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Sample records for cor pulmonale due

  1. Cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930475 The study of prethrombotic state in pa-tients with COPD and cor pulmonale.MA Duan(马端),et al.Thrombosis & HaemostasisLab,Shandong Traffic Hosp,Jinan,250031.ChinJ Tuberc & Respir Dis 1993;16(2):95—97.We measured PT,TT,KPTT,Fg,vWF,AT—IILAg,AT—ⅢA,a2M,TXB2,6—keto—PGFla,PLg,tPAAg,tPAA and PAl of patients with a-cute onset of chronic bronchitis,pulmonary em-physema,and cor pulmonale.The results stated

  2. Cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    950272 A clinicopathological study of cor pulmonalewith coronary heart disease.TANG Peihua(汤佩华),et al.Beijing Red Cross Chaoyang Hosp.Beijing,100020.Chin J Intern Med 1995;34(3):185-189.The necropsy findings of 18 patients with cot pui-monale and coronary heart disease(CHD) were com-pared with those of a control group of 30 patients withcor pulmonale alone.The results showed that therewas no significant statistical difference between the

  3. Cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    970286 Efficacy of prostaglandin EI in treatment ofcor pulmonale patients with heart failure. ZHOUShuneheng(周顺成), et al. Dept Respir Dis, 2ndPeople’S Hosp, Hubei, 434000. Chin J Tuberc RespirDis 1997; 20(2): 88-90. objective: To investigate the effects of prostaglandin

  4. Pulmonary tumor thrombotic microangiopathy with cor pulmonale due to desmoplastic small round cell tumor.

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    Sadimin, Evita T; Collier, Adrienne G; Gaffney, Joseph W; Fyfe, Billie

    2012-04-01

    A 12-year-old boy presented acutely after an episode of syncope with perioral cyanosis. He died 19 hours after admission due to cor pulmonale as a complication of metastatic desmoplastic small round cell tumor in the lungs with associated tumor thrombotic microangiopathy.

  5. Acute cor pulmonale.

    Science.gov (United States)

    Jardin, François; Vieillard-Baron, Antoine

    2009-02-01

    Acute cor pulmonale is a form of acute right heart failure produced by a sudden increase in resistance to blood flow in the pulmonary circulation, which is now rapidly recognized by bedside echocardiography. In the clinical setting, acute cor pulmonale is mainly observed as a complication of massive pulmonary embolism or acute respiratory distress syndrome. In acute respiratory distress syndrome, the worsening effect of mechanical ventilation has been recently emphasized. As a general rule, the treatment consists in rapidly reducing resistance to blood flow in the pulmonary circulation, obtained by a specific strategy according to etiology.

  6. An autopsy case of subacute cor pulmonale due to pulmonary tumor cell emboli in a patient with gastric cancer.

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    Iwakami, Shin-ichiro; Sato, Teruhiko; Takagi, Haruhi; Fujii, Mitsuhiro; Iwakami, Naoko; Yoshimi, Kaku; Koyama, Ryo; Ichikawa, Masako; Yoshioka, Masakata; Takahashi, Kazuhisa

    2009-01-01

    A 53-year-old woman was admitted to our hospital due to a severe respiratory condition and malnutrition. Radiological and electrophysiological findings suggested the existence of inexplicable cor pulmonale. Although we commenced to determine the causes of her severe condition, she suddenly died 3 days after admission. Postmortem autopsy revealed tumor cell microemboli in the small pulmonary arteries due to gastric cancer. Such a case of cor pulmonale as the first clinical manifestation is exceptionally rare. Occult malignancy should be considered as a differential diagnosis when one encounters a patient with subacutely aggravated respiratory condition and inexplicable cor pulmonale.

  7. Acute cor pulmonale due to lymphocytic interstitial pneumonia in a child with AIDS

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    Sandra Fagundes Moreira-Silva

    Full Text Available BACKGROUND: Acute cor pulmonale is a clinical syndrome with signs of right-sided heart failure resulting from sudden increase of pulmonary vascular resistance. CASE PRESENTATION: A five-year-old male, infected by human immunodeficiency virus (HIV, was admitted at the division of infectious diseases of this hospital with cough, tachydyspnea, fever, and breathing difficulty. Computed tomography scan showed ground-glass opacities, cystic lesions, and bronchiectasis. The patient had nasal flaring, intercostal and subcostal retractions, and keeled chest. Abdomen was depressible; liver was 3 cm from the right-costal border, while spleen was 6 cm from the left-costal border. Echocardiogram examinations showed signs of acute cor pulmonale characterized by pulmonary hypertension and increased right-heart chamber dimensions. DIAGNOSTICS OUTCOME: Acquired immunodeficiency syndrome (AIDS-B3, lymphocytic interstitial pneumonia (LIP, and acute cor pulmonale. Regressions of pulmonary hypertension and of right-heart chamber were observed after 30 days of highly active antiretroviral therapy (HAART and chloroquine therapy. CONCLUSION: AIDS should be considered in children with recurrent pneumonia that is mostly associated with LIP rather than cystic fibrosis.

  8. 10.4.Cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930265 Effect of ligustrazine controlled re-lease capsule on hemorrheoiogy in patients withcor pulmonale.PENG Wei (彭伟),DUANShengfu (段生福).Respir Dis Res Instit,Tongji Hosp,Tongji Med Univ,Wuhan,430030.Chin J Intern Med 1993;32(1):37-39.Before and after oral administration of Ligus-trazine controlled release capsule,changes ofhemorrheology and TXA2/PGI2 were evaluatedin 16 patients with advanced cor pulmonale.Itwas shown that the effects of decreasing wholeblood and plasma viscosity and lowering hemat-ocrit and fibrinogen level were noted after onecourse of treatment with this medication.Itsuggests that anticoagulanting effect of Ligus-

  9. [Right heart failure and cor pulmonale].

    Science.gov (United States)

    Leschke, M; Wädlich, A

    2007-09-01

    Whereas the right ventricle tolerates volume loads without any substantial increase of the pressure in the pulmonary circulation by recruiting capacitance vessels and capillaries, it possesses only small contractile reserves and reacts unadapted with right ventricular dysfunction. Its size and pressure load are relevant factors for prognosis of all forms of pulmonary hypertension, in particular if linked to left-sided heart failure. Differentiation of pulmonary hypertension according to the Venice classification is highly important. Right-sided ventricular heart failure worsens left ventricular hemodynamics due to reduced ejection fraction and in addition due to direct diastolic ventricular interaction in which left ventricular diastolic dysfunction increases even though the left ventricular systolic function is still intact. Right ventricular ejection fraction cor pulmonale. While long-term oxygen therapy in patients with COPD and cor pulmonale and for example the administration of endothelin receptor antagonists in patients with idiopathic pulmonary hypertension is beneficial, the therapeutic use of drugs effective for left-sided heart failure is very limited in patients with right ventricular dysfunction.

  10. Clinical course of cor pulmonale investigated after an interval of one year by thallium-201 myocardial SPECT scintigraphy

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    Yamaoka, Shimpachi; Nishimura, Kouichi; Kuno, Kenshi; Yonekura, Yoshiharu; Koide, Harutoshi.

    1988-06-01

    Cor pulmonale was evaluated in 13 patients with chronic lung disease by thallium-201 myocardial SPECT scintigraphy together with pulmonary function tests and right heart catheterization. One year later, we performed this scintigraphy again to investigate the clinical course of the cor pulmonale. In 6 of 13 patients with respiratory failure (Pao/sub 2/ less than 60 Torr), a remarkable progression in cor pulmonale was noted after one year, despite outpatient oxygen therapy. If the patients were admitted because of acute exacerbation of respiratory failure, the cor pulmonale was found to have worsened. In contrast, patients with acute exacerbation due to respiratory infection or causes other than respiratory failure, showed little change in cor pulmonale. Although patients with a marked progression of cor pulmonale tended to have poor pulmonary function data and elevated pulmonary arterial pressure, the clinical course of cor pulmonale could not be predicted from the initial pulmonary function tests or right heart catheterization.

  11. Cor pulmonale in a case of infantile Gaucher's disease.

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    Patra, Soumya; Chatterjee, Sayan; Singhla, Shilpi; Patra, Bijoy; Maheswari, Anu; Seth, Anju

    2011-04-01

    Infantile Gaucher's disease presenting as cor pulmonale is rarely reported in pediatric literature. We report a 3.3 year old boy with infantile Gaucher's disease who presented to us as interstitial lung disease, pulmonary hypertension along with features of cor pulmonale. The high resolution CT findings were typical of interstitial and airspace disease. Cor pulmonale in this patient was a result of severe pulmonary hypertension.

  12. Pulmonary hypertension and chronic cor pulmonale in COPD.

    Science.gov (United States)

    Shujaat, Adil; Minkin, Ruth; Eden, Edward

    2007-01-01

    Hypoxia and endothelial dysfunction play a central role in the development of pulmonary hypertension. Cor pulmonale is a maladaptive response to pulmonary hypertension. The presence of peripheral edema in cor pulmonale is almost invariably associated with hypercapnia. Correction of abnormalities of gas exchange and ventilation can ameliorate pulmonary hypertension and improve survival. This review focuses on new information about the pathogenesis and treatment of pulmonary hypertension in COPD including information derived from lung volume reduction surgery, the role of brain natriuretic peptide, exhaled nitric oxide for diagnosis, and the treatment of cor pulmonale with recently available specific pulmonary vasodilators.

  13. An autopsy case of acute cor pulmonale and paradoxical systemic embolism due to tumour cell microemboli in a patient with breast cancer.

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    Uga, Sayuri; Ikeda, Shuntaro; Matsukage, Sho-ichi; Hamada, Mareomi

    2012-09-30

    A 62-year-old woman was admitted to our hospital because of severe respiratory distress. Diagnostic imaging studies suggested the existence of inexplicable cor pulmonale. Although we immediately sought the aetiology of her severe condition, she died suddenly on the fourth day after admission. Postmortem autopsy revealed tumour cell microemboli in the small pulmonary arteries. In addition, tumour cell embolisation identical to that in primary breast cancer cells was also observed in microvessels in systemic multiple organs, such as the liver, brain, kidneys, spleen, uterus, bone marrow and adrenal glands-with simultaneous findings of peripheral infarction. Systemic tumour cell embolism mediated through the patent foramen ovale superimposed on pulmonary tumour cell emboli (PTCE) is considered to be the mechanism underlying inexplicable cor pulmonale. The rapid aggravation of her condition terminated in death.

  14. INSUFICIENCIA CARDÍACA CONGESTIVA O COR PULMONALE Congestive heart failure or Cor Pulmonale

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    Oscar Ernesto Amarís Peña

    2006-06-01

    Full Text Available La insuficiencia cardíaca es una de las principales causas de muerte cardiovascular y se presenta como consecuencia, en más del 70 por ciento de los casos, de las dos enfermedades cardiovasculares de mayor prevalencia: la hipertensión arterial y la enfermedad coronaria. La disnea y el edema en los miembros inferiores son los dos criterios más usados para el diagnóstico de insuficiencia cardíaca congestiva y estos son, justamente, las principales manifestaciones de los pacientes con Cor Pulmonale. Este documento propone algunos criterios para el diagnóstico diferencial de las dos entidades.Heart failure is one of the most important causes of cardiovascular death, as consequence of arterial hypertension or coronary heart disease. Dyspnea and legs edema are the commonest symptoms of congestive heart failure, but there are important symptoms in Cor Pulmonale, too. This paper propose some distinctive clues to differential diagnosis.

  15. Efficacy of inhaled iloprost in cor pulmonale and severe pulmonary hypertension associated with tuberculous destroyed lung.

    Science.gov (United States)

    Park, Yae Min; Chung, Wook-Jin; Lee, Sang Pyo; Choi, Deok Young; Baek, Han Joo; Jung, Sung Hwan; Choi, In Suck; Shin, Eak Kyun

    2014-06-01

    Chronic obstructive pulmonary disease (COPD) is one of the causes of cor pulmonale. Cor pulmonale patients with pulmonary hypertension have a significant lower survival rate than patients without. However, there is no conclusive treatment options in cor pulmonale and pulmonary hypertension associated with COPD until now. We report a patient with cor pulmonale and pulmonary hypertension associated with severe form of COPD and tuberculous destroyed lung who achieved marked clinical, functional and echocardiographic hemodynamic improvements with inhaled iloprost for six months.

  16. Nesiritide for pulmonary arterial hypertension with decompensated cor pulmonale.

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    Kingman, Martha S; Thompson, Brenda S; Newkirk, Trixie; Torres, Fernando

    2005-01-01

    Pulmonary arterial hypertension complicated by decompensated cor pulmonale is a challenging clinical problem with few effective therapeutic options. B-type natriuretic peptide is a pluripotent hormone that promotes diuresis and natriuresis, vasodilates systemic and pulmonary vessels, and reduces circulating levels of endothelin and aldosterone. It may represent a possible therapeutic strategy for decompensated cor pulmonale in the same manner that it is used to treat decompensated left heart failure. The authors report their experience with B-type natriuretic peptide as adjunctive therapy for pulmonary arterial hypertension complicated by decompensated cor pulmonale. A detailed case report is presented followed by the evaluation of a series of 11 cases occurring in eight patients from December 2002 through April 2004.

  17. Paroxysmal atrial fibrillation and clinically reversible cor pulmonale in a horse with complicated recurrent airway obstruction.

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    Hanka, J; van den Hoven, R; Schwarz, B

    2015-01-01

    Cor pulmonale is considered an uncommon complication in horses with recurrent airway obstruction (RAO). This case report describes the history, clinical and further examination findings, treatment, progression and outcome of a horse diagnosed with cor pulmonale and paroxysmal atrial fibrillation of 2 days duration due to a severe exacerbation of RAO. To our best knowledge, this is the first report of RAO induced pulmonary hypertension in a horse causing atrial fibrillation. However, even severe cardiac changes due to respiratory dysfunction seem to be largely reversible in horses.

  18. Rheumatoid interstitial lung disease presenting as cor pulmonale

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    Acharya Sourya

    2010-01-01

    Full Text Available Rheumatiod arthritis (RA is a multisystem connective tissue disorder. The predominant presentation is polyarticular, symmetric peripheral arthritis with relative sparing of axial skeleton. Inflammatory synovitis is the pathologic hallmark. Extra-articular manifestations of RA can involve several other organ systems and amongst them pulmonary manifestations occur commonly. We report a case of rheumatoid interstitial lung disease presenting as cor pulmonale.

  19. Rheumatoid interstitial lung disease presenting as cor pulmonale.

    Science.gov (United States)

    Acharya, Sourya; Mahajan, S N; Shukla, Samarth; Diwan, S K; Banode, Pankaj; Kothari, Nirmesh

    2010-10-01

    Rheumatiod arthritis (RA) is a multisystem connective tissue disorder. The predominant presentation is polyarticular, symmetric peripheral arthritis with relative sparing of axial skeleton. Inflammatory synovitis is the pathologic hallmark. Extra-articular manifestations of RA can involve several other organ systems and amongst them pulmonary manifestations occur commonly. We report a case of rheumatoid interstitial lung disease presenting as cor pulmonale.

  20. [Diagnosis of predisposition to chronic cor pulmonale formation in occupational lung diseases caused by dust].

    Science.gov (United States)

    Panev, N I; Korotenko, O Iu; Zakharenkov, V V; Korchagina, Iu S; Gafarov, N I

    2014-01-01

    Study covered 426 miners aged 40-54 years with previously diagnosed occupational respiratory diseases due to dust (246 patients with chronic occupational obstructive bronchitis, 98 with anthracosilicosis and 82 with chronic dust nonobstructive bronchitis). 315 (73.9%) examinees out of 426 with lung diseases due to dust demonstrated chronic cor pulnmonale. Considering high share of this complication, the authors used Bayes method to create a method to diagnose predisposition towards chronic cor pulmonale in patients with dust lung diseases through respiratory failure, concomitant coronary heart disease and arterial hypertension, blood groups ABO, MN and P, some structural and functional parameters of heart: myocardium weight index, relative wall thickness index and left ventricle sphericity index, average lung artery pressure. Increasing number of analyzed factors that directly influence chronic cor pulmonale development and selecting additional markers help to improve forecasting of the complication.

  1. Cor pulmonale in a case of infantile Gaucher′s disease

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    Soumya Patra

    2011-01-01

    Full Text Available Infantile Gaucher′s disease presenting as cor pulmonale is rarely reported in pediatric literature. We report a 3.3 year old boy with infantile Gaucher′s disease who presented to us as interstitial lung disease, pulmonary hypertension along with features of cor pulmonale. The high resolution CT findings were typical of interstitial and airspace disease. Cor pulmonale in this patient was a result of severe pulmonary hypertension.

  2. The Specific Characteristics in Children with Obstructive Sleep Apnea and Cor Pulmonale

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    Pi-Chang Lee

    2012-01-01

    Full Text Available Background. The prevalence of obstructive sleep apnea (OSA in the pediatric population is currently estimated at 1-2% of all children. The purpose of this study was to investigate the clinical and hemodynamic characteristics in pediatric patients with cor pulmonale and OSA. Methods. Thirty children with the diagnosis of OSA were included. These patients consisted of 26 male and 4 female children with a mean age of 7 ± 4 years old. Five of those children were found to be associated with cor pulmonale, and 25 had OSA but without cor pulmonale. Results. The arousal index was much higher in children with OSA and cor pulmonale. The children with OSA and cor pulmonale had much lower mean and minimal oxygen saturation and a higher incidence of bradycardia events. All 5 patients with OSA and cor pulmonale underwent an adenotonsillectomy, and the pulmonary arterial pressure dropped significantly after the surgery. Conclusion. This study demonstrated that the OSA pediatric patients with cor pulmonale had the different clinical manifestations and hemodynamic characteristics from those without cor pulmonale. The adenotonsillectomy had excellent results in both the OSA pediatric patients with and without cor pulmonale.

  3. Insuficiencia cardíaca congestiva o cor pulmonale

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    Amarís Peña, Óscar Ernesto

    2014-01-01

    La insuficiencia cardíaca es una de las principalescausas de muerte cardiovascular y se presentacomo consecuencia, en más del 70 porciento de los casos, de las dos enfermedadescardiovasculares de mayor prevalencia: lahipertensión arterial y la enfermedad coronaria.La disnea y el edema en los miembros inferioresson los dos criterios más usados para el diagnósticode insuficiencia cardíaca congestiva yestos son, justamente, las principales manifestacionesde los pacientes con Cor Pulmonale.Este d...

  4. Echocardiographic findings in a goat with cor pulmonale secondary to chronic parasitic pneumonia.

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    Buczinski, S; Pinard, J; Ferrouillet, C; Veillette, M

    2010-02-01

    A four-year old goat was presented for anorexia and apathy since kidding one week earlier. Physical examination revealed dyspnea, extensive ascites and bilateral distended jugular veins, suggestive of congestive right heart failure. The echocardiographic findings of severe right ventricular and atrial dilatation were consistent with right heart failure. In the absence of abnormalities in the right ventricular outflow tract a diagnosis of cor pulmonale secondary to lung disease was posed. Due to a poor prognosis, the goat was euthanized. Necropsy confirmed cor pulmonale and identified severe chronic parasitic pneumonia as underlying cause. Echocardiography is an interesting tool also applicable in the farm for diagnosing heart diseases in goats, and its use should help to avoid unnecessary therapy in cases with a poor prognosis.

  5. A case report of cor pulmonale in a woman without exposure to tobacco smoke: an example of the risks of indoor wood burning.

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    Opotowsky, Alexander R; Vedanthan, Rajesh; Mamlin, Joseph J

    2008-01-29

    We present the case of a 67-year-old woman with chronic cor pulmonale. She never smoked tobacco and had no other risk factors for pulmonary disease. In developed nations, chronic obstructive lung disease and cor pulmonale are overwhelmingly associated with tobacco use. However, indoor air pollution, most commonly due to burning of solid biomass fuel such as wood, can cause similar clinical syndromes. At our teaching hospital, there is an epidemic of chronic cor pulmonale among nonsmoking women. We attribute this sex predilection to women's greater exposure to wood smoke. Physicians must be cognizant of its risks and counsel patients on prevention strategies such as improved ventilation.

  6. Modulation of monocrotaline-induced cor pulmonale by grape juice.

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    Ludke, Ana R L; Mosele, Francisca; Caron-Lienert, Rafaela; Ribeiro, Maria Flávia; Partata, Wânia; Llesuy, Susana; Araujo, Alex Sander; Singal, Pawan; Belló-Klein, Adriane

    2010-01-01

    The study was designed to test whether the ingestion grape juice (GJ) could modulate monocrotaline (MCT)-induced Cor pulmonale resulting from antioxidant properties. Three-week-old male Wistar rats received GJ (10 mL/kg/day) by gavage for 6 weeks. A single injection of MCT (60 mg/kg body weight intraperitoneally) was administered at the end of the third week. Animals were divided in four groups: control, MCT, GJ, and GJ + MCT. MCT promoted a significant increase in right ventricle (36%) and lung (70%) weight to body weight ratio. There was an increase in the right systolic (38%) as well as in the end diastolic (70%) ventricular pressures. MCT caused a significant decrease in lung endothelial nitric oxide synthase (20%) but increase in lipid peroxidation (13%) and catalase (43%). MCT-induced decrease in the endothelial nitric oxide synthase and increase in the right ventricular end diastolic pressure were prevented by GJ, whereas right systolic ventricular pressure and lung weight to body weight ratio were corrected only partially. MCT-induced increase in heart and right ventricle to body weight ratios was not changed by GJ. GJ blunted MCT-induced increase in lipid peroxidation but had no effect on the changes in catalase and superoxide dismutase activities. GJ appears to offer some protection against MCT-induced Cor pulmonale and right ventricle function changes.

  7. An interesting case of cor pulmonale

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    Bagrecha Manish V, Kunkulol Rahul R

    2013-01-01

    Full Text Available A 14 yrs old boy presented with a history of breathlessness since 1 yr which had increased from 2 days, cough with expectoration and pedal edema since 7 days. In the past patient had history of kyphoscoliosissince birth and had a history of repeated URTI. On examination he had tachycardia, tachypnea, raised JVP, kyphoscoliosis, bilateral pitting edema. Respiratory auscultation revealed bilateral fine crepitations and wheezes. On investigation haemoglobin: 14.6, T.L.C: 20,000,chest X-ray: kyphoscoliosis with cardiomegaly. Clinical diagnosis of corpulmonale due to kyphoscoliosis was achieved and was confirmed with 2D echo. ECG showed RVH. The patient was treated with oxygen, diuretics, antibiotics, bronchodilators. Patient improved and was discharged on bronchodilators and was asymptomatic on follow up.

  8. A case of pulmonary alveolar microlithiasis with Cor Pulmonale.

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    Chen, Wen; Gu, Tao

    2012-03-01

    Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by the formation and deposition of microliths within the alveoli and a paucity of symptoms in contrast to the imaging findings. It has familial tendency and is thought to be an autosomal recessive disorder with the mutation in the SLC34A2 gene. We describe a case of PAM with Cor Pulmonale. Ultrasonic cardiogram showed pulmonary hypertension (82 mmHg). Chest radiography revealed diffuse, bilateral sandstorm-like micronodules with greater density in the lower lung fields. HRCT scans demonstrated diffuse ground-grass opacities, thickening and calcification of interlobular septa and confluent calcified nodules. A diagnosis of PAM was suggested and confirmed by transbronchial lung biopsy (TBLB).

  9. Clinical and morphologic features of acute, subacute and chronic cor pulmonale (pulmonary heart disease).

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    Roberts, William Clifford; Shafii, Alexis E; Grayburn, Paul A; Ko, Jong Mi; Weissenborn, Matthew R; Rosenblatt, Randall L; Guileyardo, Joseph M

    2015-03-01

    Described are certain clinical and morphologic features of one patient with acute, another with subacute, and one with chronic cor pulmonale. All 3 had evidence of severe pulmonary hypertension. The patient with acute cor pulmonale 4 days after coronary bypass for unstable angina pectoris suddenly developed severe breathlessness with cyanosis and had fatal cardiac arrest and necropsy disclosed massive pulmonary embolism. The patient with subacute cor pulmonale had severe right-sided heart failure for 5 weeks and necropsy disclosed microscopic-sized neoplastic pulmonary emboli from a gastric carcinoma without parenchymal pulmonary metastases. The patient with chronic cor pulmonale had evidence of right-sided heart failure for years, the result of primary or idiopathic pulmonary hypertension almost certainly present from birth because the pattern of elastic fibers in the pulmonary trunk was that seen in newborns where the pressure in the pulmonary trunk and ascending aorta are similar. The patient with chronic cor pulmonale had plexiform pulmonary lesions indicative of irreversible pulmonary hypertension. Neither the acute nor the subacute patient had chronic pulmonary vascular changes. All 3 patients had dilated right ventricular cavities and non-dilated left ventricular cavities and only the patient with chronic cor pulmonale had right ventricular hypertrophy.

  10. Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats.

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    Abe, Chikara; Tsuru, Yoshiharu; Iwata, Chihiro; Ogihara, Ryosuke; Morita, Hironobu

    2013-01-01

    Intravenous hyperosmotic NaCl infusion is an effective treatment for circulatory shock. However, a fast infusion rate (2 mL/kg at the rate of 1 mL/s) induces transient hypotension. This response has been reported to be due to decreased total peripheral resistance and/or decreased cardiac performance. Although the hypotension is transient and recovers within 2 min without detrimental consequences, it is important to understand the associated hemodynamics and mechanisms. We found that the hypotensive effect was larger with intravenous NaCl infusion than with intra-aortic infusion, indicating that change in cardiac performance played a more significant role than change in peripheral resistance. NaCl infusion induced an increase in pulmonary vascular resistance and central venous pressure and a decrease in right ventricular dP/dt max, suggesting acute cor pulmonale. Diastolic ventricular crosstalk-induced left ventricular failure was also observed. Hyperosmotic NaCl-induced hypotension was therefore mainly due to a combination of acute cor pulmonale and left ventricular failure.

  11. [Characteristics of the electrocardiographic diagnosis in chronic cor pulmonale in the aged].

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    Korkusko, O V; Voznjuk, V V; Placinda JuI

    1984-01-01

    Detailed ECG analyses were made in 97 patients aged between 60 and 79 as well as in 64 younger patients (aged between 30 and 49) suffering from chronical cor pulmonale. Since typical ECG symptoms pointing to cor pulmonale occur less frequently in old age, an analysis scheme to facilitate diagnostics is suggested. The ECG criteria established by Widimsky to diagnose cor pulmonale are supposed to be hypothetical and, in particular, are not adequate for early stages of the clinical picture. Therefore, reference is made to the method by Dusanin , which postulates symptoms of dextrocardia and pulmonary hypertension as established assessment criteria. We recommend the consideration of seven ECG characteristics as a result of a thorough ECG analysis. These characteristics have been integrated in a diagnostical formula through mathematical processes.

  12. Higher Plasma Myostatin Levels in Cor Pulmonale Secondary to Chronic Obstructive Pulmonary Disease.

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    Chun-Rong Ju

    Full Text Available To analyze plasma myostatin levels and investigate their relationship with right ventricular (RV function in patients with cor pulmonale secondary to chronic obstructive pulmonary disease (COPD.The study recruited 81 patients with advanced COPD and 40 age-matched controls. The patients were divided into two groups: those with cor pulmonale and those without. Echocardiography was used to evaluate RV function and morphology, and the value of tricuspid annular plane systolic excursion (TAPSE less than 16 mm was considered RV dysfunction. Plasma myostatin levels were analyzed by enzyme-linked immunosorbent assay, and B-type natriuretic peptide (BNP levels were analyzed as a comparison of myostatin.The data detected cor pulmonale in 39/81 patients, with the mean value of TAPSE of 14.3 mm. Plasma myostatin levels (ng/mL were significantly higher in patients with cor pulmonale (16.68 ± 2.95 than in those without (13.56 ± 3.09, and much higher than in controls (8.79±2.79, with each p<0.01. Significant differences were also found in plasma BNP levels among the three groups (p<0.05. Multivariate regression analysis suggested that myostatin levels were significantly correlated with the values of TAPSE and RV myocardium performance index among the COPD patients, and that BNP levels were significantly correlated only with systolic pulmonary arterial pressure, with each p<0.05.Plasma myostatin levels are increased in COPD patients who have cor pulmonale. Stronger correlations of plasma myostatin levels with echocardiographic indexes of the right heart suggest that myostatin might be superior to BNP in the early diagnosis of cor pulmonale in COPD.

  13. Primair sarcoom van de A. pulmonalis : zeldzame oorzaak van cor pulmonale

    NARCIS (Netherlands)

    Ismaël, F; van der Werf, T S; de Boer, W J; Timens, W; Nossent, G D; Ligtenberg, J J

    1999-01-01

    A 64-year-old female presented with fever and weight loss, accompanied by normochromic normocytic anaemia with high erythrocyte sedimentation rate. She developed severe cor pulmonale. Ventilation-perfusion scintigraphy revealed a non-matched perfusion defect of the entire right lung with impaired pe

  14. Staphylococcal toxic shock syndrome presenting as acute respiratory distress and cor pulmonale.

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    Zaki, S A; Shanbag, P; Chavan, V; Shenoy, P

    2010-01-01

    We describe a 7-year-old boy with staphylococcal toxic shock syndrome who presented with acute respiratory distress and cor pulmonale. We wish to highlight this unusual presentation as the diagnosis of toxic shock syndrome depends chiefly on a high degree of clinical suspicion. Early diagnosis and prompt institution of appropriate therapy will significantly reduce morbidity and mortality.

  15. A rare case of cor pulmonale secondary to idiopathic pulmonary fibrosis in Nigeria.

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    Anakwue, Raphael Chinedu; Chijioke, Chioli Paschal; Iloanusi, Nneka Ifeyinwa

    2011-06-29

    Idiopathic pulmonary fibrosis (IPF) is a rarely reported disease in Nigeria. Cor pulmonale, one of the complications of this type of diffuse parenchymal lung disease is even rarer. The authors present a Nigerian patient with IPF with a classical high-resolution CT features, managed in our centre together with associated problems.

  16. Advanced sickle cell associated interstitial lung disease presenting with cor pulmonale in a Nigerian.

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    Fawibe, Ademola Emmanuel; Kolo, Philip Manman; Ogunmodede, James Ayodele; Desalu, Olufemi Olumuyiwa; Salami, Kazeem Alakija

    2012-04-01

    Previous studies have reported abnormal pulmonary function and pulmonary hypertension among Nigerians with sickle cell disease, but there is no report of interstitial lung disease among them. We report a Nigerian sickle cell patient who presented with computed tomography proven interstitial lung disease complicated by pulmonary hypertension and cor pulmonale.

  17. Restrictive lung disease and cor pulmonale secondary to polyostotic fibrous dysplasia.

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    Narayan, Rajeev L; Maldjian, Pierre D

    2009-01-09

    Polyostotic fibrous dysplasia is a rare benign pathological condition of bone in which proliferation of fibrous and osteoid elements results in expansile deformities of the skeleton. We present a case of polyostotic fibrous dysplasia in a young man in whom the severe deformities of the chest wall and spine produced restrictive lung disease, cor pulmonale and respiratory failure.

  18. Advanced sickle cell associated interstitial lung disease presenting with cor pulmonale in a Nigerian

    Directory of Open Access Journals (Sweden)

    Ademola Emmanuel Fawibe

    2012-01-01

    Full Text Available Previous studies have reported abnormal pulmonary function and pulmonary hypertension among Nigerians with sickle cell disease, but there is no report of interstitial lung disease among them. We report a Nigerian sickle cell patient who presented with computed tomography proven interstitial lung disease complicated by pulmonary hypertension and cor pulmonale.

  19. A STUDY OF CLINICAL PROFILE, RADIOLOGICAL FEATURES, ELECTROCARDIOGRAPHIC AND ECHOCARDIOGRAPHIC CHANGES IN CHRONIC COR PULMONALE IN A RURAL HOSPITAL

    Directory of Open Access Journals (Sweden)

    Sunil Babu

    2013-11-01

    Full Text Available ABSTRACT: BACKGROUND AND OBJECTIVES: To study the clinical profile, radiological features, electrocardiographic and echocardiographic changes in clinically proven cases of chronic cor pulmonale. METHODS: 50 patients who were diagnosed to have chronic cor pulmonale based on the inclusion criteria were selected from the medical wards of Adichunchanagiri Hospital and research centre, over a period of 2 years In all the selected patients detailed history and physical examination was noted and chest x - ray PA, 1 2 lead ECG and echocardiogram done. RESULTS: Among 50 patients admitted with chronic cor pulmonale, 45 were males and 5 were females. The peak incidence was found in the 4 th , 5 th and 6 th decades of life. Smoking was found to be a major cause for COPD and h ence cor pulmonale. Among 50 patients 43 were smokers. Among 50 cases, (60% were diagnosed to have chronic bronchitis with or without emphysema. Chest x - ray showed details relevant to the clinical profile. ECG showed 46% cases with RVH, 64% with RAD, 26% RBBB and 70% with P pulmonale. Every patient showed echocardiographic features suggesting chronic cor pulmonale except 3 patients who showed global hypokinesia. DISCUSSION AND CONCLUSION: Many patients who had chronic cor pulmonale were found to have COPD as the underlying disease. Majority of the male patients were smokers in the present study. Echocardiogram was found to be a better diagnostic tool. Though ECG and chest x - ray can support the diagnosis, ECHO can be used as a non invasive, affordable invest igation for accurate and early diagnosis of chronic cor pulmonale KEYWORDS: Chronic cor pulmonale; Clinical profile; Chest x ray; ECG; Echocardiogram.

  20. An unusual cause of acute cor pulmonale--significance of the 'continuous diaphragm sign'.

    Science.gov (United States)

    Mohanan, Sandeep; Sajeev, C G; Muneer, Kader; Rajesh, G; Krishnan, M N; Pillai, Vivek

    2014-01-01

    A patient presented with chest pain and clinical features of acute right heart failure. Initial work up revealed the presence of severe PAH. Acute pulmonary embolism is the commonest and most life-threatening cause for acute cor pulmonale. Even though the clinical picture suggested pulmonary embolism, a subtle sign was missed from the first chest X-ray taken in the emergency department. However on reanalysis the 'continuous diaphragm sign' later guided us towards the diagnosis. Our case represents one of the first reports of a rare etiology for acute cor pulmonale--hypersensitivity pneumonitis. Right ventricular dysfunction was caused by an acute rise in pulmonary artery pressures as well as by the compressive effects of pneumomediastinum. We emphasize the role played by a good quality chest X-ray early in the management of acute chest pain syndromes. However pulmonary embolism should be ruled out conclusively before redirecting attention to less malignant conditions.

  1. Nesiritide for the treatment of pulmonary hypertension and cor pulmonale in an infant.

    Science.gov (United States)

    Reynolds, E W; Conely, E T; Vranicar, M

    2007-01-01

    Nesiritide is a synthetic form of B-type natriuretic peptide. It is approved for the treatment of acute exacerbations of congestive heart failure in hospitalized adult patients. It is currently under investigation for use in other settings and other patient populations. This article describes administration of nesiritide to an infant patient with severe pulmonary hypertension and cor pulmonale. No adverse reactions occurred during administration of the drug. Specifically, there was no hypertension, vomiting, arrhythmia, or changes in renal function. No changes in renal function occurred in the months subsequent to treatment. This case report illustrates that nesiritide can be safely administered to critically ill infants with pulmonary hypertension and cor pulmonale. Our patient experienced a decrease in pulmonary pressure and improved clinical condition during and after the infusion. However, further study is required to fully evaluate the safety and efficacy of nesiritide for these patients.

  2. Noninvasive method to assess cor pulmonale in patients with chronic obstructive pulmonary disease

    Energy Technology Data Exchange (ETDEWEB)

    Yamaoka, S.; Yonekura, Y.; Koide, H.; Ohi, M.; Kuno, K.

    1987-07-01

    In our study of 15 patients with chronic obstructive pulmonary disease, we performed myocardial perfusion single-photon-emission computerized tomography (SPECT) with thallium-201 to quantitatively assess right ventricular hypertrophy. On the SPECT images, we determined the ratio of activity in the right-to-left ventricular wall as the thallium score. Right ventricular ejection fraction (RVEF) was measured by multigated equilibrium radionuclide ventriculography with krypton-81m. Both the thallium scores and RVEF values correlated well with pulmonary arterial pressure (r = 0.65 and r = -0.86, respectively) and permitted the structural and functional assessment of cor pulmonale. When the patients were classified according to the thallium scores and RVEF values, those who had both a high thallium score and reduced RVEF had a significantly high pulmonary arterial pressure and vice versa. The combined evaluation of the thallium score and RVEF enabled accurate noninvasive assessment of cor pulmonale.

  3. The Specific Characteristics in Children with Obstructive Sleep Apnea and Cor Pulmonale

    OpenAIRE

    Pi-Chang Lee; Betau Hwang; Wen-Jue Soong; C. C. Laura Meng

    2012-01-01

    Background. The prevalence of obstructive sleep apnea (OSA) in the pediatric population is currently estimated at 1-2% of all children. The purpose of this study was to investigate the clinical and hemodynamic characteristics in pediatric patients with cor pulmonale and OSA. Methods. Thirty children with the diagnosis of OSA were included. These patients consisted of 26 male and 4 female children with a mean age of 7 ± 4 years old. Five of those children were found to be associated with cor p...

  4. Assessment of the right and left ventricular function in patients with cor pulmonale using high-definition CT

    Institute of Scientific and Technical Information of China (English)

    GAO Yan; QIN Jian; DU Xiang-ying; YANG Jing; LI Kun-cheng

    2013-01-01

    Background Cor pulmonale is often associated with changes of structure and function of the right ventricle (RV) and thus further affects functional changes of the left heart.Our study aimed to assess the left ventricular (LV) and RV function in patients with cor pulmonale using high-definition CT (HDCT).Methods We prospectively studied 18 cor pulmonale patients determined by the pulmonary function test,clinical examination,chest radiograph,electrocardiogram,and echocardiogram.The subject group was compared to a control group consisting of 18 subjects.The RV and LV functions and RV myocardial mass (MM) were obtained by HDCT in the two groups.The results were compared between the two groups using the independent sample t test.Echocardiographic examination for cardiac function analysis was performed on the same day.Results The RV end-diastolic volume (EDV),RV end-systolic volume (ESV) and RV myocardial mass were significantly larger in the 18 cor pulmonale patients than in the control group (P<0.05).The right ventricular ejection fraction (RVEF) was significantly lower in the 18 cor pulmonale patients than in controls (P<0.01).The left ventricular EDV (LVEDV) and LVEF were significantly lower in cor pulmonale patients than in controls (P<0.01).There were strong correlations between MDCT and echocardiography,rRVEF=0.839 and rLVEF=0.916,respectively.Conclusions HDCT can accurately quantify RV and LV function.The right ventricular function is impaired in patients with cor pulmonale,while at the same time the left ventricular function is also impaired.

  5. Usefulness of thallium-201 myocardial perfusion scintigraphy in the diagnosis of chronic cor pulmonale

    Energy Technology Data Exchange (ETDEWEB)

    Kawai, S.; Tanaka, N.; Sawada, M.; Sakaguchi, K.; Fujita, K. (Osaka Prefectural Habikino Hospital, Osaka (Japan))

    1981-09-01

    To open up the possibility of exact clinical diagnoses of chronic cor pulmonale, we performed thallium-201 myocardial perfusion scintigraphy on patients with chronic pulmonary disease. From the thallium activity in the left ventricle (plus ventricular septum) and right ventricle counted scintigraphically, we determined the thallium activity ratio of left to right ventricle (TAR). The intra- and inter-observer variations of this ratio were negligible. We compared TAR with pulmonary hemodynamic findings and with left to right ventricular mass ratio measured at autopsy, and obtained the following results. 1) Left to right ventricular mass ratio determined in 11 autopsied patients by the method of Fulton et al. was closely correlated with TAR values (r = 0.90, p < 0.001). 2) In patients with chronic pulmonary disease, there were highly significant exponential inverse correlations between TAR and pulmonary arterial mean pressure, total pulmonary vascular resistance and right ventricular systolic pressure with the coefficients of -0.75, -0.72 or -0.77, respectively (p < 0.001). These results suggested the possibility that the severity of pulmonary circulatory disturbance may be ascertained non-invasively by TAR measurement. Thus, thallium-201 myocardial perfusion scintigraphy is able to reveal non-invasively right ventricular hypertrophy in patients with chronic pulmonary disease, and it might be a useful means of clinically diagnosing chronic cor pulmonale. If TAR obtained from scintigrams is smaller than 2, the patient concerned may possibly have right ventricular hypertrophy and he or she may be diagnosed as having chronic cor pulmonale.

  6. [Diuretic resistance and mechanical ventilation in decompensated cor pulmonale: successful treatment by slow continuous ultrafiltration].

    Science.gov (United States)

    Ries, W; Schenzer, A; Lüken, J; Ries, C; Machraoui, A

    2012-08-01

    We report on a 53-year-old male patient who presented with severe dyspnea at rest and massive volume overload because of decompensated cor pulmonale. Furthermore he suffered from stage 3 chronic kidney disease. As there was diuretics resistance and carbon dioxide narcosis, he had to be intubated and ventilated. The massive volume overload could be successfully treated with slow continuous ultrafiltration (SCUF) with removal of a volume of 27.5 l within 3 days. The SCUF therapy is an effective and gentle method to treat even an excessive volume overload based on diuretics resistance.

  7. Aerobic Exercise Promotes a Decrease in Right Ventricle Apoptotic Proteins in Experimental Cor Pulmonale.

    Science.gov (United States)

    Colombo, Rafael; Siqueira, Rafaela; Conzatti, Adriana; Fernandes, Tânia Regina Gattelli; Tavares, Angela Maria Vicente; Araújo, Alex Sander da Rosa; Belló-Klein, Adriane

    2015-09-01

    Pulmonary arterial hypertension is characterized by progressive increases in resistance and pressure in the pulmonary artery and Cor pulmonale. The effect of exercise on hydrogen peroxide-dependent signaling in the right ventricle (RV) of Cor pulmonale rats was analyzed. Rats were divided into sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), and trained monocrotaline (TM) groups. Rats underwent exercise training (60% of VO2 max) for 5 weeks, with 3 weeks after monocrotaline injection (60 mg/kg intraperitoneally). Pulmonary resistance was enhanced in SM (2.0-fold) compared with SC. Pulmonary artery pressure was increased in SM (2.7-fold) and TM (2.6-fold) compared with their respective controls (SC and TC). RV hypertrophy indexes increased in SM compared with SC. Hydrogen peroxide was higher in SM (1.7-fold) than SC and was reduced by 47% in TM compared with SM. p-Akt was increased in TM (2.98-fold) compared with SM. The Bax/Bcl-2 ratio and caspase 3 were also increased (2.9-fold and 3.9-fold, respectively) in SM compared with SC. Caspase 3 was decreased in TM compared with SM (P < 0.05). Therefore, exercise training promoted a beneficial response by decreasing hydrogen peroxide concentrations, and consequently, apoptotic signaling in RV.

  8. Quantitative evaluation of right ventricular overload in cor pulmonale using sup 201 Tl myocardial SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Hiroshi; Misawa, Toshihiro; Kutsumi, Yasunori (Fukui Medical School, Matsuoka (Japan)) (and others)

    1991-01-01

    To determine quantitatively the discriminant and characteristics of cor pulmonale, {sup 201}Tl myocardial perfusion SPECT was performed in 16 patients with chronic obstructive pulmonary disease (COPD) and 7 with restrictive pulmonary disease (RPD). One section of the short-axis SPECT image in which the right ventricle was most clearly visualized was selected. Tl-score was defined as the ratio of the sum of counts in the region of interest (ROI) at the anterior, mid, and posterior regions of the right ventricular free wall to the sum of counts in ROI at the posterior, lateral, and anterior walls of the left ventricle, and the anterior and posterior regions of the interventricular septum. In the group of COPD patients, Tl-score was positively correlated with mean pulmonary arterial pressure (mPAP), total pulmonary vascular resistance (TPR), and arterial carbon dioxide tension (PaCO{sub 2}), while it was inversely correlated with arterial oxygen tension (PaO{sub 2}). However, there was no significant correlation between Tl-score and mPAP, TPR, PaCO{sub 2}, and PaO{sub 2} in the group of RPD patients. In assessing pulmonary hypertension as defined by mPAP over 20 mmHg, a Tl-score greater than 0.25 was useful with a sensitivity of 69% and a specificity of 90%. The occurrence of cor pulmonale is a major factor in determining the prognosis of COPD patients. It was concluded that {sup 201}Tl myocardial SPECT is useful for evaluating right ventricular overload quantitatively, as well as for assessing core pulmonale, especially in COPD patients, since the ratio of Tl counts in the right and left ventricles was significantly correlated with right cardiopulmonary hemodynamic parameters. (N.K.).

  9. [Hemodynamics, blood gas composition and viscosity in patients with chronic obstructive bronchitis complicated by chronic cor pulmonale].

    Science.gov (United States)

    Verbitskiĭ, O N; Buturov, I V; Purkh, T Iu; Mohamed Fadi Fanari; Paraska, V I

    2004-01-01

    Hemodynamics, external respiratory function (ERF), blood gas composition and viscosity were studied in 120 patients with chronic obstructive bronchitis at different developmental stage of cor pulmonale. In pulmonary hypertension, there were moderate ERF disorders that became more marked in the compensatory and particularly decompensatory cor pulmonale. As bronchial patency deteriorated, the index of right ventricular performance increased from 0.76+0.081 to 1.23+0.022 in the examinees. Examination of blood gas composition revealed insignificant hypoxemia in pulmonary hypertension and compensatory cor pulmonale, which progressed with decompensation of chronic cor pulmonale (CCP). As bronchial obstruction progressed, there were increases in systolic, diastolic, and mean pressure in the pulmonary artery. The viscosity of blood and plasma and the indices of red blood cell aggregation and deformability were in the normal range in pulmonary hypertension and compensatory CCP. In CCP decompensation, the viscosity of blood and plasma and the index of red blood cell aggregation were increased and the index of red blood cell deformability was decreased.

  10. [RIGHT VENTRICULAR DIASTOLIC FUNCTION AND PERIPHERAL HEMODYNAMICS IN PATIENTS WITH CHRONIC COR PULMONALE RECEIVING VARIOUS THERAPY REGIMENS].

    Science.gov (United States)

    2010-01-01

    Right ventricular diastolic function, pulmonary hemodynamics, and peripheral endothelial vasoregulatory function were studied in patients with chronic cor pulmonale during complex treatment over time. The study confirmed the vasodilatory effect of ozone therapy and amlodipine during standard therapy, which appeared as lower blood pressure and better right ventricular diastolic function.

  11. Mixoma de átrio direito associado a cor pulmonale agudo: relato de caso Mixoma de atrio derecho asociado a cor pulmonale agudo: relato de caso Right atrial myxoma associated with acute cor pulmonale: case report

    Directory of Open Access Journals (Sweden)

    Michelle Nacur Lorentz

    2008-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os mixomas atriais são a forma mais comum de tumor intracardíaco primário. Apesar de serem tumores de comportamento benigno, recomenda-se que sejam retirados tão logo diagnosticados devido à possibilidade de embolização do tumor com suas nefastas conseqüências. O objetivo do presente relato foi apresentar um caso de tumor intracardíaco com localização rara (intra-atrial direito que apresentou embolização intra-operatória de parte do tumor e alertar os anestesiologistas para a possibilidade dessa complicação, além de discutir a conduta anestésica. RELATO DO CASO: Paciente do sexo masculino, 42 anos, portador de grande massa em átrio direito, submetido à retirada do tumor. A indução da anestesia foi feita com etomidato, fentanil e brometo de rocurônio e a manutenção, com isoflurano e fentanil. No intra-operatório o paciente apresentou quadro de cor pulmonale agudo em virtude da embolização de parte do tumor, sendo realizadas medidas de suporte e iniciada rapidamente a circulação extracorpórea. O restante da operação transcorreu bem e o paciente recebeu alta no sétimo dia pós-operatório em boas condições. CONCLUSÕES: Apesar do mixoma intracardíaco ser um tumor de características benignas, ele pode estar associado a complicações graves e às vezes fatais. O conhecimento da doença é importante para que o anestesiologista possa manusear de modo adequado esses pacientes, bem como diagnosticar e tratar as possíveis complicações intra-operatórias.JUSTIFICATIVA Y OBJETIVOS: Los mixomas atriales son la forma más común de tumor intracardiaco primario. A pesar de ser tumores de comportamiento benigno, se recomienda que sean retirados en cuanto sean diagnosticados debido a la posibilidad de embolización del tumor con sus nefastas consecuencias. El objetivo de este relato de caso fue presentar un caso de tumor intracardiaco con localización rara (intra-atrial derecho que present

  12. Cor Pulmonale

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930077 The aminophyllin and cefatoxin fortreatment pulmonary heart disease of mutual in-fluence.LI Shenqi(李胜岐),et al.2nd ClinColl Dept,China Med Univ,Shenyang 110003.Chin J Tuberd & Respir Dis 1992;15(5):272-273.The serum Aminophyllin(TP)and Cefatoxin(CTX)concentration of the patients with pul-monary heart disease during acute attack weremeasured by HLPC at 2 hrs and 6 hrs after infu-sion.(1)TP and CTX alone were used.(2)TPand CTX were used simultaneously.The resultshowed that the concentrations of TP weremuch higher,but those of CTX were much low-er when CTX and TP simultaneously,at 2 hrsand 6 hrs(P<0.01,P<0.05).The concentra-

  13. Cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    2010318 Diagnosis value of electrocardiogram in patients with pulmonary artery hypertension. ZHAO Qinhua(赵勤华),et al.Dept Pulm Cir,Shanghai Pulm Hosp,Tongji Univ,Shanghai 200433.Chin J Cardiol 2010;38(4):346-349. Objective To analyze the diagnostic value of electrocardiogram

  14. Cor pulmonale in a patient with Brown-Vialetto-Van Laere syndrome: a case report.

    Science.gov (United States)

    da Silva-Júnior, Francisco Pereira; Moura, Rafael de Deus; Rosemberg, Sérgio; Marchiori, Paulo Eurípedes; Castro, Luiz Henrique Martins

    2011-01-15

    Brown-Vialetto-Van Laere syndrome (BVVLS) is a rare neurological disease characterized by sensorineural hearing loss and multiple cranial nerve palsies, usually involving the VIIth and IXth to XIIth cranial nerves. We describe the clinical and pathological features of a 33-year-old woman with BVVLS. The patient developed progressive exertional dyspnea, with clinical and laboratory findings of right-sided heart failure and pulmonary hypertension. She developed status epilepticus in the setting of cardiac deterioration and respiratory infection, and died of cardiogenic and septic shock. Autopsy disclosed bilateral neuronal loss and gliosis in the inferior colliculi, locus coeruleus and facial and vestibular nuclei. Cor pulmonale is a complication of hypoventilation-induced hypoxia and hypercapnia and had not yet been reported in BVVLS.

  15. Deficiência de tiamina como causa de cor pulmonale reversível

    Directory of Open Access Journals (Sweden)

    Liana S. Coelho

    2008-07-01

    Full Text Available A deficiência de tiamina pode apresentar quatro formas clássicas de apresentação clínica: polineuropatia periférica, anorexia e fraqueza muscular (beribéri seco; insuficiência cardíaca de alto débito com sinais congestivos (beribéri úmido; beribéri associado ao choque (Shoshin beribéri e encefalopatia de Wernicke. Neste relato, descrevemos quadro sugestivo de hipertensão pulmonar grave e cor pulmonale, com estase jugular, hepatite congestiva e edema generalizado, que apresentou reversão completa após administração de tiamina.

  16. One-year prognosis and the role of brain natriuretic peptide levels in patients with chronic cor pulmonale.

    Science.gov (United States)

    Park, So Young; Lee, Chang Youl; Kim, Changhwan; Jang, Seung Hun; Park, Yong Bum; Park, Sunghoon; Hwang, Yong Il; Lee, Myung Goo; Jung, Ki-Suck; Kim, Dong-Gyu

    2015-04-01

    Data on the clinical outcomes and role of brain natriuretic peptide (BNP) levels in patients with chronic cor pulmonale are limited. A total of 69 patients with chronic cor pulmonale, admitted for dyspnea (January 2007 to September 2011) to three university hospitals, were retrospectively reviewed. All of the patients had right ventricular (RV) dysfunction on echocardiography. The median age was 70.0 yr, and chronic obstructive pulmonary disease (40.6%) and tuberculosis-destroyed lung (TDL, 27.5%) were the leading causes of chronic cor pulmonale. At the 1-yr follow-up, the mortality rate was 15.9%, and the readmission rate was 53.7%; patients with TDL had higher mortality (31.6% vs. 10.0%; P=0.059) and readmission rates (78.9% vs. 43.8%; P=0.009) than those with non-TDL diseases. The area under the receiver operating characteristic curve for admission BNP levels to predict readmission was 0.788 (95% confidence interval [CI], 0.673-0.904), and the sensitivity and specificity of the cut-off value were 80.6% and 77.4%, respectively. In multivariate analysis, high admission BNP levels were a significant risk factor for subsequent readmission (hazard ratio, 1.049; 95% CI, 1.005-1.094). Additionally, admission BNP levels were well correlated with cardiac troponin I (r=0.558), and delta BNP also correlated with delta RV systolic pressure (n=25; r=0.562). In conclusion, among hospitalized patients with chronic cor pulmonale, admission high BNP levels are a significant risk factor for subsequent readmission. Therefore, more intensive monitoring and treatment are needed in patients with higher BNP levels.

  17. Influence of blood viscosity on circulatory parameters determined by first-pass radionuclide angiocardiography in cor pulmonale

    Energy Technology Data Exchange (ETDEWEB)

    Zambo, K. [Dept. of Nuclear Medicine, Pecs (Hungary); Toth, K. [Dept. of Medicine, Div. of Cardiology Univ. Medical School, Pecs (Hungary)

    1993-12-01

    First-pass radionuclide angiocardiography (FPRNA) with {sup 99m}Tc-albumin was performed in 19 patients with cor pulmonale. Pulmonary circulation time (PCT), mean transit time (MTT), pulmonary stagnation index (PSI) were calculated from the time-activity curves for the estimation of cardiopulmonary circulation. Whole blood viscosity (WBV), plasma viscosity (PV) and hematocrit (HTC) were also measured on the same day. Significant prolongation of all parameters was observed (WBW: 5,04{+-}1.19 mPAS; PV: 1,36{+-}0,17 mPAS; HTC: 47,6{+-}2,37%; PCT: 7,10{+-}2,15 s; MTT: 9,33{+-}4,11 s; PSI: 1,30{+-}0,37) in patients with cor pulmonale. Significant positive correlations were found between PCT and WBV (r=0,552; 0,001Cor pulmonale durchgefuehrt. Pulmonale Zirkulationszeit (PCT), `mean transit` Zeit (MTT), pulmonaler Rest Index (PSI) wurden ermittelt aus den Zeit-Aktivitaetskurven zur Einschaetzung des kardiopulmonalen Durchflusses. Vollblut-Viskositaet (WBV), Plasma-Viskositaet (PV) und Haematokrit (HTC) wurden am selben Tage gemessen. Bezeichnend fuer Patienten mit Cor pulmonale war eine typische Vergroesserung aller Parameter (WBV: 5,04{+-}1,19 mPAS; PV: 1,36{+-}0,17 mPAS; HTC: 47,6{+-}2,37%; PCT: 7,10{+-}2,15 s; MTT: 9,33{+-}4,11 s; PSI: 1,30{+-}0,37). Verwertbare Korrelationen wurden zwischen PCT und WBV (r=0,552; 0,001

  18. COPD合并慢性肺源性心脏病与否的肺功能对比分析%Contrastive analysis of lung function in chronic obstructive pulmonary disease with and without chronic cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    王金祥; 胥振阳; 曾燕荣; 李晓辉; 刘宇毅

    2012-01-01

    Objective To analyze the differences of lung function between single (X)PD and (X)PD with cor pumonale patients. Methods Cardiac ultrasound and lung function examination were taken in all patients, and patients were enrolled into COLD stage Ⅱ ~ IV. Cases were divided into two groups due to whether or not combined with cor pulmonale, including COPD group( 37 cases ), and cor pirlmonale group( 3 1 cases ). Predicted values were used as a reference to assess various lung junction test parameters. Results Compared with COPD group, DLCO significantly decreased in cor pulmonale group(P 0. 05 ). Conclusion In cor pulmonale, pulmonary diffusing capacity was impaired more severe than COPD patients without cor pulmonale.%目的 通过对单纯COPD与肺心病患者的肺功能进行对比分析,了解COPD合并肺心病与否时的肺功能改变.方法 对所有入选的COPD患者进行肺功能和心脏超声检查,COPD患者GOLD分级为Ⅱ~Ⅳ级.根据有无肺心病将入选患者分为单纯COPD组和COPD合并肺心病组.单纯COPD组37例;COPD合并肺心病组31例.结果 COPD合并肺心病组DLCO% pred显著低于单纯COPD组(P<0.05);两组间FEV1% pred、FVC% pred、FEV1/FVC、RV% pred、TLC% pred、RV/TLC和共振频率无显著差异(P>0.05).结论 COPD合并肺心病患者较单纯COPD患者肺弥散功能的损害更为显著.

  19. CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC COR PULMONALE BY ANGIOTENSIN II RECEPTORS ANTAGONISTS

    Directory of Open Access Journals (Sweden)

    V. S. Zadionchenko

    2015-12-01

    Full Text Available Aim. To evaluate intensity of endothelial dysfunction, processes of apoptosis, state of central and peripheral hemodynamics and to evaluate how these characteristics are influenced by angiotensin II receptors antagonists (ARA II – candesartan (Atacand and losartan (Cosaar in patients with chronic cor pulmonale (CCP at different stages of disease.Material and methods. 100 patients with chronic obstructive pulmonary disease (COPD, complicated by CCP were included into the study. Caspase activity as apoptosis induction marker, von Willebrand factor, production of nitric oxide in blood plasma and condensate of breathing out air were assessed. 70 patients received ARA II (50 patients – candesartan 4-8 mg daily, 20 patients – losartan 50-100 mg daily, 30 patients received neither ARA II nor angiotensin converting enzyme inhibitors (ACEI.Results. Significant increase in intensity of endothelial dysfunction and activation of apoptosis processes were registered according to growth of CCP severity. After 6 months of therapy von Willebrand factor decreased by 25,2% and 27,7% in candesartan and losartan groups respectively (p<0.01 for both groups. In the control group only 13.2% of von Willebrand factor reduction was seen.Conclusion. ARA II added to common therapy of COPD complicated by CCP improves functional state of endothelium restricting hyperproduction of nitric oxide and its toxic effects and slowing down apoptotic cell death.

  20. CORRECTION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC COR PULMONALE BY ANGIOTENSIN II RECEPTORS ANTAGONISTS

    Directory of Open Access Journals (Sweden)

    V. S. Zadionchenko

    2007-01-01

    Full Text Available Aim. To evaluate intensity of endothelial dysfunction, processes of apoptosis, state of central and peripheral hemodynamics and to evaluate how these characteristics are influenced by angiotensin II receptors antagonists (ARA II – candesartan (Atacand and losartan (Cosaar in patients with chronic cor pulmonale (CCP at different stages of disease.Material and methods. 100 patients with chronic obstructive pulmonary disease (COPD, complicated by CCP were included into the study. Caspase activity as apoptosis induction marker, von Willebrand factor, production of nitric oxide in blood plasma and condensate of breathing out air were assessed. 70 patients received ARA II (50 patients – candesartan 4-8 mg daily, 20 patients – losartan 50-100 mg daily, 30 patients received neither ARA II nor angiotensin converting enzyme inhibitors (ACEI.Results. Significant increase in intensity of endothelial dysfunction and activation of apoptosis processes were registered according to growth of CCP severity. After 6 months of therapy von Willebrand factor decreased by 25,2% and 27,7% in candesartan and losartan groups respectively (p<0.01 for both groups. In the control group only 13.2% of von Willebrand factor reduction was seen.Conclusion. ARA II added to common therapy of COPD complicated by CCP improves functional state of endothelium restricting hyperproduction of nitric oxide and its toxic effects and slowing down apoptotic cell death.

  1. Acute cor pulmonale in ARDS: rationale for protecting the right ventricle.

    Science.gov (United States)

    Repessé, Xavier; Charron, Cyril; Vieillard-Baron, Antoine

    2015-01-01

    The ventilatory strategy for ARDS has been regularly amended over the last 40 years as knowledge of the pathophysiology of ARDS has increased. Initially focused mainly on the lung with the objectives of "opening the lung" and optimizing arterial oxygen saturation, this strategy now also takes into account pulmonary vascular injury and its effects on the right ventricle and on hemodynamics. Hemodynamic devices now available at the bedside, such as echocardiography, allow intensivists to evaluate respiratory settings according to right ventricular tolerance. Here, we review the pathophysiology of pulmonary vascular dysfunction in ARDS, consider the beneficial and deleterious effects of mechanical ventilation, describe the incidence and meaning of acute cor pulmonale based on recent studies in large series of patients, and propose a new, although not strictly validated, approach based on the protection of both the lung and right ventricle. One of our conclusions is that evaluating the right ventricle may help intensivists to assess the balance between recruitment and overdistension induced by the ventilatory strategy. Prone positioning with its beneficial effects on the lung and also on hemodynamics (the right ventricle) is a good illustration of this. Readers should be aware that most of the information given in this article reflects the point of view of the authors. Although based on clinical observations, clinical studies, and well-known pathophysiology, there is no evidence-based medicine to support this clinical commentary. Other approaches may be favored, in which case our article should be read as another attempt to help intensivists to improve management of ARDS.

  2. Anxiety in Patients with Chronic Cor Pulmonale and Its Effect on Exercise Capacity

    Directory of Open Access Journals (Sweden)

    Wenxin XU

    2016-10-01

    Full Text Available Background: Chronic cor pulmonale (CCP is a disease of increasing frequency in Chinese people and profoundly influences their health. CCP is often accompanied by anxiety and other psychological problems, and patients may show signs of motor function decline. However, little attention has been paid to the impact of CCP-related psychological problems on motor function.Methods: Patients with CCP receiving in- or outpatient treatment in the Respiratory Department of Xiangya Hospital of Central South University and the Second Xiangya Hospital of Central South University in Hunan Province between January and July 2015 were investigated. A total of 167 questionnaires were distributed, with 160 valid questionnaires ultimately collected from 95 male and 65 female participants of mean age (± standard deviation of 68.2 ± 12.3 yr. Self-Rating Anxiety Scale (SAS scoring was adopted to evaluate anxiety in the participants, and heart rate, blood pressure, breathing rate, 6-minute walk test and Borg index score were combined to detect the exercise capability of the participants.Results: Anxiety was present in 48.8% of patients. Heart rate, systolic blood pressure, breathing rate and the Borg score of CCP patients with anxiety were higher than in CCP patients without anxiety (P < 0.05, while mean walking distance was shorter (P < 0.05.Conclusion: The rate of anxiety in patients with CCP is relatively high. Anxiety reduces motor function in CCP patients; therefore, in the process of treating patients with CCP, effort should be made to engage simultaneously patients in psychotherapy.  

  3. Pulmonary alveolar microlithiasis with cor pulmonale: an autopsy case demonstrating a marked decrease in pulmonary vascular beds.

    Science.gov (United States)

    Terada, Tadashi

    2009-11-01

    Pulmonary alveolar microlithiasis (PAM) is a very rare autosomal recessive disorder in which microliths are formed in the alveolar space. PAM is infrequently complicated by pulmonary hypertension, the cause of which is unclear. The author in this paper found that the pulmonary hypertension was caused by a marked decrease in pulmonary vascular beds. Here, an autopsy case of PAM with a marked cor pulmonale is reported. A 14-year-old woman was found to have an abnormal pulmonary shadow, but the cause was unclear. At 24 years, she was diagnosed with a diffuse pulmonary abnormal shadow. At 42 years, she was diagnosed with PAM by imaging techniques. Her condition gradually worsened and she had to be treated with oxygen. She died of respiratory failure at 54 years. An autopsy revealed severe PAM and marked cor pulmonale. The heart weighed 360 g and right ventricular thickness was 10 mm (normal, 2-3 mm). Microscopically, the alveolar space was diffusely filled with microliths, and heart failure cells were recognized. Bone formations were scattered. The alveolar walls showed fibrous thickening, and pulmonary arteries showed atherosclerosis. The right ventricle showed marked cardiac hypertrophy. Chronic severe liver congestion was noted. A morphometric analysis using CD34-stained specimens showed a marked decrease (one tenth) in pulmonary capillary beds (capillary number: 8.6 +/- 3.1 per image), compared with normal lungs obtained from two other autopsies (85.3 +/- 9.4 and 96.2 +/- 10,3). It was concluded that the cor pulmonale and pulmonary hypertension in the present case were caused by the marked decrease of the pulmonary arterial vascular beds. More research is required regarding the etiology and treatment of PAM.

  4. A fatal case of cor pulmonale with undetected chronic hypoventilation in an infant with a known congenital myopathy.

    Science.gov (United States)

    Holst, John M; Willis, Mary J

    2012-01-01

    The authors of this paper wish to present a case of fatal cor pulmonale with right ventricular hypertrophy complicated by a congenital myopathy. It is our intention to demonstrate the importance of vigilant clinical assessment of children with a congenital myopathy, regardless of the exact etiology of their disease, or family history of disease severity. This case highlights the risk for fatal complications if hypoventilation and respiratory insufficiency go unrecognized in myopathic children. Consequently, we recommend respiratory and cardiac monitoring surveillance as well as appropriate referral to specialists in the management of such children.

  5. Resolution of cor pulmonale after medical management in a patient with cblC-type methylmalonic aciduria and homocystinuria: a case report.

    Science.gov (United States)

    Profitlich, Laurie; Kirmse, Brian; Wasserstein, Melissa P; Diaz, George; Srivastava, Shubhika

    2009-07-30

    We describe a 3-year-old Hispanic male with cblC-type methylmalonic aciduria and homocystinuria who presented to the emergency department with progressive tachypnea, vomiting, and edema secondary to pulmonary embolism and cor pulmonale. With aggressive medical management, there was complete resolution of right heart failure and pulmonary hypertension after 3 months. Pulmonary embolism is rare in the pediatric population. Children with cblC-type methylmalonic aciduria and homocystinuria may be at increased risk for thrombus formation and pulmonary embolism due to chronic hyperhomocystinemia, a risk factor for thrombus formation in the adult population. Aspirin therapy may be indicated in children with inborn errors of metabolism that predispose to hyperhomocystinemia.

  6. Effects of moxifloxacin on QT dispersion of cor pulmonale%莫西沙星对肺心病患者QT离散度的影响

    Institute of Scientific and Technical Information of China (English)

    罗雯; 霍建民; 张薇

    2012-01-01

    目的 研究喹诺酮类抗生素莫西沙星用于肺心病心功能失代偿期抗感染治疗时对其QT离散度( QTd)的影响,为肺心病抗感染治疗提供进一步研究资料.方法 将87例临床病例分为两组:肺心病观察组(n=60)和非肺心病对照组(n=27),记录其QTd及校正的QT离散度(QTcd),进行统计分析.再将上述病例分为三组,肺心病心功能失代偿期患者使用莫西沙星抗感染治疗组(n=29),肺心病心功能失代偿期患者使用β-内酰胺类抗生豪(哌拉西林/头孢哌酮)抗感染治疗(n=31),无肺心疾患的感染患者使用莫西沙星抗感染治疗(n=27),记录其用药前、用药2h和用药48 h的QTd及QTcd,并进行统计分析.结果 60例肺心病心功能失代偿期患者和27例非肺心病心功能失代偿期患者QTd和QTcd比较差异有显著统计学意义(P<0.01).29例肺心病心功能失代偿期患者使用莫西沙星抗感染治疗时,用药2h和用药48 h与用药前QTd和QTcd比较差异有显著统计学意义(P<0.01);用药48 h与用药2 h QTd和QTcd比较差异有统计学意义(P<0.05).31例肺心病心功能失代偿期患者使用β-内酰胺类抗生素抗感染治疗时,用药2h和用药48 h与用药前QTd和QTcd比较差异无统计学意义(P>0.05).27例无肺心疾患的感染患者使用莫西沙星抗感染治疗时,用药2h与用药前QTd和QTcd比较差异无统计学意义(P>0.05);用药48 h与用药前QTd和QTcd比较差异有统计学意义(P<0.05).结论 ①肺心病心功能失代偿期患者QTd、QTcd是增大延长的,往往QTd越大,预后越差.②莫西沙星具有增加QTd的作用,当有肺心病等潜在QT间期延长的危险因素时,更容易使其QTd增大延长.%Objective To investigate the effects of moxifloxacin on QT dispersion (QTd) of cor pulmonale,and to provide further evidences for anti-infection treatment of cor pulmonale.Methods 87patients were divided into two groups:cor pulmonale group ( n =60) and non-cor

  7. Esquistossomose pulmonar. II. Forma crônica reativada com hipertensão e Cor pulmonale

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    Jayme Neves

    1980-12-01

    Full Text Available Os Autores descrevem um caso grave de esquistossomose mansoni (forma hepática com hipertensão portal associada a forma pulmonar com hipertensão pulmonar e cor pulmonalej sobre o qual evoluiu uma sindrome toxi-infectuosa grave e de longa duração. Sucessivos exames radiológicos do tórax revelaram acometimento predominantemente arteriolar, ao lado de uma micronodulação pulmonar grosseira e difusa em ambos os hemitóraces e configuração de coração pulmonar. A histopatologia de material de biópsia pulmonar identificou basicamente uma arterite pulmonar característica, inflamação granulomatosa atípica provocada principalmente por vermes e raros ovos de S. mansoni envolvidos por escassa reação inflamatória. Para explicar a origem de constelação clínica toxi-infectuosa, foram afastadas as hipóteses de associação da esquistossomose a concausas infectuosas ou não, mas de curso febril, e a superposição de uma forma toxêmica sobre outra crônica pré-existente. Com base em dados clínicos, particularmente em subsídios da laparoscopia, e anatômicos, concluiu-se tratar o caso de uma forma crônica de esquistossomose reativada, provavelmente em virtude de alterações imunológicas inusitadas do hospedeiro. Ao que tudo parece indicar, o desvio de ovos e de vermes aos pulmões deveu-se à sindrome de hipertensão portal, cujos shunts entre a circulação portal e sistêmica determinaram a rota preferencial da migração.The Authors relate a case ofsevere schistosomiasis mansoni (hepatic form, with portal hypertension, associated with pulmonary form, with pulmonary hypertension and cor pulmonale, o ver which develloped a severe toxi-infectious syndrome of long duration. Serial chest X-rays showed that the arteriolae were predominantly affected, besides a gross and difuse pulmonary micronodulation in both hemithoraces, and pulmonary heart configuration. Histopathology of the pulmonary biopsy material identified basically a

  8. Electrical impedance tomography-guided prone positioning in a patient with acute cor pulmonale associated with severe acute respiratory distress syndrome.

    Science.gov (United States)

    Kotani, Toru; Tanabe, Hitoshi; Yusa, Hiroaki; Saito, Satoshi; Yamazaki, Kenji; Ozaki, Makoto

    2016-02-01

    Electrical impedance tomography (EIT) is a noninvasive technique used to assess regional gas distribution in the lung. We experienced a patient with acute cor pulmonale during high positive-pressure ventilation for the treatment of severe acute respiratory distress syndrome. Prone positioning was beneficial for unloading the right ventricle for treatment of acute cor pulmonale. EIT played a role in detecting lung derecruitment at the patient's bedside. Impedance distribution in ventral, mid-ventral, mid-dorsal, and dorsal layers before and 20 min after the start of prone positioning was 9, 48, 44, and 0 %, and 10, 25, 48, and 16 %, respectively. Lung recruitment monitored by EIT paralleled the improvement of PaO2/FIO2 from 123 to 239 mmHg. Timing of termination of prone positioning and ventilator settings such as lowering positive end-expiration pressure was determined to maintain dorsal recruitment as seen by EIT. The patient was weaned from mechanical ventilation on day 32 and discharged on day 200. EIT assessed the effects of prone positioning with real-time dynamic imaging and guided less injurious mechanical ventilation in a patient with acute cor pulmonale with dorsal lung derecruitment.

  9. The Study on QT Dispersion in the Patients With Cor Pulmonale%肺心病患者QT离散度的研究

    Institute of Scientific and Technical Information of China (English)

    赵立; 郭宏; 马淑梅; 杨德明; 马宗生; 谭朴泉

    2001-01-01

    目的:探讨肺心病及肺心病患者的心功能状态及低氧血症对QT间期离散度(QT离散度)的影响。方法:分析了51例肺心病患者及28例健康对照者的QT离散度、心电图、超声心动图及动脉血气分析。结果:肺心病患者的QT离散度显著高于正常对照者, 两组分别为(70.1 ± 25.8) ms 和(37.6 ± 12.5 )ms(P < 0.001);心衰患者的QT离散度延长更为明显, 为(87.9 ± 21.6) ms,无心衰患者为(51.7 ± 14.2) ms, 两组比较差异非常显著(P< 0.001);低氧血症对QT离散度有显著影响,动脉血氧分压(PaO2)< 8 kPa组和PaO2 ≥ 8kPa组QT离散度分别为(81.0 ± 25.9 )ms和(62.1 ± 21.2) ms ,两组比较有显著差异(P< 0.01);肺心病患者的QT离散度与右室内径大小显著正相关(r= 0.489,P< 0.01)。结论:QT离散度对于肺心病的辅助诊断及心功能判断具有一定的临床意义。%Objective:Our aim was to investigate the QT dispersion in patients with cor pulmonale and whether the QT dispersion was affected by cardiac function and hypoxemia of the patients with cor pulmonale. Methods:Fifty-one patients with cor pulmonale and 28 age-matched normal controls underwent electrocardiography, echocardiography, and arterial blood gas analysis. The QT dispersion was measured manually. Results:The QT dispersion was significantly longer in patients with cor pulmonale than those in the controls (70.1 ± 25.8 ms vs 37.6 ± 12.5 ms, P< 0.001). The QT dispersion in the patients with right heart failure was markedly longer compared with those with normal cardiac function (87.9 ± 21.6 ms vs 51.7 ± 14.2 ms, P<0.001). The QT dispersion was affected by hypoxemia. The QT dispersion in the groups of PaO2< 8 kPa or ≥ 8 kPa was 81.0 ± 25.9 ms and 62.1 ± 21.1 ms, respectively. There was significant difference between the groups (P< 0.01). The QT dispersion was significantly correlated with the

  10. Discussion on clinical characteristics of cor pulmonale in elderly with coronary heart disease%老年人肺心病合并冠心病临床探析

    Institute of Scientific and Technical Information of China (English)

    陈鹏

    2015-01-01

    目的::分析研究老年人肺心病合并冠心病的临床特点、症状以及检查情况,便于提高临床诊断以及治疗效果。方法:取样分析我院确诊收治的62例肺心病合并冠心病,分析其临床特点以及治疗效果。结果:研究分析表明,高龄以及病史延长者,预后效果不良。结论:老年肺心病合并冠心病患者的临床症状不典型,且老年患者随着年龄的增长,极易并发多种疾病,较难确诊具体的疾病,一旦确诊,需给予积极有效治疗,可显著提高患者生活质量水平。%Objective:To study the clinical characteristics of cor pulmonale in the elderly with coronary heart disease, symptoms, and check the situation, to improve the clinical diagnosis and therapeutic effect. Methods:The sample analysis of 62 cases of cor pulmonale with coronary heart disease were diagnosed and analyzed the clinical characteristics and treatment effects. Results:Analysis showed that age and medical history to extend, prognosis of adverse effect. Conclusion:The clinical symptoms in elderly patients with cor pulmonale with coronary heart disease may be not typical, and elderly patients with age, easily complicated by a variety of diseases, difficult to diag-nose specific disease, once diagnosed, should be given positive and effective treatment, can significantly improve patient quality of life.

  11. Clinical Analysis of Chronic Cor Pulmonale Complicating Arrhythmia%慢性肺源性心脏病并发心律失常临床分析

    Institute of Scientific and Technical Information of China (English)

    徐桂华; 夏辉

    2012-01-01

    Objective: To analyse the clinical features of chronic cor pulmonale complicating arrhythmi-a. Method: 158 cases patients treated in our hospital with chronic cor pulmonale, including arrhythmia group of 97 patients, non - arrhythmia group of 61 patients, They were griven conventional treatment, observed the type of arrhythmia and two groups were compared the incidence of concurrent symptoms. Result: The most common type of chronic cor pulmonale complicating arrhythmia is mainly sinus tachycardia ( 42. 27% ) and atrial premature beats ( 32.99% ); Pulmonary infection, heart failure, hypoxia, electrolyte imbalance were 100% , 44. 33% , 60. 82% , 73. 20% in arrhythmia group and 85. 25% ,18. 03% , 36. 07% , 52.46% in non-arrhythmia group. There's significant difference, P<0.01. Conclusion: Chronic cor pulmonale complicating arrhythmia occurs with age , infection, hypoxia, electrolyte imbalance , heart failure and other factors, timely appropriate treatment can effectively reduce the mortality.%目的:分析慢性肺源性心脏病并发心律失常的临床特征.方法:将我院治疗的慢性肺心病患者158例,其中心律失常组97例,非心律失常组61例,给予常规治疗,观察心律失常的类型,比较两组并发症状发生情况.结果:肺源性心脏病并发心律失常最常见的类型主要为窦性心动过速(42.27%)及房性早搏(32.99%);心律失常组并发肺部感染、心力衰竭、缺氧、电解质紊乱分别为100%、44.33%、60.82%、73.20%,与非心律失常组85.25%、18.03%、36.07%、52.46%比较,有统计学差异,P<0.01.结论:肺源性心脏病并发心律失常的发生与年龄、感染、缺氧、电解质紊乱、心力衰竭等因素有关,及时给予相应的治疗能够有效地降低病死率.

