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Sample records for coradeschi satoshi tadokoro

  1. Asian Creativity: A Response to Satoshi Kanazawa

    Directory of Open Access Journals (Sweden)

    Geoffrey Miller

    2006-01-01

    Full Text Available This article responds to Satoshi Kanazawa's thoughtful and entertaining comments about my article concerning the Asian future of evolutionary psychology. Contra Kanazawa's argument that Asian cultural traditions and/or character inhibit Asian scientific creativity, I review historical evidence of high Asian creativity, and psychometric evidence of high Asian intelligence (a cognitive trait and openness to experience (a personality trait — two key components of creativity. Contra Kanazawa's concern that political correctness is a bigger threat to American evolutionary psychology than religious fundamentalism, I review evidence from research funding patterns and student attitudes suggesting that fundamentalism is more harmful and pervasive. Finally, in response to Kanazawa's focus on tall buildings as indexes of national wealth and creativity, I find that 13 of the world's tallest 25 buildings are in China, Hong Kong, or Taiwan — of which 11 were built in the last decade. Asian creativity, secularism, and architectural prominence point to a bright future for Asian science.

  2. “Thou art translated”: Remapping Hideki Noda and Satoshi Miyagi’s A Midsummer Night’s Dream in Post-March 11 Japan

    Directory of Open Access Journals (Sweden)

    Eglinton Mika

    2016-12-01

    Full Text Available Ever since the first introduction of Shakespeare to a Japanese audience in the nineteenth century, his plays have functioned as “contact zones,” which are translingual interfaces between communities and their cultures; points of negotiation, misunderstanding and mutual transformation. In the context of what is ostensibly a monolingual society, Japanese Shakespeare has produced a limited number of performances that have attempted to be multilingual. Most of them, however, turn out to be translingual, blurring the borders of linguistic specificity.

  3. Arhitektuur ja ehitus maavärinajärgses Jaapanis = The housing trend in post 3.11 Japan / Satoshi Joshua Ogawa

    Index Scriptorium Estoniae

    Ogawa, Satoshi Joshua

    2012-01-01

    Vaadeldakse looduskatastroofist toibuva Jaapani ühiskonna teisenenud arusaama kodust, kinnisvaraturu muutunud eelistusi. Taastamistöödest, elamuehitusest, arhitektide kaasatusest, viimase kümnendi arhitektuurist

  4. Hirabayashi, Satoshi; Kroll, Charles N.; Nowak, David J. 2011. Component-based development and sensitivity analyses of an air pollutant dry deposition model. Environmental Modelling & Software. 26(6): 804-816.

    Science.gov (United States)

    Satoshi Hirabayashi; Chuck Kroll; David Nowak

    2011-01-01

    The Urban Forest Effects-Deposition model (UFORE-D) was developed with a component-based modeling approach. Functions of the model were separated into components that are responsible for user interface, data input/output, and core model functions. Taking advantage of the component-based approach, three UFORE-D applications were developed: a base application to estimate...

  5. A Review of Heavy-Fueled Rotary Engine Combustion Technologies

    Science.gov (United States)

    2011-05-01

    Triangle Park, NC, 2009. 17. Shimizu, R.; Tadokoro, T.; Nakanishi, T.; Funamoto, J. Mazda 4-Rotor Rotary Engine for the Le Mans 24-Hour Endurance...2000. 102. Schock, H.; Hamady, F.; Somerton , C. Stratified Charge Rotary Engine Combustion Studies; NASA-CR-197985; National Aeronautics and

  6. Palatal rugae as a tool for human identification

    African Journals Online (AJOL)

    2014-03-10

    Mar 10, 2014 ... conducted to assess the accuracy of rugoscopy as a tool for ... assessment than dental interns (P = 0.001; confidence ... dentist following mass disaster. ... Utsuno H, Kanoh T, Tadokoro O, Inoue K. Preliminary study of post‑ ...

  7. Plaadid / Mart Normet

    Index Scriptorium Estoniae

    Normet, Mart, 1979-

    2006-01-01

    Uutest heliplaatidest Barry White "Gold", Roseanne Cash "Black Cadillac", Satoshi Tomiie "Renaissance", Tiga "Sexor", Rec ja Rapresent "Isiklikult", Yo-Yo Ma "the Essential Yo-Yo Ma", Aqua Bassino "Rue de Paris"

  8. Vudu v tjomnom kinozale / Nikolai Karajev

    Index Scriptorium Estoniae

    Karajev, Nikolai, 1978-

    2007-01-01

    PÖFFi animafilmide festivali "Animated Dreams" ja Nukufilmi 50. juubeli külalised konverentsil "Voodoo hing" olid Pjotr Sapegin, Peter Lord, Kihachiro Kawamoto. Ka Satoshi Koni täispikast animafilmist "Paprika" ja auhinnatud filmidest

  9. JAFF rebib akna alternatiivmaailmadesse

    Index Scriptorium Estoniae

    2011-01-01

    Tallinna ja Tartu kinodes 15.-24. aprillini toimuva 5. Jaapani animatsiooni filmifestivali JAFF kavast. JAFF-i teemaks on ookean. Fookuses on animemeister Satoshi Kon, festivali kavas on neli tema filmi

  10. Vselennaja po imeni "Anime" / Nikolai Karajev

    Index Scriptorium Estoniae

    Karajev, Nikolai, 1978-

    2007-01-01

    Jaapani anime filmidest, mida sai näha 19.-25. märtsil I Jaapani Animatsiooni Filmifestivalil Eestis. Ka legendaarsest animarežissöörist Satoshi Kon'ist seoses tema filmiga "Aastatuhande näitlejatar" : Jaapan 2001

  11. Influence of ROM Exercise on the Joint Components during Immobilization

    OpenAIRE

    松﨑, 太郎; Matsuzaki, Taro

    2013-01-01

    博士論文要旨Abstract 要約Outline 以下に掲載:Journal of Physical Therapy Science 25(12) pp.1547-1551 2013. The Society of Physical Therapy Science. 共著者:Taro Matsuzaki, Shinya Yoshida, Satoshi Kojima, Masanori Watanabe, Masahiro Hoso

  12. License - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available List Contact us PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods ...t list, Marker list, QTL list, Plant DB link & Genome analysis methods © Satoshi ... Policy | Contact Us License - PGDBj Registered plant list, Marker list, QTL list, Plant DB link & Genome analysis methods | LSDB Archive ...

  13. Fulltext PDF

    Indian Academy of Sciences (India)

    IAS Admin

    Satoshi Omura: Kitasato University, Tokyo, Japan. and. “for her discoveries concerning a novel therapy against Malaria” to. Youyou Tu: China Academy of Traditional Chinese Medicine, Beijing, China. Physics. "for the discovery of neutrino oscillations, which shows that neutrinos have mass" to. Takaaki Kajita: University of ...

  14. Effect of a steam foot spa on geriatric inpatients with cognitive impairment: a pilot study

    OpenAIRE

    Koike Y; Kondo H; Kondo S; Takagi M; Kano Y

    2013-01-01

    Yoshihisa Koike,1 Hideki Kondo,2 Satoshi Kondo,1 Masayuki Takagi,1 Yoshio Kano31Department of Occupational Therapy, Prefectural University of Hiroshima, Mihara, Japan; 2Yoshiigawa Hospital, Okayama, Japan; 3Department of Occupational Therapy, Kibi International University, Takahashi, JapanPurpose: To investigate whether a steam foot spa improves cognitive impairment in geriatric inpatients.Methods: Geriatric inpatients with cognitive impairment were given a steam foot spa treatment at 42&...

  15. Coping as a mediator of the relationship between stress mindset and psychological stress response: a pilot study

    OpenAIRE

    Horiuchi,Satoshi; Tsuda,Akira; Aoki,Shuntaro; Yoneda,Kenichiro; Sawaguchi,Yusuke

    2018-01-01

    Satoshi Horiuchi,1 Akira Tsuda,2 Shuntaro Aoki,3,4 Kenichiro Yoneda,5 Yusuke Sawaguchi6 1Faculty of Social Welfare, Iwate Prefectural University, Iwate, 2Department of Psychology, Kurume University, Fukuoka, 3Research Fellow of Japan Society for the Promotion of Science, Tokyo, 4Graduate School of Psychological Science, Health Sciences University of Hokkaido, Hokkaido, 5Graduate School of Psychology, Kurume University, Fukuoka, 6Graduate School of Social Welfare, Iwate Prefectural University,...

  16. The association between suicide risk and self-esteem in Japanese university students with major depressive episodes of major depressive disorder

    OpenAIRE

    Mitsui, Nobuyuki; Asakura,Satoshi; Shimizu,Yusuke; Fujii,Yutaka; Toyomaki,Atsuhito; Kako,Yuki; Tanaka,Teruaki; Kitagawa,Nobuki; Inoue,Takeshi; Kusumi,Ichiro

    2014-01-01

    Nobuyuki Mitsui,1 Satoshi Asakura,1,2 Yusuke Shimizu,1 Yutaka Fujii,1 Atsuhito Toyomaki,1 Yuki Kako,1 Teruaki Tanaka,1 Nobuki Kitagawa,3 Takeshi Inoue,1 Ichiro Kusumi1 1Department of Psychiatry, Hokkaido University Graduate School of Medicine, 2Health care center of Hokkaido University, Kita-ku, Sapporo, 3Department of Clinical Social Work, Health Sciences University of Hokkaido School of Nursing and Social Services, Tobetsu, Ishikari, Japan Background: The suicide risk among young adults is...

  17. Topical Meeting on Signal Recovery and Synthesis with Incomplete Information and Partial Constraints Held at Incline Village, Nevada on January 12-14, 1983.

    Science.gov (United States)

    1983-08-31

    Reconstruction from Phase Synchronization of Distorted Imaging Antenna Multiple Linear-Motion Tomograms, Satoshi Kawata, Arrays, Bernard D. Steinberg...phase recovery. Most other LBI imaging processes (eg. Readhead [4] and Cornwell [5]) are iterative, and the image must be deconvolved from the beam as...VLBI Data" Astrophys.J. Vol 223 July 1978 pp25-36 [5] T.J. Cornwell & P.N. Wilkinson "A New Method for Making Maps with Unstable Radio

  18. Assessment of effects of differences in trunk posture during Fowler’s position on hemodynamics and cardiovascular regulation in older and younger subjects

    OpenAIRE

    Kubota,Satoshi; Endo,Yutaka; Kubota,Mitsue; Shigemasa,Tomohiko

    2017-01-01

    Satoshi Kubota,1 Yutaka Endo,1 Mitsue Kubota,1 Tomohiko Shigemasa2 1School of Nursing and Rehabilitation Sciences at Odawara, International University of Health and Welfare, Odawara, Kanagawa, Japan; 2Department of Cardiology, International University of Health and Welfare Atami Hospital, Atami, Shizuoka, Japan Background: Downward shifts in blood volume with changing position generally cause tachycardic responses. Age-related decreases in vagal nerve activity could contribute to orthostati...

  19. An Explanation of Nakamoto's Analysis of Double-spend Attacks

    OpenAIRE

    Ozisik, A. Pinar; Levine, Brian Neil

    2017-01-01

    The fundamental attack against blockchain systems is the double-spend attack. In this tutorial, we provide a very detailed explanation of just one section of Satoshi Nakamoto's original paper where the attack's probability of success is stated. We show the derivation of the mathematics relied upon by Nakamoto to create a model of the attack. We also validate the model with a Monte Carlo simulation, and we determine which model component is not perfect.

  20. BITCOIN – A NEW GLOBAL CURRENCY, INVESTMENT OPPORTUNITY OR SOMETHING ELSE?

    OpenAIRE

    Buterin, Denis; Ribarić, Eda; Savić, Suzana

    2015-01-01

    The history of bitcoin started in 2008 when the article “Bitcoin: A Peer-to-Peer Electronic Cash System” was published under the pseudonym Satoshi Nakamoto. Since then the bitcoin has undergone significant changes marked with rapid growth and decline of its value, accompanied by public attention. The bitcoin is a system based on complex cryptographic algorithms without central authority that releases money or monitors transactions. There are discussions over the issue whether bitcoin could po...

  1. Policy Considerations for the Blockchain Technology Public and Private Applications

    OpenAIRE

    GABISON Garry

    2016-01-01

    In 2008, Satoshi Nakamoto—an individual or group of individuals— released a paper that described Bitcoin, a first of its kind, peer-to-peer electronic cash system. Bitcoin relies mostly on existing technology but requires a new invention, a blockchain, to solve an old problem: how do two parties conduct an online transaction without knowing or trusting each other and without the need for a trusted third-party intermediary? Encryption and large-scale redundancy was combined w...

  2. Storm-time electron flux precipitation in the inner radiation belt caused by wave-particle interactions

    Directory of Open Access Journals (Sweden)

    H. Tadokoro

    2009-04-01

    Full Text Available It has been believed that electrons in the inner belt do not show the dynamical variation during magnetic storms except for great magnetic storms. However, Tadokoro et al. (2007 recently disclosed that low-altitude electrons in the inner belt frequently show flux variations during storms (Storm Time inner belt Electron Enhancement at the Low altitude (STEEL. This paper investigates a possible mechanism explaining STEEL during small and moderate storms, and shows that it is caused not by radial transport processes but by pitch angle scattering through wave-particle interactions. The waves related to wave-particle interactions are attributed to be banded whistler mode waves around 30 kHz observed in the inner magnetosphere by the Akebono satellite. The estimated pitch angle distribution based on a numerical calculation is roughly consistent with the observed results.

  3. Bitcoin: Documentos electrónicos para el intercambio de bienes y servicios

    OpenAIRE

    García Alejo, Luis Antonio

    2016-01-01

    [ES] Al hablar de Bitcoin no se hace alusión simplemente a una única cosa, al bien digital como tal, sino que nos referimos también al protocolo de envío y recepción de mensajes, basado en Open Source, a la red P2P (Par- a- par) y las propias criptomonedas (Bitcoins). Su creador, bajo el seudónimo de Satoshi Nakamoto, pretendía crear un proyecto con un objetivo principal: que las transacciones económicas entre dos personas no necesiten de un organismo central o ningún tipo de intermediario. E...

