in organizations are discussed. PMID:28127291

  2. Middle School Mathematics Teachers' Perceptions of the Common Core State Standards for Mathematics and Related Assessment and Teacher Evaluation Systems

    Science.gov (United States)

    McDuffie, Amy Roth; Drake, Corey; Choppin, Jeffrey; Davis, Jon D.; Magaña, Margarita V.; Carson, Cynthia

    2017-01-01

    In this study, U.S. middle school teachers' perceptions of Common Core State Standards for Mathematics (CCSSM), CCSSM-related assessments, teacher evaluation processes, and resources for implementing CCSSM were investigated. Using a mixed methods design, a national sample of 366 teachers was surveyed, and 24 teachers were interviewed. Findings…

  3. Parental Influences on Greek Adolescents' Career Decision-Making Difficulties: The Mediating Role of Core Self-Evaluations

    Science.gov (United States)

    Koumoundourou, Georgia; Tsaousis, Ioannis; Kounenou, Kalliope

    2011-01-01

    The purpose of the study was to explore the influence of family characteristics (family function and parental authority styles) and core self-evaluations (CSE), in adolescents' career formation. Drawing on the relational framework of Cutrona and Russell, the study examined the mediating role of CSE on the relationship between family and parental…

  4. Investigating the Influences of Core Self-Evaluations, Job Autonomy, and Intrinsic Motivation on In-Role Job Performance

    Science.gov (United States)

    Joo, Baek-Kyoo; Jeung, Chang-Wook; Yoon, Hea Jun

    2010-01-01

    This study investigates the effects of core self-evaluations, job autonomy, and intrinsic motivation on employees' perceptions of their in-role job performance, based on a cross-sectional survey of 283 employees in a Fortune Global 100 company in Korea. The results suggest that employees perceived higher in-role job performance when they had…

  5. Turnover intentions of employees with informal eldercare responsibilities : The role of core self-evaluations and supervisor support

    NARCIS (Netherlands)

    Greaves, Claire E.; Parker, Stacey L.; Zacher, Hannes; Jimmieson, Nerina L.

    2015-01-01

    As longevity increases, so does the need for care of older relatives by working family members. This research examined the interactive effect of core self-evaluations and supervisor support on turnover intentions in two samples of employees with informal caregiving responsibilities. Data were obtain

  6. Turnover Intentions of Employees With Informal Eldercare Responsibilities: The Role of Core Self-Evaluations and Supervisor Support.

    Science.gov (United States)

    Greaves, Claire E; Parker, Stacey L; Zacher, Hannes; Jimmieson, Nerina L

    2015-12-01

    As longevity increases, so does the need for care of older relatives by working family members. This research examined the interactive effect of core self-evaluations and supervisor support on turnover intentions in two samples of employees with informal caregiving responsibilities. Data were obtained from 57 employees from Australia (Study 1) and 66 employees from the United States and India (Study 2). Results of Study 1 revealed a resource compensation effect, that is, an inverse relationship between core self-evaluations and turnover intentions when supervisor care support was low. Results of Study 2 extended these findings by demonstrating resource boosting effects. Specifically, there was an inverse relationship between core self-evaluations and subsequent turnover intentions for those with high supervisor work and care support. In addition, employees' satisfaction and emotional exhaustion from their work mediated the inverse relationship between core self-evaluations and subsequent turnover intentions when supervisor work support and care support were high. Overall, these findings highlight the importance of employee- and supervisor-focused intervention strategies in organizations to support informal caregivers.

  7. Evaluating the MEDLINE Core Clinical Journals filter: data-driven evidence assessing clinical utility.

    Science.gov (United States)

    Klein-Fedyshin, Michele; Ketchum, Andrea M; Arnold, Robert M; Fedyshin, Peter J

    2014-12-01

    MEDLINE offers the Core Clinical Journals filter to limit to clinically useful journals. To determine its effectiveness for searching and patient-centric decision making, this study compared literature used for Morning Report in Internal Medicine with journals in the filter. An EndNote library with references answering 327 patient-related questions during Morning Report from 2007 to 2012 was exported to a file listing variables including designated Core Clinical Journal, Impact Factor, date used and medical subject. Bradford's law of scattering was applied ranking the journals and reflecting their clinical utility. Recall (sensitivity) and precision of the Core Morning Report journals and non-Core set was calculated. This study applied bibliometrics to compare the 628 articles used against these criteria to determine journals impacting decision making. Analysis shows 30% of clinically used articles are from the Core Clinical Journals filter and 16% of the journals represented are Core titles. When Bradford-ranked, 55% of the top 20 journals are Core. Articles Journals filter indicates less relevance for hospital-based care. The divergence from high-impact medicine titles suggests clinically valuable journals differ from academically important titles. With few subjects demonstrating high recall or precision, the MEDLINE Core Clinical Journals filter may require a review and update to better align with current clinical needs. © 2014 John Wiley & Sons, Ltd.

  8. CT-guided core needle biopsy of pleural lesions: Evaluating diagnostic yield and associated complications

    Energy Technology Data Exchange (ETDEWEB)

    Niu, Xiang Ke [Dept. of Radiology, Affiliated Hospital of Chengdu University, Chengdu (China); Bhetuwal, Anup; Yang, Han Feng [Dept. of Radiology, Sichuan Key Laboratory of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, Nanchong (China)

    2015-02-15

    The purpose of this study was to retrospectively evaluate the diagnostic accuracy and complications of CT-guided core needle biopsy (CT-guided CNB) of pleural lesion and the possible effects of influencing factors. From September 2007 to June 2013, 88 consecutive patients (60 men and 28 women; mean [+/- standard deviation] age, 51.1 +/- 14.4 years; range, 19-78 years) underwent CT-guided CNB, which was performed by two experienced chest radiologists in our medical center. Out of 88 cases, 56 (63%) were diagnosed as malignant, 28 (31%) as benign and 4 (5%) as indeterminate for CNB of pleural lesions. The final diagnosis was confirmed by either histopathological diagnosis or clinical follow-up. The diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and complication rates were statistically evaluated. Influencing factors (patient age, sex, lesion size, pleural-puncture angle, patient position, pleural effusion, and number of pleural punctures) were assessed for their effect on accuracy of CT-guided CNB using univariate and subsequent multivariate analysis. Diagnostic accuracy, sensitivity, specificity, PPV, and NPV were 89.2%, 86.1%, 100%, 100%, and 67.8%, respectively. The influencing factors had no significant effect in altering diagnostic accuracy. As far as complications were concerned, occurrence of pneumothorax was observed in 14 (16%) out of 88 patients. Multivariate analysis revealed lesion size/pleural thickening as a significant risk factor (odds ratio [OR]: 8.744, p = 0.005) for occurrence of pneumothorax. Moreover, presence of pleural effusion was noted as a significant protective factor (OR: 0.171, p = 0.037) for pneumothorax. CT-guided CNB of pleural lesion is a safe procedure with high diagnostic yield and low risk of significant complications.

  9. Evaluation of shear bond strength between zirconia core and ceramic veneers fabricated by pressing and layering techniques: In vitro study.

    Science.gov (United States)

    Subash, M; Vijitha, D; Deb, Saikat; Satish, A; Mahendirakumar, N

    2015-08-01

    Although ceramic veneered on to zirconia core have been in use for quite some time, information regarding the comparative evaluation of the Shear bond strength of Pressable & Layered ceramic veneered on to zirconia core is limited. To evaluate the shear bond strength of zirconia core and ceramic veneer fabricated by two different techniques, Layering (Noritake CZR) and Pressing (Noritake, CZR Press). 20 samples of zirconia blocks were fabricated and the samples were divided into group A & B. Group A - Ceramic Veneered over zirconia core by pressing using Noritake CZR Press. Group B - Ceramic Veneered over zirconia core by layering using Noritake CZR. The veneered specimens were mounted on to the center of a PVC tube using self-cure acrylic resin leaving 3 mm of the veneered surface exposed as cantilever. Using a Universal testing machine the blocks were loaded up to failure. The results were tabulated by using independent samples t-test. The mean shear bond strength for Pressed specimens was 12.458 ± 1.63(S.D) MPa and for layered specimens was 8.458 ± 0.845(S.D) MPa. Pressed specimens performed significantly better than the layered specimen with a P value 0.001. Clinicians and dental laboratory technicians should consider the use of pressed ceramics as an alternative to traditional layering procedures to reduce the chances of chipping or de-lamination of ceramics.

  10. Biomechanical evaluation of bending strength of spinal pedicle screws, including cylindrical, conical, dual core and double dual core designs using numerical simulations and mechanical tests.

    Science.gov (United States)

    Amaritsakul, Yongyut; Chao, Ching-Kong; Lin, Jinn

    2014-09-01

    Pedicle screws are used for treating several types of spinal injuries. Although several commercial versions are presently available, they are mostly either fully cylindrical or fully conical. In this study, the bending strengths of seven types of commercial pedicle screws and a newly designed double dual core screw were evaluated by finite element analyses and biomechanical tests. All the screws had an outer diameter of 7 mm, and the biomechanical test consisted of a cantilever bending test in which a vertical point load was applied using a level arm of 45 mm. The boundary and loading conditions of the biomechanical tests were applied to the model used for the finite element analyses. The results showed that only the conical screws with fixed outer diameter and the new double dual core screw could withstand 1,000,000 cycles of a 50-500 N cyclic load. The new screw, however, exhibited lower stiffness than the conical screw, indicating that it could afford patients more flexible movements. Moreover, the new screw produced a level of stability comparable to that of the conical screw, and it was also significantly stronger than the other screws. The finite element analysis further revealed that the point of maximum tensile stress in the screw model was comparable to the point at which fracture occurred during the fatigue test. Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.

  11. An Evaluation of a Language for Paper-based Form Sketching

    DEFF Research Database (Denmark)

    Farruglia, Phillip; Borg, Johnathan; Camilleri, K.P.

    2006-01-01

    between paper-based form sketching and CAGM systems. Evaluation results revealed that whilst PSL is easy-to-learn, yet it requires improvements. Such a sketching language contributes a step towards simulating early form design solutions by the combined use of paper-based sketches and 3D models....... form idea. The research disclosed in this paper is aimed at combining the benefits of paper-based freehand sketches with those of three-dimensional (3D) models. More specifically, this paper reports the on-going development of a prescribed sketching language (PSL) required to create a seamless link...

  12. Polar Order and Symmetry Breaking at the Boundary between Bent-Core and Rodlike Molecular Forms: When 4-Cyanoresorcinol Meets the Carbosilane End Group.

    Science.gov (United States)

    Westphal, Eduard; Gallardo, Hugo; Caramori, Giovanni Finoto; Sebastián, Nerea; Tamba, Maria-Gabriela; Eremin, Alexey; Kawauchi, Susumu; Prehm, Marko; Tschierske, Carsten

    2016-06-01

    Two isomeric achiral bent-core liquid crystals involving a 4-cyanoresorcinol core and containing a carbosilane unit as nanosegregating segment were synthesized and were shown to form ferroelectric liquid-crystalline phases. Inversion of the direction of one of the COO groups in these molecules leads to a distinct distribution of the electrostatic potential along the surface of the molecule and to a strong change of the molecular dipole moments. Thus, a distinct degree of segregation of the carbosilane units and consequent modification of the phase structure and coherence length of polar order result. For the compound with larger dipole moment (CN1) segregation of the carbosilane units is suppressed, and this compound forms paraelectric SmA and SmC phases; polar order is only achieved after transition to a new LC phase, namely, the ferroelectric leaning phase (SmCLs PS ) with the unique feature that tilt direction and polar direction coincide. The isomeric compound CN2 with a smaller dipole moment forms separate layers of the carbosilane groups and shows a randomized polar SmA phase (SmAPAR ) and ferroelectric polydomain SmCs PS phases with orthogonal combination of tilt and polar direction and much higher polarizations. Thus, surprisingly, the compound with the smaller molecular dipole moment shows increased polar order in the LC phases. Besides ferroelectricity, mirror-symmetry breaking with formation of a conglomerate of macroscopic chiral domains was observed in one of the SmC phases of CN1. These investigations contribute to the general understanding of the development of polar order and chirality in soft matter.

  13. SpaceCubeX: A Framework for Evaluating Hybrid Multi-Core CPU FPGA DSP Architectures

    Science.gov (United States)

    Schmidt, Andrew G.; Weisz, Gabriel; French, Matthew; Flatley, Thomas; Villalpando, Carlos Y.

    2017-01-01

    The SpaceCubeX project is motivated by the need for high performance, modular, and scalable on-board processing to help scientists answer critical 21st century questions about global climate change, air quality, ocean health, and ecosystem dynamics, while adding new capabilities such as low-latency data products for extreme event warnings. These goals translate into on-board processing throughput requirements that are on the order of 100-1,000 more than those of previous Earth Science missions for standard processing, compression, storage, and downlink operations. To study possible future architectures to achieve these performance requirements, the SpaceCubeX project provides an evolvable testbed and framework that enables a focused design space exploration of candidate hybrid CPU/FPGA/DSP processing architectures. The framework includes ArchGen, an architecture generator tool populated with candidate architecture components, performance models, and IP cores, that allows an end user to specify the type, number, and connectivity of a hybrid architecture. The framework requires minimal extensions to integrate new processors, such as the anticipated High Performance Spaceflight Computer (HPSC), reducing time to initiate benchmarking by months. To evaluate the framework, we leverage a wide suite of high performance embedded computing benchmarks and Earth science scenarios to ensure robust architecture characterization. We report on our projects Year 1 efforts and demonstrate the capabilities across four simulation testbed models, a baseline SpaceCube 2.0 system, a dual ARM A9 processor system, a hybrid quad ARM A53 and FPGA system, and a hybrid quad ARM A53 and DSP system.

  14. Core self-evaluations and work engagement: Testing a perception, action, and development path.

    Science.gov (United States)

    Tims, Maria; Akkermans, Jos

    2017-01-01

    Core self-evaluations (CSE) have predictive value for important work outcomes such as job satisfaction and job performance. However, little is known about the mechanisms that may explain these relationships. The purpose of the present study is to contribute to CSE theory by proposing and subsequently providing a first test of theoretically relevant mediating paths through which CSE may be related to work engagement. Based on approach/avoidance motivation and Job Demands-Resources theory, we examined a perception (via job characteristics), action (via job crafting), and development path (via career competencies). Two independent samples were obtained from employees working in Germany and The Netherlands (N = 303 and N = 404, respectively). When taking all mediators into account, results showed that the perception path represented by autonomy and social support played a minor role in the relationship between CSE and work engagement. Specifically, autonomy did not function as a mediator in both samples while social support played a marginally significant role in the CSE-work engagement relationship in sample 1 and received full support in sample 2. The action path exemplified by job crafting mediated the relationship between CSE and work engagement in both samples. Finally, the development path operationalized with career competencies mediated the relationship between CSE and work engagement in sample 1. The study presents evidence for an action and development path over and above the often tested perception path to explain how CSE is related to work engagement. This is one of the first studies to propose and show that CSE not only influences perceptions but also triggers employee actions and developmental strategies that relate to work engagement.

  15. Evaluation of isotopic composition of fast reactor core in closed nuclear fuel cycle

    Science.gov (United States)

    Tikhomirov, Georgy; Ternovykh, Mikhail; Saldikov, Ivan; Fomichenko, Peter; Gerasimov, Alexander

    2017-09-01

    The strategy of the development of nuclear power in Russia provides for use of fast power reactors in closed nuclear fuel cycle. The PRORYV (i.e. «Breakthrough» in Russian) project is currently under development. Within the framework of this project, fast reactors BN-1200 and BREST-OD-300 should be built to, inter alia, demonstrate possibility of the closed nuclear fuel cycle technologies with plutonium as a main source of energy. Russia has a large inventory of plutonium which was accumulated in the result of reprocessing of spent fuel of thermal power reactors and conversion of nuclear weapons. This kind of plutonium will be used for development of initial fuel assemblies for fast reactors. The closed nuclear fuel cycle concept of the PRORYV assumes self-supplied mode of operation with fuel regeneration by neutron capture reaction in non-enriched uranium, which is used as a raw material. Operating modes of reactors and its characteristics should be chosen so as to provide the self-sufficient mode by using of fissile isotopes while refueling by depleted uranium and to support this state during the entire period of reactor operation. Thus, the actual issue is modeling fuel handling processes. To solve these problems, the code REPRORYV (Recycle for PRORYV) has been developed. It simulates nuclide streams in non-reactor stages of the closed fuel cycle. At the same time various verified codes can be used to evaluate in-core characteristics of a reactor. By using this approach various options for nuclide streams and assess the impact of different plutonium content in the fuel, fuel processing conditions, losses during fuel processing, as well as the impact of initial uncertainties on neutron-physical characteristics of reactor are considered in this study.

  16. Clogging evaluation of porous asphalt concrete cores in conjunction with medical x-ray computed tomography

    Science.gov (United States)

    Su, Yu-Min; Hsu, Chen-Yu; Lin, Jyh-Dong

    2014-03-01

    This study was to assess the porosity of Porous Asphalt Concrete (PAC) in conjunction with a medical X-ray computed tomography (CT) facility. The PAC was designed as the surface course to achieve the target porosity 18%. There were graded aggregates, soils blended with 50% of coarse sand, and crushed gravel wrapped with geotextile compacted and served as the base, subbase, and infiltration layers underneath the PAC. The test site constructed in 2004 is located in Northern of Taiwan in which the daily traffic has been light and limited. The porosity of the test track was investigated. The permeability coefficient of PAC was found severely degraded from 2.2×10-1 to 1.2×10-3 -cm/sec, after nine-year service, while the permeability below the surface course remained intact. Several field PAC cores were drilled and brought to evaluate the distribution of air voids by a medical X-ray CT nondestructively. The helical mode was set to administrate the X-ray CT scan and two cross-sectional virtual slices were exported in seconds for analyzing air voids distribution. It shows that the clogging of voids occurred merely 20mm below the surface and the porosity can reduce as much about 3%. It was also found that the roller compaction can decrease the porosity by 4%. The permeability reduction in this test site can attribute to the voids of PAC that were compacted by roller during the construction and filled by the dusts on the surface during the service.

  17. The permafrost carbon inventory on the Tibetan Plateau: a new evaluation using deep sediment cores.

    Science.gov (United States)

    Ding, Jinzhi; Li, Fei; Yang, Guibiao; Chen, Leiyi; Zhang, Beibei; Liu, Li; Fang, Kai; Qin, Shuqi; Chen, Yongliang; Peng, Yunfeng; Ji, Chengjun; He, Honglin; Smith, Pete; Yang, Yuanhe

    2016-08-01

    The permafrost organic carbon (OC) stock is of global significance because of its large pool size and the potential positive feedback to climate warming. However, due to the lack of systematic field observations and appropriate upscaling methodologies, substantial uncertainties exist in the permafrost OC budget, which limits our understanding of the fate of frozen carbon in a warming world. In particular, the lack of comprehensive estimates of OC stocks across alpine permafrost means that current knowledge on this issue remains incomplete. Here, we evaluated the pool size and spatial variations of permafrost OC stock to 3 m depth on the Tibetan Plateau by combining systematic measurements from a substantial number of pedons (i.e. 342 three-metre-deep cores and 177 50-cm-deep pits) with a machine learning technique (i.e. support vector machine, SVM). We also quantified uncertainties in permafrost carbon budget by conducting Monte Carlo simulations. Our results revealed that the combination of systematic measurements with the SVM model allowed spatially explicit estimates to be made. The OC density (OC amount per unit area, OCD) exhibited a decreasing trend from the south-eastern to the north-western plateau, with the exception that OCD in the swamp meadow was substantially higher than that in surrounding regions. Our results also demonstrated that Tibetan permafrost stored a large amount of OC in the top 3 m, with the median OC pool size being 15.31 Pg C (interquartile range: 13.03-17.77 Pg C). 44% of OC occurred in deep layers (i.e. 100-300 cm), close to the proportion observed across the northern circumpolar permafrost region. The large carbon pool size together with significant permafrost thawing suggests a risk of carbon emissions and positive climate feedback across the Tibetan alpine permafrost region.

  18. Public-Private Partnership as the Core Form of the Implementation of Russia’s Transport and Transit Potential

    Directory of Open Access Journals (Sweden)

    Valery Anatolyevich Tsvetkov

    2017-03-01

    Full Text Available The article discusses the theory and practice of the implementation and development of transport and transit potential (TTP of Russia. This could be an effective way to replace the natural resource rent as the main source of income for the state and economic actors. For the modernization of national economic system the key importance are innovative technologies in the development of transport and transit potential through the organization of the production of goods and services with the highest added value in Russia. We proposed and substantiated the hypothesis about the necessity of creation of a Federal company responsible for the financing and implementation of Russia’s transport and transit potential development projects on the principles of public-private partnership (PPP. The authors have revealed the economic, institutional and organizational prerequisites for the establishment of such a public-private partnership company. We have provided the opinions of scientists and experts showing the urgent need to create in one form or another a single operator to transport goods on the territory of Russia and the Eurasian economic Union. To prove the hypothesis, we presented a description and analysis of the factors affecting the value of transit freight transport on Euro-Asian routes. We paid the special attention to identify the reasons of the increasing competitive advantage of Maritime transport in the world’s goods movement system. The authors based the main conclusion that, first of all, the created publicprivate partnership company should be large due to tough competition of developing transit freight by land routes with the global Maritime container services. Secondly, it needs a significant state participation since the management of the world’s cargo flows requires the effort of foreign policy and geo-economic nature. We emphasized that this business entity would become an active proponent and lobbyist of the most effective

  19. 78 FR 40760 - 60-Day Notice of Proposed Information Collection: Training Evaluation Form

    Science.gov (United States)

    2013-07-08

    ... URBAN DEVELOPMENT 60-Day Notice of Proposed Information Collection: Training Evaluation Form AGENCY... seeking approval from the Office of Management and Budget (OMB) for the information collection described... parties on the proposed collection of information. The purpose of this notice is to allow for 60 days...

  20. Syndrome dimensions of the Child Behavior Checklist and the Teacher Report Form : a critical empirical evaluation

    NARCIS (Netherlands)

    Hartman, CA; Hox, J; Auerbach, J; Erol, N; Fonseca, AC; Mellenbergh, GJ; Novik, TS; Oosterlaan, J; Roussos, AC; Shalev, RS; Zilber, N; Sergeant, JA

    1999-01-01

    The construct representation of the cross-informant model of the Child Behavior Checklist (CBCL) and the Teacher Report Form (TRF) was evaluated using confirmatory factor analysis. Samples were collected in seven different countries. The results are based on 13,226 parent ratings and 8893 teacher

  1. Syndrome dimensions of the Child Behavior Checklist and the Teacher Report Form : a critical empirical evaluation

    NARCIS (Netherlands)

    Hartman, CA; Hox, J; Auerbach, J; Erol, N; Fonseca, AC; Mellenbergh, GJ; Novik, TS; Oosterlaan, J; Roussos, AC; Shalev, RS; Zilber, N; Sergeant, JA

    1999-01-01

    The construct representation of the cross-informant model of the Child Behavior Checklist (CBCL) and the Teacher Report Form (TRF) was evaluated using confirmatory factor analysis. Samples were collected in seven different countries. The results are based on 13,226 parent ratings and 8893 teacher ra

  2. An Improved "Form of Our Own": A 21st Century Approach to School Librarian Evaluation

    Science.gov (United States)

    Owen, Patricia L.

    2011-01-01

    School librarians need evaluation forms that fit their unique roles and responsibilities and acknowledge both the similarities and differences between classroom teachers and school librarians. The incorporation of American Association of School Librarians' (AASL's) "Empowering Learners: Guidelines for School Library Programs"--a resource that sets…

  3. Concept and methodology for evaluating core damage frequency considering failure correlation at multi units and sites and its application

    Energy Technology Data Exchange (ETDEWEB)

    Ebisawa, K.; Teragaki, T.; Nomura, S. [Former Incorporated Administrative Agency, Japan Nuclear Safety Organization (Japan); Abe, H., E-mail: Hiroshi_abe@nsr.go.jp [Former Incorporated Administrative Agency, Japan Nuclear Safety Organization (Japan); Shigemori, M.; Shimomoto, M. [Mizuho Information & Research Institute, 2-3, Kanda-Nishikicho, Chiyoda-ku, Tokyo (Japan)

    2015-07-15

    Highlights: • We develop a method to evaluate CDF considering failure correlation at multi units. • We develop a procedure to evaluate correlation coefficient between multi components. • We evaluate CDF at two different BWR units using correlation coefficients. • We confirm the validity of method and correlation coefficient through the evaluation. - Abstract: The Tohoku earthquake (Mw9.0) occurred on March 11, 2011 and caused a large tsunami. The Fukushima Daiichi Nuclear Power Plant with six units were overwhelmed by the tsunami and core damage occurred. Authors proposed the concept and method for evaluating core damage frequency (CDF) considering failure correlation at the multi units and sites. Based on the above method, one of authors developed the procedure for evaluating the failure correlation coefficient and response correlation coefficient between the multi components under the strong seismic motion. These method and failure correlation coefficients were applied to two different BWR units and their CDF was evaluated by seismic probabilistic risk assessment technology. Through this quantitative evaluation, the validity of the method and failure correlation coefficient was confirmed.

  4. Quality evaluation of the Finasteride polymorphic forms I and II in capsules.

    Science.gov (United States)

    da Silva, Lucélia Magalhães; Montanari, Cristina Martiniano; Santos, Olimpia Maria Martins; Cazedey, Edith Cristina Laignier; Ângelo, Marilene Lopes; de Araújo, Magali Benjamin

    2015-02-01

    Finasteride (FNS) is a specific competitive inhibitor of steroid type-II 5α-reductase and is widely used for the treatment of benign prostatic hyperplasia, prostate cancer, and androgenetic alopecia. FNS has two polymorphic forms identified as Form I and Form II. It is known that polymorphism can cause significant differences in the physicochemical properties of a compound such as melting point, density, morphology, solubility, and color. Thus, proper qualitative and quantitative monitoring of the solid-state forms is crucial to ensure high-quality products. There are no published papers studying the influence of the FNS polymorphs on the physicochemical quality of capsules. Furthermore, the available analytical methods are time-consuming, expensive, use buffer or do not demonstrate stability-indicating capacity. The aim of this work was to validate a rapid high-performance liquid chromatography (HPLC) method to evaluate FNS in capsules and to study the physicochemical properties of polymorphic forms, evaluating their possible influence in the dissolution profile and stability of FNS in capsules. Capsules containing Forms I and II of FNS were prepared and subjected to quality control studies, dissolution profiles and a stability study at 50°C. A significant effect of polymorphism on the FNS solubility and dissolution properties was observed. These results suggest that changes in the effects of FNS can occur if a suitable control study is not performed on the raw material used to produce the capsules. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Comparative evaluation of effects of different surface treatment methods on bond strength between fiber post and composite core.

    Science.gov (United States)

    Mosharraf, Ramin; Baghaei Yazdi, Najmeh

    2012-05-01

    Debonding of a composite resin core of the fiber post often occurs at the interface between these two materials. The aim of this study was to evaluate the effects of different surface treatment methods on bond strength between fiber posts and composite core. Sixty-four fiber posts were picked in two groups (Hetco and Exacto). Each group was further divided into four subgroups using different surface treatments: 1) silanization; 2) sandblasting; 3) Treatment with 24% H(2)O(2), and 4) no treatment (control group). A cylindrical plexiglass matrix was placed around the post and filled with the core resin composite. Specimens were stored in 5000 thermal cycles between 5℃ and 55℃. Tensile bond strength (TBS) test and evaluation using stereomicroscope were performed on the specimen and the data were analyzed using two-way ANOVA, Post Hoc Scheffe tests and Fisher's Exact Test (α=.05). There was a significant difference between the effect of different surface treatments on TBS (Pstrength of fiber posts to composite resin core, but there were not any significant differences between these groups and control group. There was not any significant difference between two brands of fiber posts that had been used in this study. Although silanization and sandblasting can improve the TBS, there was not any significant differences between surface treatments used.

  6. Evaluation of Physical Characteristics of PWR Cores with Accident Tolerant Fuels

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Dae Hee; Hong, Ser Gi [Kyung Hee University, Yongin (Korea, Republic of); In, Wang Kee [KAERI, Daejeon (Korea, Republic of)

    2015-10-15

    The accident tolerant fuels (ATF) considered in this work includes metallic microcell UO{sub 2} pellets and outer Cr-based alloy coating on cladding, which is being developed in KAERI (Korea Atomic Energy Research Institute). Chromium metals have been used in many fields because of its hardness and corrosion-resistance. The use of the chromium metal in nuclear fuel rod can enhance the conductivity of pellets and corrosion-resistance of cladding. The objective of this work is to study the neutronic performances and characteristics of the commercial PWR core loaded the ATF-bearing assemblies. In this work, we studied the PWR cores which are loaded with ATF assemblies to improve the safety of reactor core. The ATF rod consists of the metallic microcell UO2 pellet which includes chromium of 3.34 wt% and the outer 0.05mm thick coating of Cr-based alloy with atomic number ratio of 85:15. We performed the cycle-by-cycle reload core analysis from the cycle 8 at which the ATF fuel assemblies start to be loaded into the core. The target nuclear power plant is the Hanbit-3 nuclear power plant. From the analysis, it was found that 1) the uranium enrichment is required to be increased up to 5.20/4.70 wt% in order to satisfy a required cycle length of 480 EFPDs, 2) the cycle length for the core using ATF fuel assemblies with the same uranium enrichments as those in the reference UO{sub 2} fueled core is decreased from 480 EFPDs to 430 EFPDs.

  7. Evaluation of post-surface conditioning to improve interfacial adhesion in post-core restorations

    Directory of Open Access Journals (Sweden)

    Mylswamy Sumitha

    2011-01-01

    Full Text Available Aim : To examine the influence of different post-surface treatments on the interfacial strength between epoxy resin-based fiber posts and methacrylate-based resin composites that are employed as core build-up materials. Materials and Methods : Forty clear posts were divided into four groups of 10 each. The different surface treatments used were etching with alkaline potassium permanganate, 10% hydrogen peroxide, 37% phosphoric acid, and silanization alone. After etching and thorough rinsing, a single layer of silane was applied to the post surface. Then the post was placed in a rectangular plastic matrix and core bulid-up was done using Multi Core, a dual cured composite resin. A slab of uniform thickness, with the post in the center and the core build-up composite on either side was created. The specimens were cut so as to obtain microtensile sticks that were loaded in tension at a cross-head speed of 1 mm/min until failure. The statistical analysis was performed using two-way ANOVA and the paired T test for post-hoc comparisons. Results : The results achieved with potassium permanganate had a significant influence on microtensile interfacial bond strength values with the tested material. Conclusion : Surface chemical treatments of the resin phase of fiber posts enhance the silanization efficiency of the quartz fiber phase, so that the adhesion in the post/core unit may be considered as a net sum of chemical and micromechanical retention.

  8. I won't let you down... or will I? Core self-evaluations, other-orientation, anticipated guilt and gratitude, and job performance.

    Science.gov (United States)

    Grant, Adam M; Wrzesniewski, Amy

    2010-01-01

    Although core self-evaluations have been linked to higher job performance, research has shown variability in the strength of this relationship. We propose that high core self-evaluations are more likely to increase job performance for other-oriented employees, who tend to anticipate feelings of guilt and gratitude. We tested these hypotheses across 3 field studies using different operationalizations of both performance and other-orientation (prosocial motivation, agreeableness, and duty). In Study 1, prosocial motivation strengthened the association between core self-evaluations and the performance of professional university fundraisers. In Study 2, agreeableness strengthened the association between core self-evaluations and supervisor ratings of initiative among public service employees. In Study 3, duty strengthened the association between core self-evaluations and the objective productivity of call center employees, and this moderating relationship was mediated by feelings of anticipated guilt and gratitude. We discuss implications for theory and research on personality and job performance.

  9. 48 CFR 1553.209-70 - EPA Form 1900-26, Contracting Officer's Evaluation of Contractor Performance.

    Science.gov (United States)

    2010-10-01

    ..., Contracting Officer's Evaluation of Contractor Performance. 1553.209-70 Section 1553.209-70 Federal... 1553.209-70 EPA Form 1900-26, Contracting Officer's Evaluation of Contractor Performance. As prescribed... evaluation of Contractor performance....

  10. Evaluation of in-vitro antibiotic susceptibility of different morphological forms of Borrelia burgdorferi

    Directory of Open Access Journals (Sweden)

    Sapi E

    2011-05-01

    Full Text Available Eva Sapi1, Navroop Kaur1, Samuel Anyanwu1, David F Luecke1, Akshita Datar1, Seema Patel1, Michael Rossi1, Raphael B Stricker21Lyme Disease Research Group, Department of Biology and Environmental Sciences, University of New Haven, New Haven, CT, USA; 2International Lyme and Associated Diseases Society, Bethesda, MD, USABackground: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due to formation of different morphological forms of B. burgdorferi, namely round bodies (cysts and biofilm-like colonies. Better understanding of the effect of antibiotics on all morphological forms of B. burgdorferi is therefore crucial to provide effective therapy for Lyme disease.Methods: Three morphological forms of B. burgdorferi (spirochetes, round bodies, and biofilm-like colonies were generated using novel culture methods. Minimum inhibitory concentration and minimum bactericidal concentration of five antimicrobial agents (doxycycline, amoxicillin, tigecycline, metronidazole, and tinidazole against spirochetal forms of B. burgdorferi were evaluated using the standard published microdilution technique. The susceptibility of spirochetal and round body forms to the antibiotics was then tested using fluorescent microscopy (BacLight™ viability staining and dark field microscopy (direct cell counting, and these results were compared with the microdilution technique. Qualitative and quantitative effects of the antibiotics against biofilm-like colonies were assessed using fluorescent microscopy and dark field microscopy, respectively.Results: Doxycycline reduced spirochetal structures ~90% but increased the number of round body forms about twofold. Amoxicillin reduced spirochetal forms by ~85%–90% and round body

  11. High-Entropy Alloys: A Current Evaluation of Founding Ideas and Core Effects and Exploring "Nonlinear Alloys"

    Science.gov (United States)

    Miracle, Daniel B.

    2017-08-01

    The burgeoning field of high-entropy alloys (HEAs) is underpinned by two foundational concepts, and early research has been motivated by several hypotheses known as "core effects." The field is now entering its teenage years, and sufficient data have been collected to evaluate these hypotheses and to take a fresh look at the foundational concepts. Although recent assessments have concluded that two of the four HEA hypotheses are not supported by available data, new studies are already coming online to extend these analyses, and new interpretations are inspiring new directions for research within the field. This article gives an up-to-date evaluation of the HEA "core effects" and proposes "nonlinear alloys" as a new strategy to embrace the founding concept of compositional and microstructural vastness.

  12. Aging life evaluation of a new carbon fiber composite core wire

    Science.gov (United States)

    Cao, Jiangming; Wang, Zhihua; Zhang, Yongbo; Fu, Huimin

    2017-01-01

    The carbon fiber composite core wire is the key component for new overhead transmission lines in the power industry. As the primary load-bearing member, the composite mandrel will produce long-term creep because of the tensile during operation. Therefore, designers need to understand the long-term deformation behaviour of the composite mandrel to assess its durability. To this end, an accelerated creep test on the composite core rod under different temperatures and stresses has been conducted in the current study. According to the time- temperature- stress superposition principle, the shift factors are calculated, and the creep under normal working condition is predicted. Results show that the carbon fiber composite core wire can satisfy the design requirements under normal working condition.

  13. Evaluation of Retention of two Different Cast Post-Core Systems and Fracture Resistance of the Restored Teeth

    Science.gov (United States)

    Khaledi, Amir Ali Reza; Sheykhian, Shekufe; Khodaei, Arash

    2015-01-01

    Statement of the Problem The survival of pulpless teeth restored with different post and core systems is still a controversial issue. Purpose This study compared the retention of two different post and core systems and also the fracture resistance of teeth restored with these systems. Material and Method Eighty endodontically treated maxillary central incisors were sectioned perpendicular to the long axis at a point 2mm incisal to the cemento-enamel junction (CEJ) and then the root canals were obturated. The restored teeth were randomly divided into two equal groups of 40. One group was restored with Nickel-Chromium (Ni-Cr) post and core system and the other group with Non-Precious Gold alloy (NPG) system. For evaluation of fracture resistance of the restored teeth, the specimens (n=20 per each group) were mounted in acrylic resin blocks and a layer of polyvinyl siloxane was applied to cover the roots. Loads were applied at an angle of 45 degrees to the long axis of the teeth and measured with a universal testing machine. The axial retention values of the studied groups (no=20) were measured on an Instron testing machine at a crosshead speed of 0.5 mm/min. Statistical analyses were performed using SPSS version 19.00 and student’s t-test (α=0.05). Results Although retention failure load for Ni-Cr system was lower than NPG system, there was no significant difference between the two systems (p= 0.7). However, fracture resistance of the teeth restored with Ni-Cr post and core system was significantly higher than NPG group (p= 0.000). Conclusion There was no significant difference between the retention of the studied post and core systems. Although significantly higher fracture thresholds were recorded for Ni-Cr post and core group, the failure loads of both systems may rarely occur clinically. PMID:26046108

  14. Evaluation of resistance form of different preparation features on mandibular molars

    Directory of Open Access Journals (Sweden)

    Bajoghli Farshad

    2013-01-01

    Full Text Available Aims: Resistance form of full metal-ceramic crown is an important feature that determines longevity of these restorations. This study evaluated the resistance form of full metal-ceramic prepared with four different design features. Materials and Methods: An acrylic tooth was prepared with 20° total occlusal convergence (TOC angle, 2.5 mm of occlusocervical dimension and a shoulder finishing line. This design lacked resistance form. The crown preparation was subsequently modified by preparing Mesial Occlusal Distal isthmus, placing occlusal inclined plane, and reducing TOC. Four metal dies from these designs were constructed by lathe machine and then 10 metal copings were fabricated for each preparation. Metal coping were cemented on metal dies with temp-bond cement. Force was applied at 45° from lingual to buccal direction with universal testing machine. Statistical analysis used: The data were evaluated by Kruskal-Wallis and non-parametric Mann-Whitney test. Results: All features increased resistance form when compare to control group. However, reduce TOC group showed greatest value of resistance. Conclusion: Within the limitation of this study, reducing the tapering of occlusocervival dimension is the most effective way in increasing resistance form, although, other features were also effective.