  12. Obstructive sleep apnea with pulmonary hypertension and cor-pulmonale in an 11-year-old Nigerian boy with sino-nasal non-hodgkin lymphoma

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    Ibrahim Aliyu

    2014-01-01

    Full Text Available Children are predominantly nasal breathers, therefore obstruction of the nasal passage presents early with difficulty in breathing; however, with advance in age they soon adapt to mouth breathing. Chronic upper airway obstruction may result in cardiovascular complications such as pulmonary hypertension, right ventricular heart failure, and also renal disease. Therefore, we report the case of an 11-year-old Nigerian boy who had upper airway obstruction complicated with sleep apnea, pulmonary hypertension and cor-pulmonale resulting from sino-nasal (nasopharyngeal non-Hodgkin lymphoma which is rare in African children

  13. Study On The Traditional Chinese Medicine Of Cor Pulmonale%肺心病缓解期的中药运用规律研究

    Institute of Scientific and Technical Information of China (English)

    柏正平; 胡学军; 谭光波; 王帅; 甘荣; 柏莹

    2012-01-01

    目的:通过文献研究,探讨肺心痛缓解期的中药运用规律;方法:检索国内近15年( 1996 -2010)现有中医及中西医结合期刊杂志肺心痛缓解期研究的有关报道,对本病处方用药方法进行分析、总结,提炼整理出本病的中药运用规律;结果:在符合纳入标准的151首方剂中,涉及中药85味,运用频次最高的药物分别是补气药(频率22.6%)、止咳化痰药(频率为17.4%)、活血化瘀药(频率12.1%),其次为利水渗湿药、清热药、补血药、解表药、补阳药、理气药、收涩药等.结论:近代临床医师在肺心痛缓解期的中药运用中,以补虚为主,泻实为次,注重益气温(补)阳、活血化瘀、化痰降浊三法的综合运用,注重调理和改善肺、脾、肾三脏功能.%Objective: Analyzes the traditional Chinese medicine of cor pulmonale through the literature research. Method: Search clinical reports about cor pulmonale in TCM or Chinese and Western integration domestic literatures from 1996 to 2010, statistics the law of the traditional Chinese medicines of cor pulmonale. Result: There are 85 traditional Chinese medicines in the 151 Qualified TCM Prescriptions. The highest used frequencies of of the traditional Chinese medicines are qi invigorating drugs (22.6% ), Antitussive and Phlegm drugs (17.4% ), Blood - activating and Stasis -eliminating Drugs(12.1% ) ,the next drugs are damp - draining diuretic, heat - clearing drugs, blood - tonifying drugs, exterior — releasing drugs, yang — tonifying drugs, qi - regulating drugs, astringent drugs. Conclusion: Tonifying and replenishing medicine is more import than reducing excessiveness medicine in traditional Chinese medicine to Cor Pulmonale. We should pay attention to the comprehensive application of invigorating qi and wanning yang, activating blood and resolving stasis, resolving phlegm and lowering chaotic. Conditioning the lungs,the spleen and the kidney.

  14. HU Sirong distinguishes key points of treating cor pulmonale heart failure%胡思荣辨治肺心病心衰

    Institute of Scientific and Technical Information of China (English)

    左明晏

    2016-01-01

    胡思荣教授从事中、西医临床及科研工作40余年,积累了丰富的医疗经验。胡师精于仲景学说,兼通温病各家诸说,擅长运用相关理论辨治肺心病心衰。提倡从痰饮论治肺心病心衰,认为肺心病阳虚为本,痰饮为基本病因,以温化痰饮为主--务,灵活运用温药除其湿,采用中病既止之法则。%Professor HU Sirong engaged in clinical and scientific research between Chinese and western medicine more than 40 years,has accumulated rich experience in health care. Hu teacher skilled in zhang zhongjing theory,and warm disease all said,are good at using relevant theory of treating cor pulmonale heart failure. Advocates from phlegm retention differentiation of cor pulmonale heart failure,thought that Yang deficiency and phlegm retention as the basic etiology,phlegm drink warm as the main priority,and flexible use of medicine in addition to the wet warm,adopt the rules of disease in both check.

  15. Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9.

    Science.gov (United States)

    Yan, Shuangquan; Wang, Yiran; Liu, Panpan; Chen, Ali; Chen, Mayun; Yao, Dan; Xu, Xiaomei; Wang, Liangxing; Huang, Xiaoying

    2016-01-01

    Baicalin has a protective effect on hypoxia-induced pulmonary hypertension in rats, but the mechanism of this effect remains unclear. Thus, investigating the potential mechanism of this effect was the aim of the present study. Model rats that display hypoxic pulmonary hypertension and cor pulmonale under control conditions were successfully generated. We measured a series of indicators to observe the levels of pulmonary arterial hypertension, pulmonary arteriole remodeling, and right ventricular remodeling. We assessed the activation of p38 mitogen-activated protein kinase (MAPK) in the pulmonary arteriole walls and pulmonary tissue homogenates using immunohistochemistry and western blot analyses, respectively. The matrix metalloproteinase- (MMP-) 9 protein and mRNA levels in the pulmonary arteriole walls were measured using immunohistochemistry and in situ hybridization. Our results demonstrated that baicalin not only reduced p38 MAPK activation in both the pulmonary arteriole walls and tissue homogenates but also downregulated the protein and mRNA expression levels of MMP-9 in the pulmonary arteriole walls. This downregulation was accompanied by the attenuation of pulmonary hypertension, arteriole remodeling, and right ventricular remodeling. These results suggest that baicalin may attenuate pulmonary hypertension and cor pulmonale, which are induced by chronic hypoxia, by downregulating the p38 MAPK/MMP-9 pathway.

  16. Baicalin Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension to Improve Hypoxic Cor Pulmonale by Reducing the Activity of the p38 MAPK Signaling Pathway and MMP-9

    Directory of Open Access Journals (Sweden)

    Shuangquan Yan

    2016-01-01

    Full Text Available Baicalin has a protective effect on hypoxia-induced pulmonary hypertension in rats, but the mechanism of this effect remains unclear. Thus, investigating the potential mechanism of this effect was the aim of the present study. Model rats that display hypoxic pulmonary hypertension and cor pulmonale under control conditions were successfully generated. We measured a series of indicators to observe the levels of pulmonary arterial hypertension, pulmonary arteriole remodeling, and right ventricular remodeling. We assessed the activation of p38 mitogen-activated protein kinase (MAPK in the pulmonary arteriole walls and pulmonary tissue homogenates using immunohistochemistry and western blot analyses, respectively. The matrix metalloproteinase- (MMP- 9 protein and mRNA levels in the pulmonary arteriole walls were measured using immunohistochemistry and in situ hybridization. Our results demonstrated that baicalin not only reduced p38 MAPK activation in both the pulmonary arteriole walls and tissue homogenates but also downregulated the protein and mRNA expression levels of MMP-9 in the pulmonary arteriole walls. This downregulation was accompanied by the attenuation of pulmonary hypertension, arteriole remodeling, and right ventricular remodeling. These results suggest that baicalin may attenuate pulmonary hypertension and cor pulmonale, which are induced by chronic hypoxia, by downregulating the p38 MAPK/MMP-9 pathway.

  17. 足三里择时穴位按摩对COPD肺心病胃肠功能的影响%Impact of Zusanli massage timing on gastrointestinal function in patients with cor pulmonale complicating COPD

    Institute of Scientific and Technical Information of China (English)

    邓丽金; 郑丽维; 李壮苗; 危椠罡

    2012-01-01

    目的 探讨改善COPD肺心病患者胃肠功能的有效方法.方法 将60例COPD肺心病伴胃肠功能障碍患者随机分为观察组和对照组各30例.两组均行常规护理,观察组在此基础上,选择足三里于辰时(8:00~9:00)和亥时(21:00~22:00)进行穴位按摩,每次10~15 min.干预2个月后比较两组患者胃肠功能障碍(腹胀、食欲不振、排便困难或腹泻)改善情况.结果 观察组治疗效果显著优于对照组(P<0.01).结论 根据子午流注理论进行足三里择时按摩可有效改善COPD肺心病患者的胃肠功能.%Objective To explore an effective method for improving gastrointestinal function of patients with cor pulmonale complicating COPD. Methods Sixty patients with cor pulmonale due to COPD were randomly divided into an observation group and a control group of 30. Both groups received routine nursing care, while participants in the observation group were additionally given acupoint massage to Zusanli in the morning (8:00 — 9,00) and at night (21:00 —22:00)for 10—15 min per time. After 2 months' intervention, gastrointestinal dys function (abdominal distension, poor appetite, difficult defecation or diarrhea) of both groups was compared. Results The curative effect in the observation group was significantly better than that in the control group (P<0. 01). Conclusion According to the Midnight-noon ebb-flow theory, appropriate Zusanli massage timing can effectively improve gastrointestinal function of patients with cor pulmonale complicating COPD.

  18. 老年肺心病合并冠心病患者临床治疗研究%In elderly patients with cor pulmonale with coronary heart disease clinical research

    Institute of Scientific and Technical Information of China (English)

    李晓文

    2015-01-01

    With the rapid development of society, the elderly cor pulmonale with increasing number of patients with coronary heart disease symptoms, this article in view of the old patients with cor pulmonale with coronary heart disease symptoms and diagnosis methods, and combined with their own clinical experience of the symptoms, hope to improve the senile cor pulmonale with the effect of clinical diagnosis and treatment of coronary heart disease, to improve the clinical treatment of senile cor pulmonale with coronary heart disease provide effective feasible Suggestions.%随着社会的快速发展,老年群体肺心病合并冠心病症状患者数量日益增加,本文针对老年肺心病合并冠心病患者症状及诊断方法,并结合自身的临床经验对该症状进行阐述,希望提高老年肺心病合并冠心病临床诊断和治疗的效果。试图为提高老年肺心病合并冠心病的临床治疗提供行之有效的可行性建议。

  19. 肺心病合并脑梗死患者血液流变及血气分析%Blood Rheology and Blood Gas Analysis Effect in Patients with Cor Pulmonale Combination Cerebral Infarction

    Institute of Scientific and Technical Information of China (English)

    米娜瓦尔·艾麦提

    2013-01-01

    目的:探讨肺心病合并脑梗死患者的血液流变和动脉血气的改变。方法:选取近期来本院就诊的肺心病患者58例,脑梗死患者62例,肺心病合并脑梗死患者48例,同时,另选50例健康老年人作为健康对照组。对所有患者进行全血粘度、血浆粘度、血沉、红细胞压积和纤维蛋白原检测,并计算红细胞聚集指数等血流变指标。测定氧分压、二氧化碳分压、第一秒用力呼气容积等肺功能指标,比较各组患者各指标的差异。结果:肺心病合并脑梗死组患者血流变各指标明显高于对照组、脑梗死组和肺心病组(P<0.01);肺心病合并脑梗死组患者的PaO2、FEV1明显低于对照组、脑梗死组和肺心病组(P<0.01),而肺心病合并脑梗死组患者的PaCO2均高于其他三组(P<0.01)。结论:肺心病和脑梗死对正常血液流变及肺功能的损害存在交互作用,血液流变和动脉血气检测对肺心病合并脑梗死的诊断及治疗有一定的指导意义。%Objective:To study arterial blood gas and blood rheology in patients with cor pulmonale combination cerebral infarction.Method:58 patients who suffered Cor Pulmonale,62 patients who suffered cerebral infarction and 48 patients with cor pulmonale combination cerebral infarction were selected.50 healthy old people were selected as a healthy control group at the same time.For all patients with whole blood viscosity,plasma viscosity,blood sedimentation,red blood cells deposited and fibrinogen detection,indexes such as red blood cell aggregation index were all calculated. Determination of oxygen partial pressure,CO2 partial pressure,the first second forced expiratory volume,which were the indices of pulmonary function to compare the difference between the groups of patients with various indicators.Result:The indexes of blood rheology in cor pulmonale combination cerebral infarction patients group was obviously higher than

  20. 试论慢性肺心病以瘀为本%A Discussion on the Treatment of Chronic Cor Pulmonale by Dealing with Removing Blood Stasis

    Institute of Scientific and Technical Information of China (English)

    汤伟

    2001-01-01

    Cor pulmonale is one of intractable dis eases in clinical practice. The author considered that the pathogennic factor of the disease is a complication of phlegm, blood stasis and debility, with blood stasis as the chief pathogenesis. Its basic treatment should be activat ing blood circulation and removing blood stasis, associat ed with expelling sputum, or invigorating debility or clearing heat.%肺心病是临床常见的难治证之一。认为在肺心病痰瘀虚交互错杂的基础上,以“瘀”为最基本和最主要的病机,治疗上以活血化瘀为基础,或佐豁痰、补虚、清热等法。

  1. Management of the Acute Attack of Chronic Cor Pulmonale%慢性肺源性心脏病发作期的处理

    Institute of Scientific and Technical Information of China (English)

    蔡映云

    2000-01-01

    @@ 肺源性心脏病是指由于肺和胸廓疾病或肺血管病变引起的肺动脉高压,致使右心室肥大、扩大或右心衰竭的心脏病.根据病程缓急可分急性和慢性.临床上我们常见的慢性肺源性心脏病(Chronic cor pulmonale)(以下简称肺心病),多由慢性支气管炎和阻塞性肺气肿引起,约占74.7%~88.1%.

  2. 肺心病缓解期的中医证型研究%Study On TCM Syndrome Type Of Cor Pulmonale

    Institute of Scientific and Technical Information of China (English)

    胡学军; 柏正平; 王帅; 甘荣

    2012-01-01

    Objective: To analyze the characteristics of TCM syndrome type of cor pulmonale through the literature research. Method: Search clinical reports about cor pulmonale in TCM or Chinese and Western integration domestic literatures from 1996 to 2010, summarize the characteristics of distribution of TCM syndrome types. Result; There are 62 TCM syndrome types in these literatures. The highest frequency of the TCM syndrome types are Qi deficiency and blood stasis syndrome, phlegm and blood stasis syndrome, deficiency of both spleen and kidney,deficiency of both lung and kidney, deficiency of lung - Qi syndrome, yang deficiency and blood stasis syndrome, deficiency of kidney syndrome, deficiency of both lung and spleen, phlegm - heat obstructing lungs and water invading the lung and heart syndrome. These account for 89.1% of all TCM syndrome types of cor pulmonale. Conclusion; The deficiency types and root deficiency and branch excess types are import in TCM syndrome types of cor pulmonale. The most common deficiency types are deficiency of both spleen and kidney, deficiency of both lung and kidney, deficiency of lung - Qi types. Qi deficiency and blood stasis type are important in root deficiency and branch excess types and phlegm and blood stasis type are important in excessive syndrome.%目的:通过文献研究,探讨肺心病缓解期的中医证型特点;方法:检索国内近15年(1996 -2010)现有中医及中西医结合期刊杂志肺心痛缓解期研究的有关报道,统计分析其证型分布特点.结果:在纳入271篇文献中共出现62个证型,其中出现频率较高的前10项证型分别是气虚血瘀、痰瘀互结、脾肾两虚、肺肾两虚、肺气亏虚、阳虚血瘀、肾虚失纳、肺脾两虚、痰热壅肺和水凌心肺,其累计频率为89.1%.结论:肺心痛缓解的中医证候以单纯本虚为多,本虚标实和标实证候也不少见.本虚以脾肾两虚、肺肾两虚、肺气亏虚最为常见;本虚标实以气虚血

  3. Paracoccidioidomicose pulmonar agressiva, endotraqueíte estenosante e cor-pulmonale subagudo: descrição de um caso

    Directory of Open Access Journals (Sweden)

    E. P. Campos

    1986-06-01

    Full Text Available A paracoccidioidomicose (Pbmicose atinge os pulmões pela via inalatória, onde se estabelece o complexo primário semelhante ao da tuberculose. A traquéia comprometida pela via tubohemolinfática desenvolveria reação inflamatória em processo granulomatoso levando à obstrução estenosante com asíixia. Acompanhou-se um doente, masculino, 32 anos, branco, natural de Sarutaiá (SP, lavrador, que há 8 meses desenvolveu tosse expectorativa branco-amarelada, diária, sem fatores de melhora ou piora e dispnéia inicial discreta. Há 4 meses, anorexia, fraqueza e astenia. Há 1 mês a dispneia se agravou. Perdeu 15 kg. Tabagista e etilista há 16 anos. Exame físico revelou: PA — 10/7 mmHg, FR = 28 bpm, peso 31 kg, hipocratismo digital e hipotrofia muscular Tórax enfisematoso e síndrome obstrutivo aos testes de função pulmonar. Coração: P2 desdobrada e hiperfonética. Hepatesplenomegalia. Desenvolveu cor-pulmonale e insuficiência adrenal à internação, evoluindo após 45 dias para óbito em insuficiência respiratória aguda asfixiante, apesar da terapia antifúngica ter sido completa. A literatura médica revista não mostrou registro de caso semelhante de cor-pulmonale e insuficiência adrenal de evolução subaguda.

  4. Histopathology of explanted AlphaCor due to keratoprosthesis extrusion.

    Science.gov (United States)

    Caporossi, Aldo; Mazzotta, Cosimo; Balestrazzi, Angelo; Occhini, Rossella; Toti, Paolo; Traversi, Claudio

    2006-07-01

    AlphaCor keratoprosthesis (KPro) is a new-concept poly (2-hydroxyethyl methacrylate) one-piece KPro that makes possible a two-step implantation technique easy to perform with a short learning curve. In literature an 18% incidence of AlphaCor removal due to melting complications is reported. The histopathology of corneal tissue removed during a re-operation while bearing an AlphaCor KPro has previously been described in the literature only in one report. Herein, the first histological features of an AlphaCor-corneal complex explanted because of KPro extrusion is described. The histopathology of the AlphaCor-corneal complex is characterized by mild inflammation in the corneal tissues, limited to the region surrounding the anteriorized and extruded part of the KPro. It is not possible to fully understand the mechanisms that trigger the device extrusion. One possible explanation could be a dislocation of the prosthesis in the corneal pocket due to the untied fixation stitch. Another explanation could be a foreign body reaction induced by KPro.

  5. 老年肺心病合并心律失常29例临床分析%The clinical analysis of 29 cases cor pulmonale old patients combined with arrhythmia

    Institute of Scientific and Technical Information of China (English)

    孙红

    2014-01-01

    ObjectiveTo explore the clinical characteristics of old patients with cor pulmonale and arrhythmia,in order to provide clinical experience of prevention and treatment for cor pulmonale patients with arrhythmia.Methods Retrospectively analyzed the clinical data of 61 cases elderly cor pulmonale patients from May 2009 to May 2014 in our hospital, statistics the incidence of arrhythmia and distribution of the proportion of all kinds of arrhythmia, and observed the relationship between cardiac arrhythmias and cardiac function and electrolyte disorder.Results 29 cases out of 61 cases of elderly patients who suffered from cor pulmonale merged arrhythmia, the incidence of arrhythmia was 47.54%. The type of arrhythmia mainly was atrial premature beat,10 cases, accounting for 34.48%; center function of 2 cases out of 29 patients with cor pulmonale and arrhythmia was classification into classⅠ, accounting for 6.9%; Ⅱ level were 4 cases, accounting for 13.79%; Ⅲ level were 11 cases, accounting for 37.93%; Ⅳ grade were 12 cases, accounting for 44.82%. In the 29 patients with cor pulmonale and arrhythmia , 11 cases were decompensated acidosis, accounting for 37.93%; 10 cases were hypokalemia, accounting for 34.48%; 8 cases were Hyponatremia, accounting for 27.58%.ConclusionElderly patients with cor pulmonale have greater risk of arrhythmia, cor pulmonale with arrhythmia is closely related to the hypoxemia, cardiac function and electrolyte disorders, clinical comprehensive measures should be taken for treatment.%目的:探讨老年肺心病合并心律失常临床特点,为肺心病合并心律失常的防治提供临床经验。方法回顾性分析2009年5月~2014年5月我院收治的61例老年肺心病患者临床资料,统计心律失常发生率及各种类型心律失常分布构成比,观察心律失常与心功能和电解质紊乱的关系。结果61例老年肺心病患者中合并心律失常29例,心律失常发生率为47.54%。心律失

  6. Acute pulmonary embolism: prediction of cor pulmonale and short-term patient survival from assessment of cardiac dimensions in routine multidetector-row CT; Mehrschicht-Spiral-CT bei vermuteter und inzidenteller akuter Lungenembolie: prognostischer Wert morpholoqischer Herzparameter

    Energy Technology Data Exchange (ETDEWEB)

    Engeike, C. [Radiologie, Klinikum rechts der Isar der Technischen Univ. Muenchen (Germany); Rummeny, E.; Marten, K. [Inst. fuer Roentgendiagnostik, Klinikum rechts der Isar der Technischen Univ. Muenchen (Germany)

    2006-10-15

    Purpose: evaluation of the prognostic value of morphological cardiac parameters in patients with suspected and incidental acute pulmonary embolism (PE) using multidetector-row chest CT (MSCT). Materials and methods: 2335 consecutive MSCT scans were evaluated for the presence of PE. The arterial enhancement and analysability of pulmonary arteries and the heart were assessed as parameters of the scan quality. The diastolic right and left ventricular short axes (RV{sub D}, LV{sub D}) and the interventricular septal deviation (ISD) were measured in all PE-positive patients and the echocardiography reports were reviewed. The clinical data assessment included cardio-respiratory and other co-morbidities, systemic anticoagulant therapy (ACT), and the 30-day outcome. Predictors of acute cor pulmonale and the short-term outcome were calculated by univariate and multivariate logistic regressions including odds ratios (OR) and ROC analyses using positive (PPV) and negative predictive values (NPV). Results: 90 patients with acute PE were included (36 with clinically suspected PE, 54 with incidental PE). 26 patients had cardio-respiratory co-morbidities. Four patients underwent systemic thrombolysis, 43 underwent anticoagulation in therapeutic doses, 19 underwent anticoagulation in prophylactic doses, and 24 patients did not undergo ACT. 15 of 41 patients had echocardiographic evidence of acute cor pulmonale. 8 patients died within 30 days. The RV{sub D} was the best independent predictor of acute cor pulmonale (p = 0,002, OR = 9.16, PPV = 0.68, NPV=1 at 4.49 cm cut off) and short-term outcome (p= 0,0005, OR = 2.82, PPV = 0.23, NPV = 0.98 at 4.75 cm cut off). The RV{sub D}/LV{sub D} ratio had a PPV of 0.85 for cor pulmonale. (orig.)

  7. 肺心病急性发作期血糖观察探讨%Cor Pulmonale with Acute Episodes Glucose to Observe

    Institute of Scientific and Technical Information of China (English)

    王漫丽

    2015-01-01

    Objective To observe the cor pulmonale with acute episodes blood sugar levels. Methods From May 2014 to May 2014 patients of cor pulmonale, 100 patients with acute phase, review the clinical data for analysis. Results The hy-perglycemia group case fatality rate was 20.00%, no high blood glucose group was 5.00%, hyperglycemia group were signif-icantly higher than those without a high blood glucose group (P<0.05). High blood glucose group was in the hospital for an average of d (14.33+1.67), no (9.67-1.26) for high blood sugar group d, high blood glucose significantly longer than without high blood glucose group (P<0.05). Breathing, heart failure, fasting hyperglycemia group, the incidence of postprandial hy-perglycemia are 23.68% and 23.68% respectively, without breathing, heart failure group were 6.45%, 16.13%, breathing, heart failure group were significantly higher than those without breathing, heart failure group (P<0.05). Conclusion The cor pulmonale patients with acute phase may occur high blood sugar, high blood glucose will influence on the course and prog-nosis, observe the blood sugar level, and take active treatment.%目的:观察肺心病急性发作期血糖水平。方法选取从2014年5月-2015年5月收治的肺心病急性发作期患者100例,回顾分析其临床资料。结果高血糖组病死率为20.00%,无高血糖组为5.00%,高血糖组明显高于无高血糖组(P<0.05)。高血糖组住院时间平均为(14.33±1.67)d,无高血糖组为(9.67±1.26)d,高血糖组明显长于无高血糖组(P<0.05)。呼吸、心力衰竭组空腹高血糖、餐后高血糖发生率分别为23.68%、39.47%,无呼吸、心力衰竭组分别为6.45%、16.13%,呼吸、心力衰竭组明显高于无呼吸、心力衰竭组(P<0.05)。结论肺心病急性发作期患者可能会发生高血糖,高血糖会对病程、预后产生影响,注意观察血糖水平,并采取积极治疗。

  8. Effect of Yiqi Huoxue(益气活血) Herbs on Vascular Endothelial Cells and Platelets in Patients with Chronic Cor Pulmonale

    Institute of Scientific and Technical Information of China (English)

    王伟; 徐少华; 张颖; 王辉; 邵红艳; 王殿辉

    2004-01-01

    Objective: To observe the clinical effect of Yiqi Huoxue (益气活血, YQHX) herbs in treating the patients with chronic cor pulmonale and to explore its mechanism by determining the relationship of oxidation/antioxidation system and how such herbs change on the function of endothelial cells and platelets. Methods: Fifty-eight patients were divided into two groups: conventional therapy group (control group, 28 paventional management. The treated group were treated with YQHX 150 ml, twice a day, plus the conventional treatment, and the clinical efficacy was recorded. The lipid peroxidation (LPO), superoxide dismutase (SOD), α-granule membrane protein (GMP140), partial pressure of arterial oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2) and circulating endothelial cells (CEC) were measured respectively before and after treatment, and the relationship between various parameters were analyzed. The results were compared with those of 10 healthy subjects got at the same period. Results: (1) The effective rate and PaO2 of the treated group was higher than that of the control group and there were no difference in PaCO2 between the two groups. (2) The levels of LPO, GMP140, CEC in all the patients before therapy were significantly higher than those of the healthy group, and there were marked decrease in the levels of those after treatment (all P<0. 01). On the contrary, the levels of SOD in all the patients before therapy were markedly lower than those in the healthy subjects and increased after treatment, P<0.01. (3) The increase of SOD in the treated group was significantly more obvious than that of the control group. In the treated group, the decrease of LPO, GMP140, CEC were markedly more obvious than those in the control group (all P<0.01).(4) The number of CEC, as well as GMP140, was negatively correlated to PaO2 (P<0.01) and SOD (P<0.01), which was positively correlated to LPO (P<0.01). There was a positive correlation between CEC

  9. Effect of Yiqi Huoxue (益气活血) Herbs on Vascular Endothelial Cells and Platelets in Patients with Chronic Cor Pulmonale

    Institute of Scientific and Technical Information of China (English)

    王伟; 徐少华; 张颖; 王辉; 邵红艳; 王殿辉

    2004-01-01

    Objective: To observe the clinical effect of Yiqi Huoxue (益气活血, YQHX) herbs in treating the patients with chronic cor pulmonale and to explore its mechanism by determining the relationship of oxidation/antioxidation system and how such herbs change on the function of endothelial cells and platelets. Methotis: Fifty-eight patients were divided into two groups: conventional therapy group (control group, 28 patients) and convention plus YQHX herbs group (treated group, 30 patients). The control group received conventional management. The treated group were treated with YQHX 150 ml, twice a day, plus the conventional treatment, and the clinical efficacy was recorded. The lipid peroxidation (LPO), superoxide dismutase (SOD), α-granule membrane protein (GMP140), partial pressure of arterial oxygen (PaO2), partial pressure of carbon dioxide in artery (PaCO2) and circulating endothelial cells (CEC) were measured respectively before and after treatment, and the relationship between various parameters were analyzed. The results were compared with those of 10 healthy subjects got at the same period. Results: (1) The effective rate and PaO2 of the treated group was higher than that of the control group and there were no difference in PaCO2 between the two groups. (2) The levels of LPO, GMP140, CEC in all the patients before therapy were significantly higher than those of the healthy group, and there were marked decrease in the levels of those after treatment (all P<0.01). On the contrary, the levels of SOD in all the patients before therapy were markedly lower than those in the healthy subjects and increased after treatment, P<0.01. (3) The increase of SOD in the treated group was significantly more obvious than that of the control group. In the treated group, the decrease of LPO, GMP140, CEC were markedly more obvious than those in the control group (all P<0.01). (4) The number of CEC, as well as GMP140, was negatively correlated to PaO2 (P<0.01) and SOD (P<0

  10. 探讨慢性肺源性心脏病急性加重期的临床护理对策%Clinical nursing countermeasure of chronic cor pulmonale with acute aggravating period

    Institute of Scientific and Technical Information of China (English)

    贾汝

    2014-01-01

    目的:应用全面护理模式对急性加重期慢性肺源性心脏病患者实施的护理效果进行研究。方法选择在我院就诊的急性加重期慢性肺源性心脏病患者82例,随机分为对照组和观察组,各41例。对照组采用常规护理模式;观察组采用全面护理模式。结果观察组患者对慢性肺源性心脏病急性加重期护理模式的满意度明显高于对照组;治疗时间明显短于对照组。结论应用全面护理模式对急性加重期慢性肺源性心脏病患者实施的护理效果非常明显。%Objective To apply the comprehensive nursing mode on condition of patients with acute aggravating period of chronic cor pulmonale implementation of nursing clinical effect were studied. Methods In the condition of our hospital in 82 patients with acute aggravating period of chronic cor pulmonale patients, randomly divided into control group and observation group, an average of 41 cases in each group. The conventional nursing care model to control the implementation of nursing;Observation group to implement the comprehensive nursing pattern on the nursing care. Results The observation group of patients of chronic cor pulmonale with acute aggravating period of the nursing mode satisfaction is signiifcantly higher than control group;Cor pulmonale clinical treatment time signiifcantly shorter than the control group.Conclusion Comprehensive nursing model was applied to the illness of patients with acute aggravating period of chronic cor pulmonale implementation of nursing clinical effect is very obvious.

  11. 慢性阻塞性肺疾病合并肺源性心脏病危险相关因素分析%Analysis of the Risk Factors in Chronic Obstructive Pulmonary Disease Combined with Cor Pulmonale

    Institute of Scientific and Technical Information of China (English)

    单湘湘; 周建平; 范仁根; 任向东

    2015-01-01

    目的::探讨慢性阻塞性肺疾病( COPD)合并肺源性心脏病危险相关因素。方法:选取50例慢性阻塞性肺疾病合并肺源性心脏病住院患者作为研究组,同时选取同期COPD未合并肺源性心脏病住院患者作为对照组,分析COPD患者发生肺心病的危险因素。结果:研究组患者在PaO2、 PaCO2、 CD4+/CD8+、 FEV1及FEV1/FVC方面均差于对照组,差异有统计学意义(P<0.05)。疾病加重次数、吸烟指数及SGRQ评分是慢性阻塞性肺疾病合并肺源性心脏病的危险因素。结论:稳定患者病情,减少COPD急性发作次数,戒烟,及时疏导患者负性心理有利于降低慢性阻塞性肺疾病合并肺源性心脏病的危险性,提高患者生活质量,改善预后。%OBJECTIVE: To analyse the risk factors in chronic obstructive pulmonary disease ( COPD) combined with cor pul-monale. METHODS: 50 hospitalized patients with COPD combined with cor pulmonale were as the study group and oither hospitalized patients only with COPD during the same period were as the control group. The risk factors of cor pulmonale in the patients with COPD were analysed. RESULTS: The levels of PaO2 , PaCO2 , CD4 + /CD8 +, FEV1 and FEV1/FVC were lower in the studly group than those in the control group. There was statistically significant difference (P<0. 05). Degree of diseases, smoking index and SGRQ scores were the risk factors of COPD combined with cor pulmonale. CONCLUSION: To stabilize the disease, decrease the times of the onset of COPD and give up smoking can decrease the risk of COPD combined with cor pulmonale. And the methods above may also im-prove the quality of life and the prognosis of the patients.

  12. 肺心病患者左右心功能的MRI研究%Assessment of the Right and Left Ventricular Function in Patients with Cor Pulmonale Using MRI

    Institute of Scientific and Technical Information of China (English)

    高艳; 李坤成; 秦俭; 杜祥颖; 尹建国; 杨旗

    2012-01-01

    目的 探讨MRI评价肺心病患者左、右心功能的应用价值.资料与方法 前瞻性研究18例经肺功能实验、临床检查、X线、心电图、超声心动图等影像学检查证实为合并慢性阻塞性肺病(COPD)的肺心病患者,另选取18名健康志愿者作为对照组.采用1.5 T MRI仪测量两组左、右室心功能及右室心肌质量.采用独立样本t检验测量两组间差异是否有统计学意义.结果 2例肺心病患者MRI检查时由于屏气时间长、不能配合而排除.与对照组比较,16例肺心病患者右室(right ventricle,RV)舒张末期容积(end-diastolic volume,EDV)、右室收缩末期容积( end-systolic volume,ESV)及右室心肌质量(myocardial mass,MM)明显增加(P<0.05),而右室射血分数(ejection fraction,EF)明显减低(P<0.01).左室EDV及EF显著减低(P<0.01).结论 肺心病患者随着肺动脉压升高,超过右心室的代偿能力,促使右心室扩大和右心功能衰竭,同时左心功能损伤.MRI左右心功能的测量可以评价肺心病的严重程度,为临床提供治疗的客观依据.%Objective To assess the left and right ventricular ( RV) function in patients with cor pulmonale using Magnetic resonance imaging (MRI). Materials and Methods Eighteen cor pulmonale patients determined by the pulmonary function test, clinical examination, chest radiographs, electrocardiogram and echocardiogram were prospectively studied. The control group consisted of 18 age-matched, healthy, nonsmoking subjects. The RV and LV function and RV myocardial mass (MM) were obtained by 1.5 T cardiac MRI in two groups. The results between the two groups were compared using the independent sample t test. Results Two patients who were unable to perform repeated breath holding during MRI acquisition were excluded from the study. The RV end-diastolic volume (EDV) , RV end-systolic volume (ESV) and RV myocardial mass (MM) were significantly larger in 16 cor pulmonale patients than in control

  13. The System of Neutrophil Elastase and the Plasma Level of MMP-7 in Children with Pulmonary Arterial Hypertension and Chronic Cor Pulmonale

    Directory of Open Access Journals (Sweden)

    Еlena M. Vasilyeva

    2014-03-01

    Full Text Available A significant increase in the activity of neutrophil elastase (NE and anti-NE-protection in the plasma were detected in children having bronchopulmonary dysplasia (BPD complicated by pulmonary arterial hypertension (PAH and chronic cor pulmonale (CCP. The changes revealed were more pronounced in patients with CCP. The plasma concentration of the NE was slightly reduced, which was probably associated with the activation of anti-NE and an increase in the α1-antitrypsin level. A gradual increase was noted in the plasma level of the matrix metalloproteinase-7 (MMP-7 in patients with an increase in the severity of the condition. In patients with cystic fibrosis (with and without CCP, the pronounced increase in the MMP-7 level was observed. In patients with cystic fibrosis (CF, even without the additional complication with PAH and CCP, the MMP-7 level was significantly higher than in those with congenital broncho-pulmonary malformations (CBPM. The difference was increased in those patients with PAH and reached a maximum in those with CCP.

  14. 老年肺心病患者应用高频通气膈肌起搏的疗效观察%Effects of high frequency ventilation diaphagm pacemaker in aged patients with cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    冯长顺; 林海丽; 原援

    2001-01-01

    Objective: To find out an effective way of the rehabilitation treatment in aged patients with cor pulmonale. Method: 30 cases of aged patients with cor pulmonale in rehabilitation stage were treated with high frequency ventilation diaphagm pacemaker(HDP). Result:The PaO2 and lung function were significantly improved and the level of the plasma endothelin - 1 was significantly lowered after the rehabilitation treatment. Conclusion: HDP is a safe and effective way to patients with cot pulmonale for convalescent treatment.%目的:寻求老年肺心病患者康复治疗的有效方法。方法:应用高频通气膈肌起搏对30例老年肺心病患者进行了康复治疗的疗效观察。结果:老年肺心病患者经高频通气膈肌起搏康复治疗后,PaO2增高,肺功能改善,血浆内皮素-1水平明显降低,与治疗前比较有显著性差异(P<0.01)。结论:高频通气膈肌起搏是老年肺心病患者一种安全、有效的康复治疗方法。

  15. The clinical observation and nursing of chronic cor pulmonale combined with acute myocardial infarction patients%慢性肺心病合并急性心肌梗死的临床观察及护理

    Institute of Scientific and Technical Information of China (English)

    陈少娟; 江月娥; 段红萍; 卢小玲

    2009-01-01

    目的 通过对慢性肺心病合并急性心肌梗死(AMI)的临床表现、体征的观察,探讨其临床特点,总结护理经验.方法 对慢性肺心病合并AMI 28例(A组)患者临床表现进行观察分析,以同期收治的单纯性肺心病28例(B组)作对照.结果 两组胸闷、胃肠道反应症状发生率无显著性差异.而肺心病合并AMI的患者突发急性左心衰、心源性休克、持续性心律失常、胸痛的发生率明显高于单纯性肺心病.结论 重视老年性肺心病的临床症状、体征的观察,高度注意肺心病合并AMI特别是无痛性AMI的发生,及早发现急性左心衰、心源性休克、持续性心律失常、胸痛等临床症状和体征,早诊断、早治疗,落实正确的护理措施,对疾病预后至关重要,能有效地降低病死率.%Objective To study the clinical feature and nursing of chronic cor pulmonale combined with acute myocardial infarction (AMI) patients. Methods The clinical manifestation of chronic cor pulmonale combined with AMI patients (28 cases) and chronic cot pulmonale patients (28 cases) were analyzed. Results The incidence rates of chest tightness and the symptom of gastro - intestinal tract had no significant difference. But the incidence rates of acute heart failure, cardiac shock, continuous arrhythmia, chest pain in chronic cot pulmonale combined with AMI patients were higher than those in chronic cot pulmonale patients. Conclusions Pay more attention to observing the clinical manifestation and symptom of chronic cot pulmonale patiens especially for the occurrence of pninless AMI. Diagnosis and treatment earlier and the correct nursing measures can reduce the mortality effectively.

  16. The mesurements of calcitonin gene-related peptide and substance P in patients with chronic cor pulmonale%慢性肺源性心脏病患者血浆CGRP和SP水平的测定

    Institute of Scientific and Technical Information of China (English)

    王珍珍; 谢新立; 阮翘

    2010-01-01

    目的 探讨血浆降钙素基因相关肽(calcitonin gene-related peptide,CGRP)和P物质(substance P, SP)在慢性肺源性心脏病(肺心病)发生发展中的病理生理作用.方法 采用放射免疫分析法测定30例肺心病组急性发作期和治疗后缓解期及20例正常对照组血浆CGRP和SP 浓度.肺心病组同时检测动脉氧分压(PaO2).结果 血浆CGRP水平肺心病组急性发作期(12±5)pg/ml和治疗后缓解期(19±7)pg/ml均低于正常对照组(24±5)pg/ml,差异有统计学意义(P0.05).PaO2急性发作期和治疗后缓解期分别为(6.3±2.0)kPa、(9.5±1.6)kPa,差异有统计学意义(P<0.01).结论 慢性缺氧与血浆CGRP、SP水平下降有关,尤其是CGRP,缺氧时两者的变化共同促进了肺动脉高压的形成,在慢性肺源性心脏病发生发展中起重要作用.%Objective To evaluate the pathophysiological role of calcitonin gene-related peptide(CGRP) and substance P(SP) in patients with chronic cor pulmonale. Methods The levels of plasma CGRP and SP were determined by radioimmunoassay in 30 patients with chronic cor pulmonale before and after treatment, and their mean pulmonary aterial pressure(PaO2) were detected. Control group consisted of 20 healthy subjects and the levels of plasma CGRP and cor pulmonale group, plasma CGRP levels before treatment(12±5 pg/ml)were lower than those after treatment(19±7)pg/ml(P<0.01). Both of them were lower than those in control group(24±5)pg/ml(P<0.01). Plasma SP levels before treatment(39±12)pg/ml were significantly lower than those after treatment(46±11)pg/ml (P<0.01), and control group(45±8)pg/ml(P<0.05), and there after treatment in chronic cor pulmonale group, PaO2 were (6.3±2.0)kPa and (9.5±1.6)kPa respectively, the former was significantly lower than the latter(P<0.01). Conclusions This study suggests that hypoxia has a statistical relationship with the decrease of plasma CGRP and SP levels in patients with chronic cor pulmonale, particularly with

  17. The effect of holistic nursing care on chronic cor pulmonale%整体护理对慢性肺源性心脏病的效果分析

    Institute of Scientific and Technical Information of China (English)

    谢艳玲; 付小清

    2011-01-01

    目的 探讨慢性肺源性心脏病患者实施整体护理的方法及临床效果.方法 2006年1月至2008年5月我院收治的慢性肺源性心脏病患者80例随机分为观察组40例(整体护理)和对照组40例(常规护理),对两组的临床效果进行比较.结果 经过治疗与护理,两组的总有效率、血常规、血气分析相比均具有显著性差异(P<0.05).结论 对慢性肺源性心脏病患者实施系统的整体护理措施,可以防止和减少临床并发症的发生,提高慢性肺源性心脏病患者的临床疗效,有效促进患者康复.%Objective To explore the clinical effect of holistic nursing on chronic cor pulmonale.Methods From January 2006 to may 2008 80chronic cor pulmonale patients were randomly divided into observation group in 40 cases (holistic nursing) and control group in 40 cases (conventional care). The clinical effects were compared between two groups.Results After therapy and nursing, two group total effectiveness, blood tests, blood gas analysis were compared with significant difference (P<0.05).Conclusions Chronic cor pulmonale patients are treated with holistic nursing measures, which can prevent and reduce clinical complications, improve the clinical curative effect, effectively promote the patient recover.

  18. Esquistossomose pulmonar. II. Forma crônica reativada com hipertensão e Cor pulmonale

    Directory of Open Access Journals (Sweden)

    Jayme Neves

    1980-12-01

    Full Text Available Os Autores descrevem um caso grave de esquistossomose mansoni (forma hepática com hipertensão portal associada a forma pulmonar com hipertensão pulmonar e cor pulmonalej sobre o qual evoluiu uma sindrome toxi-infectuosa grave e de longa duração. Sucessivos exames radiológicos do tórax revelaram acometimento predominantemente arteriolar, ao lado de uma micronodulação pulmonar grosseira e difusa em ambos os hemitóraces e configuração de coração pulmonar. A histopatologia de material de biópsia pulmonar identificou basicamente uma arterite pulmonar característica, inflamação granulomatosa atípica provocada principalmente por vermes e raros ovos de S. mansoni envolvidos por escassa reação inflamatória. Para explicar a origem de constelação clínica toxi-infectuosa, foram afastadas as hipóteses de associação da esquistossomose a concausas infectuosas ou não, mas de curso febril, e a superposição de uma forma toxêmica sobre outra crônica pré-existente. Com base em dados clínicos, particularmente em subsídios da laparoscopia, e anatômicos, concluiu-se tratar o caso de uma forma crônica de esquistossomose reativada, provavelmente em virtude de alterações imunológicas inusitadas do hospedeiro. Ao que tudo parece indicar, o desvio de ovos e de vermes aos pulmões deveu-se à sindrome de hipertensão portal, cujos shunts entre a circulação portal e sistêmica determinaram a rota preferencial da migração.

  19. 老年呼吸道感染合并肺心病右心衰竭的护理探讨%Elderly Respiratory Infection Merged Cor Pulmonale Right Heart Failure Care to Discuss

    Institute of Scientific and Technical Information of China (English)

    秦玉梅

    2015-01-01

    Objective To study the elderly respiratory infection merged the nursing methods of cor pulmonale right heart failure.Methods Selected 66 patients with respiratory tract infection merged cor pulmonale right heart failure are comprehensive nursing, the nursing effect.Results The nursing in patients with the total effective rate was 98.5% and the incidence of complications was 98.5%.Conclusion Comprehensive nursing in patients with the class can not only improve the treatment efficiency, reduce the incidence of complications.%目的:探讨老年呼吸道感染合并肺心病右心衰竭的护理方法。方法选取呼吸道感染合并肺心病右心衰竭患者66例均进行综合护理,观察护理效果。结果患者的护理总有效率为98.5%和并发症发生率为3.03%。结论对该类患者实施综合护理不仅能够提高治疗的有效率,也可降低并发症的发生率。

  20. Tei指数对老年慢性肺源性心脏病患者右心功能的评价%Evaluation on Tei index for right heart function of elderly patients with chronic cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    李霞

    2013-01-01

    目的探析T ei指数对老年慢性肺源性心脏病患者右心功能的评价作用。方法对本院2009年3月至2012年3月收治的疑似慢性肺源性心脏病老年患者98例(A组)和同期体检健康老年人群68例(B组)进行超声检查和T ei指数测量。超声检查指标有右室内径、右房横径、肺动脉主干内径、右室前壁厚度和肺动脉收缩压(SPAP)。结果 A组患者中31例(31.6%)具有明确的肺心病超声征象,42例(42.9%)患者未见明确肺心病超声征象,但存在三尖瓣和(或)肺动脉瓣反流,27例(25.5%)患者既未见明确肺心病超声征象,又未见三尖瓣或肺动脉瓣反流,三类患者 Tei指数均显著高于B组人群(P<0.05)。结论 Tei指数能够反映患者右心功能,可做为评价病情的敏感指标。%Objective To study the evaluation function of Tei index for right heart function of elderly patients with chronic cor pulmonale .Methods Choosed 98 cases of elderly patients suspected chronic cor pulmonale and 68 cases of the medical health elder-ly population from March 2009 to March 2012 in our hospital as group A and B ,ultrasonic inspection and Tei index were measured , ultrasonic inspection indicators contains ,right room transverse diameter ,the main pulmonary artery diameter ,wall thickness and be-fore in pulmonary artery systolic pressure .Results A group of 31 patients(31 .6% ) with a clear cor pulmonale ultrasonic signs ,42 patients(42 .9% ) did not see clearly cor pulmonale ultrasonic signs ,but there was three tricuspid valve and (or) pulmonary valve re-gurgitation ,27 cases(25 .5% ) patients were not seen clear cor pulmonale ultrasonic signs ,and did not see the tricuspid valve and pulmonary valve regurgitation ,three types of Tei index patients were significantly higher than the group B (P<0 .05) .Conclusion Tei index can reflect patients right heart function and can be used as a sensitive index

  1. NT-proBNP对呼吸衰竭、慢性肺源性心脏病的预后评估价值%Prognostic evaluation value of NT-proBNP in respiratory failure and chronic cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    刘艺菲; 杜道兵

    2015-01-01

    目的 观察NT-proBNP在呼吸衰竭及慢性肺源性心脏病合并呼吸衰竭患者中的水平变化,评价NT-proBNP对呼吸衰竭、呼吸衰竭并慢性肺源性心脏病的严重程度、预后评估的价值.方法 选择2012年1月至2013年12月我科收治的55例呼吸衰竭患者,50例呼吸衰竭并慢性肺心病患者,测定入院时NT-proBNP血清浓度,比较两组患者NT-proBNP数值变化,再次以NT-proBNP 2000 pg/ml为截点,分为两组(A组为浓度高者,B组为浓度低者),观察两组患者住院天数、8个月内不良事件发生数.结果 呼吸衰竭并慢性肺心病患者NT-proBNP水平显著高于呼吸衰竭患者,差异有统计学意义(P<0.05),NT-proBNP≥2000 pg/ml组8月内不良事件发生率高,差异有统计学意义(P<0.01).结论 NT-proBNP水平变化对呼吸衰竭、慢性肺源性心脏病诊断及预后有一定的临床评价意义.%Objective To observe serum NT-proBNP level in patients with respiratory failure (RF) and patients with RF combined with chronic cor pulmonale,investigate the value of NT-proBNP in evaluation of severity and prognosis in RF and RF combined with chronic cor pulmonale.Methods 55 cases of RF and 50 cases of RF combined with chronic cor pulmonale in our department from Jan.2012 to Dec.2013 were selected.Tested and compared serum NT-proBNP concentration in two groups.All patients were divided into two groups according to serum NT-proBNP concentration (group A:serum NT-proBNP concentration ≥ 2000 pg/ml; group B:serum NT-proBNP concentration < 2000 pg/ml).Hospitalization day and the incidence of adverse events within 8 months were compared between two groups.Results Serum NT-proBNP concentration in patients with RF combined with chronic cor pulmonale was significantly higher than that in patients with RF (P < 0.05).The rate of adverse events within 8 months in group A was significantly higher than that in group B (P < 0.01).Conclusion Serum NT-proBNP concentration is helpful

  2. 肺源性心脏病合并冠心病75例临床分析%Analysis on 75 cases of cor pulmonale combined with coronary heart disease

    Institute of Scientific and Technical Information of China (English)

    刘雅芸; 鲁保龙; 宋福莲

    2013-01-01

    目的:研究肺源性心脏病合并冠心病的临床特点。方法以我院收治的75例肺源性心脏病合并冠心病患者作为观察组,并以同期收治的75例单纯肺源性心脏病患者作为对照组,回顾性分析比较两组患者的临床资料。结果观察组在心绞痛(84.0%)、心悸(92.0%)、心肌梗死(17.3%)、心界向左扩大(28.0%)、呼吸困难(57.3%)、缺血型ST-T改变(84.0%)、电轴左偏(33.3%)、束支传导阻滞(18.7%)、陈旧性心肌梗死(14.7%)等临床表现和心电图结果方面与对照组差异有统计学意义(P<0.05)。经过有效的治疗,两组患者均恢复良好,没有并发严重的不良反应。结论肺源性心脏病合并冠心病是一种较为复杂的疾病,临床表现众多,对于该病及时有效的诊治显得极为重要。%Objective To study the clinical characteristics of cor pulmonale combined with coronary heart disease. Methods Seventy-five cases of cor pulmonale combined with coronary heart disease admitted into our hospital were selected as the observation group, and 75 cases of cor pulmonale admitted during the corresponding period were selected as the control group. The clinical data of two groups were retrospectively analyzed and compared. Results In the observation group, the clinical manifestations and ECG results were angina (84.0%), palmus (92.0%), myocardial infarction (17.3%), heart border enlarging toward left (28.0%), dyspnea (57.3%), ischemic ST-T changes (84.0%), left axis deviation (33.3%), bundle branch block (18.7%) and old myocardial infarction (14.7%), which had significant differences compared with in the control group(P < 0.05). After the effective treatment, the patients of two groups recovered well without serious adverse reactions. Conclusion Cor pulmonale combined with coronary heart disease is a complex disease which has many clinical manifestations. So, timely and effective diagnosis and

  3. Expression levels of induced sputum IL-8 and IL-10 and drug intervention effects in patients with acute exacerbated COPD complicated with chronic cor pulmonale at high altitude.

    Science.gov (United States)

    Feng, Enzhi; Wan, Ronghua; Yang, Shengyue; Yan, Ziqiang; Wang, Shaolin; He, Wei; Zhang, Ying; Yin, He; Chen, Zongru; Liu, Ruinian

    2013-09-01

    The aim of this study was to assess the expression levels of induced sputum interleukin (IL)-8 and IL-10 levels in patients with acute exacerbated chronic obstructive pulmonary disease (AECOPD) complicated with chronic cor pulmonale (CCP) at high altitude, and to evaluate the intervention effects of an inhaled corticosteroid (ICS) and a β2-adrenoceptor agonist in this disease. A total of 186 patients with AECOPD complicated with CCP were randomly divided into three groups, with 62 cases in each. With regard to the two treatment groups, group A was treated with salmeterol/fluticasone (50 μg/250 μg, respectively) by airway inhalation twice daily, while group B received budesonide (1 mg) as a spray inhalation, twice daily. The routine treatment group (group C) received only routine treatment. The levels of IL-8 and IL-10 in the induced sputum and the predicted percentage of forced expiratory volume in one second (FEV1%pred), partial pressure of oxygen in arterial blood (PaO2) and partial pressure of carbon dioxide in arterial blood (PaCO2) were examined on admission and at a stable stage two weeks following treatment. Forty healthy volunteers served as a control group (group D). Compared with group D values, the IL-8 induced sputum level and the PaCO2 were significantly increased, while the level of IL-10, FEV1%pred and the PaO2 were markedly decreased in the three COPD groups prior to treatment. Following treatment, the induced sputum IL-8 level and the PaCO2 were significantly decreased, while the induced sputum IL-10 level, FEV1%pred and the PaO2 were markedly increased in the three treatment groups compared with the values pre-therapy (all P<0.01). The post-treatment parameters were significantly different among the three groups (P<0.01). The results indicate that IL-8 and IL-10 are involved in the airway inflammation of AECOPD complicated by CCP. Treatment with an ICS was demonstrated to be a successful method of reducing the local expression of IL-8 and

  4. 蝮蛇抗栓酶治疗肺心病急性发作32例疗效观察%Therapeutic Effect of Ahylysantinfarctase on 32Cases with the Acute Episode of Chronic Cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    蔡远玲; 张乃芬; 周红坚

    2000-01-01

    Objective: To study the therapeutic effect of Ahylysantinfarctase on acute episode of chronic cor pulmonale. Method: Using Ahylysantinfaretase with other therapeutic measures to treat 32 cases with acute episode of chronic cor pulrnonale. Results: Of 32 cases treated by Ahylysantinfarctase, 20 cases show a prominent effect and 9 cases are better than before. The total effective rate reaches 90.6% in the test group (the group treated by Ahylysantinfarctase) while only 65.6% in the control group. The curative effect in the test group is much better than that in the control group (P<0.05). Conclusion: The application of Ahylysanfinfarctase has provided an effective method for treating cor pulmonale.%目的:探讨蝮蛇抗栓酶在治疗肺心病急性发作中的临床应用价值。方法:采用蝮蛇抗栓酶联合其它综合措施治疗肺心病急性发作32例。结果:蝮蛇抗栓酶组32例显效20例,有效9例,总有效率达90.6%;对照组总有效率仅达65.6%。蝮蛇抗栓酶组疗效明显高于对照组(P<0.05)。结论:蝮蛇抗栓酶的应用为治疗肺心病提供了有效的方法。

  5. Echocardiography of isolated subacute left heart tamponade in a patient with cor pulmonale and circumferential pericardial effusion.

    Science.gov (United States)

    Mars, Tomaz; Mikolavcic, Helena; Salobir, Barbara; Podbregar, Matej

    2010-07-14

    Patients with advanced idiopathic pulmonary artery hypertension have often a chronic pericardial effusion. It is the result of increased transudation and impaired re-absorption due to elevated venous pressure. These patients have pre-existent symptoms and signs of chronic right heart failure. High degree of suspicion is required to detect of development of an atypical form of tamponade with isolated compression of left heart chambers as shown in present case report. Transthoracic echocardiography provides a rapid access to the correct diagnosis, a prompt relief of symptoms following the ultrasound guided pericardiocentesis and important diagnostic tool for regular follow up of patients thereafter as shown in our case report.

  6. Echocardiography of isolated subacute left heart tamponade in a patient with cor pulmonale and circumferential pericardial effusion

    Directory of Open Access Journals (Sweden)

    Salobir Barbara

    2010-07-01

    Full Text Available Abstract Patients with advanced idiopathic pulmonary artery hypertension have often a chronic pericardial effusion. It is the result of increased transudation and impaired re-absorption due to elevated venous pressure. These patients have pre-existent symptoms and signs of chronic right heart failure. High degree of suspicion is required to detect of development of an atypical form of tamponade with isolated compression of left heart chambers as shown in present case report. Transthoracic echocardiography provides a rapid access to the correct diagnosis, a prompt relief of symptoms following the ultrasound guided pericardiocentesis and important diagnostic tool for regular follow up of patients thereafter as shown in our case report.

  7. 血浆B型脑钠肽水平在慢性肺源性心脏病诊断中的作用%Role of plasma B-type brain natriuretic peptide level in diagnosis of chronic cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    吴颖; 高蔚; 施斌

    2016-01-01

    Objective To investigate the diagnostic value of plasma B-type brain natriuretic peptide(BNP) level in chronic cor pulmonale by detecting plasma BNP level in the patients with chronic dyspnea. Methods Two hundreds and sixty-four inpa-tients with chronic dyspnea in the respiration department and cardiology department of our hospital from March 2014 to April 2015 were selected and divided into the simple pulmonary disease group (100 cases),chronic cor pulmonale group (89 cases) and left cardiac failure group(75 cases) based on the clinical data,clinical manifestations and related detection results. The levels of plasma BNP in each group were measured by immunofluorometric assay. Chest X-ray and electrocardiogram(EKG) examinations were also performed in all the cases. Results (1)The plasma BNP levels in the simple pulmonary disease group,cor pulmonale group and left cardiac failure group were (83.26±14.84),(330.24±38.10),(1 180.73±100.51)pg/mL respectively,the differences in inter-group pairwise comparison showed statistical significance(P<0.05).(2)In plasma BNP level for diagnosing chronic cor pulmonale,the area under the receiver operating characteristic(ROC) curve was 0.871,the optimal diagnostic cut-off was 95 . 00 pg/mL and the accuracy was 83.5%;the area under ROC curve for diagnosing left cardiac failure was 0.896 ,the optimal di-agnostic cut-off was 310.50 pg/mL and the accuracy was 84.2%. (3) In the optimal cut-off values of chest X-ray,EKG and BNP, their accuracies for the single diagnosis of chronic cor pulmonale were 66.7%,72.7%and 83.5%respectively,which for single di-agnosis of left cardiac failure were 64.3%,70.1%and 84.2%respectively. Conclusion (1)BNP is involved in the pathophysio-logic process of right cardiac insufficiency and left cardiac failure in cor pulmonale and may serve as an indicator of early diagno-sis of cardiac dysfunction.(2)The diagnostic value of clinical suspected diagnosis combined plasma BNP level detection in chronic cor

  8. Study the Function of Leukocyte Adhesion in the COPD and the Chronic Cor Pulmonale%慢性阻塞性肺病、慢性肺原性心脏病患者白细胞粘附功能的研究

    Institute of Scientific and Technical Information of China (English)

    陈宇洁; 彭香; 陆海英; 赵杰; 万晓兵; 雷松; 周东

    2001-01-01

    目的:探讨慢阻肺、肺心病患者白细胞与正常内皮细胞粘附特点。方法:采用流室系统对正常人、慢阻肺、肺心病患者血白细胞与正常内皮细胞粘附特性进行研究。结果:慢阻肺及肺心病患者组血白细胞粘附率较正常组明显增强(P<0.05);肺心病组的白细胞粘附率较慢阻肺组亦有显著性增强(P<0.05)。结论:白细胞粘附作用的增强在慢阻肺、肺心病的发病过程中起了重要作用。%Objective:Study the adhesion characters between the leukocytes and the normal endothelium cells in the COPD and the Cor pulmonale patients.Methods:By flow chamber system,study the adhesion characters between the leukocytes and the normal endothelium cells respectively in normal,COPD and Cor pulmonale patients.Results:Leukocytes adhesion rates are significantly increased in the COPD group and the Cor pulmonale group than the normal one(P<0.05),and leukocyte adhesion rate in the Cor pulmonale group is much higher than the COPD group (P<0.05).Conclusion:Increase of the adhesion between the leukocytes plays an important role in the pathogenesis of COPD and of Cor pulmonale.

  9. 普伐他汀对慢性肺源性心脏病患者右心功能的影响%The Influence of Right Heart Function on Patients with Chronic Cor Pulmonale Treated by Pravastatin

    Institute of Scientific and Technical Information of China (English)

    黄怀焕; 林坚耿

    2014-01-01

    Objective:To explore the influence of right heart function on patients with chronic cor pulmonale treated by pravastatin. Method: 64 patients with chronic cor pulmonale were randomly divided into control group (n=32) and research group (n=32) from Aug 2012 to Dec 2013 treated by conventional therapy and combined with pravastatin respectively. The heart function was compared after treatment between the two groups. Results:The VE,VA,VA/VE, PASP,PEP,RVET,PEP/RVET,right ventricular outflow tract inside diameter, right ventricle diameter and right pulmonary artery diameter in research group were significantly better than those in the control group after treatment (P<0.05). Conclusion:It may improve the right heart function on patient with chronic cor pulmonale treated by conventional therapy and combined with pravastatin.%目的:探讨普伐他汀对慢性肺源性心脏病右心功能的影响。方法:将我院2012年8月至2013年12月收治的64例慢性肺源性心脏病患者随机分为对照组(n=32)和研究组(n=32)分别按常规治疗和联合普伐他汀治疗,比较两组治疗后的心功能。结果:治疗组治疗后VE、VA、VA/VE、PASP、PEP、RVET、PEP/RVET、右室流出道内径、右心室内径、右肺动脉内径均明显优于对照组(P<0.05)。结论:在常规治疗的基础上联合普伐他汀可明显改善慢性肺源性心脏病患者的右心功能。

  10. 美托洛尔联合卡托普利治疗肺源性心脏病的临床分析%Curative Effect of Metoprolol and Captopril in Cor Pulmonale

    Institute of Scientific and Technical Information of China (English)

    程凡花

    2015-01-01

    Objective To analyze the effect of combined captopril with metoprolol in cor pulmonale.Methods From March 2014 to March 2015,we chose 68 patients with cor pulmonale in our hospital,according to the order of admission parity law,which was divided into a control group(n=34) and observation group(n=34). The control group used metoprolol alone,the observation group used metoprolol combination with captopril. the clinical efficacy and side effects with two groups were compared.Results Observation group the total effective rate was 97.06%,significantly higher than 82.35% in the control group(P 0.05,there was no statisticaly significant difference. Conclusion Using captopril combine with metoprolol treat the cor pulmonale has two advantages that is good clinical curative effect and high safety.%目的:分析联合应用美托洛尔及卡托普利对肺源性心脏病的疗效情况。方法2014年3月~2015年3月选择我院68例肺源性心脏病患者,按照入院顺序奇偶法,将其分为对照组(n=34例)及观察组(n=34例)。对照组单纯应用美托洛尔,观察组联合应用美托洛尔及卡托普利,比较两组临床疗效及副反应发生情况。结果观察组总有效率为88.24%,高于对照组67.65%(P0.05,差异无统计学意义。结论联合应用美托洛尔及卡托普利治疗肺源性心脏病,不仅临床疗效好,而且安全性高。

  11. The Effect Research on the Low Molecular Heparin Calcium Treating Cor Pulmonale Combination of Respiratory Failure%低分子肝素钙治疗肺心病合并呼吸衰竭的效果研究

    Institute of Scientific and Technical Information of China (English)

    王佐岩; 李玉华

    2015-01-01

    Objective To study the low molecular heparin calcium treatment effect on cor pulmonale combined of the patients. Methods To study the 38 cases patients on the low molecular heparin calcium treating cor pulmonale combination of respiratory failure,the control group (routine treatment) 19 cases and the study group (low molecular heparin calcium) 19 cases patients. The cases were al chosen from July 2013 to August 2014 according to the different treatment groups.To observe and compare the two groups of curative effect. Results The team PaO2,PaCO2 were improved better than the control group. It was in a high treatment efficiency and obvious difference and the statistical y significant (P<0.05). Conclusion To adopt the low molecular heparin calcium treatment with the patients in cor pulmonale,can obtain good curative effect.%目的:研究低分子肝素钙对肺心病合并呼吸衰竭患者的治疗效果。方法搜集2013年7月~2014年8月我院接收的肺心病合并呼吸衰竭38例患者,根据治疗方法不同进行分组,即对照组(常规治疗)与研究组(低分子肝素钙)各19例。观察并比较两组疗效。结果研究组PaO2、PaCO2改善情况优于对照组,治疗有效率较高,有明显差异,有统计学意义(P<0.05)。结论肺心病合并呼吸衰竭患者进行低分子肝素钙治疗,可取得较好疗效。

  12. 10.4.Cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920074 Influence of atmospheric pressurefluctuation on condition of patients with corpulmonale.LI Jmgzhou (李景周),et al.1st Hosp,Fangshan District,Beijing,102400.Chin J Tuberc& Respir Dis 1991; 14 (4): 231-232.Based on investigation of 632 patients with corpulmonale,we found that there were a closecorresponding relationships of attack,exacerba-

  13. Rescue and Nursing of Acute Exacerbation of Cor Pulmonale Combined with Multiple Organ Failure%肺心病急性加重期合并多脏器衰竭的抢救与护理

    Institute of Scientific and Technical Information of China (English)

    王玉梅

    2015-01-01

    Objective:To investigate the rescue and nursing of acute exacerbation of cor pulmonale combined with multiple organ failure (MOF). Method:40 cases of patients with acute phase of cor pulmonale combined with MOF to develop a set of scientific and strict rescue plan,immediately oxygen,established vein channel and effectived anti infection,corrected heart failure,maintenance of the intake of liquid,correction of electrolyte imbalance and acid-base balance,and should set up special care,effectived nursing intervention.Result:40 cases of acute exacerbation of cor pulmonale combined with MOF,respiratory failure and heart failure after the rescue and treatment actively,a total of 5 patients died (of renal failure in 3 cases, pulmonary encephalopathy in 1 case,of which 1 case of digestive tract hemorrhage),the rescue success rate was 87.5%.Conclusion:Acute exacerbation of cor pulmonale combine with MOF should be early discovery,early diagnosis,early prevention,early infection control,relieve airway spasm,improve ventilation,correction of hypoxia and hypercapnia,correct water and electrolyte balance,improve microcirculation,protect liver and kidney function, improve the body immunity and other comprehensive treatment.%目的:探讨肺心病急性加重期合并多脏器衰竭(MOF)的抢救与护理。方法:对40例肺心病急性期合并MOF的患者制定一套科学严密的抢救方案,立即吸氧,建立有效的静脉通道、抗感染、纠正心力衰竭,维持液体入量、酸碱平衡、纠正电解质紊乱,同时应设专人护理,采取积极有效的护理干预措施。结果:40例肺心病急性加重期合并MOF、呼吸衰竭及心力衰竭的患者,经积极有效的抢救和治疗,共死亡5例(其中肾功能衰竭3例、肺性脑病1例,消化道出血1例),抢救成功率87.5%。结论:肺心病急性加重期合并MOF,应早发现、早诊断、早防治,及早控制感染,解除气道痉挛,改善通气,纠正

  14. Clinical characteristics and treatment for chronic cor pulmonale with arrhythmia.%慢性肺源性心脏病心律失常的临床特点及处理

    Institute of Scientific and Technical Information of China (English)

    武莉莉; 王健

    2011-01-01

    Objective To explore the clinical characteristics and therapeutic measures for treatment of arrhythmia in patients with chronic cor pulmonale. Methods Clinical data of 105 cases of chronic cor pulmonale with arrhythmia were retrospectively reviewed and analyzed. Results Only single type of arrhythmia happened in most of these patients, but two or more types of arrhythmia might simultaneously occur in some of them during early or later stage of the disease. A total of 126 times of attacks including supraventricular arrhythmia in 68.25% ( 86/126 ), ventricular arrhythmias in 14.29% ( 18/126 ) and conduction block in 17.46% ( 22/126 ) were happened in these patients. Right bundle - branch block appeared more frequently, it occupied 9.52% cases of conduction block . Most of these cases were complicated with concurrent infection,anoxia, electrolyte disturbances and congestive heart failure, and these factors were closely concerned with arrhythmogenesis. Conclusion In acute exacerbation stage of patients with cor pulmonale, arrhythmia is frequently originated by impulse, and infection, anoxia, electrolyte disturbances and congestive heart failure are common inducing factors. The key of treatment is active control of primary disease and inducing factors, and anti - arrhythmic drugs are not main measure for treatment of arrhythmia in patients with chronic cor pulmonale.%目的 探讨慢性肺源性心脏病(肺心病)心律失常的特点及处理.方法 对105例肺心病合并心律失常患者临床资料进行回顾性分析.结果 多数出现一种心律失常类型,但也有不少患者同时或先后出现两种及两种以上类型的心律失常,共达126例次.其中室上性心律失常68.25%(86/126)、室性心律失常14.29%(18/126),传导阻滞17.46%(22/126),以右束支传导阻滞多见,占9.52%.大部分合并感染、缺氧、电解质紊乱,心衰程度与心律失常发生率明显相关.结论 肺心病急性加重期心律失常以激动起

  15. 重组人脑利钠肽在慢性肺源性心脏病失代偿期的疗效观察%Curative Effect Observation of Recombinant Human Brain Natriuretic Peptide in Decompensated Chronic Cor Pulmonale

    Institute of Scientific and Technical Information of China (English)

    李翊; 刘爱东; 陈小会

    2015-01-01

    目的 探讨重组人脑利钠肽在慢性肺源性心脏病失代偿期的治疗效果.方法 选择天津市第一医院内科病房的慢性肺源性心脏病失代偿期患者70例患者临床资料进行回顾性分析.结果 试验组总有效率优于对照组(P<0.05),14 d血清脑利钠肽、肺动脉压、左室射血分数均优于对照组(P<0.05).结论 重组人脑利钠肽能改善慢性肺源性心脏病失代偿期症状,临床治疗效果显著.%Objective Study therapeutic effect of recombinant human brain natriuretic peptide in decompensated chronic cor pulmonale. Methods Chronic pulmonary heart disease from in the Department of internal medicine of Tianjin First Hospital ward patients with decompensated 70 patients clinical data were retrospectively analyzed. Results The total effective rate of experimental group was significantly better than the control group,P < 0.05, 14 d of serum brain natriuretic peptide, pulmonary artery pressure, left ventricular ejection fraction was significantly better than the control group (P < 0.05). Conclusion Recombinant human brain natriuretic peptide can obviously improve the chronic cor pulmonale decompensation symptoms.

  16. 慢性肺源性心脏病并发心律失常389例临床分析%A Clinical Study of Arrhythmias in Patients with Cor Pulmonale

    Institute of Scientific and Technical Information of China (English)

    张炜平; 周长钰

    2011-01-01

    目的 探讨慢性肺源性心脏病(以下简称肺心病)心律失常的临床特征及治疗原则.方法 本组患者共389例,全部于入院后48 h内通过24 h心电监护或多次常规12导联心电图检查,及时发现心律失常类型并加以分析.结果 本组肺心病患者合并心律失常率达68.89%(268例),其心律失常类型以窦性心动过速、窦性心律不齐及房性期前收缩为主,严重心律失常如室上性心动过速、室性期前收缩、房室传导阻滞、心房颤动、左右束支传导阻滞等也常出现.心律失常的出现及严重程度与心力衰竭程度、肺部感染、低氧血症、水电解质紊乱等密切相关.结论 肺心病心律失常发生率较高,且与肺心病患者病情严重程度密切相关,而心律失常治疗应通过积极的病因及并发症治疗,使用抗心律失常药物不是最佳办法.%Objective To study the clinical characteristics and therapeutic principles of arrhythmias complicated with cor pulmonale. Methods Patients with cor pulmonale ( n = 389 ) were enrolled. The patients received 24-hour ambulatory or 12-lead electrocardiography ( ECG ) monitoring within 48 hours of enrollment. Arrhythmias were identified and analyzed. Results Cor pulmonale patients were complicated with arrhythmias at a rate of 68.89% ( n = 268 ). The arrhythmias consisted mainly of sinal tachycardia, sinal arrhythmia, and atrial premature contraction. Severe arrhythmias were also identified, such as supraventricular tachycardia,ventricular premature contraction, atrioventricular blockade, atrial fibrillation, and bundle transduction blockade. The occurrence and severity of arrhythmias were closely associated with cardiac failure, pulmonary infection, hypoxia, and water/electrolyte disturbance. Conclusion Core pulmonale is frequently complicated with arrhythmias whilst the severity of arrhythmias is closely associated with the underlying disease. The treatment of arrhythmias focuses on the

  17. Clinical Report of 40 Cases Cor Pulmonale Heart Failure and Arrhythmia in the Treatment of Metacentric Granule%稳心颗粒治疗肺心病心力衰竭并心律失常40例临床回顾

    Institute of Scientific and Technical Information of China (English)

    孟光伟; 杨旺胜; 罗永生; 蔡继婷; 王郑; 张鑫海; 孔吉武

    2015-01-01

    Objective Metacentric particles for treatment of cor pulmonale heart failure and arrhythmia. Methods Our hospital and USES the metacentre grain treatment of 40 patients with cor pulmonale heart failure and arrhythmia as a group, select the same conventional drug treatment of 40 patients with cor pulmonale heart failure and arrhythmia as control group, two groups were retrospectively analyzed clinical effect. Results After treatment, the team improve the cardiac function indexes and clinical total effective rate, compared with the control group was statistically significant (P<0.05). Conclusion Metacentric granule in the treatment of cor pulmonale heart failure and arrhythmia in clinical effect is good, is worth popularization and application.%目的:稳心颗粒治疗肺心病心力衰竭并心律失常的临床效果研究。方法选取我院收治并采用稳心颗粒治疗的肺心病心力衰竭并心律失常患者40例将其作为研究组,选取同期采用常规药物治疗的肺心病心力衰竭并心律失常患者40例作为对照组,回顾性分析两组临床效果。结果治疗后,研究组各项心功能指标改善情况及临床总有效率等,与对照组比较有统计学意义(P<0.05)。结论稳心颗粒治疗肺心病心力衰竭并心律失常的临床效果较好。

  18. The Clinical Value of CT Examination Applied to Cor Pulmonale Pulmonary Hypertension%CT检查应用于肺源性心脏病肺动脉高压的临床价值

    Institute of Scientific and Technical Information of China (English)

    宁欣

    2015-01-01

    Objective:To study the clinical value of the CT plain scan and enhanced scan is applied to cor pulmonale pulmonary hypertension.Method: 40 patients with cor pulmonale in the hospital from November 2012 to November 2013 were selected as the research object, one of the group of 20 patients with radiation chest check the radio-graphic inspection group, another group of 20 cases by chest CT scan and enhanced scan CT inspection group, two groups of patients were checked before and after therapy. before and after treatment the main pulmonary artery, left and right pulmonary artery diameter changes of the two groups were compared.Result:The diameter of the pulmonary artery, left and right pulmonary artery: diagnosis by radiation measurement results compared before and after the treatment lines had significant difference (P<0.01), but lower right pulmonary artery of stem diameter of 15 mm were 12 cases (60%), show the X-ray measurement right pulmonary artery stem diameter for diagnosis of lung pulmonary hypertension was of certain clinical value, but its specificity was poor. CT plain scan and enhanced scan results all lines had significant difference (P<0.01), in the lower right pulmonary artery all stem diameter 15 mm or higher, significantly higher than that of radio-graphic inspection group (P<0.01), and strong specificity.Conclusion:CT examination is applied to the diagnosis of pulmonary hypertension and cor pulmonale therapeutic effect evaluation of clinical value.%目的:研究CT胸部平扫加增强扫描检查应用于肺源性心脏病肺动脉高压的临床价值。方法:选择2012年11月-2013年11月本院诊断为肺源性心脏病住院患者40例作为研究对象,其中放射线检查组20例采用放射线胸部检查,CT检查组20例采用CT胸部平扫加增强扫描检查,两组患者均在治疗前后进行检查。比较两组患者治疗前后主肺动脉,左、右肺动脉直径变化。结果:肺总动脉、左右肺动脉的直

  19. Analysis of Clinical Treatment Effect of Senile Cor Pulmonale in Acute Heart Failure%老年肺心病急性期心力衰竭的临床治疗及效果分析

    Institute of Scientific and Technical Information of China (English)

    李航

    2013-01-01

      目的探讨老年人慢性肺源性心脏病急性期心力衰竭的临床治疗方法及及治疗效果。方法将2008年1月-2012年6月间在我院住院治疗的128例肺心病急性期心力衰竭的病人随机分为两组,对照组64例,常规采用西药抗感染、利尿、扩血管降低心脏负荷等方法;实验组64例,在对照组用药基础上加用中成药制剂参麦注射液,观察两组病例的临床疗效。结果对照组患者,咳嗽、咯痰、胸闷、喘息、心悸等症状减轻或消失,治疗后总有效率90%,随访1年15例复发再次住院;实验组患者,咳嗽、咯痰、胸闷、喘息、心悸等症状明显减轻或消失,有效率97%,同时住院时间缩短,随访1年无复发。结论老年患者肺心病急性期心衰的治疗,中药与西药的联合应用可明显提高患者的治疗效果,降低复发率,值得临床推广应用。%Objective Study of chronic cor pulmonale in acute heart failure in elderly patients of clinical treatment methods and treatment effect. methods Will be in January 2008-June 2012 in our hospital between 128 patients hospitalized with acute phase of cor pulmonale heart failure patients were randomly divided into two groups,control group 64 cases,conventional western medicine anti-infection diuresis expansion of blood vessels are adopted to decrease the cardiac load method;Experimental group of 64 cases in the control group based on medication combined with proprietary Chinese medicine preparations,injection,to observe the clinical ef-ficacy of two groups of cases.Results Control group patients with cough cough up phlegm,chest tightness,heart palpitations and other symptoms ease or disappear,after treatment the total effective rate was 90%,followed up for 1 year 15 cases relapse again in hospital;Experimental group patients cough cough up phlegm,chest tightness,palpitations and other symptoms significantly reduce or disap-pear,the effective rate was

  20. 呋塞米片治疗肺心病急性加重期的临床疗效%Effect of furosemide in treating acute exacerbation of cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    花其彪

    2015-01-01

    Objective To explore the effect of furosemide in treating acute exacerbation of cor pulmonale. Methods A total of 67 patients with acute exacerbation of cor pulmonale were selected in the Chinese Medicine Hospital of Beihai from May 2012 to April 2015,according to the different treatment,they were divided into observation group(36 cases)and control group(31 cases). Control group were given routine treatment,observation group were given furosemide treatment on the basis of control group. Clinical effect,before and after treatment left ventricular ejection fraction(LVEF)and incidence of adverse re-actions between the two groups were compared. Results Clinical effect of observation group was better than that of control group (P 0. 05),LVEF of observa-tion group was higher than that of control group after treatment(P < 0. 05);no one of the two groups occurred serious adverse reactions. Conclusion Furosemide has notable curative effect in the treatment of acute exacerbation of cor pulmonale,can im-prove cardiac function and has less adverse reactions.%目的:探讨呋塞米片治疗肺心病急性加重期的临床疗效。方法选取2012年5月—2015年4月北海市中医医院收治的肺心病急性加重期患者67例,根据治疗方案不同分为观察组(36例)与对照组(31例)。对照组患者予以常规治疗,观察组在对照组基础上予以呋塞米片治疗。观察两组患者临床疗效、治疗前后左心室射血分数(LVEF)及不良反应发生情况。结果观察组患者临床疗效优于对照组,差异有统计学意义( P <0.05);治疗前两组患者 LVEF 比较,差异无统计学意义(P >0.05),治疗后观察组患者 LVEF 高于对照组,差异有统计学意义(P <0.05);两组患者均未发生严重不良反应。结论呋塞米片治疗肺心病急性加重期的临床疗效显著,可改善患者心功能,且不良反应少。

  1. 低分子肝素钙治疗肺心病合并呼吸衰竭患者的临床效果%Low molecular heparin calcium for patients with cor pulmonale complicated with respiratory failure

    Institute of Scientific and Technical Information of China (English)

    李喆; 朱应群; 何龙培; 李玮; 张平

    2016-01-01

    Objective To investigate the clinical effect of low molecular heparin calcium in the treatment of cor pulmonale complicated with respiratory failure.Methods 68 patients with cor pulmonale complicated with respiratory failure were selected from our hospital.The patients were numbered;in accordance with the even number,the patients were divided a control group and an observation group,34 cases for each group.The control group were conventionally treated;in addition,the observation group were treated with low molecular heparin calcium.The clinical curative effect and arterial blood gas changes were compared between these two groups before and after the treatment.Results The total effective rate was 97.1% in the observation group and 76.5% in the control group,with a statistical difference (P<0.05).There were no statistical differences in arterial blood gas and pH between these two groups before the treatment (P>0.05).There were great changes in PaCO2 and PaO2 in both groups and greater in the observation group than in the control group.After the treatment,there were statistical differences in PaCO2 and PaO2 between these two groups (P<0.01).Conclusions Low molecular heparin calcium for patients with cor pulmonale complicated with respiratory failure is significantly effective and can significantly improve the patients' cardiopulmonary function,correct hypoxia,and enhance myocardial contraction force.It is worth being clinically generalized.%目的 探讨低分子肝素钙治疗肺心病并呼吸衰竭的临床效果.方法 选取本院收治的肺心病并呼吸衰竭患者68例,对患者进行编号,按照奇偶数分为对照组和观察组,各34例.对照组常规治疗,观察组在对照组基础上加用低分子肝素钙治疗.比较两组临床疗效及治疗前后动脉血气变化情况.结果 观察组治疗总有效率为97.1%,对照组为76.5%,差异有统计学意义(P<0.05).治疗前,两组动脉血气、pH值比

  2. Correlation between Antioxidant Enzymes Activity and Intraerythrocyte Concentration of Fe, Mg, Zn, Cu in Pulmonary Arterial Hypertension and Cor Pulmonale in Children with Congenital Lung Disease and Cystic Fibrosis

    Directory of Open Access Journals (Sweden)

    Elena M. Vasilyeva, PhD,ScD¹

    2013-03-01

    Full Text Available Significant changes in the levels of the potential prooxidant Cu (increase and the antioxidant Zn (decrease in plasma were revealed in children having bronchopulmonary dysplasia (BPD complicated by pulmonary arterial hypertension (PAH and chronic cor pulmonale (CCP when compared with the control. The Zn / Cu ratio in the blood plasma of patients with BPD, especially in CCP, was found to be lower than in the control group (p<0.001. This could indicate the activation of the prooxidant processes; simultaneously, the total antioxidant status (AOS decreased. No significant increase in the intracellular free (“ionized” (i form of magnesium (iMg was found; in fact, the concentration of iFe in all the patient groups was higher than in the control. An increase in the iCu and iZn levels (nonprotein-bound was observed in the blood cells of the affected children. A significant increase in the glutathione peroxidase activity in the CCP patients may indicate an accumulation of organic peroxides, and partially compensate for the lesser activity of superoxide dismutase (SOD and other antioxidants. The Zn / Cu and iZn/ iCu ratios were reduced in patients with CCP when compared with patients with PD without CCP.

