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Sample records for coordinates membrane specialization

  1. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes

    NARCIS (Netherlands)

    C.C. Hoogenraad (Casper); I. Popa (Ioana); K. Futai (Kensuke); E. Sanchez-Martinez (Emma); P. Wulf (Phebe); T. van Vlijmen (Thijs); B.R. Dortland (Bjorn); V. Oorschot (Viola); R. Govers (Robert); M. Monti (Maria); A.J.R. Heck (Albert); M. Sheng (Morgan); J. Klumperman (Judith); H. Rehmann (Holger); D. Jaarsma (Dick); L.C. Kapitein (Lukas); P. van der Sluijs

    2010-01-01

    textabstractThe endosomal pathway in neuronal dendrites is essential for membrane receptor trafficking and proper synaptic function and plasticity. However, the molecular mechanisms that organize specific endocytic trafficking routes are poorly understood. Here, we identify GRIP-associated protein-1

  2. 47 CFR 25.251 - Special requirements for coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Special requirements for coordination. 25.251... SATELLITE COMMUNICATIONS Technical Standards § 25.251 Special requirements for coordination. (a) The administrative aspects of the coordination process are set forth in § 101.103 of this chapter in the case...

  3. ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.

    Science.gov (United States)

    Daley, William P; Gervais, Elise M; Centanni, Samuel W; Gulfo, Kathryn M; Nelson, Deirdre A; Larsen, Melinda

    2012-01-01

    The basement membrane is crucial for epithelial tissue organization and function. However, the mechanisms by which basement membrane is restricted to the basal periphery of epithelial tissues and the basement membrane-mediated signals that regulate coordinated tissue organization are not well defined. Here, we report that Rho kinase (ROCK) controls coordinated tissue organization by restricting basement membrane to the epithelial basal periphery in developing mouse submandibular salivary glands, and that ROCK inhibition results in accumulation of ectopic basement membrane throughout the epithelial compartment. ROCK-regulated restriction of PAR-1b (MARK2) localization in the outer basal epithelial cell layer is required for basement membrane positioning at the tissue periphery. PAR-1b is specifically required for basement membrane deposition, as inhibition of PAR-1b kinase activity prevents basement membrane deposition and disrupts overall tissue organization, and suppression of PAR-1b together with ROCK inhibition prevents interior accumulations of basement membrane. Conversely, ectopic overexpression of wild-type PAR-1b results in ectopic interior basement membrane deposition. Significantly, culture of salivary epithelial cells on exogenous basement membrane rescues epithelial organization in the presence of ROCK1 or PAR-1b inhibition, and this basement membrane-mediated rescue requires functional integrin β1 to maintain epithelial cell-cell adhesions. Taken together, these studies indicate that ROCK1/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.

  4. Membrane fouling and wetting in membrane distillation and their mitigation by novel membranes with special wettability.

    Science.gov (United States)

    Wang, Zhangxin; Lin, Shihong

    2017-04-01

    Membrane distillation (MD) has been identified as a promising technology to desalinate the hypersaline wastewaters from fracking and other industries. However, conventional hydrophobic MD membranes are highly susceptible to fouling and/or wetting by the hydrophobic and/or amphiphilic constituents in these wastewaters of complex compositions. This study systematically investigates the impact of the surface wetting properties on the membrane wetting and/or fouling behaviors in MD. Specifically, we compare the wetting and fouling resistance of three types of membranes of different wetting properties, including hydrophobic and omniphobic membranes as well as composite membranes with a hydrophobic substrate and a superhydrophilic top surface. We challenged the MD membranes with hypersaline feed solutions that contained a relatively high concentration of crude oil with and without added synthetic surfactants, Triton X-100. We found that the composite membranes with superhydrophilic top surface were robustly resistant to oil fouling in the absence of Triton X-100, but were subject to pore wetting in the presence of Triton X-100. On the other hand, the omniphobic membranes were easily fouled by oil-in-water emulsion without Triton X-100, but successfully sustained stable MD performance with Triton X-100 stabilized oil-in-water emulsion as the feed solution. In contrast, the conventional hydrophobic membranes failed readily regardless whether Triton X-100 was present, although via different mechanisms. These findings are corroborated by contact angle measures as well as oil-probe force spectroscopy. This study provides a holistic picture regarding how a hydrophobic membrane fails in MD and how we can leverage membranes with special wettability to prevent membrane failure in MD operations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Special Education and General Education--Coordinated or Separated? A Study of Curriculum Planning for Pupils with Special Educational Needs

    Science.gov (United States)

    Nilsen, Sven

    2017-01-01

    The central issue of this article is the coordination between special and general education in curriculum planning for pupils with special educational needs. The focus is on individual education plans (IEPs) in special education and work plans in general education. This is also viewed in relation to how special and general education teachers…

  6. Local Palmitoylation Cycles and Specialized Membrane Domain Organization

    DEFF Research Database (Denmark)

    Fukata, Yuko; Murakami, Tatsuro; Yokoi, Norihiko

    2016-01-01

    Palmitoylation is an evolutionally conserved lipid modification of proteins. Dynamic and reversible palmitoylation controls a wide range of molecular and cellular properties of proteins including the protein trafficking, protein function, protein stability, and specialized membrane domain organiz...

  7. Axon Membrane Skeleton Structure is Optimized for Coordinated Sodium Propagation

    CERN Document Server

    Zhang, Yihao; Li, He; Tzingounis, Anastasios V; Lykotrafitis, George

    2016-01-01

    Axons transmit action potentials with high fidelity and minimal jitter. This unique capability is likely the result of the spatiotemporal arrangement of sodium channels along the axon. Super-resolution microscopy recently revealed that the axon membrane skeleton is structured as a series of actin rings connected by spectrin filaments that are held under entropic tension. Sodium channels also exhibit a periodic distribution pattern, as they bind to ankyrin G, which associates with spectrin. Here, we elucidate the relationship between the axon membrane skeleton structure and the function of the axon. By combining cytoskeletal dynamics and continuum diffusion modeling, we show that spectrin filaments under tension minimize the thermal fluctuations of sodium channels and prevent overlap of neighboring channel trajectories. Importantly, this axon skeletal arrangement allows for a highly reproducible band-like activation of sodium channels leading to coordinated sodium propagation along the axon.

  8. 15 CFR Appendix Vi to Subpart P of... - Special-Use Areas Boundary Coordinates and Use Designations

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Special-Use Areas Boundary Coordinates...—Special-Use Areas Boundary Coordinates and Use Designations The boundary of each of the Special-Use is formed by connecting in succession the points at the following coordinates: Conch Reef (Research...

  9. Special coordinate systems in pseudo-Finsler geometry and the equivalence principle

    CERN Document Server

    Minguzzi, E

    2016-01-01

    Special coordinate systems are constructed in a neighborhood of a point or of a curve. Taylor expansions can then be easily inferred for the metric, the connection, or the Finsler Lagrangian in terms of curvature invariants. These coordinates circumvent the difficulties of the normal and Fermi coordinates in Finsler geometry, which in general are not sufficiently differentiable. They are obtained applying the usual constructions to the pullback of a horizontally torsionless connection. The results so obtained are easily specialized to the Berwald or Chern-Rund connections and have application in the study of the equivalence principle in Finslerian extensions of general relativity.

  10. The Standards Agenda: Reflections of a Special Educational Needs Co-ordinator

    Science.gov (United States)

    Glazzard, Jonathan

    2014-01-01

    This study is a life history account of Bev, a special educational needs co-ordinator who works in a primary school in England. The research examines how, within Bev's experiences, the discourses of integration and inclusion have affected learners with special educational needs. Additionally, the study examines the impact of the…

  11. The Standards Agenda: Reflections of a Special Educational Needs Co-ordinator

    Science.gov (United States)

    Glazzard, Jonathan

    2014-01-01

    This study is a life history account of Bev, a special educational needs co-ordinator who works in a primary school in England. The research examines how, within Bev's experiences, the discourses of integration and inclusion have affected learners with special educational needs. Additionally, the study examines the impact of the…

  12. Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

    NARCIS (Netherlands)

    Gray, A.N.; Egan, A.J.F.; van 't Veer, I.L.; Verheul, J.; Colavin, A.; Koumoutsi, A.; Biboy, J.; Altelaar, A.F.M.; Damen, M.J.; Huang, K.C.; Simorre, J.P.; Breukink, E.; den Blaauwen, T.; Typas, A.; Gross, C.A.; Vollmer, W.

    2015-01-01

    To maintain cellular structure and integrity during division, Gram-negative bacteria must carefully coordinate constriction of a tripartite cell envelope of inner membrane, peptidoglycan (PG), and outer membrane (OM). It has remained enigmatic how this is accomplished. Here, we show that envelope ma

  13. Simulations of Pore Formation in Lipid Membranes: Reaction Coordinates, Convergence, Hysteresis, and Finite-Size Effects.

    Science.gov (United States)

    Awasthi, Neha; Hub, Jochen S

    2016-07-12

    Transmembrane pores play an important role in various biophysical processes such as membrane permeation, membrane fusion, and antimicrobial peptide activity. In principal, all-atom molecular dynamics (MD) simulations provide an accurate model of pore formation in lipid membranes. However, the free energy landscape of transmembrane pore formation remains poorly understood, partly because potential of mean force (PMF) calculations of pore formation strongly depend on the choice of the reaction coordinate. In this study, we used umbrella sampling to compute PMFs for pore formation using three different reaction coordinates, namely, (i) a coordinate that steers the lipids in the lateral direction away from the pore center, (ii) the distance of a single lipid phosphate group from the membrane center, and (iii) the average water density inside a membrane-spanning cylinder. Our results show that while the three reaction coordinates efficiently form pores in membranes, they suffer from strong hysteresis between pore-opening and pore-closing simulations, suggesting that they do not restrain the systems close to the transition state for pore formation. The two reaction coordinates that act via restraining the lipids lead to more pronounced hysteresis compared with the coordinate acting on the water molecules. By comparing PMFs computed from membranes with different numbers of lipids, we observed significant artifacts from the periodic boundary conditions in small simulation systems. Further analysis suggests that the formation and disruption of a continuous hydrogen-bonding network across the membrane corresponds to the transition state for pore formation. Our study provides molecular insights into the critical steps of transmembrane pore formation, and it may guide the development of efficient reaction coordinates for pore formation.

  14. Educating Leaders for Social Justice: The Case of Special Educational Needs Co-Ordinators

    Science.gov (United States)

    Liasidou, Anastasia; Svensson, Cathy

    2014-01-01

    In the light of policy imperatives to initiate and maintain inclusive education reforms, the role of special educational needs co-ordinators (SENCOs) in England and Wales should be reconceptualised with a view to their leading school reforms commensurate with the principles of an inclusive discourse. The article concentrates on the social justice…

  15. Short Sprint or an Endurance Test: The Perceived Impact of the National Award for Special Educational Needs Coordination

    Science.gov (United States)

    Brown, Julian; Doveston, Mary

    2014-01-01

    This paper evaluates the perceived impact of the National Award (NA) for Special Educational Needs (SEN) Coordination in English mainstream schools. The Award was introduced in 2009 and has been mandatory for all new Special Educational Needs Coordinators (SENCos) since its inception. The framework used for the evaluation is based on the learning…

  16. Program for coordinated dental care under general anaesthesia for children with special needs.

    Science.gov (United States)

    de Nova-García, M Joaquín; Martínez, M Rosa Mourelle; Sanjuán, Carmen Martín; López, Nuria E Gallardo; Cabaleiro, Esther Carracedo; García, Yolanda Alonso

    2007-12-01

    To draw up a program for coordination of dental care for children with special needs between the Course at the Universidad Complutense de Madrid (UCMC) (Specialisation in holistic dental care for children with special needs), and the Disabled Children's Oral Health Unit (DCOHU) within the Madrid Health Service (SERMAS). UCMC Protocol for children with special needs. Design of a clinical pathway based on consensus amongst the professionals involved. Algorithm for dental care for children with special needs. Matrix covering all activities and timing for full dental diagnosis in such patients (general health, oral health and behaviour) to facilitate proper referral of patients requiring general anaesthesia. Inclusion in the matrix of those responsible for each activity. Improved team work (University - primary health care) in patient evaluation, in provision of information to parents and guardians and in health care quality. From the teaching point of view, students learn to adopt a systematic approach in the decision-making process.

  17. Coordination of copper to the membrane-bound form of α-synuclein.

    Science.gov (United States)

    Dudzik, Christopher G; Walter, Eric D; Abrams, Benjamin S; Jurica, Melissa S; Millhauser, Glenn L

    2013-01-08

    Aggregation of the 140-amino acid protein α-synuclein (α-syn) is linked to the development of Parkinson's disease (PD). α-Syn is a copper binding protein with potential function as a regulator of metal-dependent redox activity. Epidemiological studies suggest that human exposure to excess copper increases the incidence of PD. α-Syn exists in both solution and membrane-bound forms. Previous work evaluated the Cu(2+) uptake for α-syn in solution and identified Met1-Asp2 and His50 as primary contributors to the coordination shell, with a dissociation constant of approximately 0.1 nM. When bound to the membrane bilayer, α-syn takes on a predominantly helical conformation, which spatially separates His50 from the N-terminus of the protein and is therefore incompatible with the copper coordination geometry of the solution state. Here we use circular dichroism and electron paramagnetic resonance (continuous wave and pulsed) to evaluate the coordination of copper to the membrane-bound form of α-syn. In this molecular environment, Cu(2+) binds exclusively to the N-terminus of the protein (Met1-Asp2) with no participation from His50. Copper does not alter the membrane-bound α-syn conformation or enhance the release of the protein from the bilayer. The Cu(2+) affinity is similar to that identified for solution α-syn, suggesting that copper coordination is retained in the membrane. Consideration of these results demonstrates that copper exerts its greatest conformational effect on the solution form of α-syn.

  18. Coordination of Copper to the Membrane-Bound Form of α-Synuclein

    Energy Technology Data Exchange (ETDEWEB)

    Dudzik, Christopher G.; Walter, Eric D.; Abrams, Benjamin S.; Jurica, Melissa S.; Millhauser, Glenn L.

    2013-01-01

    Aggregation of the 140 amino acid protein α-synuclein (α-syn) is linked to the development of Parkinson's disease (PD). α-Syn is a copper binding protein with potential function as a regulator of metal dependent redox activity. Epidemiological studies suggest that human exposure to excess copper increases the incidence of PD. α-Syn exists in both solution and membrane bound forms. Previous work evaluated the Cu2+ uptake for α-syn in solution and identified Met1-Asp2 and His50 as primary contributors to the coordination shell, with a dissociation constant of approximately 0.1 nM. When bound to the membrane bilayer, α-syn takes on a predominantly helical conformation, which spatially separates His50 from the protein N-terminus and is therefore incompatible with the copper coordination geometry of the solution state. Here we use circular dichroism and electron paramagnetic resonance (continuous wave and pulsed) to evaluate copper coordination to the membrane bound form of α-syn. In this molecular environment, Cu2+ binds exclusively to the protein N-terminus (Met1-Asp2) with no participation from His50. Copper does not alter the membrane bound α-syn conformation, or enhance the protein's release from the bilayer. The Cu2+ affinity is similar to that identified for solution α-syn suggesting that copper coordination is retained in the membrane. Consideration of these results suggests that copper exerts its greatest conformational affect on the solution form of α-syn and this species may therefore be precursor to PD arising from environmental copper exposure.

  19. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells

    Science.gov (United States)

    Kiyonaka, Shigeki; Kubota, Ryou; Michibata, Yukiko; Sakakura, Masayoshi; Takahashi, Hideo; Numata, Tomohiro; Inoue, Ryuji; Yuzaki, Michisuke; Hamachi, Itaru

    2016-10-01

    The controlled activation of proteins in living cells is an important goal in protein-design research, but to introduce an artificial activation switch into membrane proteins through rational design is a significant challenge because of the structural and functional complexity of such proteins. Here we report the allosteric activation of two types of membrane-bound neurotransmitter receptors, the ion-channel type and the G-protein-coupled glutamate receptors, using coordination chemistry in living cells. The high programmability of coordination chemistry enabled two His mutations, which act as an artificial allosteric site, to be semirationally incorporated in the vicinity of the ligand-binding pockets. Binding of Pd(2,2‧-bipyridine) at the allosteric site enabled the active conformations of the glutamate receptors to be stabilized. Using this approach, we were able to activate selectively a mutant glutamate receptor in live neurons, which initiated a subsequent signal-transduction pathway.

  20. Classroom Behaviour Management Strategies in Response to Problematic Behaviours of Primary School Children with Special Educational Needs: Views of Special Educational Needs Coordinators

    Science.gov (United States)

    Nye, Elizabeth; Gardner, Frances; Hansford, Lorraine; Edwards, Vanessa; Hayes, Rachel; Ford, Tamsin

    2016-01-01

    Children identified with special educational needs (SEN) and behavioural difficulties present extra challenges to educators and require additional supports in school. This paper presents views from special educational needs coordinators (SENCos) on various strategies used by educators to support children identified with SEN and problematic…

  1. Classroom Behaviour Management Strategies in Response to Problematic Behaviours of Primary School Children with Special Educational Needs: Views of Special Educational Needs Coordinators

    Science.gov (United States)

    Nye, Elizabeth; Gardner, Frances; Hansford, Lorraine; Edwards, Vanessa; Hayes, Rachel; Ford, Tamsin

    2016-01-01

    Children identified with special educational needs (SEN) and behavioural difficulties present extra challenges to educators and require additional supports in school. This paper presents views from special educational needs coordinators (SENCos) on various strategies used by educators to support children identified with SEN and problematic…

  2. The Collaborative Coordination of Special Interest Groups on the Telemedicine University Network (RUTE) in Brazil.

    Science.gov (United States)

    de Lima Verde Brito, Thiago Delevidove; Baptista, Roberto Silva; de Lima Lopes, Paulo Roberto; Haddad, Ana Estela; Messina, Luiz Ary; Torres Pisa, Ivan

    2015-01-01

    In Brazil the Telemedicine University Network (Rede Universitária de Telemedicina RUTE) is an initiative that among others promotes collaboration between university hospitals, universities, and health professionals through information technology infrastructure and special interest groups (SIGs) support. This paper presents results of analyses on collaboration during implementation and coordination activities of RUTE SIGs. This study is based on descriptive statistics and data visualization previously collected by RUTE national coordination relative to the status in July 2014. The analysis through collaboration graph identified the strongest collaboration RUTE units. The graph also highlights the collaborative relationship of RUTE units in form of communities, the most collaborative with each other in a communion in the same SIGs, and the less the collaborative units in the network. It should be stated that the most active units are also the oldest in the community.

  3. Care coordination impacts on access to care for children with special health care needs enrolled in Medicaid and CHIP.

    Science.gov (United States)

    Miller, Kipyn

    2014-05-01

    Children with special health care needs (CSHCN) often require services from multiple health care providers. This study's objective is to evaluate whether CSHCN, enrolled in Medicaid or the Children's Health Insurance Program (CHIP) and receiving care coordination services, experience improved access to mental and specialty health care services. Using data from the 2009-2010 National Survey of Children with Special Health Care Needs, two separate outcomes are used to evaluate children's access to care: receipt of needed mental and specialty care and timely access to services. Using propensity score matching, CSHCN propensity for receiving care coordination services is derived and an assessment is made of care coordination's impact on the receipt of health care and whether care is delayed. Results demonstrate that care coordination is positively associated with whether a child receives the mental and specialty care that they need, regardless of whether or not that coordination is perceived to be adequate by parents. However, receiving care coordination services that parents perceive to be adequate has a larger impact on the timeliness in which care is received. This study indicates that care coordination is associated with an increased ability for CSHCN to access needed mental and specialty care. States should consider offering care coordination services that support provider communication and fulfill families' coordination needs to the CSHCN enrolled in their Medicaid and CHIP programs.

  4. Four-Node Generalized Conforming Membrane Elements with Drilling DOFs Using Quadrilateral Area Coordinate Methods

    Directory of Open Access Journals (Sweden)

    Xiao-Ming Chen

    2015-01-01

    Full Text Available Two 4-node generalized conforming quadrilateral membrane elements with drilling DOF, named QAC4θ and QAC4θM, were successfully developed. Two kinds of quadrilateral area coordinates are used together in the assumed displacement fields of the new elements, so that the related formulations are quite straightforward and will keep the order of the Cartesian coordinates unchangeable while the mesh is distorted. The drilling DOF is defined as the additional rigid rotation at the element nodes to avoid improper constraint. Both elements can pass the strict patch test and exhibit better performance than other similar models. In particular, they are both free of trapezoidal locking in MacNeal’s beam test and insensitive to various mesh distortions.

  5. Coordination-driven in situ self-assembly strategy for the preparation of metal-organic framework hybrid membranes.

    Science.gov (United States)

    Zhang, Rong; Ji, Shulan; Wang, Naixin; Wang, Lin; Zhang, Guojun; Li, Jian-Rong

    2014-09-08

    Metal-organic frameworks (MOFs) have emerged as porous solids of a superior type for the fabrication of membranes. However, it is still challenging to prepare a uniformly dispersed robust MOF hybrid membrane. Herein, we propose a simple and powerful strategy, namely, coordination-driven in situ self-assembly, for the fabrication of MOF hybrid membranes. On the basis of the coordination interactions between metal ions and ligands and/or the functional groups of the organic polymer, this method was confirmed to be feasible for the production of a stable membrane with greatly improved MOF-particle dispersion in and compatibility with the polymer, thus providing outstanding separation ability. As an experimental proof of concept, a high-quality ZIF-8/PSS membrane was fabricated that showed excellent performance in the nanofiltration and separation of dyes from water.

  6. Mandatory Accreditation for Special Educational Needs Co-Ordinators: Biopolitics, Neoliberal Managerialism and the Deleuzo-Guattarian "War Machine"

    Science.gov (United States)

    Done, Elizabeth J.; Murphy, Mike; Knowler, Helen

    2015-01-01

    Recent changes to policy directives now require newly appointed Special Educational Needs Coordinators (SENCOs) in UK mainstream schools to be qualified teachers. Training and accreditation through a nationally approved postgraduate award is now mandatory. Concepts drawn from poststructuralist biopolitics and critiques of neoliberal educational…

  7. Preface: Special Topic on Coarse Graining of Macromolecules, Biopolymers, and Membranes.

    Science.gov (United States)

    Holm, Christian; Gompper, Gerhard; Dill, Ken A

    2015-12-28

    This special issue highlights new developments in theory and coarse-graining in biological and synthetic macromolecules and membranes. Such approaches give unique insights into the principles and design of the structures, dynamics, and assembly processes of these complex fluids and soft materials, where the length and time scales are often prohibitively long for fully atomistic modeling.

  8. Preface: Special Topic on Coarse Graining of Macromolecules, Biopolymers, and Membranes

    Energy Technology Data Exchange (ETDEWEB)

    Holm, Christian [Institut für Computerphysik, Universität Stuttgart, Allmandring 3, 70569 Stuttgart (Germany); Gompper, Gerhard [Theoretical Soft Matter and Biophysics, Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, 52428 Jülich (Germany); Dill, Ken A. [Department of Chemistry, Stony Brook University, Stony Brook, New York 11794 (United States)

    2015-12-28

    This special issue highlights new developments in theory and coarse-graining in biological and synthetic macromolecules and membranes. Such approaches give unique insights into the principles and design of the structures, dynamics, and assembly processes of these complex fluids and soft materials, where the length and time scales are often prohibitively long for fully atomistic modeling.

  9. Selective separation of oil and water with special wettability mesh membranes

    KAUST Repository

    Liu, Defei

    2017-02-24

    Due to the different interfacial effects of oil and water, utilizing the special wettability of solid surfaces to design an oil and water separation process has been demonstrated to be an effective approach for oil/water separation. In this report, a simple process has been developed to fabricate special surface wettability mesh membranes. The carbon nanoparticles with diameters of 10 nm were first coated onto the surface of steel wires based on a candle soot coating process. These templates of carbon nanoparticles were then coated with a more stable layer of silica (SiO2) particles via a facile chemical vapor deposition route. After being modified by two separate methods, a superhydrophobic/superoleophilic membrane was obtained by the use of 1H,1H,2H,2H-perfluorooctyltrichlorosilane (PFOTS) and a oleophobic/superhydrophilic membrane was obtained by using poly(diallyldimethylammonium-perfluorooctanoate) (PDDA–PFO). Separation experiments show that these superhydrophobic/superoleophilic or oleophobic/superhydrophilic mesh membranes can be used to selectively separate oil/water with a high flux of more than 930 L m−2 h−1 and a collecting efficiency of over 97%. Furthermore, the repetitions of the separation experiments demonstrate that these superhydrophobic/superoleophilic or oleophobic/superhydrophilic mesh membranes are durable, stable and reusable, making them encouraging candidates for practical oil-polluted water treatment.

  10. Implementing a care coordination program for children with special healthcare needs: partnering with families and providers.

    Science.gov (United States)

    Taylor, April; Lizzi, Michele; Marx, Alison; Chilkatowsky, Maryann; Trachtenberg, Symme W; Ogle, Sue

    2013-01-01

    Care coordination has been a key theme in national forums on healthcare quality, design, and improvement. This article describes the characteristics of a care coordination program aimed at supporting families in building care coordination competencies and providers in the coordination of care across multiple specialties. The program included implementation of a Care Coordination Counselor (CC Counselor) and several supporting tools-Care Binders, Complex Scheduling, Community Resources for Families Database, and a Care Coordination Network. Patients were referred by a healthcare provider to receive services from the CC Counselor or to receive a Care Binder organizational tool. To assess the impact of the counselor role, we compared patient experience survey results from patients receiving CC Counselor services to those receiving only the Care Binder. Our analysis found that patients supported by the CC Counselor reported greater agreement with accessing care coordination resources and identifying a key point person for coordination. Seventy-five percent of CC Counselor patients have graduated from the program. Our findings suggest that implementation of a CC Counselor role and supporting tools offers an integrative way to connect patients, families, and providers with services and resources to support coordinated, continuous care.

  11. Design of specially adapted reactive coordinates to economically compute potential and kinetic energy operators including geometry relaxation.

    Science.gov (United States)

    Thallmair, Sebastian; Roos, Matthias K; de Vivie-Riedle, Regina

    2016-06-21

    Quantum dynamics simulations require prior knowledge of the potential energy surface as well as the kinetic energy operator. Typically, they are evaluated in a low-dimensional subspace of the full configuration space of the molecule as its dimensionality increases proportional to the number of atoms. This entails the challenge to find the most suitable subspace. We present an approach to design specially adapted reactive coordinates spanning this subspace. In addition to the essential geometric changes, these coordinates take into account the relaxation of the non-reactive coordinates without the necessity of performing geometry optimizations at each grid point. The method is demonstrated for an ultrafast photoinduced bond cleavage in a commonly used organic precursor for the generation of electrophiles. The potential energy surfaces for the reaction as well as the Wilson G-matrix as part of the kinetic energy operator are shown for a complex chemical reaction, both including the relaxation of the non-reactive coordinates on equal footing. A microscopic interpretation of the shape of the G-matrix elements allows to analyze the impact of the non-reactive coordinates on the kinetic energy operator. Additionally, we compare quantum dynamics simulations with and without the relaxation of the non-reactive coordinates included in the kinetic energy operator to demonstrate its influence.

  12. Design of specially adapted reactive coordinates to economically compute potential and kinetic energy operators including geometry relaxation

    Science.gov (United States)

    Thallmair, Sebastian; Roos, Matthias K.; de Vivie-Riedle, Regina

    2016-06-01

    Quantum dynamics simulations require prior knowledge of the potential energy surface as well as the kinetic energy operator. Typically, they are evaluated in a low-dimensional subspace of the full configuration space of the molecule as its dimensionality increases proportional to the number of atoms. This entails the challenge to find the most suitable subspace. We present an approach to design specially adapted reactive coordinates spanning this subspace. In addition to the essential geometric changes, these coordinates take into account the relaxation of the non-reactive coordinates without the necessity of performing geometry optimizations at each grid point. The method is demonstrated for an ultrafast photoinduced bond cleavage in a commonly used organic precursor for the generation of electrophiles. The potential energy surfaces for the reaction as well as the Wilson G-matrix as part of the kinetic energy operator are shown for a complex chemical reaction, both including the relaxation of the non-reactive coordinates on equal footing. A microscopic interpretation of the shape of the G-matrix elements allows to analyze the impact of the non-reactive coordinates on the kinetic energy operator. Additionally, we compare quantum dynamics simulations with and without the relaxation of the non-reactive coordinates included in the kinetic energy operator to demonstrate its influence.

  13. Membrane coordination of receptors and channels mediating the inhibition of neuronal ion currents by ADP.

    Science.gov (United States)

    Gafar, Hend; Dominguez Rodriguez, Manuel; Chandaka, Giri K; Salzer, Isabella; Boehm, Stefan; Schicker, Klaus

    2016-09-01

    ADP and other nucleotides control ion currents in the nervous system via various P2Y receptors. In this respect, Cav2 and Kv7 channels have been investigated most frequently. The fine tuning of neuronal ion channel gating via G protein coupled receptors frequently relies on the formation of higher order protein complexes that are organized by scaffolding proteins and harbor receptors and channels together with interposed signaling components. However, ion channel complexes containing P2Y receptors have not been described. Therefore, the regulation of Cav2.2 and Kv7.2/7.3 channels via P2Y1 and P2Y12 receptors and the coordination of these ion channels and receptors in the plasma membranes of tsA 201 cells have been investigated here. ADP inhibited currents through Cav2.2 channels via both P2Y1 and P2Y12 receptors with phospholipase C and pertussis toxin-sensitive G proteins being involved, respectively. The nucleotide controlled the gating of Kv7 channels only via P2Y1 and phospholipase C. In fluorescence energy transfer assays using conventional as well as total internal reflection (TIRF) microscopy, both P2Y1 and P2Y12 receptors were found juxtaposed to Cav2.2 channels, but only P2Y1, and not P2Y12, was in close proximity to Kv7 channels. Using fluorescence recovery after photobleaching in TIRF microscopy, evidence for a physical interaction was obtained for the pair P2Y12/Cav2.2, but not for any other receptor/channel combination. These results reveal a membrane juxtaposition of P2Y receptors and ion channels in parallel with the control of neuronal ion currents by ADP. This juxtaposition may even result in apparent physical interactions between receptors and channels.

  14. Coordination kinetics of different metal ions with the amidoximated polyacrylonitrile nanofibrous membranes and catalytic behaviors of their complexes

    Energy Technology Data Exchange (ETDEWEB)

    Li, Fu; Dong, Yong Chun; Kang, Wei Min; Cheng, Bowen; Qu, Xiang; Cui, Guixin [School of Textiles, Tianjin Polytechnic University, Tianjin (China)

    2016-12-15

    Two transition metal ions (Fe{sup 3+} and Cu{sup 2+}) and a rare earth metal ion (Ce{sup 3+}) were selected to coordinate with amidoximated polyacrylonitrile (PAN) nanofibrous membrane for preparing three metal modified PAN nanofibrous membrane complexes (M-AO-n-PANs, M = Fe, Cu, or Ce) as the heterogeneous Fenton catalysts for the dye degradation in water under visible irradiation. The coordination kinetics of three metal ions with modified PAN nanofibrous membranes was studied and the catalytic properties of the resulting complexes were also compared. The results indicated that increasing metal ion concentrations in solution or higher coordination temperature led to a significant increase in metal content, particularly in Fe and Cu contents of the complexes. Their coordination process could be described using Langmuir isotherm and pseudo-second-order kinetic equations. Moreover, Fe-AO-n-PAN had the best photocatalytic efficiency for the dye degradation in acidic medium, but a lower photocatalytic activity than Cu-AO-n-PAN in alkali medium.

  15. Accelerating potential of mean force calculations for lipid membrane permeation: System size, reaction coordinate, solute-solute distance, and cutoffs

    Science.gov (United States)

    Nitschke, Naomi; Atkovska, Kalina; Hub, Jochen S.

    2016-09-01

    Molecular dynamics simulations are capable of predicting the permeability of lipid membranes for drug-like solutes, but the calculations have remained prohibitively expensive for high-throughput studies. Here, we analyze simple measures for accelerating potential of mean force (PMF) calculations of membrane permeation, namely, (i) using smaller simulation systems, (ii) simulating multiple solutes per system, and (iii) using shorter cutoffs for the Lennard-Jones interactions. We find that PMFs for membrane permeation are remarkably robust against alterations of such parameters, suggesting that accurate PMF calculations are possible at strongly reduced computational cost. In addition, we evaluated the influence of the definition of the membrane center of mass (COM), used to define the transmembrane reaction coordinate. Membrane-COM definitions based on all lipid atoms lead to artifacts due to undulations and, consequently, to PMFs dependent on membrane size. In contrast, COM definitions based on a cylinder around the solute lead to size-independent PMFs, down to systems of only 16 lipids per monolayer. In summary, compared to popular setups that simulate a single solute in a membrane of 128 lipids with a Lennard-Jones cutoff of 1.2 nm, the measures applied here yield a speedup in sampling by factor of ˜40, without reducing the accuracy of the calculated PMF.

  16. Rupturing the hemi-fission intermediate in membrane fission under tension: Reaction coordinates, kinetic pathways, and free-energy barriers.

    Science.gov (United States)

    Zhang, Guojie; Müller, Marcus

    2017-08-14

    Membrane fission is a fundamental process in cells, involved inter alia in endocytosis, intracellular trafficking, and virus infection. Its underlying molecular mechanism, however, is only incompletely understood. Recently, experiments and computer simulation studies have revealed that dynamin-mediated membrane fission is a two-step process that proceeds via a metastable hemi-fission intermediate (or wormlike micelle) formed by dynamin's constriction. Importantly, this hemi-fission intermediate is remarkably metastable, i.e., its subsequent rupture that completes the fission process does not occur spontaneously but requires additional, external effects, e.g., dynamin's (unknown) conformational changes or membrane tension. Using simulations of a coarse-grained, implicit-solvent model of lipid membranes, we investigate the molecular mechanism of rupturing the hemi-fission intermediate, such as its pathway, the concomitant transition states, and barriers, as well as the role of membrane tension. The membrane tension is controlled by the chemical potential of the lipids, and the free-energy landscape as a function of two reaction coordinates is obtained by grand canonical Wang-Landau sampling. Our results show that, in the course of rupturing, the hemi-fission intermediate undergoes a "thinning → local pinching → rupture/fission" pathway, with a bottle-neck-shaped cylindrical micelle as a transition state. Although an increase of membrane tension facilitates the fission process by reducing the corresponding free-energy barrier, for biologically relevant tensions, the free-energy barriers still significantly exceed the thermal energy scale kBT.

  17. [Development and evaluation of a motor coordination training for children in special-needs classes].

    Science.gov (United States)

    Rothlisberger, Marianne; Michel, Eva

    2009-01-01

    Previous research showed that children in classes with reduced curriculum ("ready for school classes") perform systematically poorer in short-term memory, attention control and motor coordination skills than children in regular classes. Based on these results, a training to improve children's planning, sequencing, and executive control of motor actions was developed. It includes body coordination, (bi-) manual coordination, rhythm and balance. The tasks stress flexibility of action, interference control and focused attention. Training sessions proceed from easy to complex, from action accuracy to speed, and from teacher guidance to children's self monitoring. Over the course of 3 weeks, 53 children were trained daily for 20 mins. In pre- and posttests, motor coordination was assessed with the M-ABC; focused attention, short-term memory performance, and self-concept was tested with paper-pencil and computerized tasks. Half of the children were trained between pre- and posttest, the other half received the training after posttest. Results revealed no global training effects; however, children in the training condition caught up during training in specific cognitive and motor tasks, and trained children showed a more optimistic self-concept. Training effects were pronounced for children with balance problems. The findings are discussed in terms of reasons for the weak training effects, and potential improvements of the training.

  18. An innovative Oklahoma program to coordinate interdisciplinary and interagency services for children with special healthcare needs at a county level.

    Science.gov (United States)

    Wolraich, Mark; Lockhart, Jennifer; Worley, Louis

    2013-03-01

    Children and youth with special health care needs (CYSHCN) and their families often require multiple services from multiple providers in order to meet their needs. The Sooner SUCCESS (State Unified Children's Comprehensive Exemplary Services for Special Needs), was developed based on a complex adaptive systems approach allowing local coalitions to address their unique needs. Sooner SUCCESS provides support to families and service providers at the community level including a broad range of supports from simply helping a family identify and access a service that already exists to innovatively marshaling generic resources to meet a unique need. The program uses these family support activities coupled with the Community Needs Assessment to identify local service needs encouraging community capacity building by coordinating the efforts of the health, mental health, social and education systems to identify service gaps and develop community-based strategies to fill those gaps.

  19. United States Gulf Coast geopressured geothermal program. Special projects research and coordination assistance. Final report, 1 December 1978-30 October 1980

    Energy Technology Data Exchange (ETDEWEB)

    Dorfman, M.H.; Morton, R.A.

    1981-06-01

    Work for the period, December 1, 1978 through October 31, 1980, is documented. The following activities are covered: project technical coordination assistance and liaison; technical assistance for review and evaluation of proposals and contract results; technical assistance for geopressured-geothermal test wells; technical assistance, coordination, and planning of surface utilization program; legal research; and special projects. (MHR)

  20. Physical Education, Resources and Training: The Perspective of Special Educational Needs Coordinators Working in Secondary Schools in North-West England

    Science.gov (United States)

    Maher, Anthony; Macbeth, Jessica

    2014-01-01

    The Code of Practice of the Department for Education (1994) establishes the role of special educational needs coordinator (SENCO) to help facilitate the inclusion of pupils with special educational needs (SEN) in mainstream schools. SENCOs, thus, should form an integral part of the culture of all departments, including physical education (PE).…

  1. To Ingest or Rest? Specialized Roles of Lateral Hypothalamic Area Neurons in Coordinating Energy Balance

    Directory of Open Access Journals (Sweden)

    Juliette A. Brown

    2015-02-01

    Full Text Available Survival depends on an organism’s ability to sense nutrient status and accordingly regulate intake and energy expenditure behaviors. Uncoupling of energy sensing and behavior, however, underlies energy balance disorders such as anorexia or obesity. The hypothalamus regulates energy balance, and in particular the lateral hypothalamic area (LHA is poised to coordinate peripheral cues of energy status and behaviors that impact weight, such as drinking, locomotor behavior, arousal/sleep and autonomic output. There are several populations of LHA neurons that are defined by their neuropeptide content and contribute to energy balance. LHA neurons that express the neuropeptides melanin-concentrating hormone (MCH or orexins/hypocretins (OX are best characterized and these neurons play important roles in regulating ingestion, arousal, locomotor behavior and autonomic function via distinct neuronal circuits. Recently, another population of LHA neurons containing the neuropeptide Neurotensin (Nts has been implicated in coordinating anorectic stimuli and behavior to regulate hydration and energy balance. Understanding the specific roles of MCH, OX and Nts neurons in harmonizing energy sensing and behavior thus has the potential to inform pharmacological strategies to modify behaviors and treat energy balance disorders.

  2. Towards Acid-Tolerated Ethanol Dehydration: Chitosan-Based Mixed Matrix Membranes Containing Cyano-Bridged Coordination Polymer Nanoparticles.

    Science.gov (United States)

    Wu, C-W; Kang, Chao-Hsiang; Lin, Yi-Feng; Tung, Kuo-Lun; Deng, Yu-Heng; Ahamad, Tansir; Alshehri, Saad M; Suzuki, Norihiro; Yamauchi, Yusuke

    2016-04-01

    Prussian blue (PB) nanoparticles, one of many cyano-bridged coordination polymers, are successfully incorporated into chitosan (CS) polymer to prepare PB/CS mixed matrix membranes (MMMs). The PB nanoparticles are uniformly distributed in the MMMs without the collapse of the original PB structure. As-prepared PB/CS MMMs are used for ethanol dehydration at 25 °C in the pervaporation process. The effect of loading PB in CS matrix on pervaporation performance is carefully investigated. The PB/CS membrane with 30 wt% PB loading shows the best performance with a permeate flux of 614 g. m-2 . h-1 and a separation factor of 1472. The pervaporation using our PB/CS membranes exhibits outstanding performance in comparison with the previously reported CS-based membranes and MMMs. Furthermore, the addition of PB allows PB/CS MMMs to be tolerant of acidic environment. The present work demonstrates good pervaporation performance of PB/CS MMMs for the separation of an ethanol/water (90:10 in wt%) solution. Our new system provides an opportunity for dehydration of bioethanol in the future.

  3. Maxwell's equations as a special case of deformation of a solid lattice in Euler's coordinates

    CERN Document Server

    Gremaud, G

    2016-01-01

    It is shown that the set of equations known as Maxwell's equations perfectly describe two very different systems: (1) the usual electromagnetic phenomena in vacuum or in the matter and (2) the deformation of isotropic solid lattices, containing topological defects as dislocations and disclinations, in the case of constant and homogenous expansion. The analogy between these two physical systems is complete, as it is not restricted to one of the two Maxwell's equation couples in the vacuum, but generalized to the two equation couples as well as to the diverse phenomena of dielectric polarization and magnetization of matter, just as to the electrical charges and the electrical currents. The eulerian approach of the solid lattice developed here includes Maxwell's equations as a special case, since it stems from a tensor theory, which is reduced to a vector one by contraction on the tensor indices. Considering the tensor aspect of the eulerian solid lattice deformation theory, the analogy can be extended to other ...

  4. Planning, Coordinating, and Managing Off-Site Storage is an Area of Increasing, Professional Responsibility for Special Collections Departments

    Directory of Open Access Journals (Sweden)

    Melissa Goertzen

    2016-03-01

    two locations instead of one. Also, the integration of new workflows required additional oversight to ensure adequate control at all points of process. Static staffing levels and increased levels of responsibility impacted preservation and conservation activities as well. A central concern was the handling of materials by facility staff not trained as special collections professionals. In regard to the facilities themselves, a general concern was that commercial warehouses do not always provide the kind of environmental control systems recommended for storage of special collections materials. Of the total sample group, 12 participants (19% said their institution does not use off-site storage for special collections. When asked if this may occur in the future, four directors (33% said they anticipate off-site storage use within the next five years. Lack of space was listed as the primary motivation. Conclusion – Study findings provide evidence for what was previously known anecdotally: planning, coordinating, and managing off-site storage is a significant professional responsibility that will only grow in the future. As primary resources are integrated into research, teaching, and learning activities, the acquisition of special collections materials will continue to grow. Discussions regarding off-site storage workflows and strategic planning will continue as professionals seek compromises that meet the unique needs of acquisition, preservation, and public service.

  5. Evidence of hemispheric specialization in marmosets (Callithrix penicillata using tympanic membrane thermometry

    Directory of Open Access Journals (Sweden)

    C. Tomaz

    2003-07-01

    Full Text Available Recent studies have employed tympanic thermometry to assess lateralization of cognitive and emotional functions in primates. However, no studies using this technique have investigated the possibility of hemispheric specialization in New World monkeys. Therefore, the aim of the present study was to investigate tympanic membrane (TM temperature asymmetries and their possible correlation with stress responses in marmosets (Callithrix penicillata. Infrared TM thermometry was completed bilaterally in 24 animals (14 males and 10 females during a stressful situation of capture and restraint. There were no significant differences between gender. A significant negative correlation was observed between TM temperature of the right ear and the number of captures (r = -0.633; P<0.001. Subjects with a more frequent previous history of captures (5 to 9 captures; N = 11 showed lower TM temperature when compared to those with fewer previous captures (1 to 4 captures; N = 13. No differences were observed for the left TM temperature. These results suggest that under intense emotional challenge (capture and restraint there is a stronger activation of the neural structures situated in the right brain hemisphere. Taken together, the data reveal for the first time evidence of hemispheric specialization in emotional physiological processing in a New World monkey.

  6. Copper Coordination to the Membrane Bound Form of α-Synuclein

    OpenAIRE

    Dudzik, Christopher G.; Walter, Eric D; Abrams, Benjamin S.; Jurica, Melissa S.; Millhauser, Glenn L.

    2012-01-01

    Aggregation of the 140 amino acid protein α-synuclein (α-syn) is linked to the development of Parkinson’s disease (PD). α-Syn is a copper binding protein with potential function as a regulator of metal dependent redox activity. Epidemiological studies suggest that human exposure to excess copper increases the incidence of PD. α-Syn exists in both solution and membrane bound forms. Previous work evaluated the Cu2+ uptake for α-syn in solution and identified Met1 Asp2 and His50 as primary contr...

  7. [Wisconsin Administrative Practice Scale: Special Education. A Survey of Selected Administrative Practices Used in the Coordination of Diagnostic Units for Handicapped Children. Test and Manual.].

    Science.gov (United States)

    Lietz, Jeremy Jon

    The Wisconsin Administrative Practice Scale: Special Education (WAPS) is a self-administering survey instrument designed to measure implementation of 162 selected administrative practices and policies used to coordinate diagnostic units for handicapped children. One hundred thirty-five items are grouped into seven subscales each consisting of…

  8. An Exploratory Study of Special Educational Needs Co-Ordinators' Knowledge and Experience of Working with Children Who Have Sustained a Brain Injury

    Science.gov (United States)

    Howe, Julia; Ball, Heather

    2017-01-01

    This research aimed to measure Special Educational Needs Co-ordinators' knowledge of the educational implications of acquired brain injury in children and young people and whether experience of working with pupils with a brain injury or additional training impacts upon this knowledge. Data was collected within one local authority in England using…

  9. [Coupling coordination evaluation method between eco-environment quality and economic development level in contiguous special poverty-stricken areas of China].

    Science.gov (United States)

    Wang, Yan-hui; Li, Jing-yi

    2015-05-01

    It is one of the important strategies in the new period of national poverty alleviation and development to maintain the basic balance between the ecological environment and economic development, and to promote the coordinated sustainable development of economy and ecological environment. Taking six contiguous special poverty-stricken areas as the study areas, a coupling coordination evaluation method between eco-environment quality and economic development level in contiguous special poverty-stricken areas was explored in this paper. The region' s ecological poverty index system was proposed based on the natural attribute of ecological environment, and the ecological environment quality evaluation method was built up by using AHP weighting method, followed by the design of the coupling coordination evaluation method between the ecological environment indices and the county economic poverty comprehensive indices. The coupling coordination degrees were calculated and their spatial representation differentiations were analyzed respectively at district, province, city, and county scales. Results showed that approximately half of the counties in the study areas achieved the harmoniously coordinated development. However, the ecological environmental quality and the economic development in most counties could not be synchronized, where mountains, rivers and other geographic features existed roughly as a dividing line of the coordinated development types. The phenomena of dislocation between the ecological environment and economic development in state-level poor counties were more serious than those of local poor counties.

  10. Sleep Problems as Consequence, Contributor, and Comorbidity: Introduction to the Special Issue on Sleep, Published in Coordination With Special Issues in Clinical Practice in Pediatric Psychology and Journal of Developmental and Behavioral Pediatrics.

    Science.gov (United States)

    Beebe, Dean W

    2016-07-01

    Despite long-standing public and scientific interest in the phenomenon of sleep, the current decade has shown tremendous growth in our understanding of the sleep of children who have medical or developmental conditions. To accommodate, promote, and guide that growth, Journal of Pediatric Psychology, Clinical Practice in Pediatric Psychology, and Journal of Developmental and Behavioral Pediatrics have published coordinated special issues, encompassing >30 relevant articles. This article introduces the special issue in Journal of Pediatric Psychology, highlighting papers that illustrate how sleep problems are not only commonly comorbid with childhood medical and developmental conditions; they are also likely caused by and contribute to these conditions. In doing so, these coordinated special issues guide clinical care and reveal opportunities for future research. © The Author 2016. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Coordination of Pancreatic HCO3- Secretion by Protein-Protein Interaction between Membrane Transporters

    Directory of Open Access Journals (Sweden)

    Lee MG

    2001-07-01

    Full Text Available Increasing evidence suggests that protein-protein interaction is essential in many biological processes including epithelial transport. In this report, we discuss the significance of protein interactions to HCO(3(- secretion in pancreatic duct cells. In pancreatic ducts HCO(3(- secretion is mediated by cystic fibrosis transmembrane conductance regulator (CFTR activated luminal Cl(-/HCO(3(- exchange activity and HCO(3(- absorption is achieved by Na(+-dependent mechanisms including Na(+/H(+ exchanger 3 (NHE3. We found biochemical and functional association between CFTR and NHE3. In addition, protein binding through PDZ modules is needed for this regulatory interaction. CFTR affected NHE3 activities in two ways. Acutely, CFTR augmented the cAMP-dependent inhibition of NHE3. In a chronic mechanism, CFTR increases the luminal expression of Na(+/H(+ exchange in pancreatic duct cells. These findings reveal that protein complexes in the plasma membrane of pancreatic duct cells are highly organized for efficient HCO(3(- secretion.