  15. Gold-Pluronic core-shell nanoparticles: synthesis, characterization and biological evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Simon, Timea; Boca, Sanda [Babes-Bolyai University, Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences and Faculty of Physics (Romania); Biro, Dominic [Sapientia University, Department of Mechanical Engineering, Faculty of Technical and Human Sciences (Romania); Baldeck, Patrice [Universite Joseph Fourier and CNRS, Laboratoire Interdisciplinaire de Physique, UMR 5588, CNRS (France); Astilean, Simion, E-mail: simion.astilean@phys.ubbcluj.ro [Babes-Bolyai University, Nanobiophotonics and Laser Microspectroscopy Center, Interdisciplinary Research Institute on Bio-Nano-Sciences and Faculty of Physics (Romania)

    2013-04-15

    This study presents the synthesis of gold-Pluronic core-shell nanoparticles by a two-step method and investigates their biological impact on cancer cells, specifically nanoparticle internalization and cytotoxicity. Uniform, 9-10-nm-sized, hydrophobic gold nanoparticles were synthesized in organic phase by reducing gold salt with oleylamine, after which oleylamine-protected gold nanoparticles were phase-transferred into aqueous medium using Pluronic F127 block copolymer, resulting in gold-Pluronic core-shell nanoparticles with a mean hydrodynamic diameter of {approx}35 nm. The formation and phase-transfer of gold nanoparticles were analyzed by UV-Vis absorption spectroscopy, transmission electron microscopy, and dynamic light scattering. The obtained gold-Pluronic core-shell nanoparticles proved to be highly stable in salted solution. Cytotoxicity tests showed no modification of cellular viability in the presence of properly purified particles. Furthermore, dark-field cellular imaging demonstrated that gold-Pluronic nanoparticles were able to be efficiently uptaken by cells, being internalized through nonspecific endocytosis. The high stability, proven biocompatibility, and imaging properties of gold-Pluronic core-shell nanoparticles hold promise for relevant intracellular applications, with such a design providing the feasibility to combine all multiple functionalities in one nanoparticle for simultaneous detection and imaging.

  16. New method to evaluate optical properties of core-shell nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Renteria-Tapia, V. [Universidad de Guadalajara, Ameca, Departamento de Ciencias Naturales y Exactas, Centro Universitario de Los Valles (Mexico); Franco, A., E-mail: alfredofranco@fisica.unam.mx; Garcia-Macedo, J. [Universidad Nacional Autonoma de Mexico, Departamento de Estado Solido, Instituto de Fisica (Mexico)

    2012-06-15

    A new method is presented to calculate, for metallic core-dielectric shell nanostructures, the local refractive index, resonance condition, maximum spectral shift, plasma wavelength, and the sensitivity of the wavelength maximum to variations in the refractive index of the environment. The equations that describe these properties are directly related to the surface plasmon peak position, refractive index of the shell, and to the surrounding medium. The method is based on the approach that a layered core dispersed in a dielectric environment (core-shell model) can be figured out as an uncoated sphere dispersed in a medium with a local refractive index (local refractive index model). Thus, in the Mie theory, the same spectral position of the surface plasmon resonance peak can be obtained by varying the volume fraction of the shell or by varying the local refractive index. The assumed equivalence between plasmon resonance wavelengths enable us to show that the local refractive index depends geometrically on the shell volume fraction. Hence, simple relationships between optical and geometrical properties of these core-shell nanostructures are obtained. Furthermore, good agreement is observed between the new relationships and experimental data corresponding to gold nanoparticles (radius = 7.5 nm) covered with silica shells (with thicknesses up to 29.19 nm), which insured that the equivalence hypothesis is correct.

  17. Comparative Evaluation of a CORE Based Learning Environment for Nuclear Medicine.

    Science.gov (United States)

    Hogg, Peter; Boyle, Tom; Lawson, Richard

    1999-01-01

    Reports on a comparative assessment of a multimedia learning environment based on a guided discovery approach called CORE (Concept Object Refinement Expression) with two control conditions, lecture and electronic book, in an undergraduate radiography course. Discusses results of qualitative and quantitative measures of effectiveness, pretests and…

  18. Evaluation of the frequency of precore/core mutation in patients with chronic hepatitis B, Kerman, Southeast of Iran

    Directory of Open Access Journals (Sweden)

    Fariba Soleimani

    2016-08-01

    Full Text Available Objective: To evaluate the frequency of precore/core mutation in patients with chronic hepatitis B using PCR-restricted fragment length polymorphisms method. Methods: Sera were obtained from 69 patients with chronic hepatitis B including 30 women (43.5% and 39 men (56.5%. All patients were tested for the serum alanine aminotransferase, aspartate aminotransferase, the presence of hepatitis Be antigen and hepatitis B surface antigen by electrochemiluminescence and hepatitis B virus DNA load. Precore/core mutation was examined for the presence of a characteristic point mutation at nucleotides A1896G in precore and A1762T and G1764A in core region using nested PCR and restricted fragment length polymorphisms methods. Results: From total 69 cases with chronic hepatitis B infection, 12 (17.3% patients had precore mutation and 10 (14.4% patients had core mutation. From 69 patients, 53 (76.8% were negative for hepatitis Be antigen and 61 (88.4% were positive for hepatitis B surface antigen by electrochemiluminescence method. All samples were positive for hepatitis B virus DNA by RT-PCR. Conclusions: This study suggests that extra molecular methods should be apply for diagnosis and monitoring of mutation in chronic hepatitis B patients synchronic or serological method.

  19. Internal deformation in layered Zechstein-III K-Mg salts. Structures formed by complex deformation and high contrasts in viscosity observed in drill cores.

    Science.gov (United States)

    Raith, Alexander; Urai, Janos L.

    2016-04-01

    During the evaporation of a massive salt body, alternations of interrupted and full evaporation sequences can form a complex layering of different lithologies. Viscosity contrasts of up to five orders of magnitude between these different lithologies are possible in this environment. During the late stage of an evaporation cycle potassium and magnesium (K-Mg) salts are precipitated. These K-Mg salts are of economic interest but also a known drilling hazard due to their very low viscosity. How up to 200m thick layers of these evaporites affect salt deformation at different scales is not well known. A better understanding of salt tectonics with extreme mechanical stratification is needed for better exploration and production of potassium-magnesium salts and to predict the internal structure of potential nuclear waste repositories in salt. To gain a better understanding of the internal deformation of these layers we analyzed K-Mg salt rich drill cores out of the Zechstein III-1b subunit from the Veendam Pillow 10 km southeast of Groningen, near the city Veendam in the NE Netherlands. The study area has a complex geological history with multiple tectonic phases of extension and compression forming internal deformation in the pillow but also conserving most of the original layering. Beside halite the most common minerals in the ZIII-1b are carnallite, kieserite, anhydrite and bischofite alternating in thin layers of simple composition. Seismic interpretation revealed that the internal structure of the Veendam Pillow shows areas, in which the K-Mg salt rich ZIII 1b layer is much thicker than elsewhere, as a result of salt deformation. The internal structure of the ZIII-1b on the other hand, remains unknown. The core analysis shows a strong strain concentration in the weaker Bischofite (MgCl2*6H20) and Carnallite (KMgCl3*6H20) rich layers producing tectonic breccias and highly strained layers completely overprinting the original layering. Layers formed by alternating beds

  20. Herschel observations of B1-bS and B1-bN: two first hydrostatic core candidates in the Perseus star-forming cloud

    CERN Document Server

    Pezzuto, Stefano; Schisano, E; Strafella, F; Di Francesco, J; Sadavoy, S; André, P; Benedettini, M; Bernard, J P; di Giorgio, A M; Facchini, A; Hennemann, M; Hill, T; Könyves, V; Molinari, S; Motte, F; Nguyen-Luong, Q; Peretto, N; Pestalozzi, M; Polychroni, D; Rygl, K L J; Saraceno, P; Schneider, N; Spinoglio, L; Testi, L; Ward-Thompson, D; White, G J

    2012-01-01

    We report far-IR Herschel observations obtained between 70 $\\mu$m and 500 $\\mu$m of two star-forming dusty condensations, B1-bS and B1-bN, in the B1 region of the Perseus star-forming cloud. In the Western part of the Perseus cloud, B1-bS is the only source detected in all of the 6 PACS and SPIRE photometric bands without being visible in the Spitzer map at 24 $\\mu$m. B1-bN is clearly detected between 100 $\\mu$m and 250 $\\mu$m. We have fitted the spectral energy distributions of these sources to derive their physical properties, and find that a simple greybody model fails to reproduce the observed SEDs. At least a two-component model, consisting of a central source surrounded by a dusty envelope is required. The properties derived from the fit, however, suggest that the central source is not a Class 0 object. We then conclude that while B1-bS and B1-bN appear to be more evolved than a pre-stellar core, the best-fit models suggest that their central objects are younger than a Class 0 source. Hence, they may be...

  1. Smile design and treatment planning with the help of a comprehensive esthetic evaluation form.

    Science.gov (United States)

    Calamia, John R; Levine, Jonathan B; Lipp, Mitchell; Cisneros, George; Wolff, Mark S

    2011-04-01

    Even if a clinician possesses basic knowledge in esthetic dentistry and clinical skills, many cases presenting in modern dental practices simply cannot be restored to both the clinician's and the patient's expectations without incorporating the perspectives and assistance of several dental disciplines. Besides listening carefully to chief complaints, clinicians must also be able to evaluate the patient's physical, biologic, and esthetic needs. This article demonstrates the use of a smile evaluation form designed at New York University that assists in developing esthetic treatment plans that might incorporate any and all dental specialties in a simple and organized fashion.

  2. Antioxidant activity evaluation of new dosage forms as vehicles for dehydrated vegetables.

    Science.gov (United States)

    Romero-de Soto, María Dolores; García-Salas, Patricia; Fernández-Arroyo, Salvador; Segura-Carretero, Antonio; Fernández-Campos, Francisco; Clares-Naveros, Beatriz

    2013-06-01

    A dehydrated vegetables mixture loaded in four pharmaceutical dosage forms as powder, effervescent granulate, sugar granulate and gumdrops were investigated for their antioxidant capacity using 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging capacity assay, oxygen radical absorbance capacity assay and ferric reducing antioxidant potential assay. Total phenolic content of dehydrated vegetables powder mixture was also measured by the Folin-Ciocalteu method, so as to evaluate its contribution to their total antioxidant function. The effect of different temperatures on stability of these systems after 90 days storage was also evaluated. These formulations presented strong antioxidant properties and high phenolic content (279 mg gallic acid equivalent/g of sample) and thus could be potential rich sources of natural antioxidants. Antioxidant properties differed significantly among selected formulations (p dosage forms are new and innovative approach for vegetable intakes in population with special requirements providing an improvement in the administration of vegetables and fruits.

  3. Research Note--Should Consumers Use the Halo to Form Product Evaluations?

    OpenAIRE

    Peter Boatwright; Ajay Kalra; Wei Zhang

    2008-01-01

    In purchase situations where attribute information is either missing or difficult to judge, a well-known heuristic that consumers use to form evaluations is the halo effect. The psychology literature has widely considered the halo a reflection of consumers' inability to discriminate between different attributes and have therefore labeled it the "halo error" or the "logical error." The objective of this paper is to offer a rationale for the halo effect. We use a decision-theory framework to sh...

  4. FIRST MEASUREMENTS OF {sup 15}N FRACTIONATION IN N{sub 2}H{sup +} TOWARD HIGH-MASS STAR-FORMING CORES

    Energy Technology Data Exchange (ETDEWEB)

    Fontani, F. [INAF-Osservatorio Astrofisico di Arcetri, L.go E. Fermi 5, I-50125 Firenze (Italy); Caselli, P.; Bizzocchi, L. [Max Planck Institute for Extraterrestrial Physics, Giessenbachstrasse 1, D-85748 Garching (Germany); Palau, A. [Centro de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, P.O. Box 3-72, 58090 Morelia, Michoacán, México (Mexico); Ceccarelli, C. [Univ. Grenoble Alpes, IPAG, F-38000 Grenoble (France)

    2015-08-01

    We report on the first measurements of the isotopic ratio {sup 14}N/{sup 15}N in N{sub 2}H{sup +} toward a statistically significant sample of high-mass star-forming cores. The sources belong to the three main evolutionary categories of the high-mass star formation process: high-mass starless cores, high-mass protostellar objects, and ultracompact H ii regions. Simultaneous measurements of the {sup 14}N/{sup 15}N ratio in CN have been made. The {sup 14}N/{sup 15}N ratios derived from N{sub 2}H{sup +} show a large spread (from ∼180 up to ∼1300), while those derived from CN are in between the value measured in the terrestrial atmosphere (∼270) and that of the proto-solar nebula (∼440) for the large majority of the sources within the errors. However, this different spread might be due to the fact that the sources detected in the N{sub 2}H{sup +} isotopologues are more than those detected in the CN ones. The {sup 14}N/{sup 15}N ratio does not change significantly with the source evolutionary stage, which indicates that time seems to be irrelevant for the fractionation of nitrogen. We also find a possible anticorrelation between the {sup 14}N/{sup 15}N (as derived from N{sub 2}H{sup +}) and the H/D isotopic ratios. This suggests that {sup 15}N enrichment could not be linked to the parameters that cause D enrichment, in agreement with the prediction by recent chemical models. These models, however, are not able to reproduce the observed large spread in {sup 14}N/{sup 15}N, pointing out that some important routes of nitrogen fractionation could be still missing in the models.

  5. 48 CFR 1553.209-71 - EPA Form 1900-27, Project Officer's Evaluation of Contractor Performance.

    Science.gov (United States)

    2010-10-01

    ... Officer's Evaluation of Contractor Performance. 1553.209-71 Section 1553.209-71 Federal Acquisition... EPA Form 1900-27, Project Officer's Evaluation of Contractor Performance. As prescribed in 1509.170-4(a), EPA Form 1900-27 shall be used by the Project Officer to record his/her evaluation of...

  6. Evaluation of Heat Removal from RBMK-1500 Core Using Control Rods Cooling Circuit

    Directory of Open Access Journals (Sweden)

    A. Kaliatka

    2008-01-01

    Full Text Available The Ignalina nuclear power plant is a twin unit with two RBMK-1500, graphite moderated, boiling water, multichannel reactors. After the decision was made to decommission the Ignalina NPP, Unit 1 was shut down on December 31, 2004, and Unit 2 is to be operated until the end of 2009. Despite of this fact, severe accident management guidelines for RBMK-1500 reactor at Ignalina NPP are prepared. In case of beyond design basis accidents, it can occur that no water sources are available at the moment for heat removal from fuel channels. Specificity of RBMK reactor is such that the channels with control rods are cooled with water supplied by the system totally independent from the reactor cooling system. Therefore, the heat removal from RBMK-1500 reactor core using circuit for cooling of rods in control and protection system can be used as nonregular mean for reactor cooldown in case of BDBA. The heat from fuel channels, where heat is generated, through graphite bricks is transferred in radial direction to cooled CPS channels. This article presents the analysis of possibility to remove heat from reactor core in case of large LOCA by employing CPS channels cooling circuit. The analysis was performed for Ignalina NPP with RBMK-1500 reactor using RELAP5-3D and RELAP5 codes. Results of the analysis have shown that, in spite of high thermal inertia of graphite, this heat removal from CPS channels allows to slow down effectively the core heat-up process.

  7. Evaluation of Trapa bispinosa Roxb. starch as pharmaceutical binder in solid dosage form

    Institute of Scientific and Technical Information of China (English)

    Akhilesh V Singh; Anudwipa Singh; Lila K Nath; Nihar R Pani

    2011-01-01

    Objective: To evaluate binding efficiency of Trapa bispinosa Roxb. starch (TBS) in diclofenac sodium tablets. Methods: Diclofenac sodium tablets were prepared using wet granulation method. The starch paste in different concentrations (5%-15% w/w) was evaluated for optimized binder concentration. Preformulation study of the drug with TBS and different excipients were also analyzed using fourier transform infrared spectroscopy (FTIR) and isothermal stress testing (IST). Results: Preformulation study of the drug, water chestnut starch and different excipients showed no interaction or, drug degradation in FTIR and IST, respectively. The tablets were evaluated for hardness, friability, drug content, disintegration and dissolution studies, and all the parameters were found within the official specifications. Conclusions: The results reveal that this starch has potential to be used as binder at industrial scale in pharmaceutical solid dosage form development.

  8. Evaluation of forming limit in viscous pressure forming of automotive aluminum alloy 6k21-T4 sheet

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A ductile fracture criterion is introduced into numerical simulation to predict viscous pressure forming limit of the automotive body aluminum alloy 6k21-T4. The material constant in the ductile fracture criterion is determined by the combination of the viscous pressure bulging (VPB) test with numerical simulation. VPB tests of the aluminum alloy sheet are carried out by using various elliptical dies with different ratios of major axis to minor axis(β), and the bugling processes are simulated by the aid of the finite element method software LS-DYNA3D. On the basis of the stress and strain calculated from numerical simulations, the forming limits of bulging specimens obtained are predicted by the ductile fracture criterion, and compared with experimental results.The fracture initiation site and the minimal thickness predicted by the ductile fracture criterion are in good agreement with the experimental results.

  9. Thermodynamic evaluation of the solidification phase of molten core-concrete under estimated Fukushima Daiichi nuclear power plant accident conditions

    Science.gov (United States)

    Kitagaki, Toru; Yano, Kimihiko; Ogino, Hideki; Washiya, Tadahiro

    2017-04-01

    The solidification phases of molten core-concrete under the estimated molten core-concrete interaction (MCCI) conditions in the Fukushima Daiichi Nuclear Power Plant Unit 1 were predicted using the thermodynamic equilibrium calculation tool, FactSage 6.2, and the NUCLEA database in order to contribute toward the 1F decommissioning work and to understand the accident progression via the analytical results for the 1F MCCI products. We showed that most of the U and Zr in the molten core-concrete forms (U,Zr)O2 and (Zr,U)SiO4, and the formation of other phases with these elements is limited. However, the formation of (Zr,U)SiO4 requires a relatively long time because it involves a change in the crystal structure from fcc-(U,Zr)O2 to tet-(U,Zr)O2, followed by the formation of (Zr,U)SiO4 by reaction with SiO2. Therefore, the formation of (Zr,U)SiO4 is limited under quenching conditions. Other common phases are the oxide phases, CaAl2Si2O8, SiO2, and CaSiO3, and the metallic phases of the Fe-Si and Fe-Ni alloys. The solidification phenomenon of the crust under quenching conditions and that of the molten pool under thermodynamic equilibrium conditions in the 1F MCCI progression are discussed.

  10. Evaluating formability of LCP plate for sacral fractures with one step inverse forming finite element analysis.

    Science.gov (United States)

    Li, Xiaoda; Zhang, Xiangkui; Hu, Ping; Liu, Weijie; Shen, Guozhe; Zhan, Xianghui

    2015-01-01

    The locking compression plate fixation treatment for the unstable sacral fractures is simple and effective, with less trauma and complications. Some locking compression plate parts have been made of high-strength Plate manufactured by hot stamping process since the demand for lightweight biomedical materials. Finite Element (FE) method of One-Step inverse forming based on deformation theory is the tool to evaluate the formability of locking compression plate panel quickly in initial design for reducing costs and development cycle of Plate. But current one-step inverse forming methods are all suitable for cold stamping, not hot-stamping. This paper proposed one-step inverse forming method and workflow for hot-stamping of locking compression Plate. And the B pillar of a sacral bone was simulated and its computing result was compared with experimental value. The result shows that the proposed method in this paper can quickly evaluate high temperature formability of high-strength Plate. And the method is proposed to be used in initial design.

  11. Evaluation of Small Form Factor Fiber Optic Interconnects for the NASA Electronics Parts and Packaging Program (NEPP)

    Science.gov (United States)

    Ott, Melanie; Thomes, W. Joe; Blair, Diana; Chuska, Rick; Switzer, Rob

    2010-01-01

    The Diamond AVIM optical fiber connector has been used for over a decade in flight environments. AVIM which stands for Aviation Intermediate Maintenance is always referenced as a fiber optic connector type from the DIN (Deutsches Institut fur Normung) family of optical fiber connectors. The newly available Mini AVIM and DMI (Definition Multimedia Interface) connectors also by Diamond provide similar features as the high performance AVIM with the added benefits of being small form factor for board mount and internal box use where long connectors and strain relief can not be accommodated. Transceiver, fiber laser technology and receiver optic technology based on small sized constraints will benefit the most by the reduction in connector form factor. It is for this reason that the Mini AVIM is being evaluated for multimode and single mode optical fiber use in both fiber based and cable based packaging configurations. In a fiber based termination, there are no cable materials to bond to the connector. The only bonding that is conducted is the mounting of the fiber with epoxy to the connector ferrules (which are called DMI ferrules). In a cable configuration, the compatibility of the connector subcomponents along with the upjacketing materials of the cable around the fiber needs to be considered carefully for termination fabrication. Cabled terminations will show greater insertion loss and high probability of failures during thermal cycling testing. This is due to the stressing of the combination of materials that each have different Coefficients of Thermal Expansion (CTE's) and that are bonded together to the connector subcomponents. As the materials flex during thermal excursions, forces are applied to the termination and can make the system fail if the grouping of materials (per their CTE's) are not compatible and this includes cable materials, epoxies, ferrule and connector body components. For this evaluation, multimode 100 micron core step index fiber was used for

  12. Evaluating the scalability of HEP software and multi-core hardware

    CERN Document Server

    Jarp, S; Leduc, J; Nowak, A

    2011-01-01

    As researchers have reached the practical limits of processor performance improvements by frequency scaling, it is clear that the future of computing lies in the effective utilization of parallel and multi-core architectures. Since this significant change in computing is well underway, it is vital for HEP programmers to understand the scalability of their software on modern hardware and the opportunities for potential improvements. This work aims to quantify the benefit of new mainstream architectures to the HEP community through practical benchmarking on recent hardware solutions, including the usage of parallelized HEP applications.

  13. Artificial Neural Networks in Evaluation and Optimization of Modified Release Solid Dosage Forms

    Directory of Open Access Journals (Sweden)

    Zorica Djurić

    2012-10-01

    Full Text Available Implementation of the Quality by Design (QbD approach in pharmaceutical development has compelled researchers in the pharmaceutical industry to employ Design of Experiments (DoE as a statistical tool, in product development. Among all DoE techniques, response surface methodology (RSM is the one most frequently used. Progress of computer science has had an impact on pharmaceutical development as well. Simultaneous with the implementation of statistical methods, machine learning tools took an important place in drug formulation. Twenty years ago, the first papers describing application of artificial neural networks in optimization of modified release products appeared. Since then, a lot of work has been done towards implementation of new techniques, especially Artificial Neural Networks (ANN in modeling of production, drug release and drug stability of modified release solid dosage forms. The aim of this paper is to review artificial neural networks in evaluation and optimization of modified release solid dosage forms.

  14. Artificial neural networks in evaluation and optimization of modified release solid dosage forms.

    Science.gov (United States)

    Ibrić, Svetlana; Djuriš, Jelena; Parojčić, Jelena; Djurić, Zorica

    2012-10-18

    Implementation of the Quality by Design (QbD) approach in pharmaceutical development has compelled researchers in the pharmaceutical industry to employ Design of Experiments (DoE) as a statistical tool, in product development. Among all DoE techniques, response surface methodology (RSM) is the one most frequently used. Progress of computer science has had an impact on pharmaceutical development as well. Simultaneous with the implementation of statistical methods, machine learning tools took an important place in drug formulation. Twenty years ago, the first papers describing application of artificial neural networks in optimization of modified release products appeared. Since then, a lot of work has been done towards implementation of new techniques, especially Artificial Neural Networks (ANN) in modeling of production, drug release and drug stability of modified release solid dosage forms. The aim of this paper is to review artificial neural networks in evaluation and optimization of modified release solid dosage forms.

  15. The challenges of translating the clinical outcomes in Routine Evaluation-Outcome Measure (CORE-OM) into British Sign Language.

    Science.gov (United States)

    Rogers, Katherine D; Young, Alys; Lovell, Karina; Evans, Chris

    2013-01-01

    This article discusses translation issues arising during the production of a British Sign Language (BSL) version of the psychological outcome measure "Clinical Outcomes in Routine Evaluation-Outcome Measure" (CORE-OM). The process included forward translation, meeting with a team of translators, producing a second draft of the BSL version and back translating into English. Further modifications were made to the BSL version before piloting it with d/Deaf populations. Details of the translation process are addressed, including (a) the implications of translating between modalities (written text to visual language); (b) clarity of frequency anchors: analog versus digital encoding; (c) pronouns and the direction of signing; and (iv) the influence of the on-screen format. The discussion of item-specific issues encountered when producing a BSL version of the CORE-OM includes the expression of precise emotional states in a language that uses visual modifiers, problems associated with iconic signs, and the influence of Deaf world knowledge when interpreting specific statements. Finally, it addresses the extent to which lessons learned through this translation process are generalizable to other signed languages and spoken language translations of standardized instruments. Despite the challenges, a BSL version of the CORE-OM has been produced and found to be reliable.

  16. Au@Co0.4S core-shell nanoparticles: synthesis, characterization and evaluation of photocatalytic activity

    Science.gov (United States)

    Warjri, Wandibahun; Negi, Devendra P. S.

    2016-09-01

    In the present work, Au@Co0.4S core-shell nanoparticles were synthesized and characterized by energy-dispersive x-ray spectroscopy, transmission electron microscopy, selected area electron diffraction and diffuse reflectance spectroscopy. The photocatalytic activity of the as-prepared core-shell nanoparticles was evaluated by studying the degradation of methyl orange (MO) spectrophotometerically under visible light irradiation. Under optimum experimental conditions, 68.9% of the dye was degraded during 50 min of irradiation. Control experiments showed negligible degradation of MO in the absence of the photocatalyst under visible light irradiation. A good correlation was obtained between the concentration of the dye adsorbed on the surface of the Au@Co0.4S core-shell nanoparticles and its degradation efficiency. The as-prepared nanoparticles showed good recyclability for the degradation of MO. The mechanistic studies suggested that the valence band holes of the Co0.4S nanoparticles were scavenged by the MO molecules resulting in the degradation of the dye.

  17. Evaluation of three percent Aqueous Film Forming Foam (AFFF) concentrates as fire fighting agents

    Science.gov (United States)

    Jablonski, E. J.

    1981-04-01

    A large-scale fire test program involving 20,000-square foot JP-4 fuel fires was conducted to evaluate the fire suppression effectiveness and compatibility of 3 percent Aqueous Film Forming Foam (AFFF) agents in Air Force fire fighting vehicles. Three commercially available 3 percent AFFF concentrates were tested in accordance with military specification MIL-F-24385B. Test results are summarized in Appendix A. As a result of these tests, an updated Revision C to this MIL SPEC has been accomplished with new requirements for both 3 percent and 6 percent AFFF extinguishing agents.

  18. Glass Forming Ability of Metallic Glasses Evaluated by a New Criterion

    Institute of Scientific and Technical Information of China (English)

    CAO Qing-Ping; LI Jin-Fu; ZHOU Yao-He

    2008-01-01

    The glass-forming ability (GFA) of Cu-Zr binary alloys is evaluated using the existing criteria based on calorimetric parameters, and poor relations are found. Therefore, another parameter Trk defined as Tk/Tl, in which Tk is the Kauzmann temperature and Tl the equilibrium liquidus temperature, is proposed. It exhibits good agreements with the experimental data of the Cu-Zr system and other representative bulk metallic glass formers so long as classifying them into strong or fragile category. It is suggested that kinetic effects are irrelevantly incorporated in the GFA analysis in the previous work.

  19. Evaluation of CANDU6 PCR (power coefficient of reactivity) with a 3-D whole-core Monte Carlo Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Motalab, Mohammad Abdul; Kim, Woosong; Kim, Yonghee, E-mail: yongheekim@kaist.ac.kr

    2015-12-15

    Highlights: • The PCR of the CANDU6 reactor is slightly negative at low power, e.g. <80% P. • Doppler broadening of scattering resonances improves noticeably the FTC and make the PCR more negative or less positive in CANDU6. • The elevated inlet coolant condition can worsen significantly the PCR of CANDU6. • Improved design tools are needed for the safety evaluation of CANDU6 reactor. - Abstract: The power coefficient of reactivity (PCR) is a very important parameter for inherent safety and stability of nuclear reactors. The combined effect of a relatively less negative fuel temperature coefficient and a positive coolant temperature coefficient make the CANDU6 (CANada Deuterium Uranium) PCR very close to zero. In the original CANDU6 design, the PCR was calculated to be clearly negative. However, the latest physics design tools predict that the PCR is slightly positive for a wide operational range of reactor power. It is upon this contradictory observation that the CANDU6 PCR is re-evaluated in this work. In our previous study, the CANDU6 PCR was evaluated through a standard lattice analysis at mid-burnup and was found to be negative at low power. In this paper, the study was extended to a detailed 3-D CANDU6 whole-core model using the Monte Carlo code Serpent2. The Doppler broadening rejection correction (DBRC) method was implemented in the Serpent2 code in order to take into account thermal motion of the heavy uranium nucleus in the neutron-U scattering reactions. Time-average equilibrium core was considered for the evaluation of the representative PCR of CANDU6. Two thermal hydraulic models were considered in this work: one at design condition and the other at operating condition. Bundle-wise distributions of the coolant properties are modeled and the bundle-wise fuel temperature is also considered in this study. The evaluated nuclear data library ENDF/B-VII.0 was used throughout this Serpent2 evaluation. In these Monte Carlo calculations, a large number

  20. Targeted proteomics coming of age - SRM, PRM and DIA performance evaluated from a core facility perspective.

    Science.gov (United States)

    Kockmann, Tobias; Trachsel, Christian; Panse, Christian; Wahlander, Asa; Selevsek, Nathalie; Grossmann, Jonas; Wolski, Witold E; Schlapbach, Ralph

    2016-08-01

    Quantitative mass spectrometry is a rapidly evolving methodology applied in a large number of omics-type research projects. During the past years, new designs of mass spectrometers have been developed and launched as commercial systems while in parallel new data acquisition schemes and data analysis paradigms have been introduced. Core facilities provide access to such technologies, but also actively support the researchers in finding and applying the best-suited analytical approach. In order to implement a solid fundament for this decision making process, core facilities need to constantly compare and benchmark the various approaches. In this article we compare the quantitative accuracy and precision of current state of the art targeted proteomics approaches single reaction monitoring (SRM), parallel reaction monitoring (PRM) and data independent acquisition (DIA) across multiple liquid chromatography mass spectrometry (LC-MS) platforms, using a readily available commercial standard sample. All workflows are able to reproducibly generate accurate quantitative data. However, SRM and PRM workflows show higher accuracy and precision compared to DIA approaches, especially when analyzing low concentrated analytes.

  1. Evaluation of Jeffamine®-cored PAMAM dendrimers as an efficient in vitro gene delivery system.

    Science.gov (United States)

    Aydin, Zeynep; Akbas, Fahri; Senel, Mehmet; Koc, S Naci

    2012-10-01

    In this study, we investigated gene delivery properties of Jeffamine-cored polyamidoamine (PAMAM) dendrimers (JCPDs). The effects of dendrimer concentration, generation, and core size on the gene delivery have been analyzed. The experimental results showed that the JCPD effectively delivered plasmid DNA inside the HeLa cells, and the transfection efficiency improved considerably as the number of generation increased. The cytotoxicity of JCPD in different concentration was tested for HeLa cell line. JCPD was complexed with a lacZ gene carrying plasmid and tested for transfection efficiency using quantitative β-galactosidase expression assay. Additionally, confocal microscopy results revealed that JCPD effectively delivered green fluorescent protein-expressing plasmid into HeLa cells and produced fluorescent signal with satisfactory efficiency. The highest transfection efficiency was obtained from JCPDs G4 and G5, which mixed with expression plasmid vectors at a 10/1 weight ratio. These results indicated that under optimized conditions, JCPD can be considered as an efficient transfection reagent and can be effectively used for gene delivery applications.

  2. Comparative evaluation of compressive strength and flexural strength of conventional core materials with nanohybrid composite resin core material an in vitro study.

    Science.gov (United States)

    Jayanthi, Narasimha; Vinod, V

    2013-09-01

    Several dental materials have been used for core build-up procedures. Most of these materials were not specifically developed for this purpose, but as a consequence of their properties, have found application in core build-up procedures. Improvements in composites and the development of nanocomposites have led to their use as a core build up material due to their superior mechanical properties, optical properties and ease of handling. However it is not clear if they have better mechanical properties than the conventional core build up materials like amalgam, GIC and dual cure composite core build up material. The strength of the core material is very important and this study was undertaken to compare the mechanical properties of materials used for direct core foundations. The differences between the compressive strength and flexural strength of Filtek Z350 nanocomposite with conventional core build up materials like Amalgam, Vitremer GIC and Fluorocore were tested. Cylindrical plexi glass split molds of dimension 6 ± 1 mm [height] x4 ± 1 mm [diameter] were used to fabricate 15 samples of each core material for testing the compressive strength and rectangular plexi glass split molds of dimension 25 ± 1 mm [length] x 2 ± 1 mm[height] x2 ± 1 mm [width] used for fabricating samples for flexural strength. The samples were stored a water bath at 250 °C for 24 h before testing. The samples were tested using a Universal Instron testing machine. The results of the study showed that Fluorocore had the highest compressive strength and flexural strength followed by Filtek Z350 [nanocomposite] Amalgam had the least flexural strength and Vitremer GIC had the least compressive strength. Thus flurocore and nanocomposite are stronger than other core build up materials and hence should be preferred over other conventional core build up materials in extensively damaged teeth.

  3. Social and Emotional Competencies Evaluation Questionnaire-Teacher's Version: Validation of a Short Form.

    Science.gov (United States)

    Coelho, Vitor A; Sousa, Vanda; Marchante, Marta

    2016-08-01

    The Social and Emotional Competencies Evaluation Questionnaire-Teacher's version, Short Form (QACSE-P-SF) allows teachers to assess their students' social and emotional competencies, having been designed for program evaluation. Thirty-nine teachers completed the QACSE-P-SF, regarding 657 students (fourth to ninth grades). Factor analyses supported a six-factor structure with acceptable internal consistency. Sex differences were found with teachers reporting girls as having higher scores on Self-Control, Social Awareness, Relationship Skills, and Responsible Decision Making. Developmental differences were also found with fourth-grade students presenting higher levels of Social Awareness and Relationship Skills than older students. The final version of the QACSE-P-SF is composed by 30 items, organized into six scales and less time consuming than the previous version for teachers who need to assess full classes.

  4. A young Moon-forming giant impact at 70-110 million years accompanied by late-stage mixing, core formation and degassing of the Earth.

    Science.gov (United States)

    Halliday, Alex N

    2008-11-28

    New W isotope data for lunar metals demonstrate that the Moon formed late in isotopic equilibrium with the bulk silicate Earth (BSE). On this basis, lunar Sr isotope data are used to define the former composition of the Earth and hence the Rb-Sr age of the Moon, which is 4.48+/-0.02Ga, or 70-110Ma (million years) after the start of the Solar System. This age is significantly later than had been deduced from W isotopes based on model assumptions or isotopic effects now known to be cosmogenic. The Sr age is in excellent agreement with earlier estimates based on the time of lunar Pb loss and the age of the early lunar crust (4.46+/-0.04Ga). Similar ages for the BSE are recorded by xenon and lead-lead, providing evidence of catastrophic terrestrial degassing, atmospheric blow-off and significant late core formation accompanying the ca 100Ma giant impact. Agreement between the age of the Moon based on the Earth's Rb/Sr and the lead-lead age of the Moon is consistent with no major losses of moderately volatile elements from the Earth during the giant impact. The W isotopic composition of the BSE can be explained by end member models of (i) gradual accretion with a mean life of roughly 35Ma or (ii) rapid growth with a mean life of roughly 10Ma, followed by a significant hiatus prior to the giant impact. The former assumes that approximately 60 per cent of the incoming metal from impactors is added directly to the core during accretion. The latter includes complete mixing of all the impactor material into the BSE during accretion. The identical W isotopic composition of the Moon and the BSE limits the amount of material that can be added as a late veneer to the Earth after the giant impact to less than 0.3+/-0.3 per cent of ordinary chondrite or less than 0.5+/-0.6 per cent CI carbonaceous chondrite based on their known W isotopic compositions. Neither of these on their own is sufficient to explain the inventories of both refractory siderophiles such as platinum group

  5. Effects of person-vocation fit and core self-evaluation on career commitment of medical university students: the mediator roles of anxiety and career satisfaction.

    Science.gov (United States)

    Xiao, Wei; Zhou, Liang; Wu, Qing; Zhang, Yan; Miao, Danmin; Zhang, Jiaxi; Peng, Jiaxi

    2014-02-20

    How the career commitment of medical university students can be improved is an underinvestigated topic. This experimental study aims to explore the factors that influence career commitment of medical university students. One hundred eighty-two medical university students completed the vocational value questionnaire, state anxiety scale, core self-evaluation scale, Minnesota satisfaction questionnaire, and the Chinese career commitment questionnaire. (1) A mismatch was found between the vocational value and the medical career of medical university students, primarily in their self-development; (2) Core self-evaluation can significantly predict the continued commitment of medical university students; (3) Vocational value, career fit, and core self-evaluation can significantly predict the affective commitment and normative commitment of medical university students, while state anxiety and vocational satisfaction play significant mediating roles. Both person-vocation fit and core self-evaluation can affect the career commitment of medical university students, while job satisfaction and state anxiety play mediating roles.

  6. The Effect of Central Baryonic Cores in Dark Halos on the Evaluation of Strong Lensing Probabilities

    Institute of Scientific and Technical Information of China (English)

    Jie Wang

    2004-01-01

    We present an estimate of the strong lensing probability by dark halos, with emphasis on the role of the baryonic matter arising purely from radiative cooling. We treat the contribution of the cooled baryons optimistically with all the cooled baryons confined within a central core, and including no feedback process from stellar evolution. Our two-component model provides a strong lensing probability that is in good agreement with the observed distribution of multiple images of quasars, provided that the cooled baryons are deposited within a spherical region of radius of 0.1 times the virial radius and follow an isothermal profile. It is pointed out that strong lensing may be used as an additional probe of baryon physics in dark halos though this may meanwhile complicate the test of the inner density profiles of dark matter in halos using the observed strong lensing probability.

