WorldWideScience

Sample records for controlling fusion alpha

  1. Alfven Eigenmode And Ion Bernstein Wave Studies For Controlling Fusion Alpha Particles

    CERN Document Server

    Heeter, R F

    1999-01-01

    In magnetic confinement fusion reactor plasmas, the charged fusion products (such as alpha particles in deuterium-tritium plasmas) will be the dominant power source, and by controlling these charged fusion products using wave-particle interactions the reactor performance could be optimized. This thesis studies two candidate waves: Mode-Converted Ion Bernstein Waves (MCIBWs) and Alfvén Eigenmodes (AEs). Rates of MCIBW-driven losses of alpha-like fast deuterons, previously observed in the Tokamak Fusion Test Reactor (TFTR), are reproduced by a new model so that the wave-particle diffusion coefficient can be deduced. The MCIBW power in TFTR is found to be ∼ 1/3 that needed for collisionless alpha particle control. A reasonable reactor power scaling is derived. To study AEs, existing magnetic fluctuation probes at the Joint European Torus (JET) have been absolutely calibrated from 30–500 kHz for the first time, allowing fluctuation measurements with &vbm0;dBpol&vbm0;/B0&am...

  2. Alpha-nucleus potential for alpha-decay and sub-barrier fusion

    CERN Document Server

    Denisov, V Y

    2005-01-01

    The set of parameters for alpha-nucleus potential is derived by using the data for both the alpha-decay half-lives and the fusion cross-sections around the barrier for reactions alpha+40Ca, alpha+59Co, alpha+208Pb. The alpha-decay half-lives are obtained in the framework of a cluster model using the WKB approximation. The evaluated alpha-decay half-lives and the fusion cross-sections agreed well with the data. Fusion reactions between alpha-particle and heavy nuclei can be used for both the formation of very heavy nuclei and spectroscopic studies of the formed compound nuclei.

  3. Alpha-nucleus potential for alpha-decay and sub-barrier fusion

    OpenAIRE

    Denisov, V. Yu.; Ikezoe, H.

    2005-01-01

    The set of parameters for alpha-nucleus potential is derived by using the data for both the alpha-decay half-lives and the fusion cross-sections around the barrier for reactions alpha+40Ca, alpha+59Co, alpha+208Pb. The alpha-decay half-lives are obtained in the framework of a cluster model using the WKB approximation. The evaluated alpha-decay half-lives and the fusion cross-sections agreed well with the data. Fusion reactions between alpha-particle and heavy nuclei can be used for both the f...

  4. Quantum controlled fusion

    Science.gov (United States)

    Berrios, Eduardo; Gruebele, Martin; Wolynes, Peter G.

    2017-09-01

    Quantum-controlled motion of nuclei, starting from the nanometer-size ground state of a molecule, can potentially overcome some of the difficulties of thermonuclear fusion by compression of a fuel pellet or in a bulk plasma. Coherent laser control can manipulate nuclear motion precisely, achieving large phase space densities for the colliding nuclei. We combine quantum wavepacket propagation of D and T nuclei in a field-bound molecule with coherent control by a shaped laser pulse to demonstrate enhancement of nuclear collision rates. Atom-smashers powered by coherent control may become laboratory sources of particle bursts, and even assist muonic fusion.

  5. Lyman Alpha Control

    CERN Document Server

    Nielsen, Daniel Stefaniak

    2015-01-01

    This document gives an overview of how to operate the Lyman Alpha Control application written in LabVIEW along with things to watch out for. Overview of the LabVIEW code itself as well as the physical wiring of and connections from/to the NI PCI-6229 DAQ box is also included. The Lyman Alpha Control application is the interface between the ALPHA sequencer and the HighFinesse Wavelength Meter as well as the Lyman Alpha laser setup. The application measures the wavelength of the output light from the Lyman Alpha cavity through the Wavelength Meter. The application can use the Wavelength Meter’s PID capabilities to stabilize the Lyman Alpha laser output as well as switch between up to three frequencies.

  6. Alpha Heating and Burning Plasmas in Inertial Confinement Fusion

    Science.gov (United States)

    Betti, R.; Christopherson, A. R.; Bose, A.; Woo, K. M.

    2016-05-01

    Assessing the degree to which fusion alpha particles contribute to the fusion yield is essential to understanding the onset of the thermal runaway process of thermonuclear ignition. It is shown that in inertial confinement fusion, the yield enhancement due to alpha particle heating (before ignition occurs) depends on the generalized Lawson parameter that can be inferred from experimental observables. A universal curve valid for arbitrary laser-fusion targets shows the yield amplification due to alpha heating for a given value of the Lawson parameter. The same theory is used to determine the onset of the burning plasma regime when the alpha heating exceeds the compression work. This result can be used to assess the performance of current ignition experiments at the National Ignition Facility.

  7. Alpha Particle Physics Experiments in the Tokamak Fusion Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Budny, R.V.; Darrow, D.S.; Medley, S.S.; Nazikian, R.; Zweben, S.J.; et al.

    1998-12-14

    Alpha particle physics experiments were done on the Tokamak Fusion Test Reactor (TFTR) during its deuterium-tritium (DT) run from 1993-1997. These experiments utilized several new alpha particle diagnostics and hundreds of DT discharges to characterize the alpha particle confinement and wave-particle interactions. In general, the results from the alpha particle diagnostics agreed with the classical single-particle confinement model in magnetohydrodynamic (MHD) quiescent discharges. Also, the observed alpha particle interactions with sawteeth, toroidal Alfvén eigenmodes (TAE), and ion cyclotron resonant frequency (ICRF) waves were roughly consistent with theoretical modeling. This paper reviews what was learned and identifies what remains to be understood.

  8. Controlled fusion and plasma physics

    CERN Document Server

    Miyamoto, Kenro

    2006-01-01

    Resulting from ongoing, international research into fusion processes, the International Tokamak Experimental Reactor (ITER) is a major step in the quest for a new energy source.The first graduate-level text to cover the details of ITER, Controlled Fusion and Plasma Physics introduces various aspects and issues of recent fusion research activities through the shortest access path. The distinguished author breaks down the topic by first dealing with fusion and then concentrating on the more complex subject of plasma physics. The book begins with the basics of controlled fusion research, foll

  9. Controlled Nuclear Fusion.

    Science.gov (United States)

    Glasstone, Samuel

    This publication is one of a series of information booklets for the general public published by The United States Atomic Energy Commission. Among the topics discussed are: Importance of Fusion Energy; Conditions for Nuclear Fusion; Thermonuclear Reactions in Plasmas; Plasma Confinement by Magnetic Fields; Experiments With Plasmas; High-Temperature…

  10. Controlled thermonuclear fusion

    CERN Document Server

    Bobin, Jean Louis

    2014-01-01

    The book is a presentation of the basic principles and main achievements in the field of nuclear fusion. It encompasses both magnetic and inertial confinements plus a few exotic mechanisms for nuclear fusion. The state-of-the-art regarding thermonuclear reactions, hot plasmas, tokamaks, laser-driven compression and future reactors is given.

  11. Plasma physics for controlled fusion

    CERN Document Server

    Miyamoto, Kenro

    2016-01-01

    This new edition presents the essential theoretical and analytical methods needed to understand the recent fusion research of tokamak and alternate approaches. The author describes magnetohydrodynamic and kinetic theories of cold and hot plasmas in detail. The book covers new important topics for fusion studies such as plasma transport by drift turbulence, which depend on the magnetic configuration and zonal flows. These are universal phenomena of microturbulence. They can modify the onset criterion for turbulent transport, instabilities driven by energetic particles as well as alpha particle generation and typical plasma models for computer simulation. The fusion research of tokamaks with various new versions of H modes are explained. The design concept of ITER, the international tokamak experimental reactor, is described for inductively driven operations as well as steady-state operations using non-inductive drives. Alternative approaches of reversed-field pinch and its relaxation process, stellator includi...

  12. Control of Fusion and Solubility in Fusion Systems

    CERN Document Server

    Craven, David A

    2009-01-01

    In this article, we consider the control of fusion in fusion systems, proving three previously known, non-trivial results in a new, largely elementary way. We then reprove a result of Aschbacher, that the product of two strongly closed subgroups is strongly closed; to do this, we consolidate the theory of quotients of fusion systems into a consistent theory. We move on considering p-soluble fusion systems, and prove that they are constrained, allowing us to effectively characterize fusion systems of p-soluble groups. This leads us to recast Thompson Factorization for Qd(p)-free fusion systems, and consider Thompson Factorization for more general fusion systems.

  13. Controlled fusion and plasma physics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    This document presents the several speeches that took place during the 22nd European Physical Society conference on Controlled Fusion and Plasma Physics in Bournemouth, UK, between the 2nd and 7th July 1995. The talks deal with new experiments carried out on several tokamaks, particularly Tore Supra, concerning plasma confinement and fusion. Some information on specific fusion devices or tokamak devices is provided, as well as results of experiments concerning plasma instability. Separate abstracts were prepared for all the 31 papers in this volume. (TEC).

  14. Plasma physics for controlled fusion. 2. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Miyamoto, Kenro

    2016-08-01

    This new edition presents the essential theoretical and analytical methods needed to understand the recent fusion research of tokamak and alternate approaches. The author describes magnetohydrodynamic and kinetic theories of cold and hot plasmas in detail. The book covers new important topics for fusion studies such as plasma transport by drift turbulence, which depend on the magnetic configuration and zonal flows. These are universal phenomena of microturbulence. They can modify the onset criterion for turbulent transport, instabilities driven by energetic particles as well as alpha particle generation and typical plasma models for computer simulation. The fusion research of tokamaks with various new versions of H modes are explained. The design concept of ITER, the international tokamak experimental reactor, is described for inductively driven operations as well as steady-state operations using non-inductive drives. Alternative approaches of reversed-field pinch and its relaxation process, stellator including quasi-symmetric system, open-end system of tandem mirror and inertial confinement are also explained. Newly added and updated topics in this second edition include zonal flows, various versions of H modes, and steady-state operations of tokamak, the design concept of ITER, the relaxation process of RFP, quasi-symmetric stellator, and tandem mirror. The book addresses graduate students and researchers in the field of controlled fusion.

  15. GAMMA-RAY DIAGNOSTICS OF ALPHA-SLOWING IN INERTIAL CONFINEMENT FUSION-TARGETS

    NARCIS (Netherlands)

    DENDOOVEN, PG; DRAKE, RP; CABLE, MD; Dendooven, Peter

    1993-01-01

    For large inertial confinement fusion deuterium-tritium targets, a way to diagnose alpha slowing might be via capture reaction gamma rays. Calculations are presented for two such methods: one uses the alpha+T direct capture gamma rays, the other is based on a series of resonant alpha-capture reactio

  16. GAMMA-RAY DIAGNOSTICS OF ALPHA-SLOWING IN INERTIAL CONFINEMENT FUSION-TARGETS

    NARCIS (Netherlands)

    DENDOOVEN, PG; DRAKE, RP; CABLE, MD; Dendooven, Peter

    1993-01-01

    For large inertial confinement fusion deuterium-tritium targets, a way to diagnose alpha slowing might be via capture reaction gamma rays. Calculations are presented for two such methods: one uses the alpha+T direct capture gamma rays, the other is based on a series of resonant alpha-capture

  17. Fusion performances and alpha heating in future JET D-T plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Balet, B.; Cordey, J.G.; Gibson, A.; Lomas, P.; Stubberfield, P.M.; Thomas, P. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking

    1994-07-01

    The new pump divertor installed at JET should allow high performance pulses of a few seconds duration by both preventing the impurity influx and controlling the density evolution. The TRANSP code has been used in a predictive mode to assess the possible fusion performance of such plasmas fuelled with a 50:50 mixture of D and T, and the effect of alpha particles heating on Te and Ti. Several cases are considered: 50:50 D-T mix; 50:50 D-T mix, no C bloom; 50:50 D-T mix, VH phase, density control; 50:50 D-T mix, VH phase, density control, 6 Ma. The predictions show that if the the bloom and MHD instabilities can be controlled at higher plasma currents using a higher toroidal field to keep a reasonable beta value, then a higher fusion performance steady state plasma with Q{sub DT} superior to 2.5 should be possible. The alpha heating power of 4.9 MW would lead to a 74% increase in Te. 4 refs., 4 figs., 1 tab.

  18. Plasma Physics and Controlled Nuclear Fusion

    Science.gov (United States)

    Fisch, N. J.

    2010-01-01

    Already while making his famous contributions in uncontrolled nuclear fusion for wartime uses, Edward Teller contemplated how the abundant energy release through nuclear fusion might serve peacetime uses as well. His legacy in controlled nuclear fusion, and the associated physics of plasmas, spans both magnetic and inertial confinement approaches. His contributions in plasma physics, both the intellectual and the administrative, continue to impact the field.

  19. Controlled Nuclear Fusion: Status and Outlook

    Science.gov (United States)

    Rose, David J.

    1971-01-01

    Presents the history, current concerns and potential developments of nuclear fusion as a major energy source. Controlled fusion research is summarized, technological feasibility is discussed and environmental factors are examined. Relationships of alternative energy sources as well as energy utilization are considered. (JM)

  20. On the approximations of the distribution function of fusion alpha particles

    Energy Technology Data Exchange (ETDEWEB)

    Bilato, R., E-mail: roberto.bilato@ipp.mpg.de; Brambilla, M.; Poli, E. [Max Planck Institute for Plasma Physics, EURATOM Association, Boltzmannstr. 2, 85748 Garching (Germany)

    2014-10-15

    The solution of the drift-kinetic equation for fusion-born alpha particles is derived in the limit of dominant parallel streaming, and it is related to the usual slowing-down distribution function. The typical approximations of the fast tail of fusion-born alpha particles are briefly compared and discussed. In particular, approximating the distribution function of fast-alpha particles with an “equivalent” Maxwellian is inaccurate to describe absorption of radio-frequency waves in the ion-cyclotron range of frequencies.

  1. Impact of ICRH on the measurement of fusion alphas by collective Thomson scattering in ITER

    DEFF Research Database (Denmark)

    Salewski, Mirko; Eriksson, L.-G.; Bindslev, Henrik

    2009-01-01

    Collective Thomson scattering (CTS) has been proposed for measuring the phase space distributions of confined fast ion populations in ITER plasmas. This study determines the impact of fast ions accelerated by ion cyclotron resonance heating (ICRH) on the ability of CTS to diagnose fusion alphas......, corresponding to an off-axis resonance. The sensitivities of the results to the He-3 concentration (0.1-4%) and the heating power (20-40 MW) are considered. Fusion born alphas dominate the total CTS signal for large Doppler shifts of the scattered radiation. The tritons generate a negligible fraction...... perpendicular velocities, it may be difficult to draw conclusions about the physics of alpha particles alone by CTS. With this exception, the CTS diagnostic can reveal the physics of the fusion alphas in ITER even under the presence of fast ions due to ICRH....

  2. Plasma Physics and Controlled Nuclear Fusion

    CERN Document Server

    Miyamoto, Kenro

    2005-01-01

    The primary objectives of this book are, firstly, to present the essential theoretical background needed to understand recent fusion research and, secondly, to describe the current status of fusion research for graduate students and senior undergraduates. It will also serve as a useful reference for scientists and engineers working in the related fields. In Part I, Plasma Physics, the author explains the basics of magneto-hydrodynamics and kinetic theory in a simple and compact way and, at the same time, covers important new topics for fusion studies such as the ballooning representation, instabilities driven by energetic particles and various plasma models for computer simulations. Part II, Controlled Nuclear Fusion, attempts to review the "big picture" in fusion research. All important phenomena and technologies are addressed, with a particular emphasis on the topics of most concern in current research.

  3. Estimation of the {alpha} particles and neutron distribution generated during a fusion reaction; Evaluation de la distribution des particules {alpha} et des neutrons issus de la reaction de fusion

    Energy Technology Data Exchange (ETDEWEB)

    Dellacherie, S.

    1997-12-01

    The respective distributions (or density probabilities) of {alpha} particles and neutrons have been modeled using a Monte-Carlo method for the thermonuclear fusion reaction D + T {yields} {alpha} + n + 17.6 MeV. (N.T.).

  4. Inertially confined fusion plasmas dominated by alpha-particle self-heating

    Science.gov (United States)

    Hurricane, O. A.; Callahan, D. A.; Casey, D. T.; Dewald, E. L.; Dittrich, T. R.; Döppner, T.; Haan, S.; Hinkel, D. E.; Berzak Hopkins, L. F.; Jones, O.; Kritcher, A. L.; Le Pape, S.; Ma, T.; Macphee, A. G.; Milovich, J. L.; Moody, J.; Pak, A.; Park, H.-S.; Patel, P. K.; Ralph, J. E.; Robey, H. F.; Ross, J. S.; Salmonson, J. D.; Spears, B. K.; Springer, P. T.; Tommasini, R.; Albert, F.; Benedetti, L. R.; Bionta, R.; Bond, E.; Bradley, D. K.; Caggiano, J.; Celliers, P. M.; Cerjan, C.; Church, J. A.; Dylla-Spears, R.; Edgell, D.; Edwards, M. J.; Fittinghoff, D.; Barrios Garcia, M. A.; Hamza, A.; Hatarik, R.; Herrmann, H.; Hohenberger, M.; Hoover, D.; Kline, J. L.; Kyrala, G.; Kozioziemski, B.; Grim, G.; Field, J. E.; Frenje, J.; Izumi, N.; Gatu Johnson, M.; Khan, S. F.; Knauer, J.; Kohut, T.; Landen, O.; Merrill, F.; Michel, P.; Moore, A.; Nagel, S. R.; Nikroo, A.; Parham, T.; Rygg, R. R.; Sayre, D.; Schneider, M.; Shaughnessy, D.; Strozzi, D.; Town, R. P. J.; Turnbull, D.; Volegov, P.; Wan, A.; Widmann, K.; Wilde, C.; Yeamans, C.

    2016-08-01

    Alpha-particle self-heating, the process of deuterium-tritium fusion reaction products depositing their kinetic energy locally within a fusion reaction region and thus increasing the temperature in the reacting region, is essential for achieving ignition in a fusion system. Here, we report new inertial confinement fusion experiments where the alpha-particle heating of the plasma is dominant with the fusion yield produced exceeding the fusion yield from the work done on the fuel (pressure times volume change) by a factor of two or more. These experiments have achieved the highest yield (26 +/- 0.5 kJ) and stagnation pressures (≍220 +/- 40 Gbar) of any facility-based inertial confinement fusion experiments, although they are still short of the pressures required for ignition on the National Ignition Facility (~300-400 Gbar). These experiments put us in a new part of parameter space that has not been extensively studied so far because it lies between the no-alpha-particle-deposition regime and ignition.

  5. Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

    Science.gov (United States)

    Alcalay, M; Zangrilli, D; Fagioli, M; Pandolfi, P P; Mencarelli, A; Lo Coco, F; Biondi, A; Grignani, F; Pelicci, P G

    1992-01-01

    Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL)-specific reciprocal translocation of chromosomes 15 and 17 [t(15;17)]. PML-RAR alpha is expressed as a fusion protein. We investigated the organization and expression pattern of the RAR alpha-PML gene in a series of APL patients representative of the molecular heterogeneity of the t(15;17) and found (i) two types of RAR alpha-PML mRNA junctions (RAR alpha exon 2/PML exon 4 or RAR alpha exon 2/PML exon 7) that maintain the RAR alpha and PML longest open reading frames aligned and are the result of chromosome 15 breaking at two different sites; and (ii) 10 different RAR alpha-PML fusion transcripts that differ for the assembly of their PML coding exons. A RAR alpha-PML transcript was present in most, but not all, APL patients. Images PMID:1317574

  6. Fokker Planck kinetic modeling of suprathermal alpha-particles in a fusion plasma

    CERN Document Server

    Peigney, Benjamin-Edouard; Tikhonchuk, Vladimir

    2014-01-01

    We present an ion kinetic model describing the ignition and burn of the deuterium-tritium fuel of inertial fusion targets. The analysis of the underlying physical model enables us to develop efficient numerical methods to simulate the creation, transport and collisional relaxation of fusion reaction products (alpha-particles) at a kinetic level. A two-energy-scale approach leads to a self-consistent modeling of the coupling between suprathermal alpha-particles and the thermal bulk of the imploding plasma. This method provides an accurate numerical treatment of energy deposition and transport processes involving suprathermal particles. The numerical tools presented here are validated against known analytical results. This enables us to investigate the potential role of ion kinetic effects on the physics of ignition and thermonuclear burn in inertial confinement fusion schemes.

  7. Plasma surface interactions in controlled fusion devices

    Energy Technology Data Exchange (ETDEWEB)

    Ghendrih, Ph.; Becoulet, M.; Costanzo, L. [and others

    2000-07-01

    This report brings together all the contributions of EURATOM/CEA association to the 14. international conference on plasma surface interactions in controlled fusion devices. 24 papers are presented and they deal mainly with the ergodic divertor and the first wall of Tore-supra tokamak.

  8. Simulations of alpha parameters in a TFTR DT supershot with high fusion power

    Energy Technology Data Exchange (ETDEWEB)

    Budny, R.V.; Bell, M.G.; Janos, A.C. [and others

    1995-07-01

    A TFTR supershot with a plasma current of 2.5 MA, neutral beam heating power of 33.7 MW, and a peak DT fusion power of 7.5 MW is studied using the TRANSP plasma analysis code. Simulations of alpha parameters such as the alpha heating, pressure, and distributions in energy and v{sub parallel}/v are given. The effects of toroidal ripple and mixing of the fast alpha particles during the sawteeth observed after the neutral beam injection phase are modeled. The distributions of alpha particles on the outer midplane are peaked near forward and backward v{sub parallel}/v. Ripple losses deplete the distributions in the vicinity of v{sub parallel}/v {approximately}{minus}0.4. Sawtooth mixing of fast alpha particles is computed to reduce their central density and broaden their width in energy.

  9. Linear optimal control of tokamak fusion devices

    Energy Technology Data Exchange (ETDEWEB)

    Kessel, C.E.; Firestone, M.A.; Conn, R.W.

    1989-05-01

    The control of plasma position, shape and current in a tokamak fusion reactor is examined using linear optimal control. These advanced tokamaks are characterized by non up-down symmetric coils and structure, thick structure surrounding the plasma, eddy currents, shaped plasmas, superconducting coils, vertically unstable plasmas, and hybrid function coils providing ohmic heating, vertical field, radial field, and shaping field. Models of the electromagnetic environment in a tokamak are derived and used to construct control gains that are tested in nonlinear simulations with initial perturbations. The issues of applying linear optimal control to advanced tokamaks are addressed, including complex equilibrium control, choice of cost functional weights, the coil voltage limit, discrete control, and order reduction. Results indicate that the linear optimal control is a feasible technique for controlling advanced tokamaks where the more common classical control will be severely strained or will not work. 28 refs., 13 figs.

  10. Alpha-muon sticking and chaos in muon-catalysed d-t fusion

    CERN Document Server

    Kimura, S; Kimura, Sachie; Bonasera, Aldo

    2006-01-01

    We discuss the alpha-muon sticking coefficient in the muon-catalysed d-t fusion in the framework of the Constrained Molecular Dynamics model. Especially the influence of muonic chaotic dynamics on the sticking coefficient is brought into focus. The chaotic motion of the muon affects not only the fusion cross section but also the $\\mu-\\alpha$ sticking coefficient. Chaotic systems lead to larger enhancements with respect to regular systems because of the reduction of the tunneling region. Moreover they give smaller sticking probabilities than those of regular events. By utilizing a characteristic of the chaotic dynamics one can avoid losing the muon in the $\\mu$CF cycle. We propose that the application of the so-called "microwave ionization of a Rydberg atom" to the present case could lead to the enhancement of the reactivation process by using X-rays.

  11. Hepatoma cell-specific ganciclovir-mediated toxicity of a lentivirally transduced HSV-TkEGFP fusion protein gene placed under the control of rat alpha-fetoprotein gene regulatory sequences.

    Science.gov (United States)

    Uch, Rathviro; Gérolami, René; Faivre, Jamila; Hardwigsen, Jean; Mathieu, Sylvie; Mannoni, Patrice; Bagnis, Claude

    2003-09-01

    Suicide gene therapy combining herpes simplex virus thymidine kinase gene transfer and ganciclovir administration can be envisioned as a powerful therapeutical approach in the treatment of hepatocellular carcinoma; however, safety issues regarding transgene expression in parenchyma cells have to be addressed. In this study, we constructed LATKW, a lentiviral vector expressing the HSV-TkEGFP gene placed under the control of the promoter elements that control the expression of the rat alpha-fetoprotein, and assayed its specific expression in vitro in hepatocarcinoma and nonhepatocarcinoma human cell lines, and in epidermal growth factor stimulated human primary hepatocytes. Using LATKW, a strong expression of the transgene was found in transduced hepatocarcinoma cells compared to a very low expression in nonhepatocarcinoma human cell lines, as assessed by Northern blot, RT-PCR, FACS analysis and ganciclovir-mediated toxicity assay, and no expression was found in lentivirally transduced normal human hepatocytes. Altogether, these results demonstrate the possibility to use a lentivirally transduced expression unit containing the rat alpha-fetoprotein promoter to restrict the HSV-TK-mediated induced GCV sensitivity to human hepatocarcinoma cells.

  12. Polarized fuel for controlled thermonuclear fusion

    Science.gov (United States)

    Bartalucci, Sergio

    2017-07-01

    The use of polarized nuclei as a fuel for thermonuclear fusion reactors was suggested more than 30 years ago, providing evidence for a significant increase of the total cross section. In particular, an enhancement factor close to 1.5 is expected in the energy range below 100 keV for the dominant nuclear fusion reactions 2H + 3H → 4He + n + 17.58 MeV and 2H + 3He → 4He + p + 18.34 MeV. Furthermore, the use of polarized fuel allows one to control the ejectile trajectories, via an enhancement in the forward-backward cross section asymmetry due to polarization. This allows some control on the energy transfer from the plasma to the reactor wall or helps concentrate the neutron flux to defined wall areas. Nevertheless, this idea was received with skepticism by the relevant scientific community, due to some uncertainty in the physics of the process, the low efficiency in the production of polarized beams for injection into plasma and the apparent difficulty of preserving the ion polarization for a time long compared with nuclear burning time. But more recently, as a consequence of significant progress in the field of atomic beam sources and polarized targets, the interest in this matter has been refreshed for both inertially and magnetically confined plasmas. The possibility of implementing nuclear polarization in present and future fusion reactors is discussed in this paper. In particular, the interaction between polarized ions and magnetic fields, both static and RF, which are typically used in a Tokamak for plasma heating via ion cyclotron resonance (ICRH), is considered. Also, experimental issues for practically performing a feasibility test on a real fusion reactors are illustrated.

  13. Sensor fusion for intelligent process control.

    Energy Technology Data Exchange (ETDEWEB)

    Connors, John J. (PPG Industries, Inc., Harmar Township, PA); Hill, Kevin (PPG Industries, Inc., Harmar Township, PA); Hanekamp, David (PPG Industries, Inc., Harmar Township, PA); Haley, William F. (PPG Industries, Inc., Wichita Falls, TX); Gallagher, Robert J.; Gowin, Craig (PPG Industries, Inc., Batavia, IL); Farrar, Arthur R. (PPG Industries, Inc., Wichita Falls, TX); Sheaffer, Donald A.; DeYoung, Mark A. (PPG Industries, Inc., Mt. Zion, IL); Bertram, Lee A.; Dodge, Craig (PPG Industries, Inc., Mt. Zion, IL); Binion, Bruce (PPG Industries, Inc., Mt. Zion, IL); Walsh, Peter M.; Houf, William G.; Desam, Padmabhushana R. (University of Utah, Salt Lake City, UT); Tiwary, Rajiv (PPG Industries, Inc., Harmar Township, PA); Stokes, Michael R. (PPG Industries, Inc.); Miller, Alan J. (PPG Industries, Inc., Mt. Zion, IL); Michael, Richard W. (PPG Industries, Inc., Lincoln, AL); Mayer, Raymond M. (PPG Industries, Inc., Harmar Township, PA); Jiao, Yu (PPG Industries, Inc., Harmar Township, PA); Smith, Philip J. (University of Utah, Salt Lake City, UT); Arbab, Mehran (PPG Industries, Inc., Harmar Township, PA); Hillaire, Robert G.

    2004-08-01

    An integrated system for the fusion of product and process sensors and controls for production of flat glass was envisioned, having as its objective the maximization of throughput and product quality subject to emission limits, furnace refractory wear, and other constraints. Although the project was prematurely terminated, stopping the work short of its goal, the tasks that were completed show the value of the approach and objectives. Though the demonstration was to have been done on a flat glass production line, the approach is applicable to control of production in the other sectors of the glass industry. Furthermore, the system architecture is also applicable in other industries utilizing processes in which product uniformity is determined by ability to control feed composition, mixing, heating and cooling, chemical reactions, and physical processes such as distillation, crystallization, drying, etc. The first phase of the project, with Visteon Automotive Systems as industrial partner, was focused on simulation and control of the glass annealing lehr. That work produced the analysis and computer code that provide the foundation for model-based control of annealing lehrs during steady state operation and through color and thickness changes. In the second phase of the work, with PPG Industries as the industrial partner, the emphasis was on control of temperature and combustion stoichiometry in the melting furnace, to provide a wider operating window, improve product yield, and increase energy efficiency. A program of experiments with the furnace, CFD modeling and simulation, flow measurements, and sensor fusion was undertaken to provide the experimental and theoretical basis for an integrated, model-based control system utilizing the new infrastructure installed at the demonstration site for the purpose. In spite of the fact that the project was terminated during the first year of the second phase of the work, the results of these first steps toward implementation

  14. Fusion

    Science.gov (United States)

    Herman, Robin

    1990-10-01

    The book abounds with fascinating anecdotes about fusion's rocky path: the spurious claim by Argentine dictator Juan Peron in 1951 that his country had built a working fusion reactor, the rush by the United States to drop secrecy and publicize its fusion work as a propaganda offensive after the Russian success with Sputnik; the fortune Penthouse magazine publisher Bob Guccione sank into an unconventional fusion device, the skepticism that met an assertion by two University of Utah chemists in 1989 that they had created "cold fusion" in a bottle. Aimed at a general audience, the book describes the scientific basis of controlled fusion--the fusing of atomic nuclei, under conditions hotter than the sun, to release energy. Using personal recollections of scientists involved, it traces the history of this little-known international race that began during the Cold War in secret laboratories in the United States, Great Britain and the Soviet Union, and evolved into an astonishingly open collaboration between East and West.

  15. Primary exploration of nonlinear information fusion control theory

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    By introducing information fusion techniques into a control field, a new theory of information fusion control (IFC) is proposed. Based on the theory of information fusion estimation, optimal control of nonlinear discrete control system is investigated. All information on control strategy, including ideal control strategy, expected object trajectory and dynamics of system, are regarded as measuring information of control strategy. Therefore, the problem of optimal control is transferred into the one of information fusion estimation. Firstly, the nonlinear information fusion estimation theorems are described. Secondly, an algorithm of nonlinear IFC theory is detailedly deduced. Finally, the simulation results of manipulator shift control are given, which show the feasibility and effectiveness of the presented algorithm.

  16. K-alpha conversion efficiency measurments for x-ray scattering in inertial confinement fusion plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Kritcher, A L; Neumayer, P; Urry, M K; Robey, H; Niemann, C; Landen, O L; Morse, E; Glenzer, S H

    2006-11-21

    The conversion efficiency of ultra short-pulse laser radiation to K-{alpha} x-rays has been measured for various chlorine-containing targets to be used as x-ray scattering probes of dense plasmas. The spectral and temporal properties of these sources will allow spectrally-resolved x-ray scattering probing with picosecond temporal resolution required for measuring the plasma conditions in inertial confinement fusion experiments. Simulations of x-ray scattering spectra from these plasmas show that fuel capsule density, capsule ablator density, and shock timing information may be inferred.

  17. Core conditions for alpha heating attained in direct-drive inertial confinement fusion

    Science.gov (United States)

    Bose, A.; Woo, K. M.; Betti, R.; Campbell, E. M.; Mangino, D.; Christopherson, A. R.; McCrory, R. L.; Nora, R.; Regan, S. P.; Goncharov, V. N.; Sangster, T. C.; Forrest, C. J.; Frenje, J.; Gatu Johnson, M.; Glebov, V. Yu; Knauer, J. P.; Marshall, F. J.; Stoeckl, C.; Theobald, W.

    2016-07-01

    It is shown that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available on the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independent of the uncertainties in the physical mechanism that degrade implosions on OMEGA, and relies solely on a volumetric scaling of the experimentally observed core conditions. It is estimated that the current best-performing OMEGA implosion [Regan et al., Phys. Rev. Lett. 117, 025001 (2016), 10.1103/PhysRevLett.117.025001] extrapolated to a 1.9 MJ laser driver with the same illumination configuration and laser-target coupling would produce 125 kJ of fusion energy with similar levels of alpha heating observed in current highest performing indirect-drive NIF implosions.

  18. Core conditions for alpha heating attained in direct-drive inertial confinement fusion.

    Science.gov (United States)

    Bose, A; Woo, K M; Betti, R; Campbell, E M; Mangino, D; Christopherson, A R; McCrory, R L; Nora, R; Regan, S P; Goncharov, V N; Sangster, T C; Forrest, C J; Frenje, J; Gatu Johnson, M; Glebov, V Yu; Knauer, J P; Marshall, F J; Stoeckl, C; Theobald, W

    2016-07-01

    It is shown that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available on the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independent of the uncertainties in the physical mechanism that degrade implosions on OMEGA, and relies solely on a volumetric scaling of the experimentally observed core conditions. It is estimated that the current best-performing OMEGA implosion [Regan et al., Phys. Rev. Lett. 117, 025001 (2016)10.1103/PhysRevLett.117.025001] extrapolated to a 1.9 MJ laser driver with the same illumination configuration and laser-target coupling would produce 125 kJ of fusion energy with similar levels of alpha heating observed in current highest performing indirect-drive NIF implosions.

  19. Introduction to plasma physics and controlled fusion

    CERN Document Server

    Chen, Francis F

    1984-01-01

    This complete introduction to plasma physics and controlled fusion by one of the pioneering scientists in this expanding field offers both a simple and intuitive discussion of the basic concepts of this subject and an insight into the challenging problems of current research. In a wholly lucid manner the work covers single-particle motions, fluid equations for plasmas, wave motions, diffusion and resistivity, Landau damping, plasma instabilities and nonlinear problems. For students, this outstanding text offers a painless introduction to this important field; for teachers, a large collection of problems; and for researchers, a concise review of the fundamentals as well as original treatments of a number of topics never before explained so clearly. This revised edition contains new material on kinetic effects, including Bernstein waves and the plasma dispersion function, and on nonlinear wave equations and solitons.

  20. Microstructural refinement of weld fusion zones in {alpha}-{beta} titanium alloys using pulsed current welding

    Energy Technology Data Exchange (ETDEWEB)

    Sundaresan, S.; Janaki Ram, G.D. [Indian Inst. of Technol., Chennai (India). Dept. of Metallurgical Engineering; Madhusudhan Reddy, G. [Defence Metallurgical Research Lab., Hyderabad (India)

    1999-04-01

    Pulsing of the welding current is one approach for refining the fusion zone grain structure in {alpha}-{beta} titanium alloy welds. This paper reports work in which gas tungsten-arc welds were produced in two {alpha}-{beta} titanium alloys under a variety of conditions including direct current (d.c.) pulsing and alternating current (a.c.) pulsing. The results show that, while d.c. pulsing did also refine the weld metal {beta} grain structure, the effect of a.c. pulsing was much greater. Current pulsing enhances fluid flow, reduces temperature gradients and causes a continual change in the weld pool size and shape. These effects, which are believed to be responsible for refining the solidification structure, are much stronger in a.c. pulsing than in d.c. pulsing. The observed grain refinement was shown to result in an appreciable increase in fusion zone tensile ductility. Post-weld heat treatment improved ductility both in pulsed and unpulsed welds, but pulsed welds showed greater tensile elongation even in the heat treated condition. (orig.) 27 refs.

  1. Closed loop control of the sawtooth instability in nuclear fusion

    NARCIS (Netherlands)

    Witvoet, G.; Steinbuch, M.; Westerhof, E.; Doelman, N.J.; Baar, M.R. de

    2010-01-01

    In nuclear fusion the sawtooth instability is an important plasma phenomenon, having both positive and negative effects on the tokamak plasma. Control of its period is essential in future nuclear fusion reactors. This paper presents a control oriented model of the sawtooth instability, with current

  2. Closed loop control of the sawtooth instability in nuclear fusion

    NARCIS (Netherlands)

    Witvoet, G.; Steinbuch, M.; Westerhof, E.; Doelman, N.J.; Baar, M.R. de

    2010-01-01

    In nuclear fusion the sawtooth instability is an important plasma phenomenon, having both positive and negative effects on the tokamak plasma. Control of its period is essential in future nuclear fusion reactors. This paper presents a control oriented model of the sawtooth instability, with current

  3. Fusion Control of Flexible Logic Control and Neural Network

    Directory of Open Access Journals (Sweden)

    Lihua Fu

    2014-01-01

    Full Text Available Based on the basic physical meaning of error E and error variety EC, this paper analyzes the logical relationship between them and uses Universal Combinatorial Operation Model in Universal Logic to describe it. Accordingly, a flexible logic control method is put forward to realize effective control on multivariable nonlinear system. In order to implement fusion control with artificial neural network, this paper proposes a new neuron model of Zero-level Universal Combinatorial Operation in Universal Logic. And the artificial neural network of flexible logic control model is implemented based on the proposed neuron model. Finally, stability control, anti-interference control of double inverted-pendulum system, and free walking of cart pendulum system on a level track are realized, showing experimentally the feasibility and validity of this method.

  4. Introduction to plasma physics and controlled fusion

    CERN Document Server

    Chen, Francis F

    2016-01-01

    The third edition of this classic text presents a complete introduction to plasma physics and controlled fusion, written by one of the pioneering scientists in this expanding field.  It offers both a simple and intuitive discussion of the basic concepts of the subject matter and an insight into the challenging problems of current research. This outstanding text offers students a painless introduction to this important field; for teachers, a large collection of problems; and for researchers, a concise review of the fundamentals as well as original treatments of a number of topics never before explained so clearly.  In a wholly lucid manner the second edition covered charged-particle motions, plasmas as fluids, kinetic theory, and nonlinear effects.  For the third edition, two new chapters have been added to incorporate discussion of more recent advances in the field.  The new chapter 9 on Special Plasmas covers non-neutral plasmas, pure electron plasmas, solid and ultra-cold plasmas, pair-ion plasmas, d...

  5. Multiscale modeling study of pulsed damage accumulation in alpha-Fe under inertial fusion conditions

    CERN Document Server

    Perlado, J M; Dominguez, E; Prieto, J; Caturla, M J; Díaz de la Rubia, T

    2002-01-01

    Reduced activation ferritic-martensitic (RAFM) steels are being considered as candidate materials for the first structural wall of a future fusion reactor, due to their high resistance to neutron irradiation. A combination of molecular dynamics and kinetic Monte Carlo has been utilized to analyze and assess the change and evolution of the microstructure in irradiated alpha-Fe, the main component of RAFM steels. We discuss how the pulse frequency, 1 and 10 Hz, may affect the damage production and accumulation. Dose rates of 0.1 and 0.01 dpa/s will be considered in order to represent the damage suffered by a protected first structural wall. These results will be compared with previous work on the subject and with those achieved with continuous irradiation at similar average dose rate.

  6. Controlled cellular fusion using optically trapped plasmonic nano-heaters

    Science.gov (United States)

    Bahadori, Azra; Lund, Andreas R.; Semsey, Szabolcs; Oddershede, Lene B.; Bendix, Poul M.

    2016-09-01

    Optically trapped plasmonic nano-heaters are used to mediate efficient and controlled fusion of biological membranes. The fusion method is demonstrated by optically trapping plasmonic nanoparticles located in between vesicle membranes leading to rapid lipid and content mixing. As an interesting application we show how direct control over fusion can be used for studying diffusion of peripheral membrane proteins and their interactions with membranes and for studying protein reactions. Membrane proteins encapsulated in an inert vesicle can be transferred to a vesicle composed of negative lipids by optically induced fusion. Mixing of the two membranes results in a fused vesicle with a high affinity for the protein and we observe immediate membrane tubulation due to the activity of the protein. Fusion of distinct membrane compartments also has applications in small scale chemistry for realizing pico-liter reactions and offers many exciting applications within biology which are discussed here.

  7. Achievement of Core Conditions for Alpha Heating in Direct-Drive Inertial Confinement Fusion

    Science.gov (United States)

    Bose, A.; Woo, K. M.; Betti, R.; Mangino, D.; Christopherson, A. R.; Theobald, W.; Campbell, E. M.; McCrory, R. L.; Regan, S. P.; Goncharov, V. N.; Sangster, T. C.; Forrest, C. J.; Glebov, V. Yu.; Knauer, J. P.; Marshall, F. J.; Stoeckl, C.; Nora, R.; Frenje, J. A.; Gatu Johnson, M.; Shvarts, D.

    2016-10-01

    It is shown for the first time that direct-drive implosions on the OMEGA laser have achieved core conditions that would lead to significant alpha heating at incident energies available at the National Ignition Facility (NIF) scale. The extrapolation of the experimental results from OMEGA to NIF energy assumes only that the implosion hydrodynamic efficiency is unchanged at higher energies. This approach is independent of the uncertainties in the physical mechanism that degrade implosions on OMEGA, and relies solely on a volumetric scaling of the experimentally observed core conditions. It is estimated that the current best-performing OMEGA implosion extrapolated to a 1.9-MJ laser driver with the same illumination configuration and laser-target coupling would produce 125 kJ of fusion energy with similar levels of alpha heating observed in current highest performing indirect-drive NIF implosions. This conclusion is reached using an analytic scaling as well as direct numerical simulations of energy-scaled targets. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  8. Plasma physics and controlled fusion research during half a century

    Energy Technology Data Exchange (ETDEWEB)

    Lehnert, Bo

    2001-06-01

    A review is given on the historical development of research on plasma physics and controlled fusion. The potentialities are outlined for fusion of light atomic nuclei, with respect to the available energy resources and the environmental properties. Various approaches in the research on controlled fusion are further described, as well as the present state of investigation and future perspectives, being based on the use of a hot plasma in a fusion reactor. Special reference is given to the part of this work which has been conducted in Sweden, merely to identify its place within the general historical development. Considerable progress has been made in fusion research during the last decades. Temperatures above the limit for ignition of self-sustained fusion reactions, i.e. at more than hundred million degrees, have been reached in large experiments and under conditions where the fusion power generation is comparable to the power losses. An energy producing fusion reactor could in principle be realized already today, but it would not become technically and economically efficient when being based on the present state of art. Future international research has therefore to be conducted along broad lines, with necessary ingredients of basic investigations and new ideas.

  9. Tumor necrosis factor-{alpha} enhanced fusions between oral squamous cell carcinoma cells and endothelial cells via VCAM-1/VLA-4 pathway

    Energy Technology Data Exchange (ETDEWEB)

    Song, Kai; Zhu, Fei; Zhang, Han-zhong [The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory for Oral Biomedicine Ministry of Education, Wuhan University, Wuhan (China); Shang, Zheng-jun, E-mail: shangzhengjun@hotmail.com [The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory for Oral Biomedicine Ministry of Education, Wuhan University, Wuhan (China); First Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan (China)

    2012-08-15

    Fusion between cancer cells and host cells, including endothelial cells, may strongly modulate the biological behavior of tumors. However, no one is sure about the driving factors and underlying mechanism involved in such fusion. We hypothesized in this study that inflammation, one of the main characteristics in tumor microenvironment, serves as a prominent catalyst for fusion events. Our results showed that oral cancer cells can fuse spontaneously with endothelial cells in co-culture and inflammatory cytokine tumor necrosis factor-{alpha} (TNF-{alpha}) increased fusion of human umbilical vein endothelium cells and oral cancer cells by up to 3-fold in vitro. Additionally, human oral squamous cell carcinoma cell lines and 35 out of 50 (70%) oral squamous carcinoma specimens express VLA-4, an integrin, previously implicated in fusions between human peripheral blood CD34-positive cells and murine cardiomyocytes. Expression of VCAM-1, a ligand for VLA-4, was evident on vascular endothelium of oral squamous cell carcinoma. Moreover, immunocytochemistry and flow cytometry analysis revealed that expression of VCAM-1 increased obviously in TNF-{alpha}-stimulated endothelial cells. Anti-VLA-4 or anti-VCAM-1 treatment can decrease significantly cancer-endothelial adhesion and block such fusion. Collectively, our results suggested that TNF-{alpha} could enhance cancer-endothelial cell adhesion and fusion through VCAM-1/VLA-4 pathway. This study provides insights into regulatory mechanism of cancer-endothelial cell fusion, and has important implications for the development of novel therapeutic strategies for prevention of metastasis. -- Highlights: Black-Right-Pointing-Pointer Spontaneous oral cancer-endothelial cell fusion. Black-Right-Pointing-Pointer TNF-{alpha} enhanced cell fusions. Black-Right-Pointing-Pointer VCAM-1/VLA-4 expressed in oral cancer. Black-Right-Pointing-Pointer TNF-{alpha} increased expression of VCAM-1 on endothelial cells. Black

  10. BOOK REVIEW: Controlled Fusion and Plasma Physics

    Science.gov (United States)

    Engelmann, F.

    2007-07-01

    This new book by Kenro Miyamoto provides an up-to-date overview of the status of fusion research and the important parts of the underlying plasma physics at a moment where, due to the start of ITER construction, an important step in fusion research has been made and many new research workers will enter the field. For them, and also for interested graduate students and physicists in other fields, the book provides a good introduction into fusion physics as, on the whole, the presentation of the material is quite appropriate for getting acquainted with the field on the basis of just general knowledge in physics. There is overlap with Miyamoto's earlier book Plasma Physics for Nuclear Fusion (MIT Press, Cambridge, USA, 1989) but only in a few sections on subjects which have not evolved since. The presentation is subdivided into two parts of about equal length. The first part, following a concise survey of the physics basis of thermonuclear fusion and of plasmas in general, covers the various magnetic configurations studied for plasma confinement (tokamak; reversed field pinch; stellarator; mirror-type geometries) and introduces the specific properties of plasmas in these devices. Plasma confinement in tokamaks is treated in particular detail, in compliance with the importance of this field in fusion research. This includes a review of the ITER concept and of the rationale for the choice of ITER's parameters. In the second part, selected topics in fusion plasma physics (macroscopic instabilities; propagation of waves; kinetic effects such as energy transfer between waves and particles including microscopic instabilities as well as plasma heating and current drive; transport phenomena induced by turbulence) are presented systematically. While the emphasis is on displaying the essential physics, deeper theoretical analysis is also provided here. Every chapter is complemented by a few related problems, but only partial hints for their solution are given. A selection of

  11. Technical Developments for Harnessing Controlled Fusion

    Science.gov (United States)

    Veres, G.; Zoletnik, S.; Jacob, W.

    This chapter gives the conditions for achieving power production using nuclear fusion reactions. The two basic schemes for plasma confinement, inertial and magnetic, are briefly considered and the present technical solutions are outlined. The physical and chemical processes taking place between the hot plasma and the containing vessel wall are discussed in more detail. At the end of the chapter, the present status of research and the planned future development plans are summarized.

  12. Sensor Fusion of Force and Acceleration for Robot Force Control

    OpenAIRE

    Gámez García, Javier; Robertsson, Anders; Gómez Ortega, Juan; Johansson, Rolf

    2004-01-01

    In this paper, robotic sensor fusion of acceleration and force measurement is considered. We discuss the problem of using accelerometers close to the end-effectors of robotic manipulators and how it may improve the force control performance. We introduce a new model-based observer approach to sensor fusion of information from various different sensors. During contact transition, accelerometers and force sensors play a very important role and it can overcome many of the difficulties of uncerta...

  13. Spectroscopic performance studies of 4H-SiC detectors for fusion alpha-particle diagnostics

    Science.gov (United States)

    Raja, P. Vigneshwara; Akhtar, Jamil; Rao, C. V. S.; Vala, Sudhirsinh; Abhangi, Mitul; Murty, N. V. L. Narasimha

    2017-10-01

    The spectroscopic performances of Schottky barrier diodes (SBDs) and bulk detectors fabricated on n-type epitaxial 4H-SiC and high-purity semi-insulating (HPSI) 4H-SiC substrates are studied using 241Am alpha-particles. The spectral responses of the SBD detectors reveal a good energy resolution of 55 keV FWHM (∼1%) at -60 V, and ∼90% charge collection efficiency (CCE) at -100 V. The collected signal charge is stable with time in the SBD detectors; hence polarization effects are not noticed, indicating the good crystalline quality of the epitaxial 4H-SiC for detector applications. On the contrary, a poor energy resolution of 675 keV FWHM (12.3%) at -400 V and a maximum CCE of 28% at -500 V are obtained for the bulk detectors. Moreover, the CCE is found to decrease with time after the application of bias voltage implying the polarization phenomenon. Accordingly, the steady-state CCE of the bulk detectors at -500V is decreased to 13% from its initial value. The inferior spectral response of the bulk detectors is possibly due to the charge trapping and polarization effects. Furthermore, the neutron irradiation effects on the α-particle spectral response of the detectors are examined up to a fluence of 1011 n/cm2. To study the reliability of the SBD detectors at higher irradiation levels, the 14.1 MeV neutron irradiation induced changes in the electrical characteristics of the SBD are investigated up to a fluence of 2 × 1015n/cm2 by device simulations and the probable degradation in the detector response is analyzed. Finally, the possibility of employing 4H-SiC detectors for the fusion alpha-particle diagnostics is discussed.