  12. The impact of development o f the special coordination abilities on the general skill ability for table tennis juniors under 12 years old

    Directory of Open Access Journals (Sweden)

    Shawkat Gaber Radwan

    2014-06-01

    Full Text Available Indicates each of Muhama d Allawi (2002, Essam Abdul Khaliq (2003, and Walf Droge (2002 that the coordination abilities are closely related to the development of technical motor skills, and that pra ctitioner athletic activity which determines the quality of this abilities should be developed, where the player can not master the technical skills in the special activity in case lack of special coordination abilities for this activity. Both Manf red Must er (1986, Jürgen Schmicker (2000, Wolfgang and others (2000 and Wohlgefahrt, Karlheinz (2004 refers that the special coordination abilities for table tennis include each of: 1 - The motor adaptation and adjustment ability, 2 - The ability to differentiat e , 3 - reaction speed ability, 4 - orientation ability, 5 - balance ability, 6 - coupling ability, 7 - The ability to sense the rhythm. The aim of this study is design training program to development the special coordination abilities of table tennis and identi fies the impact of this program on the general skill ability for table tennis juniors under 12 years old. The researcher used the experimental method into two groups one experimental and the other control group the strength of each of them is 8 of table te nnis juniors in Ismailia city in Egypt. The duration of the program is three months, three training units a week the duration of each training unit is 90 minutes. The most important results of this study was the training program led to improvement the spec ial coordination abilities of table tennis for the experimental group, which led to high level of the general skill ability in table tennis for the experimental group more than the control group .

  13. Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure.

    Directory of Open Access Journals (Sweden)

    Edward C Goodwin

    Full Text Available DNAJB12 and DNAJB14 are transmembrane proteins in the endoplasmic reticulum (ER that serve as co-chaperones for Hsc70/Hsp70 heat shock proteins. We demonstrate that over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous structures within cell nuclei, which we designate DJANGOS for DNAJ-associated nuclear globular structures. DJANGOS contain DNAJB12, DNAJB14, Hsc70 and markers of the ER lumen and ER and nuclear membranes. Strikingly, they are evenly distributed underneath the nuclear envelope and are of uniform size in any one nucleus. DJANGOS are composed primarily of single-walled membrane tubes and sheets that connect to the nuclear envelope via a unique configuration of membranes, in which the nuclear pore complex appears anchored exclusively to the outer nuclear membrane, allowing both the inner and outer nuclear membranes to flow past the circumference of the nuclear pore complex into the nucleus. DJANGOS break down rapidly during cell division and reform synchronously in the daughter cell nuclei, demonstrating that they are dynamic structures that undergo coordinate formation and dissolution. Genetic studies showed that the chaperone activity of DNAJ/Hsc70 is required for the formation of DJANGOS. Further analysis of these structures will provide insight into nuclear pore formation and function, activities of molecular chaperones, and mechanisms that maintain membrane identity.

  14. Membraner

    DEFF Research Database (Denmark)

    Bach, Finn

    2009-01-01

    Notatet giver en kort introduktion til den statiske virkemåde af membraner og membrankonstruktioner......Notatet giver en kort introduktion til den statiske virkemåde af membraner og membrankonstruktioner...

  15. Lipid rafts in epithelial brush borders: atypical membrane microdomains with specialized functions

    DEFF Research Database (Denmark)

    Danielsen, E Michael; Hansen, Gert H

    2003-01-01

    of the apical surface sterically accessible for membrane fusion/budding events. Many of these invaginations appear as pleiomorphic, deep apical tubules that extend up to 0.5-1 microm into the underlying terminal web region. Their sensitivity to methyl-beta-cyclodextrin suggests them to contain cholesterol...

  16. Integrating complex functions: coordination of nuclear pore complex assembly and membrane expansion of the nuclear envelope requires a family of integral membrane proteins.

    Science.gov (United States)

    Schneiter, Roger; Cole, Charles N

    2010-01-01

    The nuclear envelope harbors numerous large proteinaceous channels, the nuclear pore complexes (NPCs), through which macromolecular exchange between the cytosol and the nucleoplasm occurs. This double-membrane nuclear envelope is continuous with the endoplasmic reticulum and thus functionally connected to such diverse processes as vesicular transport, protein maturation and lipid synthesis. Recent results obtained from studies in Saccharomyces cerevisiae indicate that assembly of the nuclear pore complex is functionally dependent upon maintenance of lipid homeostasis of the ER membrane. Previous work from one of our laboratories has revealed that an integral membrane protein Apq12 is important for the assembly of functional nuclear pores. Cells lacking APQ12 are viable but cannot grow at low temperatures, have aberrant NPCs and a defect in mRNA export. Remarkably, these defects in NPC assembly can be overcome by supplementing cells with a membrane fluidizing agent, benzyl alcohol, suggesting that Apq12 impacts the flexibility of the nuclear membrane, possibly by adjusting its lipid composition when cells are shifted to a reduced temperature. Our new study now expands these findings and reveals that an essential membrane protein, Brr6, shares at least partially overlapping functions with Apq12 and is also required for assembly of functional NPCs. A third nuclear envelope membrane protein, Brl1, is related to Brr6, and is also required for NPC assembly. Because maintenance of membrane homeostasis is essential for cellular survival, the fact that these three proteins are conserved in fungi that undergo closed mitoses, but are not found in metazoans or plants, may indicate that their functions are performed by proteins unrelated at the primary sequence level to Brr6, Brl1 and Apq12 in cells that disassemble their nuclear envelopes during mitosis.

  17. Amniotic Membrane Transplant with a Special Technique (Motowa's Sandwich Technique) in Mooren's Ulcer.

    Science.gov (United States)

    Al Motowa, Saeed; Al Zobidi, Mohammed

    2015-01-01

    To illustrate amniotic membrane transplant (AMT) with a novel surgical technique ("sandwich technique") for treating patients with malignant Mooren's ulcer. A case report of a patient with bilateral, malignant Mooren's ulcer who had undergone systemic steroid therapy and topical immunosuppresive therapy to stabilize his condition. However, perforation of cornea occurred in one eye. AMT with a new surgical technique ("Motowa's sandwich technique") was performed to treat this case. On the 1(st) day postoperatively, there was no pain, no photophobia, and visual acuity was same as preoperatively. At 4 weeks postoperatively, visual acuity improved in the right eye to 20/160 with pinhole, and there was no fluorescein staining. The right eye was quiet. Amniotic membrane transplant with "Motowa's sandwich technique" resulted in the preservation of the anatomical integrity and progression of disease was halted along with an improved vision. This technique is a novel surgical modality in treating Mooren's ulcer. Further study on a large cohort of patients is required for evidence-based data to verify the outcome of this initial case report.

  18. Flash-and-freeze: coordinating optogenetic stimulation with rapid freezing to visualize membrane dynamics at synapses with millisecond resolution

    Directory of Open Access Journals (Sweden)

    Shigeki Watanabe

    2016-08-01

    Full Text Available Electron microscopy depicts subcellular structures at synapses exquisitely but only captures static images. To visualize membrane dynamics, we have developed a novel technique, called flash-and-freeze, which induces neuronal activity with a flash of light and captures the membrane dynamics by rapid freezing. For characterizing membrane movements during synaptic transmission, a light-sensitive cation channel, channelrhodopsin, is heterologously expressed in mouse hippocampal neurons or in Caenorhabditis elegans motor neurons. A brief pulse of blue light activates channelrhodopsin and induces an action potential, leading to synaptic transmission. Following the light stimulation, neurons are frozen at different time intervals ranging from 10 ms to 20 s. Electron micrographs are then acquired from each time point to visualize the morphological changes. Using this approach, we have characterized a novel form of endocytosis, ultrafast endocytosis, which rapidly removes excess membrane added to the surface during neurotransmission. The flash-and-freeze approach can be adapted to study other cellular phenomena that can be induced by light-sensitive genetic or pharmacological tools.

  19. Flash-and-Freeze: Coordinating Optogenetic Stimulation with Rapid Freezing to Visualize Membrane Dynamics at Synapses with Millisecond Resolution

    Science.gov (United States)

    Watanabe, Shigeki

    2016-01-01

    Electron microscopy depicts subcellular structures at synapses exquisitely but only captures static images. To visualize membrane dynamics, we have developed a novel technique, called flash-and-freeze, which induces neuronal activity with a flash of light and captures the membrane dynamics by rapid freezing. For characterizing membrane movements during synaptic transmission, a light-sensitive cation channel, channelrhodopsin, is heterologously expressed in mouse hippocampal neurons or in Caenorhabditis elegans motor neurons. A brief pulse of blue light activates channelrhodopsin and induces an action potential, leading to synaptic transmission. Following the light stimulation, neurons are frozen at different time intervals ranging from 10 ms to 20 s. Electron micrographs are then acquired from each time point to visualize the morphological changes. Using this approach, we have characterized a novel form of endocytosis, ultrafast endocytosis, which rapidly removes excess membrane added to the surface during neurotransmission. The flash-and-freeze approach can be adapted to study other cellular phenomena that can be induced by light-sensitive genetic or pharmacological tools. PMID:27594835

  20. N-Acyl Homoserine Lactone-Mediated Quorum Sensing with Special Reference to Use of Quorum Quenching Bacteria in Membrane Biofouling Control

    Directory of Open Access Journals (Sweden)

    Harshad Lade

    2014-01-01

    Full Text Available Membrane biofouling remains a severe problem to be addressed in wastewater treatment systems affecting reactor performance and economy. The finding that many wastewater bacteria rely on N-acyl homoserine lactone-mediated quorum sensing to synchronize their activities essential for biofilm formations; the quenching bacterial quorum sensing suggests a promising approach for control of membrane biofouling. A variety of quorum quenching compounds of both synthetic and natural origin have been identified and found effective in inhibition of membrane biofouling with much less environmental impact than traditional antimicrobials. Work over the past few years has demonstrated that enzymatic quorum quenching mechanisms are widely conserved in several prokaryotic organisms and can be utilized as a potent tool for inhibition of membrane biofouling. Such naturally occurring bacterial quorum quenching mechanisms also play important roles in microbe-microbe interactions and have been used to develop sustainable nonantibiotic antifouling strategies. Advances in membrane fabrication and bacteria entrapment techniques have allowed the implication of such quorum quenching bacteria for better design of membrane bioreactor with improved antibiofouling efficacies. In view of this, the present paper is designed to review and discuss the recent developments in control of membrane biofouling with special emphasis on quorum quenching bacteria that are applied in membrane bioreactors.

  1. N-acyl homoserine lactone-mediated quorum sensing with special reference to use of quorum quenching bacteria in membrane biofouling control.

    Science.gov (United States)

    Lade, Harshad; Paul, Diby; Kweon, Ji Hyang

    2014-01-01

    Membrane biofouling remains a severe problem to be addressed in wastewater treatment systems affecting reactor performance and economy. The finding that many wastewater bacteria rely on N-acyl homoserine lactone-mediated quorum sensing to synchronize their activities essential for biofilm formations; the quenching bacterial quorum sensing suggests a promising approach for control of membrane biofouling. A variety of quorum quenching compounds of both synthetic and natural origin have been identified and found effective in inhibition of membrane biofouling with much less environmental impact than traditional antimicrobials. Work over the past few years has demonstrated that enzymatic quorum quenching mechanisms are widely conserved in several prokaryotic organisms and can be utilized as a potent tool for inhibition of membrane biofouling. Such naturally occurring bacterial quorum quenching mechanisms also play important roles in microbe-microbe interactions and have been used to develop sustainable nonantibiotic antifouling strategies. Advances in membrane fabrication and bacteria entrapment techniques have allowed the implication of such quorum quenching bacteria for better design of membrane bioreactor with improved antibiofouling efficacies. In view of this, the present paper is designed to review and discuss the recent developments in control of membrane biofouling with special emphasis on quorum quenching bacteria that are applied in membrane bioreactors.

  2. Membrane transporters for the special amino acid glutamine: Structure/function relationships and relevance to human health.

    Directory of Open Access Journals (Sweden)

    Lorena ePochini

    2014-08-01

    Full Text Available Glutamine together with glucose is essential for body’s homeostasis. It is the most abundant amino acid and is involved in many biosynthetic, regulatory and energy production processes. Several membrane transporters which differ in transport modes, ensure glutamine homeostasis by coordinating its absorption, reabsorption and delivery to tissues. These transporters belong to different protein families, are redundant and ubiquitous. Their classification, originally based on functional properties, has recently been associated with the SLC nomenclature. Function of glutamine transporters is studied in cells over-expressing the transporters or, more recently in proteoliposomes harboring the proteins extracted from animal tissues or over-expressed in microorganisms. The role of the glutamine transporters is linked to their transport modes and coupling with Na+ and H+. Most transporters share specificity for other neutral or cationic amino acids. Na+-dependent co-transporters efficiently accumulate glutamine while antiporters regulate the pools of glutamine and other amino acids. The most acknowledged glutamine transporters belong to the SLC1, 6, 7 and 38 families. The members involved in the homeostasis are the co-transporters B0AT1 and the SNAT members 1, 2, 3, 5 and 7; the antiporters ASCT2, LAT1 and 2. The last two are associated to the ancillary CD98 protein. Some information on regulation of the glutamine transporters exist, which, however, need to be deepened. No information at all is available on structures, besides some homology models obtained using similar bacterial transporters as templates. Some models of rat and human glutamine transporters highlight very similar structures between the orthologues. Moreover the presence of glycosylation and/or phosphorylation sites located at the extracellular or intracellular faces has been predicted. ASCT2 and LAT1 are over-expressed in several cancers, thus representing potential targets for

  3. Membrane transporters for the special amino acid glutamine: Structure/function relationships and relevance to human health.

    Science.gov (United States)

    Pochini, Lorena; Scalise, Mariafrancesca; Galluccio, Michele; Indiveri, Cesare

    2014-08-01

    Glutamine together with glucose is essential for body’s homeostasis. It is the most abundant amino acid and is involved in many biosynthetic, regulatory and energy production processes. Several membrane transporters which differ in transport modes, ensure glutamine homeostasis by coordinating its absorption, reabsorption and delivery to tissues. These transporters belong to different protein families, are redundant and ubiquitous. Their classification, originally based on functional properties, has recently been associated with the SLC nomenclature. Function of glutamine transporters is studied in cells over-expressing the transporters or, more recently in proteoliposomes harboring the proteins extracted from animal tissues or over-expressed in microorganisms. The role of the glutamine transporters is linked to their transport modes and coupling with Na+ and H+. Most transporters share specificity for other neutral or cationic amino acids. Na+-dependent co-transporters efficiently accumulate glutamine while antiporters regulate the pools of glutamine and other amino acids. The most acknowledged glutamine transporters belong to the SLC1, 6, 7 and 38 families. The members involved in the homeostasis are the co-transporters B0AT1 and the SNAT members 1, 2, 3, 5 and 7; the antiporters ASCT2, LAT1 and 2. The last two are associated to the ancillary CD98 protein. Some information on regulation of the glutamine transporters exist, which, however, need to be deepened. No information at all is available on structures, besides some homology models obtained using similar bacterial transporters as templates. Some models of rat and human glutamine transporters highlight very similar structures between the orthologues. Moreover the presence of glycosylation and/or phosphorylation sites located at the extracellular or intracellular faces has been predicted. ASCT2 and LAT1 are over-expressed in several cancers, thus representing potential targets for pharmacological intervention.

  4. 美国国务院“西藏问题特别协调员”的设立及其活动%US Special Coordinator for Tibetan Issues and Their Activities

    Institute of Scientific and Technical Information of China (English)

    韩磊; 薛丹

    2013-01-01

      1997年10月美国国务院与国会议员达成妥协设立“西藏问题特别协调员”一职。《2002年西藏政策法》明确规定了这一职位的职责范围,使其成为国务院中常设的制度化的职位。克莱格等4位协调员在敦促中国政府与达赖喇嘛及其代表接触商谈、关注境外藏人难民事务、提交涉藏事务报告等问题上发挥了关键性作用,美国对西藏事务干预力度明显加强。%Clinton Administration sets up a position-Special Coordinator for Tibetan Issues-in October 1997. Tibetan Policy Act of 2002 has institutionalized the responsibility of Special Coordinator for Tibetan Issues, whose role has been more and more important. The Special Coordinators for Tibetan Issues have been playing crucial role in promoting contact between Chinese Government and DaLai Lama, paying close attention to Tibetan refugee affairs since 1997. US Government intervention in the Chinese inner affairs is reflected in establishing the post of Special Coordinator for Tibetan Issues.

  5. Coordination of storage lipid synthesis and membrane biogenesis: evidence for cross-talk between triacylglycerol metabolism and phosphatidylinositol synthesis.

    Science.gov (United States)

    Gaspar, Maria L; Hofbauer, Harald F; Kohlwein, Sepp D; Henry, Susan A

    2011-01-21

    Despite the importance of triacylglycerols (TAG) and steryl esters (SE) in phospholipid synthesis in cells transitioning from stationary-phase into active growth, there is no direct evidence for their requirement in synthesis of phosphatidylinositol (PI) or other membrane phospholipids in logarithmically growing yeast cells. We report that the dga1Δlro1Δare1Δare2Δ strain, which lacks the ability to synthesize both TAG and SE, is not able to sustain normal growth in the absence of inositol (Ino(-) phenotype) at 37 °C especially when choline is present. Unlike many other strains exhibiting an Ino(-) phenotype, the dga1Δlro1Δare1Δare2Δ strain does not display a defect in INO1 expression. However, the mutant exhibits slow recovery of PI content compared with wild type cells upon reintroduction of inositol into logarithmically growing cultures. The tgl3Δtgl4Δtgl5Δ strain, which is able to synthesize TAG but unable to mobilize it, also exhibits attenuated PI formation under these conditions. However, unlike dga1Δlro1Δare1Δare2Δ, the tgl3Δtgl4Δtgl5Δ strain does not display an Ino(-) phenotype, indicating that failure to mobilize TAG is not fully responsible for the growth defect of the dga1Δlro1Δare1Δare2Δ strain in the absence of inositol. Moreover, synthesis of phospholipids, especially PI, is dramatically reduced in the dga1Δlro1Δare1Δare2Δ strain even when it is grown continuously in the presence of inositol. The mutant also utilizes a greater proportion of newly synthesized PI than wild type for the synthesis of inositol-containing sphingolipids, especially in the absence of inositol. Thus, we conclude that storage lipid synthesis actively influences membrane phospholipid metabolism in logarithmically growing cells.

  6. Ribosomal protein S6 kinase1 coordinates with TOR-Raptor2 to regulate thylakoid membrane biosynthesis in rice.

    Science.gov (United States)

    Sun, Linxiao; Yu, Yonghua; Hu, Weiqin; Min, Qiming; Kang, Huiling; Li, Yilu; Hong, Yue; Wang, Xuemin; Hong, Yueyun

    2016-07-01

    Ribosomal protein S6 kinase (S6K) functions as a key component in the target of rapamycin (TOR) pathway involved in multiple processes in eukaryotes. The role and regulation of TOR-S6K in lipid metabolism remained unknown in plants. Here we provide genetic and pharmacological evidence that TOR-Raptor2-S6K1 is important for thylakoid galactolipid biosynthesis and thylakoid grana modeling in rice (Oryza sativa L.). Genetic suppression of S6K1 caused pale yellow-green leaves, defective thylakoid grana architecture. S6K1 directly interacts with Raptor2, a core component in TOR signaling, and S6K1 activity is regulated by Raptor2 and TOR. Plants with suppressed Raptor2 expression or reduced TOR activity by inhibitors mimicked the S6K1-deficient phenotype. A significant reduction in galactolipid content was found in the s6k1, raptor2 mutant or TOR-inhibited plants, which was accompanied by decreased transcript levels of the set of genes such as lipid phosphate phosphatase α5 (LPPα5), MGDG synthase 1 (MGD1), and DGDG synthase 1 (DGD1) involved in galactolipid synthesis, compared to the control plants. Moreover, loss of LPPα5 exhibited a similar phenotype with pale yellow-green leaves. These results suggest that TOR-Raptor2-S6K1 is important for modulating thylakoid membrane lipid biosynthesis, homeostasis, thus enhancing thylakoid grana architecture and normal photosynthesis ability in rice.

  7. Metric dynamics for membrane transformation through regulated cell proliferation

    OpenAIRE

    Ito, Hiroshi C.

    2016-01-01

    This study develops an equation for describing three-dimensional membrane transformation through proliferation of its component cells regulated by morphogen density distributions on the membrane. The equation is developed in a two-dimensional coordinate system mapped on the membrane, referred to as the membrane coordinates. When the membrane expands, the membrane coordinates expand in the same manner so that the membrane is invariant in the coordinates. In the membrane coordinate system, the ...

  8. Attitudes towards Addressing Medical Absenteeism of Students: A Qualitative Study among Principals and Special Education Needs Coordinators in Dutch Secondary Schools

    Science.gov (United States)

    Feron, Frans; Rots – de Vries, Carin; van de Goor, Ien

    2016-01-01

    Background Reducing school absenteeism benefits the health and educational opportunities of young people. The Dutch intervention Medical Advice for Sick-reported Students (abbreviated as MASS) was developed to address school absenteeism due to sickness reporting, also called medical absenteeism. This study is part of a research project on the effectiveness of MASS and explores factors that influence the implementation and dissemination of the intervention, from schools’ perspectives. The research questions include reasons schools have to implement MASS, their experiences in the implementation of MASS and their views on what is needed to ensure sustainable implementation. Methods A qualitative research method was used. Semi-structured interviews were held with nine principals and eight special education needs coordinators, working in nine secondary schools that apply MASS. Inductive content analysis was carried out. Findings The main reasons for schools to address medical absenteeism were their concerns about students’ well-being and future prospects and their wish to share these concerns with students’ parents. Participants also mentioned the wish to raise the threshold for reporting sick. According to the participants, MASS makes it easier for teachers to enter into conversation with students and their parents about medical absence. MASS prevents damage to the relationship with parents and medical problems being missed. In implementing MASS the main obstacles are teachers’ dialogue about medical absence with students and their parents, teachers’ follow-up of the feedback of the youth health care physicians (YHCPs), and correct registration. The participants were convinced that MASS also improves collaboration with parents regarding the optimization of care for students. Conclusions MASS allows schools to identify students at risk of dropout at an early stage and to optimise guidance of these students. The intervention matches schools’ need to address

  9. Attitudes towards Addressing Medical Absenteeism of Students: A Qualitative Study among Principals and Special Education Needs Coordinators in Dutch Secondary Schools.

    Directory of Open Access Journals (Sweden)

    Yvonne Vanneste

    Full Text Available Reducing school absenteeism benefits the health and educational opportunities of young people. The Dutch intervention Medical Advice for Sick-reported Students (abbreviated as MASS was developed to address school absenteeism due to sickness reporting, also called medical absenteeism. This study is part of a research project on the effectiveness of MASS and explores factors that influence the implementation and dissemination of the intervention, from schools' perspectives. The research questions include reasons schools have to implement MASS, their experiences in the implementation of MASS and their views on what is needed to ensure sustainable implementation.A qualitative research method was used. Semi-structured interviews were held with nine principals and eight special education needs coordinators, working in nine secondary schools that apply MASS. Inductive content analysis was carried out.The main reasons for schools to address medical absenteeism were their concerns about students' well-being and future prospects and their wish to share these concerns with students' parents. Participants also mentioned the wish to raise the threshold for reporting sick. According to the participants, MASS makes it easier for teachers to enter into conversation with students and their parents about medical absence. MASS prevents damage to the relationship with parents and medical problems being missed. In implementing MASS the main obstacles are teachers' dialogue about medical absence with students and their parents, teachers' follow-up of the feedback of the youth health care physicians (YHCPs, and correct registration. The participants were convinced that MASS also improves collaboration with parents regarding the optimization of care for students.MASS allows schools to identify students at risk of dropout at an early stage and to optimise guidance of these students. The intervention matches schools' need to address medical absenteeism by providing a

  10. Attitudes towards Addressing Medical Absenteeism of Students: A Qualitative Study among Principals and Special Education Needs Coordinators in Dutch Secondary Schools.

    Science.gov (United States)

    Vanneste, Yvonne; van de Loo, Marlou; Feron, Frans; Rots-de Vries, Carin; van de Goor, Ien

    2016-01-01

    Reducing school absenteeism benefits the health and educational opportunities of young people. The Dutch intervention Medical Advice for Sick-reported Students (abbreviated as MASS) was developed to address school absenteeism due to sickness reporting, also called medical absenteeism. This study is part of a research project on the effectiveness of MASS and explores factors that influence the implementation and dissemination of the intervention, from schools' perspectives. The research questions include reasons schools have to implement MASS, their experiences in the implementation of MASS and their views on what is needed to ensure sustainable implementation. A qualitative research method was used. Semi-structured interviews were held with nine principals and eight special education needs coordinators, working in nine secondary schools that apply MASS. Inductive content analysis was carried out. The main reasons for schools to address medical absenteeism were their concerns about students' well-being and future prospects and their wish to share these concerns with students' parents. Participants also mentioned the wish to raise the threshold for reporting sick. According to the participants, MASS makes it easier for teachers to enter into conversation with students and their parents about medical absence. MASS prevents damage to the relationship with parents and medical problems being missed. In implementing MASS the main obstacles are teachers' dialogue about medical absence with students and their parents, teachers' follow-up of the feedback of the youth health care physicians (YHCPs), and correct registration. The participants were convinced that MASS also improves collaboration with parents regarding the optimization of care for students. MASS allows schools to identify students at risk of dropout at an early stage and to optimise guidance of these students. The intervention matches schools' need to address medical absenteeism by providing a clear framework

  11. 电化学聚合漆酚钴膜引发甲基丙烯酸甲酯(MMA)聚合的研究%Study on the Cobalt Electropolyurushiol Coordination Polymer Membrane for MMA Polymerization

    Institute of Scientific and Technical Information of China (English)

    唐洁渊; 章文贡; 高锋

    2001-01-01

    利用电化学技术合成的聚合漆酚(EPU)与氯化钴的异丙醇溶液反应, 得到电化学聚合漆酚钴配合物膜. 经XPS光电子能谱、红外光谱、 TG-DTA、动态机械热分析(DMTA)以及原子发射光谱(AES)等手段进行表征并确定其结构. 由于每个钴离子与EPU分子中两个链节单元的羟基发生配位并引起进一步交联, 因此玻璃化转变温度和耐热性能均得到提高. 实验表明, 在常温下的Na2SO3水体系(pH值为7)中配合物膜能引发甲基丙烯酸甲酯(MMA)聚合.%A membrane of cobalt electropolyurushiol coordination polymer was obtained by the reaction of cobalt chloride isopropyl alcohol solution with electropolyurushiol. The membrane of the coordination polymer was characterized using XPS, FT-IR, TG-DTA , DMTA and AES techniques, and its composition and structure were determined. Each Co2+ ion is coordinated by hydroxyl groups from two units in the EPU molecule, and cross-link was further formed because of the produced coordination. Therefore its glass transition temperture increased and the heat resistance enhanced considerably. Experimental results indicated, the coordination polymer membrane activated by Na2SO3 can catalyze polymerization of MMA in water phase at room temperature.

  12. Amniotic membrane transplant with a special technique (Motowa′s sandwich technique in Mooren′s ulcer

    Directory of Open Access Journals (Sweden)

    Saeed Al Motowa

    2015-01-01

    Amniotic membrane transplant with "Motowa′s sandwich technique" resulted in the preservation of the anatomical integrity and progression of disease was halted along with an improved vision. This technique is a novel surgical modality in treating Mooren′s ulcer. Further study on a large cohort of patients is required for evidence-based data to verify the outcome of this initial case report.

  13. One Family's Journey: Medical Home and the Network of Supports It Offers Children and Youth with Special Health Care Needs, Part Two--Care Coordination

    Science.gov (United States)

    Kondrad, Monica; Zehr, Bonnie; Hanna, Christine; Rote, Vicki; Jain, Sweety

    2007-01-01

    The Medical Home series follows fictional parents Amita and Samir and their premature daughter, Anjali. In Part Two, Amita and Samir bring Anjali home from the hospital, contact the care coordinator who will be responsible for Anjali's care, and go to their first appointment with the pediatrician. Emphasis is placed on the manner in which the…

  14. Activated sludge model (ASM) based modelling of membrane bioreactor (MBR) processes: a critical review with special regard to MBR specificities.

    Science.gov (United States)

    Fenu, A; Guglielmi, G; Jimenez, J; Spèrandio, M; Saroj, D; Lesjean, B; Brepols, C; Thoeye, C; Nopens, I

    2010-08-01

    Membrane bioreactors (MBRs) have been increasingly employed for municipal and industrial wastewater treatment in the last decade. The efforts for modelling of such wastewater treatment systems have always targeted either the biological processes (treatment quality target) as well as the various aspects of engineering (cost effective design and operation). The development of Activated Sludge Models (ASM) was an important evolution in the modelling of Conventional Activated Sludge (CAS) processes and their use is now very well established. However, although they were initially developed to describe CAS processes, they have simply been transferred and applied to MBR processes. Recent studies on MBR biological processes have reported several crucial specificities: medium to very high sludge retention times, high mixed liquor concentration, accumulation of soluble microbial products (SMP) rejected by the membrane filtration step, and high aeration rates for scouring purposes. These aspects raise the question as to what extent the ASM framework is applicable to MBR processes. Several studies highlighting some of the aforementioned issues are scattered through the literature. Hence, through a concise and structured overview of the past developments and current state-of-the-art in biological modelling of MBR, this review explores ASM-based modelling applied to MBR processes. The work aims to synthesize previous studies and differentiates between unmodified and modified applications of ASM to MBR. Particular emphasis is placed on influent fractionation, biokinetics, and soluble microbial products (SMPs)/exo-polymeric substances (EPS) modelling, and suggestions are put forward as to good modelling practice with regard to MBR modelling both for end-users and academia. A last section highlights shortcomings and future needs for improved biological modelling of MBR processes.

  15. Indexes of development of sensomotor coordination of people that training calisthenics on the stages of preproduction basic and special basic training.

    Directory of Open Access Journals (Sweden)

    Andreeva M.O.

    2011-08-01

    Full Text Available The studies sensomotory coordination (SMC engaged in rhythmic gymnastics at the age of 9-11 years. The estimation of specific technical preparedness of young gymnasts, based on analysis of the implementation of basic exercises with objects. Revealed substantial reserves in the movements of the subjects to improve the quality management system as the basis of technical competencies in the performance of throwing and catching objects

  16. Generalized Latitude and Longitude in a General Riemannian Space, with a Specialization for Hotine’s (Omega, Phi, Nu) Coordinate System

    Science.gov (United States)

    1991-02-01

    is a general vector in space. The derivation of the Mainardi -Codazzi equations in (6.21) and later in (8.23) of [H] makes use of the above formula (4...position w and 0 were intended as the first two coordinates. He considered two of these conditions to be the Mainardi -Codazzi equations. He formulated three...conditions represented by the Mainardi -Codazzi equations are weaker than (4), or, equivalently, weaker than (2), which, in any event, allows for spaces other

  17. Differences in physical fitness and gross motor coordination in boys aged 6-12 years specializing in one versus sampling more than one sport.

    NARCIS (Netherlands)

    Fransen, J.; Pion, J.; Vandendriessche, J.; Vandorpe, B.; Vaeyens, R.; Lenoir, M.; Philippaerts, R.M.

    2012-01-01

    The Developmental Model of Sports Participation proposes two pathways towards expertise in sports between 6 and 12 years of age: early specialization and early diversification. This study investigated the effect of sampling various sports and of spending many or few hours in sports on fitness and gr

  18. Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation.

    Science.gov (United States)

    Jamal, Janattul-Ain; Economou, Caleb J P; Lipman, Jeffrey; Roberts, Jason A

    2012-10-01

    Antibiotic dosing for critically ill patients that is derived from other patient groups is likely to be suboptimal because of significant antibiotic pharmacokinetic changes, particularly in terms of drug volume of distribution and clearance. Organ support techniques including renal replacement therapy (RRT) and extracorporeal membrane oxygenation (ECMO) increase the pharmacokinetic variability. This article reviews the recently published antibiotic pharmacokinetic data associated with burns patients, those receiving continuous RRT (CRRT), sustained low-efficiency dialysis (SLED) and ECMO. These groups develop increases in volume of distribution that necessitate the use of higher initial doses to rapidly achieve therapeutic antibiotic concentrations. Burns patients have supranormal drug clearances requiring more frequent administration of antibiotics. Patients receiving CRRT or SLED have variable drug clearances related to different equipment and RRT settings at different institutions. ECMO presents a different challenge because there is such a dearth of data with higher than standard doses potentially required, even in the presence of end-organ failure. In the context of such variable pharmacokinetics, a guideline approach to dosing remains elusive because of insufficient available data and, therefore, use of therapeutic drug monitoring should be considered advantageous where possible.

  19. Organization and function of membrane contact sites.

    Science.gov (United States)

    Helle, Sebastian C J; Kanfer, Gil; Kolar, Katja; Lang, Alexander; Michel, Agnès H; Kornmann, Benoît

    2013-11-01

    Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell, allowing the segregation of sometimes incompatible biochemical reactions into specific compartments with tailored microenvironments. On the flip side, these isolating membranes that crowd the interior of the cell, constitute a hindrance to the diffusion of metabolites and information to all corners of the cell. To ensure coordination of cellular activities, cells use a network of contact sites between the membranes of different organelles. These membrane contact sites (MCSs) are domains where two membranes come to close proximity, typically less than 30nm. Such contacts create microdomains that favor exchange between two organelles. MCSs are established and maintained in durable or transient states by tethering structures, which keep the two membranes in proximity, but fusion between the membranes does not take place. Since the endoplasmic reticulum (ER) is the most extensive cellular membrane network, it is thus not surprising to find the ER involved in most MCSs within the cell. The ER contacts diverse compartments such as mitochondria, lysosomes, lipid droplets, the Golgi apparatus, endosomes and the plasma membrane. In this review, we will focus on the common organizing principles underlying the many MCSs found between the ER and virtually all compartments of the cell, and on how the ER establishes a network of MCSs for the trafficking of vital metabolites and information. This article is part of a Special Issue entitled: Functional and structural diversity of endoplasmic reticulum. Copyright © 2013 Elsevier B.V. All rights reserved.

  20. A Coordinate-Based Meta-Analysis of Overlaps in Regional Specialization and Functional Connectivity across Subjective Value and Default Mode Networks

    Science.gov (United States)

    Acikalin, M. Yavuz; Gorgolewski, Krzysztof J.; Poldrack, Russell A.

    2017-01-01

    Previous research has provided qualitative evidence for overlap in a number of brain regions across the subjective value network (SVN) and the default mode network (DMN). In order to quantitatively assess this overlap, we conducted a series of coordinate-based meta-analyses (CBMA) of results from 466 functional magnetic resonance imaging experiments on task-negative or subjective value-related activations in the human brain. In these analyses, we first identified significant overlaps and dissociations across activation foci related to SVN and DMN. Second, we investigated whether these overlapping subregions also showed similar patterns of functional connectivity, suggesting a shared functional subnetwork. We find considerable overlap between SVN and DMN in subregions of central ventromedial prefrontal cortex (cVMPFC) and dorsal posterior cingulate cortex (dPCC). Further, our findings show that similar patterns of bidirectional functional connectivity between cVMPFC and dPCC are present in both networks. We discuss ways in which our understanding of how subjective value (SV) is computed and represented in the brain can be synthesized with what we know about the DMN, mind-wandering, and self-referential processing in light of our findings. PMID:28154520

  1. Special relativity

    CERN Document Server

    Faraoni, Valerio

    2013-01-01

    This book offers an essential bridge between college-level introductions and advanced graduate-level books on special relativity. It begins at an elementary level, presenting and discussing the basic concepts normally covered in college-level works, including the Lorentz transformation. Subsequent chapters introduce the four-dimensional worldview implied by the Lorentz transformations, mixing time and space coordinates, before continuing on to the formalism of tensors, a topic usually avoided in lower-level courses. The book’s second half addresses a number of essential points, including the concept of causality; the equivalence between mass and energy, including applications; relativistic optics; and measurements and matter in Minkowski spacetime. The closing chapters focus on the energy-momentum tensor of a continuous distribution of mass-energy and its covariant conservation; angular momentum; a discussion of the scalar field of perfect fluids and the Maxwell field; and general coordinates. Every chapter...

  2. Poisson Coordinates.

    Science.gov (United States)

    Li, Xian-Ying; Hu, Shi-Min

    2013-02-01

    Harmonic functions are the critical points of a Dirichlet energy functional, the linear projections of conformal maps. They play an important role in computer graphics, particularly for gradient-domain image processing and shape-preserving geometric computation. We propose Poisson coordinates, a novel transfinite interpolation scheme based on the Poisson integral formula, as a rapid way to estimate a harmonic function on a certain domain with desired boundary values. Poisson coordinates are an extension of the Mean Value coordinates (MVCs) which inherit their linear precision, smoothness, and kernel positivity. We give explicit formulas for Poisson coordinates in both continuous and 2D discrete forms. Superior to MVCs, Poisson coordinates are proved to be pseudoharmonic (i.e., they reproduce harmonic functions on n-dimensional balls). Our experimental results show that Poisson coordinates have lower Dirichlet energies than MVCs on a number of typical 2D domains (particularly convex domains). As well as presenting a formula, our approach provides useful insights for further studies on coordinates-based interpolation and fast estimation of harmonic functions.

  3. 45 CFR 1310.23 - Coordinated transportation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Coordinated transportation. 1310.23 Section 1310... START PROGRAM HEAD START TRANSPORTATION Special Requirements § 1310.23 Coordinated transportation. (a) Each agency providing transportation services must make reasonable efforts to coordinate...

  4. Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy.

    Science.gov (United States)

    Ottmann, Christian; Marco, Sergio; Jaspert, Nina; Marcon, Caroline; Schauer, Nicolas; Weyand, Michael; Vandermeeren, Caroline; Duby, Geoffrey; Boutry, Marc; Wittinghofer, Alfred; Rigaud, Jean-Louis; Oecking, Claudia

    2007-02-09

    Regulatory 14-3-3 proteins activate the plant plasma membrane H(+)-ATPase by binding to its C-terminal autoinhibitory domain. This interaction requires phosphorylation of a C-terminal, mode III, recognition motif as well as an adjacent span of approximately 50 amino acids. Here we report the X-ray crystal structure of 14-3-3 in complex with the entire binding motif, revealing a previously unidentified mode of interaction. A 14-3-3 dimer simultaneously binds two H(+)-ATPase peptides, each of which forms a loop within the typical 14-3-3 binding groove and therefore exits from the center of the dimer. Several H(+)-ATPase mutants support this structure determination. Accordingly, 14-3-3 binding could result in H(+)-ATPase oligomerization. Indeed, by using single-particle electron cryomicroscopy, the 3D reconstruction of the purified H(+)-ATPase/14-3-3 complex demonstrates a hexameric arrangement. Fitting of 14-3-3 and H(+)-ATPase atomic structures into the 3D reconstruction map suggests the spatial arrangement of the holocomplex.

  5. CPN Models in General Coordinates

    CERN Document Server

    Barnes, K J

    2002-01-01

    An analysis of CPN models is given in terms of general coordinates or arbitrary interpolating fields.Only closed expressions made from simple functions are involved.Special attention is given to CP2 and CP4. In the first of these the retrieval of stereographic coordinates reveals the hermitian form of the metric. A similar analysis for the latter case allows comparison with the Fubini-Study metric.

  6. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    Overview From a technical perspective, CMS has been in “beam operation” state since 6th November. The detector is fully closed with all components operational and the magnetic field is normally at the nominal 3.8T. The UXC cavern is normally closed with the radiation veto set. Access to UXC is now only possible during downtimes of LHC. Such accesses must be carefully planned, documented and carried out in agreement with CMS Technical Coordination, Experimental Area Management, LHC programme coordination and the CCC. Material flow in and out of UXC is now strictly controlled. Access to USC remains possible at any time, although, for safety reasons, it is necessary to register with the shift crew in the control room before going down.It is obligatory for all material leaving UXC to pass through the underground buffer zone for RP scanning, database entry and appropriate labeling for traceability. Technical coordination (notably Stephane Bally and Christoph Schaefer), the shift crew and run ...

  7. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    2010-01-01

    Operational Experience At the end of the first full-year running period of LHC, CMS is established as a reliable, robust and mature experiment. In particular common systems and infrastructure faults accounted for <0.6 % CMS downtime during LHC pp physics. Technical operation throughout the entire year was rather smooth, the main faults requiring UXC access being sub-detector power systems and rack-cooling turbines. All such problems were corrected during scheduled technical stops, in the shadow of tunnel access needed by the LHC, or in negotiated accesses or access extensions. Nevertheless, the number of necessary accesses to the UXC averaged more than one per week and the technical stops were inevitably packed with work packages, typically 30 being executed within a few days, placing a high load on the coordination and area management teams. It is an appropriate moment for CMS Technical Coordination to thank all those in many CERN departments and in the Collaboration, who were involved in CMS techni...

  8. Special Use Airspace Management System

    Data.gov (United States)

    Department of Transportation — The Special-Use Airspace Management System (SAMS) supports the FAA military operations (MILOPS) mission. It automates the coordination of FAA and U.S. Department of...

  9. Some Pitfalls in Special Relativity

    Science.gov (United States)

    Chai, An-Ti

    1973-01-01

    The problem of observing a collision between two spaceships is utilized to illustrate the misuse of time dilation and length contraction, and the incorrect description of space-time coordinates in special relativity. (Author/DF)

  10. 23 CFR 810.8 - Coordination.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Coordination. 810.8 Section 810.8 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS General § 810.8 Coordination. The Federal Highway Administrator and the Urban...

  11. 47 CFR 95.1111 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequency coordination. 95.1111 Section 95.1111 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Wireless Medical Telemetry Service (WMTS) General Provisions § 95.1111 Frequency coordination....

  12. 47 CFR 80.513 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequency coordination. 80.513 Section 80.513 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Private Coast Stations and Marine Utility Stations § 80.513 Frequency coordination....

  13. Coordination Capacity

    CERN Document Server

    Cuff, Paul; Cover, Thomas

    2009-01-01

    We develop elements of a theory of cooperation and coordination in networks. Rather than considering a communication network as a means of distributing information, or of reconstructing random processes at remote nodes, we ask what dependence can be established among the nodes given the communication constraints. Specifically, in a network with communication rates between the nodes, we ask what is the set of all achievable joint distributions p(x1, ..., xm) of actions at the nodes on the network. Several networks are solved, including arbitrarily large cascade networks. Distributed cooperation can be the solution to many problems such as distributed games, distributed control, and establishing mutual information bounds on the influence of one part of a physical system on another.

  14. Enterprise Coordination on the Internet

    Directory of Open Access Journals (Sweden)

    Charles Petrie

    2011-02-01

    Full Text Available Enterprises are now connected internally and externally to other Enterprises via the Internet in ways that are increasingly difficult to manage, especially as these interconnections become more dynamic. Current methods of coordinating the effects of change as they propagate through these networks of connections are not likely to scale. What is needed is a new paradigm for how the Internet supports such coordination. Indeed, the Internet should and could provide fundamental coordination functions that are missing today. In this paper, we describe how such a “Coordinated Internet” would work (this paper is an expanded version of [1]. The key functionality of a Coordinated Internet would be that the Internet actively watches what people do (analogous to search completion on desktops today, correlates these activities, and actively notifies people when and how their current tasks affect and are affected by the activities of other people. This would be accomplished by standard coordination functions implemented as a common Internet layer that can be used as a utility by more specialized applications. Such a Coordinated Internet would revolutionize enterprise management, for all enterprises, large and small, corporate and personal. For example, static workflows would become obsolete for all but the the most routine processes. Some solutions provide existence proofs of such a coordination substrate, such as the Redux solution in concurrent engineering, which we describe herein. However, foundational research remains to be done in the new field of Coordination Engineering in order to reach the goal of a future Internet in which coordination functions are fundamental.

  15. RUN COORDINATION

    CERN Multimedia

    C. Delaere

    2013-01-01

    Since the LHC ceased operations in February, a lot has been going on at Point 5, and Run Coordination continues to monitor closely the advance of maintenance and upgrade activities. In the last months, the Pixel detector was extracted and is now stored in the pixel lab in SX5; the beam pipe has been removed and ME1/1 removal has started. We regained access to the vactank and some work on the RBX of HB has started. Since mid-June, electricity and cooling are back in S1 and S2, allowing us to turn equipment back on, at least during the day. 24/7 shifts are not foreseen in the next weeks, and safety tours are mandatory to keep equipment on overnight, but re-commissioning activities are slowly being resumed. Given the (slight) delays accumulated in LS1, it was decided to merge the two global runs initially foreseen into a single exercise during the week of 4 November 2013. The aim of the global run is to check that we can run (parts of) CMS after several months switched off, with the new VME PCs installed, th...

  16. RUN COORDINATION

    CERN Multimedia

    Christophe Delaere

    2013-01-01

    The focus of Run Coordination during LS1 is to monitor closely the advance of maintenance and upgrade activities, to smooth interactions between subsystems and to ensure that all are ready in time to resume operations in 2015 with a fully calibrated and understood detector. After electricity and cooling were restored to all equipment, at about the time of the last CMS week, recommissioning activities were resumed for all subsystems. On 7 October, DCS shifts began 24/7 to allow subsystems to remain on to facilitate operations. That culminated with the Global Run in November (GriN), which   took place as scheduled during the week of 4 November. The GriN has been the first centrally managed operation since the beginning of LS1, and involved all subdetectors but the Pixel Tracker presently in a lab upstairs. All nights were therefore dedicated to long stable runs with as many subdetectors as possible. Among the many achievements in that week, three items may be highlighted. First, the Strip...

  17. Public Relations for Special Education.

    Science.gov (United States)

    Steinke, Gary L.; Steinke, Roberta J.

    This paper offers suggestions to help special educators and administrators effectively and thoroughly tell people about their school's programs and events dealing with special education. General suggestions include appointing a public relations coordinator, having school personnel complete a Public Relations Help Request Form when publicizing…

  18. Program specialization

    CERN Document Server

    Marlet, Renaud

    2013-01-01

    This book presents the principles and techniques of program specialization - a general method to make programs faster (and possibly smaller) when some inputs can be known in advance. As an illustration, it describes the architecture of Tempo, an offline program specializer for C that can also specialize code at runtime, and provides figures for concrete applications in various domains. Technical details address issues related to program analysis precision, value reification, incomplete program specialization, strategies to exploit specialized program, incremental specialization, and data speci

  19. Sheet Membrane Spacesuit Water Membrane Evaporator

    Science.gov (United States)

    Bue, Grant; Trevino, Luis; Zapata, Felipe; Dillion, Paul; Castillo, Juan; Vonau, Walter; Wilkes, Robert; Vogel, Matthew; Frodge, Curtis

    2013-01-01

    A document describes a sheet membrane spacesuit water membrane evaporator (SWME), which allows for the use of one common water tank that can supply cooling water to the astronaut and to the evaporator. Test data showed that heat rejection performance dropped only 6 percent after being subjected to highly contaminated water. It also exhibited robustness with respect to freezing and Martian atmospheric simulation testing. Water was allowed to freeze in the water channels during testing that simulated a water loop failure and vapor backpressure valve failure. Upon closing the backpressure valve and energizing the pump, the ice eventually thawed and water began to flow with no apparent damage to the sheet membrane. The membrane evaporator also serves to de-gas the water loop from entrained gases, thereby eliminating the need for special degassing equipment such as is needed by the current spacesuit system. As water flows through the three annular water channels, water evaporates with the vapor flowing across the hydrophobic, porous sheet membrane to the vacuum side of the membrane. The rate at which water evaporates, and therefore, the rate at which the flowing water is cooled, is a function of the difference between the water saturation pressure on the water side of the membrane, and the pressure on the vacuum side of the membrane. The primary theory is that the hydrophobic sheet membrane retains water, but permits vapor pass-through when the vapor side pressure is less than the water saturation pressure. This results in evaporative cooling of the remaining water.

  20. The 3rd CARISMA international conference on medium and high temperature proton exchange membrane fuel cells: Three approaches to better platinum catalysts at biannual conference

    DEFF Research Database (Denmark)

    Jensen, Jens Oluf; Cleemann, Lars Nilausen; Li, Qingfeng

    2013-01-01

    The 3rd CARISMA International Conference was held at the Axelborg venue in Copenhagen, Denmark, from September 3-5, 2012. The CARISMA conference series was specifically devoted to challenges in the development and testing of fuel cell materials and membrane electrode assemblies (MEAs) for proton...... exchange membrane fuel cells (PEMFCs) to be operated at intermediate and high temperatures. The conference series was initiated by the European CARISMA Coordination Action for Research on Intermediate and High Temperature Specialized Membrane Electrode Assemblies. The 2012 event in Copenhagen had around...