  4. JPRS Report, Science & Technology, Japan, 4th Intelligent Robots Symposium, Volume 1

    Science.gov (United States)

    1989-03-16

    Robots 43064062 Tokyo 4TH INTELLIGENT ROBOTS SYMPOSIUM PAPERS in Japanese 13/14 Jun 88 No 106 pp 39-44 [Article by H. Kimura , I. Shimoyama, and H. Miura...pp 237-239. 3. K. Kondo and F. Kimura , "High-Speed Orbit Planning Based on Labyrinthine Method," Ibid., pp 261-262. 4. T. Hasegawa, "Planning of...Satoshi Okada, Kazuhiro Tsumura, Hisashi Hozeki, Katsumi Kubo, and Akira Abe, Toshiba Corporation] [Text] 1. Introduction In recent years, the

  5. Poor tolerance of beta-blockers by elderly patients with heart failure

    Directory of Open Access Journals (Sweden)

    Satoshi Yanagisawa

    2010-11-01

    Full Text Available Satoshi Yanagisawa, Noriyuki Suzuki, Toshikazu TanakaDepartment of Cardiology, Okazaki City Hospital, Aichi, JapanAbstract: Despite the well-understood importance of beta-blocker therapy in heart failure, it is sometimes not possible to use beta-blockers in elderly patients due to poor tolerance. In this report, we describe the case of an 83-year-old patient with severe systolic heart failure complicated by aortic valve stenosis and atrial fibrillation. A simple therapeutic approach involving discontinuation of beta-blockers remarkably alleviated the symptoms such as left ventricular ejection fraction, and improved the chest radiography and laboratory findings; further, atrial fibrillation converted to sinus rhythm. It is important to carefully administer beta-blocker therapy to elderly patients with heart failure, especially after considering cardiac output.Keywords: elderly, octogenarians, beta-blockers, heart failure

  6. Cine club

    CERN Multimedia

    Cine club

    2016-01-01

    Wednesday 18 May 2016 at 20:00 CERN Council Chamber Kikujiro   Directed by Takeshi Kitano Japan, 1999, 121 minutes Brash, loudmouthed and opportunistic, Kikujiro hardly seems the ideal companion for little Masao who is determined to travel long distances to see the mother he has never met. Their excursion to the cycle races is the first of a series of adventures for the unlikely pair which soon turns out to be a whimsical journey of laughter and tears with a wide array of surprises and odd ball characters to meet along the way. Original version Japanese; English subtitles Wednesday 25 May 2016 at 20:00 CERN Council Chamber Millennium Actress   Directed by Satoshi Kon  Japan, 2001, 87 minutes A TV interviewer and his cameraman meet a former actress and travel through her memories and career. Original version Japanese; English subtitles

  7. Stable Attitude of Seafloor Geodetic Benchmarks Confirmed Through Diving Surveys After the 2004 Fff-Kii Peninsula Earthquake

    Science.gov (United States)

    Fujimoto, H.; Tadokoro, K.; Okuda, T.; Matsumoto, Y.; Kido, M.; Osada, Y.; Kurihara, K.

    2006-12-01

    Tohoku University, Nagoya University, and Japan Coast Guard (JCG) deployed benchmarks for GPS/Acoustic seafloor positioning in Kumano-nada, Central Japan, which detected horizontal crustal deformation caused by the off-Kii Peninsula earthquake M7.4 on September 5, 2004 (Tadokoro et al., 2005; Kido et al., 2006). It would be the first to observe crustal deformation on the seafloor associated with an offshore earthquake. When we, working on the GPS/A seafloor positioning, reported on results of observation, we were often requested to answer the following question: "Can the benchmarks be sunk and tilted due to the shaking of the sedimented seafloor?" Indeed the benchmarks are precision acoustic transponders (PXPs) and we dropped them from the sea surface assuming soft and stable landing on the sediment. Moreover, a branch of the aftershock distribution of the off-Kii Peninsula earthquake extended close to the benchmarks. It would be the first experience for the benchmarks for cm-order seafloor geodesy to be shaked by large earthquakes. We had a chance to carry out diving surveys there by using the ROV "Dolphin 3K" of JAMSTEC during the NT06-07 cruise of the R/V Natsushima to obtain the following results. (1) We observed 10 PXPs (Tohoku 4, Nagoya 3, JCG 3) on the seafloor. All of them stood stably on the flat sedimented bottom with their bases partly sunk in the mud. We could not find any indication that the earthquake changed the attitude of some of the benchmarks. (2) We recovered one of the PXPs, which were deployed by JCG 6 years ago as the first benchmarks around the Japanese Islands. We could confirm little erosion of the instrument made of stainless frames and a glass sphere covered with a hard hut. (3) We could not find any feature on the bottom indicating local crustal deformation. This research was partly supported by the Research Revolution 2002 Program, MEXT, Japan.

  8. Effective prevention of sorafenib-induced hand–foot syndrome by dried-bonito broth

    Directory of Open Access Journals (Sweden)

    Kamimura K

    2018-04-01

    Full Text Available Kenya Kamimura,1 Yoko Shinagawa-Kobayashi,1 Ryo Goto,1 Kohei Ogawa,1 Takeshi Yokoo,1 Akira Sakamaki,1 Satoshi Abe,1 Hiroteru Kamimura,1 Takeshi Suda,2 Hiroshi Baba,3 Takayuki Tanaka,4 Yoshizu Nozawa,5 Naoto Koyama,6 Masaaki Takamura,1 Hirokazu Kawai,1 Satoshi Yamagiwa,1 Yutaka Aoyagi,1 Shuji Terai1 1Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, Japan; 2Department of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata Medical and Dental Hospital, Minami-Uonuma, Niigata, Japan; 3Division of Anesthesiology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, Japan; 4Uonuma Eye Clinic, Uonuma, Niigata, Japan; 5Institute of Food Sciences and Technologies, Ajinomoto Co., Inc., Kawasaki, Kanagawa, Japan; 6Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Kanagawa, Japan Background: Sorafenib (SOR is a molecular medicine that prolongs the survival of patients with hepatocellular carcinoma (HCC. Therefore, the management of side effects is essential for the longer period of continuous medication. Among the various side effects, hand–foot syndrome (HFS is the most common, occurring in 30%–50% of patients, and often results in discontinuation of the SOR medication. However, its mechanism has not been clarified, and no effective prevention method has been reported for the symptoms. Therefore, this study aimed to analyze its mechanism and to develop an effective prevention regimen for the symptoms. Materials and methods: To assess the mechanism of SOR-induced HFS, the peripheral blood flow in the hand and foot was carefully monitored by Doppler ultrasound, thermography, and laser speckle flowgraphy in the cases treated with SOR and its contribution was assessed. Then, the effect of dried-bonito broth (DBB, which was reported to improve peripheral blood flow, on the prevention of the symptom was

  9. Tsunami Scenario in the Nankai Trough, Japan, Based on the GPS-A and GNSS Velocities

    Science.gov (United States)

    Bock, Y.; Watanabe, S. I.; Melgar, D.; Tadokoro, K.

    2017-12-01

    We present two local tsunami scenarios for the Nankai trough, Japan, an area of significant seismic risk, using GPS-A and GNSS velocities and two different plate interface geometries to better assess the slip deficit rate. We expand on the work of Yokota et al. [2016, Nature] by: (1) Adding seafloor data collected by Nagoya University [Tadokoro et al., 2012 GRL] at the Kumano basin, (2) Aligning the geodetic data to the Nankai block (forearc sliver) to the tectonic model of Loveless and Meade [2010 JGR] - the earlier work ignored block boundaries such as the Median Tectonic Line (MTL) and may have overestimated the slip deficit rate, (3) Considering two different plate interface geometries - it is essential to use the accurate depth of the plate interface, especially for the offshore region where the faults are located near the observation sites, (4) Estimating and correcting for the postseismic displacements of the 2004 southeastern off the Kii Peninsula earthquakes (MJMA 7.1, 7.4). Based upon the refined model, we calculate the coseismic displacements and tsunami wave propagation assuming that a hundred years of constant slip deficit accumulation is released instantaneously. We used the open source software GeoClaw v5.3.1, which solves the two-dimensional shallow water equations with the finite volume technique [LeVeque, 2002 Cambridge University Press], for the local tsunami scenarios. We present the expected tsunami propagation models and wave profiles based on the geodetically-derived distribution of slip, stressing the importance of identifying fault locations and geometries. The location of the downdip edge of the coseismic rupture is essential to assess whether the coastal area would subside or not. The sensitivity to the plate interface geometries is increased in the near-trough region. From the point of view of disaster prevention, subsidence at the southern coast would heighten the tsunami runup distance (e.g., at gauges in Shimotsu and Irago). Further

  10. Fiscal 1999 achievement report on the venture business assisting type regional consortium - Minor business creation base type. Research and development of electronic signature collation system for signature on paper; 1999 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Shimen ni egaku denshi shomei shogoyo system no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The effort aims to develop and commercialize hardware and software for identifying the individual who during business transaction affixes his signature to a settlement form with a ballpoint pen or the like. Basic technologies of a tactile sensor are utilized in the construction of a ballpoint pen structured like a tactile sensor with an oscillator attached to the ink holding shaft for the pen to sense the touch of the paper. Fluctuation in the tool force exerted on the paper surface of specified hardness when writing or drawing letters or patterns are converted into frequency data. The small but highly sensitive 2-dimensional angle detecting system, developed Professor Satoshi Kiyono of Tohoku University, is incorporated into this ballpoint pen for achieving higher precision with the angle detection limits and the resolution taken into consideration. Since a strong correlation is to exist between the force exerted in the direction of roll of the ball and the angle of delicate inclination of the ink holding shaft end, tool force application and changes in the force may be continuously traced. When they are combined with a tool force detecting mechanism, a digital pen mechanism results which is capable of simultaneously reading parameters of the X, Y, and Z axes. (NEDO)

  11. Modeling and Simulation of the Economics of Mining in the Bitcoin Market

    Science.gov (United States)

    Marchesi, Michele

    2016-01-01

    In January 3, 2009, Satoshi Nakamoto gave rise to the “Bitcoin Blockchain”, creating the first block of the chain hashing on his computer’s central processing unit (CPU). Since then, the hash calculations to mine Bitcoin have been getting more and more complex, and consequently the mining hardware evolved to adapt to this increasing difficulty. Three generations of mining hardware have followed the CPU’s generation. They are GPU’s, FPGA’s and ASIC’s generations. This work presents an agent-based artificial market model of the Bitcoin mining process and of the Bitcoin transactions. The goal of this work is to model the economy of the mining process, starting from GPU’s generation, the first with economic significance. The model reproduces some “stylized facts” found in real-time price series and some core aspects of the mining business. In particular, the computational experiments performed can reproduce the unit root property, the fat tail phenomenon and the volatility clustering of Bitcoin price series. In addition, under proper assumptions, they can reproduce the generation of Bitcoins, the hashing capability, the power consumption, and the mining hardware and electrical energy expenditures of the Bitcoin network. PMID:27768691

  12. Critical appraisal and pooled analysis of telmisartan alone or in combination with hydrochlorothiazide for achieving blood pressure goals

    Directory of Open Access Journals (Sweden)

    Satoshi Morimoto

    2010-06-01

    Full Text Available Satoshi Morimoto, Nobuyuki Takahashi, Tatsuyori Morita, Kazunori Someya, Nagaoki Toyoda, Toshiji IwasakaSecond Department of Internal Medicine, Kansai Medical University 2-3-1, Shinmachi, Hirakata, Osaka 573-1191, JapanAbstract: Rigid control of blood pressure (BP is essential to prevent cardiovascular disease. However, only about 40% of hypertensive patients undergoing pharmacological intervention with a single agent achieve their BP goals in contemporary clinical practice. Combined therapy using currently available agents is effective in maximizing treatment outcome, although it raises medical costs and decreases the drug compliance rate. To overcome such negative consequences, a combination tablet containing an angiotensin II receptor blocker (ARB with a small dose of hydrochlorothiazide (HCTZ is now available on the international market, including Japan. This article briefly describes the unique properties of telmisartan, a highly selective ARB for the angiotensin II type 1 receptor, including its long-acting characteristics and recent prospective multicenter randomized clinical trials, followed by a description of a newly-introduced combination tablet in Japan, which contains telmisartan and HCTZ. This article also reviews its safety and efficacy based on currently available evidence. Finally, evidence comparing telmisartan/HCTZ with other combination therapies is presented.Keywords: angiotensin II receptor blocker, ARB, blood pressure, hypertension, diuretics, PPAR-γ

  13. Readings from Asia: Memory: Troublesome, Irrepressible, and (Painfully Illuminating

    Directory of Open Access Journals (Sweden)

    Kyu Hyun Kim

    2013-09-01

    Full Text Available Nakano Satoshi 中野聡. 東南アジア占領と日本人: 帝国・日本の解体 [The occupation of Southeast Asia and the Japanese: Dissolution of the Japanese empire]. Itagaki Ryūta 板垣竜太, Chŏng Chi-yŏng 鄭智永, and Iwasaki Minoru 岩崎稔 eds. 東アジアの記憶の場 [The site of memories in East Asia]. "Readings from Asia" highlights significant recent scholarship published in Chinese, Korean, Japanese, and Vietnamese, in order to bring it to the attention of a wider, international readership. This issue of Cross-Currents features a review by Kyu Hyun Kim (University of California, Davis of two recent titles in Japanese: Nakano Satoshi’s 東南アジア占領と日本人: 帝国・日本の解体 and 東アジアの記憶の場, edited by Itagaki Ryūta, Chŏng Chi-yŏng, and Iwasaki Minoru. Kim recommends both books, with their “even-handed understanding of the corrective power of memory as well as its pitfalls,” to Japanese-language readers interested in the intersection of memory and history, as well as to students of modern Japanese and Korean history.