  3. 探讨缬沙坦联合参芎葡萄糖注射液治疗慢性肺源性心脏病的疗效观察%Investigate valsartan combined and men glucose injection treatment the curative effect of chronic cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    宋阳

    2014-01-01

    目的:探讨针对慢性肺源性心脏病患者,选择缬沙坦+参芎葡萄糖注射液完成治疗后的临床效果表现.方法:选取我院2012年06月-2014年06月慢性肺源性心脏病患者170例.通过抽签法完成所有肺源性心脏病患者的随机分组.设为B1组(观察组85例)与B2组(对照组85例).B2组:基础治疗;B1组:基础治疗+缬沙坦+参芎葡萄糖注射液给予临床治疗.对比两组慢性肺源性心脏病患者完成治疗后肺功能改善效果.结果:两组慢性肺源性心脏病患者分别完成治疗后,肺功能均获得改善.B1组肺功能改善程度优于B2组患者明显(P<0.05);在治疗有效率方面,B1组高于B2组明显(P<0.05).结论:针对慢性肺源性心脏病患者,选择缬沙坦+参芎葡萄糖注射液给予临床治疗,在改善患者肺功能指标等方面表现出显著意义.%Objective:Study on patients with chronic cor pulmonale,choose valsartan + and men glucose injection after treatment the clinical ef ect of performance.Methods:Choose our jun 06,2012-2014,170 cases of patients with chronic cor pulmonale.Through the draw method to complete al randomized patients with cor pulmonale.Set to B1 (observation group 85 cases)and B2 group (the control group,85 cases).B2:foundation treatment;B1 group:basic treatment + valsartan,and men and glucose injection for clinical treatment.Compared to two groups of patients with chronic cor pulmonale comG plete lung function improvement after treatment.Result:Two groups of patients with chronic cor pulmonale were done after treatment,al improve lung function.B1 were significantly improved lung function is better than that of B2 group of patients (P<0.05).Conclusion:For patients with chronic cor pulmonale,choose valsartan + men and glucose injection for clinical treatment,in improving the patients showed significant lung function index,etc.

  4. 慢性肺源性心脏病患者急性期血清CKP、LDH和AST测定及临床意义%Determined and clinical significance of serum CPK、LDHand AST in acute period of chronic cor pulmonale patients

    Institute of Scientific and Technical Information of China (English)

    李亲; 周宁

    2001-01-01

    目的:探讨慢性肺源性心脏病(简称肺心病)患者急性期血清磷酸肌酸激酶(CPK)、乳酸脱氢酶(LDH)和天门冬酸氨基转移酶(AST)的变化。方法:检测20例正常对照组、33例急性发作期和20例缓解期肺心病患者血清CPK、LDH和AST,并同时作血气分析。结果:肺心病患者血清CPK、LDH和AST明显高于正常对照组,且急性期高于缓解期(P<0.01);血清CPK、LDH和AST与PaO2呈负相关,与PaCO2呈正相关。结论:血清CKP、LDH和AST测定可反映肺心病病情。%Objective:To study the change of serum creatine phosphokinase (CPK) lactate dehydrogenase (LDH) and aspartic transaminase (AST) in chronic cor pulmonale patients acute peroid.Methods:Serum CPK,LDH and AST were determined in 20cases normal control,33 cases acute attacking peroid and 20 cases remission peroid cor pulmonale patients;at the same time blood gas analysis were made.Results:Serum CPK,LDH and AST in cor pulmonale patients were marked higher than these in normal control group,and these of acute peroid were higher thanremission peroid;serum CPK,LDH and AST were negative correlation with partial pressure of oxygen (PaO2),and positive correlation with partial pressure of carbon dioxide (PaCO2).Conclusion:Determining serum CKP,LDH and AST can reflect cor pulmonale patientss condition.

  5. 肺心病急性加重期 HPAA 与细胞免疫变化的关系%Relationship between HPAA and cellular immunity in acute exacerbation of chronic cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    李艳华; 张聪敏; 石玉珍; 李宝山

    2001-01-01

    To evaluate the relationship between the levels of hormones of the hypothalamic-pituitary-adrenal axis and the change of the cellular immunity in the patients with cor pulmonal during acute exacerbation. The 36 patients with cor pulmonal were examined.The plasma levels of adrenocorticotrophic hormone (ACTH). β-endorphin (β-EP ) and glucocorticoids ( GC ) and the counts of CD+3、CD+4、CD+8 cells and the CD4CD8 ratio in peripheral blood were analysed during acute exacerbation and stable stage. Result showed that in cases during acute exacerbation stage the levels of ACTH. β-EP and GC increased markedly and the counts of CD+3、CD4+、CD+8 cells and the CD4CD8 ratio decreased remarkable (P<0.01). Linear correlation analyses showed that ACTH, β-EP and GC were inversely correlated with CD+3、CD+4 cells counts and the CD4CD8 ratio respectively during acute exacerbation (P<0.01),The study indicated the presence of disorder of neuro-endocrino-immuno-modulation in the cor pulmonale during acute exacerbation . The significantly increased levels of ACTH, β-EP and GC inhibit cellular immunity .%为了探讨肺心病急性加重期患者下丘脑-垂体-肾上腺皮质轴(HPAA)激素水平与细胞免疫变化的关系,本研究同步检测了36例肺心病患者急性加重期及缓解期血浆促肾上腺激素(ACTH)、β-内啡肽(β-EP)、糖皮质激素(GC)及外周血 T 淋巴细胞亚群的变化,并分析它们之间的相互关系。 结果显示肺心病急性加重期ACTH、β-EP、GC均显著升高,CD3、CD4、CD8及CD4/CD8比值显著下降(P<0.01),相关分析显示ACTH、β-EP、GC分别与CD3、CD4、CD4/CD8呈显著负相关。本研究提示肺心病急性加重期机体内发生了神经内分泌免疫调节紊乱,显著升高的ACTH、β-EP、GC对细胞免疫产生抑制作用。

  6. Assessment of Right Ventricular Function by Tissue Doppler Imaging and Right dp/dt Technique in Patients with Cor Pulmonale%组织多普勒成像及右室内压力变化速率评价肺心病患者右室功能

    Institute of Scientific and Technical Information of China (English)

    梁丽萍; 郑艳芬; 邬彩虹

    2012-01-01

    Purpose To discuss the clinical value of right ventricular function in patients with cor pulmonale assessed by TDI and dp/dt measurement. Materials and Methods Subjects were classified as cor pulmonale patient group (90 cases) and normal comparison groups (30 cases) simply having tricuspid regurgitation. Routine echocardiographic examination with color flow continue Doppler wave were performed to measure tricuspid regurgitation and estimate pulmonary arterial pressure as well as right ventricular dp/dt. Tissue Doppler imaging (TDI) technique was used to measure peak flow velocity in early diastolic phase (Em), peak flow velocity in late diastolic phase (Am) and ratio of Em to Am (Em/Am). Peak flow velocity in systolic period (Sm) was also measured. Results Dp/dt, Em, Em/Am and Sm in cor pulmonale patient group were lower than those of normal comparison group (P < 0.01); Am was higher than normal comparison group (P < 0.01). The systole and diastole function of right ventricle in cor pulmonale patients were decreased. There was negative correlation between pulmonary arterial pressure and dp/dt (r =-0.764, P < 0.01). Conclusion TDI with dp/dt measurement is accurate, convenient and repeatable as a new non-invasive diagnostic technique to assess right ventricle function in cor pulmonale patients and provides meaningful clinical information.%目的 探讨应用组织多普勒成像( TDI)技术及右室内压力变化速率(dp/dt)综合评价肺心病患者右室功能的临床价值.资料与方法 90例肺心病患者(肺心病组)和30例单纯三尖瓣反流患者(对照组)常规行超声心动图检查,用血流连续多普勒测量三尖瓣反流,估测肺动脉压(PG)及右心室室内压力变化速率( dp/dt).然后应用组织多普勒成像(TDI)技术从心尖四腔观获得右室侧壁三尖瓣环的运动速度频谱图,测量舒张早期负向E峰峰值速度(Em)、舒张晚期负向A蜂峰值速度(Am)及二者峰值比Em/Am,同时测量收缩期正

  7. 丹红注射液联合环磷腺苷葡胺治疗慢性肺源性心脏病心力衰竭的分析%The Detection of Treatment Chronic Cor Pulmonale Cardiac Failure by Danhong Injection Compared with Meglumine Adenosine Cyclophosphate

    Institute of Scientific and Technical Information of China (English)

    王春红; 李宏伟

    2016-01-01

    Objective To approach result of treatment chronic cor pulmonale cardiac failure by danhong injection com-pared with meglumine adenosine cyclo phosphate. Methods The 50 cases clinical data of chronic cor pulmonale car-diac failure patients in medical team of the Chinese People’s Liberation Army 93253 troops from January 2015 to Jan-uary 2016,control group 25 cases and detection group 25 cases. The BNP changing、LVEF、cardiac output of two groups chronic cor pulmonale cardiac failure patients before treatment and after treatment were detected,the clinical treatment total effective rate of two groups chronic cor pulmonale cardiac failure patients were detected. Results The BNP chang-ing、LVEF、cardiac output of two groups chronic cor pulmonale cardiac failure patients were no difference,P>0.05,the BNP(498.4±52.4)pg/mL and(215.8±24.9)pg/mL、LVEF(39.9±2.0)% and(43.2±2.8)%、cardiac output(6.2±2.1)L/min and (7.9 ±1.9)L/min of control group and detection group after treatment were better than before treatment (1120.3 ± 165.4)pg/ml and(1125.9±166.8)pg/mL、(37.2±1.9)% and(37.1±2.0)%、(5.4±1.9)L/min and(5.5±2.0)L/min,the BNP、LVEF、cardiac output of detection group after treatment were better than control group,the clinical treatment total effec-tive rate 100% of detection group were better than control group 92%,P0.05,对照组和观察组治疗后 BNP 值(498.4±52.4)pg/mL和(215.8±24.9)pg/mL、左心室射血分数(39.9±2.0)%和(43.2±2.8)%、心输出量(6.2±2.1)L/min和(7.9±1.9)L/min均优于治疗前(1120.3±165.4)pg/mL和(1125.9±166.8)pg/mL、(37.2±1.9)%和(37.1±2.0)%、(5.4±1.9)L/min和(5.5±2.0)L/min,观察组治疗后BNP值、左心室射血分数、心输出量均优于对照组,观察组临床治疗总有效率100%均高于对照组92%,P<0.05,差异均有统计学意义。结论丹红注射液联合环磷腺苷葡胺治疗慢性肺源性心脏病心力衰竭患者血流动力学和BNP改善明显,预后良好,值得临床推广应用。

  8. 丹红、硫酸镁注射液联用治疗慢性肺心病急性加重期疗效观察%Observation of curative effect on Danhong Injection and Magnesium Sulfate Injection in the treatment of chronic cor pulmonale in acute exacerbation

    Institute of Scientific and Technical Information of China (English)

    董芳; 杨钦清; 马瑞斌; 柯颖

    2011-01-01

    Objective: To observe the effect of Danhong Injection and Magnesium Sulfate Injection in the treatment of chronic cor pulmonale in acute exacerbation. Methods: 78 patients with chronic cor pulmonale in acute exacerbation of our hospital were randomly divided into treatment group (n=39) and control group (n=39). The control group was treated with routine western medicine, the treatment group was additionally given Danhong Injection combined with Magnesium Sulfate Injection, 2 weeks as a course. The effects and blood gas analysis and pulmonary artery pressure before and after treatment were compared between the two groups. Results: Both groups had obvious effects. Compared with the control group, patients in the treatment group had a better improvement in pulmonary function and blood gas analysis, as well as a more marked decline in pulmonary artery pressure. All these measurements had significant differences between the two groups (P<0.05). Conclusion: There is an obvious therapeutic effect of Danhong Injection and Magnesium Sulfate Injection in the treatment of chronic cor pulmonale in acute exacerbation.%目的:观察丹红和硫酸镁注射液联用对慢性肺心病急性加重期的疗效.方法:选择我院78例慢性肺心病急性加重期患者,将其随机分为治疗组(n=39)和对照组(n=39).两组均给予常规西医综合治疗,治疗组在常规治疗基础上加用丹红和硫酸镁注射液静脉滴注,2周为1个疗程.比较两组患者的疗效及治疗前后血气分析、肺动脉压方面有无差异.结果:两组都有明显疗效,但与对照组比较,治疗组在肺功能及血气结果的改善更加显著,肺动脉压的下降更明显,差异有统计学意义(P<0.05).结论:丹红和硫酸镁注射液联用对治疗慢性肺心病急性加重期有显著疗效.

  9. A Rare Cause for Acute Cor Pulmonale

    Directory of Open Access Journals (Sweden)

    C. Rajasekharan

    2011-06-01

    Full Text Available A number of diseases may cause right atrial mass. Primary cardiac tumors range from 0.002 to 0.25%. Intracardiac manifestation and pulmonary embolism of hepatocellular carcinoma (HCC is a very rare finding and uncommon even at autopsy. Here we describe the case of a 32-year-old Asian man who was referred for shortness of breath lasting for a month, along with unproductive cough. He was a manual laborer with a history of diabetes, alcoholism, and smoking. Clinically he was diagnosed as having pulmonary embolism. Echocardiogram showed a mass in the right atrium. Magnetic resonance imaging showed that he had a large mass in the right atrium extending down into the inferior vena cava. Further evaluation showed that he had chronic liver disease with portal hypertension and was hepatitis B surface antigen-positive, indicating hepatitis B infection. He underwent excision of the mass, and the pathological report showed metastasis of HCC with multiple vascular emboli in the lungs. As this is the second reported case of this kind in the literature, we highlight the need of screening at least 6-monthly all patients with chronic liver disease, hepatitis B and C virus infection for the early detection of HCC.

  10. A rare cause for acute cor pulmonale.

    Science.gov (United States)

    Rajasekharan, C; Ganga, V

    2011-05-01

    A number of diseases may cause right atrial mass. Primary cardiac tumors range from 0.002 to 0.25%. Intracardiac manifestation and pulmonary embolism of hepatocellular carcinoma (HCC) is a very rare finding and uncommon even at autopsy. Here we describe the case of a 32-year-old Asian man who was referred for shortness of breath lasting for a month, along with unproductive cough. He was a manual laborer with a history of diabetes, alcoholism, and smoking. Clinically he was diagnosed as having pulmonary embolism. Echocardiogram showed a mass in the right atrium. Magnetic resonance imaging showed that he had a large mass in the right atrium extending down into the inferior vena cava. Further evaluation showed that he had chronic liver disease with portal hypertension and was hepatitis B surface antigen-positive, indicating hepatitis B infection. He underwent excision of the mass, and the pathological report showed metastasis of HCC with multiple vascular emboli in the lungs. As this is the second reported case of this kind in the literature, we highlight the need of screening at least 6-monthly all patients with chronic liver disease, hepatitis B and C virus infection for the early detection of HCC.

  11. Based on the current situation of chronic cor pulmonale with upper gastrointestinal hemorrhage of governance research%基于当前情况下的慢性肺心病伴随上消化道出血的治护思路研究

    Institute of Scientific and Technical Information of China (English)

    陈世英

    2014-01-01

    Objective:In patients with chronic cor pulmonale with upper gastrointestinal hemorrhage treatment and nursing ideas are briefly analyzed.Methods::In March 2012 - December 2013 to our hospital with chronic cor pulmonale patients with upper gastrointestinal hemorrhage as the research object,a total of 120 cases.60 patients with 120 cases of patients,male and female patients with 60 cases. Of 120 patients after clinical treatment ef ect and the nursing ef ect of comparative analysis,and chronic cor pulmonale with upper gastrointestinal hemorrhage treatment and nursing mode are briefly ana-lyzed.Result:After 8 days of treatment and nursing,120 cases of patients with overal ef ective hemostatic rate of 80%,the ef ect is remarkable.Conclusion:In patients with upper gastrointestinal bleeding belongs to cor pulmonale is a common complication,the disease is serious when wil be a direct threat to the patient's life,so the clinical treatment should be enhanced and way to improve the nursing means, of patients with comprehensive protection,the greatest degree to ensure life safety of patients and rehabilitation.%目的:对慢性肺心病伴随上消化道出血患者的治疗方式以及护理思路进行简要分析.方法:选择2012年3月-2013年12月到我院就诊的慢性肺心病伴随上消化道出血的患者为研究调查对象,共计120例.120例患者中,男性患者60例,女性患者60例.对120例患者临床治疗效果以及治疗后的护理效果进行对比分析,从而对慢性肺心病伴随上消化道出血的治疗方式以及护理方式进行简要分析.结果:经过8天的治疗及护理,120例患者总体有效止血率达到80%,效果显著.结论:上消化道出血属于肺心病患者中比较常见的一种并发症,病情十分严重时将直接威胁到患者的生命,所以必须通过加强临床治疗手段以及改善护理手段的方式,对患者进行全方位治护,最大程度保证患者的生命安全以及康复程度.

  12. 硝苯地平对肺源性心脏病急性加重期患者血浆内皮素变化的影响%Effects of nifedipine on plasma endothelin in cor pulmonale with acute exacerbation

    Institute of Scientific and Technical Information of China (English)

    熊洁

    2008-01-01

    目的 探讨硝苯地平对肺源性心脏病(肺心病)急性加重期患者血浆内皮素(ET)、一氧化氮(NO)的影响及治疗意义.方法 将使用硝苯地平前、后患者血浆ET、NO含量分别与常规治疗前后患者及健康人作比较.结果 肺心病患者ET增多,NO减少,使用硝苯地平后,ET含量回降幅度增大,NO含量增多,升幅显著大于常规治疗组.结论 硝苯地平可促进肺心病急性加重期血浆ET下降,促进NO产生,有助于减轻肺动脉高压.%Objective To determine the effect of nifedipine on cor pulmonale with acute exacerbation.Methods One hundred patients were included in the study and divided randomly into two groups:control group and TMP group.All patients were treated conventionally,and TMP group patients were injected 400 mg TMP everyday.ET and NO in blood plasma were measured in all patients before and after treatment. Results Compared with the healthy people,a significant elevation of ET,a vasoconstrictive factor and decrease of NO,a vasodilative facter,were found during occurrence of the disease. After being administered with TMP,the level of ET was lower than that in control group,and the level of NO was higher than that in control group.Conclusion The administration of TMP in cor pulmonale with acute exacerbation is helpful in lowering pulmonary arterial pressure.

  13. Clinical Study of Wenxin Granule in Treating Chronic Cor Pulmonale Complicated by Premature Ventricular Contractions%稳心颗粒治疗慢性肺源性心脏病合并频发室性期前收缩的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    王永; 吕高荣

    2012-01-01

    目的 观察稳心颗粒治疗慢性肺源性心脏病(肺心病)合并频发室性期前收缩的临床疗效及不良反应.方法 将130例肺心病合并室性期前收缩患者随机分为治疗组和对照组,每组65例,均给予常规综合治疗,治疗组加用稳心颗粒,1包/次,3次/d,温开水冲服,4周为1个疗程.结果 治疗后治疗组室性期前收缩次数明显下降,心悸、胸闷、气短等临床症状均较对照组好转,且差异有统计学意义(均P<0.01),治疗组临床疗效及心电图的疗效分别为92.3%(60/65)、93.8%(61/65),对照组分别为76.9%(50/65)、75.4%(49/65),两组比较差异有统计学意义(P<0.05).治疗组服药期间未发现与稳心颗粒相关的不良反应.结论 稳心颗粒治疗肺心病合并室性期前收缩具有疗效显著、安全可靠、见效快、无不良反应等诸多优点,值得临床推广应用.%Objective To observe the efficacy and adverse reaction of wenxin granule in the treatment of chronic cor pulmonale combined with premature ventricular contractions ( PVC ). Methods 130 cases of cor pulmonale with PVC were randomly divided into two groups: therapy group and control group both receiving the routine comprehensive treatment. Besides that, the therapy group was administrated additional wenxin granule, each time a packet, 3 times a day, warm boiled water, 4 weeks for a course of treatment. Results After treatment, the PVC times had an obvious decrease in the therapy group and palpitations , chest tightness, shortness of breath and other symptoms all had a better improvement than those in the controls, and the differences were statistically significant ( P < 0. 01 ). Effective rates of clinical treatment and ECG treatment were 92. 3% ( 60/65 ), 93. 8% ( 61/65 ) in the therapy group, and they were 76. 9% ( 50/65 ) and 75. 4% ( 49/65 ) respectively in the control group, the difference was statistically significant ( P <0. 05 ). No adverse reactions related to wenxin granule

  14. 无创通气技术在肺心病合并Ⅱ型呼吸衰竭治疗中的应用价值%clinical application of noninvasive ventilation in the treatment of cor pulmonale combined with type 2 respiratory failure

    Institute of Scientific and Technical Information of China (English)

    巩晓峰; 吕建斌

    2013-01-01

    目的 探讨无创正压通气技术(BiPAP)在肺心病合并Ⅱ型呼吸衰竭治疗中的应用价值.方法 选取慢性肺心病合并Ⅱ型呼吸衰竭患者40例,随机分为对照组和观察组,每组20例.对照组给予低流量吸氧、常规抗感染、解痉平喘、纠正水电解质紊乱等基础治疗,观察组在此基础上加用无创正压通气治疗.观察2组患者治疗前和治疗后24 h的临床表现、动脉血气变化、生命体征和不良反应.结果 治疗后24 h,2组RR、HR均有所降低,差异有统计学意义(P<0.01);治疗后,观察组Sa(O2)显著升高,与对照组比较差异有统计学意义(P<0.01); Pa(CO2)和Pa(O2)明显下降,2组比较差异有统计学意义(P<0.05);观察组pH值与对照组相比,差异有统计学意义(P<0.05).结论 BiPAP可有效改善肺心病合并Ⅱ型呼吸衰竭患者的临床症状,减轻心脏负荷,且不良反应较少,值得临床推广应用.%Objective To observe noninvasive positive pressure ventilation technology (BiPAP) in the treatment of cor pulmonale combined with type 2 respiratory failure.Methods Forty patients with chronic cor pulmonale combined with type 2 respiratory failure were selected and randomly divided into control group (n =20) and observation group (n =20).The control group received routine treatment of low flow oxygen and routine anti-infection to relieve spasmolysis and asthma and correct water and electrolyte disorder.The observation group,on the basis of the routine treatment of the control group,received noninvasive positive pressure ventilation.Clinical manifestations,arterial blood gas changes and adverse reactions of the two groups before and 24 hours after treatment were observed.Results Twenty-four hours after treatment,RR and HR of the two groups were reduced and the differences were statistically significant (P < 0.01).Sa(O2) of the observation group increased significantly after treatment.The difference of the two groups was

  15. 低分子肝素联合酚妥拉明治疗肺心病顽固性心衰的疗效观察%Observation on clinical effects of low molecular heparin combined with phentolamine in treatment of cor pulmonale with refractory heart failure

    Institute of Scientific and Technical Information of China (English)

    张育红

    2013-01-01

    目的 观察低分子肝素联合酚妥拉明治疗肺心病顽固性心衰的疗效.方法 选择我院2010年5月至2012年11月收治的70例肺心病顽固性心衰患者,随机分为观察组和对照组各35例,对照组常规综合治疗,观察组在常规综合治疗基础上加用低分子肝素联合酚妥拉明治疗,比较分析两组疗效.结果 观察组治疗总有效率为94.28%,对照组治疗总有效率为77.14%,观察组疗效显著优于对照组(P<0.05).治疗前两组患者的全血比粘度、红细胞压积、血浆比粘度和血红蛋白都没有统计学差异(P>0.05),治疗后观察组患者的上述指标都显著优于对照组(P<0.05).结论 低分子肝素联合酚妥拉明治疗肺心病顽固性心衰疗效确切、安全,值得临床推广使用.%Objective To observe the clinical effects of low molecular heparin combined with phentolamine in treatment of cor pulmonale with refractory heart failure.Methods We analyzed the clinical effects of the low molecular heparin combined with phentolamine to the routine complex treatment (observation group,n=35) or the routine complex treatment (control group,n=35) for treatment of 70 patients with cor pulmonale with refractory heart failure in our hospital from May 2010 to November 2012.Results After treatment,whole blood contrast was (7.09 ± 1.25),hematocrit was (0.541 ± 0.114),blood plasma viscosity was (1.62 ± 0.07),hemoglobin was (121.31 ± 25.22) g/L,and clinical effect rate was 94.28% in the observation group.Whole blood contrast was (8.87 ± 1.13),hematocrit was (0.592 ± 0.125),blood plasma viscosity was (1.83 ± 0.11),hemoglobin was (136.36:±:36.63) g/L,and clinical effect rate was 77.14% in the control group.The clinical effects and blood rheology in the observation group were significantly better than those in the control group.Conclusion The low molecular heparin combined with phentolamine in treatment of cor pulmonale with refractory heart failure has

  16. Application of reduced glutathione in the elderly with hepatic dysfunction induced by acute exacerbation of chronic cor pulmonale%还原型谷胱甘肽在老年慢性肺心病急性加重期肝损害患者中的应用

    Institute of Scientific and Technical Information of China (English)

    雷澍; 吴艳春; 王灵聪; 吴建浓; 郭小文

    2005-01-01

    目的探讨还原型谷胱甘肽(GSH)对老年慢性肺心病患者急性加重期肝损害的作用.方法 66例60岁以上老年慢性肺心病急性加重期肝损害患者随机分为两组.所有入选患者采用慢性肺心病急性加重期常规方案治疗.对照组(n=31)护肝采用静脉滴注肌苷1.0g,维生素C 2.0g和门冬氨酸钾镁20mL,1次/d,连用2周.治疗组(n=35)护肝采用GSH1.2g经静脉输入,2次/d,连用2周.同时监测治疗前后肝功能指标血丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、总胆汁酸(TBA)、白蛋白(ALB)、凝血酶原时间(PT)及child-push评分并进行对照比较.结果治疗组较对照组在慢性肺心病急性加重期肝损害的肝功能复常方面显示更为良好的治疗效应,ALT,AST,TBIL,TBA和child-push评分改善明显好于对照组(P均<0.01);治疗组30d内急性肾功能衰竭的发生率低于对照组(P<0.05);PT,ALB,出院时的死亡率和30d内多脏器功能障碍综合征(MODS)发生率两组比较无显著性差异(P均>0.05).结论 GSH治疗老年慢性肺心病急性加重期患者肝损害是有效的和安全的.在慢性肺心病常规方案治疗的基础上应用GSH对老年慢性肺心病急性加重期患者肝损害具有一定的改善作用,其疗效优于常规护肝治疗.%OBJECTIVE To investigate the effect of reduced glutathione (GSH) on the hepatic dysfunction induced by acute exacerbation of chronic cor pulmonale in the elderly. METHOD A total of 66 patients aged 60 years or older with hepatic dysfunction following acute exacerbation of chronic cor pulmonale were randomly divided into 2 groups. All patients received conventional basic therapy for acute exacerbation of chronic cor pulmonale. The control group (n = 31 ) received intravenous inosine 1.0g, vitamin C 2.0g, and kali magnesii aspartatis 20mL once daily for 2 weeks. The GSH group (n = 35) received intravenous GSH 1.2g ql2h for 2weeks. The protective effect against

  17. 28 CFR 79.61 - Definitions.

    Science.gov (United States)

    2010-07-01

    ...) Cor pulmonale means heart disease, including hypertrophy of the right ventricle, due to pulmonary..., pulmonary fibrosis, cor pulmonale related to fibrosis of the lung, silicosis, and pneumoconiosis....

  18. 28 CFR 79.51 - Definitions.

    Science.gov (United States)

    2010-07-01

    ...) Cor pulmonale means heart disease, including hypertrophy of the right ventricle, due to pulmonary... fibrosis, cor pulmonale related to fibrosis of the lung, silicosis, and pneumoconiosis. (k)...

  19. M2受体抗体在肺源性心脏病发病中大鼠心脏结构影响的实验研究%Effects of muscarinic receptor M2 antibody on heart structure in rats with cor pulmonale

    Institute of Scientific and Technical Information of China (English)

    刘学军; 王小慧; 钱力; 吴博威; 刘慧荣

    2012-01-01

    Objective To investigate the effects of muscarinic receptor M2 antibody on the heart structural in established rat models of cor pulmonale. Methods A total of 60 rats were randomly allocated into 5 groups (n=12 each): hypoxia group, cyclosporine A group, nicardipine group, control group and active immunized group, respectively. In these groups, the level of serum muscarinic receptor M2 antibody was measured, and the changes in heart structure were observed with light and electronic microscopes for computation of relevant parameters. Results The positive rate of muscarinic receptor M2 antibody was 67% and 100%, respectively, in hypoxia and active immunized groups, with statistical difference (P0.05). There was a remarkable alteration in heart structure in both hypoxia and active immunized groups as compared control group. No structural difference was revealed in cyclosporine A group as compared with control group (P>0.05). Conclusion Muscarinic receptor M2 antibody plays a pivotal role in the pathological change of heart structure.%目的 通过建立肺源性心脏病大鼠模型观察M2受体抗体对心脏结构的影响.方法 60只wistar大鼠随机分为5组(每组12只):单纯缺氧组、环孢素A组、尼卡地平组、对照组、主动免疫组,测定各组大鼠血清中M2受体抗体的含量,光镜及电镜下观察各组大鼠心脏结构改变并计算相关指标.结果 M2受体抗体在单纯缺氧组为67%,主动免疫组为100%,与对照组(阳性率为8%)比较差异均有统计学意义(P0.05);与对照组比较,单纯缺氧组及主动免疫组心脏结构有明显变化,环孢索A组与对照组比较差异无统计学意义(P>0.05).结论M2受体抗体在引起心脏结构病理改变的过程中具有重要作用.

  20. Rehabilitation effect of nocturnal noninvasive positive pressure ventilation on respiratory failure in patients with stable chronic cor pulmonale at high altitude area%夜间无创正压通气对高原地区肺心病缓解期慢性呼吸衰竭患者的康复效应

    Institute of Scientific and Technical Information of China (English)

    杨生岳; 冯恩志; 沈君礼; 张瑛; 赵丽红; 吴雪梅; 张冬天

    2005-01-01

    min步行距离:治疗组治疗后明显高于治疗前和对照组治疗后(P<0.05~0.01),动脉血二氧化碳分压:治疗组治疗后明显低于治疗前和对照组治疗后(P<0.01).结论:夜间无创正压通气治疗能显著改善高原地区肺心病缓解期慢性呼吸衰竭患者的动脉血气和肺功能,增强呼吸肌力量.%BACKGROUND: Medicine treatment of chronic respiratory failure achieved little effect. Interfering chronic respiratory failure of chronic cor pulmonale with noninvasive positive pressure ventilation (NIPPV) may be an effective measure to eliminate symptom and physical sign of patients.OBJECTIVE: To investigate the effect of nocturnal noninvasive positive pressure ventilation (NIPPV) on respiratory muscle function, pulmonary function of chronic respiratory failure patients with stable chronic cor pulmonale at high altitude area (HACCP).DESIGN: A completely randomized grouping design and randomized control trial.SETTING: Center of Respiratory Medicine, the 4th Hospital of Lanzhou Military Area Command of Chinese PLA.PARTICIPANTS: Totally 60 HACCP patients with chronic respiratory failure in stable stage, 38 male and 22 female, were admitted to Department of Respiratory Disease, the 4th hospital of Chinese PLA from October 2002 to November 2004. All cases, after informed consent was obtained,were randomly divided into two groups, including treatment group and control group with 30 cases in each group.METHODS: [1] Treatment group: Fitted with ventilator with pressure support ventilation (PSV) mode or positive end-expiratory pressure (PEEP)mode from 22:00 to next 7:00 every night. Before and after 5 weeks therapeutics, pulmonary function, arterial blood gas, respiratory muscle function and 6-minute walking distance (6MWD) were measured. Control group:Those were either assessed in inpatient objects stabled at least 1 week as control group before discharged and 5 weeks thereafter. [2] 6-minute walking distance (6MWD) test: Patients

  1. Effect of phentolamine and diltiazem on pulmonary artery hypertension in exacerbations of chronic obstructive pulmonary disease patients with chronic cor pulmonale%酚妥拉明联合地尔硫(卓)对慢性肺心病急性加重期肺动脉高压的疗效观察

    Institute of Scientific and Technical Information of China (English)

    付松泉; 王莉; 刘圳奋; 路婷; 王丽红

    2011-01-01

    Objective To evaluate the effects of phentolamine and diltiazem on pulmonary artery hypertension in exacerbations of patients with chronic cor pulmonale caused by chronic obstructive pulmonary disease(COPD). Methods One hundred and twenty-five patients with COPD compicated with cor pulmonale were randomly divided into routine group ( n = 35), phentolamine group( n = 30), diltiazem group( n = 30) and phentolamine+ diltiazem group( n = 30). Four groups were given routine treatment and phentolamine group was given phentolamine(10 mg) intravenous infusion by micro pump(0.4- 0.6 mg/h), diltiazem group was given oral diltiazem supplement (30 mg, three times a day),phentolamine+ diltiazem group was given phentolamine (10 mg) intravenous infusion by micro pump and oral diltiazem supplement (30 mg, three times a day). Change of brain natriuretic peptide(BNP) and mean artery pulmonary artery pressure(mPAP) after 14 days were measured. Results In treatment groups,BNP and mean pulmonary artery pressure decreased significantly after 14 days of treatment compared with those before treatment in the same group and routine group (all P <0.05). mPAP in routine group(55.2±6.5)mmHg vs (48.6±8. 2) mmHg( P <0. 05),BNP (602.9± 96. 6) pg/L vs (416.2 ± 43.7) pg/L( P <0.05) ; mPAP in phentolamine group(57. 3 ± 6.8) mmHg vs (42.1±9.6) mmHg( P <0. 05),BNP(628.2±89.1) pg/L vs (356.1±37.9) pg/L( P <0.01);mPAP in diltiazem group(56.2±6.1) mmHg vs (43.4±8. 9) mmHg( P <0.05) ,BNP(612. 7±87. 4) pg/L vs (382. 9±37.5) pg/L( P < 0.01) ; mPAP in phentolamine+diltiazem group(58.3±6.7) mmHg vs (30.5±7.7) mmHg( P<0.01) ,BNP(644. 6± 98.3) pg/L vs (286.5±33.4) pg/L( P <0.01). Further extremely significant downregulation of BNP expression and mean pulmonary artery pressure were observed in phentolamine and diltiazem group after the following 14 days'treatment. Conclusion Phentolamine and diltiazem can adjust the synthesis and secretion of BNP,and the treatment can

  2. Clinical observations on treatment with integrated traditional Chinese medicine and western medicine for episodic stage of cor pulmonale%中西医结合治疗肺源性心脏病急性发作期的临床观察

    Institute of Scientific and Technical Information of China (English)

    李俊成; 田银海; 张辉; 黄爱贞

    2001-01-01

    目的:探讨中西医结合疗法对 肺源性心脏病(肺心病)的疗效。方法:86例肺心病急性发作期患者随机分成2组,43例对照组患者采用吸O2、抗生素、解痉平喘、强心、利尿、纠正电解质紊乱和酸碱失衡等治疗。治疗组43例患 者 给以口服慢阻通气丸、抗咳喘丸,同时静滴清开灵注射液、丹参注射液、维脑络通,必要时 吸O2,注意纠正酸碱失衡和电解质紊乱。2组疗程均14日。结果:治疗组总有效率为88.3 7%,显著高于对照组58.14%(χ2=10.50,P<0.01)。治疗组治疗后血气分析 动脉 氧分压(PaO2)、pH值升高,二氧化碳分压(PaCO2)下降;肺功能中肺活量(VC),第1秒用力呼气容积(FEV1)及用力 肺活量(FVC)增加,较对照组均有显著改善(P均<0.05)。结论:中西医结合疗法具有改善血气指标和肺功能,提高临床疗效的作用。%Objective:To investigate the curative effects of integrated traditional Chinese medicine and western medicine on cor pulmonale( CP).Methods:Eightysix cases with CP who were in episodic sta ge were randomly divided into two groups (43 cases for each group).The control group was treated with symptomatic therap ies,including inhaling oxygen,antiinfective,inotropic,diuretic,relie ving bronchial spasm and wheeze,correcting electrolyte disorder and acid base imbalance and so on,otherwise the treated group treated with Manzu Tongq i pill(MZTQP,慢阻通气丸) and Ka ngkechuan pill(抗咳喘丸) taken orally meanwhile Qingkailing inject ion(清开灵注射液),salvia milt iorrhiza injecton,and venoruton infused intravenously once a day .If necessary inhaling oxygen and correcting electrolyte disorder and acidbase imbalance had been used.Fourteen days as a therapeuti c course to both groups.Results:The total effective rate(88.37%) in treated group was si gnificantly higher than that(58.14%) in control group(χ2=10.50,P<0. 01). Furthermore in treated group

  3. Epideioloical data of chronic cor pulmonale in patients with chronic obstructive pulmonary disease in Qinghai Plateau%青海高原慢性阻塞性肺疾病所致慢性肺源性心脏病流行病学调查

    Institute of Scientific and Technical Information of China (English)

    高芬; 杜发茂; 拉周; 杨彩铃

    2011-01-01

    Objective To investigate the prevalence of chronic cor pulmonale (CCP) with chronic obstructive pulmonary disease (COPD) in Qinghai Plateau. Methods Using the questionaire of high risk group COPD the survey was performed to the 23 725 population aged over 15 years by random disproportional cluster sampling in Qinghai Plateau. The COPD was diagnosed by spirometry. The CCP were confirmed according to the national criteria (1980) by chest radiography and electrocardiography.Results There were 62 CCP patients in 159 cases with COPD, among them 45 cases were male and 17cases were female. The prevalence of CCP accounted for 0.26% and for 38. 99% of the patients with COPD. Distribution of CCP in Qinghai Plateau was that CCP prevalence of males was higher than that of the female (accounted for 72. 58%). It increased with years of age and went up topmost in 60~69 years old, The prevalence of CCP of farmers was highest in the urban dwellers, half-herdsmen, cadres and pastoralists. There was the characteristical that it cut down to follow altitude upgrade. The incidence of CCP in altitude 1 920-2 500 m area was 0.37%, that account for 82. 26% of the all CCP patients of Qinghai Plateau. Conclusions The prevalence of CCP in patients with COPD was low in Qinghai Plateau.%目的 了解青海高原慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)所致慢性肺源性心脏病的患病情况.方法 采用分层、不等比、整群随机抽样方法对青海省≥15岁共计23 725人,按照"慢性阻塞性肺疾病,肺心病高危人群基线调查表"进行COPD流行病学调查.对肺功能检查筛选出的COPD患者进行X线胸片、12导联心电图检查.慢性肺源性心脏病诊断采用1980年全国慢性肺源性心脏病会议诊断标准.结果 在检出159例COPD患者中,共诊断慢性肺源性心脏病62例(男性45例,女性17例),占COPD 38.99%(62/159),占调查人群的0.26%(62/24 196).青海地区慢性肺源性心脏病分布特点是:男

  4. Study on change of serum 1,25-(OH)2D3 and on the reasons of that in patients with advanced cor pulmonale%肺心病急性加重期患者1,25-(OH)2D3改变及其原因的研究

    Institute of Scientific and Technical Information of China (English)

    王方剑; 王春丽; 曹洁; 金镇勋; 黄强; 贺红

    2004-01-01

    Objective: To study the change of serum 1,25 - (OH) 2 D3 and the masons for the change of serum 1,25 - (OH)2D3 in patients with advanced cor pulmonale. Methods:The serum 1,25 - (OH)2D3, 25 - (OH)D3, parathormone ( PTH ) and the serum calcium, phosphorus and magnesium ( Sca, SP, SMg) were measured in 48cases with the disease. Results: Compared with the control group, the serum 1,25 -(OH)2D3 ,25 - (OH)D3, PTH and the Sca,SMg were lower significantly(P <0.01 ) ,SP was not significantly lower. In the patient group,the 1,25- (OH) 2 D3 of those whose 25 - (OH) D3 and PTH were lower than their separate mean values was decreased significantly ( P < 0.05,P < 0.01 ), compared with the 1,25 - (OH) 2 D3 of those whose 25 - (OH) D3 and PTH were higher than their separate mean values despectively. Conclusions: 1,25 - (OH)2D3 were decreased obviously in the patients. Descreased 25 - (OH) D3 and PTH were the reasons of the decreased 1,25 - (OH)2 D3. It was necessary for the patients to be supplied with VitD3 properly.%目的探讨肺心病急性加重期1,25-(0H)2D3改变及其改变的原因.方法测定了48例患者血1,25-(OH)2D3、25-(OH)D3、甲状旁腺素(PTH)和血钙磷镁(SCa、SP、SMg).结果与对照组相比,病人组l,25-(OH)2D3、25-(OH)D3、PTH、SCa和SMg显著降低(P均<0.01).25-(OH)D3低于均值组的1,25-(OH)2D3值显著低于25-(OH)D3高于均值组者(P<0.05);PTH低于均值组的1,25-(OH)2D3值显著低于PTH高于均值组者(P<0.01).结论肺心病急性加重期时1,25-(OH)2D3显著降低;25-(OH)D3和PTH的降低是1,25-(OH)2D3降低的原因.应予该病患者适量补充药物性维生素D.

  5. Chronic obstructive pulmonary disease

    Science.gov (United States)

    ... and oxygen therapy Right-sided heart failure or cor pulmonale (heart swelling and heart failure due to chronic ... PA: Elsevier Saunders; 2016:chap 44. Read More Cor pulmonale Dilated cardiomyopathy Heart failure - overview Lung disease Patient ...

  6. Fetal cor triatriatum dexter

    DEFF Research Database (Denmark)

    Maroun, Lisa Leth; Graem, Niels; Skibsted, Lillian

    2008-01-01

    Two early-2nd-trimester fetuses were aborted as a result of nuchal edema and suspected severe heart malformation. At autopsy one fetus demonstrated nuchal edema, mild hydronephrosis, and cor triatriatum dexter associated with ventricular septal defect and tubular hypoplasia of the aortic arch....... The other fetus demonstrated severe nuchal edema, and cor triatriatum dexter was the only malformation. Cor triatriatum dexter is a rare cardiac malformation characterized by division of the right atrium into 2 compartments by a usually fenestrated membrane representing remnants of the right valve...... of the embryonic sinus venosus. This malformation has been diagnosed in adults and children by echocardiography, surgery, or autopsy but has not previously been published in fetuses....

  7. Cor pulmona le

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920650 Erythrocyte membrane band 3protein and HCO3-/CL- exchange functionin cor pulmonle patients. YANG Xiaojing(杨晓静), et al. Respir Centre, Xinqiao Hosp,3rd Milit Med Univ, Chongqing, 630037. NatlMed J China 1992; 72(5)277-279. The changes of erythrocyte membrane band 3

  8. Anesthesia and cor triatriatum

    Directory of Open Access Journals (Sweden)

    Federica Scavonetto

    2014-01-01

    Full Text Available Aims and Objectives: Cor triatriatum sinistrum (CTS and cor triatriatum dextrum (CTD are rare congenital anomalies characterized by the presence of a perforated septum which divides the respective atrium into a proximal and distal chamber. This report reviews the perioperative course of patients with uncorrected cor triatriatum (CT undergoing procedures requiring anesthesia. In addition, we performed a literature search that examines the experience of others regarding the peri-operative course of patients with CT. Materials and Methods: A computerized search of a medical record database was conducted to identify patients with a clinical diagnosis of uncorrected CTD and CTS undergoing surgical procedures. Descriptive statistics were used. Results: We identified 12 adult patients with asymptomatic CTS (n = 7 and CTD (n = 5 who underwent 23 anesthetics. There were no perioperative complications which could be attributed directly to the anatomy of CT. Conclusions: Our observation and review of the literature suggest that patients with asymptomatic CT typically tolerate anesthesia and surgical procedures well.

  9. [Cor pulmonale and pulmonary hypertension. Update after the world conference in Nice].

    Science.gov (United States)

    Rosenkranz, S

    2014-02-01

    Pulmonary hypertension (PH) is a common phenomenon which may occur as a consequence of various diseases (e.g. heart failure, chronic lung diseases and pulmonary embolism), as a distinct disease of the small pulmonary arterioles or a combination of both. Independent from the origin, PH has an important impact on patient symptoms and prognosis. Establishment of an exact diagnosis and classification as well as an understanding of the hemodynamic interrelationships provide the basis for often challenging treatment decisions. Recently, the fifth World Symposium on PH took place in Nice, France, where important standards and definitions were specified. The most relevant results including the rating of novel treatment options are summarized in this article.

  10. Sleep-related breathing disorders in patients with schistosomal cor-pulmonale

    Directory of Open Access Journals (Sweden)

    Yehia Khalil

    2012-07-01

    Conclusion: SRBD are highly prevalent in patients with schistosomal pulmonary hypertension (PH. Also, the SA severity was correlated with more advanced PH and more severe cardiovascular impairment. Therefore in the evaluation of patients with schistosomal PH, polysomnography or an ambulatory cardiorespiratory sleep study seems justified to identify potentially treatable SRBD that may additionally challenge the already compromised cardiovascular system in these patients.

  11. Clinical usefulness of thallium-201 myocardial scintigraphy for the diagnosis of chronic cor pulmonale

    Energy Technology Data Exchange (ETDEWEB)

    Hirayama, Jiro

    1987-06-01

    In order to evaluate right ventricular overloading(RVO) and hypertrophy, thallium-201 myocardial scintigraphy applying a new quantitative method was performed on 17 patients with chronic respiratory diseases, 13 autopsy cases and 30 normal subjects. Thallium-201 uptake ratio of left and right ventricular myocardium to the administered dose (LT, RT) were measured scintigraphically, and RT and LT/RT ratio were compared with pulmonary hemodynamic findings and with heart weight measured at autopsy. Mean pulmonary arterial pressure (MPAP) in 17 patients was significantly correlated both with RT (r = 0.78, p < 0.001) and with LT/RT ratio (r = -0.87, p < 0.001). Based on the results of investigations on 30 normal subjects, these patients could be divided into two groups as follows : RVO group (RT greater than or equal to 1.1 and/or LT/RT less than or equal to 2.7) and non-RVO group (RT < 1.1 and LT/RT > 2.7). The patients in the RVO group showed a significantly higher MPAP than those in the non-RVO group (p < 0.01). The efficiency of this method for the diagnosis of pulmonary hypertension (MPAP greater than or equal to 20 mmHg) was eighty-eight percent. In addition, there were significant correlations between RT and the weight of right cardiac mass (r = 0.97, p < 0.001) as well as between LT/RT ratio and the ratio of the weight of left to right cardiac mass (r = 0.94, p < 0.001) in 13 autopsy cases. Thallium-201 myocardial scintigraphy using this quantitative method may be useful for the estimation of right ventricular overloading and hypertrophy in chronic respiratory diseases.

  12. [Cor pulmonale-PHT secondary to crest syndrome. Treatment with slow continuous ultrafiltration].

    Science.gov (United States)

    Fernández Aguirre, C; Daga Ruiz, D; Velasco Garrido, J L; Cota Delgado, F; Hidalgo Sanjuán, M V; Salazar Ramírez, C

    2010-12-01

    Pulmonary hypertension is a severe disease with complex treatment based on general measurements, anticoagulation and use of specific vasodilator drugs. Right heart failure initiated in final stages of the disease is treated with diuretics. We present the case of slow continuous ultrafilitration as treatment in right heart failure secondary to pulmonary hypertension associated to collagen disease refractory to diuretic treatment.

  13. Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation

    Energy Technology Data Exchange (ETDEWEB)

    Sandoval, J.; Salas, J.; Martinez-Guerra, M.L.; Gomez, A.; Martinez, C.; Portales, A.; Palomar, A.; Villegas, M.; Barrios, R. (Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico City (Mexico))

    1993-01-01

    We describe the clinical, radiologic, functional, and pulmonary hemodynamic characteristics of a group of 30 nonsmoking patients with a lung disease that may be related to intense, long-standing indoor wood-smoke exposure. The endoscopic and some of the pathologic findings are also presented. Intense and prolonged wood-smoke inhalation may produce a chronic pulmonary disease that is similar in many aspects to other forms of inorganic dust-exposure interstitial lung disease. It affects mostly country women in their 60s, and severe dyspnea and cough are the outstanding complaints. The chest roentgenograms show a diffuse, bilateral, reticulonodular pattern, combined with normalized or hyperinflated lungs, as well as indirect signs of pulmonary arterial hypertension (PAH). On the pulmonary function test the patients show a mixed restrictive-obstructive pattern with severe hypoxemia and variable degrees of hypercapnia. Endoscopic findings are those of acute and chronic bronchitis and intense anthracotic staining of the airways appears to be quite characteristic. Fibrous and inflammatory focal thickening of the alveolar septa as well as diffuse parenchymal anthracotic deposits are the most prominent pathologic findings, although inflammatory changes of the bronchial epithelium are also present. The patients had severe PAH in which, as in other chronic lung diseases, chronic alveolar hypoxia may play the main pathogenetic role. However, PAH in wood-smoke inhalation-associated lung disease (WSIALD) appears to be more severe than in other forms of interstitial lung disease and tobacco-related COPD. The patients we studied are a selected group and they may represent one end of the spectrum of the WSIALD.

  14. The relation between platelet activation and hypercoagulability in elderly patients with chronic cor pulmonary exacerbation%血小板活性与老年慢性肺心病高凝状态的关系

    Institute of Scientific and Technical Information of China (English)

    邬伟明; 谭劼; 郭永谊; 黄瑾

    2009-01-01

    Objective:To investigate the relation among platelet activation marker(GPⅡb/Ⅲa,CD62p) and amounts of fibrinogen (FG) and of D-dimer (DD) in elderly patients with chronic cor pulmonale exacerbation.Methods:Subjects were divided into four groups (42 elderly patients with chronic cor pulmonale exacerbation,42 elderly patients with chronic cor pulmonale remission stage,30cases of healthy elderly controls and 30 cases of healthy non-elderly controls).Positive rates of GPⅡb/Ⅲa and CD62p were measured with tricolor flow cytometry.We also determined FG and DD in patients with chronic cor pulmonale and in normal controls.Results:Compared with those of chronic cor pulmonale remission stage group,healthy elderly group and healthy non-elderly group,the levels of GPⅡb/Ⅲa,CD62p,FG and DD increased significantly in elderly patients with chronic cor pulmonale exacerbation (all P<0.001).There was a positive correlation between the amount of GPⅡb/Ⅲa or CD62p and the amount of FG and DD in elderly patients with chronic cor pulmonale exacerbation.Conclusion:There is increased coagulation and platelet activity in elderly patients with chronic cor pulmonale exacerbation,and there is a significant correlation between platelet activity and hypercoagulability.%目的:探讨老年慢性肺心病急性加重期患者血小板膜糖蛋白GPⅡb/Ⅲa、CD62p的变化与纤维蛋白原(FG)、D-二聚体(DD)的关系.方法:用三色全血流式细胞术测定42例老年慢性肺心病急性加重期患者及42例缓解期患者外周血中血小板GPⅡb/Ⅲa、CD62p的表达水平,并检测患者FG、DD水平,与30例老年健康对照者及30例非老年健康对照者比较.结果:老年慢性肺心病急性加重期组GPⅡb/Ⅲa、CD62p、FG、DD均明显高于缓解期组、老年健康对照组及非老年健康对照组(均P<0.001).老年慢性肺心病急性加重期组GPⅡb/Ⅲa、CD62p与FG、DD均呈正相关.结论:老年慢性肺心病急性加重期患

  15. Cor Triatriatum Sinister in a French Bulldog

    Directory of Open Access Journals (Sweden)

    Gustavo L. G. Almeida

    2012-01-01

    Full Text Available A 3-year-old male French Bulldog was evaluated due to recent history of intolerance to exercise and coughing. The clinical, radiographic, and echocardiographic findings were consistent with cor triatriatum sinister (CTS, a congenital heart anomaly in which the left atrium is subdivided into two compartments by an abnormal fibromuscular membrane. This defect has been rarely recognized in humans and in domestic cats. To the best of our knowledge, this is the first report of the disorder in the canine species.

  16. Echocardiographic diagnosis of cor triatriatum.

    Science.gov (United States)

    Bett, J H; Graff, R F; Stafford, E G; Dryburgh, L

    1978-08-01

    M-mode echocardiography displayed abnormal echoes in the left atrium and posterior to the mitral leaflets in a child with severe heart failure. Cor triatriatum was demonstrated by angiography and cured by surgical excision. Subsequent echo studies no longer showed the abnormal structure.

  17. Pulmonary granulomatous diseases and pulmonary manifestations of systemic granulomatous disease. Including tuberculosis and nontuberculous mycobacteriosis; Pulmonale granulomatoese Erkrankungen und pulmonale Manifestationen systemischer Granulomatosen. Inklusive Tuberkulose und nichttuberkuloese Mykobakteriosen

    Energy Technology Data Exchange (ETDEWEB)

    Piel, S. [Universitaet Heidelberg, Zentrum fuer interstitielle und seltene Lungenerkrankungen, Pneumologie und Beatmungsmedizin, Thoraxklinik, Heidelberg (Germany); Kreuter, M.; Herth, F. [Universitaet Heidelberg, Zentrum fuer interstitielle und seltene Lungenerkrankungen, Pneumologie und Beatmungsmedizin, Thoraxklinik, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany); Kauczor, H.U. [Universitaetsklinikum Heidelberg, Abteilung fuer Diagnostische und Interventionelle Radiologie, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany); Heussel, C.P. [Universitaet Heidelberg, Abteilung fuer Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany)

    2016-10-15

    Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role. Further radiological modalities are usually not needed in the routine work-up of granulomatous diseases of the chest. In special cases magnetic resonance imaging (MRI) and positron emission tomography (PET)-CT scans play an important role, e. g. detecting cardiac sarcoidosis by cardiac MRI or choline C-11 PET-CT in diagnosing lung carcinoma in scar tissue after tuberculosis. The accuracy of thin-slice CT is very high for granulomatous diseases. In cases of chronic disease and fibrotic interstitial lung disease it is important to perform thin-slice CT in order to diagnose a specific disease pattern. Thin-slice CT is also highly sensitive in detecting disease complications and comorbidities, such as malignancies. Given these indications thin-slice CT is generally accepted in the routine daily practice. A thin-slice CT and an interdisciplinary discussion are recommended in many cases with a suspected diagnosis of pulmonary granulomatous disease due to clinical or radiographic findings. (orig.) [German] Granulome als Zeichen der spezifischen Entzuendung im Lungengewebe treten bei zahlreichen Erkrankungen mit pulmonaler Manifestation auf und stellen einen wichtigen Befund in der Bildgebung dar. Das radiologische Standardverfahren bei pulmonalen Granulomatosen ist meistens die Duennschichtcomputertomographie, in wenigen Faellen, wie z. B. bei Tuberkulose, Sarkoidose und Silikose, spielt die Roentgenthoraxuebersicht immer noch eine wichtige Rolle. Bei der Standardabklaerung der meisten Granulomatosen ist die Hinzunahme weiterer Verfahren nicht

  18. Acute Cor Pulmonale and Right Heat Failure Complicating Ethanol Ablative Therapy: Anesthetic and Radiologic Considerations and Management

    Energy Technology Data Exchange (ETDEWEB)

    Naik, Bhiken, E-mail: bin4n@virginia.edu [University of Virginia, Department of Anesthesiology (United States); Matsumoto, Alan H. [University of Virginia, Department of Radiology and Medical Imaging (United States)

    2013-10-15

    Ethanol is an effective ablative agent used for the treatment of certain solid organ tumors and vascular malformations (VMs). The egress of ethanol beyond the target tissue can be associated with significant changes to the cardiopulmonary system that can lead to cardiac arrest. This article reviews the contemporary role of ethanol in tumor and VM treatment and discusses the physiological mechanisms of acute pulmonary hypertension and cardiovascular collapse. The importance of periprocedural recognition of the hemodynamic changes that can occur with the use of ethanol and the treatment of this condition are discussed.

  19. Cor pulmonale. De rol van het emphyseem en zijn complicaties bij het tekortschieten van het rechter hart

    NARCIS (Netherlands)

    1955-01-01

    Het vraagstuk van de rol, die het emphyseem en zijn complicaties spelen bij de overbelasting van het rechter hart, bracht ons er toe eerst onze aandacht te wijden aan het emphyseem zelf. Wij hebben onder meer stilgestaan bij de bemoeilijkte respiratie (waarbij het aandeel, dat elastische en visceuze

  20. Non-traumatic trans-diaphragmatic intercostal hernia and cor pulmonale in a patient with poorly controlled obstructive sleep apnoea.

    Science.gov (United States)

    Mehdi, Syed Basharath; Madi, Salem; Sudworth, Jordan

    2016-10-28

    Trans-diaphragmatic intercostal hernia is a rare entity. Patient with multiple medical comorbidities, including obstructive sleep apnoea, presents with shortness of breath, leg oedema and a bulging swelling through the right chest wall. CT shows partial herniation of the right lung and liver through intercostal space and an echocardiogram reveals right heart failure. He was treated initially with continuous positive airway pressure with poor response and subsequently treated with adaptive servo ventilation with much better symptomatic relief and treatment tolerance.

  1. Acute cor pulmonale and right heat failure complicating ethanol ablative therapy: anesthetic and radiologic considerations and management.

    Science.gov (United States)

    Naik, Bhiken; Matsumoto, Alan H

    2013-10-01

    Ethanol is an effective ablative agent used for the treatment of certain solid organ tumors and vascular malformations (VMs). The egress of ethanol beyond the target tissue can be associated with significant changes to the cardiopulmonary system that can lead to cardiac arrest. This article reviews the contemporary role of ethanol in tumor and VM treatment and discusses the physiological mechanisms of acute pulmonary hypertension and cardiovascular collapse. The importance of periprocedural recognition of the hemodynamic changes that can occur with the use of ethanol and the treatment of this condition are discussed.

  2. Significance of plasma brain natriuretic peptide in differentiating chronic cor pnlmonale from hypertensive heart failure%血浆脑钠素在肺源性心脏病和高血压性心脏病心力衰竭患者中的比较

    Institute of Scientific and Technical Information of China (English)

    黄蓓洁; 罗艳蓉; 徐晓雯; 李海玲

    2008-01-01

    Objective To study the significance of plasma brain natriuretic peptide(BNP)in differentiating patients with chronic cor pulmonale from those with hypertensive heart failure.Methods Thirty cases of cor pulmonale and 30 of hypertensive heart disease were recruited for the study.Heart rate and arterial partial oxygen pressure(PaO2)were measured for them,as well as plasma level of BNP Was measured by rapid immunofluorescence quantitative analysis.with 30 normal healthy persons as controls.Results As compared with the control group.plasma level of BNP increased significantly in patients with chronic cor pulmonale and hypertensive heart failure(P<0.05),and that in those with hypertensive heart failure[(597±68)ng/L]Was significantly higher than that in those with cot pulmonale[(179±34)ng/L,P<0.05]. Conclusion Plasma level of BNP can be used as an indicator to differentiate cor pulmonale from hypertensive heart failure both with dyspnea.%目的 探讨测定血浆脑钠素水平对鉴别肺源性心脏病和高血压性心脏病所致心力衰竭的意义.方法 肺源性心脏病、高血压性心脏病患者各30例,测定平均心率和PaO2,通过快速免疫荧光定量分析法测定血浆脑钠素水平,与30名正常健康人进行比较和分析.结果 肺源性心脏病和高血压性心脏病两组患者在心力衰竭时血浆脑钠素水平均高于对照组(P<0.05),其中高血压性心脏病组脑钠素[(597±68)ng/L]明显高于肺源性心脏病组[(179±34)ng/ml,P<0.01].结论 肺源性心脏病和高血压性心脏病患者心力衰竭时均表现出呼吸困难,血浆脑钠素可以作为鉴别两者的指标之一.

  3. 38 CFR 4.97 - Schedule of ratings-respiratory system.

    Science.gov (United States)

    2010-07-01

    ... limitation), or; cor pulmonale (right heart failure), or; right ventricular hypertrophy, or; pulmonary...; cor pulmonale (right heart failure), or; right ventricular hypertrophy, or; pulmonary hypertension... thromboembolism with evidence of pulmonary hypertension, right ventricular hypertrophy, or cor pulmonale,...

  4. Pulmonary manifestations in collagen vascular diseases; Pulmonale Manifestationen bei Kollagenosen

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, M.N.A. [Thoraxklinik, Universitaetsklinikum Heidelberg, Abteilung fuer Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany); Kreuter, M. [Thoraxklinik, Universitaetsklinikum Heidelberg, Zentrum fuer interstitielle und seltene Lungenerkrankungen, Pneumologie und Beatmungsmedizin, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany); Kauczor, H.U. [Radiologische Klinik, Universitaetsklinikum Heidelberg, Abteilung fuer Diagnostische und Interventionelle Radiologie, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany); Heussel, C.P. [Thoraxklinik, Universitaetsklinikum Heidelberg, Abteilung fuer Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Heidelberg (Germany); Radiologische Klinik, Universitaetsklinikum Heidelberg, Abteilung fuer Diagnostische und Interventionelle Radiologie, Heidelberg (Germany); Universitaetsklinikum Heidelberg, Translational Lung Research Center (TLRC), Heidelberg (Germany)

    2016-10-15

    Pulmonary complications are frequent in patients with collagen vascular diseases (CVD). Frequent causes are a direct manifestation of the underlying disease, side effects of specific medications and lung infections. The standard radiological procedure for the work-up of pulmonary pathologies in patients with CVD is multidetector computed tomography (MDCT) with thin-slice high-resolution reconstruction. The accuracy of thin-slice CT for the identification of particular disease patterns is very high. The pattern of usual interstitial pneumonia (UIP) representing the direct pulmonary manifestation of rheumatoid arthritis (RA) can be identified with a sensitivity of 45 % and a specificity of 96 %. Both direct pulmonary manifestations, drug-induced toxicity and certain infections can have a similar appearance in thin-slice MDCT in various forms of CVD. Knowledge of the patterns and causes contributes to the diagnostic certainty. At first diagnosis of a CVD and associated pulmonary symptoms thin-slice MDCT is recommended. Clinical, lung function and imaging follow-up examinations should be performed every 6-12 months depending on the results of the MDCT. In every case the individual CT morphological patterns of pulmonary involvement must be identified. The combination of information on the anamnesis, clinical and imaging results is a prerequisite for an appropriate disease management. (orig.) [German] Pulmonale Komplikationen sind bei Patienten mit Kollagenosen keine Seltenheit. Haeufig sind eine direkte Manifestation der Grunderkrankung, eine Nebenwirkung der medikamentoesen Therapie oder eine Lungeninfektion die Ursachen. Das radiologische Standardverfahren zur Klaerung pulmonaler Pathologien bei Patienten mit Kollagenosen ist die Multidetektorcomputertomographie mit duennschichtigen Rekonstruktionen (Duennschicht-MDCT). Die Treffsicherheit der Duennschicht-MDCT ist fuer die Identifikation eines Erkrankungsmusters sehr hoch. So kann beispielsweise das Muster einer

  5. The CORS Network Products and Services

    Science.gov (United States)

    Sella, G.; Snay, R.; Cline, M.; Don, H.

    2008-12-01

    The National Geodetic Survey (NGS) is responsible for defining, providing access and maintaining the National Spatial Reference System (NSRS) which is the legally binding reference frame for the civilian sector of the US Federal Government, and most of the public. With the increasing access to space geodetic data sources, especially GPS, NGS has been transitioning to a space based NSRS. In 1994 NGS created the Continuously Operating Reference Station (CORS) network as a partnership with site operators of continuously operating GNSS sites who were willing to share their data with the public. The network currently contains ~1,200 stations, located mostly in the United States, and is growing at ~ 200 stations a year. The CORS network is particularly dense in the eastern United States, and its GPS observations are used extensively by researchers. NGS is taking a number of steps to improve its CORS related products and services including: 1) More stringent requirements for constructing new CORS as well as operating existing stations, 2) Investigating biases affecting GPS observations collected at CORS, in particular the effects of multipath, and 3) Improving processing software of GPS observables to compute orbits and coordinate computation. This effort has been emphasized because NGS is both an IGS analysis center and the current IGS analysis center coordinator. NGS is reprocessing all CORS data collected since 1994 with the goal of updating the current legally binding geometric reference frame known as NAD83. NGS has also improved and expanded its post-processing web service tools, including the Online Positioning User Service (OPUS). Lastly NGS is now operating a prototype real time GNSS data-delivery service broadcasting in RTCM format via NTRIP.

  6. Some Experience Using SEN2COR

    Science.gov (United States)

    Pflug, Bringfried; Bieniarz, Jakub; Debaecker, Vincent; Louis, Jérôme; Müller-Wilms, Uwe

    2016-04-01

    ESA has developed and launched the Sentinel-2A optical imaging mission that delivers optical data products designed to feed downstream services mainly related to land monitoring, emergency management and security. Many of these applications require accurate correction of satellite images for atmospheric effects to ensure the highest quality of scientific exploitation of Sentinel-2 data. Therefore the atmospheric correction processor Sen2Cor was developed by TPZ V on behalf of ESA. TPZ F and DLR have teamed up in order to provide the calibration and validation of the Level-2A processor Sen2Cor. Level-2A processing is applied to Top-Of-Atmosphere (TOA) Level-1C ortho-image reflectance products. Level-2A main output is the Bottom-Of-Atmosphere (BOA) corrected reflectance product. Additional outputs are an Aerosol Optical Thickness (AOT) map, a Water Vapour (WV) map and a Scene Classification (SC) map with Quality Indicators for cloud and snow probabilities. The poster will present some processing examples of Sen2Cor applied to Sentinel-2A data together with first performance investigations. Different situations will be covered like processing with and without DEM (Digital Elevation Model). Sen2Cor processing is controlled by several configuration parameters. Some examples will be presented demonstrating the influence of different settings of some parameters.

  7. Coréia aguda na gravidez

    Directory of Open Access Journals (Sweden)

    Walter C. Pereira

    1967-12-01

    Full Text Available São apresentados doze casos de coréia aguda observados entre 150.000 gestantes (1/12.500. A maioria dos surtos ocorreu no segundo trimestre da primeira gravidez. A duração média dos sintomas foi de três meses, não tendo sido registrado caso algum de óbito materno. Todos os partos foram espontâneos e normais. Houve apenas um óbito fetal conseqüente a choque hemorrágico. São tecidas considerações a propósito dos aspectos clínico, laboratorial e prognóstico da coréia gravídica, sendo focalizado mais pormenorizadamente o problema fisiopatogênico dessa afecção.

  8. Traumatic arteriovenous fistula due to an old gunshot injury: a victim from the Afghanistan War.

    Science.gov (United States)

    Dabbagh, Ali; Mar'ashi, Ali S; Malek, Bahman

    2007-10-01

    A 75-year-old man referred to the outpatient vascular surgery clinic of Taleghani Hospital (Shaheed Beheshti University of Medicine, Tehran, Iran) due to a local nontender mass in his groin. In his history, it was discovered that the mass had appeared a few months after a gunshot injury. He had a history of shortness of breath with a New York Heart Association functional class fluctuating between II and III, but no history of smoking or addiction. In the physical examination, a 5-cm by 5-cm nonpulsatile mass with engorged vessels was found in the anterior portion of the left groin, which was not tender. An elective arterial angiography revealed an arteriovenous fistula joining the femoral artery to the femoral vein at the left groin. The cardiac assessments revealed cor pulmonale (with a restrictive pattern and diastolic dysfunction) and pulmonary hypertension due to primary pulmonary dysfunction. The patient was anesthetized with a balanced general anesthesia method, considering all relevant cardiac and respiratory monitoring methods and specially withholding drugs increasing pulmonary vascular bed pressure, suppressing the myocardium, or increasing the regurgitant flow across the mitral and, especially, the tricuspid valve. The moment the fistula was closed, a rapid fall in the patient's heart rate was noted, from approximately 60 beats per minute to above 40 beats per minute; this decreased heart rate continued up to a few hours after the surgery and did not accompany any significant hemodynamic derangement including the patient's blood pressure. The patient received his postoperative care in the ordinary surgical ward and was discharged a few days later.

  9. Verification of concurrent systems with VerCors

    NARCIS (Netherlands)

    Amighi, A.; Blom, Stefan; Darabi, Saeed; Huisman, Marieke; Mostowski, Wojciech; Zaharieva, M.; Bernardo, Marco; Damiani, Ferruccio; Hahnle, Reiner; Johnsen, Einar; Schaefer, Ina

    This paper presents the VerCors approach to verification of concurrent software. It first discusses why verification of concurrent software is important, but also challenging. Then it shows how within the VerCors project we use permission-based separation logic to reason about multithreaded Java

  10. The VerCors Project: Setting Up Basecamp

    NARCIS (Netherlands)

    Amighi, Afshin; Blom, Stefan; Huisman, Marieke; Zaharieva-Stojanovski, Marina

    2012-01-01

    This paper describes the first results and on-going work in the VerCors project. The VerCors project is about Verification of Concurrent Data Structures. Its goal is to develop a specification language and program logic for concurrent programs, and in particular for concurrent data structures, as th

  11. The CorA family: structure and function revisited.

    Science.gov (United States)

    Niegowski, D; Eshaghi, S

    2007-10-01

    The CorA family is a group of ion transporters that mediate transport of divalent metal ions across biological membranes. Metal ions are essential elements in most cellular processes and hence the concentrations of ions in cells and organelles must be kept at appropriate levels. Impairment of these systems is implied in a number of pathological conditions. CorA proteins are abundant among the prokaryotic organisms but homologues are present in both human and yeast. The activity of CorA proteins has generally been associated with the transport of magnesium ions but the members of the CorA family can also transport other ions such as cobalt and nickel. The structure of the CorA from Thermotoga maritima, which also was the first structure of a divalent cation transporter determined, has opened the possibilities for understanding the mechanisms behind the ion transport and also corrected a number of assumptions that have been made in the past.

  12. The CorA Mg2+ transporter is a homotetramer.

    Science.gov (United States)

    Warren, Mary Ann; Kucharski, Lisa M; Veenstra, Alexander; Shi, Liang; Grulich, Paul F; Maguire, Michael E

    2004-07-01

    CorA is a primary Mg2+ transporter for Bacteria and Archaea. The C-terminal domain of approximately 80 amino acids forms three transmembrane (TM) segments, which suggests that CorA is a homo-oligomer. A Cys residue was added to the cytoplasmic C terminus (C317) of Salmonella enterica serovar Typhimurium CorA with or without mutation of the single periplasmic Cys191 to Ser; each mutant retained function. Oxidation of the Cys191Ser Cys317 CorA gave a dimer. Oxidation of Cys317 CorA showed a dimer plus an additional band, apparently cross-linked via both Cys317 and C191. To determine oligomer order, intact cells or purified membranes were treated with formaldehyde or carbon disulfide. Higher-molecular-mass bands formed, consistent with the presence of a tetramer. Cross-linking of the Bacillus subtilis CorA expressed in Salmonella serovar Typhimurium similarly indicated a tetramer. CorA periplasmic soluble domains from both Salmonella serovar Typhimurium and the archaeon Methanococcus jannaschii were purified and shown to retain structure. Formaldehyde treatment showed formation of a tetramer. Finally, previous mutagenesis of the CorA membrane domain identified six intramembrane residues forming an apparent pore that interacts with Mg2+ during transport. Each was mutated to Cys. In mutants carrying a single intramembrane Cys residue, spontaneous disulfide bond formation that was enhanced by oxidation with Cu(II)-1,10-phenanthroline was observed between monomers, indicating that these Mg2+-interacting residues within the membrane are very close to their cognate residue on another monomer. Thus, CorA appears to be a homotetramer with a TM segment of one monomer physically close to the same TM segment of another monomer. Copyright 2004 American Society for Microbiology

  13. National Geospatial Data Asset (NGDA) Continuously Operating Reference Stations (CORS)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Geodetic Survey (NGS), an office of NOAA's National Ocean Service, manages a network of Continuously Operating Reference Stations (CORS) that provide...