  14. Fusion

    CERN Document Server

    Mahaffey, James A

    2012-01-01

    As energy problems of the world grow, work toward fusion power continues at a greater pace than ever before. The topic of fusion is one that is often met with the most recognition and interest in the nuclear power arena. Written in clear and jargon-free prose, Fusion explores the big bang of creation to the blackout death of worn-out stars. A brief history of fusion research, beginning with the first tentative theories in the early 20th century, is also discussed, as well as the race for fusion power. This brand-new, full-color resource examines the various programs currently being funded or p

  15. Effects of alpha stopping power modelling on the ignition threshold in a directly-driven inertial confinement fusion capsule

    Science.gov (United States)

    Temporal, Mauro; Canaud, Benoit; Cayzac, Witold; Ramis, Rafael; Singleton, Robert L.

    2017-05-01

    The alpha-particle energy deposition mechanism modifies the ignition conditions of the thermonuclear Deuterium-Tritium fusion reactions, and constitutes a key issue in achieving high gain in Inertial Confinement Fusion implosions. One-dimensional hydrodynamic calculations have been performed with the code Multi-IFE [R. Ramis, J. Meyer-ter-Vehn, Comput. Phys. Commun. 203, 226 (2016)] to simulate the implosion of a capsule directly irradiated by a laser beam. The diffusion approximation for the alpha energy deposition has been used to optimize three laser profiles corresponding to different implosion velocities. A Monte-Carlo package has been included in Multi-IFE to calculate the alpha energy transport, and in this case the energy deposition uses both the LP [C.K. Li, R.D. Petrasso, Phys. Rev. Lett. 70, 3059 (1993)] and the BPS [L.S. Brown, D.L. Preston, R.L. Singleton Jr., Phys. Rep. 410, 237 (2005)] stopping power models. Homothetic transformations that maintain a constant implosion velocity have been used to map out the transition region between marginally-igniting and high-gain configurations. The results provided by the two models have been compared and it is found that - close to the ignition threshold - in order to produce the same fusion energy, the calculations performed with the BPS model require about 10% more invested energy with respect to the LP model.

  16. Fundamentals of plasma physics and controlled fusion

    Energy Technology Data Exchange (ETDEWEB)

    Miyamoto, Kenro

    2000-10-01

    The present lecture note was written to fill a gap between text books for undergraduates and specific review articles written by specialists for their young colleagues. The note may be divided in three parts. The first part is on basic characteristics of a plasma in a magnetic field. The second part describes plasma confinement and heating with an emphasis on magnetohydrodynamic instabilities. In addition, propagation of plasma waves, plasma heating by electromagnetic waves are given. The third part is devoted to various specific concepts of nuclear fusion. Emphases are placed on toroidal devices, especially on tokamak devices and stellarators. One might feel heavy mathematics glimpsing the present note, especially in the part treating magnetohydrodynamic instabilities. (author)

  17. Information fusion based optimal control for large civil aircraft system.

    Science.gov (United States)

    Zhen, Ziyang; Jiang, Ju; Wang, Xinhua; Gao, Chen

    2015-03-01

    Wind disturbance has a great influence on landing security of Large Civil Aircraft. Through simulation research and engineering experience, it can be found that PID control is not good enough to solve the problem of restraining the wind disturbance. This paper focuses on anti-wind attitude control for Large Civil Aircraft in landing phase. In order to improve the riding comfort and the flight security, an information fusion based optimal control strategy is presented to restrain the wind in landing phase for maintaining attitudes and airspeed. Data of Boeing707 is used to establish a nonlinear mode with total variables of Large Civil Aircraft, and then two linear models are obtained which are divided into longitudinal and lateral equations. Based on engineering experience, the longitudinal channel adopts PID control and C inner control to keep longitudinal attitude constant, and applies autothrottle system for keeping airspeed constant, while an information fusion based optimal regulator in the lateral control channel is designed to achieve lateral attitude holding. According to information fusion estimation, by fusing hard constraint information of system dynamic equations and the soft constraint information of performance index function, optimal estimation of the control sequence is derived. Based on this, an information fusion state regulator is deduced for discrete time linear system with disturbance. The simulation results of nonlinear model of aircraft indicate that the information fusion optimal control is better than traditional PID control, LQR control and LQR control with integral action, in anti-wind disturbance performance in the landing phase. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  18. Quantum design using a multiple internal reflections method in a study of fusion processes in the capture of alpha-particles by nuclei

    CERN Document Server

    Maydanyuk, Sergei P; Belchikov, Sergei V

    2015-01-01

    A high precision method to determine fusion in the capture of $\\alpha$-particles by nuclei is presented. For $\\alpha$-capture by $^{40}{\\rm Ca}$ and $^{44}{\\rm Ca}$, such an approach gives (1) the parameters of the $\\alpha$--nucleus potential and (2) fusion probabilities. This method found new parametrization and fusion probabilities and decreased the error by $41.72$ times for $\\alpha + ^{40}{\\rm Ca}$ and $34.06$ times for $\\alpha + ^{44}{\\rm Ca}$ in a description of experimental data in comparison with existing results. We show that the sharp angular momentum cutoff proposed by Glas and Mosel is a rough approximation, Wong's formula and the Hill-Wheeler approach determine the penetrability of the barrier without a correct consideration of the barrier shape, and the WKB approach gives reduced fusion probabilities. Based on our fusion probability formula, we explain the difference between experimental cross-sections for $\\alpha + ^{40}{\\rm Ca}$ and $\\alpha + ^{44}{\\rm Ca}$, which is connected with the theory ...

  19. Force and Acceleration Sensor Fusion for Compliant Robot Motion Control

    OpenAIRE

    Gámez García, Javier; Robertsson, Anders; Gómez Ortega, Juan; Johansson, Rolf

    2005-01-01

    In this work, we present implementation and experiment of the theory of dynamic force sensing for robotic manipulators, which uses a sensor fusion technique in order to extract the contact force exerted by the end-effector of the manipulator from those measured by a wrist force sensor, which are corrupted by the inertial forces on the end-effector. We propose a new control strategy based on multisensor fusion with three different sensors that is, encoders mounted at each joint of the robot wi...

  20. Integration of multiple sensor fusion in controller design.

    Science.gov (United States)

    Abdelrahman, Mohamed; Kandasamy, Parameshwaran

    2003-04-01

    The main focus of this research is to reduce the risk of a catastrophic response of a feedback control system when some of the feedback data from the system sensors are not reliable, while maintaining a reasonable performance of the control system. In this paper a methodology for integrating multiple sensor fusion into the controller design is presented. The multiple sensor fusion algorithm produces, in addition to the estimate of the measurand, a parameter that measures the confidence in the estimated value. This confidence is integrated as a parameter into the controller to produce fast system response when the confidence in the estimate is high, and a slow response when the confidence in the estimate is low. Conditions for the stability of the system with the developed controller are discussed. This methodology is demonstrated on a cupola furnace model. The simulations illustrate the advantages of the new methodology.

  1. Anomalous loss of DT alpha particles in the Tokamak Fusion Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Herrmann, H.W.

    1997-09-01

    An escaping alpha collector probe has been developed for TFTR`s DT phase. Energy distributions of escaping alphas have been determined by measuring the range of {alpha}-particles implanted into nickel foils located within the alpha collector. Results at 1.0 MA of plasma current are in good agreement with predictions for first orbit alpha loss. Results at 1.8 MA, however, show a significant anomalous loss of partially thermalized alphas (in addition to the expected first orbit loss), which is not observed with the lost alpha scintillator detectors in DT plasmas, but does resemble the anomalous delayed loss seen in DD plasmas. None of the candidate explanations proposed thus far are fully consistent with the anomalous loss observations. An experiment designed to study the effect of plasma major radius shifts on {alpha}-particle loss has led to a better understanding of {alpha}-particle dynamics in tokamaks. Intuitively, one might suppose that confined marginally passing {alpha}-particles forced to move toward higher magnetic field during an inward major radius shift (i.e., compression) would mirror and become trapped particles, leading to increased alpha loss. Such an effect was looked for during the shift experiment, however, no significant changes in alpha loss to the 90{degree} lost alpha scintillator detector were observed during the shifts. It is calculated that the energy gained by an {alpha}-particle during the inward shift is sufficient to explain this result. However, an unexpected loss of partially thermalized {alpha}-particles near the passing/trapped boundary was observed to occur between inward and outward shifts at an intermediate value of plasma current (1.4 MA). This anomalous loss feature is not yet understood.

  2. Rapid Determination of 226Ra and Uranium Isotopes in Solid Samples by Fusion with Lithium Metaborate and Alpha Spectrometry

    Directory of Open Access Journals (Sweden)

    R. Bojanowski

    2002-01-01

    Full Text Available A simple and rapid method has been developed to determine 226Ra in rocks, soils, and sediments. Samples are decomposed by fusion with lithium metaborate and the melt is dissolved in a solution containing sulfates and citric acid. During the dissolution, a fine suspension of mixed barium and radium sulfates is formed. The microcrystals are collected on a membrane filter (pore size 0.1 μm and analysed in an alpha spectrometer. Application of a 133Ba tracer enables us to assess the loss of the analyte, which only rarely exceeds 10%. All analytical operations, beginning from sample decomposition to source preparation for alpha spectrometry, can be accomplished within 1 or 2 h.

  3. Atomic data for controlled fusion research

    Energy Technology Data Exchange (ETDEWEB)

    Barnett, C.F.; Ray, J.A.; Ricci, E.; Wilker, M.I.; McDaniel, E.W.; Thomas, E.W.; Gilbody, H.B.

    1977-02-01

    Presented is an evaluated graphical and tabular compilation of atomic and molecular cross sections of interest to controlled thermonuclear research. The cross sections are tabulated and graphed as a function of energy for collision processes involving heavy particles, electrons, and photons with atoms and ions. Also included are sections on data for particle penetration through macroscopic matter, particle transport properties, particle interactions with surfaces, and pertinent charged particle nuclear cross sections and reaction rates. In most cases estimates have been made of the data accuracy.

  4. Improved Controls for Fusion RF Systems. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Casey, Jeffrey A. [Rockfield Research Inc., Las Vegas, NV (United States)

    2011-11-08

    We have addressed the specific requirements for the integrated systems controlling an array of klystrons used for Lower Hybrid Current Drive (LHCD). The immediate goal for our design was to modernize the transmitter protection system (TPS) for LHCD on the Alcator C-Mod tokamak at the MIT Plasma Science and Fusion Center (MIT-PSFC). Working with the Alcator C-Mod team, we have upgraded the design of these controls to retrofit for improvements in performance and safety, as well as to facilitate the upcoming expansion from 12 to 16 klystrons. The longer range goals to generalize the designs in such a way that they will be of benefit to other programs within the international fusion effort was met by designing a system which was flexible enough to address all the MIT system requirements, and modular enough to adapt to a large variety of other requirements with minimal reconfiguration.

  5. Non-statistical decay and $\\alpha$-correlations in the $^{12}$C+$^{12}$C fusion-evaporation reaction at 95 MeV

    CERN Document Server

    Morelli, L; D'Agostino, M; Gulminelli, F; Bruno, M; Abbondanno, U; Appannababu, S; Barlini, S; Bini, M; Casini, G; Cinausero, M; Degerlier, M; Fabris, D; Gelli, N; Gramegna, F; Kravchuk, V L; Marchi, T; Pasquali, G; Piantelli, S; Valdré, S; Raduta, Ad R

    2014-01-01

    Multiple alpha coincidence and correlations are studied in the reaction $^{12}$C+$^{12}$C at 95 MeV for fusion-evaporation events completely detected in charge. Two specific channels with Carbon and Oxygen residues in coincidence with $\\alpha$-particles are addressed, which are associated with anomalously high branching ratios with respect the predictions by Hauser-Feshbach calculations. Triple alpha emission appears kinematically compatible with a sequential emission from a highly excited Mg. The phase space distribution of $\\alpha$-$\\alpha$ coincidences suggests a correlated emission from a Mg compound, leaving an Oxygen residue excited above the threshold for neutron decay. These observations indicate a preferential $\\alpha$ emission of $^{24}$Mg at excitation energies well above the threshold for $6-\\alpha$ decay.

  6. Distributed Information Fusion through Advanced Multi-Agent Control

    Science.gov (United States)

    2016-09-09

    AFRL-AFOSR-JP-TR-2016-0080 Distributed Information Fusion through Advanced Multi-Agent Control Adrian Bishop NATIONAL ICT AUSTRALIA LIMITED Final...a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ORGANIZATION. 1. REPORT DATE (DD-MM-YYYY)      17-10-2016 2. REPORT... Control 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA2386-14-1-4042 5c.  PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S) Adrian Bishop 5d.  PROJECT NUMBER 5e

  7. Anomalous loss of DT alpha particles in the Tokamak Fusion Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Herrmann, Hans W. [Princeton Univ., NJ (United States)

    1997-09-01

    An escaping alpha collector probe has been developed for TFTR`s DT phase. Energy distributions of escaping alphas have been determined by measuring the range of α-particles implanted into nickel foils located within the alpha collector. Results at 1.0 MA of plasma current are in good agreement with predictions for first orbit alpha loss. Results at 1.8 MA, however, show a significant anomalous loss of partially thermalized alphas (in addition to the expected first orbit loss), which is not observed with the lost alpha scintillator detectors in DT plasmas, but does resemble the anomalous delayed loss seen in DD plasmas. None of the candidate explanations proposed thus far are fully consistent with the anomalous loss observations. An experiment designed to study the effect of plasma major radius shifts on α-particle loss has led to a better understanding of α-particle dynamics in tokamaks. Intuitively, one might suppose that confined marginally passing α-particles forced to move toward higher magnetic field during an inward major radius shift (i.e., compression) would mirror and become trapped particles, leading to increased alpha loss. Such an effect was looked for during the shift experiment, however, no significant changes in alpha loss to the 90° lost alpha scintillator detector were observed during the shifts. It is calculated that the energy gained by an α-particle during the inward shift is sufficient to explain this result. However, an unexpected loss of partially thermalized α-particles near the passing/trapped boundary was observed to occur between inward and outward shifts at an intermediate value of plasma current (1.4 MA). This anomalous loss feature is not yet understood.

  8. Suppression of the chain nuclear fusion reaction based on the p+{sup 11}B reaction because of the deceleration of alpha particles

    Energy Technology Data Exchange (ETDEWEB)

    Shmatov, M. L., E-mail: M.Shmatov@mail.ioffe.ru [Ioffe Institute (Russian Federation)

    2016-09-15

    It is shown that a rapid deceleration of alpha particles in matter of electron temperature up to 100 keV leads a strong suppression of the chain nuclear fusion reaction on the basis of the p+{sup 11}B reaction with the reproduction of fast protons in the α+{sup 11}B and n+{sup 10}B reactions. The statement that the chain nuclear fusion reaction based on the p+{sup 11}B reaction with an acceleration of {sup 11}B nuclei because of elastic alpha-particle scattering manifests itself in experiments at the PALS (Prague Asterix Laser System) facility is analyzed.

  9. Core fusion power gain and alpha heating in JET, TFTR, and ITER

    Science.gov (United States)

    Budny, R. V.; Cordey, J. G.; TFTR Team; Contributors, JET

    2016-05-01

    Profiles of the ratio of fusion power and the auxiliary heating power q DT are calculated for the TFTR and JET discharges with the highest neutron emission rates, and are predicted for ITER. Core values above 1.3 for JET and 0.8 for TFTR are obtained. Values above 20 are predicted for ITER baseline plasmas.

  10. Alpha-latrotoxin Triggers Extracellular Ca2+-dependent Exocytosis and Sensitizes Fusion Machinery in Endocrine Cells

    Institute of Scientific and Technical Information of China (English)

    Zhi-Tao HU; Ping ZHAO; Jie LIU; Zheng-Xing WU; Tao XU

    2006-01-01

    α-Latrotoxin from the venom of black widow spider induces and augments neurotransmitter and hormone release by way of extracellular Ca2+ influx and cellular signal transduction pathways. By using whole cell current and capacitance recording, the photolysis of caged Ca2+, and Ca2+ microfluorometry and amperometry, we investigated the stimulating effect and mechanism of o-latrotoxin on exocytosis in rat pancreatic β cells, LβT2 cells and latrophilin plasmid-transfected INS-1 cells. Our data indicated that: (1) α-latrotoxin increased cytosolic Ca2+ concentration through the formation of cation-permitting pores and subsequent Ca2+ influx with the presence of extracellular Ca2+; (2) α-latrotoxin stimulated exocytosis in normal bath solution and its stimulating effect on secretion was eradicated in Ca2+-free bath solution; and (3) α-latrotoxin sensitized the molecular machinery of fusion through activation of protein kinase C and increased the response of cells to Ca2+ photolysed by a flash of ultraviolet light. In summary, α-latrotoxin induced exocytosis by way of Ca2+ influx and accelerated vesicle fusion by the sensitization of fusion machinery.

  11. Development of thin foil Faraday collector as a lost alpha particle diagnostic for high yield D-T tokamak fusion plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Van Belle, P.; Jarvis, O.N.; Sadler, G.J. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Cecil, F.E. [Colorado School of Mines, Golden, CO (United States)

    1994-07-01

    Alpha particle confinement is necessary for ignition of a D-T tokamak fusion plasma and for first wall protection. Due to high radiation backgrounds and temperatures, scintillators and semiconductor detectors may not be used to study alpha particles which are lost to the first wall during the D-T programs on JET and ITER. An alternative method of charged particle spectrometry capable of operation in these harsh environments, is proposed: it consists of thin foils of electrically isolated conductors with the flux of alpha particles determined by the positive current flowing from the foils. 2 refs., 3 figs.

  12. An attempt to control a manmade nuclear fusion

    CERN Document Server

    Kornyushin, Yuri

    2007-01-01

    A detailed simple model is applied to study a high temperature hydrogen plasma ball. It is assumed that the ions and delocalized electrons are distributed randomly throughout the charged plasma ball (extra/missing charge is assumed to be found in a thin layer on the surface of a ball). The energy of the microscopic electrostatic field around the ions is taken into account and calculated. It is shown in the framework of the model that charged hydrogen plasma ball can be stable as a metastable state, when subjected to external (atmospheric) pressure. Equilibrium radius of a ball, the barrier and the enthalpy of the equilibrium ball are calculated. It looks like the charged plasma ball in a metastable equilibrium should be used to conduct controllable nuclear fusion. Changes in the electric charge can be used to control the volume of a plasma ball.

  13. BOOK REVIEW: Fundamentals of Plasma Physics and Controlled Fusion

    Science.gov (United States)

    Brambilla, Marco

    1998-04-01

    Professor Kenro Miyamoto, already well known for his textbook Plasma Physics for Nuclear Fusion (MIT Press, Cambridge, MA, 1976; revised edition 1989), has now published a new book entitled Fundamentals of Plasma Physics and Controlled Fusion (Iwanami Book Service Center, Tokyo, 1997). To a large extent, the new book is a somewhat shortened and well reorganized version of its predecessor. The style, concise and matter of fact, clearly shows the origin of the text in lectures given by the author to graduate students. As announced by the title, the book is divided into two parts: the first part (about 250 pages) is a general introduction to the physics of plasmas, while the second, somewhat shorter, part (about 150 pages), is devoted to a description of the most important experimental approaches to achieving controlled thermonuclear fusion. Even in the first part, moreover, the choice of subjects is consistently oriented towards the needs of fusion research. Thus, the introduction to the behaviour of charged particles (particle motion, collisions, etc.) and to the collective description of plasmas is quite short, although the reader will get a flavour of all the most important topics and will find a number of examples chosen for their relevance to fusion applications (only the presentation of the Vlasov equation, in the second section of Chapter 4, might be criticized as so concise as to be almost misleading, since the difference between microscopic and macroscopic fields is not even mentioned). Considerably more space is devoted to the magnetohydrodynamic (MHD) description of equilibrium and stability. This part includes the solution of the Grad-Shafranov equation for circular tokamaks, a brief discussion of Pfirsch-Schlüter, neoclassical and anomalous diffusion, and two relatively long chapters on the most important ideal and resistive MHD instabilities of toroidal plasmas; drift and ion temperature gradient driven instabilities are also briefly presented. The

  14. Burn Control of Magnetically Confined Fusion Plasma 2. Burn Control in Tokamak Fusion Reactors 2.3 Burn Control in ITER

    Science.gov (United States)

    Fujisawa, Noboru

    The issue of burn control in FDR-ITER, the design of which was completed in 1998, is introduced, Controllability was studied based on the ID transport code, PRETOR, during the burn phase with self-ignition, as well as during start-up and shut-down. The results of the present study have helped us to identify the importance of controlling the fuel supply, impurity injection, and heating power to maintain fusion power and power to the divertor.

  15. Burn control of an ITER-like fusion reactor using fuzzy logic

    Science.gov (United States)

    Garcia-Amador, A. Sair; Martinell, Julio J.

    2016-10-01

    The fuel burn in a fusion reactor has to be kept at a nearly constant rate in order to have a steady power exhaust. Here, we develop a control system based on a fuzzy logic controller in order that adjusts external parameters to keep the plasma temperature and density at the design values of a reactor of the characteristics of ITER. The control parameters chosen are the D-T refueling rate, the auxiliary heating power and a neutral helium beam. We use a fuzzy controller of the Mamdani type that uses a number of membership functions appropriate to produce a response to parameter deviations that minimizes the response time. The inference rules are determined in a way to provide stabilization to all perturbations of the temperature, density and alpha particle fraction. The dynamical response of the reactor is simulated with a 0D model that uses confinement times provided by the ITER scaling. We show that the system is feedback stabilized for a large range of parameters around the nominal values. The recovery time after a departure from the steady values is of the order of one second. We compare the results with another control system based on neural networks that was developed previously. Funded by projects PAPIIT IN109115 and Conacyt 152905.

  16. Fusion alpha-particle diagnostics for DT experiments on the joint European torus

    Energy Technology Data Exchange (ETDEWEB)

    Kiptily, V. G.; Beaumont, P.; Syme, D. B. [Euratom / CCFE Fusion Association, Culham Science Centre, Abingdon, Oxon (United Kingdom); Belli, F. [Associazione Euratom -ENEA sulla Fusione, C.R. Frascati, C.P. 65, Frascati (Italy); Cecil, F. E.; Riva, M. [Colorado School of Mines, Golden, CO (United States); Conroy, S.; Ericsson, G. [Department of Physics and Astronomy, Uppsala University, BOX 516, Uppsala (Sweden); Craciunescu, T. [Association Euratom -MEdC, National Institute for Laser, Plasma and Radiation Physics (Romania); Garcia-Munoz, M. [Max-Planck-Institut für Plasmaphysik, EURATOM-Association IPP, Garching, D-85748 (Germany); Curuia, M.; Soare, S. [Association Euratom -MEdC, National Institute for Cryogenics and Isotopic Technology (Romania); Darrow, D. [Princeton Plasma Physics Lab, Princeton, NJ (United States); Fernandes, A. M.; Pereira, R. C.; Sousa, J. [Euratom/IST Fusion Association, Centro de Fusão Nuclear, 1049-001 Lisboa (Portugal); Giacomelli, L.; Voitsekhovitch, I. [CNISM, Dipartimento di Fisica, Universita Milano-Bicocca, Milano (Italy); Gorini,; Nocente, M. [CNISM, Dipartimento di Fisica, Universita Milano-Bicocca, Milano, Italy and Associazione Euratom -ENEA sulla Fusione, IFP Milano (Italy); and others

    2014-08-21

    JET equipped with ITER-like wall (a beryllium wall and a tungsten divertor) can provide auxiliary heating with power up to 35MW, producing a significant population of α-particles in DT operation. The direct measurements of alphas are very difficult and α-particle studies require a significant development of dedicated diagnostics. JET now has an excellent set of confined and lost fast particle diagnostics for measuring the α-particle source and its evolution in space and time, α-particle energy distribution, and α-particle losses. This paper describes how the above mentioned JET diagnostic systems could be used for α-particle measurements, and what options exist for keeping the essential α-particle diagnostics functioning well in the presence of intense DT neutron flux. Also, α-particle diagnostics for ITER are discussed.

  17. Surface display of monkey metallothionein {alpha} tandem repeats and EGFP fusion protein on Pseudomonas putida X4 for biosorption and detection of cadmium

    Energy Technology Data Exchange (ETDEWEB)

    He, Xiaochuan; Chen, Wenli; Huang, Qiaoyun [Huazhong Agricultural Univ., Wuhan (China). State Key Lab. of Agricultural Microbiology

    2012-09-15

    Monkey metallothionein {alpha} domain tandem repeats (4mMT{alpha}), which exhibit high cadmium affinity, have been displayed for the first time on the surface of a bacterium using ice nucleation protein N-domain (inaXN) protein from the Xanthomonas campestris pv (ACCC - 10049) as an anchoring motif. The shuttle vector pIME, which codes for INAXN-4mMT{alpha}-EGFP fusion, was constructed and used to target 4mMT{alpha} and EGFP on the surface of Pseudomonas putida X4 (CCTCC - 209319). The surface location of the INAXN-4mMT{alpha}-EGFP fusion was further verified by western blot analysis and immunofluorescence microscopy. The growth of X4 showed resistance to cadmium presence. The presence of surface-exposed 4mMT{alpha} on the engineered strains was four times higher than that of the wild-type X4. The Cd{sup 2+} accumulation by X4/pIME was not only four times greater than that of the original host bacterial cells but was also remarkably unaffected by the presence of Cu{sup 2+} and Zn{sup 2+}. Moreover, the surface-engineered strains could effectively bind Cd{sup 2+} under a wide range of pH levels, from 4 to 7. P. putida X4/pIME with surface-expressed 4mMT{alpha}-EGFP had twice the cadmium binding capacity as well as 1.4 times the fluorescence as the cytoplasmic 4mMTa-EGFP. These results suggest that P. putida X4 expressing 4mMT{alpha}-EGFP with the INAXN anchor motif on the surface would be a useful tool for the remediation and biodetection of environmental cadmium contaminants. (orig.)

  18. Information Fusion-Based Optimal Attitude Control for an Alterable Thrust Direction Unmanned Aerial Vehicle

    Directory of Open Access Journals (Sweden)

    Ziyang Zhen

    2013-01-01

    Full Text Available Attitude control is the inner-loop and the most important part of the automatic flight control system of an unmanned aerial vehicle (UAV. The information fusion-based optimal control method is applied in a UAV flight control system in this work. Firstly, a nonlinear model of alterable thrust direction UAV (ATD-UAV is established and linearized for controller design. The longitudinal controller and lateral controller are respectively designed based on information fusion-based optimal control, and then the information fusion flight control system is built up. Finally, the simulation of a nonlinear model described as ATD-UAV is carried out, the results of which show the superiority of the information fusion-based control strategy when compared to the single-loop design method. We also show that the ATD technique improves the anti-disturbance capacity of the UAV.

  19. Heavy-quark pair production in gluon fusion at next-to-next-to-leading O({alpha}{sup 4}{sub s}) order. One-loop squared contributions

    Energy Technology Data Exchange (ETDEWEB)

    Kniehl, B.A.; Merebashvili, Z. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Koerner, J.G. [Mainz Univ. (Germany). Inst. fuer Physik; Rogal, M. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2008-09-15

    We calculate the next-to-next-to-leading order O({alpha}{sup 4}{sub s}) one-loop squared corrections to the production of heavy quark pairs in the gluon-gluon fusion process. Together with the previously derived results on the q anti q production channel the results of this paper complete the calculation of the oneloop squared contributions of the next-to-next-to-leading order O({alpha}{sup 4}{sub s}) radiative QCD corrections to the hadroproduction of heavy flavours. Our results, with the full mass dependence retained, are presented in a closed and very compact form, in dimensional regularization. (orig.)

  20. Inertial Confinement Fusion alpha-heating signatures in prompt gamma-ray measurements at the National Ignition Facility

    Science.gov (United States)

    Church, Jennifer; Herrmann, Hans; Cerjan, Charlie; Sayre, Daniel; Carpenter, Arthur; Liebman, Judy; Stoeffl, Wolfgang; Kim, Yongho

    2015-11-01

    Prompt gamma-rays measured at the National Ignition Facility (NIF) with the Gamma-ray Reaction History detector (GRH) supply vital diagnostic information, such as the peak burn time, burn width, and total neutron yield, from prompt DT-fusion gamma-ray emission during high convergence implosion experiments. Additionally, the stagnated cold shell density distribution may be inferred from the time-integrated, calibrated 12C (n,n' γ) signal, thus providing estimates of remaining ablator carbon areal density. Furthermore, simulations suggest that alpha heating signatures might be accessible using more highly resolved temporal gamma-ray emission. Correlation of these signatures with time-dependent neutron emission will constrain the implosion dynamics immediately prior to thermonuclear burn. Measurement of these gamma-ray signatures will be discussed along with updates on our work toward inferred total DT yield and 12C areal density. This work performed under the auspices of the U.S. Dept. of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07-NA27344, LLNL-ABS-670282.

  1. Overproduction, purification and characterization of human interferon alpha2a-human serum albumin fusion protein produced in methilotropic yeast Pichia pastoris

    Science.gov (United States)

    Ningrum, R. A.; Santoso, A.; Herawati, N.

    2017-05-01

    Human interferon alpha2a (hIFNα2a) is a therapeutic protein that used in cancer and hepatitis B/C therapy. The main problem of using hIFNα-2a is its short elimination half life due to its low molecular weight. Development of higher molecular weight protein by albumin fusion technology is a rational strategy to solve the problem. In our previous research we constructed an open reading frame (ORF) encoding hIFNα2a-human serum albumin (HSA) fusion protein that expressed in Pichia pastoris (P. pastoris) protease deficient strain SMD1168. This research was performed to overproduce, purify and characterize the fusion protein. To overproduce the protein, cultivation was performed in buffered complex medium containing glyserol (BMGY) for 24 h and protein overproduction was applied in buffered complex medium containing methanol (BMMY) for 48 hours at 30°C. The fusion protein was purified by blue sepharose affinity chromatography. Molecular weight characterization by SDS PAGE corresponds with its theoretical size, 85 kDa. Western blot analysis demonstrated that the fusion protein was recognized by anti hIFNα2 and anti HSA monoclonal antibody as well. Amino acid sequence of the fusion protein was determined by LC MS/MS2 mass spectrometry with trypsin as proteolitic enzyme. There were three fragments that identified as hIFNα2a and seven fragments that identified as HSA. Total identified amino acids were 150 residues with 20% coverage from total residues. To conclude, hIFNα2a-HSA fusion protein was overproduced, purified and characterized. Characterization based on molecular weight, antibody recognition and amino acid sequence confirmed that the fusion protein has correct identity as theoretically thought.

  2. Particle-in-cell simulations of an alpha channeling scenario: electron current drive arising from lower hybrid drift instability of fusion-born ions

    Science.gov (United States)

    Cook, James; Chapman, Sandra; Dendy, Richard

    2010-11-01

    Particle-in-cell (PIC) simulations of fusion-born protons in deuterium plasmas demonstrate a key alpha channeling phenomenon for tokamak fusion plasmas. We focus on obliquely propagating modes at the plasma edge, excited by centrally born fusion products on banana orbits, known to be responsible for observations of ion cyclotron emission in JET and TFTR. A fully self-consistent electromagnetic 1D3V PIC code evolves a ring-beam distribution of 3MeV protons in a 10keV thermal deuterium-electron plasma with realistic mass ratio. A collective instability occurs, giving rise to electromagnetic field activity in the lower hybrid range of frequencies. Waves spontaneously excited by this lower hybrid drift instability undergo Landau damping on resonant electrons, drawing out an asymmetric tail in the distribution of electron parallel velocities, which constitutes a net current. These simulations demonstrate a key building block of some alpha channeling scenarios: the direct collisionless coupling of fusion product energy into a form which can help sustain the equilibrium of the tokamak.

  3. A Genetic System Controlling Mitochondrial Fusion in the Slime Mould, Physarum Polycephalum

    Science.gov (United States)

    Kawano, S.; Takano, H.; Imai, J.; Mori, K.; Kuroiwa, T.

    1993-01-01

    We have identified two distinct mitochondrial phenotypes, namely, Mif(+) (mitochondrial fusion) and Mif(-) (mitochondrial fusion-deficient), and have studied the genetic system that controls mitochondrial fusion in the slime mould, Physarum polycephalum. A mitochondrial plasmid of approximately 16 kbp was identified in all Mif(+) plasmodial strains. This plasmid is apparently responsible for promoting mitochondrial fusion, and it is inserted into the mitochondrial DNA (mtDNA) in successive sexual crossing with Mif(-) strains. This recombinant mtDNA and the unchanged free plasmid spread through the mitochondrial population via the promotion of mitochondrial fusion. The Mif(+) strains with the plasmid were further classified as being two types: high frequency and low frequency mitochondrial fusion. Restriction analysis of the mtDNA suggested that the high frequency mitochondrial fusion type was more often heteroplasmic; within each plasmodium, mtDNAs of both parental types were usually present, in addition to the presence of the plasmid. Genetic analysis with the progeny obtained from crossing myxamoebae derived from three different isolates suggested that these progeny carried different alleles at a nuclear locus that controlled the frequency of mitochondrial fusion. These alleles (mitochondrial mating-type alleles, mitA1, 2 and 3) appear to function like the mating type of the myxamoebae; mitochondrial fusion occurs at high frequency with the combination of unlike alleles, but at low frequency with the combination of like alleles. PMID:8436271

  4. Controlled Nuclear Fusion by Magnetic Confinement and ITER

    CERN Document Server

    CERN. Geneva. Audiovisual Unit; Alvarez-Gaumé, Luís

    2005-01-01

    For may years harnessing fusion energy was considered the final solution to the world's energy crisis. ITER is the last step in the elusive quest. This presentation will provide in its various acientific, technological and political aspects.

  5. SENSOR FUSION CONTROL SYSTEM FOR COMPUTER INTEGRATED MANUFACTURING

    Directory of Open Access Journals (Sweden)

    C.M. Kumile

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Manufacturing companies of today face unpredictable, high frequency market changes driven by global competition. To stay competitive, these companies must have the characteristics of cost-effective rapid response to the market needs. As an engineering discipline, mechatronics strives to integrate mechanical, electronic, and computer systems optimally in order to create high precision products and manufacturing processes. This paper presents a methodology of increasing flexibility and reusability of a generic computer integrated manufacturing (CIM cell-control system using simulation and modelling of mechatronic sensory system (MSS concepts. The utilisation of sensors within the CIM cell is highlighted specifically for data acquisition, analysis, and multi-sensor data fusion. Thus the designed reference architecture provides comprehensive insight for the functions and methodologies of a generic shop-floor control system (SFCS, which consequently enables the rapid deployment of a flexible system.

    AFRIKAANSE OPSOMMING: Hedendaagse vervaardigingsondernemings ervaar gereeld onvoorspelbare markveranderinge wat aangedryf word deur wêreldwye mededinging. Om kompeterend te bly moet hierdie ondernemings die eienskappe van kosteeffektiwiteit en snelle-respons op markfluktuasies toon. Megatronika streef daarna om meganiese, elektroniese en rekenaarstelsels optimaal te integreer om hoëpresisieprodukte en produksieprosesse daar te stel. Hierdie artikel suggereer 'n metodologie vir toenemende aanpasbaarheid en herbruikbaarheid van 'n generiese rekenaargeïntegreerde vervaardigingsel-beheersisteem deur die gebruik van simulasie en die modellering van megatroniese sensorsisteemkonsepte. Die aanwending van sensors binne die sel fasiliteer datavaslegging, ontleding en multisensordatafusie. Sodoende verskaf die ontwerpte argitektuur insig in die funksie en metodologie van 'n generiese stukwerkwinkelbeheersisteem wat die vinnige

  6. Myxoma virus expressing a fusion protein of interleukin-15 (IL15 and IL15 receptor alpha has enhanced antitumor activity.

    Directory of Open Access Journals (Sweden)

    Vesna Tosic

    Full Text Available Myxoma virus, a rabbit poxvirus, can efficiently infect various types of mouse and human cancer cells. It is a strict rabbit-specific pathogen, and is thought to be safe as a therapeutic agent in all non-rabbit hosts tested including mice and humans. Interleukin-15 (IL15 is an immuno-modulatory cytokine with significant potential for stimulating anti-tumor T lymphocytes and NK cells. Co-expression of IL15 with the α subunit of IL15 receptor (IL15Rα greatly enhances IL15 stability and bioavailability. Therefore, we engineered a new recombinant myxoma virus (vMyx-IL15Rα-tdTr, which expresses an IL15Rα-IL15 fusion protein plus tdTomato red fluorescent reporter protein. Permissive rabbit kidney epithelial (RK-13 cells infected with vMyx-IL15Rα-tdTr expressed and secreted the IL15Rα-IL15 fusion protein. Functional activity was confirmed by demonstrating that the secreted fusion protein stimulated proliferation of cytokine-dependent CTLL-2 cells. Multi-step growth curves showed that murine melanoma (B16-F10 and B16.SIY cell lines were permissive to vMyx-IL15Rα-tdTr infection. In vivo experiments in RAG1-/- mice showed that subcutaneous B16-F10 tumors treated with vMyx-IL15Rα-tdTr exhibited attenuated tumor growth and a significant survival benefit for the treated group compared to the PBS control and the control viruses (vMyx-IL15-tdTr and vMyx-tdTr. Immunohistological analysis of the subcutaneous tumors showed dramatically increased infiltration of NK cells in vMyx-IL15Rα-tdTr treated tumors compared to the controls. In vivo experiments with immunocompetent C57BL/6 mice revealed a strong infiltrate of both NK cells and CD8+ T cells in response to vMyx-IL15Rα-tdTr, and prolonged survival. We conclude that delivery of IL15Rα-IL15 in a myxoma virus vector stimulates both innate and adaptive components of the immune system.

  7. PLZF-RAR[alpha] fusion proteins generated from the variant t(11; 17)(q23; q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Zhu; Chen, Sai-Juan; Wang, Zhen-Yi (Shanghai Second Medical Univ. (China)); Guidez, F.; Rousselot, P.; Agadir, A.; Degos, L.; Chomienne, C. (Laboratoire de Biologie Cellulaire Hematopoietique, Paris (France)); Zelent, A. (Institute for Cancer Research, London (United Kingdom)); Waxman, S. (Mount Sinai Medical Center, New York, NY (United States))

    1994-02-01

    Recently, the authors described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor [alpha] (RAR[alpha]). They have now cloned cDNAs encoding PLZF-RAR[alpha] chimeric proteins and studied their transactivating activities. In transient-expression assays, both the PLZF(A)-RAR[alpha] and PLZF(B)-RAR[alpha] fusion proteins like the PML-RAR[alpha] protein resulting from the well-known t(15;17) translocation in APL, antagonized endogenous and transfected wild-type RAR[alpha] in the presence of retinoic acid. Cotransfection assays showed that a significant repression of RAR[alpha] transactivation activity was obtained even with a very low PLZF-RAR[alpha]-expressing plasmid concentration. A [open quotes]dominant negative[close quotes] effect was observed with vectors expressing RAR[alpha] and retinoid X receptor [alpha] (RXR[alpha]). These abnormal transactivation properties observed in retinoic acid-sensitive myeloid cells strongly implicate the PLZF-RAR[alpha] fusion proteins in the molecular pathogenesis of APL.

  8. Circumferential fusion is dominant over posterolateral fusion in a long-term perspective: cost-utility evaluation of a randomized controlled trial in severe, chronic low back pain

    DEFF Research Database (Denmark)

    Soegaard, Rikke; Bünger, Cody E; Christiansen, Terkel

    2007-01-01

    STUDY DESIGN: Cost-utility evaluation of a randomized, controlled trial with a 4- to 8-year follow-up. OBJECTIVE: To investigate the incremental cost per quality-adjusted-life-year (QALY) when comparing circumferential fusion to posterolateral fusion in a long-term, societal perspective. SUMMARY ...

  9. Design of a Fast Neutral He Beam System for Feasibility Study of Charge-Exchange Alpha-Particle Diagnostics in a Thermonuclear Fusion Reactor

    CERN Document Server

    Shinto, Katsuhiro; Kitajima, Sumio; Kiyama, Satoru; Nishiura, Masaki; Sasao, Mamiko; Sugawara, Hiroshi; Takenaga, Mahoko; Takeuchi, Shu; Wada, Motoi

    2005-01-01

    For alpha-particle diagnostics in a thermonuclear fusion reactor, neutralization using a fast (~2 MeV) neutral He beam produced by the spontaneous electron detachment of a He- is considered most promising. However, the beam transport of produced fast neutral He has not been studied, because of difficulty for producing high-brightness He- beam. Double-charge-exchange He- sources and simple beam transport systems were developed and their results were reported in the PAC99* and other papers.** To accelerate an intense He- beam and verify the production of the fast neutral He beam, a new test stand has been designed. It consists of a multi-cusp He+

  10. Stromal Cell-Derived Growth Factor-1 Alpha-Elastin Like Peptide Fusion Protein Promotes Cell Migration and Revascularization of Experimental Wounds in Diabetic Mice

    Science.gov (United States)

    Yeboah, Agnes; Maguire, Tim; Schloss, Rene; Berthiaume, Francois; Yarmush, Martin L.

    2017-01-01

    Objective: In previous work, we demonstrated the development of a novel fusion protein containing stromal cell-derived growth factor-1 alpha juxtaposed to an elastin-like peptide (SDF1-ELP), which has similar bioactivity, but is more stable in elastase than SDF1. Herein, we compare the ability of a single topical application of SDF1-ELP to that of SDF1 in healing 1 × 1 cm excisional wounds in diabetic mice. Approach: Human Leukemia-60 cells were used to demonstrate the chemotactic potential of SDF1-ELP versus SDF1 in vitro. Human umbilical vascular endothelial cells were used to demonstrate the angiogenic potential of SDF1-ELP versus SDF1 in vitro. The bioactivity of SDF1-ELP versus SDF1 after incubation in ex-vivo diabetic wound fluid was compared. The in-vivo effectiveness of SDF1-ELP versus SDF1 was compared in diabetic mice wound model by monitoring for the number of CD31+ cells in harvested wound tissues. Results: SDF1-ELP promotes the migration of cells and induces vascularization similar to SDF1 in vitro. SDF1-ELP is more stable in wound fluids compared to SDF1. In vivo, SDF1-ELP induced a higher number of vascular endothelial cells (CD31+ cells) compared to SDF1 and other controls, suggesting increased vascularization. Innovation: While growth factors have been shown to improve wound healing, this strategy is largely ineffective in chronic wounds. In this work, we show that SDF1-ELP is a promising agent for the treatment of chronic skin wounds. Conclusion: The superior in vivo performance and stability of SDF1-ELP makes it a promising agent for the treatment of chronic skin wounds. PMID:28116224

  11. Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12.

    Science.gov (United States)

    Rhee, Inmoo; Davidson, Dominique; Souza, Cleiton Martins; Vacher, Jean; Veillette, André

    2013-06-01

    Macrophages can undergo cell-cell fusion, leading to the formation of multinucleated giant cells and osteoclasts. This process is believed to promote the proteolytic activity of macrophages toward pathogens, foreign bodies, and extracellular matrices. Here, we examined the role of PTP-PEST (PTPN12), a cytoplasmic protein tyrosine phosphatase, in macrophage fusion. Using a macrophage-targeted PTP-PEST-deficient mouse, we determined that PTP-PEST was not needed for macrophage differentiation or cytokine production. However, it was necessary for interleukin-4-induced macrophage fusion into multinucleated giant cells in vitro. It was also needed for macrophage fusion following implantation of a foreign body in vivo. Moreover, in the RAW264.7 macrophage cell line, PTP-PEST was required for receptor activator of nuclear factor kappa-B ligand (RANKL)-triggered macrophage fusion into osteoclasts. PTP-PEST had no impact on expression of fusion mediators such as β-integrins, E-cadherin, and CD47, which enable macrophages to become fusion competent. However, it was needed for polarization of macrophages, migration induced by the chemokine CC chemokine ligand 2 (CCL2), and integrin-induced spreading, three key events in the fusion process. PTP-PEST deficiency resulted in specific hyperphosphorylation of the protein tyrosine kinase Pyk2 and the adaptor paxillin. Moreover, a fusion defect was induced upon treatment of normal macrophages with a Pyk2 inhibitor. Together, these data argue that macrophage fusion is critically dependent on PTP-PEST. This function is seemingly due to the ability of PTP-PEST to control phosphorylation of Pyk2 and paxillin, thereby regulating cell polarization, migration, and spreading.

  12. Controlled Fusion with Hot-ion Mode in a Degenerate Plasma

    Energy Technology Data Exchange (ETDEWEB)

    S. Son and N.J. Fisch

    2005-12-01

    n a Fermi-degenerate plasma, the rate of electron physical processes is much reduced from the classical prediction, possibly enabling new regimes for controlled nuclear fusion, including the hot-ion mode, a regime in which the ion temperature exceeds the electron temperature. Previous calculations of these processes in dense plasmas are now corrected for partial degeneracy and relativistic effects, leading to an expanded regime of self-sustained fusion.

  13. Research programme on controlled thermonuclear fusion. Synthesis report 2011; Programme de recherche Fusion thermonucleaire controlee. Rapport de synthese 2011

    Energy Technology Data Exchange (ETDEWEB)

    Vaucher, C. [Secretariat d' Etat a l' education et a la recherche, Berne (Switzerland); Tran, M. Q.; Villard, L. [Swiss Federal Institute of Technology (EPFL), Lausanne (Switzerland); Marot, L. [University of Basel, Basel (Switzerland)

    2012-07-01

    Since 1978, research on thermonuclear fusion in Switzerland is closely related to the research programme of the European Atomic Energy Community (EURATOM). The Swiss projects tackle aspects of plasma physics and fusion technology. Switzerland participates to the construction and operation of the Joint European Torus (JET), which started operation again in 2011. The International Thermonuclear Experimental Reactor (ITER) is the last step before DEMO, a prototype fusion reactor able to deliver electricity and demonstrate the economic viability of fusion energy. The 'Centre de Recherches en Physique des Plasmas' (CRPP) of the EPFL went on with its participation to the scientific and technological programme of EURATOM. Researches are carried out essentially on 2 sites: (i) at EPFL, where topics dealt with include the physics of magnetic confinement studied using the Variable Configuration Tokamak (TCV), the basic experiment TORPEX, theory and numerical modelling, and the technology of plasma heating and current generation by hyper-frequency waves; (ii) at the Paul Scherrer Institute (PSI), where activities are devoted to superconductivity and structure materials. Thanks to the large flexibility of the TCV design and operation modus, plasmas of different shapes can be created and controlled, what is a very useful option to verify numerical simulation results. Besides, the injection of millimetre waves allows directing the injected power according to specific profiles. In the TCV it could be demonstrated for the first time that the injection of Electronic Cyclotronic Heating (ECH) waves is able to double the frequency of so-called 'Edge Localized Modes' (ELM), reducing by a factor of 2 the energy expelled by each ELM. In particular, it was possible to considerably reduce the statistical dispersion of the repetition frequency of ELM, and to avoid the appearance of gigantic ELM that are particularly harmful for reactor operation. The effect of plasma

  14. Effect of tumor necrosis factor-alpha in rats with hepatic ischemia-reper fusion injur y

    Institute of Scientific and Technical Information of China (English)

    Mao Ma; Zhen-Hua Ma

    2008-01-01

    BACKGROUND:With the development of hepatic surgery, especially liver transplantation, the pathophysiological processes of hepatic ischemia-reperfusion (I/R) injury have gained special attention. Controlling I/R injury has become one of the most important factors for successful liver transplantation. This study aimed to investigate the effects of tumor necrosis factor-alpha (TNF-α) in rats with hepatic I/R injury and promote the recognition of I/R injury in the liver. METHODS:Thirty-two Sprague-Dawley rats were randomly divided into 2 groups. Rats in the sham-operated (SO) group served as controls. Rats in the hepatic ischemia-reperfusion (I/R) group underwent reperfusion after 30 minutes of liver ischemia. Rats were sacriifced at 1, 6 and 12 hours. The expression of TNF-αmRNA in the liver was measured by RT-PCR. Histological changes in the liver were assessed. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were measured. RESULTS:The expression of TNF-αmRNA in the SO group was decreased compared with that in the I/R group (P CONCLUSION:ALT and AST in serum are closely related to hepatic I/R injury and inlfammatory reaction. TNF-αproduction in the liver triggers hepatic I/R injury through a cascade.

  15. Formation of visual memories controlled by gamma power phase-locked to alpha oscillations

    Science.gov (United States)

    Park, Hyojin; Lee, Dong Soo; Kang, Eunjoo; Kang, Hyejin; Hahm, Jarang; Kim, June Sic; Chung, Chun Kee; Jiang, Haiteng; Gross, Joachim; Jensen, Ole

    2016-06-01

    Neuronal oscillations provide a window for understanding the brain dynamics that organize the flow of information from sensory to memory areas. While it has been suggested that gamma power reflects feedforward processing and alpha oscillations feedback control, it remains unknown how these oscillations dynamically interact. Magnetoencephalography (MEG) data was acquired from healthy subjects who were cued to either remember or not remember presented pictures. Our analysis revealed that in anticipation of a picture to be remembered, alpha power decreased while the cross-frequency coupling between gamma power and alpha phase increased. A measure of directionality between alpha phase and gamma power predicted individual ability to encode memory: stronger control of alpha phase over gamma power was associated with better memory. These findings demonstrate that encoding of visual information is reflected by a state determined by the interaction between alpha and gamma activity.