  14. Functional and gene expression analysis of hTERT overexpressed endothelial cells

    Directory of Open Access Journals (Sweden)

    Haruna Takano

    2008-09-01

    Full Text Available Haruna Takano1, Satoshi Murasawa1,2, Takayuki Asahara1,2,31Institute of Biomedical Research and Innovation, Kobe, Japan; 2RIKEN Center for Developmental Biology, Kobe 650-0047, Japan; 3Tokai University of School of Medicine, Tokai, JapanAbstract: Telomerase dysfunction contributes to cellular senescence. Recent advances indicate the importance of senescence in maintaining vascular cell function in vitro. Human telomerase reverse transcriptase (hTERT overexpression is thought to lead to resistance to apoptosis and oxidative stress. However, the mechanism in endothelial lineage cells is unclear. We tried to generate an immortal endothelial cell line from human umbilical vein endothelial cells using a no-virus system and examine the functional mechanisms of hTERT overexpressed endothelial cell senescence in vitro. High levels of hTERT genes and endothelial cell-specific markers were expressed during long-term culture. Also, angiogenic responses were observed in hTERT overexpressed endothelial cell. These cells showed a delay in senescence and appeared more resistant to stressed conditions. PI3K/Akt-related gene levels were enhanced in hTERT overexpressed endothelial cells. An up-regulated PI3K/Akt pathway caused by hTERT overexpression might contribute to anti-apoptosis and survival effects in endothelial lineage cells.Keywords: endothelial, telomerase, senescence, oxidative stress, anti-apoptosis, PI3K/Akt pathway

  15. Cine club

    CERN Multimedia

    Cine club

    2017-01-01

    Wednesday 15 February 2017 at 20:00 CERN Council Chamber Waking Life Directed by Richard Linklater USA, 2001, 99 minutes This is the story of a boy who has a dream that he can float, but unless he holds on, he will drift away into the sky. Even when he is grown up, this idea recurs. After a strange accident, he walks through what may be a dream, flowing in and out of scenarios and encountering various characters. People he meets discuss science, philosophy and the life of dreaming and waking, and the protagonist gradually becomes alarmed that he cannot awake from this confusing dream adventure. Original version English; French subtitles Wednesday 22 February 2017 at 20:00 CERN Council Chamber Paprika Directed by Satoshi Kon Japan, 2006, 90 minutes When a machine that allows therapists to enter their patients' dreams is stolen, all Hell breaks loose. Only a young female therapist, Paprika, can stop it. Original version Japanese; English subtitles Save

  16. BITCOIN - THE CURRENCY OF A NEW ECONOMY?

    Directory of Open Access Journals (Sweden)

    CARINA-ELENA STEGĂROIU

    2017-12-01

    Full Text Available In the knowledge society, a new economy is emerging, New Economy, which also encompasses the Internet economy in the form of e-bussines, which is why the economy is the economy of information society and knowledge. So, in a knowledge-based technology, a new digital coin was also needed in the field of electronic payments, thus creating the virtual currency BITCOIN (BTC, which in a moto translation is the bit of the bit (the unit of measure of the amount of information. It is a decentralized electronic payment system and a digital encrypted opensurce created in 2009 by Satoshi Nakamoto. The need to create Bitcoin (BTC was to ensure investment protection and free business finance, without resorting to financial institutions and beyond any constraints and regulations. The Bitcoin name also refers to the opensource program for using these coins, as well as the peer-to-peer (peer-to peer network it forms. Currently, even if he has many opponents and has gone through several difficult times, Bitcoin seems to survive and offer new technology with revolutionary use possibilities. The concept of the digital coin fits perfectly with the everchanging world, dominated by mobile and omnipresent technology. Compared to Bitcoin or another digital coin, any visit to the bank seems like a trip to another century, an era of time lost at the counter completing dozens of unnecessary papers.

  17. Modeling and Simulation of the Economics of Mining in the Bitcoin Market.

    Science.gov (United States)

    Cocco, Luisanna; Marchesi, Michele

    2016-01-01

    In January 3, 2009, Satoshi Nakamoto gave rise to the "Bitcoin Blockchain", creating the first block of the chain hashing on his computer's central processing unit (CPU). Since then, the hash calculations to mine Bitcoin have been getting more and more complex, and consequently the mining hardware evolved to adapt to this increasing difficulty. Three generations of mining hardware have followed the CPU's generation. They are GPU's, FPGA's and ASIC's generations. This work presents an agent-based artificial market model of the Bitcoin mining process and of the Bitcoin transactions. The goal of this work is to model the economy of the mining process, starting from GPU's generation, the first with economic significance. The model reproduces some "stylized facts" found in real-time price series and some core aspects of the mining business. In particular, the computational experiments performed can reproduce the unit root property, the fat tail phenomenon and the volatility clustering of Bitcoin price series. In addition, under proper assumptions, they can reproduce the generation of Bitcoins, the hashing capability, the power consumption, and the mining hardware and electrical energy expenditures of the Bitcoin network.

  18. Modeling and Simulation of the Economics of Mining in the Bitcoin Market.

    Directory of Open Access Journals (Sweden)

    Luisanna Cocco

    Full Text Available In January 3, 2009, Satoshi Nakamoto gave rise to the "Bitcoin Blockchain", creating the first block of the chain hashing on his computer's central processing unit (CPU. Since then, the hash calculations to mine Bitcoin have been getting more and more complex, and consequently the mining hardware evolved to adapt to this increasing difficulty. Three generations of mining hardware have followed the CPU's generation. They are GPU's, FPGA's and ASIC's generations. This work presents an agent-based artificial market model of the Bitcoin mining process and of the Bitcoin transactions. The goal of this work is to model the economy of the mining process, starting from GPU's generation, the first with economic significance. The model reproduces some "stylized facts" found in real-time price series and some core aspects of the mining business. In particular, the computational experiments performed can reproduce the unit root property, the fat tail phenomenon and the volatility clustering of Bitcoin price series. In addition, under proper assumptions, they can reproduce the generation of Bitcoins, the hashing capability, the power consumption, and the mining hardware and electrical energy expenditures of the Bitcoin network.

  19. Effect of a steam foot spa on geriatric inpatients with cognitive impairment: a pilot study

    Directory of Open Access Journals (Sweden)

    Koike Y

    2013-05-01

    Full Text Available Yoshihisa Koike,1 Hideki Kondo,2 Satoshi Kondo,1 Masayuki Takagi,1 Yoshio Kano31Department of Occupational Therapy, Prefectural University of Hiroshima, Mihara, Japan; 2Yoshiigawa Hospital, Okayama, Japan; 3Department of Occupational Therapy, Kibi International University, Takahashi, JapanPurpose: To investigate whether a steam foot spa improves cognitive impairment in geriatric inpatients.Methods: Geriatric inpatients with cognitive impairment were given a steam foot spa treatment at 42°C for 20 minutes for 2 weeks (5 days/week. Physiological indicators such as blood pressure, percutaneous oxygen saturation, pulse, tympanic temperature, and sleep time and efficiency were assessed. Cognitive function and behavioral and psychological symptoms of dementia were assessed using the Mini-Mental State Examination, Dementia Mood Assessment Scale, and Dementia Behavior Disturbance scale.Results: Significant decreases in systolic (P < 0.01 and diastolic blood pressure (P < 0.05 along with a significant increase in tympanic temperature (P < 0.01 were observed after the steam foot spas. A significant improvement was seen in the Mini-Mental State Examination score (P < 0.01 and the overall dementia severity items in Dementia Mood Assessment Scale (P < 0.05.Limitations: Japanese people are very fond of foot baths. However, it is difficult to understand why inpatients cannot receive steam foot baths. In this study, a control group was not used. Raters and enforcers were not blinded.Conclusion: The results of this pilot study suggest that steam foot spas mitigate cognitive impairment in geriatric inpatients.Keywords: steam foot spa, geriatric inpatients, cognitive impairment, tympanic temperature

  20. Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis

    Directory of Open Access Journals (Sweden)

    Ueda S

    2016-02-01

    Full Text Available Satoshi Ueda,1 Takeshi Sakayori,1 Ataru Omori,2 Hajime Fukuta,3 Takashi Kobayashi,3 Kousuke Ishizaka,1 Tomoyuki Saijo,4 Yoshiro Okubo1 1Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan; 2Tamachuo Hospital, Tokyo, Japan; 3Kurumegaoka Hospital, Tokyo, Japan; 4Saijo Clinic, Tokyo, Japan Abstract: Neuroleptics can induce not only physical adverse effects but also mental effects that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced deficit syndrome (NIDS, which includes apathy, lack of initiative, anhedonia, indifference, blunted affect, and reduced insight into disease. Although this old concept now appears almost forgotten, neuroleptics, whether typical or atypical, can make depression or bipolar disorder resemble other more refractory conditions, readily leading to mistaken diagnosis and inappropriate treatment. The authors describe three cases of NIDS superimposed on depressive phase in bipolar disorder with psychosis, where the attending psychiatrist’s failure to recognize NIDS prevented patients from receiving effective treatment and achieving remission. All cases achieved remission after reduction of neuroleptics and intensive therapy, including electroconvulsive therapy, for bipolar depression. The concept of NIDS was originally introduced for schizophrenia, and it has rarely been highlighted in other diseases. In recent years, however, atypical antipsychotics are being more often administered to patients with bipolar disorder. Psychiatrists, therefore, should also remember and exercise caution regarding NIDS in the pharmacotherapy of bipolar disorder with and without psychosis. The authors believe that the concept of NIDS needs to be reappraised in current psychiatry. Keywords: neuroleptic-induced deficit syndrome (NIDS, bipolar disorder, psychosis, atypical antipsychotics, electroconvulsive therapy

  1. Comparison of DLK incidence after laser in situ keratomileusis associated with two femtosecond lasers: Femto LDV and IntraLase FS60

    Directory of Open Access Journals (Sweden)

    Tomita M

    2013-07-01

    Full Text Available Minoru Tomita,1–3 Yuko Sotoyama,1 Satoshi Yukawa,1 Tadayuki Nakamura1 1Shinagawa LASIK Center, Chiyoda-ku, Tokyo, Japan; 2Department of Ophthalmology, Wenzhou Medical College, Wenzhou, People’s Republic of China; 3Eye Can Cataract Surgery Center, Manila, Philippines Purpose: To compare the incidence of diffuse lamellar keratitis (DLK after laser in situ keratomileusis (LASIK with flap creation using the Femto LDV and IntraLase™ FS60 femtosecond lasers. Methods: A total of 818 consecutive myopic eyes had LASIK performed using either Femto LDV or IntraLase FS60 for flap creation. The same excimer laser, the Allegretto Wave® Eye-Q Laser, was used for correcting refractive errors for all patients. In the preoperative examination, uncorrected distance visual acuity, corrected distance visual acuity, and manifest refraction spherical equivalent were measured. At the postop examination, the same examinations were performed along with a slit-lamp biomicroscopic examination, and patients with DLK were classified into stages. For the statistical analysis of the DLK occurrence rate and the visual and refractive outcomes, the Mann-Whitney’s U-test was used. Results: In the Femto LDV group with 514 eyes, 42 (8.17% had DLK. In the IntraLase FS60 group with 304 eyes, 114 (37.5% had DLK. There was a statistically significant difference in the DLK incidence rate between these groups (P < 0.0001. Both groups had excellent visual and refractive outcomes. Although low levels of DLK were observed for both groups, they did not affect visual acuity. Conclusion: While there were significantly fewer incidences of low level DLK when using Femto LDV, neither femtosecond laser induced high levels of DLK, and any postoperative DLK cleared up within 1 week. Therefore, both lasers provide excellent results, with no clinical differences, and both excel at flap creation for LASIK. Keywords: LASIK, Ziemer, Femto LDV, DLK, IntraLase FS60, femtosecond laser

  2. THE NEW ERA OF FINANCIAL INNOVATION: THE DETERMINANTS OF BITCOIN’S PRICE

    Directory of Open Access Journals (Sweden)

    Sukmawati Sukamulja

    2018-01-01

    Full Text Available Financial innovation has entered a new era in which a digitalized system and cryptocurrency have been created. This paper examines the factors that influence the price movement of bitcoin. This is not a legal currency in Indonesia; the Indonesian government has not made any regulations legalizing bitcoin’s use, but it has also not issued any new laws to prohibit the trade in bitcoins and other digital currencies. The demand for, and price growth of, bitcoin are interesting matters to study, especially for Indonesians who still have questions about the progress of Bitcoin transactions and the factors that influent them. In Indonesia itself, without any protection from the government, the bitcoin price on December 14, 2017 had already reached more than IDR224.5 million, compare to IDR60 million in October 2017. Bitcoin is the first peer-to-peer currency, and was introduced by Satoshi Nakamoto in 2008. Since its inception, bitcoin has served more than 17 million users, including Indonesians. Bitcoin behaves in a different manner, compared to traditional currencies and the one that affects bitcoin’s price is its attractiveness for investors. The Vector Error Correction Model (VECM is applied to analyze the short-term and long-term influences. VECM is used in this research because the data is stationary in the first difference and has a cointegration relationship. To make the interpretation clearer, the impulse response function and variance decomposition also are included in this research. The result indicates that the macroeconomic indicator, represented by the Dow Jones Industrial Average (DJIA, the demand for bitcoins and the gold price influence bitcoin’s price fluctuations in the short-run and long-run. Bitcoin’s supply does not influence its price fluctuation in the long-run but does influence it in the short-run. The implication of this research is bitcoin could compete as an alternative investment compared to the capital markets and

  3. List of participants at SIDE IV meeting, Tokyo, 27 November--1 December 2000

    Science.gov (United States)

    2001-12-01

    Mark J Ablowitz, Vsevolod Adler, Mark Alber, Said Belmehdi, Marco Boiti, Claude Brezinski, R Bullough, Y M Chiang, Theodore Chihara, Peter A Clarkson, Robert Conte, Adam Doliwa, Vladimir Dorodnitsyn, Mitsuaki Eguchi, Claire Gilson, Basil Grammaticos, Valeri Gromak, Rod Halburd, Koji Hasegawa, Jarmo Hietarinta, Ryogo Hirota, Xing Biao Hu, M Idzumi, J Inoguchi, Hiroya Ishikara, Mourad Ismail, Shin Isojima, Kenichi Ito, Yoshiaki Itoh, Masashi Iwasaki, Klara Janglajew, Michio Jimbo, Nalini Joshi, Kenji Kajiwara, Saburo Kakei, Masaru Kamata, Satoshi Kamei, Rinat Kashaev, Shingo Kawai, Taeko Kimijima, K Kimura, Anatol Kirillov, Koichi Kondo, Boris Konopelchenko, Martin Kruskal, Atsuo Kuniba, Wataru Kunishima, Franklin Lambert, Serguei Leble, Decio Levi, Shigeru Maeda, Manuel Manas, Ken-Ichi Maruno, Tetsu Masuda, J Matsukidaira, Atsushi Matsumiya, Shigeki Matsutani, Yukitaka Minesaki, Mikio Murata, Micheline Musette, Atsushi Nagai, Katsuya Nakagawa, Atsushi Nakamula, Akira Nakamura, Yoshimasa Nakamura, Frank Nijhoff, J J C Nimmo, Katsuhiro Nishinari, Michitomo Nishizawa, A Nobe, Masatoshi Noumi, Yaeko Ohsaki, Yasuhiro Ohta, Kazuo Okamoto, Alexandre Orlov, Naoki Osada, Flora Pempinelli, Spiro Pyrlis, Reinout Quispel, Orlando Ragnisco, Alfred Ramani, Jean-Pierre Ramis, Andreas Ruffing, Simon Ruijsenaars, Satoru Saito, Noriko Saitoh, Hidetaka Sakai, Paulo Santini, Narimasa Sasa, Ryu Sasaki, Yoshikatsu Sasaki, Junkichi Satsuma, Sergei Sergeev, Nobuhiko Shinzawa, Evgueni Sklyanin, Juris Suris, Norio Suzuki, Yukiko Tagami, Katsuaki Takahashi, Daisuke Takahashi, Tomoyuki Takenawa, Yoshiro Takeyama, K M Tamizhmani, T Tamizhmani, Kouichi Toda, Morikatsu Toda, Tetsuji Tokihiro, Takayuki Tsuchida, Yohei Tsuchiya, Teruhisa Tsuda, Satoru Tsujimoto, Walter Van Assche, Claude Viallet, Luc Vinet, Shinsuke Watanabe, Yoshihida Watanabe, Ralph Willox, Pavel Winternitz, Yasuhiko Yamada, Yuji Yamada, Jin Yoneda, Haruo Yoshida, Katsuhiko Yoshida, Daisuke Yoshihara, Fumitaka Yura, J