  1. Motor coordination: a local hub for coordination.

    Science.gov (United States)

    Calabrese, Ronald L

    2014-03-31

    A local interneuron of a crayfish central pattern generator serves as a hub that integrates ascending and descending coordinating information and passes it on to a local oscillatory microcircuit to coordinate a series of segmental appendages known as swimmerets.

  2. Reaction Coordinates and Mechanistic Hypothesis Tests.

    Science.gov (United States)

    Peters, Baron

    2016-05-27

    Reaction coordinates are integral to several classic rate theories that can (a) predict kinetic trends across conditions and homologous reactions, (b) extract activation parameters with a clear physical interpretation from experimental rates, and (c) enable efficient calculations of free energy barriers and rates. New trajectory-based rare events methods can provide rates directly from dynamical trajectories without a reaction coordinate. Trajectory-based frameworks can also generate ideal (but abstract) reaction coordinates such as committors and eigenfunctions of the master equation. However, rates and mechanistic insights obtained from trajectory-based methods and abstract coordinates are not readily generalized across simulation conditions or reaction families. We discuss methods for identifying physically meaningful reaction coordinates, including committor analysis, variational transition state theory, Kramers-Langer-Berezhkovskii-Szabo theory, and statistical inference methods that can use path sampling data to screen, mix, and optimize thousands of trial coordinates. Special focus is given to likelihood maximization and inertial likelihood maximization approaches.

  3. Reaction Coordinates and Mechanistic Hypothesis Tests

    Science.gov (United States)

    Peters, Baron

    2016-05-01

    Reaction coordinates are integral to several classic rate theories that can (a) predict kinetic trends across conditions and homologous reactions, (b) extract activation parameters with a clear physical interpretation from experimental rates, and (c) enable efficient calculations of free energy barriers and rates. New trajectory-based rare events methods can provide rates directly from dynamical trajectories without a reaction coordinate. Trajectory-based frameworks can also generate ideal (but abstract) reaction coordinates such as committors and eigenfunctions of the master equation. However, rates and mechanistic insights obtained from trajectory-based methods and abstract coordinates are not readily generalized across simulation conditions or reaction families. We discuss methods for identifying physically meaningful reaction coordinates, including committor analysis, variational transition state theory, Kramers-Langer-Berezhkovskii-Szabo theory, and statistical inference methods that can use path sampling data to screen, mix, and optimize thousands of trial coordinates. Special focus is given to likelihood maximization and inertial likelihood maximization approaches.

  4. Validating Basic Surface Variables in the Australian Bureau of Meteorology Model with CEOP EOP3 In-situ Data(<Special Issue>Coordinated Enhanced Observing Period(CEOP))

    OpenAIRE

    Lawrie, RIKUS; Bureau of Meteorology Research Centre

    2007-01-01

    The Coordinated Enhanced Observing Period (CEOP) Project has initiated the collection of model output location time series (MOLTS) data from numerical weather prediction and assimilation centers, including the Australian Bureau of Meteorology. These were designed to complement the collection of in-situ observational data sets at the same 41 locations. This study is a preliminary attempt to assess the differences and similarities between the MOLTS and time series of the in-situ data. The MOLTS...

  5. Calpains, cleaved mini-dysferlinC72, and L-type channels underpin calcium-dependent muscle membrane repair.

    Science.gov (United States)

    Lek, Angela; Evesson, Frances J; Lemckert, Frances A; Redpath, Gregory M I; Lueders, Ann-Katrin; Turnbull, Lynne; Whitchurch, Cynthia B; North, Kathryn N; Cooper, Sandra T

    2013-03-20

    Dysferlin is proposed as a key mediator of calcium-dependent muscle membrane repair, although its precise role has remained elusive. Dysferlin interacts with a new membrane repair protein, mitsugumin 53 (MG53), an E3 ubiquitin ligase that shows rapid recruitment to injury sites. Using a novel ballistics assay in primary human myotubes, we show it is not full-length dysferlin recruited to sites of membrane injury but an injury-specific calpain-cleavage product, mini-dysferlinC72. Mini-dysferlinC72-rich vesicles are rapidly recruited to injury sites and fuse with plasma membrane compartments decorated by MG53 in a process coordinated by L-type calcium channels. Collective interplay between activated calpains, dysferlin, and L-type channels explains how muscle cells sense a membrane injury and mount a specialized response in the unique local environment of a membrane injury. Mini-dysferlinC72 and MG53 form an intricate lattice that intensely labels exposed phospholipids of injury sites, then infiltrates and stabilizes the membrane lesion during repair. Our results extend functional parallels between ferlins and synaptotagmins. Whereas otoferlin exists as long and short splice isoforms, dysferlin is subject to enzymatic cleavage releasing a synaptotagmin-like fragment with a specialized protein- or phospholipid-binding role for muscle membrane repair.

  6. Membrane dynamics

    DEFF Research Database (Denmark)

    Bendix, Pól Martin

    2015-01-01

    Current topics include membrane-protein interactions with regard to membrane deformation or curvature sensing by BAR domains. Also, we study the dynamics of membrane tubes of both cells and simple model membrane tubes. Finally, we study membrane phase behavior which has important implications...... for the lateral organization of membranes as wells as for physical properties like bending, permeability and elasticity...

  7. Specialization Patterns

    DEFF Research Database (Denmark)

    Schultz, Ulrik Pagh; Lawall, Julia Laetitia; Consel, Charles

    2000-01-01

    Design patterns offer many advantages for software development, but can introduce inefficiency into the final program. Program specialization can eliminate such overheads, but is most effective when targeted by the user to specific bottlenecks. Consequently, we propose that these concepts...... are complementary. Program specialization can optimize programs written using design patterns, and design patterns provide information about the program structure that can guide specialization. Concretely, we propose specialization patterns, which describe how to apply program specialization to optimize uses...... of design patterns. In this paper, we analyze the specialization opportunities provided by specific uses of design patterns. Based on the analysis of each design pattern, we define the associated specialization pattern. These specialization opportunities can be declared using the specialization classes...

  8. Limitations of Radar Coordinates

    OpenAIRE

    Bini, Donato; Lusanna, Luca; Mashhoon, Bahram

    2004-01-01

    The construction of a radar coordinate system about the world line of an observer is discussed. Radar coordinates for a hyperbolic observer as well as a uniformly rotating observer are described in detail. The utility of the notion of radar distance and the admissibility of radar coordinates are investigated. Our results provide a critical assessment of the physical significance of radar coordinates.

  9. Cuba's National Clinical Trials Coordinating Center: emergence, evolution, and main results. Translated from the Spanish and reprinted with permission from the Revista Cubana de Farmacia. Vol. 44 No. 2 (special supplement), Apr-Jun 2010.

    Science.gov (United States)

    López, María A Pascual; Rivero, Gladys Jiménez; Pombert, Ania Torres; López, Martha María Fors; Zayas, Isabel López

    2011-01-01

    The rapid development of Cuba's pharmaceutical industry in the 1990s created a need for structures to ensure clinical evaluation of products before their introduction into medical practice and subsequent marketing. One of the centers founded for this purpose was the National Clinical Trials Coordinating Center. This paper summarizes the factors that motivated the creation of the Center and presents a brief history of its organizational development over the last 17 years. It also describes the main components of the system for designing and conducting clinical trials, and the most significant contributions of each toward achieving the Center's objectives.

  10. Focus on Membrane Differentiation and Membrane Domains in the Prokaryotic Cell

    OpenAIRE

    Boekema, Egbert J.; Scheffers, Dirk-Jan; van Bezouwen, Laura S.; Bolhuis, Henk; Folea, I. Mihaela

    2013-01-01

    A summary is presented of membrane differentiation in the prokaryotic cell, with an emphasis on the organization of proteins in the plasma/cell membrane. Many species belonging to the Eubacteria and Archaea have special membrane domains and/or membrane proliferation, which are vital for different cellular processes. Typical membrane domains are found in bacteria where a specific membrane protein is abundantly expressed. Lipid rafts form another example. Despite the rareness of conventional or...

  11. Focus on Membrane Differentiation and Membrane Domains in the Prokaryotic Cell

    NARCIS (Netherlands)

    Boekema, E.J.; Scheffers, D.-J.; van Bezouwen, L.S.; Bolhuis, H.; Folea, I.M.

    2013-01-01

    A summary is presented of membrane differentiation in the prokaryotic cell, with an emphasis on the organization of proteins in the plasma/cell membrane. Many species belonging to the Eubacteria and Archaea have special membrane domains and/or membrane proliferation, which are vital for different

  12. Movement and Coordination

    Science.gov (United States)

    ... Español Text Size Email Print Share Movement and Coordination Page Content Article Body At this age, your ... level will strengthen his body and develop his coordination. In the months ahead, your child’s running will ...

  13. Developmental coordination disorder

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/001533.htm Developmental coordination disorder To use the sharing features on this page, please enable JavaScript. Developmental coordination disorder is a childhood disorder. It leads to ...

  14. Special Theory of Relativity without special assumptions and tachyonic motion

    Directory of Open Access Journals (Sweden)

    E. Kapuścik

    2010-01-01

    Full Text Available The most general form of transformations of space-time coordinates in Special Theory of Relativity based solely on physical assumptions is described. Only the linearity of space-time transformations and the constancy of the speed of light are used as assumptions. The application to tachyonic motion is indicated.

  15. Coordination and Cooperation

    OpenAIRE

    Janssen, Maarten

    2003-01-01

    textabstractThis comment makes four related points. First, explaining coordination is different from explaining cooperation. Second, solving the coordination problem is more important for the theory of games than solving the cooperation problem. Third, a version of the Principle of Coordination can be rationalized on individualistic grounds. Finally, psychological game theory should consider how players perceive their gaming situation. ---------------------------------------------------------...

  16. Processing Coordination Ambiguity

    Science.gov (United States)

    Engelhardt, Paul E.; Ferreira, Fernanda

    2010-01-01

    We examined temporarily ambiguous coordination structures such as "put the butter in the bowl and the pan on the towel." Minimal Attachment predicts that the ambiguous noun phrase "the pan" will be interpreted as a noun-phrase coordination structure because it is syntactically simpler than clausal coordination. Constraint-based theories assume…

  17. Processing Coordination Ambiguity

    Science.gov (United States)

    Engelhardt, Paul E.; Ferreira, Fernanda

    2010-01-01

    We examined temporarily ambiguous coordination structures such as "put the butter in the bowl and the pan on the towel." Minimal Attachment predicts that the ambiguous noun phrase "the pan" will be interpreted as a noun-phrase coordination structure because it is syntactically simpler than clausal coordination. Constraint-based…

  18. Coordination and Cooperation

    NARCIS (Netherlands)

    M.C.W. Janssen (Maarten)

    2003-01-01

    textabstractThis comment makes four related points. First, explaining coordination is different from explaining cooperation. Second, solving the coordination problem is more important for the theory of games than solving the cooperation problem. Third, a version of the Principle of Coordination can

  19. Coordination and Cooperation

    NARCIS (Netherlands)

    M.C.W. Janssen (Maarten)

    2003-01-01

    textabstractThis comment makes four related points. First, explaining coordination is different from explaining cooperation. Second, solving the coordination problem is more important for the theory of games than solving the cooperation problem. Third, a version of the Principle of Coordination can

  20. Special Weapons

    Data.gov (United States)

    Federal Laboratory Consortium — Supporting Navy special weapons, the division provides an array of engineering services, technical publication support services, logistics support services, safety...

  1. Deriving force field parameters for coordination complexes

    DEFF Research Database (Denmark)

    Norrby, Per-Ola; Brandt, Peter

    2001-01-01

    The process of deriving molecular mechanics force fields for coordination complexes is outlined. Force field basics are introduced with an emphasis on special requirements for metal complexes. The review is then focused on how to set up the initial model, define the target, refine the parameters,...

  2. Membrane reactor. Membrane reactor

    Energy Technology Data Exchange (ETDEWEB)

    Shindo, Y.; Wakabayashi, K. (National Chemical Laboratory for Industry, Tsukuba (Japan))

    1990-08-05

    Many reaction examples were introduced of membrane reactor, to be on the point of forming a new region in the field of chemical technology. It is a reactor to exhibit excellent function, by its being installed with membrane therein, and is generally classified into catalyst function type and reaction promotion type. What firstly belongs to the former is stabilized zirconia, where oxygen, supplied to the cathodic side of membrane with voltage, impressed thereon, becomes O {sup 2 {minus}} to be diffused through the membrane and supplied, as variously activated oxygenous species, on the anodic side. Examples with many advantages can be given such as methane coupling, propylene oxidation, methanating reaction of carbon dioxide, etc. Apart, palladium film and naphion film also belong to the former. While examples of the latter comprise, among others, decomposition of hydrogen sulfide by porous glass film and dehydrogenation of cyclohexane or palladium alloy film, which are expected to be developed and materialized in the industry. 33 refs., 8 figs.

  3. STUDY ON VIRUCIDAL EFFICACY AND SAFETY OF A DISINFECTANT APPLIED SPECIALLY TO MUCOUS MEMBRANE%一种专用黏膜消毒剂对病毒的灭活效果及安全性研究

    Institute of Scientific and Technical Information of China (English)

    帖金凤; 陈金龙; 王长德; 蒋莉; 张文福

    2011-01-01

    目的 观察一种专用黏膜消毒剂对病毒灭活效果及其毒性.方法 采用细胞感染法和动物毒性试验方法对该消毒剂消毒相关性能进行了实验室和现场消毒试验.结果 用总活性物含量为2 000 mg/L的复合季铵盐该黏膜消毒剂作用1.5 min,对悬液内脊髓灰质炎病毒Ⅰ型疫苗株、狂犬病毒、EV71型肠道病毒和单纯疱疹病毒的平均灭活对数值均>4.00.用相同浓度的该粘膜消毒剂对前臂皮肤擦拭消毒3 min,对皮肤表面的自然菌平均杀灭对数值为1.45.该消毒剂经口急性LD50值>5 000 mg/kg(体重);对小鼠骨髓嗜多染红细胞无致微核作用.该消毒剂原液对家兔破损皮肤、阴道黏膜和眼均无刺激性.结论 该黏膜专用消毒剂对病毒具有较好的灭活效果,属于无毒级物质.%Objective To observe the virucidal efficacy and toxicity of a disinfectant applied specially to mucous membrane. Methods Cell infection method and animal toxicity test were used to observe the disinfection efficacy and toxicity of the disinfectant in laboratory and field test. Results The average killing logarithm values of poliomyelitis virus 1 vaccine strain, rabies virus, EV71 enterovirus and herpes simplex virus in suspension exposed to the compound quaternary ammonium disinfection solution containing gross activity 2 000 mg/L for 1.5 minutes were >4. 00. The natural bacteria on forearm skin surface of volunteer exposed to the disinfection solution at the same concentration for 3 minutes was killed by an average logarithm value 1.45. LD50 of the oral acute toxicity of the disinfectant in mice was > 5000 mg/kg · bw. It could not cause micronucleus formation in mouse bone marrow polychromatic erythrocyte. No irritant effect on damaged skin, vagina mucosa and eye of rabbit was observed. Conclusion The disinfectant applied specially to mucous membrane has good vi-rucidal efficacy, which belonged to nontoxic class.

  4. Trade, Standards and Vertical Coordination: Evidence from The ...

    African Journals Online (AJOL)

    Keywords: Rwanda, Trade Liberalization, FDI, vertical coordination, Standards,. Speciality ... coffee (café marchand) and sell the final on the international market. Office ..... To identify indicators for inclusion in this study and their respective.

  5. Biobased Membrane

    NARCIS (Netherlands)

    Koenders, E.A.B.; Zlopasa, J.; Picken, S.J.

    2015-01-01

    The present invention is in the field of a composition for forming a bio-compatible membrane applicable to building material, such as concrete, cement, etc., to a meth od of applying said composition for forming a bio-compatible membrane, a biocompatible membrane, use of said membrane for various pu

  6. Membrane fusion

    DEFF Research Database (Denmark)

    Bendix, Pól Martin

    2015-01-01

    At Stanford University, Boxer lab, I worked on membrane fusion of small unilamellar lipid vesicles to flat membranes tethered to glass surfaces. This geometry closely resembles biological systems in which liposomes fuse to plasma membranes. The fusion mechanism was studied using DNA zippering...... between complementary strands linked to the two apposing membranes closely mimicking the zippering mechanism of SNARE fusion complexes....

  7. Specialized languages

    DEFF Research Database (Denmark)

    Mousten, Birthe; Laursen, Anne Lise

    2016-01-01

    -disciplinarily, because they work with both derivative and contributory approaches. Derivative, because specialized language retrieves its philosophy of science as well as methods from both the natural sciences, social sciences and humanistic sciences. Contributory because language results support the communication......Across different fields of research, one feature is often overlooked: the use of language for specialized purposes (LSP) as a cross-discipline. Mastering cross-disciplinarity is the precondition for communicating detailed results within any field. Researchers in specialized languages work cross...... science fields communicate their findings. With this article, we want to create awareness of the work in this special area of language studies and of the inherent cross-disciplinarity that makes LSP special compared to common-core language. An acknowledgement of the importance of this field both in terms...

  8. Do Environmental Education School Coordinators Have a Mission?

    Science.gov (United States)

    Šimonová, Petra; Cincera, Jan

    2016-01-01

    Teachers who are specialized in environmental education (environmental education school coordinators) can play an important role in empowering students to shape a sustainable future. In this study, the authors examined a group of Czech environmental education school coordinators. The authors aimed to clarify how they interpret their role at their…

  9. Do Environmental Education School Coordinators Have a Mission?

    Science.gov (United States)

    Šimonová, Petra; Cincera, Jan

    2016-01-01

    Teachers who are specialized in environmental education (environmental education school coordinators) can play an important role in empowering students to shape a sustainable future. In this study, the authors examined a group of Czech environmental education school coordinators. The authors aimed to clarify how they interpret their role at their…

  10. Chromatic adaptation of photosynthetic membranes.

    Science.gov (United States)

    Scheuring, Simon; Sturgis, James N

    2005-07-15

    Many biological membranes adapt in response to environmental conditions. We investigated how the composition and architecture of photosynthetic membranes of a bacterium change in response to light, using atomic force microscopy. Despite large modifications in the membrane composition, the local environment of core complexes remained unaltered, whereas specialized paracrystalline light-harvesting antenna domains grew under low-light conditions. Thus, the protein mixture in the membrane shows eutectic behavior and can be mimicked by a simple model. Such structural adaptation ensures efficient photon capture under low-light conditions and prevents photodamage under high-light conditions.

  11. Enhanced time overcurrent coordination

    Energy Technology Data Exchange (ETDEWEB)

    Enriquez, Arturo Conde; Martinez, Ernesto Vazquez [Universidad Autonoma de Nuevo Leon, Facultad de Ingenieria Mecanica y Electrica, Apdo. Postal 114-F, Ciudad Universitaria, CP 66450 San Nicolas de los Garza, Nuevo Leon (Mexico)

    2006-04-15

    In this paper, we recommend a new coordination system for time overcurrent relays. The purpose of the coordination process is to find a time element function that allows it to operate using a constant back-up time delay, for any fault current. In this article, we describe the implementation and coordination results of time overcurrent relays, fuses and reclosers. Experiments were carried out in a laboratory test situation using signals of a power electrical system physics simulator. (author)

  12. Biophysics of α-synuclein membrane interactions.

    Science.gov (United States)

    Pfefferkorn, Candace M; Jiang, Zhiping; Lee, Jennifer C

    2012-02-01

    Membrane proteins participate in nearly all cellular processes; however, because of experimental limitations, their characterization lags far behind that of soluble proteins. Peripheral membrane proteins are particularly challenging to study because of their inherent propensity to adopt multiple and/or transient conformations in solution and upon membrane association. In this review, we summarize useful biophysical techniques for the study of peripheral membrane proteins and their application in the characterization of the membrane interactions of the natively unfolded and Parkinson's disease (PD) related protein, α-synuclein (α-syn). We give particular focus to studies that have led to the current understanding of membrane-bound α-syn structure and the elucidation of specific membrane properties that affect α-syn-membrane binding. Finally, we discuss biophysical evidence supporting a key role for membranes and α-syn in PD pathogenesis. This article is part of a Special Issue entitled: Membrane protein structure and function.

  13. Membranous nephropathy

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/000472.htm Membranous nephropathy To use the sharing features on this page, please enable JavaScript. Membranous nephropathy is a kidney disorder that leads to changes ...

  14. Characterizing traits of coordination

    NARCIS (Netherlands)

    Poss, R.

    2013-01-01

    How can one recognize coordination languages and technologies? As this report shows, the common approach that contrasts coordination with computation is intellectually unsound: depending on the selected understanding of the word "computation", it either captures too many or too few programming

  15. Coordination models and languages

    NARCIS (Netherlands)

    Papadopoulos, G.A.; Arbab, F.

    1998-01-01

    A new class of models, formalisms and mechanisms has recently evolved for describing concurrent and distributed computations based on the concept of ``coordination''. The purpose of a coordination model and associated language is to provide a means of integrating a number of possibly heterogeneous c

  16. Team coordination dynamics.

    Science.gov (United States)

    Gorman, Jamie C; Amazeen, Polemnia G; Cooke, Nancy J

    2010-07-01

    Team coordination consists of both the dynamics of team member interaction and the environmental dynamics to which a team is subjected. Focusing on dynamics, an approach is developed that contrasts with traditional aggregate-static concepts of team coordination as characterized by the shared mental model approach. A team coordination order parameter was developed to capture momentary fluctuations in coordination. Team coordination was observed in three-person uninhabited air vehicle teams across two experimental sessions. The dynamics of the order parameter were observed under changes of a team familiarity control parameter. Team members returned for the second session to either the same (Intact) or different (Mixed) team. 'Roadblock' perturbations, or novel changes in the task environment, were introduced in order to probe the stability of team coordination. Nonlinear dynamic methods revealed differences that a traditional approach did not: Intact and Mixed team coordination dynamics looked very different; Mixed teams were more stable than Intact teams and explored the space of solutions without the need for correction. Stability was positively correlated with the number of roadblock perturbations that were overcome successfully. The novel and non-intuitive contribution of a dynamical analysis was that Mixed teams, who did not have a long history working together, were more adaptive. Team coordination dynamics carries new implications for traditional problems such as training adaptive teams.

  17. Coordinate measuring machines

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    This document is used in connection with three exercises of 2 hours duration as a part of the course GEOMETRICAL METROLOGY AND MACHINE TESTING. The exercises concern three aspects of coordinate measuring: 1) Measuring and verification of tolerances on coordinate measuring machines, 2) Traceability...

  18. Social Postural Coordination

    Science.gov (United States)

    Varlet, Manuel; Marin, Ludovic; Lagarde, Julien; Bardy, Benoit G.

    2011-01-01

    The goal of the current study was to investigate whether a visual coupling between two people can produce spontaneous interpersonal postural coordination and change their intrapersonal postural coordination involved in the control of stance. We examined the front-to-back head displacements of participants and the angular motion of their hip and…

  19. Social Postural Coordination

    Science.gov (United States)

    Varlet, Manuel; Marin, Ludovic; Lagarde, Julien; Bardy, Benoit G.

    2011-01-01

    The goal of the current study was to investigate whether a visual coupling between two people can produce spontaneous interpersonal postural coordination and change their intrapersonal postural coordination involved in the control of stance. We examined the front-to-back head displacements of participants and the angular motion of their hip and…

  20. Firing membranes

    NARCIS (Netherlands)

    Kappert, Emiel Jan

    2015-01-01

    Thermal processing is commonly employed to alter the chemistry and microstructure of membrane layers. It can shape, strengthen, and give functionality to a membrane. A good understanding of the processes taking place during the thermal processing of a membrane material allows for optimization and tu

  1. Care Coordination Practices among Illinois Pediatricians and Early Intervention Service Coordinators

    Science.gov (United States)

    Baxter, Marissa

    2015-01-01

    Over the course of the past three decades, largely due to advances in technology, there has been growth in the fields of early intervention (EI) and pediatrics for infants/toddlers with special health care needs (SHCN). This growth has also brought about a change in the relationship between pediatricians and EI service coordinators, creating an…

  2. An Adaptable Spectrin/Ankyrin-Based Mechanism for Long-Range Organization of Plasma Membranes in Vertebrate Tissues.

    Science.gov (United States)

    Bennett, Vann; Lorenzo, Damaris N

    2016-01-01

    Ankyrins are membrane-associated proteins that together with their spectrin partners are responsible for micron-scale organization of vertebrate plasma membranes, including those of erythrocytes, excitable membranes of neurons and heart, lateral membrane domains of columnar epithelial cells, and striated muscle. Ankyrins coordinate functionally related membrane transporters and cell adhesion proteins (15 protein families identified so far) within plasma membrane compartments through independently evolved interactions of intrinsically disordered sequences with a highly conserved peptide-binding groove formed by the ANK repeat solenoid. Ankyrins are coupled to spectrins, which are elongated organelle-sized proteins that form mechanically resilient arrays through cross-linking by specialized actin filaments. In addition to protein interactions, cellular targeting and assembly of spectrin/ankyrin domains also critically depend on palmitoylation of ankyrin-G by aspartate-histidine-histidine-cysteine 5/8 palmitoyltransferases, as well as interaction of beta-2 spectrin with phosphoinositide lipids. These lipid-dependent spectrin/ankyrin domains are not static but are locally dynamic and determine membrane identity through opposing endocytosis of bulk lipids as well as specific proteins. A partnership between spectrin, ankyrin, and cell adhesion molecules first emerged in bilaterians over 500 million years ago. Ankyrin and spectrin may have been recruited to plasma membranes from more ancient roles in organelle transport. The basic bilaterian spectrin-ankyrin toolkit markedly expanded in vertebrates through gene duplications combined with variation in unstructured intramolecular regulatory sequences as well as independent evolution of ankyrin-binding activity by ion transporters involved in action potentials and calcium homeostasis. In addition, giant vertebrate ankyrins with specialized roles in axons acquired new coding sequences by exon shuffling. We speculate that

  3. Oligodendroglial membrane dynamics in relation to myelin biogenesis

    NARCIS (Netherlands)

    Ozgen, Hande; Baron, Wia; Hoekstra, Dick; Kahya, Nicoletta

    2016-01-01

    In the central nervous system, oligodendrocytes synthesize a specialized membrane, the myelin membrane, which enwraps the axons in a multilamellar fashion to provide fast action potential conduction and to ensure axonal integrity. When compared to other membranes, the composition of myelin membranes

  4. Membrane Biophysics

    CERN Document Server

    Ashrafuzzaman, Mohammad

    2013-01-01

    Physics, mathematics and chemistry all play a vital role in understanding the true nature and functioning of biological membranes, key elements of living processes. Besides simple spectroscopic observations and electrical measurements of membranes we address in this book the phenomena of coexistence and independent existence of different membrane components using various theoretical approaches. This treatment will be helpful for readers who want to understand biological processes by applying both simple observations and fundamental scientific analysis. It provides a deep understanding of the causes and effects of processes inside membranes, and will thus eventually open new doors for high-level pharmaceutical approaches towards fighting membrane- and cell-related diseases.

  5. Spatio-temporal Remodeling of Functional Membrane Microdomains Organizes the Signaling Networks of a Bacterium

    NARCIS (Netherlands)

    Schneider, Johannes; Klein, Teresa; Mielich-Süss, Benjamin; Koch, Gudrun; Franke, Christian; Kuipers, Oscar P; Kovács, Ákos T; Sauer, Markus; Lopez, Daniel

    Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion. It has been proposed that this functional diversity would require a

  6. Uranyl ion coordination

    Science.gov (United States)

    Evans, H.T.

    1963-01-01

    A review of the known crystal structures containing the uranyl ion shows that plane-pentagon coordination is equally as prevalent as plane-square or plane-hexagon. It is suggested that puckered-hexagon configurations of OH - or H2O about the uranyl group will tend to revert to plane-pentagon coordination. The concept of pentagonal coordination is invoked for possible explanations of the complex crystallography of the natural uranyl hydroxides and the unusual behavior of polynuclear ions in hydrolyzed uranyl solutions.

  7. Coordinate System And Coordinate Transformations Based On Wave Nature Of Light

    CERN Document Server

    Yagan, M F

    2006-01-01

    The Classical Coordinate System is geometrical by nature with time being an external variable. Constructing a classical coordinate system employs a point-like signal with infinite speed. In Special Relativity Theory the speed is limited but the signal is a point-like particle (photon). If the oscillatory nature of light is considered, an event in absolute space is to be characterized by three coordinates namely, distance, time and phase. The Galilean transformation equations for space and time coordinates should be complemented by a third equation that accounts for the phase transformation. Wave equation remains invariant under such transformation and kinematical equivalence of inertial reference frames is conserved. Lorentz transforms apply to wave length and wave period of the exchanged light signal in a dynamic set-up.

  8. Coordinating, Scheduling, Processing and Analyzing IYA09

    Science.gov (United States)

    Gipson, John; Behrend, Dirk; Gordon, David; Himwich, Ed; MacMillan, Dan; Titus, Mike; Corey, Brian

    2010-01-01

    The IVS scheduled a special astrometric VLBI session for the International Year of Astronomy 2009 (IYA09) commemorating 400 years of optical astronomy and 40 years of VLBI. The IYA09 session is the most ambitious geodetic session to date in terms of network size, number of sources, and number of observations. We describe the process of designing, coordinating, scheduling, pre-session station checkout, correlating, and analyzing this session.

  9. Magnetic Coordinate Systems

    CERN Document Server

    Laundal, K M

    2016-01-01

    Geospace phenomena such as the aurora, plasma motion, ionospheric currents and associated magnetic field disturbances are highly organized by Earth's main magnetic field. This is due to the fact that the charged particles that comprise space plasma can move almost freely along magnetic field lines, but not across them. For this reason it is sensible to present such phenomena relative to Earth's magnetic field. A large variety of magnetic coordinate systems exist, designed for different purposes and regions, ranging from the magnetopause to the ionosphere. In this paper we review the most common magnetic coordinate systems and describe how they are defined, where they are used, and how to convert between them. The definitions are presented based on the spherical harmonic expansion coefficients of the International Geomagnetic Reference Field (IGRF) and, in some of the coordinate systems, the position of the Sun which we show how to calculate from the time and date. The most detailed coordinate systems take the...

  10. Supercritical Airfoil Coordinates

    Data.gov (United States)

    National Aeronautics and Space Administration — Rectangular Supercritical Wing (Ricketts) - design and measured locations are provided in an Excel file RSW_airfoil_coordinates_ricketts.xls . One sheet is with Non...

  11. Understanding social motor coordination.

    Science.gov (United States)

    Schmidt, R C; Fitzpatrick, Paula; Caron, Robert; Mergeche, Joanna

    2011-10-01

    Recently there has been much interest in social coordination of motor movements, or as it is referred to by some researchers, joint action. This paper reviews the cognitive perspective's common coding/mirror neuron theory of joint action, describes some of its limitations and then presents the behavioral dynamics perspective as an alternative way of understanding social motor coordination. In particular, behavioral dynamics' ability to explain the temporal coordination of interacting individuals is detailed. Two experiments are then described that demonstrate how dynamical processes of synchronization are apparent in the coordination underlying everyday joint actions such as martial art exercises, hand-clapping games, and conversations. The import of this evidence is that emergent dynamic patterns such as synchronization are the behavioral order that any neural substrate supporting joint action (e.g., mirror systems) would have to sustain.

  12. Environmental Compliance Issue Coordination

    Science.gov (United States)

    An order to establish the Department of Energy (DOE) requirements for coordination of significant environmental compliance issues to ensure timely development and consistent application of Departmental environmental policy and guidance

  13. A quadrilateral membrane hybrid stress element with drilling degrees of freedom

    Institute of Scientific and Technical Information of China (English)

    An-Ping Wang

    2012-01-01

    A new kind of quadrilateral assumed stress hybrid membrane element with drilling degrees of freedom and a traction-free inclined side has been developed based on an extended Hellinger-Reissner principle which is established by expanding the essential terms of the assumed stress field as polynomials in the natural coordinates of the element.The homogeneous equilibrium equations are imposed in a variational sense through the internal displacements which are also expanded in the natural coordinates,while the tractionfree conditions along the inclined side are satisfied exactly.The use of such special element in the finite element solution is shown to be highly accurate when only a very coarse element mesh is used for plates with V-shaped rounded notches or inclined sides.

  14. International Specialization

    DEFF Research Database (Denmark)

    Kleindienst, Ingo; Geisler Asmussen, Christian; Hutzschenreuter, Thomas;

    2012-01-01

    Whether and how international diversification and cross-border arbitrage affects firm performance remains one of the major unresolved research questions in the strategy and international business literatures. We propose that knowing how much a firm has internationally diversified tells us very...... little about performance implications, if we do not know, and do not ask, how the firm has diversified. Therefore, building on the two broad arguments of operating flexibility and location-specific commitment, we develop a theoretical framework that focuses on the extent to which a firm's international...... arbitrage strategy is characterized by specialization versus replication and argue that these different strategies may have differential impact on profitability and risk reduction. Developing a sophisticated measure of international specialization and using a unique panel data set of 92 German MNEs to test...

  15. International Specialization

    DEFF Research Database (Denmark)

    Kleindienst, Ingo; Geisler Asmussen, Christian; Hutzschenreuter, Thomas

    2012-01-01

    Whether and how international diversification and cross-border arbitrage affects firm performance remains one of the major unresolved research questions in the strategy and international business literatures. We propose that knowing how much a firm has internationally diversified tells us very...... little about performance implications, if we do not know, and do not ask, how the firm has diversified. Therefore, building on the two broad arguments of operating flexibility and location-specific commitment, we develop a theoretical framework that focuses on the extent to which a firm's international...... arbitrage strategy is characterized by specialization versus replication and argue that these different strategies may have differential impact on profitability and risk reduction. Developing a sophisticated measure of international specialization and using a unique panel data set of 92 German MNEs to test...

  16. [Coordination and donation].

    Science.gov (United States)

    Elizalde, J; Lorente, M

    2006-01-01

    The progressive incorporation of organ transplants as a therapeutic resource resulted in organisational adaptation and overall transplant management, leading to the emergence of the figure of the transplant coordinator in the mid-1980s. In Spain, the National Organisation of Transplants (Organización Nacional de Transplantes - ONT) was created, establishing a system - called the "Spanish model" - based on a network of coordinators at three levels: national, the autonomous community and the hospital. This organisational structure is a point of reference at the world level. The prevalence of the Intensive Medicine specialisation amongst hospital transplant coordinators is remarkable. The majority of organs proceed from brain-dead patients with beating hearts and this requires the infrastructure offered by intensive care units. The functions of the coordinator can be summarised in guaranteeing a synchrony of all the elements and teams that come together in an organisational chain that has come to be called the "process of donation". Schematically, the crucial points that the hospital coordinator develops are the following: - Detection of the potential donor. - Maintenance of the donor. - Diagnosis of brain death. - Family consent. - Preparation of the hospital logistics. - Helping the relatives. - Direct involvement in the Program of Guarantee of Quality. - Person of reference in any activity related to the transplant. It would be desirable to achieve the creation of transplant coordination teams, with univocal messages, professionalism and a permanent input of the so-called "human factor", which is so necessary and also so close to the transplant world.

  17. Continuous parallel coordinates.

    Science.gov (United States)

    Heinrich, Julian; Weiskopf, Daniel

    2009-01-01

    Typical scientific data is represented on a grid with appropriate interpolation or approximation schemes,defined on a continuous domain. The visualization of such data in parallel coordinates may reveal patterns latently contained in the data and thus can improve the understanding of multidimensional relations. In this paper, we adopt the concept of continuous scatterplots for the visualization of spatially continuous input data to derive a density model for parallel coordinates. Based on the point-line duality between scatterplots and parallel coordinates, we propose a mathematical model that maps density from a continuous scatterplot to parallel coordinates and present different algorithms for both numerical and analytical computation of the resulting density field. In addition, we show how the 2-D model can be used to successively construct continuous parallel coordinates with an arbitrary number of dimensions. Since continuous parallel coordinates interpolate data values within grid cells, a scalable and dense visualization is achieved, which will be demonstrated for typical multi-variate scientific data.

  18. Magnetic Coordinate Systems

    Science.gov (United States)

    Laundal, K. M.; Richmond, A. D.

    2017-03-01

    Geospace phenomena such as the aurora, plasma motion, ionospheric currents and associated magnetic field disturbances are highly organized by Earth's main magnetic field. This is due to the fact that the charged particles that comprise space plasma can move almost freely along magnetic field lines, but not across them. For this reason it is sensible to present such phenomena relative to Earth's magnetic field. A large variety of magnetic coordinate systems exist, designed for different purposes and regions, ranging from the magnetopause to the ionosphere. In this paper we review the most common magnetic coordinate systems and describe how they are defined, where they are used, and how to convert between them. The definitions are presented based on the spherical harmonic expansion coefficients of the International Geomagnetic Reference Field (IGRF) and, in some of the coordinate systems, the position of the Sun which we show how to calculate from the time and date. The most detailed coordinate systems take the full IGRF into account and define magnetic latitude and longitude such that they are constant along field lines. These coordinate systems, which are useful at ionospheric altitudes, are non-orthogonal. We show how to handle vectors and vector calculus in such coordinates, and discuss how systematic errors may appear if this is not done correctly.

  19. Special offer

    CERN Multimedia

    Staff Association

    2010-01-01

    Special offer for members of the Staff Association and their families 10% reduction on all products in the SEPHORA shop (sells perfume, beauty products etc.) in Val Thoiry ALL YEAR ROUND. Plus 20% reduction during their “vente privée”* three or four times a year. Simply present your Staff Association membership card when you make your purchase. * next “vente privée” from 24th to 29th May 2010  

  20. Special offer

    CERN Multimedia

    Staff Association

    2011-01-01

    SPECIAL OFFER FOR OUR MEMBERS Tarif unique Adulte/Enfant Entrée Zone terrestre 19 euros instead of 23 euros Entrée “Zone terrestre + aquatique” 24 euros instead of 31 euros Free for children under 3, with limited access to the attractions. Walibi Rhône-Alpes is open daily from 22 June to 31 August, and every week end from 3 September until 31 October. Closing of the “zone aquatique” 11 September.

  1. Special offer

    CERN Multimedia

    Staff Association

    2011-01-01

    SPECIAL OFFER FOR OUR MEMBERS Tarif unique Adulte/Enfant Entrée Zone terrestre 19 euros instead of 23 euros Entrée “Zone terrestre + aquatique” 24 euros instead of 31 euros Free for children under 3, with limited access to the attractions. Walibi Rhône-Alpes is open daily from 22 June to 31 August, and every week end from 3 September until 31 October. Closing of the “zone aquatique” 11 September.

  2. The spectral world coordinate systems in IRAF/NOAO

    Science.gov (United States)

    Valdes, F.

    1992-01-01

    The world coordinate system (WCS) for dispersion calibrated spectra used in the IRAF/NOAO spectroscopy packages is described. In particular, the image header keywords which define the coordinates in an 'image' pixel array. These keywords appear both as part of the IRAF image structure and map directly to FITS format. The types of spectra include multidimensional images with spectral dispersion as one axis, one dimensional images, and a special 'multispec' format consisting of multiple, semi-independent, one dimensional spectra in two or three dimensional images. The types of coordinate systems include multidimensional linear coordinates with individual keywords and one dimensional linear and nonlinear coordinates for the 'multispec' images stored in IRAF WCS attributes. The nonlinear world coordinate systems include polynomial, spline, sampled table, and look-up table function representations.

  3. Haptic feedback helps bipedal coordination.

    Science.gov (United States)

    Roelofsen, Eefje G J; Bosga, Jurjen; Rosenbaum, David A; Nijhuis-van der Sanden, Maria W G; Hullegie, Wim; van Cingel, Robert; Meulenbroek, Ruud G J

    2016-10-01

    The present study investigated whether special haptic or visual feedback would facilitate the coordination of in-phase, cyclical feet movements of different amplitudes. Seventeen healthy participants sat with their feet on sliding panels that were moved externally over the same or different amplitudes. The participants were asked to generate simultaneous knee flexion-extension movements, or to let their feet be dragged, resulting in reference foot displacements of 150 mm and experimental foot displacements of 150, 120, or 90 mm. Four types of feedback were given: (1) special haptic feedback, involving actively following the motions of the sliders manipulated by two confederates, (2) haptic feedback resulting from passive motion, (3) veridical visual feedback, and (4) enhanced visual feedback. Both with respect to amplitude assimilation effects, correlations and standard deviation of relative phase, the results showed that enhanced visual feedback did not facilitate bipedal independence, but haptic feedback with active movement did. Implications of the findings for movement rehabilitation contexts are discussed.

  4. Physics of biological membranes

    Science.gov (United States)

    Mouritsen, Ole G.

    The biological membrane is a complex system consisting of an aqueous biomolecular planar aggregate of predominantly lipid and protein molecules. At physiological temperatures, the membrane may be considered a thin (˜50Å) slab of anisotropic fluid characterized by a high lateral mobility of the various molecular components. A substantial fraction of biological activity takes place in association with membranes. As a very lively piece of condensed matter, the biological membrane is a challenging research topic for both the experimental and theoretical physicists who are facing a number of fundamental physical problems including molecular self-organization, macromolecular structure and dynamics, inter-macromolecular interactions, structure-function relationships, transport of energy and matter, and interfacial forces. This paper will present a brief review of recent theoretical and experimental progress on such problems, with special emphasis on lipid bilayer structure and dynamics, lipid phase transitions, lipid-protein and lipid-cholesterol interactions, intermembrane forces, and the physical constraints imposed on biomembrane function and evolution. The paper advocates the dual point of view that there are a number of interesting physics problems in membranology and, at the same time, that the physical properties of biomembranes are important regulators of membrane function.

  5. The plasma membrane: Penultimate regulator of ADAM sheddase function.

    Science.gov (United States)

    Reiss, Karina; Bhakdi, Sucharit

    2017-11-01

    ADAM10 and ADAM17 are the best characterized members of the ADAM (A Disintegrin and Metalloproteinase) - family of transmembrane proteases. Both are involved diverse physiological and pathophysiological processes. ADAMs are known to be regulated by posttranslational mechanisms. However, emerging evidence indicates that the plasma membrane with its unique dynamic properties may additionally play an important role in controlling sheddase function. Membrane events that could contribute to regulation of ADAM-function are summarized. Surface expression of peptidolytic activity should be differentiated from ADAM-sheddase function since the latter additionally requires that the protease finds its substrate in the lipid bilayer. We propose that this is achieved through horizontal and vertical reorganization of membrane nanoarchitecture coordinately occurring at the sites of sheddase activation. Reshuffling of nanodomains thereby guides traffic of enzyme and substrate to each other. For ADAM17 phosphatidylserine exposure is required to then induce its shedding function. The novel concept that physicochemical properties of the lipid bilayer govern the action of ADAM-proteases may be extendable to other functional proteins that act at the cell surface. This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John. Copyright © 2017. Published by Elsevier B.V.

  6. Transcriptional coordination of synaptogenesis and neurotransmitter signaling.

    Science.gov (United States)

    Kratsios, Paschalis; Pinan-Lucarré, Bérangère; Kerk, Sze Yen; Weinreb, Alexis; Bessereau, Jean-Louis; Hobert, Oliver

    2015-05-18

    During nervous system development, postmitotic neurons face the challenge of generating and structurally organizing specific synapses with appropriate synaptic partners. An important unexplored question is whether the process of synaptogenesis is coordinated with the adoption of specific signaling properties of a neuron. Such signaling properties are defined by the neurotransmitter system that a neuron uses to communicate with postsynaptic partners, the neurotransmitter receptor type used to receive input from presynaptic neurons, and, potentially, other sensory receptors that activate a neuron. Elucidating the mechanisms that coordinate synaptogenesis, neuronal activation, and neurotransmitter signaling in a postmitotic neuron represents one key approach to understanding how neurons develop as functional units. Using the SAB class of Caenorhabditis elegans motor neurons as a model system, we show here that the phylogenetically conserved COE-type transcription factor UNC-3 is required for synaptogenesis. UNC-3 directly controls the expression of the ADAMTS-like protein MADD-4/Punctin, a presynaptically secreted synapse-organizing molecule that clusters postsynaptic receptors. UNC-3 also controls the assembly of presynaptic specializations and ensures the coordinated expression of enzymes and transporters that define the cholinergic neurotransmitter identity of the SAB neurons. Furthermore, synaptic output properties of the SAB neurons are coordinated with neuronal activation and synaptic input, as evidenced by UNC-3 also regulating the expression of ionotropic neurotransmitter receptors and putative stretch receptors. Our study shows how synaptogenesis and distinct, function-defining signaling features of a postmitotic neuron are hardwired together through coordinated transcriptional control.

  7. Activation of interfacial enzymes at membrane surfaces

    DEFF Research Database (Denmark)

    Mouritsen, Ole G.; Andresen, Thomas Lars; Halperin, Avi;

    2006-01-01

    A host of water-soluble enzymes are active at membrane surfaces and in association with membranes. Some of these enzymes are involved in signalling and in modification and remodelling of the membranes. A special class of enzymes, the phospholipases, and in particular secretory phospholipase A2 (s......PLA2), are only activated at the interface between water and membrane surfaces, where they lead to a break-down of the lipid molecules into lysolipids and free fatty acids. The activation is critically dependent on the physical properties of the lipid-membrane substrate. A topical review is given...

  8. Special Photoconverter

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A special device with photocurrent amplification function is reported. The device with long base region structure consists of dual-route photodetectors and their amplifier. Two photodetectors with a space of 50μm are precisely located in this device. The device with current sensitivity of S≥15A/lm,static state current transmission coefficient of hFE≥5000, single-route dark current of ID≥1μA, high frequency current transmission coefficient modulus of |hfe|≥1 at 400MHz is obtained. At present, the device has been tried out in some inertia systems.

  9. Special offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions. TPG: reduced rates on annual transport passes for active and retired staff. Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret. FNAC: 5% reduction on FNAC vouchers. For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  10. Special Offers

    CERN Multimedia

    Association du personnel

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions. TPG: reduced rates on annual transport passes for active and retired staff. Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret. Walibi: reduced prices for children and adults at this French attraction park in Les Avenières. FNAC: 5% reduction on FNAC vouchers. For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  11. Special offer

    CERN Multimedia

    Staff Association

    2011-01-01

    OFFRE SPECIALE POUR NOS MEMBRES Les vendredis 29 juillet, 5 et 12 août, Aquaparc fermera ses portes exceptionnellement à 22h00. Pour ces évènements, des tarifs défiant toute concurrence vous sont proposés. Au programme : Clown spécialiste de la sculpture de ballons de 16h00 à 21h00 Ambiance Salsa avec danseurs professionnel : Démonstration et Cours de Salsa. Les tarifs : Pour une entrée à partir de 15h00 : Enfant : CHF 22.- Adulte : CHF 26.-  

  12. Characterization of membrane protein trafficking and cellular signaling at the primary cilium

    DEFF Research Database (Denmark)

    Mogensen, Johanne Bay

    , diabetes and tumorigenesis. A specialized gate at the proximal end of the cilium, the transition zone, maintains the specific ciliary protein composition as well as a specialized membrane lipid structure. This dissertation includes two reviews on ciliary signaling (articles I and II) as well as two......Primary cilia are microtubule-based, non-motile, sensory organelles emerging in a single copy from the surface of most quiescent cells in vertebrates. They emanate from the centrosomal mother centriole and are assembled and maintained by a bidirectional transport process termed intraflagellar...... transport. Specific receptors, ion channels and downstream signaling components are localized along the cilium-centrosome axis, enabling the cilium to function as a hot spot for the balanced coordination of multiple signaling pathways to control cell cycle entry, differentiation and migration during...

  13. Coordinating Interactions: The Event Coordination Notation

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    on a much more technical level. The Event Coordination Notation (ECNO) allows modelling the behaviour of an application on a high level of abstraction that is closer to the application’s domain than to the software realizing it. Still, these models contain all necessary details for actually executing...... implementation of ECNO, which consists of a modelling environment based on Eclipse and the Eclipse Modeling Framework (EMF) and an execution engine, which fully supports all the concepts and features of ECNO discussed in this technical report. All the examples are based on EMF, but the ECNO Engine can be used......The purpose of a domain model is to concisely capture the concepts of an application’s domain, and their relation among each other. Even though the main purpose of domain models is not on implementing the application, major parts of an application can be generated from the application’s domain...