  7. Theoretical evaluation of the double U-core switched reluctance machine

    DEFF Research Database (Denmark)

    Jæger, Rasmus; Nielsen, Simon Staal; Rasmussen, Peter Omand

    2017-01-01

    The switched reluctance machine (SRM) has seen a lot of interest due to its simplicity and ruggedness. Much attention have been paid in academia to improve on some of the disadvantages of the technology such as torque ripple, acoustic noise and low torque density. In this paper a topology, namely...... the double U-core SRM, is reviewed. This topology improves on some of the disadvantages of the regular SRM. Torque ripple is reduced and the torque density is increased for the same amount of material, by reconfiguring the topology of the regular SRM and increasing the number of poles. The result...... is a segmented stator structure where each segment can be wound individually and assembled afterwards. Several similar technologies have been demonstrated, and the claimed advantages have been proven in comparison with regular SRMs with a lower pole count. In this paper, the technology will be compared...

  8. Evaluation of advanced cooling therapy's esophageal cooling device for core temperature control.

    Science.gov (United States)

    Naiman, Melissa; Shanley, Patrick; Garrett, Frank; Kulstad, Erik

    2016-05-01

    Managing core temperature is critical to patient outcomes in a wide range of clinical scenarios. Previous devices designed to perform temperature management required a trade-off between invasiveness and temperature modulation efficiency. The Esophageal Cooling Device, made by Advanced Cooling Therapy (Chicago, IL), was developed to optimize warming and cooling efficiency through an easy and low risk procedure that leverages heat transfer through convection and conduction. Clinical data from cardiac arrest, fever, and critical burn patients indicate that the Esophageal Cooling Device performs very well both in terms of temperature modulation (cooling rates of approximately 1.3°C/hour, warming of up to 0.5°C/hour) and maintaining temperature stability (variation around goal temperature ± 0.3°C). Physicians have reported that device performance is comparable to the performance of intravascular temperature management techniques and superior to the performance of surface devices, while avoiding the downsides associated with both.

  9. Core-in-cup tablet design of metoprolol succinate and its evaluation for controlled release.

    Science.gov (United States)

    Nagaraju, Ravouru; Meera, Durgumahanthi Sai; Kaza, Rajesh; Arvind, Vakati Venkata; Venkateswarlu, Vobalaboina

    2009-12-01

    The core-in-cup matrix tablets of Metoprolol succinate were prepared by wet granulation technique. Of all the investigated formulations, the optimized formulation of MS-09 followed zero-order kinetics of drug release. Trail on MS-09 was formulated using 7.5% hydrogenated castor-oil (HCO) and 4% of hydroxyl propyl methylcellulose (HPMC K15M) with an objective to achieve a linear release profile for 24 h. There is no initial burst release, with 16.17% of drug released during the first hour and release was extended up to 24 hrs. Study of drug release kinetics was performed by application of dissolution data to various kinetic equations like zero-order; first order, Higuchi and Korsmeyer-Peppas, from R(2) value (0.9975) it was concluded that the drug release followed zero order kinetics with both erosion and diffusion as the release mechanisms.

  10. Performance evaluation of PSO and GA in PWR core loading pattern optimization

    Energy Technology Data Exchange (ETDEWEB)

    Khoshahval, F., E-mail: f_khoshahval@sbu.ac.i [Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Velenjak, Tehran (Iran, Islamic Republic of); Minuchehr, H. [Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Velenjak, Tehran (Iran, Islamic Republic of); Zolfaghari, A., E-mail: a-zolfaghari@sbu.ac.i [Engineering Department, Shahid Beheshti University, G.C., P.O. Box 1983963113, Velenjak, Tehran (Iran, Islamic Republic of)

    2011-03-15

    Research highlights: The performance of both GA and PSO methods in optimizing of a PWR core are adequate. It seems GA arrives to its final parameter value in a fewer generation than the PSO. The computation time for GA is higher than PSO. The GA-2 and PSO-CFA algorithms perform better in comparison to GA-1 and PSO-IWA. - Abstract: The efficient operation and fuel management of PWRs are of utmost importance. Recently, genetic algorithm (GA) and particle swarm optimization (PSO) techniques have attracted considerable attention among various modern heuristic optimization techniques. GA is a powerful optimization technique, based upon the principles of natural selection and species evolution. GA is finding popularity as design tools because of its versatility, intuitiveness and ability to solve highly non-linear, mixed integer optimization problems. PSO refers to a relatively new family of algorithms and is mainly inspired by social behavior patterns of organisms that live within large group. This study addresses the application and performance comparison of PSO and GA optimization methods for nuclear fuel loading pattern problem. Flattening of power inside the reactor core of Bushehr nuclear power plant (WWER-1000 type) is chosen as an objective function to prove the validity of algorithms. In addition the performance of both optimization techniques in terms of convergence rate and computational time is compared. It is found that, from an evolutionary point of view, the performance of both GA and PSO is quite adequate. But, GA seems to arrive at its final parameter value in a fewer generations than the PSO. It is also noticed that, the computation time for implemented GA in this work is too high in comparison to PSO.

  11. Psychometric evaluation and short form development of The Balanced Inventory of Desirable Responding (BIDR-6

    Directory of Open Access Journals (Sweden)

    Subotić Siniša

    2016-01-01

    Full Text Available The goals of this research were to evaluate the Bosnian-Croatian-Serbian (BCS translation of the BIDR-6 scale, develop its short form, and to present its initial convergent/discriminative validation. The sample included 827 participants. MIRT CFA analysis revealed that fourfactor model (containing 32/40 items fits the data best, with Self-Deceptive Enhancement (SDE and Impression Management (IM both splitting into the denial (SD-D and IM-D and enhancement (SD-E and IM-E factors. Fit and item properties were generally mediocre. SD-D and IM-E subscales were the strongest sources of misfit, thus SD-E and IM-D subscales were retained in the short form, which had good fit and replicated almost all main patterns of associations with other variables of interest (e.g., HEXACO personality traits typically reported for the full SDE and IM scales in other research. Thus, 17-item BIDR-6 short form, containing only SD-E and IM-D subscales, is recommended for use in the BCS speaking area.

  12. Evaluation of Core Vocabulary Intervention for Treatment of Inconsistent Phonological Disorder: Three Treatment Case Studies

    Science.gov (United States)

    McIntosh, Beth; Dodd, Barbara

    2009-01-01

    Children with unintelligible speech differ in severity, underlying deficit, type of surface error patterns and response to treatment. Detailed treatment case studies, evaluating specific intervention protocols for particular diagnostic groups, can identify best practice for children with speech disorder. Three treatment case studies evaluated the…

  13. Evaluation of Core Vocabulary Intervention for Treatment of Inconsistent Phonological Disorder: Three Treatment Case Studies

    Science.gov (United States)

    McIntosh, Beth; Dodd, Barbara

    2009-01-01

    Children with unintelligible speech differ in severity, underlying deficit, type of surface error patterns and response to treatment. Detailed treatment case studies, evaluating specific intervention protocols for particular diagnostic groups, can identify best practice for children with speech disorder. Three treatment case studies evaluated the…

  14. Development and Test Evaluations for Ni-DOBDC Metal Organic Framework (MOF) Engineered Forms

    Energy Technology Data Exchange (ETDEWEB)

    Troy G. Garn; Mitchell Greenhalgh

    2013-07-01

    A joint effort to prepare engineered forms of a Ni-DOBDC metal organic framework (MOF) was completed with contributions from PNNL, SNL and the INL. Two independent methods were used at INL and SNL to prepare engineered form (EF) sorbents from Ni-DOBDC MOF powder developed and prepared at PNNL. Xe and Kr capacity test evaluations were performed at ambient temperature with the cryostat experimental setup at INL. The initial INL EF MOF test results indicated a Xe capacity of 1.6 mmol/kg sorbent and no Kr capacity. A large loss of surface area also occurred during minimal testing rendering the INL EF MOF unusable. Four capacity tests were completed using the SNL EF MOF at ambient temperature and resulted in Xe capacities of 1.4, 4.2, 5.0 and 3.8 mmol/kg sorbent with no Kr capacity observed in any ambient temperature tests. Two additional capacity tests were performed at 240 K to further evaluate SNL EF MOF performance. Xe capacities of 50.7 and 49.3 mmol/kg of sorbent and Kr capacities of 0.77 and 0.69 mmol/kg of sorbent were obtained, respectively. Following the adsorption evaluations, the SNL EF MOF material had lost about 40 % of the initial mass and 40 % of the initial surface area. In general, the Xe capacity results at ambient temperature for the INL and SNL EF Ni-DOBDC MOF’s were lower than 9.8 mmol Xe/kg sorbent test results reported by INL in FY-12 using PNNL’s inital EF supplied material.

  15. Content analysis of resident evaluations of faculty anesthesiologists: supervision encompasses some attributes of the professionalism core competency.

    Science.gov (United States)

    Dexter, Franklin; Szeluga, Debra; Hindman, Bradley J

    2017-05-01

    Anesthesiology departments need an instrument with which to assess practicing anesthesiologists' professionalism. The purpose of this retrospective analysis of the content of a cohort of resident evaluations of faculty anesthesiologists was to investigate the relationship between a clinical supervision scale and the multiple attributes of professionalism. From July 1, 2013 to the present, our department has utilized the de Oliveira Filho unidimensional nine-item supervision scale to assess the quality of clinical supervision of residents provided by our anesthesiologists. The "cohort" we examined included all 13,664 resident evaluations of all faculty anesthesiologists from July 1, 2013 through December 31, 2015, including 1,387 accompanying comments. Words and phrases associated with the core competency of professionalism were obtained from previous studies, and the supervision scale was analyzed for the presence of these words and phrases. The supervision scale assesses some attributes of anesthesiologists' professionalism as well as patient care and procedural skills and interpersonal and communication skills. The comments that residents provided with the below-average supervision scores included attributes of professionalism, although numerous words and phrases related to professionalism were not present in any of the residents' comments. The de Oliveira Filho clinical supervision scale includes some attributes of anesthesiologists' professionalism. The core competency of professionalism, however, is multidimensional, and the supervision scale and/or residents' comments did not address many of the other established attributes of professionalism.

  16. Development of analytical code for core disruptive accident of metallic fuel core and evaluation of upper limitation of coolant void reactivity

    Energy Technology Data Exchange (ETDEWEB)

    Ueda, Nobuyuki [Central Research Inst. of Electric Power Industry, Komae, Tokyo (Japan). Komae Research Lab

    2001-06-01

    In the event of HCDA (Hypothetical Core Damage Accident) the safety of the metallic core must be ensured. Coolant void reactivity, which produces a positive reactivity effect, must be restrained to exclude 'energetic sequence' (uncontrollable power generation). As this reactivity and the core performance are in a state of confrontation, an upper limit must be determined through safety analyses. The larger the coolant void reactivity becomes, the more the core performance improves. A core dynamics analysis code named CANIS has been developed to analysis metallic fuel properties, irradiation behavior, and transient behavior in the initiating phase of HCDA. ULOF (Unprotected Loss Of Flow) events, which are considered major HCDA initiators, are analyzed with various parameters of cladding failure conditions and molten fuel dispersion velocities. The results indicate, the cladding failure condition is the most sensitive safety parameter. The coolant void reactivity of 12$ is acceptable in the condition that cladding fails at 1,000 degC. And the upper value is limited to 8$ for the conservative condition of a 1,200 degC failure criteria. (author)

  17. Evaluation of final waste forms and recommendations for baseline alternatives to group and glass

    Energy Technology Data Exchange (ETDEWEB)

    Bleier, A.

    1997-09-01

    An assessment of final waste forms was made as part of the Federal Facilities Compliance Agreement/Development, Demonstration, Testing, and Evaluation (FFCA/DDT&E) Program because supplemental waste-form technologies are needed for the hazardous, radioactive, and mixed wastes of concern to the Department of Energy and the problematic wastes on the Oak Ridge Reservation. The principal objective was to identify a primary waste-form candidate as an alternative to grout (cement) and glass. The effort principally comprised a literature search, the goal of which was to establish a knowledge base regarding four areas: (1) the waste-form technologies based on grout and glass, (2) candidate alternatives, (3) the wastes that need to be immobilized, and (4) the technical and regulatory constraints on the waste-from technologies. This report serves, in part, to meet this goal. Six families of materials emerged as relevant; inorganic, organic, vitrified, devitrified, ceramic, and metallic matrices. Multiple members of each family were assessed, emphasizing the materials-oriented factors and accounting for the fact that the two most prevalent types of wastes for the FFCA/DDT&E Program are aqueous liquids and inorganic sludges and solids. Presently, no individual matrix is sufficiently developed to permit its immediate implementation as a baseline alternative. Three thermoplastic materials, sulfur-polymer cement (inorganic), bitumen (organic), and polyethylene (organic), are the most technologically developed candidates. Each warrants further study, emphasizing the engineering and economic factors, but each also has limitations that regulate it to a status of short-term alternative. The crystallinity and flexible processing of sulfur provide sulfur-polymer cement with the highest potential for short-term success via encapsulation. Long-term immobilization demands chemical stabilization, which the thermoplastic matrices do not offer. Among the properties of the remaining

  18. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  19. Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

    OpenAIRE

    Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

    2010-01-01

    Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

  20. Getting to the core of locus of control: Is it an evaluation of the self or the environment?

    Science.gov (United States)

    Johnson, Russell E; Rosen, Christopher C; Chang, Chu-Hsiang Daisy; Lin, Szu-Han Joanna

    2015-09-01

    Responding to criticisms surrounding the structural validity of the higher order core self-evaluations (CSE) construct, in the current study we examined the appropriateness of including locus of control as an indicator of CSE. Drawing from both theoretical and empirical evidence, we argue that locus of control is more heavily influenced by evaluations of the environment compared with the other CSE traits. Using data from 4 samples, we demonstrate that model fit for the higher order CSE construct is better when locus of control is excluded versus included as a trait indicator and that the shared variance between locus of control and CSE is nominal. This does not mean that locus of control is irrelevant for CSE theory though. We propose that evaluations of the environment moderate the relations that CSE has with its outcomes. To test this proposition, we collected data from 4 unique samples that included a mix of student and employee participants, self- and other-ratings, and cross-sectional and longitudinal data. Our results revealed that locus of control moderated relations of CSE with life and job satisfaction, and supervisor-rated job performance. CSE had stronger, positive relations with these outcomes when locus of control is internal versus external. These findings broaden CSE theory by demonstrating one way in which evaluations of the environment interface with evaluations of the self. (PsycINFO Database Record

  1. Evaluation of radcal gamma thermometers for in-core monitoring of Savannah River Site production reactors

    Energy Technology Data Exchange (ETDEWEB)

    McCulloch, R.W.; Crowley, J.L. [DELTA M Corp., Oak Ridge, TN (United States); Croft, W.D. [Westinghouse Savannah River Co., Aiken, SC (United States)

    1991-12-31

    The Savannah River Site (SRS) recently obtained a quantity of Radcal Gamma Thermometer Assemblies (RGTAs) for in-core monitoring of local power in their production reactors. The RGTAs, manufactured by DELTA M Corporation in Oak Ridge, Tennessee, contained seven Self Calibrating Gamma Thermometer (SCGT) sensors within a 7.26 mm diameter, 3.06 m length with a total length of 5.6 m. All RGTAs contained an isolated segmented heater cable for in-situ calibration. Each SCGT sensor was subjected to a 40 point calibration at discrete power levels from 0.5 to 6 watts per gram (w/g) under both joule and cable power. Calibration equations were developed from this to predict reactor power at each sensor. Additionally three units were calibrated at combined joule and cable heating conditions from 0.5 to 2.5 w/g cable and 0.5 to 6 w/g joule. A statistical analysis of all data was used to derive prediction equations that enable SRS engineers to precisely track any changes in sensor calibration throughout the lifetime of the instruments. This paper presents the detailed configuration of the 36 units manufactured for SRS, reviews the calibration results, and discusses the utility and accuracy of the statistically derived prediction equations for in-situ calibration.

  2. Evaluation of radcal gamma thermometers for in-core monitoring of Savannah River Site production reactors

    Energy Technology Data Exchange (ETDEWEB)

    McCulloch, R.W.; Crowley, J.L. (DELTA M Corp., Oak Ridge, TN (United States)); Croft, W.D. (Westinghouse Savannah River Co., Aiken, SC (United States))

    1991-01-01

    The Savannah River Site (SRS) recently obtained a quantity of Radcal Gamma Thermometer Assemblies (RGTAs) for in-core monitoring of local power in their production reactors. The RGTAs, manufactured by DELTA M Corporation in Oak Ridge, Tennessee, contained seven Self Calibrating Gamma Thermometer (SCGT) sensors within a 7.26 mm diameter, 3.06 m length with a total length of 5.6 m. All RGTAs contained an isolated segmented heater cable for in-situ calibration. Each SCGT sensor was subjected to a 40 point calibration at discrete power levels from 0.5 to 6 watts per gram (w/g) under both joule and cable power. Calibration equations were developed from this to predict reactor power at each sensor. Additionally three units were calibrated at combined joule and cable heating conditions from 0.5 to 2.5 w/g cable and 0.5 to 6 w/g joule. A statistical analysis of all data was used to derive prediction equations that enable SRS engineers to precisely track any changes in sensor calibration throughout the lifetime of the instruments. This paper presents the detailed configuration of the 36 units manufactured for SRS, reviews the calibration results, and discusses the utility and accuracy of the statistically derived prediction equations for in-situ calibration.

  3. Recommendations for excision following core needle biopsy of the breast: a contemporary evaluation of the literature.

    Science.gov (United States)

    Calhoun, Benjamin C; Collins, Laura C

    2016-01-01

    Pathologists frequently encounter non-malignant histological findings in percutaneous core needle biopsies (CNBs). Standards for the management of patients with lesions such as atypical ductal hyperplasia, atypical lobular hyperplasia, and lobular carcinoma in situ, as well as other benign lesions, are not well defined, and recommendations for surgical biopsy or continued clinical and radiological follow-up are inconsistent. The frequency with which these lesions are 'upgraded' to carcinoma in excision specimens is widely variable in the literature. Many CNB studies lack careful radiological-pathological correlation, clear criteria for excision, and clinical follow-up for patients on whom excision was not performed. This review of the recent literature emphasizes studies with radiological-pathological correlation, with the goal of developing a contemporary, evidence-based approach to the management of non-malignant lesions of the breast diagnosed on CNB. The data supporting an emerging consensus on which lesions may not require excision are highlighted. The management of non-malignant lesions diagnosed on magnetic resonance imaging-guided CNB is also discussed.

  4. Linking of the Patient Rated Elbow Evaluation (PREE) and the American Shoulder and Elbow Surgeons - Elbow questionnaire (pASES-e) to the International Classification of Functioning Disability and Health (ICF) and Hand Core Sets.

    Science.gov (United States)

    Vincent, Joshua I; MacDermid, Joy C; King, Graham J W; Grewal, Ruby

    2015-01-01

    Content analysis-ICF linking. The Patient Rated Elbow Evaluation (PREE) and the self-report section of the American Shoulder and Elbow Surgeons society - Elbow form (ASES-e) are the two commonly used elbow pain and disability self-report measures (PROs). The content of these questions have never been analyzed in light of the International Classification of Functioning Disability and Health (ICF) which is the current standard to describe health and health-related states. The purposes of this study were to analyze the conceptual basis of the PREE and the ASES-e by linking the meaningful concepts in these PROs to the ICF using standardized linking rules and to determine the extent to which the ICF core set for hand conditions cover the content of elbow questionnaires using summary ICF linkage indicators. Two raters linked the two PROs to the ICF using the linking rules proposed by Cieza and colleagues. Percentage agreement was calculated between the raters. Summary linkage indicators proposed by MacDermid were used to estimate the extent to which the ICF core set for hand conditions cover the content of the elbow questionnaires. All the items of the PREE (Measure to ICF linkage - 100%) and all but one item of the pASES-e (Measure to ICF linkage - 95%) were linked to the ICF. The satisfaction item on the ASES-e was not-covered by the ICF. Percentage agreement on linking between the raters was 96% and 95% for the PREE and the pASES-e respectively. The unique linkage of the PREE and the pASES-e to the unique codes on the brief and comprehensive core set were lower than absolute linkage to the core set for hand conditions. The PROs represented less than 20% of the comprehensive core set and more than 70% of the brief core set. While for the unique core set disability representation the 2 PROMs represented 100% brief core set unique disability codes and less than 35% of the comprehensive core set unique disability codes. The PREE and the ASES-e are aligned with the ICF

  5. Evaluation of electronic databases used to identify solid oral dosage forms.

    Science.gov (United States)

    Raschke, Carol G; Hatton, Randy C; Weaver, S Jay; Belgado, Bernadette S

    2003-09-01

    The ability of electronic drug identification databases to identify solid oral dosage forms by their imprint codes was studied. The following seven commercially available electronic drug identification databases were selected to identify 500 solid oral dosage forms by their imprint codes: Clinical Pharmacology (Gold Standard Media, Tampa, FL), eFacts (Facts and Comparison, St. Louis, MO), Ident-A-Drug (Therapeutic Research, Stockton, CA), Identidex (Micromedex, Greenwood Village, CO), Clinical Reference Library (Lexi-Comp, Hudson, OH), Physicians' Desk Reference (PDR) Electronic Library (Medical Economics, Montvale, NJ), and RxList (RxList LLC, San Francisco, CA), Chi-square test was used to compare the percentages of medications identified by each of the seven electronic references. The ability of the databases to identify medication by specific characteristics, such as brand name versus generic, prescription versus nonprescription, commercially available for more than one year versus less than one year, colored versus white drug products, and controlled versus noncontrolled substances was evaluated. A logistic regression model was used to determine the probability of a drug product being identified by one of the electronic references based on these characteristics. All seven electronic databases combined identified 95.6% of the unknown medications by imprint code, color, shape, and scoring. Ident-A-Drug and Identidex identified the most drugs. The PDR Electronic Library and Facts and Comparisons Identified the least number of drugs. Solid oral dosage forms more likely to be identified were those that were on the market for more than a year, brand-name products, and prescription medications. Generic products on the market for less than a year and nonprescription products were particularly difficult to identify. A combination of electronic drug identification databases provides the best method of drug identification in an institutional setting.

  6. Validation of GAMMA+ model for Evaluating Heat Transfer of VHTR core in Accident Conditions by CFD analysis

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Dongho; Yoon, Sujong; Park, Gooncherl; Cho, Hyoungkyu [Seoul National Univ., Seoul (Korea, Republic of)

    2013-05-15

    KAERI has established a plan to demonstrate massive production of hydrogen using a VHTR by the early 2020s. In addition the GAMMA+ code is developed to analyze VHTR thermo-fluid transients at KAERI. One of the candidate reactor designs for VHTR is prismatic modular reactor (PMR), of which reference reactor is the 600MWth GT-MHR. This type of reactor has a passive safety system. During the High Pressure Conduction Cooling (HPCC) or Low Pressure Conduction Cooling (LPCC) accident, the core heats up by decay heat and then starts to cool down by conduction and radiation cooling to the Reactor Cavity Cooling System (RCCS) through the prismatic core. In this mechanism, the solid conduction occurs in graphite and fuel blocks, and the gas conduction and radiation occurs in coolant holes and bypass gaps. It is important to predict conduction and radiation heat transfer in the core for safety analysis. Effective thermal conductivity is derived by Maxwell's far-field methodology Radiation effect is expressed as corresponding conductivity and added to gas conductivity. In this study, ETC model used in GAMMA+ code is validated with the commercial CFD code, CFX-13. In this study, the effective thermal conductivity model of the GAMMA+ was evaluated by comparison of CFD analysis. The CFD analysis was conducted for various numbers and volume fractions of coolant holes and temperatures. Although slight disagreement was shown for the cases run with small number of holes, the result of GAMMA+ model is accurate for the large numbers of holes sufficiently. Since there are 102 coolant holes and 210 fuel holes in a fuel block, it is concluded that GAMMA+ model is proper formula for predicting effective thermal conductivity of the VHTR fuel block. However, in high temperature region above 500 .deg. C, the GAMMA+ model underestimates the effective thermal conductivity since radiation heat transfer is not reflected precisely. Further researches on it seem to be necessary.

  7. Towards real-time cardiovascular magnetic resonance guided transarterial CoreValve implantation: in vivo evaluation in swine

    Directory of Open Access Journals (Sweden)

    Kahlert Philipp

    2012-03-01

    Full Text Available Abstract Background Real-time cardiovascular magnetic resonance (rtCMR is considered attractive for guiding TAVI. Owing to an unlimited scan plane orientation and an unsurpassed soft-tissue contrast with simultaneous device visualization, rtCMR is presumed to allow safe device navigation and to offer optimal orientation for precise axial positioning. We sought to evaluate the preclinical feasibility of rtCMR-guided transarterial aortic valve implatation (TAVI using the nitinol-based Medtronic CoreValve bioprosthesis. Methods rtCMR-guided transfemoral (n = 2 and transsubclavian (n = 6 TAVI was performed in 8 swine using the original CoreValve prosthesis and a modified, CMR-compatible delivery catheter without ferromagnetic components. Results rtCMR using TrueFISP sequences provided reliable imaging guidance during TAVI, which was successful in 6 swine. One transfemoral attempt failed due to unsuccessful aortic arch passage and one pericardial tamponade with subsequent death occurred as a result of ventricular perforation by the device tip due to an operating error, this complication being detected without delay by rtCMR. rtCMR allowed for a detailed, simultaneous visualization of the delivery system with the mounted stent-valve and the surrounding anatomy, resulting in improved visualization during navigation through the vasculature, passage of the aortic valve, and during placement and deployment of the stent-valve. Post-interventional success could be confirmed using ECG-triggered time-resolved cine-TrueFISP and flow-sensitive phase-contrast sequences. Intended valve position was confirmed by ex-vivo histology. Conclusions Our study shows that rtCMR-guided TAVI using the commercial CoreValve prosthesis in conjunction with a modified delivery system is feasible in swine, allowing improved procedural guidance including immediate detection of complications and direct functional assessment with reduction of radiation and omission of contrast media.

  8. Evaluation of Selected Resource Allocation and Scheduling Methods in Heterogeneous Many-Core Processors and Graphics Processing Units

    Directory of Open Access Journals (Sweden)

    Ciznicki Milosz

    2014-12-01

    Full Text Available Heterogeneous many-core computing resources are increasingly popular among users due to their improved performance over homogeneous systems. Many developers have realized that heterogeneous systems, e.g. a combination of a shared memory multi-core CPU machine with massively parallel Graphics Processing Units (GPUs, can provide significant performance opportunities to a wide range of applications. However, the best overall performance can only be achieved if application tasks are efficiently assigned to different types of processor units in time taking into account their specific resource requirements. Additionally, one should note that available heterogeneous resources have been designed as general purpose units, however, with many built-in features accelerating specific application operations. In other words, the same algorithm or application functionality can be implemented as a different task for CPU or GPU. Nevertheless, from the perspective of various evaluation criteria, e.g. the total execution time or energy consumption, we may observe completely different results. Therefore, as tasks can be scheduled and managed in many alternative ways on both many-core CPUs or GPUs and consequently have a huge impact on the overall computing resources performance, there are needs for new and improved resource management techniques. In this paper we discuss results achieved during experimental performance studies of selected task scheduling methods in heterogeneous computing systems. Additionally, we present a new architecture for resource allocation and task scheduling library which provides a generic application programming interface at the operating system level for improving scheduling polices taking into account a diversity of tasks and heterogeneous computing resources characteristics.

  9. Head-camera video recordings of trauma core competency procedures can evaluate surgical resident's technical performance as well as colocated evaluators.

    Science.gov (United States)

    Mackenzie, Colin F; Pasley, Jason; Garofalo, Evan; Shackelford, Stacy; Chen, Hegang; Longinaker, Nyaradzo; Granite, Guinevere; Pugh, Kristy; Hagegeorge, George; Tisherman, Samuel A

    2017-07-01

    Unbiased evaluation of trauma core competency procedures is necessary to determine if residency and predeployment training courses are useful. We tested whether a previously validated individual procedure score (IPS) for individual procedure vascular exposure and fasciotomy (FAS) performance skills could discriminate training status by comparing IPS of evaluators colocated with surgeons to blind video evaluations. Performance of axillary artery (AA), brachial artery (BA), and femoral artery (FA) vascular exposures and lower extremity FAS on fresh cadavers by 40 PGY-2 to PGY-6 residents was video-recorded from head-mounted cameras. Two colocated trained evaluators assessed IPS before and after training. One surgeon in each pretraining tertile of IPS for each procedure was randomly identified for blind video review. The same 12 surgeons were video-recorded repeating the procedures less than 4 weeks after training. Five evaluators independently reviewed all 96 randomly arranged deidentified videos. Inter-rater reliability/consistency, intraclass correlation coefficients were compared by colocated versus video review of IPS, and errors. Study methodology and bias were judged by Medical Education Research Study Quality Instrument and the Quality Assessment of Diagnostic Accuracy Studies criteria. There were no differences (p ≥ 0.5) in IPS for AA, FA, FAS, whether evaluators were colocated or reviewed video recordings. Evaluator consistency was 0.29 (BA) - 0.77 (FA). Video and colocated evaluators were in total agreement (p = 1.0) for error recognition. Intraclass correlation coefficient was 0.73 to 0.92, dependent on procedure. Correlations video versus colocated evaluations were 0.5 to 0.9. Except for BA, blinded video evaluators discriminated (p competency. Prognostic study, level II.

  10. FORMULATION DEVELOPMENT AND EVALUATION OF CLARITHROMYCIN ORAL DOSAGE FORM AGAINST HELICOBACTER PYLORI INFECTION

    Directory of Open Access Journals (Sweden)

    Singh Pranjal Kumar

    2012-04-01

    Full Text Available There is keen interest in developing improved drug delivery systems to gastro intestinal tract for treatment of H. pylori induced peptic and duodenal ulcers, in the present study an attempt has been made to develop and evaluate gastroretentive matrix tablets of clarithromycin which were prepared by using Hydroxypropyl Methylcellulose K4M (HPMC K4M, Hydroxy Propyl Methyl Cellulose K15M (HPMC K15M and Hydroxypropyl Methylcellulose K100M (HPMC K100M with NaHCO3 as gas forming agent. Tablets were prepared by direct compression using directly compressible polymers such as HPMC K4M, HPMC K15M and HPMC K100M and were evaluated for drug - excipient compatibility, buoyancy test, tablet density, drug content and in-vitro release profile. Sodium bicarbonate was used for producing effervescent base for buoyancy of tablets. The release rate determined in 0.1 N HCL (pH 1.2 showed controlled release of drug following non-Fickian mechanism.

  11. FORMULATION AND EVALUATION OF ORAL CONTROLLED RELEASE DOSAGE FORM OF ANTI-HYPERTENSIVE AGENT

    Directory of Open Access Journals (Sweden)

    Lakshmi Parvathi A

    2012-12-01

    Full Text Available The aim of present investigation is preparation, characterization and evaluation of oral controlled release matrix tablets of Propranolol HCl in order to improve efficacy and to reduce the side effects. Tablets were prepared by direct compression method using different polymers like Guar gum, HPMC K4M, PVP and MCC used as the directly compressible vehicle. The granules were evaluated for pre-formulation characteristics and the tablets were subjected to post compression parameters, drug content and in-vitro dissolution release studies. In-vitro dissolution studies were carried out for 12 hrs and the results showed that among the nine formulations F8 and F9 showed good dissolution profile to control the drug release respectively. The drug release follows first order kinetics and the mechanism was found to be diffusion controlled for all the formulations (except F-9. The mechanism of drug release from F-9 was diffusion coupled with erosion. The Stability studies were carried out according to ICH guideline which indicates that the selected formulations (F8 and F9 were stable. In conclusion the results suggest that the developed matrix tablets of Propranolol HCl could perform therapeutically better than conventional dosage form, leading to improved efficacy and better patient compliance.

  12. Formulation and in vitro evaluation of sustained release dosage form with taste masking of metformin hydrochloride

    Directory of Open Access Journals (Sweden)

    Bhoyar P

    2010-01-01

    Full Text Available An attempt was made to sustain the release of metformin HCl as well as to mask the bitter taste by complexation technique using strong cation-exchange resins, indion 244 and indion 264. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug:resin and temperature. The resinate was evaluated for micromeritic properties, taste masking and characterized using XRPD and IR. Using resinate sustained release tablets were formulated using hydoxypropylmethylcellulose K100M.The tablets were evaluated for hardness, thickness, friability, drug content, weight variation and in vitro drug release. Tablets thus formulated (Batch B-6 provided sustained release of drug over a period of 10 h with first order kinetics. The release of metformin HCl from resinate controls the diffusion of drug molecules through the polymeric material into aqueous medium. Results showed that metformin HCl was successfully taste masked and formulated into a sustained dosage form as an alternative to the conventional tablet.

  13. Wear rate evaluation of a novel polycarbonate-urethane cushion form bearing for artificial hip joints.

    Science.gov (United States)

    Elsner, Jonathan J; Mezape, Yoav; Hakshur, Keren; Shemesh, Maoz; Linder-Ganz, Eran; Shterling, Avi; Eliaz, Noam

    2010-12-01

    There is growing interest in the use of compliant materials as an alternative to hard bearing materials such as polyethylene, metal and ceramics in artificial joints. Cushion form bearings based on polycarbonate-urethane (PCU) mimic the natural synovial joint more closely by promoting fluid-film lubrication. In the current study, we used a physiological simulator to evaluate the wear characteristics of a compliant PCU acetabular buffer, coupled against a cobalt-chrome femoral head. The wear rate was evaluated over 8 million cycles gravimetrically, as well as by wear particle isolation using filtration and bio-ferrography (BF). The gravimetric and BF methods showed a wear rate of 9.9-12.5mg per million cycles, whereas filtration resulted in a lower wear rate of 5.8mg per million cycles. Bio-ferrography was proven to be an effective method for the determination of wear characteristics of the PCU acetabular buffer. Specifically, it was found to be more sensitive towards the detection of wear particles compared to the conventional filtration method, and less prone to environmental fluctuations than the gravimetric method. PCU demonstrated a low particle generation rate (1-5×10⁶ particles per million cycles), with the majority (96.6%) of wear particle mass lying above the biologically active range, 0.2-10μm. Thus, PCU offers a substantial advantage over traditional bearing materials, not only in its low wear rate, but also in its osteolytic potential.

  14. Coupled analysis of core thermal hydraulics and fuel performance to evaluate a thermally induced fuel failure in an SFR subassembly

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Sun Rock; Chang, Doo Soo; Kim, Sang Ji [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    A limiting factor analysis in a core thermal design is highly important to assure the safe and reliable operation of a reactor system. In a sodium cooled fast reactor (SFR), the coolant thermal conductivity is about hundreds of times larger than the thermal conductivity of water. Moreover, the coolant boiling temperature in an SFR is around 900 .deg. C, which is much higher than that of the water coolant in a PWR. Considering typical operating temperatures, an SFR has about a 300 .deg. C thermal margin to its boiling point. Therefore, instead of DNBR (Departure from Nucleate Boiling Ratio) in a PWR, the core thermal design of SFRs requires assuring proper fuel performance and safety, where the design limits are highly related to the temperature distribution and material behavior under various operating conditions. Typical limiting factors in SFRs are the thermal component of the plastic hoop strain, radial primary hoop stress, and cumulative damage factor during normal operation. However, the previous fuel performance codes only evaluate a single fuel pin performance, which neglects the radial peaking factors and reveals too conservative results. In this work, the multi physics analysis is performed using both thermalhydraulic and fuel performance codes.

  15. Formulation and in vitro evaluation of coconut oil-core cationic nanocapsules intended for vaginal delivery of clotrimazole.

    Science.gov (United States)

    Santos, Sara S; Lorenzoni, Alessandra; Pegoraro, Natháli S; Denardi, Laura B; Alves, Sydney H; Schaffazick, Scheila R; Cruz, Letícia

    2014-04-01

    The objective of this work was to propose coconut oil-core nanocapsules prepared from Eudragit(®) RS100, a cationic polymer, and to evaluate their potential for vaginal delivery of clotrimazole in candidiasis. Nanocapsule suspensions loaded with clotrimazole at 1.0 and 3.0mg/mL were prepared by interfacial deposition of Eudragit(®) RS100. The physicochemical characterization showed average diameter lower than 200 nm, low polydispersity index, positive zeta potential (+10.94 to +14.57 mV), acid pH values (5.4-5.7) and encapsulation efficiencies close to 100%. After 60 days of storage at room temperature and protected from light, the nanocapsules were reasonably stable. Photodegradation studies showed that nanoencapsulation improved clotrimazole stability against UV radiation. The in vitro drug release at pH 4.5 was characterized by a prolonged release with no burst effect. The nanocapsules were more active than free clotrimazole against Candida albicans and Candida glabrata strains susceptible and resistant to fluconazole. Hence, clotrimazole-loaded coconut oil-core nanocapsules represent promising alternatives to the treatment of vulvovaginal candidiasis.

  16. Residual stress evaluation and curvature behavior of aluminium 7050 peen forming processed; Avaliacao da tensao residual em aluminio 7050 conformado pelo processo peen forming

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, R.R. de; Lima, N.B., E-mail: rolivier@ipen.b, E-mail: nblima@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Braga, A.P.V.; Goncalves, M., E-mail: anapaola@ipt.b, E-mail: mgoncalves@ipt.b [Instituto de Pesquisas Tecnologicas (IPT), Sao Paulo, SP (Brazil)

    2010-07-01

    Shot peening is a superficial cold work process used to increase the fatigue life evaluated by residual stress measurements. The peen forming process is a variant of the shot peening process, where a curvature in the plate is obtained by the compression of the grains near to the surface. In this paper, the influence of the parameters such as: pressure of shot, ball shot size and thickness of aluminum 7050 samples with respect to residual stress profile and resulting arc height was studied. The evaluation of the residual stress profile was obtained by sin{sup 2} {Psi} method. (author)

  17. Evaluation of Hybrid Reinforcement (Fiber-Reinforced-Plastic Rod with Steel Core)

    Science.gov (United States)

    1993-08-01

    Kaci, S. (1992), "Cables Composites pour la Precontrainte : Etude de la Relaxation," Advanced Composite Materials in Bridges and Structures, 1st...Nishizaki, I., Sasaki, I. (1992), "Evaluation of the Durability of Advanced Composites for Applications to Prestressed Concrete Bridges ," Advanced...7:4 z ... ýs (*AA4 - 2-0 4 Theodor Krauthammer Professor of Civil Engineering ABSTRACT The corrosion of concrete reinforcement is a problem that

  18. Core Self-Evaluations and Job and Life Satisfaction: The Mediating and Moderated Mediating Role of Job Insecurity.

    Science.gov (United States)

    Hsieh, Hui-Hsien; Huang, Jie-Tsuen

    2017-04-03

    This study examined the mediating role of job insecurity in the relationship between core self-evaluations (CSE) and job satisfaction, while also investigating the moderating role of job insecurity in the mediated relationship between CSE and life satisfaction via job satisfaction. Survey data were collected from a sample of 346 full-time employees in Taiwan. We found that job insecurity partially mediated the CSE-job satisfaction relationship. Moreover, we found that job insecurity moderated not only the relationship between CSE and job satisfaction but also the mediated relationship between CSE and life satisfaction via job satisfaction. Specifically, both the CSE-job satisfaction relationship and the CSE-job satisfaction-life satisfaction relationship became stronger when job insecurity was low. Our results emphasize the importance of raising employees' CSE, which is beneficial not only for diminishing their perceptions of job insecurity, but also for boosting their job and life satisfaction. Practical implications and directions for future research are discussed.