  4. Managing refractory Crohn's disease: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Tanida S

    2015-04-01

    Full Text Available Satoshi Tanida, Keiji Ozeki, Tsutomu Mizoshita, Hironobu Tsukamoto, Takahito Katano, Hiromi Kataoka, Takeshi Kamiya, Takashi Joh Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Aichi Prefecture, Japan Abstract: The goals of treatment for active Crohn's disease (CD are to achieve clinical remission and improve quality of life. Conventional therapeutics for moderate-to-severe CD include 5-aminosalicylic acid, corticosteroids, purine analogs, azathioprine, and 6-mercaptopurine. Patients who fail to respond to conventional therapy are treated with tumor necrosis factor (TNF-α inhibitors such as infliximab and adalimumab, but their efficacy is limited due to primary nonresponse or loss of response. It is suggested that this requires switch to another TNF-α inhibitor, a combination therapy with TNF-α blockade plus azathioprine, or granulocyte and monocyte adsorptive apheresis, and that other therapeutic options having different mechanisms of action, such as blockade of inflammatory cytokines or adhesion molecules, are needed. Natalizumab and vedolizumab are neutralizing antibodies directed against integrin a4 and a4ß7, respectively. Ustekinumab is a neutralizing antibody directed against the receptors for interleukin-12 and interleukin-23. Here, we provide an overview of therapeutic treatments that are effective and currently available for CD patients, as well as some that likely will be available in the near future. We also discuss the advantages of managing patients with refractory CD using a combination of TNF-α inhibitors plus azathioprine or intensive monocyte adsorptive apheresis. Keywords: adalimumab, granulocyte and monocyte adsorptive apheresis, combination therapy, complete remission

  5. A recurrent ovarian cancer patient with a history of nine prior chemotherapy regimens who was safely treated with weekly paclitaxel plus bevacizumab and achieved a complete response: a case report

    Directory of Open Access Journals (Sweden)

    Takatori E

    2015-08-01

    Full Text Available Eriko Takatori,1 Tadahiro Shoji,1 Takayuki Nagasawa,1 Satoshi Takeuchi,1 Akira Hosoyachi,2 Toru Sugiyama1 1Department of Obstetrics and Gynecology, School of Medicine, Iwate Medical University, Morioka, Japan; 2Department of Obstetrics and Gynecology, Iwate Prefectural Miyako Hospital, Miyako, Japan Abstract: Herein, we describe our experience with a recurrent ovarian cancer patient who was treated safely with bevacizumab and who achieved a complete response despite receiving nine prior chemotherapy regimens. The patient was a 54-year-old woman with stage IIIC recurrent ovarian serous adenocarcinoma (grade 3. Computed tomography (CT revealed that no evidence of ascites, multiple intraperitoneal dissemination, or intrapelvic lymph node metastases was present. The absence of bowel obstruction and disseminated lesions involving the intestinal tract was confirmed by CT. Performance status was 0, and a blood test also indicated preservation of major organ function. In our hospital, weekly paclitaxel plus bevacizumab therapy (paclitaxel at 80 mg/m2 on days 1, 8, and 15; bevacizumab at 15/mg/kg on day 1 and every 21 days thereafter was started. Eight cycles were administered, with no signs of gastrointestinal perforation, and the antitumor effect was evaluated as a complete response. The observed adverse events included grade 1 hyponatremia and grade 1 hypochloremia, and there was one grade 1 sensory peripheral neuropathy. These adverse events neither delayed treatment nor necessitated any dosage reductions. This case suggests that bevacizumab can be safely administered even to patients with recurrent ovarian cancer who have received three or more prior chemotherapy regimens if there are neither symptoms of bowel obstruction nor lesions suggestive of intestinal invasion on diagnostic imaging. Keywords: recurrent ovarian cancer, gastrointestinal perforation 

  6. Coping as a mediator of the relationship between stress mindset and psychological stress response: a pilot study

    Directory of Open Access Journals (Sweden)

    Horiuchi S

    2018-03-01

    Full Text Available Satoshi Horiuchi,1 Akira Tsuda,2 Shuntaro Aoki,3,4 Kenichiro Yoneda,5 Yusuke Sawaguchi6 1Faculty of Social Welfare, Iwate Prefectural University, Iwate, 2Department of Psychology, Kurume University, Fukuoka, 3Research Fellow of Japan Society for the Promotion of Science, Tokyo, 4Graduate School of Psychological Science, Health Sciences University of Hokkaido, Hokkaido, 5Graduate School of Psychology, Kurume University, Fukuoka, 6Graduate School of Social Welfare, Iwate Prefectural University, Iwate, Japan Background: Coping, the cognitive and behavioral effort required to manage the effects of stressors, is important in determining psychological stress responses (ie, the emotional, behavioral, and cognitive responses to stressors. Coping was classified into categories of emotional expression (eg, negative feelings and thoughts, emotional support seeking (eg, approaching loved ones to request encouragement, cognitive reinterpretation (eg, reframing a problem positively, and problem solving (eg, working to solve the problem. Stress mindset refers to the belief that stress has enhancing (stress-is-enhancing mindset or debilitating consequences (stress-is-debilitating mindset. This study examined whether coping mediated the relationship between stress mindset and psychological stress responses. Psychological stress responses were conceptualized as depression-anxiety, irritability-anger, and helplessness. The following two hypotheses were tested: 1 a stronger stress-is-enhancing mindset is associated with less frequent use of emotional expression, emotional support seeking, and problem solving, which in turn is associated with lower levels of depression-anxiety, irritability-anger, and helplessness; 2 a stronger stress-is-debilitating mindset is associated with more frequent use of these coping strategies, which in turn is associated with higher levels of these psychological stress responses. Materials and methods: The participants were 30 male and

  7. Iterative reconstruction for quantitative computed tomography analysis of emphysema: consistent results using different tube currents

    Directory of Open Access Journals (Sweden)

    Yamashiro T

    2015-02-01

    Full Text Available Tsuneo Yamashiro,1 Tetsuhiro Miyara,1 Osamu Honda,2 Noriyuki Tomiyama,2 Yoshiharu Ohno,3 Satoshi Noma,4 Sadayuki Murayama1 On behalf of the ACTIve Study Group 1Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Okinawa, Japan; 2Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 3Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; 4Department of Radiology, Tenri Hospital, Tenri, Nara, Japan Purpose: To assess the advantages of iterative reconstruction for quantitative computed tomography (CT analysis of pulmonary emphysema. Materials and methods: Twenty-two patients with pulmonary emphysema underwent chest CT imaging using identical scanners with three different tube currents: 240, 120, and 60 mA. Scan data were converted to CT images using Adaptive Iterative Dose Reduction using Three Dimensional Processing (AIDR3D and a conventional filtered-back projection mode. Thus, six scans with and without AIDR3D were generated per patient. All other scanning and reconstruction settings were fixed. The percent low attenuation area (LAA%; < -950 Hounsfield units and the lung density 15th percentile were automatically measured using a commercial workstation. Comparisons of LAA% and 15th percentile results between scans with and without using AIDR3D were made by Wilcoxon signed-rank tests. Associations between body weight and measurement errors among these scans were evaluated by Spearman rank correlation analysis. Results: Overall, scan series without AIDR3D had higher LAA% and lower 15th percentile values than those with AIDR3D at each tube current (P<0.0001. For scan series without AIDR3D, lower tube currents resulted in higher LAA% values and lower 15th percentiles. The extent of emphysema was significantly different between each pair among scans when not using AIDR3D (LAA%, P<0.0001; 15th percentile, P<0.01, but was not

  8. A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief

    Directory of Open Access Journals (Sweden)

    Inoue S

    2017-08-01

    Full Text Available Satoshi Inoue,1 Yoji Saito,2 Satoru Tsuneto,3 Etsuko Aruga,4 Azusa Ide,1 Yasuyuki Kakurai5 1Clinical Development Department, R&D Division, Daiichi Sankyo, Tokyo,2Department of Anesthesiology, Faculty of Medicine, Shimane University, Shimane, 3Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 4Department of Palliative Medicine, School of Medicine, Teikyo University, Tokyo, 5Biostatistics and Data Management Department, R&D Division, Daiichi Sankyo, Tokyo, Japan Background: In Japan, there are limited options for switching opioid analgesics. Hydromorphone is an opioid analgesic that is routinely used instead of morphine for cancer pain; however, it is not yet available in Japan. The aim of this study was to assess the efficacy and safety of hydromorphone (DS-7113b extended-release tablets in opioid-naïve patients with cancer pain not relieved by non-opioid analgesics.Subjects and methods: This was a multicenter, randomized, double-blind, parallel-group trial. A double-dummy method was used for blinding. Each randomized subject received either hydromorphone extended-release tablets plus placebo oxycodone hydrochloride extended-release tablets 4 mg/day (n=88 or placebo hydromorphone extended-release tablets plus oxycodone hydrochloride extended-release tablets 10 mg/day (n=93 orally for 7 days (once-daily dosing for hydromorphone and twice-daily dosing for oxycodone. The doses were adjusted as necessary. Efficacy was evaluated by change in visual analog scale (VAS score from baseline to completion of treatment.Results: The between-group difference in least squares mean changes in VAS score from baseline to completion or discontinuation of treatment was −0.4 mm (95% CI −5.9 to 5 mm by analysis of covariance where the baseline VAS score was used as a covariate. The upper limit of the 95% CI was below 10 mm, which was predefined as the noninferiority limit. This verified the noninferiority of hydromorphone tablets

  9. Assessment of effects of differences in trunk posture during Fowler’s position on hemodynamics and cardiovascular regulation in older and younger subjects

    Directory of Open Access Journals (Sweden)

    Kubota S

    2017-03-01

    Full Text Available Satoshi Kubota,1 Yutaka Endo,1 Mitsue Kubota,1 Tomohiko Shigemasa2 1School of Nursing and Rehabilitation Sciences at Odawara, International University of Health and Welfare, Odawara, Kanagawa, Japan; 2Department of Cardiology, International University of Health and Welfare Atami Hospital, Atami, Shizuoka, Japan Background: Downward shifts in blood volume with changing position generally cause tachycardic responses. Age-related decreases in vagal nerve activity could contribute to orthostatic hypotension in older individuals. Fowler’s position is a reclined position with the back between 30° and 60°, used to facilitate breathing, eating, and other routine daily activities in frail and elderly patients. Objective: This study examined whether stroke volume (SV was higher and heart rate (HR lower in Fowler’s position with an upright upper trunk than in Fowler’s position with the whole trunk upright in both older and younger subjects, based on the assumption that lower HR would result from reduced sympathetic activation in older individuals. Methods: We assessed hemodynamics and HR variability from electrocardiography, noninvasive arterial pressure and impedance cardiography in 11 younger male subjects (age range, 20–22 years and 11 older male subjects (age range, 64–79 years, using three positions: supine, or Fowler’s positions with either 30° of lower trunk inclination and 60° of upper trunk inclination (UT60 or 60° of whole trunk inclination (WT60. Comparisons were then made between age groups and between positions. Results: Reductions in SV and tachycardic response were smaller with UT60 than with WT60, in both younger and older subjects. In addition, reduced tachycardic response with upright upper trunk appeared attributable to decreased vagal withdrawal in younger subjects and to reduced sympathetic activation in older subjects. Conclusion: Our findings indicate that an upright upper trunk during Fowler’s position allowed

  10. Association of perfectionistic and dependent dysfunctional attitudes with subthreshold depression

    Directory of Open Access Journals (Sweden)

    Horiuchi S

    2017-08-01

    Full Text Available Satoshi Horiuchi,1 Shuntaro Aoki,2,3 Koki Takagaki,4 Fumihito Shoji5 1Faculty of Social Welfare, Iwate Prefectural University, Iwate, Japan; 2Graduate School of Psychological Science, Health Sciences University of Hokkaido, Hokkaido, Japan; 3Japan Society for the Promotion of Science, Tokyo, Japan; 4Department of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan; 5Graduate School of Social Welfare, Iwate Prefectural University, Iwate, Japan Background: Dysfunctional attitudes are beliefs and attitudes that induce negative thoughts about the self, others, and the future, leading to depression. Perfectionistic dysfunctional attitudes are beliefs and attitudes about achievement and excessive fear of failure, while dependent dysfunctional attitudes are beliefs and attitudes about dependency on, and approval from, others. Subthreshold depression refers to a depressive state that does not meet the diagnostic criteria for a major depressive episode. This study examined whether the difference in perfectionistic dysfunctional attitudes between college students with subthreshold depression and those with no depression would be greater than that of dependent dysfunctional attitudes.Methods: Participants were defined as having subthreshold depression if they scored 16 or higher on the Japanese version of the Center for Epidemiologic Studies Depression Scale but did not meet the diagnostic criteria for a major depressive episode, as assessed by the major depressive episode module of the Mini-International Neuropsychiatric Interview. The participants included 21 male and 87 female college students, with a mean age of 20.3 years. Dysfunctional attitudes were evaluated with the Japanese version of the 24-item Dysfunctional Attitude Scale.Results: Of the 108 students, 34 had subthreshold depression while 74 had no depression. The magnitudes of the differences in perfectionistic and dependent dysfunctional attitudes between the students with

  11. Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir

    Directory of Open Access Journals (Sweden)