  14. CORS Station Location at Chaco Culture National Historical Park, NM

    Data.gov (United States)

    National Park Service, Department of the Interior — This is a vector point file showing the location of the continously operating reference station (CORS) at Chaco Culture National Historical Park. The coordinates for...

  15. COR V2: teaching observational research with multimedia courseware.

    Science.gov (United States)

    Blasko, Dawn G; Kazmerski, Victoria A; Torgerson, Carla N

    2004-05-01

    Courseware for Observational Research (COR Version 2) is an interactive multimedia program designed to teach the foundation of the scientific method: systematic observation. COR uses digital video with interactive coding to teach basic concepts, such as creating precise operational definitions; using frequency, interval, and duration coding; developing sampling strategies; and analyzing and interpreting data. Through lessons, a case study, and laboratory exercises, it gradually scaffolds students from teacher-directed learning into self-directed learning. The newest addition to COR is a case study in which students work collaboratively, using their own observations to make recommendations about a child's disruptive behavior in an after-school program. Evaluations of the lessons showed that classes using COR received better grades on their field observations than did those using methods that are more traditional. Students' confidence and knowledge increased as they moved through each section of the program.

  16. Cor triatriatum sinister e hipertensão arterial pulmonar secundária em cão

    Directory of Open Access Journals (Sweden)

    T. Champion

    2014-02-01

    Full Text Available This paper describes the occurrence of cor triatriatum sinister, a rare cardiac malformation in dogs, associated with pulmonary edema and pulmonary hypertension in a 5-year-old Poodle female with history of acute dyspnea and cyanosis. The animal presented acute respiratory failure, heart failure with low cardiac output, progressing to acute tubular necrosis and death. The diagnosis was made posmortem due to the clinical instability of the dog. This malformation was diagnosed by the subdivision of the left atrium into two compartments separated by an abnormal fibromuscular membrane, absence of structural abnormalities of the mitral valve and thickening of pulmonary artery tunica media associated with renal tubular degeneration. The occurrence of cor triatriatum in dogs is most common in the right atrium, defined as cor triatriatum dexter. Additionally, pulmonary arterial hypertension associated with this malformation is described only in humans with this heart defect.

  17. Cor triatriatum dexter: A rare cause of childhood cyanosis

    Directory of Open Access Journals (Sweden)

    Ahmad Rustam bin Mohd Zainudin

    2012-01-01

    Full Text Available Cor triatriatum dexter is a rare congenital heart anomaly where the right atrium is divided into two chambers by a membrane. We report a boy who had persistent mild cyanosis and diagnosed to have cor triatriatum dexter with secundum atrial septal defect by transoesophageal echocardiography. Interestingly, he had persistent mild cyanosis despite insignificant obstruction to the right ventricular inflow and normal pulmonary artery pressure. The pathophysiology, approach to the diagnosis, and mode of treatment are also discussed.

  18. Knotworking In An Interior Décor Process

    DEFF Research Database (Denmark)

    Rasmussen, Mai; Jensen, Rasmus Lund; Fisker, Anna Marie

    2016-01-01

    building projects focusing on energy and cost calculations in 2013 (Kerosuo, Mäki, & Korpela, 2013). A knotworking session lasting only one and a half day was performed to test if it was possible to adopt the principles of Knotworking in an interior décor process. For collecting data on the knotworking......These days, new buildings are being built at Aalborg University in Denmark, why interior décor processes are initiated. Planning the interior décor of Aalborg University is centralized at the Shared Service Center, where internal architects furnish the spaces and buy the selected furniture without...... consulting the end user (Teknisk Forvaltning, 2015). ). But is it possible to make interior décor that fits the utilization of the building?To improve the interior décor process and make the interior décor fit the utilization of the building, the initiated idea was to implement the different interested end...

  19. Permanent transvenous pacemaker implantation in a patient with Cor triatriatum dextrum

    Institute of Scientific and Technical Information of China (English)

    Kun; Xiang; George; V; Moukarbel; Blair; Grubb

    2015-01-01

    Cor triatriatum dextrum is an extremely rare congenital heart abnormality in which the right atrium is separatedinto two chambers by a persistent fibrous membrane. A transvenous approach to place a dual-chamber pacemaker in such patients is technically challenging. We report the first case of a transvenous permanent pacemaker placement in a patient with cor triatriatum dextrum. An 87-year-old woman was diagnosed with paroxysmal atrial fibrillation. She was accidentally found to have cor triatriatum dextrum during the transesophageal echocardiography(TEE) prior to cardioversion. Later during her hospital stay, it was indicated to place a permanant pacemaker due to high grade atrioventricular block. After thorough reviewing TEE imagings, a transvenous catheter-based approach was decided feasible. Patient successfully received a dual chamber pacemaker through left subclavian venous approach. Furthermore in our case, using specially designed pacemaker leads and cautious intra-procedural maneuvering under fluoroscopic guidance ensured procedural success. In summary, a thorough pre-operative evaluation with transesophageal echocardiography is critical for the planning and eventual success of the transvenous placement of rightsided leads.

  20. A hybrid method for damage detection and quantification in advanced X-COR composite structures

    Science.gov (United States)

    Neerukatti, Rajesh Kumar; Rajadas, Abhishek; Borkowski, Luke; Chattopadhyay, Aditi; Huff, Daniel W.

    2016-04-01

    Advanced composite structures, such as foam core carbon fiber reinforced polymer composites, are increasingly being used in applications which require high strength, high in-plane and flexural stiffness, and low weight. However, the presence of in situ damage due to manufacturing defects and/or service conditions can complicate the failure mechanisms and compromise their strength and reliability. In this paper, the capability of detecting damages such as delaminations and foam-core separations in X-COR composite structures using non-destructive evaluation (NDE) and structural health monitoring (SHM) techniques is investigated. Two NDE techniques, flash thermography and low frequency ultrasonics, were used to detect and quantify the damage size and locations. Macro fiber composites (MFCs) were used as actuators and sensors to study the interaction of Lamb waves with delaminations and foam-core separations. The results indicate that both flash thermography and low frequency ultrasonics were capable of detecting damage in X-COR sandwich structures, although low frequency ultrasonic methods were capable of detecting through thickness damages more accurately than flash thermography. It was also observed that the presence of foam-core separations significantly changes the wave behavior when compared to delamination, which complicates the use of wave based SHM techniques. Further, a wave propagation model was developed to model the wave interaction with damages at different locations on the X-COR sandwich plate.

  1. Transcatheter coil embolisation of pulmonary arteriovenous malformations; Transkatheterembolisation pulmonaler arterio-venoeser Fisteln

    Energy Technology Data Exchange (ETDEWEB)

    Wingen, M.; Guenther, R.W. [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik

    2001-07-01

    Evaluation of technical success, complications and long-term results of transcatheter coil embolisation in pulmonary arteriovenous malformations (pAVMs). Material and Methods: Transcatheter embolisations of 46 pAVMs in 14 patients were analysed retrospectively, and, 5 years after treatment, the patients were interviewed by telefone concerning persistent symptoms and complications. Main symptoms before embolisation were dyspnoe (86%), hypoxaemia (100%), cerebral ischemia (21%), and hemoptysis (14%); 11 patients (79%) suffered from hereditary hemorrhagic telangiectasia. Results: Embolisation with an average of 3,9 coils (min. 1, max. 19 coils) per pAVM yielded technical success in all cases. Only two minor complications, transitory pleuritis and a small lung infarction were observed. On follow up examination after 5 years either no residual complaints or substantial improvement of dyspnoe were reported; no patient suffered from neurologic or hemorrhagic complications after the embolisation. Conclusion: Transcatheter embolisation is a safe and minimally invasive therapy for pAVMs and has rightfully replaced surgical resection as the therapy of choice. (orig.) [German] Bewertung der Spiralembolisation pulmonaler AV-Fisteln hinsichtlich Erfolgsrate, Komplikationen und Langzeitergebnissen. Material und Methoden: Retrospektiv wurden die Transkatheterembolisationen von 46 pulmonalen AV-Fisteln bei 14 Patienten ausgewertet und die Patienten bzw. ihre Hausaerzte im Mittel 5 Jahre nach der Intervention telefonisch nachbefragt. Fuehrende Symptome vor der Behandlung waren Belastungsdyspnoe (86%), Hypoxaemie (100%), zerebrale Ischaemien (21%) und Haemoptysen (14%); 11 der Patienten (79%) litten an M. Osler. Ergebnisse: die Embolisation mit im Mittel 3,9 Spiralen (minimal 1, maximal 19 Spiralen) pro Fistel war in allen Faellen technisch erfolgreich, Komplikationen waren mit einer leichten Pleuritis und einer Infarktpneumonie selten und nicht gravierend. Alle nachbefragten

  2. Magnesium Uptake by CorA Is Essential for Viability of the Gastric Pathogen Helicobacter pylori

    OpenAIRE

    Pfeiffer, Jens; Guhl, Johannes; Waidner, Barbara; Kist, Manfred; Bereswill, Stefan

    2002-01-01

    We show here that Mg2+ acquisition by CorA is essential for Helicobacter pylori in vitro, as corA mutants did not grow in media without Mg2+ supplementation. Complementation analysis performed with an Escherichia coli corA mutant revealed that H. pylori CorA transports nickel and cobalt in addition to Mg2+. However, Mg2+ is the dominant CorA substrate, as the corA mutation affected neither cobalt and nickel resistance nor nickel induction of urease in H. pylori. The drastic Mg2+ requirement (...

  3. Hazelnut (Corylus avellana) vicilin Cor a 11: molecular characterization of a glycoprotein and its allergenic activity.

    Science.gov (United States)

    Lauer, Iris; Foetisch, Kay; Kolarich, Daniel; Ballmer-Weber, Barbara K; Conti, Amedeo; Altmann, Friedrich; Vieths, Stefan; Scheurer, Stephan

    2004-10-15

    In Europe, hazelnuts (Corylus avellana) are a frequent cause of food allergies. Several important hazelnut allergens have been previously identified and characterized. Specific N-glycans are known to induce strong IgE responses of uncertain clinical relevance, but so far the allergenic potential of glycoproteins from hazelnut has not been investigated. The aim of the study was the molecular characterization of the glycosylated vicilin Cor a 11 from hazelnut and the analysis of its allergenic activity. Although MALDI-TOF (matrix-assisted laser-desorption ionization-time-of-flight) MS showed that one of two potential glycosylation sites of Cor a 11 was glycosylated, CD spectroscopy indicated that recombinant and natural Cor a 11 share similar secondary structures. Thus to analyse the impact of the glycan residues of Cor a 11 on IgE binding, the allergenic activity of natural glycosylated Cor a 11 and recombinant Cor a 11 was compared. In addition, the IgE sensitization pattern to recombinant Cor a 11, Cor a 1, Cor a 2 and Cor a 8 of 65 hazelnut allergic patients was determined in vitro. The prevalence of IgE reactivity to hazelnut vicilin Cor a 11 was below 50%. Basophil histamine-release assays were used to determine the allergenic activity of both natural and recombinant Cor a 11 in comparison with Cor a 1, a birch (Betula verrucosa) pollen-related major hazelnut allergen. Both forms of Cor a 11 induced mediator release from basophils to a similar extent, indicating that the hazelnut allergic patients had cross-linking IgE antibodies binding to the protein backbone and not to carbohydrate structures. In comparison to Cor a 1, a 10000-fold higher concentration of Cor a 11 was required to induce similar basophil mediator release. In conclusion, the hazelnut vicilin Cor a 11 is a minor allergen both in regard to prevalence and allergenic potency, whereas its glycan does not contribute to its allergenic activity.

  4. Comparison of four variants of a major allergen in hazelnut (Corylus avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01.

    Science.gov (United States)

    Lüttkopf, D; Müller, U; Skov, P S; Ballmer-Weber, B K; Wüthrich, B; Skamstrup Hansen, K; Poulsen, L K; Kästner, M; Haustein, D; Vieths, S

    2002-01-01

    The aim of this study was to produce the Bet v 1-related major hazelnut allergen Cor a 1.0401 and variants thereof as recombinant allergens, and to compare their immuno-reactivity with the major hazel pollen allergen using sera of patients whose hazelnut allergy recently was confirmed by double-blind placebo-controlled food challenges (DBPCFC) in a multicenter study. Total RNA was isolated from immature hazelnuts and transcribed into cDNA. Full length coding DNA obtained by PCR-strategy was subcloned into pTYB11 vector and expressed in E. coli ER2566 cells. Native non-fusion target proteins were purified by DTT-induced self-cleavage of the intein-tagged N-terminal fusion proteins. IgE reactivity of the recombinant allergens was tested by enzyme allergosorbent test (EAST), EAST-inhibition, immunoblot-inhibition and histamine release assays. Four recombinant allergens were produced showing deduced amino acid sequence identities among each other of 97-99%, and were considered as variants Cor a 1.0401 (GenBank Accession no.: AF136945), Cor a 1.0402 (AF323973), Cor a 1.0403 (AF323974) and Cor a 1.0404 (AF323975). Cor a 1.0402 and 03 only differed in a C4S exchange. Cor a 1.0404 had a unique proline residue in position 99. Surprisingly, only 63% identity was revealed with hazel pollen Cor a 1. EAST with 43 sera of patients with positive DBPCFC to hazelnut indicated IgE reactivity to Cor a 1.0401 in 95% of the sera, to Cor a 1.0402 in 93%, to Cor a 1.0403 in 91%, and in only 74% of the sera to the proline variant Cor a 1.0404. The allergenic activity of the four variants was confirmed by histamine release assays in 15 hazelnut-allergic patients stimulated with the four variants and controls. Eleven sera were positive with extract from native hazelnut, 13 with rCor a 1.0401, 12 with rCor a 1.0402, 11 with rCor a 1.0403, and only two with rCor a 1.0404 containing the proline exchange. The high IgE binding variant Cor a 1.0401 showed only partial IgE cross-reactivity with

  5. Magnesium uptake by CorA is essential for viability of the gastric pathogen Helicobacter pylori.

    Science.gov (United States)

    Pfeiffer, Jens; Guhl, Johannes; Waidner, Barbara; Kist, Manfred; Bereswill, Stefan

    2002-07-01

    We show here that Mg(2+) acquisition by CorA is essential for Helicobacter pylori in vitro, as corA mutants did not grow in media without Mg(2+) supplementation. Complementation analysis performed with an Escherichia coli corA mutant revealed that H. pylori CorA transports nickel and cobalt in addition to Mg(2+). However, Mg(2+) is the dominant CorA substrate, as the corA mutation affected neither cobalt and nickel resistance nor nickel induction of urease in H. pylori. The drastic Mg(2+) requirement (20 mM) of H. pylori corA mutants indicates that CorA plays a key role in the adaptation to the low-Mg(2+) conditions predominant in the gastric environment.

  6. Left atrial calcification in a hemodialysis patient with cor triatriatum.

    Science.gov (United States)

    Peces, R; Pobes, A; Rodriguez, M; Simarro, C; Iglesias, G; Simarro, E

    2000-05-01

    Myocardial calcification is a rare manifestation of abnormal calcium metabolism seen in some patients with chronic renal failure. This report describes the transesophageal echocardiographic and spiral computed tomography (CT) findings in a young hemodialysis female with severe secondary hyperparathyroidism. These findings included calcification of the multiperforated membrane of a cor triatriatum and the wall of the left atrium.

  7. The VerCors Tool for Verification of Concurrent Programs

    NARCIS (Netherlands)

    Blom, Stefan; Huisman, Marieke; Jones, Cliff; Pihlajasaari, Pekka; Sun, Jun

    The VerCors tool implements thread-modular static verification of concurrent programs, annotated with functional properties and heap access permissions. The tool supports both generic multithreaded and vector-based programming models. In particular, it can verify multithreaded programs written in

  8. Distribution of the CorA Mg2+ transport system in gram-negative bacteria.

    OpenAIRE

    Smith, R. L.; Maguire, M E

    1995-01-01

    The CorA Mg2+ transport system is the dominant constitutive uptake mechanism in Salmonella typhimurium and Escherichia coli. Southern blot hybridization and PCR techniques were used to screen a panel of 18 additional gram-negative bacterial species for corA homologs. Virtually all strains tested positive for the presence of corA. Thus, corA appears to be ubiquitous within gram-negative bacteria and is likely their major Mg2+ influx system.

  9. Bronchiectasis

    Science.gov (United States)

    ... disability. Possible Complications Complications of bronchiectasis may include: Cor pulmonale Coughing up blood Low oxygen levels (in severe ... PA: Elsevier Saunders; 2016:chap 90. Read More Cor pulmonale Cystic fibrosis Foreign object - inhaled or swallowed Pneumonia - ...

  10. Obesity hypoventilation syndrome (OHS)

    Science.gov (United States)

    ... Reddish skin Signs of right-sided heart failure ( cor pulmonale ), such as swollen legs or feet, shortness of ... High blood pressure ( hypertension ) Right-sided heart failure (cor pulmonale) High blood pressure in the lungs ( pulmonary hypertension )

  11. Poliomyelitis

    Science.gov (United States)

    ... that may result from polio include: Aspiration pneumonia Cor pulmonale (a form of heart failure found on the ... Saunders; 2015:chap 249. Read More Aspiration pneumonia Cor pulmonale Incidence Intestinal obstruction Kidney stones Lymph system Muscle ...

  12. Hemoglobin

    Science.gov (United States)

    ... Failure of the right side of the heart ( cor pulmonale ) Severe chronic obstructive pulmonary disease (COPD) Scarring or ... chronic disease Aplastic anemia Bleeding CBC blood test Cor pulmonale Diabetes Drug-induced immune hemolytic anemia Erythropoietin test ...

  13. RBC count

    Science.gov (United States)

    ... Failure of the right side of the heart ( cor pulmonale ) Dehydration (for example, from severe diarrhea) Kidney tumor ( ... Read More Alport syndrome Anemia CBC blood test Cor pulmonale Dehydration Erythropoietin test Folic acid in diet Glucose- ...

  14. 28 CFR 79.41 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Criteria for Claims by Uranium Miners § 79.41 Definitions. (a) Cor pulmonale means heart disease, including... fibrosis, cor pulmonale related to fibrosis of the lung, silicosis, or pneumoconiosis. (h)...

  15. Primary alveolar hypoventilation

    Science.gov (United States)

    ... the lung blood vessels. This can lead to cor pulmonale (right-sided heart failure). When to Contact a ... chap 18. Read More Breathing - slowed or stopped Cor pulmonale Obesity hypoventilation syndrome (OHS) Review Date 8/21/ ...

  16. Large Artery Stiffness Assessment Using SphygmoCor Technology

    Science.gov (United States)

    Butlin, Mark; Qasem, Ahmad

    2017-01-01

    Large artery stiffness assessment has been an integral part of the SphygmoCor technology since 1998. Aortic stiffness is approximated with non-invasive measurement of carotid-femoral pulse wave velocity, with improvements made with time to make the assessment procedure quicker and more user independent. Also standard in the devices is the ability to reliably calculate the central aortic waveform shape from a peripheral pressure waveform from either the brachial or radial artery. This waveform contains much information beyond peak and trough (systolic and diastolic pressure). Relative waveform features such as the augmentation index, wave reflection magnitude, reflection time index, and subendocardial viability ratio are parameters that are influenced by the stiffness of systemic arteries. This article briefly describes these parameters related to large artery stiffness and provides reference to validation and repeatability studies relative to the clinical use of the SphygmoCor devices. It is beyond the scope to review here the 424 original research articles that have employed SphygmoCor devices in measuring arterial stiffness. Instead, the method of measurement across the devices is described, including tonometry, volumetric displacement through cuff placement around limbs, and ambulatory monitoring. Key population and subpopulation studies are cited where the average stiffness parameter progression with age and gender, as measured by SphygmoCor devices, is quantified in the healthy and general population. Finally, with reference to guidelines from working groups on arterial stiffness and hypertension, the clinical utility of large artery stiffness measurement is discussed in the context of the arterial stiffness parameters provided by the SphygmoCor systems. PMID:28229053

  17. Human Adaptation to the Tibetan Plateau

    Science.gov (United States)

    1991-08-12

    588-91. 32. Penaloza D, Sime F. Chronic cor pulmonale ventilatory drives in Tibetan than Han residents 28. Mahler DA, Cunningham LN, Skrinar GS, due...Tibetan. er (Warren Collins) could be attached. The sured using the dry gas meter and were cor - Diagnosis of CMS was based on a blood remaining...02 carrying-capacity was cor - rial 02 content was lower in the pregnant rected for the carboxyhemoglobin levels Colorado and Tibet women compared to

  18. The CorA Mg2+ Transporter Does Not Transport Fe2+

    OpenAIRE

    Papp, Krisztina M.; Maguire, Michael E.

    2004-01-01

    corA encodes the constitutively expressed primary Mg2+ uptake system of most eubacteria and many archaea. Recently, a mutation in corA was reported to make Salmonella enterica serovar Typhimurium markedly resistant to Fe2+-mediated toxicity. Mechanistically, this was hypothesized to be from an ability of CorA to mediate the influx of Fe2+. Consequently, we directly examined Fe2+ transport and toxicity in wild-type versus corA cells. As determined by direct transport assay, CorA cannot transpo...

  19. 28 CFR 79.46 - Proof of nonmalignant respiratory disease.

    Science.gov (United States)

    2010-07-01

    ... section, and for proof of cor pulmonale must also submit one or more forms of documentation specified in... (d)(3) of this section, and for proof of cor pulmonale must also submit one or more forms of..., cor pulmonale related to fibrosis of the lung, silicosis, and pneumoconiosis: (i) Pathology report...

  20. A rare case of Morgagni hernia associated with cor triatriatum

    Directory of Open Access Journals (Sweden)

    Xicheng Deng

    2015-01-01

    Full Text Available The Morgagni hernia is a rare congenital disorder that is often associated with other anomalies such as congenital heart disease. We present here a case of Morgagni hernia with concomitant cor triatriatum, both of which were repaired in one operation via a sternotomy approach with satisfactory 6 months follow-up. To the best of our knowledge, this is the first case of its kind reported.

  1. Proyecto TIC en Software Libre : 'Cor-Edux'

    OpenAIRE

    Almansa, Dolores

    2005-01-01

    "Del Lápiz al Ratón" es el eslogan del Proyecto "Cor-Edux". En este artículo se detalla el Desarrollo del Proyecto llevado a cabo en el Centro de Educación Infantil "Corazón de María" de Palencia, con él se pretende llevar pedagógicamente el ordenador al aula de Infantil.

  2. Transient Expression of cor Gene in Papaver somniferum

    Directory of Open Access Journals (Sweden)

    Bahman Hosseini

    2011-12-01

    Full Text Available Introduction: Papaver somniferum is the commercial source of morphine and codeine. The isolation of effective genes involved in the morphine biosynthesis of P. somniferum is very important in the production of specific metabolites achieved using metabolic engineering techniques. In this pathway, the key enzyme COR is involved in the conversion of codeinone to codeine and morphinone to morphine. Methods: the gene encoding of this enzyme was isolated using primers designed on the base of gene sequence available on (NCBI for P. somniferum. This gene correct size around (960 bp was first subcloned into pTZ57RIT vector then cloned into expression vectors (pBI121 between BamHI and SacI sites to allow the expression of cor gene driven by the cauliflower mosaic virus 35S promoter. The result was confirmed through different molecular methods e.g. PCR and enzyme digestion by BamHI and SacI. The recombinant plasmid was transformed into the E. coli strain DH5α using a freeze-thaw method. Having selected positive colones on selection medium, plasmid was extracted by miniprep method and recombinant plasmids were selected based on PCR and digestion. The construct was then mobilized in Agrobacterium tumefaciens C58/pGV3850 (KmR RifR. After gene transformation to P. somniferum plants, the agroinfiltration method was also used for transient expression of COR enzyme. Results: evaluation results showed that morphine and codeine were detectable in the leaves of transgenic plants containing cor transgene and there was significant difference in the final production. After completing this experiment for three times, results showed that in 11 sets from 15 sets of leaves experiment tested, main alkaloids (codeine, morphine, papaverin, noscapine and thebaine were detectable. Conclusion: Whereas no signal was detected in non-infiltrated control leaves or in leaves infiltrated with non-recombinant bacteria for morphine and codeine, others such as thebaine and papaverine

  3. Averroes y su uso de aleyas coránicas

    Directory of Open Access Journals (Sweden)

    Josep Puig Montada

    2013-06-01

    Full Text Available El artículo considera el uso que hace Averroes de las citas coránicas en sus obras, y establece diferentes categorías. En la primera se encuentra su obra teológica cuyo título se puede traducir como Los métodos de las pruebas en las doctrinas de la religión, donde las aleyas son la base de estas doctrinas. A la segunda pertenece su comentario medio a la Retórica donde el Corán es citado por ser un modelo literario. La tercera situación es ante todo la de su obra “Tratado definitivo”, la cual tiene forma de dictamen jurídico (fatwâ. La última situación es la de obras filosóficas donde Averroes cita aleyas coránicas para su interpretación de Aristóteles.

  4. A cor verde do endosperma do café On the green color of coffee endosperm

    Directory of Open Access Journals (Sweden)

    Paulo Mazzafera

    1988-01-01

    Full Text Available Realizaram-se comparações entre as sementes dos cultivares Mundo Novo de Coffea arabica, cujo endosperma é verde, com as do cultivar Cera, dessa espécie, de endosperma amarelo, com o objetivo de determinar os componentes responsáveis por aquela cor. Nas análises de clorofilas, flavonóides, diterpenos totais, ácido clorogênico e íons Mg, Ca, K, Fe e B, nenhuma diferença foi verificada entre os dois cultivares, sugerindo que a coloração verde se deva à presença de outros componentes ou que o 'Cera' apresente um componente que não ocorre no 'Mundo Novo' e que inibe o desenvolvimento da cor verde no seu endosperma.A comparison was made between the green seeded Mundo Novo and the yellow seeded Cera cultivars of Coffea arabica, in order to determine the components responsible for the green color of the endosperm. Both cultivars produce beverage of good quality. Chlorophylls, flavonoids, total diterpens, chlorogenic acid, and K, Ca, Mg, Fe and B ions were determined in beans of both cultivars. No differences between cultivars were found on these component contents, what suggests that the green color may be due to other compounds or that the Cera endosperm may have an inhibitor component of the green color of the coffee beans.

  5. The CorA Mg2+ transporter does not transport Fe2+.

    Science.gov (United States)

    Papp, Krisztina M; Maguire, Michael E

    2004-11-01

    corA encodes the constitutively expressed primary Mg2+ uptake system of most eubacteria and many archaea. Recently, a mutation in corA was reported to make Salmonella enterica serovar Typhimurium markedly resistant to Fe2+-mediated toxicity. Mechanistically, this was hypothesized to be from an ability of CorA to mediate the influx of Fe2+. Consequently, we directly examined Fe2+ transport and toxicity in wild-type versus corA cells. As determined by direct transport assay, CorA cannot transport Fe2+ and Fe2+ does not potently inhibit CorA transport of 63Ni2+. Mg2+ can, relatively weakly, inhibit Fe2+ uptake, but inhibition is not dependent on the presence of a functional corA allele. Although excess Fe2+ was slightly toxic to S. enterica serovar Typhimurium, we were unable to elicit a significant differential sensitivity in a wild-type versus a corA strain. We conclude that CorA does not transport Fe2+ and that the relationship, if any, between iron toxicity and corA is indirect.

  6. Co2+ selectivity of Thermotoga maritima CorA and its inability to regulate Mg2+ homeostasis present a new class of CorA proteins.

    Science.gov (United States)

    Xia, Yu; Lundbäck, Anna-Karin; Sahaf, Newsha; Nordlund, Gustav; Brzezinski, Peter; Eshaghi, Said

    2011-05-06

    CorA is a family of divalent cation transporters ubiquitously present in bacteria and archaea. Although CorA can transport both Mg(2+) and Co(2+) almost equally well, its main role has been suggested to be that of primary Mg(2+) transporter of prokaryotes and hence the regulator of Mg(2+) homeostasis. The reason is that the affinity of CorA for Co(2+) is relatively low and thus considered non-physiological. Here, we show that Thermotoga maritima CorA (TmCorA) is incapable of regulating the Mg(2+) homeostasis and therefore cannot be the primary Mg(2+) transporter of T. maritima. Further, our in vivo experiments confirm that TmCorA is a highly selective Co(2+) transporter, as it selects Co(2+) over Mg(2+) at >100 times lower concentrations. In addition, we present data that show TmCorA to be extremely thermostable in the presence of Co(2+). Mg(2+) could not stabilize the protein to the same extent, even at high concentrations. We also show that addition of Co(2+), but not Mg(2+), specifically induces structural changes to the protein. Altogether, these data show that TmCorA has the role of being the transporter of Co(2+) but not Mg(2+). The physiological relevance and requirements of Co(2+) in T. maritima is discussed and highlighted. We suggest that CorA may have different roles in different organisms. Such functional diversity is presumably a reflection of minor, but important structural differences within the CorA family that regulate the gating, substrate selection, and transport.

  7. The AbioCor totally implantable replacement heart.

    Science.gov (United States)

    Holmes, Elena C

    2003-01-01

    An artificial heart with adequate circulatory support and an acceptable quality of life remains one of the holy grails of heart failure medicine and surgery. The totally implantable AbioCor is powered electrically via an external power source and has no skin-piercing cables. To date, seven critically ill patients with end-stage heart failure have been implanted with it. Four patients survived beyond 2 months, and two patients were discharged from the hospital. Both enjoyed improved quality of life with frequent social excursions; another patient is about to be discharged. While three patients died, early trials suggest that this device holds promise.

  8. RNase III controls the degradation of corA mRNA in Escherichia coli.

    Science.gov (United States)

    Lim, Boram; Sim, Se-Hoon; Sim, Minji; Kim, Kyungsub; Jeon, Che Ok; Lee, Younghoon; Ha, Nam-Chul; Lee, Kangseok

    2012-05-01

    In Escherichia coli, the corA gene encodes a transporter that mediates the influx of Co(2+), Mg(2+), and Ni(2+) into the cell. During the course of experiments aimed at identifying RNase III-dependent genes in E. coli, we observed that steady-state levels of corA mRNA as well as the degree of cobalt influx into the cell were dependent on cellular concentrations of RNase III. In addition, changes in corA expression levels by different cellular concentrations of RNase III were closely correlated with degrees of resistance of E. coli cells to Co(2+) and Ni(2+). In vitro and in vivo cleavage analyses of corA mRNA identified RNase III cleavage sites in the 5'-untranslated region of the corA mRNA. The introduction of nucleotide substitutions at the identified RNase III cleavage sites abolished RNase III cleavage activity on corA mRNA and resulted in prolonged half-lives of the mRNA, which demonstrates that RNase III cleavage constitutes a rate-determining step for corA mRNA degradation. These findings reveal an RNase III-mediated regulatory pathway that functions to modulate corA expression and, in turn, the influx of metal ions transported by CorA in E. coli.

  9. Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate.

    Science.gov (United States)

    Wang, Shi-Zhen; Chen, Yong; Sun, Zhan-Hua; Zhou, Qiang; Sui, Sen-Fang

    2006-09-15

    CorA is a primary Mg2+ transporter in bacteria, which also mediates influx of Ni2+ and Co2+. Topological studies suggested that it could be divided into a large soluble periplasmic domain (PPD) and three membrane-spanning alpha-helixes. In the present study, glutathione S-transferase (GST) fusion Escherichia coli CorA PPD was purified by GST affinity chromatography, and PPD was obtained by on-column thrombin digestion. Size-exclusion chromatography indicated that purified PPD exists as a homotetramer. Single particle electron microscopy analysis of PPD and two-dimensional crystals of GST-PPD indicated that E. coli CorA PPD is a pyramid-like homotetramer with a central cavity. Comparison of the CD spectra of full-length CorA and PPD also suggested that PPD has similar secondary structure to the full-length CorA. Dissociation constants for CorA and PPD with their substrates, determined by dose-dependent fluorescence quench of ligands, suggested that purified PPD retains its substrate binding ability as native CorA. The CorA PPD structure described here may provide structural information for the E. coli CorA functional oligomeric state.

  10. Detection of lung nodules. New opportunities in chest radiography; Detektion pulmonaler Rundherde. Neue Moeglichkeiten der Thoraxradiographie

    Energy Technology Data Exchange (ETDEWEB)

    Poetter-Lang, S. [Medizinische Universitaet Wien, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Department of Biomedical Imaging and Image-Guided Therapy, Wien (Austria); Schalekamp, S. [Radboud University Nijmegen Medical Center, Nijmegen (Netherlands); Schaefer-Prokop, C. [Radboud University Nijmegen Medical Center, Nijmegen (Netherlands); Meander Medical Center Amersfoort, Amersfoort (Netherlands); Uffmann, M. [Landesklinikum Neunkirchen, Abteilung fuer Radiodiagnostik, Neunkirchen (Germany)

    2014-05-15

    ;'anatomische Rauschen'' durch Reduktion ueberlagernder Strukturen im Thoraxroentgen. Computergestuetzte Diagnosesysteme (CAD) erhoehen die Aufmerksamkeit der Radiologen fuer bestimmte suspekte Areale. Die zukunftsweisenden Bildverarbeitungsmethoden konnten deutliche Steigerungen bei der Detektion pulmonaler Rundherde im Thoraxroentgen zeigen und so die Wertigkeit dieser Methode im Vergleich zu Schnittbildverfahren wie der CT wieder steigern. Viele dieser Methoden werden wahrscheinlich in naher Zukunft in den klinischen Alltag eingebunden werden, wobei hier Softwareerweiterungen Vorteile zeigen, da sie einfacher in die radiologischen Abteilungen integriert werden koennen und oft auch wesentlich kostenguenstiger sind als Hardwarekomponenten. (orig.)

  11. Crystal structure of the CorA Mg2+ transporter.

    Science.gov (United States)

    Lunin, Vladimir V; Dobrovetsky, Elena; Khutoreskaya, Galina; Zhang, Rongguang; Joachimiak, Andrzej; Doyle, Declan A; Bochkarev, Alexey; Maguire, Michael E; Edwards, Aled M; Koth, Christopher M

    2006-04-06

    The magnesium ion, Mg2+, is essential for myriad biochemical processes and remains the only major biological ion whose transport mechanisms remain unknown. The CorA family of magnesium transporters is the primary Mg2+ uptake system of most prokaryotes and a functional homologue of the eukaryotic mitochondrial magnesium transporter. Here we determine crystal structures of the full-length Thermotoga maritima CorA in an apparent closed state and its isolated cytoplasmic domain at 3.9 A and 1.85 A resolution, respectively. The transporter is a funnel-shaped homopentamer with two transmembrane helices per monomer. The channel is formed by an inner group of five helices and putatively gated by bulky hydrophobic residues. The large cytoplasmic domain forms a funnel whose wide mouth points into the cell and whose walls are formed by five long helices that are extensions of the transmembrane helices. The cytoplasmic neck of the pore is surrounded, on the outside of the funnel, by a ring of highly conserved positively charged residues. Two negatively charged helices in the cytoplasmic domain extend back towards the membrane on the outside of the funnel and abut the ring of positive charge. An apparent Mg2+ ion was bound between monomers at a conserved site in the cytoplasmic domain, suggesting a mechanism to link gating of the pore to the intracellular concentration of Mg2+.

  12. Development of the cat-owner relationship scale (CORS).

    Science.gov (United States)

    Howell, Tiffani J; Bowen, Jonathan; Fatjó, Jaume; Calvo, Paula; Holloway, Anna; Bennett, Pauleen C

    2017-03-07

    Characteristics of the human-animal bond can be influenced by both owner-related and pet-related factors, which likely differ between species. Three studies adapted the Monash Dog-Owner Relationship Scale (MDORS) to permit assessment of human-cat interactions as perceived by the cat's owner. In Study 1293 female cat owners completed a modified version of the MDORS, where 'dog' was replaced with 'cat' for all items. Responses were compared with a matched sample of female dog owners. A partial least squares discriminant analysis revealed systematic differences between cat and dog owners in the Dog (Cat)-Owner Interaction subscale (MDORS subscale 1), but not for Perceived Emotional Closeness or Perceived Costs (Subscales 2 and 3). Study 2 involved analysis of free-text descriptions of cat-owner interactions provided by 61 female cat owners. Text mining identified key words which were used to create additional questions for a new Cat-Owner Interaction subscale. In Study 3, the resulting cat-owner relationship scale (CORS) was tested in a group of 570 cat owners. The main psychometric properties of the scale, including internal consistency and factor structure, were evaluated. We propose that this scale can be used to accurately assess owner perceptions of their relationship with their cat. A modified scale, combining items from the CORS and MDORS (a C/DORS), is also provided for when researchers would find it desirable to compare human-cat and human-dog interactions.

  13. Continuously Operating Reference Stations (CORS), CORs stations operating in Bisbee and Willcox, Published in 2001, 1:600 (1in=50ft) scale, Cochise County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Continuously Operating Reference Stations (CORS) dataset, published at 1:600 (1in=50ft) scale, was produced all or in part from Field Survey/GPS information as...

  14. Strength comparison between cold-inducible promoters of Arabidopsis cor15a and cor15b genes in potato and tobacco.

    Science.gov (United States)

    Li, Meng; Wang, Xiaohuan; Cao, Yang; Liu, Xun; Lin, Yuan; Ou, Yongbin; Zhang, Huiling; Liu, Jun

    2013-10-01

    The cold-inducible promoter is ideal for regulating ectopic gene expression in plants to cope with the cold stress. The promoters of two cold-regulated genes, cor15a and cor15b, were cloned from Arabidopsis thaliana and their strengths were assayed in potato and tobacco. Although the cis-element composition and cold-inducible property were similar between the two promoters, the cor15b promoter showed significantly higher activity than the cor15a promoter in both potato and tobacco. In order to elucidate the factors determining this discrepancy, cor15a and cor15b promoters were separately truncated from 5'-end to construct short promoters with similar size containing a single C-repeat/dehydration-responsive element (CRT/DRE). Subsequently, two synthetic promoters were constructed by swapping the flanking sequences of CRT/DRE in the truncated promoters. The promoter strength comparison demonstrated that the flanking sequence could affect the promoter strength. These findings provide a potential regulatory mechanism to control the promoter strength without impact on other properties.

  15. Structural and Functional Characterization of the Hazelnut Allergen Cor a 8.

    Science.gov (United States)

    Offermann, Lesa R; Bublin, Merima; Perdue, Makenzie L; Pfeifer, Sabine; Dubiela, Pawel; Borowski, Tomasz; Chruszcz, Maksymilian; Hoffmann-Sommergruber, Karin

    2015-10-21

    Nonspecific lipid transfer proteins (nsLTPs) are basic proteins, stabilized by four disulfide bonds, and are expressed throughout the plant kingdom. These proteins are also known as important allergens in fruits and tree nuts. In this study, the nsLTP from hazelnuts, Cor a 8, was purified and its crystal structure determined. The protein is stable at low pH and refolds after thermal denaturation. Molecular dynamics simulations were used to provide an insight into conformational changes of Cor a 8 upon ligand binding. When known epitope areas from Pru p 3 were compared to those of Cor a 8, differences were obvious, which may contribute to limited cross-reactivity between peach and hazelnut allergens. Differences in epitope regions may contribute to limited cross-reactivity between Cor a 8 and nsLTPs from other plant sources. The structure of Cor a 8 represents the first resolved structure of a hazelnut allergen.

  16. Structural and Functional Characterization of the Hazelnut Allergen Cor a 8

    Science.gov (United States)

    2015-01-01

    Nonspecific lipid transfer proteins (nsLTPs) are basic proteins, stabilized by four disulfide bonds, and are expressed throughout the plant kingdom. These proteins are also known as important allergens in fruits and tree nuts. In this study, the nsLTP from hazelnuts, Cor a 8, was purified and its crystal structure determined. The protein is stable at low pH and refolds after thermal denaturation. Molecular dynamics simulations were used to provide an insight into conformational changes of Cor a 8 upon ligand binding. When known epitope areas from Pru p 3 were compared to those of Cor a 8, differences were obvious, which may contribute to limited cross-reactivity between peach and hazelnut allergens. Differences in epitope regions may contribute to limited cross-reactivity between Cor a 8 and nsLTPs from other plant sources. The structure of Cor a 8 represents the first resolved structure of a hazelnut allergen. PMID:26417906

  17. Cor triatriatum sinistrum in adults, a case presentation

    Directory of Open Access Journals (Sweden)

    Reinaldo Elías Milán Castillo

    2015-11-01

    Full Text Available Cor triatriatum sinistrum is a rare congenital cardiopathy found in about 0, 4 % of inbornheart diseases diagnosed by necropsy, and it is clinically found in less than 0, 1% of the clinical congenital cardiopathies. It was described by Church for the first time in 1868 as a left atrium divided by an abnormal septum, its definitive name was given by Borst in 1905,and the first surgical treatment was performed by Vineberg and Gialloreto in 1956. It is very unusual to diagnose it in an adult, since most of the patients are diagnosed during their childhood. In this case, a 55-year-old female patient was sent for cardiological evaluation complaining of dyspnea and chest dyscomfort during physical activity.

  18. Strategic planning of INA-CORS development for public service and tectonic deformation study

    Science.gov (United States)

    Syetiawan, Agung; Gaol, Yustisi Ardhitasari Lumban; Safi'i, Ayu Nur

    2017-07-01

    GPS technology can be applied for surveying, mapping and research purposes. The simplicity of GPS technology for positioning make it become the first choice for survey compared with another positioning method. GPS can measure a position with various accuracy level based on the measurement method. In order to facilitate the GPS positioning, many organizations are establishing permanent GPS station. National Geodetic Survey (NGS) called it as Continuously Operating Reference Stations (CORS). Those devices continuously collect and record GPS data to be used by users. CORS has been built by several government agencies for particular purposes and scattered throughout Indonesia. Geospatial Information Agency (BIG) as a geospatial information providers begin to compile a grand design of Indonesia CORS (INA-CORS) that can be used for public service such as Real Time Kinematic (RTK), RINEX data request, or post-processing service and for tectonic deformation study to determine the deformation models of Indonesia and to evaluate the national geospatial reference system. This study aims to review the ideal location to develop CORS network distribution. The method was used is to perform spatial analysis on the data distribution of BIG and BPN CORS overlayed with Seismotectonic Map of Indonesia and land cover. The ideal condition to be achieved is that CORS will be available on each radius of 50 km. The result showed that CORS distribution in Java and Nusa Tenggara are already tight while on Sumatra, Celebes and Moluccas are still need to be more tighten. Meanwhile, the development of CORS in Papua will encounter obstacles toward road access and networking. This analysis result can be used as consideration for determining the priorities of CORS development in Indonesia.

  19. The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium.

    Science.gov (United States)

    Papp-Wallace, Krisztina M; Nartea, Margaret; Kehres, David G; Porwollik, Steffen; McClelland, Michael; Libby, Stephen J; Fang, Ferric C; Maguire, Michael E

    2008-10-01

    CorA is the primary Mg(2+) channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.

  20. The CorA Mg2+ Channel Is Required for the Virulence of Salmonella enterica Serovar Typhimurium▿ †

    OpenAIRE

    Papp-Wallace, Krisztina M.; Nartea, Margaret; Kehres, David G.; Porwollik, Steffen; McClelland, Michael; Libby, Stephen J.; Ferric C. Fang; Maguire, Michael E.

    2008-01-01

    CorA is the primary Mg2+ channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.

  1. 坐标转换在 CORS 中的应用%Apply on Coordinate Transformation in CORS

    Institute of Scientific and Technical Information of China (English)

    刘立

    2016-01-01

    介绍了三维七参数在CORS系统中的应用及用两种方法求解CGCS2000到西安80坐标的三维七参数。利用浙江省CORS基准站分析这两种方法的优劣,对于西安80的大地高往往是未知的,因此对西安80大地高的求解很重要。求解三维七参数用三参数和三维七参数法比只用三维七参数法解算的中误差和坐标转换残差都有大幅度提高。%The application of three‐dimensional seven parameter in CORS system is in‐troduced in this paper ,utilizing two methods to solve the three‐dimensional seven parameters of CGCS2000 to Xi′an 80 coordinates .Based on the analysis of the advantages and disadvan‐tages of these two methods by suing data of CORS in Zhejiang province .For height of Xi′an 80 is often unknow n ,so it is important to solve the 80 geodetic height of Xi'an .Seven param‐eters of three‐dimensional solution with three parameters and three‐dimensional seven param‐eters compared with only seven dimensional parameter method has greatly improved in the residual error and coordinate transformation .

  2. OpenCOR: a modular and interoperable approach to computational biology

    Directory of Open Access Journals (Sweden)

    Alan eGarny

    2015-02-01

    Full Text Available Computational biologists have been developing standards and formats for nearly two decades, with the aim of easing the description and exchange of experimental data, mathematical models, simulation experiments, etc. One of those efforts is CellML (cellml.org, an XML-based markup language for the encoding of mathematical models.Early CellML-based environments include COR and OpenCell. However, both of those tools have limitations and were eventually replaced with OpenCOR (opencor.ws. OpenCOR is an open source modeling environment that is supported on Windows, Linux and OS X. It relies on a modular approach, which means that all of its features come in the form of plugins. Those plugins can be used to organize, edit, simulate and analyze models encoded in the CellML format.We start with an introduction to CellML and two of its early adopters, which limitations eventually led to the development of OpenCOR. We then go onto describing the general philosophy behind OpenCOR, as well as describing its openness and its development process. Next, we illustrate various aspects of OpenCOR, such as its user interface and some of the plugins that come bundled with it (e.g. its editing and simulation plugins. Finally, we discuss some of the advantages and limitations of OpenCOR before drawing some concluding remarks.

  3. OpenCOR: a modular and interoperable approach to computational biology

    Science.gov (United States)

    Garny, Alan; Hunter, Peter J.

    2015-01-01

    Computational biologists have been developing standards and formats for nearly two decades, with the aim of easing the description and exchange of experimental data, mathematical models, simulation experiments, etc. One of those efforts is CellML (cellml.org), an XML-based markup language for the encoding of mathematical models. Early CellML-based environments include COR and OpenCell. However, both of those tools have limitations and were eventually replaced with OpenCOR (opencor.ws). OpenCOR is an open source modeling environment that is supported on Windows, Linux and OS X. It relies on a modular approach, which means that all of its features come in the form of plugins. Those plugins can be used to organize, edit, simulate and analyze models encoded in the CellML format. We start with an introduction to CellML and two of its early adopters, which limitations eventually led to the development of OpenCOR. We then go onto describing the general philosophy behind OpenCOR, as well as describing its openness and its development process. Next, we illustrate various aspects of OpenCOR, such as its user interface and some of the plugins that come bundled with it (e.g., its editing and simulation plugins). Finally, we discuss some of the advantages and limitations of OpenCOR before drawing some concluding remarks. PMID:25705192

  4. Cation hexaammines are selective and potent inhibitors of the CorA magnesium transport system.

    Science.gov (United States)

    Kucharski, L M; Lubbe, W J; Maguire, M E

    2000-06-02

    Cation hexaammines and related compounds are chemically stable analogs of the hydrated form of cations, particularly Mg(2+). We tested the ability of several of these compounds to inhibit transport by the CorA or MgtB Mg(2+) transport systems or the PhoQ receptor kinase for Mg(2+) in Salmonella typhimurium. Cobalt(III)-, ruthenium(II)-, and ruthenium(III)-hexaammines were potent inhibitors of CorA-mediated influx. Cobalt(III)- and ruthenium(III)chloropentaammines were slightly less potent inhibitors of CorA. The compounds inhibited uptake by the bacterial S. typhimurium CorA and by the archaeal Methanococcus jannaschii CorA, which bear only 12% identity in the extracellular periplasmic domain. Cation hexaammines also inhibited growth of S. typhimurium strains dependent on CorA for Mg(2+) uptake but not of isogenic strains carrying a second Mg(2+) uptake system. In contrast, hexacyano-cobaltate(III) and ruthenate(II)- and nickel(II)hexaammine had little effect on uptake. The inhibition by the cation hexaammines was selective for CorA because none of the compounds had any effect on transport by the MgtB P-type ATPase Mg(2+) transporter or the PhoQ Mg(2+) receptor kinase. These results demonstrate that cation hexaammines are potent and highly selective inhibitors of the CorA Mg(2+) transport system and further indicate that the initial interaction of the CorA transporter is with a fully hydrated Mg(2+) cation.

  5. Comparison of four variants of a major allergen in hazelnut (Corylus avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01

    DEFF Research Database (Denmark)

    Lüttkopf, D; Müller, U; Skov, P S

    2002-01-01

    The aim of this study was to produce the Bet v 1-related major hazelnut allergen Cor a 1.0401 and variants thereof as recombinant allergens, and to compare their immuno-reactivity with the major hazel pollen allergen using sera of patients whose hazelnut allergy recently was confirmed by double......-blind placebo-controlled food challenges (DBPCFC) in a multicenter study. Total RNA was isolated from immature hazelnuts and transcribed into cDNA. Full length coding DNA obtained by PCR-strategy was subcloned into pTYB11 vector and expressed in E. coli ER2566 cells. Native non-fusion target proteins were...... residue in position 99. Surprisingly, only 63% identity was revealed with hazel pollen Cor a 1. EAST with 43 sera of patients with positive DBPCFC to hazelnut indicated IgE reactivity to Cor a 1.0401 in 95% of the sera, to Cor a 1.0402 in 93%, to Cor a 1.0403 in 91%, and in only 74% of the sera...

  6. RNase III Controls the Degradation of corA mRNA in Escherichia coli

    OpenAIRE

    Lim, Boram; Sim, Se-Hoon; Sim, Minji; Kim, Kyungsub; Jeon, Che Ok; Lee, Younghoon; Ha, Nam-Chul; Lee, Kangseok

    2012-01-01

    In Escherichia coli, the corA gene encodes a transporter that mediates the influx of Co2+, Mg2+, and Ni2+ into the cell. During the course of experiments aimed at identifying RNase III-dependent genes in E. coli, we observed that steady-state levels of corA mRNA as well as the degree of cobalt influx into the cell were dependent on cellular concentrations of RNase III. In addition, changes in corA expression levels by different cellular concentrations of RNase III were closely correlated with...

  7. Coding Manual for the U.S. Army Aviation Epidemiology Data Register

    Science.gov (United States)

    1991-01-01

    voltage Ventricular hypertrophies G720 LVH (voltage plus ST-T wave changes) G721 RVH (tall R type) G722 RVH (rSR’ type) G723 Acute cor pulmonale G724...Chronic cor pulmonale G725 Emphysema without cor pulmonale G726 Age related right ventricular preponderance G727 Biventricular enlargement G728 Septal...Diseases Volume 3: Tabular List and Alphabetic Index of Procedures The first volume contains the code numbers and their cor - responding diagnoses. The

  8. 糖化血红蛋白与肺心病肺动脉高压间关系的研究%Relationship between glycosylated hemoglobin and cor pulmonale with pulmonary hypertension

    Institute of Scientific and Technical Information of China (English)

    马明华; 张韵琴; 李玉明; 高铁林; 丁爱华

    2001-01-01

    目的探讨GHb与肺心病肺动脉高压间的关系.方法肺心病组30例、COPD组20例、对照组20例,取空腹静脉血,用亲和层析微柱法测得GHb的含量;同时采动脉血,用血气分析仪测定pH、PaCO2和PaO2;用彩色多普勒电脑声像仪记录肺动脉瓣舒张期返流频谱,并测量三尖瓣收缩期返流最高流速.结果肺心病组的CHb、PaCO2和PAP明显高于COPD组及对照组,(P<0.05);PaO2和pH明显低于COPD组和对照组(P<0.05).结论GHb增高与缺氧、二氧化碳潴留及pH降低有关,PAP升高与GHb增高有明显关系.

  9. THE EFFECT OF DÉCOR PAPER AND RESIN TYPE ON THE PHYSICAL, MECHANICAL, AND SURFACE QUALITY PROPERTIES OF PARTICLEBOARDS COATED WITH IMPREGNATED DÉCOR PAPERS

    Directory of Open Access Journals (Sweden)

    Abdullah Istek

    2010-03-01

    Full Text Available he objective of this study is to evaluate the effect of décor paper and resin type on physical properties such as density, moisture content, water absorption and thickness swelling; mechanic properties such as bending strength, modulus of elasticity in bending, and surface quality properties of the particleboards overlaid with non-impregnated and impregnated papers. As a result, specimens laminated with MF impregnated papers showed better performance than those laminated with UF impregnated papers. Resin type and décor papers affected the physical, mechanical (with exception of tension strength and surface properties of laminated particleboards. Physical and mechanical properties of laminated particleboard were significantly improved compared to un-laminated particleboards. It was found that décor paper affected the surface properties such as impact, scratch, and abrasion, resistance to staining and cigarette burn. However, it did not change the cracking and steaming properties of laminated samples.

  10. Dynamic triaxial compression experiments on Cor-Tuf specimens

    Science.gov (United States)

    Mondal, Alex B.

    A set of dynamic triaxial compression experiments at 50 MPa, 100 MPa, and 200 MPa confinement have been conducted with a modified Kolsky bar on cylindrical ultra high strength concrete Cor-Tuf specimens of diameter 19 mm and length of 12.7 mm. The experiment is composed of a hydrostatic phase which occurs at a quasi-static strain rate followed by a dynamic shear phase which occurs at a high strain rate. A set of 28 experiments were conducted at strain rates of 100 s-1 and 200 s-1. The experiments show that the fracture strength of the material increases under the test conditions. The specimens showed higher strength in the dynamic confined experiments than both the quasi-static TXC tests and the unconfined dynamic tests. The strength increase was attributed to specimen size difference and not a strain rate or confinement effect. Although the trend towards brittle ductile transition is observed the specimens were not tested in a high enough confinement for the phase change to occur.

  11. GNSS antenna array-aided CORS ambiguity resolution

    Science.gov (United States)

    Li, Bofeng; Teunissen, Peter J. G.

    2014-04-01

    Array-aided precise point positioning is a measurement concept that uses GNSS data, from multiple antennas in an array of known geometry, to realize improved GNSS parameter estimation proposed by Teunissen (IEEE Trans Signal Process 60:2870-2881, 2012). In this contribution, the benefits of array-aided CORS ambiguity resolution are explored. The mathematical model is formulated to show how the platform-array data can be reduced and how the variance matrix of the between-platform ambiguities can profit from the increased precision of the reduced platform data. The ambiguity resolution performance will be demonstrated for varying scenarios using simulation. We consider single-, dual- and triple-frequency scenarios of geometry-based and geometry-free models for different number of antennas and different standard deviations of the ionosphere-weighted constraints. The performances of both full and partial ambiguity resolution (PAR) are presented for these different scenarios. As the study shows, when full advantage is taken of the array antennas, both full and partial ambiguity resolution can be significantly improved, in some important cases even enabling instantaneous ambiguity resolution. PAR widelaning and its suboptimal character are hereby also illustrated.

  12. Contribution of GNSS CORS Infrastructure to the Mission of Modern Geodesy and Status of GNSS CORS in Thailand

    Directory of Open Access Journals (Sweden)

    Chalermchon Satirapod

    2011-01-01

    Full Text Available Geodesy is the science of measuring and mapping the geometry, orientation and gravity field of the Earth including the associated variations with time. Geodesy has also provided the foundation for high accuracy surveying and mapping. Modern Geodesy involves a range of space and terrestrial technologies that contribute to our knowledge of the solid earth, atmosphere and oceans. These technologies include: Global Positioning System/Global Navigation Satellite Systems (GPS/GNSS, Satellite Laser Ranging (SLR, Very Long Baseline Interferometry (VLBI, Satellite Altimetry, Gravity Mapping Missions such as GRACE, CHAMP and GOCE, satelliteborne Differential Interferometric Synthetic Aperture Radar (DInSAR, Absolute and Relative Gravimetry, and Precise Terrestrial Surveying (Levelling and Traversing. A variety of services have been established in recent years to ensure high accuracy and reliable geodetic products to support geoscientific research. The reference frame defined by Modern Geodesy is now the basis for most national and regional datums. Furthermore, the GPS/GNSS technology is a crucial geopositioning tool for both Geodesy and Surveying. There is therefore a blurring of the distinction between geodetic and surveying GPS/GNSS techniques, and increasingly the ground infrastructure of continuously operating reference stations (CORS receivers attempts to address the needs of both geodesists and other positioning professionals. Yet Geodesy is also striving to increase the level of accuracy by a factor of ten over the next decade in order to address the demands of “global change” studies. The Global Geodetic Observing System (GGOS is an important component of the International Association of Geodesy. GGOS aims to integrate all geodetic observations in order to generate a consistent high quality set of geodetic parameters for monitoring the phenomena and processes within the “System Earth”. Integration implies the inclusion of all relevant

  13. Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes.

    Science.gov (United States)

    De Amicis, Karine M; Freschi de Barros, Samar; Alencar, Raquel E; Postól, Edilberto; Martins, Carlo de Oliveira; Arcuri, Helen Andrade; Goulart, Cibelly; Kalil, Jorge; Guilherme, Luiza

    2014-07-07

    Streptococcus pyogenes is responsible for infections as pharyngitis, sepsis, necrotizing fasciitis and streptococcal toxic shock syndrome. The M protein is the major bacterial antigen and consists of both polymorphic N-terminal portion and a conserved region. In the present study, we analyzed the in vitro ability of StreptInCor a C-terminal candidate vaccine against S. pyogenes to induce antibodies to neutralize/opsonize the most common S. pyogenes strains in Sao Paulo by examining the recognition by sera from StreptInCor immunized mice. We also evaluated the presence of cross-reactive antibodies against human heart valve tissue. Anti-StreptInCor antibodies were able to neutralize/opsonize at least 5 strains, showing that immunization with StreptInCor is effective against several S. pyogenes strains and can prevent infection and subsequent sequelae without causing autoimmune reactions.

  14. Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA: e1004303

    National Research Council Canada - National Science Library

    Chris Neale; Nilmadhab Chakrabarti; Pawel Pomorski; Emil F Pai; Régis Pomès

    2015-01-01

    ...+ into cells, we examine early events in the relaxation of Mg2+ channel CorA toward its open state using massively-repeated molecular dynamics simulations conducted either with or without regulatory ions...

  15. Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA

    National Research Council Canada - National Science Library

    Neale, Chris; Chakrabarti, Nilmadhab; Pomorski, Pawel; Pai, Emil F; Pomès, Régis

    2015-01-01

    ...+ into cells, we examine early events in the relaxation of Mg2+ channel CorA toward its open state using massively-repeated molecular dynamics simulations conducted either with or without regulatory ions...

  16. Clinical Study in Treatment of Chronic Pulmonale Heart Failure with Shenmai Injection and Meglumine Adenosine Cyclophsphate Injection%参麦注射液联合环磷腺苷葡胺注射液治疗慢性肺源性心脏病心力衰竭临床研究

    Institute of Scientific and Technical Information of China (English)

    刘青如; 王永

    2011-01-01

    Objective:To explore the clinical curative effect of shenmai injection and meglumine adenosine cyclophsphate(MAC) injection in chronic pulmonary heart disease (i.e.cor pulmonale) heart failure(HF).Methods:Patients with cor pulmonale HF (n=120) were randomly divides into the treatment group(n=60) and the comparison group(n=60),Two groups in age, sex, clinical symptoms and signs, cardiac function,blood gas analysis,blood rheology, and complications such as the difference was not statistically significant(P>0.05).Two groups were given oxygen,expectorant, antispasmodic,asthma,anti-inflammatory,diuretics,vasodilators, to correct fluid and electrolyte disorders and acidbase balance disorders and other conventional treatment. At the same time,the treatment group was addsed shenmai injection 50 ml plus 5% GS 250 ml intravenous drip,qd,MAC injection 120 mg plus 5% GS 250 ml intravenous drip,qd, 14 days for a course of treatment. Results: The treatment group compared with the comparison group,After treatment, arterial carbon dioxide partial pressure, high shear viscosity, the shear viscosity, low shear viscosity, erythrocyte aggregation,hematocrit,fibrinogen decreased,blood pressure, pH value was increased,NYHA cardiac function classification improved, the differences were statistically significant (P<0.01).The total effective rate in the treatment group 95.0%(57/60) with the comparison group 73.3%(44/60) compared to significantly (P<0.01).Conclusion:shenmai injection and MAC injection treats cor pulmonale HF to may shorten the course,improve the cure rate improved,longer and better quality of life. Have a significant effect,saf e,reliable,quick,short duration of drug side effects and many other advantages,is worthy of clinical application.%目的:探讨参麦注射液联合环磷腺苷葡胺(MAC)注射液治疗慢性肺源性心脏病(简称肺心病)心力衰竭(HF)的临床疗效.方法:将120例肺心病HF患者随机分为治疗组(n=60)和对照组(n=60

  17. Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation.

    Science.gov (United States)

    Pfoh, Roland; Li, Angela; Chakrabarti, Nilmadhab; Payandeh, Jian; Pomès, Régis; Pai, Emil F

    2012-11-13

    Magnesium ions (Mg(2+)) are essential for life, but the mechanisms regulating their transport into and out of cells remain poorly understood. The CorA-Mrs2-Alr1 superfamily of Mg(2+) channels represents the most prevalent group of proteins enabling Mg(2+) ions to cross membranes. Thermotoga maritima CorA (TmCorA) is the only member of this protein family whose complete 3D fold is known. Here, we report the crystal structure of a mutant in the presence and absence of divalent ions and compare it with previous divalent ion-bound TmCorA structures. With Mg(2+) present, this structure shows binding of a hydrated Mg(2+) ion to the periplasmic Gly-Met-Asn (GMN) motif, revealing clues of ion selectivity in this unique channel family. In the absence of Mg(2+), TmCorA displays an unexpected asymmetric conformation caused by radial and lateral tilts of protomers that leads to bending of the central, pore-lining helix. Molecular dynamics simulations support these movements, including a bell-like deflection. Mass spectrometric analysis confirms that major proteolytic cleavage occurs within a region that is selectively exposed by such a bell-like bending motion. Our results point to a sequential allosteric model of regulation, where intracellular Mg(2+) binding locks TmCorA in a symmetric, transport-incompetent conformation and loss of intracellular Mg(2+) causes an asymmetric, potentially influx-competent conformation of the channel.

  18. Crystallization and preliminary X-ray diffraction analysis of the magnesium transporter CorA.

    Science.gov (United States)

    Payandeh, Jian; Pai, Emil F

    2006-02-01

    The full-length integral membrane protein CorA from Thermotoga maritima (TmCorA(1-351)) has been expressed in Escherichia coli and purified without membrane isolation. TmCorA(1-351) crystallized in the monoclinic space group C2, with unit-cell parameters a = 214.25, b = 86.30, c = 181.53 A, beta = 112.23 degrees. Native crystals diffracted to 3.7 A using synchrotron radiation, but selenomethionine-substituted crystals rarely diffracted to better than 5.0 A. All full-length protein crystals were highly mosaic and produced anisotropic diffraction patterns. To aid in crystallographic phasing, soluble domain constructs were screened and the periplasmic domain of CorA from Archaeoglobus fulgidus (AfCorA(1-263)) was crystallized in the hexagonal space group P6(1)22, with unit-cell parameters a = b = 101.17, c = 142.87 A. Native and SeMet-substituted AfCorA(1-263) crystals diffracted to approximately 3.0 A using synchrotron radiation.

  19. Corrigendum to "The 3-D strain patterns in Turkey using geodetic velocity fields from the RTK-CORS (TR) network" [J. African Earth Sci. 115 (2016) 246-270

    Science.gov (United States)

    Kutoglu, Hakan Senol; Toker, Mustafa; Mekik, Cetin

    2016-12-01

    In the article titled "The 3-D Strain patterns in Turkey using Geodetic velocity fields from the RTK-CORS (TR) Network" published in Journal of African Earth Sciences Vol. 11, pp.246-270, the black arrows on the Figs. 10 and 12 are shifted due to printing error to undesired places. The correct form of Figs. 10 and 12 are given below:

  20. Leishmania major CorA-like magnesium transporters play a critical role in parasite development and virulence.

    Science.gov (United States)

    Zhu, Ying; Davis, Antony; Smith, Brian J; Curtis, Joan; Handman, Emanuela

    2009-05-01

    Establishment of infection by Leishmania depends on the transformation of the invading metacyclic promastigotes into the obligatory intracellular amastigotes, and their subsequent survival in the macrophage phagolysosome, which is low in magnesium. We show that two Leishmania major proteins designated MGT1 and MGT2, which play a critical role in these processes, belong to the two-transmembrane domain (2-TM-GxN) cation transporter family and share homology with the major bacterial magnesium transporter CorA. Although both are present in the endoplasmic reticulum throughout the life cycle of the parasite, MGT1 is more highly expressed in the infectious metacyclic parasites, while MGT2 is enriched in the immature procyclic stages. The two proteins, although predicted to be structurally similar, have features that suggest different regulatory or gating mechanisms. The two proteins may also be functionally distinct, since only MGT1 complements an Escherichia coli DeltaCorA mutant. In addition, deletion of one mgt1 allele from L. major led to increased virulence, while deletion of one allele of mgt2 resulted in slower growth and total loss of virulence in vitro and in vivo. This loss of virulence may be due to an impaired transformation of the parasites into amastigotes. Deletion of both mgt1 alleles in the hemizygous MGT2 knockdown parasites reversed the growth defect and partially restored virulence. Our data indicate that the MGTs play a critical role in parasite growth, development and virulence.

  1. CorE from Myxococcus xanthus Is a Copper-Dependent RNA Polymerase Sigma Factor

    Science.gov (United States)

    Gómez-Santos, Nuria; Pérez, Juana; Sánchez-Sutil, María Celestina; Moraleda-Muñoz, Aurelio; Muñoz-Dorado, José

    2011-01-01

    The dual toxicity/essentiality of copper forces cells to maintain a tightly regulated homeostasis for this metal in all living organisms, from bacteria to humans. Consequently, many genes have previously been reported to participate in copper detoxification in bacteria. Myxococcus xanthus, a prokaryote, encodes many proteins involved in copper homeostasis that are differentially regulated by this metal. A σ factor of the ECF (extracytoplasmic function) family, CorE, has been found to regulate the expression of the multicopper oxidase cuoB, the P1B-type ATPases copA and copB, and a gene encoding a protein with a heavy-metal-associated domain. Characterization of CorE has revealed that it requires copper to bind DNA in vitro. Genes regulated by CorE exhibit a characteristic expression profile, with a peak at 2 h after copper addition. Expression rapidly decreases thereafter to basal levels, although the metal is still present in the medium, indicating that the activity of CorE is modulated by a process of activation and inactivation. The use of monovalent and divalent metals to mimic Cu(I) and Cu(II), respectively, and of additives that favor the formation of the two redox states of this metal, has revealed that CorE is activated by Cu(II) and inactivated by Cu(I). The activation/inactivation properties of CorE reside in a Cys-rich domain located at the C terminus of the protein. Point mutations at these residues have allowed the identification of several Cys involved in the activation and inactivation of CorE. Based on these data, along with comparative genomic studies, a new group of ECF σ factors is proposed, which not only clearly differs mechanistically from the other σ factors so far characterized, but also from other metal regulators. PMID:21655090

  2. CorE from Myxococcus xanthus is a copper-dependent RNA polymerase sigma factor.

    Directory of Open Access Journals (Sweden)

    Nuria Gómez-Santos

    2011-06-01

    Full Text Available The dual toxicity/essentiality of copper forces cells to maintain a tightly regulated homeostasis for this metal in all living organisms, from bacteria to humans. Consequently, many genes have previously been reported to participate in copper detoxification in bacteria. Myxococcus xanthus, a prokaryote, encodes many proteins involved in copper homeostasis that are differentially regulated by this metal. A σ factor of the ECF (extracytoplasmic function family, CorE, has been found to regulate the expression of the multicopper oxidase cuoB, the P1B-type ATPases copA and copB, and a gene encoding a protein with a heavy-metal-associated domain. Characterization of CorE has revealed that it requires copper to bind DNA in vitro. Genes regulated by CorE exhibit a characteristic expression profile, with a peak at 2 h after copper addition. Expression rapidly decreases thereafter to basal levels, although the metal is still present in the medium, indicating that the activity of CorE is modulated by a process of activation and inactivation. The use of monovalent and divalent metals to mimic Cu(I and Cu(II, respectively, and of additives that favor the formation of the two redox states of this metal, has revealed that CorE is activated by Cu(II and inactivated by Cu(I. The activation/inactivation properties of CorE reside in a Cys-rich domain located at the C terminus of the protein. Point mutations at these residues have allowed the identification of several Cys involved in the activation and inactivation of CorE. Based on these data, along with comparative genomic studies, a new group of ECF σ factors is proposed, which not only clearly differs mechanistically from the other σ factors so far characterized, but also from other metal regulators.

  3. Initial binding of ions to the interhelical loops of divalent ion transporter CorA: replica exchange molecular dynamics simulation study.

    Directory of Open Access Journals (Sweden)

    Tong Zhang

    Full Text Available Crystal structures of Thermotoga maritima magnesium transporter CorA, reported in 2006, revealed its homo-pentameric constructions. However, the structure of the highly conserved extracellular interhelical loops remains unsolved, due to its high flexibility. We have explored the configurations of the loops through extensive replica exchange molecular dynamics simulations in explicit solvent model with the presence of either Co(III Hexamine ions or Mg(2+ ions. We found that there are multiple binding sites available on the interhelical loops in which the negatively charged residues, E316 and E320, are located notably close to the positively charged ions during the simulations. Our simulations resolved the distinct binding patterns of the two kinds of ions: Co(III Hexamine ions were found to bind stronger with the loop than Mg(2+ ions with binding free energy -7.3 kJ/mol lower, which is nicely consistent with the previous data. Our study provides an atomic basis description of the initial binding process of Mg(2+ ions on the extracellular interhelical loops of CorA and the detailed inhibition mechanism of Co(III Hexamine ions on CorA ions transportation.

  4. Initial binding of ions to the interhelical loops of divalent ion transporter CorA: replica exchange molecular dynamics simulation study.

    Science.gov (United States)

    Zhang, Tong; Mu, Yuguang

    2012-01-01

    Crystal structures of Thermotoga maritima magnesium transporter CorA, reported in 2006, revealed its homo-pentameric constructions. However, the structure of the highly conserved extracellular interhelical loops remains unsolved, due to its high flexibility. We have explored the configurations of the loops through extensive replica exchange molecular dynamics simulations in explicit solvent model with the presence of either Co(III) Hexamine ions or Mg(2+) ions. We found that there are multiple binding sites available on the interhelical loops in which the negatively charged residues, E316 and E320, are located notably close to the positively charged ions during the simulations. Our simulations resolved the distinct binding patterns of the two kinds of ions: Co(III) Hexamine ions were found to bind stronger with the loop than Mg(2+) ions with binding free energy -7.3 kJ/mol lower, which is nicely consistent with the previous data. Our study provides an atomic basis description of the initial binding process of Mg(2+) ions on the extracellular interhelical loops of CorA and the detailed inhibition mechanism of Co(III) Hexamine ions on CorA ions transportation.

  5. Regulation of CorA Mg2+ channel function affects the virulence of Salmonella enterica serovar typhimurium.

    Science.gov (United States)

    Papp-Wallace, Krisztina M; Maguire, Michael E

    2008-10-01

    The CorA Mg(2+) channel is the primary source of intracellular Mg(2+) in Salmonella enterica serovar Typhimurium. In another study, we found that a strain lacking corA was attenuated in mice and also defective for invasion and replication within Caco-2 epithelial cells (K. M. Papp-Wallace, M. Nartea, D. G. Kehres, S. Porwollik, M. McClelland, S. J. Libby, F. C. Fang, and M. E. Maguire, J. Bacteriol. 190:6517-6523, 2008). Therefore, we further examined Salmonella interaction with Caco-2 epithelial cells. Inhibiting CorA acutely or chronically with a high concentration of a selective inhibitor, Co(III) hexaammine, had no effect on S. enterica serovar Typhimurium invasion of Caco-2 epithelial cells. Complementing the corA mutation with corA from various species rescued the invasion defect only if the complementing allele was functional and if it was evolutionarily similar to S. enterica serovar Typhimurium CorA. One explanation for these results could be that regulation of CorA function is needed for optimal virulence. Further experiments examining corA transcription, CorA protein content, CorA transport, and cell Mg(2+) content indicated that both CorA expression and CorA function are differentially regulated. Moreover, the rates of Mg(2+) influx via CorA are not closely correlated with either protein levels or Mg(2+) content. We conclude that loss of the CorA protein disrupts a regulatory network(s) with the ultimate phenotype of decreased virulence. This conclusion is compatible with the microarray results in our other study, which showed that loss of corA resulted in changes in transcription (and protein expression) in multiple metabolic pathways (Papp-Wallace et al., J. Bacteriol. 190:6517-6523, 2008). Further study of the regulation of CorA expression and function provides an opportunity to dissect the complexity of Mg(2+) homeostasis and its ties to virulence within the bacterium.

  6. Multi-viewpoint Coronal Mass Ejection Catalog Based on STEREO COR2 Observations

    Science.gov (United States)

    Vourlidas, Angelos; Balmaceda, Laura A.; Stenborg, Guillermo; Dal Lago, Alisson

    2017-04-01

    We present the first multi-viewpoint coronal mass ejection (CME) catalog. The events are identified visually in simultaneous total brightness observations from the twin SECCHI/COR2 coronagraphs on board the Solar Terrestrial Relations Observatory mission. The Multi-View CME Catalog differs from past catalogs in three key aspects: (1) all events between the two viewpoints are cross-linked, (2) each event is assigned a physics-motivated morphological classification (e.g., jet, wave, and flux rope), and (3) kinematic and geometric information is extracted semi-automatically via a supervised image segmentation algorithm. The database extends from the beginning of the COR2 synoptic program (2007 March) to the end of dual-viewpoint observations (2014 September). It contains 4473 unique events with 3358 events identified in both COR2s. Kinematic properties exist currently for 1747 events (26% of COR2-A events and 17% of COR2-B events). We examine several issues, made possible by this cross-linked CME database, including the role of projection on the perceived morphology of events, the missing CME rate, the existence of cool material in CMEs, the solar cycle dependence on CME rate, speeds and width, and the existence of flux rope within CMEs. We discuss the implications for past single-viewpoint studies and for Space Weather research. The database is publicly available on the web including all available measurements. We hope that it will become a useful resource for the community.

  7. The structure of CorA: a Mg(2+)-selective channel.

    Science.gov (United States)

    Maguire, Michael E

    2006-08-01

    The crystal structure of a closed form of the CorA Mg2+ transporter from Thermatoga maritima completes a set of representative structures of transport systems for all of the major biological elements, Mg2+, Ca2+, Na+, K+ and Cl-. The CorA monomer has a C-terminal membrane domain containing two transmembrane segments and a large N-terminal cytoplasmic soluble domain. In the membrane, CorA forms a homopentamer shaped like a funnel. Comparison of the structure of CorA with that of other ion channels and transporters suggests numerous common features, but, as might be predicted from the unique chemistry of the Mg2+ cation, the structure of CorA has several unusual features. Among these are initial binding in the periplasm of a fully hydrated Mg2+ ion; a ring of positive charge external to the ion-conduction pathway at the cytosolic membrane interface; and highly negatively charged helices in the cytosolic domain that appear capable of interacting with the ring of positive charge to facilitate Mg2+ entry. Finally, there are bound Mg2+ ions in the cytosolic domain that are well placed to control the interaction of the ring of positive charge and the negatively charged helices, and thus control Mg2+ entry.

  8. [Silver-Russell syndrome (hemihypertrophy) and cor triatriatum in a newborn].

    Science.gov (United States)

    Ríos-Méndez, Raúl Enrique; Montero-Monar, Hernán Eduardo; Pernández-Alvarado, Antonio Pedro; Hidalgo-Flores, Einstein Gustavo

    2015-06-01

    Hemihypertrophy syndrome and cor triatriatum are extremely rare pathologies. Hemihypertrophy is defined as complete or partial overgrowth of one of the hemibodies. Cor triatriatum is a congenital heart disease characterized by a membrane which separates the left atrium into two chambers; if that membrane has a restrictive hole, it causes obstruction to blood passage from the pulmonary veins into the left ventricle causing hypertension and pulmonary edema. In this context, the patent ductus arteriosus can act as a means of decompression of the pulmonary circuit, because it allows the blood passage from the pulmonary artery to the aorta. We report a patient with Silver-Rusell syndrome (hemihypertrophy), cor triatriatum and ductus arteriosus with reverse flow. To our knowledge, this association of rare pathologies and this clinical presentation have not been described previously.