  16. Synergetic fMRI-EEG brain mapping in alpha-rhythm voluntary control mode.

    Science.gov (United States)

    Shtark, M B; Verevkin, E G; Kozlova, L I; Mazhirina, K G; Pokrovskii, M A; Petrovskii, E D; Savelov, A A; Starostin, A S; Yarosh, S V

    2015-03-01

    For the first time in neurobiology-related issues, the synergistic spatial dynamics of EEG and fMRI (BOLD phenomenon) was studied during cognitive alpha biofeedback training in the operant conditioning mode (acoustic reinforcement of alpha-rhythm development and stability). Significant changes in alpha-rhythm intensity were found in T6 electrode area (Brodmann area 37). Brodmann areas related to solving alpha-training tasks and maximally involved in the formation of new neuronal network were middle and superior temporal gyri (areas 21, 22, and 37), fusiform gyrus, inferior frontal gyrus (areas 4, 6, and 46), anterior cingulate gyrus (areas 23 and 24), cuneus, and precuneus (area 7). Wide involvement of Brodmann areas is determined by psychological architecture of alpha-rhythm generating system control that includes complex cognitive activities: decision making, retrieval of long-term memory, evaluation of the reward and control efficiency during alpha-EEG biofeedback.

  17. SPOT WELDING QUALITY FUZZY CONTROL SYSTEM BASED ON MULTISENSOR INFORMATION FUSION

    Institute of Scientific and Technical Information of China (English)

    CHANG Yunlong; SU Hang; LIN Bin; YANG Xu

    2007-01-01

    The multisensor information fusion technology is adopted for real time measuring the four Parameters which are connected closely with the weld nugget size(welding current, electrode displacement, dynamic resistance, welding time), thus much more original information is obtained. In this way, the difficulty caused by measuring indirectly weld nugget size can be decreased in spot welding quality control, and the stability of spot welding quality can be improved. According to this method, two-dimensional fuzzy Controllers are designed with the information fusion result as input and the thyristor control signal as output. The spot welding experimental results indicate that the spot welding quality intelligent control method based on multisensor information fusion technology can compensate the influence caused by variable factors in welding process and ensure the stability of welding quality.

  18. Reduction of mouse egg surface integrin alpha9 subunit (ITGA9) reduces the egg's ability to support sperm-egg binding and fusion.

    Science.gov (United States)

    Vjugina, Ulyana; Zhu, Xiaoling; Oh, Eugene; Bracero, Nabal J; Evans, Janice P

    2009-04-01

    The involvement of egg integrins in mammalian sperm-egg interactions has been controversial, with data from integrin inhibitor studies contrasting with evidence from knockouts showing that specific integrin subunits are not essential for fertility. An alpha(4)/alpha(9) (ITGA4/ITGA9) integrin subfamily member has been implicated in fertilization but not extensively examined, so we tested the following three hypotheses: 1) an ITGA4/ITGA9 integrin participates in sperm-egg interactions, 2) short-term acute knockdown by RNA interference of integrin subunits would result in a fertilization phenotype differing from that of chronic depletion via knockout, and 3) detection of a fertilization phenotype is sensitive to in vitro fertilization (IVF) assay conditions. We show that mouse and human eggs express the alpha(9) integrin subunit (ITGA9). RNA interference-mediated knockdown resulted in reduced levels of Itga9 mRNA and surface protein in mouse eggs. RNA interference attempts to knockdown ITGA9's likely beta partner, beta(1) (ITGB1), resulted in reduced Itgb1 mRNA but no reduction in ITGB1 surface protein. Therefore, studies using a function-blocking anti-ITGB1 antibody tested the hypothesis that ITGB1 participates in gamete interactions. Analyses of sperm-egg interactions with Itga9-knockdown eggs and anti-ITGB1 antibody-treated eggs in IVF assays using specific sperm:egg ratios revealed the following: 1) a reduction, but not complete loss, of sperm-egg binding and fusion was observed and 2) the reduction of sperm-egg binding and fusion was not detected in inseminations with high sperm:egg ratios. These data demonstrate that ITGA9 and ITGB1 participate in sperm-egg interactions but clearly are not the only molecules involved. This also shows that careful design of IVF parameters allows detection of deficiencies in gamete interactions.

  19. Control of fuel target implosion non-uniformity in heavy ion inertial fusion

    CERN Document Server

    Iinuma, T; Kondo, S; Kubo, T; Kato, H; Suzuki, T; Kawata, S; Ogoyski, A I

    2016-01-01

    In inertial fusion, one of scientific issues is to reduce an implosion non-uniformity of a spherical fuel target. The implosion non-uniformity is caused by several factors, including the driver beam illumination non-uniformity, the Rayleigh-Taylor instability (RTI) growth, etc. In this paper we propose a new control method to reduce the implosion non-uniformity; the oscillating implosion acceleration dg(t) is created by pulsating and dephasing heavy ion beams (HIBs) in heavy ion inertial fusion (HIF). The dg(t) would reduce the RTI growth effectively. The original concept of the non- uniformity control in inertial fusion was proposed in (Kawata, et al., 1993). In this paper it was found that the pulsating and dephasing HIBs illumination provide successfully the controlled dg(t) and that dg(t) induced by the pulsating HIBs reduces well the implosion non-uniformity. Consequently the pulsating HIBs improve a pellet gain remarkably in HIF.

  20. Lithium-based surfaces controlling fusion plasma behavior at the plasma-material interfacea)

    Science.gov (United States)

    Allain, Jean Paul; Taylor, Chase N.

    2012-05-01

    The plasma-material interface and its impact on the performance of magnetically confined thermonuclear fusion plasmas are considered to be one of the key scientific gaps in the realization of nuclear fusion power. At this interface, high particle and heat flux from the fusion plasma can limit the material's lifetime and reliability and therefore hinder operation of the fusion device. Lithium-based surfaces are now being used in major magnetic confinement fusion devices and have observed profound effects on plasma performance including enhanced confinement, suppression and control of edge localized modes (ELM), lower hydrogen recycling and impurity suppression. The critical spatial scale length of deuterium and helium particle interactions in lithium ranges between 5-100 nm depending on the incident particle energies at the edge and magnetic configuration. Lithium-based surfaces also range from liquid state to solid lithium coatings on a variety of substrates (e.g., graphite, stainless steel, refractory metal W/Mo/etc., or porous metal structures). Temperature-dependent effects from lithium-based surfaces as plasma facing components (PFC) include magnetohydrodynamic (MHD) instability issues related to liquid lithium, surface impurity, and deuterium retention issues, and anomalous physical sputtering increase at temperatures above lithium's melting point. The paper discusses the viability of lithium-based surfaces in future burning-plasma environments such as those found in ITER and DEMO-like fusion reactor devices.

  1. A systematic approach to the linear-stability assessment of Alfv\\'en eigenmodes in the presence of fusion-born alpha particles for ITER-like equilibria

    CERN Document Server

    Rodrigues, P; Ferreira, J; Coelho, R; Nabais, F; Borba, D; Loureiro, N F; Oliver, H J C; Sharapov, S E

    2014-01-01

    A systematic approach to assess the linear stability of Alfv\\'en eigenmodes in the presence of fusion-born alpha particles is described. Because experimental results for ITER are not available yet, it is not known beforehand which Alfv\\'en eigenmodes will interact more intensively with the alpha-particle population. Therefore, the number of modes that need to be considered in stability assessments becomes quite large and care must be exercised when choosing the numerical tools to work with, which must be fast and efficient. In the presented approach, all possible eigenmodes are first found after intensively scanning a suitable frequency range. Each solution found is then tested to find if its discretization over the radial grid in use is adequate. Finally, the interaction between the identified eigenmodes and the alpha-particle population is evaluated with the drift-kinetic code CASTOR-K, in order to assess their growth rates and hence their linear stability. The described approach enables one to single out t...

  2. High-Alpha Research Vehicle (HARV) longitudinal controller: Design, analyses, and simulation resultss

    Science.gov (United States)

    Ostroff, Aaron J.; Hoffler, Keith D.; Proffitt, Melissa S.; Brown, Philip W.; Phillips, Michael R.; Rivers, Robert A.; Messina, Michael D.; Carzoo, Susan W.; Bacon, Barton J.; Foster, John F.

    1994-01-01

    This paper describes the design, analysis, and nonlinear simulation results (batch and piloted) for a longitudinal controller which is scheduled to be flight-tested on the High-Alpha Research Vehicle (HARV). The HARV is an F-18 airplane modified for and equipped with multi-axis thrust vectoring. The paper includes a description of the facilities, a detailed review of the feedback controller design, linear analysis results of the feedback controller, a description of the feed-forward controller design, nonlinear batch simulation results, and piloted simulation results. Batch simulation results include maximum pitch stick agility responses, angle of attack alpha captures, and alpha regulation for full lateral stick rolls at several alpha's. Piloted simulation results include task descriptions for several types of maneuvers, task guidelines, the corresponding Cooper-Harper ratings from three test pilots, and some pilot comments. The ratings show that desirable criteria are achieved for almost all of the piloted simulation tasks.

  3. Research programme on controlled thermonuclear fusion - Synthesis report 2010; Programme de recherche Fusion thermonucleaire controlee. Rapport de synthese 2010

    Energy Technology Data Exchange (ETDEWEB)

    Vaucher, C. [Secretariat d' Etat a l' education et a la recherche, Berne (Switzerland); Tran, M. Q.; Villard, L. [Swiss Federal Institute of Technology (EPFL), Lausanne (Switzerland); Marot, L. [University of Basel, Basel (Switzerland)

    2011-07-01

    Since 1978, research on thermonuclear fusion in Switzerland is closely related to the research programme of the European Atomic Energy Community (EURATOM). The Swiss projects tackle aspects of plasma physics and fusion technology. Switzerland participates to the construction and operation of the Joint European Torus (JET). The International Thermonuclear Experimental Reactor (ITER) is being built; the first plasma is expected in 2019. The 'Centre de Recherches en Physique des Plasmas' (CRPP) of the EPFL participates to EURATOM scientific and technological projects in magnetic confinement physics, through an experimental contribution (the Variable Configuration Tokamak, TCV) and theoretical studies. Thanks to the large flexibility of the TCV design and operation modus, plasmas of different shapes can be created and controlled, what is a very useful option to verify numerical simulation results. Besides, the injection of millimetre waves allows directing the injected power according to specific profiles. A configuration of type 'snowflakes' could be created, reducing the power deposition at the edge of the plasma. Theoretical studies on turbulence have improved the plasma stability in the TCV. For the first time in the world, TCV could reach a stable plasma, the plasma current being generated using the so-called 'bootstrap' phenomenon. Besides turbulence, studies were focused on heat and particle transport in tokamaks, on an analysis of the equilibrium and magneto-hydrodynamic stability of tokamaks and stellarators, on the application of radiofrequency waves and on the optimization of new confinement configurations. Experiments in the JET facility confirmed the numerical results of theoretical simulations. The TORPEX facility, which is simpler than TCV, allows high space-temporal resolution measurements for the study of turbulences and plasma threads ('blobs'). At the Paul Scherrer Institute (PSI), research topics include

  4. Contributed papers presented at the 24. EPS conference on controlled fusion and plasma physics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    In the report thirteen papers are compiled which were presented by members of the Centre de Recherches en Physique des Plasma, Lausanne, at the 24th EPS conference on controlled fusion and plasma physics. They mainly deal with problems of the confinement and are based on studies performed in the TCV tokamak. figs., tabs., refs.

  5. Anomaly Detection for Resilient Control Systems Using Fuzzy-Neural Data Fusion Engine

    Energy Technology Data Exchange (ETDEWEB)

    Ondrej Linda; Milos Manic; Timothy R. McJunkin

    2011-08-01

    Resilient control systems in critical infrastructures require increased cyber-security and state-awareness. One of the necessary conditions for achieving the desired high level of resiliency is timely reporting and understanding of the status and behavioral trends of the control system. This paper describes the design and development of a neural-network based data-fusion system for increased state-awareness of resilient control systems. The proposed system consists of a dedicated data-fusion engine for each component of the control system. Each data-fusion engine implements three-layered alarm system consisting of: (1) conventional threshold-based alarms, (2) anomalous behavior detector using self-organizing maps, and (3) prediction error based alarms using neural network based signal forecasting. The proposed system was integrated with a model of the Idaho National Laboratory Hytest facility, which is a testing facility for hybrid energy systems. Experimental results demonstrate that the implemented data fusion system provides timely plant performance monitoring and cyber-state reporting.

  6. Anomaly Detection for Resilient Control Systems Using Fuzzy-Neural Data Fusion Engine

    Energy Technology Data Exchange (ETDEWEB)

    Ondrej Linda; Milos Manic; Timothy R. McJunkin

    2011-08-01

    Resilient control systems in critical infrastructures require increased cyber-security and state-awareness. One of the necessary conditions for achieving the desired high level of resiliency is timely reporting and understanding of the status and behavioral trends of the control system. This paper describes the design and development of a neural-network based data-fusion system for increased state-awareness of resilient control systems. The proposed system consists of a dedicated data-fusion engine for each component of the control system. Each data-fusion engine implements three-layered alarm system consisting of: (1) conventional threshold-based alarms, (2) anomalous behavior detector using self-organizing maps, and (3) prediction error based alarms using neural network based signal forecasting. The proposed system was integrated with a model of the Idaho National Laboratory Hytest facility, which is a testing facility for hybrid energy systems. Experimental results demonstrate that the implemented data fusion system provides timely plant performance monitoring and cyber-state reporting.

  7. O-16 Coulomb dissociation : towards a new means to determine the C-12+alpha fusion rate in stars

    NARCIS (Netherlands)

    Fleurot, F; van den Berg, AM; Davids, B; Harakeh, MN; Kravchuk, VL; Wilschut, HW; Guillot, J; Laurent, H; Willis, A; Assuncao, M; Kiener, J; Lefebvre, A; de Sereville, N; Tatischeff, [No Value; Assuncao, L.; Lefebvre, L.; Tafischeff, V.

    2005-01-01

    A feasibility study was made of an important aspect of the Coulomb-dissociation method, which has been proposed for the determination of the rate of the astrophysically important C-12(alpha, gamma)160 reaction. A crucial aspect is the disentanglement of nuclear and Coulomb interactions on one hand a

  8. Large distributed control system using Ada in fusion research

    Energy Technology Data Exchange (ETDEWEB)

    Van Arsdall, P J; Woodruff, J P

    1998-08-11

    Construction of the National Ignition Facility laser at Lawrence Livermore National Laboratory features a distributed control system that uses object-oriented software engineering techniques. Control of 60,000 devices is effected using a network of some 500 computers. The software is being written in Ada and communicates through CORBA. Software controls are implemented in two layers: individual device controllers and a supervisory layer. The software architecture provides services in the form of frameworks that address issues common to event-driven control systems. Those services are allocated to levels that strictly prescribe their interdependency so the levels are separately reusable. The project has completed its final design review. The delivery of the first increment takes place in October 1998. Keywords Distributed control system, object-oriented development, CORBA, application frameworks, levels of abstraction

  9. Expert system to control a fusion energy experiment

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R.R.; Canales, T.; Lager, D.

    1986-01-01

    This paper describes a system that automates neutral beam source conditioning. The system achieves this with artificial intelligence techniques by encoding the behavior of several experts as a set of if-then rules in an expert system. One of the functions of the expert system is to control an adaptive controller that, in turn, controls the neutral beam source. The architecture of the system is presented followed by a description of its performance.

  10. NATO Advanced Study Institute entitled Physics of Plasma-Wall Interactions in Controlled Fusion

    CERN Document Server

    Behrisch, R; Physics of plasma-wall interactions in controlled fusion

    1986-01-01

    Controlled thermonuclear fusion is one of the possible candidates for long term energy sources which will be indispensable for our highly technological society. However, the physics and technology of controlled fusion are extremely complex and still require a great deal of research and development before fusion can be a practical energy source. For producing energy via controlled fusion a deuterium-tritium gas has to be heated to temperatures of a few 100 Million °c corres­ ponding to about 10 keV. For net energy gain, this hot plasma has to be confined at a certain density for a certain time One pro­ mising scheme to confine such a plasma is the use of i~tense mag­ netic fields. However, the plasma diffuses out of the confining magnetic surfaces and impinges on the surrounding vessel walls which isolate the plasma from the surrounding air. Because of this plasma wall interaction, particles from the plasma are lost to the walls by implantation and are partially reemitted into the plasma. In addition, wall...

  11. Deceleration of fusion-fission cycles improves mitochondrial quality control during aging.

    Directory of Open Access Journals (Sweden)

    Marc Thilo Figge

    Full Text Available Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer. Accumulation of mitochondrial dysfunction was further linked to aging. Here we applied a probabilistic modeling approach integrating our current knowledge on mitochondrial biology allowing us to simulate mitochondrial function and quality control during aging in silico. We demonstrate that cycles of fusion and fission and mitophagy indeed are essential for ensuring a high average quality of mitochondria, even under conditions in which random molecular damage is present. Prompted by earlier observations that mitochondrial fission itself can cause a partial drop in mitochondrial membrane potential, we tested the consequences of mitochondrial dynamics being harmful on its own. Next to directly impairing mitochondrial function, pre-existing molecular damage may be propagated and enhanced across the mitochondrial population by content mixing. In this situation, such an infection-like phenomenon impairs mitochondrial quality control progressively. However, when imposing an age-dependent deceleration of cycles of fusion and fission, we observe a delay in the loss of average quality of mitochondria. This provides a rational why fusion and fission rates are reduced during aging and why loss of a mitochondrial fission factor can extend life span in fungi. We propose the 'mitochondrial infectious damage adaptation' (MIDA model according to which a deceleration of fusion-fission cycles reflects a systemic adaptation increasing life span.

  12. Aurora inertial confinement fusion laser control and data acquisition system

    Energy Technology Data Exchange (ETDEWEB)

    Bowling, P.S.; Burczyk, L.; Dingler, R.D.; Shurter, R.B. (Los Alamos National Lab., P.O. Box 1663, AT-8 MS H811, Los Alamos, NM 87545)

    1987-05-01

    Aurora is a complex krypton fluoride excimer research laser supported by a computerized control and data acquisition system. Aurora's requirements for control, data aquisition, and data analysis are met with specific application of minicomputer and microcomputer capabilities coupled with internally developed custom hardware and software. A control system that provides an operator with the ability to charge and fire the integrated laser system safely and remotely is described. A data aquisition system that acquires, stores, and processes laser system data is also described. This data acquisition system provides the experimentalists with support tools for better understanding the laser system.

  13. Large distributed control system using ADA in fusion research

    Energy Technology Data Exchange (ETDEWEB)

    Woodruff, J. P., LLNL

    1998-04-21

    Construction of the National Ignition Facility laser at Lawrence Livermore National Laboratory features a large distributed control system constructed using object-oriented software engineering techniques. Control of 60,000 devices is effected using a network of some 500 computers that run software written in Ada and communicating through CORBA. The project has completed its final design review; implementation of the first of five planned increments will be delivered at the end of fiscal year 1998. Preliminary measures of the distributed controls performance confirm the design decisions reported in this paper, and the measurement and supporting simulation of full system performance continue.

  14. Brain Computer Interface-Controlling Devices Utilizing The Alpha Brain Waves

    Directory of Open Access Journals (Sweden)

    Rohan Hundia

    2015-01-01

    Full Text Available Abstract This paper describes the development and testing of an interface system whereby one can control external devices by voluntarily controlling alpha waves that is through eye movement. Such a system may be used for the control of prosthetics robotic arms and external devices like wheelchairs using the alpha brain waves and the Mu rhythm. The response generated through the movement of the eye detecting and controlling the amplitude of the alpha brain waves is interfaced and processed to control Robotic systems and smart home control. In order to measure the response of alpha waves over different lobes of the brain initially I measured these signals over 32 regions using silver chloride plated electrodes. By the opening and the closure of the eyes and the movement in the up-down left-right directions and processing these movements measuring them over the occipital region I was able to differentiate the amplitude of the alpha waves generated due to these several movements. In the First session testing period subjects were asked to close and open their eyes and they were able to control limited movements of a Robot and a prosthetic arm. In the Second 2session the movement of the eyes was also considered left-right up-down along with the opening and closure during this time span they were able to control more dimensions of the robot several devices at the same time using different eye movements.

  15. Information fusion control with time delay for smooth pursuit eye movement.

    Science.gov (United States)

    Zhang, Menghua; Ma, Xin; Qin, Bin; Wang, Guangmao; Guo, Yanan; Xu, Zhigang; Wang, Yafang; Li, Yibin

    2016-05-01

    Smooth pursuit eye movement depends on prediction and learning, and is subject to time delays in the visual pathways. In this paper, an information fusion control method with time delay is presented, implementing smooth pursuit eye movement with prediction and learning as well as solving the problem of time delays in the visual pathways. By fusing the soft constraint information of the target trajectory of eyes and the ideal control strategy, and the hard constraint information of the eye system state equation and the output equation, optimal estimations of the co-state sequence and the control variable are obtained. The proposed control method can track not only constant velocity, sinusoidal target motion, but also arbitrary moving targets. Moreover, the absolute value of the retinal slip reaches steady state after 0.1 sec. Information fusion control method elegantly describes in a function manner how the brain may deal with arbitrary target velocities, how it implements the smooth pursuit eye movement with prediction, learning, and time delays. These two principles allowed us to accurately describe visually guided, predictive and learning smooth pursuit dynamics observed in a wide variety of tasks within a single theoretical framework. The tracking control performance of the proposed information fusion control with time delays is verified by numerical simulation results.

  16. Design of power control system using SMES and SVC for fusion power plant

    Science.gov (United States)

    Niiyama, K.; Yagai, T.; Tsuda, M.; Hamajima, T.

    2008-02-01

    A SMES (Superconducting Magnetic Energy Storage System) system with converter composed of self-commutated valve devices such as GTO and IGBT is available to control active and reactive power simultaneously. A SVC (Static Var Compensators) or STATCOM (Static Synchronous Compensator) is widely employed to reduce reactive power in power plants and substations. Owing to progress of power electronics technology using GTO and IGBT devices, power converters in the SMES system and the SVC can easily control power flow in few milliseconds. Moreover, since the valve devices for the SMES are equivalent to those for the SVC, the device cost must be reduced. In this paper the basic control system combined with the SMES and SVC is designed for large pulsed loads of a nuclear fusion power plant. This combined system largely expands the reactive power control region as well as the active one. The simulation results show that the combined system is effective and prospective for the nuclear fusion power plant.

  17. The Development of BCI Using Alpha Waves for Controlling the Robot Arm

    Science.gov (United States)

    Inoue, Shinsuke; Akiyama, Yoko; Izumi, Yoshinobu; Nishijima, Shigehiro

    The highly accurate BCI using alpha waves was developed for controlling the robot arm, and real-time operation was succeeded by using noninvasive electrodes. The significant components of the alpha wave were identified by spectral analysis and confirmation of the amplitude of the alpha wave. When the alpha wave was observed in the subject, the subjects were instructed to select the multiple decision branches, concerning 7 motions (including “STOP”) of a robot arm. As a result, high accuracy (70-95%) was obtained, and the subject succeeded in transferring a small box by controlling the robot arm. Since high accuracy was obtained by use of this method, it can be applied to control equipments such as a robot arm. Since the alpha wave can be easily generated, the BCI using alpha waves does not need more training than that using other signals. Moreover, we tried to reduce the false positive errors by effectively detecting artifacts using spectral analysis and detecting signals of 50μV or more. As a result, the false positive errors could be reduced from 25% to 0%. Therefore, this technique shows great promise in the area of communication and the control of other external equipments, and will make great contribution in the improvement of Quality of Life (QOL) of mobility disabled.

  18. Position control of active magnetic levitation using sphere-shaped HTS bulk for inertial nuclear fusion

    Science.gov (United States)

    Suga, K.; Riku, K.; Agatsuma, K.; Ueda, H.; Ishiyama, A.

    2008-02-01

    We have developed an active magnetic levitation system that comprises a field-cooled disk-shaped or sphere-shaped HTS bulk and multiple ring-shaped electromagnets. In this system, the levitation height of HTS bulk can be controlled by adjusting the operating current of each electromagnet individually. Further, the application of the vertical noncontact levitation system is expected due to its levitation stability without mechanical supports. We assume that this system is applied to inertial nuclear fusion. However, one of the important issues is to achieve position control with high accuracy of the fusion fuel in order to illuminate the target evenly over the entire surface. Therefore, this system is applied to the levitation and position control of a sphere-shaped superconducting capsule containing nuclear fusion fuel. In this study, we designed and constructed a position control system for the sphere-shaped HTS bulk with a diameter of 5 mm by using numerical simulation based on hybrid finite element and boundary element analysis. We then carried out the experiment of levitation height and position control characteristics of the HTS bulk in this system. With regard to position control, accuracies within 59 ?m are obtained.

  19. TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression.

    Directory of Open Access Journals (Sweden)

    Hironori Takamura

    Full Text Available Mitochondria are dynamic organelles that change in response to extracellular stimuli. These changes are essential for normal mitochondrial/cellular function and are controlled by a tight balance between two antagonistic pathways that promote fusion and fission. Although some molecules have been identified to mediate the mitochondrial fusion and fission process, the underlying mechanisms remain unclear. Tumor necrosis factor receptor-associated protein 1 (TRAP1 is a mitochondrial molecule that regulates a variety of mitochondrial functions. Here, we examined the role of TRAP1 in the regulation of morphology. Stable TRAP1 knockdown cells showed abnormal mitochondrial morphology, and we observed significant decreases in dynamin-related protein 1 (Drp1 and mitochondrial fission factor (Mff, mitochondrial fission proteins. Similar results were obtained by transient knockdown of TRAP1 in two different cell lines, SH-SY5Y neuroblastoma cells and KNS-42 glioma cells. However, TRAP1 knockdown did not affect expression levels of fusion proteins. The reduction in Drp1 and Mff protein levels was rescued following treatment with the proteasome inhibitor MG132. These results suggest that TRAP1 regulates the expression of fission proteins and controls mitochondrial fusion/fission, which affects mitochondrial/cellular function.

  20. Information Fusion-Based Optimal Attitude Control for an Alterable Thrust Direction Unmanned Aerial Vehicle

    Directory of Open Access Journals (Sweden)

    Ziyang Zhen

    2013-01-01

    Full Text Available Attitude control is the inner‐loop and the most important part of the automatic flight control system of an unmanned aerial vehicle (UAV. The information fusion‐based optimal control method is applied in a UAV flight control system in this work. Firstly, a nonlinear model of alterable thrust direction UAV (ATD‐UAV is established and linearized for controller design. The longitudinal controller and lateral controller are respectively designed based on information fusion‐based optimal control, and then the information fusion flight control system is built up. Finally, the simulation of a nonlinear model described as ATD‐UAV is carried out, the results of which show the superiority of the information fusion‐based control strategy when compared to the single‐loop design method. We also show that the ATD technique improves the anti‐disturbance capacity of the UAV.

  1. Clinical outcomes after posterolateral lumbar fusion in workers' compensation patients: a case-control study.

    Science.gov (United States)

    Carreon, Leah Y; Glassman, Steven D; Kantamneni, Neha R; Mugavin, Mark O; Djurasovic, Mladen

    2010-09-01

    Case-control propensity matched. To compare clinical outcomes after lumbar fusion in patients receiving workers' compensation with a case-matched control group who are not on workers' compensation. Previous studies have demonstrated poor outcomes in patients receiving workers' compensation after lumbar fusion. However, a case-control study where patients are matched for covariates known to affect outcomes after lumbar fusion, including baseline clinical outcome measures, has not been done. From 783 patients who underwent posterolateral fusion with complete preoperative and 2-year postoperative outcome measures, 60 patients who were receiving workers' compensation were identified. Outcome measures included the Oswestry Disability Index (ODI), Short Form-36 (SF-36), and back and leg pain numerical rating scales. Propensity scoring technique was used to match these patients with a control group not receiving workers' compensation using sex, age, smoking status, body mass index, diagnosis, number of levels fused, preoperative ODI, SF-36 Physical Component Summary (PCS), SF-36 Mental Component Summary, and back and leg pain scores, producing 58 matched pairs. There were no significant differences between the demographics, job classification, and preoperative outcome scores in the two groups. At 2 years after operation, patients not receiving workers' compensation had a significantly greater improvement in ODI (P=0.009) and SF-36 PCS (P=0.007) compared with those receiving workers' compensation. Although patients not receiving workers' compensation had greater improvements in back and leg pain compared with those receiving workers' compensation, this did not reach statistical significance (P=0.079). The mean 2-year ODI, SF-36 PCS, and back pain raw scores of patients receiving workers' compensation were significantly lower than those not receiving workers' compensation. Only 19% of workers' compensation patients achieved minimum clinically important difference in terms

  2. Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue.

    Science.gov (United States)

    Wu, Lizhen; Zhou, Linkang; Chen, Cheng; Gong, Jingyi; Xu, Li; Ye, Jing; Li, De; Li, Peng

    2014-01-01

    Excess lipid storage in adipose tissue results in the development of obesity and other metabolic disorders including diabetes, fatty liver and cardiovascular diseases. The lipid droplet (LD) is an important subcellular organelle responsible for lipid storage. We previously observed that Fsp27, a member of the CIDE family proteins, is localized to LD-contact sites and promotes atypical LD fusion and growth. Cidea, a close homolog of Fsp27, is expressed at high levels in brown adipose tissue. However, the exact role of Cidea in promoting LD fusion and lipid storage in adipose tissue remains unknown. Here, we expressed Cidea in Fsp27-knockdown adipocytes and observed that Cidea has similar activity to Fsp27 in promoting lipid storage and LD fusion and growth. Next, we generated Cidea and Fsp27 double-deficient mice and observed that these animals had drastically reduced adipose tissue mass and a strong lean phenotype. In addition, Cidea/Fsp27 double-deficient mice had improved insulin sensitivity and were intolerant to cold. Furthermore, we observed that the brown and white adipose tissues of Cidea/Fsp27 double-deficient mice had significantly reduced lipid storage and contained smaller LDs compared to those of Cidea or Fsp27 single deficient mice. Overall, these data reveal an important role of Cidea in controlling lipid droplet fusion, lipid storage in brown and white adipose tissue, and the development of obesity.

  3. A Multiple Data Fusion Approach to Wheel Slip Control for Decentralized Electric Vehicles

    Directory of Open Access Journals (Sweden)

    Dejun Yin

    2017-04-01

    Full Text Available Currently, active safety control methods for cars, i.e., the antilock braking system (ABS, the traction control system (TCS, and electronic stability control (ESC, govern the wheel slip control based on the wheel slip ratio, which relies on the information from non-driven wheels. However, these methods are not applicable in the cases without non-driven wheels, e.g., a four-wheel decentralized electric vehicle. Therefore, this paper proposes a new wheel slip control approach based on a novel data fusion method to ensure good traction performance in any driving condition. Firstly, with the proposed data fusion algorithm, the acceleration estimator makes use of the data measured by the sensor installed near the vehicle center of mass (CM to calculate the reference acceleration of each wheel center. Then, the wheel slip is constrained by controlling the acceleration deviation between the actual wheel and the reference wheel center. By comparison with non-control and model following control (MFC cases in double lane change tests, the simulation results demonstrate that the proposed control method has significant anti-slip effectiveness and stabilizing control performance.

  4. The effect of infliximab, a monoclonal antibody against TNF-alpha, on disc herniation resorption - A randomized controlled study

    NARCIS (Netherlands)

    Autio, Reijo A.; Karppinen, Jaro; Niinimaki, Jaakko; Ojala, Risto; Veeger, Nic; Korhonen, Timo; Hurri, Heikki; Tervonen, Osmo

    2006-01-01

    Study Design. Randomized, controlled study. Objective. To evaluate the effect of infliximab on herniated nucleus pulposus (HNP) resorption. Summary of Background Data. Although the effects of tumor necrosis factor alpha (TNF-alpha) on HNP resorption are not fully understood, TNF-alpha appears to be

  5. Design quality control of the activity determination total alpha liquid effluents; Diseno de control de calidad de la determinacion de actividad alfa total en efluentes liquidos

    Energy Technology Data Exchange (ETDEWEB)

    Yague, L.; Alvarez, A.; Navarro, N.; Noguerales, C.

    2011-07-01

    The total alpha activity index is the joint action of all alpha emissions in a sample. This is a very useful in designing the analytical control of liquid effluent into the environment. Presents the design of quality control applied to the determination of total alpha activity.

  6. PGC-1alpha Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

    Directory of Open Access Journals (Sweden)

    Leone Teresa C

    2005-01-01

    Full Text Available The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha was targeted in mice. PGC-1alpha null (PGC-1alpha-/- mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phenotype. The postnatal growth of heart and slow-twitch skeletal muscle, organs with high mitochondrial energy demands, is blunted in PGC-1alpha-/- mice. With age, the PGC-1alpha-/- mice develop abnormally increased body fat, a phenotype that is more severe in females. Mitochondrial number and respiratory capacity is diminished in slow-twitch skeletal muscle of PGC-1alpha-/- mice, leading to reduced muscle performance and exercise capacity. PGC-1alpha-/- mice exhibit a modest diminution in cardiac function related largely to abnormal control of heart rate. The PGC-1alpha-/- mice were unable to maintain core body temperature following exposure to cold, consistent with an altered thermogenic response. Following short-term starvation, PGC-1alpha-/- mice develop hepatic steatosis due to a combination of reduced mitochondrial respiratory capacity and an increased expression of lipogenic genes. Surprisingly, PGC-1alpha-/- mice were less susceptible to diet-induced insulin resistance than wild-type controls. Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha-/- mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.

  7. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

    Directory of Open Access Journals (Sweden)

    Teresa C Leone

    2005-04-01

    Full Text Available The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha was targeted in mice. PGC-1alpha null (PGC-1alpha(-/- mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic phenotype. The postnatal growth of heart and slow-twitch skeletal muscle, organs with high mitochondrial energy demands, is blunted in PGC-1alpha(-/- mice. With age, the PGC-1alpha(-/- mice develop abnormally increased body fat, a phenotype that is more severe in females. Mitochondrial number and respiratory capacity is diminished in slow-twitch skeletal muscle of PGC-1alpha(-/- mice, leading to reduced muscle performance and exercise capacity. PGC-1alpha(-/- mice exhibit a modest diminution in cardiac function related largely to abnormal control of heart rate. The PGC-1alpha(-/- mice were unable to maintain core body temperature following exposure to cold, consistent with an altered thermogenic response. Following short-term starvation, PGC-1alpha(-/- mice develop hepatic steatosis due to a combination of reduced mitochondrial respiratory capacity and an increased expression of lipogenic genes. Surprisingly, PGC-1alpha(-/- mice were less susceptible to diet-induced insulin resistance than wild-type controls. Lastly, vacuolar lesions were detected in the central nervous system of PGC-1alpha(-/- mice. These results demonstrate that PGC-1alpha is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.

  8. Sliding Mode Controller with Multisensor Data Fusion for Piezo Actuated Structure

    Directory of Open Access Journals (Sweden)

    J. Arunshankar

    2011-07-01

    Full Text Available The benefits of multisensor data fusion (MSDF in controlling the piezo actuated beam structure using sliding mode controller (SMC has been brought out. The first two vibrating modes of the smart cantilever beamare measured by two sensors namely, piezoelectric sensor and laser displacement sensor. The states are estimated from the sensors outputs using information filter, which were then fused and applied as input to the controller. The controller has been designed from the linear dynamic model of a piezo actuated beam, identified using linear recursive least square (RLS method based on ARX model. A digital control system consisting of virtual instrumentation software LabVIEW, and USB data acquisition module NI 6008, was used for simulation and real-time control. Improved closed-loop performance was obtained when the controller designed used fused data, as compared to the closed-loop performance obtained with a single sensor. The beam structure considered in this work was a pilot model of the structures used in aerospace applications. Simulation and experimental results presented demonstrate the benefits of data fusion in controlling the vibration modes.Defence Science Journal, 2011, 61(4, pp.346-353, DOI:http://dx.doi.org/10.14429/dsj.61.1114

  9. a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects.

    Science.gov (United States)

    Heude, M; Fabre, F

    1993-03-01

    It has long been known that diploid strains of yeast are more resistant to gamma-rays than haploid cells, and that this is in part due to heterozygosity at the mating type (MAT) locus. It is shown here that the genetic control exerted by the MAT genes on DNA repair involves the a1 and alpha 2 genes, in a RME1-independent way. In rad18 diploids, affected in the error-prone repair, the a/alpha effects are of a very large amplitude, after both UV and gamma-rays, and also depends on a1 and alpha 2. The coexpression of a and alpha in rad18 haploids suppresses the sensitivity of a subpopulation corresponding to the G2 phase cells. Related to this, the coexpression of a and alpha in RAD+ haploids depresses UV-induced mutagenesis in G2 cells. For srs2 null diploids, also affected in the error-prone repair pathway, we show that their G1 UV sensitivity, likely due to lethal recombination events, is partly suppressed by MAT homozygosity. Taken together, these results led to the proposal that a1-alpha 2 promotes a channeling of some DNA structures from the mutagenic into the recombinational repair process.

  10. Fusion ignition research experiment

    Energy Technology Data Exchange (ETDEWEB)

    Dale Meade

    2000-07-18

    Understanding the properties of high gain (alpha-dominated) fusion plasmas in an advanced toroidal configuration is the largest remaining open issue that must be addressed to provide the scientific foundation for an attractive magnetic fusion reactor. The critical parts of this science can be obtained in a compact high field tokamak which is also likely to provide the fastest and least expensive path to understanding alpha-dominated plasmas in advanced toroidal systems.

  11. Sensor fusion IV: Control paradigms and data structures; Proceedings of the Meeting, Boston, MA, Nov. 12-15, 1991

    Science.gov (United States)

    Schenker, Paul S. (Editor)

    1992-01-01

    Various papers on control paradigms and data structures in sensor fusion are presented. The general topics addressed include: decision models and computational methods, sensor modeling and data representation, active sensing strategies, geometric planning and visualization, task-driven sensing, motion analysis, models motivated biology and psychology, decentralized detection and distributed decision, data fusion architectures, robust estimation of shapes and features, application and implementation. Some of the individual subjects considered are: the Firefly experiment on neural networks for distributed sensor data fusion, manifold traversing as a model for learning control of autonomous robots, choice of coordinate systems for multiple sensor fusion, continuous motion using task-directed stereo vision, interactive and cooperative sensing and control for advanced teleoperation, knowledge-based imaging for terrain analysis, physical and digital simulations for IVA robotics.

  12. Sensor fusion IV: Control paradigms and data structures; Proceedings of the Meeting, Boston, MA, Nov. 12-15, 1991

    Science.gov (United States)

    Schenker, Paul S. (Editor)

    1992-01-01

    Various papers on control paradigms and data structures in sensor fusion are presented. The general topics addressed include: decision models and computational methods, sensor modeling and data representation, active sensing strategies, geometric planning and visualization, task-driven sensing, motion analysis, models motivated biology and psychology, decentralized detection and distributed decision, data fusion architectures, robust estimation of shapes and features, application and implementation. Some of the individual subjects considered are: the Firefly experiment on neural networks for distributed sensor data fusion, manifold traversing as a model for learning control of autonomous robots, choice of coordinate systems for multiple sensor fusion, continuous motion using task-directed stereo vision, interactive and cooperative sensing and control for advanced teleoperation, knowledge-based imaging for terrain analysis, physical and digital simulations for IVA robotics.

  13. Construction of a linker library with widely controllable flexibility for fusion protein design.

    Science.gov (United States)

    Li, Gang; Huang, Ziliang; Zhang, Chong; Dong, Bo-Jun; Guo, Ruo-Hai; Yue, Hong-Wei; Yan, Li-Tang; Xing, Xin-Hui

    2016-01-01

    Flexibility or rigidity of the linker between two fused proteins is an important parameter that affects the function of fusion proteins. In this study, we constructed a linker library with five elementary units based on the combination of the flexible (GGGGS) and the rigid (EAAAK) units. Molecular dynamics (MD) simulation showed that more rigid units in the linkers lead to more helical conformation and hydrogen bonds, and less distance fluctuation between the N- and C-termini of the linker. The diversity of linker flexibility of the linker library was then studied by fluorescence resonance energy transfer (FRET) of cyan fluorescent protein (CFP)-yellow fluorescent protein (YFP) fusion proteins, which showed that there is a wide range of distribution of the FRET efficiency. Dissipative particle dynamics (DPD) simulation of CFP-YFP with different linkers also gave identical results with that of FRET efficiency analysis, and we further found that the combination manner of the linker peptide had a remarkable effect on the orientation of CFP and YFP domains. Our studies demonstrated that the construction of the linker library with the widely controllable flexibility could provide appropriate linkers with the desirable characteristics to engineer the fusion proteins with the expected functions.

  14. Data fusion: a new concept in non-destructive testing; Fusion de donnees: un nouveau concept en controle non destructif

    Energy Technology Data Exchange (ETDEWEB)

    Georgel, B.; Lavayssiere, B.

    1995-12-31

    Non-destructive testing of some components (made of austenitic steel, or of a complex shape for example) requires quite often the use of several methods such as X-ray, ultrasonics, Eddy Currents. Then, a skilled operator is able to perform the expertise of the specimen. The main goal of this paper is to show that 3D diagnosis may be improved in term of reliability and precision by fusion of several NDT techniques. A data fusion algorithm is more that trying to improve the visualisation or the rendering of NDT data sets. It consists for each volume element, in computing a new value representing the combined information and in formulating a diagnosis on this basis. To achieve such a goal, know-how in modeling of physical phenomena and in applied mathematics is crucial. (authors). 4 refs., 2 figs.

  15. Fusion Plasma Theory project summaries

    Energy Technology Data Exchange (ETDEWEB)

    1993-10-01

    This Project Summary book is a published compilation consisting of short descriptions of each project supported by the Fusion Plasma Theory and Computing Group of the Advanced Physics and Technology Division of the Department of Energy, Office of Fusion Energy. The summaries contained in this volume were written by the individual contractors with minimal editing by the Office of Fusion Energy. Previous summaries were published in February of 1982 and December of 1987. The Plasma Theory program is responsible for the development of concepts and models that describe and predict the behavior of a magnetically confined plasma. Emphasis is given to the modelling and understanding of the processes controlling transport of energy and particles in a toroidal plasma and supporting the design of the International Thermonuclear Experimental Reactor (ITER). A tokamak transport initiative was begun in 1989 to improve understanding of how energy and particles are lost from the plasma by mechanisms that transport them across field lines. The Plasma Theory program has actively-participated in this initiative. Recently, increased attention has been given to issues of importance to the proposed Tokamak Physics Experiment (TPX). Particular attention has been paid to containment and thermalization of fast alpha particles produced in a burning fusion plasma as well as control of sawteeth, current drive, impurity control, and design of improved auxiliary heating. In addition, general models of plasma behavior are developed from physics features common to different confinement geometries. This work uses both analytical and numerical techniques. The Fusion Theory program supports research projects at US government laboratories, universities and industrial contractors. Its support of theoretical work at universities contributes to the office of Fusion Energy mission of training scientific manpower for the US Fusion Energy Program.

  16. Multiple DSP system for real time parallel processing and feedback control on fusion experiments

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, A.P.; Correia, C.M.B.; Varandas, C.A.F. [Associacao EURATOM, Lisboa (Portugal). Nucl. Inst. Superior Tecnico; Schneider, F. [Association EURATOM/IPP, Max-Planck-Institut fuer Plasmaphysik, D-85748 Garching (Germany)

    1999-01-01

    This paper describes a specially designed system for real time parallel processing and feedback control on fusion experiments. The system is being implemented in PCI and VME modules, based on an array of four synchronizable DSPs, with 1 Mbyte of global RAM, 12 bits resolution, four analog inputs with sampling frequency up to 40 MSPS, two analog or waveform generator outputs with an update rate up to 100 MSPS, eight digital opto-coupled inputs/outputs and one external global trigger optical input. The user interface appears as a virtual instrument from LabView for Windows. (orig.) 7 refs.

  17. Anti-hepatitis B virus activity and mechanisms of recombinant human serum albumin-interferon-alpha-2b fusion protein in vitro and in vivo.

    Science.gov (United States)

    Bingfa, Xu; Qinglin, Fan; Hui, Huang; Canjun, Wang; Wei, Wei; Lihua, Song

    2009-01-01

    To evaluate the anti-hepatitis B virus (anti-HBV) effects and mechanisms of recombinant human serum albumin-interferon-alpha-2b fusion protein (rHSA-IFNalpha-2b) in vitro and in vivo. The inhibiting effects on HBV replication were examined in the HepG2 2.2.15 cell line and in ducks, and the expressions of signal transducers and transactivator 1 (STAT1), IFN-stimulated gene factor 3 (ISGF3) and 2',5'-oligoadenylate synthetase 1 (OAS1) were investigated by the reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis. In vitro,at concentrations from 0.075 to 1.2 nmol/l, rHSA-IFNalpha-2b inhibited the releases of extracellular hepatitis B surface antigen, hepatitis B e antigen and HBV DNA in a dose-dependent manner; rHSA- IFNalpha-2b also increased the levels of STAT1, ISGF3 and OAS1. In vivo, rHSA-IFNalpha-2b reduced the levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin and duck hepatitis B virus (DHBV) DNA in the sera of DHBV-infected ducks. We provide the first evidence that rHSA-IFNalpha-2b significantly inhibits HBV replication in HepG2 2.2.15 cells and in ducks, and that the antiviral effect of rHSA-IFNalpha-2b in vivo is more potent than that of IFNalpha-2b. The anti-HBV mechanism probably operates by triggering the JAK-STAT signaling pathway and increasing the expression of OAS1. Copyright 2009 S. Karger AG, Basel.

  18. Swarm Robot Control for Human Services and Moving Rehabilitation by Sensor Fusion

    Directory of Open Access Journals (Sweden)

    Tresna Dewi

    2014-01-01

    Full Text Available A current trend in robotics is fusing different types of sensors having different characteristics to improve the performance of a robot system and also benefit from the reduced cost of sensors. One type of robot that requires sensor fusion for its application is the service robot. To achieve better performance, several service robots are preferred to work together, and, hence, this paper concentrates on swarm service robots. Swarm service mobile robots operating within a fixed area need to cope with dynamic changes in the environment, and they must also be capable of avoiding dynamic and static obstacles. This study applies sensor fusion and swarm concept for service mobile robots in human services and rehabilitation environment. The swarm robots follow the human moving trajectory to provide support to human moving and perform several tasks required in their living environment. This study applies a reference control and proportional-integral (PI control for the obstacle avoidance function. Various computer simulations are performed to verify the effectiveness of the proposed method.

  19. Gas Transport and Control in Thick-Liquid Inertial Fusion PowerPlants

    Energy Technology Data Exchange (ETDEWEB)

    Debonnel, Christophe Sylvain [Univ. of California, Berkeley, CA (United States)

    2006-01-01

    Among the numerous potential routes to a commercial fusion power plant, the inertial path with thick-liquid protection is explored in this doctoral dissertation. Gas dynamics phenomena in such fusion target chambers have been investigated since the early 1990s with the help of a series of simulation codes known as TSUNAMI. For this doctoral work, the code was redesigned and rewritten entirely to enable the use of modern programming techniques, languages and software; improve its user-friendliness; and refine its ability to model thick-liquid protected chambers. The new ablation and gas dynamics code is named “Visual Tsunami” to emphasize its graphics-based pre- and post-processors. It is aimed at providing a versatile and user-friendly design tool for complex systems for which transient gas dynamics phenomena play a key role. Simultaneously, some of these improvements were implemented in a previous version of the code; the resulting code constitutes the version 2.8 of the TSUNAMI series. Visual Tsunami was used to design and model the novel Condensation Debris Experiment (CDE), which presents many aspects of a typical Inertial Fusion Energy (IFE) system and has therefore been used to exercise the code. Numerical and experimental results are in good agreement. In a heavy-ion IFE target chamber, proper beam and target propagation set stringent requirements for the control of ablation debris transport in the target chamber and beam tubes. When the neutralized ballistic transport mode is employed, the background gas density should be adequately low and the beam tube metallic surfaces upstream of the neutralizing region should be free of contaminants. TSUNAMI 2.8 was used for the first simulation of gas transport through the complex geometry of the liquid blanket of a hybrid target chamber and beam lines. Concurrently, the feasibility of controlling the gas density was addressed with a novel beam tube design, which introduces magnetic shutters and a long low

  20. Control of a laser inertial confinement fusion-fission power plant

    Energy Technology Data Exchange (ETDEWEB)

    Moses, Edward I.; Latkowski, Jeffery F.; Kramer, Kevin J.

    2015-10-27

    A laser inertial-confinement fusion-fission energy power plant is described. The fusion-fission hybrid system uses inertial confinement fusion to produce neutrons from a fusion reaction of deuterium and tritium. The fusion neutrons drive a sub-critical blanket of fissile or fertile fuel. A coolant circulated through the fuel extracts heat from the fuel that is used to generate electricity. The inertial confinement fusion reaction can be implemented using central hot spot or fast ignition fusion, and direct or indirect drive. The fusion neutrons result in ultra-deep burn-up of the fuel in the fission blanket, thus enabling the burning of nuclear waste. Fuels include depleted uranium, natural uranium, enriched uranium, spent nuclear fuel, thorium, and weapons grade plutonium. LIFE engines can meet worldwide electricity needs in a safe and sustainable manner, while drastically shrinking the highly undesirable stockpiles of depleted uranium, spent nuclear fuel and excess weapons materials.