  19. Loss of Coolant Accident (LOCA) / Emergency Core Coolant System (ECCS Evaluation of Risk-Informed Margins Management Strategies for a Representative Pressurized Water Reactor (PWR)

    Energy Technology Data Exchange (ETDEWEB)

    Szilard, Ronaldo Henriques [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    A Risk Informed Safety Margin Characterization (RISMC) toolkit and methodology are proposed for investigating nuclear power plant core, fuels design and safety analysis, including postulated Loss-of-Coolant Accident (LOCA) analysis. This toolkit, under an integrated evaluation model framework, is name LOCA toolkit for the US (LOTUS). This demonstration includes coupled analysis of core design, fuel design, thermal hydraulics and systems analysis, using advanced risk analysis tools and methods to investigate a wide range of results.

  20. Aesthetic result after breast-conserving therapy is associated with quality of life several years after treatment. Swedish women evaluated with BCCT.core and BREAST-Q™.

    Science.gov (United States)

    Dahlbäck, Cecilia; Ullmark, Jenny Heiman; Rehn, Martin; Ringberg, Anita; Manjer, Jonas

    2017-08-01

    A gold standard for evaluation of aesthetic outcome after breast-conserving therapy (BCT) is still lacking. The BCCT.core software has been developed to assess aesthetic result in a standardised way. We aimed to study how the result of BCCT.core after BCT is associated with quality of life, measured with the BREAST-Q™, a validated questionnaire. Women eligible for BCT were consecutively recruited between February 1st 2008 and January 31st 2012 (n = 653). Photographs of 310 women, taken one year after BCT, were evaluated using the BCCT.core software. The postoperative BCT module of the BREAST-Q™ questionnaire was administered by mail and 348 questionnaires were returned (median 5.5 years after BCT). In all, 216 women had both BCCT.core results and completed BREAST-Q™ questionnaires available. The results from the BCCT.core evaluation were: excellent n = 49 (15.8%); good n = 178 (57.4%); fair n = 73 (23.5%); poor n = 10 (3.2%). The median BREAST-Q™ score for satisfaction with breasts was 66 [interquartile range (IQR) 57-80] and for psychosocial well-being 82 (IQR 61-100). Poor/fair results on BCCT.core were associated with Q-scores below median for both satisfaction with breasts [odds ratio (OR) 3.4 (confidence interval (CI) 1.7-6.8)] as well as for psychosocial well-being [OR 2.2 (CI 1.1-4.2)]. A statistically significant association between BCCT.core results one year after BCT and quality of life ratings using BREAST-Q™ several years later is shown in this study. This implies that the BCCT.core may be valuable in BCT follow-up and used as a standardised instrument in the evaluation of aesthetic results.

  1. Evaluation of a new wide pore core-shell material (Aeris WIDEPORE) and comparison with other existing stationary phases for the analysis of intact proteins.

    Science.gov (United States)

    Fekete, Szabolcs; Berky, Róbert; Fekete, Jenő; Veuthey, Jean-Luc; Guillarme, Davy

    2012-05-04

    The separation of large biomolecules such as proteins or monoclonal antibodies (mAbs) by RPLC can be drastically enhanced thanks to the use of columns packed with wide-pore porous sub-2 μm particles or shell particles. In this context, a new wide-pore core-shell material has been recently released under the trademark Aeris WIDEPORE. It is made of a 3.2 μm solid inner core surrounded by a 0.2 μm porous layer (total particle size of 3.6 μm). The aim of this study was to evaluate the performance of this new material, compare it to other recently developed and older conventional wide-pore columns and demonstrate its applicability to real-life separations of proteins and mAbs. At first, the traditional h(min) values of the Aeris WIDEPORE column were determined for small model compounds. The h(min) values were equal to 1.7-1.8 and 1.4 for the 2.1 and 4.6 mm I.D. columns, respectively, which are in agreement with the values reported for other core-shell materials. In the case of a small protein Insulin (5.7 kDa), the achievable lowest h value was below 2 and this impressive result confirms that the Aeris WIDEPORE material should be dedicated to protein analysis. This column was then compared with five other commercially available wide-pore and medium-pore stationary phases, in the gradient elution mode, using various flow rates, gradient steepness and model proteins of MW=5.7-66.8 kDa. The Aeris WIDEPORE material often provided the best performance, in terms of peak capacity, peak capacity per time and pressure unit (PPT) and also based on the gradient kinetic plot representation. Finally, real separations of filgrastim (18.8 kDa) and its oxidized and reduced forms were performed on the different columns and the Aeris WIDEPORE material provided the most impressive performance (peak capacity>100 for t(grad)material was also evaluated on digested and reduced mAb and powerful, high-throughput separations were also attained.

  2. Evaluating the internalisation of core values at a South African public service organisation

    Directory of Open Access Journals (Sweden)

    Susanna M. O’Neil

    2012-01-01

    Full Text Available Orientation: Fully entrenched and internalised organisational values have proved a competitive advantage for many leading organisations. The benefits range from higher profit margins to the improvement of employees’ commitment and ethical performance. Nevertheless, the process of value shaping is often no more than a management goal. It is rarely truly internalised by the whole organisation.Research purpose: This article presents an effort to describe a value internalisation effort within a South African public service organisation as well as the results of a subsequent evaluation to ascertain to what extent those efforts actually led to internalisation throughout the organisation. A set of actions and practices were implemented within the public service organisation; the intent was that they should enhance value internalisation in the organisation. A long-term strategy of value internalisation was followed that focussed mainly on the clear articulation and communication of the values through different communication mediums and platforms, such as road shows and branded value material hand-outs, as well as through extensive value internalisation training.Motivation for the study: Documentation of value internalisation processes and its evaluation, especially in South African public service organisations is extremely rare. To ensure that public service organisations do not repeat the same mistakes in their value internalisation practices and implementation processes, proper documentation of these processes in the public and research domains are needed. The need for the evaluation of value internalisation programmes should also be propagated as in many instances, programmes are implemented, but the subsequent success thereof is never evaluated.Research design, approach and method: A survey questionnaire consisting of a 5-point rating scale was developed to measure the extent of value internalisation after the implementation of long

  3. Core Self-Evaluations as Personal Factors in the World Health Organization's International Classification of Functioning, Disability and Health Model: An Application in Persons with Spinal Cord Injury

    Science.gov (United States)

    Yaghmanian, Rana; Smedema, Susan Miller; Thompson, Kerry

    2017-01-01

    Purpose: To evaluate Chan, Gelman, Ditchman, Kim, and Chiu's (2009) revised World Health Organization's International Classification of Functioning, Disability and Health (ICF) model using core self-evaluations (CSE) to account for Personal Factors in persons with spinal cord injury (SCI). Method: One hundred eighty-seven adults with SCI were…

  4. Evaluation of various properties of alternative salt forms of sulfobutylether-beta-cyclodextrin, (SBE)7M-beta-CD.

    Science.gov (United States)

    Sotthivirat, S; Haslam, J L; Stella, V J

    2007-02-07

    The goal of this study was to evaluate alternative salt forms of (SBE)7M-beta-CD (currently the sodium salt). The potential salt form would ideally decrease the rate of (SBE)7M-beta-CD release from osmotic pump formulations and result in an increase in the rate and extent of drug release in osmotic pump tablet and pellet dosage forms. Several (SBE)7M-beta-CD salt forms (potassium, calcium, and two ethylene diamine salt forms) were prepared by either titration or ultrafiltration and characterized by elemental analysis and capillary electrophoresis, CE. The physical properties (water uptake behavior, osmolality, complexation characteristics, etc.) were then compared to the sodium salt form. Although the water isotherm and the binding characteristics using various model drugs were similar among all the salt forms, the calcium salt form appeared to be the best alternative candidate due to its lower osmolality and slower intrinsic dissolution rate.

  5. Measuring the Internal Structure and Physical Conditions in Star and Planet Forming Clouds Core: Toward a Quantitative Description of Cloud Evolution

    Science.gov (United States)

    Lada, Charles J.

    2005-01-01

    This grant funds a research program to use infrared extinction measurements to probe the detailed structure of dark molecular cloud cores and investigate the physical conditions which give rise to star and planet formation. The goals of this program are to acquire, reduce and analyze deep infrared and molecular-line observations of a carefully selected sample of nearby dark clouds in order to internal structure of starless cloud cores and to quantitatively investigate the evolution of such structure through the star and planet formation process. During the second year of this grant, progress toward these goals is discussed.

  6. Measuring the Internal Structure and Physical Conditions in Star and Planet Forming Clouds Cores: Towards a Quantitative Description of Cloud Evolution

    Science.gov (United States)

    Lada, Charles J.

    2004-01-01

    This grant funds a research program to use infrared extinction measurements to probe the detailed structure of dark molecular cloud cores and investigate the physical conditions which give rise to star and planet formation. The goals of this program are to acquire, reduce and analyze deep infrared and molecular-line observations of a carefully selected sample of nearby dark clouds in order to determine the detailed initial conditions for star formation from quantitative measurements of the internal structure of starless cloud cores and to quantitatively investigate the evolution of such structure through the star and planet formation process.

  7. Initial Evaluation of Processing Methods for an Epsilon Metal Waste Form

    Energy Technology Data Exchange (ETDEWEB)

    Crum, Jarrod V.; Strachan, Denis M.; Zumhoff, Mac R.

    2012-06-11

    During irradiation of nuclear fuel in a reactor, the five metals, Mo, Pd, Rh, Ru, and Tc, migrate to the fuel grain boundaries and form small metal particles of an alloy known as epsilon metal ({var_epsilon}-metal). When the fuel is dissolved in a reprocessing plant, these metal particles remain behind with a residue - the undissolved solids (UDS). Some of these same metals that comprise this alloy that have not formed the alloy are dissolved into the aqueous stream. These metals limit the waste loading for a borosilicate glass that is being developed for the reprocessing wastes. Epsilon metal is being developed as a waste form for the noble metals from a number of waste streams in the aqueous reprocessing of used nuclear fuel (UNF) - (1) the {var_epsilon}-metal from the UDS, (2) soluble Tc (ion-exchanged), and (3) soluble noble metals (TRUEX raffinate). Separate immobilization of these metals has benefits other than allowing an increase in the glass waste loading. These materials are quite resistant to dissolution (corrosion) as evidenced by the fact that they survive the chemically aggressive conditions in the fuel dissolver. Remnants of {var_epsilon}-metal particles have survived in the geologically natural reactors found in Gabon, Africa, indicating that they have sufficient durability to survive for {approx} 2.5 billion years in a reducing geologic environment. Additionally, the {var_epsilon}-metal can be made without additives and incorporate sufficient foreign material (oxides) that are also present in the UDS. Although {var_epsilon}-metal is found in fuel and Gabon as small particles ({approx}10 {micro}m in diameter) and has survived intact, an ideal waste form is one in which the surface area is minimized. Therefore, the main effort in developing {var_epsilon}-metal as a waste form is to develop a process to consolidate the particles into a monolith. Individually, these metals have high melting points (2617 C for Mo to 1552 C for Pd) and the alloy is

  8. Reduction of protein adsorption on silica and polysulfone surfaces coated with complex coacervate core micelles with poly(vinyl alcohol) as a neutral brush forming block

    NARCIS (Netherlands)

    Brzozowska, A. M.; Zhang, Q.; de Keizer, A.; Norde, W.; Stuart, M. A. Cohen

    2010-01-01

    We have studied the formation and stability of complex coacervate core micelles (C3Ms) in solution, and the influence of C3M coatings on the adsorption of the proteins beta-lactoglobulin (beta-lac), bovine serum albumin (BSA). and lysozyme (Lsz) on silica and polysulfone surfaces. The C3M5 consist o

  9. Rheology as a tool for evaluation of melt processability of innovative dosage forms.

    Science.gov (United States)

    Aho, Johanna; Boetker, Johan P; Baldursdottir, Stefania; Rantanen, Jukka

    2015-10-30

    Future manufacturing of pharmaceuticals will involve innovative use of polymeric excipients. Hot melt extrusion (HME) is an already established manufacturing technique and several products based on HME are on the market. Additionally, processing based on, e.g., HME or three dimensional (3D) printing, will have an increasingly important role when designing products for flexible dosing, since dosage forms based on compacting of a given powder mixture do not enable manufacturing of optimal pharmaceutical products for personalized treatments. The melt processability of polymers and API-polymer mixtures is highly dependent on the rheological properties of these systems, and rheological measurements should be considered as a more central part of the material characterization tool box when selecting suitable candidates for melt processing by, e.g., HME or 3D printing. The polymer processing industry offers established platforms, methods, and models for rheological characterization, and they can often be readily applied in the field of pharmaceutical manufacturing. Thoroughly measured and calculated rheological parameters together with thermal and mechanical material data are needed for the process simulations which are also becoming increasingly important. The authors aim to give an overview to the basics of rheology and summarize examples of the studies where rheology has been utilized in setting up or evaluating extrusion processes. Furthermore, examples of different experimental set-ups available for rheological measurements are presented, discussing each of their typical application area, advantages and limitations. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi

    Directory of Open Access Journals (Sweden)

    João S. Silva

    1992-09-01

    Full Text Available Accidental transmission of Chagas' disease to man by blood transfusion is a serious problem in Latin-America. This paper describes the testing of several synthetic, semi-synthetic, and natural compounds for their activity against blood trypomastigotes in vitro at 4-C. The compounds embody several types of chemical structures: benzoquinone, naphthoquinone, anthracenequinone, phenanthrenequinone, imidazole, piperazine, quinoline, xanthene, and simple benzenic and naphthalenic derivates. Some of them are for the first time tested against Trypanosoma cruzi. The toxic effect these compounds on this parasite was done by two quite distinct sets of experiments. In one set, the compounds were added to infected blood as ethanolic solution. In this situation the most active one was a furan-1, 2-naphthoquinone, in the same range as gentian violet, a new fact to be considered in the assessment of structure-activity relationships in this class of compounds. In other set, we tentatively evaluated the biological activity of water insoluble compounds by adding them in a pure form without solvent into infected blood. In this way some appear to be very active and it was postulated that the effectiveness of such compounds must result from interactions between them and specific blood components.

  11. Evaluation of the Biocidal Efficacy of Different Forms of Silver Against Cupriavidus (formerly Wautersia) Species Bacteria

    Science.gov (United States)

    Gazda, Daniel B.; Schultz, John R.; Wong, Wing; Algate, Michelle T.; Bryant, Becky; Castro, Victoria A.

    2009-01-01

    Contingency Water Containers (CWCs) are used to store potable and technical water that is transferred to the International Space Station (ISS) from the Shuttle orbiter vehicles. When CWCs are filled, water from the orbiter galley is passed through an ion exchange/activated carbon cartridge that removes the residual iodine biocide used on Shuttle before silver biocide is added. Removal of iodine and addition of silver is necessary to inhibit microbial growth inside CWCs and maintain compatibility with the water systems in the Russian segment of ISS. As part of nominal water transfer activities, crewmembers collect samples from several CWCs for postflight analysis. Results from the analysis of water transfer samples collected during the docked phases of STS-118/13A.1 and STS-120/10A showed that several of the CWCs contained up to 10(exp 4) CFU/mL of bacteria despite the fact that the silver concentrations in the CWCs were within acceptable limits. The samples contained pure cultures of a single bacteria, a Cupriavidus (formerly Wautersia) species that has been shown to be resistant to metallic biocides. As part of the investigation into the cause and remediation of the bacterial contamination in these CWCs, ground studies were initiated to evaluate the resistance of the Cupriavidus species to the silver biocides used on ISS and to determine the minimum effective concentration for the different forms of silver present in the biocides. The initial findings from those experiments are discussed herein.

  12. In situ niosome forming maltodextrin proniosomes of candesartan cilexetil: In vitro and in vivo evaluations.

    Science.gov (United States)

    Yuksel, Nilufer; Bayindir, Zerrin Sezgin; Aksakal, Elif; Ozcelikay, A Tanju

    2016-01-01

    The aim of this study is to develop novel proniosomal tablets of candesartan cilexetil. Drug loaded proniosomes were prepared as dry powder by slurry method. The critical parameters of the production process were the type of the carrier (sorbitol, maltodextrin, and lactose), addition of charge inducers, rotation speed of the rotavapor and solvent evaporation temperature. The effects of these parameters on proniosome specifications such as the recovery, drug loading, drug release were investigated and also the influence on the particle size and surface charge of the niosomes derived by the hydration of proniosomes were evaluated. The mean particle size and drug loading of niosomes formed from the hydrated proniosomes were 204 ± 2 nm and 99.09 ± 0.04% respectively, with a negative charge -43.65 ± 0.54 mV. The proniosomes demonstrated good flowability, compressibility and consolidation properties both alone and together with the tableting agents (microcrystalline cellulose and cross-linked poly vinylpyrrolidone). The niosomes derived by the hydration of proniosomal tablets preserved their initial properties. Compatibly with the increased in vitro drug dissolution rate, the relative bioavailability of drug from proniosomal tablets increased 1.86-fold and 2.75-fold and higher candesartan plasma levels were achieved within shorter time compared to the pure drug.

  13. Preparation and evaluation of microcapsules using polymerized rosin as a novel wall forming material.

    Science.gov (United States)

    Fulzele, S V; Satturwar, P M; Kasliwal, R H; Dorle, A K

    2004-02-01

    Sustained release diclofenac sodium microcapsules were prepared using polymerized rosin as a novel wall-forming material by a solvent evaporation technique. A novel method developed in our laboratory with the potential for scale-up and production of polymerized rosin microcapsules is detailed. These microcapsules might have application for development of implant/depot systems, primarily due to a sustained/controlled release capability and potential biocompatibility of polymerized rosin. The effect of variables like solvent systems, stirring speed and temperature were previously optimized. The solution system of drug and polymerized rosin dissolved in iso-propyl alcohol and acetone is sprayed with the help of a 0.5 mm nozzle spray gun in liquid paraffin maintained at 60 degrees C in the stirring condition. Varying drug:polymer ratios, namely 1:1, 1:2, 2:1, 1:3 and 3:1, were employed for microcapsule preparation. The prepared microcapsules were evaluated for size, shape, drug content and in vitro drug release. The morphology of microcapsules was characterized by scanning electron microscopy. The microcapsules show sustained release curves at pH 7.4 phosphate buffer for up to 10 h. The data obtained from the dissolution profiles were compared in the light of different kinetics models and the regression coefficients were compared. The in vitro dissolution study confirmed the Higuchi-order release pattern. Particle size and release data analysis from five consecutive batches prepared in the laboratory indicated suitable reproducibility of the proposed solvent evaporation process.

  14. Evaluating the presence of Toxoplasma gondii in peripheral blood of patients with diverse forms of uveitis.

    Science.gov (United States)

    Belfort, Rubens N; Isenberg, Jordan; Fernandes, Bruno F; Di Cesare, Sebastian; Belfort, Rubens; Burnier, Miguel N

    2017-02-01

    The purpose of this study was to evaluate the presence of Toxoplasmosis gondii in samples of peripheral blood from patients with varying etiologies of uveitis. Whole blood from patients with different forms of uveitis was tested for the presence of T. gondii using real-time PCR targeting the well-characterized 529 bp fragment. Extracted DNA was both frozen. Thirty-one patients were included in the current study and grouped as follows: acute toxoplasmosis (n = 10); toxoplasmic retinal scars (n = 9); non-infectious etiologies of uveitis (n = 6); and IgG negative for toxoplasmosis (n = 6). In total, only two patients were shown to have circulating T. gondii in peripheral blood; both of these patients were IgG positive for toxoplasmosis, were receiving immunosuppressive therapy for autoimmune uveitis, and had no clinical features of toxoplasmosis. T. gondii was identified in peripheral blood of some immunosuppressed patients. No other patients, including those with acute toxoplasmosis, had circulating parasites in peripheral blood.

  15. Defining core issues in utilizing information technology to improve access: evaluation and research agenda.

    Science.gov (United States)

    Jackson, George L; Krein, Sarah L; Alverson, Dale C; Darkins, Adam W; Gunnar, William; Harada, Nancy D; Helfrich, Christian D; Houston, Thomas K; Klobucar, Thomas F; Nazi, Kim M; Poropatich, Ronald K; Ralston, James D; Bosworth, Hayden B

    2011-11-01

    The Department of Veterans Affairs (VA) has been at the vanguard of information technology (IT) and use of comprehensive electronic health records. Despite the widespread use of health IT in the VA, there are still a variety of key questions that need to be answered in order to maximize the utility of IT to improve patient access to quality services. This paper summarizes the potential of IT to enhance healthcare access, key gaps in current evidence linking IT and access, and methodologic challenges for related research. We also highlight four key issues to be addressed when implementing and evaluating the impact of IT interventions on improving access to quality care: 1) Understanding broader needs/perceptions of the Veteran population and their caregivers regarding use of IT to access healthcare services and related information. 2) Understanding individual provider/clinician needs/perceptions regarding use of IT for patient access to healthcare. 3) System/Organizational issues within the VA and other organizations related to the use of IT to improve access. 4) IT integration and information flow with non-VA entities. While the VA is used as an example, the issues are salient for healthcare systems that are beginning to take advantage of IT solutions.

  16. Evaluation of Suppression of Synthetic Paraffinic Kerosene (SPK) Fuel Fires with Aqueous Film Forming Foam (AFFF)

    Science.gov (United States)

    2009-12-01

    FIRES WITH AQUEOUS FILM FORMING FOAM ( AFFF ...performance of Aqueous Film-Forming Foam ( AFFF ) on synthetic fuel fires to aid Air Force firefighters’ response to an incident. Results show that AFFF can...hydrocarbons. Aqueous Film Forming Foam ( AFFF ) is used by Air Force fire departments to extinguish fuel spill fires involving jet fuel (JP-8), diesel,

  17. Evaluating Statistical Targets for Assembling Parallel Mixed-Format Test Forms

    Science.gov (United States)

    Debeer, Dries; Ali, Usama S.; van Rijn, Peter W.

    2017-01-01

    Test assembly is the process of selecting items from an item pool to form one or more new test forms. Often new test forms are constructed to be parallel with an existing (or an ideal) test. Within the context of item response theory, the test information function (TIF) or the test characteristic curve (TCC) are commonly used as statistical…

  18. Strategies for capacity building for health research in Bangladesh: Role of core funding and a common monitoring and evaluation framework.

    Science.gov (United States)

    Mahmood, Shakeel; Hort, Krishna; Ahmed, Shakil; Salam, Mohammed; Cravioto, Alejandro

    2011-07-28

    There is increasing interest in building the capacity of researchers in low and middle income countries (LMIC) to address their national priority health and health policy problems. However, the number and variety of partnerships and funding arrangements can create management problems for LMIC research institutes. This paper aims to identify problems faced by a health research institute in Bangladesh, describe two strategies developed to address these problems, and identify the results after three years of implementation. This paper uses a mixture of quantitative and qualitative data collected during independent annual reviews of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) between 2006 and 2010. Quantitative data includes the number of research activities according to strategic priority areas, revenues collected and expenditure. Qualitative data includes interviews of researchers and management of ICDDR,B, and of research users and key donors. Data in a Monitoring and Evaluation Framework (MEF) were assessed against agreed indicators. The key problems faced by ICDDR,B in 2006 were insufficient core funds to build research capacity and supporting infrastructure, and an inability to direct research funds towards the identified research priorities in its strategic plan. Two strategies were developed to address these problems: a group of donors agreed to provide unearmarked pooled core funding, and accept a single common report based on an agreed MEF. On review after three years, there had been significant increases in total revenue, and the ability to allocate greater amounts of money on capacity building and infrastructure. The MEF demonstrated progress against strategic objectives, and better alignment of research against strategic priorities. There had also been changes in the sense of ownership and collaboration between ICDDR,B's management and its core donors. The changes made to funding relationships supported and monitored by

  19. Strategies for capacity building for health research in Bangladesh: Role of core funding and a common monitoring and evaluation framework

    Directory of Open Access Journals (Sweden)

    Mahmood Shakeel

    2011-07-01

    Full Text Available Abstract Background There is increasing interest in building the capacity of researchers in low and middle income countries (LMIC to address their national priority health and health policy problems. However, the number and variety of partnerships and funding arrangements can create management problems for LMIC research institutes. This paper aims to identify problems faced by a health research institute in Bangladesh, describe two strategies developed to address these problems, and identify the results after three years of implementation. Methods This paper uses a mixture of quantitative and qualitative data collected during independent annual reviews of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B between 2006 and 2010. Quantitative data includes the number of research activities according to strategic priority areas, revenues collected and expenditure. Qualitative data includes interviews of researchers and management of ICDDR,B, and of research users and key donors. Data in a Monitoring and Evaluation Framework (MEF were assessed against agreed indicators. Results The key problems faced by ICDDR,B in 2006 were insufficient core funds to build research capacity and supporting infrastructure, and an inability to direct research funds towards the identified research priorities in its strategic plan. Two strategies were developed to address these problems: a group of donors agreed to provide unearmarked pooled core funding, and accept a single common report based on an agreed MEF. On review after three years, there had been significant increases in total revenue, and the ability to allocate greater amounts of money on capacity building and infrastructure. The MEF demonstrated progress against strategic objectives, and better alignment of research against strategic priorities. There had also been changes in the sense of ownership and collaboration between ICDDR,B's management and its core donors. Conclusions The

  20. Development of Core Heat Removal Objective Provision Trees for Sodium-Cooled Fast Reactor Defense-in-Depth Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Huichang; Kang, Bongsuk; Lee, Youngho [TUEV Rheinland Korea Ltd., Seoul (Korea, Republic of); Suh, Namduk [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2013-10-15

    Based on the definition of Defense-in-Depth levels and safety functions for KALIMER sodium-cooled fast reactor, suggested in the reference and, OPTs for level 1, 2, and 3 defense-in-depth and core heat removal safety function, were developed and suggested in this paper. The purpose of this OPT is first to assure the defensein-depth design during the licensing of Sodium-Cooled Fast Reactors (SFR), but it will also contribute in evaluating the completeness of regulatory requirements under development by Korea Institute of Nuclear Safety (KINS). The challenges and mechanisms and provisions were briefly explained in this paper. Comparing the mechanisms and provisions with the requirements will contribute in identifying the missing requirements. Since the design of PGSFR (Prototype Gen-IV SFR) is not mature yet, the OPT is developed for KALIMER design. Developed OPTs in this study can be used for the identification of potential design vulnerabilities. When detailed identification of provisions in terms of design features were achieved through the next step of this study, it can contribute to the establishment of defensein-depth evaluation frame for the regulatory reviews for the licensing process. At this moment, the identified provisions have both aspects as requirements and design features already adopted in KALIMER design. In the next stage of this study, derived provisions to be adopted will be compared with the actual design features and findings can be suggested as recommendations for the safety improvement.

  1. Evaluation of solid-state forms present in tablets by Raman spectroscopy.

    Science.gov (United States)

    Taylor, L S; Langkilde, F W

    2000-10-01

    In this study the potential of Fourier transform (FT)-Raman spectroscopy as a method to probe the solid-state form of active substances present in tablets and capsules is explored. Raman spectra were obtained from intact tablets and capsules containing enalapril maleate, prednisolone, form I and form II polymorphs of ranitidine, anhydrous and monohydrate theophylline, and warfarin sodium clathrate. Spectra were also collected from the corresponding drug substances. These studies show that it is possible to detect the active ingredients in the intact dosage form, even where the substance comprises tablet. Moreover, it is shown that, in some cases, Raman spectroscopy can also be used to investigate the solid-state form of a drug present in the dosage form and even to determine if a mixture of forms are present.

  2. Banded transformer cores

    Science.gov (United States)

    Mclyman, C. W. T. (Inventor)

    1974-01-01

    A banded transformer core formed by positioning a pair of mated, similar core halves on a supporting pedestal. The core halves are encircled with a strap, selectively applying tension whereby a compressive force is applied to the core edge for reducing the innate air gap. A dc magnetic field is employed in supporting the core halves during initial phases of the banding operation, while an ac magnetic field subsequently is employed for detecting dimension changes occurring in the air gaps as tension is applied to the strap.

  3. Performance evaluation of aprons according to lead equipment and form types

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ki Won; Choi, Sung Hyun; Kim, Ki Yeol; Lee, Ik Pyo; Hwang, Sun Gwang [Dept. of Radiology, Kyung Hee University Hostpital at Gangdong, Seoul (Korea, Republic of); Dong, Kyung Rae [Dept. of of Radiological Technology, Gwangju Health University, Gwangju (Korea, Republic of)

    2017-02-15

    The apron is one of the essential protectors to reduce the exposure dose of radiological technologists. This study is to provide a guideline for purchasing the aprons with excellent performance and to help reducing the exposure dose by measuring the shielding ration and uniformity of aprons according to lead equivalent and form types. The shielding ratio of aprons were measured by using radiation generator and dosimeter. Exposure conditions were 81 kVp, 25 mAs, source to image receptor distance (SID) 100 cm and field of view (FOV) 17{sup ×}17{sup .} Exposure areas for front type and around type aprons were divided into 9 areas and for 2 pieces type aprons were divided into 3 areas of top and 4 areas of skirt. The uniformity of aprons were measured by using fluoroscopy and Image J. The 4 regions of interest (ROI) were set into acquired images and measured uniformity by measuring the standard deviation of pixel intensity in ROIs. In continuous shielding ration measurement of aprons according to exposure area, there was not statistical significance (P>0.05). In ANOVA test of aprons, there was statistical significance (P<0.01). In the results of shielding ratio, although the aprons had equal lead equivalent, there were difference in shielding ratio from 83.59% to 98.15%. In the results of uniformity, the front type aprons with equal lead equivalent indicated the similar uniformity. However, the around type and 2 pieces type apron with equal lead equivalent indicated the different uniformity each other, from 1.8 to 22.2. If the performance evaluation in this study were conducted regularly before and after purchase the aprons, the exposure does to patients and radiological technologists could be reduced.

  4. Evaluation of Cryotechniques for Tem Observation of Sols - Application to Boehmite Sols Used in Catalysts Forming

    Directory of Open Access Journals (Sweden)

    Fauchadour D.

    1999-07-01

    Full Text Available The use of suspensions in the heterogeneous catalysis field being a big issue, it appears important to be able to control this step as much as possible. Size of the objects in the suspension, aggregation state, homogeneity or heterogeneity (all called texture or structure here are some important parameters which are sometimes difficult to evaluate with traditionalmethods such as X-ray scattering or rheology. The cryotechniques applied to transmission electron microscopy is then an interesting alternative. Three different methods of cryofixation have been tested on low solid content suspensions of boehmite commonly used during the dispersion step of alumina carrier forming. Two different cryoprotectants were tested as well. It is shown that liquid propane immersion cooling (PL and slam freezing (SF methods require the use of a cryoprotectant whereas high pressure technique (HP avoids ice crystal formation without any addition of cryoprotectant in the suspension. It is shown also that DMSO is efficient with PL and SF techniques only when added at a high concentration (50% to the suspension. Glycerol is preferred because water is vitrified since that 30% of glycerol is added. Comparisons of high pressure preparations with and without glycerol show very little differences of texture on the replica. Explanations of the origin of the small differences of density are tentatively given. More analyses are now under progress to clarify the role of glycerol. Cryomicroscopy is conclude to be a very good technique when the texture of a suspension must be studied for example in the elaboration or in the improvement of a peptisation or a colloid formation process.

  5. New Closed-Form Results on Ordered Statistics of Partial Sums of Gamma Random Variables and its Application to Performance Evaluation in the Presence of Nakagami Fading

    KAUST Repository

    Nam, Sung Sik

    2017-06-19

    Complex wireless transmission systems require multi-dimensional joint statistical techniques for performance evaluation. Here, we first present the exact closed-form results on order statistics of any arbitrary partial sums of Gamma random variables with the closedform results of core functions specialized for independent and identically distributed Nakagami-m fading channels based on a moment generating function-based unified analytical framework. These both exact closed-form results have never been published in the literature. In addition, as a feasible application example in which our new offered derived closed-form results can be applied is presented. In particular, we analyze the outage performance of the finger replacement schemes over Nakagami fading channels as an application of our method. Note that these analysis results are directly applicable to several applications, such as millimeter-wave communication systems in which an antenna diversity scheme operates using an finger replacement schemes-like combining scheme, and other fading scenarios. Note also that the statistical results can provide potential solutions for ordered statistics in any other research topics based on Gamma distributions or other advanced wireless communications research topics in the presence of Nakagami fading.

  6. EVALUATION OF THOR MINERALIZED WASTE FORMS FOR THE DOE ADVANCED REMEDIATION TECHNOLOGIES PHASE 2 PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, C.; Jantzen, C.

    2012-02-02

    , sulfates/sulfides, chlorides, fluorides, volatile radionuclides or other aqueous components. The FBSR technology can process these wastes into a crystalline ceramic (mineral) waste form. The mineral waste form that is produced by co-processing waste with kaolin clay in an FBSR process has been shown to be as durable as LAW glass. Monolithing of the granular FBSR product, which is one of the objectives of this current study, is being investigated to prevent dispersion during transport or burial/storage but is not necessary for performance. FBSR testing of a Hanford LAW simulant and a WTP-SW simulant at the pilot scale was performed by THOR Treatment Technologies, LLC at Hazen Research Inc. in April/May 2008. The Hanford LAW simulant was the Rassat 68 tank blend and the target concentrations for the LAW was increased by a factor of 10 for Sb, As, Ag, Cd, and Tl; 100 for Ba and Re (Tc surrogate); 1,000 for I; and 254,902 for Cs based on discussions with the DOE field office and the environmental regulators and an evaluation of the Hanford Tank Waste Envelopes A, B, and C. It was determined through the evaluation of the actual tank waste metals concentrations that some metal levels were not sufficient to achieve reliable detection in the off-gas sampling. Therefore, the identified metals concentrations were increased in the Rassat simulant processed by TTT at HRI to ensure detection and enable calculation of system removal efficiencies, product retention efficiencies, and mass balance closure without regard to potential results of those determinations or impacts on product durability response such as Toxicity Characteristic Leach Procedure (TCLP). A WTP-SW simulant based on melter off-gas analyses from Vitreous State Laboratory (VSL) was also tested at HRI in the 15-inch diameter Engineering Scale Test Demonstration (ESTD) dual reformer at HRI in 2008. The target concentrations for the Resource Conservation and Recovery Act (RCRA) metals were increased by 16X for Se, 29X for

  7. EVALUATION OF THOR MINERALIZED WASTE FORMS FOR THE DOE ADVANCED REMEDIATION TECHNOLOGIES PHASE 2 PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, C.; Jantzen, C.

    2012-02-02

    , sulfates/sulfides, chlorides, fluorides, volatile radionuclides or other aqueous components. The FBSR technology can process these wastes into a crystalline ceramic (mineral) waste form. The mineral waste form that is produced by co-processing waste with kaolin clay in an FBSR process has been shown to be as durable as LAW glass. Monolithing of the granular FBSR product, which is one of the objectives of this current study, is being investigated to prevent dispersion during transport or burial/storage but is not necessary for performance. FBSR testing of a Hanford LAW simulant and a WTP-SW simulant at the pilot scale was performed by THOR Treatment Technologies, LLC at Hazen Research Inc. in April/May 2008. The Hanford LAW simulant was the Rassat 68 tank blend and the target concentrations for the LAW was increased by a factor of 10 for Sb, As, Ag, Cd, and Tl; 100 for Ba and Re (Tc surrogate); 1,000 for I; and 254,902 for Cs based on discussions with the DOE field office and the environmental regulators and an evaluation of the Hanford Tank Waste Envelopes A, B, and C. It was determined through the evaluation of the actual tank waste metals concentrations that some metal levels were not sufficient to achieve reliable detection in the off-gas sampling. Therefore, the identified metals concentrations were increased in the Rassat simulant processed by TTT at HRI to ensure detection and enable calculation of system removal efficiencies, product retention efficiencies, and mass balance closure without regard to potential results of those determinations or impacts on product durability response such as Toxicity Characteristic Leach Procedure (TCLP). A WTP-SW simulant based on melter off-gas analyses from Vitreous State Laboratory (VSL) was also tested at HRI in the 15-inch diameter Engineering Scale Test Demonstration (ESTD) dual reformer at HRI in 2008. The target concentrations for the Resource Conservation and Recovery Act (RCRA) metals were increased by 16X for Se, 29X for

  8. Annotated corpus and the empirical evaluation of probability estimates of grammatical forms

    Directory of Open Access Journals (Sweden)

    Ševa Nada

    2003-01-01

    Full Text Available The aim of the present study is to demonstrate the usage of an annotated corpus in the field of experimental psycholinguistics. Specifically, we demonstrate how the manually annotated Corpus of Serbian Language (Kostić, Đ. 2001 can be used for probability estimates of grammatical forms, which allow the control of independent variables in psycholinguistic experiments. We address the issue of processing Serbian inflected forms within two subparadigms of feminine nouns. In regression analysis, almost all processing variability of inflected forms has been accounted for by the amount of information (i.e. bits carried by the presented forms. In spite of the fact that probability distributions of inflected forms for the two paradigms differ, it was shown that the best prediction of processing variability is obtained by the probabilities derived from the predominant subparadigm which encompasses about 80% of feminine nouns. The relevance of annotated corpora in experimental psycholinguistics is discussed more in detail .

  9. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in a...

  10. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in...