    Suzuki F

    2014-06-01

    Full Text Available Fumitaka Suzuki,1,2 Hitomi Sezaki,1 Norio Akuta,1 Yoshiyuki Suzuki,1 Yusuke Kawamura,1 Tetsuya Hosaka,1 Masahiro Kobayashi,1 Satoshi Saitoh,1 Yasuji Arase,1 Kenji Ikeda,1 Mariko Kobayashi,3 Sachiyo Watahiki,3 Rie Mineta,3 Yukiko Suzuki,3 Hiromitsu Kumada1 1Department of Hepatology, Toranomon Hospital, Tokyo, Japan; 2Okinaka Memorial Institute for Medical Research, Tokyo, Japan; 3Research Institute for Hepatology, Toranomon Branch Hospital, Kawasaki, Japan Abstract: Tenofovir disoproxil fumarate (TDF is widely used to treat hepatitis B virus (HBV patients in the USA and Europe. No confirmed report of resistance selection during treatment with TDF in treatment-naïve and nucleoside/nucleotide analog-treated chronic hepatitis B patients has yet been reported. Here, we report for the first time a patient with chronic hepatitis B and cirrhosis who emerged with virologic breakthrough during combination therapy with TDF and entecavir (ETV, against ETV-resistant virus. A 51-year-old Japanese woman with hepatitis B e-antigen (HBeAg, whose genotype was C, received ETV monotherapy continuously followed by TDF and ETV combination therapy, because her HBV DNA levels had been >3.5 log copies/mL. At the start of combination therapy, amino acid substitutions of the reverse transcriptase (rt gene, rtL180M, rtT184I/M, and rtM204V, were detected. After this, serum HBV DNA decreased to less than 2.1 log copies/mL and remained at this level until 31 months of combination therapy, when it again began to increase. Amino acid substitutions of rtL180M, rtS202G, and rtM204V emerged and were associated with an increase in serum HBV DNA at virologic breakthrough. Long-term therapy with TDF against the ETV-resistant virus has the potential to induce virologic breakthrough and resistance, and careful follow-up should be carried out. Keywords: hepatitis B virus, resistant

  12. Factor structure, reliability, and validity of the Japanese version of the Hoarding Rating Scale-Self-Report (HRS-SR-J

    Directory of Open Access Journals (Sweden)

    Tsuchiyagaito A

    2017-05-01

    Full Text Available Aki Tsuchiyagaito,1–3 Satoshi Horiuchi,4 Toko Igarashi,5 Yoshiya Kawanori,4 Yoshiyuki Hirano,1,3 Hirooki Yabe,2 Akiko Nakagawa1,3 1Research Center for Child Mental Development, Chiba University, Chiba, 2Department of Neuropsychiatry, Fukushima Medical University, Fukushima, 3United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, 4Faculty of Social Welfare, Iwate Prefectural University, Iwate, 5Graduate School of Education, Joetsu University of Education, Niigata, Japan Background: The Hoarding Rating Scale-Self-Report (HRS-SR is a five-item scale that assesses the symptoms of hoarding. These symptoms include excessive acquisition, difficulty in discarding, and excessive clutter that causes distress. We conducted three studies to examine the factor structure, reliability, and validity of the Japanese version of the HRS-SR (HRS-SR-J. Methods: Study 1 examined its reliability; 193 college students and 320 adolescents and adults completed the HRS-SR-J and, of the college students, 32 took it again 2 weeks later. Study 2 aimed to confirm that its scores in a sample of 210 adolescents and adults are independent of social desirability. Study 3 aimed to validate the HRS-SR-J in the aspects of convergent and discriminant validity in a sample of 550 adults. Results: The HRS-SR-J showed good internal consistency and 2-week test–retest reliability. Based on the nonsignificant correlations between the HRS-SR-J and social desirability, the HRS-SR-J was not strongly affected by social desirability. In addition, it also had a good convergent validity with the Japanese version of the Saving Inventory-Revised (SI-R-J and the hoarding subscale of the Obsessive-Compulsive Inventory, while having a significantly weaker correlation with the five subscales of the Obsessive-Compulsive Inventory, except for the hoarding subscale. In addition, the

  13. ESA Press Event: See Mars Express before its departure to the Red Planet

    Science.gov (United States)

    2002-08-01

    There will be ten participants: four ESA astronauts (Pedro Duque, Leopold Eyharts, Paolo Nespoli and Thomas Reiter), four Japanese astronauts from NASDA (Takao Doi, Koichi Wakata, Satoshi Furukawa and Aikihido Hoshide) and two NASA astronauts (Nicole Passonno Stott and Stephanie D. Wilson). The main objective of this training session is to prepare the astronauts for the tasks they will have to perform when the Japanese experiment module (JEM) and ESA's Columbus laboratory are docked with the core of the International Space Station over the years ahead. After completing their training and certification, the astronauts will be assigned to long-duration missions to the ISS. The advanced training at the EAC will focus on the Columbus systems and the Automated Transfer Vehicle (ATV). It will consist of 24 classroom lectures on the Columbus and ATV systems and 4 on payloads, and 2 sessions in the Columbus Trainer. Instructors are being provided by Astrium for the Columbus systems and Alenia Spazio for the ATV, with ESA/EAC staff as mentors for the Columbus payloads. The astronauts are scheduled to visit Astrium in Bremen on 30 August to get acquainted with the flight unit of the Columbus laboratory module currently undergoing integration. This group of astronauts started their advanced training in April 2001 at NASA's Johnson Space Center (JSC), Houston, where they attended a first course on the US segment of the International Space Station. This was followed by training on the JEM system at NASDA's Tsukuba Space Center, Japan, in December 2001 - January 2002 and additional training at the JSC in May 2002. At the beginning of next year the group will be returning to Tsukuba for training on Japanese payloads. Hands-on sessions on Columbus Payload Training Models are scheduled for the second half of 2003, again at ESA's European Astronaut Centre. On Thursday 5 September, between 16:30 and 18:30 hrs, the astronauts and other ESA specialists will be available for interviews

  14. Willingness to Pay for Elderly Telecare Service Using the Internet and Digital Terrestrial Broadcasting.

    Science.gov (United States)

    Kaga, Satoshi; Suzuki, Teppei; Ogasawara, Katsuhiko

    2017-10-24

    younger age group. However, WTP surveys need to be carefully conducted to minimize the sampling bias and allocate accurate structure of gender distribution. ©Satoshi Kaga, Teppei Suzuki, Katsuhiko Ogasawara. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 24.10.2017.

  15. The association between suicide risk and self-esteem in Japanese university students with major depressive episodes of major depressive disorder

    Directory of Open Access Journals (Sweden)

    Mitsui N

    2014-05-01

    Full Text Available Nobuyuki Mitsui,1 Satoshi Asakura,1,2 Yusuke Shimizu,1 Yutaka Fujii,1 Atsuhito Toyomaki,1 Yuki Kako,1 Teruaki Tanaka,1 Nobuki Kitagawa,3 Takeshi Inoue,1 Ichiro Kusumi1 1Department of Psychiatry, Hokkaido University Graduate School of Medicine, 2Health care center of Hokkaido University, Kita-ku, Sapporo, 3Department of Clinical Social Work, Health Sciences University of Hokkaido School of Nursing and Social Services, Tobetsu, Ishikari, Japan Background: The suicide risk among young adults is related to multiple factors; therefore, it is difficult to predict and prevent suicidal behavior. Aim: We conducted the present study to reveal the most important factors relating to suicidal ideation in Japanese university students with major depressive episodes (MDEs of major depressive disorder (MDD. Methods: The subjects were 30 Japanese university students who had MDEs of MDD, and were aged between 18 and 26 years old. They were divided into two groups – without suicide risk group (n=15, and with suicide risk group (n=15 – based on the results of the Mini-International Neuropsychiatric Interview. Additionally, healthy controls were recruited from the same population (n=15. All subjects completed the self-assessment scales including the Beck Depression Inventory 2nd edition (BDI-II, the Beck Hopelessness Scale (BHS, Rosenberg's Self-Esteem Scale (RSES, and SF-36v2TM (The Medical Outcomes Study 36-item short-form health survey version 2, and they were all administered a battery of neuropsychological tests. Results: The RSES score of the suicide risk group was significantly lower than the RSES score of the without suicide risk group, whereas the BDI-II score and the BHS score were not significantly different between the two groups. The mean social functioning score on the SF-36v2 of the with suicide risk group was significantly lower than that of the without suicide risk group. Conclusion: The individual's self-esteem and social functioning may play an

  16. 2003 RIA R AND D WORKSHOP.

    Energy Technology Data Exchange (ETDEWEB)

    OZAKI, S.ET AL.

    2003-08-26

    The 2003 RIA R&D Workshop was held on August 26-28, 2003 at the Four Points Sheraton Hotel in Bethesda, Maryland. This Workshop was chaired by Satoshi Ozaki of BNL and sponsored by the Nuclear Physics Division of DOE, with the help of Oak Ridge Institute for Science and Education (ORISE). The purpose of this workshop was to understand the present status of R&D efforts for RIA, to evaluate the needs for further R&D, and to identify opportunities for international collaborations. The workshop examined and documented the current pre-conceptual design for RIA, identifying areas where decisions on technical options remain. The status of the current RIA R&D program was documented, recognizing areas where efforts were needed in light of what had been learned. The ongoing and planned R&D activities for operating and planned rare-isotope facilities were presented, enabling the workshop to be a venue to develop coordinated R&D efforts of mutual benefit to U.S. and international efforts. The scientific program for the first day (August 26, 2003) consisted mostly of invited talks presented by major research groups involved in RIA and other RI beam facilities. The talks included those covering: Science of RIA and the RIA Facility Performance Requirements; The Reference RIA Facility Pre-CDR design that was used for the NSAC cost exercise (M. Harrison Sub-Panel) in January 2001; New or latest perspectives on the RIA design at ANL & MSU; and RI Beam facility plans and overview of the R&D activities at overseas laboratories. The second day (August 27, 2003) was devoted to contributed talks on continuing R&D, including that which had been supported by DOE RIA R&D funds. The third day (August 28, 2003) began with open panel discussions in the morning, including further input from participants. The panel members discussed the present status of the RIA planning and R&D needs in a closed session for the rest of the day, and then worked on report planning and writing. This Workshop

  17. Associations between deepness of response and clinical outcomes among Japanese patients with metastatic colorectal cancer treated with second-line FOLFIRI plus cetuximab

    Directory of Open Access Journals (Sweden)

    Osumi H

    2015-08-01

    Full Text Available Hiroki Osumi, Satoshi Matsusaka, Mitsukuni Suenaga, Eiji Shinozaki, Nobuyuki Mizunuma Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan Background: In the FIRE-3 trial, overall survival (OS was significantly longer in patients treated with FOLFIRI plus cetuximab (C-mab than in those treated with FOLFIRI plus bevacizumab (Bev, but progression-free survival (PFS was not significantly different. This may be associated with the deepness of response (DpR in patients treated with FOLFIRI plus C-mab. We aimed to evaluate the relationship between clinical outcome and DpR in metastatic colorectal cancer (mCRC patients treated with second-line FOLFIRI plus C-mab.Methods: A total of 112 patients with histopathologically confirmed mCRC treated with second-line FOLFIRI in combination with C-mab (N=42 or Bev (N=70 were retrospectively enrolled between October 2008 and June 2013. The relationship between DpR and clinical outcome in patients treated with FOLFIRI plus C-mab or Bev was determined.Results: Forty-two patients treated with FOLFIRI plus C-mab had a mean DpR of 6.1% (interquartile range: -13.7%, 20.8% and a minimum DpR of -62.7%. On the other hand, 70 patients treated with FOLFIRI plus Bev had a mean DpR of 0% (interquartile range: -16%, 10% and a minimum DpR of -111%. DpR ≥30% was associated with significantly longer OS and PFS when compared with DpR ≤30% in patients given FOLFIRI plus C-mab. DpR (≥30% was independently associated with prolongation of OS and PFS. In patients treated with FOLFIRI plus C-mab, there was a moderate positive correlation between DpR and clinical outcomes (OS: r=0.51, P<0.001; PFS: r=0.54, P<0.001.Conclusion: FOLFIRI plus C-mab yielded a stronger correlation between DpR and clinical outcomes. These results indicate the potential of DpR as a new measure of efficacy in mCRC patients treated with second-line chemotherapy plus C-mab. Keywords: deepness of

  18. Anticoagulant therapy for venous thromboembolism detected by Doppler ultrasound in patients with metastatic colorectal cancer receiving bevacizumab

    Directory of Open Access Journals (Sweden)

    Suenaga M

    2015-01-01

    Full Text Available Mitsukuni Suenaga, Nobuyuki Mizunuma, Eiji Shinozaki, Satoshi Matsusaka, Masato Ozaka, Mariko Ogura, Keisho Chin, Toshiharu Yamaguchi Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan Background: Doppler ultrasound imaging is useful for management of venous thromboembolism associated with a subclavicular implantable central venous access system in patients receiving bevacizumab (Bev. We investigated the efficacy and safety of our anticoagulant regimen based on Doppler findings.Methods: Patients aged ≤75 years with metastatic colorectal cancer, no history of thromboembolism, and no prior use of Bev received chemotherapy plus Bev. Doppler ultrasound imaging of the deep venous system to detect thrombosis was performed after the first course of Bev and repeated after the third course in patients with asymptomatic thrombosis. Indications for anticoagulant therapy in patients with asymptomatic thrombosis were as follows: enlarging thrombus (E, thrombus >40 mm in diameter (S, thrombus involving the superior vena cava (C, and decreased blood flow (V.Results: Among 79 patients enrolled in this study, asymptomatic thrombosis was detected in 56 patients (70.9% by Doppler ultrasound imaging after the first course of Bev and there was no thrombus in 23 patients (29.1%. Of these 56 patients, 11 (19.6% received anticoagulant therapy with warfarin, including eight after the first course and three after follow-up imaging. S + V was observed in four of 11 patients (36.4%, as well as V in two (18.2%, S + V + C in one (9.1%, E + S + V in one (9.1%, E + C in one (9.1%, E in one (9.1%, and C in one (9.1%. All patients resumed chemotherapy, including seven who resumed Bev. Improvement or stabilization of thrombi was achieved in ten patients (90.9%. Only one patient had symptomatic thromboembolism. Mild bleeding due to anticoagulant therapy occurred in six patients (54.5%, but there were no treatment

  19. A data-capture system for post-marketing surveillance of drugs that integrates with hospital electronic health records

    Directory of Open Access Journals (Sweden)

    Yamamoto K

    2011-04-01

    Full Text Available Keiichi Yamamoto1, Shigemi Matsumoto2, Kazuhiro Yanagihara2, Satoshi Teramukai1, Masanori Fukushima1,2,31Department of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto, Japan; 2Outpatient Oncology Unit, Kyoto University Hospital, Kyoto, Japan; 3Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, JapanPurpose: In conventional clinical studies, the cost of data management for the purposes of quality control tend to be high and collecting paper-based case report forms (CRFs can be burdensome, because paper-based CRFs must be developed and filled out for each clinical study protocol. Use of electronic health records (EHRs for this purpose could reduce costs and improve data quality in clinical studies. Kyoto University Hospital launched an EHR system in January 2005. At the same time, a replicate of that database was established for other purposes. At the Outpatient Oncology Unit of Kyoto University Hospital we developed a data-capture system that includes a cancer clinical database system and a data warehouse for outcomes studies. This system allows us to accumulate data at low cost and apply it to various uses in clinical or outcomes studies. Here we report on the application of this system to the post-marketing surveillance of drugs.Methods: We evaluated the availability of this system and identified problems for future development. With this system investigators can register cases for post-marketing surveillance, and the registered cases are listed on a screen. When CRFs for a particular case are required, data can be extracted from the list and CRFs are produced in PDF format.Results and conclusion: In this study we confirmed the applicability of our new system to post-marketing surveillance in providing prompt and efficient data exchange. We expect it to reduce the cost of data management and analysis and to improve the quality of data in post