  14. On sector magnets or transverse electromagnetic fields in cylindrical coordinates

    CERN Document Server

    Zolkin, Timofey

    2016-01-01

    The Laplace's equations for the scalar and vector potentials describing electric or magnetic fields in cylindrical coordinates with translational invariance along azimuthal coordinate are considered. The series of special functions which, when expanded in power series in radial and vertical coordinates, in lowest order replicate the harmonic homogeneous polynomials of two variables are found. These functions are based on radial harmonics found by Edwin~M.~McMillan in his more-than-40-years "forgotten" article, which will be discussed. In addition to McMillan's harmonics, second family of adjoint radial harmonics is introduced, in order to provide symmetric description between electric and magnetic fields and to describe fields and potentials in terms of same special functions. Formulas to relate any transverse fields specified by the coefficients in the power series expansion in radial or vertical planes in cylindrical coordinates with the set of new functions are provided. This result is no doubt important f...

  15. 77 FR 3269 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Data...

    Science.gov (United States)

    2012-01-23

    ... Prevention (CDC) Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Data Coordinating Center for Autism and Other Developmental Disabilities Research and Epidemiologic Studies,...

  16. Quantifying linguistic coordination

    DEFF Research Database (Denmark)

    Fusaroli, Riccardo; Tylén, Kristian

    ). We employ nominal recurrence analysis (Orsucci et al 2005, Dale et al 2011) on the decision-making conversations between the participants. We report strong correlations between various indexes of recurrence and collective performance. We argue this method allows us to quantify the qualities......Language has been defined as a social coordination device (Clark 1996) enabling innovative modalities of joint action. However, the exact coordinative dynamics over time and their effects are still insufficiently investigated and quantified. Relying on the data produced in a collective decision...

  17. Introduction to Coordination Chemistry

    CERN Document Server

    Lawrance, Geoffrey Alan

    2010-01-01

    Introduction to Coordination Chemistry examines and explains how metals and molecules that bind as ligands interact, and the consequences of this assembly process. This book describes the chemical and physical properties and behavior of the complex assemblies that form, and applications that may arise as a result of these properties. Coordination complexes are an important but often hidden part of our world?even part of us?and what they do is probed in this book. This book distills the essence of this topic for undergraduate students and for research scientists.

  18. Coordinate Standard Measurement Development

    Energy Technology Data Exchange (ETDEWEB)

    Hanshaw, R.A.

    2000-02-18

    A Shelton Precision Interferometer Base, which is used for calibration of coordinate standards, was improved through hardware replacement, software geometry error correction, and reduction of vibration effects. Substantial increases in resolution and reliability, as well as reduction in sampling time, were achieved through hardware replacement; vibration effects were reduced substantially through modification of the machine component dampening and software routines; and the majority of the machine's geometry error was corrected through software geometry error correction. Because of these modifications, the uncertainty of coordinate standards calibrated on this device has been reduced dramatically.

  19. PT Metamaterials via Complex-Coordinate Transformation Optics

    CERN Document Server

    Castaldi, Giuseppe; Galdi, Vincenzo; Alu', Andrea; Engheta, Nader

    2012-01-01

    We extend the transformation-optics paradigm to a complex spatial coordinate domain, in order to deal with electromagnetic metamaterials characterized by balanced loss and gain, giving special emphasis to parity-time (PT) symmetry metamaterials. We apply this general theory to complex-source-point radiation and unidirectional invisibility, illustrating the capability and potentials of our approach in terms of systematic design, analytical modeling and physical insights into complex-coordinate wave-objects and resonant states.

  20. Coordination failure caused by sunspots

    DEFF Research Database (Denmark)

    Beugnot, Julie; Gürgüç, Zeynep; Øvlisen, Frederik Roose

    2012-01-01

    In a coordination game with Pareto-ranked equilibria, we study whether a sunspot can lead to either coordination on an inferior equilibrium (mis-coordination) or to out-of equilibrium behavior (dis-coordination). While much of the literature searches for mechanisms to attain coordination...... on the efficient equilibrium, we consider sunspots as a potential reason for coordination failure. We conduct an experiment with a three player 2x2x2 game in which coordination on the efficient equilibrium is easy and should normally occur. In the control session, we find almost perfect coordination on the payoff......-dominant equilibrium, but in the sunspot treatment, dis-coordination is frequent. Sunspots lead to significant inefficiency, and we conclude that sunspots can indeed cause coordination failure....

  1. Special Offers

    CERN Multimedia

    Association du personnel

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions.     TPG: reduced rates on annual transport passes for active and retired staff.     Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret.     Walibi: reduced prices for children and adults at this French attraction park in Les Avenières.       FNAC: 5% reduction on FNAC vouchers.       For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  2. Special Offers

    CERN Multimedia

    Staff Association

    2011-01-01

    Are you a member of the Staff Association? Did you know that as a member you can benefit from the following special offers: BCGE (Banque Cantonale de Genève): personalized banking solutions with preferential conditions.     TPG: reduced rates on annual transport passes for all active and retired staff.     Aquaparc: reduced ticket prices for children and adults at this Swiss waterpark in Le Bouveret.     Walibi: reduced prices for children and adults at this French attraction park in Les Avenières.       FNAC: 5% reduction on FNAC vouchers.       For more information about all these offers, please consult our web site: http://association.web.cern.ch/association/en/OtherActivities/Offers.html

  3. Special convoy

    CERN Multimedia

    TS-IC Group

    2007-01-01

    A special wide-load convoy will affect traffic between Hall 180 (Meyrin site) and Point 1 (ATLAS) on Tuesday 29 May. The following measures will be in place: Partial closure of Route Arago and Route Einstein between 9.00 a.m. and 12 midday, depending on the rate at which the convoy advances. Closure of Route Einstein between 12 and 2.00 p.m. between Building 104 and Route Veksler (see diagram). Closure of Entrance B in both directions between 12 and 2.30 p.m. Please use Entrance A. For safety reasons, cyclists and pedestrians will not be allowed to ride or walk alongside the convoy. Please comply with the instructions given by the convoy officers. TS-IC Group (tel : 160319 - 163012)

  4. Coordinating Work with Groupware

    DEFF Research Database (Denmark)

    Pors, Jens Kaaber; Simonsen, Jesper

    2003-01-01

    One important goal of employing groupware is to make possible complex collaboration between geographically distributed groups. This requires a dual transformation of both technology and work practice. The challenge is to re­duce the complexity of the coordination work by successfully inte­grating...

  5. Rockin' Readers Coordinator Handbook.

    Science.gov (United States)

    Alachua County Schools, Gainesville, FL.

    This coordinator's handbook describes the "Rockin' Readers" program, in which senior-citizen volunteers are matched with specifically targeted at-risk children (usually of kindergarten age or slightly older) in Alachua County, Florida, who tested below their peer group in language development and reading readiness skills. The handbook…

  6. Explicit Spin Coordinates

    CERN Document Server

    Hunter, G; Hunter, Geoffrey; Schlifer, Ian

    2005-01-01

    The recently established existence of spherical harmonic functions, $Y_\\ell^{m}(\\theta,\\phi)$ for half-odd-integer values of $\\ell$ and $m$, allows for the introduction into quantum chemistry of explicit electron spin-coordinates; i.e. spherical polar angles $\\theta_s, \\phi_s$, that specify the orientation of the spin angular momentum vector in space. In this coordinate representation the spin angular momentum operators, $S^2, S_z$, are represented by the usual differential operators in spherical polar coordinates (commonly used for $L^2, L_z$), and their electron-spin eigenfunctions are $\\sqrt{\\sin\\theta_s} \\exp(\\pm\\phi_s/2)$. This eigenfunction representation has the pedagogical advantage over the abstract spin eigenfunctions, $\\alpha, \\beta,$ that ``integration over spin coordinates'' is a true integration (over the angles $\\theta_s, \\phi_s$). In addition they facilitate construction of many electron wavefunctions in which the electron spins are neither parallel nor antiparallel, but inclined at an interme...

  7. Equilibria with Coordination Failures

    NARCIS (Netherlands)

    Herings, P.J.J.; van der Laan, G.; Talman, A.J.J.

    2004-01-01

    This paper extends the recent literature on equilibria with coordination failures to arbitrary convex sets of admissible prices.We introduce a new equilibrium concept, called quantity constrained equilibrium (QCE), giving a uni.ed treatment to all cases considered in the literature so far.At a QCE

  8. Block coordination copolymers

    Science.gov (United States)

    Koh, Kyoung Moo; Wong-Foy, Antek G; Matzger, Adam J; Benin, Annabelle I; Willis, Richard R

    2012-11-13

    The present invention provides compositions of crystalline coordination copolymers wherein multiple organic molecules are assembled to produce porous framework materials with layered or core-shell structures. These materials are synthesized by sequential growth techniques such as the seed growth technique. In addition, the invention provides a simple procedure for controlling functionality.

  9. Bioelectrochemistry II membrane phenomena

    CERN Document Server

    Blank, M

    1987-01-01

    This book contains the lectures of the second course devoted to bioelectro­ chemistry, held within the framework of the International School of Biophysics. In this course another very large field of bioelectrochemistry, i. e. the field of Membrane Phenomena, was considered, which itself consists of several different, but yet related subfields. Here again, it can be easily stated that it is impossible to give a complete and detailed picture of all membrane phenomena of biological interest in a short course of about one and half week. Therefore the same philosophy, as the one of the first course, was followed, to select a series of lectures at postgraduate level, giving a synthesis of several membrane phenomena chosen among the most'important ones. These lectures should show the large variety of membrane-regulated events occurring in living bodies, and serve as sound interdisciplinary basis to start a special­ ized study of biological phenomena, for which the investigation using the dual approach, physico-che...

  10. Dense-cored vesicles, smooth endoplasmic reticulum, and mitochondria are closely associated with non-specialized parts of plasma membrane of nerve terminals: implications for exocytosis and calcium buffering by intraterminal organelles.

    Science.gov (United States)

    Lysakowski, A; Figueras, H; Price, S D; Peng, Y Y

    1999-01-18

    To determine whether there are anatomical correlates for intraterminal Ca2+ stores to regulate exocytosis of dense-cored vesicles (DCVs) and whether these stores can modulate exocytosis of synaptic vesicles, we studied the spatial distributions of DCVs, smooth endoplasmic reticulum (SER), and mitochondria in 19 serially reconstructed nerve terminals in bullfrog sympathetic ganglia. On average, each bouton had three active zones, 214 DCVs, 26 SER fragments (SERFs), and eight mitochondria. DCVs, SERFs and mitochondria were located, on average, 690, 624, and 526 nm, respectively, away from active zones. Virtually no DCVs were within "docking" (i.e., similar to those for exocytosis of synaptic vesicles. Because there were virtually no SERFs or mitochondria within 50 nm of any active zone, Ca2+ modulation by these organelles is unlikely to affect ACh release evoked by a single action potential. In contrast, 30% of DCVs and 40% of SERFs were located within 50 nm of the nonspecialized regions of the plasma membrane. Because each bouton had at least one SERF within 50 nm of the plasma membrane and most of these SERFs had DCVs, but not mitochondria, near them, it is possible for Ca2+ release from the SER to provide the Ca2+ necessary for DCV exocytosis. The fact that 60% of the mitochondria had some part within 50 nm of the plasma membrane means that it is possible for mitochondrial Ca2+ buffering to affect DCV exocytosis.

  11. Evaluation of freshmen coordination abilities on practical training in gymnastics

    Directory of Open Access Journals (Sweden)

    Tereschenko I.A.

    2013-06-01

    Full Text Available Measured coordination abilities (baseline to the static and dynamic equilibrium of the body, the space-time orientation on the support and in unsupported position, proprioception sense, vestibular stability, vestibular sensitivity, coordination limbs symmetrical and asymmetrical. Coordination abilities were also measured under difficult conditions. The study involved 238 students aged 17 - 18 years. Registered a positive trend of improving performance motor tests, development of educational material. Students who specialize in difficult to coordinate sports had significantly better performance. Found that the content of the material work programs of sports and educational disciplines helps improve sensorimotor coordination tasks students. It is noted that the content of the training material is the basis for efficient formation of motor skills and motor skills development of gymnastic exercises. Recommended ways to increase sports and technical and professional skills of students.

  12. Pediatric Care Coordination: Lessons Learned and Future Priorities.

    Science.gov (United States)

    Cady, Rhonda G; Looman, Wendy S; Lindeke, Linda L; LaPlante, Bonnie; Lundeen, Barbara; Seeley, Amanda; Kautto, Mary E

    2015-09-30

    A fundamental component of the medical home model is care coordination. In Minnesota, this model informed design and implementation of the state's health care home (HCH) model, a key element of statewide healthcare reform legislation. Children with medical complexity (CMC) often require care from multiple specialists and community resources. Coordinating this multi-faceted care within the HCH is challenging. This article describes the need for specialized models of care coordination for CMC. Two models of care coordination for CMC were developed to address this challenge. The TeleFamilies Model of Pediatric Care Coordination uses an advanced practice registered nurse care (APRN) coordinator embedded within an established HCH. The PRoSPer Model of Pediatric Care Coordination uses a registered nurse/social worker care coordinator team embedded within a specialty care system. We describe key findings from implementation of these models, and conclude with lessons learned. Replication of the models is encouraged to increase the evidence base for care coordination for the growing population of children with medical complexities.

  13. Special offers

    CERN Multimedia

    Association du personnel

    2012-01-01

    Special discount to the members of the Staff Association Aquaparc Discounted prices on admission of whole day. Children from 5 to 15 years: 26.– CHF instead of 35.– CHF; Adults from 16 years: 32.– CHF instead of 43.– CHF.Tickets on sale to the Staff Association Secretariat. BCGE Account management on salary account and annual subscription to credit cards free of charge. Other benefits on mortgage loan and financial planning. Comédie de Genève 20% off on full price tickets (also available for partner): from 24 to 32 CHF a ticket instead of 30 to 40 CHF depending on the shows. Ezee Suisse 15% off on the range of electric bikes upon presentation of your Staff Association membership card before payment. FNAC 5% discount on gifts card available in four Swiss shops without any restriction. Gifts card on sale to the Staff Association Secretariat. FutureKids 15% off for the Staff Association members who enrol their children of 5 to 16 years old in ...

  14. Indicators of special physical training archers on the stage of special basic training

    Directory of Open Access Journals (Sweden)

    Antonov S.V.

    2012-10-01

    Full Text Available The features of the special physical training of archers are considered from a bow on the stage of the specialized base training. To research 45 sportsmen (24 youths and a 21 girls were brought over from the anchorwomen of sporting schools of Ukraine (Lvov, Kharkov. Testing of leading physical qualities is conducted for archery. It is set that the special physical training of sportsmen is characterized prevailing of displays of power qualities. It is not discovered differences for the displays of co-ordinating capabilities (complex display, feelings of the bow and separate power qualities (force of bow, multiple traction of bow on gender features. It is set that skilled sportsmen do not show the proper level of contiguous development of co-ordinating and power qualities. Recommended for the training process of skilled sportsmen is an increase of volume of exercises with the directed development of co-ordinating capabilities.

  15. Voices of Special Educators in Sweden: A Total-Population Study

    Science.gov (United States)

    Göransson, Kerstin; Lindqvist, Gunilla; Nilholm, Claes

    2015-01-01

    Background: There are two occupational groups in Sweden that are expected to have significant impact on educational work related to children in need of special support. These two groups are special educational needs coordinators (SENCOs) and special education teachers. In this paper, we use the collective name "special educators" to…

  16. Geometry of Membrane Sigma Models

    CERN Document Server

    Vysoky, Jan

    2015-01-01

    String theory still remains one of the promising candidates for a unification of the theory of gravity and quantum field theory. One of its essential parts is relativistic description of moving multi-dimensional objects called membranes (or p-branes) in a curved spacetime. On the classical field theory level, they are described by an action functional extremalising the volume of a manifold swept by a propagating membrane. This and related field theories are collectively called membrane sigma models. Differential geometry is an important mathematical tool in the study of string theory. It turns out that string and membrane backgrounds can be conveniently described using objects defined on a direct sum of tangent and cotangent bundles of the spacetime manifold. Mathematical field studying such object is called generalized geometry. Its integral part is the theory of Leibniz algebroids, vector bundles with a Leibniz algebra bracket on its module of smooth sections. Special cases of Leibniz algebroids are better ...

  17. Membrane solutions to Horava gravity

    CERN Document Server

    Argüelles, Carlos R

    2010-01-01

    We investigated purely gravitational membrane solutions to Ho\\v rava nonrelativistic theory of gravity with detailed balance in $3+1$ dimensions. We find that for arbitrary values of the running parameter $\\lambda>1/3$ two branches of membrane solutions exist, and that in the special case $\\lambda=1$ one of them is degenerate, the lapse function being undetermined. For negative values of the cosmological constant, the solution contains a single membrane sitting at the center of a space, which extends infinitely in the transverse direction approaching a Lifshitz metric. For positive values of the cosmological constant, the solution represents a space that is bounded in the transverse direction, with two parallel membranes hidden behind event horizons sitting at each of the boundaries.

  18. Ceramic Ultrafiltration Membrane from Nanosilica Particles

    Science.gov (United States)

    Wahid, Zarina Abdul; Ramli, Rafindde; Muchtar, Andanastuti; Mohammad, Abd Wahab

    This study attempts to develop asymmetric ceramic membrane filter from nanosilica particles for ultrafiltration (UF) membrane. The alumina tube was used as a support and was coated with SiC which acted as an intermediate layer or microfiltration (MF) layer. The UF membrane was developed using the filtration technique through chemical suspension of the particles. Nanosilica was suspended in HCl acid, iso-propanol and acetone before it was deposited on the alumina tube using a special coating assembly. The membranes were characterised for pore size, thickness and microstructure. This study found that the use of nanoparticles for membrane development could easily control the pore size as well as the thickness of the membrane. The uniformity of the membrane thickness could also be achieved through this filtration technique.

  19. Pointlike Inclusion Interactions in Tubular Membranes

    Science.gov (United States)

    Vahid, Afshin; Idema, Timon

    2016-09-01

    Membrane tubes and tubular networks are ubiquitous in living cells. Inclusions like proteins are vital for both the stability and the dynamics of such networks. These inclusions interact via the curvature deformations they impose on the membrane. We analytically study the resulting membrane mediated interactions in strongly curved tubular membranes. We model inclusions as constraints coupled to the curvature tensor of the membrane tube. First, as special test cases, we analyze the interaction between ring- and rod-shaped inclusions. Using Monte Carlo simulations, we further show how pointlike inclusions interact to form linear aggregates. To minimize the curvature energy of the membrane, inclusions self-assemble into either line- or ringlike patterns. Our results show that the global curvature of the membrane strongly affects the interactions between proteins embedded in it, and can lead to the spontaneous formation of biologically relevant structures.

  20. Global Coordinate System

    Science.gov (United States)

    1985-02-01

    Time in hours at Oh UT is GAST (hours) = GMST + E (41) GAST in radians is GASTo (radians) = GAST (hours) L (42) The angle e required for transforming...inertial coordinates to ECEF is- 6(radians) GASTo + 6.3003880.99 (ti - th) (43) o ~ooUT Mod ( E 27) where St.i - tohLjT = (JD -2.4 106). (JDOE -2.4 x

  1. International Monetary Policy Coordination

    OpenAIRE

    Carlberg, Michael

    2005-01-01

    This paper studies the international coordination of monetary policies in the world economy. It carefully discusses the process of policy competition and the structure of policy cooperation. As to policy competition, the focus is on monetary competition between Europe and America. Similarly, as to policy cooperation, the focus is on monetary cooperation between Europe and America. The spillover effects of monetary policy are negative. The policy targets are price stability and full employment.

  2. Facilitating Group Decision-Making: Facilitator's Subjective Theories on Group Coordination

    Directory of Open Access Journals (Sweden)

    Michaela Kolbe

    2008-10-01

    Full Text Available A key feature of group facilitation is motivating and coordinating people to perform their joint work. This paper focuses on group coordination which is a prerequisite to group effectiveness, especially in complex tasks. Decision-making in groups is a complex task that consequently needs to be coordinated by explicit rather than implicit coordination mechanisms. Based on the embedded definition that explicit coordination does not just happen but is purposely executed by individuals, we argue that individual coordination intentions and mechanisms should be taken into account. Thus far, the subjective perspective of coordination has been neglected in coordination theory, which is understandable given the difficulties in defining and measuring subjective aspects of group facilitation. We therefore conducted focused interviews with eight experts who either worked as senior managers or as experienced group facilitators and analysed their approaches to group coordination using methods of content analysis. Results show that these experts possess sophisticated mental representations of their coordination behaviour. These subjective coordination theories can be organised in terms of coordination schemes in which coordination-releasing situations are facilitated by special coordination mechanisms that, in turn, lead to the perception of specific consequences. We discuss the importance of these subjective coordination theories for effectively facilitating group decision-making and minimising process losses. URN: urn:nbn:de:0114-fqs0901287

  3. Global coordination: weighted voting

    Directory of Open Access Journals (Sweden)

    Jan-Erik Lane

    2014-03-01

    Full Text Available In order to halt the depletion of global ecological capital, a number of different kinds of meetings between Governments of countries in the world has been scheduled. The need for global coordination of environmental policies has become ever more obvious, supported by more and more evidence of the running down of ecological capital. But there are no formal or binding arrangements in sight, as global environmental coordination suffers from high transaction costs (qualitative voting. The CO2 equivalent emissions, resulting in global warming, are driven by the unstoppable economic expansion in the global market economy, employing mainly fossil fuel generated energy, although at the same time lifting sharply the GDP per capita of several emerging countries. Only global environmental coordination on the successful model of the World Band and the IMF (quantitative voting can stem the rising emissions numbers and stop further environmental degradation. However, the system of weighted voting in the WB and the IMF must be reformed by reducing the excessive voting power disparities, for instance by reducing all member country votes by the cube root expression.

  4. Universal mechatronics coordinator

    Science.gov (United States)

    Muir, Patrick F.

    1999-11-01

    Mechatronic systems incorporate multiple actuators and sensor which must be properly coordinated to achieve the desired system functionality. Many mechatronic systems are designed as one-of-a-kind custom projects without consideration for facilitating future system or alterations and extensions to the current syste. Thus, subsequent changes to the system are slow, different, and costly. It has become apparent that manufacturing processes, and thus the mechatronics which embody them, need to be agile in order to more quickly and easily respond to changing customer demands or market pressures. To achieve agility, both the hardware and software of the system need to be designed such that the creation of new system and the alteration and extension of current system is fast and easy. This paper describes the design of a Universal Mechatronics Coordinator (UMC) which facilitates agile setup and changeover of coordination software for mechatronic systems. The UMC is capable of sequencing continuous and discrete actions that are programmed as stimulus-response pairs, as state machines, or a combination of the two. It facilitates the modular, reusable programing of continuous actions such as servo control algorithms, data collection code, and safety checking routines; and discrete actions such as reporting achieved states, and turning on/off binary devices. The UMC has been applied to the control of a z- theta assembly robot for the Minifactory project and is applicable to a spectrum of widely differing mechatronic systems.

  5. Improving Project Manufacturing Coordination

    Directory of Open Access Journals (Sweden)

    Korpivaara Ville

    2014-09-01

    Full Text Available The objective of this research is to develop firms’ project manufacturing coordination. The development will be made by centralizing the manufacturing information flows in one system. To be able to centralize information, a deep user need assessment is required. After user needs have been identified, the existing system will be developed to match these needs. The theoretical background is achieved through exploring the literature of project manufacturing, development project success factors and different frameworks and tools for development project execution. The focus of this research is rather in customer need assessment than in system’s technical expertise. To ensure the deep understanding of customer needs this study is executed by action research method. As a result of this research the information system for project manufacturing coordination was developed to respond revealed needs of the stakeholders. The new system improves the quality of the manufacturing information, eliminates waste in manufacturing coordination processes and offers a better visibility to the project manufacturing. Hence it provides a solid base for the further development of project manufacturing.

  6. 78 FR 46860 - Proposed Waiver and Extension of the Project Period for the Technical Assistance Coordination Center

    Science.gov (United States)

    2013-08-02

    ... 5, 2008, the Department published a notice in the Federal Register (73 FR 32016) inviting... Coordination Center AGENCY: Office of Special Education Programs (OSEP), Office of Special Education and... Coordination Center to receive funding from October 1, 2013, through September 30, 2014. DATES: We must...

  7. The formation of endosymbiotic membrane compartments: membrane identity markers and the regulation of vesicle trafficking

    NARCIS (Netherlands)

    Ivanov, S.

    2012-01-01

    In symbiosis of plants and arbuscular mycorrhizal fungi as well as in rhizobium-legume symbiosis the microbes are hosted intracellularly, inside specialized membrane compartments of the host. These membrane compartments are morphologically different but similar in function, since they control the ex

  8. Coordinated planning for science in communist europe.

    Science.gov (United States)

    Jordan, L F

    1967-02-17

    The Council is not engaged in the supranational formulation of policy and planning on scientific research and technology, but has made considerable progress in coordinating research policies and plans on a limited number of scientific and technical problems of priority interest and of common concern to all members. The establishment of national science-planning institutions in CEMA countries and the adoption of a uniform approach to the formulation of national science policies and plans must be considered basic procedures for achieving international coordination of their efforts. The creation of organizational units within CEMA to deal specifically with the coordination of science policies and plans represents a strengthening of the institutional framework that is necessary for coordination of an internationally cooperative effort in research and technology. Moreover, CEMA's 1-year plan for science and technology has probably been of considerable value as a pilot project for the formulation of the research plan for 1966-70. The delineation of a limited number of important scientific and technical problems of common interest to the members, and the allocation of research projects to a country having the highest capability to conduct them, hold considerable promise for financial savings and for improved utilization of the limited scientific manpower and research facilities of the CEMA countries. While all these measures are significant in CEMA's attempt to improve coordination of science policy and planning, only time will enable true assessment of their effectiveness. The Council's scheme for the specialization of labor in research and technology has met and will undoubtedly continue to meet, considerable opposition by various segments of the scientific communities because of deep-rooted and long-standing national prejudices, and reluctance of vested interests to give up research activities in which they are interested and to which their professional futures are

  9. Symmetric two-coordinate photodiode

    Directory of Open Access Journals (Sweden)

    Dobrovolskiy Yu. G.

    2008-12-01

    Full Text Available The two-coordinate photodiode is developed and explored on the longitudinal photoeffect, which allows to get the coordinate descriptions symmetric on the steepness and longitudinal resistance great exactness. It was shown, that the best type of the coordinate description is observed in the case of scanning by the optical probe on the central part of the photosensitive element. The ways of improvement of steepness and linear of its coordinate description were analyzed.

  10. Invariant Manifolds and Collective Coordinates

    CERN Document Server

    Papenbrock, T

    2001-01-01

    We introduce suitable coordinate systems for interacting many-body systems with invariant manifolds. These are Cartesian in coordinate and momentum space and chosen such that several components are identically zero for motion on the invariant manifold. In this sense these coordinates are collective. We make a connection to Zickendraht's collective coordinates and present certain configurations of few-body systems where rotations and vibrations decouple from single-particle motion. These configurations do not depend on details of the interaction.

  11. Focus on membrane differentiation and membrane domains in the prokaryotic cell.

    Science.gov (United States)

    Boekema, Egbert J; Scheffers, Dirk-Jan; van Bezouwen, Laura S; Bolhuis, Henk; Folea, I Mihaela

    2013-01-01

    A summary is presented of membrane differentiation in the prokaryotic cell, with an emphasis on the organization of proteins in the plasma/cell membrane. Many species belonging to the Eubacteria and Archaea have special membrane domains and/or membrane proliferation, which are vital for different cellular processes. Typical membrane domains are found in bacteria where a specific membrane protein is abundantly expressed. Lipid rafts form another example. Despite the rareness of conventional organelles as found in eukaryotes, some bacteria are known to have an intricate internal cell membrane organization. Membrane proliferation can be divided into curvature and invaginations which can lead to internal compartmentalization. This study discusses some of the clearest examples of bacteria with such domains and internal membranes. The need for membrane specialization is highest among the heterogeneous group of bacteria which harvest light energy, such as photosynthetic bacteria and halophilic archaea. Most of the highly specialized membranes and domains, such as the purple membrane, chromatophore and chlorosome, are found in these autotrophic organisms. Otherwise the need for membrane differentiation is lower and variable, except for those structures involved in cell division. Microscopy techniques have given essential insight into bacterial membrane morphology. As microscopy will further contribute to the unraveling of membrane organization in the years to come, past and present technology in electron microscopy and light microscopy is discussed. Electron microscopy was the first to unravel bacterial morphology because it can directly visualize membranes with inserted proteins, which no other technique can do. Electron microscopy techniques developed in the 1950s and perfected in the following decades involve the thin sectioning and freeze fractioning of cells. Several studies from the golden age of these techniques show amazing examples of cell membrane morphology

  12. Coordination Processes in International Organisations

    DEFF Research Database (Denmark)

    Nedergaard, Peter

    2008-01-01

    to coordinate relatively elaborate agreements due to the strength of its coordination as far as professional or technical and political activities (excepting the ILO budget) are concerned. In other more clear-cut or 'simple' policy areas such as the ILO budget, the EU coordination is weak: this contrast...

  13. 5 CFR 9901.105 - OPM coordination and approval.

    Science.gov (United States)

    2010-01-01

    ... intended as an internal DoD/OPM matter to recognize the Secretary's special authority to direct the... applicable premium pay limitations, as authorized under § 9901.362(a)(2); (3) Determining pay bands for which... categories under § 9901.362(i)(3). (d) When a matter requiring OPM coordination is submitted to the...

  14. The problem of organization of a coastal coordinating computer center

    Science.gov (United States)

    Dyubkin, I. A.; Lodkin, I. I.

    1974-01-01

    The fundamental principles of the operation of a coastal coordinating and computing center under conditions of automation are presented. Special attention is devoted to the work of Coastal Computer Center of the Arctic and Antarctic Scientific Research Institute. This center generalizes from data collected in expeditions and also from observations made at polar stations.

  15. 42 CFR 438.208 - Coordination and continuity of care.

    Science.gov (United States)

    2010-10-01

    ... Section 438.208 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Improvement Access Standards § 438.208 Coordination and continuity of care. (a) Basic requirement—(1) General... individual with special health care needs, as specified in paragraph (c) of this section. (3) Exception for...

  16. Work Coordination Engine

    Science.gov (United States)

    Zendejas, Silvino; Bui, Tung; Bui, Bach; Malhotra, Shantanu; Chen, Fannie; Kim, Rachel; Allen, Christopher; Luong, Ivy; Chang, George; Sadaqathulla, Syed

    2009-01-01

    The Work Coordination Engine (WCE) is a Java application integrated into the Service Management Database (SMDB), which coordinates the dispatching and monitoring of a work order system. WCE de-queues work orders from SMDB and orchestrates the dispatching of work to a registered set of software worker applications distributed over a set of local, or remote, heterogeneous computing systems. WCE monitors the execution of work orders once dispatched, and accepts the results of the work order by storing to the SMDB persistent store. The software leverages the use of a relational database, Java Messaging System (JMS), and Web Services using Simple Object Access Protocol (SOAP) technologies to implement an efficient work-order dispatching mechanism capable of coordinating the work of multiple computer servers on various platforms working concurrently on different, or similar, types of data or algorithmic processing. Existing (legacy) applications can be wrapped with a proxy object so that no changes to the application are needed to make them available for integration into the work order system as "workers." WCE automatically reschedules work orders that fail to be executed by one server to a different server if available. From initiation to completion, the system manages the execution state of work orders and workers via a well-defined set of events, states, and actions. It allows for configurable work-order execution timeouts by work-order type. This innovation eliminates a current processing bottleneck by providing a highly scalable, distributed work-order system used to quickly generate products needed by the Deep Space Network (DSN) to support space flight operations. WCE is driven by asynchronous messages delivered via JMS indicating the availability of new work or workers. It runs completely unattended in support of the lights-out operations concept in the DSN.

  17. Protein selection and export via outer membrane vesicles.

    Science.gov (United States)

    Bonnington, K E; Kuehn, M J

    2014-08-01

    Outer membrane vesicles (OMVs) are constitutively produced by all Gram-negative bacteria. OMVs form when buds from the outer membrane (OM) of cells encapsulate periplasmic material and pinch off from the OM to form spheroid particles approximately 10 to 300nm in diameter. OMVs accomplish a diversity of functional roles yet the OMV's utility is ultimately determined by its unique composition. Inclusion into OMVs may impart a variety of benefits to the protein cargo, including: protection from proteolytic degradation, enhancement of long-distance delivery, specificity in host-cell targeting, modulation of the immune response, coordinated secretion with other bacterial effectors, and/or exposure to a unique function-promoting environment. Many enriched OMV-associated components are virulence factors, aiding in host cell destruction, immune system evasion, host cell invasion, or antibiotic resistance. Although the mechanistic details of how proteins become enriched as OMV cargo remain elusive, recent data on OM biogenesis and relationships between LPS structure and OMV-cargo inclusion rates shed light on potential models for OM organization and consequent OMV budding. In this review, mechanisms based on pre-existing OM microdomains are proposed to explain how cargo may experience differing levels of enrichment in OMVs and degrees of association with OMVs during extracellular export. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Advice for Coordination

    DEFF Research Database (Denmark)

    Hankin, Chris; Nielson, Flemming; Nielson, Hanne Riis

    2008-01-01

    demanding than the closed joinpoints in more traditional aspect oriented languages like AspectJ. The usefulness of our approach is demonstrated by mechanisms for discretionary and mandatory access control policies, as usually expressed by reference monitors, as well as mechanisms for logging actions.......We show how to extend a coordination language with support for aspect oriented programming. The main challenge is how to properly deal with the trapping of actions before the actual data have been bound to the formal parameters. This necessitates dealing with open joinpoints – which is more...

  19. Markov stochasticity coordinates

    Science.gov (United States)

    Eliazar, Iddo

    2017-01-01

    Markov dynamics constitute one of the most fundamental models of random motion between the states of a system of interest. Markov dynamics have diverse applications in many fields of science and engineering, and are particularly applicable in the context of random motion in networks. In this paper we present a two-dimensional gauging method of the randomness of Markov dynamics. The method-termed Markov Stochasticity Coordinates-is established, discussed, and exemplified. Also, the method is tweaked to quantify the stochasticity of the first-passage-times of Markov dynamics, and the socioeconomic equality and mobility in human societies.

  20. Is there a map between Galilean relativity and special relativity?

    OpenAIRE

    Shariati, Ahmad; Jafari, N.

    2014-01-01

    Mandanici has provided a map which he claims to be a two way map between Galilean relativity and special relativity. We argue that this map is simply a curvilinear coordinate system on a subset of the two-dimensional Minkowski space-time, and is not a two way map between 1+1 dimensional Galilean relativity and 1+1 dimensional special relativity.

  1. Primordial membranes

    DEFF Research Database (Denmark)

    Hanczyc, Martin M; Monnard, Pierre-Alain

    2017-01-01

    Cellular membranes, which are self-assembled bilayer structures mainly composed of lipids, proteins and conjugated polysaccharides, are the defining feature of cell physiology. It is likely that the complexity of contemporary cells was preceded by simpler chemical systems or protocells during the...

  2. Robotic membranes

    DEFF Research Database (Denmark)

    Ramsgaard Thomsen, Mette

    2008-01-01

    , Vivisection and Strange Metabolisms, were developed at the Centre for Information Technology and Architecture (CITA) at the Royal Danish Academy of Fine Arts in Copenhagen as a means of engaging intangible digital data with tactile physical material. As robotic membranes, they are a dual examination...

  3. Formation and Regulation of Mitochondrial Membranes

    Directory of Open Access Journals (Sweden)

    Laila Cigana Schenkel

    2014-01-01

    Full Text Available Mitochondrial membrane phospholipids are essential for the mitochondrial architecture, the activity of respiratory proteins, and the transport of proteins into the mitochondria. The accumulation of phospholipids within mitochondria depends on a coordinate synthesis, degradation, and trafficking of phospholipids between the endoplasmic reticulum (ER and mitochondria as well as intramitochondrial lipid trafficking. Several studies highlight the contribution of dietary fatty acids to the remodeling of phospholipids and mitochondrial membrane homeostasis. Understanding the role of phospholipids in the mitochondrial membrane and their metabolism will shed light on the molecular mechanisms involved in the regulation of mitochondrial function and in the mitochondrial-related diseases.

  4. Coordination Processes in International Organisations

    DEFF Research Database (Denmark)

    Nedergaard, Peter

    2008-01-01

    The EU is not a member of the International Labour Organisation (ILO), but relatively elaborate EU coordination takes place anyway. This paper addresses two research questions: 1) How is it possible to evaluate the coordination of the EU in its specific observable configuration in the ILO?, and 2......) To what outcome does this coordination lead and why? Based on an analysis of EU coordination before and during the International Labour Conference in 2005, and on a comparison with coordination processes of the IMEC group, it is found that the Commission and the Presidency act as twin-agents vis...... by the principals. On the other hand, both before and during the Conference, the Member States accept the so-called discursive coordination of the Commission, which seems to be of great (but often neglected) importance. Owing to the organisational set-up in which coordination takes place, the EU is able...

  5. The plant plasma membrane H+-ATPase

    DEFF Research Database (Denmark)

    Ekberg, Kira

      The very high mobility of protons in aqueous solutions demands special features of membrane proton transporters to sustain efficient yet regulated proton transport across biological membranes. By the use of the chemical energy of ATP, plasma-membrane-embedded H+-ATPases extrude protons from cells...... of plants and fungi to generate electrochemical proton gradients. A recently published crystal structure of a plasma membrane H(+)-ATPase contributes to our knowledge about the mechanism of these essential enzymes. Together with biochemical and structural data presented in this thesis we are now able...... to describe the basic molecular components that allow the plasma membrane proton H+-ATPase to carry out proton transport against large membrane potentials. Moreover, a completely new paradigm for post-translational activation of these proteins is presented. The talk will focus on the following themes...

  6. [Germ cell membrane lipids in spermatogenesis].

    Science.gov (United States)

    Wang, Ting; Shi, Xiao; Quan, Song

    2016-05-01

    Spermatogenesis is a complex developmental process in which a diploid progenitor germ cell transforms into highly specialized spermatozoa. During spermatogenesis, membrane remodeling takes place, and cell membrane permeability and liquidity undergo phase-specific changes, which are all associated with the alteration of membrane lipids. Lipids are important components of the germ cell membrane, whose volume and ratio fluctuate in different phases of spermatogenesis. Abnormal lipid metabolism can cause spermatogenic dysfunction and consequently male infertility. Germ cell membrane lipids are mainly composed of cholesterol, phospholipids and glycolipids, which play critical roles in cell adhesion and signal transduction during spermatogenesis. An insight into the correlation of membrane lipids with spermatogenesis helps us to better understand the mechanisms of spermatogenesis and provide new approaches to the diagnosis and treatment of male infertility.

  7. The plant plasma membrane H+-ATPase

    DEFF Research Database (Denmark)

    Ekberg, Kira

      The very high mobility of protons in aqueous solutions demands special features of membrane proton transporters to sustain efficient yet regulated proton transport across biological membranes. By the use of the chemical energy of ATP, plasma-membrane-embedded H+-ATPases extrude protons from cells...... of plants and fungi to generate electrochemical proton gradients. A recently published crystal structure of a plasma membrane H(+)-ATPase contributes to our knowledge about the mechanism of these essential enzymes. Together with biochemical and structural data presented in this thesis we are now able...... to describe the basic molecular components that allow the plasma membrane proton H+-ATPase to carry out proton transport against large membrane potentials. Moreover, a completely new paradigm for post-translational activation of these proteins is presented. The talk will focus on the following themes...

  8. Geomembrane special study. [UMTRA Project

    Energy Technology Data Exchange (ETDEWEB)

    1988-07-01

    The objective of the Geomembrane Special Study was to asses the suitability of geomembranes in Uranium Mill Tailings Remedial Action (UMTRA) Project pile designs. Geomembranes, also called flexible membrane liners, are made of polymer resins and are thermoplastic materials. Part of the special study was to evaluate regulatory compliance and acceptability issues. This study was proposed because of the extensive use of geomembranes in hazardous waste site remedial actions and their accepted use in Resource Conservation and Recovery Act (RCRA) cells as both covers and liners to limit infiltration, or as part of leachate collection systems. This study has reviewed the recent geomembrane literature focusing on: (1) longevity; (2) performance; (3) constructibility; and (4) quality control/quality assurance considerations. In addition to these technical considerations, regulatory compliance and acceptability concerns were also evaluated. This report describes the results of the literature review, including correspondence with manufacturers, resin producers, experts in the field, and long-term major users. 12 refs., 2 tabs.

  9. Cluster algebras in Scattering Amplitudes with special 2D kinematics

    CERN Document Server

    Torres, Marcus A C

    2013-01-01

    We study the cluster algebra of the kinematic configuration space $Conf_n(\\mathbb{P}^3)$ of a n-particle scattering amplitude restricted to the special 2D kinematics. We found that the n-points two loop MHV remainder function found in special 2D kinematics depend on a selection of \\XX-coordinates that are part of a special structure of the cluster algebra related to snake triangulations of polygons. This structure forms a necklace of hypercubes beads in the corresponding Stasheff polytope. Furthermore in $n = 12$, the cluster algebra and the selection of \\XX-coordinates in special 2D kinematics replicates the cluster algebra and the selection of \\XX-coordinates of $n=6$ two loop MHV amplitude in 4D kinematics.

  10. Algorithmically specialized parallel computers

    CERN Document Server

    Snyder, Lawrence; Gannon, Dennis B

    1985-01-01

    Algorithmically Specialized Parallel Computers focuses on the concept and characteristics of an algorithmically specialized computer.This book discusses the algorithmically specialized computers, algorithmic specialization using VLSI, and innovative architectures. The architectures and algorithms for digital signal, speech, and image processing and specialized architectures for numerical computations are also elaborated. Other topics include the model for analyzing generalized inter-processor, pipelined architecture for search tree maintenance, and specialized computer organization for raster

  11. Coordination using Implicit Communication

    CERN Document Server

    Cuff, Paul

    2011-01-01

    We explore a basic noise-free signaling scenario where coordination and communication are naturally merged. A random signal X_1,...,X_n is processed to produce a control signal or action sequence A_1,...,A_n, which is observed and further processed (without access to X_1,...,X_n) to produce a third sequence B_1,...,B_n. The object of interest is the set of empirical joint distributions p(x,a,b) that can be achieved in this setting. We show that H(A) >= I(X;A,B) is the necessary and sufficient condition for achieving p(x,a,b) when no causality constraints are enforced on the encoders. We also give results for various causality constraints. This setting sheds light on the embedding of digital information in analog signals, a concept that is exploited in digital watermarking, steganography, cooperative communication, and strategic play in team games such as bridge.

  12. On Coordinating Collaborative Objects

    CERN Document Server

    Imine, Abdessamad

    2010-01-01

    A collaborative object represents a data type (such as a text document) designed to be shared by a group of dispersed users. The Operational Transformation (OT) is a coordination approach used for supporting optimistic replication for these objects. It allows the users to concurrently update the shared data and exchange their updates in any order since the convergence of all replicas, i.e. the fact that all users view the same data, is ensured in all cases. However, designing algorithms for achieving convergence with the OT approach is a critical and challenging issue. In this paper, we propose a formal compositional method for specifying complex collaborative objects. The most important feature of our method is that designing an OT algorithm for the composed collaborative object can be done by reusing the OT algorithms of component collaborative objects. By using our method, we can start from correct small collaborative objects which are relatively easy to handle and incrementally combine them to build more ...

  13. Coordinating Group report

    Energy Technology Data Exchange (ETDEWEB)

    1994-01-01

    In December 1992, western governors and four federal agencies established a Federal Advisory Committee to Develop On-site Innovative Technologies for Environmental Restoration and Waste Management (the DOIT Committee). The purpose of the Committee is to advise the federal government on ways to improve waste cleanup technology development and the cleanup of federal sites in the West. The Committee directed in January 1993 that information be collected from a wide range of potential stakeholders and that innovative technology candidate projects be identified, organized, set in motion, and evaluated to test new partnerships, regulatory approaches, and technologies which will lead to improve site cleanup. Five working groups were organized, one to develop broad project selection and evaluation criteria and four to focus on specific contaminant problems. A Coordinating Group comprised of working group spokesmen and federal and state representatives, was set up to plan and organize the routine functioning of these working groups. The working groups were charged with defining particular contaminant problems; identifying shortcomings in technology development, stakeholder involvement, regulatory review, and commercialization which impede the resolution of these problems; and identifying candidate sites or technologies which could serve as regional innovative demonstration projects to test new approaches to overcome the shortcomings. This report from the Coordinating Group to the DOIT Committee highlights the key findings and opportunities uncovered by these fact-finding working groups. It provides a basis from which recommendations from the DOIT Committee to the federal government can be made. It also includes observations from two public roundtables, one on commercialization and another on regulatory and institutional barriers impeding technology development and cleanup.

  14. Membrane microdomains, rafts, and detergent-resistant membranes in plants and fungi.

    Science.gov (United States)

    Malinsky, Jan; Opekarová, Miroslava; Grossmann, Guido; Tanner, Widmar

    2013-01-01

    The existence of specialized microdomains in plasma membranes, postulated for almost 25 years, has been popularized by the concept of lipid or membrane rafts. The idea that detergent-resistant membranes are equivalent to lipid rafts, which was generally abandoned after a decade of vigorous data accumulation, contributed to intense discussions about the validity of the raft concept. The existence of membrane microdomains, meanwhile, has been verified by unequivocal independent evidence. This review summarizes the current state of research in plants and fungi with respect to common aspects of both kingdoms. In these organisms, principally immobile microdomains large enough for microscopic detection have been visualized. These microdomains are found in the context of cell-cell interactions (plant symbionts and pathogens), membrane transport, stress, and polarized growth, and the data corroborate at least three mechanisms of formation. As documented in this review, modern methods of visualization of lateral membrane compartments are also able to uncover the functional relevance of membrane microdomains.

  15. Invariant manifolds and collective coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Papenbrock, T. [Centro Internacional de Ciencias, Cuernavaca, Morelos (Mexico); Institute for Nuclear Theory, University of Washington, Seattle, WA (United States); Seligman, T.H. [Centro Internacional de Ciencias, Cuernavaca, Morelos (Mexico); Centro de Ciencias Fisicas, University of Mexico (UNAM), Cuernavaca (Mexico)

    2001-09-14

    We introduce suitable coordinate systems for interacting many-body systems with invariant manifolds. These are Cartesian in coordinate and momentum space and chosen such that several components are identically zero for motion on the invariant manifold. In this sense these coordinates are collective. We make a connection to Zickendraht's collective coordinates and present certain configurations of few-body systems where rotations and vibrations decouple from single-particle motion. These configurations do not depend on details of the interaction. (author)

  16. PAIR MOTOR COORDINATION ACTION IN SPORTSMEN (ON THE EXAMPLE OF BALLROOM DANCING

    Directory of Open Access Journals (Sweden)

    L. V. Kapilevich

    2013-01-01

    Full Text Available Learn a special coordinating pair of motor actions in athletes engaged sport ballroom dancing, depending on gender and sportsmanship. The results suggest that beginners dominated coordination, performed individually, while the highly skilled dancers better developed coordination, carried out in pairs. Athletes average individual coordination disturbed by the emergence of sex differences build movements and coordination pair is not formed. The asymmetry of the coordination abilities manifested in the predominance of the deviation from equilibrium (to the right of men and to the left – in women. In this case, the athletes of low and medium level of skill to maintain the leading element of balance and coordination is the visual analyzer, while the skilled dancers defining role goes to the vestibular apparatus.

  17. Myosin Vc Is Specialized for Transport on a Secretory Superhighway.

    Science.gov (United States)

    Sladewski, Thomas E; Krementsova, Elena B; Trybus, Kathleen M

    2016-08-22

    A hallmark of the well-studied vertebrate class Va myosin is its ability to take multiple steps on actin as a single molecule without dissociating, a feature called "processivity." Therefore, it was surprising when kinetic and single-molecule assays showed that human myosin Vc (MyoVc) was not processive on single-actin filaments [1-3]. We explored the possibility that MyoVc is processive only under conditions that resemble its biological context. Recently, it was shown that zymogen vesicles are transported on actin "superhighways" composed of parallel actin cables nucleated by formins from the plasma membrane [4]. Loss of these cables compromises orderly apical targeting of vesicles. MyoVc has been implicated in transporting secretory vesicles to the apical membrane [5]. We hypothesized that actin cables regulate the processive properties of MyoVc. We show that MyoVc is unique in taking variable size steps, which are frequently in the backward direction. Results obtained with chimeric constructs implicate the lever arm/rod of MyoVc as being responsible for these properties. Actin bundles allow single MyoVc motors to move processively. Remarkably, even teams of MyoVc motors require actin bundles to move continuously at physiological ionic strength. The irregular stepping pattern of MyoVc, which may result from flexibility in the lever arm/rod of MyoVc, appears to be a unique structural adaptation that allows the actin track to spatially restrict the activity of MyoVc to specialized actin cables in order to co-ordinate and target the final stages of vesicle secretion.