  9. Contradictions within a Knotworking session of an interior décor project

    DEFF Research Database (Denmark)

    Rasmussen, Mai; Jensen, Rasmus Lund; Fisker, Anna Marie;

    actors with an interest in the specific ‘knot’ (Engeström 2008). Moreover this presentation presents an analysis of contradictions within a Knotworking session of an interior décor project. The interior décor project is targeted a new building for Department of Civil Engineering at Aalborg University...... in Denmark aiming to generate an ownership among the users of the building. Through this presentation the audience will discover advantages and disadvantages of the utilization of Knotowkring as a method for making interior décor at a Danish University. Moreover, the audience will notify Knotworking...... as a method for dealing with collaboration. This presentation is targeted researchers working with collaboration among actors with various historical backgrounds and researchers with an interest in Knotworking. The research will contribute to a novel context for utilizing Knotworking, which previously has...

  10. SkipCor: skip-mention coreference resolution using linear-chain conditional random fields.

    Directory of Open Access Journals (Sweden)

    Slavko Žitnik

    Full Text Available Coreference resolution tries to identify all expressions (called mentions in observed text that refer to the same entity. Beside entity extraction and relation extraction, it represents one of the three complementary tasks in Information Extraction. In this paper we describe a novel coreference resolution system SkipCor that reformulates the problem as a sequence labeling task. None of the existing supervised, unsupervised, pairwise or sequence-based models are similar to our approach, which only uses linear-chain conditional random fields and supports high scalability with fast model training and inference, and a straightforward parallelization. We evaluate the proposed system against the ACE 2004, CoNLL 2012 and SemEval 2010 benchmark datasets. SkipCor clearly outperforms two baseline systems that detect coreferentiality using the same features as SkipCor. The obtained results are at least comparable to the current state-of-the-art in coreference resolution.

  11. Not all resources are created equal: COR theory, values, and stress.

    Science.gov (United States)

    Morelli, Neil A; Cunningham, Christopher J L

    2012-01-01

    The common usage of conservation of resources (COR) theory highlights the quantity of resources in explaining stress reactions and responses. To expand the theoretical understanding and explanatory power of COR theory, this study tested the proposition that the perceived importance of an individual's resources is a function of personal values. Using a value framework based on Schwartz (1994), it was expected that values would influence both the appraisal of resource importance and coping behaviors. Results from both student and working samples indicated that while resource importance did not clearly mediate all of the coping outcomes, values did have an influence on the importance an individual assigns to resources. Measurement and theoretical implications related to COR theory are discussed.

  12. NASA Astrophysics Cosmic Origins (COR) and Physics of the Cosmos (PCOS) Strategic Technology Development Program

    Science.gov (United States)

    Pham, Thai; Seery, Bernard D.

    2015-01-01

    The COR and PCOS Program Offices (PO) reside at the NASA Goddard Space Flight Center (GSFC), serving as the NASA Astrophysics Division's implementation arm for matters relating to the two programs. One aspect of the PO's activities is managing the COR and PCOS Strategic Astrophysics Technology (SAT) program, helping mature technologies to enable and enhance future astrophysics missions.The PO is guided by the National Research Council's 'New Worlds, New Horizons in Astronomy and Astrophysics' Decadal Survey report, and NASA's Astrophysics Implementation Plan. Strategic goals include dark energy; gravitational waves; X-ray observatories, e.g., US participation in ATHENA; Inflation probe; and a large UV/Visible telescope.To date, 51 COR and 65 PCOS SAT proposals have been received, of which 11 COR and 18 PCOS projects were funded. Notable successes include maturation of a new far-IR detector, later adopted by the SOFIA HAWC instrument; maturation of the H4RG near-IR detector, adopted by WFIRST; development of an antenna-coupled transition-edge superconducting bolometer, a technology deployed by BICEP2 that allowed measurement of B-mode polarization in the CMB signal, a possible signature of Inflation; and finally, the REXIS instrument on OSIRIS-REx is incorporating CCDs with directly deposited optical blocking filters developed by another SAT-funded project.We discuss our technology development process, with community input and strategic prioritization informing calls for SAT proposals and guiding investment decisions. We also present results of this year's technology gap prioritization and showcase our current portfolio of technology development projects. These include five newly selected projects, kicking off in FY 2015.For more information, visit the COR Program website at cor.gsfc.nasa.gov and the PCOS website at pcos.gsfc.nasa.gov.

  13. Combining STEREO SECCHI COR2 and HI1 images for automatic CME front edge tracking

    Directory of Open Access Journals (Sweden)

    Kirnosov Vladimir

    2016-01-01

    Full Text Available COR2 coronagraph images are the most commonly used data for coronal mass ejection (CME analysis among the various types of data provided by the STEREO (Solar Terrestrial Relations Observatory SECCHI (Sun-Earth Connection Coronal and Heliospheric Investigation suite of instruments. The field of view (FOV in COR2 images covers 2–15 solar radii (Rs that allow for tracking the front edge of a CME in its initial stage to forecast the lead-time of a CME and its chances of reaching the Earth. However, estimating the lead-time of a CME using COR2 images gives a larger lead-time, which may be associated with greater uncertainty. To reduce this uncertainty, CME front edge tracking should be continued beyond the FOV of COR2 images. Therefore, heliospheric imager (HI1 data that covers 15–90 Rs FOV must be included. In this paper, we propose a novel automatic method that takes both COR2 and HI1 images into account and combine the results to track the front edges of a CME continuously. The method consists of two modules: pre-processing and tracking. The pre-processing module produces a set of segmented images, which contain the signature of a CME, for both COR2 and HI1 separately. In addition, the HI1 images are resized and padded, so that the center of the Sun is the central coordinate of the resized HI1 images. The resulting COR2 and HI1 image set is then fed into the tracking module to estimate the position angle (PA and track the front edge of a CME. The detected front edge is then used to produce a height-time profile that is used to estimate the speed of a CME. The method was validated using 15 CME events observed in the period from January 1, 2008 to August 31, 2009. The results demonstrate that the proposed method is effective for CME front edge tracking in both COR2 and HI1 images. Using this method, the CME front edge can now be tracked automatically and continuously in a much larger range, i.e., from 2 to 90 Rs, for the first time. These

  14. Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

    OpenAIRE

    Gabriela Soncini Pasetto; Henrique Pedroso de Freitas; Carina Graziottin Colossi; Manuel Augusto Pereira Vilela

    2013-01-01

    OBJETIVO: Avaliar, retrospectivamente, num longo intervalo de tempo, os resultados da termoterapia transpupilar em casos selecionados do melanoma de coróide. MÉTODOS: Foram identificados todos os casos com melanoma de coróide tratados com termoterapia transpupilar, como terapia única ou suplementar. Foram excluídos os casos com seguimento inferior a 60 meses, prontuários incompletos ou com o abandono do acompanhamento. RESULTADOS: De um total de 18 olhos, 7 (38.9%) foram incluídos no estudo. ...

  15. Carcinoma bilateral do plexo coróide operado com sucesso

    Directory of Open Access Journals (Sweden)

    Gilberto M. de Almeida

    1970-06-01

    Full Text Available Os autores não encontraram na literatura caso de carcinoma bilateral do plexo coróide operado com sucesso. O trabalho consta da apresentação de uma criança de 11 anos com carcinoma dos plexos coróides nos dois ventrículos laterais. São feitas considerações a respeito das dificuldades no diagnóstico, da importância dó estudo angiográfico completo e do tratamento

  16. 浅谈 CORS 站观测墩高量测方法%Research on Measurement Method of CORS Observation Post Height

    Institute of Scientific and Technical Information of China (English)

    仇国军

    2015-01-01

    目前,利用多基站网络 RTK技术建立的连续运行卫星定位服务综合系统( Continuous Operational Refer-ence System,缩写为CORS)已成为各省GPS应用的发展重点。 CORS系统是卫星定位技术、计算机网络技术、数字通讯技术等高新科技多方位、深度的产物。观测墩高度的测量精度将直接影响CORS站系统高程精度,本文结合LNCORS站观测墩高测量方法及在准备阶段研究成果,阐述CORS站观测墩高测量方法及精度分析。%With the rapid progress and wide popularity of GPS Technology, it plays an important role in measurement.At present, based on RTK Technology, Continuous Operational Reference System, CORS was set up, it has become development focus of GPS ap-plication in every province.CORS is a multi-azimuth product of Satellite Positioning Technology, Computer Network Technology, Digital Communication Technology and other high technologies.Measurement accuracy of observation post height will directly affect CORS height accuracy.The paper is based on LNCORS observation post height measurement method and preliminary research results, expound CORS observation post height measurement method as well as precise analysis.

  17. Indoor Spatial Monitoring of Combustion Generated Pollutants (TSP, CO, and BaP) by Indian Cookstoves

    Science.gov (United States)

    1988-07-01

    Woolcock, 1967, attributed a prevalence of chronic bronchitis and cor pulmonale among the highlanders in Papua New Guinea (PNG). Sofoluwe, 1968 reported high...clinical examination of about 1800 heart patients in Nepal, reported high incidence of cor pulmonale and pointed at cigarette smoking and exposure to...Study of chronic cor pulmonale Pad- (heart disease secondary to mavati lung disease) in Delhi between and 1958-1974. Conclusion: Among Arora, women

  18. Cardiopulmonary Aspects in Aerospace Medicine (Les Aspects Cardiopulmonaires en Medecine Aerospatiale)

    Science.gov (United States)

    1993-10-01

    atrium. Individuals with mitral stenosis or cor 10 min.) SVT. In all, 42 (10%) had symptoms of pulmonale with atrial enlargement have frequent...often development of emphysema. (The commoner slight till the onset of cor pulmonale , that is failure heterozygous form of the disorder rarely causes...remissions cor pulmonale Whether bronchial hyper-reactivity plays a part in is usually fatal within a few years, individual predisposition to COPD has long

  19. The Acquisition of Perceptual Diagnostic Skill in Radiology.

    Science.gov (United States)

    1981-09-14

    presence of right ventricular hypertrophy and right heart failure ( cor pulmonale ) which often (but not necessarily) accompany COPD and emphysema. A...representation of COPD constructed by the subject for the film included cor pulmonale (right heart failure) which carries even greater commitment to...supply blood. Usually associated with blood stagnation. COPD - see Chronic Obstructive Pulmonary Disease cor pulmonale - heart disease secondary to disease

  20. Ligand binding in the conserved interhelical loop of CorA, a magnesium transporter from Mycobacterium tuberculosis.

    Science.gov (United States)

    Hu, Jian; Sharma, Mukesh; Qin, Huajun; Gao, Fei Philip; Cross, Timothy A

    2009-06-05

    CorA is a constitutively expressed magnesium transporter in many bacteria. The crystal structures of Thermotoga maritima CorA provide an excellent structural framework for continuing studies. Here, the ligand binding properties of the conserved interhelical loop, the only portion of the protein exposed to the periplasmic space, are characterized by solution nuclear magnetic resonance spectroscopy. Through titration experiments performed on the isolated transmembrane domain of Mycobacterium tuberculosis CorA, it was found that two CorA substrates (Mg2+ and Co2+) and the CorA-specific inhibitor (Co(III) hexamine chloride) bind in the loop at the same binding site. This site includes the glutamic acid residue from the conserved "MPEL" motif. The relatively large dissociation constants indicate that such interactions are weak but not atypical for channels. The present data support the hypothesis that the negatively charged loop could act as an electrostatic ring, increasing local substrate concentrations before transport across the membrane.

  1. The importance of risk models for management of pulmonary nodules; Die Bedeutung von Risikomodellen fuer das Management pulmonaler Rundherde

    Energy Technology Data Exchange (ETDEWEB)

    Prosch, H.; Baltzer, P. [Medizinische Universitaet Wien, Allgemeines Krankenhaus, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Wien (Austria)

    2014-05-15

    Pulmonary nodules are a frequent finding in computed tomography (CT) investigations. Further diagnostic work-up of detected nodules mainly depends on the so-called pre-test probability, i.e. the probability that the nodule is malignant or benign. The pre-test probability can be calculated by combining all relevant information, such as the age and the sex of the patient, the smoking history, and history of previous malignancies, as well as the size and CT morphology of the nodule. If additional investigations are performed to further investigate the nodules, all results must be interpreted taking into account the pre-test probability and the test performance of the investigation in order to estimate the post-test probability. In cases with a low pre-test probability, a negative result from an exact test can exclude malignancies but a positive test cannot prove malignancy in such a setting. In cases with a high pre-test probability, a positive test result can be considered as proof of malignancy but a negative test result does not exclude malignancy. (orig.) [German] Pulmonale Rundherde sind ein haeufiger Befund bei CT-Untersuchungen des Thorax. Die weiterfuehrende Abklaerung der gefunden Rundherde haengt im Wesentlichen von der so genannten Vortestwahrscheinlichkeit ab, der Wahrscheinlichkeit ob der Rundherd maligne ist oder nicht. Diese Vortestwahrscheinlichkeit laesst sich durch die Kombination aller relevanten Vorinformationen wie Alter und Geschlecht des Patienten, Raucheranamnese, Tumoranamnese, Groesse und CT-Morphologie des Rundherdes genau berechnen oder intuitiv abschaetzen. Werden weiterfuehrende Untersuchungen zur Abklaerung des Rundherdes durchgefuehrt, ist das Ergebnis dieser Untersuchung, die Nachtestwahrscheinlichkeit fuer das Vorliegen von Malignitaet, in Abhaengigkeit von der Vortestwahrscheinlichkeit und der Testguete der Untersuchung zu interpretieren. Waehrend ein genauer Test im Falle niedriger Vortestwahrscheinlichkeiten Malignitaet mit

  2. Impact of Maillard Reaction on Immunoreactivity and Allergenicity of the Hazelnut Allergen Cor a 11

    NARCIS (Netherlands)

    Iwan, M.; Vissers, Y.M.; Fiedorowicz, E.; Kostyra, H.; Savelkoul, H.F.J.; Wichers, H.J.

    2011-01-01

    Few studies exist on the influence of processing methods on structural changes and allergenic potential of hazelnut proteins. This study focused on the effect of glycation (Maillard reaction) on the immunoreactivity and degranulation capacity of the purified hazelnut 7S globulin, Cor a 11. After hea

  3. Variability of Corylus avellana, L. CorA and profilin pollen allergens expression.

    Science.gov (United States)

    Ražná, Katarína; Bežo, Milan; Nikolaieva, Natalia; Garkava, Katerina; Brindza, Ján; Ziarovská, Jana

    2014-01-01

    Corylus avellana is the source of inhalant allergies induced by hazel pollen as well as food allergies induced after ingestion of hazelnuts. In this study, real-time PCR approach was used to analyse expression of hazel pollen allergens on the molecular level. Relative quantity of hazelnut allergens Corylus avellana, L. CorA and Corylus avellana, L. pollen profiling in samples from different Ukraine areas were determining and comparing. Differences among the levels of both analysed allergen transcripts were found for hazel CorA and profillin. In both cases, the expression within the urbanized growth conditions was higher when compared to the sample from village area. The average expression for CorA was 0.84 times higher than for profilin and the results are very variable depending on the place of growth. Expression levels here were within the range of 2.957 up to the 52.936. Profilin expression was the highest in the sample from the polluted place of growth-cement plant area with the value of 52 times higher when compared to the sample from the village area. In this study, comparison of expression levels of hazel CorA and profiling pollen allergens was performed for the first time. Real-time PCR assay developed in this study proved the sensitivity for detection of the changes of the hazel pollen allergens expression levels and could benefit labs by fast and reproducible detection method of these allergens.

  4. Surprising Loss of Symmetry of Magnesium Channel CorA Upon Gating | Center for Cancer Research

    Science.gov (United States)

    Magnesium ions (Mg2+) play essential roles in all living organisms. Bacteria and other prokaryotes rely upon the Mg2+-dependent channel CorA, which is composed of five identical subunits (A-E), to obtain these ions from their surroundings.

  5. A repulsion mechanism explains magnesium permeation and selectivity in CorA.

    Science.gov (United States)

    Dalmas, Olivier; Sandtner, Walter; Medovoy, David; Frezza, Ludivine; Bezanilla, Francisco; Perozo, Eduardo

    2014-02-25

    Magnesium (Mg(2+)) plays a central role in biology, regulating the activity of many enzymes and stabilizing the structure of key macromolecules. In bacteria, CorA is the primary source of Mg(2+) uptake and is self-regulated by intracellular Mg(2+). Using a gating mutant at the divalent ion binding site, we were able to characterize CorA selectivity and permeation properties to both monovalent and divalent cations under perfused two-electrode voltage clamp. The present data demonstrate that under physiological conditions, CorA is a multioccupancy Mg(2+)-selective channel, fully excluding monovalent cations, and Ca(2+), whereas in absence of Mg(2+), CorA is essentially nonselective, displaying only mild preference against other divalents (Ca(2+) > Mn(2+) > Co(2+) > Mg(2+) > Ni(2)(+)). Selectivity against monovalent cations takes place via Mg(2+) binding at a high-affinity site, formed by the Gly-Met-Asn signature sequence (Gly312 and Asn314) at the extracellular side of the pore. This mechanism is reminiscent of repulsion models proposed for Ca(2+) channel selectivity despite differences in sequence and overall structure.

  6. Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating.

    Science.gov (United States)

    Matthies, Doreen; Dalmas, Olivier; Borgnia, Mario J; Dominik, Pawel K; Merk, Alan; Rao, Prashant; Reddy, Bharat G; Islam, Shahidul; Bartesaghi, Alberto; Perozo, Eduardo; Subramaniam, Sriram

    2016-02-11

    CorA, the major Mg(2+) uptake system in prokaryotes, is gated by intracellular Mg(2+) (KD ∼ 1-2 mM). X-ray crystallographic studies of CorA show similar conformations under Mg(2+)-bound and Mg(2+)-free conditions, but EPR spectroscopic studies reveal large Mg(2+)-driven quaternary conformational changes. Here, we determined cryo-EM structures of CorA in the Mg(2+)-bound closed conformation and in two open Mg(2+)-free states at resolutions of 3.8, 7.1, and 7.1 Å, respectively. In the absence of bound Mg(2+), four of the five subunits are displaced to variable extents (∼ 10-25 Å) by hinge-like motions as large as ∼ 35° at the stalk helix. The transition between a single 5-fold symmetric closed state and an ensemble of low Mg(2+), open, asymmetric conformational states is, thus, the key structural signature of CorA gating. This mechanism is likely to apply to other structurally similar divalent ion channels. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Structural insights into the mechanisms of Mg2+ uptake, transport, and gating by CorA.

    Science.gov (United States)

    Guskov, Albert; Nordin, Nurhuda; Reynaud, Aline; Engman, Henrik; Lundbäck, Anna-Karin; Jong, Agnes Jin Oi; Cornvik, Tobias; Phua, Terri; Eshaghi, Said

    2012-11-06

    Despite the importance of Mg(2+) for numerous cellular activities, the mechanisms underlying its import and homeostasis are poorly understood. The CorA family is ubiquitous and is primarily responsible for Mg(2+) transport. However, the key questions-such as, the ion selectivity, the transport pathway, and the gating mechanism-have remained unanswered for this protein family. We present a 3.2 Å resolution structure of the archaeal CorA from Methanocaldococcus jannaschii, which is a unique complete structure of a CorA protein and reveals the organization of the selectivity filter, which is composed of the signature motif of this family. The structure reveals that polar residues facing the channel coordinate a partially hydrated Mg(2+) during the transport. Based on these findings, we propose a unique gating mechanism involving a helical turn upon the binding of Mg(2+) to the regulatory intracellular binding sites, and thus converting a polar ion passage into a narrow hydrophobic pore. Because the amino acids involved in the uptake, transport, and gating are all conserved within the entire CorA family, we believe this mechanism is general for the whole family including the eukaryotic homologs.

  8. Molecular mechanism of Mg2+-dependent gating in CorA

    Science.gov (United States)

    Dalmas, Olivier; Sompornpisut, Pornthep; Bezanilla, Francisco; Perozo, Eduardo

    2014-04-01

    CorA is the major transport system responsible for Mg2+ uptake in bacteria and can functionally substitute for its homologue Mrs2p in the yeast inner mitochondrial membrane. Although several CorA crystal structures are available, the molecular mechanism of Mg2+ uptake remains to be established. Here we use electron paramagnetic resonance spectroscopy, electrophysiology and molecular dynamic simulations to show that CorA is regulated by cytoplasmic Mg2+ acting as a ligand and elucidate the basic conformational rearrangements responsible for Mg2+-dependent gating. Mg2+ unbinding at the divalent cation sensor triggers a conformational change that leads to the inward motion of the stalk helix, which propagates to the pore-forming transmembrane helix TM1. Helical tilting and rotation in TM1 generates an iris-like motion that increases the diameter of the permeation pathway, triggering ion conduction. This work establishes the molecular basis of a Mg2+-driven negative feedback loop in CorA as the key physiological event controlling Mg2+ uptake and homeostasis in prokaryotes.

  9. A imagem e a cor no Tratado de Hume: elementos de ontologia política

    Directory of Open Access Journals (Sweden)

    Cesar Kiraly

    2011-12-01

    Full Text Available Neste ensaio investigo a imagem e a cor no Tratado de Hume, de modo a relacionar com a instituição, em oposição à constituição.In this essay I inquiry the image and the color in Hume's Treatise, in the way to relate with the institution, in opposition to the constitution.

  10. The precise regulation of different COR genes by individual CBF transcription factors in Arabidopsis thaliana.

    Science.gov (United States)

    Shi, Yihao; Huang, Jiaying; Sun, Tianshu; Wang, Xuefei; Zhu, Chenqi; Ai, Yuxi; Gu, Hongya

    2017-02-01

    The transcription factors CBF1/2/3 are reported to play a dominant role in the cold responsive network of Arabidopsis by directly regulating the expression levels of cold responsive (COR) genes. In this study, we obtained CRISPR/Cas9-mediated loss-of-function mutants of cbf1∼3. Over 3,000 COR genes identified by RNA-seq analysis showed a slight but significant change in their expression levels in the mutants compared to the wild-type plants after being treated at 4 °C for 12 h. The C-repeat (CRT) motif (5'-CCGAC-3') was enriched in promoters of genes that were up-regulated by CBF2 and CBF3 but not in promoters of genes up-regulated by CBF1. These data suggest that CBF2 and CBF3 play a more important role in directing the cold response by regulating different sets of downstream COR genes. More than 2/3 of COR genes were co-regulated by two or three CBFs and were involved mainly in cellular signal transduction and metabolic processes; less than 1/3 of the genes were regulated by one CBF, and those genes up-regulated were enriched in cold-related abiotic stress responses. Our results indicate that CBFs play an important role in the trade-off between cold tolerance and plant growth through the precise regulation of COR genes in the complicated transcriptional network. © 2016 The Authors. Journal of Integrative Plant Biology Published by John Wiley & Sons Australia, Ltd on behalf of Institute of Botany, Chinese Academy of Sciences.

  11. Automatic near-real-time detection of CMEs in Mauna Loa K-Cor coronagraph images

    Science.gov (United States)

    Thompson, William T.; St. Cyr, Orville Chris; Burkepile, Joan; Posner, Arik

    2017-08-01

    A simple algorithm has been developed to detect the onset of coronal mass ejections (CMEs), together with an estimate of their speed, in near-real-time using images of the linearly polarized white-light solar corona taken by the K-Cor telescope at the Mauna Loa Solar Observatory (MLSO). The algorithm used is a variation on the Solar Eruptive Event Detection System (SEEDS) developed at George Mason University. The algorithm was tested against K-Cor data taken between 29 April 2014 and 20 February 2017, on days which the MLSO website marked as containing CMEs. This resulted in testing of 139 days worth of data containing 171 CMEs. The detection rate varied from close to 80% in 2014-2015 when solar activity was high, down to as low as 20-30% in 2017 when activity was low. The difference in effectiveness with solar cycle is attributed to the difference in relative prevalance of strong CMEs between active and quiet periods. There were also twelve false detections during this time period, leading to an average false detection rate of 8.6% on any given day. However, half of the false detections were clustered into two short periods of a few days each when special conditions prevailed to increase the false detection rate. The K-Cor data were also compared with major Solar Energetic Particle (SEP) storms during this time period. There were three SEP events detected either at Earth or at one of the two STEREO spacecraft where K-Cor was observing during the relevant time period. The K-Cor CME detection algorithm successfully generated alerts for two of these events, with lead times of 1-3 hours before the SEP onset at 1 AU. The third event was not detected by the automatic algorithm because of the unusually broad width of the CME in position angle.

  12. Radiological evaluation of treatment with SpineCor brace in children with idiopathic spinal scoliosis.

    Science.gov (United States)

    Plewka, Barbara; Sibiński, Marcin; Synder, Marek; Witoński, Dariusz; Kołodziejczyk-Klimek, Katarzyna; Plewka, Michał

    2013-06-28

    INTRODUCTION. This paper reports on a radiological evaluation of the outcomes of treatment with the SpineCor brace in children with idiopathic spinal scoliosis vs. a control group who had only received 24 months of rehabilitation. The compliance of the SpineCor-treated patients with medical instructions was also assessed. MATERIAL AND METHODS. A prospective evaluation encompassed a group of forty (40) children, treated with a SpineCor brace for idiopathic scoliosis. A control group included forty (40) children who were followed up. The mean age of the children was 12.0 years and sixty-six (66) of the patients were girls. The study group and the control group were comparable in terms of demographic data and radiological parameters of scoliosis. The mean scoliosis angle was 25.3˚ and 26.1˚ in the thoracic and lumbar spine, respectively. RESULTS. In the (SpineCor-treated) study group, stabilisation or improvement of the scoliosis was obtained in 31 (78%) patients, while progression was noted in 9 (22%). In the control group, stabilisation was found in 21 (53%) patients and progression in 19 (47%), while none of the children met improvement criteria. In the brace-treated group, a smaller change in the thoracic curvature angle was observed (R=0.34, p=0.0001) than in the control group, while no such difference was identified at the lumbar spine level (R=0.15, p=0.18). Out of the 40 treated children, 38 used the brace regularly. Four of the children were active in sports above recreation level. CONCLUSIONS. The treatment of idiopathic spinal scoliosis in children by means of the SpineCor dynamic brace solution significantly more frequently led to stabilisation or correction of scoliosis as measured by Cobb's angle. A high compliance of the children and their parents was also observed.

  13. Reanalysis of CORS and Global GPS Data at the National Geodetic Survey

    Science.gov (United States)

    Griffiths, J.; Rohde, J. R.; Ray, J.; Cline, M.; Dillinger, W. H.; Dulaney, R. L.; Hilla, S.; Kass, W. G.

    2008-12-01

    We present current results and preliminary interpretations from an ongoing project at the National Geodetic Survey (NGS) to reanalyze Global Positioning System (GPS) data collected since 1994 at stations of the International GNSS Service (IGS) global tracking network and at stations of the U.S. Continuously Operating Reference Stations (CORS) network. Reanalysis of the global data is expected to be complete by January 2009, while the reanalysis of the CORS data will take much longer, perhaps until late 2011. The reanalysis is accomplished in two stages. The first stage is designed to obtain a consistent set of GPS satellite orbits, Earth Rotation Parameters (ERPs) and a time series of global station coordinates expressed in the current IGS Terrestrial Reference Frame, i.e., IGS05. The second stage is designed to obtain a time- series of station coordinates for the much denser CORS network. An important aspect to this two-stage approach is that a relatively uniform global network is used to determine the satellite orbits, ERPs and terrestrial frame, which are then fixed and used to position the CORS network accurately and consistently within the same framework. Both stages of the analysis use a) the PAGES software from NGS to preprocess and reduce the RINEX observations, and b) the CATREF software from Institut Géographique National to obtain regularized station coordinates and secular velocities. The CATREF software provides the added benefit of allowing weekly Helmert frame alignments to the long-term frame and detection of station discontinuities and other frame distortions in both the global and CORS solutions.

  14. Interfaces et reconfigurations de la question Nord/Sud en Corée.

    Directory of Open Access Journals (Sweden)

    Valérie Gelézeau

    2010-12-01

    Full Text Available S’appuyant sur un travail pluridisciplinaire autour de la notion d’interface, l’article propose de nouvelles perspectives d’analyse de la question Nord/Sud en Corée en considérant la partition entre Corée du Nord et Corée du Sud non plus comme un simple contexte géopolitique mais comme une matrice structurante des deux sociétés. Trois grands types d’interfaces entre les deux Corées sont identifiés et analysés à travers plusieurs études de cas : les interfaces spatiales (la frontière inter-coréenne, la frontière sino-nord-coréenne, ou encore les enclaves économiques développées au Nord par la Corée du Sud, les interfaces sociales (la communauté des Nord-Coréens au Sud, les élites sud-coréennes originaires du Nord, ou les échanges culturels nés de l’introduction au Sud de la peinture nord-coréenne, les interfaces narratives renvoyant aux discours que chaque Corée construit sur l’Autre, que ce soient les discours officiels (manuels scolaires, agences de presse ou ceux de la fiction (cinéma. Prolongeant le travail des géographes sur la notion, l’article s’efforce de mieux décrire la géométrie du système que constitue une interface (multiplicité des plans et des niveaux de contacts, jeu des synapses et des interstices, prégnance des enclaves non seulement sur le plan spatial mais aussi sur les plans social et narratif et de reconsidérer l’extraordinaire complexité de la culture coréenne contemporaine. Malgré les divergences de vues sur l’existence même d’une interface entre les deux Corées, l’article conclut que l’usage de ce concept a contribué à mettre en évidence la prégnance de cette division au cœur des deux Corées, à tous les niveaux de la sphère sociale et jusque dans le discours des études coréennes. En exposant les frontières divisant les discours et les savoirs sur la péninsule selon un paradigme bipolaire, le concept d’interface a pu permettre de

  15. Fetal cor triatriatum dexter: a report of two cases associated with nuchal edema in early second trimester

    DEFF Research Database (Denmark)

    Maroun, L.L.; Graem, N.; Skibsted, L.

    2008-01-01

    Two early-2nd-trimester fetuses were aborted as a result of nuchal edema and suspected severe heart malformation. At autopsy one fetus demonstrated nuchal edema, mild hydronephrosis, and cor triatriatum dexter associated with ventricular septal defect and tubular hypoplasia of the aortic arch....... The other fetus demonstrated severe nuchal edema, and cor triatriatum dexter was the only malformation. Cor triatriatum dexter is a rare cardiac malformation characterized by division of the right atrium into 2 compartments by a usually fenestrated membrane representing remnants of the right valve...

  16. The New England Journal of Medicine, CorSalud and Cardiovascular Disease The New England Journal of Medicine, CorSalud y las enfermedades cardiovasculares

    Directory of Open Access Journals (Sweden)

    Francisco Luis Moreno Martínez

    2012-03-01

    Full Text Available In order to commemorate the 200th anniversary of The New England Journal of Medicine, the working staff of CorSalud extends its congratulations to this prestigious medical journal. It has been demonstrated the important role this journal played by increasing scientific knowledge, specifically in the specialty of Cardiology and,of course, its editorial quality, based not only on experience but also on professionalism. All this places it as a paradigm to be followed by each and all of the journals in the medical and scientific community.Con motivo del aniversario 200 de The New England Journal of Medicine, el colectivo de CorSalud hace llegar su felicitación a esa prestigiosa publicación médica. Queda manifiesto el importante papel que ha tenido esa revista en el incremento del conocimiento científico, específicamente en la especialidad de Cardiología; y desde luego, su calidad editorial, basadas no solo en experiencia sino también en profesionalismo, la sitúan como paradigma a seguir por todas y cada una de las revistas de la comunidad científica médica.

  17. Lesões de plexo coróide na esquistossomose mansônica

    Directory of Open Access Journals (Sweden)

    Aristides Cheto de Queiroz

    1981-09-01

    Full Text Available O estudo histopatológico do plexo coróide em casos de esquistossomose mansonica na forma hepatoesplênica mostrou a existência de dois tipos de alterações: lesões granulomatosas centradas por ovos do parasito encontradas em 25% dos casos examinados e deposição de material eosinofílico linear ou grumoso de localização subepitelial e no eixo do plexo coróide. A natureza proteica deste material, mostrada pela positividade com a coloração pelo AZAN. sugere a possibilidade de se tratar de complexo imune depositado, a exemplo do que ocorre nos glomerulos renais nesta doença.

  18. Harmonia cromática em animações: a cor no contexto da tecnologia

    OpenAIRE

    Franck, Gláucia

    2015-01-01

    Esta dissertação busca demonstrar a influência recíproca entre a arte e a tecnologia para além do artefato com o uso da cor na obtenção da harmonia cromática e do reforço perceptivo visual e cultural. Procuramos evidenciar como a arte se apropria da tecnologia na obtenção da harmonia pelo uso da cor no processo criativo. A arte, ao ser mediada pela tecnologia, desafia o artista a opor-se ao determinismo tecnológico que impõe resultados pela estandardização do uso de seus aparatos, superando s...

  19. Observations of the star Cor Caroli at the Apple Valley Workshop 2016

    Science.gov (United States)

    Estrada, Reed; Boyd, Sidney; Estrada, Chris; Evans, Cody; Rhoades, Hannah; Rhoades, Mark; Rhoades, Trevor

    2017-06-01

    Using a 22-inch Newtonian Alt/Az telescope and Celestron Micro Guide eyepiece, students participating in a workshop observed the binary star Cor Caroli (STF 1692) and found a position angle of 231.0 degrees as well as an average separation of 18.7" This observation compared favorably with the 2015 Washington Double Star published position. This project was part of Mark Brewer's Apple Valley Double Star Workshop. The results were analyzed using bias and circle error probability calculations.

  20. Melanoma epitelióide de coróide em adolescente: relato de caso

    OpenAIRE

    Araújo Ângelo Augusto; Fontes Anselmo Mariano; Araújo Neta Vitalina Martins de; C. Junior José Fernando; Góis Max Rollemberg

    2004-01-01

    O melanoma maligno de úvea é uma doença muito rara antes dos 30 anos de idade. Este é um relato de um caso de melanoma epitelióide de coróide em adolescente de 12 anos cujo diagnóstico presuntivo foi realizado por exame clínico, ressonância e ultra-sonografia sendo confirmado por meio de exame anatomopatológico.

  1. Cation selectivity by the CorA Mg2+ channel requires a fully hydrated cation.

    Science.gov (United States)

    Moomaw, Andrea S; Maguire, Michael E

    2010-07-27

    The CorA Mg(2+) channel is the primary uptake system in about half of all bacteria and archaea. However, the basis for its Mg(2+) selectivity is unknown. Previous data suggested that CorA binds a fully hydrated Mg(2+) ion, unlike other ion channels. The crystal structure of Thermotoga maritima CorA shows a homopentamer with two transmembrane segments per monomer connected by a short periplasmic loop. This highly conserved loop, (281)EFMPELKWS(289) in Salmonella enterica serovar Typhimurium CorA, is the only portion of the channel outside of the cell, suggesting a role in cation selectivity. Mutation of charged residues in the loop, E281 and K287, to any of several amino acids had little effect, demonstrating that despite conservation electrostatic interactions with these residues are not essential. While mutation of the universally conserved E285 gave a minimally functional channel, E285A and E285K mutants were the most functional, again indicating that the negative charge at this position is not a determining factor. Several mutations at K287 and W288 behaved anomalously in a transport assay. Analysis indicated that mutation of K287 and W288 disrupts cooperative interactions between distinct Mg(2+) binding sites. Overall, these results are not compatible with electrostatic interaction of the Mg(2+) ion with the periplasmic loop. Instead, the loop appears to form an initial binding site for hydrated Mg(2+), not for the dehydrated cation. The loop residues may function to accelerate dehydration of the before entry of Mg(2+) into the pore of the channel.

  2. Cor a 14 is the superior serological marker for hazelnut allergy in children, independent of concomitant peanut allergy

    DEFF Research Database (Denmark)

    Eller, Esben; Mortz, Charlotte G; Bindslev-Jensen, Carsten

    2016-01-01

    BACKGROUND: Hazelnut is the most frequent cause of tree-nut allergy, but up to half of all children with hazelnut allergy additionally suffers from peanut allergy. Our aim was to identify diagnostic values of the most promising serological markers (Cor a 9 and Cor a 14) and to address the influence...... of concomitant peanut allergy and PR10 sensitization. METHOD: We included 155 children suspected off hazelnut allergy and challenged according to guidelines. Concomitant allergy to peanuts was verified or ruled out by challenge. Skin Prick Test, s-IgE and CRD to hazelnut, peanut, PR10 and LPT protein families...... were measured using ImmunoCap. RESULTS: Sixty-five children had a positive hazelnut challenge, and 60% of these also had concomitant peanut allergy. Children allergic to hazelnut were sensitized to Cor a 9 and Cor a 14; peanut allergic children to Ara h 2. Sensitization to PR10 protein components were...

  3. Diagnosis and Surgical Treatment of Congenital Cor Triatrium

    Institute of Scientific and Technical Information of China (English)

    计乐群; 沈宗林; 谭敏; 王志伟

    2002-01-01

    Objectives To evalu-ate the outcome of diagnosis and surgical treatment forcor triatrium (CTA) in 6 patients seen between 1994and 2002. Methods 6 patients ranging in age from 5months to 25 years were observed. All of them hadother cardiovascular defects, and presented with dysp-nea, palpitations (and low weight growing only in theinfants) . Preopreative two dimensional echocardiogra-phy had demonstrated an abnormal septum in the leftatrium and other coexistent anomalies. In 3 of them themembrane was obstructed between the left atrial ac-cessory chamber and the left atrium. The communica-tion were atrial septal defect (ASD) indirectly; Theclinical findings were due to the pulmonary hypervas-cularity. Only one case had a fenestration in the septumwith a small patent foramen ovale (FO) directly , andthe clinical findings were due to the obstruction to flowthrough the membrane in the left atrium, producingvenocapilar pulmonary hypertension. Two of them hadASD and fenestration on the septum. The other coex-istent cardiovascular anomalies were found: 1 hadpartial atrioventricular septal defect (PASD), persis-tent left superior vena cava ( LSVC ) and unroofedcoronary sinus; 1 had Tetralogy of Fallot. (TF). All thecardiovascular defects were confirmed in the opera-tions. Results All the cases underwent the opera-tions through a right atriotomy for completed excision ofthe membrane between the left atrial accessory chamberand left atrium and correction of other anomalies.Postoperative courses were uneventful. No residualobstruction in the left atrium was found before patientswere discharged from the hospital. All of the patientswere followed up for a mean period of 6.5 years(range 0.5 to 8 years) . The clinical symptoms dis-appeared and the patients remained symptom free.Conclusions Echocardiography is of great value inthe diagnosis of the disease preoperatively. Completeexcision of the abnormal septum and proper correctionof the other coexistent cardiovascular anomalies

  4. GNSS Positioning by CORS and EGM2008 in Jilin Province, China.

    Science.gov (United States)

    Wu, Qiong; Kang, Jingyu; Li, Shuwen; Zhen, Jianing; Li, Hongqing

    2015-12-04

    The Continuously Operating Reference Station (CORS) technique has been widely applied in land resource management, surveying, mapping, deformation monitoring, precise navigation, etc. This article analyzed the positioning method using EGM2008 and CORS of Jilin Province, China. The vertical transformation of EGM2008 from WGS84 to China's CGCS2000 datum and the horizontal coordinate transformation from CGCS2000 to a triangulation coordinate system were discussed. The results indicated that a local geoid with respect to CGCS2000 can be transferred from EGM2008 with the same accuracy, and the geoid correction between CGCS2000 and WGS84 varied from 0.023 m to 0.111 m. The coordinate transformation method based on the curve surface approximation method indicated that the theoretical error was less than 0.09 m in the grid within 10° longitudinal and 5° latitudinal, and less than 0.3 m in large area and 0.1 m in small area in field validation. The method proposed in this article expanded the positioning result and its application for JLCORS and other CORS with local datum.

  5. Falha a longo prazo no tratamento do melanoma de coróide com termoterapia transpupilar

    Directory of Open Access Journals (Sweden)

    Gabriela Soncini Pasetto

    2013-08-01

    Full Text Available OBJETIVO: Avaliar, retrospectivamente, num longo intervalo de tempo, os resultados da termoterapia transpupilar em casos selecionados do melanoma de coróide. MÉTODOS: Foram identificados todos os casos com melanoma de coróide tratados com termoterapia transpupilar, como terapia única ou suplementar. Foram excluídos os casos com seguimento inferior a 60 meses, prontuários incompletos ou com o abandono do acompanhamento. RESULTADOS: De um total de 18 olhos, 7 (38.9% foram incluídos no estudo. Cinco (71,4% pacientes foram tratados exclusivamente com termoterapia transpupilar, em 1 (14,2% olho a crioterapia foi simultânea, 1 (14,2% suplementou braquiterapia - placa episcleral. Três (42.8% sofreram recorrência, 2 (28.5% apresentaram metástases (um óbito, 2 foram enucleados. Complicações foram encontradas em 3 olhos: dobras maculares em 2, hemorragia vítrea em 1. Nos olhos enucleados, não havia extensão extraescleral, porém células interesclerais foram identificadas. CONCLUSÃO: Termoterapia transpupilar mostra um declínio em sua eficácia e conserva os riscos de metástases em períodos mais longos de acompanhamento, sendo necessária uma definição mais exata de seu papel nos melanomas de coróide.

  6. Tumores de plexo coróide: estudo epidemiológico comparativo de 24 casos

    Directory of Open Access Journals (Sweden)

    Torres Luiz Fernando Bleggi

    2004-01-01

    Full Text Available Tumores derivados do plexo coróide são neoplasias raras do sistema nervoso central que acometem principalmente crianças. Este estudo apresenta uma série de 38 pacientes com tumores de origem neuroectodérmica, dentre os quais 24 possuem diagnóstico histológico e/ou imunoistoquímico de Carcinoma do Plexo Coróide (CPC. Destes, 16 eram do gênero masculino. O local predominantemente acometido foi o ventrículo lateral esquerdo. As manifestações clínicas mais freqüentes foram hidrocefalia, hipertensão intracraniana e crises convulsivas. Todos os pacientes foram submetidos a tratamento cirúrgico. Houve um óbito no per-operatório e outro no pós-operatório imediato. Nove pacientes tiveram recidiva, evoluindo a óbito em tempo médio de 12,3 meses. Sete estão vivos. Os demais casos não apresentavam dados disponíveis. Em Curitiba, o CPC tem uma alta prevalência em relação a outros tumores do plexo coróide, podendo estar relacionado a algum agente patogênico.

  7. Atrofia girata de coróide e retina : relato de caso

    Directory of Open Access Journals (Sweden)

    Oyamaguchi Emerson Kenji

    2003-01-01

    Full Text Available OBJETIVO: Relatar um caso de atrofia girata de coróide e retina com confirmação por meio da bioquímica do plasma. MÉTODO: Aferiu-se a melhor acuidade visual corrigida de ambos olhos (AO em tabela de Snellen. Foram realizados biomicroscopia do segmento anterior, refração, mapeamento de retina, angiografia fluoresceínica, campo visual e dosagem da ornitina sérica (aminoacidograma. RESULTADOS: Paciente de 22 anos, sexo feminino, cor branca, apresentando alta miopia e acuidade visual (AV 20/100 em AO. À biomicroscopia do segmento anterior apresentava catarata subcapsular posterior em AO. À oftalmoscopia foram verificadas lesões atróficas da coróide e da retina bem delimitadas em meia periferia de AO. O aminoacidograma constatou elevação correspondente ao complexo da ornitina. CONCLUSÃO: Relata-se um caso típico de atrofia girata, distrofia retiniana rara associada a hiperornitinemia.

  8. A structural basis for Mg2+ homeostasis and the CorA translocation cycle.

    Science.gov (United States)

    Payandeh, Jian; Pai, Emil F

    2006-08-23

    We describe the CorA Mg(2+) transporter homologue from Thermotoga maritima in complex with 12 divalent cations at 3.7 A resolution. One metal is found near the universally conserved GMN motif, apparently stabilized within the transmembrane region. This portion of the selectivity filter might discriminate between the size and preferred coordination geometry of hydrated substrates. CorA may further achieve specificity by requiring the sequential dehydration of substrates along the length of its approximately 55 A long pore. Ten metal sites identified within the cytoplasmic funnel domain are linked to long extensions of the pore helices and regulate the transport status of CorA. We have characterized this region as an intrinsic divalent cation sensor and provide evidence that it functions as a Mg(2+)-specific homeostatic molecular switch. A proteolytic protection assay, biophysical data, and comparison to a soluble domain structure from Archaeoglobus fulgidus have revealed the potential reaction coordinate for this diverse family of transport proteins.

  9. The periplasmic loop provides stability to the open state of the CorA magnesium channel.

    Science.gov (United States)

    Palombo, Isolde; Daley, Daniel O; Rapp, Mikaela

    2012-08-10

    Crystal structures of the CorA Mg(2+) channel have suggested that metal binding in the cytoplasmic domain stabilizes the pentamer in a closed conformation. The open "metal free" state of the channel is, however, still structurally uncharacterized. Here, we have attempted to map conformational states of CorA from Thermotoga maritima by determining which residues support the pentameric structure in the presence or absence of Mg(2+). We find that when Mg(2+) is present, the pentamer is stabilized by the putative gating sites (M1/M2) in the cytoplasmic domain. Strikingly however, we find that the conserved and functionally important periplasmic loop is vital for the integrity of the pentamer when Mg(2+) is absent from the M1/M2 sites. Thus, although the periplasmic loops were largely disordered in the x-ray structures of the closed channel, our data suggests a prominent role for the loops in stabilizing the open conformation of the CorA channels.

  10. Terapêutica hormonal na coréia de Sydenham

    Directory of Open Access Journals (Sweden)

    José Geraldo Albernaz

    1957-09-01

    Full Text Available Cinco casos de coréia de Sydenham foram submetidos à terapêutica hormonal com Cortisona, Prednisona e Prednisolona; o fenobarbital e a clorpromazina foram utilizados como medicação sintomática e a Penicilina-Benzatina como profilática. Depois de analisadas as referências bibliográficas, comparados os resultados de ν;rios autores, e ajuizados os resultados obtidos em nossos casos, acreditamos poder concluir que: 1 a terapêutica hormonal da coréia de Sydenham, com o uso de ACTH, Cortisona, Prednisona ou Pred-nisclona apresenta resultados satisfatórios; 2 a Prednisona e a Prednisolona são os hormônios mais úteis no tratamento da coréia de Sydenham, sendo possível que sua associação aos salicilatos permita obter resultados ainda melhores; 3 o tratamento deve prolongar-se até o completo desaparecimento dos sintomas, as doses variando de acôrdo com a gravidade e a evolução da moléstia; 4 a terapêutica hormonal deve ser usada sem prejuízo de medicação sintomática (sedativa e profilática (antibiótica.

  11. Phylo_dCor: distance correlation as a novel metric for phylogenetic profiling.

    Science.gov (United States)

    Sferra, Gabriella; Fratini, Federica; Ponzi, Marta; Pizzi, Elisabetta

    2017-09-05

    Elaboration of powerful methods to predict functional and/or physical protein-protein interactions from genome sequence is one of the main tasks in the post-genomic era. Phylogenetic profiling allows the prediction of protein-protein interactions at a whole genome level in both Prokaryotes and Eukaryotes. For this reason it is considered one of the most promising methods. Here, we propose an improvement of phylogenetic profiling that enables handling of large genomic datasets and infer global protein-protein interactions. This method uses the distance correlation as a new measure of phylogenetic profile similarity. We constructed robust reference sets and developed Phylo-dCor, a parallelized version of the algorithm for calculating the distance correlation that makes it applicable to large genomic data. Using Saccharomyces cerevisiae and Escherichia coli genome datasets, we showed that Phylo-dCor outperforms phylogenetic profiling methods previously described based on the mutual information and Pearson's correlation as measures of profile similarity. In this work, we constructed and assessed robust reference sets and propose the distance correlation as a measure for comparing phylogenetic profiles. To make it applicable to large genomic data, we developed Phylo-dCor, a parallelized version of the algorithm for calculating the distance correlation. Two R scripts that can be run on a wide range of machines are available upon request.

  12. GNSS Positioning by CORS and EGM2008 in Jilin Province, China

    Directory of Open Access Journals (Sweden)

    Qiong Wu

    2015-12-01

    Full Text Available The Continuously Operating Reference Station (CORS technique has been widely applied in land resource management, surveying, mapping, deformation monitoring, precise navigation, etc. This article analyzed the positioning method using EGM2008 and CORS of Jilin Province, China. The vertical transformation of EGM2008 from WGS84 to China’s CGCS2000 datum and the horizontal coordinate transformation from CGCS2000 to a triangulation coordinate system were discussed. The results indicated that a local geoid with respect to CGCS2000 can be transferred from EGM2008 with the same accuracy, and the geoid correction between CGCS2000 and WGS84 varied from 0.023 m to 0.111 m. The coordinate transformation method based on the curve surface approximation method indicated that the theoretical error was less than 0.09 m in the grid within 10° longitudinal and 5° latitudinal, and less than 0.3 m in large area and 0.1 m in small area in field validation. The method proposed in this article expanded the positioning result and its application for JLCORS and other CORS with local datum.

  13. Development of a new hazelnut sandwich ELISA based on detection of Cor a 9, a major hazelnut allergen

    OpenAIRE

    Trashin, Stanislav; Cucu, Tatiana; Devreese, Bart; De Meulenaer, Bruno

    2010-01-01

    The emerging health problem of food-induced allergic reactions, including life-threatening anaphylaxis, presents an important challenge to the food. In the framework of the current ALLERRISK project, analytical approaches for allergen detection are evaluated and developed. Cor a 9 is a major hazelnut protein with nutrient reservoir function, and that also known as a major food allergen. Presence of Cor a 9 indicates contamination of a product with hazelnut and, consequently, potential risk of...

  14. Pulmonale konsekvenser af hashrygning

    DEFF Research Database (Denmark)

    Pfeifer, Andreas Klaus; Lange, Peter

    2006-01-01

    Based on previously published studies, this review describes the pulmonary consequences of marijuana smoking. Smoking of marijuana is significantly associated with chronic bronchitis (cough and phlegm), but it has not been firmly established whether it also leads to a reduction in lung function....... Both epidemiological studies and case reports suggest that regular smokers of marijuana have a higher risk of developing malignancies in both the upper and lower airways. Smoking of marijuana contaminated with fungus spores has been reported to lead to pulmonary aspergillus infections...... in immunocompromised patients, and sharing of marijuana water pipes has been associated with transmission of tuberculosis....

  15. The CorA Mg(2+) transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the second membrane domain.

    Science.gov (United States)

    Szegedy, M A; Maguire, M E

    1999-12-24

    Salmonella typhimurium CorA is the archetypal member of the largest family of Mg(2+) transporters of the Bacteria and Archaea. It contains three transmembrane segments. There are no conserved charged residues within these segments indicating electrostatic interactions are not used in Mg(2+) transport through CorA. Previous mutagenesis studies of CorA revealed a single face of the third transmembrane segment that is important for Mg(2+) transport. In this study, we mutated hydroxyl-bearing and other conserved residues in the second transmembrane segment to identify residues involved in transport. Residues Ser(260), Thr(270), and Ser(274) appear to be important for transport and are oriented such that they would also line a face of an alpha-helix. In addition, the sequence (276)YGMNF(280), found in virtually all CorA homologues, is critical for CorA function because even conservative mutations are not tolerated at these residues. Finally, mutations of residues in the second transmembrane segment, unlike those in the third transmembrane segment, revealed cooperative behavior for the influx of Mg(2+). We conclude that the second transmembrane segment forms a major part of the Mg(2+) pore with the third transmembrane segment of CorA.

  16. The Myxococcus xanthus Two-Component System CorSR Regulates Expression of a Gene Cluster Involved in Maintaining Copper Tolerance during Growth and Development

    Science.gov (United States)

    Sánchez-Sutil, María Celestina; Pérez, Juana; Gómez-Santos, Nuria; Shimkets, Lawrence J.; Moraleda-Muñoz, Aurelio; Muñoz-Dorado, José

    2013-01-01

    Myxococcus xanthus is a soil-dwelling member of the δ–Proteobacteria that exhibits a complex developmental cycle upon starvation. Development comprises aggregation and differentiation into environmentally resistant myxospores in an environment that includes fluctuations in metal ion concentrations. While copper is essential for M. xanthus cells because several housekeeping enzymes use it as a cofactor, high copper concentrations are toxic. These opposing effects force cells to maintain a tight copper homeostasis. A plethora of paralogous genes involved in copper detoxification, all of which are differentially regulated, have been reported in M. xanthus. The use of in-frame deletion mutants and fusions with the reporter gene lacZ has allowed the identification of a two-component system, CorSR, that modulates the expression of an operon termed curA consisting of nine genes whose expression slowly increases after metal addition, reaching a plateau. Transcriptional regulation of this operon is complex because transcription can be initiated at different promoters and by different types of regulators. These genes confer copper tolerance during growth and development. Copper induces carotenoid production in a ΔcorSR mutant at lower concentrations than with the wild-type strain due to lack of expression of a gene product resembling subunit III of cbb3-type cytochrome c oxidase. This data may explain why copper induces carotenoid biosynthesis at suboptimal rather than optimal growth conditions in wild-type strains. PMID:23874560

  17. The Myxococcus xanthus two-component system CorSR regulates expression of a gene cluster involved in maintaining copper tolerance during growth and development.

    Directory of Open Access Journals (Sweden)

    María Celestina Sánchez-Sutil

    Full Text Available Myxococcus xanthus is a soil-dwelling member of the δ-Proteobacteria that exhibits a complex developmental cycle upon starvation. Development comprises aggregation and differentiation into environmentally resistant myxospores in an environment that includes fluctuations in metal ion concentrations. While copper is essential for M. xanthus cells because several housekeeping enzymes use it as a cofactor, high copper concentrations are toxic. These opposing effects force cells to maintain a tight copper homeostasis. A plethora of paralogous genes involved in copper detoxification, all of which are differentially regulated, have been reported in M. xanthus. The use of in-frame deletion mutants and fusions with the reporter gene lacZ has allowed the identification of a two-component system, CorSR, that modulates the expression of an operon termed curA consisting of nine genes whose expression slowly increases after metal addition, reaching a plateau. Transcriptional regulation of this operon is complex because transcription can be initiated at different promoters and by different types of regulators. These genes confer copper tolerance during growth and development. Copper induces carotenoid production in a ΔcorSR mutant at lower concentrations than with the wild-type strain due to lack of expression of a gene product resembling subunit III of cbb3-type cytochrome c oxidase. This data may explain why copper induces carotenoid biosynthesis at suboptimal rather than optimal growth conditions in wild-type strains.

  18. Asymmetry in structural response of inner and outer transmembrane segments of CorA protein by a coarse-grain model

    Science.gov (United States)

    Kitjaruwankul, Sunan; Khrutto, Channarong; Sompornpisut, Pornthep; Farmer, B. L.; Pandey, R. B.

    2016-10-01

    Structure of CorA protein and its inner (i.corA) and outer (o.corA) transmembrane (TM) components are investigated as a function of temperature by a coarse-grained Monte Carlo simulation. Thermal response of i.corA is found to differ considerably from that of the outer component, o.corA. Analysis of the radius of gyration reveals that the inner TM component undergoes a continuous transition from a globular conformation to a random coil structure on raising the temperature. In contrast, the outer transmembrane component exhibits an abrupt (nearly discontinuous) thermal response in a narrow range of temperature. Scaling of the structure factor shows a globular structure of i.corA at a low temperature with an effective dimension D ˜ 3 and a random coil at a high temperature with D ˜ 2. The residue distribution in o.corA is slightly sparser than that of i.corA in a narrow thermos-responsive regime. The difference in thermos-response characteristics of these components (i.corA and o.corA) may reflect their unique transmembrane functions.

  19. InfIuence of Lokomat gait training to cardiopuImonary function of chronic cor puImonaIe parapIegia in stabIe stage%Lokomat步态训练对偏瘫合并慢性稳定期肺心病患者心肺功能的影响

    Institute of Scientific and Technical Information of China (English)

    刘刚; 孙利玲; 钟艺英; 麦景佳; 张剑; 喻国雄

    2016-01-01

    objectiveTo study the influence of Lokomat gait training to cardiopulmonary function of chronic cor pulmonale paraplegia in stable stage, and estimate the clinical safety.Methods72 patients of spastic paraplegia and chronic cor pulmonale in stable stage took Lokomat gait training. Keeping 45 minutes once daily,6 times a week for 4 weeks. Took routine medicine in training period. Before and after training, compared the cardiopulmonary function, blood gas analysis and ECG.ResuIts72 patients completed the rehabilitation training. Under routine training, the pulmonary function index such as BRe, FEV1, FEV1/FVC, MVV, VD/VTe and RV/TLC improved partly but not obviously after 2 weeks (P>0.05), and improved obviously after 4 weeks except RV/TLC (P0.05); under incremental exercise, 3 transient arrhythmia occurred without myocardial ischemia and severe arrhythmia.ConcIusion It is safe that patients of chronic cor pulmonale in stable stage take Lokomat gait training, and cardiopulmonary function can improve in some degree.%目的:探讨Lokomat步态训练对偏瘫合并慢性稳定期肺心病患者心肺功能的影响,评价其临床应用的安全性。方法72例下肢痉挛型偏瘫合并慢性稳定期肺心病患者,应用Lokomat全自动步态训练系统进行适应性减重及递增负荷步态训练,每日1次,45 min/次,每周6次,疗程4周,训练期间常规控制性用药。分别于训练前、第2周、第4周观测比较心肺功能、血气分析及心电图变化。结果72例均完成康复训练。常规训练负荷下运动末呼吸储备(BRe)、1 s用力呼气量占预期值百分比(FEV1%)、1 s用力呼气量/用力肺活量(FEV1/FVC)、每分钟最大通气量(MVV)、残气与肺总量比值(RV/TLC)、运动末生理死腔潮气比值(VD/VTe)等肺功能指标2周后比训练前有部分好转,差异无统计学意义(P>0.05),至第4周时除 RV/TLC 外均有明显改善(P<0.05

  20. CORS-RTK 在海岸侵蚀监测中的应用%The Application of CORS System Based on RTK System in Coastal Erosion Survey

    Institute of Scientific and Technical Information of China (English)

    刘宗强; 刘欣; 韩恒星

    2016-01-01

    This paper introduces application principle of Gps‐Rtk .Take shandong coastal erosion monitoring project for example ,the coastline of monitoring ,river flat terrain ,sea‐wall elevation measurement is given .Briefly summarizes the CORS of Gps‐Rtk technology characteristic and the practical experience during the process of measurement and Gps‐Rtk application prospect .%本文介绍了CORS‐RTK的应用原理,以山东沿海侵蚀监测工程为例,给出岸线监测,岸滩地形测量、海堤高程测量应用示例,简要总结了CORS‐RT K的技术特点和测量过程中的实践经验及CORS‐RTK的技术应用前景。

  1. Respiratory failure

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    970318 A study on evoked potentials in cor pul-monale patients with chronic respiratory failure.QIAO Hui(乔慧), et al. Beijing Neurosurg Instit,Beijing, 100050. Chin J Geriatr 1997; 16(1): 43-45. Objective: Evoked protential was used to detect thechange of brain function in cor pulmonale patients with

  2. Medida da cor em solos do Rio Grande do Sul com a carta de Munsell e por colorimetria

    Directory of Open Access Journals (Sweden)

    Botelho Márcio Ramos

    2006-01-01

    Full Text Available A cor do solo é uma característica facilmente determinada através da comparação visual com a carta de Munsell e está relacionada com a presença de óxidos de ferro e matéria orgânica no solo. A obtenção da cor por instrumentos via sensoriamento remoto, como colorímetros, resulta em maior precisão por apresentar condições controladas e não subjetivas. Os objetivos deste trabalho foram comparar a cor de diferentes solos do Rio Grande do Sul determinadas pela carta de Munsell e por colorimetria e correlacioná-las com os atributos do solo. A precisão dos observadores na determinação da cor através da carta de Munsell para uma mesma amostra apresentou menor variabilidade para o componente matiz e maior para o croma. Os coeficientes de correlação mostraram que há coerência entre as medidas de cor realizadas por diferentes observadores e as medidas pelo colorímetro, o qual mostrou ser eficiente na quantificação da cor, eliminando possíveis erros psicofísicos atribuídos ao método visual. Os atributos dos solos analisados apresentaram boas correlações com os componentes da cor obtidos por colorimetria, mostrando ser esta uma técnica eficiente e promissora para obter informações do solo de maneira simples e de baixo custo.

  3. Cor, betacaroteno e colesterol em gema de ovos obtidos de poedeiras que receberam diferentes dietas

    OpenAIRE

    2006-01-01

    O ovo é um alimento considerado nutricionalmente completo, e contém quantidade significativa de nutrientes. Para os consumidores, a qualidade deste alimento está relacionada com o prazo de validade do produto e com as características sensoriais, como cor da gema e da casca. Poucos estudos foram efetuados no Brasil sobre a utilização de agentes pigmentantes e seus efeitos sobre a coloração das gemas e proporção e qualidade química dos componentes do ovo. Com base nisso, objetivou-se com este t...

  4. 'PiraRoxa': cultivar de alface crespa de cor vermelha intensa

    OpenAIRE

    Sala,Fernando César; Costa,Cyro Paulino da

    2005-01-01

    'PiraRoxa' é uma cultivar de alface (Lactuca sativa L.) crespa de cor vermelha intensa, resistente à Bremia lactucae, Thielaviopsis basicola e LMV, patótipo II. Foi selecionada por meio do método genealógico a partir do cruzamento entre o tipo Lolla Rossa 'RS 521998' e a cv. Gizela. Apresenta plantas grandes e vigorosas, folhas crespas, coloração vermelha intensa e brilhante. Em ensaios conduzidos no verão (2003/2004) o pendoamento da 'PiraRoxa' foi de 10 e 20 dias mais lento quando comparado...

  5. Breve espaço entre cor e sombra: literatura e artes plásticas

    OpenAIRE

    2010-01-01

    O presente trabalho tem por objetivo analisar o romance Breve espaço entre cor e sombra, de Cristovão Tezza, seguindo os preceitos da literatura comparada. A obra transita entre a literatura e as artes plásticas, tornando-se, portanto, imprescindível conceituar o que é arte, entender os caminhos que ela vem percorrendo desde os primórdios e destacar algumas marcas presentes nas obras de artistas da modernidade. Uma vez que o fio condutor do romance gira em torno de uma falsa cabeça esculpida ...

  6. Detecção de componentes faciais baseado em modelos de cor e antropometria

    OpenAIRE

    Moreira, Juliano Lucas

    2010-01-01

    Existem diferentes situações em que a detecção de componentes faciais desempenha um papel importante, como por exemplo: no reconhecimento facial, interação humano computador, teleconferências, análise de expressões faciais e animação. Esta dissertação apresenta, primeiramente, uma revisão bibliográfica dos trabalhos referentes à detecção dos componentes faciais. Após, é exposto o modelo desenvolvido para a detecção de componentes faciais, sendo este baseado em modelos de cor e antropometria. ...

  7. [Tumoral microembolism and cor-pulmonar as manifestation of hepatocelular carcinoma].

    Science.gov (United States)

    Canelo Aybar, Carlos Gilberto; Cuadra Urteaga, José Luís; Fujii, F; Romaní Romaní, Franco; Atencia Matute, Fernando Alonso; Verona Rubio, Rogger Oscar

    2008-01-01

    The tumour pulmonary micro-embolism is a rare condition characterized by the occlusion of pulmonary small arteries, arteriolas, and alveolar capillaries septales, accompanied of trombosis. Occasionally the development of pulmonary hypertension is the first manifestation of an occult neoplasia, in series of autopsies, an incidence from 3 to 26% has been reported in solid tumors, being clinical evident in 8%. Few cases have documented the development of this condition in patients with carcinoma hepatocelular, we report the case of a 16-year-old male who comes to the emergency with signs of cardiac insufficiency and cor pulmonare whose anatomopatological study confirmed a tumour massive microembolic compromise at pulmonary level and hepatocarcinoma.

  8. Thrombosed cor triatriatum sinistrum mimicking left atrial mass and causing unilateral pulmonary edema.

    Science.gov (United States)

    Gonzalez Lengua, Carlos A; Kumar, Pirkash; Cham, Matthew; Sanz, Javier

    2016-01-01

    46 year old female with history of progressive shortness of breath for 3 years associated with recurrent right lung infiltrates and hemoptisis. A computed tomography of the chest showed a left atrial mass suggestive of atrial myxoma confirmed with transesophageal echocardiogram. Contrary with findings from a dedicated EKG gated cardiac computed tomography suggestive of cor triatriatum with associated thrombus and less likely a neoplasm; findings later on confirmed during surgery. Cardiac CT offers superior spatial resolution and multi-planar image reconstructions, allowing improved characterization of cardiac structures and cardiac masses compared to other traditional cardiovascular imaging modalities.

  9. Experimental study of partially-cured Z-pins reinforced foam core composites:K-Cor sandwich structures

    Institute of Scientific and Technical Information of China (English)

    Zheng Yingying; Xiao Jun; Duan Mufeng; Li Yong

    2014-01-01

    This paper presents an experimental study of a novel K-Cor sandwich structure rein-forced with partially-cured Z-pins. The influence of pultrusion processing parameters on Z-pins characteristics was studied and the effect of Z-pins on mechanical properties was disclosed. Differential scanning calorimetry (DSC) and optical microscopy (OM) methods were employed to determine the curing degree of as-prepared Z-pins and observe the implanted Z-pins in the K-Cor structure. These partially-cured Z-pins were treated with a stronger bonding link between face sheets and the foam core by means of a hot-press process, thereby decreasing burrs and cracking defects when the Z-pins were implanted into the Rohacell foam core. The results of the out-of-plane tensile tests and the climbing drum peel (CDP) tests showed that K-Cor structures exhibited superior mechanical performance as compared to X-Cor and blank foam core. The observed results of failure modes revealed that an effective bonding link between the foam core and face sheets that was provided from partially-cured Z-pins contributed to the enhanced mechan-ical performances of K-Cor sandwich structures.

  10. Experimental study of partially-cured Z-pins reinforced foam core composites: K-Cor sandwich structures

    Directory of Open Access Journals (Sweden)

    Zheng Yingying

    2014-02-01

    Full Text Available This paper presents an experimental study of a novel K-Cor sandwich structure reinforced with partially-cured Z-pins. The influence of pultrusion processing parameters on Z-pins characteristics was studied and the effect of Z-pins on mechanical properties was disclosed. Differential scanning calorimetry (DSC and optical microscopy (OM methods were employed to determine the curing degree of as-prepared Z-pins and observe the implanted Z-pins in the K-Cor structure. These partially-cured Z-pins were treated with a stronger bonding link between face sheets and the foam core by means of a hot-press process, thereby decreasing burrs and cracking defects when the Z-pins were implanted into the Rohacell foam core. The results of the out-of-plane tensile tests and the climbing drum peel (CDP tests showed that K-Cor structures exhibited superior mechanical performance as compared to X-Cor and blank foam core. The observed results of failure modes revealed that an effective bonding link between the foam core and face sheets that was provided from partially-cured Z-pins contributed to the enhanced mechanical performances of K-Cor sandwich structures.

  11. La construction du « soft power » : l’exemple de la Corée du Sud

    Directory of Open Access Journals (Sweden)

    Eric Bidet

    2013-01-01

    Full Text Available Depuis quelques années, la Corée du Sud apparaît comme un pays doté d’un soft power significatif, présentant notamment une dimension culturelle particulièrement développée. Le succès mondial rencontré en 2012 par le chanteur Psy avec son clip vidéo Gangnam Style et la visibilité internationale acquise par certains artistes emblématiques de la K-pop (musique pop coréenne y sont pour beaucoup mais n’en représentent qu’une facette qui ne permet pas à elle seule de saisir les différents éléments caractéristiques de ce soft power. Celui-ci s’appuie en premier lieu sur l’émergence de la Corée comme puissance économique, et plus spécialement comme puissance commerciale exportatrice, qui en fait un modèle pour de nombreuses économies émergentes. Il repose par ailleurs sur une politique active de développement des industries culturelles et de diffusion des produits culturels coréens à l’international. En d’autres termes, le soft power coréen repose sur une synergie particulièrement réussie entre puissance économique et industries culturelles.

  12. Structure and Cooperativity of the Cytosolic Domain of the CorA Mg(2+) Channel from Escherichia coli.

    Science.gov (United States)

    Lerche, Michael; Sandhu, Hena; Flöckner, Lukas; Högbom, Martin; Rapp, Mikaela

    2017-08-01

    Structures of the Mg(2+) bound (closed) and apo (open) states of CorA suggests that channel gating is accomplished by rigid-body motions between symmetric and asymmetric assemblies of the cytosolic portions of the five subunits in response to ligand (Mg(2+)) binding/unbinding at interfacial sites. Here, we structurally and biochemically characterize the isolated cytosolic domain from Escherichia coli CorA. The data reveal an Mg(2+)-ligand binding site located in a novel position between each of the five subunits and two Mg(2+) ions trapped inside the pore. Soaking experiments show that cobalt hexammine outcompetes Mg(2+) at the pore site closest to the membrane. This represents the first structural information of how an analog of hexa-hydrated Mg(2+) (and competitive inhibitor of CorA) associates to the CorA pore. Biochemical data on the isolated cytoplasmic domain and full-length protein suggests that gating of the CorA channel is governed cooperatively. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. The Application of the CORS in Urban Water Pipeline Positioning%CORS 在城市供水管线定位中的应用

    Institute of Scientific and Technical Information of China (English)

    刘荣强; 陈彬

    2013-01-01

    供水管线系统是否完善是衡量城市规划是否合理的重要指标,其中设施的定位至关重要,将直接影响到整个管线系统的质量及维护更新和事故排查的效率。针对供水管线分布密度高、更新速度快、类型复杂等特点,CORS是一种实用有效的测量定位方法。本文研究CORS在城市供水管线测量定位中的应用,结合武汉市管线设施竣工测量的案例,用多项指标验证了成果的精度及该方法的可行性,并结合其他定位方法分析,为供水管线设施的定位提供参考意见。%Whether the water pipeline system is perfect or not is an important indicator of whether a urban planning is reasonable or not ,and the plumbing facilities positioning which will directly affects the quality and the efficiency of ma -intenance ,updating and troubleshoot of the entire pipeline system is critical .For characteristics of high distribution den-sity,high updating speed and complexity of types of the water pipeline facilities distribution ,CORS is a practical and ef-fective measuring and positioning method .The article studies the application of the CORS in measuring and positioning of urban water pipeline ,and combined with the cases of the completion measuring of water pipeline facilities in Wuhan ,veri-fies the accuracy and feasibility of measuring result of this method with various kinds of indicators ,and by comprehensive analysis combined with other positioning methods ,provides reference for the positioning methods of the water pipeline fa-cilities.

  14. Pulmonary tumor thrombotic microangiopathy in an unknown primary cancer

    Directory of Open Access Journals (Sweden)

    Gayathri P Amonkar

    2014-01-01

    Full Text Available Pulmonary tumor thrombotic microangiopathy (PTTM is a highly fatal complication of cancer leading to acute cor pulmonale and pulmonary hypertension. We present a case of 47-year-old male patient who developed acute breathlessness and died suddenly. The pulmonary vessels at autopsy on histopathologic examination showed the presence of fibrocellular intimal proliferation, fibrin thrombi and few tumor emboli consisting of malignant adenocarcinoma cells. There was associated lymphangiosis carcinomatosis. No primary visceral tumor was found despite extensive search. The patient had died following acute cor pulmonale with sudden pulmonary hypertension due to PTTM. This entity (PTTM must be kept as a differential diagnosis in patients presenting with acute breathlessness especially in cases of cancers.

  15. Conflitos de gerações: Gustavo Corção e a juventude católica (Generation conflict: Gustavo Corção and Catholic Youth

    Directory of Open Access Journals (Sweden)

    Christiane Jalles de Paula

    2012-07-01

    Full Text Available Este artigo aborda o combate que empreendeu Gustavo Corção à juventude católica brasileira nas páginas do Diário de Notícias e d’ O Globo entre as décadas de 1950 e de 1960. No caso em tela, interessa-nos entender as reações de Gustavo Corção às mudanças na sociedade e na Igreja Católica entre 1957 e 1964. A hipótese é que as críticas de Corção explicitam o conflito entre duas gerações de católicos: uma conservadora; a dele; e outra progressista, a das organizações de jovens católicos, mais especificamente, a da Juventude Universitária Católica (JUC. Apresentaremos a disputa a partir do exame da seguinte questão: o papel que a juventude brasileira deveria desempenhar naqueles anos. O objetivo é mostrar que suas críticas à opção de ação temporal assumida pelas organizações de juventude católica devem ser lidas pela chave do conflito geracional que marcou o campo católico brasileiro. Palavras-chave: Catolicismo. Gerações. Gustavo Corção. Juventude católica.   Abstract: This paper discusses the fight of Brazilian Catholic Youth Gustavo Corção in the newspapers Diário de Notícias and O Globo in the 1950s and 1960s. In case we are interested in understanding the reactions of Gustavo Corção to changes in society and the Catholic Church between 1957 and 1964. The hypothesis is that the criticism of Corção explains the conflict between two generations of Catholics: a conservative and other progressive, represented by the Catholic youth organizations, more specifically, the Youth Catholic University. We are going to examine the question: the role that Brazilian youth should play in those years. Therefore, the aim is to show that his criticism of the political action undertaken by the young catholic organizations should be read by the key of generation conflict which has marked the Brazilian Catholic field. Keywords: Catholicism. Generations. Gustavo Corção. Catholic youth organizations.

  16. Gustavo Corção: apóstolo da 'linha-dura'

    Directory of Open Access Journals (Sweden)

    Christiane Jalles de Paula

    2012-01-01

    Full Text Available O objetivo deste artigo é analisar as crônicas de Gustavo Corção na imprensa brasileira (Diário de Notícias e O Globo entre 1964 e 1968. A hipótese é que Gustavo Corção foi um dos artífices na esfera pública brasileira da legitimação das bases antidemocráticas da 'democracia' do regime militar. Além disso, a sua definição pela 'linha-dura' relacionou-se aos inimigos escolhidos, quase sempre personalidades católicas. Com isso poderemos perceber tanto aspectos da participação do laicato como da relação que se estabeleceu entre o Estado brasileiro e a Igreja católica no período em tela. O artigo procura demonstrar que é preciso mais atenção à recuperação dos sentidos de democracia que os grupos sociais mobilizaram naquele período, menos para justificar suas ações, e sim para entendê-las e contextualizá-las.

  17. Septicemia decorrente de pododermatites em canários de cor (Serinus canarius

    Directory of Open Access Journals (Sweden)

    A. Borsa

    2013-06-01

    Full Text Available Relataram-se um surto de pododermatite e quadro septicêmico em aves de um canaril comercial. Quarenta e quatro canários de cor foram escolhidos de forma aleatória, sem distinção de sexo, idade ou cor, os quais vieram a óbito naturalmente, após terem sido afetados pela pododermatite, sem que tivessem se submetido a tratamento prévio. As aves mortas foram encaminhadas para o exame necroscópico, onde amostras de tecidos das áreas afetadas foram colhidas para exames microbiológico, micológico e histológico. Todas as aves necropsiadas apresentavam pododermatite, com inflamação em um ou mais dedos, de aspecto nodular, com ou sem presença de úlceras ou necrose. Staphylococcus aureus plasma coagulase positivo foi isolado dos pés e do fígado de todas as aves. Foi observado que todas as linhagens isoladas foram resistentes aos antimicrobianos da classe das penicilinas (penicilina G e ampicilina e parcialmente sensíveis ou resistentes à ciprofloxacina. Apenas metade dos isolados foram sensíveis à neomicina e à estreptomicina. Problemas de saúde pública podem estar relacionados ao surgimento de animais reservatórios de cepas multirresistentes para seres humanos contactantes, como neste caso.

  18. Anaesthetic management for balloon dilation of cor triatriatum dexter in a dog.

    Science.gov (United States)

    De Monte, Valentina; Staffieri, Francesco; Caivano, Domenico; Bufalari, Antonello

    2015-06-10

    A three-month-old female Rottweiler puppy was referred for intravascular correction of a previously identified cor triatriatum dexter. Echocardiography confirmed the presence of a hyperechoic membrane that divided the right atrium into a cranial and caudal chamber. A foramen in this membrane allowed the blood to flow from the caudal to the cranial chamber. Balloon dilation of the defect under transthoracic echocardiographic guidance was scheduled for the following day. The dog was premedicated with 0.5 μg/kg sufentanil and 0.2 mg/kg midazolam administered intravenously. General anaesthesia was induced with 2 mg/kg propofol and maintained with inhaled isoflurane in oxygen; at the same time, a constant rate infusion of 0.5 μg/kg/h sufentanil was administered by means of an infusion pump. Uneventful ventricular and supraventricular tachyarrhythmias developed during the placement of catheters and balloon dilation. At the end of procedure, when the guide wire and balloon catheter were removed, normal sinus rhythm was observed. To the authors' knowledge, no previous reports have described the anaesthetic management of a balloon dilation procedure for cor triatriatum dexter in dogs.