  20. Comparative effect of clopidogrel plus aspirin and aspirin monotherapy on hematological parameters using propensity score matching

    Directory of Open Access Journals (Sweden)

    Hayasaka M

    2013-02-01

    Full Text Available Masatoshi Hayasaka,1 Yasuo Takahashi,2 Yayoi Nishida,2 Yoshikazu Yoshida,1 Shinji Hidaka,3 Satoshi Asai41Department of Pharmacy, Nihon University Itabashi Hospital, Tokyo, 2Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, 3Laboratory of Pharmaceutical Regulatory Science, Department of Pharmacy, School of Pharmacy, Nihon University, Chiba, 4Division of Pharmacology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, JapanBackground: Clopidogrel and aspirin are antiplatelet agents that are recommended to reduce the risk of recurrent stroke and other cardiovascular events. Dual antiplatelet therapy with clopidogrel and aspirin has been shown to increase the risk of hemorrhage, but the effects of the drugs on laboratory parameters have not been well studied in real-world clinical settings. Therefore, we evaluated and compared the effects of combination therapy with clopidogrel plus aspirin and aspirin monotherapy on laboratory parameters.Methods: We used data from the Nihon University School of Medicine Clinical Data Warehouse obtained between November 2004 and May 2011 to identify cohorts of new users (n = 130 of clopidogrel (75 mg/day plus aspirin (100 mg/day and a propensity score matched sample of new users (n = 130 of aspirin alone (100 mg/day. We used a multivariate regression model to compare serum levels of creatinine, aspartate aminotransferase, and alanine aminotransferase, as well as hematological parameters including hemoglobin level, hematocrit, and white blood cell, red blood cell, and platelet counts up to 2 months after the start of administration of the study drugs.Results: There were no significant differences for any characteristics and baseline laboratory parameters between users of clopidogrel plus aspirin and users of aspirin alone. Reductions in white blood cell and red blood cell counts, hemoglobin levels, and

  1. Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population

    Directory of Open Access Journals (Sweden)

    Kawamura S, Maesawa C, Nakamura K, Nakayama K, Morita M, Hiruma Y, Yoshida T, Sakai A, Masuda T

    2011-11-01

    Full Text Available Satoshi Kawamura1, Chihaya Maesawa2, Koji Nakamura1, Kazuhiko Nakayama1, Michiaki Morita1, Yohei Hiruma1, Tomoyuki Yoshida3, Akio Sakai3, Tomoyuki Masuda41Department of Psychiatry, Tokyo Jikei University school of Medicine, Tokyo, Japan; 2Department of Tumor Biology, Division of Bioscience, center for Advanced Medical science, Iwate Medical University school of Medicine, Morioka, Japan; 3Department of Neuropsychiatry, Iwate Medical University school of Medicine, Morioka, Japan; 4Department of Pathology, Iwate Medical University school of Medicine, Morioka, JapanAbstract: Polycystic ovary syndrome (PCOS is a common lifestyle-related endocrinopathy in women of reproductive age and is associated with several mental health problems. We examined the genotypic distributions of IRS-1 Gly972Arg and CYP11B2 -344T/C, which were previously described as influencing PCOS, and assayed the serum levels of interleukin-6 (IL-6 and tumor necrosis factor-alpha (TNF-α, in a set of female patients with borderline personality disorder (BPD with comorbid major depressive disorder (MDD (n = 50 and age-matched control subjects (n = 100, to investigate the predisposition for BPD with MDD. The results showed that the patients were more frequently IRS-1 972Arg variant allele carriers (P = 0.013; OR 6.68; 95% CI = 1.30-34.43 and homozygous for the CYP11B2 -344C variant allele (P = 0.022; OR = 3.32; 95% CI = 1.18-9.35 than the control subjects. The IL-6 level was significantly higher in the patients than in the controls (P < 0.0001. There was no significant difference in the serum TNF-α level between patients with BPD with MDD and the healthy comparison group (P = 0.5273. In conclusion, the predisposition for BPD with MDD is associated with that for PCOS, in the female Japanese population. An elevated serum IL-6 level is considered to be a possible biomarker of BPD with MDD.Keywords: borderline personality disorder, depression, polycystic ovary syndrome, genetic

  2. 2003 RIA R AND D WORKSHOP

    International Nuclear Information System (INIS)

    OZAKI, S.

    2003-01-01

    The 2003 RIA R and D Workshop was held on August 26-28, 2003 at the Four Points Sheraton Hotel in Bethesda, Maryland. This Workshop was chaired by Satoshi Ozaki of BNL and sponsored by the Nuclear Physics Division of DOE, with the help of Oak Ridge Institute for Science and Education (ORISE). The purpose of this workshop was to understand the present status of R and D efforts for RIA, to evaluate the needs for further R and D, and to identify opportunities for international collaborations. The workshop examined and documented the current pre-conceptual design for RIA, identifying areas where decisions on technical options remain. The status of the current RIA R and D program was documented, recognizing areas where efforts were needed in light of what had been learned. The ongoing and planned R and D activities for operating and planned rare-isotope facilities were presented, enabling the workshop to be a venue to develop coordinated R and D efforts of mutual benefit to U.S. and international efforts. The scientific program for the first day (August 26, 2003) consisted mostly of invited talks presented by major research groups involved in RIA and other RI beam facilities. The talks included those covering: Science of RIA and the RIA Facility Performance Requirements; The Reference RIA Facility Pre-CDR design that was used for the NSAC cost exercise (M. Harrison Sub-Panel) in January 2001; New or latest perspectives on the RIA design at ANL and MSU; and RI Beam facility plans and overview of the R and D activities at overseas laboratories. The second day (August 27, 2003) was devoted to contributed talks on continuing R and D, including that which had been supported by DOE RIA R and D funds. The third day (August 28, 2003) began with open panel discussions in the morning, including further input from participants. The panel members discussed the present status of the RIA planning and R and D needs in a closed session for the rest of the day, and then worked on report

  3. Retrospective study on the efficacy of a low-carbohydrate diet for impaired glucose tolerance

    Directory of Open Access Journals (Sweden)

    Maekawa S

    2014-06-01

    Full Text Available Satoshi Maekawa,1 Tetsuya Kawahara,2 Ryosuke Nomura,1 Takayuki Murase,1 Yasuyoshi Ann,1 Masayuki Oeholm,1 Masaru Harada31Department of Gastroenterology and Hepatology, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Japan Labor Health and Welfare Organization, Niigata Rosai Hospital, Joetsu, Niigata, Japan; 3Third Department of Internal Medicine, University of Occupational and Environmental Health, Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka, JapanBackground: In recent years, the number of people with impaired glucose tolerance (IGT has increased steadily worldwide. It is clear that the prevention of diabetes is important from the perspective of public health, medical care, and economics. It was recently reported that a low-carbohydrate diet (LCD is useful for achieving weight loss and glycemic control, but there is no information about the effects of the LCD on IGT. We designed a 7-day in-hospital educational program focused on the LCD for IGT.Methods: The subjects were 72 patients with IGT (36 in the LCD group and 36 in the control group who were enrolled from April 2007–March 2012 and followed for 12 months. We retrospectively compared the LCD group with the control group.Results: In 69.4% of the LCD group, blood glucose was normalized at 12 months and the 2-hour plasma glucose level in the oral glucose tolerance test (OGTT was reduced by 33 mg/dL. In addition, the incidence of diabetes was significantly lower in the LCD group than in the control group at 12 months (0% versus 13.9%, P=0.02. The LCD group showed a significant decrease in fasting plasma glucose, hemoglobin A1c, the homeostasis model of assessment of insulin resistance value, body weight and serum triglycerides (TGs at 12 months, while there was a significant increase of the serum high-density lipoprotein (HDL cholesterol level.Conclusion: The LCD is effective for normalizing blood glucose and preventing progression to type 2 diabetes in

  4. The update of resist outgas testing for metal containing resists at EIDEC

    Science.gov (United States)

    Shiobara, Eishi; Mikami, Shinji

    2017-10-01

    work was supported by Ministry of Economy, Trade and Industry (METI) and New Energy and Industrial Technology Development Organization (NEDO). [1] Eishi Shiobara, Shinji Mikami, Satoshi Tanaka, International Symposium on EUV Lithography, Hiroshima, Japan, P-RE-01, (2016). [2] Mark van de Kerkhof, Hans Jasper, Leon Levasier, Rudy Peeters, Roderik van Es, Jan-Willem Bosker, Alexander Zdravkov, Egbert Lenderink, Fabrizio Evangelista, Par Broman, Bartosz Bilski, Thorsten Last, Proc. of SPIE Vol. 10143, 101430D (2017). [3] Oktay Yildirim, Elizabeth Buitrago, Rik Hoefnagels, Marieke Meeuwissen, Sander Wuister, Gijsbert Rispens, Anton van Oosten, Paul Derks, Jo Finders, Michaela Vockenhuber, Yasin Ekinci, Proc. of SPIE Vol. 10143, 101430Q (2017).

  5. Evaluation of atherosclerotic lesions using dextran- and mannan–dextran-coated USPIO: MRI analysis and pathological findings

    Directory of Open Access Journals (Sweden)

    Mukaisho K

    2012-05-01

    Full Text Available Keiko Tsuchiya1, Norihisa Nitta1, Akinaga Sonoda1, Ayumi Nitta-Seko1, Shinichi Ohta1, Masashi Takahashi1, Kiyoshi Murata1, Kenichi Mukaisho2, Masashi Shiomi3, Yasuhiko Tabata4, Satoshi Nohara51Department of Radiology, 2Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, 3Institute for Experimental Animals, Kobe University School of Medicine, Kobe, Hyogo, 4Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, 5Nagoya Research Laboratory, Meito Sangyo, Kiyosu, Aichi, JapanAbstract: Magnetic resonance imaging (MRI can detect atherosclerotic lesions containing accumulations of ultrasmall superparamagnetic iron oxides (USPIO. Positing that improved USPIO with a higher affinity for atherosclerotic plaques would yield better plaque images, we performed MRI and histologic studies to compare the uptake of dextran- and mannan–dextran-coated USPIO (D-USPIO and DM-USPIO, respectively by the atherosclerotic walls of rabbits. We intravenously injected atherosclerotic rabbits with DM-USPIO (n = 5 or D-USPIO (n = 5. Two rabbits were the controls. The doses delivered were 0.08 (dose 1 (n = 1, 0.4 (dose 2 (n = 1, or 0.8 (dose 3 (n = 3 mmol iron/Kg. The dose 3 rabbits underwent in vivo contrast-enhanced magnetic resonance angiography (MRA before and 5 days after USPIO administration. Afterwards, all animals were euthanized, the aortae were removed and subjected to in vitro MRI study. The signal-to-noise ratio (SNR of the aortic wall in the same region of interest (ROI was calculated in both in vivo and in vitro studies. Histological assessment through measurement of iron-positive regions in Prussian blue-stained specimens showed that iron-positive regions were significantly larger in rabbits injected with DM- rather than D-USPIO (P < 0.05 for all doses. In vivo MRA showed that the SNR-reducing effect of DM- was greater than that of D-USPIO (P < 0.05. With in vitro MRI scans, SNR was significantly

  6. A retrospective study of neoadjuvant chemotherapy plus radical hysterectomy versus radical hysterectomy alone in patients with stage II cervical squamous cell carcinoma presenting as a bulky mass

    Directory of Open Access Journals (Sweden)

    Takatori E

    2016-09-01

    Full Text Available Eriko Takatori, Tadahiro Shoji, Anna Takada, Takayuki Nagasawa, Hideo Omi, Masahiro Kagabu, Tatsuya Honda, Fumiharu Miura, Satoshi Takeuchi, Toru Sugiyama Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate, Japan Objective: In order to evaluate the usefulness of neoadjuvant chemotherapy (NAC for stage II cervical squamous cell carcinoma with a bulky mass, we retrospectively compared patients receiving NAC followed by radical hysterectomy (RH; NAC group with patients who underwent RH without NAC (Ope group. Patients and methods: The study period was from June 2002 to March 2014. The subjects were 28 patients with a stage II bulky mass in the NAC group and 17 such patients in the Ope group. The chi-square test was used to compare operative time, volume of intraoperative blood loss, use of blood transfusion, and time from surgery to discharge between the two groups. Moreover, the log-rank test using the Kaplan–Meier method was performed to compare disease-free survival (DFS and overall survival (OS between the groups. Results: There were no statistically significant differences between the two groups in operative time, volume of intraoperative blood loss, or use of blood transfusion. However, the time from surgery to discharge was 18 days (14–25 days in the NAC group and 25 days (21–34 days in the Ope group; the patients in the NAC group were discharged earlier (P=0.032. The hazard ratio for DFS in the NAC group as compared with that in the Ope group was 0.36 (95% CI 0.08–0.91, and the 3-year DFS rates were 81.2% and 41.0%, respectively (P=0.028. Moreover, the hazard ratio for OS was 0.39 (95% CI 0.11–1.24, and the 3-year OS rates were 82.3% and 66.4%, respectively (P=0.101. Conclusion: NAC with cisplatin and irinotecan was confirmed to prolong DFS as compared with RH alone. The results of this study suggest that NAC might be a useful adjunct to surgery in the treatment of stage II squamous

  7. Prevalence and characteristics of asthma–COPD overlap syndrome identified by a stepwise approach

    Directory of Open Access Journals (Sweden)

    Inoue H

    2017-06-01

    Full Text Available Hiromasa Inoue,1 Takahide Nagase,2 Satoshi Morita,3 Atsushi Yoshida,4 Tatsunori Jinnai,4 Masakazu Ichinose5 1Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, 2Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 3Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, 4Medical Department, AstraZeneca K.K., Osaka, 5Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan Background and objective: There is increasing recognition of asthma–COPD overlap syndrome (ACOS, which shares some features of both asthma and COPD; however, the prevalence and characteristics of ACOS are not well understood. The aim of this study was to investigate the prevalence of ACOS among patients with COPD and its characteristics using a stepwise approach as stated in the recent report of the Global Initiative for Asthma (GINA and the Global Initiative for Chronic Obstructive Lung Disease (GOLD. Methods: This multicenter, cross-sectional, observational study enrolled outpatients who were receiving medical treatment for COPD. Clinical data, including spirometry results, were retrieved from medical records. For symptom assessment, patients were asked to complete the Clinical COPD questionnaire and the modified British Medical Research Council questionnaire. Results: Of the 1,008 patients analyzed, 167 (16.6% had syndromic features of ACOS. Of the total number of patients, 93 and 42 (9.2% and 4.2% also had a predefined clinical variability of ≥12%/≥200 mL and ≥12%/≥400 mL in forced expiratory volume in 1 second (FEV1, respectively, and therefore were identified as having ACOS. Conversely, the number of patients who had either syndromic or spirometric feature of ACOS was 595 (59.0%, ≥12%/≥200 mL FEV1 clinical variability, and 328 patients (32.5%, ≥12%/≥400 m

  8. Peer review statement

    Science.gov (United States)

    2010-08-01

    , HeidenheimGermany Albert RUPRECHTUniversity of StuttgartGermany Michel SABOURINAlstom Hydro Canada Inc.Canada Rudolf SCHILLINGTechnische Universität MünchenGermany Qing-Hua SHIDong Fang Electrical Machinery Co.China Aleš SKOTAKCKD Blansko Engineering, a. s.Czech Republic Romeo F. SUSAN-RESIGAPolitehnica University of TimisoaraRomania Geraldo TIAGO FILHOUniversidade Federal de ItajubaBrazil Yoshinobu TSUJIMOTOOsaka UniversityJapan Bart van ESCHTechnische Universiteit EindhovenNetherland Thi C. VUAndritz Hydro Ltd, QuebecCanada Satoshi WATANABEKyushu University, FukuokaJapan Yulin WUTsinghua University, BeijingChina The reviewing process was organized in several steps. First, the 238 abstracts submitted for the symposium were reviewed, and 197 were accepted, with 30 abstracts having recommendations. Second, the authors have submitted 152 full-length papers, and each paper has been reviewed by two referees. The recommendations have been sent back to the authors, in order to prepare the final form or the paper. Third, 118 papers have been received in final form, accounting for the referees recommendations, to be included in the proceedings and to be presented at the symposium.