  1. Top-Down Control of Visual Alpha Oscillations: Sources of Control Signals and Their Mechanisms of Action.

    Science.gov (United States)

    Wang, Chao; Rajagovindan, Rajasimhan; Han, Sahng-Min; Ding, Mingzhou

    2016-01-01

    Alpha oscillations (8-12 Hz) are thought to inversely correlate with cortical excitability. Goal-oriented modulation of alpha has been studied extensively. In visual spatial attention, alpha over the region of visual cortex corresponding to the attended location decreases, signifying increased excitability to facilitate the processing of impending stimuli. In contrast, in retention of verbal working memory, alpha over visual cortex increases, signifying decreased excitability to gate out stimulus input to protect the information held online from sensory interference. According to the prevailing model, this goal-oriented biasing of sensory cortex is effected by top-down control signals from frontal and parietal cortices. The present study tests and substantiates this hypothesis by (a) identifying the signals that mediate the top-down biasing influence, (b) examining whether the cortical areas issuing these signals are task-specific or task-independent, and (c) establishing the possible mechanism of the biasing action. High-density human EEG data were recorded in two experimental paradigms: a trial-by-trial cued visual spatial attention task and a modified Sternberg working memory task. Applying Granger causality to both sensor-level and source-level data we report the following findings. In covert visual spatial attention, the regions exerting top-down control over visual activity are lateralized to the right hemisphere, with the dipoles located at the right frontal eye field (FEF) and the right inferior frontal gyrus (IFG) being the main sources of top-down influences. During retention of verbal working memory, the regions exerting top-down control over visual activity are lateralized to the left hemisphere, with the dipoles located at the left middle frontal gyrus (MFG) being the main source of top-down influences. In both experiments, top-down influences are mediated by alpha oscillations, and the biasing effect is likely achieved via an inhibition

  2. Human Factors and Data Fusion as Part of Control Systems Resilience

    Energy Technology Data Exchange (ETDEWEB)

    David I. Gertman

    2009-05-01

    Human performance and human decision making is counted upon as a crucial aspect of overall system resilience. Advanced control systems have the potential to provide operators and asset owners a wide range of data, deployed at different levels that can be used to support operator situation awareness. However, the sheer amount of data available can make it challenging for operators to assimilate information and respond appropriately. This paper reviews some of the challenges and issues associated with providing operators with actionable state awareness and argues for the over arching importance of integrating human factors as part of intelligent control systems design and implementation. It is argued that system resilience is improved by implementing human factors in operations and maintenance. This paper also introduces issues associated with resilience and data fusion and highlights areas in which human factors including field studies hold promise.

  3. Robust EMG sensing system based on data fusion for myoelectric control of a robotic arm

    Directory of Open Access Journals (Sweden)

    Soria Carlos M

    2009-02-01

    Full Text Available Abstract Background Myoelectric control of a robotic manipulator may be disturbed by failures due to disconnected electrodes, interface impedance changes caused by movements, problems in the recording channel and other various noise sources. To correct these problems, this paper presents two fusing techniques, Variance Weighted Average (VWA and Decentralized Kalman Filter (DKF, both based on the myoelectric signal variance as selecting criterion. Methods Tested in five volunteers, a redundant arrangement was obtained with two pairs of electrodes for each recording channel. The myoelectric signals were electronically amplified, filtered and digitalized, while the processing, fusion algorithms and control were implemented in a personal computer under MATLAB® environment and in a Digital Signal Processor (DSP. The experiments used an industrial robotic manipulator BOSCH SR-800, type SCARA, with four degrees of freedom; however, only the first joint was used to move the end effector to a desired position, the latter obtained as proportional to the EMG amplitude. Results Several trials, including disconnecting and reconnecting one electrode and disturbing the signal with synthetic noise, were performed to test the fusion techniques. The results given by VWA and DKF were transformed into joint coordinates and used as command signals to the robotic arm. Even though the resultant signal was not exact, the failure was ignored and the joint reference signal never exceeded the workspace limits. Conclusion The fault robustness and safety characteristics of a myoelectric controlled manipulator system were substantially improved. The proposed scheme prevents potential risks for the operator, the equipment and the environment. Both algorithms showed efficient behavior. This outline could be applied to myoelectric control of prosthesis, or assistive manipulators to better assure the system functionality when electrode faults or noisy environment are present.

  4. Robust EMG sensing system based on data fusion for myoelectric control of a robotic arm.

    Science.gov (United States)

    López, Natalia M; di Sciascio, Fernando; Soria, Carlos M; Valentinuzzi, Max E

    2009-02-25

    Myoelectric control of a robotic manipulator may be disturbed by failures due to disconnected electrodes, interface impedance changes caused by movements, problems in the recording channel and other various noise sources. To correct these problems, this paper presents two fusing techniques, Variance Weighted Average (VWA) and Decentralized Kalman Filter (DKF), both based on the myoelectric signal variance as selecting criterion. Tested in five volunteers, a redundant arrangement was obtained with two pairs of electrodes for each recording channel. The myoelectric signals were electronically amplified, filtered and digitalized, while the processing, fusion algorithms and control were implemented in a personal computer under MATLAB environment and in a Digital Signal Processor (DSP). The experiments used an industrial robotic manipulator BOSCH SR-800, type SCARA, with four degrees of freedom; however, only the first joint was used to move the end effector to a desired position, the latter obtained as proportional to the EMG amplitude. Several trials, including disconnecting and reconnecting one electrode and disturbing the signal with synthetic noise, were performed to test the fusion techniques. The results given by VWA and DKF were transformed into joint coordinates and used as command signals to the robotic arm. Even though the resultant signal was not exact, the failure was ignored and the joint reference signal never exceeded the workspace limits. The fault robustness and safety characteristics of a myoelectric controlled manipulator system were substantially improved. The proposed scheme prevents potential risks for the operator, the equipment and the environment. Both algorithms showed efficient behavior. This outline could be applied to myoelectric control of prosthesis, or assistive manipulators to better assure the system functionality when electrode faults or noisy environment are present.

  5. Cold nuclear fusion

    National Research Council Canada - National Science Library

    Huang Zhenqiang Huang Yuxiang

    2013-01-01

    ...... And with a magnetic moment of light nuclei controlled cold nuclear collide fusion, belongs to the nuclear energy research and development in the field of applied technology "cold nuclear collide fusion...

  6. Data fusion control and guidance of surface-to-air missile under the complex circumstance based on neural-net technology

    Institute of Scientific and Technical Information of China (English)

    Zhou Deyun; Zhou Feng

    2008-01-01

    Under the complicated electromagnetism circumstance,the model of data fusion control and guidance of surface-to-air missile weapon systems is established.Such ways and theories as Elman-NN,radar tracking and niter's data fusion net based on the group method for data-processing (GMRDF) are applied to constructing the model of data fusion.The highly reliable state estimation of the tracking targets and the improvement in accuracy of control and guidance are obtained.The purpose is optimization design of data fusion control and guidance of surface-to-air missile weapon systems and improving the fighting effectiveness of surface-to-air missile weapon systems.

  7. ATCA/AXIe compatible board for fast control and data acquisition in nuclear fusion experiments

    Energy Technology Data Exchange (ETDEWEB)

    Batista, A.J.N., E-mail: toquim@ipfn.ist.utl.pt [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear - Laboratorio Associado, Instituto Superior Tecnico - Universidade Tecnica de Lisboa, Lisboa (Portugal); Leong, C.; Bexiga, V. [INESC-ID, Lisboa (Portugal); Rodrigues, A.P.; Combo, A.; Carvalho, B.B.; Fortunato, J.; Correia, M. [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear - Laboratorio Associado, Instituto Superior Tecnico - Universidade Tecnica de Lisboa, Lisboa (Portugal); Teixeira, J.P.; Teixeira, I.C. [INESC-ID, Lisboa (Portugal); Sousa, J.; Goncalves, B.; Varandas, C.A.F. [Associacao EURATOM/IST, Instituto de Plasmas e Fusao Nuclear - Laboratorio Associado, Instituto Superior Tecnico - Universidade Tecnica de Lisboa, Lisboa (Portugal)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer High performance board for fast control and data acquisition. Black-Right-Pointing-Pointer Large IO channel number per board with galvanic isolation. Black-Right-Pointing-Pointer Optimized for high reliability and availability. Black-Right-Pointing-Pointer Targeted for nuclear fusion experiments with long duration discharges. Black-Right-Pointing-Pointer To be used on the ITER Fast Plant System Controller prototype. - Abstract: An in-house development of an Advanced Telecommunications Computing Architecture (ATCA) board for fast control and data acquisition, with Input/Output (IO) processing capability, is presented. The architecture, compatible with the ATCA (PICMG 3.4) and ATCA eXtensions for Instrumentation (AXIe) specifications, comprises a passive Rear Transition Module (RTM) for IO connectivity to ease hot-swap maintenance and simultaneously to increase cabling life cycle. The board complies with ITER Fast Plant System Controller (FPSC) guidelines for rear IO connectivity and redundancy, in order to provide high levels of reliability and availability to the control and data acquisition systems of nuclear fusion devices with long duration plasma discharges. Simultaneously digitized data from all Analog to Digital Converters (ADC) of the board can be filtered/decimated in a Field Programmable Gate Array (FPGA), decreasing data throughput, increasing resolution, and sent through Peripheral Component Interconnect (PCI) Express to multi-core processors in the ATCA shelf hub slots. Concurrently the multi-core processors can update the board Digital to Analog Converters (DAC) in real-time. Full-duplex point-to-point communication links between all FPGAs, of peer boards inside the shelf, allow the implementation of distributed algorithms and Multi-Input Multi-Output (MIMO) systems. Support for several timing and synchronization solutions is also provided. Some key features are onboard ADC or DAC modules with galvanic isolation

  8. alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells.

    Science.gov (United States)

    Cailleteau, Laurence; Estrach, Soline; Thyss, Raphael; Boyer, Laurent; Doye, Anne; Domange, Barbara; Johnsson, Nils; Rubinstein, Eric; Boucheix, Claude; Ebrahimian, Teni; Silvestre, Jean-Sebastien; Lemichez, Emmanuel; Meneguzzi, Guerrino; Mettouchi, Amel

    2010-07-15

    Integrin receptors and their extracellular matrix ligands provide cues to cell proliferation, survival, differentiation and migration. Here, we show that alpha2beta1 integrin, when ligated to the basement membrane component laminin-1, triggers a proliferation arrest in primary endothelial cells. Indeed, in the presence of strong growth signals supplied by growth factors and fibronectin, alpha2beta1 engagement alters assembly of mature focal adhesions by alpha5beta1 and leads to impairment of downstream signaling and cell-cycle arrest in the G1 phase. Although the capacity of alpha5beta1 to signal for GTP loading of Rac is preserved, the joint engagement of alpha2beta1 interferes with membrane anchorage of Rac. Adapting the 'split-ubiquitin' sensor to screen for membrane-proximal alpha2 integrin partners, we identified the CD9 tetraspanin and further establish its requirement for destabilization of focal adhesions, control of Rac subcellular localization and growth arrest induced by alpha2beta1 integrin. Altogether, our data establish that alpha2beta1 integrin controls endothelial cell commitment towards quiescence by triggering a CD9-dependent dominant signaling.

  9. ADS-B and multilateration sensor fusion algorithm for air traffic control

    Science.gov (United States)

    Liang, Mengchen

    Air traffic is expected to increase rapidly in the next decade. But, the current Air Traffic Control (ATC) system does not meet the demand of the future safety and efficiency. The Next Generation Air Transportation System (NextGen) is a transformation program for the ATC system in the United States. The latest estimates by Federal Aviation Administration (FAA) show that by 2018 NextGen will reduce total delays in flight by 35 percent and provide 23 billion dollars in cumulative benefits. A satellite-based technology called the Automatic Dependent Surveillance-Broadcast (ADS-B) system is one of the most important elements in NextGen. FAA expects that ADS-B systems will be available in the National Airspace System (NAS) by 2020. However, an alternative surveillance system is needed due to vulnerabilities that exist in ADS-B systems. Multilateration has a high accuracy performance and is believed to be an ideal back-up strategy for ADS-B systems. Thus, in this study, we develop the ADS-B and multilateration sensor fusion algorithm for aircraft tracking applications in ATC. The algorithm contains a fault detection function for ADS-B information monitoring by using Trajectory Change Points reports from ADS-B and numerical vectors from a hybrid estimation algorithm. We consider two types of faults in the ADS-B measurement model to show that the algorithm is able to deal with the bad data from ADS-B systems and automatically select good data from multilateration systems. We apply fuzzy logic concepts and generate time variant parameters during the fusion process. The parameters play a role of weights for combining data from different sensors. The algorithm performance is validated through two aircraft tracking examples.

  10. Targeting at the Nanoscale: A Novel S-Layer Fusion Protein Enabling Controlled Immobilization of Biotinylated Molecules.

    Science.gov (United States)

    Varga, Melinda

    2016-11-04

    With the aim of constructing an S-layer fusion protein that combines both excellent self-assembly and specific ligand i.e., biotin binding ability, streptavidin (aa 16-133) was fused to the S-layer protein of Sporosarcina ureae ATCC 13881 (SslA) devoid of its N-terminal 341 and C-terminal 172 amino acids. The genetically engineered chimeric protein could be successfully produced in E. coli, isolated, and purified via Ni affinity chromatography. In vitro recrystallisation experiments performed with the purified chimeric protein in solution and on a silicon wafer have demonstrated that fusion of the streptavidin domain does not interfere with the self-assembling properties of the S-layer part. The chimeric protein self-assembled into multilayers. More importantly, the streptavidin domain retained its full biotin-binding ability, a fact evidenced by experiments in which biotinylated quantum dots were coupled to the fusion protein monomers and adsorbed onto the in vitro recrystallised fusion protein template. In this way, this S-layer fusion protein can serve as a functional template for the controlled immobilization of biotinylated and biologically active molecules.

  11. Sensor fusion: lane marking detection and autonomous intelligent cruise control system

    Science.gov (United States)

    Baret, Marc; Baillarin, S.; Calesse, C.; Martin, Lionel

    1995-12-01

    In the past few years MATRA and RENAULT have developed an Autonomous Intelligent Cruise Control (AICC) system based on a LIDAR sensor. This sensor incorporating a charge coupled device was designed to acquire pulsed laser diode emission reflected by standard car reflectors. The absence of moving mechanical parts, the large field of view, the high measurement rate and the very good accuracy for distance range and angular position of targets make this sensor very interesting. It provides the equipped car with the distance and the relative speed of other vehicles enabling the safety distance to be controlled by acting on the throttle and the automatic gear box. Experiments in various real traffic situations have shown the limitations of this kind of system especially on bends. All AICC sensors are unable to distinguish between a bend and a change of lane. This is easily understood if we consider a road without lane markings. This fact has led MATRA to improve its AICC system by providing the lane marking information. Also in the scope of the EUREKA PROMETHEUS project, MATRA and RENAULT have developed a lane keeping system in order to warn of the drivers lack of vigilance. Thus, MATRA have spread this system to far field lane marking detection and have coupled it with the AICC system. Experiments will be carried out on roads to estimate the gain in performance and comfort due to this fusion.

  12. Low energy cost for optimal speed and control of membrane fusion.

    Science.gov (United States)

    François-Martin, Claire; Rothman, James E; Pincet, Frederic

    2017-02-07

    Membrane fusion is the cell's delivery process, enabling its many compartments to receive cargo and machinery for cell growth and intercellular communication. The overall activation energy of the process must be large enough to prevent frequent and nonspecific spontaneous fusion events, yet must be low enough to allow it to be overcome upon demand by specific fusion proteins [such as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs)]. Remarkably, to the best of our knowledge, the activation energy for spontaneous bilayer fusion has never been measured. Multiple models have been developed and refined to estimate the overall activation energy and its component parts, and they span a very broad range from 20 kBT to 150 kBT, depending on the assumptions. In this study, using a bulk lipid-mixing assay at various temperatures, we report that the activation energy of complete membrane fusion is at the lowest range of these theoretical values. Typical lipid vesicles were found to slowly and spontaneously fully fuse with activation energies of ∼30 kBT Our data demonstrate that the merging of membranes is not nearly as energy consuming as anticipated by many models and is ideally positioned to minimize spontaneous fusion while enabling rapid, SNARE-dependent fusion upon demand.

  13. Controlling stimulated Raman scattering by two-color light in inertial confinement fusion

    Science.gov (United States)

    Liu, Z. J.; Chen, Y. H.; Zheng, C. Y.; Cao, L. H.; Li, B.; Xiang, J.; Hao, L.; Lan, K.

    2017-08-01

    A method is proposed to control the stimulated Raman scattering in the inertial confinement fusion by using auxiliary 2ω light to suppress the stimulated Raman scattering of the 3ω light. In this scheme, inverse bremsstrahlung absorption and parametric instabilities in the 2ω light increase the electron temperature and the plasma-density fluctuation, thus preventing the development of Raman scattering of the 3ω light. This scheme is successfully demonstrated by both one-dimensional kinetic simulations and two-dimensional radiative hydrodynamic simulations. The one-dimensional Vlasov results show that the time-averaged transmissivity of the 3ω light increases from 0.75 to 0.95 under certain conditions. Results obtained using the particle-in-cell method with Monte Carlo collisions show that the electron temperature is greatly increased with the increasing intensity of the 2ω light. The two-dimensional radiative hydrodynamic simulation results show that the electron temperature increases from 3.2 keV to 3.5 keV, and the time-averaged backscattering level decreases from 0.28 to 0.1 in the presence of the auxiliary 2ω light.

  14. Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci

    NARCIS (Netherlands)

    T. Trimborn (Tolleiv); J.H. Gribnau (Joost); P.J. Fraser (Peter); F.G. Grosveld (Frank)

    1999-01-01

    textabstractWe have characterized mRNA expression and transcription of the mouse alpha- and beta-globin loci during development. S1 nuclease and primary transcript in situ hybridization analyses demonstrate that all seven murine globin genes (zeta, alpha1, alpha2, epsil

  15. G alpha12 is targeted to the mitochondria and affects mitochondrial morphology and motility.

    Science.gov (United States)

    Andreeva, Alexandra V; Kutuzov, Mikhail A; Voyno-Yasenetskaya, Tatyana A

    2008-08-01

    G alpha12 constitutes, along with G alpha13, one of the four families of alpha subunits of heterotrimeric G proteins. We found that the N terminus of G alpha12, but not those of other G alpha subunits, contains a predicted mitochondrial targeting sequence. Using confocal microscopy and cell fractionation, we demonstrated that up to 40% of endogenous G alpha12 in human umbilical vein endothelial cells colocalize with mitochondrial markers. N-terminal sequence of G alpha12 fused to GFP efficiently targeted the fusion protein to mitochondria. G alpha12 with mutated mitochondrial targeting sequence was still located in mitochondria, suggesting the existence of additional mechanisms for mitochondrial localization. Lysophosphatidic acid, one of the known stimuli transduced by G alpha12/13, inhibited mitochondrial motility, while depletion of endogenous G alpha12 increased mitochondrial motility. G alpha12Q229L variants uncoupled from RhoGEFs (but not fully functional activated G alpha12Q229L) induced transformation of the mitochondrial network into punctate mitochondria and resulted in a loss of mitochondrial membrane potential. All examined G alpha12Q229L variants reduced phosphorylation of Bcl-2 at Ser-70, while only mutants unable to bind RhoGEFs also decreased cellular levels of Bcl-2. These G alpha12 mutants were also more efficient Hsp90 interactors. These findings are the first demonstration of a heterotrimeric G protein alpha subunit specifically targeted to mitochondria and involved in the control of mitochondrial morphology and dynamics.

  16. PREFACE: 30th EPS Conference on Controlled Fusion and Plasma Physics

    Science.gov (United States)

    Koch, R.; Lebedev, S.

    2003-12-01

    The 30th EPS Conference on Controlled Fusion and Plasma Physics took place in St Petersburg, Russian Federation, on 7th--11th July 2003. It was jointly organized by the Ioffe Physico-Technical Institute, the St Petersburg State Polytechnical University and Technical University Applied Physics Ltd, on behalf of the Plasma Physics Division of the European Physical Society (EPS). The members of the local organizing committee were drawn from these institutions: B Kuteev, Chair, Polytechnical University S Lebedev, Vice-Chair, Ioffe Institute A Lebedev, Scientific Secretary, Ioffe Institute V Bakharev, TUAP Ltd V Grigor'yants, Ioffe Institute V Sergeev, Polytechnical University N Zhubr, Ioffe Institute Over the years, the annual conference of the Plasma Physics Division of the European Physical Society has widened its scope. Contributions to the present conference covered widely diversified fields of plasma physics, ranging from magnetic and inertial fusion to low temperature plasmas. Plasma sizes under investigation ranged from tiny to astronomical. The topics covered during the conference were distributed over the following categories: tokamaks, stellarators, high intensity laser produced plasmas and inertial confinement, alternative magnetic confinement, plasma edge physics, plasma heating and current drive, diagnostics, basic plasma physics, astrophysical and geophysical plasmas and low temperature plasmas. The scientific programme and paper selection were the responsibility of the Programme Committee appointed by the Board of the EPS Plasma Physics Division. The committee was composed of: R Koch, Chairman, ERM/KMS Brussels, Belgium E Ascasibar, CIEMAT Madrid, Spain S Atzeni, Università di Roma, Italy G Bonhomme, LPMI Nancy, France C Chiuderi, Università di Firenze, Italy B Kuteev, St Petersburg State Polytechnical,University, Russian Federation M Mauel, Contact person APS-DPP, Columbia University New York, USA R A Pitts, EPFL/CRPP Lausanne, Switzerland R Salomaa

  17. Control of silicification by genetically engineered fusion proteins: Silk–silica binding peptides

    Science.gov (United States)

    Zhou, Shun; Huang, Wenwen; Belton, David J.; Simmons, Leo O.; Perry, Carole C.; Wang, Xiaoqin; Kaplan, David L.

    2014-01-01

    In the present study, an artificial spider silk gene, 6mer, derived from the consensus sequence of Nephila clavipes dragline silk gene, was fused with different silica-binding peptides (SiBPs), A1, A3 and R5, to study the impact of the fusion protein sequence chemistry on silica formation and the ability to generate a silk–silica composite in two different bioinspired silicification systems: solution–solution and solution– solid. Condensed silica nanoscale particles (600–800 nm) were formed in the presence of the recombinant silk and chimeras, which were smaller than those formed by 15mer-SiBP chimeras [1], revealing that the molecular weight of the silk domain correlated to the sizes of the condensed silica particles in the solution system. In addition, the chimeras (6mer-A1/A3/R5) produced smaller condensed silica particles than the control (6mer), revealing that the silica particle size formed in the solution system is controlled by the size of protein assemblies in solution. In the solution–solid interface system, silicification reactions were performed on the surface of films fabricated from the recombinant silk proteins and chimeras and then treated to induce β-sheet formation. A higher density of condensed silica formed on the films containing the lowest β-sheet content while the films with the highest β-sheet content precipitated the lowest density of silica, revealing an inverse correlation between the β-sheet secondary structure and the silica content formed on the films. Intriguingly, the 6mer-A3 showed the highest rate of silica condensation but the lowest density of silica deposition on the films, compared with 6mer-A1 and -R5, revealing antagonistic crosstalk between the silk and the SiBP domains in terms of protein assembly. These findings offer a path forward in the tailoring of biopolymer–silica composites for biomaterial related needs. PMID:25462851

  18. Controlled alpha-sexithiophene nanostructure formation in standard and inverted configuration organic solar cells

    DEFF Research Database (Denmark)

    Radziwon, Michal Jędrzej; Goszczak, Arkadiusz Jaroslaw; Fernandes Cauduro, André Luis

    Owing to tremendous research efforts, the efficiency of organic small molecule solar cells has increased substantially over the past decade and has now surpassed the 10% efficiency limit. An important factor affecting the performance of such solar cells is the morphology of the n- and p......-type domains in the active organic layer. The molecular packing in these is of same importance, as it strongly affects the carrier transport in the cells. In this work, we present the study of alpha-sexithiophene (α 6T) temperature dependent growth for standard, on gold anodes, and inverted, on electron...... accepting C60 layers, solar cell configurations. Furthermore, a comparative study of the correlation between the α-6T morphology and device performance parameters for standard and inverted solar cell configurations is presented. The morphology of the α 6T layer is controlled by means of the substrate...

  19. [Human life and energy production. Prospects opened up by controlled thermonuclear fusion].

    Science.gov (United States)

    Escande, D

    1997-03-18

    The massive and presently increasing energy production is going to confront mankind with a very important problem in the forthcoming decades, in particular due to the vanishing of resources and to the greenhouse effect. The share of fossil fuels in the energy production will have to decrease, and other energy sources will be needed. Among them controlled thermonuclear fusion has may assets due to its non-radioactive fuel with plentiful supply, its non radioactive and non polluting ashes, its safety, its weak environmental impact, and its irrelevance to nuclear proliferation in a normal setting. During the last three decades, physicists have made a series of steps toward the peaceful use of the dominant source of energy in the Universe. They have learned how to confine by magnetic fields plasmas at temperatures of 200 millions degrees centigrade, and they have developed several specific technologies. This way, they produced 11 million watts of nuclear power by fusing two isotopes of hydrogen. These investigations are conducted in a responsible spirit, that of ecoproduction, where possible negative consequences are anticipated, are made as low as reasonably achievable, and their management is studied. Yet several fundamental issues still have to be solved before on economically efficient industrial thermonuclear power plant be operated. A huge international collaboration involving Japan, the USA, the Russian Federation, and the European Union joined with Switzerland and Canada, is presently designing the first experimental thermonuclear reactor, the International Thermonuclear Experimental Reactor (ITER). It would cost 9 billion dollars, a cost similar to other large scientific projects. This is an important step toward an electricity producing thermonuclear reactor that would be both safe and respectful of human health and of environment.

  20. Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication.

    Science.gov (United States)

    Wang, Chunfu; Pflugheber, Jill; Sumpter, Rhea; Sodora, Donald L; Hui, Daniel; Sen, Ganes C; Gale, Michael

    2003-04-01

    Hepatitis C virus (HCV) infection is treated with interferon (IFN)-based therapy. The mechanisms by which IFN suppresses HCV replication are not known, and only limited efficacy is achieved with therapy because the virus directs mechanisms to resist the host IFN response. In the present study we characterized the effects of IFN action upon the replication of two distinct quasispecies of an HCV replicon whose encoded NS5A protein exhibited differential abilities to bind and inhibit protein kinase R (PKR). Metabolic labeling experiments revealed that IFN had little overall effect upon HCV protein stability or polyprotein processing but specifically blocked translation of the HCV RNA, such that the replication of both viral quasispecies was suppressed by IFN treatment of the Huh7 host cells. However, within cells expressing an NS5A variant that inhibited PKR, we observed a reduced level of eukaryotic initiation factor 2 alpha subunit (eIF2alpha) phosphorylation and a concomitant increase in HCV protein synthetic rates, enhancement of viral RNA replication, and a partial rescue of viral internal ribosome entry site (IRES) function from IFN suppression. Assessment of the ribosome distribution of the HCV replicon RNA demonstrated that the NS5A-mediated block in eIF2alpha phosphorylation resulted in enhanced recruitment of the HCV RNA into polyribosome complexes in vivo but only partially rescued the RNA from polyribosome dissociation induced by IFN treatment. Examination of cellular proteins associated with HCV-translation complexes in IFN-treated cells identified the P56 protein as an eIF3-associated factor that fractionated with the initiator ribosome-HCV RNA complex. Importantly, we found that P56 could independently suppress HCV IRES function both in vitro and in vivo, but a mutant P56 that was unable to bind eIF3 had no suppressive action. We conclude that IFN blocks HCV replication through translational control programs involving PKR and P56 to, respectively

  1. Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling.

    Science.gov (United States)

    Parikh, Vinay; Ji, Jinzhao; Decker, Michael W; Sarter, Martin

    2010-03-03

    One-second-long increases in prefrontal cholinergic activity ("transients") were demonstrated previously to be necessary for the incorporation of cues into ongoing cognitive processes ("cue detection"). Nicotine and, more robustly, selective agonists at alpha4beta2* nicotinic acetylcholine receptors (nAChRs) enhance cue detection and attentional performance by augmenting prefrontal cholinergic activity. The present experiments determined the role of beta2-containing and alpha7 nAChRs in the generation of prefrontal cholinergic and glutamatergic transients in vivo. Transients were evoked by nicotine, the alpha4beta2* nAChR agonist ABT-089 [2-methyl-3-(2-(S)-pyrrolindinylmethoxy) pyridine dihydrochloride], or the alpha7 nAChR agonist A-582941 [2-methyl-5-(6-phenyl-pyridazin-3-yl)-octahydro-pyrrolo[3,4-c]pyrrole]. Transients were recorded in mice lacking beta2 or alpha7 nAChRs and in rats after removal of thalamic glutamatergic or midbrain dopaminergic inputs to prefrontal cortex. The main results indicate that stimulation of alpha4beta2* nAChRs evokes glutamate release and that the presence of thalamic afferents is necessary for the generation of cholinergic transients. ABT-089-evoked transients were completely abolished in mice lacking beta2* nAChRs. The amplitude, but not the decay rate, of nicotine-evoked transients was reduced by beta2* knock-out. Conversely, in mice lacking the alpha7 nAChR, the decay rate, but not the amplitude, of nicotine-evoked cholinergic and glutamatergic transients was attenuated. Substantiating the role of alpha7 nAChR in controlling the duration of release events, stimulation of alpha7 nAChR produced cholinergic transients that lasted 10- to 15-fold longer than those evoked by nicotine. alpha7 nAChR-evoked cholinergic transients are mediated in part by dopaminergic activity. Prefrontal alpha4beta2* nAChRs play a key role in evoking and facilitating the transient glutamatergic-cholinergic interactions that are necessary for cue detection

  2. Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1.

    Science.gov (United States)

    Degenhardt, Tatjana; Väisänen, Sami; Rakhshandehroo, Maryam; Kersten, Sander; Carlberg, Carsten

    2009-05-01

    Heme is an essential prosthetic group of proteins involved in oxygen transport, energy metabolism and nitric oxide production. ALAS1 (5-aminolevulinate synthase) is the rate-limiting enzyme in heme synthesis in the liver and is highly regulated to adapt to the metabolic demand of the hepatocyte. In the present study, we describe human hepatic ALAS1 as a new direct target for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). In primary human hepatocytes and in HepG2 cells, PPARalpha agonists induced an increase in ALAS1 mRNA levels, which was abolished by PPARalpha silencing. These effects are mediated by two functional PPAR binding sites at positions -9 and -2.3 kb relative to the ALAS1 transcription start site. PPARalpha ligand treatment also up-regulated the mRNA levels of the genes ALAD (5-aminolevulinate dehydratase), UROS (uroporphyrinogen III synthase), UROD (uroporphyrinogen decarboxylase), CPOX (coproporphyrinogen oxidase) and PPOX (protoporphyrinogen oxidase) encoding for enzymes controlling further steps in heme biosynthesis. In HepG2 cells treated with PPARalpha agonists and in mouse liver upon fasting, the association of PPARalpha, its partner retinoid X receptor, PPARgamma co-activator 1alpha and activated RNA polymerase II with the transcription start site region of all six genes was increased, leading to higher levels of the metabolite heme. In conclusion, these data strongly support a role of PPARalpha in the regulation of human ALAS1 and of five additional genes of the pathway, consequently leading to increased heme synthesis.

  3. Comparison of standard fusion with a "topping off" system in lumbar spine surgery: a protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Kaulhausen Thomas

    2011-10-01

    Full Text Available Abstract Background Fusion of lumbar spine segments is a well-established therapy for many pathologies. The procedure changes the biomechanics of the spine. Initial clinical benefits may be outweighed by ensuing damage to the adjacent segments. Various surgical devices and techniques have been developed to prevent this deterioration. "Topping off" systems combine rigid fusion with a flexible pedicle screw system to prevent adjacent segment disease (ASD. To date, there is no convincing evidence that these devices provide any patient benefits. Methods/Design The study is designed as a randomized, therapy-controlled trial in a clinical care setting at a university hospital. Patients presenting to the outpatient clinic with degenerative disc disease or spondylolisthesis will be assessed against study inclusion and exclusion criteria. After randomization, the control group will undergo conventional fusion. The intervention group will undergo fusion with a supplemental flexible pedicle screw system to protect the adjacent segment ("topping off". Follow-up examination will take place immediately after treatment during hospital stay, after 6 weeks, and then after 6, 12, 24 and 36 months. Subsequently, ongoing assessments will be performed annually. Outcome measurements will include quality of life and pain assessments using questionnaires (SF-36™, ODI, COMI. In addition, clinical and radiologic ASD, work-related disability, and duration of work disability will be assessed. Inpatient and 6-month mortality, surgery-related data (e.g., intraoperative complications, blood loss, length of incision, surgical duration, postoperative complications, adverse events, and serious adverse events will be documented and monitored throughout the study. Cost-effectiveness analysis will also be provided. Discussion New hybrid systems might improve the outcome of lumbar spine fusion. To date, there is no convincing published data on effectiveness or safety of these

  4. Contributions to 28th European physical society conference on controlled fusion and plasma physics (Madeira Tecnopolo, Funchal, Portugal, 18-22 June 2001) from LHD experiment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The LHD experimental group has presented nineteen papers at the 28th European Physical Society Conference on Controlled Fusion and Plasma Physics (Madeira Tecnopolo, Funchal, Portugal, 18-22 June 2001). The contributed papers are collected in this report. (author)

  5. Annual report of the Summit Members' Working Group on Controlled Thermonuclear Fusion (Fusin Working Group (FWG))

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1987-04-01

    The Summit Members' Working Group on Controlled Thermonuclear Fusion (Fusion Working Group (FWG)) was established in 1983 in response to the Declaration of the Heads of State and Government at the Versailles Economic Summit meeting of 1982, and in response to the subsequent report of the Working Group in Technology, Growth and Employment (TGE) as endorsed at the Williamsburg Summit meeting, 1983. This document contains the complete written record of each of the three FWG meetings which include the minutes, lists of attendees, agendas, statements, and summary conclusions as well as the full reports of the Technical Working Party. In addition, there is a pertinent exchange of correspondence between FWG members on the role of the Technical Working Party and a requested background paper on the modalities associated with a possible future ETR project.

  6. Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth.

    Science.gov (United States)

    Usmani, Shirine E; Pest, Michael A; Kim, Gunwoo; Ohora, Sara N; Qin, Ling; Beier, Frank

    2012-07-01

    We have recently identified transforming growth factor alpha (TGFα) as a novel growth factor involved in the joint disease osteoarthritis. The role of TGFα in normal cartilage and bone physiology however, has not been well defined. The objective of this study was to determine the role of TGFα in bone development through investigation of the Tgfa knockout mouse. The gross skeletons as well as the cartilage growth plates of Tgfa knockout mice and their control littermates were examined during several developmental stages ranging from newborn to ten weeks old. Knockout mice experienced skeletal growth retardation and expansion of the hypertrophic zone of the growth plate. These phenotypes were transient and spontaneously resolved by ten weeks of age. Tgfa knockout growth plates also had fewer osteoclasts along the cartilage/bone interface. Furthermore, knockout mice expressed less RUNX2, RANKL, and MMP13 mRNA in their cartilage growth plates than controls did. Tgfa knockout mice experience a delay in bone development, specifically the conversion of hypertrophic cartilage to true bone. The persistence of the hypertrophic zone of the growth plate appears to be mediated by a decrease in MMP13 and RANKL expression in hypertrophic chondrocytes and a resulting reduction in osteoclast recruitment. Overall, TGFα appears to be an important growth factor regulating the conversion of cartilage to bone during the process of endochondral ossification. Copyright © 2012 Elsevier Inc. All rights reserved.

  7. Controlling alpha tracks registration in Makrofol DE 1-1 detector

    Science.gov (United States)

    Hassan, N. M.; Hanafy, M. S.; Naguib, A.; El-Saftawy, A. A.

    2017-09-01

    Makrofol DE 1-1 is a recent type of solid state nuclear track detectors could be used to measure radon concentration in the environment throughout the detection of α-particles emitted from radon decay. Thus, studying the physical parameters that control the formation of alpha tracks is vital for environmental radiation protection. Makrofol DE 1-1 polycarbonate detector was irradiated by α-particles of energies varied from 2 to 5 MeV emitted from the 241Am source of α-particle energy of 5.5 MeV. Then, the detector was etched in an optimum etching solution of mixed ethyl alcohol in KOH aqueous solution of (85% (Vol.) of 6 M KOH + 15% (Vol.) C2H5OH) at 50 °C for 3 h. Afterward, the bulk etch rate, etching sensitivity, and the registration efficiency of the detector, which control the tracks registration, were measured. The bulk etch rate of Makrofol detector was found to be 3.71 ± 0.71 μm h-1. The etching sensitivity and the detector registration efficiency were decreased exponentially with α-particles' energies following Bragg curve. A precise registration of α-particle was presented in this study. Therefore, Makrofol DE 1-1 can be applied as a radiation dosimeter as well as radon and thoron monitors.

  8. Fusion d'images: application au contr\\^ole de la distribution des biopsies prostatiques

    CERN Document Server

    Mozer, Pierre; Chevreau, G; Troccaz, Jocelyne

    2008-01-01

    This paper is about the application of a 3D ultrasound data fusion technique to the 3D reconstruction of prostate biopies in a reference volume. The method is introduced and its evaluation on a series of data coming from 15 patients is described.

  9. Atomic data for controlled fusion research. Volume III. Particle interactions with surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, E.W.

    1985-02-01

    This report provides a handbook of data concerning particle solid interactions that are relevant to plasma-wall interactions in fusion devices. Published data have been collected, assessed, and represented by a single functional relationship which is presented in both tabular and graphical form. Mechanisms reviewed here include sputtering, secondary electron emission, particle reflection, and trapping.

  10. Modulation of Posterior Alpha Activity by Spatial Attention Allows for Controlling A Continuous Brain-Computer Interface

    NARCIS (Netherlands)

    Horschig, J.M.; Oosterheert, W.; Oostenveld, R.; Jensen, O.

    2014-01-01

    Here we report that the modulation of alpha activity by covert attention can be used as a control signal in an online brain-computer interface, that it is reliable, and that it is robust. Subjects were instructed to orient covert visual attention to the left or right hemifield. We decoded the

  11. ITER Plasma at Ion Cyclotron Frequency Domain: The Fusion Alpha Particles Diagnostics Based on the Stimulated Raman Scattering of Fast Magnetosonic Wave off High Harmonic Ion Bernstein Modes

    Science.gov (United States)

    Stefan, V. Alexander

    2014-10-01

    A novel method for alpha particle diagnostics is proposed. The theory of stimulated Raman scattering, SRS, of the fast wave and ion Bernstein mode, IBM, turbulence in multi-ion species plasmas, (Stefan University Press, La Jolla, CA, 2008). is utilized for the diagnostics of fast ions, (4)He (+2), in ITER plasmas. Nonlinear Landau damping of the IBM on fast ions near the plasma edge leads to the space-time changes in the turbulence level, (inverse alpha particle channeling). The space-time monitoring of the IBM turbulence via the SRS techniques may prove efficient for the real time study of the fast ion velocity distribution function, spatial distribution, and transport. Supported by Nikola Tesla Labs., La Jolla, CA 92037.

  12. Magnetic fusion technology

    CERN Document Server

    Dolan, Thomas J

    2014-01-01

    Magnetic Fusion Technology describes the technologies that are required for successful development of nuclear fusion power plants using strong magnetic fields. These technologies include: ? magnet systems, ? plasma heating systems, ? control systems, ? energy conversion systems, ? advanced materials development, ? vacuum systems, ? cryogenic systems, ? plasma diagnostics, ? safety systems, and ? power plant design studies. Magnetic Fusion Technology will be useful to students and to specialists working in energy research.

  13. ATF-2 controls transcription of Maspin and GADD45 alpha genes independently from p53 to suppress mammary tumors.

    Science.gov (United States)

    Maekawa, T; Sano, Y; Shinagawa, T; Rahman, Z; Sakuma, T; Nomura, S; Licht, J D; Ishii, S

    2008-02-14

    The activating transcription factor, ATF-2, is a target of p38 and JNK that are involved in stress-induced apoptosis. Heterozygous Atf-2 mutant (Atf-2+/-) mice are highly prone to mammary tumors. The apoptosis-regulated gene GADD45alpha and the breast cancer suppressor gene Maspin, both of which are known to be p53 target genes, are downregulated in the mammary tumors arisen in Atf-2+/- mice. Here, we have analysed how ATF-2 controls the transcription of GADD45alpha and Maspin. ATF-2 and p53 independently activate the GADD45alpha transcription. ATF-2 does not directly bind to the GADD45alpha promoter; instead, it is recruited via Oct-1 and NF-I. ATF-2 simultaneously binds to Oct-1, NF-I and breast cancer suppressor BRCA1 to activate transcription. With regard to Maspin, ATF-2 and p53 directly bind to different sites in the Maspin promoter to independently activate its transcription. Consistent with the observation that ATF-2 and p53 independently activate the transcription of Maspin and GADD45alpha is that the loss of one copy of p53 shortened the period required for mammary tumor development in Atf-2+/- mice. These studies suggest the functional link between the ATF-2 and the two tumor suppressors BRCA1 and p53.

  14. Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function

    DEFF Research Database (Denmark)

    Hansen, Sara K; Párrizas, Marcelina; Jensen, Maria L;

    2002-01-01

    , and consequently in reduced HNF-1alpha-dependent activation. These findings provide genetic evidence that HNF-1alpha serves as an upstream regulator of HNF-4alpha and interacts directly with the P2 promoter in human pancreatic cells. Furthermore, they indicate that this regulation is essential to maintain normal...... in human islets and exocrine cells is primarily mediated by the P2 promoter. Furthermore, we describe a G --> A mutation in a conserved nucleotide position of the HNF-1alpha binding site of the P2 promoter, which cosegregates with MODY. The mutation results in decreased affinity for HNF-1alpha...

  15. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells.

    Science.gov (United States)

    Guillemain, Ghislaine; Muñoz-Alonso, Maria J; Cassany, Aurélia; Loizeau, Martine; Faussat, Anne-Marie; Burnol, Anne-Françoise; Leturque, Armelle

    2002-05-15

    Glucose is required for an efficient expression of the glucose transporter GLUT2 and other genes. We have shown previously that the intracytoplasmic loop of GLUT2 can divert a signal, resulting in the stimulation of glucose-sensitive gene transcription. In the present study, by interaction with the GLUT2 loop, we have cloned the rat karyopherin alpha2, a receptor involved in nuclear import. The specificity of the binding was restricted to GLUT2, and not GLUT1 or GLUT4, and to karyopherin alpha2, not alpha1. When rendered irreversible by a cross-linking agent, this transitory interaction was detected in vivo in hepatocytes. A role for karyopherin alpha2 in the transcription of two glucose-sensitive genes was investigated by transfection of native and inactive green fluorescent protein-karyopherin alpha2 in GLUT2-expressing hepatoma cells. The amount of inactive karyopherin alpha2 receptor reduced, in a dose-dependent manner, the GLUT2 and liver pyruvate kinase mRNA levels by competition with endogenous active receptor. In contrast, the overexpression of karyopherin alpha2 did not significantly stimulate GLUT2 and liver pyruvate kinase mRNA accumulation in green fluorescent protein-sorted cells. The present study suggests that, in concert with glucose metabolism, karyopherin alpha2 transmits a signal to the nucleus to regulate glucose-sensitive gene expression. The transitory tethering of karyopherin alpha2 to GLUT2 at the plasma membrane might indicate that the receptor can load the cargo to be imported locally.

  16. Improving Vehicle Ride and Handling Using LQG CNF Fusion Control Strategy for an Active Antiroll Bar System

    Directory of Open Access Journals (Sweden)

    N. Zulkarnain

    2014-01-01

    Full Text Available This paper analyses a comparison of performance for an active antiroll bar (ARB system using two types of control strategy. First of all, the LQG control strategy is investigated and then a novel LQG CNF fusion control method is developed to improve the performances on vehicle ride and handling for an active antiroll bar system. However, the ARB system has to balance the trade-off between ride and handling performance, where the CNF consists of a linear feedback law and a nonlinear feedback law. Typically, the linear feedback is designed to yield a quick response at the initial stage, while the nonlinear feedback law is used to smooth out overshoots in the system output when it approaches the target reference. The half car model is combined with a linear single track model with roll dynamics which are used for the analysis and simulation of ride and handling. The performances of the control strategies are compared and the simulation results show the LQG CNF fusion improves the performances in vehicle ride and handling.

  17. Mesolimbic alpha-, but not beta-adrenoceptors control the accumbal release of dopamine that is derived from reserpine-sensitive storage vesicles.

    NARCIS (Netherlands)

    Verheij, M.M.M.; Cools, A.R.

    2009-01-01

    Mesolimbic beta-, but not alpha-adrenoceptors control the accumbal release of dopamine that is derived from alpha-methyl-para-tyrosine-sensitive pools of newly synthesized neurotransmitter. The aim of this study was to investigate which of these adrenoceptors control the accumbal release of dopamine

  18. Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse.

    Science.gov (United States)

    Soares, Helena; Henriques, Ricardo; Sachse, Martin; Ventimiglia, Leandro; Alonso, Miguel A; Zimmer, Christophe; Thoulouze, Maria-Isabel; Alcover, Andrés

    2013-10-21

    How the vesicular traffic of signaling molecules contributes to T cell receptor (TCR) signal transduction at the immunological synapse remains poorly understood. In this study, we show that the protein tyrosine kinase Lck, the TCRζ subunit, and the adapter LAT traffic through distinct exocytic compartments, which are released at the immunological synapse in a differentially regulated manner. Lck vesicular release depends on MAL protein. Synaptic Lck, in turn, conditions the calcium- and synaptotagmin-7-dependent fusion of LAT and TCRζ containing vesicles. Fusion of vesicles containing TCRζ and LAT at the synaptic membrane determines not only the nanoscale organization of phosphorylated TCRζ, ZAP70, LAT, and SLP76 clusters but also the presence of phosphorylated LAT and SLP76 in interacting signaling nanoterritories. This mechanism is required for priming IL-2 and IFN-γ production and may contribute to fine-tuning T cell activation breadth in response to different stimulatory conditions.

  19. Optical control of fusion of microparticles in solution and simultaneous spectrophotometric measurements.

    Science.gov (United States)

    Yao, H; Ikeda, H; Inoue, Y; Kitamura, N

    1996-12-01

    A multibeam laser manipulation technique has been applied to noncontact and nondestructive optical fusion of two dye-containing microdroplets or that of a dye/water droplet and a porous silica gel particle in solution. Characteristics of the dye/particle(s) before and after coalescence have been followed simultaneously by microspectroscopy. Application of the multibeam laser manipulation-spectroscopy method in microanalytical chemistry is discussed.

  20. Consumer-oriented social data fusion: controlled learning in social environments, social advertising, and more

    Science.gov (United States)

    Grewe, L.

    2013-05-01

    This paper explores the current practices in social data fusion and analysis as it applies to consumer-oriented applications in a slew of areas including business, economics, politics, sciences, medicine, education and more. A categorization of these systems is proposed and contributions to each area are explored preceded by a discussion of some special issues related to social data and networks. From this work, future paths of consumer-based social data analysis research and current outstanding problems are discovered.

  1. Cryogenic hydrogen fuel for controlled inertial confinement fusion (formation of reactor-scale cryogenic targets)

    Science.gov (United States)

    Aleksandrova, I. V.; Koresheva, E. R.; Krokhin, O. N.; Osipov, I. E.

    2016-12-01

    In inertial fusion energy research, considerable attention has recently been focused on low-cost fabrication of a large number of targets by developing a specialized layering module of repeatable operation. The targets must be free-standing, or unmounted. Therefore, the development of a target factory for inertial confinement fusion (ICF) is based on methods that can ensure a cost-effective target production with high repeatability. Minimization of the amount of tritium (i.e., minimization of time and space at all production stages) is a necessary condition as well. Additionally, the cryogenic hydrogen fuel inside the targets must have a structure (ultrafine layers—the grain size should be scaled back to the nanometer range) that supports the fuel layer survivability under target injection and transport through the reactor chamber. To meet the above requirements, significant progress has been made at the Lebedev Physical Institute (LPI) in the technology developed on the basis of rapid fuel layering inside moving free-standing targets (FST), also referred to as the FST layering method. Owing to the research carried out at LPI, unique experience has been gained in the development of the FST-layering module for target fabrication with an ultrafine fuel layer, including a reactor- scale target design. This experience can be used for the development of the next-generation FST-layering module for construction of a prototype of a target factory for power laser facilities and inertial fusion power plants.