  19. Stent placement for palliation of cor triatriatum dexter in a dog with suspected patent foramen ovale.

    Science.gov (United States)

    Barncord, Kristin; Stauthammer, Christopher; Moen, Sean L; Hanson, Melissa; Gruenstein, Daniel H

    2016-03-01

    An 11 month old spayed, female dog presented with exercise intolerance and cyanosis upon exertion. Echocardiography revealed an imperforate cor triatriatum dexter with mild tricuspid valve dysplasia, an underfilled right ventricle and significant right to left shunting across a presumptive patent foramen ovale. Balloon dilation of the abnormal atrial membrane was initially successful in creating a communication between the right atrial chambers, but stenosis of the original perforation and persistent clinical signs prompted a second intervention. A balloon expandable biliary stent was placed across the abnormal partition, improving caudal venous return to the right ventricle and reducing the right to left shunt. Three months after stent placement, resting oxygen saturation had normalized. Six months after stent placement, exercise tolerance had improved and exertional cyanosis had resolved. Long term follow up will be necessary to assess for remodeling of the right ventricle with improved venous return. Stent placement can be considered as a palliative treatment option for cor triatriatum dexter, especially for stenosis post-balloon dilation.

  20. Lesões expansivas do plexo coróide Choroid plexus mass lesions

    Directory of Open Access Journals (Sweden)

    Ernesto Lima Araújo Melo

    2003-12-01

    Full Text Available As lesões expansivas do plexo coróide constituem um grupo bastante amplo e heterogêneo de doenças e seus simuladores. Tumores, infecções, anomalias congênitas, hemorragias, cistos e fenômenos degenerativos são alguns dos exemplos de causas de lesões expansivas do plexo coróide. No presente trabalho fizemos revisão da literatura pertinente, descrevendo os achados de imagem e ilustrando-os com alguns casos do nosso serviço. Apesar de não existir na literatura descrição de sinais patognomônicos, a avaliação criteriosa e sistemática das características das lesões pode sugerir determinada etiologia.Choroid plexus mass lesions encompass a broad and heterogeneous group of diseases and their simulators. Tumors, infections, congenital anomalies, hemorrhage, cysts and degenerative diseases are some examples of mass lesions affecting the choroid plexus. In this article we review the current literature, describing the imaging findings and illustrating choroid plexus mass lesions with some cases diagnosed at our facility. Despite the inexistence of pathognomonic signs, a careful and systematic evaluation of the imaging characteristics may suggest many etiologies.

  1. Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA.

    Directory of Open Access Journals (Sweden)

    Chris Neale

    2015-07-01

    Full Text Available Ion channels catalyze ionic permeation across membranes via water-filled pores. To understand how changes in intracellular magnesium concentration regulate the influx of Mg2+ into cells, we examine early events in the relaxation of Mg2+ channel CorA toward its open state using massively-repeated molecular dynamics simulations conducted either with or without regulatory ions. The pore of CorA contains a 2-nm-long hydrophobic bottleneck which remained dehydrated in most simulations. However, rapid hydration or "wetting" events concurrent with small-amplitude fluctuations in pore diameter occurred spontaneously and reversibly. In the absence of regulatory ions, wetting transitions are more likely and include a wet state that is significantly more stable and more hydrated. The free energy profile for Mg2+ permeation presents a barrier whose magnitude is anticorrelated to pore diameter and the extent of hydrophobic hydration. These findings support an allosteric mechanism whereby wetting of a hydrophobic gate couples changes in intracellular magnesium concentration to the onset of ionic conduction.

  2. Structural Dynamics of the Magnesium-bound Conformation of CorA in a lipid bilayer

    Science.gov (United States)

    Dalmas, Olivier; Cuello, Luis G.; Jogini, Vishwanath; Cortes, D. Marien; Roux, Benoit; Perozo, Eduardo

    2010-01-01

    Summary The transmembrane conformation of Thermotoga maritima CorA, a Magnesium transport system, has been studied in it’s Mg2+-bound form by site-directed spin labeling and electron paramagnetic resonance spectroscopy. Probe mobility together with accessibility data were used to evaluate the overall dynamics and relative arrangement of individual transmembrane segments TM1 and TM2. TM1 extends toward the cytoplasmic side creating a water filled cavity, while TM2 is located in the periphery of the oligomer, contacting the lipid bilayer. A structural model for the conserved extracellular loop was generated based on EPR data and MD simulations, in which residue E316 is located towards the fivefold symmetry axis in position to electrostatically influence divalent ion translocation. Electrostatic analyses of our model suggest that, in agreement with the crystal structure, Mg2+ -bound CorA is in a close conformation. The present results suggest that long-range structural rearrangements are necessary to allow Mg2+ translocation. PMID:20637423

  3. Coréia aguda na gravidez Acute chorea in pregnancy: comments on twelve consecutive cases

    Directory of Open Access Journals (Sweden)

    Walter C. Pereira

    1967-12-01

    Full Text Available São apresentados doze casos de coréia aguda observados entre 150.000 gestantes (1/12.500. A maioria dos surtos ocorreu no segundo trimestre da primeira gravidez. A duração média dos sintomas foi de três meses, não tendo sido registrado caso algum de óbito materno. Todos os partos foram espontâneos e normais. Houve apenas um óbito fetal conseqüente a choque hemorrágico. São tecidas considerações a propósito dos aspectos clínico, laboratorial e prognóstico da coréia gravídica, sendo focalizado mais pormenorizadamente o problema fisiopatogênico dessa afecção.Twelve consecutive cases of acute chorea occurring among 150.000 pregnant women (1/12.500 are reported. Most of the cases occurred from the fourth do the sixth month of the first pregnancy. The average duration of the symptoms was of three months and no one case of maternal death was verified in the group. The deliveries were spontaneous and normal in all the patients. Only one case of fetal death occurred in consequence of a hemorragic shock. Comments are made on the clinical, laboratorial and prognostic features of chorea gravidarum, being particulary focused the physiopathogenic problem of this condtion.

  4. Structural dynamics of the magnesium-bound conformation of CorA in a lipid bilayer.

    Science.gov (United States)

    Dalmas, Olivier; Cuello, Luis G; Jogini, Vishwanath; Cortes, D Marien; Roux, Benoit; Perozo, Eduardo

    2010-07-14

    The transmembrane conformation of Thermotoga maritima CorA, a magnesium transport system, has been studied in its Mg(2+)-bound form by site-directed spin labeling and electron paramagnetic resonance spectroscopy. Probe mobility together with accessibility data were used to evaluate the overall dynamics and relative arrangement of individual transmembrane segments TM1 and TM2. TM1 extends toward the cytoplasmic side creating a water-filled cavity, while TM2 is located in the periphery of the oligomer, contacting the lipid bilayer. A structural model for the conserved extracellular loop was generated based on EPR data and MD simulations, in which residue E316 is located toward the five-fold symmetry axis in position to electrostatically influence divalent ion translocation. Electrostatic analysis of our model suggest that, in agreement with the crystal structure, Mg(2+) -bound CorA is in a closed conformation. The present results suggest that long-range structural rearrangements are necessary to allow Mg(2+) translocation. Copyright 2010 Elsevier Ltd. All rights reserved.

  5. Production and biophysical characterization of the CorA transporter from Methanosarcina mazei.

    Science.gov (United States)

    Veesler, David; Blangy, Stéphanie; Siponen, Marina; Vincentelli, Renaud; Cambillau, Christian; Sciara, Giuliano

    2009-05-01

    We report here a general strategy to overproduce and characterize membrane transporters. To illustrate our approach, we selected one member of the CorA transporter family among four tested that belonged to different species. This approach is transposable to other membrane proteins and involves the following steps: (i) cloning by homologous recombination, (ii) high-throughput expression screening, (iii) fermenter-based large-scale production, (iv) high-throughput detergent solubilization screening, (v) protein purification, (vi) multiangle static light scattering/refractometry characterization of purified proteins, (vii) circular dichroism spectroscopy, and (viii) detergent concentration measurements by Fourier transform infrared (FT-IR) spectroscopy. Methanosarcina mazei CorA was expressed in milligram quantities and purified (> 95% pure). n-Dodecyl-beta-D-maltopyranoside (DDM) retained the pentameric native structure of this transporter; thus, we selected it as working detergent. Furthermore, we measured the detergent concentration in our purified and concentrated protein sample by FT-IR to maintain it as low as possible. Our strategy can be adapted to many structural biology approaches as well as for study of single membrane proteins in a variety of conditions.

  6. Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA.

    Science.gov (United States)

    Neale, Chris; Chakrabarti, Nilmadhab; Pomorski, Pawel; Pai, Emil F; Pomès, Régis

    2015-07-01

    Ion channels catalyze ionic permeation across membranes via water-filled pores. To understand how changes in intracellular magnesium concentration regulate the influx of Mg2+ into cells, we examine early events in the relaxation of Mg2+ channel CorA toward its open state using massively-repeated molecular dynamics simulations conducted either with or without regulatory ions. The pore of CorA contains a 2-nm-long hydrophobic bottleneck which remained dehydrated in most simulations. However, rapid hydration or "wetting" events concurrent with small-amplitude fluctuations in pore diameter occurred spontaneously and reversibly. In the absence of regulatory ions, wetting transitions are more likely and include a wet state that is significantly more stable and more hydrated. The free energy profile for Mg2+ permeation presents a barrier whose magnitude is anticorrelated to pore diameter and the extent of hydrophobic hydration. These findings support an allosteric mechanism whereby wetting of a hydrophobic gate couples changes in intracellular magnesium concentration to the onset of ionic conduction.

  7. Carcinoma de plexo coróide: relato de quinze casos

    Directory of Open Access Journals (Sweden)

    BLEGGI-TORRES LUIZ F.

    2000-01-01

    Full Text Available O carcinoma de plexo coróide (CPC é um raro tumor do sistema nervoso central (SNC, derivado do epitélio de revestimento dos plexos coróides, que acomete pacientes abaixo dos 3 anos de idade. Apresentamos um estudo clínico, epidemiológico e histopatológico de 15 casos de CPC. Destes, 10 eram do gênero masculino. As idades variaram de 4 meses a 21 anos. Quanto a localização, acometeram predominante o ventrículo lateral (73,3%. Os sinais e sintomas predominantes foram hidrocefalia (62,5%, hipertensão intracrania (25% e crise convulsiva (12,5%. Os pacientes foram submetidos a tratamento cirúrgico com ressecção parcial em 75% dos casos e completa em 25%. Houve um óbito per-operatório. Em 85,7% dos pacientes houve recidiva tumoral, com evolução a óbito em média 13,6 meses após o diagnóstico. Apenas um paciente encontra-se vivo num seguimento de 5 anos. Esses dados suportam o prognóstico sombrio e a alta mortalidade do CPC.

  8. Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution.

    Science.gov (United States)

    Eshaghi, Said; Niegowski, Damian; Kohl, Andreas; Martinez Molina, Daniel; Lesley, Scott A; Nordlund, Pär

    2006-07-21

    CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2+ transporter of Bacteria and Archaea. We have determined a 2.9 angstrom resolution structure of CorA from Thermotoga maritima that reveals a pentameric cone-shaped protein. Two potential regulatory metal binding sites are found in the N-terminal domain that bind both Mg2+ and Co2+. The structure of CorA supports an efflux system involving dehydration and rehydration of divalent metal ions potentially mediated by a ring of conserved aspartate residues at the cytoplasmic entrance and a carbonyl funnel at the periplasmic side of the pore.

  9. Danos provocados por coró-das-pastagens em plantas de eucalipto Damages caused by coró-das-pastagens in eucalypt

    Directory of Open Access Journals (Sweden)

    Juliana Garlet

    2009-04-01

    Full Text Available Esta nota tem por objetivo relatar o ataque de larvas do coró-das-pastagens, Diloboderus abderus Sturm, 1826 (Coleoptera: Melolonthidae, em mudas de eucalipto híbrido (Eucalyptus grandis x Eucalyptus urophylla, na fazenda Bazana, município de Manoel Viana, Rio Grande do Sul. Essa praga se alimentou da casca das plantas na região do coleto, provocando “anelamento” das mudas. A mortalidade de mudas foi de 30% em 40ha. Este é o primeiro registro dos danos desse inseto em plantas de eucalipto no Brasil.This article aims to report the attack of larvae Diloboderus abderus Sturm, 1826 (Coleoptera: Melolonthidae on seedlings of Eucalyptus hybrid ( Eucalyptus grandis x Eucalyptus urophylla, on the farm Bazana, in Manoel Viana, state of Rio Grande do Sul, Brazil. This pest consumed the bark of the ground, which caused the 'girdling' of seedlings. The mortality rate was 30%, in 40ha. No previous report was found in the literature regarding the occurrence of damages of Diloboderus abderus on Eucalyptus; thus, this is the first record of the pest on Eucalyptus in Brazil.

  10. Regulation of CorA Mg2+ Channel Function Affects the Virulence of Salmonella enterica Serovar Typhimurium ▿

    OpenAIRE

    Papp-Wallace, Krisztina M.; Maguire, Michael E.

    2008-01-01

    The CorA Mg2+ channel is the primary source of intracellular Mg2+ in Salmonella enterica serovar Typhimurium. In another study, we found that a strain lacking corA was attenuated in mice and also defective for invasion and replication within Caco-2 epithelial cells (K. M. Papp-Wallace, M. Nartea, D. G. Kehres, S. Porwollik, M. McClelland, S. J. Libby, F. C. Fang, and M. E. Maguire, J. Bacteriol. 190:6517-6523, 2008). Therefore, we further examined Salmonella interaction with Caco-2 epithelial...

  11. CorA, the magnesium/nickel/cobalt transporter, affects virulence and extracellular enzyme production in the soft rot pathogen Pectobacterium carotovorum.

    Science.gov (United States)

    Kersey, Caleb M; Agyemang, Paul A; Dumenyo, C Korsi

    2012-01-01

    Pectobacterium carotovorum (formerly Erwinia carotovora ssp. carotovora) is a phytopathogenic bacterium that causes soft rot disease, characterized by water-soaked soft decay, resulting from the action of cell wall-degrading exoenzymes secreted by the pathogen. Virulence in soft rot bacteria is regulated by environmental factors, host and bacterial chemical signals, and a network of global and gene-specific bacterial regulators. We isolated a mini-Tn5 mutant of P. carotovorum that is reduced in the production of extracellular pectate lyase, protease, polygalacturonase and cellulase. The mutant is also decreased in virulence as it macerates less host tissues than its parent and is severely impaired in multiplication in planta. The inactivated gene responsible for the reduced virulent phenotype was identified as corA. CorA, a magnesium/nickel/cobalt membrane transporter, is the primary magnesium transporter for many bacteria. Compared with the parent, the CorA(-) mutant is cobalt resistant. The mutant phenotype was confirmed in parental strain P. carotovorum by marker exchange inactivation of corA. A functional corA(+) DNA from P. carotovorum restored exoenzyme production and pathogenicity to the mutants. The P. carotovorum corA(+) clone also restored motility and cobalt sensitivity to a CorA(-) mutant of Salmonella enterica. These data indicate that CorA is required for exoenzyme production and virulence in P. carotovorum. © 2011 THE AUTHORS. MOLECULAR PLANT PATHOLOGY © 2011 BSPP AND BLACKWELL PUBLISHING LTD.

  12. Exploring the structure and function of Thermotoga maritima CorA reveals the mechanism of gating and ion selectivity in Co2+/Mg2+ transport.

    Science.gov (United States)

    Nordin, Nurhuda; Guskov, Albert; Phua, Terri; Sahaf, Newsha; Xia, Yu; Lu, Siyan; Eshaghi, Hojjat; Eshaghi, Said

    2013-05-01

    The CorA family of divalent cation transporters utilizes Mg2+ and Co2+ as primary substrates. The molecular mechanism of its function, including ion selectivity and gating, has not been fully characterized. Recently we reported a new structure of a CorA homologue from Methanocaldococcus jannaschii, which provided novel structural details that offered the conception of a unique gating mechanism involving conversion of an open hydrophilic gate into a closed hydrophobic one. In the present study we report functional evidence for this novel gating mechanism in the Thermotoga maritima CorA together with an improved crystal structure of this CorA to 2.7 Å (1 Å=0.1 nm) resolution. The latter reveals the organization of the selectivity filter to be similar to that of M. jannaschii CorA and also the previously unknown organization of the second signature motif of the CorA family. The proposed gating is achieved by a helical rotation upon the binding of a metal ion substrate to the regulatory binding sites. Additionally, our data suggest that the preference of this CorA for Co2+ over Mg2+ is controlled by the presence of threonine side chains in the channel. Finally, the roles of the intracellular metal-binding sites have been assigned to increased thermostability and regulation of the gating. These mechanisms most likely apply to the entire CorA family as they are regulated by the highly conserved amino acids.

  13. DnaK and DnaJ facilitated the folding process and reduced inclusion body formation of magnesium transporter CorA overexpressed in Escherichia coli.

    Science.gov (United States)

    Chen, Yong; Song, Jinmei; Sui, Sen-fang; Wang, Da-Neng

    2003-12-01

    Overexpression of CorA, the major magnesium transporter from bacterial inner membrane, in Escherichia coli resulted in the synthesis of 60mg of protein per liter of culture, most of which however was in the form of inclusion bodies. The levels of inclusion body formation were reduced by lowering the cell culture temperature. To dissect CorA inclusion body formation and the folding process involved, we co-expressed the protein with various chaperones and other folding modulators. Expression of DnaK/DnaJ (Hsp70) prevented inclusion bodies from forming and resulted in the integration of more CorA into the membrane. GroEL/GroES (Hsp60/Hsp10) were less effective at reducing CorA inclusion body formation. Co-expression with either Ffh/4.5S-RNA, the signal recognition particle, or SecA, the ATPase that drives protein insertion into the membrane, had little effect on CorA folding. These results indicate: (1) that CorA inclusion bodies form immediately after synthesis at 37 degrees C, (2) that CorA solubility in the cytosol can be increased by co-expressing a chaperone system, (3) membrane targeting is probably not a rate-limiting factor, and (4) that membrane insertion becomes a limitation only when large amounts of soluble CorA are present in the cytosol. These co-expression systems can be used for producing other membrane proteins in large quantities.

  14. Metástases de coróide de origem testicular: relato de caso Choroid metastasis of testicular primary site: case report

    Directory of Open Access Journals (Sweden)

    Marcos Rogério Mistro Piccinin

    2006-12-01

    Full Text Available Descrição do caso de um paciente masculino de 22 anos de idade, cor parda, com decréscimo da acuidade visual em olho esquerdo e com diagnóstico de tumor testicular e metástases para pulmão e rim. Avaliação da evolução da lesão coroideana compatível com metástase ocular de tumor testicular por meio de exame oftalmológico e ecográfico. Houve resolução da lesão intra-ocular juntamente com melhora radiológica pulmonar após quimioterapia durante aproximadamente 4 meses de acompanhamento. Apesar da remissão da lesão ocular, o paciente faleceu por complicações decorrentes de metástase cerebral. Abordada na literatura como rara, não foi encontrado qualquer relato de caso sobre a metástase de coróide com sítio testicular, sendo esta, talvez, sua primeira descrição.Description of a male patient case, 22 years old, presenting visual acuity decrease in the left eye associated with the diagnosis of metastatic testicular tumor to lung and kidney. Evaluation of the evolution of a choroid lesion compatible with ocular metastasis of testis tumor through ophthalmologic and echographic examinations. There was resolution of the intraocular lesion together with lung radiologic improvement after chemotherapy during approximately 4 months of follow-up. In spite of the remission of the ocular lesion, the patient died due to complications of cerebral metastasis. Approached in the literature as rare, no report was found of a case of choroidal metastasis of a testicular site, this being, perhaps, its first description.

  15. The New England Journal of Medicine, CorSalud y las enfermedades cardiovasculares

    Directory of Open Access Journals (Sweden)

    Francisco Luis Moreno Martínez

    2012-03-01

    Full Text Available Con motivo del aniversario 200 de The New England Journal of Medicine, el colectivo de CorSalud hace llegar su felicitación a esa prestigiosa publicación médica. Queda manifiesto el importante papel que ha tenido esa revista en el incremento del conocimiento científico, específicamente en la especialidad de Cardiología; y desde luego, su calidad editorial, basadas no solo en experiencia sino también en profesionalismo, la sitúan como paradigma a seguir por todas y cada una de las revistas de la comunidad científica médica.

  16. Plexo coróide hipertrofiado (demonstrado angiogràficamente e hidrocefalia

    Directory of Open Access Journals (Sweden)

    Gilberto Machado de Almeida

    1964-12-01

    Full Text Available É discutido e mesmo pôsto em dúvida por alguns autores, o papel desempenhado pelo aumento de produção do líquido cefalorraqueano (LCR, na patogênese da hidrocefalia. No caso apresentado foram encontrados os seguintes elementos que indicam ser o aumento de produção do LCR a causa da hipertensão intracraniana: 1 hipertrofia dos plexos coróides sugerida pelas angiografias e confirmada pelo ato cirúrgico e necropsia; 2 ausência de bloqueio ao trânsito do LCR; 3 grande aumento do espaço subaracnói-deo, mais evidente ao nível das cisternas, inclusive inter-hemisférica e silviana.

  17. Functional analysis of the conserved hydrophobic gate region of the magnesium transporter CorA.

    Science.gov (United States)

    Svidová, Soňa; Sponder, Gerhard; Schweyen, Rudolf J; Djinović-Carugo, Kristina

    2011-06-01

    The Leu294 residue in the cytoplasmic neck of Thermotoga maritima CorA is considered to be the main gate for Mg2+ transport. We created three site-directed mutants at this position: in the Leu294Asp and Leu294Gly mutants we observed a defect in closing of the pore, while in the Leu294Arg mutant not only gating, but also the regulation of Mg2+ uptake was affected. Our results confirmed the importance of the Leu294 for gating of Mg2+ transport and in addition revealed the influence of the charge and structural features of the amino acid residues on the gating mechanism. Copyright © 2010 Elsevier B.V. All rights reserved.

  18. Caracterizaçao silvicultural dos tipos florestais do Parque Nacional Cerro Corá - Paraguay

    OpenAIRE

    Bogado Arrúa, Christian Santiago

    2013-01-01

    O presente trabalho de pesquisa teve por objetivo urna caracterização silvicultural de 4 tipos florestais do Parque Nacional Cerro Corá, Amarnbay/Paraguay; localizada à 22°28’S e 56°oo’W. A região apresenta clima Cfa (Köeppen). Os tipos florestais definidos na área do Parque são: Bosque Alto, Bosque Baixo, Campo Alto Arbóreo e Bosque em Galeria. Para o inventário florístico utilizou-se sub-parcelas contíguas de 100 m², colocadas em forma espiralada nos Bosque Alto, Bosque Baixo e Bosque em Ga...

  19. Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABAB and cannabinoid CB1 receptors.

    Science.gov (United States)

    Maccioni, Paola; Colombo, Giancarlo; Lorrai, Irene; Zaru, Alessandro; Carai, Mauro A M; Gessa, Gian Luigi; Brizzi, Antonella; Mugnaini, Claudia; Corelli, Federico

    2017-05-24

    COR659 [methyl2-(4-chlorophenylcarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate] is a new, positive allosteric modulator (PAM) of the GABAB receptor. This study evaluated whether COR659 shared with previously tested GABAB PAMs the capacity to reduce alcohol self-administration in rats. Treatment with non-sedative doses of COR659 (2.5, 5, and 10 mg/kg; i.p.) suppressed lever-responding for alcohol (15% v/v) in Sardinian alcohol-preferring (sP) rats under the fixed ratio (FR) 4 (FR4) and progressive ratio (PR) schedules of reinforcement; COR659 was more potent and effective than the reference GABAB PAM, GS39783. Treatment with COR659, but not GS39783, suppressed (a) lever-responding for a sucrose solution (1-3% w/v) in sP rats under the FR4 and PR schedules, (b) lever-responding for a chocolate solution [5% (w/v) Nesquik®] in Wistar rats under the FR10 and PR schedules, and (c) cue-induced reinstatement of chocolate seeking in Wistar rats. Treatment with COR659 was completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats. Pretreatment with the GABAB receptor antagonist, SCH50911, partially blocked COR659-induced reduction of alcohol self-administration, being ineffective on reduction of chocolate self-administration. Pretreatment with the cannabinoid CB1 receptor antagonist, AM4113, fully blocked COR659-induced reduction of chocolate self-administration, being ineffective on reduction of alcohol self-administration. COR659 might exert its behavioral effects via a composite mechanism: (i) positive allosteric modulation of the GABAB receptor, responsible for a large proportion of reduction of alcohol self-administration; (ii) an action at other receptor system(s), including the cannabinoid CB1 receptor, through which COR659 affects seeking and consumption of highly palatable foods.

  20. CorSalud, The New England Journal of Medicine, and the International Committee of Medical Journal Editors

    Directory of Open Access Journals (Sweden)

    Francisco L. Moreno-Martínez

    2016-06-01

    Full Text Available CorSalud y The New England Journal of Medicine (NEJM coincidieron por primera vez en el título de una carta al editor en 20121, en esa ocasión fue para felicitar a tan prestigiosa revista por el bicentenario de su creación.

  1. Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations

    NARCIS (Netherlands)

    Rudi, Katharina; Ho, Franz Y; Gilsbach, Bernd Karl; Pots, Henderikus; Wittinghofer, Alfred; Kortholt, Arjan; Klare, Johann P

    2015-01-01

    Ras of complex proteins (Roc) is a Ras-like GTP binding domain that always occurs in tandem with the C-terminal of Roc (COR) domain, and is found in bacteria, plants and animals. Recently, it has been shown that Roco proteins belong to the family of G-proteins activated by nucleotide-dependent dimer

  2. The Cryo-EM structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions.

    Science.gov (United States)

    Cleverley, Robert M; Kean, James; Shintre, Chitra A; Baldock, Clair; Derrick, Jeremy P; Ford, Robert C; Prince, Stephen M

    2015-10-01

    CorA channels are responsible for the uptake of essential magnesium ions by bacteria. X-ray crystal structures have been resolved for two full-length CorA channels, each in a non-conducting state with magnesium ions bound to the protein: These structures reveal a homo-pentameric quaternary structure with approximate 5-fold rotational symmetry about a central pore axis. We report the structure of the detergent solubilized Methanocaldococcus jannaschii CorA channel determined by Cryo-Electron Microscopy and Single Particle Averaging, supported by Small Angle X-ray Scattering and X-ray crystallography. This structure also shows a pentameric channel but with a highly asymmetric domain structure. The asymmetry of the domains includes differential separations between the trans-membrane segments, which reflects mechanical coupling of the cytoplasmic domain to the trans-membrane domain. This structure therefore reveals an important aspect of the gating mechanism of CorA channels by providing an indication of how the absence of magnesium ions leads to major structural changes. Copyright © 2015. Published by Elsevier B.V.

  3. L’archipel nord-coréen: transition économique et blocages territoriaux

    Directory of Open Access Journals (Sweden)

    César Ducruet

    2007-09-01

    Full Text Available L’une des caractéristiques récentes de la Corée du Nord est le manque manifeste d’intégration territoriale, en contradiction croissante avec la volonté d’ouverture économique. Dans un environnement mondialisé, le faible coût et la qualité de sa main-d’œuvre, l’abondance des ressources naturelles, et une situation stratégique entre la Corée du Sud, le Japon et leurs voisins continentaux immédiats comme la Chine et la Russie, sont autant d’atouts qui devraient permettre la mise en œuvre des réformes et la relance de l’économie. Tandis que la plupart des travaux précédents se basent sur les facteurs politiques externes pour expliquer les difficultés rencontrées (isolement dû à la disparition du bloc de l’Est, embargo imposé par les États-Unis et le Japon, cet article privilégie les facteurs spatiaux internes. L’examen successif de structures spatiales fondamentales montre que la déconnexion croissante entre les différentes provinces, conséquence d’un long déclin économique et de la dégradation des infrastructures, serait une contrainte majeure avec laquelle les projets de développement du pays sont confrontés, au-delà des aspects purement politiques.

  4. Probing structure-function relationships and gating mechanisms in the CorA Mg2+ transport system.

    Science.gov (United States)

    Payandeh, Jian; Li, Canhui; Ramjeesingh, Mohabir; Poduch, Ewa; Bear, Christine E; Pai, Emil F

    2008-04-25

    Recent crystal structures of the CorA Mg(2+) transport protein from Thermotoga maritima (TmCorA) revealed an unusually long ion pore putatively gated by hydrophobic residues near the intracellular end and by universally conserved asparagine residues at the periplasmic entrance. A conformational change observed in an isolated funnel domain structure also led to a proposal for the structural basis of gating. Because understanding the molecular mechanisms underlying ion channel and transporter gating remains an important challenge, we have undertaken a structure-guided engineering approach to probe structure-function relationships in TmCorA. The intracellular funnel domain is shown to constitute an allosteric regulatory module that can be engineered to promote an activated or closed state. A periplasmic gate centered about a proline-induced kink of the pore-lining helix is described where "helix-straightening" mutations produce a dramatic gain-of-function. Mutation to the narrowest constriction along the pore demonstrates that a hydrophobic gate is operational within this Mg(2+)-selective transport protein and likely forms an energetic barrier to ion flux. We also provide evidence that highly conserved acidic residues found in the short periplasmic loop are not essential for TmCorA function or Mg(2+) selectivity but may be required for proper protein folding and stability. This work extends our gating model for the CorA-Alr1-Mrs2 superfamily and reveals features that are characteristic of an ion channel. Aspects of these results that have broader implications for a range of channel and transporter families are highlighted.

  5. A Clinical and Follow-up Study of Right and Left Bundle Branch Block

    Science.gov (United States)

    1974-09-03

    acute myocardial infarction and one with chronic !ung disease and cor pulmonale ). Of the nine BBBB subjects with an initial diagnosis of hyperten...complicated In cor pulmonale . and for one, the cause of death was not available. Of the nine LBBB patients who died, five died of conditions related...the RBBB group, i and 2’r had cor - onarx heart disease and hypertension, respectively; in LBBB subjects, 9 and ~’i had coronarv heart disease and h

  6. Regional CORS Coordinates Time Series Cycle Characteristics Analysis%区域 CORS 网坐标时间序列周期特征分析

    Institute of Scientific and Technical Information of China (English)

    黄焱; 田林亚; 孙腾科; 马丙浩

    2015-01-01

    通过精密单点定位的方法获取了区域CORS网各基准站的坐标时间序列,并利用最大似然估计法和频谱分析法对其32个基准站坐标时间序列的周期特征进行了分析,获取了各基准站年周期、半年周期的振幅和相位值,以及各基准站的周期功率谱图。结果表明:GNSS基准站坐标时间序列不仅存在线性变化,还存在周期性变化,其中以U方向表征最为明显,与双差定位获得的坐标时间序列周期特性分析结果一致,说明以精密单点定位获取的GNSS基准站坐标时间序列是可靠的,可以用来分析基准站的变化特征。%For four years 32 evenly distributed GNSS station data of regional CORS processing, obtained the coordinate time series of each station by the method of PPP( precise point positioning) , then using the method of maximum likelihood estimate and spectrum a-nalysis to process the coordinate time series of 32 stations, obtained the amplitude of year and half-year cycle and phase value of each station, as well as power spectrum diagram.The results showed that:the coordinate time series of GNSS stations not only exist linear characteristics, but also cycle characteristics, each station has cycle change of year and half-year at N, E, U, and vertical di-rection has the most obvious year cycle characteristics, this is same as the results of double difference positioning, so the coordinate time series of GNSS stations by the method of PPP is reliable, they can use to analysis the change characteristics of GNSS station.

  7. Termoterapia transpupilar em melanoma maligno da coróide Transpupillary thermotherapy for malignant choroidal melanoma

    Directory of Open Access Journals (Sweden)

    Martha M. Motomo Chojniak

    2001-04-01

    Full Text Available Objetivo: Vários métodos vem sendo utilizados para o tratamento dos melanomas da coróide. A proposta deste trabalho preliminar é avaliar a eficácia da termoterapia transpupilar (TTT como tratamento primário de melanomas da coróide pequenos. Métodos: Foi realizado um trabalho prospectivo e não-randomizado para avaliar os aspectos clínicos, resposta do tumor, complicações e resultados visuais de pacientes portadores de melanomas da coróide pequenos (até 4,0 mm de espessura e 12 mm de diâmetro basal tratados por termoterapia transpupilar utilizando-se sucessivas aplicações de laser diodo contínuo de 810 nm. Resultados: Foram tratados 11 pacientes portadores de melanomas da coróide pequenos. O tumor era único e pigmentado em 100% dos casos. Crescimento documentado esteve presente em 5 pacientes (45,45% previamente ao tratamento e fatores de risco para crescimento ou metástase estavam presentes em todos os pacientes. O tempo de seguimento destes pacientes a partir do tratamento foi em média de 5,72 meses (3 - 8 meses. Foram utilizadas 3 sessões de laser em 5 pacientes (45,45% e 4 sessões em 6 pacientes (64,64%. As lesões apresentavam, por ocasião do diagnóstico, uma espessura média de 2,65 mm (1,85-3,86 mm, com maior diâmetro basal médio de 7,98 mm (4,2-11,33 mm. Após o tratamento, a espessura média foi de 1,83 mm (0,98-2,93 mm e o maior diâmetro basal médio foi de 6,59 mm (3,81 mm -10,67 mm. Das lesões tratadas, 100% apresentaram diminuição da altura e do máximo diâmetro basal, tendo sido a diminuição média da espessura de 0,89 mm e do máximo diâmetro basal de 1,39 mm. A acuidade visual manteve-se inalterada em 5 casos (45,45% e piorou após o tratamento em 6 casos (54,54%. Ocorreram complicações em 9 casos, tendo sido considerada complicação grave 1 caso de descolamento parcial da retina (9,09%; as outras complicações foram consideradas leves: pequenas hemorragias intra-retinianas em 7 pacientes (63

  8. CorA affects tolerance of Escherichia coli and Salmonella enterica serovar Typhimurium to the lactoperoxidase enzyme system but not to other forms of oxidative stress.

    Science.gov (United States)

    Sermon, Jan; Wevers, Eva M-R P; Jansen, Leentje; De Spiegeleer, Philipp; Vanoirbeek, Kristof; Aertsen, Abram; Michiels, Chris W

    2005-11-01

    The enzyme lactoperoxidase is part of the innate immune system in vertebrates and owes its antimicrobial activity to the formation of oxidative reaction products from various substrates. In a previous study, we have reported that, with thiocyanate as a substrate, the lactoperoxidase system elicits a distinct stress response in Escherichia coli MG1655. This response is different from but partly overlapping with the stress responses to hydrogen peroxide and to superoxide. In the current work, we constructed knockouts in 10 lactoperoxidase system-inducible genes to investigate their role in the tolerance of E. coli MG1655 to this antimicrobial system. Five mutations resulted in a slightly increased sensitivity, but one mutation (corA) caused hypersensitivity to the lactoperoxidase system. This hypersensitive phenotype was specific to the lactoperoxidase system, since neither the sensitivity to hydrogen peroxide nor to the superoxide generator plumbagin was affected in the corA mutant. Salmonella enterica serovar Typhimurium corA had a similar phenotype. Although corA encodes an Mg2+ transporter and at least three other inducible open reading frames belonged to the Mg2+ regulon, repression of the Mg stimulon by Mg2+ did not change the lactoperoxidase sensitivity of either the wild-type or corA mutant. Prior exposure to 0.3 mM Ni2+, which is also transported by CorA, strongly sensitized MG1655 but not the corA mutant to the lactoperoxidase system. Furthermore, this Ni2+-dependent sensitization was suppressed by the CorA-specific inhibitor Co(III) hexaammine. These results indicate that CorA affects the lactoperoxidase sensitivity of E. coli by modulating the cytoplasmic concentrations of transition metals that enhance the toxicity of the lactoperoxidase system.

  9. Desigualdades sociais e tuberculose: analise segundo raca/cor, Mato Grosso do Sul

    Directory of Open Access Journals (Sweden)

    Paulo Cesar Basta

    2013-10-01

    Full Text Available OBJETIVO Analisar características sociodemográficas e clínico-epidemiológicas dos casos de tuberculose e fatores associados ao abandono e ao óbito na vigência do tratamento. MÉTODOS Estudo epidemiológico baseado em dados notificados de tuberculose em indígenas e não indígenas, segundo raça/cor, em Mato Grosso do Sul, entre 2001 e 2009. Realizou-se análise descritiva dos casos de acordo com as variáveis sexo, faixa etária, zona de residência, exames empregados para o diagnóstico, forma clínica, tratamento supervisionado e situação de encerramento, segundo raça/cor. Utilizou-se análise univariada e múltipla por meio de regressão logística para identificar preditores de abandono e óbito, e odds ratio como medida de associação. Foi construída série histórica de incidência, segundo raça/cor. RESULTADOS Registraram-se 6.962 casos novos de tuberculose no período, 15,6% entre indígenas. Houve predomínio em homens e adultos (20 a 44 anos em todos os grupos. A maior parte dos doentes indígenas residia na zona rural (79,8% e 13,5% dos registros nos indígenas ocorreram em 45 anos (OR = 3,0; IC95% 1,2;7,8 e com a forma mista (OR = 2,3; IC95% 1,1;5,0 apresentaram associação com óbito. Apesar de representarem 3,0% da população, os indígenas foram responsáveis por 15,6% das notificações no período. CONCLUSÕES Houve importantes desigualdades em relação ao adoecimento por tuberculose entre as categorias estudadas. As incidências nos indígenas foram consistentemente maiores, chegando a exceder em mais de seis vezes as médias nacionais. Entre pretos e pardos, piores resultados no tratamento foram observados, pois apresentaram chance de abandono duas vezes maior que os indígenas. O mau desempenho do programa também esteve fortemente associado ao abandono e ao óbito. Acredita-se que, enquanto não se reduzir a pobreza, as desigualdades nos indicadores em saúde permanecerão.

  10. Fotografia e cor: os esquemas de combinações de cores conduzindo a construção e leitura de fotografias

    OpenAIRE

    Egashira, Rafael

    2013-01-01

    Este trabalho buscou apresentar uma experiência fotográfica vivenciada pelo autor desta dissertação que fosse conduzida pela teoria da cor. Foi assumido que a fotografia colorida é uma construção dupla, no sentido de que tanto a fotografia como a cor não são neutras. Para embasar esse pressuposto, introduzimos elementos da teoria da fotografia que refutam o automatismo do aparelho fotográfico e trouxemos conceitos da teoria da cor que definem a percepção cromática como um fenômeno que envolve...

  11. COR, a new adaptive radiotherapy technique using conical tomography and offline re-planning; COR, une nouvelle technique de radiotherapie adaptative utilisant la tomographie conique et la replannification offline

    Energy Technology Data Exchange (ETDEWEB)

    Octave, N.; Beaulieu, L. [Departement de physique, de genie physique et d' optique, universite Laval, Quebec (Canada); Boutry, C.; Dudouet, P. [Groupe Oncorad Garonne, service de radiotherapie, clinique du Pont-de-Chaume, 82 - Montauban (France); Octave, N.; Gingras, L.; Beaulieu, L. [Departement de radio-oncologie, centre de recherche en cancerologie, CHU de Quebec (Canada); Berry, I. [Biophysique et medecine nucleaire, CHU de Toulouse Rangueil, 31 - Toulouse (France); Octave, N.; Berry, I. [Universite Paul-Sabatier, Toulouse 3, 31 - Toulouse (France)

    2010-10-15

    The authors present a new adaptive radiotherapy technique which uses daily conical (or dual-axis) tomographies. For each fraction of prostatic intensity modulated and conformational radiotherapy (RCMI), conical tomographies are acquired and used to reposition the patient and to generate a new optimized RCMI plan. Three therapeutic strategies are then elaborated and studied: a conventional strategy (the patient is totally treated with a dosimetry based of the initial scanography), an optimal strategy (the patient is treated on a daily basis with the optimized RCMI plan based on the conical tomography), and a Continuous Offline Re-planning (COR) strategy which uses the whole set of plans computed on the conical tomographies performed on the day before the treatment. The obtained results show that the COR strategy leads to a better dosimetric coverage and to less severe technical and human constraints. Short communication

  12. Computation of Estonian CORS data using Bernese 5.2 and Gipsy 6.4 softwares

    Science.gov (United States)

    Kollo, Karin; Kall, Tarmo; Liibusk, Aive

    2017-04-01

    GNSS permanent station network in Estonia (ESTREF) was established already in 2007. In 2014-15 extensive reconstruction of ESTREF was carried out, including the establishment of 18 new stations, change of the hardware in CORS stations as well as establishing GNSS-RTK service for the whole Estonia. For GNSS-RTK service one needs precise coordinates in well-defined reference frame, i.e., ETRS89. For long time stability of stations and time-series analysis the re-processing of Estonian CORS data is ongoing. We re-process data from 2007 until 2015 with program Bernese GNSS 5.2 (Dach, 2015). For the set of ESTREF stations established in 2007, we perform as well computations with GIPSY 6.4 software (Ries et al., 2015). In the computations daily GPS-only solution was used. For precise orbits, final products from CODE (CODE analysis centre at the Astronomical Institute of the University of Bern) and JPL (Jet Propulsion Laboratory) for Bernese and GIPSY solutions were used, respectively. The cut-off angle was set to 10 degrees in order to avoid near-field multipath influence. In GIPSY, precise point positioning method with fixing ambiguities was used. Bernese calculations were performed based on double difference processing. Antenna phase centers were modelled based on igs08.atx and epnc_08.atx files. Vienna mapping function was used for mapping tropospheric delays. For the GIPSY solution, the higher order ionospheric term was modelled based on IRI-2012b model. For the Bernese solution higher order ionospheric term was neglected. FES2004 ocean tide loading model was used for the both computation strategies. As a result, two solutions using different scientific GNSS computation programs were obtained. The results from Bernese and GIPSY solutions were compared, using station repeatability values, RMS and coordinate differences. KEYWORDS: GNSS reference station network, Bernese GNSS 5.2, Gipsy 6.4, Estonia. References: Dach, R., S. Lutz, P. Walser, P. Fridez (Eds); 2015

  13. Endocardial cushion defect associated with cor triatriatum sinistrum or supravalve mitral ring.

    Science.gov (United States)

    Thilenius, O G; Vitullo, D; Bharati, S; Luken, J; Lamberti, J J; Tatooles, C; Lev, M; Carr, I; Arcilla, R A

    1979-12-01

    Clinical and angiographic or autopsy data, or both, on three children with a subdivided left atrium (cor triatriatum) and an associated endocardial cushion defect are reviewed. (One child had ostium primum defect, and two had complete atrioventricular [A-V] canal.) A fourth patient demonstrates the difficulties in differentiating subdivided left atrium from supravalve mitral stenosis in the presence of an endocardial cushion defect. The clinical findings are greatly influenced by the endocardial cushion defect. A pressure gradient between the pulmonary wedge and (left or right) ventricular end-diastolic pressures in patients with an endocardial cushion defect indicates pulmonary venous obstruction and should alert one to the possibility of these combined lesions. The exact diagnosis is made with injections of angiographic contrast medium into the proximal and distal left atrial chambers, to documented the respective relations of the pulmonary veins, left atrial appendage and A-V valves to these atrial chambers. All three patients with an endocardial cushion defect and a subdivided left atrium had an associated patent ductus arteriosus. The common association of subdivided left atrium with intracardiac, pulmonary venous and aortic anomalies is again demonstrated.

  14. Cor triatriatum izquierdo diagnosticado tardíamente. Reporte de caso

    Directory of Open Access Journals (Sweden)

    Francisco J. Vázquez-Roque

    2016-09-01

    Full Text Available El Cor Triatriatum izquierdo es una anomalía congénita cardiaca rara. Es infrecuente que estos pacientes sobrepasen la edad de 40 años sin su corrección quirúrgica. El objetivo de este artículo fue el de presentar un paciente de 43 años que fue intervenido quirúrgicamente a la edad de 5 años para el cierre de una comunicación interauricular y donde el diagnóstico de esta entidad no se realizó. Un mes antes del ingreso comienza con palpitaciones y disnea a los moderados esfuerzos. Con la ecografía transesofágica se hace el diagnóstico de esta anomalía, la cual se asociaba a una insuficiencia mitral y fibrilación auricular. Se procedió a la resección de la membrana fibromuscular y la reparación de dos hendiduras congénitas en el borde del velo anterior de la válvula mitral con buenos resultados. Un año después el paciente se encuentra asintomático y en la ecocardiografía transtoráxica se muestra una aurícula izquierda unicameral con una regurgitación mitral trivial.

  15. Cor Triatriatum Sinister Identified after New Onset Atrial Fibrillation in an Elderly Man

    Directory of Open Access Journals (Sweden)

    Ignacio A. Zepeda

    2014-01-01

    Full Text Available A 73-year-old man with new onset atrial fibrillation with rapid ventricular response underwent transthoracic echocardiography that revealed an echogenic linear structure along the left atrium, suggestive of cor triatriatum sinister (CTS. CTS was confirmed with transesophageal echocardiography which demonstrated a proximal accessory atrium receiving pulmonary venous flow separated from a distal true atrium by a fibromuscular membrane with a large fenestration allowing flow between the chambers. In CTS, the left atrium is divided into proximal and distal chambers by a fenestrated fibromuscular septum. This cardiac anomaly accounts for 0.1% of cases of congenital heart disease and rarely presents in adults. CTS is primarily diagnosed with echocardiography and is associated with left atrial enlargement and development of atrial fibrillation. Treatment options depend on size of the communication between proximal and distal chambers, the gradient across the membrane, and the position of pulmonary veins. In some instances, surgical resection of the membrane that divides the left atrium is warranted.

  16. Central Java Southern part area deformation analysis by using GPS-CORS 2015

    Science.gov (United States)

    Yusfania, Meiriska; Anjasmara, Ira Mutiara; Hadi, Avrilina Luthfil; Pramudya, Bima

    2017-07-01

    Indonesia located on the convergence area of four active tectonic plates. Eurasia plate collides with Indo-Australia plate which forms subduction zone at the south of Java Island and forms the java island. Indo-Australia plate moving north by 7cm/year subducting under tectonic plate of Eurasia that relatively stated. As the results, tectonics and volcanic earthquakes are commonly occured at the boundary. In 2006, 5.9 Richter's scale earthquake, took place in Jogjakarta its surrounding, causing severe damage to the infrastructures. Therefore, Central Java has been marked as the seventh area which has high possibilities of earthquake in Indonesia. The aim of this research is to investigate deformation that happened at the South of Central Java using data of Continously Operating Reference Station of Indonesia (Ina-CORS) from 2013-2015. The deformation result is represented in the form of vectors and shifting velocity. Based on the result, it can be analysed that all six stations observed have the similar moving direction that is to the southeast with the horisontal velocity valued from 0.00910 to 0.01203 m/year. The vertical velocity of six stasions range from -0.01147 to 0.04354 m/year. From strain calculation using triangle segment it is found thet the value of compression bigger than extention value. Dominant extention value is in CSLO-CMGL-CBTL segment. The Value ɛ1: 0.01879 μstrain and ɛ2: -0.00997μstrain

  17. Comparing RTK positioning from updated REGAM and MERISTEMUM CORS networks in Southeast Spain

    Science.gov (United States)

    Giménez, Elena; Selmira Garrido, Ma; de Lacy, Ma Clara; Gil, Antonio J.

    2011-05-01

    For many countries, regional networks of Continuously Operating Reference Station (CORS) are the basic infrastructure to support the needs of users requiring positioning with centimeter-scale accuracy. However, nationwide NRTK (RTK Network) coverage is often not economically viable for countries with large rural regions. In contrast, for administrative reasons and social proximity sometimes several networks may cover the same territory. Reference station placement affects the quality of the positioning services and the cost of the network. Spain has a high density of regional NRTK networks. Indeed, the Region of Murcia has two such networks: REGAM and MERISTEMUM. REGAM uses the MAC (Master Auxiliary Concept) and MERISTEMUM uses the VRS (Virtual Reference Station), which are currently the most commonly used approaches to generate network RTK corrections. Control tests based on simultaneous determination of position have been performed in the Region of Murcia to analyze the performance of the REGAM and MERISTEMUM networks. The results confirm that both the VRS and MAC network solutions provide centimeter-scale accuracy: the positioning error for the test points inside the NRTK cells is lesser than 1.5 cm in planimetry and around 3.5 cm in height. The ambiguity resolution, the coverage and the connection to the networks services were highly satisfactory.

  18. Anatomia microcirúrgica da artéria coróidea anterior

    Directory of Open Access Journals (Sweden)

    Adelmo Ferreira

    1990-12-01

    Full Text Available São apresentadas as características anatômicas da artéria coróidea anterior (AChA, encontradas nas dissecações de 100 hemisférios cerebrais de cadáveres humanos, realizadas sob microscópio cirúrgico. Foi encontrada uma AChA por hemisfério cerebral, 98% originando-se da artéria carótida interna (ACI 2,4mm distai à origem da artéria comunicante posterior (ACoP e 4,7mm proximal à bifurcação da ACI. Em 29% dos hemisférios havia ramos perfurantes emergindo da porção comunicante da ACI. A média do calibre da AChA foi 0,9mm na sua porção cisternal e 0,7mm na porção plexal. Os ramos mais freqüentes da porção cisterna da AChA foram para o trato óptico, pedúnculo cerebral, uncus e corpo geniculado lateral. Foram observadas anastomoses de ramos da AChA com ramos da artéria cerebral posterior, ACoP, artéria cerebral média e ACI. Os resultados são comparados àqueles da literatura.

  19. Sobre o uso da variável raça-cor em estudos quantitativos

    Directory of Open Access Journals (Sweden)

    Jerônimo Oliveira Muniz

    2010-06-01

    Full Text Available A crescente inclusão da raça no debate público brasileiro, o aumento da sua disponibilidade em pesquisas de opinião e monitoramento e a facilidade de inclusão da variável em modelos estatísticos tem provocado um paradoxo na importância da raça. Ao mesmo tempo em que a cor da pele vem ganhando relevância no debate político, ela também vem perdendo a sua importância substantiva como um construto social complexo e dinâmico por ser utilizada de modo superficial, como uma categoria permanente e imutável em estudos quantitativos. Este ensaio bibliográfico discorre sobre os fatores que contribuem para essa tendência levando em conta a literatura nacional e internacional produzida nos últimos dez anos. Questiona-se o uso da raça em políticas públicas atentando-se para a sua confiabilidade, variabilidade e validade e discutem-se as limitações e possibilidades de uso da raça como um demarcador de diferenças. O ensaio conclui-se sugerindo uma agenda de pesquisa para aprimorar o entendimento e reduzir as incertezas associadas ao uso da variável "raça" em estudos quantitativos.

  20. Performance of InsCor and three international scores in cardiac surgery at Santa Casa de Marília.

    Science.gov (United States)

    Tiveron, Marcos Gradim; Bomfim, Helton Augusto; Simplício, Maycon Soto; Bergonso, Marcos Henriques; Matos, Milena Paiva Brasil de; Ferreira, Sergio Marques; Pelloso, Eraldo Antônio; Barros, Rubens Tofano de

    2015-01-01

    To apply and to compare the Society of Thoracic Surgery score (STS), EuroSCORE (Eurosc1), EuroSCORE II (Eurosc2) and InsCor (IS) for predicting mortality in patients undergoing to coronary artery bypass graft and/or valve surgery at the Santa Casa Marilia. The present study is a cohort. It is a prospective, observational, analytical and unicentric. We analyzed 562 consecutive patients coronary artery bypass graft and/or valve surgery, between April 2011 and June 2013 at the Santa Casa Marilia. Mortality was calculated for each patient through the scores STS, Eurosc1, Eurosc2 and IS. The calibration was calculated using the Hosmer Lemeshow test and discrimination by ROC curve. The hospital mortality was 4,6%. The calibration is generally adequate group P=0.345, P=0.765, P=0.272 and P=0.062 for STS, Eurosc1, Eurosc2, and IS respectively. The discriminatory power of STS score 0.649 (95% CI 0.529 to 0.770, P=0.012), Eurosc1 0.706 (95% CI 0.589 to 0.823, P ≤0.001), Eurosc2 was 0.704 (95% CI 0.590-0.818 P=0.001) and InsCor 0.739 (95% CI 0.638 to 0.839, P ≤0.001). We can say that overall, the InsCor was the best model, mainly in the discrimination of the sample. The InsCor showed good accuracy, in addition to being effective and easy to apply, especially by using a smaller number of variables compared to the other models.

  1. Inner and Outer Coordination Shells of Mg(2+) in CorA Selectivity Filter from Molecular Dynamics Simulations.

    Science.gov (United States)

    Kitjaruwankul, Sunan; Wapeesittipan, Pattama; Boonamnaj, Panisak; Sompornpisut, Pornthep

    2016-01-28

    Structural data of CorA Mg(2+) channels show that the five Gly-Met-Asn (GMN) motifs at the periplasmic loop of the pentamer structure form a molecular scaffold serving as a selectivity filter. Unfortunately, knowledge about the cation selectivity of Mg(2+) channels remains limited. Since Mg(2+) in aqueous solution has a strong first hydration shell and apparent second hydration sphere, the coordination structure of Mg(2+) in a CorA selectivity filter is expected to be different from that in bulk water. Hence, this study investigated the hydration structure and ligand coordination of Mg(2+) in a selectivity filter of CorA using molecular dynamics (MD) simulations. The simulations reveal that the inner-shell structure of Mg(2+) in the filter is not significantly different from that in aqueous solution. The major difference is the characteristic structural features of the outer shell. The GMN residues engage indirectly in the interactions with the metal ion as ligands in the second shell of Mg(2+). Loss of hydrogen bonds between inner- and outer-shell waters observed from Mg(2+) in bulk water is mostly compensated by interactions between waters in the first solvation shell and the GMN motif. Some water molecules in the second shell remain in the selectivity filter and become less mobile to support the metal binding. Removal of Mg(2+) from the divalent cation sensor sites of the protein had an impact on the structure and metal binding of the filter. From the results, it can be concluded that the GMN motif enhances the affinity of the metal binding site in the CorA selectivity filter by acting as an outer coordination ligand.

  2. Parametros de cor e turbidez como indicadores de impactos resultantes do uso do solo, na bacia hidrografica do Rio Taquaral, Sao Mateus Do Sul--PR

    National Research Council Canada - National Science Library

    Ewerling Luiz, Angela Marli; Cassol Pinto, Maria Ligia; Weinhardt de Oliveira Scheffer, Elizabeth

    2012-01-01

    O abastecimento humano exige agua com qualidade. Nesse sentido, o presente artigo teve por objetivo relacionar aspectos fisicos e de uso do solo com os parametros aquaticos de cor e turbidez do Rio Taquaral, Sao Mateus do Sul...

  3. Characterization of a CorA Mg2+ transport channel from Methanococcus jannaschii using a Thermofluor-based stability assay.

    Science.gov (United States)

    Kean, James; Cleverley, Robert M; O'Ryan, Liam; Ford, Robert C; Prince, Stephen M; Derrick, Jeremy P

    2008-12-01

    The Thermofluor assay has been a valuable asset in structural genomics, providing a high-throughput method for assessing the crystallizability of proteins. The technique has been well characterized for soluble proteins but has been less extensively described for membrane proteins. Here we show the successful application of a Thermofluor-based stability assay to an ion channel, CorA from Methanococcus jannaschii. Optimization of the concentration of free detergent within the assay was important, as excessive concentrations mask the fluorescence change associated with thermal unfolding of the protein. CorA was shown to be stabilized by low pH, but relatively insensitive to salt concentration. Divalent metal cations were also capable of stabilizing the protein, in the order Co2+>Ni2+>Mn2+>Mg2+>Ca2+. Finally, removal of the oligohistidine tag was also shown to improve the thermal stability of CorA. Conclusions are drawn from this detailed study about the general applicability of this technique to other membrane proteins.

  4. Why is the GMN motif conserved in the CorA/Mrs2/Alr1 superfamily of magnesium transport proteins?

    Science.gov (United States)

    Palombo, Isolde; Daley, Daniel O; Rapp, Mikaela

    2013-07-16

    Members of the CorA/Mrs2/Alr1 superfamily of transport proteins mediate magnesium uptake in all kingdoms of life. Family members have a low degree of sequence conservation but are characterized by a conserved extracellular loop. While the degree of sequence conservation in the loop deviates to some extent between family members, the GMN family signature motif is always present. Structural and functional data imply that the loop plays a central role in magnesium selectivity, and recent biochemical data suggest it is crucial for stabilizing the pentamer in the magnesium-free (putative open) conformation. In this study, we present a detailed structure-function analysis of the extracellular loop of CorA from Thermotoga maritima, which provides molecular insight into how the loop mediates these two functions. The data show that loop residues outside of the GMN motif can be substituted if they support the pentameric state, but the residues of the GMN motif are intolerant to substitution. We conclude that G(312) is absolutely required for magnesium uptake, M(313) is absolutely required for pentamer integrity in the putative open conformation, and N(314) plays a role in both of these functions. These observations suggest a molecular reason why the GMN motif is conserved throughout the CorA/Mrs2/Alr1 superfamily.

  5. The mechanisms of Mg2+ and Co2+ transport by the CorA family of divalent cation transporters.

    Science.gov (United States)

    Guskov, Albert; Eshaghi, Said

    2012-01-01

    The metal ions Mg(2+) and Co(2+) are essential for life, although to different degree. They have similar chemical and physical properties, but their slight differences result in Mg(2+) to be the most abundant metal ion in living cells and the trace element Co(2+) being toxic at relatively low concentrations. Specialized transporters have evolved in living cells to supply and balance the Mg(2+) and Co(2+) need of the cells. The current knowledge of the molecular mechanisms of Mg(2+) and Co(2+) -specific transporters is very limited at this point. Recently, there has been remarkable advances to understand the CorA family, a family of transporters that are able to transport both ions. These new data have increased our insights in how Mg(2+) and Co(2+) are translocated across membranes. Presently, CorA is probably the best system to study the mechanisms of Mg(2+) and Co(2+) transport. This chapter discusses the mechanisms through which CorA selects, transports, and regulates the translocation of its substrate. In addition, we highlight the physical and chemical properties of the substrates, which are important parameters required for better understanding of the transporter action. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. StreptInCor: a candidate vaccine epitope against S. pyogenes infections induces protection in outbred mice.

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    Edilberto Postol

    Full Text Available Infection with Streptococcus pyogenes (S. pyogenes can result in several diseases, particularly in children. S. pyogenes M protein is the major virulence factor, and certain regions of its N-terminus can trigger autoimmune sequelae such as rheumatic fever in susceptible individuals with untreated group A streptococcal pharyngitis. In a previous study, we utilized a large panel of human peripheral blood cells to define the C-terminal protective epitope StreptInCor (medical identity, which does not induce autoimmune reactions. We recently confirmed the results in HLA-transgenic mice. In the present study, we extended the experimental assays to outbred animals (Swiss mice. Herein, we demonstrate high titers of StreptInCor-specific antibodies, as well as appropriate T-cell immune responses. No cross-reaction to cardiac myosin was detected. Additionally, immunized Swiss mice exhibited 87% survival one month after challenge with S. pyogenes. In conclusion, the data presented herein reinforce previous results in humans and animals and further emphasize that StreptInCor could be an effective and safe vaccine for the prevention of S. pyogenes infections.

  7. Using residual stacking to mitigate site-specific errors in order to improve the quality of GNSS-based coordinate time series of CORS

    Science.gov (United States)

    Knöpfler, Andreas; Mayer, Michael; Heck, Bernhard

    2014-05-01

    Within the last decades, positioning using GNSS (Global Navigation Satellite Systems; e.g., GPS) has become a standard tool in many (geo-) sciences. The positioning methods Precise Point Positioning and differential point positioning based on carrier phase observations have been developed for a broad variety of applications with different demands for example on accuracy. In high precision applications, a lot of effort was invested to mitigate different error sources: the products for satellite orbits and satellite clocks were improved; the misbehaviour of satellite and receiver antennas compared to an ideal antenna is modelled by calibration values on absolute level, the modelling of the ionosphere and the troposphere is updated year by year. Therefore, within processing of data of CORS (continuously operating reference sites), equipped with geodetic hardware using a sophisticated strategy, the latest products and models nowadays enable positioning accuracies at low mm level. Despite the considerable improvements that have been achieved within GNSS data processing, a generally valid multipath model is still lacking. Therefore, site specific multipath still represents a major error source in precise GNSS positioning. Furthermore, the calibration information of receiving GNSS antennas, which is for instance derived by a robot or chamber calibration, is valid strictly speaking only for the location of the calibration. The calibrated antenna can show a slightly different behaviour at the CORS due to near field multipath effects. One very promising strategy to mitigate multipath effects as well as imperfectly calibrated receiver antennas is to stack observation residuals of several days, thereby, multipath-loaded observation residuals are analysed for example with respect to signal direction, to find and reduce systematic constituents. This presentation will give a short overview about existing stacking approaches. In addition, first results of the stacking approach

  8. Effect of facial mask ventilation treatment on plasma concentration of BNP and ET-1 in cor pulmonale patients with respiratory failure%FMV对肺心病并发呼吸衰竭患者BNP和ET-1水平的影响

    Institute of Scientific and Technical Information of China (English)

    殷少军; 吕中伟; 傅佩芳; 张国良; 颜正茂; 彭爱梅

    2009-01-01

    目的 评价面罩机械通气(facial mask ventilation,FMV)在慢性肺心病伴呼吸衰竭治疗中的临床价值及其治疗前后血浆脑钠素(brain natriuretic peptide,BNP)和内皮素-1(endothelin-1,ET-1)水平的变化.方法 慢性肺心病伴呼吸衰竭患者60例,随机分为FMV治疗组(30例)和常规治疗组(30例).常规治疗组为静脉滴注呼吸兴奋剂、降肺动脉压、强心、利尿剂等药物并加用鼻导管给氧治疗.FMV治疗组,在常规内科治疗同时加用FMV治疗,分别观察治疗72 h后2组患者心率(HR)、呼吸频率(RR)、血压、脉搏、血氧饱和度、血气分析和临床症状、体征以及血浆BNP和ET的变化.结果 与常规治疗组比较,FMV组治疗72 h后,患者临床症状与体征的改善明显,其SaO2、PaO2显著升高、PaCO2、HR、RR显著下降(P<0.05或P<0.01).FMV治疗72 h后血浆BNP和ET-1水平随缺氧的改善、二氧化碳潴留的纠正而显著降低(P<0.01),与PaO2呈显著负相关(P<0.01),与PaCO2呈显著正相关(P<0.05).结论 FMV在改善慢性肺心病呼吸衰竭患者通气功能的同时,也降低患者血浆BNP和ET-1水平,FMV对慢性肺心病呼吸衰竭患者神经内分泌的影响可能在治疗过程中发挥一定作用.

  9. 彩色室壁运动技术评价正常人及慢性肺心病患者右室收缩功能%Evaluating of Right Ventricular Systolic Function in Normal and Chronic Cor Pulmonale Patients Using Color Kinesis

    Institute of Scientific and Technical Information of China (English)

    赵丽荣; 刘彬; 白旭东; 王小丛; 于国良; 李龙云

    2003-01-01

    目的:探讨应用CK技术评价正常人及慢性肺心病患者右室收缩功能的临床价值.方法:在心尖四腔心切面,应用CK技术对20例正常人和39例慢性肺心病患者的右室各节段收缩期内膜运动幅度进行测量.将慢性肺心病分为心功能代偿期(Ⅰ组)和心功能失代偿期(Ⅱ组).结果:正常人收缩末期右室游离壁各节段间及室间隔各节段间位移幅度无显著差异,游离壁与室间隔相应节段比较,位移幅度明显大于室间隔.与对照组比较,慢性肺心病Ⅰ组、Ⅱ组游离壁各节段运动幅度均减低,Ⅱ组减低更明显.Ⅰ组室间隔运动幅度与对照组比较无显著差异.Ⅱ组运动幅度显著增加.结论:正常人右室游离壁各节段收缩期位移幅度明显大于室间隔,右室呈偏心性收缩.肺心病代偿期右室收缩功能就有损害,并且随着病情的进展,损害进一步加重.肺心病代偿期主要以压力负荷过重为主,失代偿期压力和容量负荷过重并存.CK技术能够准确、实时地反应右室收缩功能.

  10. Research about the relationship between anoxemia and HGB, GHB in patients with cor pulmonale%肺心病患者低氧血症与血红蛋白及糖化血红蛋白关系的研究

    Institute of Scientific and Technical Information of China (English)

    马明华; 张韵琴; 李玉明; 丁爱华; 李卉

    2002-01-01

    目的探讨肺心病患者低氧血症与血红蛋白(HGB)及糖化血红蛋白(GHB)间的关系.方法肺心病组50例、对照组30例,取空腹静脉血测定Glu、HGB和GHB的含量;同时采动脉血,行血气分析仪.结果肺心病组HGB显著高于对照组(P<0.01),而PaO2肺心病组显著低于对照组(P<0.01).结论肺心病患者低氧血症与HGB及GHB有显著相关性.

  11. Assessment of expelling potassium-retaining potassium diuretic in combination with expelling acid-retaining acid diuretic for cor pulmonale%排钾-保钾结合排酸-保酸利尿方案对肺心病的探讨

    Institute of Scientific and Technical Information of China (English)

    唐邦清; 黄大明; 韦建良; 黄晖; 韦干

    2004-01-01

    目的评价排钾-保钾结合排酸-保酸利尿方案对肺源性心脏病的优越性.方法191例肺源性心脏病例随机分为A组(42例)、B组(63例)、C组(86例).A组予呋塞米20 mg(或氢氯噻嗪50 mg),每日一次;B组予呋塞米20 mg(或氢氯噻嗪50 mg)、螺内酯40 mg,每日各一次;C组予呋塞米20 mg(或氢氯噻50 mg)、螺内酯40mg、乙酰唑胺250 mg,每日各一次.对比三组治疗前后K+、Na+、Cl-、pH值、HCO3-、SBE、PaCO2等指标的变化及肺性脑病的发生情况.结果治疗7日后,A组K+、Na+、Cl+均显著降低(P<0.01),pH、HCO3-、SBE和PaCO2均显著升高(P<0.01);B组Na+、Cl-均显著降低(P<0.01),pH、HCO3-、SBE和PaCO2均显著升高(P<0.01),而K+变化不显著(P>0.05);C组虽Na+仍有显著降低(P<0.05),但K+、Cl-、pH、HCO3-、SBE、PaCO2变化均不显著(P>0.05).C组肺性脑病的发生率(0%)比A组(9.5%)、B组(12.7%)显著减少(P<0.05~0.01).结论排钾-保钾结合排酸-保酸利尿方案对维持肺心病的电解质和酸碱平衡及预防肺性脑病的发生有明显优越性.

  12. Therapeutic Observation on 30 Cor pulmonale Cases with heart failure Treated with Dong-Chong-Xia-Chao%冬虫夏草辅助治疗肺原性心脏病呼吸衰竭30例疗效观察

    Institute of Scientific and Technical Information of China (English)

    杨志彬; 展春; 杜建民; 肖琅

    2002-01-01

    目的:探讨冬虫夏草治疗慢性呼吸衰竭(呼衰)的作用机制.方法:对30例肺原性心脏病(肺心病)呼衰患者在综合治疗的基础上采用冬虫夏草治疗,治疗前后进行血浆氨基酸测定并比较其变化.结果:应用冬虫夏草后除苯丙氨酸外的人体必需氨基酸均增高,患者的支链氨基酸/芳香族氨基酸(BCAA/AAA)比值明显上升.结论:冬虫夏草是通过改变血浆氨基酸,使BCAA/AAA比值上升,而对肺心病呼衰发挥辅助治疗作用.

  13. Study on serum 1,25- (OH)2D3 and metabolism of calcium、phosphorus、magnesim in patients with advanced cor pulmonale%慢性肺心病患者血1,25-(OH)2D3与钙磷镁代谢

    Institute of Scientific and Technical Information of China (English)

    王方剑; 王春丽; 王昶; 杨劲松; 黄强

    2003-01-01

    目的:探讨1,25-(OH)2D3水平改变在慢性肺心病患者钙、磷、镁代谢紊乱中的作用.方法:测定了48例该病患者血1,25-(OH)2D3和血、24h尿钙、磷、镁(SCa、SP、SMg,UCa、UP、UMg)含量及肾小管钙、磷、镁重吸收率(TRCa、TRP、TRMg).结果:1,25-(OH)2D3患者组显著低于对照组;SCa、SMg患者组显著低于对照组,SP患者组与对照组比较无显著降低;患者组UCa相对增加者占37.5%,UMg相对或绝对增加者占75.0%;TRCa相对或绝对减少者占66.7%,TRP减少者占35.4%.结论:1,25-(OH)2D3降低是该病患者钙、磷、镁代谢紊乱的重要原因.

  14. CORS TV:一种基于网络编码的P2P TV系统%CORS TV:A Network Coding Based P2P TV System

    Institute of Scientific and Technical Information of China (English)

    张志明; 杜剑; 郭瑛; 周晋; 陈震; 李军

    2011-01-01

    Network coding can achieve maximum throughput of multicast, which shows the potential to decrease playback delay of users in P2P TV system, to improve delivery ratio, and therefore to improve video quality of the whole system. In order to improve the performance of the P2P TV system,a system based on Random Linear Nework Coding (RLNC) .called CORS TV,was designed and implemented with carefully designed topology construction and data transmission. Full taking advantage of network coding and further improving the performance of P2P TV,CORS TV has a modular architecture,and each function module runs an independent thread. The system integrates Gossip protocol for topology construction,uses most-first algorithm for determining initial playback point, and employs push based transmission scheme with First Come First Served(FCFS) transmission algorithm. The experiment results validate the effectiveness of the CORS TV desiga Compared with current P2P TV systems, it has the advantages of lower redundancy ratio,higher delivery ratio and better playback quality of users.%网络编码可以实现组播的最大吞吐率,若应用于P2P TV系统,具有降低用户播放延时、提高系统有效传输率,从而提高视频质量的潜力.为了提高P2P TV系统的性能,设计并实现了一个基于随机线性网络编码的P2P TV系统——CORS TV.围绕拓扑构建和数据传输这两个关键部分,充分利用网络编码提高系统性能,CORS TV具有功能模块线程隔离的节点内部结构,集成了基于Gossip协议的拓扑构建算法,使用了最多者优先的初始播放点设置算法,并利用了基于推的数据传榆方案和先到先得式的数据传输算法.在计算机集群上的实验验证了CORS TV系统设计的正确性和有效性.与已有P2P TV系统相比,该系统具有降低冗余率、提升系统的有效传输率、改善用户视频播放质量的优势.

  15. Diagnostic work-up of pulmonary nodules. Management of pulmonary nodules detected with low-dose CT screening; Abklaerung von Lungenrundherden. Management durch Frueherkennungsuntersuchungen detektierter pulmonaler Rundherde

    Energy Technology Data Exchange (ETDEWEB)

    Wormanns, D. [Evangelische Lungenklinik Berlin, Berlin (Germany)

    2016-09-15

    . Allerdings sind die ganz ueberwiegend vorkommenden kleinen Rundherde meistens benigne. Sie sind verantwortlich fuer die sehr hohen Raten falsch positiver Testergebnisse in den Screeningstudien. Zweckmaessige Algorithmen zur diagnostischen Abklaerung von Rundherden sind zur Reduktion der falsch positiven Screeningtests und damit zur Verbesserung der Spezifitaet des Screenings notwendig. Solche Algorithmen beruhen auf einigen in diesem Artikel ausfuehrlicher dargestellten Grundprinzipien. Erstens koennen Rundherde anhand ihres Durchmessers in grosse (ueber 8 mm), wahrscheinlich maligne, und kleine (bis 8 mm), wahrscheinlich benigne Rundherde unterteilt werden. Zweitens gibt es einige die Benignitaet des Herdes praktisch beweisende CT-morphologischen Befunde. Drittens ist fuer kleine Rundherde der Nachweis von Wachstum der beste nichtinvasive Praediktor der Malignitaet und wird als Trigger fuer die weitere Abklaerung verwendet. Weiterfuehrende nichtinvasive (PET, Kontrastmitteldynamik) und invasive (verschiedene Verfahren zur zytologischen oder histologischen Diagnostik) Tests werden vorgestellt. CT-morphologisch unterschiedliche Herde (solide oder subsolide) weisen ein unterschiedliches biologisches Verhalten auf und beduerfen verschiedener Algorithmen. Fuer den deutschsprachigen Raum existiert zurzeit kein verbindlicher Algorithmus zum Management pulmonaler Rundherde, der den aktuellen Kenntnisstand abbildet. Einige internationale sowie US-amerikanische Empfehlungen werden in diesem Artikel kurz vorgestellt und daraus Schlussfolgerungen fuer den klinischen Alltag abgeleitet. (orig.)

  16. Expressão antigênica em carcinomas do plexo coróide humano: relato de dois casos

    Directory of Open Access Journals (Sweden)

    M. C. Almeida

    1990-09-01

    Full Text Available Neoplasias provenientes do epitélio de revestimento do plexo coróide são inco-muns, tendo sido descritos 6 padrões morfológicos. O padrão anaplásico, também denominado carcinoma do plexo coróide, é o de menor freqüência e pode dar metastases fora do SNC. A distinção histológica desses tumores, particularmente da variedade anaplásica, com outras neoplasias primárias e metastáticas no SNC pode ser difícil. O uso de técnicas imunocitoquimicas em parafina tem-se mostrado útil no esclarecimento das linhagens tumorais. Os papilomas do plexo coróide têm, no entanto, sido objeto de controvérsia, por sua complexa expressão antigênica. Usando a técnica de imunoperoxidase (sistema avidina-biotina-peroxidase pesquisaram-se, em dois casos da variedade anaplásica, os seguintes marcadores: proteína glial fibrilar ácida (GFAP com anticorpo monoclonal e policlonal; ceratinas de 40-50kDa, ceratinas de 60-70kDa (callus ceratina, enolase neuronal específica (NSE e proteína S-100, com anticorpos monoclonais. Os dois tumores mostraram positividade para NSE, proteína S-100 e ceratina de 40-50kDa; uma das duas neoplasias mostrou diferenciação glial, revelando positividade para GFAP tanto com anticorpo monoclonal quanto policlonal.

  17. Masculinidade, raça/cor e saúde Masculinity, race/color and health

    Directory of Open Access Journals (Sweden)

    Luís Eduardo Batista

    2005-03-01

    Full Text Available Estudos apontam que, no Brasil, os negros possuem menor escolaridade, menor salário, residem nos bairros de periferia das grandes cidades e estão excluídos de vários direitos sociais. Parte-se da hipótese de que o processo saúde, doença e morte é construído socialmente e demarcado pelo espaço social que homens e mulheres, brancos e negros, ocupam na sociedade. Este artigo analisa o perfil da mortalidade de homens brancos e negros, por meio dos registros de óbitos do Estado de São Paulo do ano de 1999. Examina as taxas de mortalidade por causa básica, reunidas por grupos de causas da CID-10, entre a raça/cor: branca e negra. O estudo evidencia que, quando se compara a taxa da mortalidade de homens negros e brancos, os negros morrem mais que os brancos. Dentre as causas de morte dos homens negros, destacam-se os óbitos por transtornos mentais (uso de álcool e outras drogas; doenças infecciosas e parasitárias (tuberculose e HIV/ Aids e causas externas (homicídio.Studies indicate that in Brazil blacks have less formal education, lower salaries, reside in peripheral neighborhoods in large urban centers and are excluded from various social rights. This study is based on the hypothesis that health, sickness, and death are socially constructed processes demarcated by the social space occupied in society by men and women, blacks and whites. This article analyses the mortality profile of black and white men as registered in the death certificates emitted by the State of São Paulo in the year 1999. Rates of mortality were analyzed according to basic causes, according to the groups of ICD-10 [The International Statistical Classification of Diseases and Related Health Problems], and to the race/color: black and white. This study indicates that when rates of mortality of black and white men are compared, mental illnesses (alcoholism and drug addiction; infectious and parasitic diseases (tuberculoses and HIV/Aids as well as external causes

  18. 'PiraRoxa': cultivar de alface crespa de cor vermelha intensa 'PiraRoxa': triple red lettuce cultivar

    OpenAIRE

    Fernando César Sala; Cyro Paulino da Costa

    2005-01-01

    'PiraRoxa' é uma cultivar de alface (Lactuca sativa L.) crespa de cor vermelha intensa, resistente à Bremia lactucae, Thielaviopsis basicola e LMV, patótipo II. Foi selecionada por meio do método genealógico a partir do cruzamento entre o tipo Lolla Rossa 'RS 521998' e a cv. Gizela. Apresenta plantas grandes e vigorosas, folhas crespas, coloração vermelha intensa e brilhante. Em ensaios conduzidos no verão (2003/2004) o pendoamento da 'PiraRoxa' foi de 10 e 20 dias mais lento quando comparado...