  9. A phase I/II study of biweekly capecitabine and irinotecan plus bevacizumab as second-line chemotherapy in patients with metastatic colorectal cancer

    Directory of Open Access Journals (Sweden)

    Suenaga M

    2015-03-01

    Full Text Available Mitsukuni Suenaga,1 Nobuyuki Mizunuma,1 Satoshi Matsusaka,1 Eiji Shinozaki,1 Masato Ozaka,1 Mariko Ogura,1 Keisho Chin,1 Toshiharu Yamaguchi2 1Department of Gastroenterology, 2Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo, Japan Background: Triweekly capecitabine plus irinotecan (XELIRI is not completely regarded as a valid substitute for fluorouracil, leucovorin, and irinotecan (FOLFIRI in metastatic colorectal cancer (mCRC because of the potential for greater toxicity. We conducted a phase I/II study to assess the efficacy and safety of biweekly XELIRI plus bevacizumab (BV as second-line chemotherapy for mCRC.Methods: Patients with mCRC who had received prior chemotherapy including oxaliplatin and BV and had a UGT1A1 genotype of wild-type or heterozygous for UGT1A1*6 or *28 were eligible for this study. Treatment comprised capecitabine 1,000 mg/m2 twice daily from the evening of day 1 to the morning of day 8, intravenous irinotecan on day 1, and BV 5 mg/kg on day 1 every 2 weeks. The phase I study consisted of two steps (irinotecan 150 and 180 mg/m2, and dose-limiting toxicity was assessed during the first treatment cycle. The primary endpoint of the phase II study was progression-free survival (PFS.  Results: The recommended dose of irinotecan was determined to be 180 mg/m2 in the phase I study. Between November 2010 and August 2013, 44 patients were enrolled in phase II. The patients’ characteristics were as follows (N=44: median age, 60 years (range 32–80; male/female, 21/23; and UGT1A1 wild-type/heterozygous, 29/15. The median PFS was 6.8 months (95% confidence interval, 5.3–8.2 months, and the primary endpoint was met. Median overall survival was 18.3 months. The response rate was 22.7%. There was no significant difference in PFS or overall survival according to UGT1A1 status. Grade 3 or higher adverse events were mainly neutropenia in six

  10. 6th conference on Advances in Optoelectronics and Micro/nano-optics

    International Nuclear Information System (INIS)

    2017-01-01

    would like to thank all participants of this conference, and particularly the authors of all accepted papers for their high quality and fruitful contributions. We do hope that this volume will be beneficial for readers to their future research endeavours and careers. We also gratefully acknowledge tremendous efforts and dedication of many individuals and all the Editorial Board members in IOP Publishing for their support in producing the proceedings of this event. Sincerely, Yiping Cui Conference Co-Chair CONFERENCE OFFICIALS Conference Co-Chairs Yiping Cui Southeast University, China Xiaocong Yuan Shenzhen University, China Shining Zhu Nanjing University, China Executive Chair Zhuyuan Wang Southeast University, China Technical Program Committee Guanghui Chen China Electronics Technology Group Corporation, China Yiping Cui Southeast University, China Qihuang Gong Peking University, China Min Gu Swinburne University of Technology, Australia Satoshi Kawata Osaka University, Japan Gong-Ru Lin National Taiwan University, Taiwan, China Xu Liu Zhejiang University, China Yanqing Lu Nanjing University, China Ting Mei Northwestern Polytechnical University, China Min Qiu Zhejiang University, China Marek Samoc Wroclaw University of Technology, Poland Colin Sheppard Italian Institute of Technology, Italy Charles Surya Hong Kong Polytechnic University, China Katarina Svanberg Lund University, Sweden Sune Svanberg Lund University, Sweden Jinghua Teng IMRE, Singapore Dinping Tsai Academia Sinica, Taiwan, China Zhuyuan Wang Southeast University, China Jingjun Xu Nankai University, China Baoli Yao Xi’an Institute of Optics and Precision Mechanics, China Xiaocong Yuan Shenzhen University, China Qiwen Zhan University of Dayton, USA Shining Zhu Nanjing University, China (paper)

  11. Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305 in patients with advanced solid tumors

    Directory of Open Access Journals (Sweden)

    Wu H

    2015-02-01

    Full Text Available Huali Wu,1 Jeffrey R Infante,2 Vicki L Keedy,3 Suzanne F Jones,2 Emily Chan,3 Johanna C Bendell,2 Wooin Lee,4 Whitney P Kirschbrown,1 Beth A Zamboni,5 Satoshi Ikeda,6 Hiroshi Kodaira,6 Mace L Rothenberg,3 Howard A Burris III,2 William C Zamboni1,7–9 1UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 2Sarah Cannon Research Institute/Tennessee Oncology, PLLC, 3Vanderbilt University, Nashville, TN, 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 5Department of Mathematics, Carlow University, Pittsburgh, PA, USA; 6Yakult Honsha Co., Ltd., Medical Development Department, Tokyo, Japan; 7UNC Lineberger Comprehensive Cancer Center, 8UNC Institute for Pharmacogenomics and Individualized Therapy, 9Carolina Center for Cancer Nanotechology Excellence, University of North Carolina, Chapel Hill, NC, USA Abstract: IHL-305 is a PEGylated liposomal formulation of irinotecan (CPT-11. The objective of this study was to evaluate the factors associated with interpatient variability in the pharmacokinetics and pharmacodynamics of IHL-305 in patients with advanced solid tumors. IHL-305 was administered intravenously once every 4 weeks as part of a Phase I study. Pharmacokinetic studies of the liposomal sum total CPT-11, released CPT-11, SN-38, SN-38G, 7-ethyl-10-[4-N-(5-aminopentanoic acid-1-piperidino]-carbonyloxycamptothecin, and 7-ethyl-10-[4-amino-1-piperidino]-carbonyloxycamptothecin in plasma were performed. Noncompartmental and compartmental pharmacokinetic analyses were conducted using pharmacokinetic data for sum total CPT-11. The pharmacokinetic variability of IHL-305 is associated with linear and nonlinear clearance. Patients whose age and body composition (ratio of total body weight to ideal body weight [TBW/IBW] were greater than the median age and TBW/IBW of the study had a 1.7-fold to 2.6-fold higher ratio of released CPT-11 area under the concentration versus time

  12. Alteration of Organic Compounds in Small Bodies and Cosmic Dusts by Cosmic Rays and Solar Radiation

    Science.gov (United States)

    Kobayashi, Kensei; Kaneko, Takeo; Mita, Hajime; Obayashi, Yumiko; Takahashi, Jun-ichi; Sarker, Palash K.; Kawamoto, Yukinori; Okabe, Takuto; Eto, Midori; Kanda, Kazuhiro

    2012-07-01

    amino acids. Complex amino acid precursors with high molecular weights could be formed in simulated dense cloud environments. They would have been altered in the early solar system by irradiation with soft X-rays from the young Sun, which caused increase of hydrophobicity of the organics of interstellar origin. They were taken up by parent bodies of meteorites or comets, and could have been delivered to the Earth by meteorites, comets and cosmic dusts. Cosmic dusts were so small that they were directly exposed to the solar radiation, which might be critical for the survivability of organics in them. In order to evaluate the roles of space dusts as carriers of bioorganic compounds to the primitive Earth, we are planning the Tanpopo Mission, where collection of cosmic dusts by using ultra low-density aerogel, and exposure of amino acids and their precursors for years are planned by utilizing the Japan Experimental Module / Exposed Facility of the ISS [2]. The mission is now scheduled to start in 2013. We thank Dr. Katsunori Kawasaki of Tokyo Institute of Technology, and Dr. Satoshi Yoshida of National Institute of Radiological Sciences for their help in particles irradiation. We also thank to the members of JAXA Tanpopo Working Group (PI: Prof. Akihiko Yamagishi) for their helpful discussion. [1] K. Kobayashi, et al., in ``Astrobiology: from Simple Molecules to Primitive Life,'' ed. by V. Basiuk, American Scientific Publishers, Valencia, CA, (2010), pp. 175-186. [2] K. Kobayashi, et al., Trans. Jpn. Soc. Aero. Space Sci., in press (2012).

  13. Exercise habituation is effective for improvement of periodontal disease status: a prospective intervention study

    Directory of Open Access Journals (Sweden)

    Omori S

    2018-03-01

    Full Text Available Shoei Omori,1,2 Fumihiko Uchida,3 Sechang Oh,4,5 Rina So,6 Takehiko Tsujimoto,7 Toru Yanagawa,8 Satoshi Sakai,4 Junichi Shoda,4,5 Kiyoji Tanaka,9 Hiroki Bukawa8 1Oral and Maxillofacial Surgery, Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan; 2Department of Dental Oral Surgery, Kitaibaraki City Hospital, Kitaibaraki, Ibaraki, Japan; 3Department of Oral and Maxillofacial Surgery, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan; 4Department of Medical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; 5The Center of Sports Medicine and Health Sciences, Tsukuba University Hospital, Tsukuba, Ibaraki, Japan; 6Research Center for Overwork-Related Disorders, National Institute of Occupational Safety and Health, Kawasaki, Kanagawa, Japan; 7Department of Sports Medicine, Faculty of Human Sciences, Shimane University, Matsue, Shimane, Japan; 8Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; 9Department of Sports Medicine, Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan Background and purpose: Periodontal disease is closely related to lifestyle-related diseases and obesity. It is widely known that moderate exercise habits lead to improvement in lifestyle-related diseases and obesity. However, little research has been undertaken into how exercise habits affect periodontal disease. The purpose of this study was to examine the effect of exercise habits on periodontal diseases and metabolic pathology. Methods: We conducted a prospective intervention research for 12 weeks. The subjects were 71 obese men who participated in an exercise and/or dietary intervention program. Fifty subjects were assigned to exercise interventions (exercise intervention group and 21 subjects were assigned to dietary interventions (dietary intervention group. This research was

  14. Supermodernity, distraction, schizophrenia: walking in Tokyo & Hong Kong.

    Directory of Open Access Journals (Sweden)

    Ian Ho-Yin Fong

    2014-12-01

    Full Text Available The architecture in a supermodern city has no sense of the place where it is located. This paper discusses how schizophrenia and distraction, through walking, respond to supermodernity by referring to how three dislocated subjects, Fumiya Takemura, Aiichiro Fukuhara and Fai in Tokyo and Hong Kong, are respectively depicted in the novel, Adrift in Tokyo written by Fujita Yoshinaga in 1999, with a film adaptation by Satoshi Miki (2007, and the film To Live and Die in Mongkok directed by Wong Jing in 2009. It suggests that Hong Kong is more supermodern than Tokyo. After his release from prison, Fai in To Live and Die in Mongkok finds that Mongkok is a completely different place from the one in which he used to live. The living conditions are no better than those in the prison. He hallucinates about the past. Adrift in Tokyo can be read as a story about walking. Fukuhara, a debt collector, killed his wife; before surrendering to the police, he orders his debtor, Takemura, to walk with him in Tokyo in order to re-experience the walks he enjoyed with his wife. If Takemura agrees, the debt can be paid off. This paper discusses how the repressed heterogeneous time and place can be approached by walking in a way that the rhythm of life can be (re-experienced; in other words, when the body moves forward physically, the past appears as specter haunting the walker. This paper discusses how Adrift in Tokyo and To Live and Die in Mongkok read cities in distractive and schizophrenic ways. In the film version of Adrift in Tokyo, Takemura’s failed relationship with his father may unconsciously drive him to walk with Fukuhara. The novel may imply that the lost relationship with his mother drives him to walk. The film and the novel both address a kind of locality which should be inseparable from the birth parents. To Live and Die in Mongkok suggests that supermodernity kills mother and father. The Father-son relationship disappears at the very beginning of the

  15. Relationship Between the Menstrual Cycle and Timing of Ovulation Revealed by New Protocols: Analysis of Data from a Self-Tracking Health App.

    Science.gov (United States)

    Sohda, Satoshi; Suzuki, Kenta; Igari, Ichiro

    2017-11-27

    then demonstrated how the present calendar methods could be improved by the better grouping of women. This study suggested that even without integrating various biological metrics, the dataset collected by a self-tracking app can be used to develop formulas that predict the ovulation day when the data are aggregated. Because the method that we developed requires data only on the first day of menstruation, it would be the best option for couples during the early stages of their attempt to have a baby or for those who want to avoid the cost associated with other methods. Moreover, the result will be the baseline for more advanced methods that integrate other biological metrics. ©Satoshi Sohda, Kenta Suzuki, Ichiro Igari. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 27.11.2017.