  2. Cryogenic hydrogen fuel for controlled inertial confinement fusion (formation of reactor-scale cryogenic targets)

    Energy Technology Data Exchange (ETDEWEB)

    Aleksandrova, I. V.; Koresheva, E. R., E-mail: elena.koresheva@gmail.com; Krokhin, O. N. [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation); Osipov, I. E. [Power Efficiency Centre, Inter RAO UES (Russian Federation)

    2016-12-15

    In inertial fusion energy research, considerable attention has recently been focused on low-cost fabrication of a large number of targets by developing a specialized layering module of repeatable operation. The targets must be free-standing, or unmounted. Therefore, the development of a target factory for inertial confinement fusion (ICF) is based on methods that can ensure a cost-effective target production with high repeatability. Minimization of the amount of tritium (i.e., minimization of time and space at all production stages) is a necessary condition as well. Additionally, the cryogenic hydrogen fuel inside the targets must have a structure (ultrafine layers—the grain size should be scaled back to the nanometer range) that supports the fuel layer survivability under target injection and transport through the reactor chamber. To meet the above requirements, significant progress has been made at the Lebedev Physical Institute (LPI) in the technology developed on the basis of rapid fuel layering inside moving free-standing targets (FST), also referred to as the FST layering method. Owing to the research carried out at LPI, unique experience has been gained in the development of the FST-layering module for target fabrication with an ultrafine fuel layer, including a reactor- scale target design. This experience can be used for the development of the next-generation FST-layering module for construction of a prototype of a target factory for power laser facilities and inertial fusion power plants.

  3. The activity of barley alpha-amylase on starch granules is enhanced by fusion of a starch binding domain from Aspergillus niger glucoamylase

    DEFF Research Database (Denmark)

    Juge, N.; Nøhr, J.; Le Gal-Coëffet, M.-F.

    2006-01-01

    High affinity for starch granules of certain amylolytic enzymes is mediated by a separate starch binding domain (SBD). In Aspergillus niger glucoamylase (GA-I), a 70 amino acid O-glycosylated peptide linker connects SBD with the catalytic domain. A gene was constructed to encode barley alpha......-amylase 1 (AMY1) fused C-terminally to this SBD via a 37 residue GA-I linker segment. AMY1-SBD was expressed in A. niger, secreted using the AMY1 signal sequence at 25 mg x L(-1) and purified in 50% yield. AMY1-SBD contained 23% carbohydrate and consisted of correctly N-terminally processed multiple forms...

  4. Cognitive control in the intertrial interval: evidence from EEG alpha power.

    Science.gov (United States)

    Compton, Rebecca J; Arnstein, Daniel; Freedman, Gili; Dainer-Best, Justin; Liss, Alison

    2011-05-01

    This study used electroencephalogram (EEG) power spectrum analyses to characterize neural activity during the intertrial interval, a period during which online cognitive adjustments in response to errors or conflict are thought to occur. EEG alpha power was quantified as an inverse index of cerebral activity during the period between each response and the next stimulus in a Stroop task. Alpha power was significantly reduced following error responses compared to correct responses, indicating greater cerebral activity following errors. Reduced alpha power was also observed following Stroop conflict trials compared to no-conflict trials, suggesting that conflict engages processes of mental adjustment. Finally, hemispheric differences in alpha power during the intertrial interval supported the complementary roles of the left and right hemispheres in behavioral activation and inhibition.

  5. Relation of central alpha-adrenoceptor and other receptors to the control of renin secretion.

    Science.gov (United States)

    Ganong, W F

    1983-02-01

    The location and nature of the receptors in the brain on which clonidine acts to decrease renin secretion have been investigated in dogs. Clonidine was injected into the vertebral and carotid arteries, and its effects were compared with those of norepinephrine and epinephrine when injected into the third ventricle. It was also injected intravenously (IV) after transection of the brain stem and following treatment with intraventricular 6-hydroxydopamine. The results suggest that the renin-regulating receptors are located in the brain stem in a region different from the receptors mediating the depressor response, that they are alpha 2-adrenoceptors, and that they are postsynaptic in location. Central alpha 1-adrenoceptors appear to mediate increased renin secretion. Central serotonergic receptors also mediate increased renin secretion, but it is not known how the alpha 1- and alpha 2-adrenoceptors interact with the serotonergic systems.

  6. Characteristics of a high-power RF source of negative hydrogen ions for neutral beam injection into controlled fusion devices

    Science.gov (United States)

    Abdrashitov, G. F.; Belchenko, Yu. I.; Gusev, I. A.; Ivanov, A. A.; Kondakov, A. A.; Sanin, A. L.; Sotnikov, O. Z.; Shikhovtsev, I. V.

    2017-01-01

    An injector of hydrogen atoms with an energy of 0.5-1 MeV and equivalent current of up to 1.5 A for purposes of controlled fusion research is currently under design at the Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences. Within this project, a multiple-aperture RF surface-plasma source of negative hydrogen ions is designed. The source design and results of experiments on the generation of a negative ion beam with a current of >1 A in the long-pulse mode are presented.

  7. Control of islet intercellular adhesion molecule-1 expression by interferon-alpha and hypoxia.

    Science.gov (United States)

    Chakrabarti, D; Huang, X; Beck, J; Henrich, J; McFarland, N; James, R F; Stewart, T A

    1996-10-01

    The ability of interferon-alpha (IFN-alpha) to induce the adhesion molecules that characterize the islets of patients with type I diabetes has been investigated. We have found that all tested recombinant IFN-as will induce major histocompatibility complex (MHC) class I on arterial endothelial cells. Some but not all IFN-as will induce intercellular adhesion molecule-1 (ICAM-1). However, there is only a transient and modest increase in VCAM on arterial endothelial cells. IFN-alpha has very little effect on endothelial MHC class II expression but will induce these proteins on monocytes. Thus, there is a close concordance between the biological actions of IFN-alpha and the appearance of those adhesion molecules induced in the islets of patients with type I diabetes. IFN-alpha is also produced in normal human islets during short-term cultures, probably as a result of the ischemia present at the center of the islet. This induction of IFN-alpha by hypoxia may explain the previously reported spontaneous induction of ICAM-1 in human islets and may also be a contributing factor to the failure of islet grafts.

  8. {sup 16}O Coulomb dissociation: towards a new means to determine the {sup 12}C+{alpha} fusion rate in stars

    Energy Technology Data Exchange (ETDEWEB)

    Fleurot, F. [Kernfysisch Versneller Instituut, Zernikelaan 25, 9747 AA Groningen (Netherlands)]. E-mail: fleurot@snolab.ca; Berg, A.M. van den [Kernfysisch Versneller Instituut, Zernikelaan 25, 9747 AA Groningen (Netherlands); Davids, B. [Kernfysisch Versneller Instituut, Zernikelaan 25, 9747 AA Groningen (Netherlands); Harakeh, M.N. [Kernfysisch Versneller Instituut, Zernikelaan 25, 9747 AA Groningen (Netherlands); Kravchuk, V.L. [Kernfysisch Versneller Instituut, Zernikelaan 25, 9747 AA Groningen (Netherlands); Wilschut, H.W. [Kernfysisch Versneller Instituut, Zernikelaan 25, 9747 AA Groningen (Netherlands)]. E-mail: wilschut@kvi.nl; Guillot, J. [IPN, 15 rue Georges Clemenceau, 91406 Orsay cedex (France); Laurent, H. [IPN, 15 rue Georges Clemenceau, 91406 Orsay cedex (France); Willis, A. [IPN, 15 rue Georges Clemenceau, 91406 Orsay cedex (France); Assuncao, M. [CSNSM, bat. 104-108, 91405 Orsay Campus (France); Kiener, J. [CSNSM, bat. 104-108, 91405 Orsay Campus (France); Lefebvre, A. [CSNSM, bat. 104-108, 91405 Orsay Campus (France); Sereville, N. de [CSNSM, bat. 104-108, 91405 Orsay Campus (France); Tatischeff, V. [CSNSM, bat. 104-108, 91405 Orsay Campus (France)

    2005-06-02

    A feasibility study was made of an important aspect of the Coulomb-dissociation method, which has been proposed for the determination of the rate of the astrophysically important {sup 12}C({alpha}, {gamma}){sup 16}O reaction. A crucial aspect is the disentanglement of nuclear and Coulomb interactions on one hand and the separation of dipole and quadrupole contributions on the other. As a first step the resonant breakup via two well-known 2{sup +} states of {sup 16}O was measured. The differential cross section of {sup 208}Pb({sup 16}O, {sup 16}O*){sup 208}Pb and the angular correlations of the fragments {sup 12}C and {alpha} in the center of mass were measured and compared to theoretical predictions calculated in DWBA and the coupled-channel method. The best agreement was found for the state at 11.52 MeV associated to a one-step excitation from the ground state, while the 9.84 MeV requires coupling to the first-excited 2{sup +} state and is not well described.

  9. Pre-cue fronto-occipital alpha phase and distributed cortical oscillations predict failures of cognitive control.

    Science.gov (United States)

    Hamm, Jordan P; Dyckman, Kara A; McDowell, Jennifer E; Clementz, Brett A

    2012-05-16

    Cognitive control is required for correct performance on antisaccade tasks, including the ability to inhibit an externally driven ocular motor response (a saccade to a peripheral stimulus) in favor of an internally driven ocular motor goal (a saccade directed away from a peripheral stimulus). Healthy humans occasionally produce errors during antisaccade tasks, but the mechanisms associated with such failures of cognitive control are uncertain. Most research on cognitive control failures focuses on poststimulus processing, although a growing body of literature highlights a role of intrinsic brain activity in perceptual and cognitive performance. The current investigation used dense array electroencephalography and distributed source analyses to examine brain oscillations across a wide frequency bandwidth in the period before antisaccade cue onset. Results highlight four important aspects of ongoing and preparatory brain activations that differentiate error from correct antisaccade trials: (1) ongoing oscillatory beta (20-30 Hz) power in anterior cingulate before trial initiation (lower for error trials); (2) instantaneous phase of ongoing alpha/theta (7 Hz) in frontal and occipital cortices immediately before trial initiation (opposite between trial types); (3) gamma power (35-60 Hz) in posterior parietal cortex 100 ms before cue onset (greater for error trials); and (4) phase locking of alpha (5-12 Hz) in parietal and occipital cortices immediately before cue onset (lower for error trials). These findings extend recently reported effects of pre-trial alpha phase on perception to cognitive control processes and help identify the cortical generators of such phase effects.

  10. Optimal control of a class of nonlinear parabolic PDE systems arising in fusion plasma current profile dynamics

    Science.gov (United States)

    Ou, Yongsheng

    The need for new sources of energy is expected to become a critical problem within the next few decades. Nuclear fusion arises as a potential source of energy with sufficient energy density to supply the world population with its steadily increasing energy demands. The need to optimize the tokamak concept for the design of an economical, possibly steady state, fusion power plant have motivated extensive international research aimed at finding the so-called "advanced tokamak (AT) operation scenarios." It has been demonstrated that simultaneous real-time control of the current and pressure profiles could lead to the steady state sustainment of an internal transport barrier (ITB), and so to a stationary optimized plasma regime. It has also been suggested that global current profile control, eventually combined with pressure profile control, can be an effective mechanism for neoclassical tearing mode (NTM) control and avoidance. The control of linear or quasi-linear parabolic diffusion-reaction partial differential equations (PDE) has been extensively studied using interior control (see [1] and references therein) or boundary control (see [2] and references therein). Recently, the control of bilinear parabolic partial differential equations via actuation of the diffusive coefficient term, named diffusivity control here, has caught increasing interest. The diffusive coefficient term in a parabolic PDE is not necessary fixed or uncontrollable. For example, the diffusivity control problem arises in the control of the current density profile in magnetically confined fusion plasmas [3], where physical actuators such as plasma total current, line-averaged density and non-inductive total power are used to steer the plasma current density to a desired profile in a designated time period. By modulating these physical actuators it is possible not only to vary the amount of non-inductive current driven into the system (interior control) and the total plasma current (boundary

  11. Controlled Aggregation and Increased Stability of β-Glucuronidase by Cellulose Binding Domain Fusion

    Science.gov (United States)

    Kim, Moonjung; Kwon, Kil Koang; Fu, Yaoyao; Kim, Haseong; Lee, Hyewon; Lee, Dae-Hee; Jung, Heungchae; Lee, Seung-Goo

    2017-01-01

    Cellulose-binding domains (CBDs) are protein domains with cellulose-binding activity, and some act as leaders in the localization of cellulosomal scaffoldin proteins to the hydrophobic surface of crystalline cellulose. In this study, we found that a CBD fusion enhanced and improved soluble β-glucuronidase (GusA) enzyme properties through the formation of an artificially oligomeric state. First, a soluble CBD fused to the C-terminus of GusA (GusA-CBD) was obtained and characterized. Interestingly, the soluble GusA-CBD showed maximum activity at higher temperatures (65°C) and more acidic pH values (pH 6.0) than free GusA did (60°C and pH 7.5). Moreover, the GusA-CBD enzyme showed higher thermal and pH stabilities than the free GusA enzyme did. Additionally, GusA-CBD showed higher enzymatic activity in the presence of methanol than free GusA did. Evaluation of the protease accessibility of both enzymes revealed that GusA-CBD retained 100% of its activity after 1 h incubation in 0.5 mg/ml protease K, while free GusA completely lost its activity. Simple fusion of CBD as a single domain may be useful for tunable enzyme states to improve enzyme stability in industrial applications. PMID:28099480

  12. Fusion development and technology

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, D.B.

    1992-01-01

    This report discusses the following: superconducting magnet technology; high field superconductors; advanced magnetic system and divertor development; poloidal field coils; gyrotron development; commercial reactor studies--aries; ITER physics: alpha physics and alcator R D for ITER; lower hybrid current drive and heating in the ITER device; ITER superconducting PF scenario and magnet analysis; ITER systems studies; and safety, environmental and economic factors in fusion development.

  13. Sociodemographic risk, parenting, and effortful control: relations to salivary alpha-amylase and cortisol in early childhood.

    Science.gov (United States)

    Taylor, Zoe E; Spinrad, Tracy L; VanSchyndel, Sarah K; Eisenberg, Nancy; Huynh, Jacqueline; Sulik, Michael J; Granger, Douglas A

    2013-12-01

    Early sociodemographic risk, parenting, and temperament were examined as predictors of the activity of children's (N = 148; 81 boys, 67 girls) hypothalamic-pituitary-adrenal axis and autonomic nervous system. Demographic risk was assessed at 18 months (T1), intrusive/overcontrolling parenting and effortful control were assessed at 30 months (T2), and salivary cortisol and alpha-amylase were collected at 72 (T3) months of age. Demographic risk at T1 predicted lower levels of children's effortful control and higher levels of mothers' intrusive/overcontrolling parenting at T2. Intrusive/overcontrolling parenting at T2 predicted higher levels of children's cortisol and alpha-amylase at T3, but effortful control did not uniquely predict children's cortisol or alpha-amylase levels. Findings support the open nature of stress responsive physiological systems to influence by features of the early caregiving environment and underscore the utility of including measures of these systems in prevention trials designed to influence child outcomes by modifying parenting behavior. © 2012 Wiley Periodicals, Inc.

  14. Osteoclast Fusion

    DEFF Research Database (Denmark)

    Marie Julie Møller, Anaïs; Delaissé, Jean-Marie; Søe, Kent

    2017-01-01

    suggesting that fusion partners may specifically select each other and that heterogeneity between the partners seems to play a role. Therefore, we set out to directly test the hypothesis that fusion factors have a heterogenic involvement at different stages of nuclearity. Therefore, we have analyzed...... on the nuclearity of fusion partners. While CD47 promotes cell fusions involving mono-nucleated pre-osteoclasts, syncytin-1 promotes fusion of two multi-nucleated osteoclasts, but also reduces the number of fusions between mono-nucleated pre-osteoclasts. Furthermore, CD47 seems to mediate fusion mostly through......Investigations addressing the molecular keys of osteoclast fusion are primarily based on end-point analyses. No matter if investigations are performed in vivo or in vitro the impact of a given factor is predominantly analyzed by counting the number of multi-nucleated cells, the number of nuclei per...

  15. Viral dynamics and pharmacokinetics of peginterferon alpha-2a and peginterferon alpha-2b in naive patients with chronic hepatitis c: a randomized, controlled study.

    Science.gov (United States)

    Bruno, Raffaele; Sacchi, Paolo; Ciappina, Valentina; Zochetti, Cristina; Patruno, Savino; Maiocchi, Laura; Filice, Gaetano

    2004-08-01

    The two available pegylated interferon formulations, peginterferon alpha-2a and peginterferon alpha-2b, have different pharmacokinetic profiles; as a result they may have differing abilities to suppress the hepatitis C virus. A recently reported study by Formann and colleagues assessing early viral kinetics among 20 patients receiving peginterferon alpha-2b either once or twice weekly suggests that once-weekly administration of peginterferon alpha-2b is not sufficient for continuous exposure to interferon over 160 h. Twice-weekly administration is recommended to avoid increases in viral load as interferon levels decline prior to the end of the one-week dosing period. The objective of this study was to compare viral dynamics and pharmacokinetics between peginterferon alpha-2a and peginterferon alpha-2b in interferon-naive chronic hepatitis C patients. Patients were randomized to receive peginterferon alpha-2a 180 microg (n=10) or peginterferon alpha-2b 1.0 microg/kg (n=12) once weekly. Serum peginterferon concentrations were measured at baseline, 24, 48, 120 and 168h. Hepatitis C virus (HCV) RNA was measured at baseline, 24, 48, 120 and 168 h during week 1 and then at 4 and 12 weeks. Peginterferon alpha-2b achieved maximal serum levels at 24 h, and then decreased rapidly. Of the 12 patients who received peginterferon alpha-2b, no drug was detectable in seven (58%) patients at 120 h and in 11 (92%) at 168 h. In contrast, peginterferon alpha-2a concentrations increased continuously over time, reaching maximal serum levels from 48 to 168 h. Drug was detectable in all 10 patients at 168 h. At weeks 1 and 4 no significant difference was observed in mean HCV RNA between the groups. However, at week 12, mean HCV RNA was significantly lower in the peginterferon alpha-2a group versus the peginterferon alpha-2b group (2.8126 vs 3.8726; P<0.01). The differences in mean HCV RNA values at 12 weeks may be related to the different absorption and distribution profiles of the two

  16. Conceptual approach for an in-line quality control system in Additive Manufacturing Powder Bed Fusion processes

    Directory of Open Access Journals (Sweden)

    Fulga Simina

    2017-01-01

    Full Text Available Additive Manufacturing is one of the genuine hopes for the forth industrial revolution since digital data is controlling the whole layered production process. At the same time the geometric freedom and tool-free production assures a high degree of individualisation. But to be the driving force behind a new industrial revolution, a qualification of additive manufacturing processes is necessary so that the resulting products meet the required quality and safety standards in the different fields of application such as in handling technology or medical technology. This paper will discuss a conceptual approach for the development of an in-line quality control system in Additive Manufacturing Powder Bed Fusion processes using the example of the Selective Laser Sintering process.

  17. Redesign of a Variable-Gain Output Feedback Longitudinal Controller Flown on the High-Alpha Research Vehicle (HARV)

    Science.gov (United States)

    Ostroff, Aaron J.

    1998-01-01

    This paper describes a redesigned longitudinal controller that flew on the High-Alpha Research Vehicle (HARV) during calendar years (CY) 1995 and 1996. Linear models are developed for both the modified controller and a baseline controller that was flown in CY 1994. The modified controller was developed with three gain sets for flight evaluation, and several linear analysis results are shown comparing the gain sets. A Neal-Smith flying qualities analysis shows that performance for the low- and medium-gain sets is near the level 1 boundary, depending upon the bandwidth assumed, whereas the high-gain set indicates a sensitivity problem. A newly developed high-alpha Bode envelope criterion indicates that the control system gains may be slightly high, even for the low-gain set. A large motion-base simulator in the United Kingdom was used to evaluate the various controllers. Desired performance, which appeared to be satisfactory for flight, was generally met with both the low- and medium-gain sets. Both the high-gain set and the baseline controller were very sensitive, and it was easy to generate pilot-induced oscillation (PIO) in some of the target-tracking maneuvers. Flight target-tracking results varied from level 1 to level 3 and from no sensitivity to PIO. These results were related to pilot technique and whether actuator rate saturation was encountered.

  18. The Asfora Bullet Cage System Shows Comparable Fusion Rate Success Versus Control Cage in Posterior Lumbar Interbody Fusion in a Randomized Clinical Trial.

    Science.gov (United States)

    Morgan, Jeremy P; Miller, Ashley L; Thompson, Paul A; Asfora, Wilson T

    2016-04-01

    Low back pain and degeneration of the intervertebral disc are an integrated malady that affects millions of Americans. Cage devices used in association with posterior lumbar interbody fusion (PLIF) have been shown to be an effective approach in the treatment of a number of lower spine disorders attributed to degenerative disc disease (DDD). This study was undertaken as part of a U.S. Food and Drug Administration (FDA) Investigational Device Exemption (IDE) study and compares the effectiveness of the Asfora Bullet Cage System (ABCS) to successfully fuse vertebra at one or two levels between L2 and S1 in patients with DDD to an FDA approved comparison device, the Medtronic-Sofamor Danek Inter Fix Threaded Fusion Device (MSDIFD). A total of 257 randomized participants were implanted with either the ABCS device (n = 132) or the MSDIFD device (n = 125) through an open posterior approach using autogenous local bone graft without the use of pedicle screws. Patients were evaluated prior to surgery and at the 24 month (24-M) visit for fusion status, deep tendon reflex status, sensory function, motor function, straight leg raise status, pain, disability, and device safety. Radiological evaluation and statistical analysis were performed by independent professionals. Evaluation of device success was performed at 24-M visit. From the original group of 257 patients, 59 were lost to follow-up. Primary measures of success at the 24-M visit involved pain and function, fusion, neurological status, and device-related adverse events measures. Pain and function improved in both (MSDIFD: 75.7 percent; ABCS: 82.6 percent). Fusion success with all radiographic points at 24-M visits was 79.4 percent MSDIFD and 88.2 percent ABCS. Neurological improvement was seen in both (MSDIFD: 77.0 percent; ABCS: 87.8 percent). One device-related grade 1 adverse event was reported in the MSDIFD group. Disc height preservation was equivalent for single level fusions (MSDIFD: 16.1 percent; ABCS: 20

  19. Membrane fusion

    DEFF Research Database (Denmark)

    Bendix, Pól Martin

    2015-01-01

    At Stanford University, Boxer lab, I worked on membrane fusion of small unilamellar lipid vesicles to flat membranes tethered to glass surfaces. This geometry closely resembles biological systems in which liposomes fuse to plasma membranes. The fusion mechanism was studied using DNA zippering...... between complementary strands linked to the two apposing membranes closely mimicking the zippering mechanism of SNARE fusion complexes....

  20. Effective Control of Postprandial Glucose Level through Inhibition of Intestinal Alpha Glucosidase by Cymbopogon martinii (Roxb.

    Directory of Open Access Journals (Sweden)

    Varsha Ghadyale

    2012-01-01

    Full Text Available Inhibition of intestinal alpha glucosidase plays a major role in preventing rise in postprandial glucose level in diabetics. Cymbopogon martinii (CM (family Poaceae is used in traditional Indian medicine in treatment of diabetes mellitus. The alpha glucosidase inhibitory action of the plant is studied. The active component was separated using hot water extraction of the whole plant powder, differential solvent extraction, and silica gel column chromatography. The 30 : 70 toluene : ethyl acetate fraction showed optimum activity. The silica gel chromatography fraction demonstrated 98, 98, and 68% inhibition for starch, maltose, and sucrose, respectively, at 5 mg/kg body weight of rats. Intestinal absorption studies using noneverted intestinal sacs, as well as in vivo studies in streptozotocin-induced diabetic rats using oral glucose tolerance with maltose and sucrose load, revealed better inhibition of alpha glucosidase as compared to acarbose. Kinetic studies using Lineweaver Burk plot showed mixed to noncompetitive type of inhibition by CM. In vivo studies with maltose load of 2 mg and 3 mg/gm body weight showed a noncompetitive pattern of inhibition at 5 mg/kg body weight of CM as against 60 mg/kg body weight of acarbose. Thus CM is more effective alpha glucosidase inhibitor and at lower concentration than acarbose.

  1. Metal vapor micro-jet controls material redistribution in laser powder bed fusion additive manufacturing.

    Science.gov (United States)

    Ly, Sonny; Rubenchik, Alexander M; Khairallah, Saad A; Guss, Gabe; Matthews, Manyalibo J

    2017-06-22

    The results of detailed experiments and finite element modeling of metal micro-droplet motion associated with metal additive manufacturing (AM) processes are presented. Ultra high speed imaging of melt pool dynamics reveals that the dominant mechanism leading to micro-droplet ejection in a laser powder bed fusion AM is not from laser induced recoil pressure as is widely believed and found in laser welding processes, but rather from vapor driven entrainment of micro-particles by an ambient gas flow. The physics of droplet ejection under strong evaporative flow is described using simulations of the laser powder bed interactions to elucidate the experimental results. Hydrodynamic drag analysis is used to augment the single phase flow model and explain the entrainment phenomenon for 316 L stainless steel and Ti-6Al-4V powder layers. The relevance of vapor driven entrainment of metal micro-particles to similar fluid dynamic studies in other fields of science will be discussed.

  2. On the physical conditions for arising a controlled fusion chain reaction supported by neutrons in fusion facilities with magnetic plasma confinement

    Directory of Open Access Journals (Sweden)

    A.N. Shmelyov

    2015-11-01

    The fusion neutron source is considered to be the “richest”: neutron generation is accompanied by relatively small-scale processes. The thermonuclear facility with low neutron absorption blanket under consideration here could create a high density neutron flux in the blanket. It can be concluded from the above that such thermonuclear facilities could be used for fast transmutation of long-lived fission products with low neutron absorption cross-section, and perhaps even without their preliminary isotopic separation.

  3. Fusion rings and fusion ideals

    DEFF Research Database (Denmark)

    Andersen, Troels Bak

    by the so-called fusion ideals. The fusion rings of Wess-Zumino-Witten models have been widely studied and are well understood in terms of precise combinatorial descriptions and explicit generating sets of the fusion ideals. They also appear in another, more general, setting via tilting modules for quantum...

  4. Fusion neutronics

    CERN Document Server

    Wu, Yican

    2017-01-01

    This book provides a systematic and comprehensive introduction to fusion neutronics, covering all key topics from the fundamental theories and methodologies, as well as a wide range of fusion system designs and experiments. It is the first-ever book focusing on the subject of fusion neutronics research. Compared with other nuclear devices such as fission reactors and accelerators, fusion systems are normally characterized by their complex geometry and nuclear physics, which entail new challenges for neutronics such as complicated modeling, deep penetration, low simulation efficiency, multi-physics coupling, etc. The book focuses on the neutronics characteristics of fusion systems and introduces a series of theories and methodologies that were developed to address the challenges of fusion neutronics, and which have since been widely applied all over the world. Further, it introduces readers to neutronics design’s unique principles and procedures, experimental methodologies and technologies for fusion systems...

  5. Detection of {alpha} particles using semiconductors. Application to the control of plutonium extraction; Detection des particules {alpha} par semiconducteurs application au controle de l'extraction du plutonium

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-03-01

    A study is made of a particles produced by thick sources, using either diffused junction or surface barrier semiconductor detectors for controlling continuously the plutonium extraction process. For this, a presenting apparatus is described in which the solutions to be analyzed flow in contact with the detector protected by a thin mica membrane. A method is described which gives a precise recording of the spectra and which thus allows the separation of two or more {alpha} emitters present in the same solution. This method has been applied to the measurement of {sup 239}Pu in the the presence of {sup 241}Am with an accuracy of {+-}5 per cent. In the second part of the report is considered the detection of plutonium in solutions of {beta} - {gamma} emitting fission products. Pile-up is reduced by using a fast amplification chain associated to totally depleted thin detectors. Under these conditions a few mg of {sup 239}Pu can be detected in solutions of fission products having an activity of 100 curies/liter. A method is given for discriminating {alpha} and {beta} particles, it is based on the difference in the collection times for the charges liberated by these particles in the detector. (author) [French] On etudie la detection de particules {alpha} issues de sources epaisses par detecteurs semiconducteurs a jonction diffusee ou a barriere de surface pour le controle continu du procede d'extraction du plutonium. A cet effet on decrit un appareil presentateur dans lequel les solutions a analyser circulent au contact du detecteur protege par une membrane mince de mica. On decrit une methode qui permet par le trace precis des spectres de separer deux ou plusieurs emetteurs {alpha} presents dans une meme solution. Cette methode a ete appliquee a la mesure du {sup 239}Pu en presence de {sup 241}Am avec une precision de {+-} 5 pour cent. Dans la deuxieme partie on traite de la detection du plutonium dans des solutions de produits de fission emetteurs {beta} and {gamma

  6. Dust particles in controlled fusion devices: morphology, observations in the plasma and influence on the plasma performance

    Science.gov (United States)

    Rubel, M.; Cecconello, M.; Malmberg, J. A.; Sergienko, G.; Biel, W.; Drake, J. R.; Hedqvist, A.; Huber, A.; Philipps, V.

    2001-08-01

    The formation and release of particle agglomerates, i.e. debris and dusty objects, from plasma facing components and the impact of such materials on plasma operation in controlled fusion devices has been studied in the Extrap T2 reversed field pinch and the TEXTOR tokamak. Several plasma diagnostic techniques, camera observations and surface analysis methods were applied for in situ and ex situ investigation. The results are discussed in terms of processes that are decisive for dust transfer: localized power deposition connected with wall locked modes causing emission of carbon granules, brittle destruction of graphite and detachment of thick flaking co-deposited layers. The consequences for large next step devices are also addressed.

  7. Model-Based Control using Model and Mechanization Fusion Techniques for Image-Aided Navigation

    Science.gov (United States)

    2009-03-01

    sized helicopter, LQG control has also been utilized in controlling the same type of vehicle. Zhe Jiang, Jianda Han, Yuechao Wang , and Qi Song, from the...Han J. Wang Y., Z. and Q. Song. “Enhanced LQR Control for Unmanned Helicopter in Hover”. Proceedings of Systems and Control in Aerospace and As

  8. Sensor fusion and computer vision for context-aware control of a multi degree-of-freedom prosthesis

    Science.gov (United States)

    Markovic, Marko; Dosen, Strahinja; Popovic, Dejan; Graimann, Bernhard; Farina, Dario

    2015-12-01

    Objective. Myoelectric activity volitionally generated by the user is often used for controlling hand prostheses in order to replicate the synergistic actions of muscles in healthy humans during grasping. Muscle synergies in healthy humans are based on the integration of visual perception, heuristics and proprioception. Here, we demonstrate how sensor fusion that combines artificial vision and proprioceptive information with the high-level processing characteristics of biological systems can be effectively used in transradial prosthesis control. Approach. We developed a novel context- and user-aware prosthesis (CASP) controller integrating computer vision and inertial sensing with myoelectric activity in order to achieve semi-autonomous and reactive control of a prosthetic hand. The presented method semi-automatically provides simultaneous and proportional control of multiple degrees-of-freedom (DOFs), thus decreasing overall physical effort while retaining full user control. The system was compared against the major commercial state-of-the art myoelectric control system in ten able-bodied and one amputee subject. All subjects used transradial prosthesis with an active wrist to grasp objects typically associated with activities of daily living. Main results. The CASP significantly outperformed the myoelectric interface when controlling all of the prosthesis DOF. However, when tested with less complex prosthetic system (smaller number of DOF), the CASP was slower but resulted with reaching motions that contained less compensatory movements. Another important finding is that the CASP system required minimal user adaptation and training. Significance. The CASP constitutes a substantial improvement for the control of multi-DOF prostheses. The application of the CASP will have a significant impact when translated to real-life scenarious, particularly with respect to improving the usability and acceptance of highly complex systems (e.g., full prosthetic arms) by amputees.

  9. Damage of actively cooled plasma facing components of magnetic confinement controlled fusion machines

    Energy Technology Data Exchange (ETDEWEB)

    Chevet, G. [Association Euratom-CEA, DSM/DRFC, CEA Cadarache, Saint-Paul-Lez-Durance (France)], E-mail: gaelle.chevet@cea.fr; Schlosser, J. [Association Euratom-CEA, DSM/DRFC, CEA Cadarache, Saint-Paul-Lez-Durance (France); Martin, E.; Herb, V.; Camus, G. [Universite Bordeaux 1, UMR 5801 (CNRS-SAFRAN-CEA-UB1), Laboratoire des Composites Thermostructuraux, F-33600 Pessac (France)

    2009-03-31

    Plasma facing components (PFCs) of magnetic fusion machines have high manufactured residual stresses and have to withstand important stress ranges during operation. These actively cooled PFCs have a carbon fibre composite (CFC) armour and a copper alloy heat sink. Cracks mainly appear in the CFC near the composite/copper interface. In order to analyse damage mechanisms, it is important to well simulate the damage mechanisms both of the CFC and the CFC/Cu interface. This study focuses on the mechanical behaviour of the N11 material for which the scalar ONERA damage model was used. The damage parameters of this model were identified by similarity to a neighbour material, which was extensively analysed, according to the few characterization test results available for the N11. The finite elements calculations predict a high level of damage of the CFC at the interface zone explaining the encountered difficulties in the PFCs fabrication. These results suggest that the damage state of the CFC cells is correlated with a conductivity decrease to explain the temperature increase of the armour surface under fatigue heat load.

  10. Damage of actively cooled plasma facing components of magnetic confinement controlled fusion machines

    Science.gov (United States)

    Chevet, G.; Schlosser, J.; Martin, E.; Herb, V.; Camus, G.

    2009-03-01

    Plasma facing components (PFCs) of magnetic fusion machines have high manufactured residual stresses and have to withstand important stress ranges during operation. These actively cooled PFCs have a carbon fibre composite (CFC) armour and a copper alloy heat sink. Cracks mainly appear in the CFC near the composite/copper interface. In order to analyse damage mechanisms, it is important to well simulate the damage mechanisms both of the CFC and the CFC/Cu interface. This study focuses on the mechanical behaviour of the N11 material for which the scalar ONERA damage model was used. The damage parameters of this model were identified by similarity to a neighbour material, which was extensively analysed, according to the few characterization test results available for the N11. The finite elements calculations predict a high level of damage of the CFC at the interface zone explaining the encountered difficulties in the PFCs fabrication. These results suggest that the damage state of the CFC cells is correlated with a conductivity decrease to explain the temperature increase of the armour surface under fatigue heat load.

  11. Control of the risk of exposure to alpha emitting radionuclides in French nuclear power plants: example of Cattenom.

    Science.gov (United States)

    Le Guen, B; Roupioz, A; Rabu, B; Bouvy, A; Labouglie, J F; Garcier, Y

    2003-01-01

    Control of the risk of internal exposure of EDF PWR plant maintenance workers by alpha-emitting radioactive elements is based on identification and quantification of the contamination of the systems. In 2001, an experiment carried out at Cattenom Power Plant during a unit outage in the presence of a leaking fuel cladding, based on measurement of alpha-emitting radioactive elements, made it possible to determine a realistic particle resuspension coefficient. A resuspension coefficient of 10(-6) m(-1) was adopted for operational radiological protection. An appropriate monitoring system for workers was set in place in collaboration with the occupational medicine and radiological protection department. It was based on prior estimation of the level of alpha contamination, and confirmed by swipe measurements, atmospheric surveillance by monitors, and collective analysis by nose blow samples from workers selected on the basis of their workstations, as well as supplementary individual measurements (monitoring of faeces). This surveillance made it possible to validate an appropriate work area monitoring system.

  12. Alpha Thalassemia

    Science.gov (United States)

    Alpha Thalassemia Physicians often mistake alpha thalassemia trait for iron deficiency anemia and incorrectly prescribe iron supplements that have no effect 1 on the anemia. αα αα Normal alpha ...

  13. The vaccinia virus 14-kilodalton (A27L) fusion protein forms a triple coiled-coil structure and interacts with the 21-kilodalton (A17L) virus membrane protein through a C-terminal alpha-helix.

    Science.gov (United States)

    Vázquez, M I; Rivas, G; Cregut, D; Serrano, L; Esteban, M

    1998-12-01

    The vaccinia virus 14-kDa protein (encoded by the A27L gene) plays an important role in the biology of the virus, acting in virus-to-cell and cell-to-cell fusions. The protein is located on the surface of the intracellular mature virus form and is essential for both the release of extracellular enveloped virus from the cells and virus spread. Sequence analysis predicts the existence of four regions in this protein: a structureless region from amino acids 1 to 28, a helical region from residues 29 to 37, a triple coiled-coil helical region from residues 44 to 72, and a Leu zipper motif at the C terminus. Circular dichroism spectroscopy, analytical ultracentrifugation, and chemical cross-linking studies of the purified wild-type protein and several mutant forms, lacking one or more of the above regions or with point mutations, support the above-described structural division of the 14-kDa protein. The two contiguous cysteine residues at positions 71 and 72 are not responsible for the formation of 14-kDa protein trimers. The location of hydrophobic residues at the a and d positions on a helical wheel and of charged amino acids in adjacent positions, e and g, suggests that the hydrophobic and ionic interactions in the triple coiled-coil helical region are involved in oligomer formation. This conjecture was supported by the construction of a three-helix bundle model and molecular dynamics. Binding assays with purified proteins expressed in Escherichia coli and cytoplasmic extracts from cells infected with a virus that does not produce the 14-kDa protein during infection (VVindA27L) show that the 21-kDa protein (encoded by the A17L gene) is the specific viral binding partner and identify the putative Leu zipper, the predicted third alpha-helix on the C terminus of the 14-kDa protein, as the region involved in protein binding. These findings were confirmed in vivo, following transfection of animal cells with plasmid vectors expressing mutant forms of the 14-kDa protein and

  14. Sensor data fusion for body state estimation in a bipedal robot and its feedback control application for stable walking.

    Science.gov (United States)

    Chen, Ching-Pei; Chen, Jing-Yi; Huang, Chun-Kai; Lu, Jau-Ching; Lin, Pei-Chun

    2015-02-27

    We report on a sensor data fusion algorithm via an extended Kalman filter for estimating the spatial motion of a bipedal robot. Through fusing the sensory information from joint encoders, a 6-axis inertial measurement unit and a 2-axis inclinometer, the robot's body state at a specific fixed position can be yielded. This position is also equal to the CoM when the robot is in the standing posture suggested by the detailed CAD model of the robot. In addition, this body state is further utilized to provide sensory information for feedback control on a bipedal robot with walking gait. The overall control strategy includes the proposed body state estimator as well as the damping controller, which regulates the body position state of the robot in real-time based on instant and historical position tracking errors. Moreover, a posture corrector for reducing unwanted torque during motion is addressed. The body state estimator and the feedback control structure are implemented in a child-size bipedal robot and the performance is experimentally evaluated.

  15. Sensor Data Fusion for Body State Estimation in a Bipedal Robot and Its Feedback Control Application for Stable Walking

    Directory of Open Access Journals (Sweden)

    Ching-Pei Chen

    2015-02-01

    Full Text Available We report on a sensor data fusion algorithm via an extended Kalman filter for estimating the spatial motion of a bipedal robot. Through fusing the sensory information from joint encoders, a 6-axis inertial measurement unit and a 2-axis inclinometer, the robot’s body state at a specific fixed position can be yielded. This position is also equal to the CoM when the robot is in the standing posture suggested by the detailed CAD model of the robot. In addition, this body state is further utilized to provide sensory information for feedback control on a bipedal robot with walking gait. The overall control strategy includes the proposed body state estimator as well as the damping controller, which regulates the body position state of the robot in real-time based on instant and historical position tracking errors. Moreover, a posture corrector for reducing unwanted torque during motion is addressed. The body state estimator and the feedback control structure are implemented in a child-size bipedal robot and the performance is experimentally evaluated.

  16. Distributed computer control system in the Nova Laser Fusion Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    1985-09-01

    The EE Technical Review has two purposes - to inform readers of various activities within the Electronics Engineering Department and to promote the exchange of ideas. The articles, by design, are brief summaries of EE work. The articles included in this report are as follows: Overview - Nova Control System; Centralized Computer-Based Controls for the Nova Laser Facility; Nova Pulse-Power Control System; Nova Laser Alignment Control System; Nova Beam Diagnostic System; Nova Target-Diagnostics Control System; and Nova Shot Scheduler. The 7 papers are individually abstracted.

  17. On the theory of MHD modes driven by strong ExB velocity shear in tokamaks. Addendum. 2000 Plasma Phys. Control. Fusion 42 57

    Energy Technology Data Exchange (ETDEWEB)

    Mikhailovskii, A.B.; Sharapov, S.E.; Timofeev, A.V. [JET Joint Undertaking, Abingdon, Oxfordshire OX14 3EA (United Kingdom)

    2000-07-01

    The theory of MHD modes driven by strong ExB velocity shear in tokamaks given by Mikhailovskii and Sharapov (2000 Plasma Phys. Control. Fusion 42 57) is revised. It is suggested that, in the approximations taken by these authors, there are no MHD eigenmodes if the cross-field velocity shear is larger then the Alfven frequency shear. (author)

  18. Cold nuclear fusion

    Directory of Open Access Journals (Sweden)

    Huang Zhenqiang Huang Yuxiang

    2013-10-01

    Full Text Available In normal temperature condition, the nuclear force constraint inertial guidance method, realize the combination of deuterium and tritium, helium and lithium... And with a magnetic moment of light nuclei controlled cold nuclear collide fusion, belongs to the nuclear energy research and development in the field of applied technology "cold nuclear collide fusion". According to the similarity of the nuclear force constraint inertial guidance system, the different velocity and energy of the ion beam mixing control, developed ion speed dc transformer, it is cold nuclear fusion collide, issue of motivation and the nuclear power plant start-up fusion and power transfer system of the important equipment, so the merger to apply for a patent

  19. EURATOM-CEA association contributions to the 26. EPS conference on controlled fusion and plasma physics, Maastricht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-10-15

    This report references the EURATOM-CEA association contributions presented at the 26. EPS conference on controlled fusion and plasma physics, in Maastricht (Netherlands) the 14-18 June 1999. Two invited papers and 24 contributed papers are proposed. They deal with: tokamak devices; particle recirculation in ergodic divertor; current profile control and MHD stability in Tore Supra discharges; edge-plasma control by the ergodic divertor; electron heat transport in stochastic magnetic layer; bolometry and radiated power; particle collection by ergodic divertor; study and simulation of pa impurities; line shape modelling for plasma edge conditions; dynamical study of the radial structure of the fluctuations measured by reciprocating Langmuir probe in Tore Supra; up-down asymmetry of density fluctuations; Halo currents in a circular tokamak; real time measurement of the position, density, profile and current profile at Tore Supra; poloidal rotation measurement by reflectometry; interpretation of q-profile dependence of the LH power deposition profile during LHCD experiments; ICFR plasma production and optimization; improved core electron confinement; measurement of hard X-ray emission profile; modelling of shear effects on thermal and particles transport; ion turbulence; current drive generation based on autoresonance and intermittent trapping mechanisms. (A.L.B.)

  20. Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestion.

    Science.gov (United States)

    Fitches, Elaine; Edwards, Martin G; Mee, Christopher; Grishin, Eugene; Gatehouse, Angharad M R; Edwards, John P; Gatehouse, John A

    2004-01-01

    The mannose-specific snowdrop lectin (Galanthus nivalis agglutinin: GNA), when fed to insects, binds to the gut epithelium and passes into the haemolymph. The ability of GNA to act as a carrier protein to deliver an insecticidal spider venom neurotoxin (Segestria florentina toxin 1: SFI1) to the haemolymph of lepidopteran larvae was investigated. Constructs encoding SFI1 and an SFI1/GNA fusion protein were expressed in Pichia pastoris. The insecticidal activity of purified recombinant proteins on injection was found to be comparable to published values for SfI1 purified from spider venom [Toxicon 40 (2002) 125]. Whereas neither GNA nor SFI1 alone showed acute toxicity when fed to larvae of tomato moth (Lacanobia oleracea), feeding SFI1/GNA fusion at 2.5% of dietary proteins was insecticidal to first stadium larvae, causing 100% mortality after 6 days. The protein also showed a significant, dose dependent, toxicity towards fourth and fifth stadium larvae, with growth reduced by up to approximately 90% over a 4-day assay period compared to controls. Delivery of intact SFI1/GNA to the haemolymph in these insects was shown by western blotting; haemolymph samples from fusion-fed larvae contained a GNA-immunoreactive protein of the same molecular weight as the SFI1/GNA fusion. SFI1/GNA and similar fusion proteins offer a novel and effective approach for delivering haemolymph active toxins by oral administration, which could be used in crop protection by expression in transgenic plants.

  1. Cervical total disc replacement is superior to anterior cervical decompression and fusion: a meta-analysis of prospective randomized controlled trials.

    Directory of Open Access Journals (Sweden)

    Yujie Zhang

    Full Text Available Despite being considered the standard surgical procedure for symptomatic cervical disc disease, anterior cervical decompression and fusion invariably accelerates adjacent segment degeneration. Cervical total disc replacement is a motion-preserving procedure developed as a substitute to fusion. Whether cervical total disc replacement is superior to fusion remains unclear.We comprehensively searched PubMed, EMBASE, Medline, and the Cochrane Library in accordance with the inclusion criteria to identify possible studies. The retrieved results were last updated on December 12, 2014. We classified the studies as short-term and midterm follow-up.Nineteen randomized controlled trials involving 4516 cases were identified. Compared with anterior cervical decompression and fusion, cervical total disc replacement had better functional outcomes (neck disability index [NDI], NDI success, neurological success, neck pain scores reported on a numerical rating scale [NRS], visual analog scales scores and overall success, greater segmental motion at the index level, fewer adverse events and fewer secondary surgical procedures at the index and adjacent levels in short-term follow-up (P 0.05.Cervical total disc replacement presented favorable functional outcomes, fewer adverse events, and fewer secondary surgical procedures. The efficacy and safety of cervical total disc replacement are superior to those of fusion. Longer-term, multicenter studies are required for a better evaluation of the long-term efficacy and safety of the two procedures.

  2. alpha-Adrenergic control of intestinal circulation in heat-stressed baboons.

    Science.gov (United States)

    Proppe, D W

    1980-05-01

    The mechanisms involved in producing intestinal vasoconstriction during a hyperthermia-producing intestinal vasoconstriction during a hyperthermia-producing environmental heat stress are unknown. Five conscious baboons (Papio anubis), each with chronically implanted catheters and a flow probe around the superior mesenteric artery, were subjected to environmental heating (Ta 40-45 degrees C) to raise their arterial blood temperature (Tbl) 2.0-2.6 degrees C to approximately 39.5 degrees C. Accompanying the gradual rise in Tbl was a fall in mean superior mesenteric artery blood flow (MSMF) and a progressive rise in superior mesenteric vascular resistance (SMR). At peak Tbl, MSMF had fallen 28.8 +/- 0.6% (mean +/- SE) and SMR had risen 50.2 +/- 4.2%. To determine the involvement of the sympathetic nervous system in producing this intestinal vasoconstriction, the baboon was subjected to environmental heating after induction of alpha-adrenergic receptor blockade by phenoxybenzamine or phentolamine. In this state, the rise in Tbl was accompanied by no change in MSMF and a slight, but not statistically significant, rise (7.8 +/- 3.8%) in SMR. Since alpha-receptor blockade nearly completely abolishes intestinal vasoconstriction during heat stress, this intestinal vasoconstriction must be mediated primarily by elevated sympathetic outflow.

  3. Analysis and control of proteolysis of a fusion protein in Pichia pastoris fed-batch processes.

    Science.gov (United States)

    Jahic, Mehmedalija; Gustavsson, Malin; Jansen, Ann-Katrin; Martinelle, Mats; Enfors, Sven-Olof

    2003-04-10

    A fusion protein composed of a cellulose-binding module (CBM) from Neocallimastix patriciarum cellulase 6A and lipase B from Candida antarctica (CALB), was produced by Pichia pastoris Mut(+) in high-cell density bioreactor cultures. The production was induced by switching from growth on glycerol to growth on methanol. The lipase activity in the culture supernatant increased at an almost constant rate up to a value corresponding to 1.3 g x l(-1) of CBM-CALB. However, only about 40% of the product was of full-length according to Western blot analysis. This loss was due to a cleavage of the protein in the linker between the CBM and the CALB moieties. The cleavage was catalyzed by serine proteases in the culture supernatant. The CALB-moiety was subjected to further slow degradation by cell-associated proteolysis. Different strategies were used to reduce the proteolysis. Previous efforts to shorten the linker region resulted in a stable protein but with ten times reduced product concentration in bioreactor cultures (Gustavsson et al. 2001, Protein Eng. 14, 711-715). Addition of rich medium for protease substrate competition had no effect on the proteolysis of CBM-CALB. The kinetics for the proteolytic reactions, with and without presence of cells were shown to be influenced by pH. The fastest reaction, cleavage in the linker, was substantially reduced at pH values below 5.0. Decreasing the pH from 5.0 to 4.0 in bioreactor cultures resulted in an increase of the fraction of full-length product from 40 to 90%. Further improvement was achieved by decreasing the temperature from 30 to 22 degrees C during the methanol feed phase. By combining the optimal pH and the low temperature almost all product (1.5 g x l(-1)) was obtained as full-length protein with a considerably higher purity in the culture supernatant compared with the original cultivation.

  4. Different slopes for different folks: alpha and delta EEG power predict subsequent video game learning rate and improvements in cognitive control tasks.