  19. Las traducciones latinas del Corán, arma antislámica en la cristiandad medieval

    OpenAIRE

    Martínez Gázquez, José

    2005-01-01

    La Europa latina cristiana encontró en las traducciones latinas del Corán en la Edad Media un instrumento extraordinario para el conocimiento directo del Islam y un arma poderosa desde el punto de vista intelectual y religioso para la lucha contra los musulmanes The Christian Latin Europe found in the Middle Age an extraordinary instrument for the direct knowledge of the Islam and a powerful weapon from the intellectual and religious point of view for the struggle against the Muslims

  20. Influência da clorhexidina como inibidor das metaloproteinases na alteração da cor das resinas compostas

    OpenAIRE

    Chibeles, Inês Pereira

    2014-01-01

    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz Objetivo: Verificar in vitro se a clorhexidina, como inibidor das metaloproteinases, provoca alteração de cor numa resina composta. Materiais e métodos: Vinte dentes terceiros molares hígidos foram distribuídos aleatoriamente em quatro grupos de cinco dentes. Cada grupo foi restaurado com a resina composta Filtek Z100 e tratado previamente com um protocolo de sistema adesivo formando os seg...

  1. Influência da clorhexidina como inibidor das metaloproteinases na alteração da cor das resinas compostas

    OpenAIRE

    Chibeles, Inês Pereira

    2014-01-01

    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz Objetivo: Verificar in vitro se a clorhexidina, como inibidor das metaloproteinases, provoca alteração de cor numa resina composta. Materiais e métodos: Vinte dentes terceiros molares hígidos foram distribuídos aleatoriamente em quatro grupos de cinco dentes. Cada grupo foi restaurado com a resina composta Filtek Z100 e tratado previamente com um protocolo de sistema adesivo formando os seg...

  2. Primaire pulmonale hypertensie : nieuwe behandelingsmogelijkheden

    NARCIS (Netherlands)

    Madan, S; Boonstra, A.; Berger, R M

    2001-01-01

    Primary pulmonary hypertension (PPH) is a rare, progressive and life-threatening pulmonary vascular disease of unknown aetiology, which results in elevated pulmonary vascular resistance, pulmonary hypertension and eventually right ventricle failure. PPH occurs in all age groups, but most frequently

  3. CorA is a copper repressible surface-associated copper(I)-binding protein produced in Methylomicrobium album BG8.

    Science.gov (United States)

    Johnson, Kenneth A; Ve, Thomas; Larsen, Oivind; Pedersen, Rolf B; Lillehaug, Johan R; Jensen, Harald B; Helland, Ronny; Karlsen, Odd A

    2014-01-01

    CorA is a copper repressible protein previously identified in the methanotrophic bacterium Methylomicrobium album BG8. In this work, we demonstrate that CorA is located on the cell surface and binds one copper ion per protein molecule, which, based on X-ray Absorption Near Edge Structure analysis, is in the reduced state (Cu(I)). The structure of endogenously expressed CorA was solved using X-ray crystallography. The 1.6 Å three-dimensional structure confirmed the binding of copper and revealed that the copper atom was coordinated in a mononuclear binding site defined by two histidines, one water molecule, and the tryptophan metabolite, kynurenine. This arrangement of the copper-binding site is similar to that of its homologous protein MopE* from Metylococcus capsulatus Bath, confirming the importance of kynurenine for copper binding in these proteins. Our findings show that CorA has an overall fold similar to MopE, including the unique copper(I)-binding site and most of the secondary structure elements. We suggest that CorA plays a role in the M. album BG8 copper acquisition.

  4. Assessment of Corneal Biomechanical Properties by CorVis ST in Patients with Dry Eye and in Healthy Subjects

    Directory of Open Access Journals (Sweden)

    Qin Long

    2015-01-01

    Full Text Available Purpose. To investigate corneal biomechanical properties in patients with dry eye and in healthy subjects using Corneal Visualization Scheimpflug Technology (CorVis ST. Methods. Biomechanical parameters were measured using CorVis ST in 28 eyes of 28 patients with dry eye (dry eye group and 26 normal subjects (control group. The Schirmer I test value, tear film break-up time (TBUT, and corneal staining score (CSS were recorded for each eye. Biomechanical properties were compared between the two groups and bivariate correlation analysis was used to assess the relationship between biomechanical parameters and dry eye signs. Results. Only one of the ten biomechanical parameters was significantly different between the two groups. Patients in the dry eye group had significantly lower highest concavity time (HC-time (P=0.02 than the control group. Correlation analysis showed a significant negative correlation between HC-time and CSS with marginal P value (ρ=-0.39, P=0.04 in the dry eye group. Conclusions. The corneal biomechanical parameter of HC-time is reduced in dry eyes compared to normal eyes. There was also a very weak but significant negative correlation between HC-time and CSS in the dry eye group, indicating that ocular surface damage can give rise to a more compliant cornea in dry eyes.

  5. A cor na obra de Donald Judd: interação entre matéria e luz

    Directory of Open Access Journals (Sweden)

    Paloma Carvalho

    2009-06-01

    Full Text Available Visamos explicitar como a luz, que incide e se propaga sobre as superfícies internas e externas das peças de Donald Judd, foi concebida pelo artista como parte constitutiva de sua estrutura física. A cor torna-se sinônimo da superfície material nas peças de Judd: ela é substantiva, inerente, não aplicada, e sem intenções metafóricas. Acompanhamos a tendência crítica recente de encontrar um conceito inovador de cor na obra de Donald Judd, que até pouco tempo atrás era tomada como a representante máxima de um minimalismo ortodoxo, distante de todo e qualquer apelo sensível.We try to make visible how the light that touches and propagates over Donald Judd´s pieces-its internal and external surfaces-was conceived by the artist in the same way as the physical structure of these. In Donald Judd's work, color turns into a synonym of material surface. It's inherent, substantive, non-applied and without metaphorical meanings. We are following the recent critical tendency that sees a new concept of color in Donald Judd's work that until some years ago was taken as an orthodox minimalist leader, far away from any appeal to the senses.

  6. Sinéreses cromossômicas: projeto de complementaridade semiósica entre som e cor

    Directory of Open Access Journals (Sweden)

    Eufrásio Prates

    2008-11-01

    Full Text Available O trabalho de Basbaum transita, transdisciplinarmente, pelos campos da neurologia cognitiva, arte, fí­sica, matemática, tecnologia, misticismo e teosofia, trazidos à baila para compor a teia da sinestesia ontológica do cromo-som, complexo indissociável e simultâneo de som e cor, como busca de interconexões originárias entre som e cor a partir da esfera da primeiridade peirciana, da constituição mesma do fenômeno sinestésico. Palavras-chave Sinestesia, primeiridade. Abstract The work of Basbaum as a research on the originary interconnections between sound and color based upon the Peircian firstness sphere concern, the constitution of the synesthesic phenomenon itself , goes transdisciplinarly through the fields of cognitive neurology, arts, physics, mathematics, technology, mysticism and theosophy, all of them with regard to the weaving of the ontological; synesthesia of the chromosound, an indissociable and simultaneous complex ofsound and color. Keywords Synesthesic phenomenon, Peircian firstness.

  7. Carcinoma bilateral do plexo coróide operado com sucesso Bilateral carcinoma of the choroid plexus operated successfully

    Directory of Open Access Journals (Sweden)

    Gilberto M. de Almeida

    1970-06-01

    Full Text Available Os autores não encontraram na literatura caso de carcinoma bilateral do plexo coróide operado com sucesso. O trabalho consta da apresentação de uma criança de 11 anos com carcinoma dos plexos coróides nos dois ventrículos laterais. São feitas considerações a respeito das dificuldades no diagnóstico, da importância dó estudo angiográfico completo e do tratamentoA case of bilateral carcinoma of the choroid plexus is reported. Bilateral carcinoma of the choroid plexus are very rare and the authors did not find in the literature a similar case operated sucessfully. The difficulties for dignosis are discussed. The possibility exists that in other cases with bilateral tumors a complete diagnosis is impossible if angiography is performed only in one side. Therefore, it is necessary to perform a bilateral angiographic study when a tumor of the choroid plexus is suspected. The surgical treatment and the mortality rate are also discussed.

  8. Plexos coróides: estudo histopatológico em diferentes faixas etárias

    Directory of Open Access Journals (Sweden)

    Deise Regina Maffazzoni

    1986-12-01

    Full Text Available Os autores estudaram 146 casos de plexos coróides provenientes de autópsias realizadas no Departamento de Patologia da FFFCMPA, no período de janeiro de 1983 a outubro de 1984, com a finalidade de analisar as alterações histo-patológicas nas diferentes fases da vida. As idades dos pacientes estudados oscilaram de 26 semanas de vida intra-uterina a 87 anos. O estudo abrange 6 fetos, 26 recém-nascidos, 34 casos até um ano de idade, 4 de um a dois anos, 14 de 2 a 10 anos, 3 de 10 a 20 anos, 7 entre 20 a 30 anos, 14 de 30 a 40 anos, 23 de 40 a 60 anos, 12 de 60 a 80 anos e, três acima de 80 anos. A análise dos casos demonstrou diferenças quanto ao aspecto histopatológico dos plexos coróides, que variaram de células epiteliais vacuolizadas, presença de material eosinofílico no interstício - nos primeiros anos de vida - a calcificações restritas ao glomus e psamomas ou calcificações grosseiras, cuja intensidade acentuou-se com o aumento da faixa etária.

  9. Combination of cor triatriatum sinistrum and hypoplastic left heart syndrome in Meckel-Gruber syndrome: a case report.

    Science.gov (United States)

    Taweevisit, Mana; Treetipsatit, Jitsupa; Tantbirojn, Patou; Thorner, Paul Scott

    2009-01-01

    Meckel-Gruber syndrome (MKS) is a fatal, autosomal recessive disorder characterized by malformation of central nervous system, particularly occipital encephalocele, bilateral renal dysplasia, and polydactyly. However, the clinical findings of this syndrome encompass various organ abnormalities as a result of genetic heterogeneity. The associated heart anomaly in MKS is inconstant. Its prevalence is rare and no striking or specific cardiac defects have been documented. We present a case of MKS with combined cor triatriatum sinistrum (left atrium divided into upper and lower compartment by a thin membrane) and hypoplastic left heart syndrome (underdeveloped mitral valve, left ventricle, and aorta) in a 33-week male fetus that was ultrasonographically detected and confirmed by autopsy. In addition to the cardiac defects, the patient was found to have postaxial polydactyly of 4 extremities, Dandy-Walker malformation, bilateral renal cystic dysplasia, and hepatic plate malformation. To the best of our knowledge, this is the first time that a combination of cor triatriatum sinistrum and hypoplastic left heart syndrome in MKS has been reported in the literature.

  10. Biomassa de Rubrivivax gelatinosus na criação de frangos de corte: desempenho animal e cor dos produtos

    Directory of Open Access Journals (Sweden)

    S.V. Avanço

    2014-12-01

    Full Text Available A bactéria Rubrivivax gelatinosus tem sido utilizada experimentalmente no tratamento despoluente de efluentes industriais de abatedouros de aves e peixes, originando uma biomassa contendo pigmentos carotenoides, substâncias que possuem a capacidade de conferir cor aos alimentos e proteger contra reações oxidativas. Este trabalho teve por objetivo verificar o efeito da biomassa de R. gelatinosus adicionada à alimentação de frangos de corte sobre o desempenho animal e a cor de carne e pele. Duzentos pintos machos Cobb 500 foram distribuídos aleatoriamente em 20 boxes para receber, do 36º ao 45º dia de criação, quatro tratamentos com diferentes quantidades de biomassa na ração (T1 [controle] - 0g/kg; T2 - 1g/kg; T3 - 2g/kg; T4 - 3g/kg, em cinco repetições. As pesagens de aves e rações para a análise de desempenho foram feitas no início da criação e ao fim de cada período de crescimento. Ao final do experimento (45 dias, 20 aves de cada tratamento foram abatidas para a determinação da cor objetiva (L - luminosidade, C - saturação, h - tom em pele e carne de peito e coxa. Os resultados obtidos foram submetidos à ANOVA, teste t para a comparação múltipla de médias e análise de regressão com nível de significância de 5%. O ganho de peso e o consumo das aves não diferiram estatisticamente entre si (P>0,05, enquanto o índice de conversão alimentar foi superior para o T1. A luminosidade da carne e da pele aumentou significativamente nos tratamentos que receberam a biomassa. O tom da cor em carne e pele aumentou em direção ao amarelo até a concentração de 2g de biomassa por kg de ração, ao passo que, na concentração de 3g/kg, o aumento foi em direção à tonalidade vermelha. Somente na carne da coxa a saturação da cor sofreu influência da presença da biomassa na dieta. Concluiu-se que, até a proporção de 3g/kg, a biomassa não prejudicou o desempenho e foi eficiente em pigmentar a pele e a carne de

  11. Young infants with atopic dermatitis can display sensitization to Cor a 9, an 11S legumin-like seed-storage protein from hazelnut (Corylus avellana).

    Science.gov (United States)

    Verweij, Marjoke M; Hagendorens, Margo M; De Knop, Kathleen J; Bridts, Chris H; De Clerck, Luc S; Stevens, Wim J; Ebo, Didier G

    2011-03-01

    Allergy to hazelnut (Corylus avellana) can be severe and occur at young age. Atopic dermatitis (AD) can involve sensitization to various foods. The objective is to investigate the pattern of hazelnut sensitization in infants with AD. Sera of 34 infants all under 1 year of age and suffering from AD were selected according to prior specific IgE results. Twenty-nine infants were sensitized to traditional food allergens, five were not. From the 29 infants with a sensitization to at least one food allergen, 20 demonstrated IgE reactivity to hazelnut. All sera were analyzed with the allergen microarray immunoassay (ImmunoCAP ISAC). Twelve (60%) of the children with IgE reactivity to hazelnut demonstrated sensitization to Cor a 9, the 11S legumin-like seed-storage protein from hazelnut. In these infants, no sensitization to Cor a 1, the homologue of the major birch pollen allergen Bet v 1 (Betula verrucosa), or the lipid transfer protein (Cor a 8) from hazelnut was demonstrable. Half of the children sensitized to Cor a 9 demonstrated IgE reactivity to its homologue in peanut (Arachis hypogaea; Ara h 3) from which five were also sensitized to Gly m 6 from soy (Glycine max). None of the infants with AD without IgE reactivity to hazelnut demonstrated sensitization to Cor a 1, 8, or 9. In conclusion, young infants with atopic dermatitis sensitized to hazelnut can already display IgE reactivity to Cor a 9, a potentially dangerous hazelnut component. The mechanism(s) of this early sensitization and its clinical significance remain elusive.

  12. Bronchial asthma with ABPA presenting as PTE

    Directory of Open Access Journals (Sweden)

    Chandrika Azad

    2013-01-01

    Full Text Available Allergic bronchopulmonary aspergillosis (ABPA, as a complication of asthma, is rare in children. The persistent and poorly-controlled asthma leading to cor pulmonale is not uncommon in adults but rarely described in the pediatric age group. Here, we report a case of asthma and ABPA complicated by pulmonary thrombo-embolism and cor pulmonale. To the best of our knowledge, such association has never been reported in the pediatric age group.

  13. Articulações entre gênero e raça/cor em situações de violência de gênero

    OpenAIRE

    Raquel da Silva Silveira; Henrique Caetano Nardi; Giselle Spindler

    2014-01-01

    Este artigo discute teoricamente as articulações entre gênero e raça/cor na temática da violência de gênero nas relações de intimidade. A fundamentação teórica é composta pelos estudos de Michel Foucault sobre as relações de poder, pelos estudos contemporâneos de gênero (Joan Scott, Heleith Saffioti, Karin Smigay) e pelos estudos de raça/cor (Florestan Fernandes, Lilia Schwarcz). O trabalho de campo, envolvendo entrevistas e análise de andamento de processos judiciais, foi desenvolvido no Jui...

  14. Títulos e temas de 1 Cor 6,12-20 na unidade dos capítulos 5-7 = Titles and themes of 1 cor 6.12 -20 in theunity of the chapters 5-7

    Directory of Open Access Journals (Sweden)

    Oliveira, Flávio Martinez de

    2011-01-01

    Full Text Available Apresentam-se os títulos mais encontrados em 1 Cor 6,12-20 e na unidade dos capítulos 5-7. Expõem-se as propostas de articulação da perícope na unidade para propor, a partir de tais títulos e articulação, lendo a perícope, os temas aí considerados centrais. Tais temas são uma proposta de teologia bíblica para a perícope em seu contexto. Esta inspira a existência corporal cristã, tema da tese do autor, onde introduz e motiva a exegese lá exposta. Os temas escolhidos na perícope são porneia e corpo, pecado contra o corpo, corpo de Cristo e templo do Espírito Santo. São alternativas mutuamente excludentes o contato sexual com a prostituta, que implica a inteira existência corporal, e a pertença ao corpo de Cristo, no qual somos inseridos pelo Espírito Santo, do qual somos o templo. Identidade, estilo de vida e comportamento cristãos, teologia e ética são inseparáveis. Estas relações não eram compreendidas por muitos coríntios, os quais Paulo tem em vista. O corpo é central na perícope, perpassa toda a Primeira Carta aos Coríntios e relaciona-se ao próprio Evangelho de Paulo enquanto teologia do corpo. A porneia envolve a pessoa inteira de maneira estável e é um dos problemas que colocam a comunidade em conflito, ao lado de outras controvérsias conhecidas, e com esta relacionadas, como aquelas referentes aos carismas, à idolatria e à própria autoridade de Paulo

  15. Pulse wave velocity and the non-invasive methods used to assess it: Complior, SphygmoCor, Arteriograph and Vicorder.

    Science.gov (United States)

    Davies, Jennifer M; Bailey, Marc A; Griffin, Kathryn J; Scott, D Julian A

    2012-12-01

    Pulse wave velocity (PWV) is a known indicator of arterial stiffness and cardiovascular risk. We critically evaluated the evidence supporting the four main non-invasive devices available to assess it: Complior, SphygmoCor, Arteriograph and Vicorder. PubMed and Medline databases (1960-2011) were searched to identify studies reporting carotid-femoral PWV in humans using one or more of the four devices. Of the 183 articles retrieved, 43 met inclusion criteria. The Arteriograph device demonstrated least variance but had poor agreement with the other devices. Undisputable reference values for PWV need to be established and internationally agreed, and a standardized method for superficial distance measurement generated to reduce variability. Further studies comparing all four devices with invasive assessment are necessary.

  16. Plexos coróides: estudo histopatológico em diferentes faixas etárias

    OpenAIRE

    Deise Regina Maffazzoni; Lígia Maria Barbosa-Coutinho

    1986-01-01

    Os autores estudaram 146 casos de plexos coróides provenientes de autópsias realizadas no Departamento de Patologia da FFFCMPA, no período de janeiro de 1983 a outubro de 1984, com a finalidade de analisar as alterações histo-patológicas nas diferentes fases da vida. As idades dos pacientes estudados oscilaram de 26 semanas de vida intra-uterina a 87 anos. O estudo abrange 6 fetos, 26 recém-nascidos, 34 casos até um ano de idade, 4 de um a dois anos, 14 de 2 a 10 anos, 3 de 10 a 20 anos, 7 en...

  17. CORS Baade-Wesselink method in the Walraven photometric system : the period-radius and the period-luminosity relation of classical Cepheids

    NARCIS (Netherlands)

    Molinaro, R.; Ripepi, V.; Marconi, M.; Bono, G.; Lub, J.; Pedicelli, S.; Pel, J. W.

    2011-01-01

    We present a new derivation of the CORS Baade-Wesselink method in the Walraven photometric system. We solved the complete Baade-Wesselink equation by calibrating the surface brightness function with a recent grid of atmosphere models. The new approach was adopted to estimate the mean radii of a samp

  18. Associação entre cor/raça, obesidade e diabetes em idosos da comunidade: dados do Estudo FIBRA

    Directory of Open Access Journals (Sweden)

    Maria Clara Moretto

    Full Text Available Resumo: O objetivo deste trabalho foi investigar o efeito da cor/raça em medidas indicadoras de adiposidade corporal (índice de massa corporal - IMC, circunferência de cintura - CC e relação cintura-quadril - RCQ, bem como sua relação com o diabetes, em idosos residentes na área urbana de sete localidades brasileiras, conforme o gênero. O estudo transversal foi realizado com uma amostra probabilística composta por 2.566 idosos de 65 anos ou mais, participantes do Estudo FIBRA (Fragilidade em Idosos Brasileiros. Foram utilizadas variáveis sociodemográficas autorrelatadas (gênero, idade, cor/raça, escolaridade e renda familiar, medidas antropométricas indicadoras de obesidade geral (IMC e abdominal (CC e RCQ e diabetes autorreferida. Ajustando-se para escolaridade e renda, a cor/raça branca associou-se a maiores valores de CC (p = 0,001 e RCQ (p > 0,001, no gênero masculino, independentemente do diabetes. Entretanto, ao considerar apenas a amostra de diabéticos, a cor/raça preta passou a associar-se à obesidade geral (IMC (p = 0,007 e central (CC (p > 0,001, apenas entre as mulheres.

  19. Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways.

    Science.gov (United States)

    Feng, Chenchen; Zhang, Jian; Li, Xuecang; Ai, Bo; Han, Junwei; Wang, Qiuyu; Wei, Taiming; Xu, Yong; Li, Meng; Li, Shang; Song, Chao; Li, Chunquan

    2016-09-14

    Metabolic pathway analysis is a popular strategy for comprehensively researching metabolites and genes of interest associated with specific diseases. However, the traditional pathway identification methods do not accurately consider the combined effect of these interesting molecules and neglects expression correlations or topological features embedded in the pathways. In this study, we propose a powerful method, Subpathway-CorSP, for identifying metabolic subpathway regions. This method improved on original pathway identification methods by using a subpathway identification strategy and emphasizing expression correlations between metabolites and genes of interest based on topological features within the metabolic pathways. We analyzed a prostate cancer data set and its metastatic sub-group data set with detailed comparison of Subpathway-CorSP with four traditional pathway identification methods. Subpathway-CorSP was able to identify multiple subpathway regions whose entire corresponding pathways were not detected by traditional pathway identification methods. Further evidences indicated that Subpathway-CorSP provided a robust and efficient way of reliably recalling cancer-related subpathways and locating novel subpathways by the combined effect of metabolites and genes. This was a novel subpathway strategy based on systematically considering expression correlations and topological features between metabolites and genes of interest within given pathways.

  20. KinCor, a national registry for paediatric patients with congenital and other types of heart disease in the Netherlands : aims, design and interim results

    NARCIS (Netherlands)

    Silva, L M; Kuipers, I M; van den Heuvel, F; Mendes, R; Berger, R.M.F.; van Beynum, I M; Rozendaal, L; Rammeloo, L A J; van Iperen, G. G.; Schokking, M; Frerich, S; Blom, N A; Breur, J M P J; Helbing, W A

    OBJECTIVE: Studies in children with heart disease have been hampered by a lack of easily identifiable patient groups. Currently, there are few prospective population-based registries covering the entire spectrum of heart disease in children. KinCor is a Dutch national registry for children with

  1. KinCor, a national registry for paediatric patients with congenital and other types of heart disease in the Netherlands: Aims, design and interim results

    NARCIS (Netherlands)

    L.M. Silva (Lindsay); I.M. Kuipers (Irene); F. van den Heuvel (F.); Mendes, R.; R.M.F. Berger (Rolf); I.M. van Beynum (I.); Rozendaal, L.; L. Rammeloo (Lukas); G.G. van Iperen (Gabrielle); M. Schokking (Michiel); Frerich, S.; N.A. Blom (Nico); J.M.P.J. Breur (Johannes M.P.J.); W.A. Helbing (Willem)

    2016-01-01

    textabstractObjective Studies in children with heart disease have been hampered by a lack of easily identifiable patient groups. Currently, there are few prospective population-based registries covering the entire spectrum of heart disease in children. KinCor is a Dutch national registry for

  2. KinCor, a national registry for paediatric patients with congenital and other types of heart disease in the Netherlands: aims, design and interim results

    NARCIS (Netherlands)

    Silva, L.M.; Kuipers, I.M.; Heuvel, F. van den; Mendes, R.; Berger, R.M.; Beynum, I.M. van; Rozendaal, L.; Rammeloo, L.A.; Iperen, G.G. van; Schokking, M.; Frerich, S.; Blom, N.A.; Breur, J.M.; Helbing, W.A.

    2016-01-01

    OBJECTIVE: Studies in children with heart disease have been hampered by a lack of easily identifiable patient groups. Currently, there are few prospective population-based registries covering the entire spectrum of heart disease in children. KinCor is a Dutch national registry for children with

  3. KinCor, a national registry for paediatric patients with congenital and other types of heart disease in the Netherlands : aims, design and interim results

    NARCIS (Netherlands)

    Silva, L. M.; Kuipers, I. M.; van den Heuvel, F.; Mendes, R.; Berger, R. M. F.; van Beynum, I. M.; Rozendaal, L.; Rammeloo, L. A. J.; van Iperen, G. G.; Schokking, M.; Frerich, S.; Blom, N. A.; Breur, J. M. P. J.; Helbing, W. A.

    2016-01-01

    Objective Studies in children with heart disease have been hampered by a lack of easily identifiable patient groups. Currently, there are few prospective population-based registries covering the entire spectrum of heart disease in children. KinCor is a Dutch national registry for children with heart

  4. InsCor: um método simples e acurado para avaliação do risco em cirurgia cardíaca

    Directory of Open Access Journals (Sweden)

    Omar A. V. Mejía

    2013-03-01

    Full Text Available FUNDAMENTO: Escores de risco apresentam dificuldades para obter o mesmo desempenho em diferentes populações. OBJETIVO: Criar um modelo simples e acurado para avaliação do risco nos pacientes operados de doença coronariana e/ou valvar no Instituto do Coração da Universidade de São Paulo (InCor-HCFMUSP. MÉTODOS: Entre 2007 e 2009, 3.000 pacientes foram operados consecutivamente de doença coronariana e/ou valvar no InCor-HCFMUSP. Desse registro, dados de 2/3 dos pacientes foram utilizados para desenvolvimento do modelo (técnica de bootstrap e de 1/3 para validação interna do modelo. O desempenho do modelo (InsCor foi comparado aos complexos 2000 Bernstein-Parsonnet (2000BP e EuroSCORE (ES. RESULTADOS: Apenas 10 variáveis foram selecionadas: Idade > 70 anos; sexo feminino; cirurgia de revascularização coronariana + valva; infarto de miocárdio < 90 dias; reoperação; tratamento cirúrgico da valva aórtica; tratamento cirúrgico da valva tricúspide; creatinina < 2mg/dL; fração de ejeção < 30%; e eventos. O teste de Hosmer Lemeshow para o InsCor foi de 0,184, indicando uma excelente calibração. A área abaixo da curva ROC foi de 0,79 para o InsCor, 0,81 para o ES e 0,82 para o 2000BP, confirmando que os modelos são bons e similares na discriminação. CONCLUSÕES: O InsCor e o ES tiveram melhor desempenho que o 2000BP em todas as fases da validação; pórem o novo modelo, além de se identificar com os fatores de risco locais, é mais simples e objetivo para a predição de mortalidade nos pacientes operados de doença coronariana e/ou valvar no InCor-HCFMUSP.

  5. Clinical assessment of the efficacy of SpineCor brace in the correction of postural deformities in the course of idiopathic scoliosis.

    Science.gov (United States)

    Plewka, Barbara; Sibiński, Marcin; Synder, Marek; Witoński, Dariusz; Kołodziejczyk-Klimek, Katarzyna; Plewka, Michał

    2013-03-26

    The objective of the study was to perform a clinical, comparative assessment of the degree of postural deformities before and after the treatment of idiopathic scoliosis in patients treated with SpineCor brace compared to the control group. A group of 90 children with idiopathic scoliosis (including 74 girls) at the average age of 12.2 was subject to prospective observation. Average pre-treatment Cobb angle was 24.9° in the thoracic spine and 25.8° in the lumbar spine. The group actively treated with the SpineCor brace consisted of 45 children, while the control group consisted of the remaining 45 children with the natural course of the disease. Both groups did not differ significantly in terms of age, gender, height, body weight, Risser sign of skeletal maturity and baseline clinical and radiological parameters of scoliosis. Significant reduction of rib hump was observed upon 2-year SpineCor brace treatment (P=0.04) compared to the group treated by physiotherapy only (P=0.91). Similarly, improvement in lumbar prominence was observed in the actively treated group (P=0.009), with a trend towards worse results in the control group (P=0.07) In the group treated with the SpineCor brace, significant reduction in pectoral and hamstring muscle contractures as well as reduction in shoulder asymmetry and reduction in anterior and posterior vertical deviation were observed. Treatment using the SpineCor dynamic brace leads to a clinical improvement in posture, particularly to reduction in rib hump, lumbar prominence and muscular contractures.

  6. Comparison of color indexes for tomato ripening Comparação dos índices de cor para maturação do tomate

    Directory of Open Access Journals (Sweden)

    Andrés F. López Camelo

    2004-09-01

    Full Text Available Color in tomato is the most important external characteristic to assess ripeness and postharvest life, and is a major factor in the consumer's purchase decision. Degree of ripening is usually estimated by color charts. Colorimeters, on the other hand, express colors in numerical terms along the L*, a* and b* axes (from white to black, green to red and blue to yellow, respectively within the CIELAB color sphere which are usually mathematically combined to calculate the color indexes. Color indexes and their relationship to the visual color classification of tomato fruits vine ripened were compared. L*, a* and b* data (175 observations from eleven cultivars from visually classified fruits at harvest in six ripening stages according to the USDA were used to calculate hue, chroma, color index, color difference with pure red, a*/b* and (a*/b*². ANOVA analysis were performed and means compared by Duncan's MRT. Color changes throughout tomato ripening were the result of significant changes in the values of L*, a* and b*. Under the conditions of this study, hue, color index, color difference and a*/b* expressed essentially the same, and the color categories were significantly different in terms of human perception, with hue showing higher range of values. Chroma was not a good parameter to express tomato ripeness, but could be used as a good indicator of consumer acceptance when tomatoes are fully ripened. The (a*/b*² relationship had the same limitations as chroma. For vine ripened fruits, hue, color index, color difference and a*/b* could be used as objective ripening indexes. It would be interesting to find out what the best index would be if ripening took place under inadequate conditions of temperature and ilumination.A cor do tomate é a característica externa mais importante que permite determinar a maturação e estimar a vida pós-colheita, sendo por sua vez um fator importante na decisão de compra por parte do consumidor. O grau de matura

  7. Biosíntese de androgénios no Plexo Coróide : o papel da 5[alfa]-reductase

    OpenAIRE

    Rodrigues, Ângela Patrícia Rosa

    2009-01-01

    A enzima 5α‐reductase (5α‐R) metaboliza a testosterona (T) a um androgénio activo, a 5α‐dihidrotestosterona (DHT), em tecidos periféricos incluindo diversas regiões do cérebro. Recentemente o nosso grupo de investigação demonstrou a presença do mRNA da 5α‐reductase no plexo coróide (CP) de rato. O plexo coróide é responsável pela produção do fluido cerebroespinhal e também apresenta capacidades neuroprotectoras. Durante o processo de envelhecimento, o CP apresenta um declíni...

  8. Chorea: clinical correlates of 119 cases Coréia: análise clínica de 119 casos

    Directory of Open Access Journals (Sweden)

    Maria Fernanda Mendes

    1996-09-01

    Full Text Available Chorea is a clinical syndrome characterized by abnormal involuntary arrhythmic movements, randomly distributed in time, affecting mainly the distal parts of the limbs. There are many diseases associated with chorea but the distribution of the etiologies vary too much in different parts of the world. We intended to study the etiologies of chorea in a Movement Disorders Unit of a university hospital-based outpatient clinic in Brazil. We studied the records of 119 patients with chorea based in the diagnostic criteria of the World Federation of Neurology. Sydenham's chorea (SC was the most frequent cause of chorea (51.3% of our sample. Other common causes were Huntington's chorea (18.5% and chorea post-stroke (9.2%. SC is not commonly seen in developed countries nowadays but is not rare in Brazil. SC patients generally have the clinical manifestation of it in the first 20 years of age and girls are more affected than boys and this feature was observed in our sample. Based on our own experience and in the review of the literature we propose an etiological classification of chorea.Coréia é uma síndrome caracterizada por movimentos involuntários arrítmicos, rápidos, abruptos, não repetitivos no tempo e com distribuição variável, preferentemente distal. O número de entidades clínicas reconhecidamente associadas a movimentos coréicos tem se tornado cada vez maior com o passar do tempo. Propusemo-nos estudar a frequência e algumas características epidemiológicas das coréias atendidas em um ambulatório especializado em distúrbios do movimento. Foram estudados os prontuários de 119 pacientes com o diagnóstico sindrômico de coréia. O predomínio absoluto foi de coréia de Sydenham (CS com 51,3% do total da amostra. Outras causas frequentes foram doença de Huntington (DH presente em 18,5% e a coréia secundária a doença cerebrovascular em 9,2% dos pacientes. O sexo feminino predominou em todas as faixas etárias, mas principalmente

  9. Alteração da cor da madeira de teca por tratamento térmico

    Directory of Open Access Journals (Sweden)

    Juliana de Oliveira Lopes

    Full Text Available O objetivo deste estudo foi determinar o efeito do tratamento térmico na alteração da cor da madeira de teca (Tectona grandis L. f., proveniente de plantios de diferentes espaçamentos. Amostras de madeira de cerne e de alburno foram tratadas a 180 e 200ºC durante 2h30min. As análises colorimétricas foram realizadas com o auxílio do espectrofotômetro CM 2600d no sistema CIE L*a*b*. Após o tratamento, a madeira teve perda de luminosidade, tornado-se mais escura, o que se mostrou mais acentuado para o tratamento a 200ºC. As madeiras de cerne e alburno apresentaram comportamentos diferentes para as coordenadas a* e b*, dependendo do espaçamento, antes e após o tratamento. Ocorreu uma maior formação de pigmento vermelho e perda de pigmento amarelo nas madeiras de cerne e alburno tratadas a 200ºC.

  10. 'PiraRoxa': cultivar de alface crespa de cor vermelha intensa 'PiraRoxa': triple red lettuce cultivar

    Directory of Open Access Journals (Sweden)

    Fernando César Sala

    2005-03-01

    Full Text Available 'PiraRoxa' é uma cultivar de alface (Lactuca sativa L. crespa de cor vermelha intensa, resistente à Bremia lactucae, Thielaviopsis basicola e LMV, patótipo II. Foi selecionada por meio do método genealógico a partir do cruzamento entre o tipo Lolla Rossa 'RS 521998' e a cv. Gizela. Apresenta plantas grandes e vigorosas, folhas crespas, coloração vermelha intensa e brilhante. Em ensaios conduzidos no verão (2003/2004 o pendoamento da 'PiraRoxa' foi de 10 e 20 dias mais lento quando comparado às cvs. Banchu New Red Fire e Loretta, respectivamente. Trata-se da primeira cultivar tropicalizada para o segmento de alface vermelha com resistência a doenças no Brasil.'PiraRoxa' is a triple red leaf lettuce (Lactuca sativa L. cultivar resistant to Bremia lactucae, Thielaviopsis basicola and LMV, pathotype II. This cv. was obtained through pedigree selection from the cross between a Lolla Rossa 'RS 521998' and cv. Gizela. This shiny and intense red lettuce presents vigorous plants with loose leaves. In summer trials (2003/2004 'PiraRoxa' presented slow bolting performance (10 to 20 days later in comparison to cvs. Banchu New Red Fire and Loretta. This is the first tropicalized red leaf lettuce with multiple disease resistance developed in Brazil.

  11. The 3-D strain patterns in Turkey using geodetic velocity fields from the RTK-CORS (TR) network

    Science.gov (United States)

    Kutoglu, Hakan Senol; Toker, Mustafa; Mekik, Cetin

    2016-03-01

    This study presents our use of GPS data to obtain and quantify the full continuous strain tensor using a 3-D velocity field in Turkey. In this study, GPS velocities improve the estimation of short-term strain tensor fields for determining the seismic hazard of Turkey. The tensorial analysis presents different aspects of deformation, such as the normal and shear strains, including their directions, the compressional and extensional strains. This analysis is appropriate for the characterizing the state of the current seismic deformation. GPS velocity data from continuous measurements (2009-2012) to estimate deformations were processed using the GAMIT/GLOBK software. Using high-rate GPS data from permanent 146 GNSS stations (RTK-CORS-TR network), the strain distribution was determined and interpolated using a biharmonic spline technique. We show the strain field patterns within axial and plane form at several critical locations, and discuss these results within the context of the seismic and tectonic deformation of Turkey. We conclude that the knowledge of the crustal strain patterns provides important information on the location of the main faults and strain accumulation for the hazard assessment. The results show an agreement between the seismic and tectonic strains confirming that there are active crustal deformations in Turkey.

  12. GLOBAL CORONAL SEISMOLOGY IN THE EXTENDED SOLAR CORONA THROUGH FAST MAGNETOSONIC WAVES OBSERVED BY STEREO SECCHI COR1

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Ryun-Young; Kramar, Maxim; Wang, Tongjiang; Ofman, Leon [Department of Physics, Institute for Astrophysics and Computational Sciences, Catholic University of America, 620 Michigan Avenue, Washington, DC 20064 (United States); Davila, Joseph M. [NASA Goddard Space Flight Center, Solar Physics Laboratory, Code 671, Greenbelt, MD 20771 (United States); Chae, Jongchul [Astronomy Program, Department of Physics and Astronomy, Seoul National University (Korea, Republic of); Zhang, Jie [School of Physics, Astronomy and Computational Sciences, George Mason University, 4400 University Drive, MSN 6A2, Fairfax, VA 22030 (United States)

    2013-10-10

    We present global coronal seismology for the first time, which allows us to determine inhomogeneous magnetic field strength in the extended corona. From the measurements of the propagation speed of a fast magnetosonic wave associated with a coronal mass ejection (CME) and the coronal background density distribution derived from the polarized radiances observed by the STEREO SECCHI COR1, we determined the magnetic field strengths along the trajectories of the wave at different heliocentric distances. We found that the results have an uncertainty less than 40%, and are consistent with values determined with a potential field model and reported in previous works. The characteristics of the coronal medium we found are that (1) the density, magnetic field strength, and plasma β are lower in the coronal hole region than in streamers; (2) the magnetic field strength decreases slowly with height but the electron density decreases rapidly so that the local fast magnetosonic speed increases while plasma β falls off with height; and (3) the variations of the local fast magnetosonic speed and plasma β are dominated by variations in the electron density rather than the magnetic field strength. These results imply that Moreton and EIT waves are downward-reflected fast magnetosonic waves from the upper solar corona, rather than freely propagating fast magnetosonic waves in a certain atmospheric layer. In addition, the azimuthal components of CMEs and the driven waves may play an important role in various manifestations of shocks, such as type II radio bursts and solar energetic particle events.

  13. Age-dependent sensitization to the 7S-vicilin-like protein Cor a 11 from hazelnut (Corylus avellana) in a birch-endemic region

    OpenAIRE

    Verweij, MM; Hagendorens, MM; Trashin, Stanislav; Cucu, Tatiana; De Meulenaer, Bruno; Devreese, Bart; Bridts, CH; De Clerck, LS; Ebo, DG

    2012-01-01

    Background: Hazelnut (Corylus avellana) allergy exhibits age and geographically distinct sensitization patterns that have not yet been fully resolved. Objective: To study sensitization to Cor a 11 in different age groups of hazelnut-allergic patients and infants with atopic dermatitis (AD) sensitized to hazelnut in a birch-endemic region. Methods: Sera from 80 hazelnut-allergic patients, 33 infants under 1 year of age with AD (24 sensitized and 9 not sensitized to hazelnut), 32 healthy ...

  14. Análise populacional de corós-praga e de outras espécies no planalto do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Mariana Alejandra Cherman

    2014-12-01

    Full Text Available O objetivo deste trabalho foi determinar a relação entre a densidade populacional de espécies de corós (Coleoptera: Melolonthidae reconhecidas como pragas e as outras espécies da mesma família que ocorrem em áreas cultivadas e não cultivadas no planalto, ao norte do Rio Grande do Sul. Foram realizadas amostragens em 23 municípios no período de julho a setembro, nos anos 2009 e 2010, em uma área cultivada e outra sem cultivo. Em cada área, foram abertas trincheiras de 50x25x30cm de profundidade. As larvas coletadas foram identificadas e reunidas em dois grupos: corós-praga e corós de outras espécies. Comparou-se a densidade populacional (no de larvas m-2 entre os dois grupos nas áreas cultivadas e não cultivadas. A densidade de outras espécies foi superior à densidade de espécies-praga, tanto nas áreas cultivadas (9,0 e 3,9 larvas m-2, respectivamente quanto nas áreas não cultivadas (6,6 e 3,9 larvas m-2, respectivamente. Não há diferença na densidade populacional média de corós-praga entre áreas cultivadas e não cultivadas

  15. A utilização da variável raça/cor em Saúde Pública: possibilidades e limites

    Directory of Open Access Journals (Sweden)

    Edna Maria de Araújo

    2009-12-01

    Full Text Available Propôs-se discutir o uso da variável raça/cor como fator determinante de desigualdades sociais e de exposição social ao risco de adoecimento e morte. Trata-se de uma reflexão sobre a produção atual da literatura nacional e internacional da área de Saúde Pública/Epidemiologia. Foram incluídos no estudo 47 artigos originais e de revisão no período de 1990 a 2005. Observou-se que os estudos internacionais procuram debater e fundamentar o uso da variável raça/cor no campo da saúde. No Brasil, a utilização dessa variável em estudos de desigualdade em saúde é ainda incipiente, mas, entre as poucas investigações realizadas, têm sido evidenciados diferenciais que instigam maior produção de pesquisas nessa direção. Investigações sobre o papel da raça/cor na produção de diferenciais em saúde poderão produzir informações capazes de contribuir para a elaboração de políticas destinadas a reduzir desigualdades em saúde.

  16. A utilização da variável raça/cor em Saúde Pública: possibilidades e limites

    Directory of Open Access Journals (Sweden)

    Edna Maria de Araújo

    Full Text Available Propôs-se discutir o uso da variável raça/cor como fator determinante de desigualdades sociais e de exposição social ao risco de adoecimento e morte. Trata-se de uma reflexão sobre a produção atual da literatura nacional e internacional da área de Saúde Pública/Epidemiologia. Foram incluídos no estudo 47 artigos originais e de revisão no período de 1990 a 2005. Observou-se que os estudos internacionais procuram debater e fundamentar o uso da variável raça/cor no campo da saúde. No Brasil, a utilização dessa variável em estudos de desigualdade em saúde é ainda incipiente, mas, entre as poucas investigações realizadas, têm sido evidenciados diferenciais que instigam maior produção de pesquisas nessa direção. Investigações sobre o papel da raça/cor na produção de diferenciais em saúde poderão produzir informações capazes de contribuir para a elaboração de políticas destinadas a reduzir desigualdades em saúde.

  17. Articulações entre gênero e raça/cor em situações de violência de gênero

    Directory of Open Access Journals (Sweden)

    Raquel da Silva Silveira

    2014-08-01

    Full Text Available Este artigo discute teoricamente as articulações entre gênero e raça/cor na temática da violência de gênero nas relações de intimidade. A fundamentação teórica é composta pelos estudos de Michel Foucault sobre as relações de poder, pelos estudos contemporâneos de gênero (Joan Scott, Heleith Saffioti, Karin Smigay e pelos estudos de raça/cor (Florestan Fernandes, Lilia Schwarcz. O trabalho de campo, envolvendo entrevistas e análise de andamento de processos judiciais, foi desenvolvido no Juizado de Violência Doméstica e Familiar contra a Mulher e na Delegacia da Mulher, em Porto Alegre, no período de maio de 2010 a outubro de 2011. Destaca-se como necessária a problematização sobre as formas como as questões de raça/cor se entrecruzam nos discursos sobre violência de gênero nas relações de intimidade, uma vez que a maneira como as vulnerabilidades são vividas pelas mulheres variam fortemente de acordo com suas experiências singulares de vida e com os marcadores sociais.

  18. A cor da dor: iniquidades raciais na atenção pré-natal e ao parto no Brasil

    Directory of Open Access Journals (Sweden)

    Maria do Carmo Leal

    Full Text Available Poucas pesquisas com foco nas influências da raça/cor no tocante à experiência de gestação e parto foram conduzidas no Brasil, sendo inédita a análise de abrangência nacional. Este estudo teve como objetivo avaliar as iniquidades na atenção pré-natal e parto de acordo com a raça/cor utilizando o método de pareamento baseado nos escores de propensão. Os dados são oriundos da pesquisa Nascer no Brasil: Pesquisa Nacional sobre Parto e Nascimento, um estudo de base populacional de abrangência nacional com entrevista e avaliação de prontuários de 23.894 mulheres em 2011/2012. Regressões logísticas simples foram utilizadas para estimar as razões de chance (OR e respectivos intervalos de 95% de confiança (IC95% da raça/cor associada aos desfechos analisados. Em comparação às brancas, puérperas de cor preta possuíram maior risco de terem um pré-natal inadequado (OR = 1,6; IC95%: 1,4-1,9, falta de vinculação à maternidade (OR = 1,2; IC95%: 1,1-1,4, ausência de acompanhante (OR = 1,7; IC95%: 1,4-2,0, peregrinação para o parto (OR = 1,3; IC95%: 1,2-1,5 e menos anestesia local para episiotomia (OR = 1,5 (IC95%: 1,1-2,1. Puérperas de cor parda também tiveram maior risco de terem um pré-natal inadequado (OR = 1,2; IC95%: 1,1-1,4 e ausência de acompanhante (OR = 1,4; IC95%: 1,3-1,6 quando comparadas às brancas. Foram identificadas disparidades raciais no processo de atenção à gestação e ao parto evidenciando um gradiente de pior para melhor cuidado entre mulheres pretas, pardas e brancas.

  19. Uso da cor da casca como indicador de qualidade do maracujá amarelo (Passiflora edulis Sims. f. flavicarpa Deg. destinado à industrialização

    Directory of Open Access Journals (Sweden)

    DE MARCHI Renata

    2000-01-01

    Full Text Available As características físico-químicas do maracujá amarelo em três estádios de cor de casca (1/3 amarelo, 2/3 amarelo e inteiro amarelo, em quatro épocas da safra/99 foram avaliadas, visando estabelecer o ponto de colheita de melhor qualidade da fruta para a industrialização. Foram determinados o tamanho dos frutos, a cor da casca e da polpa, o rendimento de extração da polpa, o teor de sólidos solúveis totais, o pH, a acidez total, o ratio e o teor de vitamina C. Foi empregado o delineamento experimental inteiramente casualizado, com 8 repetições, 5 frutos por parcela e 3 tratamentos. Os resultados mostraram que o rendimento de polpa não apresentou diferença significativa entre os tratamentos e entre as colheitas. Com relação à cor da polpa, houve diferença significativa entre os três estádios apenas na 1ª colheita. Os frutos de casca 1/3 amarela apresentaram teor de sólidos solúveis significativamente inferior aos demais apenas na 3ª e 4ª colheitas, mas o maior valor médio ocorreu na 4ª colheita. O teor de acidez total dos frutos de casca inteira amarela foi significativamente inferior àqueles das colheitas 2, 3 e 4. Os valores mais elevados de vitamina C foram obtidos na 1ª colheita e, os frutos de casca 1/3 amarela apresentaram teores significativamente inferiores nas colheitas 1 e 2. De maneira geral, os resultados indicaram que, embora tenham ocorrido algumas diferenças nas características físico-químicas dos frutos nos diferentes estádios de cor de casca, frutos colhidos em todos os estádios de cor de casca estudados apresentaram-se adequados à industrialização.

  20. Magnesium Uptake by CorA Transporters Is Essential for Growth, Development and Infection in the Rice Blast Fungus Magnaporthe oryzae.

    Science.gov (United States)

    Reza, Md Hashim; Shah, Hiral; Manjrekar, Johannes; Chattoo, Bharat B

    2016-01-01

    Magnaporthe oryzae, the causative organism of rice blast, infects cereal crops and grasses at various stages of plant development. A comprehensive understanding of its metabolism and the implications on pathogenesis is necessary for countering this devastating crop disease. We present the role of the CorA magnesium transporters, MoAlr2 and MoMnr2, in development and pathogenicity of M. oryzae. The MoALR2 and MoMNR2 genes individually complement the Mg2+ uptake defects of a S. cerevisiae CorA transporter double mutant. MoALR2 and MoMNR2 respond to extracellular Mg2+ and Ca2+ levels and their expression is elevated under Mg2+ scarce conditions. RNA silencing mediated knockdown of MoALR2 (WT+siALR2, Δmnr2+siALR2 and ALR2+MNR2 simultaneous silencing) drastically alters intracellular cation concentrations and sensitivity to metal ions. MoALR2 silencing is detrimental to vegetative growth and surface hydrophobicity of mycelia, and the transformants display loss of cell wall integrity. MoALR2 is required for conidiogenesis and appressorium development, and is essential for infection. Investigation of knockdown transformants reveal low cAMP levels and altered expression of genes encoding proteins involved in MoMps1 cell wall integrity and cAMP MoPmk1 driven MAP Kinase signaling pathways. In contrast to MoALR2 knockdowns, the MoMNR2 deletion (Δmnr2) shows increased sensitivity to CorA inhibitors as well as altered cation sensitivity, but has limited effect on surface hydrophobicity and severity of plant infection. Interestingly, MoALR2 expression is elevated in Δmnr2. Impairment of development and infectivity of knockdown transformants and altered intracellular cation composition suggest that CorA transporters are essential for Mg2+ homeostasis within the cell, and are crucial to maintaining normal gene expression associated with cell structure, signal transduction and surface hydrophobicity in M. oryzae. We suggest that CorA transporters, and especially MoALR2

  1. SELEÇÃO ELETRÔNICA PELA COR NA DESCONTAMINAÇÃO DE AMENDOIM CONTAMINADO COM AFLATOXINAS

    Directory of Open Access Journals (Sweden)

    Zovico Cristiane

    1999-01-01

    Full Text Available Quarenta e dois lotes comerciais de 300 kg de amendoim descascado, produzidos em 1997 e contaminados com aflatoxinas, foram submetidos à seleção eletrônica pela cor para verificar a eficiência desse processo na melhoria da qualidade de lotes de amendoim quanto à diminuição da contaminação com aflatoxinas. Os lotes de amendoim foram classificados pelo tamanho como normalmente utilizados pela cerealista, sendo 22 lotes de amendoim graúdo (7,5 a 7,9mm e 20 lotes de amendoim miúdo (6,4 a 7,1mm, nos quais os níveis de contaminação inicial variaram de 7 a 3.763 mg/kg e de 76 a 3.309 mg/kg, respectivamente. Nos 42 lotes, não foram detectadas aflatoxinas em dois lotes de amendoim graúdo e 1 de amendoim miúdo. Este trabalho demonstrou que o processo de seleção eletrônica retirou grãos altamente contaminados, concentrando-os na porção rejeito. Apesar disso, não houve uma melhora substancial nos níveis iniciais médios de contaminação dos lotes indicando que a distribuição das aflatoxinas estava generalizada, uma vez que, os grãos selecionados também estavam contaminados. Em lotes com menor contaminação pode funcionar. Novos estudos serão realizados.

  2. Mapeamento do fósforo adsorvido por meio da cor e da suscetibilidade magnética do solo

    Directory of Open Access Journals (Sweden)

    Rafael Gonçalves Peluco

    2015-03-01

    Full Text Available O objetivo deste trabalho foi avaliar a possibilidade de se mapear o fósforo adsorvido por meio da avaliação da cor e da suscetibilidade magnética do solo. O experimento foi realizado em área de cana-de-açúcar com 380 ha, que compreendia quatro tipos de Latossolos, com diferentes texturas e fertilidades naturais. Foram coletadas 241 amostras de solo, na profundidade de 0,00-0,25 m. O índice de avermelhamento do solo foi calculado a partir dos valores de matiz, valor e croma das amostras, obtidos com espectroscopia de reflectância difusa. Foram ajustados modelos de regressão entre o fósforo adsorvido e a suscetibilidade magnética ou o índice de avermelhamento dos solos. A dependência espacial dos dados foi avaliada por meio de geoestatística. A suscetibilidade magnética correlaciona-se significativamente ao fósforo adsorvido, o que possibilita seu uso como componente de funções de pedotransferência para quantificação indireta do fósforo adsorvido ao solo. O índice de avermelhamento e a suscetibilidade magnética apresentam dependência espacial com o fósforo adsorvido. A suscetibilidade magnética e o índice de avermelhamento dos solos, avaliado pela espectroscopia de reflectância difusa, podem auxiliar no mapeamento e na identificação de áreas com diferentes potenciais de adsorção de fósforo.

  3. Expression and functional analysis of the CorA-MRS2-ALR-type magnesium transporter family in rice.

    Science.gov (United States)

    Saito, Takayuki; Kobayashi, Natsuko I; Tanoi, Keitaro; Iwata, Naoko; Suzuki, Hisashi; Iwata, Ren; Nakanishi, Tomoko M

    2013-10-01

    Maintenance of an appropriate magnesium ion (Mg(2+)) concentration is essential for plant growth. In Arabidopsis thaliana, the CorA-MRS2-ALR-type proteins, named MRS2/MGT family proteins, are reportedly localized in various membranes and they function in Mg transport. However, knowledge of this family in other plant species is extremely limited. Furthermore, differential diversification among dicot and monocot plants suggested by phylogenetic analysis indicates that the role of the Arabidopsis MRS2/MGT family proteins is not the same in monocot plants. For a further understanding of this family in higher plants, functional analysis and gene expression profiling of rice MRS2/MGT family members were performed. A phylogenetic tree based on the isolated mRNA sequences of nine members of the OsMRS2 family confirmed that the MRS2/MGT family consists of five clades (A-E). A complementation assay in the yeast CM66 strain showed that four of the nine members possessed the Mg(2+) transport ability. Transient green fluorescent protein (GFP) expression in the isolated rice protoplast indicated that OsMRS2-5 and OsMRS2-6, belonging to clades D and A, respectively, localized in the chloroplast. Expression levels of these genes were low in the unexpanded yellow-green leaf, but increased considerably with leaf maturation. In addition, diurnal oscillation of expression was observed, particularly in OsMRS2-6 expression in the expanded leaf blade. We conclude that OsMRS2 family members function as Mg transporters and suggest that the genes belonging to clade A encode the chloroplast-localized Mg(2+) transporter in plants.

  4. Experimental and numerical optimization of a coronagraph external occulter. Application to SECCHI-COR2 and GOES-R SCOR

    Science.gov (United States)

    Thernisien, A.; Colaninno, R. C.; Plunkett, S.; Socker, D. G.; Gong, Q.; Landini, F.

    2005-08-01

    The space-born coronagraph is an instrument used to observe the solar corona, the outer atmosphere of the Sun, typically over a range of altitudes from close to the limb of the solar disk to tens of solar radii. The brightness of the solar disk is many orders of magnitude greater than that of the corona. A coronagraph is designed to reject the light from the solar disk such that the corona is observable. An externally-occulted coronagraph is basically a telescope that forms an image of the corona, with the addition of an external occulter before and an internal occulter after the objective elements and stops, positioned and sized to reject light from the solar disk. The main source of stray light is diffraction of solar light around the edge of the external occulter, which is then scattered into the image plane by the optical elements. The occulters and stops are designed to reduce the intensity of diffracted and scattered light in the coronagraph as much as possible. We have developed a numerical model of the diffraction by an external occulter system and validated the model experimentally. We used the model to optimize the external occulter design for the SECCHI COR2 instrument, which is part of the NASA STEREO mission. We also used the model for the GOES-R SCOR concept design to predict the sensitivity of the instrument to misalignment and off-pointing from the Sun. In this paper, we will present the results of this experimental and numerical study of the performance of the external occulters on these instruments.

  5. Melanoma de corpo ciliar e coróide: relato de caso Choroidal and ciliary body melanoma: case report

    Directory of Open Access Journals (Sweden)

    Aline Amaral Fulgêncio da Cunha

    2010-04-01

    Full Text Available Melanomas oculares correspondem a 5% de todos os melanomas e 85% deles têm origem no trato uveal. Melanoma uveal é o tumor maligno intraocular primário mais comum no adulto. Relatamos neste artigo um caso de melanoma uveal em paciente, sexo feminino, 31 anos, com quadro de fotopsia, hiperemia e baixa da acuidade visual no olho esquerdo com evolução de quatro meses. Apresentava ao exame oftalmológico acuidade visual menor que 20/400, grande massa tumoral na região nasal retroiriana, com deslocamento anterior do cristalino, estreitamento da câmara anterior e descolamento seroso da retina. A ecografia sugeriu tratar-se de grande massa tumoral suspeita de melanoma de coróide com invasão do corpo ciliar. A confirmação diagnóstica foi possível por meio do exame anatomopatológico.Ocular melanomas correspond to 5% of all melanomas and 85% of them have its origin in the uveal tract. Uveal melanoma is the most commom primary intraocular malignant tumor in the adult. In this article, a case of uveal melanoma in a 31 year-old female patient, with photopsia, hyperemia and low visual acuity in the left eye with evolution of 4 months is presented. In the ophthalmologic examination, visual acuity was lower than 20/400, a large tumoral mass was noted at the nasal region behind the iris with anterior lens displacement, anterior chamber narrowing and serous retinal detachment. The ocular echography suggested a large tumoral mass as a choroidal melanoma extending to the ciliary body. The confirmation diagnosis was possible through the histopathologic examination.

  6. Preparation and identification of monoclonal antibodies against Cor h 1 allergen%平榛主要过敏原C0rh1单克隆抗体的制备与鉴定

    Institute of Scientific and Technical Information of China (English)

    赵郭存; 张强; 邹菊; 黄钟; 刘志刚

    2011-01-01

    目的 制备和鉴定鼠抗平榛主要变应原Cor h 1的单克隆抗体(Monoclonal Antibody,McAb).方法 用重组Cor h 1蛋白为免疫原,免疫Balb/c小鼠,取免疫小鼠脾细胞与小鼠骨髓瘤NS-1细胞融合.通过间接ELISA法筛选分泌特异性McAb的杂交瘤细胞.用杂交瘤细胞株诱导小鼠产生腹水,再用蛋白A亲和层析法纯化抗体.采用Ig类与亚类鉴定试剂盒鉴定该单克隆抗体的Ig亚型;通过间接ELISA、Western Blotting鉴定该McAbs的特性和交叉性.结果 获得4株可稳定分泌鼠抗平榛主要变应原Cor h l的McAbs,其Ig亚型均为IgGl,均具有良好的效价;ELISA和Western Blotting分析表明该4株单抗均能识别重组Cor h l蛋白,其中3株单抗能够识别天然平榛提取物.结论 成功制备了4株鼠抗平榛主要变应原Cor h 1的单克隆抗体,为建立平榛主要变应原Cor h 1检测及纯化方法 奠定了基础.%This stuffy ained to prepare monoclonal antibodies against Cor h 1 allergen from Dermatophagoides farinae and to characterize their properties. Balb/c mice were immunized with purified recombinant Cor h 1 allergen protein, and the splenocytes of the immunized mice were fused with NS-1 myeloma cells by hybridoma technique. The McAbs against Cor h 1 allergen were purified using affinity chromatography on immobilized Protein A, and identified by ELISA and Western blotting for the specificity, subtype, titers and cross-reactivity. Four hybridoma cell lines secreting McAbs against Cor h 1 allergen were obtained, which were determined as IgG1 subtype and possessed good ascites titers. The four McAbs against Cor h 1 allergen all recognized recombinant Cor h 1 allergen, and the three of them also recognized native extract from Corylus heterophylla. In our study, four monoclonal antibodies against Cor h 1 allergen have prepared successfully, which will facilitate the establishment of detection method for Cor h 1 allergen.

  7. Tomografia de coerência óptica em osteoma de coróide: relato de caso Optical coherence tomography in choroidal osteoma: case report

    Directory of Open Access Journals (Sweden)

    Mário Junqueira Nóbrega

    2005-10-01

    Full Text Available Os autores apresentam um caso de osteoma de coróide diagnosticado em paciente do sexo masculino aos 62 anos de idade. A lesão bem delimitada e pouco elevada no pólo posterior do olho direito acompanhada de vascularização interna e neovascularização de coróide em sua borda temporal superior e inferior levaram à suspeita do tumor. O diagnóstico de certeza foi obtido com ecografia A e B e tomografia computadorizada. A tomografia de coerência óptica mostrou alta refletividade em toda a espessura do osteoma bem como elevação do complexo EPR-cório-capilar na região da membrana neovascular subretiniana. Embora os achados tomográficos descritos na literatura e os observados neste caso sejam variados, a tomografia de coerência óptica pode colaborar no diagnóstico de osteoma de coróide.The authors present a case of choroidal osteoma diagnosed in a 62-year-old male patient. A well-defined and slightly elevated lesion located in the posterior pole of the right eye associated with internal vasculature and choroidal neovascularization at its superior and inferior temporal edge were suspicious of the tumor. Confirmation of diagnosis was obtained with A and B ecography and computed tomography. Optical coherence tomography showed high reflectivity through its thickness as well as elevation of the RPE-choriocapillaris complex at the choroidal neovascularization site. Although the literature and the present case show several different tomographical findings, optical coherence tomography can help establishing the diagnosis of choroidal osteoma.

  8. 宣肺平喘、温阳利水法对肺心病急性加重期合并周围性水肿ADH的影响%The Effectiveness of the Therapy Dispersing Lung-Qi to Relive Asthma, Warming Yang to Promote Diuresis on the Level of ADH of Patients with Cor Pulmonale in Acute Aggravate Stage, Combined with Peripheral Hydrops

    Institute of Scientific and Technical Information of China (English)

    卢云; 张晓云; 黄宁; 陈绍宏

    2007-01-01

    目的 通过多中心、随机、对照、平行、单盲临床研究,对宣肺平喘、温阳利水法治疗肺心病急性加重期合并周围性水肿疗效进行评价,并观察其对抗利尿激素(ADH)的影响.方法 以肺心病急性发作期合并周围性水肿的患者为对象,随机分为两组.治疗组采用中西医结合方案治疗,对照组予以西医常规加安慰剂治疗,两组均治疗14d.比较两组疗效性指标与ADH值情况.结果 治疗组在总体疗效、改善症状体征、纠正电解质紊乱、纠正酸碱失衡等方面优于对照组.两组治疗后均无明显副作用.同时治疗组在降低血清ADH水平方面优于对照组.结论 针对肺心病急性发作期合并周围性水肿的中西医结合治疗可能具有提高总体疗效、改善症状体征、纠正电解质紊乱、纠正酸碱失衡优势,同时对ADH的分泌有一定的抑制作用,提示抑制ADH分泌可能是宣肺平喘、温阳利水法治疗肺心病急性加重期合并周围性水肿的部分机理.

  9. Uso de la corteza del coróngoro Ziziphus amole (Sessé & Moc.) M.C. Johnst. en la medicina tradicional xochipalense

    OpenAIRE

    Pilar América Romero-Castillo; Armando Gómez-Campos; Ma. Cristina Pérez Amador-Barrón; Verónica Muñoz-Ocotero; Alberto Reyes-Dorantes

    2011-01-01

    El objetivo del presente trabajo es valorar el conocimiento y uso medicinal del coróngoro Ziziphus amole (Sessé Moc.) M.C. Johnst. reportado por los habitantes de Xochipala, Guerrero mediante un cuestionario y analizando sus respuestas a través de un análisis estadístico. Se recolectaron frutos, hojas, tallos y corteza, se elaboraron ejemplares botánicos para su confirmación taxonómica. Se realizó un muestreo aleatorio estratificado y se aplicó un cuestionario con preguntas generales a 107 ...

  10. La Praefatio de la traducción latina del Corán de Germán de Silesia

    OpenAIRE

    García Masegosa, Antonio

    2005-01-01

    Como anticipo de la edición crítica de la traducción al latín del Corán, realizada por Domingo Germán de Silesia, se presentan algunos datos importantes sobre el autor y la obra, con un comentario a la misma, que contiene interesantes datos sobre los motivos que indujeron a su composición, así como su intención y estilo. Termina el trabajo con la edición de la mencionada Praefatio. As an advance to his forthcoming critical edition of the Latin translation of the Koran by Germain of Silesia...

  11. El lenguaje de la violencia en el prólogo de la traducción latina del Corán impulsada por Pedro el Venerable

    OpenAIRE

    Martínez Gázquez, José

    2005-01-01

    En este artículo se presenta un análisis del prólogo escrito por Robert de Ketton a la traducción latina del Corán, realizada por mandato de Pedro el Venerable, abad de Cluny, en el que se muestra la mentalidad y la actitud agresiva y de violencia que mantienen los cristianos ante el islam a través del vocabulario empleado por el traductor Dans cet article, on cherche à montrer comment le prologue écrit par Robert de Ketton à la traduction latine du Coran, réalisée sur l’ordre de Pierre le...

  12. Industry leading satellite based GNSS (Global Navigation Satellite System) positioning and monitoring solutions with real-time CORS (Continuously Operating Reference Station) networks

    Science.gov (United States)

    Janousek, Martin

    2010-05-01

    Real-Time CORS (Continuously Operating Reference Station Networks) today are typically GNSS networks for positioning and monitoring purposes. Real-Time networks can consist of a few stations for a local network up to nation- or continental wide networks with several hundred CORS stations. Such networks use wide area modeling of GNSS error sources including ionospheric, tropospheric and satellite orbit correction parameters to produce highest precision and efficiency method of positioning using GNSS. In 1998 Trimble Navigation Ltd. introduced a method of surveying with a non-physical or computed base station, called VRS (Virtual Reference Station). It is the most widely supported method of producing a network solution for precise carrier phase positioning in the industry. Surveying historically required one base as the fixed point of reference, and one or multiple rovers using that point of reference to compute their location by processing a vector result, either in real-time or in a postprocessed sense. Real-time survey is often referred to as RTK, short for real-time kinematic, and as the name suggests the results are in real time and you can move. The power of VRS is in the ability to compute a real-time wide-area solution to the factors that cause single base methods to degrade with distance. Namely, ionospheric and tropospheric modeling, and satellite orbit corrections. This is achieved by the reference network of CORS. A wide scattering of CORS across a state, typically 50-70km in mid-latitudes, creates a ground based sampling which significantly reduces the distance dependent errors that accumulate in the single base-rover relationship described early. Furthermore, GNSS networks can be used for real-time monitoring purposes at various distance range. Trimble Integrity Manager software provides a suite of motion engines designed to detect and quantify any movement in a range of scales from slow, creeping movement like subsidence, through sudden events such as

  13. Farmacologia ocular aplicada no tratamento de doenças do vítreo, retina e coróide

    OpenAIRE

    Mello Filho, Paulo Augusto de Arruda [UNIFESP; Maia, Maurício [UNIFESP; Rodrigues,Eduardo Buchelle; Farah, Michel Eid

    2010-01-01

    As doenças que acometem o vítreo, retina e coróide são frequentes causas de cegueira irreversível em nosso meio. O aprofundamento do conhecimento científico permitiu o desenvolvimento de novos medicamentos com ação específica na patogênese dessas doenças, com resultados clínicos superiores aos obtidos no passado. O desenvolvimento da farmacologia ocular exige do médico oftalmologista conhecimentos específicos de biologia molecular, bioquímica e epidemiologia. Entretanto, o tratamento farmacol...

  14. 基于临界区划分的实时事务并发控制机制%COR-based Concurrency Control Strategies in the Real-time Transaction Model Supporting Functional Alternatives

    Institute of Scientific and Technical Information of China (English)

    夏家莉; 王文乐; 朱文婷; 曹重华

    2013-01-01

    针对支持功能替代的实时事务模型,根据替代做处理的数据对象将替代划分为若干个临界区,提出了临界区动态相容检测方法,提出了基于临界区动态相容的并发控制策略COR-CCS:分区封锁策略、支持预释放的封锁策略、按序提交策略和级联回滚策略,并给出了相应的并发控制实现算法.当实时系统中存在资源冲突时,若高优先级替代未完成的临界区与低优先级替代动态相容,可令二者并发执行.实验仿真结果证明,COR-CCS策略有利减少低优先级替代等待时间、提高系统成功率和CPU有效利用率.%In the real-time system model based on functional alternatives, we divided the alternatives into Critical Operation Regions (short for CORs) according to the data that they handled, and proposed the method to examine the dynamic compatibility between two CORs. Also, we present the strategies, named COR-CCS, that can improve the concurrence of the alternatives, such as: the strategy of locking each by COR, the strategy of pre-releasing lock, the strategy of orderly submitting and the strategy of cascaded roll-backing. After that we gave the algorithm of COR-based concurrency control. When scheduling the real-time system with data confliction, the alternatives can concurrently executed if the CORS in the alternative with higher priority is dynamic compatibility with the lower priority alternative. The experimental results showed that the COR-CCS is effect on reducing the waiting time of the lower priority alternatives, increasing the successful execution ratio of the transactions, and improving the CPU usage.

  15. Diplopia due to Dacryops

    OpenAIRE

    Rahmi Duman; Reşat Duman; Mehmet Balcı

    2013-01-01

    Dacryops is a lacrimal ductal cyst. It is known that it can cause globe displacement, motility restriction, and proptosis because of the mass effect. Diplopia due to dacryops has not been reported previously. Here, we present a 57-year-old man with binocular horizontal diplopia that occurred during left direction gaze due to dacryops.

  16. Diplopia due to Dacryops

    Directory of Open Access Journals (Sweden)

    Rahmi Duman

    2013-01-01

    Full Text Available Dacryops is a lacrimal ductal cyst. It is known that it can cause globe displacement, motility restriction, and proptosis because of the mass effect. Diplopia due to dacryops has not been reported previously. Here, we present a 57-year-old man with binocular horizontal diplopia that occurred during left direction gaze due to dacryops.

  17. Esquistossomose pulmonar. III. Forma crônica extensa com hipertensão pulmonar e na vigência de hipertensão portal associada a provável coroidite e retinite esquistossomótica

    Directory of Open Access Journals (Sweden)

    Jayme Neves

    1980-12-01

    Full Text Available Os Autores descrevem um caso grave de esquistossomose mansoni numa criança de 9 anos de idade (forma hepática com hipertensão portai associada a forma pulmonar com hipertensão pulmonar e cor pulmonale clinicamente caracterizado por episódios de insuficiência respiratória desencadeados em face de esforços físicos moderados. Sucessivos exames radiológicos de tórax revelaram comprometimento predominantemente arteriolar ao iado de uma micronodulação delicada e difusamente distribuída e configuração de cor pulmonale. Ao contrário do caso anteriormente descrito, a evolução se deu sem que se verificassem manifestações febris. Embora tenham sido afastadas várias hipóteses de associação da esquistossomose a concausas infectuosas, optou-se pelo tratamento de prova da tuberculose pulmonar. O fundo de olho também apresentava vários nódulos esbranquiçados disseminados pelo coróide e retina, caracterizando provável coroidite e retinite esquistossomótica. O tratamento antituberculoso resultou praticamente nulo. Não se procedeu ao tratamento específico da esquistossomose, considerando-se o alto risco da cardiopatia face aos esquistossomicidas disponíveis. A alta foi fornecida após treze meses de observação hospitalar. Não compareceu a ulterior controle.The Authors report a severe case of schistosomiasis mansoni in a 9-year-old child (heplus pulmonary form with pulmonary hypertension and cor pulmonalel The clinical features comprised episodes of respiratory insufficiency induced by moderate physical exercise. Serial chest X-raysshowed a predominantly arteriolar involvement associated with fine micronodules and the features of cor pulmonale. The fever episodes found in the case previously reported did not happen in th is patient. Even though various hypothesis of association of schistosomiasis and other infectious diseases were discarted, a trial of anti-tuberculous drugs was performed. Eye examination disclosed various

  18. Pulmonary Alveolar Microlithiasis - Clinico-Radiological dissociation - A case report with Radiological review.

    Science.gov (United States)

    Khaladkar, Sanjay Mhalasakant; Kondapavuluri, Sushen Kumar; Kamal, Anubhav; Kalra, Raghav; Kuber, Rajesh

    2016-01-01

    Pulmonary alveolar microlithiasis (PAM) is a rare chronic lung disease characterized by deposition of intra alveolar calcium and phosphate in bilateral lung parenchyma with predominance in lower and mid zones. Etiology and pathogenesis is not fully understood. However, mutation in SLC34A2 gene that encodes a sodium phosphate co-transporter in alveolar type-II cells resulting in formation and accumulation of microliths rich in calcium phosphate due to impaired clearance is considered the cause of disease. Patients with PAM are asymptomatic till development of hypoxemia and cor pulmonale. It remains static, while in some it progresses to pulmonary fibrosis, respiratory failure and cor pulmonale. We report a case of 44 year old male patient presenting with progressive shortness of breath on exertion for one year in duration with dry cough, more since last six months. Chest radiograph showed dense micronodular opacities giving classical sandstorm appearance. High resolution computed tomography (HRCT) showed microcalcification, subpleural cystic changes and calcified pleura. Lung biopsy showed calcospherites within alveolar spaces.

  19. Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.

    Directory of Open Access Journals (Sweden)

    Martina M A Muggenthaler

    2017-01-01

    Full Text Available Orofacial clefting is amongst the most common of birth defects, with both genetic and environmental components. Although numerous studies have been undertaken to investigate the complexities of the genetic etiology of this heterogeneous condition, this factor remains incompletely understood. Here, we describe mutations in the HYAL2 gene as a cause of syndromic orofacial clefting. HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated that the gene mutations destabilize the molecule, dramatically reducing HYAL2 protein levels. Consistent with the clinical presentation in affected individuals, investigations of Hyal2-/- mice revealed craniofacial abnormalities, including submucosal cleft palate. In addition, cor triatriatum sinister and hearing loss, identified in a proportion of Hyal2-/- mice, were also found as incompletely penetrant features in affected humans. Taken together our findings identify a new genetic cause of orofacial clefting in humans and mice, and define the first molecular cause of human cor triatriatum sinister, illustrating the fundamental importance of HYAL2 and hyaluronan turnover for normal human and mouse development.

  20. Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice

    Science.gov (United States)

    Hasan, S. Naimul; Mark, Brian; Harlalka, Gaurav V.; Patton, Michael A.; Ishida, Miho; Sharma, Sanjay; Faqeih, Eissa; Blakley, Brian; Jackson, Mike; Lees, Melissa; Dolinsky, Vernon; Cross, Leroy; Stanier, Philip; Salter, Claire; Baple, Emma L.; Crosby, Andrew H.

    2017-01-01

    Orofacial clefting is amongst the most common of birth defects, with both genetic and environmental components. Although numerous studies have been undertaken to investigate the complexities of the genetic etiology of this heterogeneous condition, this factor remains incompletely understood. Here, we describe mutations in the HYAL2 gene as a cause of syndromic orofacial clefting. HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix. Transfection assays demonstrated that the gene mutations destabilize the molecule, dramatically reducing HYAL2 protein levels. Consistent with the clinical presentation in affected individuals, investigations of Hyal2-/- mice revealed craniofacial abnormalities, including submucosal cleft palate. In addition, cor triatriatum sinister and hearing loss, identified in a proportion of Hyal2-/- mice, were also found as incompletely penetrant features in affected humans. Taken together our findings identify a new genetic cause of orofacial clefting in humans and mice, and define the first molecular cause of human cor triatriatum sinister, illustrating the fundamental importance of HYAL2 and hyaluronan turnover for normal human and mouse development. PMID:28081210

  1. Comparison between core temperatures measured telemetrically using the CorTemp® ingestible temperature sensor and rectal temperature in healthy Labrador retrievers.

    Science.gov (United States)

    Osinchuk, Stephanie; Taylor, Susan M; Shmon, Cindy L; Pharr, John; Campbell, John

    2014-10-01

    This study evaluated the CorTemp(®) ingestible telemetric core body temperature sensor in dogs, to establish the relationship between rectal temperature and telemetrically measured core body temperature at rest and during exercise, and to examine the effect of sensor location in the gastrointestinal (GI) tract on measured core temperature. CorTemp(®) sensors were administered orally to fasted Labrador retriever dogs and radiographs were taken to document sensor location. Core and rectal temperatures were monitored throughout the day in 6 resting dogs and during a 10-minute strenuous retrieving exercise in 6 dogs. Time required for the sensor to leave the stomach (120 to 610 min) was variable. Measured core temperature was consistently higher than rectal temperature across all GI locations but temperature differences based on GI location were not significant (P = 0.5218). Resting dogs had a core temperature that was on average 0.4°C above their rectal temperature with 95% limits of agreement (LoA) between 1.2°C and -0.5°C. Core temperature in exercising dogs was on average 0.3°C higher than their concurrent rectal temperature, with LoA of +1.6°C and -1.1°C.

  2. Proteinas do liquido cefalorraqueano: II. Valores normais das frações proteicas obtidas por eletroforese (variações ligadas a cor, sexo e idade

    Directory of Open Access Journals (Sweden)

    Lucia M. Singer Vermes

    1983-03-01

    Full Text Available Mediante dosagens de proteínas totais e eletroforese sobre acetato de celulose de 213 amostras de LCR normal, obtidas por punção da cisterna magna, foram efetuados estudos para verificação de variações ligadas à cor, sexo e idade. Os resultados obtidos permitiram concluir que: 1. não existem diferenças ligadas à cor no proteinograma do LCR; 2. em crianças, os fatores sexo e idade não influem nos valores estudados; 3. as taxas de proteínas totais e frações protéicas do LCR normal de criança diferem das de homens e de mulheres; 4. em adultos ocorrem variações ligadas ao sexo no proteinograma do LCR; 5. em adultos, proteínas totais e todas frações protéicas, quando expressas em mg/100 ml, aumentam com o avançar da idade. Foram estabelecidas, para a metodologia usada, as taxas fisiológicas do proteinograma do LCR de crianças, homens e mulheres, separadamente.