  18. Coordination Control Of Complex Machines

    NARCIS (Netherlands)

    J.C.M. Baeten; B. van Beek; J. Markovski; L.J.A.M. Somers

    2015-01-01

    Control and coordination are important aspects of the development of complex machines due to an ever-increasing demand for better functionality, quality, and performance. In WP6 of the C4C project, we developed a synthesis-centric systems engineering framework suitable for supervisory coordination o

  19. Coordinate-Free Rotation Operator.

    Science.gov (United States)

    Leubner, C.

    1979-01-01

    Suggests the use of a coordinate-free rotation operator for the teaching of rotations in Euclidean three space because of its twofold didactic advantage. Illustrates the potentialities of the coordinate-free rotation operator approach by a number of examples. (Author/GA)

  20. Coordination of Conditional Poisson Samples

    Directory of Open Access Journals (Sweden)

    Grafström Anton

    2015-12-01

    Full Text Available Sample coordination seeks to maximize or to minimize the overlap of two or more samples. The former is known as positive coordination, and the latter as negative coordination. Positive coordination is mainly used for estimation purposes and to reduce data collection costs. Negative coordination is mainly performed to diminish the response burden of the sampled units. Poisson sampling design with permanent random numbers provides an optimum coordination degree of two or more samples. The size of a Poisson sample is, however, random. Conditional Poisson (CP sampling is a modification of the classical Poisson sampling that produces a fixed-size πps sample. We introduce two methods to coordinate Conditional Poisson samples over time or simultaneously. The first one uses permanent random numbers and the list-sequential implementation of CP sampling. The second method uses a CP sample in the first selection and provides an approximate one in the second selection because the prescribed inclusion probabilities are not respected exactly. The methods are evaluated using the size of the expected sample overlap, and are compared with their competitors using Monte Carlo simulation. The new methods provide a good coordination degree of two samples, close to the performance of Poisson sampling with permanent random numbers.

  1. ORTHODONTIC MANAGEMENT IN CHILDREN WITH SPECIAL NEEDS

    OpenAIRE

    Adit ARORA; Prakash, Amit

    2013-01-01

    Special needs individuals are children or adults pre‐ vented by a physical or mental condition permitting their full participation to the normal range of activities of their age groups. They usually exhibit high orthodontic treat‐ ment needs because of an increased prevalence and seve‐ rity of malocclusions. These conditions often require a coordinated craniofacial orthodontic and surgical treat‐ ment in a team setting, to achieve optimal outcome. Ort‐ hodontic treatments for patients born wi...

  2. Fabrication of bioinspired composite nanofiber membranes with robust superhydrophobicity for direct contact membrane distillation.

    Science.gov (United States)

    Liao, Yuan; Wang, Rong; Fane, Anthony G

    2014-06-03

    The practical application of membrane distillation (MD) for water purification is hindered by the absence of desirable membranes that can fulfill the special requirements of the MD process. Compared to the membranes fabricated by other methods, nanofiber membranes produced by electrospinning are of great interest due to their high porosity, low tortuosity, large surface pore size, and high surface hydrophobicity. However, the stable performance of the nanofiber membranes in the MD process is still unsatisfactory. Inspired by the unique structure of the lotus leaf, this study aimed to develop a strategy to construct superhydrophobic composite nanofiber membranes with robust superhydrophobicity and high porosity suitable for use in MD. The newly developed membrane consists of a superhydrophobic silica-PVDF composite selective skin formed on a polyvinylidene fluoride (PVDF) porous nanofiber scaffold via electrospinning. This fabrication method could be easily scaled up due to its simple preparation procedures. The effects of silica diameter and concentration on membrane contact angle, sliding angle, and MD performance were investigated thoroughly. For the first time, the direct contact membrane distillation (DCMD) tests demonstrate that the newly developed membranes are able to present stable high performance over 50 h of testing time, and the superhydrophobic selective layer exhibits excellent durability in ultrasonic treatment and a continuous DCMD test. It is believed that this novel design strategy has great potential for MD membrane fabrication.

  3. Major Intrinsic Proteins in Biomimetic Membranes

    DEFF Research Database (Denmark)

    Helix Nielsen, Claus

    2010-01-01

    Biological membranes define the structural and functional boundaries in living cells and their organelles. The integrity of the cell depends on its ability to separate inside from outside and yet at the same time allow massive transport of matter in and out the cell. Nature has elegantly met...... this challenge by developing membranes in the form of lipid bilayers in which specialized transport proteins are incorporated. This raises the question: is it possible to mimic biological membranes and create a membrane based sensor and/or separation device? In the development of a biomimetic sensor....../separation technology, a unique class of membrane transport proteins is especially interesting the major intrinsic proteins (MIPs). Generally, MIPs conduct water molecules and selected solutes in and out of the cell while preventing the passage of other solutes, a property critical for the conservation of the cells...

  4. Flagellar membrane proteins in kinetoplastid parasites.

    Science.gov (United States)

    Landfear, Scott M; Tran, Khoa D; Sanchez, Marco A

    2015-09-01

    All kinetoplastid parasites, including protozoa such as Leishmania species, Trypanosoma brucei, and Trypanosoma cruzi that cause devastating diseases in humans and animals, are flagellated throughout their life cycles. Although flagella were originally thought of primarily as motility organelles, flagellar functions in other critical processes, especially in sensing and signal transduction, have become more fully appreciated in the recent past. The flagellar membrane is a highly specialized subdomain of the surface membrane, and flagellar membrane proteins are likely to be critical components for all the biologically important roles of flagella. In this review, we summarize recent discoveries relevant to flagellar membrane proteins in these parasites, including the identification of such proteins, investigation of their biological functions, and mechanisms of selective trafficking to the flagellar membrane. Prospects for future investigations and current unsolved problems are highlighted.

  5. Standard practice: Estimating the cost-effectiveness of coordinated DSM programs

    Energy Technology Data Exchange (ETDEWEB)

    Hill, L.J.; Brown, M.A.

    1994-12-01

    The purpose of this document is to describe and illustrate a methodology for estimating the cost-effectiveness of coordinated demand-side management (DSM) programs, extending California {open_quotes}standard practice{close_quotes} to address the special evaluation challenges arising from these programs. A coordinated DSM program is one that is co-administered by a state or local government agency and a gas or electric utility. Although the primary subject of this document is coordinated low-income programs, the principles are easily extended to estimating the cost-effectiveness of all coordinated programs.

  6. The plasma membrane proteome of germinating barley embryos

    DEFF Research Database (Denmark)

    Hynek, Radovan; Svensson, Birte; Jensen, O.N.

    2009-01-01

    was used to reduce soluble protein contamination and enrich for hydrophobic proteins. Sixty-one proteins in 14 SDS-PAGE bands were identified by LC-MS/MS and database searches. The identifications provide new insight into the plasma membrane functions in seed germination.......Cereal seed germination involves a complex coordination between different seed tissues. Plasma membranes must play crucial roles in coordination and execution of germination; however, very little is known about seed plasma membrane proteomes due to limited tissue amounts combined...... with amphiphilicity and low abundance of membrane proteins. A fraction enriched in plasma membranes was prepared from embryos dissected from 18 h germinated barley seeds using aqueous two-phase partitioning. Reversed-phase chromatography on C-4 resin performed in micro-spin columns with stepwise elution by 2-propanol...

  7. Do Environmental Education School Coordinators Have a Mission?

    Directory of Open Access Journals (Sweden)

    Šimonová Petra

    2016-12-01

    Full Text Available Teachers who are specialized in environmental education (environmental education school coordinators1 can play an important role in empowering students to shape a sustainable future. In this study, the authors examined a group of Czech environmental education school coordinators. The authors aimed to clarify how they interpret their role at their respective schools, how they perceive their self-efficacy, and what they observe as benefits and barriers to their work as a coordinator. They conducted a qualitative study with focus groups and completed individual in-depth interviews with the coordinators. The results suggest that the coordinators view their work as a mission. The ultimate goal of this mission is to change the children’s behavior to make it more pro-environmental, and, at the same time, to establish this effort as a commitment of the whole school. The authors identified different forms of mission, described development in time and connected them with the perceived self-efficacy of the coordinators.

  8. Lipids, membrane proteins and natural membranes studied by neutron scattering and diffraction: A review

    Science.gov (United States)

    Zaccai, Giuseppe

    1986-02-01

    Diffraction first observed from myelin 50 years ago was correctly attributed to a fluid crystal of lipids, because similar patterns were observed from extracted lipid preparations. Following on more recent X-ray work which characterized a variety of lipid-water structures, neutron diffraction experiments have provided detailed descriptions of the molecular conformations in lipid bilayers. For a long time, however, the molecular structure of membrane proteins remained elusive and the development of detergents for the extraction of active membrane proteins, and the discovery of naturally crystalline purple membrane were important breakthroughs in this field. Structural parameters of membrane proteins solubilised in detergent have been measured by neutron scattering with contrast variation techniques. Purple membrane has been studied extensively by neutron diffraction. It is an excellent illustration of the use of deuterium labeling by different approaches to address specific questions of molecular structure. These studies are reviewed with a special emphasis on aspects which are applicable to membranes in general.

  9. Keep Meaning in Conversational Coordination

    Directory of Open Access Journals (Sweden)

    Elena Clare Cuffari

    2014-12-01

    Full Text Available Coordination is a widely employed term across recent quantitative and qualitative approaches to intersubjectivity, particularly approaches that give embodiment and enaction central explanatory roles. With a focus on linguistic and bodily coordination in conversational contexts, I review the operational meaning of coordination in recent empirical research and related theorizing of embodied intersubjectivity. This discussion articulates what must be involved in treating linguistic meaning as dynamic processes of coordination. The coordination approach presents languaging as a set of dynamic self-organizing processes and actions on multiple timescales and across multiple modalities that come about and work in certain domains (those jointly constructed in social, interactive, high-order sense-making. These processes go beyond meaning at the level that is available to first-person experience. I take one crucial consequence of this to be the ubiquitously moral nature of languaging with others. Languaging coordinates experience, among other levels of behavior and event. Ethical effort is called for by the automatic autonomy-influencing forces of languaging as coordination.

  10. Chinese geodetic coordinate system 2000

    Institute of Scientific and Technical Information of China (English)

    YANG YuanXi

    2009-01-01

    The basic strategies In establishing the Chinese geodetic coordinate system 2000 have been summarized,including the definition of the coordinate system,the structure of the terrestrial reference frame,the functional and stochastic models involved in the realization of the reference frame as well as the Improvements of the adjustment procedures.First,the fundamental frame of the coordinate system is composed of the permanent GPS tracking network in China which is integrated into the international GPS service stations by combined adjustment,in order to guarantee the consistence between the international terrestrial reference system and the Chinese geodetic coordinate system.Second,the extended frame of the coordinate system is composed of the unified 2000' national GPS network which is Integrated by 6 nationwide GPS networks with more than 2500 stations under the controlling of the fundamental frame.Third,the densified frame is composed of national astronomical geodetic network with nearly 50 thousand stations which was updated by the combined adjustment with the 2000' national GPS network,thus the datum of the national astronomical geodetic network has been unified and the precision greatly improved.By the optimal data fusion method the influences of the datum errors,systematic errors and the outliers in the separated geodetic networks are weakened in the unified Chinese geodetic coordinate frame.The significance in application of the new geodetic coordinate system and the existing problems In the reference frame are described and analyzed.

  11. Toward a theory of coordinating: Creating coordinating mechanisms in practice

    OpenAIRE

    Jarzabkowski, P; Le, J. K.; Feldman, M. S.

    2012-01-01

    This paper uses a practice perspective to study coordinating as dynamic activities that are continuously created and modified in order to enact organizational relationships and activities. It is based on the case of Servico, an organization undergoing a major restructuring of its value chain in response to a change in government regulation. In our case, the actors iterate between the abstract concept of a coordinating mechanism referred to as end-to-end management and its performance in pract...

  12. Evaluating the Relational Coordination instrument

    DEFF Research Database (Denmark)

    Edwards, Kasper; Lundstrøm, Sanne Lykke

    2014-01-01

    and surgical performance. This has prompted the attention of both practitioners and politicians some of who perceive relational coordination as a means to attain better performance. The relational coordination instrument has been validated as a measure of teamwork from the following perspectives: internal...... consistency, interrater agreement and reliability, structural validity, content validity. However as relational coordination is being used as a diagnostics tool it is important to examine further if the instrument can measure changes. Indeed we need to know how precise and sensitive the instrument is when...

  13. From biological membranes to biomimetic model membranes

    Directory of Open Access Journals (Sweden)

    Eeman, M.

    2010-01-01

    Full Text Available Biological membranes play an essential role in the cellular protection as well as in the control and the transport of nutrients. Many mechanisms such as molecular recognition, enzymatic catalysis, cellular adhesion and membrane fusion take place into the biological membranes. In 1972, Singer et al. provided a membrane model, called fluid mosaic model, in which each leaflet of the bilayer is formed by a homogeneous environment of lipids in a fluid state including globular assembling of proteins and glycoproteins. Since its conception in 1972, many developments were brought to this model in terms of composition and molecular organization. The main development of the fluid mosaic model was made by Simons et al. (1997 and Brown et al. (1997 who suggested that membrane lipids are organized into lateral microdomains (or lipid rafts with a specific composition and a molecular dynamic that are different to the composition and the dynamic of the surrounding liquid crystalline phase. The discovery of a phase separation in the plane of the membrane has induced an explosion in the research efforts related to the biology of cell membranes but also in the development of new technologies for the study of these biological systems. Due to the high complexity of biological membranes and in order to investigate the biological processes that occur on the membrane surface or within the membrane lipid bilayer, a large number of studies are performed using biomimicking model membranes. This paper aims at revisiting the fundamental properties of biological membranes in terms of membrane composition, membrane dynamic and molecular organization, as well as at describing the most common biomimicking models that are frequently used for investigating biological processes such as membrane fusion, membrane trafficking, pore formation as well as membrane interactions at a molecular level.

  14. Numerical Hydrodynamics in Special Relativity

    Directory of Open Access Journals (Sweden)

    Martí José Maria

    2003-01-01

    Full Text Available This review is concerned with a discussion of numerical methods for the solution of the equations of special relativistic hydrodynamics (SRHD. Particular emphasis is put on a comprehensive review of the application of high-resolution shock-capturing methods in SRHD. Results of a set of demanding test bench simulations obtained with different numerical SRHD methods are compared. Three applications (astrophysical jets, gamma-ray bursts and heavy ion collisions of relativistic flows are discussed. An evaluation of various SRHD methods is presented, and future developments in SRHD are analyzed involving extension to general relativistic hydrodynamics and relativistic magneto-hydrodynamics. The review further provides FORTRAN programs to compute the exact solution of a 1D relativistic Riemann problem with zero and nonzero tangential velocities, and to simulate 1D relativistic flows in Cartesian Eulerian coordinates using the exact SRHD Riemann solver and PPM reconstruction.

  15. Numerical Hydrodynamics in Special Relativity.

    Science.gov (United States)

    Martí, José Maria; Müller, Ewald

    2003-01-01

    This review is concerned with a discussion of numerical methods for the solution of the equations of special relativistic hydrodynamics (SRHD). Particular emphasis is put on a comprehensive review of the application of high-resolution shock-capturing methods in SRHD. Results of a set of demanding test bench simulations obtained with different numerical SRHD methods are compared. Three applications (astrophysical jets, gamma-ray bursts and heavy ion collisions) of relativistic flows are discussed. An evaluation of various SRHD methods is presented, and future developments in SRHD are analyzed involving extension to general relativistic hydrodynamics and relativistic magneto-hydrodynamics. The review further provides FORTRAN programs to compute the exact solution of a 1D relativistic Riemann problem with zero and nonzero tangential velocities, and to simulate 1D relativistic flows in Cartesian Eulerian coordinates using the exact SRHD Riemann solver and PPM reconstruction.

  16. Coordination in networks for improved mental health service

    Directory of Open Access Journals (Sweden)

    Johan Hansson

    2010-08-01

    Full Text Available Background: Well-organised clinical cooperation between health and social services has been difficult to achieve in Sweden as in other countries.Purpose: This paper presents an empirical study of a mental health coordination network in one area in Stockholm. The aim was to describe the development and nature of coordination within a mental health and social care consortium and to assess the impact on care processes and client outcomes.Method: Data was gathered through interviews with coordina­tors from three rehabilitation units. The interviews focused on coordination activities aimed at supporting the clients’ needs and investigated how the coordinators acted according to the consortium's holistic approach. Data on The Camberwell Assess­ment of Need (CAN-S showing clients’ satisfaction was used to assess on set of outcomes. Findings: The findings revealed different coordination activities and factors both helping and hindering the network coordination activities. One factor helping was the history of local and personal informal cooperation and shared responsibilities evident. Unclear roles and routines hindered cooperationPractical value: The contribution is an empirical example and a model for organisations establishing structures for network coordination. One lesson for current policy about integrated health care is to adapt and implement ”pair coordinators” where full structural integration is not possible. Another lesson, based on the idea of patient quality by coordinated care, is specific to adapt the work of the local psychiatric addictive team – an independent special team in the psychiatric outpatient care serving psychotic clients with complex addictive problems.

  17. Coordination in networks for improved mental health service

    Directory of Open Access Journals (Sweden)

    Johan Hansson

    2010-08-01

    Full Text Available Background: Well-organised clinical cooperation between health and social services has been difficult to achieve in Sweden as in other countries. Purpose: This paper presents an empirical study of a mental health coordination network in one area in Stockholm. The aim was to describe the development and nature of coordination within a mental health and social care consortium and to assess the impact on care processes and client outcomes. Method: Data was gathered through interviews with coordina­tors from three rehabilitation units. The interviews focused on coordination activities aimed at supporting the clients’ needs and investigated how the coordinators acted according to the consortium's holistic approach. Data on The Camberwell Assess­ment of Need (CAN-S showing clients’ satisfaction was used to assess on set of outcomes. Findings: The findings revealed different coordination activities and factors both helping and hindering the network coordination activities. One factor helping was the history of local and personal informal cooperation and shared responsibilities evident. Unclear roles and routines hindered cooperation Practical value: The contribution is an empirical example and a model for organisations establishing structures for network coordination. One lesson for current policy about integrated health care is to adapt and implement ”pair coordinators” where full structural integration is not possible. Another lesson, based on the idea of patient quality by coordinated care, is specific to adapt the work of the local psychiatric addictive team – an independent special team in the psychiatric outpatient care serving psychotic clients with complex addictive problems.

  18. Vertical Coordination Development Mode and Influential Factors of Agricultural Products

    Institute of Scientific and Technical Information of China (English)

    Tuzhan WANG

    2016-01-01

    In China,the vertical coordination development mode of agricultural products can be divided into traditional market-oriented transaction mode with fluctuation according to market conditions,made-to-order on the basis of farmer organization,company leading cooperative mode,share or shareholding cooperative mode,and vertical integration mode. There are differences in coordination characteristics,advantages and disadvantages,and adaptability between different modes. Traditional vertical coordination mode is transforming and upgrading to close and high-efficient mode. In this process,it is influenced by factors such as cost-benefit balance between farmers and agricultural product processing enterprises,special use of agricultural product processing,structure of agricultural product industry chain,and action of local government.

  19. Special Education in Yugoslavia.

    Science.gov (United States)

    Hrnjica, Sulejman

    1990-01-01

    This article describes Yugoslavia's education system, health and welfare services for children with disabilities, the nature and organization of special education services, the integration of disabled children in ordinary schools, models for training special educators, and problems. (DB)

  20. Schwarzschild-de Sitter Metric and Inertial Beltrami Coordinates

    CERN Document Server

    Sun, Li-Feng; Deng, Ya; Huang, Wei; Hu, Sen

    2013-01-01

    Under consideration of coordinate conditions, we get the Schwarzschild-Beltrami-de Sitter (S-BdS) metric solution of the Einstein field equations with a cosmological constant $\\Lambda$. A brief review to the de Sitter invariant special relativity (dS-SR), and de Sitter general relativity (dS-GR, or GR with a $\\Lambda$) is presented. The Beltrami metric $B_{\\mu\

  1. Transparency and Coordinated Effects in European Merger Control

    DEFF Research Database (Denmark)

    Albæk, Svend; Møllgaard, H. Peter; Overgaard, Per Baltzer

    2010-01-01

    In this paper, we first outline the foundations in economic theory of so-called coordinated effects with a particular view to mergers and with a special focus on transparency. Then, we review a number of seminal merger cases in EU competition policy (Airtours, Sony/BMG, ABF/GBI Business) in light...... widespread in the market in question. Finally, we briefly present a few other cases in which transparency has been an issue....

  2. Supramolecular Organization of Porphyrin and Phthalocyanine by Complementary Coordination

    Institute of Scientific and Technical Information of China (English)

    Yoshiaki; Kobuke; Masakuni; Fujita; Toshimasa; Sugimura; Akiharu; Satake

    2007-01-01

    1 Results We have already established a methodology of supramolecular organization of porphyrin and phthalocyanine by complementary coordination of the imidazolyl substituent to their metal centers.Since the stability constants reached a range of 1011 to 1012 M-1 in nonpolar solvents,it allowed construction of stable structures such as special pair of photosynthetic reaction center and light-harvesting antenna complex of photosynthetic bacteria.Here,we report one-dimensional array of porphyrin for the d...

  3. Calcium binding to the purple membrane : A molecular dynamics study

    NARCIS (Netherlands)

    Wassenaar, Tsjerk A.; Daura, Xavier; Padros, Esteve; Mark, Alan E.

    2009-01-01

    The purple membrane (PM) is a specialized membrane patch found in halophilic archaea, containing the photoreceptor bacteriorhodopsin (bR). It is long known that calcium ions bind to the PM, but their position and role remain elusive to date. Molecular dynamics simulations in conjunction with a highl

  4. Facilitated oxygen transport in liquid membranes: review and new concepts

    NARCIS (Netherlands)

    Figoli, A.; Sager, W.F.C.; Mulder, M.H.V.

    2001-01-01

    In this paper, an overview is given on membranes with oxygen facilitated transport properties to enrich the oxygen content in air. Special emphasis is paid to recent developments of oxygen carrier systems and carrier containing membranes. Concepts leading to a structural evolution of supported liqui

  5. Thin film composite nanofiltration membranes for extreme conditions

    NARCIS (Netherlands)

    Dalwani, Mayur Ramesh

    2011-01-01

    The research presented in this thesis focuses on development and performance evaluation of thin film composite (TFC) nanofiltration (NF) membranes, with special attention to extreme pH applications. In Chapter 2 a new method that allows molecular weight cut off (MWCO) characterization of NF membran

  6. Microporous Inorganic Membranes as Proton Exchange Membranes

    Energy Technology Data Exchange (ETDEWEB)

    Vichi, F.M. Tejedor-Tejedor, M.I. Anderson, Marc A

    2002-08-28

    Porous oxide electrolyte membranes provide an alternative approach to fabricating proton exchange membrane fuel cells based on inorganic materials. This study focused on elucidating the properties of these inorganic membranes that make them good electrolyte materials in membrane electrode assemblies; in particular, we investigated several properties that affect the nature of proton conductivity in these membranes. This report discusses our findings on the effect of variables such as site density, amount of surface protonation and surface modification on the proton conductivity of membranes with a fixed pore structure under selected conditions. Proton conductivities of these inorganic membranes are similar to conductivities of nafion, the polymeric membrane most commonly used in low temperature fuel cells.

  7. Still more complexity in mammalian basement membranes

    DEFF Research Database (Denmark)

    Erickson, A C; Couchman, J R

    2000-01-01

    At the epithelial/mesenchymal interface of most tissues lies the basement membrane (BM). These thin sheets of highly specialized extracellular matrix vary in composition in a tissue-specific manner, and during development and repair. For about two decades it has been apparent that all BMs contain...

  8. A computational formulation for constrained solid and liquid membranes considering isogeometric finite elements

    CERN Document Server

    Sauer, Roger A; Corbett, Callum J

    2012-01-01

    A geometrically exact membrane formulation is presented that is based on curvilinear coordinates and isogeometric finite elements, and is suitable for both solid and liquid membranes. The curvilinear coordinate system is used to describe both the theory and the finite element equations of the membrane. In the latter case this avoids the use of local cartesian coordinates at the element level. Consequently, no transformation of derivatives is required. The formulation considers a split of the in-plane and out-of-plane membrane contributions, which allows the construction of a stable formulation for liquid membranes with constant surface tension. The proposed membrane formulation is general, and accounts for dead and live loading, as well as enclosed volume, area, and contact constraints. The new formulation is illustrated by several challenging examples, considering linear and quadratic Lagrange elements, as well as isogeometric elements based on quadratic NURBS and cubic T-splines. It is seen that the isogeom...

  9. Some properties of emission coordinates

    CERN Document Server

    Pozo, J M

    2006-01-01

    4 emitters broadcasting an increasing electromagnetic signal generate a system of relativistic coordinates for the space-time, called emission coordinates. Their physical realization requires an apparatus similar to the one of the Global Navigation Satellite Systems (GNSS). Several relativistic corrections are utilized for the current precisions, but the GNSS are conceived as classical (Newtonian) systems, which has deep implications in the way of operating them. The study of emission coordinates is an essential step in order to develop a fully relativistic theory of positioning systems. This talk presents some properties of emission coordinates. In particular, we characterize how any observer sees a configuration of satellites giving a degenerated system and show that the trajectories of the satellites select a unique privileged observer at each point and, for any observer, a set of 3 orthogonal spatial axes.

  10. Coordination Games on Dynamical Networks

    Directory of Open Access Journals (Sweden)

    Enea Pestelacci

    2010-07-01

    Full Text Available We propose a model in which agents of a population interacting according to a network of contacts play games of coordination with each other and can also dynamically break and redirect links to neighbors if they are unsatisfied. As a result, there is co-evolution of strategies in the population and of the graph that represents the network of contacts. We apply the model to the class of pure and general coordination games. For pure coordination games, the networks co-evolve towards the polarization of different strategies. In the case of general coordination games our results show that the possibility of refusing neighbors and choosing different partners increases the success rate of the Pareto-dominant equilibrium.

  11. Fedosov supermanifolds: II. Normal coordinates

    CERN Document Server

    Geyer, B; Geyer, Bodo; Lavrov, Peter

    2004-01-01

    The study of recently introduced Fedosov supermanifolds is continued. Using normal coordinates, properties of even and odd symplectic supermanifolds endowed with a symmetric connection respecting given sympletic structure are studied.

  12. Surface normals and barycentric coordinates

    Directory of Open Access Journals (Sweden)

    Mullineux Glen

    1996-01-01

    Full Text Available The normal to a triangular parametric surface is investigated where the parameters used are barycentric coordinates. Formulae for the normal are obtained for non-rational and rational surfaces.

  13. Ellipsoidal analysis of coordination polyhedra

    Science.gov (United States)

    Cumby, James; Attfield, J. Paul

    2017-02-01

    The idea of the coordination polyhedron is essential to understanding chemical structure. Simple polyhedra in crystalline compounds are often deformed due to structural complexity or electronic instabilities so distortion analysis methods are useful. Here we demonstrate that analysis of the minimum bounding ellipsoid of a coordination polyhedron provides a general method for studying distortion, yielding parameters that are sensitive to various orders in metal oxide examples. Ellipsoidal analysis leads to discovery of a general switching of polyhedral distortions at symmetry-disallowed transitions in perovskites that may evidence underlying coordination bistability, and reveals a weak off-centre `d5 effect' for Fe3+ ions that could be exploited in multiferroics. Separating electronic distortions from intrinsic deformations within the low temperature superstructure of magnetite provides new insights into the charge and trimeron orders. Ellipsoidal analysis can be useful for exploring local structure in many materials such as coordination complexes and frameworks, organometallics and organic molecules.

  14. On Sector Magnets or Transverse Electromagnetic Fields in Cylindrical Coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Zolkin, Timofey [Fermilab

    2016-03-10

    The Laplace's equations for the scalar and vector potentials describing electric or magnetic fields in cylindrical coordinates with translational invariance along azimuthal coordinate are considered. The series of special functions which, when expanded in power series in radial and vertical coordinates, in lowest order replicate the harmonic homogeneous polynomials of two variables are found. These functions are based on radial harmonics found by Edwin~M.~McMillan in his more-than-40-years "forgotten" article, which will be discussed. In addition to McMillan's harmonics, second family of adjoint radial harmonics is introduced, in order to provide symmetric description between electric and magnetic fields and to describe fields and potentials in terms of same special functions. Formulas to relate any transverse fields specified by the coefficients in the power series expansion in radial or vertical planes in cylindrical coordinates with the set of new functions are provided. This result is no doubt important for potential theory while also critical for theoretical studies, design and proper modeling of sector dipoles, combined function dipoles and any general sector element for accelerator physics. All results are presented in connection with these problems.

  15. Kaluza's theory in generalized coordinates

    CERN Document Server

    García-Perciante, A L; García-Colin, L S; Garcia-Perciante, Ana Laura; Sandoval-Villalbazo, Alfredo

    2001-01-01

    Maxwell's equations can be obtained in generalized coordinates by considering the electromagnetic field as an external agent. The work here presented shows how to obtain the electrodynamics for a charged particle in generalized coordinates eliminating the concept of external force. Based on Kaluza's formalism, the one here presented extends the 5x5 metric into a 6x6 space-time giving enough room to include magnetic monopoles in a very natural way.

  16. Coordination theory and collaboration technology

    CERN Document Server

    Olson, Gary M; Smith, John B

    2001-01-01

    The National Science Foundation funded the first Coordination Theory and Collaboration Technology initiative to look at systems that support collaborations in business and elsewhere. This book explores the global revolution in human interconnectedness. It will discuss the various collaborative workgroups and their use in technology. The initiative focuses on processes of coordination and cooperation among autonomous units in human systems, in computer and communication systems, and in hybrid organizations of both systems. This initiative is motivated by three scientific issues which have been

  17. Inflation, Growth and Policy Coordination

    OpenAIRE

    Renato E. Reside Jr.; Parantap Basu

    1996-01-01

    The effect of monetary policy on output growth and inflation is examined in a monetary endogenous growth model with an explicit banking sector that intermediates capital. Monetary policy is coordinated with fiscal policy in the sense that all the seigniorage revenue gleaned through the inflation tax is spent to make efficient provision of public services. With the reserve requirement and money growth as instruments, policy coordination implies that one instrument may be solved endogenously wh...

  18. Anaerobic membrane bioreactors: Are membranes really necessary?

    NARCIS (Netherlands)

    Davila, M.; Kassab, G.; Klapwijk, A.; Lier, van J.B.

    2008-01-01

    Membranes themselves represent a significant cost for the full scale application of anaerobic membrane bioreactors (AnMBR). The possibility of operating an AnMBR with a self-forming dynamic membrane generated by the substances present in the reactor liquor would translate into an important saving. A

  19. Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.

    Science.gov (United States)

    Pelkey, Kenneth A; Barksdale, Elizabeth; Craig, Michael T; Yuan, Xiaoqing; Sukumaran, Madhav; Vargish, Geoffrey A; Mitchell, Robert M; Wyeth, Megan S; Petralia, Ronald S; Chittajallu, Ramesh; Karlsson, Rose-Marie; Cameron, Heather A; Murata, Yasunobu; Colonnese, Matthew T; Worley, Paul F; McBain, Chris J

    2015-03-18

    Circuit computation requires precision in the timing, extent, and synchrony of principal cell (PC) firing that is largely enforced by parvalbumin-expressing, fast-spiking interneurons (PVFSIs). To reliably coordinate network activity, PVFSIs exhibit specialized synaptic and membrane properties that promote efficient afferent recruitment such as expression of high-conductance, rapidly gating, GluA4-containing AMPA receptors (AMPARs). We found that PVFSIs upregulate GluA4 during the second postnatal week coincident with increases in the AMPAR clustering proteins NPTX2 and NPTXR. Moreover, GluA4 is dramatically reduced in NPTX2(-/-)/NPTXR(-/-) mice with consequent reductions in PVFSI AMPAR function. Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials. Juvenile NPTX2(-/-)/NPTXR(-/-) mice display reduced feedforward inhibition yielding a circuit deficient in rhythmogenesis and prone to epileptiform discharges. Our findings demonstrate an essential role for NPTXs in controlling network dynamics highlighting potential therapeutic targets for disorders with inhibition/excitation imbalances such as schizophrenia.

  20. Model cell membranes

    DEFF Research Database (Denmark)

    Günther-Pomorski, Thomas; Nylander, Tommy; Cardenas Gomez, Marite

    2014-01-01

    The high complexity of biological membranes has motivated the development and application of a wide range of model membrane systems to study biochemical and biophysical aspects of membranes in situ under well defined conditions. The aim is to provide fundamental understanding of processes...... controlled by membrane structure, permeability and curvature as well as membrane proteins by using a wide range of biochemical, biophysical and microscopic techniques. This review gives an overview of some currently used model biomembrane systems. We will also discuss some key membrane protein properties...... that are relevant for protein-membrane interactions in terms of protein structure and how it is affected by membrane composition, phase behavior and curvature....

  1. Managing interteam coordination within and between organizations

    NARCIS (Netherlands)

    de Vries, Thomas Arend

    2015-01-01

    To accomplish complex tasks and effectively respond to environmental contingencies, teams must coordinate task-related issues with other teams (i.e., interteam coordination). Regrettably, interteam coordination is often complicated by misunderstandings that can arise from differences in teams’

  2. Conforming to coordinate: children use majority information for peer coordination.

    Science.gov (United States)

    Grueneisen, Sebastian; Wyman, Emily; Tomasello, Michael

    2015-03-01

    Humans are constantly required to coordinate their behaviour with others. As this often relies on everyone's convergence on the same strategy (e.g., driving on the left side of the road), a common solution is to conform to majority behaviour. In this study, we presented 5-year-old children with a coordination problem: To retrieve some rewards, they had to choose the same of four options as a peer partner--in reality a stooge--whose decision they were unable to see. Before making a choice, they watched a video showing how other children from their partner's peer group had behaved; a majority chose the same option and a minority chose a different one. In a control condition, children watched the same video but could then retrieve the reward irrespective of their partner's choice (i.e., no coordination was necessary). Children followed the majority more often when coordination was required. Moreover, conformers mostly justified their choices by referring to the majority from the video demonstration. This study is the first to show that young children are able to strategically coordinate decisions with peers by conforming to the majority.

  3. Metallogels from Coordination Complexes, Organometallic, and Coordination Polymers.

    Science.gov (United States)

    Dastidar, Parthasarathi; Ganguly, Sumi; Sarkar, Koushik

    2016-09-20

    A supramolecular gel results from the immobilization of solvent molecules on a 3D network of gelator molecules stabilized by various supramolecular interactions that include hydrogen bonding, π-π stacking, van der Waals interactions, and halogen bonding. In a metallogel, a metal is a part of the gel network as a coordinated metal ion (in a discrete coordination complex), as a cross-linking metal node with a multitopic ligand (in coordination polymer), and as metal nanoparticles adhered to the gel network. Although the field is relatively new, research into metallogels has experienced a considerable upsurge owing to its fundamental importance in supramolecular chemistry and various potential applications. This focus review aims to provide an insight into the development of designing metallogelators. Because of the limited scope, discussions are confined to examples pertaining to metallogelators derived from discrete coordination complexes, organometallic gelators, and coordination polymers. This review is expected to enlighten readers on the current development of designing metallogelators of the abovementioned class of molecules. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Erythrocyte membrane proteins and membrane skeleton

    Institute of Scientific and Technical Information of China (English)

    LU Yiqin; LIU Junfan

    2007-01-01

    Considerable advances in the research field of erythrocyte membrane were achieved in the recent two decades.New findings in the structure-function correlation and interactions of erythrocyte membrane proteins have attracted extensive attention.Interesting progress was also made in the molecular pathogenesis of erythrocyte membrane disorders.Advances in the composition,function and interaction of erythrocyte membrane proteins,erythrocyte membrane skeleton,and relevant diseases are briefly described and summarized here on the basis of domestic and world literatures.

  5. Specific interaction of IM30/Vipp1 with cyanobacterial and chloroplast membranes results in membrane remodeling and eventually in membrane fusion.

    Science.gov (United States)

    Heidrich, Jennifer; Thurotte, Adrien; Schneider, Dirk

    2017-04-01

    The photosynthetic light reaction takes place within the thylakoid membrane system in cyanobacteria and chloroplasts. Besides its global importance, the biogenesis, maintenance and dynamics of this membrane system are still a mystery. In the last two decades, strong evidence supported the idea that these processes involve IM30, the inner membrane-associated protein of 30kDa, a protein also known as the vesicle-inducing protein in plastids 1 (Vipp1). Even though we just only begin to understand the precise physiological function of this protein, it is clear that interaction of IM30 with membranes is crucial for biogenesis of thylakoid membranes. Here we summarize and discuss forces guiding IM30-membrane interactions, as the membrane properties as well as the oligomeric state of IM30 appear to affect proper interaction of IM30 with membrane surfaces. Interaction of IM30 with membranes results in an altered membrane structure and can finally trigger fusion of adjacent membranes, when Mg(2+) is present. Based on recent results, we finally present a model summarizing individual steps involved in IM30-mediated membrane fusion. This article is part of a Special Issue entitled: Lipid order/lipid defects and lipid-control of protein activity edited by Dirk Schneider.

  6. Special Killing forms on toric Sasaki-Einstein manifolds

    CERN Document Server

    Slesar, Vladimir; Vilcu, Gabriel Eduard

    2014-01-01

    In this paper we study the interplay between complex coordinates of the Calabi-Yau metric cone and the special Killing forms on the toric Sasaki-Einstein manifold. In the general case we give a procedure to locally construct the special Killing forms. In the final part we exemplify the general scheme in the case of the 5-dimensional $Y^{p,q}$ spaces.

  7. Perception and action influences on discrete and reciprocal bimanual coordination.

    Science.gov (United States)

    Shea, Charles H; Buchanan, John J; Kennedy, Deanna M

    2016-04-01

    For nearly four decades bimanual coordination, "a prototype of complex motor skills" and apparent "window into the design of the brain," has been intensively studied. Past research has focused on describing and modeling the constraints that allow the production of some coordination patterns while limiting effective performance of other bimanual coordination patterns. More recently researchers have identified a coalition of perception-action constraints that hinder the effective production of bimanual skills. The result has been that given specially designed contexts where one or more of these constraints are minimized, bimanual skills once thought difficult, if not impossible, to effectively produce without very extensive practice can be executed effectively with little or no practice. The challenge is to understand how these contextual constraints interact to allow or inhibit the production of complex bimanual coordination skills. In addition, the factors affecting the stability of bimanual coordination tasks needs to be re-conceptualized in terms of perception-related constraints arising from the environmental context in which performance is conducted and action constraints resident in the neuromotor system.

  8. Analysis of Geographic Coordinates of the Meteorological Post at Zrinjevac

    Directory of Open Access Journals (Sweden)

    Drago Špoljarić

    2016-06-01

    Full Text Available The Meteorological Post at Zrinjevac built in 1884 is a public meteorological station where many citizens and visitors can obtain information about temperature, humidity and air pressure in the centre of the town. Based on the available documentation, the paper presents the analysis of geographic coordinates of the post, their reliability (accuracy – referring to whether they determine the real position of the post and who and when determined them. There are also the analysed coordinates given that were established by Ivan Stožir in 1884, then the coordinates read by Guro Pila in 1890 from the new special map of Austro-Hungarian Monarchy and converted in 1941 by Nikolaj Abakumov from rectangular coordinates from the cadastral plan, and finally, the coordinates determined by means of modern GNSS measuring systems. There are also the changes of the form and the contents of the post show window described that took place on the occasion of two great restorations in 1959 and 1993 and were done in accordance with its modernisation. The clock with the 24-hour dial is also described. The times of sunrise and sunset in Zagreb have been checked and recalculated.

  9. Vesicular and Plasma Membrane Transporters for Neurotransmitters

    OpenAIRE

    2012-01-01

    The regulated exocytosis that mediates chemical signaling at synapses requires mechanisms to coordinate the immediate response to stimulation with the recycling needed to sustain release. Two general classes of transporter contribute to release, one located on synaptic vesicles that loads them with transmitter, and a second at the plasma membrane that both terminates signaling and serves to recycle transmitter for subsequent rounds of release. Originally identified as the target of psychoacti...

  10. Werner coordination chemistry and neurodegeneration.

    Science.gov (United States)

    Telpoukhovskaia, Maria A; Orvig, Chris

    2013-02-21

    Neurodegenerative diseases are capturing the world's attention as being the next set of diseases we must tackle collectively. Not only are the patients experiencing gradual cognitive and physical decline in most cases, but these diseases are fatal with no prevention currently available. As these diseases are progressive, providing care and symptom treatment for the ageing population is becoming both a medical and a financial challenge. This review discusses how Werner coordination chemistry plays a role in three diseases - those of Alzheimer's, Parkinson's, and prions. Metal ions are considered to be involved in these diseases in part via their propensity to cause toxic aggregation of proteins. First, the coordination of metal ions, with emphasis on copper(II), to metalloproteins that are hallmarks of these diseases - amyloid β, α-synuclein, and prion, respectively - will be discussed. We will present the current understanding of the metal coordination environments created by the amino acids of these proteins, as well as metal binding affinity. Second, a diverse set of examples of rationally designed metal chelators to outcompete this deleterious binding will be examined based on coordination mode and affinity toward bio-relevant metal ions. Overall, this review will give a general overview of protein and metal chelator coordination environments in neurodegenerative diseases.

  11. Magnetically controlled permeability membranes

    KAUST Repository

    Kosel, Jurgen

    2013-10-31

    A bioactive material delivery system can include a thermoresponsive polymer membrane and nanowires distributed within the thermoresponsive polymer membrane. Magnetic activation of a thermoresponsive polymer membrane can take place via altering the magnetization or dimensions of nanowires dispersed or ordered within the membrane matrix.

  12. Compositional asynchronous membrane systems

    Institute of Scientific and Technical Information of China (English)

    Cosmin Bonchis; Cornel Izbasa; Gabriel Ciobanu

    2007-01-01

    This paper presents an algorithmic way of building complex membrane systems by coupling elementary membranes. Its application seems particularly valuable in the case of asynchronous membrane systems, since the resulting membrane system remains asynchronous. The composition method is based on a handshake mechanism implemented by using antiport rules and promoters.

  13. Composite sensor membrane

    Science.gov (United States)

    Majumdar, Arun; Satyanarayana, Srinath; Yue, Min

    2008-03-18

    A sensor may include a membrane to deflect in response to a change in surface stress, where a layer on the membrane is to couple one or more probe molecules with the membrane. The membrane may deflect when a target molecule reacts with one or more probe molecules.

  14. Biomimetic membranes for sensor and separation applications

    DEFF Research Database (Denmark)

    Helix Nielsen, Claus

    2009-01-01

    massive transport of matter in and out the cell. Nature has elegantly met this challenge by developing membranes in the form of lipid bilayers in which specialized and highly efficient transport proteins are incorporated. This raises the question: is it possible to mimic biological membranes and create...... membrane-based sensor and/or separation devices? In the development of biomimetic sensor/separation technology, both channels (ion and water channels) and carriers (transporters) are important. Generally, each class of transport proteins conducts specific molecular species in and out of the cell while...... preventing the passage of others, a property critical for the overall conservation of the cells internal pH and salt concentration. Both ion and water channels are highly efficient membrane pore proteins capable of transporting solutes at very high rates, up to 109 molecules per second. Carrier proteins...

  15. Major Intrinsic Proteins in Biomimetic Membranes

    DEFF Research Database (Denmark)

    Helix Nielsen, Claus

    2010-01-01

    this challenge by developing membranes in the form of lipid bilayers in which specialized transport proteins are incorporated. This raises the question: is it possible to mimic biological membranes and create a membrane based sensor and/or separation device? In the development of a biomimetic sensor...... or as sensor devices based on e.g., the selective permeation of metalloids. In principle a MIP based membrane sensor/separation device requires the supporting biomimetic matrix to be virtually impermeable to anything but water or the solute in question. In practice, however, a biomimetic support matrix...... will generally have finite permeabilities to both electrolytes and non-electrolytes. The feasibility of a biomimetic MIP device thus depends on the relative transport contribution from both protein and biomimetic support matrix. Also the biomimetic matrix must be encapsulated in order to protect it and make...

  16. Spatio-temporal Remodeling of Functional Membrane Microdomains Organizes the Signaling Networks of a Bacterium

    NARCIS (Netherlands)

    Schneider, Johannes; Klein, Teresa; Mielich-Süss, Benjamin; Koch, Gudrun; Franke, Christian; Kuipers, Oscar P; Kovács, Ákos T; Sauer, Markus; Lopez, Daniel

    2015-01-01

    Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion. It has been proposed that this functional diversity would require a hete

  17. Simulations of outer membrane channels and their permeability.

    Science.gov (United States)

    Pothula, Karunakar R; Solano, Carlos J F; Kleinekathöfer, Ulrich

    2016-07-01

    Channels in the outer membrane of Gram-negative bacteria provide essential pathways for the controlled and unidirectional transport of ions, nutrients and metabolites into the cell. At the same time the outer membrane serves as a physical barrier for the penetration of noxious substances such as antibiotics into the bacteria. Most antibiotics have to pass through these membrane channels to either reach cytoplasmic bound targets or to further cross the hydrophobic inner membrane. Considering the pharmaceutical significance of antibiotics, understanding the functional role and mechanism of these channels is of fundamental importance in developing strategies to design new drugs with enhanced permeation abilities. Due to the biological complexity of membrane channels and experimental limitations, computer simulations have proven to be a powerful tool to investigate the structure, dynamics and interactions of membrane channels. Considerable progress has been made in computer simulations of membrane channels during the last decade. The goal of this review is to provide an overview of the computational techniques and their roles in modeling the transport across outer membrane channels. A special emphasis is put on all-atom molecular dynamics simulations employed to better understand the transport of molecules. Moreover, recent molecular simulations of ion, substrate and antibiotics translocation through membrane pores are briefly summarized. This article is part of a Special Issue entitled: Membrane Proteins edited by J.C. Gumbart and Sergei Noskov.

  18. Active membrane having uniform physico-chemically functionalized ion channels

    Science.gov (United States)

    Gerald, II, Rex E; Ruscic, Katarina J; Sears, Devin N; Smith, Luis J; Klingler, Robert J; Rathke, Jerome W

    2012-09-24

    The present invention relates to a physicochemically-active porous membrane for electrochemical cells that purports dual functions: an electronic insulator (separator) and a unidirectional ion-transporter (electrolyte). The electrochemical cell membrane is activated for the transport of ions by contiguous ion coordination sites on the interior two-dimensional surfaces of the trans-membrane unidirectional pores. One dimension of the pore surface has a macroscopic length (1 nm-1000 .mu.m) and is directed parallel to the direction of an electric field, which is produced between the cathode and the anode electrodes of an electrochemical cell. The membrane material is designed to have physicochemical interaction with ions. Control of the extent of the interactions between the ions and the interior pore walls of the membrane and other materials, chemicals, or structures contained within the pores provides adjustability of the ionic conductivity of the membrane.

  19. Biogenesis of inner membrane proteins in Escherichia coli.

    Science.gov (United States)

    Luirink, Joen; Yu, Zhong; Wagner, Samuel; de Gier, Jan-Willem

    2012-06-01

    The inner membrane proteome of the model organism Escherichia coli is composed of inner membrane proteins, lipoproteins and peripherally attached soluble proteins. Our knowledge of the biogenesis of inner membrane proteins is rapidly increasing. This is in particular true for the early steps of biogenesis - protein targeting to and insertion into the membrane. However, our knowledge of inner membrane protein folding and quality control is still fragmentary. Furthering our knowledge in these areas will bring us closer to understand the biogenesis of individual inner membrane proteins in the context of the biogenesis of the inner membrane proteome of Escherichia coli as a whole. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes.