    Science.gov (United States)

    Mathewson, Kyle E; Basak, Chandramallika; Maclin, Edward L; Low, Kathy A; Boot, Walter R; Kramer, Arthur F; Fabiani, Monica; Gratton, Gabriele

    2012-12-01

    We hypothesized that control processes, as measured using electrophysiological (EEG) variables, influence the rate of learning of complex tasks. Specifically, we measured alpha power, event-related spectral perturbations (ERSPs), and event-related brain potentials during early training of the Space Fortress task, and correlated these measures with subsequent learning rate and performance in transfer tasks. Once initial score was partialled out, the best predictors were frontal alpha power and alpha and delta ERSPs, but not P300. By combining these predictors, we could explain about 50% of the learning rate variance and 10%-20% of the variance in transfer to other tasks using only pretraining EEG measures. Thus, control processes, as indexed by alpha and delta EEG oscillations, can predict learning and skill improvements. The results are of potential use to optimize training regimes. Copyright © 2012 Society for Psychophysiological Research.

  5. Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.

    Science.gov (United States)

    Núñez, Vanessa; Alameda, Daniel; Rico, Daniel; Mota, Rubén; Gonzalo, Pilar; Cedenilla, Marta; Fischer, Thierry; Boscá, Lisardo; Glass, Christopher K; Arroyo, Alicia G; Ricote, Mercedes

    2010-06-01

    The retinoid X receptor alpha (RXRalpha) plays a central role in the regulation of many intracellular receptor signaling pathways and can mediate ligand-dependent transcription by forming homodimers or heterodimers with other nuclear receptors. Although several members of the nuclear hormone receptor superfamily have emerged as important regulators of macrophage gene expression, the existence in vivo of an RXR signaling pathway in macrophages has not been established. Here, we provide evidence that RXRalpha regulates the transcription of the chemokines Ccl6 and Ccl9 in macrophages independently of heterodimeric partners. Mice lacking RXRalpha in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis. These studies demonstrate that macrophage RXRalpha plays key roles in the regulation of innate immunity and represents a potential target for immunotherapy of sepsis.

  6. Monitoring and Control of Urban Critical Infrastructures: A Novel Approach to System Design and Data Fusion

    Directory of Open Access Journals (Sweden)

    Mario La Manna

    2015-02-01

    Full Text Available The monitoring and control of urban critical infrastructures consists of the protection of assets such as houses, offices, government and private buildings, with low cost, high quality and high dependability. In order to satisfy all these requirements at the same time, the control of a number of assets has to be performed by means of automated systems based on networks of heterogeneous sensors. This new concept idea is based on the use of unmanned operations at each of the many remote assets (each asset is monitored through a network of sensors and a man-in-the-loop automated control in a central site (Operational Center, which performs alarm detection and system management.

  7. A Fusion of Sensors Information for Autonomous Driving Control of an Electric Vehicle (EV)

    Science.gov (United States)

    Haris, Hasri; Wan, Khairunizam; Hazry, D.; Razlan, Zuradzman M.

    2013-12-01

    The study uses the environment of the road as input variables for the main system to control steering wheel, brake and acceleration pedals. A camera is installed on the roof of the Electric Vehicles (EV) and is used to obtain image information of the road. On the other hand, users or drivers do not have to directly contact with the main system because it will autonomously control the devices by using fuzzy information of the road conditions. A fuzzy information means in the preliminary experiments, reasoning of the various environments will be done by using fuzzy approach. At the end of the study, several existing algorithms for controlling motors and image processing technique could be combined into an algorithm that could be used to move EV without assist from human.

  8. Applying the data fusion method to evaluation of the performance of two control signals in monitoring polarization mode dispersion effects in fiber optic links

    Science.gov (United States)

    Dashtbani Moghari, M.; Rezaei, P.; Habibalahi, A.

    2015-02-01

    With increasing distance and bit rate in fiber optic links the effects of polarization mode dispersion (PMD) have been highlighted. Since PMD has a statistical nature, using a control signal that can provide accurate information to dynamically tune a PMD compensator is of great importance. In this paper, we apply the data fusion method with the aim of introducing a method that can be used to evaluate more accurately the performance of control signals before applying them in a PMD compensation system. Firstly, the minimum and average degree of polarization (DOP_min and DOP_ave respectively) as control signals in monitoring differential group delay (DGD) for a system including all-order PMD are calculated. Then, features including the amounts of sensitivity and ambiguity in DGD monitoring are calculated for NRZ data format as DGD to bit time (DGD/T) varies. It is shown that each of the control signals mentioned has both positive and negative features for efficient DGD monitoring. Therefore, in order to evaluate features concurrently and increase reliability, we employ data fusion to fuse features of each control signal, which makes evaluating and predicting the performance of control signals possible, before applying them in a real PMD compensation system. Finally, the reliability of the results obtained from data fusion is tested in a typical PMD compensator.

  9. Measurements of escaping alphas in the TFTR DT experiments

    Energy Technology Data Exchange (ETDEWEB)

    Zweben, S.J.; Darrow, D.S.; Herrmann, H.W.

    1995-03-01

    Alpha particle loss to the wall of TFTR has been measured during the initial TFTR DT run period. These measurements were made with the same lost alpha scintillator detector system used previously for DD fusion products, except for a switch of the scintillator material from zinc sulfide (P31) to yttrium aluminate (P46) to insure a linear response up to the maximum alpha flux expected in DT. The alpha loss signals in DT are {approx} 100 times larger than the DD fusion product loss signals, as expected from the neutron rates and the relative sensitivity to DT vs. DD fusion products.

  10. Evaluation of salivary tumor necrosis factor-alpha in patients with the chronic periodontitis: A case-control study

    Directory of Open Access Journals (Sweden)

    Hojatollah Yousefimanesh

    2013-01-01

    Full Text Available Context: Periodontitis is a chronic infectious disease that leads to inflammation of the tissues supporting the teeth, bone loss, attachment loss progressively. In chronic periodontitis for starting the host response and inflammatory reaction, the presence of the infectious agent is necessary. Aims: One of inflammatory factors is tumor necrosis factor-alpha (TNF-α that appear to be important in the destruction of periodontal tissues that were examined in this study. Materials and Methods: This study was performed in the laboratory and case-control study. The samples of study collected from 30 individuals with chronic periodontitis and 30 healthy controls that matched for age and sex, together. Unstimulated saliva samples were collected from patients and then TNF-α level were measured by enzyme-linked immunosorbent assay and were compared with the control group. Statistical Analysis Used: In this study for statistical analysis, Mann-Whitney was used. Results: There were differences in mean salivary concentrations of TNF-α in controls and patients. The average concentration in the case group was 9.1 (pg/ml and the control group was 8.7 (pg/ml, but there was no significant difference between case and control groups (P > 0.05. Conclusions: The results of this analysis showed no significant relationship between two groups TNF-α concentration.This biomarker can not seem to be a good index to evaluate or predict periodontal disease.

  11. Alpha heating in toroidal devices

    Energy Technology Data Exchange (ETDEWEB)

    Miley, G.H.

    1978-01-01

    Ignition (or near-ignition) by alpha heating is a key objective for the achievement of economic fusion reactors. While good confinement of high-energy alphas appears possible in larger reactors, near-term tokamak-type ignition experiments as well as some concepts for small reactors (e.g., the Field-Reversed Mirror or FRM) potentially face marginal situations. Consequently, there is a strong motivation to develop methods to evaluate alpha losses and heating profiles in some detail. Such studies for a TFTR-size tokamak and for a small FRM are described here.

  12. Robust EMG sensing system based on data fusion for myoelectric control of a robotic arm

    OpenAIRE

    2009-01-01

    Abstract Background Myoelectric control of a robotic manipulator may be disturbed by failures due to disconnected electrodes, interface impedance changes caused by movements, problems in the recording channel and other various noise sources. To correct these problems, this paper presents two fusing techniques, Variance Weighted Average (VWA) and Decentralized Kalman Filter (DKF), both based on the myoelectric signal variance as selecting criterion. Methods Tested in five volunteers, a redunda...

  13. Anticipatory Monitoring and Control of Complex Systems using a Fuzzy based Fusion of Support Vector Regressors

    Energy Technology Data Exchange (ETDEWEB)

    Miltiadis Alamaniotis; Vivek Agarwal

    2014-10-01

    This paper places itself in the realm of anticipatory systems and envisions monitoring and control methods being capable of making predictions over system critical parameters. Anticipatory systems allow intelligent control of complex systems by predicting their future state. In the current work, an intelligent model aimed at implementing anticipatory monitoring and control in energy industry is presented and tested. More particularly, a set of support vector regressors (SVRs) are trained using both historical and observed data. The trained SVRs are used to predict the future value of the system based on current operational system parameter. The predicted values are then inputted to a fuzzy logic based module where the values are fused to obtain a single value, i.e., final system output prediction. The methodology is tested on real turbine degradation datasets. The outcome of the approach presented in this paper highlights the superiority over single support vector regressors. In addition, it is shown that appropriate selection of fuzzy sets and fuzzy rules plays an important role in improving system performance.

  14. Two decades of progress in understanding and control of laser plasma instabilities in indirect drive inertial fusion

    Science.gov (United States)

    Montgomery, David S.

    2016-05-01

    Our understanding of laser-plasma instability (LPI) physics has improved dramatically over the past two decades through advancements in experimental techniques, diagnostics, and theoretical and modeling approaches. We have progressed from single-beam experiments—ns pulses with ˜kJ energy incident on hundred-micron-scale target plasmas with ˜keV electron temperatures—to ones involving nearly 2 MJ energy in 192 beams onto multi-mm-scale plasmas with temperatures ˜4 keV. At the same time, we have also been able to use smaller-scale laser facilities to substantially improve our understanding of LPI physics and evaluate novel approaches to their control. These efforts have led to a change in paradigm for LPI research, ushering in an era of engineering LPI to accomplish specific objectives, from tuning capsule implosion symmetry to fixing nonlinear saturation of LPI processes at acceptable levels to enable the exploration of high energy density physics in novel plasma regimes. A tutorial is provided that reviews the progress in the field from the vantage of the foundational LPI experimental results. The pedagogical framework of the simplest models of LPI will be employed, but attention will also be paid to settings where more sophisticated models are needed to understand the observations. Prospects for the application of our improved understanding for inertial fusion (both indirect- and direct-drive) and other applications will also be discussed.

  15. MHD Stability Analysis and Flow Controls of Liquid Metal Free Surface Film Flows as Fusion Reactor PFCs

    Science.gov (United States)

    Zhang, Xiujie; Pan, Chuanjie; Xu, Zengyu

    2016-12-01

    Numerical and experimental investigation results on the magnetohydrodynamics (MHD) film flows along flat and curved bottom surfaces are summarized in this study. A simplified modeling has been developed to study the liquid metal MHD film state, which has been validated by the existing experimental results. Numerical results on how the inlet velocity (V), the chute width (W) and the inlet film thickness (d0) affect the MHD film flow state are obtained. MHD stability analysis results are also provided in this study. The results show that strong magnetic fields make the stable V decrease several times compared to the case with no magnetic field, especially small radial magnetic fields (Bn) will have a significant impact on the MHD film flow state. Based on the above numerical and MHD stability analysis results flow control methods are proposed for flat and curved MHD film flows. For curved film flow we firstly proposed a new multi-layers MHD film flow system with a solid metal mesh to get the stable MHD film flows along the curved bottom surface. Experiments on flat and curved MHD film flows are also carried out and some firstly observed results are achieved. supported by the National Magnetic Confinement Fusion Science Program of China (Nos. 2014GB125003 and 2013GB114002), National Natural Science Foundation of China (No. 11105044)

  16. Biologically-inspired robust and adaptive multi-sensor fusion and active control

    Science.gov (United States)

    Khosla, Deepak; Dow, Paul A.; Huber, David J.

    2009-04-01

    In this paper, we describe a method and system for robust and efficient goal-oriented active control of a machine (e.g., robot) based on processing, hierarchical spatial understanding, representation and memory of multimodal sensory inputs. This work assumes that a high-level plan or goal is known a priori or is provided by an operator interface, which translates into an overall perceptual processing strategy for the machine. Its analogy to the human brain is the download of plans and decisions from the pre-frontal cortex into various perceptual working memories as a perceptual plan that then guides the sensory data collection and processing. For example, a goal might be to look for specific colored objects in a scene while also looking for specific sound sources. This paper combines three key ideas and methods into a single closed-loop active control system. (1) Use high-level plan or goal to determine and prioritize spatial locations or waypoints (targets) in multimodal sensory space; (2) collect/store information about these spatial locations at the appropriate hierarchy and representation in a spatial working memory. This includes invariant learning of these spatial representations and how to convert between them; and (3) execute actions based on ordered retrieval of these spatial locations from hierarchical spatial working memory and using the "right" level of representation that can efficiently translate into motor actions. In its most specific form, the active control is described for a vision system (such as a pantilt- zoom camera system mounted on a robotic head and neck unit) which finds and then fixates on high saliency visual objects. We also describe the approach where the goal is to turn towards and sequentially foveate on salient multimodal cues that include both visual and auditory inputs.

  17. International Space Station alpha remote manipulator system workstation controls test report

    Science.gov (United States)

    Ehrenstrom, William A.; Swaney, Colin; Forrester, Patrick

    1994-01-01

    Previous development testing for the space station remote manipulator system workstation controls determined the need for hardware controls for the emergency stop, brakes on/off, and some camera functions. This report documents the results of an evaluation to further determine control implementation requirements, requested by the Canadian Space Agency (CSA), to close outstanding review item discrepancies. This test was conducted at the Johnson Space Center's Space Station Mockup and Trainer Facility in Houston, Texas, with nine NASA astronauts and one CSA astronaut as operators. This test evaluated camera iris and focus, back-up drive, latching end effector release, and autosequence controls using several types of hardware and software implementations. Recommendations resulting from the testing included providing guarded hardware buttons to prevent accidental actuation, providing autosequence controls and back-up drive controls on a dedicated hardware control panel, and that 'latch on/latch off', or on-screen software, controls not be considered. Generally, the operators preferred hardware controls although other control implementations were acceptable. The results of this evaluation will be used along with further testing to define specific requirements for the workstation design.

  18. pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion.

    Science.gov (United States)

    Desai, Tanay M; Marin, Mariana; Mason, Caleb; Melikyan, Gregory B

    2017-05-12

    Enveloped viruses infect host cells by fusing their membranes with those of the host cell, a process mediated by viral glycoproteins upon binding to cognate host receptors or entering into acidic intracellular compartments. Whereas the effect of receptor density on viral infection has been well studied, the role of cell type-specific factors/processes, such as pH regulation, has not been characterized in sufficient detail. Here, we examined the effects of cell-extrinsic factors (buffer environment) and cell-intrinsic factors (interferon-inducible transmembrane proteins, IFITMs), on the pH regulation in early endosomes and on the efficiency of acid-dependent fusion of the avian sarcoma and leukosis virus (ASLV), with endosomes. First, we found that a modest elevation of external pH can raise the pH in early endosomes in a cell type-dependent manner and thereby delay the acid-induced fusion of endocytosed ASLV. Second, we observed a cell type-dependent delay between the low pH-dependent and temperature-dependent steps of viral fusion, consistent with the delayed enlargement of the fusion pore. Third, ectopic expression of IFITMs, known to potently block influenza virus fusion with late compartments, was found to only partially inhibit ASLV fusion with early endosomes. Interestingly, IFITM expression promoted virus uptake and the acidification of endosomal compartments, resulting in an accelerated fusion rate when driven by the glycosylphosphatidylinositol-anchored, but not by the transmembrane isoform of the ASLV receptor. Collectively, these results highlight the role of cell-extrinsic and cell-intrinsic factors in regulating the efficiency and kinetics of virus entry and fusion with target cells. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  19. Peaceful Uses of Fusion

    Science.gov (United States)

    Teller, E.

    1958-07-03

    Applications of thermonuclear energy for peaceful and constructive purposes are surveyed. Developments and problems in the release and control of fusion energy are reviewed. It is pointed out that the future of thermonuclear power reactors will depend upon the construction of a machine that produces more electric energy than it consumes. The fuel for thermonuclear reactors is cheap and practically inexhaustible. Thermonuclear reactors produce less dangerous radioactive materials than fission reactors and, when once brought under control, are not as likely to be subject to dangerous excursions. The interaction of the hot plasma with magnetic fields opens the way for the direct production of electricity. It is possible that explosive fusion energy released underground may be harnessed for the production of electricity before the same feat is accomplished in controlled fusion processes. Applications of underground detonations of fission devices in mining and for the enhancement of oil flow in large low-specific-yield formations are also suggested.

  20. Drosophila Erect wing (Ewg) controls mitochondrial fusion during muscle growth and maintenance by regulation of the Opa1-like gene.

    Science.gov (United States)

    Rai, Mamta; Katti, Prasanna; Nongthomba, Upendra

    2014-01-01

    Mitochondrial biogenesis and morphological changes are associated with tissue-specific functional demand, but the factors and pathways that regulate these processes have not been completely identified. A lack of mitochondrial fusion has been implicated in various developmental and pathological defects. The spatiotemporal regulation of mitochondrial fusion in a tissue such as muscle is not well understood. Here, we show in Drosophila indirect flight muscles (IFMs) that the nuclear-encoded mitochondrial inner membrane fusion gene, Opa1-like, is regulated in a spatiotemporal fashion by the transcription factor/co-activator Erect wing (Ewg). In IFMs null for Ewg, mitochondria undergo mitophagy and/or autophagy accompanied by reduced mitochondrial functioning and muscle degeneration. By following the dynamics of mitochondrial growth and shape in IFMs, we found that mitochondria grow extensively and fuse during late pupal development to form the large tubular mitochondria. Our evidence shows that Ewg expression during early IFM development is sufficient to upregulate Opa1-like, which itself is a requisite for both late pupal mitochondrial fusion and muscle maintenance. Concomitantly, by knocking down Opa1-like during early muscle development, we show that it is important for mitochondrial fusion, muscle differentiation and muscle organization. However, knocking down Opa1-like, after the expression window of Ewg did not cause mitochondrial or muscle defects. This study identifies a mechanism by which mitochondrial fusion is regulated spatiotemporally by Ewg through Opa1-like during IFM differentiation and growth.

  1. New ALPHA-2 magnet

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    On 21 June, members of the ALPHA collaboration celebrated the handover of the first solenoid designed for the ALPHA-2 experiment. The magnet has since been successfully installed and is working well.   Khalid Mansoor, Sumera Yamin and Jeffrey Hangst in front of the new ALPHA-2 solenoid. “This was the first of three identical solenoids that will be installed between now and September, as the rest of the ALPHA-2 device is installed and commissioned,” explains ALPHA spokesperson Jeffrey Hangst. “These magnets are designed to allow us to transfer particles - antiprotons, electrons and positrons - between various parts of the new ALPHA-2 device by controlling the transverse size of the particle bunch that is being transferred.” Sumera Yamin and Khalid Mansoor, two Pakistani scientists from the National Centre for Physics in Islamabad, came to CERN in February specifically to design and manufacture these magnets. “We had the chance to work on act...

  2. Buffett’s Alpha

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Kabiller, David; Heje Pedersen, Lasse

    Berkshire Hathaway has realized a Sharpe ratio of 0.76, higher than any other stock or mutual fund with a history of more than 30 years, and Berkshire has a significant alpha to traditional risk factors. However, we find that the alpha becomes insignificant when controlling for exposures to Betting...

  3. Cold fusion

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Suk Yong; Sung, Ki Woong; Kang, Joo Sang; Lee, Jong Jik [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-02-01

    So called `cold fusion phenomena` are not confirmed yet. Excess heat generation is very delicate one. Neutron generation is most reliable results, however, the records are erratic and the same results could not be repeated. So there is no reason to exclude the malfunction of testing instruments. The same arguments arise in recording {sup 4}He, {sup 3}He, {sup 3}H, which are not rich in quantity basically. An experiment where plenty of {sup 4}He were recorded is attached in appendix. The problem is that we are trying to search cold fusion which is permitted by nature or not. The famous tunneling effect in quantum mechanics will answer it, however, the most fusion rate is known to be negligible. The focus of this project is on the theme that how to increase that negligible fusion rate. 6 figs, 4 tabs, 1512 refs. (Author).

  4. Spinal Fusion

    Science.gov (United States)

    ... results in predictable healing. Autograft is currently the “gold standard” source of bone for a fusion. The ... pump. With this technique, the patient presses a button that delivers a predetermined amount of narcotic pain ...

  5. Heavy ion beam propagation through a gas-filled chamber for inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Barboza, Nigel Oswald [Univ. of California, Berkeley, CA (United States)

    1996-10-01

    The work presented here evaluates the dynamics of a beam of heavy ions propagating through a chamber filled with gas. The motivation for this research stems from the possibility of using heavy ion beams as a driver in inertial confinement fusion reactors for the purpose of generating electricity. Such a study is important in determining the constraints on the beam which limit its focus to the small radius necessary for the ignition of thermonuclear microexplosions which are the source of fusion energy. Nuclear fusion is the process of combining light nuclei to form heavier ones. One possible fusion reaction combines two isotopes of hydrogen, deuterium and tritium, to form an alpha particle and a neutron, with an accompanying release of ~17.6 MeV of energy. Generating electricity from fusion requires that we create such reactions in an efficient and controlled fashion, and harness the resulting energy. In the inertial confinement fusion (ICF) approach to energy production, a small spherical target, a few millimeters in radius, of deuterium and tritium fuel is compressed so that the density and temperature of the fuel are high enough, ~200 g/cm3 and ~20 keV, that a substantial number of fusion reactions occur; the pellet microexplosion typically releases ~350 MJ of energy in optimized power plant scenarios.

  6. Heavy ion beam propagation through a gas-filled chamber for inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Barboza, N.O.

    1996-10-01

    The work presented here evaluates the dynamics of a beam of heavy ions propagating through a chamber filled with gas. The motivation for this research stems from the possibility of using heavy ion beams as a driver in inertial confinement fusion reactors for the purpose of generating electricity. Such a study is important in determining the constraints on the beam which limit its focus to the small radius necessary for the ignition of thermonuclear microexplosions which are the source of fusion energy. Nuclear fusion is the process of combining light nuclei to form heavier ones. One possible fusion reaction combines two isotopes of hydrogen, deuterium and tritium, to form an alpha particle and a neutron, with an accompanying release of {approximately}17.6 MeV of energy. Generating electricity from fusion requires that we create such reactions in an efficient and controlled fashion, and harness the resulting energy. In the inertial confinement fusion (ICF) approach to energy production, a small spherical target, a few millimeters in radius, of deuterium and tritium fuel is compressed so that the density and temperature of the fuel are high enough, {approximately}200 g/cm{sup 3} and {approximately}20 keV, that a substantial number of fusion reactions occur; the pellet microexplosion typically releases {approximately}350 MJ of energy in optimized power plant scenarios.

  7. Thalamic gap junctions control local neuronal synchrony and influence macroscopic oscillation amplitude during EEG alpha rhythms

    Directory of Open Access Journals (Sweden)

    Stuart eHughes

    2011-08-01

    Full Text Available Although EEG alpha ( (8-13 Hz rhythms are often considered to reflect an ‘idling’ brain state, numerous studies indicate that they are also related to many aspects of perception. Recently, we outlined a potential cellular substrate by which such aspects of perception might be linked to basic  rhythm mechanisms. This scheme relies on a specialized subset of rhythmically bursting thalamocortical (TC neurons (high-threshold bursting cells in the lateral geniculate nucleus (LGN which are interconnected by gap junctions (GJs. By engaging GABAergic interneurons, that in turn inhibit conventional relay-mode TC neurons, these cells can lead to an effective temporal framing of thalamic relay-mode output. Although the role of GJs is pivotal in this scheme, evidence for their involvement in thalamic  rhythms has thus far mainly derived from experiments in in vitro slice preparations. In addition, direct anatomical evidence of neuronal GJs in the LGN is currently lacking. To address the first of these issues we tested the effects of the GJ inhibitors, carbenoxolone (CBX and 18-glycyrrhetinic acid (18-GA, given directly to the LGN via reverse microdialysis, on spontaneous LGN and EEG  rhythms in behaving cats. We also examined the effect of CBX on  rhythm-related LGN unit activity. Indicative of a role for thalamic GJs in these activities, 18-GA and CBX reversibly suppressed both LGN and EEG  rhythms, with CBX also decreasing neuronal synchrony. To address the second point, we used electron microscopy to obtain definitive ultrastructural evidence for the presence of GJs between neurons in the cat LGN. As interneurons show no phenotypic evidence of GJ coupling (i.e. dye-coupling and spikelets we conclude that these GJs must belong to TC neurons. The potential significance of these findings for relating macroscopic changes in  rhythms to basic cellular processes is discussed.

  8. Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.

    Directory of Open Access Journals (Sweden)

    Marc Liesa

    Full Text Available BACKGROUND: There is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression. METHODOLOGY/PRINCIPAL FINDINGS: Here, we demonstrate that reduced mitochondrial size observed in knock-out mice for the transcriptional regulator PGC-1beta is associated with a selective reduction in Mitofusin 2 (Mfn2 expression, a mitochondrial fusion protein. This decrease in Mfn2 is specific since expression of the remaining components of mitochondrial fusion and fission machinery were not affected. Furthermore, PGC-1beta increases mitochondrial fusion and elongates mitochondrial tubules. This PGC-1beta-induced elongation specifically requires Mfn2 as this process is absent in Mfn2-ablated cells. Finally, we show that PGC-1beta increases Mfn2 promoter activity and transcription by coactivating the nuclear receptor Estrogen Related Receptor alpha (ERRalpha. CONCLUSIONS/SIGNIFICANCE: Taken together, our data reveal a novel mechanism by which mammalian cells control mitochondrial fusion. In addition, we describe a novel role of PGC-1beta in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2.

  9. Synthetic report 2012. Research programme on controlled thermonuclear fusion; Rapport de synthèse 2012. Programme de recherche Fusion thermonucléaire contrôlée

    Energy Technology Data Exchange (ETDEWEB)

    Vaucher, C. [Secrétariat à l’éducation et à la recherche (SER), Berne (Switzerland); Tran, M. Q.; Villard, L. [Swiss Federal Institute of Technology EPFL, Lausanne (Switzerland); Marot, L. [University of Basel, Basel (Switzerland)

    2013-07-01

    Since 1961, Switzerland participates in the research on thermonuclear fusion thanks to the creation of the Research Centre in Plasma Physics. In 1979 it entered into partnership with the European programme on fusion through its adhesion to EURATOM. The thermonuclear fusion is an interesting energy source because the basic fuel is practically inexhaustible and its use does not release any significant CO{sub 2} quantity and very little radioactive residues. But its working up faces enormous physical and technological difficulties. The International Thermonuclear Reactor (ITER), presently in construction, has to demonstrate the technological feasibility of the controlled fusion. Il will be followed by DEMO, foreseen for 2040-2050, which must guarantee the economical rentability. At CRPP the research projects are partitioned onto several sites: at the Swiss Federal Institute of Technology (EPFL) in Lausanne, they concern the physics of the magnetic confinement with the Variable Geometry Tokamak (TCV), the development of theoretical models and the numerical simulation, the plasma heating and the generation of hyper frequency waves; the Paul Scherrer Institute (PSI) studies the superconductivity and the materials; the interactions between the plasma and the Tokamak walls are studied at the Basel University for the structures of ITER. Thanks to its large flexibility, TCV allows the creation and the control of plasmas of very different forms. The injection system of millimetric waves allows orienting the injected power according to specific profiles. By using the asymmetry of the flow in the toroidal sense, the plasma rotation could be measured with a much better accuracy than before. In TCV, by playing on the form of the plasma, it was possible to strongly reduce the energy quantity which is expelled by the Edge Localized Modes (ELM) onto the wall of the vacuum chamber. The ‘snowflake’ configuration created in TCV allows distributing the ELM energy onto several impact

  10. Real-time imaging of HIF-1alpha stabilization and degradation.

    Directory of Open Access Journals (Sweden)

    Ekaterina Moroz

    Full Text Available HIF-1alpha is overexpressed in many human cancers compared to normal tissues due to the interaction of a multiplicity of factors and pathways that reflect specific genetic alterations and extracellular stimuli. We developed two HIF-1alpha chimeric reporter systems, HIF-1alpha/FLuc and HIF-1alpha(DeltaODDD/FLuc, to investigate the tightly controlled level of HIF-1alpha protein in normal (NIH3T3 and HEK293 and glioma (U87 cells. These reporter systems provided an opportunity to investigate the degradation of HIF-1alpha in different cell lines, both in culture and in xenografts. Using immunofluorescence microscopy, we observed different patterns of subcellular localization of HIF-1alpha/FLuc fusion protein between normal cells and cancer cells; similar differences were observed for HIF-1alpha in non-transduced, wild-type cells. A dynamic cytoplasmic-nuclear exchange of the fusion protein and HIF-1alpha was observed in NIH3T3 and HEK293 cells under different conditions (normoxia, CoCl2 treatment and hypoxia. In contrast, U87 cells showed a more persistent nuclear localization pattern that was less affected by different growing conditions. Employing a kinetic model for protein degradation, we were able to distinguish two components of HIF-1alpha/FLuc protein degradation and quantify the half-life of HIF-1alpha fusion proteins. The rapid clearance component (t(1/2 approximately 4-6 min was abolished by the hypoxia-mimetic CoCl2 MG132 treatment and deletion of ODD domain, and reflects the oxygen/VHL-dependent degradation pathway. The slow clearance component (t(1/2 approximately 200 min is consistent with other unidentified non-oxygen/VHL-dependent degradation pathways. Overall, the continuous bioluminescence readout of HIF-1alpha/FLuc stabilization in vitro and in vivo will facilitate the development and validation of therapeutics that affect the stability and accumulation of HIF-1alpha.

  11. Coordinated alpha and gamma control of muscles and spindles in movement and posture

    OpenAIRE

    Si eLi; Cheng eZhuang; Manzhao eHao; Xin eHe; Juan Carlos eMarquez Ruiz; Chuanxin Minos Niu; Ning eLan

    2015-01-01

    Mounting evidence suggests that both α and γ motoneurons are active during movement and posture, but how does the central motor system coordinate the α-γ controls in these tasks remains sketchy due to lack of in vivo data. Here a computational model of α-γ control of muscles and spindles was used to investigate α-γ integration and coordination for movement and posture. The model comprised physiologically realistic spinal circuitry, muscles, proprioceptors, and skeletal biomechanics. In the mo...

  12. Doping-control analysis of the 5alpha-reductase inhibitor finasteride: determination of its influence on urinary steroid profiles and detection of its major urinary metabolite.

    Science.gov (United States)

    Thevis, Mario; Geyer, Hans; Mareck, Ute; Flenker, Ulrich; Schänzer, Wilhelm

    2007-04-01

    5alpha-Reductase inhibitors such as finasteride are prohibited in sports according to the World Anti-Doping Agency. This class of drugs is used therapeutically to treat benign prostatic hyperplasia, as well as male baldness, by decreasing 5alpha-reductase activity. Accordingly, metabolic pathways of endogenous as well as synthetic steroids are influenced, which complicates the evaluation of steroid profiles in sports drug testing. The possibility of manipulating steroid excretion profiles and, presumably, to mask steroid abuse was investigated in 5 administration studies with use of finasteride at different doses, with and without coadministration of 19-norandrostenedione. The evaluation of urinary steroid profiles demonstrated the intense effect of finasteride on numerous crucial analytical parameters, in particular the production of 5alpha-steroids such as androsterone and 5alpha-androstane-3alpha,17beta-diol, which was significantly reduced. In addition, the excretion of the main metabolite of norandrostenedione, norandrosterone, was significantly suppressed, by up to 84%, in elimination studies. For doping-control analysis the use of 5alpha-reductase inhibitors causes considerable problems because steroid profile parameters, which are commonly considered stable, are highly affected and complicate the detection of steroid abuse. In addition, the suppression of production and renal excretion of 5alpha-steroids such as 19-norandrosterone generated from anabolic agents such as 19-norandrostenedione may lead to false-negative doping-control results, because urine specimens are reported positive only when a threshold level of 2 ng/mL is exceeded. Finally, a method for the determination of the major urinary metabolite of finasteride (carboxy-finasteride) in routine doping-control screening with use of liquid chromatography-tandem mass spectrometry is described, allowing the detection of carboxy-finasteride for up to 94 hours in urine specimens collected after an oral

  13. Clinical and radiographic analysis of cervical disc arthroplasty compared with allograft fusion: a randomized controlled clinical trial.

    Science.gov (United States)

    Mummaneni, Praveen V; Burkus, J Kenneth; Haid, Regis W; Traynelis, Vincent C; Zdeblick, Thomas A

    2007-03-01

    The authors report the results of a prospective randomized multicenter study in which the results of cervical disc arthroplasty were compared with anterior cervical discectomy and fusion (ACDF) in patients treated for symptomatic single-level cervical degenerative disc disease (DDD). Five hundred forty-one patients with single-level cervical DDD and radiculopathy were enrolled at 32 sites and randomly assigned to one of two treatment groups: 276 patients in the investigational group underwent anterior cervical discectomy and decompression and arthroplasty with the PRESTIGE ST Cervical Disc System (Medtronic Sofamor Danek); 265 patients in the control group underwent decompressive ACDF. Eighty percent of the arthroplasty-treated patients (223 of 276) and 75% of the control patients (198 of 265) completed clinical and radiographic follow-up examinations at routine intervals for 2 years after surgery. Analysis of all currently available postoperative 12- and 24-month data indicated a two-point greater improvement in the neck disability index score in the investigational group than the control group. The arthroplasty group also had a statistically significant higher rate of neurological success (p = 0.005) as well as a lower rate of secondary revision surgeries (p = 0.0277) and supplemental fixation (p = 0.0031). The mean improvement in the 36-Item Short Form Health Survey Physical Component Summary scores was greater in the investigational group at 12 and 24 months, as was relief of neck pain. The patients in the investigational group returned to work 16 days sooner than those in the control group, and the rate of adjacent-segment reoperation was significantly lower in the investigational group as well (p = 0.0492, log-rank test). The cervical disc implant maintained segmental sagittal angular motion averaging more than 7 degrees. In the investigational group, there were no cases of implant failure or migration. The PRESTIGE ST Cervical Disc System maintained

  14. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation.

    Science.gov (United States)

    Chen, Xiwu; Abair, Tristin D; Ibanez, Maria R; Su, Yan; Frey, Mark R; Dise, Rebecca S; Polk, D Brent; Singh, Amar B; Harris, Raymond C; Zent, Roy; Pozzi, Ambra

    2007-05-01

    Integrins control many cell functions, including generation of reactive oxygen species (ROS) and regulation of collagen synthesis. Mesangial cells, found in the glomerulus of the kidney, are able to produce large amounts of ROS via the NADPH oxidase. We previously demonstrated that integrin alpha1-null mice develop worse fibrosis than wild-type mice following glomerular injury and this is due, in part, to excessive ROS production by alpha1-null mesangial cells. In the present studies, we describe the mechanism whereby integrin alpha1-null mesangial cells produce excessive ROS. Integrin alpha1-null mesangial cells have constitutively increased basal levels of activated Rac1, which result in its increased translocation to the cell membrane, excessive ROS production, and consequent collagen IV deposition. Basal Rac1 activation is a direct consequence of ligand-independent increased epidermal growth factor receptor (EGFR) phosphorylation in alpha1-null mesangial cells. Thus, our study demonstrates that integrin alpha1beta1-EGFR cross talk is a key step in negatively regulating Rac1 activation, ROS production, and excessive collagen synthesis, which is a hallmark of diseases characterized by irreversible fibrosis.

  15. Effect of phorbol ester on 6-keto PGF sup 1. alpha. production in aorta from control-salt and aldosterone-salt hypertensive rats

    Energy Technology Data Exchange (ETDEWEB)

    Jones, S.B.; Jones, A.W. (Univ. of Missouri, Columbia (United States))

    1991-03-11

    The authors have previously shown that norepinephrine (NE) stimulated 6-keto-PGF{sub 1{alpha}} and thromboxane B{sub 2}(TXB{sub 2}) production in aorta from control-salt (CSR) and aldosterone-salt hypertensive rats (AHR) through the alpha-1 adrenoceptor (A1AR). While there was no difference in NE-stimulated TXB{sub 2} production between CSR and AHR, 6-keto-PGF{sub 1{alpha}} production was attenuated in aorta from AHR compared tissues. The authors were interested in whether the source of the arachidonic acid (AA) metabolites was through direct coupling of the A1AR and PLA{sub 2} or secondary to activation of PLC. One approach to answering this question was to bypass the receptor and activate protein kinase-C (PKC) directly. PMA caused a time-dependent increase in both 6-keto-PGF{sub 1{alpha}} and TXB{sub 2}. The time course was much slower than NE-stimulated production of these metabolites, but the pattern was similar with TXB{sub 2} appearing before 6-keto-PGF{sub 1{alpha}}. The PMA concentration-response curves for 6-keto-PGF{sub 1{alpha}} production for CSR and AHR were nearly superimposable. Staurosporine inhibited PMA stimulated 6-keto-PGF{sub 1{alpha}} production in CSR and AHR with nearly equal potency. Thus, while activation of PKC results in increases in AA metabolites, alterations in this pathway do not appear to be responsible for the differences observed with NE-stimulated 6-keto-PGF{sub 1{alpha}} production. These data support the concept of direct coupling between the A1AR and PLA{sub 2} in vascular smooth muscle.

  16. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density

    DEFF Research Database (Denmark)

    Barres, Romain; Osler, Megan E; Yan, Jie;

    2009-01-01

    -CpG nucleotides. Non-CpG methylation was acutely increased in human myotubes by exposure to tumor necrosis factor-alpha (TNF-alpha) or free fatty acids, but not insulin or glucose. Selective silencing of the DNA methyltransferase 3B (DNMT3B), but not DNMT1 or DNMT3A, prevented palmitate-induced non......-CpG methylation of PGC-1alpha and decreased mtDNA and PGC-1alpha mRNA. We provide evidence for PGC-1alpha hypermethylation, concomitant with reduced mitochondrial content in type 2 diabetic patients, and link DNMT3B to the acute fatty-acid-induced non-CpG methylation of PGC-1alpha promoter....

  17. Controlled alpha-sexithiophene nanostructure formation in standard and inverted configuration organic solar cells

    DEFF Research Database (Denmark)

    Radziwon, Michal Jędrzej; Goszczak, Arkadiusz Jaroslaw; Fernandes Cauduro, André Luis;

    accepting C60 layers, solar cell configurations. Furthermore, a comparative study of the correlation between the α-6T morphology and device performance parameters for standard and inverted solar cell configurations is presented. The morphology of the α 6T layer is controlled by means of the substrate...... temperature during low rate (nanostructures at higher temperatures. Optical and atomic force microscopy is conducted together...

  18. A novel method for controlled synthesis of nanosized hematite ({alpha}-Fe{sub 2}O{sub 3}) thin film on liquid-vapor interface

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Pawan [Jaypee University of Information Technology (India); Singh, Raj Kumar [CSIR-Indian Institute of Petroleum (India); Rawat, Nitin [Gwangju Institute of Science and Technology (Korea, Republic of); Barman, Partha Bir [Jaypee University of Information Technology (India); Katyal, Subhash Chander [Jaypee Institute of Information Technology (India); Jang, Hwanchol; Lee, Heung-No, E-mail: heungno@gist.ac.kr [Gwangju Institute of Science and Technology (Korea, Republic of); Kumar, Rajesh, E-mail: rajesh.kumar@juit.ac.in [Jaypee University of Information Technology (India)

    2013-04-15

    Hematite ({alpha}-Fe{sub 2}O{sub 3}) films with a high quality surface morphology have been formed at the liquid-vapor interface using a novel approach. The surface morphology/size of the nanoparticles constituting the film is tuned in a controlled manner. It is observed that the concentration of polyvinyl alcohol in the precursor Fe{sup 3+}/Fe{sup 2+} solution, the concentration of ammonia (NH{sub 3}) vapor, and the annealing temperature are factors influencing the surface morphology/size of nanoparticles. The diameter of the {alpha}-Fe{sub 2}O{sub 3} nanoparticles inside the film is controlled to be 2-15 nm by varying the synthesis conditions, and accordingly the films have roughness in the 1.34-6.8 nm range. The prepared {alpha}-Fe{sub 2}O{sub 3} films are crystalline in nature and exhibit superparamagnetic behavior at room temperature.

  19. Trophoblast fusion.

    Science.gov (United States)

    Huppertz, Berthold; Gauster, Martin

    2011-01-01

    The villous trophoblast of the human placenta is the epithelial cover of the fetal chorionic villi floating in maternal blood. This epithelial cover is organized in two distinct layers, the multinucleated syncytiotrophoblast directly facing maternal blood and a second layer of mononucleated cytotrophoblasts. During pregnancy single cytotrophoblasts continuously fuse with the overlying syncytiotrophoblast to preserve this end-differentiated layer until delivery. Syncytial fusion continuously supplies the syncytiotrophoblast with compounds of fusing cytotrophoblasts such as proteins, nucleic acids and lipids as well as organelles. At the same time the input of cytotrophoblastic components is counterbalanced by a continuous release of apoptotic material from the syncytiotrophoblast into maternal blood. Fusion is an essential step in maintaining the syncytiotrophoblast. Trophoblast fusion was shown to be dependant on and regulated by multiple factors such as fusion proteins, proteases and cytoskeletal proteins as well as cytokines, hormones and transcription factors. In this chapter we focus on factors that may be involved in the fusion process of trophoblast directly or that may prepare the cytotrophoblast to fuse.

  20. CORA—a control program for the ROMA on-line alpha detection apparatus

    Science.gov (United States)

    Taut, Steffen; Hübener, S.

    2002-07-01

    This paper reports on the new control program CORA for the ROMA detection device. It was developed as part of the HITGAS apparatus for the study of seaborgium ( Z=106) as oxide hydroxide. CORA runs under Win9x and Win NT. It is object oriented, programmed with Borland C++ Builder. Its main features are high flexibility for various experiment modes, hardware independence to a large extent, and an easy-to-understand user interface.

  1. Diffusion and interface controlled reactions in {alpha}-(Cu-Al-Ag) alloys

    Energy Technology Data Exchange (ETDEWEB)

    Adorno, A.T. [Instituto de Quimica, Unesp, Departamento de Fisico-Quimica, Caixa Postal 355, 14801-970 Araraquara, SP (Brazil)]. E-mail: atadorno@iq.unesp.br; Silva, R.A.G. [Instituto de Quimica, Unesp, Departamento de Fisico-Quimica, Caixa Postal 355, 14801-970 Araraquara, SP (Brazil); Magdalena, A.G. [Instituto de Quimica, Unesp, Departamento de Fisico-Quimica, Caixa Postal 355, 14801-970 Araraquara, SP (Brazil)

    2007-08-30

    The isothermal kinetics of Ag precipitation was studied in Cu-Al-Ag alloys with concentrations ranging from 2 to 8 wt.%Al and 2 to 12 wt.%Ag, using scanning electron microscopy (SEM), X-ray energy dispersive spectroscopy (EDX) and microhardness measurements. The results indicated a change in the precipitates growing mechanism from diffusion to interface controlled process, probably due to a change in the nature of the interface with the Ag and Al enrichment of the precipitates.

  2. Probing of incomplete fusion dynamics by spin-distribution measurement

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Pushpendra P. [Accelerator Laboratory, Department of Physics, A.M. University, Aligarh (UP) 202002 (India); NP Group, Inter-University Accelerator Center, PO Box 10502, New Delhi 110067 (India)], E-mail: pushpendrapsingh@gmail.com; Singh, B.P. [Accelerator Laboratory, Department of Physics, A.M. University, Aligarh (UP) 202002 (India)], E-mail: bpsinghamu@gmail.com; Sharma, M.K.; Gupta, Unnati [Accelerator Laboratory, Department of Physics, A.M. University, Aligarh (UP) 202002 (India); Kumar, Rakesh [NP Group, Inter-University Accelerator Center, PO Box 10502, New Delhi 110067 (India); Singh, D. [Accelerator Laboratory, Department of Physics, A.M. University, Aligarh (UP) 202002 (India); Singh, R.P.; Murlithar, S. [NP Group, Inter-University Accelerator Center, PO Box 10502, New Delhi 110067 (India); Ansari, M.A.; Prasad, R. [Accelerator Laboratory, Department of Physics, A.M. University, Aligarh (UP) 202002 (India); Bhowmik, R.K. [NP Group, Inter-University Accelerator Center, PO Box 10502, New Delhi 110067 (India)], E-mail: ranjan@iuac.ernet.in

    2009-01-12

    Aiming to probe incomplete fusion dynamics in {sup 16}O + {sup 169}Tm system, spin-distributions of various reaction products populated via xn-, {alpha}/2{alpha}xn-channels have been measured at E{approx}5.6MeV/nucleon. Prompt {gamma}-rays in coincidence with fast charged particles (Z=1,2) have been recorded to achieve the information about involved reaction processes on the basis of their experimentally observed spin-populations during de-excitation. The experimentally observed spin-distributions for direct-{alpha}-emitting channels (associated with incomplete fusion) have been found to be distinctly different than that observed for fusion-evaporation (complete fusion) channels. The mean value of driving input angular momenta associated with various direct-{alpha}/2{alpha}xn-channels have been found to be higher than that observed for fusion-evaporation xn/{alpha}xn-channels, and increases with direct-{alpha}-multiplicity in forward cone. Experimentally measured, normalized production yields of fusion-evaporation xn/{alpha}xn-channels have been found to be in good agreement with the predictions of theoretical model code PACE4. Further, in order to understand the feeding probability in both complete and incomplete fusion reaction products, an attempt has been made to generate feeding intensity profiles from spin-distribution data. It has been observed that the complete fusion products are strongly fed over a broad spin range, while incomplete fusion products are found to be less fed and/or the population of lower spin states are strongly hindered.

  3. Fusion Machinery

    DEFF Research Database (Denmark)

    Sørensen, Jakob Balslev; Milosevic, Ira

    2015-01-01

    the vesicular SNARE VAMP2/synaptobrevin-2 and the target (plasma membrane) SNAREs SNAP25 and syntaxin-1 results in fusion and release of neurotransmitter, synchronized to the electrical activity of the cell by calcium influx and binding to synaptotagmin. Formation of the SNARE complex is tightly regulated...... and appears to start with syntaxin-1 bound to an SM (Sec1/Munc18-like) protein. Proteins of the Munc13-family are responsible for opening up syntaxin and allowing sequential binding of SNAP-25 and VAMP2/synaptobrevin-2. N- to C-terminal “zippering” of the SNARE domains leads to membrane fusion...

  4. Fusion Propulsion Study

    Science.gov (United States)

    1989-07-01

    of propellant can be millions of times greater than the fuel, only a tiny fraction can completely push out the fuel. If the plasma is moving at a... push -plate for various explosive yields. It appears that the maximum specific impulse for such a system is -4000 to 5000 sec and increasing the base...Energy Agency, 1977, p. 507. Bourque, R.F., "OHTE as a Fusion Reactor," Proc. 4th Topl. Mt,. Tecnology of Controlled NV?4clear Fusion, King of Prussia

  5. Two-plasmid vector system for independently controlled expression of green and red fluorescent fusion proteins in Staphylococcus aureus.

    Science.gov (United States)

    Brzoska, Anthony J; Firth, Neville

    2013-05-01

    We have constructed a system for the regulated coexpression of green fluorescent protein (GFP) and red fluorescent protein (RFP) fusions in Staphylococcus aureus. It was validated by simultaneous localization of cell division proteins FtsZ and Noc and used to detect filament formation by an actin-like ParM plasmid partitioning protein in its native coccoid host.

  6. Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis.

    Science.gov (United States)

    Caviglia, Sara; Brankatschk, Marko; Fischer, Elisabeth J; Eaton, Suzanne; Luschnig, Stefan

    2016-07-01

    A crucial yet ill-defined step during the development of tubular networks, such as the vasculature, is the formation of connections (anastomoses) between pre-existing lumenized tubes. By studying tracheal tube anastomosis in Drosophila melanogaster, we uncovered a key role of secretory lysosome-related organelle (LRO) trafficking in lumen fusion. We identified the conserved calcium-binding protein Unc-13-4/Staccato (Stac) and the GTPase Rab39 as critical regulators of this process. Stac and Rab39 accumulate on dynamic vesicles, which form exclusively in fusion tip cells, move in a dynein-dependent manner, and contain late-endosomal, lysosomal, and SNARE components characteristic of LROs. The GTPase Arl3 is necessary and sufficient for Stac LRO formation and promotes Stac-dependent intracellular fusion of juxtaposed apical plasma membranes, thereby forming a transcellular lumen. Concomitantly, calcium is released locally from ER exit sites and apical membrane-associated calcium increases. We propose that calcium-dependent focused activation of LRO exocytosis restricts lumen fusion to appropriate domains within tip cells.