  11. A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679.

    Science.gov (United States)

    Gosset, James R; Beaumont, Kevin; Matsuura, Tomomi; Winchester, Wendy; Attkins, Neil; Glatt, Sophie; Lightbown, Ian; Ulrich, Kristina; Roberts, Sonia; Harris, Jolie; Mesic, Emir; van Steeg, Tamara; Hijdra, Diana; van der Graaf, Piet H

    2017-06-07

    PF-05105679 is a moderately potent TRPM8 blocker which has been evaluated for the treatment of cold pain sensitivity. The TRPM8 channel is responsible for the sensation of cold environmental temperatures and has been implicated in regulation of core body temperature. Consequently, blockade of TRPM8 has been suggested to result in lowering of core body temperature. As part of the progression to human studies, the effect of PF-05105679 on core body temperature has been investigated in animals. Safety pharmacology studies showed that PF-05105679 reduced core body temperature in a manner that was inversely related to body weight of the species tested (greater exposure to PF-05105679 was required to lower temperature by 1°C in higher species). Based on an allometric (body weight) relationship, it was hypothesized that PF-05105679 would not lower core body temperature in humans at exposures that could exhibit pharmacological effects on cold pain sensation. On administration to humans, PF-05105679 was indeed effective at reversing the cold pain sensation associated with the cold pressor test in the absence of effects on core body temperature. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Experimental Verification of the Chemical Sensitivity of Two-Site Double Core-Hole States Formed by an X-ray FEL

    CERN Document Server

    Salen, P; Schmidt, H T; Thomas, R D; Larsson, M; Feifel, R; Piancastelli, M N; Fang, L; Murphy, B; Osipov, T; Berrah, N; Kukk, E; Ueda, K; Bozek, J D; Bostedt, C; Wada, S; Richter, R; Feyer, V; Prince, K C

    2012-01-01

    We have performed X-ray two-photon photoelectron spectroscopy (XTPPS) using the Linac Coherent Light Source (LCLS) X-ray free-electron laser (FEL) in order to study double core-hole (DCH) states of CO2, N2O and N2. The experiment verifies the theory behind the chemical sensitivity of two-site (ts) DCH states by comparing a set of small molecules with respect to the energy shift of the tsDCH state and by extracting the relevant parameters from this shift.

  13. Are Entrepreneurial Intentions Self-Regulated? Self-Consciousness, Core Self-Evaluations and Entrepreneurial Intentions of Higher Education Students.

    Science.gov (United States)

    Auzoult, Laurent; Lheureux, Florent; Abdellaoui, Sid

    2016-06-20

    The main aim of this study is to demonstrate that private self-consciousness (SC) and core self-evaluations (CSEs) influence their formation, via the perceived feasibility and desirability of entrepreneurship or in interaction with it. Two hundred and sixteen students, from a university, an engineering college and a management school, participated in a survey questionnaire which measured these variables as well as controlled factors (e.g. entrepreneurship education, presence of entrepreneurs in their close social network). The results confirm that CSEs have a positive effect on feasibility and desirability (p < .001) which mediate their effect on intention (p < .007). They also show that private SC has a positive direct effect on intention (p < .001). Additionally, the positive interaction effects of desirability and feasibility and public SC and feasibility on intention are highlighted (p < .05). Unexpectedly, none of the hypothesized moderation effects of private SC were corroborated. The convergence of these results with prior research, the limitations of the study and practical implications are discussed.

  14. Preliminary evaluation of a 99mTc labeled hybrid nanoparticle bearing a cobalt ferrite core: in vivo biodistribution.

    Science.gov (United States)

    Psimadas, Dimitrios; Baldi, Giovanni; Ravagli, Costanza; Bouziotis, Penelope; Xanthopoulos, Stavros; Franchini, Mauro Comes; Georgoulias, Panagiotis; Loudos, George

    2012-08-01

    Magnetic nanoparticles have become important tools for imaging a wide range of diseases, improving drug delivery and applying hyperthermic treatment. Iron oxide based nanoparticles have been widely examined, unlike cobalt ferrite based ones. Herein, monodisperse and stable CoFe2O4 nanoparticles have been produced, coated and further stabilized using ethyl 12-(hydroxyamino)-12-oxododecanoate, poly(lactic-co-glycolic acid) and bovine serum albumin. The final product, NBRh1, was fully characterized and has been directly radiolabeled with 99mTc using SnCl1 as the reducing agent in high yields. In vitro stability and hyperthermic properties of 99mTC-NBRh1 were encouraging for further application in low frequencies hyperthermia and biomagnetic applications. In vivo evaluation followed after injection in healthy mice. The planar and SPECT imaging data as well as the biodistribution results were in accordance, showing high liver and spleen uptake as expected starting almost immediately after administration. In conclusion the preliminary results for nanoparticles bearing a cobalt ferrite core justify further investigations towards potential hyperthermic applications, drug transportation and liver or spleen imaging.

  15. EUS-guided 22-gauge fine-needle aspiration versus core biopsy needle in the evaluation of solid pancreatic neoplasms.

    Science.gov (United States)

    Strand, Daniel S; Jeffus, Susanne K; Sauer, Bryan G; Wang, Andrew Y; Stelow, Edward B; Shami, Vanessa M

    2014-09-01

    Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is widely used for diagnosis of pancreatic lesions. The Echotip Procore Needle (Wilson-Cook Medical) is a new 22G fine biopsy needle (FNB) for obtaining core biopsy material at time of EUS. This study aimed to compare the technical and diagnostic performance of conventional FNA and FNB. Thirty-two patients met the design criteria for this prospective paired cohort study. All lesions sampled were solid (non-cystic) pancreatic masses by EUS appearance. Patients were randomized to receive FNA or FNB by first attempt. A cytopathologist performed on-site evaluations. Samples were assessed for accuracy of diagnosis, cellularity, contamination, and sufficiency for ancillary studies. Technical and diagnostic performances were compared. Compared to FNA, there was a statistically significant decreased ability of FNB to achieve a diagnosis (FNA 93.8%, FNB 28.1%, P needle. Regarding operator perceived ease-of-use, FNA outperformed FNB (P biopsy needle was not apparent in our series. Additional studies are needed before routine adoption of 22G FNB can be recommended. Copyright © 2014 Wiley Periodicals, Inc.

  16. Beyond packing of hard spheres: The effects of core softness, non-additivity, intermediate-range repulsion, and many-body interactions on the glass-forming ability of bulk metallic glasses

    Science.gov (United States)

    Zhang, Kai; Fan, Meng; Liu, Yanhui; Schroers, Jan; Shattuck, Mark D.; O'Hern, Corey S.

    2015-11-01

    When a liquid is cooled well below its melting temperature at a rate that exceeds the critical cooling rate Rc, the crystalline state is bypassed and a metastable, amorphous glassy state forms instead. Rc (or the corresponding critical casting thickness dc) characterizes the glass-forming ability (GFA) of each material. While silica is an excellent glass-former with small Rc alloys are typically poor glass-formers with large Rc > 1010 K/s. Only in the past thirty years have bulk metallic glasses (BMGs) been identified with Rc approaching that for silica. Recent simulations have shown that simple, hard-sphere models are able to identify the atomic size ratio and number fraction regime where BMGs exist with critical cooling rates more than 13 orders of magnitude smaller than those for pure metals. However, there are a number of other features of interatomic potentials beyond hard-core interactions. How do these other features affect the glass-forming ability of BMGs? In this manuscript, we perform molecular dynamics simulations to determine how variations in the softness and non-additivity of the repulsive core and form of the interatomic pair potential at intermediate distances affect the GFA of binary alloys. These variations in the interatomic pair potential allow us to introduce geometric frustration and change the crystal phases that compete with glass formation. We also investigate the effect of tuning the strength of the many-body interactions from zero to the full embedded atom model on the GFA for pure metals. We then employ the full embedded atom model for binary BMGs and show that hard-core interactions play the dominant role in setting the GFA of alloys, while other features of the interatomic potential only change the GFA by one to two orders of magnitude. Despite their perturbative effect, understanding the detailed form of the intermetallic potential is important for designing BMGs with cm or greater casting thickness.

  17. Effects of person-vocation fit and core self-evaluation on career commitment of medical university students: the mediator roles of anxiety and career satisfaction

    Science.gov (United States)

    2014-01-01

    Background How the career commitment of medical university students can be improved is an underinvestigated topic. Aim This experimental study aims to explore the factors that influence career commitment of medical university students. Methods One hundred eighty-two medical university students completed the vocational value questionnaire, state anxiety scale, core self-evaluation scale, Minnesota satisfaction questionnaire, and the Chinese career commitment questionnaire. Results (1) A mismatch was found between the vocational value and the medical career of medical university students, primarily in their self-development; (2) Core self-evaluation can significantly predict the continued commitment of medical university students; (3) Vocational value, career fit, and core self-evaluation can significantly predict the affective commitment and normative commitment of medical university students, while state anxiety and vocational satisfaction play significant mediating roles. Conclusions Both person–vocation fit and core self-evaluation can affect the career commitment of medical university students, while job satisfaction and state anxiety play mediating roles. PMID:24555701

  18. The Relationship between Core Self-Evaluations and Work and Family Satisfaction: The Mediating Role of Work-Family Conflict and Facilitation

    Science.gov (United States)

    Boyar, Scott L.; Mosley, Donald C., Jr.

    2007-01-01

    This study examines the impact of work-family conflict and work-family facilitation on work and family outcomes and explores the influence of core self-evaluations (CSE) among these relationships. CSE is comprised of self-esteem, neuroticism, locus of control, and general self-efficacy. CSE was found to be negatively related to work interfering…

  19. Evaluation of a Core Team Centred Professional Development Programme for Building a Whole-School Cooperative Problem Solving Approach to Conflict

    Science.gov (United States)

    White, Andrew Jonathan; Wertheim, Eleanor H.; Freeman, Elizabeth; Trinder, Margot

    2013-01-01

    This study evaluated a professional learning approach using a core team (CT) model to assist primary (elementary) schools to develop whole-school collaborative conflict resolution processes. Thirteen schools were matched and randomly assigned to the enhancing relationships in school communities programme ("n"?=?10) or a non-programme control group…

  20. Mediation Effect of Research Skills Proficiency on the Core Self-Evaluations--Research Engagement Relationship among Master of Education Students in Uganda

    Science.gov (United States)

    Atibuni, Dennis Zami; Olema, David Kani; Ssenyonga, Joseph; Karl, Steffens; Kibanja, Grace Milly

    2017-01-01

    This study investigated the mediation effect of research skills proficiency on the relationship between core self-evaluations and research engagement among Master of Education students in Uganda. Questionnaire surveys including closed ended questions were administered to two cohorts of the students, 2011/2012 and 2012/2013, (N = 102). Results…

  1. [Preparation and evaluation of press-coated aminophylline tablet using crystalline cellulose and polyethylene glycol in the outer shell for timed-release dosage forms].

    Science.gov (United States)

    Watanabe, Yoshiteru; Mukai, Baku; Kawamura, Ken-ichi; Ishikawa, Tatsuya; Namiki, Michihiro; Utoguchi, Naoki; Fujii, Makiko

    2002-02-01

    In an attempt to achieve chronopharmacotherapy for asthma, press-coated tablets (250 mg), which contained aminophylline in the core tablet in the form of low-substituted hydroxypropylcellulose (L-HPC) and coated with crystalline cellulose (PH-102) and polyethylene glycol (PEG) at various molecular weights and mixing ratios in the amounts of PH-102 and PEG as the outer shell (press-coating material), were prepared (chronopharmaceutics). Their applicability as timed-release (delayed-release) tablets with a lag time of disintegration and a subsequent rapid drug release phase was investigated. Various types of press-coated tablets were prepared using a tableting machine, and their aminophylline dissolution profiles were evaluated by the JP paddle method. Tablets with the timed-release characteristics could be prepared, and the lag time of disintegration was prolonged as the molecular weight and the amount of PEG, for example PEG 500,000, in the outer shell were increased. The lag time of disintegration could be controlled by the above-mentioned method, however, the pH of the medium had no effect on disintegration of the tablet and dissolution behavior of theophylline. The press-coated tablet (core tablet:aminophylline 50 mg, L-HPC and PEG 6000; outer shell:PH-102:PEG = 8:2 200 mg) with the timed-release characteristics was administered orally to rabbits for an in vivo test. Theophylline was first detected in plasma more than 2 h after administration; thus, this tablet showed a timed-release characteristics in the gastrointestinal tract. The time (tmax) required to reach the maximum plasma theophylline concentration (Cmax) observed after administration of the press-coated tablet was significantly (p 24) between the press-coated tablet and aminophylline solution. These results suggest that the press-coated aminophylline tablet (with the timed-release characteristic) offers a promising forms of theophylline chronotherapy for asthma.

  2. Residual stress evaluation and curvature behavior of aluminum 7050 peen forming processed; Avaliacao da tensao residual em aluminio 7050 conformado pelo processo peen forming

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Rene Ramos de

    2011-07-01

    Shot peening is a superficial cold work process used to increase the fatigue life evaluated by residual stress measurements. The peen forming process is a variant of the shot peening process, where a curvature in the plate is obtained by the compression of the grains near to the surface. In this paper, the influence of the parameters such as: pressure of shot, ball shot size and thickness of aluminum 7050 samples with respect to residual stress profile and resulting arc height was studied. The evaluation of the residual stress profile was obtained by sin{sup 2} {psi} method. The results show that the formation of the curvature arc height is proportional to the shot peening pressure, of spheres size and inversely proportional to the thickness of the sample, and that stress concentration factor is larger for samples shot peened with small balls. On final of this paper presents an additional study on micro strain and average crystallite size, which can evaluate the profile of the samples after blasting. (author)

  3. Multi-compartmental transdermal patch for simultaneous delivery of multiple drugs: formulation and evaluation of newly developed novel dosage form

    Directory of Open Access Journals (Sweden)

    Vijayan Venugopal

    2015-07-01

    Full Text Available Objective: To evaluate the formulation of multi-compartmental transdermal patches for simultaneous delivery of multiple drugs: aceclofenac and serratiopeptidase. Methods: The patch was prepared by simple solvent casting method using hydroxy propyl methyl cellulose K100M as matrix forming agent and dimethyl sulphoxide as permeation enhancer. The prepared transdermal patch was evaluated by physiochemical parameters and in- vitro diffusion studies. Results: The multi-compartmental transdermal patch showed sustained drug release over the period of 12 h. Conclusions: Multicompartmental transdermal patches shows better bioavailability, therapeutic efficacy and very economic as compared with other dosage forms.

  4. Forming of the regional core transport network taking into account the allocation of alternative energy sources based on artificial intelligence methods

    Directory of Open Access Journals (Sweden)

    Marina ZHURAVSKAYA

    2014-12-01

    Full Text Available In the modern world the alternative energy sources, which considerably depend on a region, play more and more significant role. However, the transition of regions to new energy sources lead to the change of transport and logistic network configuration. The formation of optimal core transport network today is a guarantee of the successful economic development of a region tomorrow. The present article studies the issue of advanced core transport network development in a region based on the experience of European and Asian countries and the opportunity to adapt the best foreign experience to Russian conditions. On the basis of artificial intelligence methods for forest industry complex of Sverdlovskaya Oblast the algorithm of problem solution of an optimal logistic infrastructure allocation is offered and some results of a regional transport network are presented. These methods allowed to solve the set task in the conditions of information uncertainty. There are suggestions on the improvement of transport and logistic network in the territory of Sverdlovskaya Oblast. Traditionally the logistics of mineral fuel plays main role in regions development. Actually it is required to develop logistic strategic plans to be able to provide different possibilities of power-supply, flexible enough to change with the population density, transport infrastructure and demographics of different regions. The problem of logistic centers allocation was studied by many authors. The approach, offered by the authors of this paper is to solve the set of tasks by applying artificial intelligence methods, such as fuzzy set theory and genetic algorithms.

  5. Evaluating the flux of extraterrestrial osmium at the onset of Younger Dryas in the GRIP ice core

    Science.gov (United States)

    Seo, J. H.; Han, C.; Hong, S.; Steffensen, J. P.; Sharma, M.

    2016-12-01

    The Younger Dryas (YD: 12.9-11.6 ka) was an abrupt cooling event during the last deglaciation. The mechanism behind the cooling is suggested to be a temporary slowdown of North Atlantic thermohaline circulation due to catastrophic release of meltwater from proglacial Lake Agassiz during the retreat of the Laurentide Ice Sheet [1]. An alternative hypothesis states that the cooling was directly/indirectly triggered by one or more cosmic airbursts/impacts [2]. While several papers have documented evidence for a YD extraterrestrial impact including microspherules, nanodiamonds, magnetic grains, and glass-like carbon [4-7], this hypothesis remains controversial [8-10]. In a recent study by Petaev et al. [11], an unusually high Pt/Ir ratio of 1200 was discovered in the GISP-2 ice core at the onset of YD, indicating a large Pt enriched iron meteorite impact. Such a high Pt/Ir in extraterrestrial materials has not been documented [12]. Thus, Petaev et al. [11] acknowledge that the interpretation of the Pt anomaly is based on circumstantial evidence. The distinct Os isotopic composition (187Os/188Os ratio) of the terrestrial (=1.26) and extraterrestrial (= 0.13) sources should allow us to evaluate if there was a meteorite impact at the YD boundary. These analyses are technically challenging owing to rather low concentration of Os in ice-melts ( 1x10-15g/g). Here, we will present Os isotope data from the GRIP ice core spanning the time period through YD to shed light on the meteorite/comet impact hypothesis. [1] Broecker et al. (1989) Nature 341, 318-321; [2] Firestone et al. (2007) PNAS. 104, 16016-16021; [3] Bunch et al. (2012) PNAS. 109, 1903-1912; [4] LeCompte et al. (2012) PNAS. 109, 2960-2969; [5] Wittke et al. (2013) PNAS 110, 2088-2097; [6] Wu et al. (2013) PNAS. 110, 3557-3566; [7] Kennett et al. (2015) PNAS 112, E4344-E4353; [8] Pinter et al. (2011) Earth Sci. Rev., 106, 247-264; [9] Holliday et al. (2014) J. Quat. Sci. 29, 515-530; [10] Meltzer et al. (2014) PNAS

  6. Colorado cultural resource survey: cultural resource re-evaluation form [5JA784

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document includes the survey forms necessary to assess cultural resources in Colorado. This document assesses the Allard ranch (5JA784) on Arapaho National...

  7. A study on characterization and evaluation methodologies of radioactive waste forms for safe disposal

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Y. C.; Lee, G. S.; Kim, G. J.; Nam, H.; Seok, J. H. [Yonsei Univ., Seoul (Korea, Republic of)

    2004-02-15

    The contents and scope of the study are summarized as follows : elicitation of significant items for characteristic assessment about stability analysis of radioactive waste forms for safe disposal, compressive strength, free water, leaching rate, and weatherability. Suggestion of assessment methods through the characteristic test of waste forms, comparison of assessment methods and suggestion of suitable testing methods about the above stated 4 items. Assessment modeling development for long-term stability of radioactive waste forms, weatherometric test of waste forms, expectation modeling development through VOM(Valance-Oxygen Model). Suggestion of determination standard together assessment testing methods and description about the standard. Explanation to be suitable guideline and regulation of waste handling and acceptance.

  8. Evaluation of Vitreous and Devitrifying Enamels as Hot Forming Lubricants for Aluminum AA5083 Alloy

    Science.gov (United States)

    Riahi, A. R.; Morales, A. T.; Alpas, A. T.

    2008-06-01

    The adhesion of aluminum to tool surfaces during the hot forming of sheet aluminum alloys presents challenging tribological problems. Graphite and boron nitride are commonly used as aluminum adhesion mitigating solid lubricants for hot forming processes, but lubricant breakdown in high-stress areas, such as corners and bends, remains an issue compromising the quality of the formed parts as well as the tool life. Low-melting temperature enamels may provide an affordable and easy to apply alternative. In this study, vitreous (amorphous glass) and devitrifying (two phase crystalline glass) layers were deposited on the surface of sheet aluminum samples with a sedimentation technique. Enamel lubrication was effective in preventing aluminum transfer to the steel counterface. Hence, the prospect exists for the use of these enamels as aluminum workpiece lubricants in hot forming operations.

  9. Colorado cultural resource survey: cultural resource re-evaluation form [5JA783

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document includes the survey forms necessary to assess cultural resources in Colorado. This document assesses the Case ranch (5JA783) on Arapaho National...

  10. Rapid on-site evaluation of endoscopic ultrasound core biopsy specimens has excellent specificity and positive predictive value for gastrointestinal lesions.

    Science.gov (United States)

    Krishnan, Kumar; Dalal, Sharvari; Nayar, Ritu; Keswani, Rajesh N; Keefer, Laurie; Komanduri, Srinadh

    2013-07-01

    Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) is a safe and effective way to sample lesions in the gastrointestinal tract. Rapid on-site specimen evaluation (ROSE) improves the accuracy of EUS-FNA. While data suggests that EUS with fine-needle biopsy (EUS-FNB) is effective, it remains unclear if ROSE is predictive of a final diagnosis when obtaining core specimens. The aim of this study was to investigate the utility of ROSE in achieving a final diagnosis for EUS-FNB core specimens. We evaluated 60 consecutive patients referred for EUS guided sampling of lesions within or adjacent to the gastrointestinal tract. All patients underwent EUS-FNB to evaluate the additive value of ROSE to the diagnostic accuracy of specimens obtained using a core biopsy needle. EUS-FNA was also performed in a majority of cases. EUS-FNB was feasible in all 60 cases; on-site specimen adequacy and final diagnostic accuracy was 58 % [95 % confidence intervals (CI) 45.1-71.2] and 83 % (95 % CI 71.9-91.5), respectively. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value of ROSE for core biopsies were 65, 100, 100, and 39 %, respectively. On-site adequacy and diagnostic accuracy for EUS-FNA was 38 % (95 % CI 22.2-53.5) and 63 % (95 % CI 50.1-75.8), respectively. There were no significant complications. EUS-FNB is safe, feasible, and effective. ROSE of the core biopsy provides excellent PPV; however, an inadequate ROSE appears to be of limited value. Further prospective studies are needed to assess the optimal handling and onsite processing of core specimens to determine whether ROSE is beneficial for EUS-FNB.

  11. Making an Ice Core.

    Science.gov (United States)

    Kopaska-Merkel, David C.

    1995-01-01

    Explains an activity in which students construct a simulated ice core. Materials required include only a freezer, food coloring, a bottle, and water. This hands-on exercise demonstrates how a glacier is formed, how ice cores are studied, and the nature of precision and accuracy in measurement. Suitable for grades three through eight. (Author/PVD)

  12. A Comparative Evaluation of Effect of Different Chemical Solvents on the Shear Bond Strength of Glass Fiber reinforced Post to Core Material.

    Science.gov (United States)

    Sharma, Ashish; Samadi, Firoza; Jaiswal, Jn; Saha, Sonali

    2014-01-01

    To compare the effect of different chemical solvents on glass fiber reinforced posts and to study the effect of these solvents on the shear bond strength of glass fiber reinforced post to core material. This study was conducted to evaluate the effect of three chemical solvents, i.e. silane coupling agent, 6% H2O2 and 37% phosphoric acid on the shear bond strength of glass fiber post to a composite resin restorative material. The changes in post surface characteristics after different treatments were also observed, using scanning electron microscopy (SEM) and shear bond strength was analyzed using universal testing machine (UTM). Surface treatment with hydrogen peroxide had greatest impact on the post surface followed by 37% phosphoric acid and silane. On evaluation of the shear bond strength, 6% H2O2 exhibited the maximum shear bond strength followed in descending order by 37% phosphoric acid and silane respectively. The surface treatment of glass fiber post enhances the adhesion between the post and composite resin which is used as core material. Failure of a fiber post and composite resin core often occurs at the junction between the two materials. This failure process requires better characterization. How to cite this article: Sharma A, Samadi F, Jaiswal JN, Saha S. A Comparative Evaluation of Effect of Different Chemical Solvents on the Shear Bond Strength of Glass Fiber Reinforced Post to Core Material. Int J Clin Pediatr Dent 2014;7(3):192-196.

  13. What is the use? Application of the short form (SF) questionnaires for the evaluation of treatment effects

    NARCIS (Netherlands)

    Pelle, Aline J.; Kupper, Nina; Mols, Floortje; de Jonge, Peter

    Health status has evolved as a clinical outcome measure that is of great interest in medical care. However, there is still debate about the appropriateness of scoring algorithms for the often used short form questionnaires. Therefore, our aim was to evaluate the consequences of the traditional

  14. The Use of Qualitative Forms of Evaluation for Improving Educational Practice.

    Science.gov (United States)

    Eisner, Elliot W.

    1979-01-01

    Non-quantifiable knowledge, involving sensory information, conceptualization, and imagination, is discussed in relation to educational evalution. Evaluation is discussed in terms of educational connoisseurship, or the art of appreciation; and educational criticism, which informs, interprets, and appraises. (MH)

  15. Fabrication and Evaluation of Graphite Fiber-Reinforced Polyimide Composite Tube Forms Using Modified Resin Transfer Molding

    Science.gov (United States)

    Exum, Daniel B.; Ilias, S.; Avva, V. S.; Sadler, Bob

    1997-01-01

    The techniques necessary for the fabrication of a complex three-dimensional tubular form using a PMR-type resin have been developed to allow for the construction of several tubes with good physical and mechanical properties. Employing established resin transfer molding practices, the relatively non-hazardous AMB-21 in acetone formulation was used to successfully impregnate four layers of AS4 braided graphite fiber preform previously loaded around an aluminum cylindrical core in an enclosed mold cavity. Using heat and vacuum, the solvent was evaporated to form a prepreg followed by a partial imidization and removal of condensation products. The aluminum core was replaced by a silicone rubber bladder and the cure cycle continued to the final stage of 550 F with a bladder internal pressure of 200 lbs/sq in while simultaneously applying a strong vacuum to the prepreg for removal of any additional imidization products. A combination of several modifications to the standard resin transfer molding methodology enabled the mold to 'breathe', allowing the imidization products a pathway for escape. AMB-21 resin was chosen because of the carcinogenic nature of the primary commercial polyimide PMR-15. The AMB-21 resin was formulated using commercially available monomers or monomer precursors and dissolved in a mixture of methyl alcohol and acetone. The viscosity of the resulting monomer solution was checked by use of a Brookfield rheometer and adjusted by adding acetone to an easily pumpable viscosity of about 600 cP. In addition, several types of chromatographic and thermal analyses were of the braids, and excess handling of the preforms broke some of the microscopic fibers, needlessly decreasing the strength of the finished part. In addition, three dimensional braided preforms with fibers along the length of the tube will be significantly stronger in tension than the braided preforms used in this study.

  16. The curvilinear relationship between work pressure and momentary task performance: The role of state and trait Core Self-Evaluations

    Directory of Open Access Journals (Sweden)

    Joeri eHofmans

    2015-10-01

    Full Text Available Whereas several studies have demonstrated that Core Self-Evaluations (CSE–or one’s appraisals about one’s own self-worth, capabilities, and competences–relate to job outcomes, less is known about the mechanisms underlying these relationships. In the present study, we address this issue by examining the role of within- and between-person variation in CSE in the relationship between work pressure and task performance. We hypothesized that (a work pressure relates to task performance in a curvilinear way, (b state CSE mediates the curvilinear relationship between work pressure and task performance, and (c the relationship between work pressure and state CSE is moderated by trait CSE. Our hypotheses were tested via a ten-day daily diary study with 55 employees in which trait CSE was measured at baseline, while work pressure, task performance, and state CSE were assessed on a daily basis. Bayesian multilevel path analysis showed that work pressure affects task performance via state CSE, with state CSE increasing as long as the employee feels that (she is able to handle the work pressure, while it decreases when the level of work pressure exceeds the employees’ coping abilities. Moreover, we found that for people low on trait CSE, the depleting effect of work pressure via state CSE happens for low levels of work pressure, while for people high in trait CSE the depleting effect is located at high levels of work pressure. Together, our findings suggest that the impact of work pressure on task performance is driven by a complex interplay of between- and within-person differences in CSE.

  17. The curvilinear relationship between work pressure and momentary task performance: the role of state and trait core self-evaluations.

    Science.gov (United States)

    Hofmans, Joeri; Debusscher, Jonas; Dóci, Edina; Spanouli, Andromachi; De Fruyt, Filip

    2015-01-01

    Whereas several studies have demonstrated that core self-evaluations (CSE)-or one's appraisals about one's own self-worth, capabilities, and competences-relate to job outcomes, less is known about the mechanisms underlying these relationships. In the present study, we address this issue by examining the role of within- and between-person variation in CSE in the relationship between work pressure and task performance. We hypothesized that (a) work pressure relates to task performance in a curvilinear way, (b) state CSE mediates the curvilinear relationship between work pressure and task performance, and (c) the relationship between work pressure and state CSE is moderated by trait CSE. Our hypotheses were tested via a 10-day daily diary study with 55 employees in which trait CSE was measured at baseline, while work pressure, task performance, and state CSE were assessed on a daily basis. Bayesian multilevel path analysis showed that work pressure affects task performance via state CSE, with state CSE increasing as long as the employee feels that (s)he is able to handle the work pressure, while it decreases when the level of work pressure exceeds the employees' coping abilities. Moreover, we found that for people low on trait CSE, the depleting effect of work pressure via state CSE happens for low levels of work pressure, while for people high in trait CSE the depleting effect is located at high levels of work pressure. Together, our findings suggest that the impact of work pressure on task performance is driven by a complex interplay of between- and within-person differences in CSE.

  18. Student Evaluation of Teaching: A Study Exploring Student Rating Instrument Free-Form Text Comments

    Science.gov (United States)

    Stupans, Ieva; McGuren, Therese; Babey, Anna Marie

    2016-01-01

    Student rating instruments are recognised to be valid indicators of effective instruction, providing a valuable tool to improve teaching. However, free-form text comments obtained from the open-ended question component of such surveys are only infrequently analysed comprehensively. We employed an innovative, systematic approach to the analysis of…

  19. Development of a Rating Form to Evaluate Grant Applications to the Hogg Foundation for Mental Health

    Science.gov (United States)

    Whaley, Arthur L.; Rodriguez, Reymundo; Alexander, Laurel A.

    2006-01-01

    Reliance on subjective grant proposal review methods leads private philanthropies to underfund mental health programs, even when foundations have mental health focuses. This article describes a private mental health foundation's efforts to increase the objectivity of its proposal review process by developing a reliable, valid proposal rating form.…

  20. Test plan for formulation and evaluation of grouted waste forms with shine process wastes

    Energy Technology Data Exchange (ETDEWEB)

    Ebert, W. L. [Argonne National Lab. (ANL), Argonne, IL (United States); Jerden, J. L. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-01

    The objective of this experimental project is to demonstrate that waste streams generated during the production of Mo99 by the SHINE Medical Technologies (SHINE) process can be immobilized in cement-based grouted waste forms having physical, chemical, and radiological stabilities that meet regulatory requirements for handling, storage, transport, and disposal.

  1. Environmental correlates of cycling: Evaluating urban form and location effects based on Danish micro-data

    DEFF Research Database (Denmark)

    Nielsen, Thomas Alexander Sick; Olafsson, Anton Stahl; Carstensen, Trine Agervig

    2013-01-01

    The paper analyses the environmental correlates of cycling based on Danish transportation and urban form micro-data. The results show that established walkability factors such as density, connectivity and diversity are related to cycling, but access to retail concentrations/centres, public...

  2. Analysis of resin-dentin interface morphology and bond strength evaluation of core materials for one stage post-endodontic restorations.

    Science.gov (United States)

    Bitter, Kerstin; Gläser, Christin; Neumann, Konrad; Blunck, Uwe; Frankenberger, Roland

    2014-01-01

    Restoration of endodontically treated teeth using fiber posts in a one-stage procedure gains more popularity and aims to create a secondary monoblock. Data of detailed analyses of so called "post-and-core-systems" with respect to morphological characteristics of the resin-dentin interface in combination with bond strength measurements of fiber posts luted with these materials are scarce. The present study aimed to analyze four different post-and-core-systems with two different adhesive approaches (self-etch and etch-and-rinse). Human anterior teeth (n = 80) were endodontically treated and post space preparations and post placement were performed using the following systems: Rebilda Post/Rebilda DC/Futurabond DC (Voco) (RB), Luxapost/Luxacore Z/Luxabond Prebond and Luxabond A+B (DMG) (LC), X Post/Core X Flow/XP Bond and Self Cure Activator (Dentsply DeTrey) (CX), FRC Postec/MultiCore Flow/AdheSE DC (Ivoclar Vivadent) (MC). Adhesive systems and core materials of 10 specimens per group were labeled using fluorescent dyes and resin-dentin interfaces were analyzed using Confocal Laser Scanning Microscopy (CLSM). Bond strengths were evaluated using a push-out test. Data were analyzed using repeated measurement ANOVA and following post-hoc test. CLSM analyses revealed significant differences between groups with respect to the factors hybrid layer thickness (pstrength was significantly affected by core material (p = 0.001), location inside the root canal (pstrength compared to LC [14.2 (8.7) MPa] and RB [13.3 (3.7) MPa] (pstrengths inside the root canal were not affected by the adhesive approach of the post-and-core-system. All systems demonstrated homogenous hybrid layer formation and penetration into the dentinal tubules in spite of the complicating conditions for adhesion inside the root canal.

  3. Development and evaluation of a prediction model for underestimated invasive breast cancer in women with ductal carcinoma in situ at stereotactic large core needle biopsy.

    Directory of Open Access Journals (Sweden)

    Suzanne C E Diepstraten

    Full Text Available BACKGROUND: We aimed to develop a multivariable model for prediction of underestimated invasiveness in women with ductal carcinoma in situ at stereotactic large core needle biopsy, that can be used to select patients for sentinel node biopsy at primary surgery. METHODS: From the literature, we selected potential preoperative predictors of underestimated invasive breast cancer. Data of patients with nonpalpable breast lesions who were diagnosed with ductal carcinoma in situ at stereotactic large core needle biopsy, drawn from the prospective COBRA (Core Biopsy after RAdiological localization and COBRA2000 cohort studies, were used to fit the multivariable model and assess its overall performance, discrimination, and calibration. RESULTS: 348 women with large core needle biopsy-proven ductal carcinoma in situ were available for analysis. In 100 (28.7% patients invasive carcinoma was found at subsequent surgery. Nine predictors were included in the model. In the multivariable analysis, the predictors with the strongest association were lesion size (OR 1.12 per cm, 95% CI 0.98-1.28, number of cores retrieved at biopsy (OR per core 0.87, 95% CI 0.75-1.01, presence of lobular cancerization (OR 5.29, 95% CI 1.25-26.77, and microinvasion (OR 3.75, 95% CI 1.42-9.87. The overall performance of the multivariable model was poor with an explained variation of 9% (Nagelkerke's R(2, mediocre discrimination with area under the receiver operating characteristic curve of 0.66 (95% confidence interval 0.58-0.73, and fairly good calibration. CONCLUSION: The evaluation of our multivariable prediction model in a large, clinically representative study population proves that routine clinical and pathological variables are not suitable to select patients with large core needle biopsy-proven ductal carcinoma in situ for sentinel node biopsy during primary surgery.

  4. A novel gastro-floating multiparticulate system for dipyridamole (DIP) based on a porous and low-density matrix core: in vitro and in vivo evaluation.

    Science.gov (United States)

    Li, Zhao; Xu, Heming; Li, Shujuan; Li, Qijun; Zhang, Wenji; Ye, Tiantian; Yang, Xinggang; Pan, Weisan

    2014-01-30

    The study was aimed to develop a novel gastro-floating multiparticulate system based on a porous and low-density matrix core with excellent floatability. The gastro-floating pellets (GFP) were composed of a porous matrix core, a drug loaded layer (DIP and HPMC), a sub-coating layer (HPMC) and a retarding layer (Eudragit(®) NE 30D). The porous matrix cores were evaluated in specific. EC was chosen as the matrix membrane for its rigidity and minimal expansion to large extent. The porous matrix core was achieved by the complete release of the bulk water soluble excipient from the EC coated beads, and mannitol was selected as the optimal water soluble excipient. SEM photomicrographs confirmed the structure of porous matrix cores. The compositions of GFP were investigated and optimized by orthogonal array design. The optimized formulation could sustain the drug release for 12h and float on the dissolution medium for at least 12h without lag time to float. The pharmacokinetic study was conducted in beagle dogs, and the relative bioavailability of the test preparation was 193.11±3.43%. In conclusion, the novel gastro-floating pellets can be developed as a promising approach for the gastro-retentive drug delivery systems.

  5. A study to evaluate the efficacy of image-guided core biopsy in the diagnosis and management of lymphoma-Results in 103 biopsies

    Energy Technology Data Exchange (ETDEWEB)

    Vandervelde, C. [Department of Radiology, Eastbourne District General Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD (United Kingdom)], E-mail: clivevandervelde@gmail.com; Kamani, T. [Department of ENT Surgery, Eastbourne District General Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD (United Kingdom)], E-mail: tkamany@yahoo.com; Varghese, A. [Department of Radiology, Eastbourne District General Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD (United Kingdom)], E-mail: vargheseajay@hotmail.com; Ramesar, K. [Department of Histopathology, Eastbourne District General Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD (United Kingdom)], E-mail: keith.ramesar@esht.nhs.uk; Grace, R. [Department of Haematology, Eastbourne District General Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD (United Kingdom)], E-mail: richard.grace@esht.nhs.uk; Howlett, D.C. [Department of Radiology, Eastbourne District General Hospital, Kings Drive, Eastbourne, East Sussex BN21 2UD (United Kingdom)], E-mail: david.howlett@esht.nhs.uk

    2008-04-15

    The reason for this study was to evaluate the ability of image-guided core biopsy to replace surgical excision by providing sufficient diagnostic and treatment information. All consecutive image-guided core biopsies in patients with a final diagnosis of lymphoma over a 6-year period at our institution were collected retrospectively. Case notes and pathology reports were reviewed and the diagnostic techniques used were recorded. Pathology reports were graded according to their diagnostic completeness and their ability to provide treatment information. Out of a total of 328 instances of lymphoma, 103 image-guided core biopsies were performed in 96 patients. In 78% of these, the diagnostic information obtained from the biopsy provided a fully graded and subtyped diagnosis of lymphoma with sufficient information to initiate therapy. In the head and neck 67% of core biopsies were fully diagnostic for treatment purposes compared to 91% in the thorax, abdomen and pelvis. Image-guided core biopsy has a number of cost and safety advantages over surgical excision biopsy and in suitable cases it can obviate the need for surgery in cases of suspected lymphoma. This is especially relevant for elderly patients and those with poor performance status.