  3. Variação da Cor da Madeira de Teca em Função da Densidade e do Teor de Extrativos

    Directory of Open Access Journals (Sweden)

    Rosilei Aparecida Garcia

    Full Text Available RESUMO O objetivo deste estudo foi avaliar o efeito da densidade e do teor de extrativos na variação da cor da madeira de teca (Tectona grandis L. f. proveniente de plantios de diferentes espaçamentos. As análises colorimétricas foram realizadas nas faces radial e tangencial das madeiras de cerne e alburno com o espectrofotômetro CM 2600d no espaço de cor L*a*b*. A densidade e o teor de extrativos foram determinados segundo as normas ASTM D2395 e ASTM D1105. A madeira do maior espaçamento de plantio apresentou maior densidade e maior teor de extrativos. Na seção radial, as madeiras de cerne de maior densidade apresentaram mais pigmento amarelo, enquanto que na seção tangencial elas são mais escuras e apresentam menos pigmento amarelo. As madeiras de alburno de maior densidade são mais escuras e apresentam mais pigmento vermelho em ambas as seções. As madeiras mais escuras e com mais pigmento vermelho apresentaram um maior teor de extrativos.

  4. Teodoro Sampaio e Rui Barbosa no tabuleiro da política: estratégias e alianças de homens de cor (1880-1919

    Directory of Open Access Journals (Sweden)

    Wlamyra Albuquerque

    2015-06-01

    Full Text Available O artigo busca analisar, com base em episódios protagonizados por Teodoro Sampaio e Rui Barbosa, condições e forma de atuação política de homens de cor, entre 1880 e 1919. A trajetória de Sampaio nos permite perceber como um homem de cor, constituído num dos mais tradicionais redutos escravistas nas Américas, interpretou as relações e a gramática política que o forjaram como sujeito no pós-abolição. Teodoro Sampaio atravessou a década de 1880 buscando arregimentar recursos financeiros e políticos que garantissem a compra da alforria dos seus três irmãos e a consolidação da sua carreira de engenheiro. Já Rui Barbosa, branco, jurista, jornalista e político liberal, viveu o mesmo período empenhado na campanha emancipacionista e na luta abolicionista. Em 1919, Sampaio, já renomado, apoiou a campanha presidencial de Rui Barbosa. Naquela ocasião, o passado escravista e a cidadania da população negra justificaram as posições políticas de ambos. As fontes utilizadas são discursos, jornais, correspondência pessoal e inventários.

  5. Análise da Influência do Tratamento Preservativo na Cor e Rugosidade de Superfícies de Madeiras Tropicais

    Directory of Open Access Journals (Sweden)

    Ricardo Faustino Teles

    Full Text Available RESUMO Embora os tratamentos químicos aumentem a durabilidade da madeira, efeitos indiretos são obtidos com o emprego de alguns desses produtos, como a modificação da sua cor original e alterações em sua superfície. O objetivo do presente trabalho foi avaliar a superfície de três madeiras tropicais impregnadas com preservativo CCA por meio da colorimetria e da rugosidade. Três espécies de madeiras tropicais foram utilizadas, representando grupos de baixa, média e alta densidades. A cor de todas as madeiras foi alterada de forma significativa, ficando escuras, com diminuição dos pigmentos vermelhos e amarelos e com tendência ao esverdeamento da superfície. Com relação à rugosidade, todas as amostras apresentaram aumento da média aritmética da rugosidade (Ra e da média da altura máxima (Rz, aumentando a aspereza da superfície.

  6. Comparison of coronal electron density distributions from MLSO/MK4, STEREO/SECCHI-COR1, SOHO/LASCO-C2, and SOHO/UVCS

    Science.gov (United States)

    Lee, Jae-Ok; Cho, Kyung-Suk; Lee, Jin-Yi; Lee, Kyoung-Sun; Jang, Soojeong; Kim, Roksoon; Moon, Yong-Jae

    2017-08-01

    The coronal electron density is a fundamental and important physical quantity in solar physics. In this study, we compare coronal electron density distributions (CEDDs) derived from polarized brightness (pB) observations (MLSO/MK4 coronameter, STEREO/SECCHI-COR1 and SOHO/LASCO-C2 Coronagraphs) and one spectroscopic observation (SOHO/UVCS). For this, we consider data from January to August 2007 with the following conditions: the separation angle between the either of the STEREO spacecraft and Earth is less than 10 degrees and the observation time differences from one another are less than 1 minutes. In the pB observations, the CEDDs can be estimated by using inversion methods (Van de Hulst inversion for MK4 and LASCO-C2 pB data, and spherically symmetric polynomial approximation inversion for COR1 pB data). In the spectroscopic observation, we use the ratio of radiative and collisional components of the O vi doublet (O vi 1032 Å and 1037.6 Å) to estimate the CEDDs. We will show you some results about the estimated CEDDs and their dependence on different coronal regions such as backgournd corona and streamers.

  7. 基于区域CORS系统的全野外数字化测图方法探讨%Discussion on full-field digital mapping systems approach regional CORS

    Institute of Scientific and Technical Information of China (English)

    郭晓良; 杜会平

    2014-01-01

    基于区域CORS系统的全野外数字化测图,可以看做是GPS RTK测图方式的升级,其测图方式更加简便快捷,完全实现单人作业,工作效率成倍提升,因此,CORS系统一出现,就受到广大用户的欢迎。文章就基于区域CORS系统的全野外数字化测图方法进行探讨。%Based on full-field digital mapping system of regional CORS, it can be seen as a way to upgrade the GPS RTK Mapping. Its mapping easier and faster way fully realized single job, efficiency increase exponentially. Therefore, CORS system appeared, they were warmly welcomed. This paper discusses digital mapping method field area CORS system.

  8. Remoção de cor de efluentes têxteis com cogumelos Agaricus bispora = Decolorization of textile effluent with mushroom Agaricus bispora

    Directory of Open Access Journals (Sweden)

    Maria Alice Zarur Coelho

    2010-07-01

    Full Text Available O emprego direto de cogumelos Agaricus bispora foi avaliado para a remoção de cor de uma mistura sintética de corantes reativos. Avaliou-se o efeito da granulometria das partículas (cubos de 0,5 ou 1,0 cm e cogumelos moídos, da massa de cogumelos (10, 20, 40, 60 ou 80 g em 250 mL de solução e de diferentes formas de tratamento do cogumelo sobre a remoção de cor de uma solução sintética dos corantes Reactive Yellow 37, Reactive Black 5 e Reactive Red na concentração de 13,3 mg L-1 cada corante. Os melhores resultados foram obtidos para maiores áreas superficiais de contato do cogumelo (cogumelo moído com o efluente colorido e sob aeração contínua. A adição de acetona durante o processo de moagem, seguido de congelamento, contribuiu para o aumento da remoção de cor, obtendo-se os melhoresresultados: 73% após 6h, com 20 g de biocatalisador 250 mL-1 de efluente. A utilização de diferentes lotes e marcas de cogumelo levou à obtenção de diferentes atividades enzimáticas, mas percentuais similares de remoção de cor, indicando que a remoção de cor não possuirelação direta com a atividade enzimática.The direct application of Agaricus bispora mushroom was evaluated for decolorization of a synthetic mixture of reactive dyes. The effects of particle size (0.5 or 1.0 cm cubes and triturated mushroom, mushroom mass (10, 20, 40, 60 or 80 g in 250 mL of solution and different mushroom tissue treatments were analyzed regarding color removal efficiency of dyes Reactive Yellow 37, Reactive Black 5 and Reactive Red in a synthetic solution of 13.3 mg L-1 concentrationof each dye. The best results were found with larger superficial contact area between mushroom particle (triturated mushroom and colored effluent under continuous aeration. Acetone addition during mushroom trituration process followed by a freezing step contributed to decolorization improvement, leading to best results: 73% after 6h, with 20 g of biocatalyst 250 m

  9. Trouver la bonne distance : étrangère, marginale, ethnologue et parente en Corée du Sud

    Directory of Open Access Journals (Sweden)

    Élise Prébin

    2009-03-01

    Full Text Available Trouver la bonne distance : étrangère, marginale, ethnologue et parente en Corée du Sud. Cet article a pour sujet ma relation à la société sud-coréenne, non seulement en tant qu’anthropologue mais aussi en tant que personne adoptée d’origine coréenne. Il relate la manière dont plusieurs sortes de relations ont dû être gérées pendant le terrain. Il a fallu d’un côté me rapprocher de mes informateurs pour pouvoir mener un terrain classique dans une société inconnue, comprendre une culture autre et traiter un sujet relevant des sciences sociales : le retour des adoptés étrangers dans leur pays d’origine. De l’autre, il a fallu établir une bonne distance avec ma famille biologique coréenne en m’en éloignant momentanément. Ma relation avec elle était en effet instable du fait qu’elle reposait sur une contradiction : mon statut d’étrangère en dépit de l’intimité que supposaient les liens du sang. Pourtant, cette relation continue entre ma famille biologique et moi-même a éclairé certaines ambiguïtés relatives au statut des adoptés dans la société sud-coréenne que le temps limité du terrain n’avait pas permis de saisir. Cet article ébauche donc une réflexion épistémologique sur la pertinence d’éléments biographiques dans le traitement anthropologique de certains sujets. Je montre en l’occurrence comment le don en mariage d’une fille biologique adoptée conjure de manière satisfaisante un don en adoption toujours problématique.Finding the right distance: stranger, marginal, ethnologist and relative in south Korea. The topic of this article is my relation to the South Korean society, not only as a social anthropologist but also as a Korean adoptee. I relate the way I had to manage contrasted relations while conducting fieldwork. On one hand, I endeavoured to get closer to my informants in order to conduct classic fieldwork in an unknown society, to understand a different culture

  10. Due process traditionalism.

    Science.gov (United States)

    Sunstein, Cass R

    2008-06-01

    In important cases, the Supreme Court has limited the scope of "substantive due process" by reference to tradition, but it has yet to explain why it has done so. Due process traditionalism might be defended in several distinctive ways. The most ambitious defense draws on a set of ideas associated with Edmund Burke and Friedrich Hayek, who suggested that traditions have special credentials by virtue of their acceptance by many minds. But this defense runs into three problems. Those who have participated in a tradition may not have accepted any relevant proposition; they might suffer from a systematic bias; and they might have joined a cascade. An alternative defense sees due process traditionalism as a second-best substitute for two preferable alternatives: a purely procedural approach to the Due Process Clause, and an approach that gives legislatures the benefit of every reasonable doubt. But it is not clear that in these domains, the first-best approaches are especially attractive; and even if they are, the second-best may be an unacceptably crude substitute. The most plausible defense of due process traditionalism operates on rule-consequentialist grounds, with the suggestion that even if traditions are not great, they are often good, and judges do best if they defer to traditions rather than attempting to specify the content of "liberty" on their own. But the rule-consequentialist defense depends on controversial and probably false assumptions about the likely goodness of traditions and the institutional incapacities of judges.

  11. Chronic thromboembolic pulmonary hypertension: diagnostic impact of multislice-CT and selective pulmonary-DSA; Chronische thromboembolische pulmonale Hypertonie: diagnostische Wertigkeit von Mehrschicht-CT und selektiver Pulmonalis-DSA

    Energy Technology Data Exchange (ETDEWEB)

    Pitton, M.B.; Kemmerich, G.; Herber, S.; Schweden, F.; Thelen, M. [Mainz Univ. (Germany). Klinik fuer Radiologie; Mayer, E. [Mainz Univ. (Germany). Klinik fuer Herz-, Thorax- und Gefaesschirurgie

    2002-04-01

    Purpose: To evaluate the diagnostic impact of multislice-CT and selective pulmonary DSA in chronic thromboembolic pulmonary hypertension (CTEPH). Methods: 994 vessel segments of 14 consecutive patients with CTEPH were investigated with multislice-CT (slice thickness 3 mm, collimation 2.5 mm, reconstruction intervall 2 mm) and selective pulmonary DSA posterior-anterior, 45 oblique, and lateral projection. Analysis was performed by 2 investigators independently for CT and DSA. Diagnostic criteria were occlusions and non-occlusive changes like webs and bands, irregularities of the vessel wall, diameter reduction and thromboembolic depositions at different levels from central pulmonary arteries to subsegmental arteries. Reference diagnosis was made by synopsis of CT and DSA by consensus. Results: Concerning patency CT and DSA showed concordant findings overall in 88.9%, 92.9% for segmental arteries and 85.4% for subsegmental arteries. Concerning any thromboembolic changes, multislice-CT was significantly inferior to selective DSA (concordance 67.0% overall, 70.4% for segments and 63.6% for subsegments). Non-occlusive changes of the vessels were significantly underdiagnosed by CT (concordance of CT versus DSA: 23.1%). Conclusion: Multislice-CT and selective pulmonary DSA are equivalent for diagnosis of vessel occlusions at the level of segmental and subsegmental arteries. However, for visualisation of the non-occlusive thromboembolic changes of the vessel wall selective pulmonary DSA is still superior compared to multislice-CT. Multislice-CT and selective pulmonary DSA are complementary tools for diagnosis and treatment planning of chronic thromboembolic pulmonary hypertension (CTEPH). (orig.) [German] Fragestellung: Ueberpruefung der diagnostischen Aussage der Mehrschicht-CT im Vergleich zur selektiven Pulmonalis-DSA bei sehwerer thromboembolischer pulmonaler Hypertonie (CTEPH). Material und Methoden: Bei 14 konsekutiven Patienten mit CTPH wurden ein Mehrschicht-CT (SD

  12. Determinação da firmeza e cor do tomate (Lycopersicum esculentum mill), visando o estabelecimento de correlações entre medidas sensoriais e fisicas ao longo do tempo de maturação

    OpenAIRE

    Celina de Almeida

    1995-01-01

    Resumo: Tomates da cultivar Santa Clara 5300 foram estudados, durante a maturação, determinando-se cor e firmeza, através de métodos sensoriais e instrumentais, com o objetivo de verificara existênciade correlações entre estas medidas. A cor e firmezaforam avaliadas subjetivamentee sensorialmente, utilizando tomates uniformes,em função do tempo de maturação. Os frutos foram apresentados a um painel de nove voluntários treinados, marcando em escala não estruturada sua nota, para os dois paràme...

  13. Onycholysis due to trauma

    Directory of Open Access Journals (Sweden)

    Patricia Chang

    2014-04-01

    Full Text Available Female patient, 35 years old who came to the private office due to discoloration of her left thumbnail and little pain since 1 month ago. Clinical examination shows nail disease on her left thumbnail with onycholysis and dyschromia, dermatoscopy showed white-yellowish discoloration (Fig. 1A, B. The rest of the clinical examination was normal. Patient use to using acrylic nails since 2 years ago and denied some trauma at the nail. The diagnosis of onycholysis due to trauma was done and recommended her not to use acrylic nail, maintain the nail short and avoid wetness.

  14. Technical Due Diligence

    DEFF Research Database (Denmark)

    Jensen, Per Anker; Varano, Mattia

    2011-01-01

    Technical Due Diligence (TDD) as an evaluation of the performance of constructed facilities has become an important new field of practice for consultants. Before the financial crisis started in autumn 2008 it represented the fastest growing activity in some consulting companies. TDD is mostly car...

  15. Finite Element Analysis of X-cor Sandwich's Shear Strength%X-cor夹层结构剪切强度的有限元分析

    Institute of Scientific and Technical Information of China (English)

    党旭丹; 史少杰; 肖军

    2012-01-01

    The finite element software was used to analyze the shear strength and failure mechanism of X-cor sandwich structure. I)uring the shear strength analysis, the failure criterion and materials stiffness degradation rules were proposed, and the failure process and modes of X cor sandwich structure were also clarified. According to the failure criterion, the elemems with stiffness degradation and their distributions in the finite element mode/were used to simulate the types and propagation path of the failure. And the failure mechanism of X cor sandwich was explained. The results show that tinder shear load the resin regions fail first; and then the multiple failure modes of Z-pin pull out from the face-sheet, Z-pin shear off and Z-pin buckling appeared. The finite element results were consistent well with the values of test result after comparison, which meant that the failure criterion and stiffness degradation rules were effective.%利用有限元软件分析了X-cor夹层结构的剪切强度及失效机理,提出了失效判据和材料刚度退化规则.明确了X-cor夹层结构的失效过程和模式;根据失效判据,采用有限元模型中发生刚度退化的单元及其分布模拟失效类型及扩展路径,说明了X-cor夹层结构的剪切失效机理。结果表明:在剪切载荷下,树脂区首先失效,然后是Z-pin拔出面板、Z-pin被剪断及Z-pin屈曲多重失效模式并存;有限元分析结果与试验数值吻合较好,说明了失效判据和刚度退化规则选择的有效性。

  16. Efeito de diferentes fotopolimerizadores e meio de imersão na rugosidade e na cor de um compósito nanoparticulado

    Directory of Open Access Journals (Sweden)

    Suéllen Campos PLASTER

    Full Text Available Resumo Introdução O consumo excessivo de refrigerantes parece alterar as propriedades dos compósitos e essa alteração pode estar relacionada à unidade fotopolimerizadora. Objetivo Avaliar a alteração da rugosidade superficial (ΔR e da cor (ΔE de um compósito polimerizado por diferentes fotopolimerizadores, imerso em água destilada ou Coca-Cola®. Metodologia Sessenta amostras da resina nanoparticulada (FiltekMR Z350 XT, 3M foram distribuídas de acordo com as diferentes unidades de fotopolimerização: a luz halógena de quartzo-tungstênio-halogênio (QTH; b Luz de Emissão Diodo - LED 1 com ponteira de polímero; c LED 2 com ponteira de fibra ótica. Metade de cada grupo (n=10 foi mantida em água destilada ou imersa em Coca-Cola® 2×/dia por 20 minutos, durante 14 dias. Os dados foram submetidos aos testes Mann-Whitney e Kruskal-Wallis (p≤0,05. Resultado A ΔR não foi significante entre os grupos: em água: QTH = 0,006; LED 1 = 0,019; LED 2 = 0,010 (p=0,33; em refrigerante: QTH = 0,021; LED 1= 0,011; LED 2 = 0,030 (p=0,86. A ΔE não foi significativa entre os fotopolimerizadores: em água: QTH = 1,40; LED 1 = 1,80; LED 2 = 1,60 (p=0,31; em refrigerante: QTH = 2,51; LED 1= 1,91; LED 2 = 2,61 (p=0,41, mas foi significante comparando os meios de imersão (p=0,01, exceto para LED 1 (p=0,54. Conclusão As unidades fotopolimerizadoras não interferiram na rugosidade superficial e na cor da resina composta nanoparticulada. Os mergulhos diários em refrigerante não alteraram a lisura, mas alteraram a cor de modo visualmente perceptível, mas clinicamente aceitável, conforme os parâmetros da literatura científica.

  17. COR, VISCOSIDADE E BACTÉRIAS LÁCTICAS EM SUCO DE LARANJA PASTEURIZADO E SUBMETIDO AO EFEITO DA LUZ DURANTE O ARMAZENAMENTO

    Directory of Open Access Journals (Sweden)

    E. RAIMUNDO

    2008-11-01

    Full Text Available

    Este estudo avaliou as possíveis alterações em relação ao teor de ácido ascórbico (vitamina C, nos parâmetros de cor (CIE L*a*b*, na viscosidade e na contagem de bactérias lácticas que ocorrem no suco de laranja (C. sinensis L. Osbeck não pasteurizado e pasteurizado, armazenado com e sem incidência de luz. O suco de laranja foi pasteurizado a 90°C durante um minuto e armazenado em garrafas de vidro de 500 mL, previamente esterilizada a 100°C durante 30 min. As garrafas de vidro foram armazenadas a 8°C na ausência e na presença de luminosidade constante de 2.200 lux durante 60 dias. Periodicamente a cada 15 dias, foram analisados o teor de ácido ascórbico, parâmetros de cor (CIEL*a*b*, viscosidade e bactérias lácticas. Os resultados mostraram que ocorreu perda de 48,60; 40,02; 44,99 e 29,22% de ácido ascórbico, respectivamente para os sucos PCL (pasteurizado com luz, PSL (pasteurizado sem luz, NPCL (não pasteurizado com luz e NPSL (não pasteurizado sem luz até o 15º dia de armazenamento. O tratamento térmico modificou significativamente os parâmetros de cor do suco quando comparado ao não pasteurizado, embora o número de bactérias lácticas estivesse reduzido. As viscosidades dos sucos aumentaram 37,2; 21,65; 26,88 e 44,08% até o 30º dia de armazenamento, para PCL, PSL, NPCL e NPSL, respectivamente.

  18. Avaliação das alterações precoces na coróide e esclera ocorridas em coelhos hipercolesterolêmicos: estudo histológico e histomorfométrico Evaluation of choroid and sclera early alterations in hypercholesterolemic rabbits: histologic and histomorphometric study

    Directory of Open Access Journals (Sweden)

    Rogil José de Almeida Torres

    2009-02-01

    Full Text Available OBJETIVO: Demonstrar experimentalmente, através de exames histológicos e histomorfométricos, as alterações degenerativas da esclera e coróide desencadeadas precocemente pela dieta hipercolesterolêmica. MÉTODOS: Coelhos New Zealand foram organizados em dois grupos: GC (grupo controle, composto por 6 coelhos (6 olhos, recebeu dieta normal por 6 semanas; G1, composto por 12 coelhos (12 olhos, tratado previamente com ração colesterol a 1% (Sigma-Aldrich por 2 semanas e a partir do 14º dia com ração colesterol a 0,5% (Sigma-Aldrich. Os olhos foram submetidos à análise histológica, avaliados com corante de hematoxilina-eosina e ao exame morfométrico. A análise histomorfométrica foi realizada no setor posterior, adjacente ao disco óptico, e na periferia. RESULTADOS: O GC apresentou espessura média da esclera e coróide na periferia de 228,61 ± 31,71 micrômetros, enquanto na região posterior de aproximadamente 246,07 ± 25,66 micrômetros. No G1, observou-se espessura média da esclera e coróide na periferia de aproximadamente 303,56 ± 44,21 micrômetros, enquanto na região posterior de aproximadamente 295,59 ± 62,59. Houve diferença estatisticamente significativa da espessura da esclera e coróide entre os grupos na região periférica (pPURPOSE: To demonstrate experimentally, by means of histological and histomorphometric examinations, the sclera and choroid degenerative alterations, which take place at an early stage due to a hypercholesterolemic diet. METHODS: New Zealand rabbits were divided into two groups: CG (control group of 6 rabbits (6 eyes received a regular diet for 6 weeks; G1, of 12 rabbits (12 eyes, was first fed a 1% cholesterol diet (Sigma-Aldrich for 2 weeks and then from the 14th day on a 0.5% cholesterol diet (Sigma-Aldrich. The eyes underwent a histological analysis, stained with hematoxiline-eosine, and a morphometric examination. The histomorphometric analysis was performed in the posterior region

  19. A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II).

    Science.gov (United States)

    Apovian, Caroline M; Aronne, Louis; Rubino, Domenica; Still, Christopher; Wyatt, Holly; Burns, Colleen; Kim, Dennis; Dunayevich, Eduardo

    2013-05-01

    To examine the effects of naltrexone/bupropion (NB) combination therapy on weight and weight-related risk factors in overweight and obese participants. CONTRAVE Obesity Research-II (COR-II) was a double-blind, placebo-controlled study of 1,496 obese (BMI 30-45 kg/m(2) ) or overweight (27-45 kg/m(2) with dyslipidemia and/or hypertension) participants randomized 2:1 to combined naltrexone sustained-release (SR) (32 mg/day) plus bupropion SR (360 mg/day) (NB32) or placebo for up to 56 weeks. The co-primary endpoints were percent weight change and proportion achieving ≥ 5% weight loss at week 28. Significantly (P approach to the treatment of obesity, and may become a valuable new therapeutic option. Copyright © 2013 The Obesity Society.

  20. Termoterapia transpupilar como opção terapêutica para hemangioma circunscrito de coróide: relato de caso

    Directory of Open Access Journals (Sweden)

    Roizenblatt Jaime

    2002-01-01

    Full Text Available Os autores descrevem um caso de hemangioma circunscrito de coróide, com descolamento de retina associado, tratado por meio de termoterapia transpupilar com laser de diodo. Os parâmetros utilizados foram: 900 mW, mira de 4,2 mm, tempo de 3 minutos, lente QuadrAspheric (Volkâ com fator de magnificação de 1,97. Um mês após o tratamento ocorreu redução significativa do hemangioma, com recuperação integral da visão deste olho. São feitas considerações a respeito do método, o qual mostra-se promissor no tratamento destes tumores vasculares.

  1. Vésicules géantes décorées
    – adhésion et transport –

    OpenAIRE

    Puech, Pierre-Henri

    2005-01-01

    Les vésicules géantes sont souvent utilisées comme modèles des membranes cellulaires. On a ici examiné :1. leur adhésion spécifique via deux « colles moléculaires » :– colle faible : fragments terminaux EC12 de E-cadhréine. Cette protéineest impliquée dans la formation de tissus et dans de nombreux phénomènescancéreux. L'analyse statistique de l'adhésion bicouche supportée/vésiculedécorées par EC12 montre qu'existe une adhésion faible sensible au calcium et à une mutation des fragments ;– col...

  2. Research on CORS Engineering Survey Technology for the Guangzhou Industrial Park%广州某产业园CORS工程测量技术探讨

    Institute of Scientific and Technical Information of China (English)

    刘智超

    2013-01-01

    以单基站CORS在工程测量中的应用为研究对象,结合南方单基站的系统组成、系统设置及测量实践对其应用环节进行了详细地剖析.%Based on relevant work experience in engineering survey,this paper researches the engineering measurement using a single base station CORS,carries out a detailed analysis of its application link,and analyzes the southern single base station system components,system set tings and measurement practices.The full text is based on operating practices and it is beneficial for counterparts engaged in related work.

  3. X-cor夹层结构的力学性能试验研究%Experimental Study on Mechanical Properties of X-cor Sandwich

    Institute of Scientific and Technical Information of China (English)

    党旭丹; 张红松; 王新莉; 肖军; 陈海军

    2011-01-01

    X-cor夹层结构比强度高,比刚度大,有望取代传统蜂窝夹层结构作为航空航天器的主承力结构材料.采用真空固化成型工艺,通过改变Z-pin的植入参数制备了X-cor夹层结构,研究了Z-pin植入角度、植入间距和直径对其平压、剪切和拉伸性能的影响.研究结果表明,Z-pin的植入参数对X-cor夹层结构的力学性能影响显著.随Z-pin植入角度的增加X-cor夹层结构的平压性能降低,剪切性能增强,拉伸模量减小,拉伸强度先增加后减小.随Z-pin植入间距和直径增加,X-cor夹层结构力学性能均增加.与泡沫夹层结构相比,X-cor夹层结构压缩、剪切和拉伸模量的测试值分别提高了1.26~5.15倍、2.50~13.56倍和1.90~2.71倍,压缩、剪切和拉伸测试值分别提高了1.63~9.20倍、1.28~2.03倍和1.01~2.30倍.%X-cor sandwich has a high specific strength and specific stiffness and can be expected to replace the traditional honeycomb sandwich and become the main bearing loads structures of aircrafts. Through changing Z-pin's inserting parameters the Xcor sandwich was prepared with vacuum curing molding process. The effects of z-pin's inserting angle, inserting density and diameter on compression, shear and tension properties were studied. The results show that Z-pin's inserting parameters observably affect X-cor sandwich's mechanical properties. The compression properties of X-cor sandwich are reduced by the increase of Z-pin's inserting angle, and shear properties are improved by the increase of Z-pin's inserting angle. As Z-pin's inserting angle increase the tension modulus increases, while the tension strength firstly increases and secondly decreases. The mechanical properties increase with the increase of Zpin's inserting density and diameter. Compared with the foam sandwich, the experimental results of X-cor sandwich's compression, shear and tension modulus increase by 1. 26~5. 15, 2. 50~13.56 and 1.90~2. 71 times

  4. Cinética da degradação de carotenoides e da alteração de cor do azeite de pequi submetido ao aquecimento em temperatura de fritura

    Directory of Open Access Journals (Sweden)

    Mara Lina Rodrigues

    2013-08-01

    Full Text Available O azeite de pequi possui coloração vermelho-alaranjada devido à presença de carotenoides. Possíveis alterações químicas nesses compostos durante o processamento podem influenciar em modificações físicas do produto que ocorrem quando este é submetido ao aquecimento. Este estudo teve como objetivo utilizar parâmetros cinéticos para avaliar a degradação de carotenoides e a alteração de cor do azeite de pequi submetido ao aquecimento em temperatura de fritura. Para avaliar o efeito do aquecimento, o azeite de pequi foi tratado termicamente a 180°C em intervalo crescente de 10 minutos até uma hora de aquecimento. Realizaram-se as análises de carotenoides totais e cor e com esses resultados determinaram-se os parâmetros cinéticos. Ao longo do aquecimento, o teor de carotenoides foi praticamente todo degradado e consequentemente a cor foi bastante alterada. A cinética de degradação dos carotenoides foi de primeira ordem e da alteração de cor foi de ordem zero. Essas cinéticas refletiram as observações visuais das amostras do azeite de pequi obtidas depois de cada tratamento.

  5. EFEITO DE ADITIVOS SOBRE A COR DURANTE O ARMAZENAMENTO DE DOCES DE UMBU (SPONDIAS TUBEROSA ARR. CÂMARA VERDE E MADURO

    Directory of Open Access Journals (Sweden)

    Soraia Vilela BORGES

    2011-04-01

    Full Text Available O umbuzeiro (Spondias tuberosa Arr. Câmara é uma planta de grande valor econômico para a região semi-árida nordestina, muito utilizada na fabricação de doces em massa. Este trabalho teve como objetivo detectar as alterações de cor em diferentes formulações de doce de umbu verde e maduro, com adição de aditivos, durante 120 dias de armazenamento, sob condições controladas de temperatura e umidade (30ºC; U.R. 75% através dos parâmetros de cor instrumental L*, a* e b*. Em relação aos valores de L*, os resultados indicaram decréscimo ao longo do armazenamento, exceto nas formulações do doce de umbu maduro acrescentadas de xarope de glicose, devido ao brilho provocado por este aditivo. Para o doce de umbu verde o uso de goma xantana provocou o maior aumento de a* em relação às outras formulações; para o doce de umbu maduro as formulações com amido modifi cado, pectina e xarope de glicose apresentaram as maiores tendências ao acréscimo ao longo do tempo. No doce de umbu verde, os valores de b*diminuíram em todas as formulações, independente do aditivo utilizado. Já no doce maduro a maior perda ocorreu na formulação sem adição de aditivo concluindo-se que o uso de aditivo neste caso retardou a perda da coloração amarela.

  6. The maize CorA/MRS2/MGT-type Mg transporter, ZmMGT10, responses to magnesium deficiency and confers low magnesium tolerance in transgenic Arabidopsis.

    Science.gov (United States)

    Li, Hongyou; Wang, Ning; Ding, Jianzhou; Liu, Chan; Du, Hanmei; Huang, Kaifeng; Cao, Moju; Lu, Yanli; Gao, Shibin; Zhang, Suzhi

    2017-09-04

    ZmMGT10 was specifically expressed in maize roots and induced by a deficiency of magnesium. Overexpression of ZmMGT10 restored growth deficiency of the Salmonella typhimurium MM281 strain and enhanced the tolerance in Arabidopsis to stress induced by low magnesium levels by increasing uptake of Mg(2+) via roots. CorA/MRS2/MGT-type Mg(2+) transporters play a significant role in maintaining magnesium (Mg) homeostasis in plants. Although the maize CorA/MRS2/MGT family comprises of 12 members, currently no member has been functionally characterized. Here, we report the isolation and functional characterization of ZmMGT10 from the maize MRS2/MGT gene family. ZmMGT10 has a typical structure feature which includes two conserved TMs near the C-terminal end and an altered AMN tripeptide motif. The high sequence similarity and close phylogenetic relationship indicates that ZmMGT10 is probably the counterpart of Arabidopsis AtMGT6. The complementation of the Salmonella typhimurium mutated MM281 strain indicates that ZmMGT10 possesses the ability to transport Mg(2+). ZmMGT10 was specifically expressed in the plant roots and it can be stimulated by a deficiency of Mg. Transgenic Arabidopsis plants which overexpressed ZmMGT10 grew more vigorously than wild-type plants under low Mg conditions, exhibited by longer root length, higher plant fresh weight and chlorophyll content, suggesting ZmMGT10 was essential for plant growth and development under low Mg conditions. Further investigations found that high accumulation of Mg(2+) occurred in transgenic plants attributed to improved Mg(2+) uptake and thereby enhanced tolerance to Mg deficiency. Results from this investigation illustrate that ZmMGT10 is a Mg transporter of maize which can enhance the tolerance to Mg deficient conditions by improving Mg(2+) uptake in the transgenic plants of Arabidopsis.

  7. Research on Ionospheric VTEC Interpolation Algorithm Based on Chongqing Cors Network%基于重庆CORS网的电离层VTEC插值研究

    Institute of Scientific and Technical Information of China (English)

    崔书珍; 周金国; 李天和; 冯大福

    2016-01-01

    通过处理重庆 CORS 网的5个基准站观测数据,获得5个基准站上空电离层垂直总电子含量( VTEC)。利用其中的4个测站上空的VTEC采用克里金插值和反距离加权插值内插出另外一个测站上空VTEC。将插值结果及广义三角级数函数模型计算的电离层VTEC与实测VTEC进行比较,发现克里金插值和反距离加权插值的精度比广义三角级数函数计算的精度更高,更稳定;且克里金插值精度高于反距离加权插值。%Through processing of Chongqing CORS network five reference station observation data ionosphere verti-cal total electron content VTEC of the five base stations are obtained. The VTEC of the four stations are interpo-lated another station VTEC adopting Kriging interpolation and reverse distance weighted interpolation. Compared the interpolation results to the modeling results of generalized trigonometric series function to VTEC obtained from GPS observation data it is found that the accuracy of Kriging interpolation and inverse distance weighted interpola-tion is higher than the generalized trigonometric series function simulation and more stable. And the interpolation accuracy of Kriging is higher than inverse distance weighted.

  8. Clinical predictors of lacunar syndrome not due to lacunar infarction

    Directory of Open Access Journals (Sweden)

    Comes Emili

    2010-05-01

    Full Text Available Background Lacunar syndrome not due to lacunar infarct is poorly characterised. This single centre, retrospective study was conducted to describe the clinical characteristics of patients with lacunar syndrome not due to lacunar infarct and to identify clinical predictors of this variant of lacunar stroke. Methods A total of 146 patients with lacunar syndrome not due to lacunar infarction were included in the "Sagrat Cor Hospital of Barcelona Stroke Registry" during a period of 19 years (1986-2004. Data from stroke patients are entered in the stroke registry following a standardized protocol with 161 items regarding demographics, risk factors, clinical features, laboratory and neuroimaging data, complications and outcome. The characteristics of these 146 patients with lacunar syndrome not due to lacunar infarct were compared with those of the 733 patients with lacunar infarction. Results Lacunar syndrome not due to lacunar infarct accounted for 16.6% (146/879 of all cases of lacunar stroke. Subtypes of lacunar syndromes included pure motor stroke in 63 patients, sensorimotor stroke in 51, pure sensory stroke in 14, atypical lacunar syndrome in 9, ataxic hemiparesis in 5 and dysarthria-clumsy hand in 4. Valvular heart disease, atrial fibrillation, sudden onset, limb weakness and sensory symptoms were significantly more frequent among patients with lacunar syndrome not due to lacunar infarct than in those with lacunar infarction, whereas diabetes was less frequent. In the multivariate analysis, atrial fibrillation (OR = 4.62, sensorimotor stroke (OR = 4.05, limb weakness (OR = 2.09, sudden onset (OR = 2.06 and age (OR = 0.96 were independent predictors of lacunar syndrome not due to lacunar infarct. Conclusions Although lacunar syndromes are highly suggestive of small deep cerebral infarctions, lacunar syndromes not due to lacunar infarcts are found in 16.6% of cases. The presence of sensorimotor stroke, limb weakness and sudden onset in a patient

  9. Credit where due.

    Science.gov (United States)

    Friedman, Steven G

    2016-08-01

    The history of medicine is filled with stories of tireless researchers who failed to get credit for their hard work. Examples of this include Rosalind Franklin, who helped to elucidate the structure of DNA; Frederick Banting, who helped to discover insulin; and Jay McLean, who discovered heparin. The founding of the field of vascular surgery provides one of the most vivid examples of uncredited work. Even though Alexis Carrel was an unpaid, untitled assistant in Charles Guthrie's laboratory, it was Carrel alone who received a Nobel Prize for their work. In an attempt to give credit where due, the reasons for this injustice are described. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

  10. Unresolved major pulmonary embolism: Importance of follow-up lung scan in diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, H.S.; Intenzo, C.M.; Park, C.H.

    1986-09-01

    Unresolved major pulmonary embolism (UMPE) is an uncommon condition which causes pulmonary hypertension, cor pulmonale and death. An accurate and prompt diagnosis of UMPE is very important in the management of such patients with pulmonary embolectomy. Folow-up lung scans can lead to earlier diagnosis of UMPE, especially in patients who have a history of acute pulmonary embolism and present with pulmonary hypertension, respiratory insufficiency and cor pulmonale. We report a case of UMPE strongly suggested by follow-up lung scans and subsequently confirmed by pulmonary angiography and postmortem examination.

  11. Microdureza de resinas em função da cor e luz halógena Microhardness of resins as a function of color and halogen light

    Directory of Open Access Journals (Sweden)

    Fábio Martins

    2002-09-01

    Full Text Available O objetivo desse trabalho foi avaliar a influência da intensidade da luz e cor de uma resina composta no grau de dureza Knoop. Corpos-de-prova foram confeccionados utilizando-se matrizes de poliéster envoltas por um anel de cobre, contendo uma cavidade padronizada de 6 mm de diâmetro por 2 mm de espessura. Estas cavidades foram preenchidas com resina composta selecionada, Fill Magic - Vigodent, com as cores A3, B3, C3, D3 e I, fotopolimerizadas através de um fotopolimerizador Elipar, calibrado para produzir 3 intensidades de luz diferentes: 450 mW/cm², 800 mW/cm² e uma intensidade de luz crescente de 100 a 800 mW/cm². Foram confeccionados 90 corpos-de-prova em que o tempo de exposição da resina à luz halógena foi de 40 s. As amostras foram armazenadas em tubos de ensaio com água destilada a 37 ± 1ºC. Após este período, foram realizados os testes de dureza Knoop na região de superfície e fundo. Os resultados mostraram que houve diferença estatística em relação a intensidade de luz, entretanto em relação a cor, não houve diferença estatística. Os autores concluíram que a cor do compósito não influencia a dureza Knoop e que a intensidade progressiva promoveu os melhores resultados de dureza Knoop.The aim of this study was to evaluate the influence of light intensity and the influence of the color of a composite resin on Knoop hardness. Samples were confected utilizing polyester matrices with 6 mm of diameter and 2 mm of depth. The matrices were filled with composite resin (Fill Magic - Vigodent, colors A3, B3, C3, D3 and I, and light-cured by means of an Elipar light-curing unit in three different light intensities: 450 mW/cm2, 800 mW/cm² and an increasing intensity setup of 100 mW/cm² to 800 mW/cm². Ninety test specimens were confected, with the standard curing time of 40 seconds. The specimens were stored at 37 ± 1ºC and immersed in distillate water. The Knoop test was carried out in superficial and deep areas

  12. Efeitos da radiação gama na cor, capacidade antioxidante e perfil de ácidos graxos em amendoim (Arachis hypogaea L.

    Directory of Open Access Journals (Sweden)

    Adriano Costa de Camargo

    2011-03-01

    Full Text Available A irradiação gama é eficiente para eliminar a contaminação fúngica em grãos de amendoim. Este apresenta proteínas de alto valor biológico, minerais, vitaminas E, complexo B e alta concentração de lipídios. Este trabalho teve como objetivo avaliar o efeito da aplicação de radiações gama na cor, fenólicos totais, atividade antioxidante e perfil de ácidos graxos em amendoim (Arachis hypogaea L.. Os cultivares IAC-Tatu ST e IAC-Runner 886 foram submetidos a radiações gama com doses de 5,0; 7,5; 10,0; e 15,0 kGy e armazenados em temperatura ambiente. Não foram verificadas diferenças significativas na cor dos amendoins IAC-Tatu ST. Diferenças significativas foram detectadas para a luminosidade e o Croma do IAC-Runner 886. Os fenólicos totais diferiram significativamente entre o controle com 33,27 mg.g-1 e o tratamento com 10,0 kGy com 58,60 mg.g-1 no IAC-Tatu ST, neste parâmetro não foram observadas diferenças significativas no IAC-Runner 886, cujo controle foi 51,59 mg.g-1. Para atividade antioxidante não foi verificada diferença significativa com a dose de 10,0 kGy, recomendada para eliminação fúngica de amendoim. Na dose de 10,0 kGy, verificou-se a diminuição de ácidos graxos saturados, o aumento dos insaturados e o aumento de ácido linoleico. A relação oleico/linoleico diminuiu, justificando novos estudos correlacionando armazenamento e estabilidade oxidativa.

  13. Quasi-real time inversion method of three-dimensional epicenter coordinate, trigger time, and magnitude based on CORS

    Science.gov (United States)

    Xiao, Dongsheng; Chang, Ming; Su, Yong; Hu, Qijun; Yu, Bing

    2016-09-01

    This study explores the quasi-real time inversion principle and precision estimation of three-dimensional coordinates of the epicenter, trigger time and magnitude of earthquakes with the aim to improve traditional methods, which are flawed due to missing information or distortion in the seismograph records. The epicenter, trigger time and magnitude from the Lushan earthquake are inverted and analyzed based on high-frequency GNSS data. The inversion results achieved a high precision, which are consistent with the data published by the China Earthquake Administration. Moreover, it has been proven that the inversion method has good theoretical value and excellent application prospects.

  14. Stucs et décors sculptés de la fin de l’Antiquité au Moyen Âge (du Ve au XIIe siècle

    Directory of Open Access Journals (Sweden)

    Christian Sapin

    2005-10-01

    Full Text Available Le colloque “Stucs et décors de la fin de l’Antiquité au Moyen Âge (du Ve au XIIe siècle” s’est déroulé comme prévu à Poitiers entre le 16 et le 19 septembre 2004. Durant trois jours en salle et visites de sites, cette rencontre préparée par le CEM avec l’aide du CNRS, du CESCM (Centre d’études supérieures de civilisation médiévale et des collectivités territoriales a rassemblé 150 personnes et a permis de couvrir différents aspects de l’art du décor en stuc depuis l’Antiquité. Le lecteur r...

  15. Use of colour parameters for roasted coffee assessment Utilização dos parâmetros de cor para avaliação do café torrado

    Directory of Open Access Journals (Sweden)

    Natalina Cavaco Bicho

    2012-09-01

    Full Text Available Fast and non-destructive indicators were evaluated as tools to measure the technological quality of Arabica and Robusta coffee. Accordingly, considering the roasting intensity in highly valuable commercial samples, volume, mass, apparent density, moisture, total ash, ash insoluble in hydrochloric acid, and ether extract were characterized. The chromatic parameters L*, C*, Hº were measured using illuminants D65 and C. It was found that in roasted coffee beans, the parameters L*, C*, Hº, and coordinate b* had an antagonist interaction due to an increase in the roasting intensity, whereas after milling, only L* and Hº decreased progressively. Considering that the parameters L* and Hº followed similar patterns using both illuminants, D65 and C, it can be concluded that they are appropriate to evaluate coffee colour changes during roasting, enabling a relationship with coffee quality.Avaliaram-se indicadores não destrutivos e de execução rápida, para aferir a qualidade tecnológica de cafés Arábica e Robusta. Neste contexto, considerando a intensidade da torra em amostras com elevado interesse comercial, caracterizaram-se o volume, massa, densidade aparente, umidade, cinzas totais e insolúveis em ácido clorídrico e do extrato etéreo. Foram então analisados os parâmetros cromáticos L*, C*, Hº utilizando os iluminantes D65 e C. Verificou-se que em grãos de café torrado os parâmetros L*, C*, Hº e a coordenada b* mostraram uma interação antagônica face ao acréscimo da intensidade da torra, enquanto, após a moagem, apenas o L* e o Hº decresceram progressivamente. Considerando que a coordenada L* não variou significativamente com a aplicação dos dois iluminantes, concluiu-se que este parâmetro é o mais adequado para estudar a evolução da cor durante a torra, permitindo ainda estabelecer uma correlação com a qualidade.

  16. Cor da pele, distinções e cargos: Portugal e espaços atlânticos portugueses (séculos XVI a XVIII

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    João de Figueirôa-Rêgo

    2011-01-01

    Full Text Available Neste texto, analisa-se de que forma o centro político de Lisboa e as elites coloniais lidaram com a realidade da cor no espaço atlântico, sobretudo no que respeitava ao provimento de lugares e, inclusive, no acesso a distinções sociais de patamar intermédio; averigua-se o modo como o centro político fundamentou as suas perspectivas sobre a temática em diversas cronologias; tenta-se também sondar se nalguns locais a existência de sangue nativo no seio dos grupos sociais elevados terá alterado uma percepção simplista das variantes cromáticas. Como a questão abarcou, grosso modo, os tempos fortes (1570-1773 da vigência dos estatutos de pureza de sangue em Portugal, discute-se a possível conexão / contaminação entre essas duas realidades.

  17. ANALISA PERBANDINGAN KETELITIAN PENENTUAN POSISI DENGAN GPS RTK-NTRIP DENGAN BASE GPS CORS BIG DARI BERBAGAI MACAM MOBILE PROVIDER DIDASARKAN PADA PERGESERAN LINEAR (STUDI KASUS: SURABAYA

    Directory of Open Access Journals (Sweden)

    Atika Sari

    2015-02-01

    Full Text Available Penentuan posisi dalam pemetaan menggunakan penginderaan jauh dan foto udara memerlukan pengamatan GPS geodetik sebagai titik kontrol yang memilki ketelitian tinggi. Sistem koreksi data penentuan posisinya diperoleh dari transmisi data dari stasiun base ke receiver. Dalam perkembangan sekarang ini metode pengukuran RTK telah menggunakan metode NTRIP (Networked Transport of RTCM via Internet Protocol sebagai metode transmisi koreksi data dengan menggunakan intenet sehingga pengukuran tersebut masih bisa dilakukan dengan jarak yang lebih jauh dari base-nya. Pada metode NTRIP ini menggunakan metode pengiriman koreksi data GNSS melalui jaringan internet. Pengembangan sistem dengan fasilitas akses internet mobile melalui general packet radio service (GPRS dan global system for mobile (GSM, menyediakan metode cepat dan handal untuk mendistribusikan baris data GPS atau koreksi diferensial real-time (DGPS / RTK ke penerima GPS di daerah manapun yang berada di bawah jangkauan jaringan telepon seluler. Sehingga untuk mengetahui provider yang sesuai digunakan dalam wilayah surabaya dalam menggunakan metode RTK NTRIP maka dilakukanlah penelitian ini. Dari hasil pengamatan dari pengukuran dengan menggunakan  metode RTK-NTRIP dengan base GPS CORS BIG didapat nilai rata-rata dari masing-masing provider sekitar < 4 m.

  18. Conditions écophysiologiques de la survie dans la glace des oeufs de corégones du lac Baïkal

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    TCHERNIAEV G. A.

    1977-07-01

    Full Text Available Partant de la constatation que des œufs de corégones du lac Baïkal peuvent survivre et se développer dans la glace, l'auteur montre expérimentalement que des embryons ceillés survivent à des températures de — 4°C à condition que la vitesse de congélation soit rapide (en moins d'une heure. La température de 6°C est par contre léthale. Si la vitesse de congélation est lente (2 heures la mortalité est de 85 % à — 2°C et 98-99 % à — 4°C. L'auteur a aussi observé que le développement embryonnaire était plus rapide dans la glace du lac que dans des bouteilles de Zug en pisciculture et discute des possibilités d'action de l'énergie lumineuse.

  19. Choroid plexus papilloma and Aicardi syndrome: case report Papiloma do plexo coróideo e síndrome de Aicardi: relato de caso

    Directory of Open Access Journals (Sweden)

    Geraldo Pianetti Filho

    2002-12-01

    Full Text Available A case of Aicardi syndrome associated with a choroid plexus papilloma of the third and both lateral ventricles in a 15 months old baby girl is repported. The tumor was completely removed via three craniotomies. Reports of the literature with the association of choroid plexus papilloma and Aicardi syndrome are rare. We suggest that children diagnosed with Aicardi syndrome should routinely undergo imaging studies of the brain, such as computed tomography or magnetic resonance.Relatamos o caso de uma criança com 15 meses de idade, portadora da síndrome de Aicardi associada a tumores nos ventrículos laterais e terceiro ventrículo (papilomas que foram retirados cirurgicamente através de três craniotomias. A ocorrência de papiloma do plexo coróideo associada à sindrome de Aicardi é raramente descrita na literatura. Sugerimos que as crianças portadoras da síndrome de Aicardi sejam rotineiramente submetidas a estudo radiológico do encéfalo através da tomografia computadorizada ou ressonância nuclear.

  20. Guamán Poma de Ayala como traductor indígena de textos culturales: La Nueva Corónica y Buen Gobierno (c. 1615

    Directory of Open Access Journals (Sweden)

    Sabine Fritz

    2005-01-01

    Full Text Available La conquista y la colonización del reino de los incas (1532 pueden ser caracterizadas como un gigantesco acto de traducción entre diferentes textos culturales y distintos métodos de transmisión. Los traductores tenían una función mediadora entre conquistadores y conquistados en la sociedad colonial y desempeñaban un papel importante y poderoso en el proceso de oscilación de códigos culturales y de negociación de identidades y alteridades. Un ejemplo de traducción de textos culturales es la Nueva Corónica y Buen Gobierno (c 1615, escrita por Felipe Guamán Poma de Ayala. Este artículo analiza los textos culturales que conoce el autor y la posición en la que se ve a sí mismo. Por un lado, se muestra cómo funciona el proceso de transmisión de textos culturales andinos, originariamente de manera oral, al medio de la escritura; por otro lado, se llama la atención sobre las estructuras del poder subyacentes en el proceso de la traducción.

  1. La llegenda del cor menjat al Decameró de Boccacció: estratègies de traducció al català

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    Maribel Campmany Tarrés

    2013-12-01

    Full Text Available El grau d’intervenció del traductor determina l’acostament del text al lector. Amb la comparació de les quatre traduccions catalanes de La llegenda del cor menjat, el conte novè de la quarta jornada del Decameró de Giovanni Boccaccio, es pot comprovar que cada traductor utilitza estratègies diferents per mirar de resoldre un mateix problema de traducció. A més del bagatge cultural i la subjectivitat de cada un d’ells, cal tenir en compte un seguit de factors (temporals, històrics, referencials, lingüístics, socials, etc. que determinen el resultat final. The extent to which translators intervene in a text determines its approach to the reader. By comparing the four Catalan translations of The Legend of the Eaten Heart, the ninth tale of the fourth day of The Decameron by Giovanni Boccaccio, you can see that each translator uses different strategies to tackle the same translation problem. Besides each translator’s cultural background and subjectivity, one must take into account several factors (time, history, reference, language, society, etc., which might also affect the outcome.

  2. Development of a highly sensitive and robust Cor a 9 specific enzyme-linked immunosorbent assay for the detection of hazelnut traces.

    Science.gov (United States)

    Trashin, Stanislav A; Cucu, Tatiana; Devreese, Bart; Adriaens, Annemie; De Meulenaer, Bruno

    2011-12-05

    Allergy to tree nuts represents an acute health problem. Sensitized people can be inadvertently exposed to hidden allergens resulting from cross-contamination of foods. For this reason, reliable and highly sensitive analytical methods are needed to be developed for control and labeling of food ingredients and products. In the present paper we have proposed a new allergen specific sandwich-ELISA for hazelnut operated in optical and electrochemical modes. The ELISA was based on chicken egg yolk antibodies raised against a major hazelnut allergen, Cor a 9. The developed ELISA has a limit of detection in phosphate buffer of 4 ng mL(-1). No significant cross-reactivity with peanut, wheat or other food ingredients has been detected. Extracts of blank control cookies did not show any false positive response and the limit of detection in cookies was estimated to be 0.1 μg of hazelnut protein per g of food (0.1 ppm). The ELISA protocol was successfully adapted to operate in electrochemical mode and it was applied for the detection of hazelnut traces in cookies.

  3. Coréia: "Tigre" em turbulências, mistérios no norte Korea: "Tiger" in trouble, misteries from the north

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    Viktor Sukup

    2009-12-01

    Full Text Available O desenvolvimento industrial da Coréia do Sul nas últimas décadas foi impressionante, mesmo que várias crises graves, como a atual, ilustram certos pontos fracos, trata-se de um modelo econômico muito bem-sucedido em termos gerais. Este modelo é essencialmente uma combinação eficiente de mecanismos de mercado com forte intervenção do Estado. Porém, a liberalização financeira, introduzida a partir dos anos 80, contribuiu fortemente a lhe dar maior fragilidade.South Korea's industrial development in the last decades has been impressive. Even if several heavy crisis, like the present one, show some weak points of its economic model, it has been very successful. This model is essentially an efficient combination of market mechanisms with State interventionism, but the financial liberalization introduced since the 80s has strongly contributed to make it more fragile.

  4. Guilhem de Saint Gregori, "Ben grans avolesa intra" (BdT 233.2; Bartolomeo Zorzi, "En tal dezir mos cors intra" (BdT 74.4

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    Alessandro Bampa

    2014-02-01

    Full Text Available This paper provides a commentary and translation of two contrafacta of Arnaut Daniel’s sestina: Guilhem de Saint Gregori’s "Ben gran avolesa intra" and Bartolomeo Zorzi’s "En tal dezir mos cors intra". For the first song, I will highlight the new contexts and meanings given to Arnaut’s images (which are taken from his sestina and other poems within Guilhem’s invective against Aimers II of Poitiers, in order to evaluate its literary qualities and innovations. Through lexical analysis, this paper will reveal the strong connection between Zorzi’s and Guilhem’s songs. In particular, the paper analyses specifically their common theme of Hell, suggesting Bartolomeo’s text is most likely an answer to Arnaut’s sestina, which clearly expresses a desire of sensual pleasure. The study pays particular attention to the relation between sexual love and the matter of eternal damnation: Zorzi attacks Arnaut’s ferm voler, advancing his argument by evoking Chrétien de Troyes’ "Perceval" (references to which are spread throughout the text, and not only in l. 18 and through his constant stress on the duties towards one’s family.

  5. Color change using HSB color system of dental resin composites immersed in different common Amazon region beverages Alteração de cor de resinas compostas imersas em diferentes bebidas comuns da região Amazônica, utilizando o sistema de cor HSB

    Directory of Open Access Journals (Sweden)

    Débora da Costa e Silva

    2009-01-01

    Full Text Available The purpose of this study is to evaluate in vitro the color stability of composite resins when exposed to beverages with high coloring contents from the Amazon region. 240 samples from four different composite brands (Natural Look, Z350, 4Seasons and Opallis of hue A3 were fabricated using an acrylic matrix. The samples were stored in distilled water at 37ºC for 24 hours. The initial color (T0 was registered using a Canon EOS Rebel XTi 10 mp camera, and then the samples were divided into four groups (n=15: G1 (coffee, G2 (açaí juice, G3 (energetic guaraná and G4 (control - distilled water. The samples were exposed to solutions of DES (6hs and RE (18hs and placed in a double boiler under constant agitation, at 37ºC for 30 days. The samples were immersed in the coloring solutions for 15 minutes daily. After 7, 15 and 30 days, new photographic registers were made (T1, T2 and T3. The images were analyzed using Corel PHOTO-PAINT 12 software to identify the colors through the HSB system. The Kruskal-Wallis and t tests (pEste estudo propôs avaliar in vitro a estabilidade de cor de alguns compósitos quando expostos a bebidas da Região Amazônica com alto teor de corante. Foram confeccionados 240 corpos de prova (CP de quatro resinas (Natural Look, Z350, 4Seasons e Opallis no matiz A3 utilizando uma matriz de acrílico. As amostras foram armazenadas em água deionizada a 37ºC por 24 horas. A cor inicial das resinas (T0 foi registrada utilizando a máquina Canon EOS Rebel XTi 10Mp, e em seguida os CP foram divididos em 4 grupos (n=15: G1 (café, G2 (suco de açaí, G3 (guaraná energético e G4 (controle - água destilada. Os CP foram submetidos às soluções DES (6hs e RE (18hs e colocados em banho-maria, sob constante agitação, à temperatura de 37ºC durante 30 dias. Diariamente os corpos de prova foram imersos nas soluções corantes durante 15 minutos. Após 7, 15 e 30 dias realizaram-se novos registros fotográficos (T1, T2 e T3. As

  6. Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus Papilomas e carcinomas do plexo coróide: estudo histológico e imuno-histoquímico e comparação com plexo coróide fetal normal

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    Ana Silvia Carvalho de Menezes Barreto

    2004-09-01

    Full Text Available BACKGROUND: Choroid plexus tumors are rare. Results on immunohistochemical features are scanty and controversial even regarding normal plexus. METHOD: Thirteen cases of choroid plexus tumors and five samples of normal fetal choroid plexus were submitted to immunohistochemical study using a panel of epithelial, neuronal and stromal markers. RESULTS/CONCLUSIONS: Relevant histological findings were presence of clear cells in 3/5 papillomas (PP and 7/8 carcinomas (CA and all 5 fetal plexuses; rhabdoid cells, desmoplasia and vascular proliferation were found respectively in 3, 4 and 5 cases out of 6 poorly differentiated CA and were absent in PP and well differentiated CA. Pancytokeratin AE1/AE3 was strongly positive in all 13 cases, even in the undifferentiated component of poorly differentiated CA, where reactivity was focal in 3 and diffuse in 3 cases. Low molecular weight cytokeratin (35bH11 was not expressed in any of the 8 CA, but was present in all 5 PP. In 4 of 6 poorly differentiated CA there was reactivity for smooth muscle actin (1A4 in 10 to 30% of the cells. This was true also for one case lacking rhabdoid cells. Laminin was undetectable in all 6 cases of poorly differentiated CA but was present in 4 PP and 2 well differentiated CA. All 5 fetal plexuses expressed GFAP.CONTEXTO: Os tumores do plexo coróide são raros. Os resultados de dados imuno-histoquímicos são escassos e controversos, o mesmo valendo para o plexo coróide normal. MÉTODO: Treze casos de tumores do plexo coróide e cinco exemplares de plexo coróide fetal normal foram submetidos a estudo imuno-histoquímico, utilizando-se marcadores para antígenos epiteliais, neurais e estromais. RESULTADOS/CONCLUSÃO: Os achados histológicos mais relevantes foram células claras em 3/5 papilomas (PP e 7/8 carcinomas (CA e em todos os 5 plexos fetais; células rabdóides, desmoplasia e proliferação vascular foram encontradas, respectivamente, em 3, 4 e 5 casos de 6 CA pouco

  7. Lung diseases in the elderly. Pathogenetic significance of pollutants and environmental factors

    Energy Technology Data Exchange (ETDEWEB)

    Heitz, M.; Herzog, H.

    1984-05-03

    In the elderly pneumoconioses due to anorganic or organic dusts are not very common. The incidence of mesothelioma is increasing also in the elderly population. Mesothelioma has become the most frequent occupational malignancy. There is also evidence that mesothelioma can be produced by other fibers than asbestos particles. The paper discusses further the effect of passive smoking, where there is new evidence that passive-smokers are exposed to a higher risk for bronchial cancer than non-smokers. The interactions between smoking and air pollution and morbidity of chronic bronchitis are illustrated. New aspects of pathogenesis and pathophysiology of chronic obstructive lung disease and pulmonary emphysema due to smoking as the most frequent environmental lung disease in the elderly are further discussed. A brief overview of the therapeutical approach to chronic obstructive lung disease including new forms of treatment of cor pulmonale is finally given.

  8. Desigualdade educacional na ocorrência de obesidade abdominal por gênero e cor/raça: Estudo Pró-Saúde, 1999-2001 e 2011-2012

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    Ronaldo Fernandes Santos Alves

    2016-01-01

    Full Text Available Resumo Análise de dados seccionais do Estudo Pró-Saúde (1999-2001 e 2011-2012 revelou importante diferença de gênero e cor/raça na magnitude e variação temporal da desigualdade educacional na obesidade abdominal. Probabilidade de estar obeso foi gradativamente maior em mulheres (independentemente de cor/raça e homens (pardos/pretos menos escolarizados. Tais gradientes foram quantificados pelo índice relativo de desigualdade (IRD. Ao longo da década, observou-se redução da desigualdade em mulheres pardas/pretas (ΔIRD: 0,5; IC95%: 0,2-1,1, subjacente ao relativo aumento da prevalência de obesidade abdominal entre as mais escolarizadas. Houve estabilidade do IRD em mulheres brancas e homens pardos/pretos, indicando crescimento similar da prevalência de obesidade abdominal nos subgrupos educacionais. Associação da escolaridade com a ocorrência de obesidade abdominal sofreu interação múltipla de fatores sociodemográficos. Nossos resultados encorajam a estratificação conjunta por gênero e cor/raça no estudo das desigualdades socioeconômicas na ocorrência da obesidade abdominal.

  9. Cor, betacaroteno e colesterol em gema de ovos obtidos de poedeiras que receberam diferentes dietas Color, beta-caroten and cholesterol in yolks of eggs by different diets of laying hens

    Directory of Open Access Journals (Sweden)

    Luciana Marino e Biscaro

    2006-12-01

    Full Text Available O ovo é um alimento considerado nutricionalmente completo, e contém quantidade significativa de nutrientes. Para os consumidores, a qualidade deste alimento está relacionada com o prazo de validade do produto e com as características sensoriais, como cor da gema e da casca. Poucos estudos foram efetuados no Brasil sobre a utilização de agentes pigmentantes e seus efeitos sobre a coloração das gemas e proporção e qualidade química dos componentes do ovo. Com base nisso, objetivou-se com este trabalho relacionar diferentes dietas com cor, quantidade de betacaroteno e teor colesterol das gemas dos ovos. Foram coletados ovos de poedeiras que receberam 4 diferentes tipos de ração. A cor foi medida em colorímetro Minolta, o beta-caroteno separado em coluna e medido em espectrofotômetro e o colesterol extraído com clorofórmio e quantificado por método colorimétrico. Os resultados mostraram que não há relação entre a cor e aumento do teor de betacaroteno das gemas dos ovos, mas a alimentação alterou a cor da gema. O teor de colesterol foi diferente (pEgg is a nutritional complete food, and content significant quantity of nutrients. For the consumers, the food quality is related with validity date of product and with sensorial characteristics, like yolk color and hull. Few studies were done in Brazil about utilization of colorfull agents and theirs effects in yolk color and chemical quality of egg compounds. The objective of this research was related different feeds with the color, beta-carotene and cholesterol amount of egg yolk. Eggs were caught of laying hens that received 4 feed types. The color measure was done by Minolta colorimeter, beta-carotene separated by column and spectrophotometer and cholesterol separated with chloroform and measured by colorimetric method. The results showed that there is not a relation between the color an increase of beta-carotene amount in the yolks, but feed altered the yolk color. Cholesterol

  10. Pathophysiology and Toxicokinetic Studies of Blue-Green Algae Intoxication in the Swine Model

    Science.gov (United States)

    1991-06-26

    Wiley, New York, pp. 100 109. Fox, P. R. (1986) Cor pulmonale . In: Kirk, R. W. (ed.), Current Veterinary Therapy IX: Small Animal Practice, Vol. 9. W...es ind a Tra~ cor Norflhern 1:%M( 30H) . Nomninal parameters for data acquINitIol1 were 5WX daita Points. acýquis: ~ion timeTi 10 ins, low filter 0R5 It

  11. 基于非线性运动分析的CGCS2000下我国CORS站运动特征%Characteristics of the non-linear movement of CORS network in China based on the CGCS2000 frame

    Institute of Scientific and Technical Information of China (English)

    蒋志浩; 张鹏; 秘金钟; 李志才

    2012-01-01

    Non-linear movement of Chinese CORS network based on the CGCS2000 (Chinese geocentric 3D coordinate system) frame is mainly affected by the combined factors composed of non-tectonic crustal deformation signals, Common Mode Error (CME) in coordinate frame and error factor in observation. We can promote the accuracy and reliability of CORS network based on the analysis and modeling of the non-linear movement information in the CORS position time series. In this paper, we firstly use the international Earth satellite data and geophysical models to calculate non-tectonic crustal deformation in coordinate time series of CORS network based on the CGCS2000 caused by mass loading effects. Based on the quantitative analyses, we corrected the quantity of mass loading effects in the position time series of CORS stations. Secondly, after removing these surface mass loading effects, a spatial filtering algorithm based on principal component analysis is employed to remove the common mode errors of CGCS2000 from the daily position time series. Finally, the noise characteristic after mass loading correction and filtering is estimated quantitatively with the criterion of maximum likelihood estimation, and the annual speed and the actual accuracy of national CORS network are evaluated with the weighted least squares method.%CGCS2000(中国地心坐标系统2000)下CORS(全球导航卫星系统连续运行参考站)站的非线性运动主要受到地壳非构造形变信息、框架点公共误差信息和观测误差信息的组合影响,分析我国CORS站坐标时间序列中包含的非线性运动信息是维护CGCS2000坐标框架精确性、可靠性的基础.本文研究方法首先采用国际卫星对地观测数据及相关地球物理模型,计算了由质量负荷效应造成的地壳非构造形变,并以此修正了这些非构造形变对国家CORS站坐标时间序列的影响.其次采用主成分空间滤波算法(PCA)提取质量负荷改正后的CGCS2000

  12. STUDY OF SERUM ADIPONECTIN LEVELS IN TYPE 2 DIABETIC INDIVIDUALS & ITS COR R ELATION WITH BMI AND WAIST HIP RATIO

    Directory of Open Access Journals (Sweden)

    Arshiya

    2015-01-01

    Full Text Available Adipose tissue is not simply an inert storage depot for lipids but an important endocrine organ. It secretes many hormones called Adipocytokines which include Adiponectin , which increase insulin sensitivity , has an ti - inflammatory and anti atherogenic properties. OBJECTIVES: To study serum Adiponectin levels in type II DM individuals and compare the results with healthy controls and also to study the effect of BMI and WHR on serum Adiponectin levels. MATERIALS AND ME THOD: The study was carried out in seventy seven subjects who included 6 healthy male controls and 6 healthy female controls , 30 diabetic males and 35 diabetic female individuals. The healthy controls both male and female of age around 40 to 50 years (+5 years were selected with no history of diabetes or hypertension. The study group were selected of the same age as the control group from the Outpatient Department , Diabetology unit , of our Medical College. Individuals Height , Weight and Waist Hip Ratio we re measured and BMI was calculated with the formula - Weight in Kg/ Height in m². Estimation of serum Adiponectin with Human Adiponectin/Acrp 30 Immunoassay by Solid - phase ELISA which employs – Quantitative Sandwich Enzyme Immunoassay Technique. Plasma Gluc ose by GOD/POD method. RESULTS: The result shows that 1. Males have low levels of Adiponectin when compared to females which is not statistically significant and could be due to androgens like testosterone which inhibits the secretion of Adiponectin from a dipocytes. 2. Comparison of serum Adiponectin levels in type 2 DM subjects and healthy controls shows statistically significant decrease in Serum Adiponectin levels (P Value < 0.05 in type II DM subjects. 3. Negative correlation between serum Adiponectin and WHR and BMI but it is not statistically significant. CONCLUSION : Serum Adiponectin levels are decreased in Type II DM individuals. Adiponectin may be considered as one of the significant novel markers in

  13. Acoustic analysis of prosody in Sydenham's chorea Análise acústica da prosódia em coréia de Sydenham

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    Patrícia M Oliveira

    2010-10-01

    Full Text Available There are few studies of language and speech in patients with Sydenham's chorea (SC. We have done an acoustic analysis of fundamental frequency (F0, duration and intensity of declarative and interrogative sentences made by 20 SC patients, 20 patients with rheumatic fever (RF without chorea, and compared them with 20 healthy age-matched controls (CO. Each group included 12 females. We found that there is no difference between the RF and CO groups in all studied parameters. Patients with SC, however, presented with a speech characterized by decreased F0 range (difference between minimum and maximum F0, shorter duration of sentences, and higher intensity of the first syllable of sentences. The findings were not influenced by the nature of the sentences (i.e. , declarative or interrogative, but for all variables they were significantly more severe in males than females. In conclusion, we have demonstrated that patients with acute SC have an impairment of modulation of F0 and longer duration of emission of sentences, resulting in a monotone and slow speech. This pattern is similar to what has been described in other basal ganglia illnesses, such as Parkinson's disease, Huntington's disease and Wilson's disease.Há poucos estudos sobre linguagem e fala em pacientes com coréia de Sydenham (CS. Fizemos uma análise acústica da freqüência fundamental (F0, duração e intensidade de sentenças declarativas e interrogativas feitas por 20 pacientes com CS, 20 pacientes com febre reumática (FR sem coréia, comparando-os com 20 controles saudáveis e pareados por idade (CO. Cada grupo incluiu 12 mulheres. Foi encontrado que não há diferença entre os grupos FR e CO quanto a todos parâmetros estudados. Pacientes com CS, contudo, apresentaram-se com fala caracterizada pela redução da variação de F0 (diferença entre F0 mínima e máxima, duração mais curta das sentenças e maior intensidade da primeira sílaba das sentenças. Os achados não foram

  14. O desejo da liberdade e a participação de homens livres pobres e "de cor" na Independência do Brasil

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    Gladys Sabina Ribeiro

    Full Text Available A Independência do Brasil não fez parte da "lógica natural" dos fatos, vinculada a uma crise do Sistema Colonial que colocava a Colônia versus a Metrópole. Após o grito do Ipiranga, a imprensa e as autoridades, tanto em suas cartas pessoais como em suas correspondências de trabalho, tocavam no assunto de forma cuidadosa. Tentavam convencer aqueles que eram simpatizantes da "causa do Brasil" de que a independência como separação política era uma realidade a ser mantida. Um dos motivos alegados eram rebeliões das ruas de cidades como o Rio de Janeiro. As insurreições da população "de cor" da Corte não foram apenas uma ameaça constante, erigiram-se em realidade palpável nas fugas, nos ajuntamentos e nos tumultos, que não raro se transformaram em devassas e que pontilham a documentação da Polícia e do Ministério da Justiça. Os escravos e libertos participaram com igual intensidade da política do país e dos movimentos ocorridos. Fizeram uma leitura própria das idéias sobre a independência como autonomia, sobre a liberdade e sobre a libertação do jugo da reescravização, tentando colocá-las na prática em diferentes momentos.

  15. Justicia, misericordia y cristianismo: una relectura de las inscripciones coránicas de la Mezquita de Córdoba en el siglo X

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    Calvo Capilla, Susana

    2010-06-01

    Full Text Available This article is a new analysis of the Koranic inscriptions that were made on the doors of the Great Mosque at Cordova during the time of the Caliphate (10th century. Although not all these inscriptions are well-preserved, a new approach to the Koranic verses has revealed enough unique aspects to suggest a fresh interpretation of their meaning and intention. These inscriptions are part of a well-defined epigraphic program with a complex meaning related to the political, social and religious context of the time. This program also accounts for allusions to the anti-Christian polemic of the era. In this sense, the religious epigraphy of this mosque constitutes a valuable historical record of the Umayyad caliphate of al-Andalus.

    En este artículo se realiza una relectura de las inscripciones de carácter religioso de las puertas de la Mezquita de Córdoba en época califal. A pesar de que no todas se han conservado, el estudio de conjunto reveló suficientes elementos singulares como para sugerir nuevas hipótesis en torno al sentido y la intencionalidad de los textos coránicos escogidos. Las inscripciones, tanto interiores como exteriores, conforman un programa epigráfico perfectamente coherente y dotado de un complejo significado ligado al contexto político, social y religioso de la época. El programa incluye asimismo alusiones a la polémica anti-cristiana en el siglo x. En ese sentido, la mezquita cordobesa constituye un valioso documento histórico del Califato omeya de al-Andalus.

  16. Ultrastructural alterations of choroid plexuses of lateral ventricles of rats (Rattus norvegicus submitted to experimental chronic alcoholism Alterações ultraestruturais dos plexos coróides dos ventrículos laterais de ratos (Rattus norvegicus submetidos a alcoolismo crônico experimental

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    LUÍS FERNANDO TIRAPELLI

    2000-03-01

    Full Text Available Adult male rats (Wistar lineage were alcoholized with sugar cane liquor diluted at 30(0 GL during 300 days and sacrificed every 60 days in 5 stages. Samples of choroid plexuses of lateral ventricles were collected and examined at transmission electronic microscope to detect possible ultrastructural alterations and to raise possible pathological correlations. Gradual changes were observed in these animals during all the experiment: dilatation and enlargement of cisternae of Golgi complex, dilatation of RER, presence of digestive vacuoles and a large amount of pinocytic vesicles as well as vesicles with electronlucent content throughout cytoplasm, as well as an enlargement of intercellular space between basolateral interdigitation of the cells and of the connective tissue. The changes observed in the epithelium and connective tissue of choroid plexuses specially in 240 and 300 days of treatment are presumably due to a disturbance in hydroelectrolitic homeostasis, contributing to several morpho-functional disturbs of central nervous system. No changes were observed in the control group animals.Ratos machos adultos (linhagem Wistar foram alcoolizados com aguardente de cana diluída a 30(0 GL durante 300 dias e sacrificados a cada 60 dias em 5 etapas. Amostras dos plexos coróides dos ventrículos laterais foram coletadas e examinadas ao microscópio eletrônico de transmissão para detectar possíveis alterações ultraestruturais e suas correlações patológicas. Alterações graduais foram observadas nestes animais durante todo o experimento: dilatação e aumento das cisternas de complexo de Golgi, dilatação do retículo endoplasmático rugoso, presença de vacúolos digestivos e grande quantidade de vesículas pinocíticas assim como de vesículas de conteúdo elétron-lúcido por todo o citoplasma, além de aumento do espaço intercelular, entre as interdigitações das células assim como no tecido conjuntivo. As alterações observadas no

  17. Pulmonary arterial hypertension as a manifestation of lupus erythematosus

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    Stark, P.; Sargent, E.N.; Boylen, T.; Jaramillo, D.

    1987-08-01

    We present five patients with systemic lupus erythematosus (SLE) who developed pulmonary arterial hypertension and cor pulmonale in the course of their disease. The clinical features, as well as, the radiological manifestations of this rare manifestation of SLE are discussed. A vasculitic process is the most likely cause of this complication. Therapy is ineffective and the prognosis is poor.

  18. Pulmonary tumor thromboembolism: A case report and review of literature

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    Aiyappan Vinod

    2007-01-01

    Full Text Available Pulmonary tumor thromoembolism is well described in literature especially in patients known to have cancer. We are presenting this report of a patient presenting with Acute Cor-pulmonale secondary to Occult Gastric carcinoma causing pulmonary tumor embolism. This is an unusual presentation of occult neoplasm.

  19. Cardiovascular Complications in Chronic Obstructive Pulmonary Disease with Reference to 2D Echocardiography Findings

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    Vikram B Vikhe

    2013-08-01

    Results: Emphysema and chronic bronchitis was present in 38% and 62% respectively. Echocardiographic evidence of cor-pulmonale and pulmonary hypertension was found in 70% of the patients. Conclusions: Echocardiography is more sensitive than electrocardiography in detecting PAH and right ventricular dysfunction in COPD. [Natl J Med Res 2013; 3(4.000: 385-388

  20. Pulmonary alveolar microlithiasis

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    Surender Kashyap

    2013-01-01

    Full Text Available Pulmonary alveolar microlithiasis (PAM is a rare, chronic lung disease with bilateral intra-alveolar calcium and phosphate deposition throughout the lung parenchyma with predominance to lower and midzone. Although, etiology and pathogenesis of PAM is not fully understood, the mutation in SLC34A2 gene that encodes a sodium-phosphate co-transporter in alveolar type II cells resulting in the accumulation and forming of microliths rich in calcium phosphate (due to impaired clearance are considered to be the cause of the disease. Chest radiograph and high-resolution CT of thorax are nearly pathognomonic for diagnosing PAM. HRCT demonstrates diffuse micronodules showing slight perilobular predominance resulting in calcification of interlobular septa. Patients with PAM are asymptomatic till development of hypoxemia and cor-pulmonale. No therapy has been proven to be beneficial except lung transplantation.