  20. Coordination function disorders and their evaluation in patients with Chiari malformation type 1

    Directory of Open Access Journals (Sweden)

    D N Dunin

    2012-01-01

    Full Text Available To study a range of coordination disorders in Chiari malformation type 1 (CM1, a clinical examination and magnetic resonance imaging (MRI were made in 73 patients (52 women and 21 men aged 17 to 71 years with this disorder. Special tests were used to identify cerebellar and vestibular disorders. Vertigo was noted in 76.7% of the patients with CM1. The special tests revealed impaired coordination in the majority (93.1% of the patients. Babinsky’s asynergy was the most common (52% of the patients symptom of coordination disorders. The findings confirmed the high rate of coordination disorders in CM1 and the informative value of supplementary studies of cerebellar and vestibular functions along with routine evaluation of the neurological status.

  1. The status of physical training judoists of 14–16 years on indicators coordinating abilities

    Directory of Open Access Journals (Sweden)

    Chumak Yuliia

    2014-08-01

    Full Text Available Purpose: to determine the impact of the special physical training aimed at developing coordination skills. Material and Methods: in 57 explored participated judo 14-16 years old male, who trained at the stage of the specially-basic training. Methods: Analysis of scientific and technical literature, testing physical properties, methods of mathematical statistics. Results: actual problems of physical training judo. the level of physical fitness for the performance of coordination abilities. Analyzed the typical training program for judo and determined its effectiveness. Conclusions: found that physical training judo 14–16 years on indicators of quality of coordination within the average. Therefore, to achieve good results in the need to improve the modern sport judo training program. Formed guidelines for building a training process designed to develop coordination skills.

  2. Global Proteomic Analysis Reveals an Exclusive Role of Thylakoid Membranes in Bioenergetics of a Model Cyanobacterium

    Energy Technology Data Exchange (ETDEWEB)

    Liberton, Michelle; Saha, Rajib; Jacobs, Jon M.; Nguyen, Amelia Y.; Gritsenko, Marina A.; Smith, Richard D.; Koppenaal, David W.; Pakrasi, Himadri B.

    2016-04-07

    Cyanobacteria are photosynthetic microbes with highly differentiated membrane systems. These organisms contain an outer membrane, plasma membrane, and an internal system of thylakoid membranes where the photosynthetic and respiratory machinery are found. This existence of compartmentalization and differentiation of membrane systems poses a number of challenges for cyanobacterial cells in terms of organization and distribution of proteins to the correct membrane system. Proteomics studies have long sought to identify the components of the different membrane systems, and to date about 450 different proteins have been attributed to either the plasma membrane or thylakoid membrane. Given the complexity of these membranes, many more proteins remain to be identified in these membrane systems, and a comprehensive catalog of plasma membrane and thylakoid membrane proteins is needed. Here we describe the identification of 635 proteins in Synechocystis sp. PCC 6803 by quantitative iTRAQ isobaric labeling; of these, 459 proteins were localized to the plasma membrane and 176 were localized to the thylakoid membrane. Surprisingly, we found over 2.5 times the number of unique proteins identified in the plasma membrane compared to the thylakoid membrane. This suggests that the protein composition of the thylakoid membrane is more homogeneous than the plasma membrane, consistent with the role of the plasma membrane in diverse cellular processes including protein trafficking and nutrient import, compared to a more specialized role for the thylakoid membrane in cellular energetics. Overall, the protein composition of the Synechocystis 6803 plasma membrane and thylakoid membrane is quite similar to the E.coli plasma membrane and Arabidopsis thylakoid membrane, respectively. Synechocystis 6803 can therefore be described as a gram-negative bacterium that has an additional internal membrane system that fulfils the energetic requirements of the cell.

  3. Global Proteomic Analysis Reveals an Exclusive Role of Thylakoid Membranes in Bioenergetics of a Model Cyanobacterium.

    Science.gov (United States)

    Liberton, Michelle; Saha, Rajib; Jacobs, Jon M; Nguyen, Amelia Y; Gritsenko, Marina A; Smith, Richard D; Koppenaal, David W; Pakrasi, Himadri B

    2016-06-01

    Cyanobacteria are photosynthetic microbes with highly differentiated membrane systems. These organisms contain an outer membrane, plasma membrane, and an internal system of thylakoid membranes where the photosynthetic and respiratory machinery are found. This existence of compartmentalization and differentiation of membrane systems poses a number of challenges for cyanobacterial cells in terms of organization and distribution of proteins to the correct membrane system. Proteomics studies have long sought to identify the components of the different membrane systems in cyanobacteria, and to date about 450 different proteins have been attributed to either the plasma membrane or thylakoid membrane. Given the complexity of these membranes, many more proteins remain to be identified, and a comprehensive catalogue of plasma membrane and thylakoid membrane proteins is needed. Here we describe the identification of 635 differentially localized proteins in Synechocystis sp. PCC 6803 by quantitative iTRAQ isobaric labeling; of these, 459 proteins were localized to the plasma membrane and 176 were localized to the thylakoid membrane. Surprisingly, we found over 2.5 times the number of unique proteins identified in the plasma membrane compared with the thylakoid membrane. This suggests that the protein composition of the thylakoid membrane is more homogeneous than the plasma membrane, consistent with the role of the plasma membrane in diverse cellular processes including protein trafficking and nutrient import, compared with a more specialized role for the thylakoid membrane in cellular energetics. Thus, our data clearly define the two membrane systems with distinct functions. Overall, the protein compositions of the Synechocystis 6803 plasma membrane and thylakoid membrane are quite similar to that of the plasma membrane of Escherichia coli and thylakoid membrane of Arabidopsis chloroplasts, respectively. Synechocystis 6803 can therefore be described as a Gram

  4. Global Proteomic Analysis Reveals an Exclusive Role of Thylakoid Membranes in Bioenergetics of a Model Cyanobacterium

    Energy Technology Data Exchange (ETDEWEB)

    Liberton, Michelle; Saha, Rajib; Jacobs, Jon M.; Nguyen, Amelia Y.; Gritsenko, Marina A.; Smith, Richard D.; Koppenaal, David W.; Pakrasi, Himadri B.

    2016-04-07

    Cyanobacteria are photosynthetic microbes with highlydifferentiated membrane systems. These organisms contain an outer membrane, plasma membrane, and an internal system of thylakoid membranes where the photosynthetic and respiratory machinery are found. This existence of compartmentalization and differentiation of membrane systems poses a number of challenges for cyanobacterial cells in terms of organization and distribution of proteins to the correct membrane system. Proteomics studies have long sought to identify the components of the different membrane systems in cyanobacteria, and to date about 450 different proteins have been attributed to either the plasma membrane or thylakoid membrane. Given the complexity of these membranes, many more proteins remain to be identified, and a comprehensive catalogue of plasma membrane and thylakoid membrane proteins is needed. Here we describe the identification of 635 differentially localized proteins in Synechocystis sp. PCC 6803 by quantitative iTRAQ isobaric labeling; of these, 459 proteins were localized to the plasma membrane and 176 were localized to the thylakoid membrane. Surprisingly, we found over 2.5 times the number of unique proteins identified in the plasma membrane compared with the thylakoid membrane. This suggests that the protein composition of the thylakoid membrane is more homogeneous than the plasma membrane, consistent with the role of the plasma membrane in diverse cellular processes including protein trafficking and nutrient import, compared with a more specialized role for the thylakoid membrane in cellular energetics. Thus, our data clearly define the two membrane systems with distinct functions. Overall, the protein compositions of the Synechocystis 6803 plasma membrane and thylakoid membrane are quite similar to that of the plasma membrane of Escherichia coli and thylakoid membrane of Arabidopsis chloroplasts, respectively. Synechocystis 6803 can therefore be described as a Gram

  5. Overview of Specialized Courts

    OpenAIRE

    2009-01-01

    This Overview has two primary purposes. First, it provides judicial system officials with the arguments in favor of and in opposition to the creation of specialized courts. Second, it offers recommendations for consideration by judicial system officials when they are deliberating whether to establish specialized courts. This Overview also provides a review of types of specialized courts that have been established in court systems in some countries in Europe and the United States. This review ...

  6. 2007 special equipment safety

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The General Administration of Quality Supervision, Inspection and Quarantine of P.R.China (AQSIQ) issued a notice on May 28, 2007,requiring various locations to rectify their procedures for checking special equipment and hoisting machines for hidden problems. To further clarify and implement responsibility in the safety management of special equipment in enterprises, inspection responsibilities and test organizations related to technical assurance are to be established. Further, quality inspection departments will be supervised by law in order to improve special equipment safety.

  7. COCO: Conversion of Celestial Coordinates

    Science.gov (United States)

    Wallace, Patrick

    2014-06-01

    The COCO program converts star coordinates from one system to another. Both the improved IAU system, post-1976, and the old pre-1976 system are supported. COCO can perform accurate transformations between multiple coordinate systems. COCO's user-interface is spartan but efficient and the program offers control over report resolution. All input is free-format, and defaults are provided where this is meaningful. COCO uses SLALIB (ascl:1403.025) and is distributed as part of the Starlink software collection (ascl:1110.012).

  8. A coordination language for databases

    DEFF Research Database (Denmark)

    Li, Ximeng; Wu, Xi; Lluch Lafuente, Alberto

    2017-01-01

    We present a coordination language for the modeling of distributed database applications. The language, baptized Klaim-DB, borrows the concepts of localities and nets of the coordination language Klaim but re-incarnates the tuple spaces of Klaim as databases. It provides high-level abstractions...... in the semantics. The use of the language is illustrated in a scenario where the sales from different branches of a chain of department stores are aggregated from their local databases. Raising the abstraction level and encapsulating integrity checks in the language primitives have benefited the modeling task...

  9. Other Special Waste

    DEFF Research Database (Denmark)

    Brogaard, Line Kai-Sørensen; Christensen, Thomas Højlund

    2011-01-01

    separately from MSW. Some of these other special wastes are briefly described in this chapter with respect to their definition, quantity and composition, and management options. The special wastes mentioned here are batteries, tires, polyvinylchloride (PVC) and food waste.......In addition to the main types of special waste related to municipal solid waste (MSW) mentioned in the previous chapters (health care risk waste, WEEE, impregnated wood, hazardous waste) a range of other fractions of waste have in some countries been defined as special waste that must be handled...

  10. Other Special Waste

    DEFF Research Database (Denmark)

    Brogaard, Line Kai-Sørensen; Christensen, Thomas Højlund

    2011-01-01

    In addition to the main types of special waste related to municipal solid waste (MSW) mentioned in the previous chapters (health care risk waste, WEEE, impregnated wood, hazardous waste) a range of other fractions of waste have in some countries been defined as special waste that must be handled...... separately from MSW. Some of these other special wastes are briefly described in this chapter with respect to their definition, quantity and composition, and management options. The special wastes mentioned here are batteries, tires, polyvinylchloride (PVC) and food waste....

  11. The Fluid-Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years.

    Science.gov (United States)

    Nicolson, Garth L

    2014-06-01

    In 1972 the Fluid-Mosaic Membrane Model of membrane structure was proposed based on thermodynamic principals of organization of membrane lipids and proteins and available evidence of asymmetry and lateral mobility within the membrane matrix [S. J. Singer and G. L. Nicolson, Science 175 (1972) 720-731]. After over 40years, this basic model of the cell membrane remains relevant for describing the basic nano-structures of a variety of intracellular and cellular membranes of plant and animal cells and lower forms of life. In the intervening years, however, new information has documented the importance and roles of specialized membrane domains, such as lipid rafts and protein/glycoprotein complexes, in describing the macrostructure, dynamics and functions of cellular membranes as well as the roles of membrane-associated cytoskeletal fences and extracellular matrix structures in limiting the lateral diffusion and range of motion of membrane components. These newer data build on the foundation of the original model and add new layers of complexity and hierarchy, but the concepts described in the original model are still applicable today. In updated versions of the model more emphasis has been placed on the mosaic nature of the macrostructure of cellular membranes where many protein and lipid components are limited in their rotational and lateral motilities in the membrane plane, especially in their natural states where lipid-lipid, protein-protein and lipid-protein interactions as well as cell-matrix, cell-cell and intracellular membrane-associated protein and cytoskeletal interactions are important in restraining the lateral motility and range of motion of particular membrane components. The formation of specialized membrane domains and the presence of tightly packed integral membrane protein complexes due to membrane-associated fences, fenceposts and other structures are considered very important in describing membrane dynamics and architecture. These structures along

  12. 7 CFR 22.201 - Coordination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Coordination. 22.201 Section 22.201 Agriculture Office of the Secretary of Agriculture RURAL DEVELOPMENT COORDINATION Roles and Responsibilities of Federal Government § 22.201 Coordination. The following identifies types and levels of coordination: (a) Washington...

  13. 15 CFR 923.56 - Plan coordination.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Plan coordination. 923.56 Section 923... COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Coordination, Public Involvement and National Interest § 923.56 Plan coordination. (a) The management program must be coordinated with local, areawide,...

  14. 40 CFR 109.6 - Coordination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Coordination. 109.6 Section 109.6..., LOCAL AND REGIONAL OIL REMOVAL CONTINGENCY PLANS § 109.6 Coordination. For the purposes of coordination... coordination of these contingency plans with the National Oil and Hazardous Materials Pollution...

  15. 29 CFR 42.8 - Coordination plan.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Coordination plan. 42.8 Section 42.8 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.8 Coordination plan. (a) Based upon, among other things, the... coordination plan concerning farm labor-related responsibilities of the Department, including migrant housing...

  16. 33 CFR 165.8 - Geographic coordinates.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Geographic coordinates. 165.8... Geographic coordinates. Geographic coordinates expressed in terms of latitude or longitude, or both, are not... 1983 (NAD 83), unless such geographic coordinates are expressly labeled NAD 83. Geographic...

  17. The Convex Coordinates of the Symmedian Point

    Science.gov (United States)

    Boyd, J. N.; Raychowdhury, P. N.

    2006-01-01

    In this note, we recall the convex (or barycentric) coordinates of the points of a closed triangular region. We relate the convex and trilinear coordinates of the interior points of the triangular region. We use the relationship between convex and trilinear coordinates to calculate the convex coordinates of the symmedian point of the triangular…

  18. 78 FR 73819 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-12-09

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of...-18, 2013 meeting of the Forest Resource Coordinating Committee due to the Government partial shutdown... INFORMATION CONTACT: Maya Solomon, Forest Resource Coordinating Committee Program Coordinator; by phone at...

  19. 76 FR 82299 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Data...

    Science.gov (United States)

    2011-12-30

    ... to ``Data Coordinating Center for Autism and Other Developmental Disabilities Research and... Control Special Emphasis Panel (SEP): Data Coordinating Center for Autism and Other Developmental Disabilities Research and Epidemiologic Studies, RFA DD12-001, Initial Review In accordance with Section...

  20. Planning for the Special Needs of the Homeless Elderly.

    Science.gov (United States)

    Doolin, Joseph

    1986-01-01

    The special needs of the homeless elderly are discussed, followed by the presentation of a program designed to augment the work of public shelters by coordinating medical, nutrition, and social services in a day center format that is structurally integrated within the local aging service infrastructure, utilizing existing resource patterns.…

  1. Internationally coordinated glacier monitoring: strategy and datasets

    Science.gov (United States)

    Hoelzle, Martin; Armstrong, Richard; Fetterer, Florence; Gärtner-Roer, Isabelle; Haeberli, Wilfried; Kääb, Andreas; Kargel, Jeff; Nussbaumer, Samuel; Paul, Frank; Raup, Bruce; Zemp, Michael

    2014-05-01

    Internationally coordinated monitoring of long-term glacier changes provide key indicator data about global climate change and began in the year 1894 as an internationally coordinated effort to establish standardized observations. Today, world-wide monitoring of glaciers and ice caps is embedded within the Global Climate Observing System (GCOS) in support of the United Nations Framework Convention on Climate Change (UNFCCC) as an important Essential Climate Variable (ECV). The Global Terrestrial Network for Glaciers (GTN-G) was established in 1999 with the task of coordinating measurements and to ensure the continuous development and adaptation of the international strategies to the long-term needs of users in science and policy. The basic monitoring principles must be relevant, feasible, comprehensive and understandable to a wider scientific community as well as to policy makers and the general public. Data access has to be free and unrestricted, the quality of the standardized and calibrated data must be high and a combination of detailed process studies at selected field sites with global coverage by satellite remote sensing is envisaged. Recently a GTN-G Steering Committee was established to guide and advise the operational bodies responsible for the international glacier monitoring, which are the World Glacier Monitoring Service (WGMS), the US National Snow and Ice Data Center (NSIDC), and the Global Land Ice Measurements from Space (GLIMS) initiative. Several online databases containing a wealth of diverse data types having different levels of detail and global coverage provide fast access to continuously updated information on glacier fluctuation and inventory data. For world-wide inventories, data are now available through (a) the World Glacier Inventory containing tabular information of about 130,000 glaciers covering an area of around 240,000 km2, (b) the GLIMS-database containing digital outlines of around 118,000 glaciers with different time stamps and

  2. Point-like inclusion interactions in tubular membranes

    CERN Document Server

    Vahid, Afshin

    2015-01-01

    We analytically study membrane mediated interactions between inclusions embedded in a tubular membrane. We model inclusions as constraints coupled to the curvature tensor of the membrane tube. First, as special test cases, we analyze the interaction between ring and rod shaped inclusions. Using Monte Carlo simulations, we further show how point-like inclusions interact to form linear aggregates. Our results reveal that depending on the hard-core radius of the inclusions, they arrange into either lines or rings to globally minimize the curvature energy of the membrane.

  3. Remove volatile organic compounds (VOCs) with membrane separation techniques

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Membrane separation, a new technology for removing VOCs including pervaporation, vapor permeation, membrane contactor, and membrane bioreactor was presented. Comparing with traditional techniques, these special techniques are an efficient and energy-saving technology. Vapor permeation can be applied to recovery of organic solvents from exhaust streams. Membrane contactor could be used for removing or recovering VOCs from air or wastewater. Pervaporation and vapor permeation are viable methods for removing VOCs from wastewater to yield a VOC concentrate which could either be destroyed by conventional means, or be recycled for reuse.

  4. Coordination Frictions and Job Heterogeneity

    DEFF Research Database (Denmark)

    Kennes, John; le Maire, Christian Daniel

    This paper develops and extends a dynamic, discrete time, job to worker matching model in which jobs are heterogeneous in equilibrium. The key assumptions of this economic environment are (i) matching is directed and (ii) coordination frictions lead to heterogeneous local labor markets. We de- rive...

  5. Terrestrial Coordinate Systems and Frames

    Science.gov (United States)

    Boucher, C.; Murdin, P.

    2000-11-01

    A terrestrial reference system (TRS) is a spatial reference system corotating with the Earth in its DIURNAL MOTION in space. In such a system, the positions of points anchored on the Earth's solid surface have coordinates which have only small variations with time, as a result of geophysical effects (tectonic or tidal deformations; see TECTONICS, EARTH'S INTERIOR, TIDES). A terrestrial reference ...

  6. Archimedes' Principle in General Coordinates

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is…

  7. Coordinated Exploration for Grand Challenges

    DEFF Research Database (Denmark)

    Ørding Olsen, Anders; Sofka, Wolfgang; Grimpe, Christoph

    2016-01-01

    on the acceptance and support of important stakeholders. In this study, we suggest that search consortia are more likely to receive funding when they include representatives of stakeholder concerns, so-called advocacy groups. We extend theory on coordinated exploration in joint search by integrating mechanisms from...

  8. Coordinating talk and practical action

    DEFF Research Database (Denmark)

    Oshima, Sae; Streeck, Jürgen

    2015-01-01

    This paper investigates how talk and practical action are coordinated during one type of activity involving professional communication: the service-assessment sequence in hair salons. During this activity, a practical inspection of the haircut must be coupled with sequentially produced verbal act...

  9. Archimedes' Principle in General Coordinates

    Science.gov (United States)

    Ridgely, Charles T.

    2010-01-01

    Archimedes' principle is well known to state that a body submerged in a fluid is buoyed up by a force equal to the weight of the fluid displaced by the body. Herein, Archimedes' principle is derived from first principles by using conservation of the stress-energy-momentum tensor in general coordinates. The resulting expression for the force is…

  10. Coordinating talk and practical action

    DEFF Research Database (Denmark)

    Oshima, Sae; Streeck, Jürgen

    2015-01-01

    . Our analysis of four examples reveals that there is no fixed relationship between the organization of talk and practical action. Instead, people manipulate this relationship on a moment-by-moment basis, often coordinating the two into a single, integral package, or relying on one stream of action...

  11. Early insulin therapy Coordination Council

    Directory of Open Access Journals (Sweden)

    Marina Vladimirovna Shestakova

    2012-12-01

    Full Text Available Coordination Council has denoted the importance of adherence to Russian and international guidelines and prominent role of insulin therapy in management of type 2 diabetes mellitus (T2DM. Insulin therapy in T2DM preserves endogenous insulin secretion, prevents or decelerates development of microvascular complications and is known to be the most effective glucose-lowering treatment.

  12. The Big Special Stage

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The 2007 Special Olympics World Summer Games have brought a change of attitude toward the mentally challenged No one would imagine that there could be any connection between the 1.65-meter skinny Wu Fangmiao and basketball. Actually,the short boy with cere- bral palsy is a basketball ace at the Special Olympics in Shanghai.

  13. New Special Finsler Spaces

    CERN Document Server

    Youssef, Nabil L

    2016-01-01

    The pullback approach to global Finsler geometry is adopted. Some new types of special Finsler spaces are introduced and investigated, namely, Ricci, generalized Ricci, projectively recurrent and m-projectively recurrent Finsler spaces. The properties of these special Finsler spaces are studied and the relations between them are singled out.

  14. Special Education in Jordan

    Science.gov (United States)

    Abu-Hamour, Bashir; Al-Hmouz, Hanan

    2014-01-01

    The purpose of this article is to provide a brief background about special education system in Jordan and particularly describes the present types of programmes and legislation provided within the country to students with special needs, as well as integration movement. Jordan has historically provided a limited number of educational opportunities…

  15. Postmodernism in Special Education.

    Science.gov (United States)

    Gerber, Michael M.

    1994-01-01

    This paper urges special educators to be wary of borrowing fashionable rhetoric of postmodernism to justify constructivism in the reform of instruction and curriculum without disentangling accompanying constructs and values. There are higher stakes for special education, particularly in national curriculum and testing reform, that accompany…

  16. Keeping Special Forces Special: Regional Proficiency in Special Forces

    Science.gov (United States)

    2011-12-01

    than one month IOT allow Soldiers to listen to the language, conduct travel/recon etc. —Special Forces Soldier294 Immersion is the third method by...incentive lower. Conversely, a person with a lower interest in regional proficiency would rate the incentive higher. Variable Mean Std Dev Regional...Variable Mean Std Dev Regional Proficiency Interest 6.29 .99 Command Environment Value 4.41 1.62 PDSI 2.54 1.60 Promotion 2.92 1.62 153

  17. Membrane Automata with Priorities

    Institute of Scientific and Technical Information of China (English)

    Luděk Cienciala; Lucie Ciencialová

    2004-01-01

    In this paper the one-way P automata with priorities are introduced. Such automata are P systemshere the membranes are only allowed to consume objects from parent membranes, under the given conditions. The result of computation of these systems is the set of multiset sequences consumed by skin membrane intc the system. The rules associated in some order with each membrane cannot modify any objects, they can only move them through membrane. We show that P automata with priorities and two membranes can accept every recursively enumerated language.

  18. Quipus and System of Coordinated Precession

    Science.gov (United States)

    Campos, T. C.

    2004-05-01

    The Incas of ancient Peru possessed no writing. Instead, they developed a unique system expressed on spatial arrays of colored knotted cords called Quipus to record and transmit information throughout their vast empire. In their thorough description of quipus, Ascher & Ascher observed that in two cases the numbers registered in their strings have a very special relationship to each other. For this to occur the numbers must have been obtained through the multiplication of whole numbers by fractions or decimals, operations apparently beyond the arithmetic knowledge of the Incas. The quipus AS120 and AS143, coming from Ica (Peru) and conserved in the Museum of Berlin has the suitable characteristics previously. In the AS143 there is a the relationship with the systems of coordinated precession (tilt of Earth's spin axis (40036); eccentricity of Earth's orbit (97357); and precession of equinoxes (between 18504 and 23098)). For the history of the Earth are necessary an chronometer natural to coordinate and to classify the observations and this chronometer comes to be the vernal point, defining the vernal point as" a sensitive axis of maximum conductivity" as itdemonstrates it the stability of the geomagnetic equator (inclination of the field is zero grades), in the year 1939 calculated with the IGRF from the year 1900 up to the 2004 and that it is confirmed with tabulated data of the Geophysical Institute of Huancayo (Peru),from that date until this year (2004) and this fluctuating between the 12-14 South.,on the other hand in the area of Brazil it has advanced very quickly toward the north, and above to 108 km. approximately it is located the equatorial electrojet that is but intense in the equinoxes in South America. And this stability from the point of view of the precession of the equinoxes this coinciding with the entrance of the apparent sun for the constellation of Aquarius, being this mechanism the base to establish a system of coordinated precession where it is

  19. Experimental substantiation of methodic of 11-13 years old boxers’ coordination development

    Directory of Open Access Journals (Sweden)

    Liu Yong Qiang

    2015-06-01

    Full Text Available Purpose: experimental substantiation of methodic of junior boxers’ coordination training. Material: in the research 18 boxers of 11-13 year old age participated. In total, during 4 months 42 trainings were conducted. Total time of coordination load’s fulfillment at each training was 15-45 minutes. Results: dynamic of results in control tests was statistically confident in the tested parameters of movements. It proves effectiveness of usage the tasks with complex-coordination orientation, accented on impact on sensor-informational and motor systems of movements in junior boxers’ trainings. Conclusions: coordination training in boxing at initial stage shall include specialized varied means and methods, which would facilitate formation of motor condition and skills’ basis. Motor condition and skills are a reserve for further rising of coordination abilities’ level of junior sportsmen.

  20. Reaction coordinates, one-dimensional Smoluchowski equations, and a test for dynamical self-consistency.

    Science.gov (United States)

    Peters, Baron; Bolhuis, Peter G; Mullen, Ryan G; Shea, Joan-Emma

    2013-02-01

    We propose a method for identifying accurate reaction coordinates among a set of trial coordinates. The method applies to special cases where motion along the reaction coordinate follows a one-dimensional Smoluchowski equation. In these cases the reaction coordinate can predict its own short-time dynamical evolution, i.e., the dynamics projected from multiple dimensions onto the reaction coordinate depend only on the reaction coordinate itself. To test whether this property holds, we project an ensemble of short trajectory swarms onto trial coordinates and compare projections of individual swarms to projections of the ensemble of swarms. The comparison, quantified by the Kullback-Leibler divergence, is numerically performed for each isosurface of each trial coordinate. The ensemble of short dynamical trajectories is generated only once by sampling along an initial order parameter. The initial order parameter should separate the reactants and products with a free energy barrier, and distributions on isosurfaces of the initial parameter should be unimodal. The method is illustrated for three model free energy landscapes with anisotropic diffusion. Where exact coordinates can be obtained from Kramers-Langer-Berezhkovskii-Szabo theory, results from the new method agree with the exact results. We also examine characteristics of systems where the proposed method fails. We show how dynamical self-consistency is related (through the Chapman-Kolmogorov equation) to the earlier isocommittor criterion, which is based on longer paths.

  1. Special issue photovoltaic; Numero special photovoltaique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-05-01

    In this letter of the INES (french National Institute of the Solar Energy), a special interest is given to photovoltaic realizations in Europe. Many information are provided on different topics: the China future fifth world producer of cells in 2005, batteries and hydrogen to storage the solar energy and a technical sheet on a photovoltaic autonomous site installation for electric power production. (A.L.B.)

  2. Water vapor diffusion membrane development

    Science.gov (United States)

    Tan, M. K.

    1977-01-01

    An application of the water vapor diffusion technique is examined whereby the permeated water vapor is vented to space vacuum to alleviate on-board waste storage and provide supplemental cooling. The work reported herein deals primarily with the vapor diffusion-heat rejection (VD-HR) as it applies to the Space Shuttle. A stack configuration was selected, designed and fabricated. An asymmetric cellulose acetate membrane, used in reverse osmosis application was selected and a special spacer was designed to enhance mixing and promote mass transfer. A skid-mount unit was assembled from components used in the bench unit although no attempt was made to render it flight-suitable. The operating conditions of the VD-HR were examined and defined and a 60-day continuous test was carried out. The membranes performed very well throughout the test; no membrane rupture and no unusual flux decay was observed. In addition, a tentative design for a flight-suitable VD-HR unit was made.

  3. Mechanisms that underlie coordination in children with developmental coordination disorder.

    Science.gov (United States)

    O'Brien, Jane Clifford; Williams, Harriet G; Bundy, Anita; Lyons, Jim; Mittal, Amita

    2008-01-01

    The authors examined potential mechanisms underlying motor coordination in children with developmental coordination disorder (DCD). Because children with DCD experience difficulty processing visual, auditory, and vibrotactile information, the authors explored patterns of choice reaction time (RT) in young (6-7 years) and older (9-10 years) children with and without DCD by using a compatibility-incompatibility paradigm and different sensory modalities. Young children responded more slowly than older children to visual, auditory, and vibrotactile stimuli. Children with DCD took longer than typical children to process visual and vibrotactile stimuli under more complex stimulus-response mappings. Young children with DCD responded more slowly than typical children to visual and vibrotactile information under incompatible conditions. Children with DCD responded faster than unaffected children to auditory stimuli. The results suggest that there is a developmental nature in the processing of visual and auditory input and imply that the vibrotactile sensory modality may be key to the motor coordination difficulties of children with DCD.

  4. Solving Einstein's Equations With Dual Coordinate Frames

    CERN Document Server

    Scheel, M A; Lindblom, L; Pfeiffer, H P; Rinne, O; Teukolsky, S A; Kidder, Lawrence E.; Lindblom, Lee; Pfeiffer, Harald P.; Rinne, Oliver; Scheel, Mark A.; Teukolsky, Saul A.

    2006-01-01

    A method is introduced for solving Einstein's equations using two distinct coordinate systems. The coordinate basis vectors associated with one system are used to project out components of the metric and other fields, in analogy with the way fields are projected onto an orthonormal tetrad basis. These field components are then determined as functions of a second independent coordinate system. The transformation to the second coordinate system can be thought of as a mapping from the original ``inertial'' coordinate system to the computational domain. This dual-coordinate method is used to perform stable numerical evolutions of a black-hole spacetime using the generalized harmonic form of Einstein's equations in coordinates that rotate with respect to the inertial frame at infinity; such evolutions are found to be generically unstable using a single rotating coordinate frame. The dual-coordinate method is also used here to evolve binary black-hole spacetimes for several orbits. The great flexibility of this met...

  5. Scaling Up Coordinate Descent Algorithms for Large ℓ1 Regularization Problems

    Energy Technology Data Exchange (ETDEWEB)

    Scherrer, Chad; Halappanavar, Mahantesh; Tewari, Ambuj; Haglin, David J.

    2012-07-03

    We present a generic framework for parallel coordinate descent (CD) algorithms that has as special cases the original sequential algorithms of Cyclic CD and Stochastic CD, as well as the recent parallel Shotgun algorithm of Bradley et al. We introduce two novel parallel algorithms that are also special cases---Thread-Greedy CD and Coloring-Based CD---and give performance measurements for an OpenMP implementation of these.

  6. Laccase Immobilization by Chelated Metal Ion Coordination Chemistry

    Directory of Open Access Journals (Sweden)

    Qingqing Wang

    2014-09-01

    Full Text Available In this work, amidoxime polyacrylonitrile (AOPAN nanofibrous membrane was prepared by a reaction between PAN nanofibers and hydroxylamine hydrochloride. The AOPAN nanofibrous membranes were used for four metal ions (Fe3+, Cu2+, Ni2+, Cd2+ chelation under different conditions. Further, the competition of different metal ions coordinating with AOPAN nanofibrous membrane was also studied. The AOPAN chelated with individual metal ion (Fe3+, Cu2+, Ni2+, Cd2+ and also the four mixed metal ions were further used for laccase (Lac immobilization. Compared with free laccase, the immobilized laccase showed better resistance to pH and temperature changes as well as improved storage stability. Among the four individual metal ion chelated membranes, the stability of the immobilized enzymes generally followed the order as Fe–AOPAN–Lac > Cu–AOPAN–Lac > Ni–AOPAN–Lac > Cd–AOPAN–Lac. In addition, the immobilized enzyme on the carrier of AOPAN chelated with four mixed metal ions showed the best properties.

  7. Managing Coordinator, Educational or Entrepreneurial Coordinator: Course Coordinator Profile Analysis at Private HEIS

    Directory of Open Access Journals (Sweden)

    Mariana Augusta de Araújo Silva

    2014-12-01

    Full Text Available Higher Education dynamics is impacted by political, economic and financial interference. In parallel, the Ministry of Education and Culture (MEC is strict in its reviews to ensure Brazilian higher education is appreciated and promoted. The purpose of this study is to identify the profile of Course Coordinators and factors that might improve, at the surveyed HEIs, this professional´s relationship with students, teaching staff and Directors. Literature was searched and reviewed so as to collect subject matter pertaining issues. A quantitative research approach was employed and objectives were of exploratory descriptive nature since this technique ensures extended comprehension of the investigated phenomenon, whilst data was gathered via personal interviews. The object of investigation comprised all Course Coordinators of the Estácio/Natal Group in Brazil´s four units. The survey´s tool comprises: 13 closed questions to identify the Coordinator´s profile; 17 questions with a 5 point Likert score scale to identify the entrepreneurial profile; 42 also resorting to a 5 point Likert score scale to measure the dimensions of the Coordinator´s activities and 4 open, optional questions to measure difficulties and possibilities that impact the development of an entrepreneurial course management approach. The study employed both a statistical method (data analysis and descriptive statistics. Findings lead to the conclusion that information and knowledge gathered support researched HEIs in their overcoming of challenges, amongst which encouraging strategic course management and innovation, focused on implementing a new vision of the Course Coordinator, as professionals that master how to balance management and pedagogical skills, whilst innovating by resorting to entrepreneurial competencies.

  8. Composite zeolite membranes

    Science.gov (United States)

    Nenoff, Tina M.; Thoma, Steven G.; Ashley, Carol S.; Reed, Scott T.

    2002-01-01

    A new class of composite zeolite membranes and synthesis techniques therefor has been invented. These membranes are essentially defect-free, and exhibit large levels of transmembrane flux and of chemical and isotopic selectivity.

  9. Oxygen transport membrane

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a novel composite oxygen transport membrane as well as its preparation and uses thereof.......The present invention relates to a novel composite oxygen transport membrane as well as its preparation and uses thereof....

  10. Hybrid adsorptive membrane reactor

    Science.gov (United States)

    Tsotsis, Theodore T. (Inventor); Sahimi, Muhammad (Inventor); Fayyaz-Najafi, Babak (Inventor); Harale, Aadesh (Inventor); Park, Byoung-Gi (Inventor); Liu, Paul K. T. (Inventor)

    2011-01-01

    A hybrid adsorbent-membrane reactor in which the chemical reaction, membrane separation, and product adsorption are coupled. Also disclosed are a dual-reactor apparatus and a process using the reactor or the apparatus.

  11. Solvent resistant nanofiltration membranes

    OpenAIRE

    Dutczak, S.M.

    2011-01-01

    This thesis describes preparation and characterization of membranes for organic solvent filtration (OSF). The main aim was developing membranes for solvent resistant nanofiltration (SRNF) with molecular weight cut-off below 500 g mol-1.

  12. Transmembrane Signalling: Membrane messengers

    Science.gov (United States)

    Cockroft, Scott L.

    2017-05-01

    Life has evolved elaborate means of communicating essential chemical information across cell membranes. Inspired by biology, two new artificial mechanisms have now been developed that use synthetic messenger molecules to relay chemical signals into or across lipid membranes.

  13. Ionene membrane battery separator

    Science.gov (United States)

    Moacanin, J.; Tom, H. Y.

    1969-01-01

    Ionic transport characteristics of ionenes, insoluble membranes from soluble polyelectrolyte compositions, are studied for possible application in a battery separator. Effectiveness of the thin film of separator membrane essentially determines battery lifetime.

  14. Hybrid adsorptive membrane reactor

    Science.gov (United States)

    Tsotsis, Theodore T.; Sahimi, Muhammad; Fayyaz-Najafi, Babak; Harale, Aadesh; Park, Byoung-Gi; Liu, Paul K. T.

    2011-03-01

    A hybrid adsorbent-membrane reactor in which the chemical reaction, membrane separation, and product adsorption are coupled. Also disclosed are a dual-reactor apparatus and a process using the reactor or the apparatus.

  15. ORTHODONTIC MANAGEMENT IN CHILDREN WITH SPECIAL NEEDS

    Directory of Open Access Journals (Sweden)

    Adit ARORA

    2013-07-01

    Full Text Available Special needs individuals are children or adults pre‐ vented by a physical or mental condition permitting their full participation to the normal range of activities of their age groups. They usually exhibit high orthodontic treat‐ ment needs because of an increased prevalence and seve‐ rity of malocclusions. These conditions often require a coordinated craniofacial orthodontic and surgical treat‐ ment in a team setting, to achieve optimal outcome. Ort‐ hodontic treatments for patients born with facial differences tend to be more complex than ordinary ortho‐ dontics. This multidisciplinary treatment often starts from birth and extends up to the late teen years. The young patient may require treatment by multiple specialists, including a craniofacial surgeon, pediatrician, geneticist, neurosurgeon, ENT, speech and language therapist, pedi‐ atric dentist, oral surgeon and prosthodontist. The objec‐ tive of this paper is to summarize protocols of orthodontic treatment and to present various orthodontic management protocols regarding the children with special needs.

  16. Special theory of relativity

    CERN Document Server

    Kilmister, Clive William

    1970-01-01

    Special Theory of Relativity provides a discussion of the special theory of relativity. Special relativity is not, like other scientific theories, a statement about the matter that forms the physical world, but has the form of a condition that the explicit physical theories must satisfy. It is thus a form of description, playing to some extent the role of the grammar of physics, prescribing which combinations of theoretical statements are admissible as descriptions of the physical world. Thus, to describe it, one needs also to describe those specific theories and to say how much they are limit

  17. G protein-membrane interactions II: Effect of G protein-linked lipids on membrane structure and G protein-membrane interactions.

    Science.gov (United States)

    Casas, Jesús; Ibarguren, Maitane; Álvarez, Rafael; Terés, Silvia; Lladó, Victoria; Piotto, Stefano P; Concilio, Simona; Busquets, Xavier; López, David J; Escribá, Pablo V

    2017-09-01

    G proteins often bear myristoyl, palmitoyl and isoprenyl moieties, which favor their association with the membrane and their accumulation in G Protein Coupled Receptor-rich microdomains. These lipids influence the biophysical properties of membranes and thereby modulate G protein binding to bilayers. In this context, we showed here that geranylgeraniol, but neither myristate nor palmitate, increased the inverted hexagonal (HII) phase propensity of phosphatidylethanolamine-containing membranes. While myristate and palmitate preferentially associated with phosphatidylcholine membranes, geranylgeraniol favored nonlamellar-prone membranes. In addition, Gαi1 monomers had a higher affinity for lamellar phases, while Gβγ and Gαβγ showed a marked preference for nonlamellar prone membranes. Moreover, geranylgeraniol enhanced the binding of G protein dimers and trimers to phosphatidylethanolamine-containing membranes, yet it decreased that of monomers. By contrast, both myristate and palmitate increased the Gαi1 preference for lamellar membranes. Palmitoylation reinforced the binding of the monomer to PC membranes and myristoylation decreased its binding to PE-enriched bilayer. Finally, binding of dimers and trimers to lamellar-prone membranes was decreased by palmitate and myristate, but it was increased in nonlamellar-prone bilayers. These results demonstrate that co/post-translational G protein lipid modifications regulate the membrane lipid structure and that they influence the physico-chemical properties of membranes, which in part explains why G protein subunits sort to different plasma membrane domains. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Content and structure of program developing the coordinating abilities of 10-13 years girls going in for calisthenics

    Directory of Open Access Journals (Sweden)

    Belokopitova J.A.

    2010-06-01

    Full Text Available The analysis of on-line tutorial is conducted for child-youth sporting schools and schools of olympic reserve. The moments of value of co-ordinating capabilities which influence on the technique of domain objects are marked. The developed program of development of co-ordinating capabilities of girls comes into question 10-13 years. The exemplary chart of distributing of time is offered on general and special co-ordinating preparation. The chart of trainings facilities of development of co-ordinating capabilities is developed

  19. Supply Chain Reorganization and Coordination

    Institute of Scientific and Technical Information of China (English)

    WANG Feng-bin

    2001-01-01

    Three generic forms of governance--hierarchy, hybrid and market are proposed in the newinstitutional economics, giving an abstract description of alternative coordination and control mechanisms forgeneral use. While this theory is known as far away from being operational and specified, a few researchersin the management and organization area are trying to extend Galbraith and/or Mintzberg's organizationaldesign theories into the application of logistical coordination for obtaining a smooth flow of products along thesupply chain within and without the focal organization. In this paper, we present an explorative case study onthe design of various organizational architectures of logistics activities and their relevant coordinationmechanisms, especially internal and external contracts as one new kind of hybrid mechanisms forcoordinating effective supply chains.

  20. [Transplant coordinator: organ donation process].

    Science.gov (United States)

    Gironés-Guillem, Purificación; Camaño-Puig, Ramón; Lillo-Crespo, Manuel

    2014-01-01

    Spain is a leader in organ donations although it seems that this number does not increase in the same proportion that the waiting list and it is necessary to decrease the refusal situations, which are ~16%. Analytic study. We review the reports prepared by the coordinators of transplants archived at the hospital La Fe during the period between May 1, 2004 and December 31, 2007, resulting in conceptualization and categorization. Sixty-nine topics were obtained from the point of view of the family and 11 from the point of view of the interviewer. After its conceptualization, codification and classification, we proceeded to create an appropriate text. Certain guidelines may be offered that allow us to standardize the action of transplant coordinators during the interview and to be more effective.

  1. TURNAROUND COORDINATOR. YES OR NOT?

    Directory of Open Access Journals (Sweden)

    Martin HROMÁDKA

    2013-12-01

    Full Text Available Both low cost carriers ‘fresh wind’ and liberalisation of ground handling market makes airlines to be cost-wise in every single field. Thus, ground handling contract are cutting down in terms of their costs. Handling companies struggle with pressure being put from the market environment, they rush 25 minutes turnaround with couple of people. This can be potentially dangerous from the safety point of view. One of possible solutions seems to be introducing turnaround coordinator, person who would supervise the ramp handling procedures. This paper discusses the role of turnaround coordinator within the aircraft turnaround process. Duties and responsibilities of this person are described. However, not every airport is staffing this position. The survey shows that smaller airports pay much more attention to this issue than the big ones.

  2. Porphyrin coordination polymer nanospheres and nanorods

    Science.gov (United States)

    Wang, Zhongchun; Shelnutt, John A.; Medforth, Craig J.

    2012-12-04

    A porphyrin coordination polymer nanostructure comprising a network of pyridyl porphyrin molecules and coordinating metal ions coordinatively bound through the pyridyl groups. In some embodiments, the porphyrins are metalloporphyrins. A variety of nanostructures are formed by the network polymer, including nanospheres, polygonal nanostructures, nanorods, and nanofibers, depending on a variety of factors including coordination metal ion, porphyrin type, metal of the metalloporphyrin, and degree of agitation during nanostructure formation. Reduction of coordinating metal ions may be used to form metal nanoparticles on the coordination polymer nanostructure.

  3. Porphyrin coordination polymer nanospheres and nanorods

    Science.gov (United States)

    Wang, Zhongchun; Shelnutt, John A.; Medforth, Craig J.

    2013-09-10

    A porphyrin coordination polymer nanostructure comprising a network of pyridyl porphyrin molecules and coordinating metal ions coordinatively bound through the pyridyl groups. In some embodiments, the porphyrins are metalloporphyrins. A variety of nanostructures are formed by the network polymer, including nanospheres, polygonal nanostructures, nanorods, and nanofibers, depending on a variety of factors including coordination metal ion, porphyrin type, metal of the metalloporphyrin, and degree of agitation during nanostructure formation. Reduction of coordinating metal ions may be used to form metal nanoparticles on the coordination polymer nanostructure.

  4. How wet should be the reaction coordinate for ligand unbinding?

    CERN Document Server

    Tiwary, Pratyush

    2016-01-01

    We use a recently proposed method called Spectral Gap Optimization of Order Parameters (SGOOP) (Tiwary and Berne, Proc. Natl. Acad. Sci 2016, 113, 2839 (2016)), to determine an optimal 1-dimensional reaction coordinate (RC) for the unbinding of a bucky-ball from a pocket in explicit water. This RC is estimated as a linear combination of the multiple available order parameters that collectively can be used to distinguish the various stable states relevant for unbinding. We pay special attention to determining and quantifying the degree to which water molecules should be included in the RC. Using SGOOP with under-sampled biased simulations, we predict that water plays a distinct role in the reaction coordinate for unbinding in the case when the ligand is sterically constrained to move along an axis of symmetry. This prediction is validated through extensive calculations of the unbinding times through metadynamics, and by comparison through detailed balance with unbiased molecular dynamics estimate of the bindin...

  5. The coordination of regional interest in developing river basin

    Institute of Scientific and Technical Information of China (English)

    Chen Xiangman

    2006-01-01

    River basin is a special region with the characteristics of entirety and relation, regionality and diversity,gradation and network, openness and dissipation etc. It is an important unit that organizes and governs national economy as well as a natural region. In river basin, all natural essential factors relate closely each other, and there is remarkable influence between inter-regions. In the process of developing river basin, the multiplex main interest body,the diverse interest demand and the multi-ways of interest realization constitute a complicated interest network, and result in various contradictions and conflicts. Therefore, effective regional interest coordination mechanism should be established to coordinate various regional interest relations. They are the public interest realization mechanism, the fair interest assignment mechanism, the effective interest integration mechanism, the expedited interest expression mechanism and the reasonable interest compensative mechanism.

  6. The actin homologue MreB organizes the bacterial cell membrane

    NARCIS (Netherlands)

    Strahl, H.; Burmann, F.; Hamoen, L.W.

    2014-01-01

    The eukaryotic cortical actin cytoskeleton creates specific lipid domains, including lipid rafts, which determine the distribution of many membrane proteins. Here we show that the bacterial actin homologue MreB displays a comparable activity. MreB forms membrane-associated filaments that coordinate

  7. Catalytic membrane-installed microchannel reactors for one-second allylic arylation.

    Science.gov (United States)

    Yamada, Yoichi M A; Watanabe, Toshihiro; Torii, Kaoru; Uozumi, Yasuhiro

    2009-10-07

    A variety of catalytic membranes of palladium-complexes with linear polymer ligands were prepared inside a microchannel reactor via coordinative and ionic molecular convolution to provide catalytic membrane-installed microdevices, which were applied to the instantaneous allylic arylation reaction of allylic esters and aryl boron reagents under microflow conditions to afford the corresponding coupling products within 1 second of residence time.

  8. Resolution enhancement in tilted coordinates

    Science.gov (United States)

    Hariri Naghadeh, Diako; Keith Morley, Christopher

    2016-11-01

    Deconvolution is applied to remove source wavelet effects from seismograms. The results are resolution enhancement that enables detection of thin layers. Following enhancement of resolution, low frequency and high angle reflectors, particularly at great depth, appear as low amplitude and semi-invisible reflectors that are difficult to track and pick. A new approach to enhance resolution is introduced that estimates a derivative using continuous wavelet transform in tilted coordinates. The results are compared with sparse spike deconvolution, curvelet deconvolution and inverse quality filtering in wavelet domain. The positive consequence of the new method is to increase sampling of high dip features by changing the coordinate system from Cartesian to tilted. To compare those methods a complex data set was chosen that includes high angle faults and chaotic mass transport complex. Image enhancement using curvelet deconvolution shows a chaotic system as a non-chaotic one. The results show that sparse spike deconvolution and inverse quality filtering in wavelet domain are able to enhance resolution more than curvelet deconvolution especially at great depth but it is impossible to follow steep dip reflectors after resolution enhancement using these methods, especially when their apparent dips are more than 45°. By estimating derivatives in a continuous wavelet transform from tilted data sets similar resolution enhancement as the other deconvolution methods is achieved but additionally steep dipping reflectors are imaged much better than others. Subtracted results of the enhanced resolution data set using new method and the other introduced methods show that steeply dipping reflectors are highlighted as a particular ability of the new method. The results show that high frequency recovery in Cartesian co-ordinate is accompanied by inability to image steeply dipping reflectors especially at great depths. Conversely recovery of high frequency data and imaging of the data

  9. DEVELOPMENTAL COORDINATION DISORDER IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Saeideh MIRAFKHAMI

    2010-04-01

    Full Text Available ObjectiveIn this article, a motor skill disorder called developmental coordination disorder (DCD, that is usually first diagnosed during childhood, is explained and discussed. In the year 1987, DCD was formally recognized as a distinct disorder in children by the American Psychiatric Association  (APA. DCD is a generalized term for the children who have some degrees of impairment in the development of motor coordination and therefore have difficulties with physical skills which significantly interfere with their academic achievements and /or performing everyday activities. As they develop, other age-related tasks are also below average. Because these impairment & conditions are often associated with emotional distress, they can seriously interfere with the person's everyday life and social relationships. Reviews indicate that most of the training rocedures have only a limited effect on the development of general coordination, and that they have no effect at all on academic progress.This includes approaches based on assumed underlying deficiencies such as sensory integration deficits and kinesthetic functioning deficits, as well as the more traditional perceptual - motor training. One new approach is Cognitive Orientation to daily Occupational Performance (CO-OP, based on problem - solving strategies and guided discovery of the child and task specific strategies. The aim of this article was to inform, promote and disseminate more information about some difficulties in applying the diagnostic criteria for DCD. Also, a brief review of the researches on the intervention methods is presented.Keywords: Developmental coordination disorder, Motor skills disorder, Childhood disorder, Intervention methods

  10. Coordination strategies of crew management

    Science.gov (United States)

    Conley, Sharon; Cano, Yvonne; Bryant, Don

    1991-01-01

    An exploratory study that describes and contrasts two three-person flight crews performing in a B-727 simulator is presented. This study specifically attempts to delineate crew communication patterns accounting for measured differences in performance across routine and nonroutine flight patterns. The communication patterns in the two crews evaluated indicated different modes of coordination, i.e., standardization in the less effective crew and planning/mutual adjustment in the more effective crew.