  6. Characterization and evaluation of novel film forming polymer for drug delivery.

    Science.gov (United States)

    Mundada, Artish; Satturwar, Prashant; Fulzele, Suniket; Joshi, Sudhir; Dorle, Avinash

    2011-01-01

    DB is a whitish to yellowish resin, characterized initially in terms of solubility, acid value, molecular weight (Mw), polydispersity index (Mw/Mn) and glass transition temperature (Tg). Neat plasticized films of DB (Damar Batu) are investigated for mechanical, water vapor transmission and moisture absorption properties. To improve the mechanical properties of the free films dibutyl sebacate, a hydrophobic plasticizer was added to film composition. The biomaterial was further investigated for sustaining the drug release from spherical units (multiparticulates). The core of pellet was prepared using Diclofenac sodium (10% w/w) as a model drug by extrusion and speronization. The drug containing pellets were coated using DB plasticized film-coating solutions. With 2% coat build-up, sustained drug release up to 10 h was achieved with coating solution containing 20% and 30% w/w (based on DB weight) plasticizers. Less than 3% drug was released in the first 2 h which may be explained in terms of the insolubility of DB and the drug in acidic milieu. The release from pellets coated using DB film coating solution containing 20% and 30% plasticizers followed first order release pattern. DB seems to be a promising film former for pharmaceutical coating due to its reasonably good mechanical properties, low water vapor transmission and sustained release capability.

  7. 媒介融合是一项从核心价值观到技术形态的系统工程%Media Convergence Is System Engineering from the Core Value to Technology Form

    Institute of Scientific and Technical Information of China (English)

    高萍

    2015-01-01

    媒介融合融什么?这不仅是一个传媒业界的实践问题,也是传播学学界亟待阐释的学理问题。媒介融合需要顶层设计;媒介融合是一项从核心价值观到媒介技术形态的网络化系统工程。媒介融合当以社会主义核心价值观观照传媒意识形态和技术形态,以媒介的互动性激活受众的主体性,为用户提供优质的信息增值服务。%What is the Media Convergence? It is not only a question in the field of media industry practice but also a theoretical issue which is urgently to be explained by academic communication. The Top-Level design is required in media convergence; Media convergence is a network of system engineering which covers from the core value to media technological forms. Media convergence should impact media ideology form as well as the technical form based on the core value of socialist ideology, activate the subjectivity of audiences by the interactivity of media, furthermore, provide users with high quality value-added information service.

  8. Excitation and Abundance of C3 in star forming cores:Herschel/HIFI observations of the sight-lines to W31C and W49N

    CERN Document Server

    Mookerjea, B; Stutzki, J; Cernicharo, J; Goicoechea, J R; De Luca, M; Bell, T A; Gupta, H; Gerin, M; Persson, C M; Sonnentrucker, P; Makai, Z; Black, J; Boulanger, F; Coutens, A; Dartois, E; Encrenaz, P; Falgarone, E; Geballe, T; Godard, B; Goldsmith, P F; Gry, C; Herbst, P Hennebelle E; Hily-Blant, P; Joblin, C; Kaźmierczak, M; Ko\\los, R; Kre\\lowski, J; Lis, D C; Martin-Pintado, J; Menten, K M; Monje, R; Pearson, J C; Perault, M; Phillips, T G; Plume, R; Salez, M; Schlemmer, S; Schmidt, M; Teyssier, D; Vastel, C; Yu, S; Dieleman, P; Güsten, R; Honingh, C E; Morris, P; Roelfsema, P; Schieder, R; Tielens, A G G M; Zmuidzinas, J

    2010-01-01

    We present spectrally resolved observations of triatomic carbon (C3) in several ro-vibrational transitions between the vibrational ground state and the low-energy nu2 bending mode at frequencies between 1654-1897 GHz along the sight-lines to the submillimeter continuum sources W31C and W49N, using Herschel's HIFI instrument. We detect C3 in absorption arising from the warm envelope surrounding the hot core, as indicated by the velocity peak position and shape of the line profile. The sensitivity does not allow to detect C3 absorption due to diffuse foreground clouds. From the column densities of the rotational levels in the vibrational ground state probed by the absorption we derive a rotation temperature (T_rot) of ~50--70 K, which is a good measure of the kinetic temperature of the absorbing gas, as radiative transitions within the vibrational ground state are forbidden. It is also in good agreement with the dust temperatures for W31C and W49N. Applying the partition function correction based on the derived...

  9. Well-Hidden Grain Boundary in the Monolayer MoS2 Formed by a Two-Dimensional Core-Shell Growth Mode.

    Science.gov (United States)

    Zhang, Wenting; Lin, Yue; Wang, Qi; Li, Weijie; Wang, Zhifeng; Song, Jiangluqi; Li, Xiaodong; Zhang, Lijie; Zhu, Lixin; Xu, Xiaoliang

    2017-09-22

    Guided by the hexagonal lattice symmetry, triangles and hexagons are the most basic morphological units for two-dimensional (2D) transition metal dichalcogenides (TMDs) synthesized by chemical vapor deposition (CVD). Also, it is widely acknowledged that these units start from the single nucleation site and then grow epitaxially. Accordingly, the triangular monolayer (ML) samples are generally considered as single crystals. Here, we report a 2D core-shell growth mode in the CVD process for ML-MoS2, which leads to one kind of "pseudo" single-crystal triangles containing triangular outline grain boundaries (TO-GBs). It is difficult to be optically distinguished from the "true" single-crystal triangles. The weakening of Raman peaks and the remarkable enhancement of photoluminescence (PL) are found at the built-in TO-GBs, which could be useful for high-performance optoelectronics. In addition, the electrical measurements indicate that the TO-GBs are conductive. Furthermore, TO-GBs and the common grain boundaries (CO-GBs) can coexist in a single flake, whereas their optical visibility and optical modifications (Raman and PL) are quite different. This work is helpful in further understanding the growth mechanism of 2D TMD materials and may also play a significant role in related nanodevices.

  10. ZnO-Ag core shell nanocomposite formed by green method using essential oil of wild ginger and their bactericidal and cytotoxic effects

    Science.gov (United States)

    Azizi, Susan; Mohamad, Rosfarizan; Rahim, Raha Abdul; Moghaddam, Amin Boroumand; Moniri, Mona; Ariff, Arbakariya; Saad, Wan Zuhainis; Namvab, Farideh

    2016-10-01

    In this paper, a novel green method for fabrication of zinc oxide-silver (ZnO-Ag) core-shell nanocomposite using essential oil of ginger (EO-G) is reported. The EO-G played two significant roles in the synthesis process: it could act as a reaction media for the formation of ZnO and reduce Ag+ to Ag0. The bioformed ZnO-Ag nanocomposite was compared with pure biosynthesized ZnO-NPs and characterized by UV-vis spectroscopy, TEM, EDX, XRD and FTIR. The characterization results confirmed that Ag-NPs had been embedded in ZnO hexagonal nanoparticles. Six Gram positive and negative pathogens were used to investigate the antibacterial effects of these samples. Ag-doping improves the bactericidal activity of ZnO-NPs. In vitro cytotoxicity studies on Vero cells, a dose dependent toxicity with non-toxic effect of concentration below 100 μg/mL was shown for ZnO-Ag nanocomposite. The biosynthesized ZnO-Ag nanocomposites were found to be comparable to those obtained from the conventional methods using hazardous materials which can be an excellent alternative for the synthesis of ZnO-Ag using biomass.

  11. New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.

    Science.gov (United States)

    Carneiro, Paula F; do Nascimento, Samara B; Pinto, Antonio V; Pinto, Maria do Carmo F R; Lechuga, Guilherme C; Santos, Dilvani O; dos Santos Júnior, Helvécio M; Resende, Jackson A L C; Bourguignon, Saulo C; Ferreira, Vitor F

    2012-08-15

    New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.

  12. Long-term evaluation of the degradation behavior of three apatite-forming calcium phosphate cements.

    Science.gov (United States)

    An, Jie; Liao, Hongbing; Kucko, Nathan W; Herber, Ralf-Peter; Wolke, Joop G C; van den Beucken, Jeroen J J P; Jansen, John A; Leeuwenburgh, Sander C G

    2016-05-01

    Calcium phosphate cements (CPCs) are injectable bone substitutes with a long clinical history because of their biocompatibility and osteoconductivity. Nevertheless, their cohesion upon injection into perfused bone defects as well as their long-term degradation behavior remain major clinical challenges. Therefore, the long-term degradation behavior of two types of α-tricalcium phosphate-based, apatite-forming CPCs was compared to a commercially available apatite-forming cement, that is HydroSet™ . Carboxyl methylcellulose (CMC) was used as cohesion promotor to improve handling properties of the two experimental cements, whereas poly (d, l-lactic-co-glycolic) acid (PLGA) microparticles were added to introduce macroporosity and stimulate CPC degradation. All three CPCs were injected into defects drilled into rabbit femoral condyles and explanted after 4, 12, or 26 weeks, after which the bone response was assessed both qualitatively and quantitatively. CPCs without PLGA microparticles degraded only at the periphery of the implants, while the residual CPC volume was close to 90%. On the contrary, bone ingrowth was observed not only at the periphery of the CPC, but also throughout the center of the implants after 26 weeks of implantation for the PLGA-containing CPCs with a residual CPC volume of approximately 55%. In conclusion, it was shown that CPC containing CMC and PLGA was able to induce partial degradation of apatite-forming CPCs and concomitant replacement by bone tissue.

  13. Two-Dimensional Cutting (TDC) Vitrectome: In Vitro Flow Assessment and Prospective Clinical Study Evaluating Core Vitrectomy Efficiency versus Standard Vitrectome.

    Science.gov (United States)

    Pavlidis, Mitrofanis

    2016-01-01

    Purpose. To evaluate comparative aspiration flow performance and also vitrectomy operating time efficiency using a double-cutting open port vitreous cutting system incorporated in a two-dimensional cutting (TDC, DORC International) vitrectome design versus standard vitreous cutter. Methods. In vitro investigations compared aspiration flow rates in artificial vitreous humor at varying cutter speeds and vacuum levels using a TDC vitrectome and a standard vitrectome across different aspiration pump systems. A prospective single-centre clinical study evaluated duration of core vitrectomy in 80 patients with macular pucker undergoing 25-gauge or 27-gauge vitrectomy using either a TDC vitrectome at 16,000 cuts per minute (cpm) or standard single-cut vitrectome, combined with a Valve Timing intelligence (VTi) pump system (EVA, DORC International). Results. Aspiration flow rates remained constant independent of TDC vitrectome cut rate, while flow rates decreased linearly at higher cutter speeds using a classic single-blade vitrectome. Mean duration of core vitrectomy surgeries using a TDC vitreous cutter system was significantly (p < 0.001) shorter than the mean duration of core vitrectomy procedures using a single-cut vitrectome of the same diameter (reduction range, 34%-50%). Conclusion. Vitrectomy surgery performed using a TDC vitrectome was faster than core vitrectomy utilizing a standard single-action vitrectome at similar cut speeds.

  14. Two-Dimensional Cutting (TDC Vitrectome: In Vitro Flow Assessment and Prospective Clinical Study Evaluating Core Vitrectomy Efficiency versus Standard Vitrectome

    Directory of Open Access Journals (Sweden)

    Mitrofanis Pavlidis

    2016-01-01

    Full Text Available Purpose. To evaluate comparative aspiration flow performance and also vitrectomy operating time efficiency using a double-cutting open port vitreous cutting system incorporated in a two-dimensional cutting (TDC, DORC International vitrectome design versus standard vitreous cutter. Methods. In vitro investigations compared aspiration flow rates in artificial vitreous humor at varying cutter speeds and vacuum levels using a TDC vitrectome and a standard vitrectome across different aspiration pump systems. A prospective single-centre clinical study evaluated duration of core vitrectomy in 80 patients with macular pucker undergoing 25-gauge or 27-gauge vitrectomy using either a TDC vitrectome at 16,000 cuts per minute (cpm or standard single-cut vitrectome, combined with a Valve Timing intelligence (VTi pump system (EVA, DORC International. Results. Aspiration flow rates remained constant independent of TDC vitrectome cut rate, while flow rates decreased linearly at higher cutter speeds using a classic single-blade vitrectome. Mean duration of core vitrectomy surgeries using a TDC vitreous cutter system was significantly (p<0.001 shorter than the mean duration of core vitrectomy procedures using a single-cut vitrectome of the same diameter (reduction range, 34%–50%. Conclusion. Vitrectomy surgery performed using a TDC vitrectome was faster than core vitrectomy utilizing a standard single-action vitrectome at similar cut speeds.

  15. Core shroud corner joints

    Science.gov (United States)

    Gilmore, Charles B.; Forsyth, David R.

    2013-09-10

    A core shroud is provided, which includes a number of planar members, a number of unitary corners, and a number of subassemblies each comprising a combination of the planar members and the unitary corners. Each unitary corner comprises a unitary extrusion including a first planar portion and a second planar portion disposed perpendicularly with respect to the first planar portion. At least one of the subassemblies comprises a plurality of the unitary corners disposed side-by-side in an alternating opposing relationship. A plurality of the subassemblies can be combined to form a quarter perimeter segment of the core shroud. Four quarter perimeter segments join together to form the core shroud.

  16. Analysis of Post-LOCA Core Inlet Blockage to Evaluate In-vessel Downstream Effect in APR1400

    Energy Technology Data Exchange (ETDEWEB)

    Bang, Young Seok [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-10-15

    The method was developed to have a conservatism to cover the uncertainty of analysis and the acceptance is judged by the representative bounding estimation. However, the important safety parameters such as the available driving head need to be confirmed by the plant specific calculation. Also an interaction between the debris induced head loss and the core flow rate needs to be explained because the head loss induced by debris in actual condition may reduce the core inflow rate faster. To confirm the safety parameters, in this study, thermal-hydraulic response considering the core inlet blockage (CIB) by debris during LTCC process following a double-ended guillotine break of cold leg (CLB), one of hot leg (HLB) and one of intermediate leg (ILB) of the APR1400 were calculated, respectively. MARS-KS 1.3 code has been used. The CIB has been modeled by the closure of valves to the core in exponential manner with time to observe the behavior near the complete blockage. To understand the effect of core inlet blockage (CIB) during a long term core cooling (LTCC) phase following a loss-of-coolant accident (LOCA) in the light of in-vessel downstream effect (IDE) of Generic Safety Issue (GSI) 191, double-ended guillotine break of hot leg (HLB), one of cold leg (CLB) and one of intermediate leg (ILB) were calculated, respectively. And the important safety parameters such as the available driving head and the head loss due to debris were calculated using MARS-KS code and discussed in comparison with the WCAP method. As a result, a little delayed heatup behavior of the fuel cladding was found for all the cases, which due to the redistribution of flow within the core after blockage.

  17. Forming a Belief: The Contribution of Comprehension to the Evaluation and Persuasive Impact of Argumentative Text

    Science.gov (United States)

    Diakidoy, Irene-Anna N.; Christodoulou, Stelios A.; Floros, Georgios; Iordanou, Kalypso; Kargopoulos, Philip V.

    2015-01-01

    Background: Research has shown substantial belief change as a result of reading text and the pervasive influence of prior belief in the evaluation of short arguments. Both outcomes have been attributed to the depth to which the text or the argument has been processed. This study brings together critical thinking and text comprehension research by…

  18. Rheology as a tool for evaluation of melt processability of innovative dosage forms

    DEFF Research Database (Denmark)

    Aho, Johanna Maaria; Boetker, Johan P; Baldursdottir, Stefania

    2015-01-01

    for the process simulations which are also becoming increasingly important. The authors aim to give an overview to the basics of rheology and summarize examples of the studies where rheology has been utilized in setting up or evaluating extrusion processes. Furthermore, examples of different experimental set...

  19. Qualitative evaluation of a form for standardized information exchange between orthopedic surgeons and occupational physicians

    NARCIS (Netherlands)

    E. Faber (Elske); A. Burdorf (Alex); A.L. van Staa (AnneLoes); H.S. Miedema (Harald); J.A.N. Verhaar (Jan)

    2006-01-01

    textabstractBACKGROUND: Both occupational physicians and orthopedic surgeons can be involved in the management of work relevant musculoskeletal disorders. These physicians hardly communicate with each other and this might lead to different advice to the patient. Therefore, we evaluated a standardize

  20. Closed-form evaluation of two-dimensional static lattice sums

    Science.gov (United States)

    Yakubovich, S.; Drygas, P.; Mityushev, V.

    2016-11-01

    Closed-form formulae for the conditionally convergent two-dimensional (2D) static lattice sums S2 (for conductivity) and T2 (for elasticity) are deduced in terms of the complete elliptic integrals of the first and second kind. The obtained formulae yield asymptotic analytical formulae for the effective tensors of 2D composites with circular inclusions up to the third order in concentration. Exact relations between S2 and T2 for different lattices are established. In particular, the value S2=π for the square and hexagonal arrays is discussed and T2=π/2 for the hexagonal is deduced.

  1. Evaluation of a short-form of the Berg Card Sorting Test.

    Science.gov (United States)

    Fox, Christopher J; Mueller, Shane T; Gray, Hilary M; Raber, Jacob; Piper, Brian J

    2013-01-01

    The Psychology Experimental Building Language http://pebl.sourceforge.net/ Berg Card Sorting Test is an open-source neurobehavioral test. Participants (N = 207, ages 6 to 74) completed the Berg Card Sorting Test. Performance on the first 64 trials were isolated and compared to that on the full-length (128 trials) test. Strong correlations between the short and long forms (total errors: r = .87, perseverative response: r = .83, perseverative errors r = .77, categories completed r = .86) support the Berg Card Sorting Test-64 as an abbreviated alternative for the full-length executive function test.

  2. Evaluation of a Short-Form of the Berg Card Sorting Test

    OpenAIRE

    Fox, Christopher J.; Mueller, Shane T.; Hilary M Gray; Jacob Raber; Piper, Brian J.

    2013-01-01

    The Psychology Experimental Building Language http://pebl.sourceforge.net/ Berg Card Sorting Test is an open-source neurobehavioral test. Participants (N = 207, ages 6 to 74) completed the Berg Card Sorting Test. Performance on the first 64 trials were isolated and compared to that on the full-length (128 trials) test. Strong correlations between the short and long forms (total errors: r = .87, perseverative response: r = .83, perseverative errors r = .77, categories completed r = .86) suppor...

  3. Core-shell hybrid nanocapsules for oral delivery of camptothecin: formulation development, in vitro and in vivo evaluation

    Science.gov (United States)

    Ünal, Hale; d'Angelo, Ivana; Pagano, Ester; Borrelli, Francesca; Izzo, Angelo; Ungaro, Francesca; Quaglia, Fabiana; Bilensoy, Erem

    2015-01-01

    The objective of this study was to design and in vitro-in vivo evaluate oral nanocapsules prepared from amphiphilic cyclodextrins (CDs) or poly-ɛ-caprolactone (PCL) for the effective oral delivery of an anticancer agent, camptothecin (CPT). CPT-loaded anionic and Chitosan (CS)-coated cationic nanocapsules were prepared and characterized in vitro. Morphological analysis was performed by scanning electron microscope (SEM). CPT release profile was evaluated using dialysis method under sink conditions. To determine the protective effect and drug stability provided by nanocapsules, all the formulations were incubated in simulated gastrointestinal media. Measurement of mucoadhesive tendency of CPT-loaded nanocapsules was realized by turbidimetric method. Penetration of nanocapsules was performed through an artificial mucus model. The permeability of CPT in solution form and bound to nanocapsule formulations were demonstrated across Caco-2 cell line. Finally, the intestinal uptake of nanocapsules was evaluated in vivo, in a mouse model. Both anionic and cationic formulations were in the range of 180-220 nm with a narrow size distribution and desired zeta potential values. CPT-loaded nanocapsules were found to be stable in simulated gastrointestinal media. Turbidimetric measurements confirmed the interaction between nanoparticles and mucin. Penetration of CPT through an artificial mucus gel layer was higher with CS-coated nanocapsules in accordance with the results obtained from permeability studies across Caco-2 cell line. In vivo animal studies confirmed that the intestinal uptake of nanocapsules was significantly higher with cationic nanocapsules. CPT-loaded positively charged CD nanocapsules might be an attractive and promising treatment for oral chemotherapy.

  4. THE INTERNET AS INFORMATIONAL SOURCE FOR MIS: THE PROCESSES OF CAPTATION AND THE FORMS OF EVALUATION

    Directory of Open Access Journals (Sweden)

    Edson Crescitelli

    2007-01-01

    Full Text Available This article discusses the use and the ways of assessment of the internet as a source of information due to the agility that this way has been providing to the Marketing Information System, which also shows to be fragile in terms of reliability of the available information The study consists of an exploratory research, which includes literature review and multiple case studies, and presents as its objective the understanding of how the internet is used in the processes of data source definition and evaluation in a company, from the user’s point of view. The results indicate that the internet is an important source of information, but there is little systematization in the information collection and the sources evaluation is based only on the users’ individual and practical knowledge

  5. Clinical evaluation of carbon fiber reinforced carbon endodontic post, glass fiber reinforced post with cast post and core: A one year comparative clinical study

    Directory of Open Access Journals (Sweden)

    Preethi G

    2008-01-01

    Full Text Available Aim: Restoring endodontically treated teeth is one of the major treatments provided by the dental practitioner. Selection and proper use of restorative materials continues to be a source of frustration for many clinicians. There is controversy surrounding the most suitable choice of restorative material and the placement method that will result in the highest probability of successful treatment. This clinical study compares two different varieties of fiber posts and one cast post and core in terms of mobility of crown margin under finger pressure, recurrent caries detected at the crown margin, fracture of the restoration, fracture of the root and periapical and periodontal pathology requiring crown removal over the period of 12months as evaluated by clinical and radiographical examination. Materials and Methods: 30 root canal treated, single rooted maxillary anterior teeth of 25 patients in the age range of 18-60 years where a post retained crown was indicated were selected for the study between January 2007 and August 2007; and prepared in a standard clinical manner. It was divided into 3 groups of 10 teeth in each group. After post space preparation, the Carbon fiber and Glass fiber reinforced posts were cemented with Scotch bond multipurpose plus bonding agent and RelyX adhesive resin cement in the first and second groups respectively. The Cast post and cores were cemented with Zinc Phosphate cement in the third group. Following post- cementation, the preparation was further refined and a rubber base impression was taken for metal-ceramic crowns which was cemented with Zinc Phosphate cement. A baseline periapical radiograph was taken once each crown was cemented. All patients were evaluated after one week (baseline, 3 months, 6 months and one year for following characteristics mobility of crown margin under finger pressure, recurrent caries detected at the crown margin, fracture of the restoration, fracture of the root and periapical and

  6. Forms and Levels of Integration: Evaluation of an Interdisciplinary Team-Building Project

    Directory of Open Access Journals (Sweden)

    Andrea Armstrong

    2013-01-01

    Full Text Available Team science models are frequently promoted as the best way to study complex societal and environmental problems. Despite increasing popularity, there is relatively little research on the processes and mechanisms that facilitate the emergence of integration of interdisciplinary teams. This article evaluates a suite of recent team-building and grant-writing activities designed to address water management in the Western U.S. We use qualitative methods to document the emergence of integrative capacity at the individual, group, and institutional levels, with particular attention to the role of graduate students and non-academic practitioners in a team science planning project. Our findings highlight the importance of social integration as a basis for conceptual integration and an ability to relate these concepts to real-world problems. The findings also demonstrate the value of qualitative evaluation measures of team readiness, capacity, and intellectual outputs to complement conventional evaluation indicators that rely on quantitative scientific outputs, particularly for team science projects still in the planning stages.

  7. Development and evaluation of modified release wax matrix tablet dosage form for tramadol hydrochloride

    Directory of Open Access Journals (Sweden)

    Paresh Ramesh Mahaparale

    2015-01-01

    Full Text Available The objective of this study was to develop modified release dosage forms of tramadol hydrochloride using wax matrix system by melt granulation method. The effect of various waxes, concentration of waxes, effect of excipients on the release profile of drug from wax matrix system was studied. Release retardant effect was observed in the order of hydrogenated vegetable oil (HVO > compritol >precirol. This may be due to more lipophilicity imparted by HVO than any other waxy substances. It was also observed that as ratio of drug: Wax was increased, it sustained release of drug for more time. This may be due to proper embedment/entrapment of drug in sufficient wax matrix system. In case of excipients, release retardant effect was found in order of dicalcium phosphate (DCP > microcrystalline cellulose (MCC > lactose. DCP is insoluble which helps in release retardation of drug. MCC is hydrophilic swellable polymer which showed release of drug by swelling. Lactose is soluble excipient which get dissolved and formed channels for entry of dissolution medium and release of drug occurred by erosion mechanism. Wax matrix tablets were found to be stable.

  8. Nasal administration of metoclopramide from different dosage forms: in vitro, ex vivo, and in vivo evaluation.

    Science.gov (United States)

    Tas, Cetin; Ozkan, Cansel Kose; Savaser, Ayhan; Ozkan, Yalcin; Tasdemir, Umut; Altunay, Hikmet

    2009-04-01

    Nasal drug delivery is an interesting route of administration for metoclopramide hydrochloride (MTC) in preventing different kind of emesis. Currently, the routes of administration of antiemetics are oral or intravenous, although patient compliance is often impaired by the difficulties associated with acute emesis or invasiveness of parenteral administration. In this perspective, nasal dosage forms (solution, gel, and lyophilized powder) of MTC were prepared by using a mucoadhesive polymer sodium carboxymethylcellulose (NaCMC). In vitro and ex vivo drug release studies were performed in a modified horizontal diffusion chamber with cellulose membrane and excised cattle nasal mucosa as diffusion barriers. The tolerance of nasal mucosa to the formulation and its components were investigated using light microscopy. In vivo studies were carried out for the optimized formulations in sheep and the pharmacokinetics parameters were compared with oral solution and IV dosage form. The release of MTC from solution and powder formulations was found to be higher than gel formulation (p nasal bioavailability of gel is higher than those of solution and powder (p nasal residence time and thereby nasal absorption.

  9. A theoretical approach to evaluate the release rate of acetaminophen from erosive wax matrix dosage forms.

    Science.gov (United States)

    Agata, Yasuyoshi; Iwao, Yasunori; Shiino, Kai; Miyagishima, Atsuo; Itai, Shigeru

    2011-07-29

    To predict drug dissolution and understand the mechanisms of drug release from wax matrix dosage forms containing glyceryl monostearate (GM; a wax base), aminoalkyl methacrylate copolymer E (AMCE; a pH-dependent functional polymer), and acetaminophen (APAP; a model drug), we tried to derive a novel mathematical model with respect to erosion and diffusion theory. Our model exhibited good agreement with the whole set of experimentally obtained values pertaining to APAP release at pH 4.0 and pH 6.5. In addition, this model revealed that the eroding speed of wax matrices was strongly influenced by the loading content of AMCE, but not that of APAP, and that the diffusion coefficient increased as APAP loading decreased and AMCE loading increased, thus directly defining the physicochemical properties of erosion and diffusion. Therefore, this model might prove a useful equation for the precise prediction of dissolution and for understanding the mechanisms of drug release from wax matrix dosage forms. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Development and evaluation of fast forming nano-composite hydrogel for ocular delivery of diclofenac.

    Science.gov (United States)

    Li, Xingyi; Zhang, Zhaoliang; Chen, Hao

    2013-05-01

    In this paper, a fast forming nano-composite hydrogel was developed for potential application in ocular drug delivery. The optical transmission (OT) as well as rheological properties of nano-composite hydrogel was characterized. The developed nano-composite hydrogel given a high diclofenac micelles loading and provided a sustained release manner of diclofenac within 6h. The developed nano-composite hydrogel formulation was administrated into the eye as flowable solution, quickly forming a hydrogel that is able to resist of the blinking and flushing of tear, yet resulting in the prolonged residence time of pre-corneal. In vivo eye irritation test suggested that the developed nano-composite hydrogel was none-eye irritation might be suitable for various ocular applications. In vivo pharmacokinetic study indicated that the developed nano-composite hydrogel could significantly increase the bioavailability of diclofenac and maintain the concentration of diclofenac in aqueous humor above MEC at least 24h after administration as compared with that of the commercial diclofenac sodium eye drops, which might be able to reduce the frequency of administration for patients.

  11. Ice cores

    DEFF Research Database (Denmark)

    Svensson, Anders

    2014-01-01

    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...

  12. Ice cores

    DEFF Research Database (Denmark)

    Svensson, Anders

    2014-01-01

    Ice cores from Antarctica, from Greenland, and from a number of smaller glaciers around the world yield a wealth of information on past climates and environments. Ice cores offer unique records on past temperatures, atmospheric composition (including greenhouse gases), volcanism, solar activity......, dustiness, and biomass burning, among others. In Antarctica, ice cores extend back more than 800,000 years before present (Jouzel et al. 2007), whereas. Greenland ice cores cover the last 130,000 years...

  13. Prospective evaluation of new 22 gauge endoscopic ultrasound core needle using capillary sampling with stylet slow-pull technique for intra-abdominal solid masses.

    Science.gov (United States)

    Paik, Woo Hyun; Park, Yangsoon; Park, Do Hyun; Hong, Seung-Mo; Lee, Byung Uk; Choi, Jun-Ho; Lee, Sang Soo; Seo, Dong-Wan; Lee, Sung Koo; Kim, Myung-Hwan

    2015-03-01

    The aim of this study was to evaluate the adequacy and diagnostic yield of the histologic core obtained with a 22 G endoscopic ultrasound histology needle using capillary sampling with stylet slow-pull technique without on-site cytopathologist. No standard technique for new EUS histology needle has been established. A total of 125 consecutive patients with intra-abdominal solid masses were enrolled prospectively between October 2011 and March 2013. EUS-guided fine needle biopsy (EUS-FNB) with a 22 G histology needle using capillary sampling with stylet slow-pull technique was performed. A total of 133 EUS-FNB procedures targeting the pancreas, lymph node, retroperitoneal mass, ampulla of Vater, gallbladder, common bile duct, duodenum, and liver were performed in 125 patients. EUS-FNB was technically feasible in all cases, and a visible core was obtained in 128 cases (96%). Histologic core specimens suitable for pathologic assessment were reported in 111 cases (83%). There were no procedure-related adverse events. According to the determinants of malignancy with EUS-FNB, the sensitivity, specificity, positive and negative predictive values, and accuracy were 85%, 98%, 99%, 77%, and 89%, respectively. In addition, histologic architecture with or without immunohistochemical staining of the core biopsy specimens was useful for pathologic confirmation in 101 cases (76%). A 22 G EUS-FNB using capillary sampling with stylet slow-pull technique showed a high diagnostic yield and histologic core acquisition for the histologic diagnosis of various intra-abdominal masses without an on-site cytopathologist. Furthermore, a histologic core with or without immunohistochemical staining was helpful for clinical decision making in 76% of the intra-abdominal solid masses.

  14. Beyond packing of hard spheres: The effects of core softness, non-additivity, intermediate-range repulsion, and many-body interactions on the glass-forming ability of bulk metallic glasses

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Kai; Fan, Meng; Liu, Yanhui; Schroers, Jan [Department of Mechanical Engineering and Materials Science, Yale University, New Haven, Connecticut 06520 (United States); Center for Research on Interface Structures and Phenomena, Yale University, New Haven, Connecticut 06520 (United States); Shattuck, Mark D. [Department of Mechanical Engineering and Materials Science, Yale University, New Haven, Connecticut 06520 (United States); Department of Physics and Benjamin Levich Institute, The City College of the City University of New York, New York, New York 10031 (United States); O’Hern, Corey S. [Department of Mechanical Engineering and Materials Science, Yale University, New Haven, Connecticut 06520 (United States); Center for Research on Interface Structures and Phenomena, Yale University, New Haven, Connecticut 06520 (United States); Department of Physics, Yale University, New Haven, Connecticut 06520 (United States); Department of Applied Physics, Yale University, New Haven, Connecticut 06520 (United States)

    2015-11-14

    When a liquid is cooled well below its melting temperature at a rate that exceeds the critical cooling rate R{sub c}, the crystalline state is bypassed and a metastable, amorphous glassy state forms instead. R{sub c} (or the corresponding critical casting thickness d{sub c}) characterizes the glass-forming ability (GFA) of each material. While silica is an excellent glass-former with small R{sub c} < 10{sup −2} K/s, pure metals and most alloys are typically poor glass-formers with large R{sub c} > 10{sup 10} K/s. Only in the past thirty years have bulk metallic glasses (BMGs) been identified with R{sub c} approaching that for silica. Recent simulations have shown that simple, hard-sphere models are able to identify the atomic size ratio and number fraction regime where BMGs exist with critical cooling rates more than 13 orders of magnitude smaller than those for pure metals. However, there are a number of other features of interatomic potentials beyond hard-core interactions. How do these other features affect the glass-forming ability of BMGs? In this manuscript, we perform molecular dynamics simulations to determine how variations in the softness and non-additivity of the repulsive core and form of the interatomic pair potential at intermediate distances affect the GFA of binary alloys. These variations in the interatomic pair potential allow us to introduce geometric frustration and change the crystal phases that compete with glass formation. We also investigate the effect of tuning the strength of the many-body interactions from zero to the full embedded atom model on the GFA for pure metals. We then employ the full embedded atom model for binary BMGs and show that hard-core interactions play the dominant role in setting the GFA of alloys, while other features of the interatomic potential only change the GFA by one to two orders of magnitude. Despite their perturbative effect, understanding the detailed form of the intermetallic potential is important for

  15. Corrosion evaluation of zirconium doped oxide coatings on aluminum formed by plasma electrolytic oxidation.

    Science.gov (United States)

    Bajat, Jelena; Mišković-Stanković, Vesna; Vasilić, Rastko; Stojadinović, Stevan

    2014-01-01

    The plasma electrolytic oxidation (PEO) of aluminum in sodium tungstate (Na(2)WO(4) · (2)H(2)O) and Na(2)WO(4) · (2)H(2)O doped with Zr was analyzed in order to obtain oxide coatings with improved corrosion resistance. The influence of current density in PEO process and anodization time was investigated, as well as the influence of Zr, with the aim to find out how they affect the chemical content, morphology, surface roughness, and corrosion stability of oxide coatings. It was shown that the presence of Zr increases the corrosion stability of oxide coatings for all investigated PEO times. Evolution of EIS spectra during the exposure to 3% NaCl, as a strong corrosive agent, indicated the highest corrosion stability for PEO coating formed on aluminum at 70 mA/cm(2) for 2 min in a zirconium containing electrolyte.

  16. SEM evaluation of resin-carious dentin interfaces formed by two dentin adhesive systems

    Science.gov (United States)

    Hsu, Kuang-Wei; Marshall, Sally J.; Pinzon, Lilliam M.; Watanabe, Larry; Saiz, Eduardo; Marshall, Grayson W.

    2008-01-01

    Objectives We investigated the influence of dentin tubule direction and identifiable zone of carious dentin on the microstructure and the thickness of the hybrid-like layer (HL) formed by self-etch and etch-rinse adhesive systems. Methods An etch-rinse and a self-etching adhesive were bonded to dentin carious zones divided into groups with parallel or perpendicular orientation relative to the dentin tubules at the resin-carious dentin interface (N = 5/variable). Bonds were prepared to each of the four zones of carious dentin apparent after staining with Caries Detector: pink, light pink, transparent and apparently normal Six non-carious third molars were controls. The microstructure and thickness of the HL were determined by SEM.and compared using three-way ANOVA and Tukey's multiple comparisons (pcarious zone. PMID:18155289

  17. Continuous Cast Forming Machine with Vertical Core-Filling for Copper Cladding Aluminum Composite Bars%铜包铝复合扁排立式充芯连铸设备的研制

    Institute of Scientific and Technical Information of China (English)

    张建宇; 王屹峰; 万长清; 曾祥勇; 蔡鹏; 吴春京

    2013-01-01

    A new continuous core-filling casting machine for copper cladding aluminum composite bars was designed and produced. The machine installed the upper and bottom graphite crucibles in the vertical direction for heating inner core of aluminum and the outer layer of copper. During continuous casting, copper tube was formed in the crystallizer continuously firstly, then liquid aluminum was injected into the copper tube through mandrel. Finally, the metallurgical bonded layer was formed by inter-diffusion between copper and aluminum. The copper cladding aluminum composite bars with the core thickness of 10 mm and the sheath thickness of 2 mm and the width of 60 mm were fabricated successfully by the machine.%设计和制造了一台制备铜包铝复合扁排的立式充芯连铸试验设备,该设备的特点是在高度方向上设置上下两个加热坩埚分别熔化铜和铝;外层铜管在结晶器中首先形成,铝液随之通过充芯管充填到铜管中,铜、铝界面通过互扩散实现冶金结合.利用此设备,成功地连铸出铜层厚度为2 mm,芯部铝厚度为10 mm,宽为60 mm的铜包铝复合扁排.

  18. Preliminary evaluation of alternative waste form solidification processes. Volume I. Identification of the processes.

    Energy Technology Data Exchange (ETDEWEB)

    Treat, R.L.; Nesbitt, J.F.; Blair, H.T.; Carter, J.G.; Gorton, P.S.; Partain, W.L.; Timmerman, C.L.

    1980-04-01

    This document contains preconceptual design data on 11 processes for the solidification and isolation of nuclear high-level liquid wastes (HLLW). The processes are: in-can glass melting (ICGM) process, joule-heated glass melting (JHGM) process, glass-ceramic (GC) process, marbles-in-lead (MIL) matrix process, supercalcine pellets-in-metal (SCPIM) matrix process, pyrolytic-carbon coated pellets-in-metal (PCCPIM) matrix process, supercalcine hot-isostatic-pressing (SCHIP) process, SYNROC hot-isostatic-pressing (SYNROC HIP) process, titanate process, concrete process, and cermet process. For the purposes of this study, it was assumed that each of the solidification processes is capable of handling similar amounts of HLLW generated in a production-sized fuel reprocessing plant. It was also assumed that each of the processes would be enclosed in a shielded canyon or cells within a waste facility located at the fuel reprocessing plant. Finally, it was assumed that all of the processes would be subject to the same set of regulations, codes and standards. Each of the solidification processes converts waste into forms that may be acceptable for geological disposal. Each process begins with the receipt of HLLW from the fuel reprocessing plant. In this study, it was assumed that the original composition of the HLLW would be the same for each process. The process ends when the different waste forms are enclosed in canisters or containers that are acceptable for interim storage. Overviews of each of the 11 processes and the bases used for their identification are presented in the first part of this report. Each process, including its equipment and its requirements, is covered in more detail in Appendices A through K. Pertinent information on the current state of the art and the research and development required for the implementation of each process are also noted in the appendices.