  16. PREFACE: Workshop Photograph and Program

    Science.gov (United States)

    2011-07-01

    Workshop photograph Workshop Program Sunday 28 March 201019:00-21:00 Reception at Okura Frontier Hotel Tsukuba(Buffet style dinner with drink) Monday 29 March 2010Introduction (Chair: André Rubbia (ETH Zurich))09:00 Welcome address (05') Atsuto Suzuki (KEK)09:05 Message from CERN on neutrino physics (10') Sergio Bertolucci (CERN)09:15 Message from FNAL on neutrino physics (10') Young Kee Kim (FNAL)09:25 Message from KEK on neutrino physics (10') Koichiro Nishikawa (KEK)09:35 Introductory remark on GLA2010 (10') Takuya Hasegawa (KEK) Special session (Chair: Koichiro Nishikawa (KEK))09:45 The ICARUS Liquid Argon TPC (45') Carlo Rubbia (CERN)10:30-11:00 Coffee break Main goals of Giant Liquid Argon Charge Imaging Experiments I (Chair: Takashi Kobayashi (KEK))11:00 Results from massive underground detectors (non accelerator) (30') Takaaki Kajita (ICRR, U. of Tokyo)11:30 Present long baseline neutrino experiments (30') Chang Kee Jung (SUNY Stony Brook)12:00-12:10 Workshop picture12:10-14:00 Lunch break Main goals of Giant Liquid Argon Charge Imaging Experiments II (Chair: Takashi Kobayashi (KEK))14:00 Physics goals of the next generation massive underground experiments (30') David Wark (Imperial College London)14:30 Near detectors for long baseline neutrino experiments (20') Tsuyoshi Nakaya (Kyoto U.) Lessons on Liquid Argon Charge Imaging technology from ongoing developments (Chair: Chang Kee Jung (SUNY Stony Brook))14:50 WARP (30') Claudio Montanari (U. of Pavia)15:20 ArDM (30') Alberto Marchionni (ETH Zurich)15:50 From ArgoNeuT to MicroBooNE (30') Bonnie Fleming (Yale U.)16:20 250L (30') Takasumi Maruyama (KEK)16:50 The DEAP/CLEAN project (20') Mark Boulay (Queen's U.)17:10-17:40 Coffee break Lessons from Xe based Liquids Imaging detectors (Chair: Flavio Cavanna (U. of L'Aquilla))17:30 MEG (20') Satoshi Mihara (KEK)17:50 The XENON project (20') Elena Aprile (Columbia U.)18:10 XMASS (20') Hiroyuki Sekiya (ICRR, U. of Tokyo) Studies on physics performance (Chair

  17. Committees

    Science.gov (United States)

    2012-11-01

    Quebec IREQ, Varennes Canada Etienne PARKINSON Andritz Hydro Ltd. Switzerland B V S S S PRASAD Indian Institute of Technology Madras India Stefan RIEDELBAUCH Stuttgart University Germany Michel SABOURIN Alstom Hydro Canada Inc Canada Bruno SCHIAVELLO Flowserve Corporation USA Katsumasa SHIMMEI Hitachi Ltd Japan Christoph SINGRTüN VDMA Germany Ale? SKOTAK CKD Blansko Engineering, a s Czech Republic Toshiaki SUZUKI Toshiba Corporation Japan Andy C C TAN Queensland University of Technology Australia Geraldo TIAGO FILHO Universidade Federal de Itajuba Brazi Thi C VU Andritz Hydro Ltd Canada Satoshi WATANABE Kyushu University Japan S H WINOTO National University of Singapore Singapore Woo-Seong WOO STX Institute of Technology Korea International Technical Committee François AVELLAN (principal) EPFL-LMH Switzerland Xingqi LUO (principal) Xi'an University of Technology China Martin BÖHLE Kaiserslautern University Germany Gerard BOIS ENSAM France Young-Seok CHOI KITECH Korea Luca d'AGOSTINO University of Pisa Italy Eduard EGUSQUIZA Polytechnical University Catalonia Spain Arpad FAY University of Miskolcz Hungary Richard FISHER Voith Hydro Inc USA Regiane FORTES-PATELLA Institute Polytechnique de Grenoble France Aleksandar GAJIC University of Belgrade Serbia José GONZÁLEZ Universidad de Oviedo Spain François GUIBAULT Ecole Polytechnique de Montreal Canada Toshiaki IKOHAGI Tohoku University Japan Chisachi KATO University of Tokyo Japan Kwang-Yong KIM Inha University Korea Youn-Jea KIM Sungkyunkwan University Korea Smaine KOUIDRI Université Pierre et Marie Curie (Paris 6) France Shengcai LI Warwick University UK Adrian LUNGU Dunarea de Jos University of Galati Romania Torbjøm K NIELSEN NTNU Norway Michihiro NISHI Tsinghua University China Peter PELZ Darmstadt University Germany Frantisek POCHYLY Brno University Czech Republic Albert RUPRECHT University of Stuttgart Germany Rudolf SCHILLING Technische University München Germany Wei SHYY HKUST Hong Kong,China Romeo SUSAN

  18. EDITORIAL: Announcing the 2005 Measurement Science and Technology Outstanding Paper Awards

    Science.gov (United States)

    Foss, John; Dewhurst, Richard; Fujii, Kenichi; Regtien, Paul

    2006-06-01

    , whilst maintaining the linewidth of the seed laser source. Careful laboratory calibration tests are then described, showing benchmark results of sub-ppm sensitivity, and excellent system linearity up to 100 ppm. The final section describes the condition under which field tests were conducted, and validates the photoacoustic method by cross reference with both a Draeger sensor and an ion chromatograph. Overall, the paper possesses several innovative ideas. It is a well-structured paper, containing details of the instrumentation and techniques used. It has a careful discussion of the data and its validation, in order to realize the precision demonstrated. It is an innovative system required for a topical need within environmental protection. 2005 Award Winners—Precision Measurement The 2005 Measurement Science and Technology Outstanding Paper Award in the Precision Measurement category has been awarded to Ichiko Misumi, Satoshi Gonda, Qiangxian Huang, Taeho Keem, Tomizo Kurosawa (National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology (NMIJ/AIST), Japan), Akihiro Fujii, Nahoko Hisata, Takeshi Yamagishi, Hirohisa Fujimoto (Olympus Corporation, Japan), Ken Enjoji (Olympus Systems Corporation, Japan), Sunao Aya and Hiroaki Sumitani (Mitsubishi Electric Corporation, Japan) for the article 'Sub-hundred nanometre pitch measurements using an AFM with differential laser interferometers for designing usable lateral scales', published in volume 16, issue 10, pp 2080 2090. In making their recommendation the Precision Measurements working group chaired by Dr Kenichi Fujii gave the following endorsement: This paper describes a new instrument developed for measuring the pitches of one-dimensional grating standards. In the field of nanotechnology and in the semiconductor industry, reliable one-dimensional grating standards have been solicited for calibrating length measurement in nanometre regions. In the instrument described here, an

  19. The First 24 Years of Reverse Monte Carlo Modelling, Budapest, Hungary, 20-22 September 2012

    Science.gov (United States)

    Keen, David A.; Pusztai, László

    2013-11-01

    -ray scattering and modeling studiesL Hawelek, A Brodka, J C Dore, V Honkimaki and A Burian Local structure correlations in plastic cyclohexane—a reverse Monte Carlo studyNicholas P Funnell, Martin T Dove, Andrew L Goodwin, Simon Parsons and Matthew G Tucker Neutron powder diffraction and molecular dynamics study of superionic SrBr2S Hull, S T Norberg, S G Eriksson and C E Mohn Atomic order and cluster energetics of a 17 wt% Si-based glass versus the liquid phaseG S E Antipas, L Temleitner, K Karalis, L Pusztai and A Xenidis Total scattering analysis of cation coordination and vacancy pair distribution in Yb substituted Ō-Bi2O3G S E Antipas, L Temleitner, K Karalis, L Pusztai and A Xenidis Modification of the sampling algorithm for reverse Monte Carlo modeling with an insufficient data setSatoshi Sato and Kenji Maruyama The origin of diffuse scattering in crystalline carbon tetraiodideTemleitner and L Pusztai Silver environment and covalent network rearrangement in GeS3-Ag glassesL Rátkai, I Kaban, T Wágner, J Kolár, S Valková, Iva Voleská, B Beuneu and P Jóvári Reverse Monte Carlo study of spherical sample under non-periodic boundary conditions: the structure of Ru nanoparticles based on x-ray diffraction dataOrsolya Gereben and Valeri Petkov Total neutron scattering investigation of the structure of a cobalt gallium oxide spinel prepared by solvothermal oxidation of gallium metalHelen Y Playford, Alex C Hannon, Matthew G Tucker, Martin R Lees and Richard I Walton The structure of water in solutions containing di- and trivalent cations by empirical potential structure refinementDaniel T Bowron and Sofia Díaz Moreno The proton conducting electrolyte BaTi0.5In0.5O2.75: determination of the deuteron site and its local environmentStefan T Norberg, Seikh M H Rahman, Stephen Hull, Christopher S Knee and Sten G Eriksson Acidic properties of aqueous phosphoric acid solutions: a microscopic viewI Harsányi, L Pusztai, P Jóvári and B Beuneu Comparison of the atomic level

  20. EDITORIAL: Announcing the 2010 Measurement Science and Technology Outstanding Paper Awards Announcing the 2010 Measurement Science and Technology Outstanding Paper Awards

    Science.gov (United States)

    Foss, John; Dewhurst, Richard; Fujii, Kenichi; Regtien, Paul

    2011-06-01

    dc magnetic field for stable and supercooled liquid silicon Hidekazu Kobatake, Hiroyuki Fukuyama, Takao Tsukada and Satoshi Awaji Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2-1-1 Katahira, Aoba, Sendai, 980-8577, Japan Department of Chemical Engineering, Tohoku University, Aramaki Aoba, Aoba-ku, Sendai, 980-8577, Japan Institute for Materials Research (IMR), Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan An accurate value of the thermal conductivity of supercooled liquid silicon proves very helpful to better numerical heat flow models used for the production of high-quality silicon crystals. Measuring this important parameter is a challenge since the accuracy is frustrated by convections and imprecise non-contact temperature measurements, resulting in a wide variation of values reported in the literature so far. By improving the non-contact temperature measurement on a magnetically levitated drop of silicon the authors succeeded in a substantial reduction of the uncertainty in the measured values of the heat capacity and the thermal conductivity including their temperature dependence. Modulation of the heat power and an accurate measurement of the amplitude and phase of the resulting temperature variation constitute the major contribution to a higher accuracy. In their winning paper [4] the authors present a clear overview of their measurement setup and the experimental procedure and conditions, and give an extensive analysis of the parameters that play a part in the overall uncertainty. Measured values are compared with those obtained by other methods and reported in relevant literature. Moreover, the improvements of the instrumentation implemented by the authors contribute to a better understanding of the heat transport processes in liquid silicon. The four chairmen would like to thank the authors for choosing to publish their work in Measurement Science and Technology, and hope that other

  1. Radicals and Non-Equilibrium Processes in Low-Temperature Plasmas

    Science.gov (United States)

    Petrović, Zoran; Mason, Nigel; Hamaguchi, Satoshi; Radmilović-Radjenović, Marija

    2007-06-01

    almost exactly, may put us in position ask some fundamental questions while contributing to the benefit of mankind. We are grateful to all the members of the Gaseous Electronics Laboratory for organization of the event, in particular the members of the organizing committee and the staff of the Academy of Science and Institute of Physics. Finally and above all we acknowledge the great efforts of all the participants who have invested a lot of funds, their time and effort to join us, sometimes travelling from distant continents. The conference was primarily supported by ESF Program Electron Induced Processing at the Molecular Level. Additional funding and facilities were provided by the COE Optical and Electronic Device Technology for Access Network (Keio University), Ministry of Science of the Republic of Serbia; Academy of Sciences and Arts of Serbia, Institute of Physics Belgrade, COE Nonequilibrium processes in plasma physics and environmental science and Hiden Analytical. Zoran L J Petrović, Nigel Mason, Satoshi Hamaguchi and Marija Radmilović-Radjenović Editors

  2. Percepção dos produtores rurais de Tupã, SP, sobre o processo de comunicação para execução da logística reversa de embalagens de agrotóxicos

    Directory of Open Access Journals (Sweden)

    Cristiane Hengler Corrêa Bernardo

    2015-12-01

    agricultores gaúchos e mineiros. Revista de Economia e Sociologia Rural, v. 50, n. 1, p. 157-174, 2012. LEITE, Paulo Roberto. Logística Reversa - Nova área da logística empresarial. Revista Tecnologística, maio/2002. São Paulo, Edit. Publicare. MARCONI, M.A.; LAKATOS, E.M. Metodologia Científica. 6.ed.São Paulo: Atlas, 2011. MARCONI, Marina de Andrade; LAKATOS, Eva Maria. Técnicas de Pesquisa. 7 ed. São Paulo: Atlas, 2010. MAZZA, V.M.D.S. et al. Gestão de Resíduos Sólidos em Propriedades Rurais de Municípios do Interior do Estado do Rio Grande do Sul. Revista em Agronegócio e Meio Ambiente, Maringá, v. 7, n. 3, p. 683-706, Sep 2014. MELO, Wederson Miranda et al. Logística Reversa de Embalagens de Agrotóxicos: um estudo de caso na cidade de Patos-MG. VIII Congresso Nacional de Excelência em Gestão, 8 e 9 de junho de 2012. ISSN 1984-9354. MILLER, Chad R.; SARDER, M. D. Public works policy implications of sustainable reverse logistics operations. Public Works Management & Policy, p. 1087724X11429044, 2011. MOTTA, Wladmir Henriques. Análise do Ciclo de Vida e Logística Reversa. X SEGeT 2013 Simpósio de Excelência em Gestão e Tecnologia. Gestão e Tecnologia para a Competitividade. 23,24,25 out/2013. MOURÃO, Renata Fernandes; SEO, Emília Satoshi Miyamaru. Logística reversa de lâmpadas fluorescentes. InterfacEHS Revista de Saúde, Meio Ambiente e Sustentabilidade. V. 7, N. 3, 2012. OLIVEIRA, Andréa Leda Ramos de; CAMARGO, Samira Gaiad Cibim de. Logística Reversa de Embalagens de Agrotóxicoss: identificação dos determinantes de sucesso. Interciencia, Caracas, v. 39, n. 11, p. 780-787, 11 2014. PESTANA, M. H.; GAGEIRO, J. N. Análise de dados para ciências sociais: a complementaridade do SPSS. 2003. SILVA, D.; LOPES, Evandro Luiz; BRAGA JUNIOR, S. S. Pesquisa Quantitativa: Elementos, Paradigmas e Definições. Revista de Gestão e Secretariado, v. 5, n. 1, p. 01-18, 2014. VEZZALI, F. Opiniao-A soja eleva risco de contaminacao de trabalhadores por