  11. Coordination strategies of crew management

    Science.gov (United States)

    Conley, Sharon; Cano, Yvonne; Bryant, Don

    1991-01-01

    An exploratory study that describes and contrasts two three-person flight crews performing in a B-727 simulator is presented. This study specifically attempts to delineate crew communication patterns accounting for measured differences in performance across routine and nonroutine flight patterns. The communication patterns in the two crews evaluated indicated different modes of coordination, i.e., standardization in the less effective crew and planning/mutual adjustment in the more effective crew.

  12. Membrane contactor applications

    NARCIS (Netherlands)

    Klaassen, R.; Feron, P.H.M.; Jansen, A.

    2008-01-01

    In a membrane contactor the membrane separation is completely integrated with an extraction or absorption operation in order to exploit the benefits of both technologies fully. Membrane contactor applications that have been developed can be found in both water and gas treatment. Several recently dev

  13. On "spinning" membrane models

    NARCIS (Netherlands)

    Bergshoeff, E.; Sezgin, E.; Townsend, P.K.

    1988-01-01

    Several alternative actions for a bosonic membrane have recently been proposed. We show that a linearly realized locally world-volume-supersymmetric (spinning membrane) extension of any of these actions implies an analogous extension of the standard Dirac membrane action. We further show that a

  14. Coordinate unsaturation with fluorinated ligands

    Energy Technology Data Exchange (ETDEWEB)

    Rack, J.L.; Hurlburt, P.K.; Anderson, O.P.; Strauss, S.H. [Colorado State Univ., Ft. Collins, CO (United States)

    1993-12-31

    The preparation and characterization of Zn(OTeF{sub 5}){sub 2} has resulted in a model compound with which to explore the concept of coordinative unsaturation. The coordination of solvents of varying donicity and dielectric constant to the Zn(II) ions in Zn(OTeF{sub 5}){sub 2} was studied by vapor phase monometry, NMR and IR spectroscopy, conductimetry, and X-Ray crystallography. The structures of [Zn(C{sub 6}H{sub 5}NO{sub 2}){sub 2}(OTeF{sub 5})2]2 and Zn(C{sub 6}H{sub 5}NO{sub 2}){sub 3}(OTEF{sub 5}){sub 2} demonstrate the electronic flexibility of some weakly coordinating solvents in that nitrobenzene can function as either an {eta}{sup 1}O or {eta}{sup 2}O,O`-ligand. The dependence of the number of bound solvent molecules and the degree of OTeF{sub 5}{minus} dissociation on solvent donor number and dielectric constant will be presented.

  15. DEVELOPMENTAL COORDINATION DISORDER IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Saeideh MIRAFKHAMI

    2010-03-01

    Full Text Available ObjectiveIn this article, a motor skill disorder called developmental coordination disorder (DCD, that is usually first diagnosed during childhood, is explained and discussed. In the year 1987, DCD was formally recognized as a distinct disorder in children by the American Psychiatric Association (APA. DCD is a generalized term for the children who have some degrees of impairment in the development of motor coordination and therefore have difficulties with physical skills which significantly interfere with their academic achievements and /or performing everyday activities. As they develop, other age-related tasks are also below average. Because these impairment & conditions are often associated with emotional distress, they can seriously interfere with the person's everyday life and social relationships. Reviews indicate that most of the training rocedures have only a limited effect on the development of general coordination, and that they have no effect at all on academic progress.This includes approaches based on assumed underlying deficiencies such as sensory integration deficits and kinesthetic functioning deficits, as well as the more traditional perceptual - motor training. One new approach is Cognitive Orientation to daily Occupational Performance (CO-OP, based on problem - solving strategies and guided discovery of the child and task specific strategies. The aim of this article was to inform, promote and disseminate more information about some difficulties in applying the diagnostic criteria for DCD. Also, a brief review of the researches on the intervention methods is presented.

  16. Transport of Carbon Dioxide through a Biomimetic Membrane

    Directory of Open Access Journals (Sweden)

    Efstathios Matsaridis

    2011-01-01

    Full Text Available Biomimetic membranes (BMM based on polymer filters impregnated with lipids or their analogues are widely applied in numerous areas of physics, biology, and medicine. In this paper we report the design and testing of an electrochemical system, which allows the investigation of CO2 transport through natural membranes such as alveoli barrier membrane system and also can be applied for solid-state measurements. The experimental setup comprises a specially designed two-compartment cell with BMM connected with an electrochemical workstation placed in a Faraday cage, two PH meters, and a nondispersive infrared gas analyzer. We prove, experimentally, that the CO2 transport through the natural membranes under different conditions depends on pH and displays a similar behavior as natural membranes. The influence of different drugs on the CO2 transport process through such membranes is discussed.

  17. Fabrication of Polybenzimidazole/Palladium Nanoparticles Hollow Fiber Membranes for Hydrogen Purification

    KAUST Repository

    Villalobos, Luis Francisco

    2017-09-13

    A novel scheme to fabricate polybenzimidazole (PBI) hollow fiber membranes with a thin skin loaded with fully dispersed palladium nanoparticles is proposed for the first time. Palladium is added to the membrane during the spinning process in the form of ions that coordinate to the imidazole groups of the polymer. This is attractive for membrane production because agglomeration of nanoparticles is minimized and the high-cost metal is incorporated in only the selective layer—where it is required. Pd-containing membranes achieve three orders of magnitude higher H2 permeances and a twofold improvement in H2/CO2 selectivity compared to pure PBI hollow fiber membranes.

  18. Special issue: Plasma Conversion

    NARCIS (Netherlands)

    Nozaki, T.; Bogaerts, A.; Tu, X.; van de Sanden, M. C. M.

    2017-01-01

    With growing concern of energy and environmental issues, the combination of plasma and heterogeneous catalysts receives special attention in greenhouse gas conversion, nitrogen fixation and hydrocarbon chemistry. Plasma gas conversion driven by renewable electricity is particularly important for the

  19. Trout Stream Special Regulations

    Data.gov (United States)

    Minnesota Department of Natural Resources — This layer shows Minnesota trout streams that have a special regulation as described in the 2006 Minnesota Fishing Regulations. Road crossings were determined using...

  20. History of Special English

    Institute of Scientific and Technical Information of China (English)

    贾庆文

    2004-01-01

    On October 19, 1959, the first Special English program was broadcast on the Voice of America. It was an experiment. The goal was to communicate by radio in clear and simple English with people whose native lan-

  1. FWS Special Designation Areas

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the Special Designations that have been placed upon the lands and waters administered by the U.S. Fish and Wildlife Service (USFWS) in North...

  2. FWS Special Designation Areas

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the Special Designations that have been placed upon the lands and waters administered by the U.S. Fish and Wildlife Service (USFWS) in North...

  3. Research Article Special Issue

    African Journals Online (AJOL)

    2016-07-16

    Jul 16, 2016 ... foster talent, to improve public and specialized awareness, and to determine the strategies ... employees' performance but also their personality. ..... to be innovative, and motivating employees to produce knowledge. ... Spritzer, G, Psychological empowerment in the workplace: Dimensions, Measurement.

  4. Specialized Investment Services

    Science.gov (United States)

    Burgess, Robert S.

    1970-01-01

    The informational needs of the investing public should be met by the public library. Suggestions for specialized investment information services with broad appeal, technical charts, and advisory services which public libraries might consider purchasing. (JS)

  5. Effect of membrane length, membrane resistance, and filtration conditions on the fractionation of milk proteins by microfiltration.

    Science.gov (United States)

    Piry, A; Heino, A; Kühnl, W; Grein, T; Ripperger, S; Kulozik, U

    2012-04-01

    We investigated the fractionation of casein micelles and the whey protein β-lactoglobulin (β-LG) of skim milk by crossflow microfiltration (0.1 μm) for the first time by a novel approach as a function of membrane length and membrane resistance. A special module was constructed with 4 sections and used to assess the effects of membrane length by measuring flux and β-LG permeation (or transmission) as a function of transmembrane pressure and membrane length. Depending on the position, the membranes were partly controlled by a deposit layer. A maximum for β-LG mass flow through the various membrane sections was found, depending on the position along the membrane. To study the effect of convective flow toward the membrane, membranes with 4 different intrinsic permeation resistances were assessed in terms of the permeation and fouling effects along the flow channel. From these findings, we derived a ratio between transmembrane pressure and membrane resistance, which was useful in reducing the effect of deposit formation and, thus, to optimize the protein permeation. In addition, the fouling effect was investigated in terms of reversible and irreversible fouling and, in addition, by differentiation between pressure-induced fouling and adsorption-induced (pressure-independent) fouling, again as a function of membrane length.

  6. HPV Genotyping 9G Membrane Test

    Directory of Open Access Journals (Sweden)

    Danishmalik Rafiq Sayyed

    2013-11-01

    Full Text Available The results of the genital human papillomavirus (HPV detection in 439 cervical samples by cervical cytology were compared with sequencing analysis and a newly developed HPV genotyping 9G membrane test. The excellent sensitivity and specificity of the HPV genotyping 9G membrane test was assured by a signal to noise ratio of more than 300 and a target hybridization to non-target hybridization ratio of 300 ~ 400 at 25 °C. The final results can be obtained in 29 min by simple loading of the hybridization and washing solutions and scanning the membranes without any drying steps or special handling. The 100% identical results of the HPV genotyping 9G membrane test with sequencing results in 439 clinical samples demonstrate significant clinical application for this test. HPV genotyping 9G membrane tests can identify and discriminate five HR-HPV genotypes which are prevalent in almost 87% of cervical cancer cases. Its simple handling makes the HPV genotyping 9G membrane test a very convenient platform for accurate HPV genotyping.

  7. Tracking membrane protein association in model membranes.

    Directory of Open Access Journals (Sweden)

    Myriam Reffay

    Full Text Available Membrane proteins are essential in the exchange processes of cells. In spite of great breakthrough in soluble proteins studies, membrane proteins structures, functions and interactions are still a challenge because of the difficulties related to their hydrophobic properties. Most of the experiments are performed with detergent-solubilized membrane proteins. However widely used micellar systems are far from the biological two-dimensions membrane. The development of new biomimetic membrane systems is fundamental to tackle this issue.We present an original approach that combines the Fluorescence Recovery After fringe Pattern Photobleaching technique and the use of a versatile sponge phase that makes it possible to extract crucial informations about interactions between membrane proteins embedded in the bilayers of a sponge phase. The clear advantage lies in the ability to adjust at will the spacing between two adjacent bilayers. When the membranes are far apart, the only possible interactions occur laterally between proteins embedded within the same bilayer, whereas when membranes get closer to each other, interactions between proteins embedded in facing membranes may occur as well.After validating our approach on the streptavidin-biotinylated peptide complex, we study the interactions between two membrane proteins, MexA and OprM, from a Pseudomonas aeruginosa efflux pump. The mode of interaction, the size of the protein complex and its potential stoichiometry are determined. In particular, we demonstrate that: MexA is effectively embedded in the bilayer; MexA and OprM do not interact laterally but can form a complex if they are embedded in opposite bilayers; the population of bound proteins is at its maximum for bilayers separated by a distance of about 200 A, which is the periplasmic thickness of Pseudomonas aeruginosa. We also show that the MexA-OprM association is enhanced when the position and orientation of the protein is restricted by the

  8. Sport Specialization, Part I

    Science.gov (United States)

    Myer, Gregory D.; Jayanthi, Neeru; Difiori, John P.; Faigenbaum, Avery D.; Kiefer, Adam W.; Logerstedt, David; Micheli, Lyle J.

    2015-01-01

    Context: There is increased growth in sports participation across the globe. Sports specialization patterns, which include year-round training, participation on multiple teams of the same sport, and focused participation in a single sport at a young age, are at high levels. The need for this type of early specialized training in young athletes is currently under debate. Evidence Acquisition: Nonsystematic review. Study Design: Clinical review. Level of Evidence: Level 4. Conclusion: Sports specialization is defined as year-round training (greater than 8 months per year), choosing a single main sport, and/or quitting all other sports to focus on 1 sport. Specialized training in young athletes has risks of injury and burnout, while the degree of specialization is positively correlated with increased serious overuse injury risk. Risk factors for injury in young athletes who specialize in a single sport include year-round single-sport training, participation in more competition, decreased age-appropriate play, and involvement in individual sports that require the early development of technical skills. Adults involved in instruction of youth sports may also put young athletes at risk for injury by encouraging increased intensity in organized practices and competition rather than self-directed unstructured free play. Strength-of-Recommendation Taxonomy (SORT): C. PMID:26502420

  9. Separation membrane development

    Energy Technology Data Exchange (ETDEWEB)

    Lee, M.W. [Savannah River Technology Center, Aiken, SC (United States)

    1998-08-01

    A ceramic membrane has been developed to separate hydrogen from other gases. The method used is a sol-gel process. A thin layer of dense ceramic material is coated on a coarse ceramic filter substrate. The pore size distribution in the thin layer is controlled by a densification of the coating materials by heat treatment. The membrane has been tested by permeation measurement of the hydrogen and other gases. Selectivity of the membrane has been achieved to separate hydrogen from carbon monoxide. The permeation rate of hydrogen through the ceramic membrane was about 20 times larger than Pd-Ag membrane.

  10. Coordination of Passive Systems under Quantized Measurements

    NARCIS (Netherlands)

    De Persis, Claudio; Jayawardhana, Bayu

    2012-01-01

    In this paper we investigate a passivity approach to collective coordination and synchronization problems in the presence of quantized measurements and show that coordination tasks can be achieved in a practical sense for a large class of passive systems.

  11. Energy shaping for coordinating internally actuated vehicles

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    This paper considers the stable coordination problem of two vehicles equipping with internal moving mass actuators.The coordinating and stabilizing control are derived by energy shaping. The proposed method is physically motivated and avoids cancelation or domination of nonlinearities.

  12. Effect of solid retention time on membrane fouling in membrane bioreactor: from the perspective of quorum sensing and quorum quenching.

    Science.gov (United States)

    Yu, Huarong; Xu, Guoren; Qu, Fangshu; Li, Guibai; Liang, Heng

    2016-09-01

    Solid retention time (SRT) is one of the most important operational parameters in membrane bioreactor (MBR), which significantly influences membrane fouling. It is widely recognized that SRT mainly changes biomass characteristics, and then, influences membrane fouling. Effect of SRT on quorum sensing (QS) in MBR, which could also influence fouling by coordinating biofilm formation, has not been reported. In this study, fouling, QS, soluble microbial products (SMP), and extracellular polymer substances (EPS) in MBRs operated under SRTs of 4, 10, and 40 days were investigated. The results showed that as SRT increased, the abundance of quorum quenching (QQ) bacteria increased, the quorum signal degradation activity of activated sludge increased, the concentrations of signal molecules in MBR decreased, the excretion of SMP and EPS decreased, and thus membrane biofouling was alleviated. Therefore, besides altering the biomass physiochemical properties, SRT also changed the balance between QS and QQ in MBR, and in this way, influenced membrane biofouling.

  13. Water Membrane Evaporator

    Science.gov (United States)

    Ungar, Eugene K.; Almlie, Jay C.

    2010-01-01

    A water membrane evaporator (WME) has been conceived and tested as an alternative to the contamination-sensitive and corrosion-prone evaporators currently used for dissipating heat from space vehicles. The WME consists mainly of the following components: An outer stainless-steel screen that provides structural support for the components mentioned next; Inside and in contact with the stainless-steel screen, a hydrophobic membrane that is permeable to water vapor; Inside and in contact with the hydrophobic membrane, a hydrophilic membrane that transports the liquid feedwater to the inner surface of the hydrophobic membrane; Inside and in contact with the hydrophilic membrane, an annular array of tubes through which flows the spacecraft coolant carrying the heat to be dissipated; and An inner exclusion tube that limits the volume of feedwater in the WME. In operation, a pressurized feedwater reservoir is connected to the volume between the exclusion tube and the coolant tubes. Feedwater fills the volume, saturates the hydrophilic membrane, and is retained by the hydrophobic membrane. The outside of the WME is exposed to space vacuum. Heat from the spacecraft coolant is conducted through the tube walls and the water-saturated hydrophilic membrane to the liquid/vapor interface at the hydrophobic membrane, causing water to evaporate to space. Makeup water flows into the hydrophilic membrane through gaps between the coolant tubes.

  14. Dressed coordinates: The path-integral approach

    Science.gov (United States)

    Casana, R.; Flores-Hidalgo, G.; Pimentel, B. M.

    2007-02-01

    The recently introduced dressed coordinates are studied in the path-integral approach. These coordinates are defined in the context of a harmonic oscillator linearly coupled to massless scalar field and it is shown that in this model the dressed coordinates appear as a coordinate transformation preserving the path-integral functional measure. The analysis also generalizes the sum rules established in a previous work.

  15. Noncommuting Coordinates in the Landau Problem

    OpenAIRE

    Magro, Gabrielle

    2003-01-01

    Basic ideas about noncommuting coordinates are summarized, and then coordinate noncommutativity, as it arises in the Landau problem, is investigated. I review a quantum solution to the Landau problem, and evaluate the coordinate commutator in a truncated state space of Landau levels. Restriction to the lowest Landau level reproduces the well known commutator of planar coordinates. Inclusion of a finite number of Landau levels yields a matrix generalization.

  16. Permeability of Hollow Microspherical Membranes to Helium

    Science.gov (United States)

    Zinoviev, V. N.; Kazanin, I. V.; Pak, A. Yu.; Vereshchagin, A. S.; Lebiga, V. A.; Fomin, V. M.

    2016-01-01

    This work is devoted to the study of the sorption characteristics of various hollow microspherical membranes to reveal particles most suitable for application in the membrane-sorption technologies of helium extraction from a natural gas. The permeability of the investigated sorbents to helium and their impermeability to air and methane are shown experimentally. The sorption-desorption dependences of the studied sorbents have been obtained, from which the parameters of their specific permeability to helium are calculated. It has been established that the physicochemical modification of the original particles exerts a great influence on the coefficient of the permeability of a sorbent to helium. Specially treated cenospheres have displayed high efficiency as membranes for selective extraction of helium.

  17. Microcompartments within the yeast plasma membrane.

    Science.gov (United States)

    Merzendorfer, Hans; Heinisch, Jürgen J

    2013-02-01

    Recent research in cell biology makes it increasingly clear that the classical concept of compartmentation of eukaryotic cells into different organelles performing distinct functions has to be extended by microcompartmentation, i.e., the dynamic interaction of proteins, sugars, and lipids at a suborganellar level, which contributes significantly to a proper physiology. As different membrane compartments (MCs) have been described in the yeast plasma membrane, such as those defined by Can1 and Pma1 (MCCs and MCPs), Saccharomyces cerevisiae can serve as a model organism, which is amenable to genetic, biochemical, and microscopic studies. In this review, we compare the specialized microcompartment of the yeast bud neck with other plasma membrane substructures, focusing on eisosomes, cell wall integrity-sensing units, and chitin-synthesizing complexes. Together, they ensure a proper cell division at the end of mitosis, an intricately regulated process, which is essential for the survival and proliferation not only of fungal, but of all eukaryotic cells.

  18. Biomimetic membranes for sensor and separation applications

    DEFF Research Database (Denmark)

    Helix Nielsen, Claus

    2009-01-01

    massive transport of matter in and out the cell. Nature has elegantly met this challenge by developing membranes in the form of lipid bilayers in which specialized and highly efficient transport proteins are incorporated. This raises the question: is it possible to mimic biological membranes and create...... membrane-based sensor and/or separation devices? In the development of biomimetic sensor/separation technology, both channels (ion and water channels) and carriers (transporters) are important. Generally, each class of transport proteins conducts specific molecular species in and out of the cell while...... generally have a lower turnover but are capable of transport against gradients. For both classes of proteins, their unique flux-properties make them interesting as candidates in biomimetic sensor/separation devices. An ideal sensor/separation device requires the supporting biomimetic matrix to be virtually...

  19. Extracellular heme uptake and the challenges of bacterial cell membranes.

    Science.gov (United States)

    Smith, Aaron D; Wilks, Angela

    2012-01-01

    In bacteria, the fine balance of maintaining adequate iron levels while preventing the deleterious effects of excess iron has led to the evolution of sophisticated cellular mechanisms to obtain, store, and regulate iron. Iron uptake provides a significant challenge given its limited bioavailability and need to be transported across the bacterial cell wall and membranes. Pathogenic bacteria have circumvented the iron-availability issue by utilizing the hosts' heme-containing proteins as a source of iron. Once internalized, iron is liberated from the porphyrin enzymatically for cellular processes within the bacterial cell. Heme, a lipophilic and toxic molecule, poses a significant challenge in terms of transport given its chemical reactivity. As such, pathogenic bacteria have evolved sophisticated membrane transporters to coordinate, sequester, and transport heme. Recent advances in the biochemical and structural characterization of the membrane-bound heme transport proteins are discussed in the context of ligand coordination, protein-protein interaction, and heme transfer.

  20. Sandwich-structured hollow fiber membranes for osmotic power generation

    KAUST Repository

    Fu, Feng Jiang

    2015-11-01

    In this work, a novel sandwich-structured hollow fiber membrane has been developed via a specially designed spinneret and optimized spinning conditions. With this specially designed spinneret, the outer layer, which is the most crucial part of the sandwich-structured membrane, is maintained the same as the traditional dual-layer membrane. The inner substrate layer is separated into two layers: (1) an ultra-thin middle layer comprising a high molecular weight polyvinylpyrrolidone (PVP) additive to enhance integration with the outer polybenzimidazole (PBI) selective layer, and (2) an inner-layer to provide strong mechanical strength for the membrane. Experimental results show that a high water permeability and good mechanical strength could be achieved without the expensive post treatment process to remove PVP which was necessary for the dual-layer pressure retarded osmosis (PRO) membranes. By optimizing the composition, the membrane shows a maximum power density of 6.23W/m2 at a hydraulic pressure of 22.0bar when 1M NaCl and 10mM NaCl are used as the draw and feed solutions, respectively. To our best knowledge, this is the best phase inversion hollow fiber membrane with an outer selective PBI layer for osmotic power generation. In addition, this is the first work that shows how to fabricate sandwich-structured hollow fiber membranes for various applications. © 2015 Elsevier B.V.

  1. A role for the membrane in regulating Chlamydomonas flagellar length.

    Directory of Open Access Journals (Sweden)

    William Dentler

    Full Text Available Flagellar assembly requires coordination between the assembly of axonemal proteins and the assembly of the flagellar membrane and membrane proteins. Fully grown steady-state Chlamydomonas flagella release flagellar vesicles from their tips and failure to resupply membrane should affect flagellar length. To study vesicle release, plasma and flagellar membrane surface proteins were vectorially pulse-labeled and flagella and vesicles were analyzed for biotinylated proteins. Based on the quantity of biotinylated proteins in purified vesicles, steady-state flagella appeared to shed a minimum of 16% of their surface membrane per hour, equivalent to a complete flagellar membrane being released every 6 hrs or less. Brefeldin-A destroyed Chlamydomonas Golgi, inhibited the secretory pathway, inhibited flagellar regeneration, and induced full-length flagella to disassemble within 6 hrs, consistent with flagellar disassembly being induced by a failure to resupply membrane. In contrast to membrane lipids, a pool of biotinylatable membrane proteins was identified that was sufficient to resupply flagella as they released vesicles for 6 hrs in the absence of protein synthesis and to support one and nearly two regenerations of flagella following amputation. These studies reveal the importance of the secretory pathway to assemble and maintain full-length flagella.

  2. 7 CFR 23.3 - Coordination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Coordination. 23.3 Section 23.3 Agriculture Office of the Secretary of Agriculture STATE AND REGIONAL ANNUAL PLANS OF WORK State Program § 23.3 Coordination... designate an official who will be responsible for the overall coordination of the authorized programs...

  3. 47 CFR 74.638 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... frequency coordinated under this paragraph, the interference protection criteria in 47 CFR 101.105(a), (b), and (c) and the frequency usage coordination procedures in 47 CFR 101.103(d) will apply. (c) For each... 47 Telecommunication 4 2010-10-01 2010-10-01 false Frequency coordination. 74.638 Section...

  4. 47 CFR 87.305 - Frequency coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Frequency coordination. 87.305 Section 87.305... Flight Test Stations § 87.305 Frequency coordination. (a)(1) Each application for a new station license... prior coordinations and assignments on the proposed frequency(ies). The committee must also...

  5. 47 CFR 27.57 - International coordination.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false International coordination. 27.57 Section 27.57... COMMUNICATIONS SERVICES Technical Standards § 27.57 International coordination. (a) WCS operations in the border areas shall be subject to coordination with those countries and provide protection to non-U.S...

  6. 42 CFR 38.1 - Purpose; coordination.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Purpose; coordination. 38.1 Section 38.1 Public... DISASTER ASSISTANCE FOR CRISIS COUNSELING AND TRAINING § 38.1 Purpose; coordination. (a) Purpose. This part... providing those professional counseling services. (b) Coordination. The Secretary, acting through the...

  7. 45 CFR 98.82 - Coordination.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Coordination. 98.82 Section 98.82 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CHILD CARE AND DEVELOPMENT FUND Indian Tribes § 98.82 Coordination. Tribal applicants shall coordinate as required by §§ 98.12 and 98.14 and: (a) To...

  8. Construction and minimality of coordinated linear systems

    NARCIS (Netherlands)

    Kempker, P.L.; Ran, A.C.M.; Schuppen, J.H. van

    2014-01-01

    Coordinated linear systems are a particular class of hierarchical systems with a top-to-bottom information structure, consisting of a coordinator system and two or more subsystems. This paper deals with the construction and minimality of coordinated linear systems. Construction procedures are given

  9. 36 CFR 13.1104 - Coordinates.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Coordinates. 13.1104 Section 13.1104 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR... Administrative Provisions § 13.1104 Coordinates. All coordinates referenced in this subpart use horizontal...

  10. 33 CFR 166.103 - Geographic coordinates.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Geographic coordinates. 166.103...) PORTS AND WATERWAYS SAFETY SHIPPING SAFETY FAIRWAYS General § 166.103 Geographic coordinates. Geographic coordinates expressed in terms of latitude or longitude, or both, are not intended for plotting on maps...

  11. 33 CFR 167.3 - Geographic coordinates.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Geographic coordinates. 167.3...) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES General § 167.3 Geographic coordinates. Geographic coordinates are defined using North American 1927 Datum (NAD 27) unless indicated otherwise....

  12. Managing interteam coordination within and between organizations

    NARCIS (Netherlands)

    de Vries, Thomas Arend

    2015-01-01

    To accomplish complex tasks and effectively respond to environmental contingencies, teams must coordinate task-related issues with other teams (i.e., interteam coordination). Regrettably, interteam coordination is often complicated by misunderstandings that can arise from differences in teams’ langu

  13. 78 FR 34035 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-06-06

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Forest Resource Coordinating Committee will meet via teleconference every month on... conference call will be posted to the Forest Resource Coordinating Committee Web site, http://www.fs.fed.us...

  14. 78 FR 57128 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-09-17

    ... Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Forest Resource Coordinating Committee Meeting will meet in Rosslyn, Virginia. The... inspect comments received on the Forest Resource Coordinating Committee Web site at http://www.fs.fed.us...

  15. 78 FR 44519 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-07-24

    ... Office of the Secretary Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice; Re-establishment of the Forest Resource Coordinating Committee and call for nominations. SUMMARY: The Department of Agriculture re-established the Forest Resource Coordinating Committee (Committee...

  16. Is fiscal policy coordination in EMU desirable?

    NARCIS (Netherlands)

    R.M.W.J. Beetsma; X. Debrun; F.J.G.M. Klaassen

    2001-01-01

    'It is widely argued that Europe's unified monetary policy calls for international coordination of fiscal policy. This paper surveys the issues involved with the coordination of fiscal policies as a demand management tool. We discuss ex-ante and ex-post coordination. The former operates through bind

  17. 49 CFR 214.325 - Train coordination.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Train coordination. 214.325 Section 214.325..., DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.325 Train coordination. Working limits established by a roadway worker through the use of train coordination shall comply with the...

  18. Coordination in serial-parallel image processing

    Science.gov (United States)

    Wójcik, Waldemar; Dubovoi, Vladymyr M.; Duda, Marina E.; Romaniuk, Ryszard S.; Yesmakhanova, Laura; Kozbakova, Ainur

    2015-12-01

    Serial-parallel systems used to convert the image. The control of their work results with the need to solve coordination problem. The paper summarizes the model of coordination of resource allocation in relation to the task of synchronizing parallel processes; the genetic algorithm of coordination developed, its adequacy verified in relation to the process of parallel image processing.

  19. 77 FR 778 - Council Coordination Committee Meeting

    Science.gov (United States)

    2012-01-06

    ... National Oceanic and Atmospheric Administration RIN 0648-XA918 Council Coordination Committee Meeting...), Commerce. ACTION: Notice of a public meeting. SUMMARY: NMFS will host a meeting of the Council Coordination... Reauthorization Act (MSRA) of 2006 established the Council Coordination Committee by amending Section 302 (16...

  20. Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation

    OpenAIRE

    Haremaki, Tomomi; Fraser, Stuart T.; Kuo, Yien-Ming; Baron, Margaret H.; Weinstein, Daniel C.

    2007-01-01

    Embryogenesis involves two distinct processes. On the one hand, cells must specialize, acquiring fates appropriate to their positions (differentiation); on the other hand, they must physically construct the embryo through coordinated mechanical activity (morphogenesis). In early vertebrate development, fibroblast growth factor (FGF) regulates multiple embryonic events, including germ layer differentiation and morphogenesis; the cellular components that direct FGF signaling to evoke these diff...

  1. 38 CFR 17.242 - Coordination of programs with Department of Health and Human Services.

    Science.gov (United States)

    2010-07-01

    ... specialized medical resources or medical information services shall be coordinated to a maximum extent... jurisdiction of the Department of Health and Human Services. Grants for Exchange of Information ... with Department of Health and Human Services. 17.242 Section 17.242 Pensions, Bonuses, and...

  2. Geometrical Reconstruction and CNC Process of Spurious Tympanic Membrane Based on Reverse Engineering

    Institute of Scientific and Technical Information of China (English)

    LU Hong; PENG Jun; ZHOU Yongqing

    2006-01-01

    Perforation of tympanic membrane is one of the main reasons for both deafness and dyssaudia. We could improve and restore audition by restoring or replacing the tympanic membrane. So, whether you can make the spurious tympanic membrane successfully is one of the keys to a successful operation. Utilizing CMM (Coordinate Measuring Machine) measurement equipment, we measured tympanic membrane model precisely and digitally. We also analysed the measured data by point to surface and we have successfully reconstructed the CAD model of the spurious tympanic membrane. Using the model we have got, we schemed out the mold of spurious tympanic membrane. In addition, we utilized MasterCAM compiling CNC (Computerized Numerical Control) code and simulating the course of working. Ultimately, we obtained the mold of spurious tympanic membrane. Our research in this article has great significance to the success of spurious tympanic membrane grafting operation.

  3. Supported ionic liquid membrane in membrane reactor

    Science.gov (United States)

    Makertihartha, I. G. B. N.; Zunita, M.; Dharmawijaya, P. T.; Wenten, I. G.

    2017-01-01

    Membrane reactor is a device that integrates membrane based separation and (catalytic) chemical reaction vessel in a single device. Ionic liquids, considered to be a relatively recent magical chemical due to their unique properties, have a large variety of applications in all areas of chemical industries. Moreover, the ionic liquid can be used as membrane separation layer and/or catalytically active site. This paper will review utilization of ionic liquid in membrane reactor related applications especially Fischer-Tropsch, hydrogenation, and dehydrogenation reaction. This paper also reviews about the capability of ionic liquid in equilibrium reaction that produces CO2 product so that the reaction will move towards the product. Water gas shift reaction in ammonia production also direct Dimethyl Ether (DME) synthesis that produces CO2 product will be discussed. Based on a review of numerous articles on supported ionic liquid membrane (SILM) indicate that ionic liquids have the potential to support the process of chemical reaction and separation in a membrane reactor.

  4. Application of dynamic membranes in anaerobic membranes in anaerobic membrane bioreactor systems

    NARCIS (Netherlands)

    Erşahin, M.E.

    2015-01-01

    Anaerobic membrane bioreactors (AnMBRs) physically ensure biomass retention by the application of a membrane filtration process. With growing application experiences from aerobic membrane bioreactors (MBRs), the combination of membrane and anaerobic processes has received much attention and become

  5. Coordination Chemistry of Microbial Iron Transport.

    Science.gov (United States)

    Raymond, Kenneth N; Allred, Benjamin E; Sia, Allyson K

    2015-09-15

    This Account focuses on the coordination chemistry of the microbial iron chelators called siderophores. The initial research (early 1970s) focused on simple analogs of siderophores, which included hydroxamate, catecholate, or hydroxycarboxylate ligands. The subsequent work increasingly focused on the transport of siderophores and their microbial iron transport. Since these are pseudo-octahedral complexes often composed of bidentate ligands, there is chirality at the metal center that in principle is independent of the ligand chirality. It has been shown in many cases that chiral recognition of the complex occurs. Many techniques have been used to elucidate the iron uptake processes in both Gram-positive (single membrane) and Gram-negative (double membrane) bacteria. These have included the use of radioactive labels (of ligand, metal, or both), kinetically inert metal complexes, and Mössbauer spectroscopy. In general, siderophore recognition and transport involves receptors that recognize the metal chelate portion of the iron-siderophore complex. A second, to date less commonly found, mechanism called the siderophore shuttle involves the receptor binding an apo-siderophore. Since one of the primary ways that microbes compete with each other for iron stores is the strength of their competing siderophore complexes, it became important early on to characterize the solution thermodynamics of these species. Since the acidity of siderophores varies significantly, just the stability constant does not give a direct measure of the relative competitive strength of binding. For this reason, the pM value is compared. The pM, like pH, is a measure of the negative log of the free metal ion concentration, typically calculated at pH 7.4, and standard total concentrations of metal and ligand. The characterization of the electronic structure of ferric siderophores has done much to help explain the high stability of these complexes. A new chapter in siderophore science has emerged

  6. Coordinated hybrid automatic repeat request

    KAUST Repository

    Makki, Behrooz

    2014-11-01

    We develop a coordinated hybrid automatic repeat request (HARQ) approach. With the proposed scheme, if a user message is correctly decoded in the first HARQ rounds, its spectrum is allocated to other users, to improve the network outage probability and the users\\' fairness. The results, which are obtained for single- and multiple-antenna setups, demonstrate the efficiency of the proposed approach in different conditions. For instance, with a maximum of M retransmissions and single transmit/receive antennas, the diversity gain of a user increases from M to (J+1)(M-1)+1 where J is the number of users helping that user.

  7. Application coordination in pervasive systems

    CERN Document Server

    Majuntke, Verena Elisabeth

    2013-01-01

    Pervasive applications are designed to support users in their daily life. For this purpose, applications interact with their environment, i.e. their context. They are able to adapt themselves to context changes or to explicitly change the context via actuators. If multiple applications are executed in the same context, interferences are likely to occur. To manage interferences, a coordination framework is presented in this thesis. Interferences are detected using a context model and information about applications' interaction with the context. The resolution of interference is achieved through

  8. Geometrical product specifications. Datums and coordinate systems

    Science.gov (United States)

    Glukhov, V. I.; Ivleva, I. A.; Zlatkina, O. Y.

    2017-06-01

    The work is devoted to the relevant topic such as the technical products quality improvement due to the geometrical specifications accuracy. The research purpose is to ensure the quality indicators on the basis of the systematic approach to the values normalization and geometrical specifications accuracy in the workpiece coordinate systems in the process of design. To achieve the goal two tasks are completed such as the datum features classification according to the number of linear and angular freedom degrees constraints, called the datums informativeness, and the rectangular coordinate systems identification, materialized by workpiece datums sets. The datum features informativeness characterizes the datums functional purpose to limit product workpiece linear and angular degrees of freedom. The datum features informativeness numerically coincides with the kinematic pairs classes and couplings in mechanics. The datum features informativeness identifies the coordinate system without the location redundancy. Each coordinate plane of a rectangular coordinate system has different informativeness 3 + 2 + 1. Each coordinate axis also has different informativeness 4+2+Θ (zero). It is possible to establish the associated workpiece position with three linear and three angular coordinates relative to two axes with the informativeness 4 and 2. is higher, the more informativeness of the coordinate axis or a coordinate plane is, the higher is the linear and angular coordinates accuracy, the coordinate being plotted along the coordinate axis or plane. The systematic approach to the geometrical products specifications positioning in coordinate systems is the scientific basis for a natural transition to the functional dimensions of features position - coordinating dimensions and the size of the features form - feature dimensions of two measures: linear and angular ones. The products technical quality improving is possible due to the coordinate systems introduction materialized by

  9. Axon-glia interaction and membrane traffic in myelin formation

    OpenAIRE

    2014-01-01

    In vertebrate nervous systems myelination of neuronal axons has evolved to increase conduction velocity of electrical impulses with minimal space and energy requirements. Myelin is formed by specialized glial cells which ensheath axons with a lipid-rich insulating membrane. Myelination is a multi-step process initiated by axon-glia recognition triggering glial polarization followed by targeted myelin membrane expansion and compaction. Thereby, a myelin sheath of complex subdomain structure is...

  10. Lipids and Membrane Microdomains in HIV-1 Replication

    OpenAIRE

    Waheed, Abdul A.; Freed, Eric O.

    2009-01-01

    Several critical steps in the replication cycle of human immunodeficiency virus type 1 (HIV-1) – entry, assembly and budding – are complex processes that take place at the plasma membrane of the host cell. A growing body of data indicates that these early and late steps in HIV-1 replication take place in specialized plasma membrane microdomains, and that many of the viral and cellular components required for entry, assembly, and budding are concentrated in these microdomains. In particular, a...

  11. The gene vitellogenin has multiple coordinating effects on social organization.

    Directory of Open Access Journals (Sweden)

    C Mindy Nelson

    2007-03-01

    Full Text Available Temporal division of labor and foraging specialization are key characteristics of honeybee social organization. Worker honeybees (Apis mellifera initiate foraging for food around their third week of life and often specialize in collecting pollen or nectar before they die. Variation in these fundamental social traits correlates with variation in worker reproductive physiology. However, the genetic and hormonal mechanisms that mediate the control of social organization are not understood and remain a central question in social insect biology. Here we demonstrate that a yolk precursor gene, vitellogenin, affects a complex suite of social traits. Vitellogenin is a major reproductive protein in insects in general and a proposed endocrine factor in honeybees. We show by use of RNA interference (RNAi that vitellogenin gene activity paces onset of foraging behavior, primes bees for specialized foraging tasks, and influences worker longevity. These findings support the view that the worker specializations that characterize hymenopteran sociality evolved through co-option of reproductive regulatory pathways. Further, they demonstrate for the first time how coordinated control of multiple social life-history traits can originate via the pleiotropic effects of a single gene that affects multiple physiological processes.

  12. Emulsification using microporous membranes

    Directory of Open Access Journals (Sweden)

    Goran T. Vladisavljević

    2011-10-01

    Full Text Available Membrane emulsification is a process of injecting a pure dispersed phase or pre-emulsion through a microporous membrane into the continuous phase. As a result of the immiscibility of the two phases, droplets of the dispersed phase are formed at the outlets of membrane pores. The droplets formed in the process are removed from the membrane surface by applying cross-flow or stirring of the continuous phase or using a dynamic (rotating or vibrating membrane. The most commonly used membrane for emulsification is the Shirasu Porous Glass (SPG membrane, fabricated through spinodal decomposition in a melt consisting of Japanese volcanic ash (Shirasu, boric acid and calcium carbonate. Microsieve membranes are increasingly popular as an alternative to highly tortuous glass and ceramic membranes. Microsieves are usually fabricated from nickel by photolithography and electroplating or they can be manufactured from silicon nitride via Reactive Ion Etching (RIE. An advantage of microsieves compared to the SPG membrane is in much higher transmembrane fluxes and higher tolerance to fouling by the emulsion ingredients due to the existence of short, straight through pores. Unlike conventional emulsification devices such as high-pressure valve homogenisers and rotor-stator devices, membrane emulsification devices permit a precise control over the mean pore size over a wide range and during the process insignificant amount of energy is dissipated as heat. The drop size is primarily determined by the pore size, but it depends also on other parameters, such as membrane wettability, emulsion formulation, shear stress on the membrane surface, transmembrane pressure, etc.

  13. Harmonic Vibrational Analysis in Delocalized Internal Coordinates.

    Science.gov (United States)

    Jensen, Frank; Palmer, David S

    2011-01-11

    It is shown that a principal component analysis of a large set of internal coordinates can be used to define a nonredundant set of delocalized internal coordinates suitable for the calculation of harmonic vibrational normal modes. The selection of internal coordinates and the principal component analysis provide large degrees of freedom in extracting a nonredundant set of coordinates, and thus influence how the vibrational normal modes are described. It is shown that long-range coordinates may be especially suitable for describing low-frequency global deformation modes in proteins.

  14. Unpacking Coordination Benefits in Supply Networks

    DEFF Research Database (Denmark)

    Petrick, Irene J.; Maitland, Carleen; Pogrebnyakov, Nicolai

    2016-01-01

    This paper examines how coordination among firms in supply networks generates benefits in the short and long terms for firms. It focuses on information technology (IT) and process improvement coordination. Analysis was performed on quantitative and qualitative data from a sample of SMEs in plastics...... manufacturing in Pennsylvania. Results indicate that coordination on both IT and process improvement leads to short- and long-term benefits. These relationships were mediated by the adoption of innovations (when coordinating on IT) and access to new capabilities (in process improvement coordination......). These results extend the understanding of how participation in supply networks benefits individual firms....

  15. International SOF Coordination Center (ISCC)

    Science.gov (United States)

    2014-06-01

    Theory, and Policy Topic 2: Organizational Concepts and Approaches Topic 4: Experimentation, Metrics, and Analysis Mr. Ken D. Teske Mr...Point of Contact Ken D. Teske United States Special Operations Command 7701 Tampa Point Boulevard MacDill Air Force Base, Florida 33621 (757) 510...ISCC) Mr. Ken D. Teske Mr. Michael D. Tisdel Mr. William C. Fleser 19th ICCRTS 17 June 2014 Paper ID 004 Agenda • The Concept • The OV-1 View

  16. Ytterbium Coordination Polymer with Four Different Coordination Numbers: The First Structural Characterization of Lanthanide Phthalate Complex

    Institute of Scientific and Technical Information of China (English)

    WAN,Yong-Hong(万永红); JIN,Lin-Pei(金林培); WANG,Ke-Zhi(王科志)

    2002-01-01

    The novel ytterbium coordination polymer is a two-dimensional framework in which the central metal ions have four different coordination numhers and form four kinds of coordination polyhedra. The four kinds of coordination polyhedra connect into infinite chains by sharing oxygen atoms

  17. Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium.

    Directory of Open Access Journals (Sweden)

    Johannes Schneider

    2015-04-01

    Full Text Available Lipid rafts are membrane microdomains specialized in the regulation of numerous cellular processes related to membrane organization, as diverse as signal transduction, protein sorting, membrane trafficking or pathogen invasion. It has been proposed that this functional diversity would require a heterogeneous population of raft domains with varying compositions. However, a mechanism for such diversification is not known. We recently discovered that bacterial membranes organize their signal transduction pathways in functional membrane microdomains (FMMs that are structurally and functionally similar to the eukaryotic lipid rafts. In this report, we took advantage of the tractability of the prokaryotic model Bacillus subtilis to provide evidence for the coexistence of two distinct families of FMMs in bacterial membranes, displaying a distinctive distribution of proteins specialized in different biological processes. One family of microdomains harbors the scaffolding flotillin protein FloA that selectively tethers proteins specialized in regulating cell envelope turnover and primary metabolism. A second population of microdomains containing the two scaffolding flotillins, FloA and FloT, arises exclusively at later stages of cell growth and specializes in adaptation of cells to stationary phase. Importantly, the diversification of membrane microdomains does not occur arbitrarily. We discovered that bacterial cells control the spatio-temporal remodeling of microdomains by restricting the activation of FloT expression to stationary phase. This regulation ensures a sequential assembly of functionally specialized membrane microdomains to strategically organize signaling networks at the right time during the lifespan of a bacterium.

  18. D Coordinate Transformation Using Artificial Neural Networks

    Science.gov (United States)

    Konakoglu, B.; Cakır, L.; Gökalp, E.

    2016-10-01

    Two coordinate systems used in Turkey, namely the ED50 (European Datum 1950) and ITRF96 (International Terrestrial Reference Frame 1996) coordinate systems. In most cases, it is necessary to conduct transformation from one coordinate system to another. The artificial neural network (ANN) is a new method for coordinate transformation. One of the biggest advantages of the ANN is that it can determine the relationship between two coordinate systems without a mathematical model. The aim of this study was to investigate the performances of three different ANN models (Feed Forward Back Propagation (FFBP), Cascade Forward Back Propagation (CFBP) and Radial Basis Function Neural Network (RBFNN)) with regard to 2D coordinate transformation. To do this, three data sets were used for the same study area, the city of Trabzon. The coordinates of data sets were measured in the ED50 and ITRF96 coordinate systems by using RTK-GPS technique. Performance of each transformation method was investigated by using the coordinate differences between the known and estimated coordinates. The results showed that the ANN algorithms can be used for 2D coordinate transformation in cases where optimum model parameters are selected.

  19. Collaborative Supply Chain Planning and Coordination

    DEFF Research Database (Denmark)

    Wong, Chee Yew

    between the toy manufacturer and three European retailers. These three case studies provide evidences that the toy manufacturer and the retailers followed some particular patterns of planning coordination processes; they also practised some patterns of coordination behaviour during the coordination...... processes, particularly the behaviour of risk-taking/avoidance, conflict resolutions, and self-interest. All these lead to conclusion of five propositions or principles of supply chain coordination, and the theory of coordination process and behaviour. Combining the propositions of responsiveness......This thesis contains main results from an industrial PhD research in the areas of supply chain strategy, planning, and coordination. It applies the concepts of responsiveness and coordination to reduce mismatch of supply and demand, especially for a volatile and seasonal supply chain. It involves...

  20. PRES 2012 special section

    DEFF Research Database (Denmark)

    Klemeš, Jiří Jaromír; Varbanov, Petar Sabev; Wang, Qiuwang;

    2013-01-01

    This Special Section provides introduction to the 15th Conference Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction (PRES 2012). In this editorial introduction, the editors are highlighting the individual articles included in this issue and discussing the m...... the main points. The main areas of this issue can be summarised as: Process Integration for Energy Saving, Integrating Renewable Energy Sources and Energy Optimisation issues.......This Special Section provides introduction to the 15th Conference Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction (PRES 2012). In this editorial introduction, the editors are highlighting the individual articles included in this issue and discussing...