  19. In Vitro Evaluation of Various Surface Treatments of Fiber Posts on the Bond Strength to Composite Core

    Directory of Open Access Journals (Sweden)

    Sareh Nadalizadeh

    Full Text Available Introduction: The reliable bond at the root-post-core interface is critical for the clinical success of post-retained restorations. To decrease the risk of fracture, it is important to optimize the adhesion. Therefore, various post surface treatments have been proposed. The purpose of this study was to investigate the influence of various surface treatments of fiber posts on the bond strength to composite core. Materials & Methods: In this study, 40 fiber reinforced posts were used. After preparing and sectioning them, resulting specimens were divided into four groups (N=28. The posts received different surface treatments such as no surface treatment (control group, preparing with hydrogen peroxide 10%, preparing with silane, preparing with HF and silane. Then, posts were tested in micro tensile testing machine. The results were analyzed by One-Way ANOVA and Dunnett T3 test. Results: The greatest bond strength observed was in treatment with hydrogen peroxide 10% (19.84±8.95 MPa, and the lowest strength was related to the control group (12.44±3.40 MPa. The comparison of the groups with Dunnett T3 test showed that the differences between the groups was statistically significant (α=0.05.Conclusion: Based on the results of this study, preparing with H2O2 -10 % and silane increases the bond strength of FRC posts to the composite core more than the other methods. Generally, the bond strength of posts to the composite core increases by surface treatment.

  20. Evaluation of a connectionless NoC for a real-time distributed shared memory many-core system

    NARCIS (Netherlands)

    Rutgers, Jochem H.; Bekooij, Marco J.G.; Smit, Gerard J.M.

    2012-01-01

    Real-time embedded systems like smartphones tend to comprise an ever increasing number of processing cores. For scalability and the need for guaranteed performance, the use of a connection-oriented network-on-chip (NoC) is advocated. Furthermore, a distributed shared memory architecture is preferred

  1. Comparative evaluation of the indigenous microbial diversity vs. drilling fluid contaminants in the NEEM Greenland ice core.

    Science.gov (United States)

    Miteva, Vanya; Burlingame, Caroline; Sowers, Todd; Brenchley, Jean

    2014-08-01

    Demonstrating that the detected microbial diversity in nonaseptically drilled deep ice cores is truly indigenous is challenging because of potential contamination with exogenous microbial cells. The NEEM Greenland ice core project provided a first-time opportunity to determine the origin and extent of contamination throughout drilling. We performed multiple parallel cultivation and culture-independent analyses of five decontaminated ice core samples from different depths (100-2051 m), the drilling fluid and its components Estisol and Coasol, and the drilling chips collected during drilling. We created a collection of diverse bacterial and fungal isolates (84 from the drilling fluid and its components, 45 from decontaminated ice, and 66 from drilling chips). Their categorization as contaminants or intrinsic glacial ice microorganisms was based on several criteria, including phylogenetic analyses, genomic fingerprinting, phenotypic characteristics, and presence in drilling fluid, chips, and/or ice. Firmicutes and fungi comprised the dominant group of contaminants among isolates and cloned rRNA genes. Conversely, most Proteobacteria and Actinobacteria originating from the ice were identified as intrinsic. This study provides a database of potential contaminants useful for future studies of NEEM cores and can contribute toward developing standardized protocols for contamination detection and ensuring the authenticity of the microbial diversity in deep glacial ice.

  2. Patterns in Nature Forming Patterns in Minds: An Evaluation of an Introductory Physics Unit

    Science.gov (United States)

    Sheaffer, Christopher Ryan

    Educators are increasingly focused on the process over the content. In science especially, teachers want students to understand the nature of science and investigation. The emergence of scientific inquiry and engineering design teaching methods have led to the development of new teaching and evaluation methods that concentrate on steps in a process rather than facts in a topic. Research supports the notion that an explicit focus on the scientific process can lead to student science knowledge gains. In response to new research and standards many teachers have been developing teaching methods that seem to work well in their classrooms, but lack the time and resources to test them in other classroom environments. A high school Physics teacher (Bradford Hill) has developed a unit called Patterns in Nature (PIN) with objectives relating mathematical modeling to the scientific process. Designed for use in his large public school classroom, the unit was taken and used in a charter school with small classes. This study looks at specifically whether or not the PIN unit effectively teaches students how to graph the data they gather and fit an appropriate mathematical pattern, using that model to predict future measurements. Additionally, the study looks at the students' knowledge and views about the nature of science and the process of scientific investigation as it is affected by the PIN unit. Findings show that students are able to identify and apply patterns to data, but have difficulties explaining the meaning of the math. Students' show increases in their knowledge of the process of science, and the majority develop positive views about science in general. A major goal of this study is to place this unit in the cyclical process of Design-Based Research and allow for Pattern in Nature's continuous improvement, development and evaluation. Design-Based Research (DBR) is an approach that can be applied to the implementation and evaluation of classroom materials. This method

  3. Radioiodinated methyl-branched fatty acids: Evaluation of catabolites formed in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Knapp, F.F. Jr.; Reske, S.N.; Kirsch, G.; Ambrose, K.R.; Blystone, S.L.; Goodman, M.M.

    1987-01-01

    Radioiodinated terminal iodophenyl-substituted long-chain fatty acids containing either racemic mono-methyl or geminal dimethyl-branching in the alkyl chain have been shown to exhibit delayed myocardial clearance properties which make these agents useful for the SPECT evaluation of myocardial fatty acid uptake patterns. Although the myocardial clearance rate of 15-(p-iodophenyl)-3-R,S- methylpentadecanoic acid (BMIPP) is considerably delayed, in comparison with the IPPA straight-chain analogue, analysis of the radioiodinated lipids present in the outflow tract of isolated rat hearts administered BMIPP have clearly demonstrated the presence of a polar metabolite. The synthesis of ..beta..-hydroxy fatty acids has been developed to allow investigation of the possible formation of ..beta..-hydroxy catabolites in vivo. The preparation of ..beta..-hydroxy BMIPP and ..beta..-hydroxy IPPA are described, and the possible significance of their formation in vivo discussed. 4 figs.

  4. Current Status of the Transmutation Reactor Technology and Preliminary Evaluation of Transmutation Performance of the KALIMER Core

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Ser Gi; Sim, Yoon Sub; Kim, Yeong Il; Kim, Young Gyum; Lee, Byung Woon; Song, Hoon; Lee, Ki Bog; Jang, Jin Wook; Lee, Dong Uk

    2005-08-15

    Recently the most countries using the nuclear power plants for electricity generation have been faced with the problem of the preparation of the repository for the disposition of the nuclear waste generated from LWR. It was well-known that the issues related with long term risk of the radioactive wastes for the future generations are due only to 1% of the total waste. This small fraction of 1% consists of transuranic (TRU) nuclides such as Pu, Np, Am, Cm and the long lived fission products such as Tc and I. For the transuranic (TRU) nuclides, their half lives range from several years to several hundred thousands years and hence their radioactive toxicity can be lasted over very long time period. This has made the change of the rule of the fast spectrum reactor from the economical use of uranium resource through breeding to the reduction of the nuclear waste through the transmutation. The purpose of this study is to obtain the basic knowledge on the nuclear transmutation technology and to suggest the technical solution ways for the future technology development and enhancement through a survey of the state-of-art of the international research on the nuclear transmutation. The increase of the transmutation rate requires the reduction of the breeding ratio. In fact, the transmutation rate is determined by the breeding ratio. The reduction of the breeding ratio can be achieved by reducing the U-238 content in fuel or increasing the neutron leakage through core boundary or absorbing the neutrons by using some absorbers. However, the reduction of the U-238 content results in the degradation of the fuel Doppler coefficient that is one of the most important safety-related parameters and the reduction of the effective delayed neutron fraction that is related with the controllability of the reactor core. Also, the increase of the transmutation rate can lead to the increase of the coolant void reactivity worth unless some ways to reduce the coolant void reactivity are not

  5. Evaluation of the Iranian Mini Nutritional Assessment Short-Form in Community-dwelling Elderly

    Directory of Open Access Journals (Sweden)

    Aida Malek Mahdavi

    2015-07-01

    Full Text Available Background: This study was aimed to assess agreement and diagnostic accuracy of the Iranian version of Mini Nutritional Assessment short-form (MNA-SF against the original MNA, as a gold standard in community-dwelling elderly. Methods: The full MNA and 9-item MNA-SF comprising questions regarding clinical status, dietary assessment and self-perception of health status and nutri-tion together with mid-arm and calf circumference measurements without in-cluding the body mass index (BMI were completed for 205 volunteers aged 65 or older recruited from all over Markazi Province (Iran. Correlation, diagnostic accuracy and agreement between the MNA-SF and full MNA were calculated. Results: The MNA and the MNA-SF classified 45.4% and 64.4% of the sub-jects as malnourished or at risk of malnutrition, respectively. Substantial agree-ment between the MNA-SF and full MNA was observed (Kappa=0.633. The MNA-SF correlated strongly with the full MNA (r=0.868, P<0.001. The MNA-SF showed high sensitivity (96.77% and negative predictive values (95.89%, relatively high specificity (62.5% and positive predictive values (68.18% and fair accuracy (Area under curve =0.796. Conclusion: Iranian MNA-SF seems to be an applicable screening tool for quick detection of malnutrition or at risk of malnutrition in community-dwelling elderly especially when BMI is unavailable.

  6. An evaluation of the adhesion of solid oral dosage form coatings to the oesophagus.

    Science.gov (United States)

    Smart, John D; Dunkley, Sian; Tsibouklis, John; Young, Simon

    2015-12-30

    There is a requirement for the development of oral dosage forms that are adhesive and allow extended oesophageal residence time for localised therapies, or are non-adhesive for ease of swallowing. This study provides an initial assessment of the in vitro oesophageal retention characteristics of several widely utilised pharmaceutical coating materials. To this end, a previously described apparatus has been used to measure the force required to pull a coated disc-shaped model tablet across a section of excised oesophageal tissue. Of the materials tested, the well-studied mucoadhesive polymer sodium alginate was found to be associated with significant oesophageal adhesion properties that was capable of 'self-repairing'. Hydroxypropylmethylcellulose exhibited less pronounced bioadhesive behaviour and blending this with plasticiser or with low molecular weight polymers and surfactants did not significantly affect this. Low molecular weight water soluble polymers, were found to behave similarly to the uncoated glass control disc. Polysorbates exhibited bioadhesion behaviour that was majorly influenced by the nature of the surfactant. The insoluble polymer ethylcellulose, and the relatively lipophilic surfactant sorbitan monooleate were seen to move more readily than the uncoated disc, suggesting that these may have a role as 'easy-to-swallow' coatings.

  7. Safety evaluation of accident-tolerant FCM fueled core with SiC-coated zircalloy cladding for design-basis-accidents and beyond DBAs

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Ji-Han, E-mail: chunjh@kaeri.re.kr; Lim, Sung-Won; Chung, Bub-Dong; Lee, Won-Jae

    2015-08-15

    Highlights: • Thermal conductivity model of the FCM fuel was developed and adopted in the MARS. • Scoping analysis for candidate FCM FAs was performed to select feasible FA. • Preliminary safety criteria for FCM fuel and SiC/Zr cladding were set up. • Enhanced safety margin and accident tolerance for FCM-SiC/Zr core were demonstrated. - Abstract: The FCM fueled cores proposed as an accident tolerant concept is assessed against the design-basis-accident (DBA) and the beyond-DBA (BDBA) scenarios using MARS code. A thermal conductivity model of FCM fuel is incorporated in the MARS code to take into account the effects of irradiation and temperature that was recently measured by ORNL. Preliminary analyses regarding the initial stored energy and accident tolerant performance were carried out for the scoping of various cladding material candidates. A 16 × 16 FA with SiC-coated Zircalloy cladding was selected as the feasible conceptual design through a preliminary scoping analysis. For a selected design, safety analyses for DBA and BDBA scenarios were performed to demonstrate the accident tolerance of the FCM fueled core. A loss of flow accident (LOFA) scenario was selected for a departure-from-nucleate-boiling (DNB) evaluation, and large-break loss of coolant accident (LBLOCA) scenario for peak cladding temperature (PCT) margin evaluation. A control element assembly (CEA) ejection accident scenario was selected for peak fuel enthalpy and temperature. Moreover, a station blackout (SBO) and LBLOCA without a safety injection (SI) scenario were selected as a BDBA. It was demonstrated that the DBA safety margin of the FCM core is satisfied and the time for operator actions for BDBA s is evaluated.

  8. An In vitro Evaluation of the Effect of Four Dentin Bonding System on the Bond Strength between Quartz Fiber Post and Composite Core

    Directory of Open Access Journals (Sweden)

    Shirinzad M.

    2013-09-01

    Full Text Available Statement of Problem: A strong bond of fiber post to resin core, as well as to dentin would critically ensure the durability of restorations in endodontically treated teeth. Purpose: The purpose of this study was to evaluate the effect of etch-and-rinse dentin bonding systems on the bond strength between resin core and fiber post after application of 24% hydrogen peroxide. Materials and Method: 24 fiber posts (RTD; St. Egèven, France were treated with 24% hydrogen peroxide for 10 minutes. They were randomly divided into 4 groups (n=6 based on the bonding agent used: Group P: Prime&Bond, Group O: One Step, Group S: Single Bond and Group E: Excite. Each group was prepared according to the manufacturer’s instructions. For all posts, a flowable composite core (ÆliteFlo; Bisco, USA was built-up over the bonded area. Each specimen was sectioned to produce 2 sticks, 1mm in thickness and underwent microtensile bond strength (µTBS. Data were analyzed using one-way ANOVA at the 0.05 level. The fractured surfaces of all sticks were evaluated by stereomicroscope (× 20. Scanning electron microscopy(SEM assessment of two sticks from each group was performed to evaluate the surface morphology. Results: The means and SDs of µTBS were: Group P: 10.95±1.74; Group S: 10.25±2.39; Group E: 9.52±2.07; and Group O: 9.12±1.34. There was no statistically significant difference in bond strength means between the groups tested (p> 0.05. Conclusion: The results of this study indicated the bonding agents used had no significant influence on the bond strength of fiber post to composite core.

  9. An In vitro Evaluation of the Effect of Four Dentin Bonding System on the Bond Strength between Quartz Fiber Post and Composite Core

    Directory of Open Access Journals (Sweden)

    Shirinzad M.

    2014-03-01

    Full Text Available Statement of Problem: A strong bond of fiber post to resin core, as well as to dentin would critically ensure the durability of restorations in endodontically treated teeth. Purpose: The purpose of this study was to evaluate the effect of etch-and-rinse dentin bonding systems on the bond strength between resin core and fiber post after application of 24% hydrogen peroxide. Materials and Method: Twenty-four fiber posts (RTD; St. Egèven, France were treated with 24% hydrogen peroxide for 10 minutes. They were randomly divided into 4 groups (n=6 based on the bonding agent used: Group P: Prime&Bond, Group O: One Step, Group S: Single Bond and Group E: Excite. Each group was prepared according to the manufacturer’s instructions. For all posts, a flowable composite core (ÆliteFlo, Bisco, USA were built-up over the bonded area. Each specimen was sectioned to produce 2 sticks, 1mm in thickness and underwent microtensile bond strength (µTBS. Data were analyzed using one-way ANOVA at the 0.05 level. The fractured surfaces of all sticks were evaluated by stereomicroscope (× 20. SEM assessment of two sticks from each group was performed to evaluate the surface morphology. Results: The means and SDs of µTBS were: Group P: 10.95±1.74; Group S: 10.25±2.39; Group E: 9.52±2.07; and Group O: 9.12±1.34. There was no statistic means and SDs ally significant difference in bond strength means between the groups used (p> 0.05. Conclusion: The results of this study indicated the bonding agents used had no significant influence on the bond strength of fiber post to composite core.

  10. An In vitro Evaluation of the Effect of Four Dentin Bonding System on the Bond Strength between Quartz Fiber Post and Composite Core.

    Science.gov (United States)

    Shirinzad, M; Ebadi, Sh; Shokripour, M; Darabi, Ma

    2014-03-01

    A strong bond of fiber post to resin core, as well as to dentin would critically ensure the durability of restorations in endodontically treated teeth. The purpose of this study was to evaluate the effect of etch-and-rinse dentin bonding systems on the bond strength between resin core and fiber post after application of 24% hydrogen peroxide.  24 fiber posts (RTD; St. Egèven, France) were treated with 24% hydrogen peroxide for 10 minutes. They were randomly divided into 4 groups (n=6) based on the bonding agent used: Group P: Prime&Bond, Group O: One Step, Group S: Single Bond and Group E: Excite. Each group was prepared according to the manufacturer's instructions. For all posts, a flowable composite core (ÆliteFlo; Bisco, USA) was built-up over the bonded area. Each specimen was sectioned to produce 2 sticks, 1mm in thickness and underwent microtensile bond strength (µTBS). Data were analyzed using one-way ANOVA at the 0.05 level. The fractured surfaces of all sticks were evaluated by stereomicroscope (× 20). Scanning electron microscopy(SEM) assessment of two sticks from each group was performed to evaluate the surface morphology. The means and SDs of µTBS were: Group P: 10.95±1.74; Group S: 10.25±2.39; Group E: 9.52±2.07; and Group O: 9.12±1.34. There was no statistically significant difference in bond strength means between the groups tested (p> 0.05).   The results of this study indicated the bonding agents used had no significant influence on the bond strength of fiber post to composite core.

  11. Evaluation of cyclosporine A eye penetration after administration of liposomal or conventional forms in animal model

    Directory of Open Access Journals (Sweden)

    Bizhan Malaekeh-Nikouei

    2013-01-01

    Full Text Available Abstract A lot of researches have investigated the effects of topical cyclosporine A on the eye surface layers’ diseases. By now the main limitation in cyclosporine application is the low permeation of the drug into the posterior segments of the eye. The aim of present study was to formulate high permeable dosage form can be beneficial in the topical treatment of the uveitis. To reach higher corneal drug absorption and drug concentration in the posterior segments of the eye, 3 nanoliposomal formulations containing 0.5 mg/ml cyclosporine A were prepared. Liposomal formulations and the commercial product (Restasis® were instilled in the right and left eyes of the rabbits, respectively. The rabbits were killed in the 3, 7, 14 and 28 days of study and the aqueous humor and vitreous were extracted. Mean size of liposomal formulation number 1, number 2 and number 3 were 107.2 ± 0.7, 129.3±0.9 and 144.8±1.8 nm and their zeta potential were -5.0±1.7, -5.5±2.3 and 44.6±6.2 mV, respectively. Results of ocular analysis showed that the liposomal formulations could increase the concentration of the drug in the aqueous and vitreous like Restasis®. But, in contrast with what has been expected the findings of this study implicate nanoliposomal formulations prepared could not make a significant difference in concentration of the drug in aqueous and vitreous humor compared to Restasis® (anionic microemulsion. In conclusion, we can state that liposomes with the same composition as our formulations are not more efficient than microemulsion for cyclosporine as ophthalmic drug delivery.

  12. Evaluation of cyclosporine A eye penetration after administration of liposomal or conventional forms in animal model

    Directory of Open Access Journals (Sweden)

    Sara Nikoofal-Sahlabadi

    2013-01-01

    Full Text Available Abstract A lot of researches have investigated the effects of topical cyclosporine A on the eye surface layers’ diseases. By now the main limitation in cyclosporine application is the low permeation of the drug into the posterior segments of the eye. The aim of present study was to formulate high permeable dosage form can be beneficial in the topical treatment of the uveitis. To reach higher corneal drug absorption and drug concentration in the posterior segments of the eye, 3 nanoliposomal formulations containing 0.5 mg/ml cyclosporine A were prepared. Liposomal formulations and the commercial product (Restasis® were instilled in the right and left eyes of the rabbits, respectively. The rabbits were killed in the 3, 7, 14 and 28 days of study and the aqueous humor and vitreous were extracted. Mean size of liposomal formulation number 1, number 2 and number 3 were 107.2 ± 0.7, 129.3±0.9 and 144.8±1.8 nm and their zeta potential were -5.0±1.7, -5.5±2.3 and 44.6±6.2 mV, respectively. Results of ocular analysis showed that the liposomal formulations could increase the concentration of the drug in the aqueous and vitreous like Restasis®. But, in contrast with what has been expected the findings of this study implicate nanoliposomal formulations prepared could not make a significant difference in concentration of the drug in aqueous and vitreous humor compared to Restasis® (anionic microemulsion. In conclusion, we can state that liposomes with the same composition as our formulations are not more efficient than microemulsion for cyclosporine as ophthalmic drug delivery.

  13. Aldosterone synthase gene polymorphism in alimentary obesity, metabolic syndrome components, some secondary forms of arterial hypertension, pathology of the adrenals glands core (literature review

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    S.N. Koval

    2017-10-01

    Full Text Available Hormonal factors of adrenal origin belong to the pathophysiological mechanisms of the formation and progression of arterial hypertension (AH and should be consi­dered while developing differentiated approaches to the treatment and prevention of hypertensive states, their primary, secondary and resistant forms. The first thing we should point up is aldosterone (AL, enzyme aldosterone synthase (AS, which takes a direct part in the formation of this hormone, as well as gene polymorphisms of AS, which have not only molecular genetic, but also differential diagnostic and therapeutic significance for secondary forms of arterial hypertension, abdominal obesity (AO, metabolic syndrome (MS, adrenal pathology and other endocrine disorders. AL is a steroid (mineralocorticoid hormone of the adrenal cortex, which is synthesized from cholesterol (CH, mainly in the glomerular zone of the adrenal glands, is released under the action of angiotensin II (A II and potassium ions (K+. AL acti­vity is mediated through the corresponding mineralocorticoid receptors (MKR. The particular importance in AH and MS development belongs to AL activation and MKR density in adipocytes, this phenomenon is accompanied by increased expression of pro-inflammatory cytokines, leptin, an adipogenic effect, and the inhibition of MCR activity is accompanied by increased production of adiponectin, which is more pronounced in patients with AH. Aldosterone synthase, a mitochondrial human enzyme encoded by the CYP11B2 gene (cytochrome P450, family 11, subfamily B, polypeptide 2 is located on the 8th chromosome. AS belongs to the superfamily of cytochrome P450 and regulates the synthesis of AL hormone. The CYP11B2 gene encodes the key enzyme for the synthesis of AL 18-hydroxylase. In scientific papers, single nucleotide polymorphism (SNP of AS gene is often studied, such as 5312T, Intron 2, Lys-173/Arg; T-344C, 3097 C/A. 227 SNP of the AS gene were identified in different

  14. FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN

    Directory of Open Access Journals (Sweden)

    Guru Sharan

    2012-01-01

    Full Text Available Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, irritable bowel syndrome but also for the potential it holds for the systemic delivery of proteins and therapeutic peptides. The aim of the study was to develop colon targeted film coated tablets of Ibuprofen using HPMC K4M, Eudragit L100, and Ethyl cellulose as carriers. All the formulations (F1 to F6 were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The amount of Ibuprofen released from tablets atdifferent time intervals was estimated by UV spectrophotometer. The formulation F6 released 98.34 % of Ibuprofen. The results of the study showed that formulation F6 is most likely to provide targeting of Ibuprofen for local action in the colon owing to its minimal release of the drug in the first 5 h. The results of the presentstudy have demonstrated that the film coated tablet system is a promising vehicle for preventing rapid hydrolysis in gastric environment and improving oral bioavailability of Ibuprofen for the treatment of disease of colon region.

  15. Pharmacokinetic evaluation of a new oral sustained release dosage form of tramadol

    Science.gov (United States)

    Malonne, H; Sonet, B; Streel, B; Lebrun, S; De Niet, S; Sereno, A; Vanderbist, F

    2004-01-01

    Aims To compare the pharmacokinetic profile of a new modified release formulation of tramadol (Tramadol LP 200 mg, SMB Technology, Marche-en-Famenne, Belgium) with that of an immediate release capsule (Topalgic® 50 mg, Grünenthal, Aachen, Germany) after single and multiple dosing and to assess the potential effect of food on its relative bioavailability. Methods The first study had an open, single-dose, three-treatment, three-period, six-sequence, randomised, crossover design with at least a five-day wash-out. The second study had an open, steady-state, two-treatment, two-period, two-sequence, randomised crossover design with at least a seven-day wash-out. Both studies contained 30 healthy subjects. Both enantiomers of tramadol and O-demethyl-tramadol (the only active metabolite of tramadol) were assayed in the plasma using an LC-MS/MS method. AUC∞, AUCt, Cmax, Tmax, and T1/2 were estimated. Statistical analysis was performed using univariate anova, the Wilcoxon nonparametric method or Friedman's nonparametric anova where appropriate. Results Tramadol had a significantly lower Cmax and longer Tmax than the conventional formulation. Thus, the mean (± sd) Cmax of tramadol were 646 ± 192 and 300 ± 94 ng ml−1 for Topalgic® 4 × 50mg and Tramadol LP 200 mg, respectively (95% confidence interval on the difference expressed as a percentage 42–51). AUC of tramadol from both formulations was comparable (similar AUC∞ and AUCt). Thus, the mean AUC∞ of (+/–)tramadol obtained after multiple dosing were 4611 ± 1944 and 5105 ± 2101 ngh ml−1 after Topalgic® 4 × 50mg and Tramadol LP 200 mg, respectively (95%CI 102–123%). We also demonstrate that the pharmacokinetics of the drug are not influenced by the intake of food. Thus, the mean AUC∞ of (+/–) tramadol were 5444 ± 1637 and 5169 ± 1580 ngh ml−1 after Tramadol LP 200 mg given in the fasting and fed states, respectively (95%CI = 88–103%). Conclusions The new sustained release form of tramadol

  16. Composite hollow core vaults: An analysis of the Fusée Céramic System and the design of form-active environmental friendly roofs

    Directory of Open Access Journals (Sweden)

    Wim Kamerling

    2016-03-01

    Full Text Available Just after World-War II building materials were scarce, architects and engineers had to design buildings using not much cement and steel. In French an architect, Jacques Couëlle, had invented a system with céramique infill elements to reduce for structures of concrete the self-weight and need of cement and steel. In the fifties and sixties of the twentieth century these céramique elements, known as Fusée Céramique elements, were used widely in France, North Africa and the Netherlands, mostly for barrel vaults and shells. Nowadays most of these structures are pulled down and the remaining buildings do not meet the demands of the present concerning climate comfort, insulation and safety.This thesis analyses the structural design of cylindrical Fusée Céramique roofs in the context of those days. The effect of the céramique infill elements for the time dependent deformations, stiffness and load bearing capacity, including second order, is studied. To save the few remaining buildings for the coming generations the possibilities to strengthen these structures with slender light elements of steel are explored. The effect of the strengthening is described for a Fusée Céramique vault, designed and constructed in the past.Reinforced concrete is a widely used building material with many advantages. Unfortunately the production of both reinforcement and cement is quite energy intensive and causes the emission of greenhouse gasses as NO2, NO and CO2. Reducing the need of cement is a relative simple way to reduce the emission of these greenhouse gasses.In practice roofs are seldom really flat but curved or at least slightly inclined, to drain rainwater and snow. Structurally curved structures, transferring loads as a surface-active or form-active structural system, are very efficient. The need of material and the self-weight is pretty low. This can be very useful if in the future the potentials of roofs for producing food and energy are used more

  17. [Evaluation of the efficacy and the limitation of ultrasound-guided core-needle biopsy, core-needle aspiration and fine-needle aspiration in micro-nodules of thyroid].

    Science.gov (United States)

    Zhang, Shaohang; Niu, Lijuan

    2014-11-01

    To evaluate the efficacy and the limitation of ultrasound-guided core-needle biopsy, ultrasound-guided core-needle aspiration and ultrasound-guided fine-needle aspiration in micro-nodules of thyroid. A retrospective was performed in 92 patients with suspectable malignent micro-nodules in thyroid. Of them, 52 patients underwent US-CNB and US-FNA and 40 patients underwent US-CNA and US-FNA. The diagnoses for the micro-nodules were identified by histopathlogical examination after surgery. Among 52 cases with both US-CNB and US-FNA, 41 got nondiagnostic US-CNB and 11 cases successfully got the correct diagnoses of US-CNB; 6 cases got the incorrect diagnosis of US-FNA and 46 cases got the correct diagnosis of US-FNA. Of 40 cases with US-CNA and US-FNA, unsatisfactory specimen of US-CNA occurred in 14 cases and satisfactory specimen of US-CNA were got in 26 cases; unsatisfactory specimen of US-FNA occurred in 4 cases and satisfactory specimen of US-FNA. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of US-FNA in 92 cases for the diagnosis of malignancy were 93.4%, 86.7%, 97.3%, 72.2% and 92.3%, respectively. US-FNA is the most valuable method for the diagnosis of suspectable malignent micro-nodules in thyroid before operation.

  18. Thermohydraulics of LMFBR core catchers

    Science.gov (United States)

    Turland, B. D.

    Characterization of the likely form of fuel debris after an accident, following interaction with sodium in the primary vessel and mechanisms controlling the location of the debris in the primary system is discussed. Heat transfer from particulate to liquid sodium and the development of models predicting the amount of debris that may be retained in a coolable form on a structure are considered. The evaluation of the coolability of the structure itself in post accident conditions, particularly the cooling provided by natural convection alone is treated. The response of structures at elevated temperatures and under high thermal loads is considered. The potential for vessel failure if significant quantities of debris accumulate at the bottom of the vessel is shown. The performance of a flat plate core catcher, or similar structure with good cooling from underneath is evaluated.

  19. Mars' core and magnetism.

    Science.gov (United States)

    Stevenson, D J

    2001-07-12

    The detection of strongly magnetized ancient crust on Mars is one of the most surprising outcomes of recent Mars exploration, and provides important insight about the history and nature of the martian core. The iron-rich core probably formed during the hot accretion of Mars approximately 4.5 billion years ago and subsequently cooled at a rate dictated by the overlying mantle. A core dynamo operated much like Earth's current dynamo, but was probably limited in duration to several hundred million years. The early demise of the dynamo could have arisen through a change in the cooling rate of the mantle, or even a switch in convective style that led to mantle heating. Presently, Mars probably has a liquid, conductive outer core and might have a solid inner core like Earth.

  20. Evaluation and identification of histamine-forming bacteria on fish products of middle Adriatic Sea

    Directory of Open Access Journals (Sweden)

    Claudia Costanza

    2013-04-01

    evaluate specific performance objectives, define useful parameters to qualify suppliers, and guarantee microbiological criteria fixed by Regulation EU 2073/2005.

  1. Expression of core antigen of HCV genotype 3a and its evaluation as screening agent for HCV infection in Pakistan

    Directory of Open Access Journals (Sweden)

    Rehman Irshad U

    2011-07-01

    Full Text Available Abstract Background Pakistan is facing a threat from hepatitis C infection which is increasing at an alarming rate throughout the country. More specific and sensitive screening assays are needed to timely and correctly diagnose this infection. Methods After RNA extraction from specimen (HCV-3a, cDNA was synthesized that was used to amplify full length core gene of HCV 3a. After verification through PCR, DNA sequencing and BLAST, a properly oriented positive recombinant plasmid for core gene was digested with proper restriction enzymes to release the target gene which was then inserted downstream of GST encoding DNA in the same open reading frame at proper restriction sites in multiple cloning site of pGEX4t2 expression vector. Recombinant expression vector for each gene was transformed in E. coli BL21 (DE3 and induced with IPTG for recombinant fusion protein production that was then purified through affinity chromatography. Western blot and Enzyme Linked Immunosorbant Assay (ELISA were used to detect immuno-reactivity of the recombinant protein. Results The HCV core antigen produced in prokaryotic expression system was reactive and used to develop a screening assay. After validating the positivity (100% and negativity (100% of in-house anti-HCV screening assay through a standardized panel of 200 HCV positive and 200 HCV negative sera, a group of 120 serum specimens of suspected HCV infection were subjected to comparative analysis of our method with commercially available assay. The comparison confirmed that our method is more specific than the commercially available assays for HCV strains circulating in this specific geographical region of the world and could thus be used for HCV screening in Pakistan. Conclusion In this study, we devised a screening assay after successful PCR amplification, isolation, sequencing, expression and purification of core antigen of HCV genotype 3a. Our developed screening assay is more sensitive, specific and

  2. Analysis of resin-dentin interface morphology and bond strength evaluation of core materials for one stage post-endodontic restorations.

    Directory of Open Access Journals (Sweden)

    Kerstin Bitter

    Full Text Available PURPOSE: Restoration of endodontically treated teeth using fiber posts in a one-stage procedure gains more popularity and aims to create a secondary monoblock. Data of detailed analyses of so called "post-and-core-systems" with respect to morphological characteristics of the resin-dentin interface in combination with bond strength measurements of fiber posts luted with these materials are scarce. The present study aimed to analyze four different post-and-core-systems with two different adhesive approaches (self-etch and etch-and-rinse. MATERIALS AND METHODS: Human anterior teeth (n = 80 were endodontically treated and post space preparations and post placement were performed using the following systems: Rebilda Post/Rebilda DC/Futurabond DC (Voco (RB, Luxapost/Luxacore Z/Luxabond Prebond and Luxabond A+B (DMG (LC, X Post/Core X Flow/XP Bond and Self Cure Activator (Dentsply DeTrey (CX, FRC Postec/MultiCore Flow/AdheSE DC (Ivoclar Vivadent (MC. Adhesive systems and core materials of 10 specimens per group were labeled using fluorescent dyes and resin-dentin interfaces were analyzed using Confocal Laser Scanning Microscopy (CLSM. Bond strengths were evaluated using a push-out test. Data were analyzed using repeated measurement ANOVA and following post-hoc test. RESULTS: CLSM analyses revealed significant differences between groups with respect to the factors hybrid layer thickness (p<0.0005 and number of resin tags (p = 0.02; ANOVA. Bond strength was significantly affected by core material (p = 0.001, location inside the root canal (p<0.0005 and incorporation of fluorescent dyes (p = 0.036; ANOVA. CX [7.7 (4.4 MPa] demonstrated significantly lower bond strength compared to LC [14.2 (8.7 MPa] and RB [13.3 (3.7 MPa] (p<0.05; Tukey HSD but did not differ significantly from MC [11.5 (3.5 MPa]. CONCLUSION: It can be concluded that bond strengths inside the root canal were not affected by the adhesive approach of the post-and-core-system. All systems

  3. Development and experimental validation of a calculation scheme for nuclear heating evaluation in the core of the OSIRIS material testing reactor

    Energy Technology Data Exchange (ETDEWEB)

    Malouch, F. [Saclay Center CEA, DEN/DANS/DM2S/SERMA, F-91191 Gif-sur-Yvette Cedex (France)

    2011-07-01

    The control of the temperature in material samples irradiated in a material testing reactor requires the knowledge of the nuclear heating caused by the energy deposition by neutrons and photons interacting in the irradiation device structures. Thus, a neutron-photonic three-dimensional calculation scheme has been developed to evaluate the nuclear heating in experimental devices irradiated in the core of the OSIRIS MTR reactor (CEA/Saclay Center). The aim is to obtain a predictive tool for the nuclear heating estimation in irradiation devices. This calculation scheme is mainly based on the TRIPOLI-4 three-dimensional continuous-energy Monte Carlo transport code, developed by CEA (Saclay Center). An experimental validation has been carried out on the basis of nuclear heating measurements performed in the OSIRIS core. After an overview of the experimental devices irradiated in the OSIRIS reactor, we present the calculation scheme and the first results of the experimental validation. (authors)

  4. Development and in vitro evaluation of core-shell type lipid-polymer hybrid nanoparticles for the delivery of erlotinib in non-small cell lung cancer.

    Science.gov (United States)

    Mandal, Bivash; Mittal, Nivesh K; Balabathula, Pavan; Thoma, Laura A; Wood, George C

    2016-01-01

    Core-shell type lipid-polymer hybrid nanoparticles (CSLPHNPs) have emerged as a multifunctional drug delivery platform. The delivery system combines mechanical advantages of polymeric core and biomimetic advantages of the phospholipid shell into a single platform. We report the development of CSLPHNPs composed of the lipid monolayer shell and the biodegradable polymeric core for the delivery of erlotinib, an anticancer drug, clinically used to treat non-small cell lung cancer (NSCLC). Erlotinib loaded CSLPHNPs were prepared by previously reported single-step sonication method using polycaprolactone (PCL) as the biodegradable polymeric core and phospholipid-shell composed of hydrogenated soy phosphatidylcholine (HSPC) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (DSPE-PEG2000). Erlotinib loaded CSLPHNPs were characterized for physicochemical properties including mean particle size, polydispersity index (PDI), zeta potential, morphology, thermal and infrared spectral analysis, drug loading, in vitro drug release, in vitro serum stability, and storage stability. The effect of critical formulation and process variables on two critical quality attributes (mean particle size and drug entrapment efficiency) of erlotinib loaded CSLPHNPs was studied and optimized. In addition, in vitro cellular uptake, luminescent cell viability assay and colony formation assay were performed to evaluate efficacy of erlotinib loaded CSLPHNPs in A549 cells, a human lung adenocarcinoma cell line. Optimized erlotinib loaded CSLPHNPs were prepared with mean particle size of about 170nm, PDI<0.2, drug entrapment efficiency of about 66% with good serum and storage stability. The evaluation of in vitro cellular efficacy results indicated enhanced uptake and efficacy of erlotinib loaded CSLPHNPs compared to erlotinib solution in A549 cells. Therefore, CSLPHNPs could be a potential delivery system for erlotinib in the therapy of NSCLC.

  5. The Research of Multi-Core Parallel Program Evaluation%多核并行程序评测相关技术研究

    Institute of Scientific and Technical Information of China (English)

    龚溪东

    2011-01-01

    On the occasion of competing, Multi-Core parallel program evaluation can get more satisfying efficiency while the accuracy of results can also be guaranteed comparing to the traditional single-process program evaluation. It is the machine itself, considering the hardware environment and current system load status, that dynamically decide whether to release a child process in process pool to participate in the program evaluation process in order to take full advantage of multi-core computing resources and improve the evaluation efficiency.%在竞赛场合下,多核并行程序评测技术是在保证程序评测结果满足既定准确度的前提下,对传统单进程程序评测技术的一种改进。它综合考虑机器本身的硬件环境以及系统当前负载状态对评测结果可能的影响,动态决定是否释放进程池中子进程参与到程序评测过程,在保证准确度的情况下,充分利用多核计算资源,提升评测效率。

  6. Mercury's core evolution

    Science.gov (United States)

    Deproost, Marie-Hélène; Rivoldini, Attilio; Van Hoolst, Tim

    2016-10-01

    Remote sensing data of Mercury's surface by MESSENGER indicate that Mercury formed under reducing conditions. As a consequence, silicon is likely the main light element in the core together with a possible small fraction of sulfur. Compared to sulfur, which does almost not partition into solid iron at Mercury's core conditions and strongly decreases the melting temperature, silicon partitions almost equally well between solid and liquid iron and is not very effective at reducing the melting temperature of iron. Silicon as the major light element constituent instead of sulfur therefore implies a significantly higher core liquidus temperature and a decrease in the vigor of compositional convection generated by the release of light elements upon inner core formation.Due to the immiscibility in liquid Fe-Si-S at low pressure (below 15 GPa), the core might also not be homogeneous and consist of an inner S-poor Fe-Si core below a thinner Si-poor Fe-S layer. Here, we study the consequences of a silicon-rich core and the effect of the blanketing Fe-S layer on the thermal evolution of Mercury's core and on the generation of a magnetic field.