  7. Alpha-enolase (ENO1 controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis

    Directory of Open Access Journals (Sweden)

    Moitza Principe

    2017-01-01

    Full Text Available Abstract Background We have previously shown that in pancreatic ductal adenocarcinoma (PDA cells, the glycolytic enzyme alpha-enolase (ENO1 also acts as a plasminogen receptor and promotes invasion and metastasis formation. Moreover, ENO1 silencing in PDA cells induces oxidative stress, senescence and profoundly modifies PDA cell metabolism. Although anti-ENO1 antibody inhibits PDA cell migration and invasion, little is known about the role of ENO1 in regulating cell-cell and cell-matrix contacts. We therefore investigated the effect of ENO1 silencing on the modulation of cell morphology, adhesion to matrix substrates, cell invasiveness, and metastatic ability. Methods The membrane and cytoskeleton modifications that occurred in ENO1-silenced (shENO1 PDA cells were investigated by a combination of confocal microscopy and atomic force microscopy (AFM. The effect of ENO1 silencing was then evaluated by phenotypic and functional experiments to identify the role of ENO1 in adhesion, migration, and invasion, as well as in senescence and apoptosis. The experimental results were then validated in a mouse model. Results We observed a significant increase in the roughness of the cell membrane due to ENO1 silencing, a feature associated with an impaired ability to migrate and invade, along with a significant downregulation of proteins involved in cell-cell and cell-matrix adhesion, including alpha v/beta 3 integrin in shENO1 PDA cells. These changes impaired the ability of shENO1 cells to adhere to Collagen I and IV and Fibronectin and caused an increase in RGD-independent adhesion to vitronectin (VN via urokinase plasminogen activator receptor (uPAR. Binding of uPAR to VN triggers integrin-mediated signals, which result in ERK1-2 and RAC activation, accumulation of ROS, and senescence. In shENO1 cancer cells, the use of an anti-uPAR antibody caused significant reduction of ROS production and senescence. Overall, a decrease of in vitro and in vivo cell

  8. Venous responses during exercise in rainbow trout, Oncorhynchus mykiss : [alpha]-adrenergic control and the antihypotensive function of the renin-angiotensin system

    DEFF Research Database (Denmark)

    Sandblom, E.; Axelsson, M.; McKenzie, David

    2006-01-01

    ) was investigated during exercise after [alpha]-adrenoceptor blockade. Fish were subjected to a 20-min exercise challenge at 0.66 body lengths s-1 (BL s-1) while Pven, dorsal aortic blood pressure (Pda) and relative cardiac output (Q) was recorded continuously. Heart rate (fH), cardiac stroke volume (SV) and total......The role of the [alpha]-adrenergic system in the control of cardiac preload (central venous blood pressure; Pven) and venous capacitance during exercise was investigated in rainbow trout (Oncorhynchus mykiss). In addition, the antihypotensive effect of the renin-angiotesin system (RAS...... systemic resistance (Rsys) were derived from these variables. The mean circulatory filling pressure (MCFP) was measured at rest and at the end of the exercise challenge, to investigate potential exercise-mediated changes in venous capacitance. The protocol was repeated after [alpha]-adrenoceptor blockade...

  9. Is there a need for cervical collar usage post anterior cervical decompression and fusion using interbody cages? A randomized controlled pilot trial.

    Science.gov (United States)

    Abbott, Allan; Halvorsen, Marie; Dedering, Asa

    2013-05-01

    Anterior cervical discectomy and fusion (ACDF) is a common surgical intervention for radiculopathy resulting from degenerative cervical spine conditions. Post-surgical cervical collar use is believed to reduce post-operative pain, provide the patient with a sense of security during activities of daily living and even reduce rates of non-fusion. This prospective randomized controlled pilot trial investigates trial design feasibility in relation to prospective physical, functional, and quality of life-related outcomes of patients undergoing ACDF with interbody cage, with (n = 17) and without (n = 16) post-operative cervical collar usage. Results show that the sample provides sufficient statistical power to show that the use of a rigid cervical collar during 6 post-operative weeks is associated with significantly lower levels of neck disability index after 6 weeks and significantly lower levels of prospective neck pain. To investigate causal quality of life or fusion rate outcomes, sample size needs to be increased at least fourfold and optimally sixfold when accounting for data loss in prospective follow-up. The study suggests that post-surgical cervical collar usage may help certain patients cope with initial post-operative pain and disability.

  10. Control of yeast mating signal transduction by a mammalian. beta. sub 2 -adrenergic receptor and G sub s. alpha. subunit

    Energy Technology Data Exchange (ETDEWEB)

    King, K.; Caron, M.G.; Lefkowitz, R.J. (Duke Univ. Medical Center, Durham, NC (USA)); Dohlman, H.G.; Thorner, J. (Univ. of California, Berkeley (USA))

    1990-10-05

    To facilitate functional and mechanistic studies of receptor-G protein interactions by expression of the human {beta}{sub 2}-adrenergic receptor (h{beta}-AR) has been expressed in Saccharomyces cerevisiae. This was achieved by placing a modified h{beta}-AR gene under control of the galactose-inducible GAL1 promoter. After induction by galactose, functional h{beta}-AR was expressed at a concentration several hundred times as great as that found in any human tissue. As determined from competitive ligand binding experiments, h{beta}-AR expressed in yeast displayed characteristic affinities, specificity, and stereoselectivity. Partial activation of the yeast pheromone response pathway by {beta}-adrenergic receptor agonists was achieved in cells coexpressing h{beta}-AR and a mammalian G protein (G{sub s}) {alpha} subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast. This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors.

  11. Lumbar disc arthroplasty with Maverick disc versus stand-alone interbody fusion: a prospective, randomized, controlled, multicenter investigational device exemption trial.

    Science.gov (United States)

    Gornet, Matthew F; Burkus, J Kenneth; Dryer, Randall F; Peloza, John H

    2011-12-01

    Randomized, controlled, multicenter, investigational device exemption trial. To investigate the safety and effectiveness of the first two-piece, metal-on-metal lumbar disc prosthesis for treating patients with single-level degenerative disc disease. For patients with degenerative disc disease unresponsive to conservative measures, lumbar disc arthroplasty provides an alternative to fusion designed to relieve persistent discogenic pain and maintain motion. After 2:1 randomization, 577 patients were treated in either the investigational group (405), receiving lumbar disc arthroplasty, or the control group (172), receiving anterior lumbar interbody fusion. Patients were evaluated preoperatively, at surgery/discharge, and at 1.5, 3, 6, 12, and 24 months after surgery. The primary study endpoint was overall success, a composite measure of safety and effectiveness as recommended by the Food and Drug Administration and defined in the protocol. Both treatment groups demonstrated significant improvements compared with preoperative status. The investigational group had statistically superior outcomes (P < 0.05) at all postoperative evaluations in Oswestry Disability Index, back pain, and Short Form-36 Physical Component Summary scores as well as patient satisfaction. Investigational patients had longer surgical times (P < 0.001) and greater blood loss (P < 0.001) than did control patients; however, hospitalization stays were similar for both groups. Investigational patients had fewer implant or implant/surgical procedure-related adverse events (P < 0.001). Return-to-work intervals were reduced for investigational patients. Disc height and segmental angular motion were maintained throughout the study in the investigational group. In the investigational group, overall success superiority was found when compared to the control group as defined by the Food and Drug Administration Investigational Device Exemption protocol. The investigational group consistently demonstrated

  12. Design of a Quality Control Program for the Measurement of Gross Alpha and Gross Beta Activities (LMPR-CIEMAT); Diseno del Control de Calidad de las Medidas de Actividad Alfa-Beta Total (LMPR-CIEMAT)

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, A.; Yague, L.; Gasco, C.; Navarro, N.; Higueras, E.; Noguerales, C.

    2010-10-21

    In accordance with international standards, general requirements for testing laboratories have to include a quality system for planning, implementing, and assessing the work performed by the organization and for carrying out required quality assurance and quality control. The purpose of internal laboratory quality control is to monitor performance, identify problems, and initiate corrective actions. This report describes the internal quality control to monitor the gross alpha and beta activities determination. Identification of specific performance indicators, the principles that govern their use and statistical means of evaluation are explained. Finally, calculation of alpha and beta specific activities, uncertainties and detection limits are performed. (Author) 10 refs.

  13. Avalanche boron fusion by laser picosecond block ignition with magnetic trapping for clean and economic reactor

    CERN Document Server

    Hora, H; Eliezer, S; Lalousis, N Nissim P; Giuffrida, L; Margarone, D; Picciotto, A; Miley, G H; Moustaizis, S; Martinez-Val, J -M; Barty, C P J; Kirchhoff, G J

    2016-01-01

    After the very long consideration of the ideal energy source by fusion of the protons of light hydrogen with the boron isotope 11 (boron fusion HB11) the very first two independent measurements of very high reaction gains by lasers basically opens a fundamental breakthrough. The non-thermal plasma block ignition with extremely high power laser pulses above petawatt of picosecond duration in combination with up to ten kilotesla magnetic fields for trapping has to be combined to use the measured high gains as proof of an avalanche reaction for an environmentally clean, low cost and lasting energy source as potential option against global warming. The unique HB11 avalanche reaction is are now based on elastic collisions of helium nuclei (alpha particles) limited only to a reactor for controlled fusion energy during a very short time within a very small volume.

  14. Improvement of cloned [alpha]-amylase gene expression in fed-batch culture of recombinant Saccharomyces cerevisiae by regulating both glucose and ethanol concentrations using a fuzzy controller

    Energy Technology Data Exchange (ETDEWEB)

    Shiba, Sumihisa; Nishida, Yoshio; Park, Y.S.; Iijima, Shinji; Kobayashi, Takeshi (Nagoya Univ. (Japan). Dept. of Biotechnology)

    1994-11-05

    The effect of ethanol concentration on cloned gene expression in recombinant Saccharomyces cerevisiae strain 20B-12 containing one of two plasmids, pNA3 and pNA7, was investigated in batch cultures. Plasmids pNA3 and pNA7 contain the [alpha]-amylase gene under the control of the SUC2 or PGK promoter, respectively. When the ethanol concentration was controlled at 2 to 5 g/L, the gene expressions were two times higher than those at 20 g/L ethanol. To increase the gene expression by maintaining both the ethanol and glucose concentrations at low levels, a fuzzy controller was developed. The concentrations of glucose and ethanol were controlled simultaneously at 0.15 and 2 g/L, respectively, in the production phase using the fuzzy controller in fed-batch culture. The synthesis of [alpha]-amylase was induced by the low glucose concentration and maintained at a high level of activity by regulating the ethanol concentration at 2 g/L. The secretory [alpha]-amylase activities of cells harboring plasmids pNA3 and pNA7 in fed-batch culture were 175 and 392 U/mL, and their maximal specific activities 7.7 and 12.4 U/mg dry cells, respectively. These values are two to three times higher in activity and three to four times higher in specific activity than those obtained when glucose only was controlled.

  15. Alpha Blockers

    Science.gov (United States)

    ... positive side, alpha blockers might decrease low-density lipoprotein (LDL) cholesterol (the "bad" cholesterol). Alpha blockers can ... PreventionTreatmentofHighBloodPressure/Types-of-Blood-Pressure-Medications_UCM_303247_Article.jsp. Accessed June 4, 2016. Kaplan NM, et ...

  16. Fusion energy and nuclear non-proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Goldston, Rob [Princeton Plasma Physics Lab, Princeton (United States)

    2014-07-01

    Neutrons from DT fusion can be used to produce {sup 239}Pu or {sup 233}U. However since no fertile nor fissile material need be present in a pure fusion power plant, it would be relatively easy to detect significant covert transmutation in a declared facility. Clandestine fusion-based transmutation does not appear credible. Furthermore, no fissile materials are immediately available in a fusion breakout scenario. DT fusion systems produce and burn 400g of tritium per day, a small fraction of which, if diverted, could be used to enhance the efficiency, reliability and/or safety of a nuclear weapon. Very accurate T accountancy needs to be developed for fusion energy systems. Finally, the spread of inertial fusion energy R and D may result in dissemination of knowledge relevant to the design of nuclear weapons. International agreements to restrain information transfer are required. In summary, fusion is much safer from a proliferation standpoint than fission, but still requires verification and control.

  17. Magnetic fusion; La fusion magnetique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This document is a detailed lecture on thermonuclear fusion. The basic physics principles are recalled and the technological choices that have led to tokamaks or stellarators are exposed. Different aspects concerning thermonuclear reactors such as safety, economy and feasibility are discussed. Tore-supra is described in details as well as the ITER project.

  18. 成人脊柱滑脱后外侧融合术远期疗效随机对照研究%The long-term effect of posterolateral fusion in adult isthmic spondylolisthesis: a randomized controlled study

    Institute of Scientific and Technical Information of China (English)

    Ekman P; Moller H; Hedlund R

    2005-01-01

    BACKGROUND: Today there is some evidence-based medicine support for a positive shortterm treatment effect of fusion in chronic low back pain in spondylolisthesis and in nonspecific degenerative lumbar spine disorders. The long-term effect is, however, unknown. PURPOSE: To determine the long-term outcome of lumbar fusion in adult isthmic spondylolisthesis. STUDY DESIGN:Prospective, randomized controlled study comparing a 1-year exercise program with instrumented an dnon-instrumented posterolateral fusion with average long-term follow-up of 9 years (range,5-13)。

  19. Intense fusion neutron sources

    Science.gov (United States)

    Kuteev, B. V.; Goncharov, P. R.; Sergeev, V. Yu.; Khripunov, V. I.

    2010-04-01

    The review describes physical principles underlying efficient production of free neutrons, up-to-date possibilities and prospects of creating fission and fusion neutron sources with intensities of 1015-1021 neutrons/s, and schemes of production and application of neutrons in fusion-fission hybrid systems. The physical processes and parameters of high-temperature plasmas are considered at which optimal conditions for producing the largest number of fusion neutrons in systems with magnetic and inertial plasma confinement are achieved. The proposed plasma methods for neutron production are compared with other methods based on fusion reactions in nonplasma media, fission reactions, spallation, and muon catalysis. At present, intense neutron fluxes are mainly used in nanotechnology, biotechnology, material science, and military and fundamental research. In the near future (10-20 years), it will be possible to apply high-power neutron sources in fusion-fission hybrid systems for producing hydrogen, electric power, and technological heat, as well as for manufacturing synthetic nuclear fuel and closing the nuclear fuel cycle. Neutron sources with intensities approaching 1020 neutrons/s may radically change the structure of power industry and considerably influence the fundamental and applied science and innovation technologies. Along with utilizing the energy produced in fusion reactions, the achievement of such high neutron intensities may stimulate wide application of subcritical fast nuclear reactors controlled by neutron sources. Superpower neutron sources will allow one to solve many problems of neutron diagnostics, monitor nano-and biological objects, and carry out radiation testing and modification of volumetric properties of materials at the industrial level. Such sources will considerably (up to 100 times) improve the accuracy of neutron physics experiments and will provide a better understanding of the structure of matter, including that of the neutron itself.

  20. Comparison of adjacent segment degeneration five years after single level cervical fusion and cervical arthroplasty:a retrospective controlled study

    Institute of Scientific and Technical Information of China (English)

    SUN Yu; ZHAO Yan-bin; PAN Sheng-fa; ZHOU Fei-fei; CHEN Zhong-qiang; LIU Zhong-jun

    2012-01-01

    Background Cervical arthroplasty is indicated to preserve cervical motion and prevent accelerated adjacent segment degeneration.Whether accelerated adjacent segment degeneration is prevented in the long term is unclear.This trial compared adjacent segment degeneration in Bryan disc arthroplasty with that in anterior cervical decompression and fusion five years after the surgery.Methods We studied patients with single level degenerative cervical disc disease.The extent of adjacent segment degeneration was estimated from lateral X-rays.Results Twenty-six patients underwent single level Bryan disc arthroplasty and twenty-four patients underwent single level anterior cervical decompression and fusion.All patients were followed up for an average of sixty months.In the Bryan arthroplasty group,nine(17.6%)segments developed adjacent segment degeneration,which was significantly lower than that(60.4%)in the anterior cervical decompression and fusion group.Eleven segments in the Bryan arthroplasty group developed heterotopic ossification according to McAfee's classification and two segments had range of motion less than 2°.In the heterotopic ossification group,four(19.5%)segments developed adjacent segment degeneration,similar to the number in the non-heterotopic ossification group(16.7%).Adjacent segment degeneration rate was 50% in gradeⅣ?group but 11.8% in gradeⅡ?to Ⅲ.Conclusions Adjacent segment degeneration was accelerated after anterior cervical decompression and fusion.However,Bryan disc arthroplasty avoided accelerated adjacent segment degeneration by preserving motion.Patients with gradeⅣ?heterotopic ossification lost motion,and the rate of adjacent segment degeneration was higher than that in patients without heterotopic ossification.

  1. EDITORIAL: The Nuclear Fusion Award The Nuclear Fusion Award

    Science.gov (United States)

    Kikuchi, M.

    2011-01-01

    Explanation of the JET n = 0 chirping mode Nucl. Fusion 46 S888-97 Urano H. et al 2006 Confinement degradation with beta for ELMy HH-mode plasmas in JT-60U tokamak Nucl. Fusion 46 781-7 Izzo V.A. et al 2006 A numerical investigation of the effects of impurity penetration depth on disruption mitigation by massive high-pressure gas jet Nucl. Fusion 46 541-7 Inagaki S. et al 2006 Comparison of transient electron heat transport in LHD helical and JT-60U tokamak plasmas Nucl. Fusion 46 133-41 Watanabe T.-H. et al 2006 Velocity-space structures of distribution function in toroidal ion temperature gradient turbulence Nucl. Fusion 46 24-32 2010 Nuclear Fusion Award nominees For the 2010 award, the papers published in the 2007 volume were assessed and the following papers were nominated, all of which are magnetic confinement experiments and theory. Rice J.E. et al 2007 Inter-machine comparison of intrinsic toroidal rotation in tokamaks Nucl. Fusion 47 1618-24 Lipschultz B. et al 2007 Plasma-surface interaction, scrape-off layer and divertor physics: implications for ITER Nucl. Fusion 47 1189-205 Loarer T. et al 2007 Gas balance and fuel retention in fusion devices Nucl. Fusion 47 1112-20 Garcia O.E et al 2007 Fluctuations and transport in the TCV scrape-off layer Nucl. Fusion 47 667-76 Zonca F. et al 2007 Electron fishbones: theory and experimental evidence Nucl. Fusion 47 1588-97 Maggi C.F. et al 2007 Characteristics of the H-mode pedestal in improved confinement scenarios in ASDEX Upgrade, DIII-D, JET and JT-60U Nucl. Fusion 47 535-51 Yoshida M. et al 2007 Momentum transport and plasma rotation profile in toroidal direction in JT-60U L-mode plasmas Nucl. Fusion 47 856-63 Zohm H. et al 2007 Control of MHD instabilities by ECCD: ASDEX Upgrade results and implications for ITER Nucl. Fusion 47 228-32 Snyder P.B. et al 2007 Stability and dynamics of the edge pedestal in the low collisionality regime: physics mechanisms for steady-state ELM-free operation Nucl. Fusion 47 961-8 Urano H. et

  2. Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis.

    Science.gov (United States)

    Singh, Ravi K; Xia, Zheng; Bland, Christopher S; Kalsotra, Auinash; Scavuzzo, Marissa A; Curk, Tomaz; Ule, Jernej; Li, Wei; Cooper, Thomas A

    2014-08-21

    Alternative splicing plays important regulatory roles during periods of physiological change. During development, a large number of genes coordinately express protein isoform transitions regulated by alternative splicing; however, the mechanisms that coordinate splicing and the functional integration of the resultant tissue-specific protein isoforms are typically unknown. Here we show that the conserved Rbfox2 RNA binding protein regulates 30% of the splicing transitions observed during myogenesis and is required for the specific step of myoblast fusion. Integration of Rbfox2-dependent splicing outcomes from RNA-seq with Rbfox2 iCLIP data identified Mef2d and Rock2 as Rbfox2 splicing targets. Restored activities of Mef2d and Rock2 rescued myoblast fusion in Rbfox2-depleted cultures, demonstrating functional cooperation of protein isoforms generated by coordinated alterative splicing. The results demonstrate that coordinated alternative splicing by a single RNA binding protein modulates transcription (Mef2d) and cell signaling (Rock2) programs to drive tissue-specific functions (cell fusion) to promote a developmental transition.

  3. Tame Fusion

    Institute of Scientific and Technical Information of China (English)

    S.D. Scott

    2003-01-01

    The first section of this paper covers preliminaries. Essentially, the next four cover units. It is shown that a compatible nearring with DCCR is Nnilpotent if and only if every maximal right N-subgroup is a right ideal. The last five sections relate to fusion (I.e., N-groups minimal for being generated by Nsubgroups, where each is N-isomorphic to a given N-group). Right N-subgroups of a tame nearring N with DCCR, minimal for not annihilating a minimal ideal from the left, are self monogenic and N-isomorphic. That this holds for any collection of minimal ideals is significant. Here, the right N-subgroup involved is a 'fusion product' of the 'components'.

  4. Control of. cap alpha. -amylase mRNA accumulation by gibberellic acid and calcium in barley aleurone layers

    Energy Technology Data Exchange (ETDEWEB)

    Deikman, J.; Jones, R.L.

    1985-01-01

    Pulse-labeling of barley (Hordeum vulgare L. cv Himalaya) aleurone layers incubated for 13 hours in 2.5 micromolar gibberellic acid (GA/sub 3/) with or without 5 millimolar CaCl/sub 2/ shows that ..cap alpha..-amylase isozymes 3 and 4 are not synthesized in vivo in the absence of Ca/sup 2 +/. No difference was observed in ..cap alpha..-amylase mRNA levels between layers incubated for 12 hours in 2.5 micromolar GA/sub 3/ with 5 millimolar CaCl/sub 2/ and layers incubated in GA/sub 3/ alone. RNA isolated from layers incubated for 12 hours in GA/sub 3/ with and without CA/sup 2 +/. A cDNA clone for ..cap alpha..-amylase was isolated and used to measure ..cap alpha..-amylase mRNA levels in aleurone layers incubated in the presence and absence of Ca/sup 2 +/ was translated in vitro and was found to produce the same complement of translation products regardless of the presence of Ca/sup 2 +/ in the incubation medium. Immunoprecipitation of translation products showed that the RNA for ..cap alpha..-amylase synthesized in Ca/sup 2 +/-deprived aleurone layers was translatable. Ca/sup 2 +/ is required for the synthesis of ..cap alpha..-amylase isozymes 3 and 4 at a step after mRNA accumulation and processing.

  5. Carpal Fusion

    OpenAIRE

    2012-01-01

    Carpal fusion may be seen in hereditary and nonhereditary conditions such as acrocallosal syndrome,acromegaly, Apert syndrome, arthrogryposis, Carpenter syndrome, chromosomal abnormalities, ectrodactyly-ectodermal dysplasia-cleft (EEC) syndrome, the F form of acropectorovertebral dysgenesis or the F syndrome, fetal alcohol syndrome, Holt-Oram syndrome, Leopard syndrome, multiple synostosis syndrome, oligosyndactyly syndrome, Pfeiffer-like syndrome, scleroderma, split hand and foot malformatio...

  6. Fusion rules of equivariantizations of fusion categories

    OpenAIRE

    2012-01-01

    We determine the fusion rules of the equivariantization of a fusion category $\\mathcal{C}$ under the action of a finite group $G$ in terms of the fusion rules of $\\mathcal{C}$ and group-theoretical data associated to the group action. As an application we obtain a formula for the fusion rules in an equivariantization of a pointed fusion category in terms of group-theoretical data. This entails a description of the fusion rules in any braided group-theoretical fusion category.

  7. Fusion rules of equivariantizations of fusion categories

    OpenAIRE

    Burciu, Sebastian; Natale, Sonia

    2012-01-01

    We determine the fusion rules of the equivariantization of a fusion category $\\mathcal{C}$ under the action of a finite group $G$ in terms of the fusion rules of $\\mathcal{C}$ and group-theoretical data associated to the group action. As an application we obtain a formula for the fusion rules in an equivariantization of a pointed fusion category in terms of group-theoretical data. This entails a description of the fusion rules in any braided group-theoretical fusion category.

  8. Controlled-release interferon alpha 2b, a new member of the interferon family for the treatment of chronic hepatitis C.

    Science.gov (United States)

    Jansen, Peter L M; De Bruijne, Joep

    2012-01-01

    Combination therapy with pegylated interferon alpha (Peg-interferon) and ribavirin is currently the cornerstone of antiviral therapy for chronic hepatitis C. Monotherapy with Peg-interferon still is important for the treatment of chronic hepatitis B. With the advent of new therapies, protease inhibitors for chronic hepatitis C and nucleotide inhibitors for chronic hepatitis B, there remains a need for interferon-based therapies. The side effects of Peg-interferon are a main disadvantage and represent a stumbling block for many patients to enter and continue therapy. In this review, the authors will discuss controlled-release interferon alpha 2b (CR2b) (Locteron®, Biolex Therapeutics, Pittsboro, NC, USA), a new slow-release interferon alpha 2b preparation for the treatment of chronic viral hepatitis. Other alternative interferons will also be discussed. CR2b is a slow-release microsphere preparation for the administration of plant-derived recombinant human interferon alpha 2b. Compared with Peg-interferon, treatment with CR2b shows less flu-like reactions and less depression, and is at least as effective as conventional Peg-interferon-based therapy in patients with chronic hepatitis C. CR2b has the added advantage of biweekly instead of once weekly administration. CR2b appears to cause more neutropenia than Peg-interferon alpha 2b. This may be due to higher trough serum levels of CR2b at the end of a dosing interval. The bone marrow effects of CR2b closely resemble those published for the registered Peg-interferon alpha 2a. CR2b appears to have at least comparable efficacy with fewer side effects than current registered Peg-interferons.

  9. Neutral particle kinetics in fusion devices

    Energy Technology Data Exchange (ETDEWEB)

    Tendler, M.; Heifetz, D.

    1986-05-01

    The theory of neutral particle kinetics treats the transport of mass, momentum, and energy in a plasma due to neutral particles which themselves are unaffected by magnetic fields. This transport affects the global power and particle balances in fusion devices, as well as profile control and plasma confinement quality, particle and energy fluxes onto device components, performance of pumping systems, and the design of diagnostics and the interpretation of their measurements. This paper reviews the development of analytic, numerical, and Monte Carlo methods of solving the time-independent Boltzmann equation describing neutral kinetics. These models for neutral particle behavior typically use adaptations of techniques developed originally for computing neutron transport, due to the analogy between the two phenomena, where charge-exchange corresponds to scattering and ionization to absorption. Progress in the field depends on developing multidimensional analytic methods, and obtaining experimental data for the physical processes of wall reflection, the neutral/plasma interaction, and for processes in fusion devices which are directly related to neutral transport, such as H/sub ..cap alpha../ emission rates, plenum pressures, and charge-exchange emission spectra.

  10. The Neurospora Transcription Factor ADV-1 Transduces Light Signals and Temporal Information to Control Rhythmic Expression of Genes Involved in Cell Fusion

    Directory of Open Access Journals (Sweden)

    Rigzin Dekhang

    2017-01-01

    Full Text Available Light and the circadian clock have a profound effect on the biology of organisms through the regulation of large sets of genes. Toward understanding how light and the circadian clock regulate gene expression, we used genome-wide approaches to identify the direct and indirect targets of the light-responsive and clock-controlled transcription factor ADV-1 in Neurospora crassa. A large proportion of ADV-1 targets were found to be light- and/or clock-controlled, and enriched for genes involved in development, metabolism, cell growth, and cell fusion. We show that ADV-1 is necessary for transducing light and/or temporal information to its immediate downstream targets, including controlling rhythms in genes critical to somatic cell fusion. However, while ADV-1 targets are altered in predictable ways in Δadv-1 cells in response to light, this is not always the case for rhythmic target gene expression. These data suggest that a complex regulatory network downstream of ADV-1 functions to generate distinct temporal dynamics of target gene expression relative to the central clock mechanism.

  11. Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum.

    Science.gov (United States)

    Porcu, Patrizia; O'Buckley, Todd K; Alward, Sarah E; Marx, Christine E; Shampine, Lawrence J; Girdler, Susan S; Morrow, A Leslie

    2009-01-01

    The 3alpha,5alpha- and 3alpha,5beta-reduced derivatives of progesterone, deoxycorticosterone, dehydroepiandrosterone and testosterone enhance GABAergic neurotransmission and produce inhibitory neurobehavioral and anti-inflammatory effects. Despite substantial information on the progesterone derivative (3alpha,5alpha)-3-hydroxypregnan-20-one (3alpha,5alpha-THP, allopregnanolone), the physiological significance of the other endogenous GABAergic neuroactive steroids has remained elusive. Here, we describe the validation of a method using gas chromatography-mass spectrometry to simultaneously identify serum levels of the eight 3alpha,5alpha- and 3alpha,5beta-reduced derivatives of progesterone, deoxycorticosterone, dehydroepiandrosterone and testosterone. The method shows specificity, sensitivity and enhanced throughput compared to other methods already available for neuroactive steroid quantification. Administration of pregnenolone to rats and progesterone to women produced selective effects on the 3alpha,5alpha- and 3alpha,5beta-reduced neuroactive steroids, indicating differential regulation of their biosynthetic pathways. Pregnenolone administration increased serum levels of 3alpha,5alpha-THP (+1488%, psteroid was detected only in 3/16 control subjects. Levels of 3alpha,5alpha-A, 3alpha,5beta-A and pregnenolone were not altered. This method can be used to investigate the physiological and pathological role of neuroactive steroids and to develop biomarkers and new therapeutics for neurological and psychiatric disorders.

  12. Unilateral versus bilateral pedicle screw fixation of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF): a meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Wang, Liang; Wang, Yipeng; Li, Zhengyao; Yu, Bin; Li, Ye

    2014-11-06

    A few studies focused on unilateral or bilateral pedicle screw (PS) fixation of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) to treat lumbar degenerative diseases have been published. There is still debate over whether one method is superior to another. A systematic review and meta-analysis of randomized controlled trials (RCT) was performed to compare the efficacy of the two methods. We searched the established electronic literature databases of MEDLINE, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials databases for RCTs comparing the unilateral with bilateral pedicle screw fixation of MIS-TLIF. Pooled mean differences (MD) and odds ratios (OR) and with 95% CIs were calculated for the outcomes. Three RCTs were identified and analyzed. The results showed that there is no significant difference between the two methods in terms of postoperative VAS-BP score (WMD = -0.09; 95% CI: -0.69 to 0.51; P =0.78), ODI (WMD, -0.09; 95% CI -5.85 to 5.67; P =0.98), fusion rate (OR = 2.99; 95% CI 0.55 to 16.38; P = 0.21) or complication rate (OR = 1.61, 95% CI: 0.49 to 5.37; P =0.43). Unilateral pedicle screw fixation was associated with less blood loss (WMD = -87.83; 95% CI: -160.70 to -14.96; P =0.02). The existing evidence indicate that no superiority exists between the two fixation methods of MIS-TLIF in terms of functional outcome, fusion rate and complication rate, in spite of that unilateral pedicle screw fixation can achieve less blood loss than bilateral fixation.

  13. Recoil-alpha-fission and recoil-alpha-alpha-fission events observed in the reaction Ca-48 + Am-243

    CERN Document Server

    Forsberg, U; Andersson, L -L; Di Nitto, A; Düllmann, Ch E; Gates, J M; Golubev, P; Gregorich, K E; Gross, C J; Herzberg, R -D; Hessberger, F P; Khuyagbaatar, J; Kratz, J V; Rykaczewski, K; Sarmiento, L G; Schädel, M; Yakushev, A; Åberg, S; Ackermann, D; Block, M; Brand, H; Carlsson, B G; Cox, D; Derkx, X; Dobaczewski, J; Eberhardt, K; Even, J; Fahlander, C; Gerl, J; Jäger, E; Kindler, B; Krier, J; Kojouharov, I; Kurz, N; Lommel, B; Mistry, A; Mokry, C; Nazarewicz, W; Nitsche, H; Omtvedt, J P; Papadakis, P; Ragnarsson, I; Runke, J; Schaffner, H; Schausten, B; Shi, Y; Thörle-Pospiech, P; Torres, T; Traut, T; Trautmann, N; Türler, A; Ward, A; Ward, D E; Wiehl, N

    2015-01-01

    Products of the fusion-evaporation reaction Ca-48 + Am-243 were studied with the TASISpec set-up at the gas-filled separator TASCA at the GSI Helmholtzzentrum f\\"ur Schwerionenforschung. Amongst the detected thirty correlated alpha-decay chains associated with the production of element Z=115, two recoil-alpha-fission and five recoil-alpha-alpha-fission events were observed. The latter are similar to four such events reported from experiments performed at the Dubna gas-filled separator. Contrary to their interpretation, we propose an alternative view, namely to assign eight of these eleven decay chains of recoil-alpha(-alpha)-fission type to start from the 3n-evaporation channel 115-288. The other three decay chains remain viable candidates for the 2n-evaporation channel 115-289.

  14. Introduction to Nuclear Fusion Power and the Design of Fusion Reactors. An Issue-Oriented Module.

    Science.gov (United States)

    Fillo, J. A.

    This three-part module focuses on the principles of nuclear fusion and on the likely nature and components of a controlled-fusion power reactor. The physical conditions for a net energy release from fusion and two approaches (magnetic and inertial confinement) which are being developed to achieve this goal are described. Safety issues associated…

  15. Introduction to Nuclear Fusion Power and the Design of Fusion Reactors. An Issue-Oriented Module.

    Science.gov (United States)

    Fillo, J. A.

    This three-part module focuses on the principles of nuclear fusion and on the likely nature and components of a controlled-fusion power reactor. The physical conditions for a net energy release from fusion and two approaches (magnetic and inertial confinement) which are being developed to achieve this goal are described. Safety issues associated…

  16. JENDL fusion file 99

    Energy Technology Data Exchange (ETDEWEB)

    Chiba, Satoshi; Fukahori, Tokio; Shibata, Keiichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Yu Baosheng [China Institute of Atomic Energy, Beijing (China); Kosako, Kazuaki [Sumitomo Atomic Industries, Tokyo (Japan); Yamamuro, Nobuhiro [Data Engineering Co. Ltd., Yokohama, Kanagawa (Japan)

    2002-02-01

    The double-differential cross sections (DDXs) of secondary neutrons have been evaluated for 79 isotopes and 13 natural elements ranging from H to Bi to improve the accuracy of predictions for the neutronics calculations in the D-T thermonuclear fusion applications. The data given in JENDL-3.1, which was the newest version of JENDL general purpose file when this project was initiated, was combined with new calculations based on the optical model, DWBA, pre-equilibrium and multi-step statistical models, and the DDX data were generated based on various kinds of systematics for medium-mass nuclei. Different methods were employed for light nuclei to which the above method could not be applied. In addition, the DDXs for emission of charged particles (p, d, t, {sup 3}He and {alpha}-particle) were given for {sup 2}H, {sup 9}Be and elements heavier or equal to F. The present results give an overall good description of the measured DDX data of both the neutron and charged particles emission channels. The data were compiled in ENDF-6 format, and released in 1999 as a special purpose file of JENDL family, namely, JENDL Fusion File 99. (author)

  17. Information integration for data fusion

    Energy Technology Data Exchange (ETDEWEB)

    Bray, O.H.

    1997-01-01

    Data fusion has been identified by the Department of Defense as a critical technology for the U.S. defense industry. Data fusion requires combining expertise in two areas - sensors and information integration. Although data fusion is a rapidly growing area, there is little synergy and use of common, reusable, and/or tailorable objects and models, especially across different disciplines. The Laboratory-Directed Research and Development project had two purposes: to see if a natural language-based information modeling methodology could be used for data fusion problems, and if so, to determine whether this methodology would help identify commonalities across areas and achieve greater synergy. The project confirmed both of the initial hypotheses: that the natural language-based information modeling methodology could be used effectively in data fusion areas and that commonalities could be found that would allow synergy across various data fusion areas. The project found five common objects that are the basis for all of the data fusion areas examined: targets, behaviors, environments, signatures, and sensors. Many of the objects and the specific facts related to these objects were common across several areas and could easily be reused. In some cases, even the terminology remained the same. In other cases, different areas had their own terminology, but the concepts were the same. This commonality is important with the growing use of multisensor data fusion. Data fusion is much more difficult if each type of sensor uses its own objects and models rather than building on a common set. This report introduces data fusion, discusses how the synergy generated by this LDRD would have benefited an earlier successful project and contains a summary information model from that project, describes a preliminary management information model, and explains how information integration can facilitate cross-treaty synergy for various arms control treaties.

  18. Alpha fetoprotein

    Science.gov (United States)

    Fetal alpha globulin; AFP ... Greater than normal levels of AFP may be due to: Cancer in testes , ovaries, biliary (liver secretion) tract, stomach, or pancreas Cirrhosis of the liver Liver cancer ...

  19. Concomitant production of two proteases and alpha-amylase by a novel strain of Bacillus subtilis in a microprocessor controlled bioreactor

    Directory of Open Access Journals (Sweden)

    Hamid Mukhtar

    2012-09-01

    Full Text Available We describe the simultaneous production of Bacillus subtilis based proteases and alpha amylase using a computer controlled laboratory scale 7.5 L batch bioreactor. The present strain is the first to be reported that concomitantly produces these two industrially important enzymes. The growth and sporulation of Bacillus subtilis was monitored and maximum production of alkaline protease and alpha amylase was found to coincide with maximum sporulation. Two types of proteases were detected in the fermentation broth; a neutral and an alkaline protease most active in a pH range of 7.0-8.0 and 8.0-10, respectively. Maximum production of proteases was observed at an incubation temperature of 37ºC while that of alpha amylase was observed at 40ºC. The optimum aeration and agitation levels for protease production were 0.6 L/L/min and 200rpm, respectively, and for alpha amylase were 0.6 L/L/min and 150 rpm. The kinetic parameters Yp/x and qp were also found to be significant at the given fermentation conditions.

  20. The effects of short-term alpha-ketoisocaproic acid supplementation on exercise performance: a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Yarrow Joshua F

    2007-07-01

    Full Text Available Abstract Background This study examined the efficacy of short-term alpha-ketoisocaproic acid (KIC monotherapy supplementation immediately prior to moderate- and high-intensity single bout exercise performance. Methods Thirteen resistance trained men (22.8 ± 2.5 years; 81.6 ± 12.6 kg participated in a prospective, randomized, double blind, placebo controlled crossover experiment. Each subject completed one familiarization and four experimental trials with either 1.5 g or 9.0 g of either KIC or isocaloric placebo control (CONT, following an overnight fast. During the experimental trials, subjects consumed the supplement regimen and then completed leg and chest press repetitions to failure and 30 s of repeated maximal vertical jumping (VJ on a force plate. Results In this treatment regimen, no significant differences (p > 0.05 were observed between dosages or conditions for leg press (low CONT = 19.8 ± 0.4 SEM, low KIC = 21.0 ± 0.5, high CONT = 20.1 ± 0.3, high KIC = 22.4 ± 0.6 or chest press (low CONT = 18.1 ± 0.2, low KIC = 18.5 ± 0.3, high CONT = 17.8 ± 0.3, high KIC = 18.0 ± 0.3 repetitions to failure. Additionally, no significant differences were observed for peak or mean VJ performance (low CONT = 34.6 ± 2.2 cm and 28.6 ± 1.8 cm; low KIC = 35.6 ± 2.0 cm and 29.4 ± 1.6 cm; high CONT = 35.7 ± 2.1 cm and 29.4 ± 1.7 cm; high KIC = 34.8 ± 2.3 cm and 28.3 ± 1.7 cm, respectively. Conclusion Based on our results, we conclude that acute KIC ingestion by itself with no other ergogenic supplement, immediately prior to exercise, did not alter moderate- nor high-intensity single-bout exercise performance in young resistance-trained males. This study addressed single-dose single-bout performance events; the efficacy of KIC monotherapy supplementation on repeated high-intensity exercise bouts and long-term exercise training remains unknown.

  1. FUSION WORLD

    Institute of Scientific and Technical Information of China (English)

    Caroline; 黄颖(翻译)

    2009-01-01

    Fusion World”科技展示体验中心是英国设计公司MET Studio为新加坡科技研究局(A*Star)的科学工程委员会(SERC)所设计的,位于启汇城的办公地点,用于展示该委员会的精选技术作品,以吸引潜在的客户和启汇城内的学生购买群体。

  2. EDITORIAL: Stochasticity in fusion plasmas Stochasticity in fusion plasmas

    Science.gov (United States)

    Unterberg, Bernhard

    2010-03-01

    Structure formation and transport in stochastic plasmas is a topic of growing importance in many fields of plasma physics from astrophysics to fusion research. In particular, the possibility to control transport in the boundary of confined fusion plasmas by resonant magnetic perturbations has been investigated extensively during recent years. A major research achievement was finding that the intense transient particle and heat fluxes associated with edge localized modes (here type-I ELMs) in magnetically confined fusion plasmas can be mitigated or even suppressed by resonant magnetic perturbation fields. This observation opened up a possible scheme to avoid too large erosion and material damage by such transients in future fusion devices such as ITER. However, it is widely recognized that a more basic understanding is needed to extrapolate the results obtained in present experiments to future fusion devices. The 4th workshop on Stochasticity in Fusion Plasmas was held in Jülich, Germany, from 2 to 4 March 2009. This series of workshops aims at gathering fusion experts from various plasma configurations such as tokamaks, stellarators and reversed field pinches to exchange knowledge on structure formation and transport in stochastic fusion plasmas. The workshops have attracted colleagues from both experiment and theory and stimulated fruitful discussions about the basics of stochastic fusion plasmas. Important papers from the first three workshops in 2003, 2005 and 2007 have been published in previous special issues of Nuclear Fusion (stacks.iop.org/NF/44/i=6, stacks.iop.org/NF/46/i=4 and stacks.iop.org/NF/48/i=2). This special issue comprises contributions presented at the 4th SFP workshop, dealing with the main subjects such as formation of stochastic magnetic layers, energy and particle transport in stochastic magnetic fields, plasma response to external, non-axis-symmetric perturbations and last but not least application of resonant magnetic perturbations for

  3. Carpal Fusion

    Directory of Open Access Journals (Sweden)

    Jalal Jalalshokouhi*

    2012-05-01

    Full Text Available Carpal fusion may be seen in hereditary and nonhereditary conditions such as acrocallosal syndrome,acromegaly, Apert syndrome, arthrogryposis, Carpenter syndrome, chromosomal abnormalities, ectrodactyly-ectodermal dysplasia-cleft (EEC syndrome, the F form of acropectorovertebral dysgenesis or the F syndrome, fetal alcohol syndrome, Holt-Oram syndrome, Leopard syndrome, multiple synostosis syndrome, oligosyndactyly syndrome, Pfeiffer-like syndrome, scleroderma, split hand and foot malformation, Stickler syndrome, thalidomide embryopathy, Turner syndrome and many other conditions as mentioned in Rubinstein-Taybi's book. Sometimes there is no known causative disease.Diagnosis is usually made by plain X-ray during studying a syndrome or congenital disease or could be an incidental finding like our patients. Hand bone anomalies are more common in syndromes or other congenital or non-hereditary conditions, but polydactyly, syndactyly or oligodactyly and carpal fusions are interesting. X-ray is the modality of choice, but MRI and X-ray CT with multiplanar reconstructions may be used for diagnosis.

  4. Incomplete vs. Complete Fusion at E/A {approx} 4-7 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Pushpendra P [INFN - Laboratori Nazionali di Legnaro, 1-35020 Legnaro (Italy); Yadav, Abhishek; Sharma, Vijay R; Singh, Devendra P; Gupta, Unnati; Singh, B P; Prasad, R [Accelerator Laboratory, Department of Physics, A. M. University, Aligarh-202 002 (India); Sharma, Manoj K [Physics Department, S. V. College, Aligarh-202 001 (India); Kumar, R; Golda, K S; Singh, R P; Muralithar, S; Bhowmik, R K, E-mail: pushpendrapsingh@gmail.com [NP-Group, Inter-University Accelerator Center, New Delhi-110 067 (India)

    2011-02-01

    With a view to study onset and strength of incomplete fusion at low projectile energies (i.e., {approx} 4-7 MeV/nucleon) three sets of experiments have been performed in {sup 12}C,{sup 16}O+{sup 169}Tm systems. In first set of experiments, spin-distributions and feeding intensity profiles for xn,{alpha}xn/2{alpha}xn-channels have been measured to figure out associated l-values. The spin-distributions for direct-{alpha}-emitting channels (associated with incomplete fusion) have been found to be distinctly different than that observed for fusion-evaporation (complete fusion) channels. The mean value of driving input angular momenta associated with direct-{alpha}-emitting-channels have been found to be higher than that observed for fusion-evaporation xn/{alpha}-emitting-channels, and increases with direct-{alpha}-multiplicity in forward cone. The second set of experiments has been performed to understand influence of incomplete fusion on complete fusion at these energies. Incomplete fusion strength function has been deduced from the analysis of experimental excitation functions. The third set of experiments deals with the validation of data reduction procedure used to deduce incomplete fusion fraction, and to confirm the fusion incompleteness at slightly above barrier energies. Forward-recoil-ranges of heavy reaction products have been measured and analysed on the basis of break-up fusion model. More than one linear-momentum-transfer components associated with full- and/or partial-fusion of projectile with target nucleus have been observed. Experimental ranges of forward-recoils are found to be in good agreement with that estimated using range-energy formulation. The relative strengths of complete and incomplete fusion components deduced from the analysis of forward-recoil-ranges and excitation functions complement each other. Result presented in this paper conclusively demonstrate substantial incomplete fusion contribution at energy as low as 7% above the barrier.

  5. Design Specification for a Thrust-Vectoring, Actuated-Nose-Strake Flight Control Law for the High-Alpha Research Vehicle

    Science.gov (United States)

    Bacon, Barton J.; Carzoo, Susan W.; Davidson, John B.; Hoffler, Keith D.; Lallman, Frederick J.; Messina, Michael D.; Murphy, Patrick C.; Ostroff, Aaron J.; Proffitt, Melissa S.; Yeager, Jessie C.; hide

    1996-01-01

    Specifications for a flight control law are delineated in sufficient detail to support coding the control law in flight software. This control law was designed for implementation and flight test on the High-Alpha Research Vehicle (HARV), which is an F/A-18 aircraft modified to include an experimental multi-axis thrust-vectoring system and actuated nose strakes for enhanced rolling (ANSER). The control law, known as the HARV ANSER Control Law, was designed to utilize a blend of conventional aerodynamic control effectors, thrust vectoring, and actuated nose strakes to provide increased agility and good handling qualities throughout the HARV flight envelope, including angles of attack up to 70 degrees.

  6. Radiofrequency bipolar hemostatic sealer reduces blood loss, transfusion requirements, and cost for patients undergoing multilevel spinal fusion surgery: a case control study.

    Science.gov (United States)

    Frank, Steven M; Wasey, Jack O; Dwyer, Ian M; Gokaslan, Ziya L; Ness, Paul M; Kebaish, Khaled M

    2014-07-05

    A relatively new method of electrocautery, the radiofrequency bipolar hemostatic sealer (RBHS), uses saline-cooled delivery of energy, which seals blood vessels rather than burning them. We assessed the benefits of RBHS as a blood conservation strategy in adult patients undergoing multilevel spinal fusion surgery. In a retrospective cohort study, we compared blood utilization in 36 patients undergoing multilevel spinal fusion surgery with RBHS (Aquamantys, Medtronic, Minneapolis, MN, USA) to that of a historical control group (n = 38) matched for variables related to blood loss. Transfusion-related costs were calculated by two methods. Patient characteristics in the two groups were similar. Intraoperatively, blood loss was 55% less in the RBHS group than in the control group (810 ± 530 vs. 1,800 ± 1,600 mL; p = 0.002), and over the entire hospital stay, red cell utilization was 51% less (2.4 ± 3.4 vs. 4.9 ± 4.5 units/patient; p = 0.01) and plasma use was 56% less (1.1 ± 2.4 vs. 2.5 ± 3.4 units/patient; p = 0.03) in the RBHS group. Platelet use was 0.1 ± 0.5 and 0.3 ± 0.6 units/patient in the RBHS and control groups, respectively (p = 0.07). The perioperative decrease in hemoglobin was less in the RBHS group than in the control group (-2.0 ± 2.2 vs. -3.2 ± 2.1 g/dL; p = 0.04), and hemoglobin at discharge was higher in the RBHS group (10.5 ± 1.4 vs. 9.7 ± 0.9 g/dL; p = 0.01). The estimated transfusion-related cost savings were $745/case by acquisition cost and approximately 3- to 5-fold this amount by activity-based cost. The use of RBHS in patients undergoing multilevel spine fusion surgery can conserve blood, promote higher hemoglobin levels, and reduce transfusion-related costs.

  7. ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation

    DEFF Research Database (Denmark)

    Lafuste, Peggy; Sonnet, Corinne; Chazaud, Bénédicte

    2005-01-01

    Knowledge on molecular systems involved in myogenic precursor cell (mpc) fusion into myotubes is fragmentary. Previous studies have implicated the a disintegrin and metalloproteinase (ADAM) family in most mammalian cell fusion processes. ADAM12 is likely involved in fusion of murine mpc and human...... extracellular matrix, suggesting specific involvement of ADAM12-alpha9beta1 interaction in the fusion process. Evaluation of the fusion rate with regard to the size of myotubes showed that both ADAM12 antisense oligonucleotides and alpha9beta1 blockade inhibited more importantly formation of large (> or =5...

  8. Heat transfer problems associated with laser fusion

    Energy Technology Data Exchange (ETDEWEB)

    Frank, T.G.; Bohachevsky, I.O.; Booth, L.A.; Pendergrass, J.H.

    1976-01-01

    Briefly discussed are the laser-initiated fusion reaction, emissions that are produced, and methods that may be used to protect the walls of reactor cavities from these emissions. Thermal loadings encountered in laser fusion reactors will consist of energy deposition by discrete, short, intense pulses of x and gamma rays, fast alpha and other charged particles, and fusion neutrons. Presented are models of energy deposition in structural walls and blanket regions surrounding the reaction chamber and methods used to calculate resulting temperature increases and thermal stresses in these components. The results of such calculations indicate that the design conditions for the engineering of laser-initiated fusion reactors will be severe and a great amount of ingenuity and analysis will be required to meet them successfully.