  1. SPECIAL ISSUE EDITORIAL

    Institute of Scientific and Technical Information of China (English)

    Amy J.C.TRAPPEY; Fataneh Taghaboni DUTTA; Kai-Ying CHEN

    2010-01-01

    @@ This special issue of Journal of Systems Science and Systems Engineering recognizes the contributions of authors and participants in the 16th ISPE International Conference on Concurrent Engineering (CE2009), 2009 ASME International Manufacturing - Science and Engineering Conference (MSEC) and 2009 IEEE International Conference on Systems, Man and Cybernetics. Among related papers presented in these conferences, the guest editors have selectively identified and invited the authors to re-write and extend their works to full-length papers for re-submission to the special issue.

  2. Specialization, Outsourcing and Wages

    DEFF Research Database (Denmark)

    Munch, Jakob Roland; Rose Skaksen, Jan

    2005-01-01

    This paper studies the impact of outsourcing on individual wages. In contrast to the standard approach in the literature, we focus on domestic outsourcing as well as foreign outsourcing. By using a simple theoretical model, we argue that, if outsourcing is associated with specialization gains...... arising from an increase in the extent of the market for intermediate goods, domestic outsourcing tends to increase wages for both unskilled and skilled labor. We use a panel data set of workers in Danish manufacturing industries to show that domestic and foreign outsurcing affect wages as predicted...... by the theory.Keywords: Outsourcing, Comparative advantage, Specialization, Wages.JEL Classification: F16, J31, C23....

  3. Procurement with specialized firms

    DEFF Research Database (Denmark)

    Boone, Jan; Schottmüller, Christoph

    2016-01-01

    This paper analyzes optimal procurement mechanisms when firms are specialized. The procurement agency has incomplete information concerning the firms’ cost functions and values high quality as well as low price. Lower type firms are cheaper (more expensive) than higher type firms when providing low...... (high) quality. With specialized firms, distortion is limited and a mass of types earns zero profits. The optimal mechanism can be inefficient: types providing lower second best welfare win against types providing higher second best welfare. As standard scoring rule auctions cannot always implement...

  4. Superficial Dermal Fibroblasts Enhance Basement Membrane and Epidermal Barrier Formation in Tissue-Engineered Skin: Implications for Treatment of Skin Basement Membrane Disorders

    OpenAIRE

    2013-01-01

    Basement membrane is a highly specialized structure that binds the dermis and the epidermis of the skin, and is mainly composed of laminins, nidogen, collagen types IV and VII, and the proteoglycans, collagen type XVIII and perlecan, all of which play critical roles in the function and resilience of skin. Both dermal fibroblasts and epidermal keratinocytes contribute to the development of the basement membrane, and in turn the basement membrane and underlying dermis influence the development ...

  5. Pb2+ as modulator of protein-membrane interactions.

    Science.gov (United States)

    Morales, Krystal A; Lasagna, Mauricio; Gribenko, Alexey V; Yoon, Youngdae; Reinhart, Gregory D; Lee, James C; Cho, Wonhwa; Li, Pingwei; Igumenova, Tatyana I

    2011-07-13

    Lead is a potent environmental toxin that mimics the effects of divalent metal ions, such as zinc and calcium, in the context of specific molecular targets and signaling processes. The molecular mechanism of lead toxicity remains poorly understood. The objective of this work was to characterize the effect of Pb(2+) on the structure and membrane-binding properties of C2α. C2α is a peripheral membrane-binding domain of Protein Kinase Cα (PKCα), which is a well-documented molecular target of lead. Using NMR and isothermal titration calorimetry (ITC) techniques, we established that C2α binds Pb(2+) with higher affinity than its natural cofactor, Ca(2+). To gain insight into the coordination geometry of protein-bound Pb(2+), we determined the crystal structures of apo and Pb(2+)-bound C2α at 1.9 and 1.5 Å resolution, respectively. A comparison of these structures revealed that the metal-binding site is not preorganized and that rotation of the oxygen-donating side chains is required for the metal coordination to occur. Remarkably, we found that holodirected and hemidirected coordination geometries for the two Pb(2+) ions coexist within a single protein molecule. Using protein-to-membrane Förster resonance energy transfer (FRET) spectroscopy, we demonstrated that Pb(2+) displaces Ca(2+) from C2α in the presence of lipid membranes through the high-affinity interaction with the membrane-unbound C2α. In addition, Pb(2+) associates with phosphatidylserine-containing membranes and thereby competes with C2α for the membrane-binding sites. This process can contribute to the inhibitory effect of Pb(2+) on the PKCα activity.

  6. Proteins causing membrane fouling in membrane bioreactors.

    Science.gov (United States)

    Miyoshi, Taro; Nagai, Yuhei; Aizawa, Tomoyasu; Kimura, Katsuki; Watanabe, Yoshimasa

    2015-01-01

    In this study, the details of proteins causing membrane fouling in membrane bioreactors (MBRs) treating real municipal wastewater were investigated. Two separate pilot-scale MBRs were continuously operated under significantly different operating conditions; one MBR was a submerged type whereas the other was a side-stream type. The submerged and side-stream MBRs were operated for 20 and 10 days, respectively. At the end of continuous operation, the foulants were extracted from the fouled membranes. The proteins contained in the extracted foulants were enriched by using the combination of crude concentration with an ultrafiltration membrane and trichloroacetic acid precipitation, and then separated by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). The N-terminal amino acid sequencing analysis of the proteins which formed intensive spots on the 2D-PAGE gels allowed us to partially identify one protein (OmpA family protein originated from genus Brevundimonas or Riemerella anatipestifer) from the foulant obtained from the submerged MBR, and two proteins (OprD and OprF originated from genus Pseudomonas) from that obtained from the side-stream MBR. Despite the significant difference in operating conditions of the two MBRs, all proteins identified in this study belong to β-barrel protein. These findings strongly suggest the importance of β-barrel proteins in developing membrane fouling in MBRs.

  7. Chelating polymeric membranes

    KAUST Repository

    Peinemann, Klaus-Viktor

    2015-01-22

    The present application offers a solution to the current problems associated with recovery and recycling of precious metals from scrap material, discard articles, and other items comprising one or more precious metals. The solution is premised on a microporous chelating polymeric membrane. Embodiments include, but are not limited to, microporous chelating polymeric membranes, device comprising the membranes, and methods of using and making the same.

  8. Polyarylether composition and membrane

    Science.gov (United States)

    Hung, Joyce; Brunelle, Daniel Joseph; Harmon, Marianne Elisabeth; Moore, David Roger; Stone, Joshua James; Zhou, Hongyi; Suriano, Joseph Anthony

    2010-11-09

    A composition including a polyarylether copolymer is provided. The copolymer includes a polyarylether backbone; and a sulfonated oligomeric group bonded to the polyarylether suitable for use as a cation conducting membrane. Method of bonding a sulfonated oligomeric group to the polyarylether backbone to form a polyarylether copolymer. The membrane may be formed from the polyarylether copolymer composition. The chain length of the sulfonated oligomeric group may be controlled to affect or control the ion conductivity of the membrane.

  9. Membrane binding domains

    OpenAIRE

    Hurley, James H.

    2006-01-01

    Eukaryotic signaling and trafficking proteins are rich in modular domains that bind cell membranes. These binding events are tightly regulated in space and time. The structural, biochemical, and biophysical mechanisms for targeting have been worked out for many families of membrane binding domains. This review takes a comparative view of seven major classes of membrane binding domains, the C1, C2, PH, FYVE, PX, ENTH, and BAR domains. These domains use a combination of specific headgroup inter...

  10. Applications of membrane computing

    CERN Document Server

    Ciobanu, Gabriel; Păun, Gheorghe

    2006-01-01

    Membrane computing is a branch of natural computing which investigates computing models abstracted from the structure and functioning of living cells and from their interactions in tissues or higher-order biological structures. The models considered, called membrane systems (P systems), are parallel, distributed computing models, processing multisets of symbols in cell-like compartmental architectures. In many applications membrane systems have considerable advantages - among these are their inherently discrete nature, parallelism, transparency, scalability and nondeterminism. In dedicated cha

  11. Relationships between physical activity, physical fitness, somatic fitness, and coordination along childhood and adolescence

    Directory of Open Access Journals (Sweden)

    João Paulo Saraiva

    2010-12-01

    Full Text Available The two main goals of this review were to understand how the relationships between physical activity, physical fitness, somatic fitness, and coordination are established along the motor development of children and adolescents, and how they would influence their future lives. The web based bibliographic database B-On was searched for peer-reviewed publications during the last decade (2000 to 2009. Search criteria included all articles on relationships between any two of the above named factors. Although different methodological designs and variables were found as markers for the same factor, overall results suggested the existence of a clear positive relationship among physical activity, physical fitness, somatic fitness, and coordination from childhood to adolescence, with a special relevance for the relationship between physical activity and coordination. It was also noted a renewed interest on physical activity and motor coordination developmental characteristics and relationships as well as on their lifelong health effects.

  12. Finite time coordinated formation control for spacecraft formation flying under directed communication topology

    Science.gov (United States)

    Ran, Dechao; Chen, Xiaoqian; Misra, Arun K.

    2017-07-01

    This paper investigates the finite time coordinated formation control problem for spacecraft formation flying (SFF) under the assumption of directed communication topology. By using the neighborhood state measurements, a robust finite time coordinated formation controller is firstly designed based on the nonsingular terminal sliding mode surface. To address the special case that the desired trajectory of the formation is only accessible to a subset of spacecraft in the formation, an adaptive finite time coordinated formation controller is also proposed by designing a novel sliding mode surface. In both cases, the external disturbances are explicitly taken into account. Rigorous theoretical analysis proves that the proposed control schemes ensure that the closed-loop system can track the desired time-varying trajectory in finite time. Numerical simulations are presented that not only highlights the closed-loop performance benefits from the proposed control algorithms, but also illustrates the effectiveness in the presence of external disturbances when compared with the existing coordinated formation control schemes.

  13. Gas separation membranes

    Science.gov (United States)

    Schell, William J.

    1979-01-01

    A dry, fabric supported, polymeric gas separation membrane, such as cellulose acetate, is prepared by casting a solution of the polymer onto a shrinkable fabric preferably formed of synthetic polymers such as polyester or polyamide filaments before washing, stretching or calendering (so called griege goods). The supported membrane is then subjected to gelling, annealing, and drying by solvent exchange. During the processing steps, both the fabric support and the membrane shrink a preselected, controlled amount which prevents curling, wrinkling or cracking of the membrane in flat form or when spirally wound into a gas separation element.

  14. Anion exchange membrane

    Science.gov (United States)

    Verkade, John G; Wadhwa, Kuldeep; Kong, Xueqian; Schmidt-Rohr, Klaus

    2013-05-07

    An anion exchange membrane and fuel cell incorporating the anion exchange membrane are detailed in which proazaphosphatrane and azaphosphatrane cations are covalently bonded to a sulfonated fluoropolymer support along with anionic counterions. A positive charge is dispersed in the aforementioned cations which are buried in the support to reduce the cation-anion interactions and increase the mobility of hydroxide ions, for example, across the membrane. The anion exchange membrane has the ability to operate at high temperatures and in highly alkaline environments with high conductivity and low resistance.

  15. Photoresponsive nanostructured membranes

    KAUST Repository

    Madhavan, P.

    2016-07-26

    The perspective of adding stimuli-response to isoporous membranes stimulates the development of separation devices with pores, which would open or close under control of environment chemical composition, temperature or exposure to light. Changes in pH and temperature have been previously investigated. In this work, we demonstrate for the first time the preparation of photoresponsive isoporous membranes, applying self-assembly non-solvent induced phase separation to a new light responsive block copolymer. First, we optimized the membrane formation by using poly(styrene-b-anthracene methyl methacrylate-b-methylmethacrylate) (PS-b-PAnMMA-b-PMMA) copolymer, identifying the most suitable solvent, copolymer block length, and other parameters. The obtained final triblock copolymer membrane morphologies were characterized using atomic force and electron microscopy. The microscopic analysis reveals that the PS-b-PAnMMA-b-PMMA copolymer can form both lamellar and ordered hexagonal nanoporous structures on the membrane top layer in appropriate solvent compositions. The nanostructured membrane emits fluorescence due to the presence of the anthracene mid-block. On irradiation of light the PS-b-PAnMMA-b-PMMA copolymer membranes has an additional stimuli response. The anthracene group undergoes conformational changes by forming [4 + 4] cycloadducts and this alters the membrane\\'s water flux and solute retention. © 2016 The Royal Society of Chemistry.

  16. Special Needs: A Philosophical Analysis

    Science.gov (United States)

    Vehmas, Simo

    2010-01-01

    This paper attempts to illuminate a central concept and idea in special education discourse, namely, "special needs". It analyses philosophically what needs are and on what grounds they are defined as "special" or "exceptional". It also discusses whether sorting needs into ordinary and special is discriminatory. It is argued that individualistic…

  17. Subdiffusion in a system with thin membranes.

    Science.gov (United States)

    Kosztołowicz, Tadeusz; Dworecki, Kazimierz; Lewandowska, Katarzyna D

    2012-08-01

    We study both theoretically and experimentally a process of subdiffusion in a system with two thin membranes. The theoretical model uses Green's functions obtained for the membrane system by means of the generalized method of images. These Green's functions are combinations of the fundamental solutions to a fractional subdiffusion equation describing subdiffusion in a homogenous, unbounded system. Using Green's functions we find analytical formulas describing the time evolution of concentration profiles and the time evolution of the amount of substance that remains in the region between the membranes. The concentration profiles fulfill a new boundary condition at the membrane, in which the membrane permeability is assumed to change over time according to the special formula presented in the paper. These concentration profiles fulfill a standard subdiffusion equation with fractional Riemann-Liouville time derivative only approximately, but they coincide very well with the experimental data. Fitting the theoretical functions in with the experimental results, we also estimate the subdiffusion coefficient of polyethylene glycol 2000 in agarose hydrogel.

  18. Track etching technique in membrane technology

    Energy Technology Data Exchange (ETDEWEB)

    Apel, P. E-mail: apel@lnr.jinr.ru

    2001-06-01

    Track membrane (TM) technology is an example of industrial application of track etching technique. Track-etch membranes offer distinct advantages over conventional membranes due to their precisely determined structure. Their pore size, shape and density can be varied in a controllable manner so that a membrane with the required transport and retention characteristics can be produced. The use of heavy ion accelerators made it possible to vary LET of track-forming particles, angle distribution of pore channels and pore lengths. So far the track formation and etching process has been studied in much detail for several polymeric materials. Today we understand determining factors and have numerous empirical data enabling us to manufacture any particular product based on polyethylene terephthalate (PET) or polycarbonate (PC) films. Pore shape can be made cylindrical, conical, funnel-like, or cigar-like at will. A number of modification methods has been developed for creating TMs with special properties and functions. Applications of 'conventional' track membranes can be categorized into three groups: process filtration, cell culture, and laboratory filtration. The use in biology stands out among other areas. Nuclear track pores find diverse applications as model systems and as templates for the synthesis of micro- and nanostructures.

  19. Creating Special Events

    Science.gov (United States)

    deLisle, Lee

    2009-01-01

    "Creating Special Events" is organized as a systematic approach to festivals and events for students who seek a career in event management. This book looks at the evolution and history of festivals and events and proceeds to the nuts and bolts of event management. The book presents event management as the means of planning, organizing, directing,…

  20. Special Milk Program

    Science.gov (United States)

    US Department of Agriculture, 2009

    2009-01-01

    The Special Milk Program provides milk to children in schools, child care institutions and eligible camps that do not participate in other Federal child nutrition meal service programs. The program reimburses schools and institutions for the milk they serve. In 2008, 4,676 schools and residential child care institutions participated, along with…

  1. Telecommunications in Special Education.

    Science.gov (United States)

    Education Turnkey Systems, Inc., Falls Church, VA.

    One of four reports designed to assess the current state of new technologies, the document reviews the present and future 5-year status of telecommunication technologies in regular and special education. Briefly described are technological and economic aspects of videotex/teletext, subscription services, satellite broadcasting, cable television,…

  2. Research Article Special Issue

    African Journals Online (AJOL)

    2016-07-16

    Jul 16, 2016 ... In contrast to human resources or physical capital, social capital refers ... interaction plays the main role and bears the most responsibility. ..... Based on Special Value of Customer's Satisfaction: Case Study: the Industry of Iran Mobile. Phone Services in Boushehr, Scientific and Research Quarterly Journal ...

  3. Research Article Special Issue

    African Journals Online (AJOL)

    2016-05-15

    May 15, 2016 ... because he didn't have a good memory thereof, but his compulsory ... of specific musical terms; attention to the Quran and Ahl al-Bayt and special devotion ... language, regardless of its hobby effects, has some other benefits, ...

  4. Mediation in Special Education.

    Science.gov (United States)

    Fielding, Pamela S.

    1990-01-01

    This article presents a perspective for viewing mediation in resolving conflicts between parents and school personnel about the education of handicapped students. The appropriateness of mediation as well as its limitations are discussed, as are current uses of mediation in special education and legal problems and issues arising from its use.…

  5. Acceleration and Special Relativity

    CERN Document Server

    Yahalomi, E M

    2000-01-01

    The integration of acceleration over time before reaching the uniformvelocity turns out to be the source of all the special relativity effects. Itexplains physical phenomena like clocks comparisons. The equations forspace-time, mass and energy are presented. This phenomenon complements theexplanation for the twins paradox. A Universal reference frame is obtained.

  6. Research Article Special Issue

    African Journals Online (AJOL)

    2016-05-15

    May 15, 2016 ... customer's satisfaction and its impact on c ... ultimately, 135 questionnaires were analyze ... customer loyalty and customer satisfaction. ... One of the advantages of the high special value of brand is the .... n and buy goods and services ..... R, 2000, Service Quality Perspectives and Satisfaction in Private.

  7. The Special Purpose Vehicle

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    2013-01-01

    The purpose of this article is to investigate whether the situation where two companies appear as originators or sponsors behind a Special Purpose Vehicle (SPV) can be described as a merger, although on micro scale. Are the underlying grounds behind the creation of an SPV much different than thos...

  8. Handbook of Special Education

    Science.gov (United States)

    Kauffman, James M., Ed.; Hallahan, Daniel P., Ed.

    2011-01-01

    Special education is now an established part of public education in the United States--by law and by custom. However, it is still widely misunderstood and continues to be dogged by controversies related to such things as categorization, grouping, assessment, placement, funding, instruction, and a variety of legal issues. The purpose of this…

  9. How a membrane agent buys goods in a membrane store

    Institute of Scientific and Technical Information of China (English)

    Rudolf Freund; Marion Oswald; Thomas Schirk

    2007-01-01

    In this paper we consider a specific model of membrane systems, i.e. membrane systems with attributes. In these systems, the information is placed at the membranes in form of attributes, no objects are considered inside the membranes except for other membranes. The membrane system with attributes evolves according to rules that compute new values for the attributes from the attributes assigned to the membranes involved in the rule. The model of membrane systems with attributes allows us to specify business transactions in a precise way and to simulate different models for such transactions with a suitable tool for membrane systems with attributes.

  10. C metric: the equatorial plane and Fermi coordinates

    CERN Document Server

    Bini, Donato; Filippi, Simonetta; Geralico, Andrea

    2014-01-01

    We discuss geodesic motion in the vacuum C metric using Bondi-like spherical coordinates, with special attention to the role played by the "equatorial plane." We show that the spatial trajectory of photons on such a hypersurface is formally the same of photons on the equatorial plane of the Schwarzschild spacetime, apart from an energy shift involving the spacetime acceleration parameter. Furthermore, we show that photons starting their motion from this hypersurface with vanishing component of the momentum along $\\theta$, remain confined on it, differently from the case of massive particles. This effect is shown to have a counterpart also in the massless limit of the C metric, i.e. in Minkowski spacetime. Finally, we give the explict map between Bondi-like spherical coordinates and Fermi coordinates (up to the second order) for the world line of an observer at rest at a fixed spatial point of the equatorial plane of the C metric, a result which may be eventually useful to estimate both the mass and the accele...

  11. Modeling to Evaluate Coordination and Flexibility in Aluminum Recycling Operations

    Science.gov (United States)

    Brommer, Tracey; Olivetti, Elsa; Fjeldbo, Snorre; Kirchain, Randolph

    Reprocessing of aluminum production byproducts or dross for use in secondary production presents a particular challenge to the aluminum industry. While use of these non-traditional secondary materials is of interest due to their reduced energy and economic burden over virgin counterparts, these materials necessitate the use of particular furnaces, specialized handling and processing conditions. Therefore, to make use of them firms may pursue use of an intermediate recycling facility that can reprocess the secondary materials into a liquid product. After reprocessing downstream aluminum remelters could incorporate the liquid products into their aluminum alloy production schedules. Energy and environmental benefits result from delivering the products as liquid but coordination challenges result because of the energy cost to maintain the liquid. Further coordination challenges result from the need to establish long term recycling production plans in the presence of long term downstream aluminum remelter production uncertainty and inherent variation in the daily order schedule of the downstream aluminum remelters. In this context a fundamental question arises, considering the metallurgical complexities of dross reprocessing, what is the value of operating a coordinated set of by-product reprocessing plants and remelting cast houses?

  12. Sports Specialization, Part II

    Science.gov (United States)

    Myer, Gregory D.; Jayanthi, Neeru; DiFiori, John P.; Faigenbaum, Avery D.; Kiefer, Adam W.; Logerstedt, David; Micheli, Lyle J.

    2016-01-01

    Context: Many coaches, parents, and children believe that the best way to develop elite athletes is for them to participate in only 1 sport from an early age and to play it year-round. However, emerging evidence to the contrary indicates that efforts to specialize in 1 sport may reduce opportunities for all children to participate in a diverse year-round sports season and can lead to lost development of lifetime sports skills. Early sports specialization may also reduce motor skill development and ongoing participation in games and sports as a lifestyle choice. The purpose of this review is to employ the current literature to provide evidence-based alternative strategies that may help to optimize opportunities for all aspiring young athletes to maximize their health, fitness, and sports performance. Evidence Acquisition: Nonsystematic review with critical appraisal of existing literature. Study Design: Clinical review. Level of Evidence: Level 4. Conclusion: Based on the current evidence, parents and educators should help provide opportunities for free unstructured play to improve motor skill development and youth should be encouraged to participate in a variety of sports during their growing years to influence the development of diverse motor skills. For those children who do choose to specialize in a single sport, periods of intense training and specialized sport activities should be closely monitored for indicators of burnout, overuse injury, or potential decrements in performance due to overtraining. Last, the evidence indicates that all youth should be involved in periodized strength and conditioning (eg, integrative neuromuscular training) to help them prepare for the demands of competitive sport participation, and youth who specialize in a single sport should plan periods of isolated and focused integrative neuromuscular training to enhance diverse motor skill development and reduce injury risk factors. Strength of Recommendation Taxonomy (SORT): B. PMID

  13. CFD Analysis and Design of Multi-tubular Membrane Reactor for Dehydrogenation of Cyclohexane

    National Research Council Canada - National Science Library

    Mimura, Kenichi; Yoshida, Naoki; Sato, Takafumi; Itoh, Naotsugu

    2010-01-01

    ...%, are of special interest. To recover high purity hydrogen from such chemical carriers, the palladium membrane reactor is expected to be more efficient than the conventional fixed bed type of equilibrium reactor...

  14. Impairments of social motor coordination in schizophrenia.

    Directory of Open Access Journals (Sweden)

    Manuel Varlet

    Full Text Available It has been demonstrated that motor coordination of interacting people plays a crucial role in the success of social exchanges. Abnormal movements have been reported during interpersonal interactions of patients suffering from schizophrenia and a motor coordination breakdown could explain this social interaction deficit, which is one of the main and earliest features of the illness. Using the dynamical systems framework, the goal of the current study was (i to investigate whether social motor coordination is impaired in schizophrenia and (ii to determine the underlying perceptual or cognitive processes that may be affected. We examined intentional and unintentional social motor coordination in participants oscillating hand-held pendulums from the wrist. The control group consisted of twenty healthy participant pairs while the experimental group consisted of twenty participant pairs that included one participant suffering from schizophrenia. The results showed that unintentional social motor coordination was preserved while intentional social motor coordination was impaired. In intentional coordination, the schizophrenia group displayed coordination patterns that had lower stability and in which the patient never led the coordination. A coupled oscillator model suggests that the schizophrenia group coordination pattern was due to a decrease in the amount of available information together with a delay in information transmission. Our study thus identified relational motor signatures of schizophrenia and opens new perspectives for detecting the illness and improving social interactions of patients.

  15. Medicaid Managed Care Structures and Care Coordination.

    Science.gov (United States)

    Gilchrist-Scott, Douglas H; Feinstein, James A; Agrawal, Rishi

    2017-09-01

    Child enrollment in Medicaid managed care (MMC) has expanded dramatically, primarily through state mandates. Care coordination is a key metric in MMC evaluation because it drives much of the proposed cost savings and may be associated with improved health outcomes and utilization. We evaluated the relationships between enrollment in 2 MMC structures, primary care case management (PCCM) and health maintenance organization (HMO) and access to and receipt of care coordination by children. Using data from the 2011/2012 National Survey of Children's Health and the Medicaid Statistical Information System state data mart, we conducted a retrospective, cross-sectional analysis of the relationships between fee-for-service, PCCM or HMO enrollment, and access to and receipt of care coordination. State-level univariate analyses and individual and state multilevel multivariable analyses evaluated correlations between MMC enrollment and care coordination, controlling for demographic characteristics and state financing levels. In univariate and multilevel multivariable analyses, the PCCM penetration rate was significantly associated with increased access to care coordination (adjusted odds ratio: 1.23, P = .034) and receipt of care coordination (adjusted odds ratio: 1.37, P = .02). The HMO penetration rate was significantly associated with lower access to care coordination (adjusted odds ratio: 0.85, P = .05) and receipt of care coordination (adjusted odds ratio: 0.71, P coordination may be more effective in PCCM than HMO structures. States should consider care coordination outcomes when structuring their Medicaid programs. Copyright © 2017 by the American Academy of Pediatrics.

  16. Coordination control of distributed systems

    CERN Document Server

    Villa, Tiziano

    2015-01-01

    This book describes how control of distributed systems can be advanced by an integration of control, communication, and computation. The global control objectives are met by judicious combinations of local and nonlocal observations taking advantage of various forms of communication exchanges between distributed controllers. Control architectures are considered according to  increasing degrees of cooperation of local controllers:  fully distributed or decentralized control,  control with communication between controllers,  coordination control, and multilevel control.  The book covers also topics bridging computer science, communication, and control, like communication for control of networks, average consensus for distributed systems, and modeling and verification of discrete and of hybrid systems. Examples and case studies are introduced in the first part of the text and developed throughout the book. They include: control of underwater vehicles, automated-guided vehicles on a container terminal, contro...

  17. Tree Formation Using Coordinate Method

    Directory of Open Access Journals (Sweden)

    Monika Choudhary

    2015-06-01

    Full Text Available In this paper we are introducing a new method of tree formation, we propose a coordinate based method by which we can store and access tree structures. As we know in NLP, parsing is the most important module. The output of this module is generally parsed trees. Currently, TAG (Tree Adjoining Grammar is widely used grammar due to its linguistic and formal nature. It is simply tree generating system. The unit structure used in TAG is structured trees. So we used our new method to store trees where we worked on English to Hindi language. We worked on different sentences from English to Hindi, our method is the easiest way to manipulate tree. We have implemented within small corpus and for finite number of structures and further can be extended in future.

  18. PTPRR, cerebellum, and motor coordination.

    Science.gov (United States)

    Schmitt, Ina; Bitoun, Emmanuelle; Manto, Mario

    2009-06-01

    Tyrosine phosphorylation is a powerful mechanism of modulation for proliferation, differentiation, and functioning of neurons. The protein products of the neuronal mouse gene PTPRR are physiological regulators of mitogen-activated protein kinase (MAPK) activities. PTPRR(-/-) mice display deficits of motor coordination and balance skills. PTPRR gene orthologues are found in many vertebrates. Recent observations suggest that the human episodic ataxia 2 (EA2) and spinocerebellar ataxia types 6 (SCA6), 12 (SCA12), and 14 (SCA14) might be associated with impaired phosphorylation levels of cerebellum calcium channels and receptors. The concept that MAPK signaling is a key process in tuning synaptic plasticity in cerebellar circuits is now emerging, with numerous implications for understanding cerebellar functions and cerebellar disorders.

  19. Immobilization of silver in polypropylene membrane for anti-biofouling performance.

    Science.gov (United States)

    Zhu, Xiaoying; Tang, Lin; Wee, Kin-Ho; Zhao, Yong-Hong; Bai, Renbi

    2011-08-01

    In this study, a method was developed to immobilize silver onto polypropylene (PP) membrane surfaces for improved anti-biofouling performance. A commercial PP membrane was first grafted with the thiol functional groups, and then silver ions were immobilized onto the PP membrane surface through coordinating with the thiol groups. The immobilized silver was found to be very stable, with only ~1.1% of the immobilized silver being leached out during a leaching test. The surface of the modified membrane (PPS-Ag) was examined with ATR-FTIR and XPS analysis, which verified the successful grafting of the thiol groups and the coordination of silver ions on the membrane surface. The surface properties of the membrane were also characterized by SEM, AFM and water contact angle measurements. The PPS-Ag membrane was found to have a smoother and more hydrophilic surface than the PP membrane. Both Gram-negative bacteria, Escherichia coli, and Gram-positive bacteria, Staphylococcus aureus, were used to evaluate the antibacterial and anti-biofouling performance of the PPS-Ag membrane. From disk diffusion experiments, the PPS-Ag membrane exhibited the capability of inhibiting the growth of both the Gram-negative and Gram-positive bacteria tested. The anti-biofouling performance of the membrane was assessed by immersion in a mixed suspension of E. coli and S. aureus and filtration tests. The PPS-Ag membrane showed a stable and significantly enhanced anti-biofouling performance as compared with the PP membrane. The results in this study demonstrate that biofouling of a PP membrane can be sufficiently overcome through immobilizing silver onto the membrane surface.

  20. The necessity of the second postulate in special relativity

    CERN Document Server

    Drory, Alon

    2014-01-01

    Many authors noted that the principle of relativity together with space-time homogeneity and isotropy restrict the form of the coordinate transformations from one inertial frame to another to being Lorentz-like. The equations contain a free parameter, $k$ (equal to $c^{-2}$ in special relativity), which value is claimed to be merely an empirical matter, so that special relativity does not need the postulate of constancy of the speed of light. I analyze this claim and argue that the distinction between the cases $k = 0$ and $k \

  1. The Specialized school in time of inclusion

    Directory of Open Access Journals (Sweden)

    Roseli Albino dos Santos

    2014-04-01

    Full Text Available This study has the objective to investigate the meanings about school inclusion and disability, produced by a group of professionals engaged in a specialized school located in a city in the state of São Paulo. The metodology used was semi-structured and structured interviews with the director of the institution, two pedagogical coordinators and five teachers. Data were subjected to a descriptive-interpretative analysis. The results indicated that professionals attribute the responsibility for self development, only to students with intellectual disabilities . The emphasis of the speeches falls on the inability of the student and the immutability of disability. It is observed that the narratives do not reveal critical positioning of professional educational processes involving this population. The professionals who work in specialized institution still have a conception of disability based on the inability of the student and, despite defending the right of these students to school inclusion, these professionals still manifest fear of what they will find outside the walls of the institution, revealing attitudes and overprotection ignorance of the role of specialized institution in times of inclusion. We conclude that the conceptions about intellectual disability and inclusive education presented by professionals can contribute much more to the reiteration of school exclusion, historically focused on this population than for its actual inclusion in the school system of education.

  2. Special relativity at the quantum scale.

    Science.gov (United States)

    Lam, Pui K

    2014-01-01

    It has been suggested that the space-time structure as described by the theory of special relativity is a macroscopic manifestation of a more fundamental quantum structure (pre-geometry). Efforts to quantify this idea have come mainly from the area of abstract quantum logic theory. Here we present a preliminary attempt to develop a quantum formulation of special relativity based on a model that retains some geometric attributes. Our model is Feynman's "checker-board" trajectory for a 1-D relativistic free particle. We use this model to guide us in identifying (1) the quantum version of the postulates of special relativity and (2) the appropriate quantum "coordinates". This model possesses a useful feature that it admits an interpretation both in terms of paths in space-time and in terms of quantum states. Based on the quantum version of the postulates, we derive a transformation rule for velocity. This rule reduces to the Einstein's velocity-addition formula in the macroscopic limit and reveals an interesting aspect of time. The 3-D case, time-dilation effect, and invariant interval are also discussed in term of this new formulation. This is a preliminary investigation; some results are derived, while others are interesting observations at this point.

  3. Electrospinning of PVDF nanofibrous membranes with controllable crystalline phases

    Science.gov (United States)

    Lei, Tingping; Zhu, Ping; Cai, Xiaomei; Yang, Le; Yang, Fan

    2015-07-01

    Effectively controlling crystalline phases of electrospun polyvinylidene fluoride (PVDF) nanofibers is crucial to produce membranes with special properties for specific applications. Here, the heating treatment during or after electrospinning has been investigated to determine an effective way to control crystalline phase of PVDF nanofibers. By simultaneously controlling the collector temperature and the flow rate during the fiber deposition, a comparatively lower temperature (≤70 °C) is required for obtaining α-, β-, or γ-phase-dominant nanofibrous membranes, whereas a much higher temperature (≥150 °C) is necessary for post-heating of already-deposited fibers. On the other hand, through finely tuning the heating during or after electrospinning, crosslinked nanofibrous membranes can be also obtained, which undoubtedly enhance mechanical performance of the membranes. Therefore, it is hopeful to fabricate high-performance electrospun PVDF nanofibrous membranes with synchronous control of crystalline phases and morphologies, which will further broaden the applications of PVDF materials.

  4. Triangle-hinge models for unoriented membranes

    Science.gov (United States)

    Fukuma, Masafumi; Sugishita, Sotaro; Umeda, Naoya

    2016-07-01

    Triangle-hinge models [M. Fukuma, S. Sugishita, and N. Umeda, J. High Energy Phys. 1507, 088 (2015)] are introduced to describe worldvolume dynamics of membranes. The Feynman diagrams consist of triangles glued together along hinges and can be restricted to tetrahedral decompositions in a large-N limit. In this paper, after clarifying that all the tetrahedra resulting in the original models are orientable, we define a version of triangle-hinge models that can describe the dynamics of unoriented membranes. By regarding each triangle as representing a propagation of an open membrane of disk topology, we introduce a local worldvolume parity transformation which inverts the orientation of a triangle, and define unoriented triangle-hinge models by gauging the transformation. Unlike two-dimensional cases, this local transformation generally relates a manifold to a nonmanifold, but still is a well-defined manipulation among tetrahedral decompositions. We further show that matter fields can be introduced in the same way as in the original oriented models. In particular, the models will describe unoriented membranes in a target spacetime by taking matter fields to be the target space coordinates.

  5. Membrane-mediated interaction between strongly anisotropic protein scaffolds.

    Directory of Open Access Journals (Sweden)

    Yonatan Schweitzer

    2015-02-01

    Full Text Available Specialized proteins serve as scaffolds sculpting strongly curved membranes of intracellular organelles. Effective membrane shaping requires segregation of these proteins into domains and is, therefore, critically dependent on the protein-protein interaction. Interactions mediated by membrane elastic deformations have been extensively analyzed within approximations of large inter-protein distances, small extents of the protein-mediated membrane bending and small deviations of the protein shapes from isotropic spherical segments. At the same time, important classes of the realistic membrane-shaping proteins have strongly elongated shapes with large and highly anisotropic curvature. Here we investigated, computationally, the membrane mediated interaction between proteins or protein oligomers representing membrane scaffolds with strongly anisotropic curvature, and addressed, quantitatively, a specific case of the scaffold geometrical parameters characterizing BAR domains, which are crucial for membrane shaping in endocytosis. In addition to the previously analyzed contributions to the interaction, we considered a repulsive force stemming from the entropy of the scaffold orientation. We computed this interaction to be of the same order of magnitude as the well-known attractive force related to the entropy of membrane undulations. We demonstrated the scaffold shape anisotropy to cause a mutual aligning of the scaffolds and to generate a strong attractive interaction bringing the scaffolds close to each other to equilibrium distances much smaller than the scaffold size. We computed the energy of interaction between scaffolds of a realistic geometry to constitute tens of kBT, which guarantees a robust segregation of the scaffolds into domains.

  6. Determination of tetracycline in milk by using nucleotide/lanthanide coordination polymer-based ternary complex.

    Science.gov (United States)

    Tan, Hongliang; Ma, Chanjiao; Song, Yonghai; Xu, Fugang; Chen, Shouhui; Wang, Li

    2013-12-15

    The meta-organic coordination polymers have been emerged as fascinating nanomaterials because of their tunable nature. In this work, we employed lanthanide coordination polymer self-assembled from adenosine monophosphate (AMP) and europium ion (Eu(3+)) as receptor reagent and citrate (Cit) as ancillary ligand to construct a fluorescent sensor for the detection of tetracycline (Tc) in milk. The co-coordination of Cit and Tc with Eu(3+) on the surface of the coordination polymer AMP/Eu leads to the formation of ternary complex which emitted strong fluorescence due to the removal of coordinated water molecules and an intramolecular energy transfer from Tc to Eu(3+). The fluorescent intensity of Eu(3+) displayed a good linear response to Tc concentrations in the range of 0.1-20 μM with a detection limit of 60 nM. This method was successfully applied to determine the levels of Tc in milk, which is the first application of coordination polymer as a fluorescent sensor in real sample. Compared with other Eu(3+)-based fluorescent methods for Tc detection, the presented method allows simple, direct analysis of Tc without requiring special reaction media or complicated prepreparation processes. This straightforward strategy could be extended to the preparation of other lanthanide coordination polymer-based fluorescent probes for applications in biosensing, imaging, drug delivery, and so on. Copyright © 2013 Elsevier B.V. All rights reserved.

  7. Analysis of Arf1 GTPase-dependent membrane binding and remodeling using the exomer secretory vesicle cargo adaptor

    Science.gov (United States)

    Paczkowski, Jon E.; Fromme, J. Christopher

    2016-01-01

    Summary Protein-protein and protein-membrane interactions play a critical role in shaping biological membranes through direct physical contact with the membrane surface. This is particularly evident in many steps of membrane trafficking, in which proteins deform the membrane and induce fission to form transport carriers. The small GTPase Arf1 and related proteins have the ability to remodel membranes by insertion of an amphipathic helix into the membrane. Arf1 and the exomer cargo adaptor coordinate cargo sorting into subset of secretory vesicle carriers in the model organism Saccharomyces cerevisiae. Here, we detail the assays we used to explore the cooperative action of Arf1 and exomer to bind and remodel membranes. We expect these methods are broadly applicable to other small GTPase/effector systems where investigation of membrane binding and remodeling is of interest. PMID:27632000

  8. Plasma membrane ATPases

    DEFF Research Database (Denmark)

    Palmgren, Michael Broberg; Bækgaard, Lone; Lopez Marques, Rosa Laura

    2011-01-01

    The plasma membrane separates the cellular contents from the surrounding environment. Nutrients must enter through the plasma membrane in order to reach the cell interior, and toxic metabolites and several ions leave the cell by traveling across the same barrier. Biological pumps in the plasma me...

  9. Thin supported silica membranes

    NARCIS (Netherlands)

    Zivkovic, Tijana

    2007-01-01

    This thesis discusses several transport-related aspects relevant for the application of thin supported silica membranes for gas separation and nanofiltration. The influence of support geometry on overall membrane performance is investigated. Planar (i.e., flat plate), tubular, and multichannel suppo

  10. Membrane capacitive deionization

    NARCIS (Netherlands)

    Biesheuvel, P.M.; Wal, van der A.

    2010-01-01

    Membrane capacitive deionization (MCDI) is an ion-removal process based on applying an electrical potential difference across an aqueous solution which flows in between oppositely placed porous electrodes, in front of which ion-exchange membranes are positioned. Due to the applied potential, ions ar

  11. Observing joint action: Coordination creates commitment.

    Science.gov (United States)

    Michael, John; Sebanz, Natalie; Knoblich, Günther

    2016-12-01

    Previous research has shown that interpersonal coordination enhances pro-social attitudes and behavior. Here, we extend this research by investigating whether the degree of coordination observed in a joint action enhances the perception of individuals' commitment to the joint action. In four experiments, participants viewed videos of joint actions. In the low coordination condition, two agents made independent individual contributions to a joint action. In the high coordination condition, the individual contributions were tightly linked. Participants judged whether and for how long the observed agents would resist a tempting outside option and remain engaged in the joint action. The results showed that participants were more likely to expect agents to resist outside options when observing joint actions with a high degree of coordination. This indicates that observing interpersonal coordination is sufficient to enhance the perception of commitment to joint action. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Control coordination abilities in shock combat sports

    Directory of Open Access Journals (Sweden)

    Natalya Boychenko

    2014-12-01

    Full Text Available Purpose: optimize the process control level of coordination abilities in martial arts. Material and Methods: analysis and compilation of scientific and methodological literature, interviews with coaches of drum martial arts, video analysis techniques, teacher observations. Results: identified specific types of coordination abilities in shock combat sports. Pod branny and offered specific and nonspecific tests to monitor the level of species athletes coordination abilities. Conclusion: it is determined that in order to achieve victory in the fight martial artists to navigate the space to be able to assess and manage dynamic and spatio-temporal parameters of movements, maintain balance, have a high coordination of movements. The proposed tests to monitor species coordination abilities athletes allow an objective assessment of not only the overall level of coordination, and the level of specific types of manifestations of this ability.

  13. Characteristics of Trivalent Lanthanides in Coordination Chemistry

    Institute of Scientific and Technical Information of China (English)

    Xue Dongfeng(薛冬峰); Zuo Sen(左森); Henryk Ratajczak

    2004-01-01

    Some basic characteristics of lanthanide-oxygen bonds in various trivalent lanthanide metal-organic complexes are quantitatively studied by the bond valence model. Some important relationships among the electronegativity, bond valence parameter, bond length and lanthanide coordination number in these complexes are generally found , which show that for each trivalent lanthanide cation all calculated parameters may well be correlated with its coordination number in their coordination complexes. Specifically,32 new data for the bond valence parameter are first calculated in this work.An approximate linear relationship between the Ln-O bond valence parameter and the coordination number of Ln3+ is obtained.The Ln-O bond length increases with the increase in the lanthanide coordination number.The difference of electronegative values decreases with the increase in the lanthanide coordination number.

  14. Increased coordination in public transport – which mechanisms are available?

    DEFF Research Database (Denmark)

    Sørensen, Claus Hedegaard; Longva, Frode

    2011-01-01

    After several years of New Public Management reforms within public transport, coordination seems to receive increased attention. With examples of actual as well as suggested changes taken from Denmark, Sweden and the UK the aim of the article is to analyse and classify the mechanisms utilized...... and suggested to increase coordination between core stakeholders within passenger railway services and bus services. Four distinctive mechanisms of coordination are suggested, namely organisational coordination, contractual coordination, partnership coordination and discursive coordination. Each coordination...

  15. Membrane projection lithography

    Energy Technology Data Exchange (ETDEWEB)

    Burckel, David Bruce; Davids, Paul S; Resnick, Paul J; Draper, Bruce L

    2015-03-17

    The various technologies presented herein relate to a three dimensional manufacturing technique for application with semiconductor technologies. A membrane layer can be formed over a cavity. An opening can be formed in the membrane such that the membrane can act as a mask layer to the underlying wall surfaces and bottom surface of the cavity. A beam to facilitate an operation comprising any of implantation, etching or deposition can be directed through the opening onto the underlying surface, with the opening acting as a mask to control the area of the underlying surfaces on which any of implantation occurs, material is removed, and/or material is deposited. The membrane can be removed, a new membrane placed over the cavity and a new opening formed to facilitate another implantation, etching, or deposition operation. By changing the direction of the beam different wall/bottom surfaces can be utilized to form a plurality of structures.

  16. Ion-conducting membranes

    Energy Technology Data Exchange (ETDEWEB)

    Masel, Richard L.; Chen, Qingmei; Liu, Zengcai; Kutz, Robert

    2016-06-21

    An ion conducting polymeric composition mixture comprises a copolymer of styrene and vinylbenzyl-R.sub.s. R.sub.s is selected from the group consisting of imidazoliums and pyridiniums. The composition contains 10%-90% by weight of vinylbenzyl-R.sub.s. The composition can further comprise a polyolefin comprising substituted polyolefins, a polymer comprising cyclic amine groups, a polymer comprising at least one of a phenylene group and a phenyl group, a polyamide, and/or the reaction product of a constituent having two carbon-carbon double bonds. The composition can be in the form of a membrane. In a preferred embodiment, the membrane is a Helper Membrane that increases the faradaic efficiency of an electrochemical cell into which the membrane is incorporated, and also allows product formation at lower voltages than in cells without the Helper Membrane.

  17. Ion-conducting membranes

    Energy Technology Data Exchange (ETDEWEB)

    Masel, Richard I.; Chen, Qingmei; Liu, Zengcai; Kutz, Robert

    2017-02-28

    An ion conducting polymeric composition mixture comprises a copolymer of styrene and vinylbenzyl-R.sub.s. R.sub.s is selected from the group consisting of imidazoliums, pyridiniums, pyrazoliums, pyrrolidiniums, pyrroliums, pyrimidiums, piperidiniums, indoliums, and triaziniums. The composition contains 10%-90% by weight of vinylbenzyl-R.sub.s. The composition can further comprise a polyolefin comprising substituted polyolefins, a polymer comprising cyclic amine groups, a polymer comprising at least one of a phenylene group and a phenyl group, a polyamide, and/or the reaction product of a constituent having two carbon-carbon double bonds. The composition can be in the form of a membrane. In a preferred embodiment, the membrane is a Helper Membrane that increases the faradaic efficiency of an electrochemical cell into which the membrane is incorporated, and also allows product formation at lower voltages than in cells without the Helper Membrane.

  18. Non-Brownian diffusion in lipid membranes: Experiments and simulations.

    Science.gov (United States)

    Metzler, R; Jeon, J-H; Cherstvy, A G

    2016-10-01

    The dynamics of constituents and the surface response of cellular membranes-also in connection to the binding of various particles and macromolecules to the membrane-are still a matter of controversy in the membrane biophysics community, particularly with respect to crowded membranes of living biological cells. We here put into perspective recent single particle tracking experiments in the plasma membranes of living cells and supercomputing studies of lipid bilayer model membranes with and without protein crowding. Special emphasis is put on the observation of anomalous, non-Brownian diffusion of both lipid molecules and proteins embedded in the lipid bilayer. While single component, pure lipid bilayers in simulations exhibit only transient anomalous diffusion of lipid molecules on nanosecond time scales, the persistence of anomalous diffusion becomes significantly longer ranged on the addition of disorder-through the addition of cholesterol or proteins-and on passing of the membrane lipids to the gel phase. Concurrently, experiments demonstrate the anomalous diffusion of membrane embedded proteins up to macroscopic time scales in the minute time range. Particular emphasis will be put on the physical character of the anomalous diffusion, in particular, the occurrence of ageing observed in the experiments-the effective diffusivity of the measured particles is a decreasing function of time. Moreover, we present results for the time dependent local scaling exponent of the mean squared displacement of the monitored particles. Recent results finding deviations from the commonly assumed Gaussian diffusion patterns in protein crowded membranes are reported. The properties of the displacement autocorrelation function of the lipid molecules are discussed in the light of their appropriate physical anomalous diffusion models, both for non-crowded and crowded membranes. In the last part of this review we address the upcoming field of membrane distortion by elongated membrane

  19. Correlation of general and special physical training of athletes cheerleaders at the stage the specialized training base

    Directory of Open Access Journals (Sweden)

    Lutsenko L.S.

    2013-12-01

    Full Text Available Objective: to determine the most informative parameters of athletes in cheerleading. The experiment involved 14 athletes (age 16-18 years. To assess the physical fitness of the special developed 20 tests. The possibilities of creating favorable conditions for optimization of the training process and the achievement of high performance sports. Recommended special training to use the funds for the development of coordination abilities. In the general fitness should pay attention to the development and improvement of the spatial-temporal characteristics, the ability to navigate the space and to maintain equilibrium, co-ordination of movement, flexibility, power, speed and speed- strength abilities. Found that the success of the competitive activities of athletes depend on a rational balance of informative indicators.

  20. Managing interteam coordination within and between organizations

    OpenAIRE

    de Vries, Thomas Arend

    2015-01-01

    To accomplish complex tasks and effectively respond to environmental contingencies, teams must coordinate task-related issues with other teams (i.e., interteam coordination). Regrettably, interteam coordination is often complicated by misunderstandings that can arise from differences in teams’ languages, routines, and goals. In this dissertation I examine organizational structures, team composition strategies, and individual team member characteristics that can help to overcome such difficult...