  7. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2010-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  8. Transformer core

    NARCIS (Netherlands)

    Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

    2008-01-01

    A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

  9. 第三方物流企业核心竞争力的模糊评价%Fuzzy Evaluation of Core Competitivity of TPL Enterprises

    Institute of Scientific and Technical Information of China (English)

    唐友明; 李明武

    2014-01-01

    在广泛借鉴国内外学者研究成果的基础上,针对第三方物流企业的特点,构建了第三方物流企业核心竞争力评价指标体系;继而运用模糊评价法对第三方物流企业竞争力进行了评价。%In this paper, on the basis of a general review of the findings of Chinese and foreign scholars and in view of the characteristics of the third party logistics enterprises, we built the evaluation index system of the core competitivity of the third party logistics enterprises and then proposed to use the fuzzy evaluation process to evaluate the competitivity of the third party logistics enterprises.

  10. Intrahepatic and hilar mass-forming cholangiocarcinoma: Qualitative and quantitative evaluation with diffusion-weighted MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Fattach, Hassan El, E-mail: hassangreenmed@gmail.com [Department of Abdominal Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 2 rue Ambroise Paré, 75010 Paris (France); Dohan, Anthony, E-mail: anthony.dohan@lrb.aphp.fr [Department of Abdominal Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 2 rue Ambroise Paré, 75010 Paris (France); Université Paris-Diderot, Sorbonne Paris Cité, 10 Avenue de Verdun, 75010 Paris (France); UMR INSERM 965-Paris 7 “Angiogenèse et recherche translationnelle”, 2 rue Amboise Paré, 75010 Paris (France); Guerrache, Youcef, E-mail: docyoucef05@yahoo.fr [Department of Abdominal Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 2 rue Ambroise Paré, 75010 Paris (France); Dautry, Raphael, E-mail: raphael.dautry@lrb.aphp.fr [Department of Abdominal Imaging, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 2 rue Ambroise Paré, 75010 Paris (France); Université Paris-Diderot, Sorbonne Paris Cité, 10 Avenue de Verdun, 75010 Paris (France); and others

    2015-08-15

    Highlights: • DW-MR imaging helps depicts all intrahepatic or hilar mass-forming cholangiocarcinomas. • DW-MRI provides best conspicuity of intrahepatic or hilar mass-forming cholangiocarcinomas than the other MRI sequences (P < 0.001). • The use of normalized ADC using the liver as reference organ results in the most restricted distribution of ADC values of intrahepatic or hilar mass-forming cholangiocarcinomas (variation coefficient = 16.6%). - Abstract: Objective: To qualitatively and quantitatively analyze the presentation of intrahepatic and hilar mass-forming cholangiocarcinoma with diffusion-weighted magnetic resonance imaging (DW-MRI). Materials and methods: Twenty-eight patients with histopathologically proven mass-forming cholangiocarcinoma (hilar, n = 17; intrahepatic, n = 11) underwent hepatic DW-MRI at 1.5-T using free-breathing acquisition and three b-values (0,400,800 s/mm{sup 2}). Cholangiocarcinomas were evaluated qualitatively using visual analysis of DW-MR images and quantitatively with conventional ADC and normalized ADC measurements using liver and spleen as reference organs. Results: All cholangiocarcinomas (28/28; 100%) were visible on DW-MR images. DW-MRI yielded best conspicuity of cholangiocarcinomas than the other MRI sequences (P < 0.001). Seven cholangiocarcinomas (7/11; 64%) showed hypointense central area on DW-MR images. Conventional ADC value of cholangiocarcinomas (1.042 × 10{sup −3} mm{sup 2}/s ± 0.221 × 10{sup −3} mm{sup 2}/s; range: 0.616 × 10{sup −3} mm{sup 2}/s to 2.050 × 10{sup −3} mm{sup 2}/s) was significantly lower than that of apparently normal hepatic parenchyma (1.362 × 10{sup −3} mm{sup 2}/s ± 0.187 × 10{sup −3} mm{sup 2}/s) (P < 0.0001), although substantial overlap was found. No significant differences in ADC and normalized ADC values were found between intrahepatic and hilar cholangiocarcinomas. The use of normalized ADC using the liver as reference organ resulted in the most restricted

  11. Exploration of Relationship Between Core Self-evaluation and Depression%核心自我评价与抑郁关系的探讨

    Institute of Scientific and Technical Information of China (English)

    杨槐; 陈奕

    2012-01-01

    The exploration of relationship between core self-evaluation and depression will help find a right way to treat depression.This paper is to analyze the relationship between depression and core-evaluation proposed by Judge,respectively discuss the relationship between self-esteem;locus of control;generalized self-efficacy;emotional stability/low neuroticism and depression.It is theoretically found that depression is closely related to the core self-evaluation with a certain complexity to some extent.So a further empirical research would be taken.%对核心自我评价与抑郁关系的探讨有利于为抑郁情绪找到恰当的调节方法,也有利于为抑郁症找到科学治疗方法。文章以埃丽丝的ABC的理论为逻辑起点,从核心自我评价的四个方面,自尊、心理控制源、自我效能感、神经质,分别探讨了与抑郁的关系,发现核心自我评价四个方面与抑郁均存在显著的相关关系,从而推断核心自我评价与抑郁也具有显著的相关关系,但具有一定的复杂性,具体作用机制还不清楚,有待于进步实证研究。

  12. Injectable in situ forming drug delivery system for cancer chemotherapy using a novel tissue adhesive: characterization and in vitro evaluation.

    Science.gov (United States)

    Kakinoki, Sachiro; Taguchi, Tetsushi; Saito, Hirofumi; Tanaka, Junzo; Tateishi, Tetsuya

    2007-06-01

    Injectable polymers that are biocompatible and biodegradable are important biomaterials for drug delivery system (DDS) and tissue engineering. We have already developed novel tissue adhesives consisting of biomacromolecules and organic acid derivatives with active ester groups. The resulting tissue adhesive forms in situ as a gel and has high bonding strength for living tissue as well as it has good biocompatibility and biodegradability. Here, we report on the physicochemical properties and in vitro evaluation of this novel tissue adhesive consisting of human serum albumin (HSA) and tartaric acid derivative (TAD) containing doxorubicin hydrochloride (DOX). The results of the measurement of physicochemical characteristics indicate that the gelation time and gel strength of HSA-TAD gels can be controlled according to the material composition. The bonding strength of HSA-TAD adhesives was found to be sufficient to adhere at focus and to correspond with the cross-linking density of HSA-TAD gels. Furthermore, the release of DOX from HSA-TAD gels was sustained for approximately 100 h in an in vitro evaluation. The novel tissue adhesive, therefore, is expected to be applicable for use as an injectable in situ forming DDS.

  13. Physicochemical and in vitro biocompatibility evaluation of water-soluble CdSe/ZnS core/shell.

    Science.gov (United States)

    Painuly, Diksha; Bhatt, Anugya; Krishnan, Venkiteswaran Kalliyana

    2014-04-01

    Group II-VI semiconductor quantum dots (Q-dots) have found various applications in biomedical field during last decade. In this study, we have synthesized CdSe Q-dots and CdSe/ZnS core/shell (CS) by wet chemical route and characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier-transform infrared spectroscopy (FT-IR) and Photoluminescence (PL) spectroscopy. CS formation was confirmed by red shift as well as enhancement in the luminescence peak compared to bare Q-dots. Processing parameters such as core and sulfur concentrations were optimized at maximum luminescence efficiency during the shell preparation. Effects of dialysis, aging and cell culture medium on the properties of the Q-dots and CS were also studied by luminescence and DLS techniques. DLS data showed Q-dots and CS to be stable, and there was no effect on the integrity of the Q-dots and CS after various modifications. CS was found to be hemocompatible and cytocompatible for human umbilical vein endothelial cells even at a high concentration of 0.1 mg/ml up to 48 h indicating high potential for CS in various biomedical applications.

  14. The evaluation of kefir pure culture starter: Liquid-core capsule entrapping microorganisms isolated from kefir grains.

    Science.gov (United States)

    Wang, Liang; Zhong, Hao; Liu, Keying; Guo, Aizhen; Qi, Xianghui; Cai, Meihong

    2016-10-01

    The main purpose of this study was to develop a pure culture starter for producing kefir. In order to accomplish starter recycling, yeasts (Kluyveromyces marxianus strain, Pichia kudriavzevii clone), lactic acid bacteria (Lactobacillus kefiri strain F4Aa, Lactobacillus kefiri strain NM131-7, Lactobacillus kefiri strain NM132-3, Lactobacillus kefiri strain NM180-3, respectively), and acetic acid bacteria (Acetobacter lovaniensis strain) were entrapped in liquid core capsules based on the distribution ratio in kefir grains. The microbiological, antimicrobial, and chemical properties of kefir made with capsules (M) and kefir grains (K) were measured and compared. According to the results of plate counts in different selective medium, the number of yeasts and bacteria in the liquid core capsules gradually increased and stabilized after eight fermentation cycles. The results of gas chromatography-mass spectrometry showed that almost all the aroma components existed in the two type of kefir, except the ethyl lactate. There was no significant difference in alcohol content, protein content, and fat content, except the acidity and sugar content. Water holding capacity of kefir K was higher than kefir M. There were 14 same free amino acids in kefir M and kefir K, and the content of most free amino acids was similar. In antimicrobial test, there was no significant difference in both kefirs. © The Author(s) 2016.

  15. Field calibration of soil-core microcosms for evaluating fate and effects of genetically engineered microorganisms in terrestrial ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    Bolton, H Jr; Fredrickson, J K; Bentjen, S A; Workman, D J; Li, S W; Thomas, J M

    1991-04-01

    Pacific Northwest Laboratory compared intact soil-core microcosms and the field for ecosystem structural and functional properties after the introduction of a model genetically engineered microorganism (GEM). This project used two distinct microbial types as model GEMs, Gram-negative Pseudomonas sp. RC1, which was an aggressive root colonizer, and Gram-positive Streptomyces lividans TK24. The model GEMs were added to surface soil in separate studies, with RC1 studied throughout the growth of winter wheat (Triticum aestivum), while TK24 was studied throughout a ten month period. Also, RC1 was used in studies conducted during two consecutive field seasons (1988 to 1990) to determine how year-to-year field variability influenced the calibration of microcosms with the field. The main conclusions of this research were that intact soil-core microcosms can be useful to simulate the field for studies of microbial fate and effects on ecosystem structural and functional properties. In general, microcosms in the growth chamber, which simulated average field variations, were similar to the field for most parameters or differences could be attributed to the great extremes in temperature that occurred in the field compared to the microcosms. Better controls of environmental variables including temperature and moisture will be necessary to more closely simulate the field for future use of microcosms for risk assessment. 126 refs., 13 figs., 12 tabs.

  16. Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.

    Science.gov (United States)

    Jiao, Guan-Sheng; Kim, Seongjin; Moayeri, Mahtab; Crown, Devorah; Thai, April; Cregar-Hernandez, Lynne; McKasson, Linda; Sankaran, Banumathi; Lehrer, Axel; Wong, Teri; Johns, Lisa; Margosiak, Stephen A; Leppla, Stephen H; Johnson, Alan T

    2012-03-15

    Four core structures capable of providing sub-nanomolar inhibitors of anthrax lethal factor (LF) were evaluated by comparing the potential for toxicity, physicochemical properties, in vitro ADME profiles, and relative efficacy in a rat lethal toxin (LT) model of LF intoxication. Poor efficacy in the rat LT model exhibited by the phenoxyacetic acid series (3) correlated with low rat microsome and plasma stability. Specific molecular interactions contributing to the high affinity of inhibitors with a secondary amine in the C2-side chain were revealed by X-ray crystallography.

  17. FY16 Annual Accomplishments - Waste Form Development and Performance: Evaluation Of Ceramic Waste Forms - Comparison Of Hot Isostatic Pressed And Melt Processed Fabrication Methods

    Energy Technology Data Exchange (ETDEWEB)

    Amoroso, J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Dandeneau, C. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-10-13

    FY16 efforts were focused on direct comparison of multi-phase ceramic waste forms produced via melt processing and HIP methods. Based on promising waste form compositions previously devised at SRNL, simulant material was prepared at SRNL and a portion was sent to the Australian Nuclear Science and Technology Organization (ANSTO) for HIP treatments, while the remainder of the material was melt processed at SRNL. The microstructure, phase formation, elemental speciation, and leach behavior, and radiation stability of the fabricated ceramics was performed. In addition, melt-processed ceramics designed with different fractions of hollandite, zirconolite, perovskite, and pyrochlore phases were investigated. for performance and properties.

  18. Performance Evaluation of the Concept of Hybrid Heat Pipe as Passive In-core Cooling Systems for Advanced Nuclear Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Yeong Shin; Kim, Kyung Mo; Kim, In Guk; Bang, In Cheol [UNIST, Ulsan (Korea, Republic of)

    2015-05-15

    As an arising issue for inherent safety of nuclear power plant, the concept of hybrid heat pipe as passive in-core cooling systems was introduced. Hybrid heat pipe has unique features that it is inserted in core directly to remove decay heat from nuclear fuel without any changes of structures of existing facilities of nuclear power plant, substituting conventional control rod. Hybrid heat pipe consists of metal cladding, working fluid, wick structure, and neutron absorber. Same with working principle of the heat pipe, heat is transported by phase change of working fluid inside metal cask. Figure 1 shows the systematic design of the hybrid heat pipe cooling system. In this study, the concept of a hybrid heat pipe was introduced as a Passive IN-core Cooling Systems (PINCs) and demonstrated for internal design features of heat pipe containing neutron absorber. Using a commercial CFD code, single hybrid heat pipe model was analyzed to evaluate thermal performance in designated operating condition. Also, 1-dimensional reactor transient analysis was done by calculating temperature change of the coolant inside reactor pressure vessel using MATLAB. As a passive decay heat removal device, hybrid heat pipe was suggested with a concept of combination of heat pipe and control rod. Hybrid heat pipe has distinct feature that it can be a unique solution to cool the reactor when depressurization process is impossible so that refueling water cannot be injected into RPV by conventional ECCS. It contains neutron absorber material inside heat pipe, so it can stop the reactor and at the same time, remove decay heat in core. For evaluating the concept of hybrid heat pipe, its thermal performance was analyzed using CFD and one-dimensional transient analysis. From single hybrid heat pipe simulation, the hybrid heat pipe can transport heat from the core inside to outside about 18.20 kW, and total thermal resistance of hybrid heat pipe is 0.015 .deg. C/W. Due to unique features of long heat

  19. Forming Core Elements for Strategic Design Management

    DEFF Research Database (Denmark)

    Beim, Anne; Vibæk, Kasper Sánchez

    2007-01-01

    Complexity arising from increasing globalization of the marketplace and computer-based communication and information technology seems to create a growing need for simplicity, control and reliability. At the same time, contemporary consumer culture calls for customized and personalized goods. This...

  20. Forming Process and Dynamic Evaluation of New Business Model%新商业模式成型过程与动态测评

    Institute of Scientific and Technical Information of China (English)

    李永发; 李东

    2015-01-01

    Important reasons w hy innovation of business model is hard to succeed lie in lack of understanding of business model's forming path .There are infinite evolution results in theory when a new business idea evolving into a new business model .As a mediated moderator ,business model adjusts the input variables (e .g .,technology ,risk investment ) ,affects the output variables (e .g .,corporate profits ,market capitalization ,user volume ,etc .) .At present ,the importance of business model for enterprises obtain broad consensus ,so the dynamic evaluation based on analyzing business model form‐ing process will promote actual evolution results of business model to move in the same direction with expected results . Forming of business model is divided into four stages :brewing ,experimental learning ,cultivating and duplicating ,and the corresponding key dynamic evaluation items are :customer value proposition ,core repeated standard activities ,profit model and matching betw een components .%商业模式创新难以获得成功的重要原因在于缺乏对商业模式成型路径的理解。一个新商业构想向新商业模式演化,在理论上存在无穷种结果。作为中介调节变量,商业模式能够调节输入变量(如技术、风险投资),影响输出变量(如企业利润、市值、用户数等)。对商业模式成型过程进行分析和动态测评,将促进商业模式实际演化结果与期望方向一致。商业模式成型被划分为4个阶段:酝酿、试验学习、培育与复制。与之对应的关键动态测评项目为:顾客价值主张、核心可重复的标准活动系统、盈利模式和组件间的匹配。

  1. Teaching Form as Form

    DEFF Research Database (Denmark)

    Keiding, Tina Bering

    2012-01-01

    understanding of form per se, or, to use an expression from this text, of form as form. This challenge can be reduced to one question: how can design teaching support students in achieving not only the ability to recognize and describe different form-related concepts in existing design (i.e. analytical...... means that form serves both as the connective value and as the concept for reflection. In other words, form is observed as form, not anything else. The didactical challenge of teaching form as form is accentuated by students’ everyday-based pre-orientation towards function at the expense of form....... In general, students enter design education as far more skilled observers with regards to function than form. They are, in other words, predisposed to observe objects asking ‘what is?’, rather than ‘how is?’. This habit has not only cognitive implications. It is closely intertwined with a rudimentary...

  2. Teaching Form as Form

    DEFF Research Database (Denmark)

    Keiding, Tina Bering

    2012-01-01

    understanding of form per se, or, to use an expression from this text, of form as form. This challenge can be reduced to one question: how can design teaching support students in achieving not only the ability to recognize and describe different form-related concepts in existing design (i.e. analytical...... means that form serves both as the connective value and as the concept for reflection. In other words, form is observed as form, not anything else. The didactical challenge of teaching form as form is accentuated by students’ everyday-based pre-orientation towards function at the expense of form...... vocabulary of form. Even in cases in which teaching uses terms and phrases from everyday life (for instance, ‘intersection’), the meaning of the word cannot necessarily be transmitted directly from an ordinary vocabulary into a design context. And it is clearly a common issue for the contributions...

  3. Using imagery perspective to access two distinct forms of self-knowledge: associative evaluations versus propositional self-beliefs.

    Science.gov (United States)

    Libby, Lisa K; Valenti, Greta; Hines, Karen A; Eibach, Richard P

    2014-04-01

    When mentally simulating life events, people may visualize them from either an actor's 1st-person or observer's 3rd-person visual perspective. Two experiments demonstrated that visual perspective differentially determines reliance on 2 distinct forms of self-knowledge: associative evaluations of the simulated environment and propositional self-beliefs about relevant values and preferences. Implicit measures indexed associative evaluations of environmental stimuli (political candidates, outgroups); explicit measures indexed propositional self-beliefs about relevant personal values or preferences. A separate session manipulated participants' visual perspective for mentally simulating a pertinent event (voting, interracial interaction) as they forecasted their behavior or feelings if that event occurred. Forecasts corresponded more closely with associative evaluations from the 1st-person than 3rd-person perspective but more closely with propositional self-beliefs from the 3rd-person than 1st-person. Results have practical implications for channeling the power of mental simulation to desired ends and theoretical implications for understanding the pathways by which imagery and mental simulation shape cognition.

  4. FY16 Annual Accomplishments - Waste Form Development and Performance: Evaluation Of Ceramic Waste Forms - Comparison Of Hot Isostatic Pressed And Melt Processed Fabrication Methods

    Energy Technology Data Exchange (ETDEWEB)

    Amoroso, J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Dandeneau, C. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-10-13

    FY16 efforts were focused on direct comparison of multi-phase ceramic waste forms produced via melt processing and HIP methods. Based on promising waste form compositions previously devised at SRNL[13], simulant material was prepared at SRNL and a portion was sent to the Australian Nuclear Science and Technology Organization (ANSTO) for HIP treatments, while the remainder of the material was melt processed at SRNL. The microstructure, phase formation, elemental speciation, and leach behavior, and radiation stability of the fabricated ceramics was performed. In addition, melt-processed ceramics designed with different fractions of hollandite, zirconolite, perovskite, and pyrochlore phases were investigated. for performance and properties. Table 1 lists the samples studied.

  5. Ice Cores

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Records of past temperature, precipitation, atmospheric trace gases, and other aspects of climate and environment derived from ice cores drilled on glaciers and ice...

  6. Core BPEL

    DEFF Research Database (Denmark)

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  7. Core BPEL

    DEFF Research Database (Denmark)

    Hallwyl, Tim; Højsgaard, Espen

    extensions. Combined with the fact that the language definition does not provide a formal semantics, it is an arduous task to work formally with the language (e.g. to give an implementation). In this paper we identify a core subset of the language, called Core BPEL, which has fewer and simpler constructs......, does not allow omissions, and does not contain ignorable elements. We do so by identifying syntactic sugar, including default values, and ignorable elements in WS-BPEL. The analysis results in a translation from the full language to the core subset. Thus, we reduce the effort needed for working...... formally with WS-BPEL, as one, without loss of generality, need only consider the much simpler Core BPEL. This report may also be viewed as an addendum to the WS-BPEL standard specification, which clarifies the WS-BPEL syntax and presents the essential elements of the language in a more concise way...

  8. Core benefits

    National Research Council Canada - National Science Library

    Keith, Brian W

    2010-01-01

    This SPEC Kit explores the core employment benefits of retirement, and life, health, and other insurance -benefits that are typically decided by the parent institution and often have significant governmental regulation...

  9. Evaluation quantitative des produits formés lors de l'évolution géochimique de la matière organique Quantitative Evaluation of Products Formed During the Geochemical Evolution of Organic Matter

    Directory of Open Access Journals (Sweden)

    Pelet R.

    2006-11-01

    Full Text Available L'évaluation quantitative des produits mobiles formés lors de l'évolution géochimique de la matière organique est nécessaire parce qu'on ne peut jamais retrouver ces produits en place dans. la roche où ils ont pris naissance. Ils ont, en effet, pu migrer durant l'histoire géologique, et de toute manière une fraction, importante et non connue, se perd lors de la prise des échantillons puis de leur conservation avant analyse. La connaissance de l'analyse d'un état E et d'un état plus évolué E' ne suffit pas pour reconstituer les quantités de produits formés. La pyrolyse type Rock-Eval sur kérogènes, avec détermination du carbone résiduel, permet par contre, à partir d'une hypothèse raisonnable, de calculer les hydrocarbures produits. L'analyse élémentaire permet d'y ajouter CO2, H2O, H2S et N2 (considérés comme seuls produits à côté des hydrocarbures. Une analyse chromatographique sommaire supplémentaire permet d'estimer la composition globale des hydrocarbures. Dans le cas des roches, on propose des techniques de correction de l'effet de matrice pratiquement utilisables et qui permettent de retrouver les résultats précédents, au prix d'une incertitude accrue. The mobile products formed during the geochemical evolution of organic matter must be quantitatively evaluated because these products can never be found in place in the rock where they were formed. Indeed, they may have migrated during geological history, and in any case a large and unknown fraction gets lost when samples are taken and then stored before being analysed. Knowing the elemental analysis of a state E and of a more evolved state E' does not suffice for recreating the amounts of products formed. On the other hand Rock-Eval type pyrolysis of kerogens, including the determination of the residual carbon, can be used to compute the hydrocarbons produced, on the basis of a reasonable hypothesis. Elemental analysis then enables the evaluation of CO2, H2O

  10. Glass-Forming Ability of an Iron-Based Alloy Enhanced by Co Addition and Evaluated by a New Criterion

    Institute of Scientific and Technical Information of China (English)

    CHEN Qing-Jun; SHEN Jun; FAN Hong-Bo; SUN Jian-Fei; HUANG Yong-Jiang; MCCARTNEY D. G.

    2005-01-01

    @@ A new Fe-based alloy that can be cast into a fully amorphous rod with a diameter of at least 16mm by the conventional copper-mould casting technique is obtained by partially replacing Fe with Co in a previously reported Fe-based bulk metallic glass. The preliminary thermodynamic analysis indicates that the Co-containing alloy has a significantly lower Gibbs free energy difference between the undercooled melt and the corresponding crystalline solid, compared to the Co-free alloy, reflecting the dramatic role of the Co addition in stabilizing the supercooled melt and facilitating glass formation in iron-based alloys. Here, a new criterion, derived from the classical nucleation and growth theory, is introduced to evaluate the glass-forming ability of Fe-based bulk metallic glasses.

  11. [Evaluation of the tree form quality of middle-aged Pinus tabuliformis plantation under different canopy densities in Huanglong Mountains, Northwest China].

    Science.gov (United States)

    You, Jian-jian; Zhang, Wen-hui; Deng, Lei

    2015-07-01

    To clarify the effects of different canopy densities on tree form quality of Pinus tabuliformis, a hierarchical indicator system was structured, which brought about a set of grading criteria to evaluate tree form quality of the middle-aged P. tabuliformis plantation under four canopy densities in Huanglong Mountains by using the analytic hierarchy process (AHP). Plots were divided into four classes according to the stand canopy density (CD) : CDdiameter at breast height (DBH), tree height, diameter height ratio, taperingness, stem straightness, forking ratio, height under living branch, number of branches, max-branch base diameter and average base diameter of branches, the tree form quality could be evaluated. Among these factors, stem straightness, forking ratio and DBH were the most important ones influencing the tree form quality with a total weight of 0.7382. So, these three indicators were the major determinants of tree form quality. The comprehensive scores of the tree form quality evaluations fluctuated as the canopy density decreased and topped at 90.28 when CD was valued at 0.75 (type 2). The indicators and evaluation system developed in this study were easy to operate, and quite fit for solving the quantity problem of the tree form quality evaluation. Our system would be capable for applications in evaluating the tree form quality of other tree species on the Loess Plateau.

  12. Application of Core Dynamics Modeling to Core-Mantle Interactions

    Science.gov (United States)

    Kuang, Weijia

    2003-01-01

    Observations have demonstrated that length of day (LOD) variation on decadal time scales results from exchange of axial angular momentum between the solid mantle and the core. There are in general four core-mantle interaction mechanisms that couple the core and the mantle. Of which, three have been suggested likely the dominant coupling mechanism for the decadal core-mantle angular momentum exchange, namely, gravitational core-mantle coupling arising from density anomalies in the mantle and in the core (including the inner core), the electromagnetic coupling arising from Lorentz force in the electrically conducting lower mantle (e.g. D-layer), and the topographic coupling arising from non-hydrostatic pressure acting on the core-mantle boundary (CMB) topography. In the past decades, most effort has been on estimating the coupling torques from surface geomagnetic observations (kinematic approach), which has provided insights on the core dynamical processes. In the meantime, it also creates questions and concerns on approximations in the studies that may invalidate the corresponding conclusions. The most serious problem is perhaps the approximations that are inconsistent with dynamical processes in the core, such as inconsistencies between the core surface flow beneath the CMB and the CMB topography, and that between the D-layer electric conductivity and the approximations on toroidal field at the CMB. These inconsistencies can only be addressed with numerical core dynamics modeling. In the past few years, we applied our MoSST (Modular, Scalable, Self-consistent and Three-dimensional) core dynamics model to study core-mantle interactions together with geodynamo simulation, aiming at assessing the effect of the dynamical inconsistencies in the kinematic studies on core-mantle coupling torques. We focus on topographic and electromagnetic core-mantle couplings and find that, for the topographic coupling, the consistency between the core flow and the CMB topography is

  13. Structural characterization of the isoenzymatic forms of human myeloperoxidase: evaluation of the iron-containing prosthetic group.

    Science.gov (United States)

    Wright, J; Bastian, N; Davis, T A; Zuo, C; Yoshimoto, S; Orme-Johnson, W H; Tauber, A I

    1990-01-01

    Myeloperoxidase (MPO) from human neutrophils has been purified and found to exist in three isoenzymatic forms, resolved by ion exchange chromatography. In addition to differences in subunit size and cellular compartmentalization of the isoenzymes, differences have been reported in their activity and susceptibility to inhibition. The structural basis of these isoenzymes is unclear; we attempted to further define their functional characteristics and structural identity. First, we measured respective enzymatic activity using a panel of substrates; MPO I was found to have lower activity with some substrates (pyrogallol, guaiacol, potassium iodide [KI]), but similar activity to the other isoenzymes with 4-aminoantipyrine. These studies confirm that MPO I is enzymatically distinct from MPO II and MPO III. Next, we examined the structural basis of these differences by evaluating the iron-containing prosthetic group in each form using electron paramagnetic resonance (EPR) and determination of the pyridine hemochrome. No significant difference between the isoenzymes was noted in these parameters, suggesting that the prosthetic group is the same in each protein. The cause for any difference in enzymatic activity must lie then in variations extrinsic to the heme, and based on previous studies of the gene and protein analysis, the posttranslational modification of MPO must account for these isoenzymatic species.

  14. An Accelerated Release Study to Evaluate Long-Acting Contraceptive Levonorgestrel-Containing in Situ Forming Depot Systems.

    Science.gov (United States)

    Janagam, Dileep R; Wang, Lizhu; Ananthula, Suryatheja; Johnson, James R; Lowe, Tao L

    2016-09-01

    Biodegradable polymer-based injectable in situ forming depot (ISD) systems that solidify in the body to form a solid or semisolid reservoir are becoming increasingly attractive as an injectable dosage form for sustained (months to years) parenteral drug delivery. Evaluation of long-term drug release from the ISD systems during the formulation development is laborious and costly. An accelerated release method that can effectively correlate the months to years of long-term release in a short time such as days or weeks is economically needed. However, no such accelerated ISD system release method has been reported in the literature to date. The objective of the current study was to develop a short-term accelerated in vitro release method for contraceptive levonorgestrel (LNG)-containing ISD systems to screen formulations for more than 3-month contraception after a single subcutaneous injection. The LNG-containing ISD formulations were prepared by using biodegradable poly(lactide-co-glycolide) and polylactic acid polymer and solvent mixtures containing N-methyl-2-pyrrolidone and benzyl benzoate or triethyl citrate. Drug release studies were performed under real-time (long-term) conditions (PBS, pH 7.4, 37 °C) and four accelerated (short-term) conditions: (A) PBS, pH 7.4, 50 °C; (B) 25% ethanol in PBS, pH 7.4, 50 °C; (C) 25% ethanol in PBS, 2% Tween 20, pH 7.4, 50 °C; and (D) 25% ethanol in PBS, 2% Tween 20, pH 9, 50 °C. The LNG release profile, including the release mechanism under the accelerated condition D within two weeks, correlated (r² ≥ 0.98) well with that under real-time conditions at four months.

  15. An Accelerated Release Study to Evaluate Long-Acting Contraceptive Levonorgestrel-Containing in Situ Forming Depot Systems

    Directory of Open Access Journals (Sweden)

    Dileep R. Janagam

    2016-09-01

    Full Text Available Biodegradable polymer-based injectable in situ forming depot (ISD systems that solidify in the body to form a solid or semisolid reservoir are becoming increasingly attractive as an injectable dosage form for sustained (months to years parenteral drug delivery. Evaluation of long-term drug release from the ISD systems during the formulation development is laborious and costly. An accelerated release method that can effectively correlate the months to years of long-term release in a short time such as days or weeks is economically needed. However, no such accelerated ISD system release method has been reported in the literature to date. The objective of the current study was to develop a short-term accelerated in vitro release method for contraceptive levonorgestrel (LNG-containing ISD systems to screen formulations for more than 3-month contraception after a single subcutaneous injection. The LNG-containing ISD formulations were prepared by using biodegradable poly(lactide-co-glycolide and polylactic acid polymer and solvent mixtures containing N-methyl-2-pyrrolidone and benzyl benzoate or triethyl citrate. Drug release studies were performed under real-time (long-term conditions (PBS, pH 7.4, 37 °C and four accelerated (short-term conditions: (A PBS, pH 7.4, 50 °C; (B 25% ethanol in PBS, pH 7.4, 50 °C; (C 25% ethanol in PBS, 2% Tween 20, pH 7.4, 50 °C; and (D 25% ethanol in PBS, 2% Tween 20, pH 9, 50 °C. The LNG release profile, including the release mechanism under the accelerated condition D within two weeks, correlated (r2 ≥ 0.98 well with that under real-time conditions at four months.

  16. An Accelerated Release Study to Evaluate Long-Acting Contraceptive Levonorgestrel-Containing in Situ Forming Depot Systems

    Science.gov (United States)

    Janagam, Dileep R.; Wang, Lizhu; Ananthula, Suryatheja; Johnson, James R.; Lowe, Tao L.

    2016-01-01

    Biodegradable polymer-based injectable in situ forming depot (ISD) systems that solidify in the body to form a solid or semisolid reservoir are becoming increasingly attractive as an injectable dosage form for sustained (months to years) parenteral drug delivery. Evaluation of long-term drug release from the ISD systems during the formulation development is laborious and costly. An accelerated release method that can effectively correlate the months to years of long-term release in a short time such as days or weeks is economically needed. However, no such accelerated ISD system release method has been reported in the literature to date. The objective of the current study was to develop a short-term accelerated in vitro release method for contraceptive levonorgestrel (LNG)-containing ISD systems to screen formulations for more than 3-month contraception after a single subcutaneous injection. The LNG-containing ISD formulations were prepared by using biodegradable poly(lactide-co-glycolide) and polylactic acid polymer and solvent mixtures containing N-methyl-2-pyrrolidone and benzyl benzoate or triethyl citrate. Drug release studies were performed under real-time (long-term) conditions (PBS, pH 7.4, 37 °C) and four accelerated (short-term) conditions: (A) PBS, pH 7.4, 50 °C; (B) 25% ethanol in PBS, pH 7.4, 50 °C; (C) 25% ethanol in PBS, 2% Tween 20, pH 7.4, 50 °C; and (D) 25% ethanol in PBS, 2% Tween 20, pH 9, 50 °C. The LNG release profile, including the release mechanism under the accelerated condition D within two weeks, correlated (r2 ≥ 0.98) well with that under real-time conditions at four months. PMID:27598191

  17. Development of core design and analysis technology for integral reactor; development of coolant activity and dose evaluation program

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Chang Sun; Kim, Byeong Soo; Go, Hyun Seok; Lee, Young Wook; Jang, Mee [Seoul National University, Seoul (Korea)

    2002-03-01

    SMART, small- medium-sized integral reactor, is different from the customary electricity-generation PWR in design concepts and structures. The conventional coolant activity evaluation codes used in customary PWRs cannot be applied to SMART. In this study, SAEP(Specific Activity Evaluation Program) is developed that can be applied to both customary PWR and advanced reactor such as SMART. SAEP uses three methods(SAEP Ver.02, Ver.05, Ver.06) to evaluate coolant activity. They solve inhomogeneous linearly-coupled differential equations generated by considering nuclear system as N sub-components. Coolant activities of customary PWR are evaluated by use of SAEP. The results show good agreement with FSAR data. SAEP is used to evaluate coolant activities for SMART and the results are proposed in this study. These results show that SAEP is able to perform coolant activity evaluation for both customary PWR and advanced reactor such as SMART. In addition, with respect to radiation shielding optimization, conventional optimization methods and their characteristics related to radiation shielding are reviewed and analyzed. Strategies for proper usage of conventional methods are proposed to agree with the shielding design cases. 30 refs., 25 figs., 6 tabs. (Author)

  18. Development of core design and analysis technology for integral reactor; development of coolant activity and dose evaluation program

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Chang Sun; Kim, Byeong Soo; Go, Hyun Seok; Lee, Young Wook; Jang, Mee [Seoul National University, Seoul (Korea)

    2002-03-01

    SMART, small- medium-sized integral reactor, is different from the customary electricity-generation PWR in design concepts and structures. The conventional coolant activity evaluation codes used in customary PWRs cannot be applied to SMART. In this study, SAEP(Specific Activity Evaluation Program) is developed that can be applied to both customary PWR and advanced reactor such as SMART. SAEP uses three methods(SAEP Ver.02, Ver.05, Ver.06) to evaluate coolant activity. They solve inhomogeneous linearly-coupled differential equations generated by considering nuclear system as N sub-components. Coolant activities of customary PWR are evaluated by use of SAEP. The results show good agreement with FSAR data. SAEP is used to evaluate coolant activities for SMART and the results are proposed in this study. These results show that SAEP is able to perform coolant activity evaluation for both customary PWR and advanced reactor such as SMART. In addition, with respect to radiation shielding optimization, conventional optimization methods and their characteristics related to radiation shielding are reviewed and analyzed. Strategies for proper usage of conventional methods are proposed to agree with the shielding design cases. 30 refs., 25 figs., 6 tabs. (Author)

  19. Mentoring as an HRD Approach: Effects on Employee Attitudes and Contributions Independent of Core Self-Evaluation

    Science.gov (United States)

    Thurston, Paul W., Jr.; D'Abate, Caroline P.; Eddy, Erik R.

    2012-01-01

    Mentoring as a form of strategic human resource management is an interesting addition to the HRD literature because it provides a mechanism of change for individual employees. Numerous studies have demonstrated the benefits of mentoring to both the employee and the firm; yet, a recent review of mentoring research argues that mentoring has less…

  20. Ventral medial prefrontal cortex and person evaluation: forming impressions of others varying in financial and moral status.

    Science.gov (United States)

    Cloutier, Jasmin; Gyurovski, Ivo

    2014-10-15

    The current study investigated ventromedial prefrontal cortex (VMPFC) activity during impression formation of individuals varying on distinct dimensions of social status. In a block-design functional magnetic resonance imaging (fMRI) experiment, participants were presented with photographs of faces paired with a colored background indicating their lower, same, or higher financial status, or lower, same, or higher moral status. Participants were asked to form an impression of the targets, but were not instructed to explicitly evaluate them based on social status. Building on previous findings (Cloutier, Ambady, Meagher, & Gabrieli, 2012), a region of interest analysis revealed the interaction of status dimension and level in VMPFC, finding not only preferential response to targets with higher compared to lower moral status as previously demonstrated, but also greater response to targets with lower compared to higher financial status. The implications of these results are discussed with an emphasis towards better understanding the impact of social status on social cognition and uncovering the neural substrates of person evaluation.