  9. New trends in fusion research

    CERN Document Server

    CERN. Geneva

    2004-01-01

    The efforts of the international fusion community aim at demonstrating the scientific feasibility of thermonuclear fusion energy power plants. Understanding the behavior of burning plasmas, i.e. plasmas with strong self-heating, represents a primary scientific challenge for fusion research and a new science frontier. Although integrated studies will only be possible, in new, dedicated experimental facilities, such as the International Tokamak Experimental Reactor (ITER), present devices can address specific issues in regimes relevant to burning plasmas. Among these are an improvement of plasma performance via a reduction of the energy and particle transport, an optimization of the path to ignition or to sustained burn using additional heating and a control of plasma-wall interaction and energy and particle exhaust. These lectures address recent advances in plasma science and technology that are relevant to the development of fusion energy. Mention will be made of the inertial confinement line of research, but...

  10. Data Fusion Concepts and Ideas

    CERN Document Server

    Mitchell, H B

    2012-01-01

    “Data Fusion: Concepts and Ideas” provides a comprehensive introduction to the concepts and idea of multisensor data fusion. This textbook is an extensively revised second edition of the author's successful book: "Multi-Sensor Data Fusion: An Introduction". The book is self-contained and no previous knowledge of multi-sensor data fusion is assumed. The reader is made familiar with tools taken from a wide range of diverse subjects including: neural networks, signal processing, statistical estimation, tracking algorithms, computer vision and control theory which are combined by using a common statistical framework. As a consequence, the underlying pattern of relationships that exists between the different methodologies is made evident. The book is illustrated with many real-life examples taken from a diverse range of applications and contains an extensive list of modern references. The new completely revised and updated edition includes nearly 70 pages of new material including a full new chapter as well as...

  11. Establishment of an Institute for Fusion Studies. Technical progress report, November 1, 1994--October 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    The Institute for Fusion Studies is a national center for theoretical fusion plasma physics research. Its purposes are to (1) conduct research on theoretical questions concerning the achievement of controlled fusion energy by means of magnetic confinement--including both fundamental problems of long-range significance, as well as shorter-term issues; (2) serve as a national and international center for information exchange by hosting exchange visits, conferences, and workshops; and (3) train students and postdoctoral research personnel for the fusion energy program and plasma physics research areas. During FY 1995, a number of significant scientific advances were achieved at the IFS, both in long-range fundamental problems as well as in near-term strategic issues, consistent with the Institute`s mandate. Examples of these achievements include, for example, tokamak edge physics, analytical and computational studies of ion-temperature-gradient-driven turbulent transport, alpha-particle-excited toroidal Alfven eigenmode nonlinear behavior, sophisticated simulations for the Numerical Tokamak Project, and a variety of non-tokamak and non-fusion basic plasma physics applications. Many of these projects were done in collaboration with scientists from other institutions. Research discoveries are briefly described in this report.

  12. Catalysed fusion

    CERN Document Server

    Farley, Francis

    2012-01-01

    A sizzling romance and a romp with subatomic particles at CERN. Love, discovery and adventure in the city where nations meet and beams collide. Life in a large laboratory. As always, the challenges are the same. Who leads? Who follows? Who succeeds? Who gets the credit? Who gets the women or the men? Young Jeremy arrives in CERN and joins the quest for green energy. Coping with baffling jargon and manifold dangers, he is distracted by radioactive rats, lovely ladies and an unscrupulous rival. Full of doubts and hesitations, he falls for a dazzling Danish girl, who leads him astray. His brilliant idea leads to a discovery and a new route to cold fusion. But his personal life is scrambled. Does it bring fame or failure? Tragedy or triumph?

  13. Magnetized Target Fusion (MTF): Principles, Status, and International Collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Kirkpatrick, R.C.

    1998-11-16

    Magnetized target fusion (MTF) is an approach to thermonuclear fusion that is intermediate between the two extremes of inertial and magnetic confinement. Target plasma preparation is followed by compression to fusion conditions. The use of a magnetic field to reduce electron thermal conduction and potentially enhance DT alpha energy deposition allows the compression rate to be drastically reduced relative to that for inertial confinement fusion. This leads to compact systems with target driver power and intensity requirements that are orders of magnitude lower than for ICF. A liner on plasma experiment has been proposed to provide a firm proof of principle for MTF.

  14. $\\alpha_s$ review (2016)

    CERN Document Server

    d'Enterria, David

    2016-01-01

    The current world-average of the strong coupling at the Z pole mass, $\\alpha_s(m^2_{Z}) = 0.1181 \\pm 0.0013$, is obtained from a comparison of perturbative QCD calculations computed, at least, at next-to-next-to-leading-order accuracy, to a set of 6 groups of experimental observables: (i) lattice QCD "data", (ii) $\\tau$ hadronic decays, (iii) proton structure functions, (iv) event shapes and jet rates in $e^+e^-$ collisions, (v) Z boson hadronic decays, and (vi) top-quark cross sections in p-p collisions. In addition, at least 8 other $\\alpha_s$ extractions, usually with a lower level of theoretical and/or experimental precision today, have been proposed: pion, $\\Upsilon$, W hadronic decays; soft and hard fragmentation functions; jets cross sections in pp, e-p and $\\gamma$-p collisions; and photon F$_2$ structure function in $\\gamma\\,\\gamma$ collisions. These 14 $\\alpha_s$ determinations are reviewed, and the perspectives of reduction of their present uncertainties are discussed.

  15. The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex.

    Science.gov (United States)

    Wu, Hui-Qiu; Pereira, Edna F R; Bruno, John P; Pellicciari, Roberto; Albuquerque, Edson X; Schwarcz, Robert

    2010-01-01

    The cognitive deficits seen in schizophrenia patients are likely related to abnormal glutamatergic and cholinergic neurotransmission in the prefrontal cortex. We hypothesized that these impairments may be secondary to increased levels of the astrocyte-derived metabolite kynurenic acid (KYNA), which inhibits alpha7 nicotinic acetylcholine receptors (alpha7AChR) and may thereby reduce glutamate release. Using in vivo microdialysis in unanesthetized rats, we show here that nanomolar concentrations of KYNA, infused directly or produced in situ from its bioprecursor kynurenine, significantly decrease extracellular glutamate levels in the prefrontal cortex. This effect was prevented by the systemic administration of galantamine (3 mg/kg) but not by donepezil (2 mg/kg), indicating that KYNA blocks the allosteric potentiating site of the alpha7AChR, which recognizes galantamine but not donepezil as an agonist. In separate rats, reduction of prefrontal KYNA formation by (S)-4-ethylsulfonyl benzoylalanine, a specific inhibitor of KYNA synthesis, caused a significant elevation in extracellular glutamate levels. Jointly, our results demonstrate that fluctuations in endogenous KYNA formation bidirectionally influence cortical glutamate concentrations. These findings suggest that selective attenuation of cerebral KYNA production, by increasing glutamatergic tone, might improve cognitive function in individuals with schizophrenia.

  16. Status and problems of fusion reactor development.

    Science.gov (United States)

    Schumacher, U

    2001-03-01

    Thermonuclear fusion of deuterium and tritium constitutes an enormous potential for a safe, environmentally compatible and sustainable energy supply. The fuel source is practically inexhaustible. Further, the safety prospects of a fusion reactor are quite favourable due to the inherently self-limiting fusion process, the limited radiologic toxicity and the passive cooling property. Among a small number of approaches, the concept of toroidal magnetic confinement of fusion plasmas has achieved most impressive scientific and technical progress towards energy release by thermonuclear burn of deuterium-tritium fuels. The status of thermonuclear fusion research activity world-wide is reviewed and present solutions to the complicated physical and technological problems are presented. These problems comprise plasma heating, confinement and exhaust of energy and particles, plasma stability, alpha particle heating, fusion reactor materials, reactor safety and environmental compatibility. The results and the high scientific level of this international research activity provide a sound basis for the realisation of the International Thermonuclear Experimental Reactor (ITER), whose goal is to demonstrate the scientific and technological feasibility of a fusion energy source for peaceful purposes.

  17. Expression of the human granulocyte-macrophage colony stimulating factor (hGM-CSF) gene under control of the 5'-regulatory sequence of the goat alpha-S1-casein gene with and without a MAR element in transgenic mice.

    Science.gov (United States)

    Burkov, I A; Serova, I A; Battulin, N R; Smirnov, A V; Babkin, I V; Andreeva, L E; Dvoryanchikov, G A; Serov, O L

    2013-10-01

    Expression of the human granulocyte-macrophage colony-stimulating factor (hGM-CSF) gene under the control of the 5'-regulatory sequence of the goat alpha-S1-casein gene with and without a matrix attachment region (MAR) element from the Drosophila histone 1 gene was studied in four and eight transgenic mouse lines, respectively. Of the four transgenic lines carrying the transgene without MAR, three had correct tissues-specific expression of the hGM-CSF gene in the mammary gland only and no signs of cell mosaicism. The concentration of hGM-CSF in the milk of transgenic females varied from 1.9 to 14 μg/ml. One line presented hGM-CSF in the blood serum, indicating ectopic expression. The values of secretion of hGM-CSF in milk of 6 transgenic lines carrying the transgene with MAR varied from 0.05 to 0.7 μg/ml, and two of these did not express hGM-CSF. Three of the four examined animals from lines of this group showed ectopic expression of the hGM-CSF gene, as determined by RT-PCR and immunofluorescence analyses, as well as the presence of hGM-CSF in the blood serum. Mosaic expression of the hGM-CSF gene in mammary epithelial cells was specific to all examined transgenic mice carrying the transgene with MAR but was never observed in the transgenic mice without MAR. The mosaic expression was not dependent on transgene copy number. Thus, the expected "protective or enhancer effect" from the MAR element on the hGM-CSF gene expression was not observed.

  18. Efficacy of interferon alpha- 2b with or without ribavirin in thalassemia major patients with chronic hepatitis C virus infection: A randomized, double blind, controlled, parallel group trial

    Directory of Open Access Journals (Sweden)

    Hamid Kalantari

    2010-01-01

    Full Text Available Background: The aim of this study was to evaluate the effectiveness of monotherapy with interferon alpha- 2b and combination therapy with interferon alpha- 2b plus ribavirin on chronic hepatitis C infection in thalassaemic patients. Methods: In parallel group randomized, double blind, controlled trial, 32 thalassaemic patients with chronic hepatitis C infection completed the study. In a random fashion, one group was treated with three million units of interferon alpha- 2b three times a week plus ribavirin (800- 1200 mg daily. The second group received interferon alpha- 2b alone. Treatment duration was 24- 48 weeks. Primary efficacy variables were HCV RNA after treatment and sustained viral response (SVR six months after treatment. Results: The mean age of patients was 22 ± 7.4 years; 19 (59.4% were male and 13 (40.6 were female. At the end of treatment, no statistically significant differences were found between the groups in HCV RNA and AST. The proportion of patients with SVR six months after treatment was significantly greater in the monotherapy group (90.9% than in the combination therapy group (44.4%; p = 0.049. A significant difference in mean of ALT was also obtained at the end of treatment between monotherapy and combination therapy groups (30.4 ± 19.2 and 60.1 ± 48.9, respectively; p = 0.02. Response rates were not associated with genotype and severity of hepatitis C infection in both groups. Conclusions: These results suggest that monotherapy may be considered as the first- line therapy in patients with thalassemia.

  19. Waves for Alpha-Channeling in Mirror Machines

    Energy Technology Data Exchange (ETDEWEB)

    A. I. Zhmoginov and N. J. Fisch

    2009-07-08

    Alpha-channeling can, in principle, be implemented in mirror machines via exciting weaklydamped modes in the ion cyclotron frequency range with perpendicular wavelengths smaller than the alpha particle gyroradius. Assuming quasi-longitudinal or quasi-transverse wave propagation, we search systematically for suitable modes in mirror plasmas. Considering two device designs, a proof-of-principle facility and a fusion rector prototype, we in fact identify candidate modes suitable for alpha-channeling.

  20. Accelerator based fusion reactor

    Science.gov (United States)

    Liu, Keh-Fei; Chao, Alexander Wu

    2017-08-01

    A feasibility study of fusion reactors based on accelerators is carried out. We consider a novel scheme where a beam from the accelerator hits the target plasma on the resonance of the fusion reaction and establish characteristic criteria for a workable reactor. We consider the reactions d+t\\to n+α,d+{{}3}{{H}\\text{e}}\\to p+α , and p+{{}11}B\\to 3α in this study. The critical temperature of the plasma is determined from overcoming the stopping power of the beam with the fusion energy gain. The needed plasma lifetime is determined from the width of the resonance, the beam velocity and the plasma density. We estimate the critical beam flux by balancing the energy of fusion production against the plasma thermo-energy and the loss due to stopping power for the case of an inert plasma. The product of critical flux and plasma lifetime is independent of plasma density and has a weak dependence on temperature. Even though the critical temperatures for these reactions are lower than those for the thermonuclear reactors, the critical flux is in the range of {{10}22}-{{10}24}~\\text{c}{{\\text{m}}-2}~{{\\text{s}}-1} for the plasma density {ρt}={{10}15}~\\text{c}{{\\text{m}}-3} in the case of an inert plasma. Several approaches to control the growth of the two-stream instability are discussed. We have also considered several scenarios for practical implementation which will require further studies. Finally, we consider the case where the injected beam at the resonance energy maintains the plasma temperature and prolongs its lifetime to reach a steady state. The equations for power balance and particle number conservation are given for this case.

  1. TRITIUM ACCOUNTANCY IN FUSION SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Klein, J. E.; Farmer, D. A.; Moore, M. L.; Tovo, L. L.; Poore, A. S.; Clark, E. A.; Harvel, C. D.

    2014-03-06

    The US Department of Energy (DOE) has clearly defined requirements for nuclear material control and accountability (MC&A) of tritium whereas the International Atomic Energy Agency (IAEA) does not since tritium is not a fissile material. MC&A requirements are expected for tritium fusion machines and will be dictated by the host country or regulatory body where the machine is operated. Material Balance Areas (MBAs) are defined to aid in the tracking and reporting of nuclear material movements and inventories. Material subaccounts (MSAs) are established along with key measurement points (KMPs) to further subdivide a MBA to localize and minimize uncertainties in the inventory difference (ID) calculations for tritium accountancy. Fusion systems try to minimize tritium inventory which may require continuous movement of material through the MSAs. The ability of making meaningful measurements of these material transfers is described in terms of establishing the MSA structure to perform and reconcile ID calculations. For fusion machines, changes to the traditional ID equation will be discussed which includes breading, burn-up, and retention of tritium in the fusion device. The concept of “net” tritium quantities consumed or lost in fusion devices is described in terms of inventory taking strategies and how it is used to track the accumulation of tritium in components or fusion machines.

  2. Tritium accountancy in fusion systems

    Energy Technology Data Exchange (ETDEWEB)

    Klein, J.E.; Clark, E.A.; Harvel, C.D.; Farmer, D.A.; Tovo, L.L.; Poore, A.S. [Savannah River National Laboratory, Aiken, SC (United States); Moore, M.L. [Savannah River Nuclear Solutions, Aiken, SC (United States)

    2015-03-15

    The US Department of Energy (DOE) has clearly defined requirements for nuclear material control and accountability (MCA) of tritium whereas the International Atomic Energy Agency (IAEA) does not since tritium is not a fissile material. MCA requirements are expected for tritium fusion machines and will be dictated by the host country or regulatory body where the machine is operated. Material Balance Areas (MBA) are defined to aid in the tracking and reporting of nuclear material movements and inventories. Material sub-accounts (MSA) are established along with key measurement points (KMP) to further subdivide a MBA to localize and minimize uncertainties in the inventory difference (ID) calculations for tritium accountancy. Fusion systems try to minimize tritium inventory which may require continuous movement of material through the MSA. The ability of making meaningful measurements of these material transfers is described in terms of establishing the MSA structure to perform and reconcile ID calculations. For fusion machines, changes to the traditional ID equation will be discussed which includes breeding, burn-up, and retention of tritium in the fusion device. The concept of 'net' tritium quantities consumed or lost in fusion devices is described in terms of inventory taking strategies and how it is used to track the accumulation of tritium in components or fusion machines. (authors)

  3. Control mechanism for attenuation of thermal energy pulses using cold circulators in the cryogenic distribution system of fusion devices in tokamak configuration

    Science.gov (United States)

    Bhattacharya, R.; Sarkar, B.; Vaghela, H.; Shah, N.

    2014-01-01

    Operation and control of superconducting (SC) magnets in the fusion devices having tokamak configuration opens up the domain of varying peak thermal energy environment as a function of time, commensurate with the plasma pulses. The varied thermal energy environment, thus propagated to upstream of the cooling system, is responsible for the system level instability of the overall cryogenic system. The cryogenic distribution system, the regime of first impact point, therefore, has to be tuned so as to stay at the nearly stable zone of operation. The configuration of the cryogenic distribution system, considered in the present study, involves a liquid helium (LHe) bath as a thermal buffer, LHe submerged heat exchangers and cold circulator apart from the valves for implementations of the precise controls. The cold circulator supplies the forced flow supercritical helium, used for the cooling of SC magnets. The transients of the thermal energy pulses can be attenuated in the cryogenic distribution system by various methodologies. One of the adopted methodologies in the present study is with the precise speed control of the cold circulators. The adopted methodology is applied to various configurations of arrangements of internal components in the distribution system for obtaining system responses with superior attenuation of energy pulses. The process simulation approach, assumptions, considered inputs and constraints, process modeling with different configuration as well as results to accomplish the control scheme for the attenuation of the thermal energy pulses are described.

  4. Effect of Fuelling Depth on the Fusion Performance and Particle Confinement of a Fusion Reactor

    Science.gov (United States)

    Wang, Shijia; Wang, Shaojie

    2016-12-01

    The fusion performance and particle confinement of an international thermonuclear experimental reactor (ITER)-like fusion device have been modeled by numerically solving the energy transport equation and the particle transport equation. The effect of fuelling depth has been investigated. The plasma is primarily heated by the fusion produced alpha particles and the loss process of particles and energy in the scrape-off layer has been taken into account. To study the effect of fuelling depth on fusion performance, the ITERH-98P(y,2) scaling law has been used to evaluate the transport coefficients. It is shown that the particle confinement and fusion performance are significantly dependent on the fuelling depth. Deviation of 10% of the minor radius on fuelling depth can make the particle confinement change by ∼ 61% and the fusion performance change by ∼ 108%. The enhancement of fusion performance is due to the better particle confinement induced by deeper particle fuelling. supported by National Natural Science Foundation of China (Nos. 11175178 and 11375196) and the National Magnetic Confinement Fusion Science Program of China (No. 2014GB113000)

  5. ALPHA MIS: Reference manual

    Energy Technology Data Exchange (ETDEWEB)

    Lovin, J.K.; Haese, R.L.; Heatherly, R.D.; Hughes, S.E.; Ishee, J.S.; Pratt, S.M.; Smith, D.W.

    1992-02-01

    ALPHA is a powerful and versatile management information system (MIS) initiated and sponsored and by the Finance and Business Management Division of Oak Ridge National Laboratory, who maintain and develop it in concert with the Business Systems Division for its Information Center. A general-purpose MIS, ALPHA allows users to access System 1022 and System 1032 databases to obtain and manage information. From a personal computer or a data terminal, Energy Systems employees can use ALPHA to control their own report reprocessing. Using four general commands (Database, Select, Sort, and Report) they can (1) choose a mainframe database, (2) define subsets within it, (3) sequentially order a subset by one or more variables, and (4) generate a report with their own or a canned format.

  6. The effect of alpha-linolenic acid supplementation on ADHD symptoms in children: a randomized controlled double-blind study

    Directory of Open Access Journals (Sweden)

    Gal eDubnov-Raz

    2014-10-01

    Full Text Available Background: Attention Deficit-Hyperactivity Disorder (ADHD is the most common neuro-developmental disorder in childhood. Its pharmacologic treatment mostly includes methylphenidate, yet many parents seek alternative, natural, therapeutic options, commonly omega-3 fatty acids. Previous studies of supplementation with fish oil or long-chain omega-3 fatty acids to children with ADHD yielded mixed results. The use of alpha-linolenic acid, a medium-chained, plant-based omega-3 fatty acid (18:3 n-3, has not been sufficiently examined in this population. Methods: Forty untreated children with ADHD, aged 6-16 years, were randomized to receive either 2gr/day of oil containing 1gr alpha-linolenic acid or placebo, for 8 weeks. Before and after supplementation, the children underwent a physician assessment of ADHD symptoms and a computerized continuous performance functions test. The children's parents and teachers filled out Conners' and DSM questionnaires. Results: Seventeen (42.5% children completed the study, 8 in the supplementation group, 9 in the placebo group. Main drop-out reasons were capsule size, poor compliance, and a sense of lack of effect. No significant difference was found in any of the measured variables tested before and after supplementation, in both study groups. No between-group difference was found in the changes of the various measures of ADHD symptoms throughout the study period.Conclusion: Supplementation of 2gr/day of oil containing 1gr alpha-linolenic acid did not significantly reduce symptoms in children with ADHD. Future studies in this field should consider an alternative method to deliver the oil, a higher dose, and a larger sample size.

  7. Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

    DEFF Research Database (Denmark)

    Porse, Bo T; Bryder, David; Theilgaard-Mönch, Kim;

    2005-01-01

    CCAAT/enhancer binding protein (C/EBP)alpha is a myeloid-specific transcription factor that couples lineage commitment to terminal differentiation and cell cycle arrest, and is found mutated in 9% of patients who have acute myeloid leukemia (AML). We previously showed that mutations which......, accumulation of myeloblasts and promyelocytes, and expansion of myeloid progenitor populations--all characteristics of AML. Circulating myeloblasts and hepatic leukocyte infiltration were observed, but thrombocytopenia, anemia, and elevated leukocyte count--normally associated with AML-were absent...

  8. Fluorescent Protein Approaches in Alpha Herpesvirus Research

    Directory of Open Access Journals (Sweden)

    Ian B. Hogue

    2015-11-01

    Full Text Available In the nearly two decades since the popularization of green fluorescent protein (GFP, fluorescent protein-based methodologies have revolutionized molecular and cell biology, allowing us to literally see biological processes as never before. Naturally, this revolution has extended to virology in general, and to the study of alpha herpesviruses in particular. In this review, we provide a compendium of reported fluorescent protein fusions to herpes simplex virus 1 (HSV-1 and pseudorabies virus (PRV structural proteins, discuss the underappreciated challenges of fluorescent protein-based approaches in the context of a replicating virus, and describe general strategies and best practices for creating new fluorescent fusions. We compare fluorescent protein methods to alternative approaches, and review two instructive examples of the caveats associated with fluorescent protein fusions, including describing several improved fluorescent capsid fusions in PRV. Finally, we present our future perspectives on the types of powerful experiments these tools now offer.

  9. Energy-sensing Factors Coactivator Peroxisome Proliferator-activated Receptor gamma Coactivator 1-alpha (PGC-1 alpha) and AMP-activated Protein Kinase Control Expression of Inflammatory Mediators in Liver INDUCTION OF INTERLEUKIN 1 RECEPTOR ANTAGONIST

    NARCIS (Netherlands)

    Buler, M.; Aatsinki, S.M.; Skoumal, R.; Komka, Z.; Toth, M.; Kerkela, R.; Georgiadi, A.; Kersten, A.H.; Hakkola, J.

    2012-01-01

    Obesity and insulin resistance are associated with chronic, low grade inflammation. Moreover, regulation of energy metabolism and immunity are highly integrated. We hypothesized that energy-sensitive coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) and A

  10. Inertial-confinement fusion with lasers

    Science.gov (United States)

    Betti, R.; Hurricane, O. A.

    2016-05-01

    The quest for controlled fusion energy has been ongoing for over a half century. The demonstration of ignition and energy gain from thermonuclear fuels in the laboratory has been a major goal of fusion research for decades. Thermonuclear ignition is widely considered a milestone in the development of fusion energy, as well as a major scientific achievement with important applications in national security and basic sciences. The US is arguably the world leader in the inertial confinement approach to fusion and has invested in large facilities to pursue it, with the objective of establishing the science related to the safety and reliability of the stockpile of nuclear weapons. Although significant progress has been made in recent years, major challenges still remain in the quest for thermonuclear ignition via laser fusion. Here, we review the current state of the art in inertial confinement fusion research and describe the underlying physical principles.

  11. 2003 activity report of the development and research line in controlled thermonuclear fusion of the Plasma Associated Laboratory; Relatorio de atividades de 2003 da linha de pesquisa e desenvolvimento em fusao termonuclear controlada - fusao. Laboratorio Associado de Plasma (LAP)

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, Gerson Otto

    2004-07-01

    This document represents the 2003 activity report of the development and research line in controlled thermonuclear fusion of the Plasma Associated Laboratory - Brazil, approaching the areas of toroidal systems for magnetic confinement, plasma heating, current generation and high temperature plasma diagnostic.

  12. 2001 activity report of the development and research line in controlled thermonuclear fusion of the Plasma Associated Laboratory; Relatorio de atividades de 2001 da linha de pesquisa e desenvolvimento em fusao termonuclear controlada (fusao), do Laboratorio Associado de Plasma (LAP)

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, Gerson Otto

    2002-07-01

    The year 2001 activities of the controlled thermonuclear fusion research line of the Plasma Associated Laboratory at the National Institute for Space Research - Brazil are reported. The report approaches the staff, participation in congresses, goals for the year 2002 and papers on Tokamak plasmas, plasma diagnostic, bootstraps, plasma equilibrium and diagnostic.

  13. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease.

    Science.gov (United States)

    Shinto, Lynne; Quinn, Joseph; Montine, Thomas; Dodge, Hiroko H; Woodward, William; Baldauf-Wagner, Sara; Waichunas, Dana; Bumgarner, Lauren; Bourdette, Dennis; Silbert, Lisa; Kaye, Jeffrey

    2014-01-01

    Oxidative stress, inflammation, and increased cholesterol levels are all mechanisms that have been associated with Alzheimer's disease (AD) pathology. Several epidemiologic studies have reported a decreased risk of AD with fish consumption. This pilot study was designed to evaluate the effects of supplementation with omega-3 fatty acids alone (ω-3) or omega-3 plus alpha lipoic acid (ω-3 + LA) compared to placebo on oxidative stress biomarkers in AD. The primary outcome measure was peripheral F2-isoprostane levels (oxidative stress measure). Secondary outcome measures included performance on: Mini-Mental State Examination (MMSE), Activities of Daily Living/Instrumental Activities of Daily Living (ADL/IADL), and Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-cog). Thirty-nine AD subjects were randomized to one of three groups: 1) placebo, 2) ω-3, or 3) ω-3 + LA for a treatment duration of 12 months. Eighty seven percent (34/39) of the subjects completed the 12-month intervention. There was no difference between groups at 12 months in peripheral F2-isoprostane levels (p = 0.83). The ω-3 + LA and ω-3 were not significantly different than the placebo group in ADAS-cog (p = 0.98, p = 0.86) and in ADL (p = 0.15, p = 0.82). Compared to placebo, the ω-3 + LA showed less decline in MMSE (p omega-3 fatty acids plus alpha-lipoic acid as a potential treatment in AD is warranted.

  14. Venous responses during exercise in rainbow trout, Oncorhynchus mykiss: alpha-adrenergic control and the antihypotensive function of the renin-angiotensin system.

    Science.gov (United States)

    Sandblom, Erik; Axelsson, Michael; McKenzie, David J

    2006-08-01

    The role of the alpha-adrenergic system in the control of cardiac preload (central venous blood pressure; P(ven)) and venous capacitance during exercise was investigated in rainbow trout (Oncorhynchus mykiss). In addition, the antihypotensive effect of the renin-angiotesin system (RAS) was investigated during exercise after alpha-adrenoceptor blockade. Fish were subjected to a 20-min exercise challenge at 0.66 body lengths s(-1) (BL s(-1)) while P(ven), dorsal aortic blood pressure (P(da)) and relative cardiac output (Q) was recorded continuously. Heart rate (f(H)), cardiac stroke volume (SV) and total systemic resistance (R(sys)) were derived from these variables. The mean circulatory filling pressure (MCFP) was measured at rest and at the end of the exercise challenge, to investigate potential exercise-mediated changes in venous capacitance. The protocol was repeated after alpha-adrenoceptor blockade with prazosin (1 mg kg(-1)M(b)) and again after additional blockade of angiotensin converting enzyme (ACE) with enalapril (1 mg kg(-1)M(b)). In untreated fish, exercise was associated with a rapid (within approx. 1-2 min) and sustained increase in Q and P(ven) associated with a significant increase in MCFP (0.17+/-0.02 kPa at rest to 0.27+/-0.02 kPa at the end of exercise). Prazosin treatment did not block the exercise-mediated increase in MCFP (0.25+/-0.04 kPa to 0.33+/-0.04 kPa at the end of exercise), but delayed the other cardiovascular responses to swimming such that Q and P(ven) did not increase significantly until around 10-13 min of exercise, suggesting that an endogenous humoral control mechanism had been activated. Subsequent enalapril treatment revealed that these delayed responses were in fact due to activation of the RAS, because resting P(da) and R(sys) were decreased further and essentially all cardiovascular changes during exercise were abolished. This study shows that the alpha-adrenergic system normally plays an important role in the control of

  15. Tracking Control of Mobile Robots Localized via Chained Fusion of Discrete and Continuous Epipolar Geometry, IMU and Odometry.

    Science.gov (United States)

    Tick, David; Satici, Aykut C; Shen, Jinglin; Gans, Nicholas

    2013-08-01

    This paper presents a novel navigation and control system for autonomous mobile robots that includes path planning, localization, and control. A unique vision-based pose and velocity estimation scheme utilizing both the continuous and discrete forms of the Euclidean homography matrix is fused with inertial and optical encoder measurements to estimate the pose, orientation, and velocity of the robot and ensure accurate localization and control signals. A depth estimation system is integrated in order to overcome the loss of scale inherent in vision-based estimation. A path following control system is introduced that is capable of guiding the robot along a designated curve. Stability analysis is provided for the control system and experimental results are presented that prove the combined localization and control system performs with high accuracy.

  16. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control.

    Science.gov (United States)

    Barrett, Marilyn L; Udani, Jay K

    2011-03-17

    Obesity, and resultant health hazards which include diabetes, cardiovascular disease and metabolic syndrome, are worldwide medical problems. Control of diet and exercise are cornerstones of the management of excess weight. Foods with a low glycemic index may reduce the risk of diabetes and heart disease as well as their complications. As an alternative to a low glycemic index diet, there is a growing body of research into products that slow the absorption of carbohydrates through the inhibition of enzymes responsible for their digestion. These products include alpha-amylase and glucosidase inhibitors. The common white bean (Phaseolus vulgaris) produces an alpha-amylase inhibitor, which has been characterized and tested in numerous clinical studies. A specific and proprietary product named Phase 2® Carb Controller (Pharmachem Laboratories, Kearny, NJ) has demonstrated the ability to cause weight loss with doses of 500 to 3000 mg per day, in either a single dose or in divided doses. Clinical studies also show that Phase 2 has the ability to reduce the post-prandial spike in blood glucose levels. Experiments conducted incorporating Phase 2 into food and beverage products have found that it can be integrated into various products without losing activity or altering the appearance, texture or taste of the food. There have been no serious side effects reported following consumption of Phase 2. Gastro-intestinal side effects are rare and diminish upon extended use of the product. In summary, Phase 2 has the potential to induce weight loss and reduce spikes in blood sugar caused by carbohydrates through its alpha-amylase inhibiting activity.

  17. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris: A review of clinical studies on weight loss and glycemic control

    Directory of Open Access Journals (Sweden)

    Barrett Marilyn L

    2011-03-01

    Full Text Available Abstract Obesity, and resultant health hazards which include diabetes, cardiovascular disease and metabolic syndrome, are worldwide medical problems. Control of diet and exercise are cornerstones of the management of excess weight. Foods with a low glycemic index may reduce the risk of diabetes and heart disease as well as their complications. As an alternative to a low glycemic index diet, there is a growing body of research into products that slow the absorption of carbohydrates through the inhibition of enzymes responsible for their digestion. These products include alpha-amylase and glucosidase inhibitors. The common white bean (Phaseolus vulgaris produces an alpha-amylase inhibitor, which has been characterized and tested in numerous clinical studies. A specific and proprietary product named Phase 2® Carb Controller (Pharmachem Laboratories, Kearny, NJ has demonstrated the ability to cause weight loss with doses of 500 to 3000 mg per day, in either a single dose or in divided doses. Clinical studies also show that Phase 2 has the ability to reduce the post-prandial spike in blood glucose levels. Experiments conducted incorporating Phase 2 into food and beverage products have found that it can be integrated into various products without losing activity or altering the appearance, texture or taste of the food. There have been no serious side effects reported following consumption of Phase 2. Gastro-intestinal side effects are rare and diminish upon extended use of the product. In summary, Phase 2 has the potential to induce weight loss and reduce spikes in blood sugar caused by carbohydrates through its alpha-amylase inhibiting activity.

  18. A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression.

    Science.gov (United States)

    Laganière, Josée; Tremblay, Gilles B; Dufour, Catherine R; Giroux, Sylvie; Rousseau, François; Giguère, Vincent

    2004-04-30

    The orphan nuclear estrogen-related receptor alpha (ERRalpha) and transcriptional cofactor peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) are involved in the regulation of energy metabolism. Recently, extensive cross-talk between PGC-1alpha and ERRalpha has been demonstrated. The presence of PGC-1alpha is associated with an elevated expression of ERRalpha, and the two proteins can influence the transcriptional activities of one another. Using a candidate gene approach to detect regulatory variants within genes encoding nuclear receptors, we have identified a 23-bp sequence (ESRRA23) containing two nuclear receptor recognition half-site motifs that is present in 1-4 copies within the promoter of the human ESRRA gene encoding ERRalpha. The ESRRA23 sequence contains a functional ERR response element that is specifically bound by ERRalpha, and chromatin immunoprecipitation shows that endogenous ERRalpha occupies its own promoter in vivo. Strikingly, introduction of PGC-1alpha in HeLa cells by transient transfection induces the activity of the ESRRA promoter in a manner that is dependent on the presence of the ESRRA23 element and on its dosage. Coexpression of ERRalpha and PGC-1alpha results in a synergistic activation of the ESRRA promoter. In experiments using ERRalpha null fibroblasts, the ability of PGC-1alpha to stimulate the ESRRA promoter is considerably reduced but can be restored by addition of ERRalpha. Taken together, these results demonstrate that an interdependent ERRalpha/PGC-1alpha-based transcriptional pathway targets the ESRRA23 element to dictate the level of ERRalpha expression. This study further suggests that this regulatory polymorphism may provide differential responses to ERRalpha/PGC-1alpha-mediated metabolic cues in the human population.

  19. Mass Producing Targets for Nuclear Fusion

    Science.gov (United States)

    Wang, T. G.; Elleman, D. D.; Kendall, J. M.

    1983-01-01

    Metal-encapsulating technique advances prospects of controlling nuclear fusion. Prefilled fusion targets form at nozzle as molten metal such as tin flows through outer channel and pressurized deuterium/tritium gas flows through inner channel. Molten metal completely encloses gas charge as it drops off nozzle.

  20. A role for arabinogalactan proteins in gibberellin-induced alpha-amylase production in barley aleurone cells.

    Science.gov (United States)

    Suzuki, Yoshihito; Kitagawa, Mamiko; Knox, J Paul; Yamaguchi, Isomaro

    2002-03-01

    Arabinogalactan proteins (AGPs) are plant proteoglycans that have been implicated in plant growth and development. The possible involvement of AGPs in the action of gibberellin (GA), a class of plant hormones, was examined by applying beta-glucosyl Yariv reagent (beta-Glc)3Y, a synthetic phenyl glycoside that interacts selectively with AGPs, to barley aleurone protoplasts. Gibberellin induces transcription and secretion of alpha-amylases in the protoplasts. Induction of alpha-amylase was clearly inhibited by (beta-Glc)3Y but not by (alpha-Gal)3Y, a negative control of the Yariv reagent that does not interact with AGPs. Transfection analysis, using an alpha-amylase promoter-GUS fusion gene in the protoplasts, indicated that the transcriptional activation of the alpha-amylase promoter was inhibited specifically by (beta-Glc)3Y. These observations are the first indication of an involvement of AGPs in a plant hormone function. The inhibitory effect of (beta-Glc)3Y was not observed when aleurone layers or half-seed grains were used. This result, together with the fact that protoplasts do not have cell walls, suggests that the AGPs that function in alpha-amylase induction reside at the plasma membrane. An aleurone-specific AGP was detected by reversed-phase HPLC, and supported the idea that an AGP may play an important role in aleurone-specific events. The possible mechanism of AGP function in gibberellin-induced alpha-amylase production is discussed.

  1. Computational model of thalamo-cortical networks: dynamical control of alpha rhythms in relation to focal attention.

    Science.gov (United States)

    Suffczynski, P; Kalitzin, S; Pfurtscheller, G; Lopes da Silva, F H

    2001-12-01

    EEG/MEG rhythmic activities such as alpha rhythms, of the visual or of the somato-sensory cortex, are commonly modulated as subjects perform certain tasks or react to specific stimuli. In general, these activities change depending on extrinsic or intrinsic events. A decrease of the amplitude of alpha rhythmic activity occurring after a given event, which manifests as a decrease of a spectral peak, is called event-related desynchronization (ERD), whereas the inverse is called event-related synchronization (ERS), since it is assumed that the power of a spectral peak is related to the degree of synchrony of the underlying oscillating neuronal populations. An intriguing observation in this respect [Pfurtscheller and Neuper, Neurosci. Lett. 174 (1994) 93-96] was that ERD of alpha rhythms recorded over the central areas was accompanied by ERS, within the same frequency band, recorded over neighboring areas. In case the event was a hand movement, ERD was recorded over the scalp overlying the hand cortical area, whereas ERS was concomitantly recorded over the midline, whereas if the movement was of the foot the opposite was found. We called this phenomenon 'focal ERD/surround ERS'. The question of how this phenomenon may be generated was approached by means of a computational model of thalamo-cortical networks, that incorporates basic properties of neurons and synaptic interactions. These simulation studies revealed that this antagonistic ERD/ERS phenomenon depends on the functional interaction between the populations of thalamo-cortical cells (TCR) and reticular nucleus cells (RE) and on how this interaction is modulated by cholinergic inputs. An essential feature of this interaction is the existence of cross-talk between different sectors of RE that correspond to distinct sensory modules (e.g. hand, foot). These observations led us to formulate the hypothesis that this basic neurophysiological mechanism can account for the general observation that enhanced attention

  2. Effectiveness of Alpha Biofeedback Therapy: Negative Results.

    Science.gov (United States)

    Watson, Charles G.; Herder, Joseph

    1980-01-01

    Assessed the utility of alpha biofeedback training in the treatment of patients (N=66). Biofeedback and placebo biofeedback groups were given alpha or mock-alpha training sessions. Improvement on 54 variables was compared to that of no-treatment controls. Only a chance number of significant changes appeared among the groups. (Author)

  3. Measurements of DT alpha particle loss near the outer midplane of TFTR

    Energy Technology Data Exchange (ETDEWEB)

    Zweben, S.J.; Darrow, D.S.; Herrmann, H.W.; Redi, M.H.; Schivell, J.; White, R.B.

    1995-07-01

    Measurements of DT alpha particle loss to the outer midplane region of TFTR have been made using a radially movable scintillator detector. The conclusion from this data is that mechanisms determining the DT alpha loss to the outer midplane are not substantially different from those for DD fusion products. Some of these results are compared with a simplified theoretical model for TF ripple-induced alpha loss, which is expected to be the dominant classical alpha loss mechanism near the outer midplane. An example of plasma-driven MHD-induced alpha particle loss is shown, but no signs of any ``collective`` alpha instability-induced alpha loss have yet been observed.

  4. Adsorption-controlled transition of the electrical properties realized in Hematite (alpha-Fe2O3)nanorods ethanol sensing

    Institute of Scientific and Technical Information of China (English)

    Wang Chong; Wang Fei-Fei; Fu Xing-Qiu; Zhang En-Di; Xu Zhi

    2011-01-01

    Alpha-Fe2O3 nanorods are synthesized through a hydrothermal method with no surfactant introduced and ethanol sensors are fabricated from these nanorods. The device can respond to ethanol vapour in a concentration range from 1to 1500 parts per million and shows both p-type and n-type responding characteristics during the investigation of the ethanol sensing. The sensor displays a p-type characteristic when the ethanol concentration is low and converted into an n-type characteristic as the concentration exceeds a certain value. Such a phenomenon is attributed to the chemisorbed oxygen, which leads to different modifications of the energy band at the surface, namely, depletion layer or inversion layer.

  5. 基于SmartFusion的无人机飞行控制系统设计%Design of SmartFusion-based flight control system for UAVs

    Institute of Scientific and Technical Information of China (English)

    王昱辉; 雷金奎; 田力

    2012-01-01

    为了使无人机飞行控制系统具有强大的数据处理能力、较低的功耗、较强的灵活性和更高的集成度,提出了一种以SmartFusion为核心的无人机飞行控制系统解决方案.为满足飞控系统实时性和稳定性的要求,系统采用了μC/OS-Ⅱ实时操作系统.与传统的无人机飞行控制系统相比,在具有很强的数据处理能力的同时拥有较小的体积和较低的功耗.多次飞行证明,各个模块设计合理,整个系统运行稳定,可以用作下一代无人机高性能应用平台.%In order to make the unmanned aerial vehicle flight control system has the formidable data-processing capacity, low power consumption* strong flexibility and small volume, a solution of unmanned aerial vehicle flight control system based on SmartFusion is proposed. The real-time opereational system (RTOS) pC /OS- II is adopted in the system to meet the realtime and stability needs of the flight control system. Compared with the control system of traditional unmanned aerial vehicle, it has higher integration and lower power consumption while having stronger data-handling capacity. The several flights prove that each modular design is reasonable, the overall system works stably, and the control system may serve as a high performance application platform for the next generation unmanned aerial vehicle.

  6. Doppler tomography in fusion plasmas and astrophysics

    CERN Document Server

    Salewski, Mirko; Heidbrink, Bill; Jacobsen, Asger Schou; Korsholm, Soren Bang; Leipold, Frank; Madsen, Jens; Moseev, Dmitry; Nielsen, Stefan Kragh; Rasmussen, Jesper; Stagner, Luke; Steeghs, Danny; Stejner, Morten; Tardini, Giovani; Weiland, Markus

    2015-01-01

    Doppler tomography is a well-known method in astrophysics to image the accretion flow, often in the shape of thin discs, in compact binary stars. As accretion discs rotate, all emitted line radiation is Doppler-shifted. In fast-ion D-alpha (FIDA) spectroscopy measurements in magnetically confined plasma, the D-alpha-photons are likewise Doppler-shifted ultimately due to gyration of the fast ions. In either case, spectra of Doppler-shifted line emission are sensitive to the velocity distribution of the emitters. Astrophysical Doppler tomography has lead to images of accretion discs of binaries revealing bright spots, spiral structures, and flow patterns. Fusion plasma Doppler tomography has lead to an image of the fast-ion velocity distribution function in the tokamak ASDEX Upgrade. This image matched numerical simulations very well. Here we discuss achievements of the Doppler tomography approach, its promise and limits, analogies and differences in astrophysical and fusion plasma Doppler tomography, and what ...

  7. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis.

    Science.gov (United States)

    Naiki, Yoshikazu; Sorrentino, Rosalinda; Wong, Michelle H; Michelsen, Kathrin S; Shimada, Kenichi; Chen, Shuang; Yilmaz, Atilla; Slepenkin, Anatoly; Schröder, Nicolas W J; Crother, Timothy R; Bulut, Yonca; Doherty, Terence M; Bradley, Michelle; Shaposhnik, Zory; Peterson, Ellena M; Tontonoz, Peter; Shah, Prediman K; Arditi, Moshe

    2008-11-15

    Experimental and clinical studies link Chlamydia pneumoniae infection to atherogenesis and atherothrombotic events, but the underlying mechanisms are unclear. We tested the hypothesis that C. pneumoniae-induced acceleration of atherosclerosis in apolipoprotein E (ApoE)(-/-) mice is reciprocally modulated by activation of TLR-mediated innate immune and liver X receptor alpha (LXRalpha) signaling pathways. We infected ApoE(-/-) mice and ApoE(-/-) mice that also lacked TLR2, TLR4, MyD88, or LXRalpha intranasally with C. pneumoniae followed by feeding of a high fat diet for 4 mo. Mock-infected littermates served as controls. Atherosclerosis was assessed in aortic sinuses and in en face preparation of whole aorta. The numbers of activated dendritic cells (DCs) within plaques and the serum levels of cholesterol and proinflammatory cytokines were also measured. C. pneumoniae infection markedly accelerated atherosclerosis in ApoE-deficient mice that was associated with increased numbers of activated DCs in aortic sinus plaques and higher circulating levels of MCP-1, IL-12p40, IL-6, and TNF-alpha. In contrast, C. pneumoniae infection had only a minimal effect on atherosclerosis, accumulation of activated DCs in the sinus plaques, or circulating cytokine increases in ApoE(-/-) mice that were also deficient in TLR2, TLR4, or MyD88. However, C. pneumoniae-induced acceleration of atherosclerosis in ApoE(-/-) mice was further enhanced in ApoE(-/-)LXRalpha(-/-) double knockout mice and was accompanied by higher serum levels of IL-6 and TNF-alpha. We conclude that C. pneumoniae infection accelerates atherosclerosis in hypercholesterolemic mice predominantly through a TLR/MyD88-dependent mechanism and that LXRalpha appears to reciprocally modulate and reduce the proatherogenic effects of C. pneumoniae infection.

  8. Two heretical thoughts on fusion and climate

    Science.gov (United States)

    Manheimer, Wallace

    2016-10-01

    This presents and explores 2 heretical thoughts regarding controlled fusion and climate. First, the only way that fusion can contribute to midcentury power is by switching its goal from pure fusion, to fusion breeding. Fusion breeding makes many fewer demands on the fusion device than does pure fusion. Fusion breeding could lead to a sustainable, carbon free, environmentally and economically viable, midcentury infrastructure, with little or no proliferation risk, which could provide terawatts of power for the world. The second involves climate. We are all inundated by media warnings, not only of warming from CO2 in the atmosphere, but all sorts of other environmental disasters. For instance there will be more intense storms, rising sea levels, wild fires, retreating glaciers, droughts, loss of agricultural productivity... These assertions are very easy to check out. Such a search shows that we are nowhere near any sort of environmental crisis. The timing could be serendipitous; the time necessary to develop fusion breeding could well match up to the time when it is needed so as to avoid harm to the earth's climate and/or depletion of finite energy resources.

  9. Proteinaceous alpha-araylase inhibitors

    DEFF Research Database (Denmark)

    Svensson, Birte; Fukuda, Kenji; Nielsen, P.K.

    2004-01-01

    Proteins that inhibit alpha-amylases have been isolated from plants and microorganisms. These inhibitors can have natural roles in the control of endogenous a-amylase activity or in defence against pathogens and pests; certain inhibitors are reported to be antinutritional factors. The alpha-amylase...... inhibitors belong to seven different protein structural families, most of which also contain evolutionary related proteins without inhibitory activity. Two families include bifunctional inhibitors acting both on alpha-amylases and proteases. High-resolution structures are available of target alpha-amylases...... in complex with inhibitors from five families. These structures indicate major diversity but also some similarity in the structural basis of alpha-amylase inhibition. Mutational analysis of the mechanism of inhibition was performed in a few cases and various protein engineering and biotechnological...

  10. Alloy Design for a Fusion Power Plant

    OpenAIRE

    Kemp, Richard

    2006-01-01

    Fusion power is generated when hot deuterium and tritium nuclei react, producing alpha particles and 14 MeV neutrons. These neutrons escape the reaction plasma and are absorbed by the surrounding material structure of the plant, transferring the heat of the reaction to an external cooling circuit. In such high-energy neutron irradiation environments, extensive atomic displacement damage and transmutation production of helium affect the mechanical properties of materials. Among these effect...

  11. Alpha Channeling in a Rotating Plasma

    Energy Technology Data Exchange (ETDEWEB)

    Abraham J. Fetterman and Nathaniel J. Fisch

    2008-09-23

    The wave-particle α-channeling effect is generalized to include rotating plasma. Specifically, radio frequency waves can resonate with α particles in a mirror machine with E × B rotation to diffuse the α particles along constrained paths in phase space. Of major interest is that the α-particle energy, in addition to amplifying the RF waves, can directly enhance the rotation energy which in turn provides additional plasma confinement in centrifugal fusion reactors. An ancillary benefit is the rapid removal of alpha particles, which increases the fusion reactivity.

  12. Early versus late initiation of rehabilitation after lumbar spinal fusion: economic evaluation alongside a randomized controlled trial

    DEFF Research Database (Denmark)

    Østergaard, Lisa G.; Christensen, Finn B.; Nielsen, Claus V.

    2013-01-01

    STUDY DESIGN: Economic evaluation conducted alongside a randomized controlled trial with 1-year follow-up. OBJECTIVE: To examine the cost-effectiveness of initiating rehabilitation 6 weeks after surgery as opposed to 12 weeks after surgery. SUMMARY OF BACKGROUND DATA: In a previously reported ran...

  13. Fusion Power Program. Quarterly progress report, October--December 1978

    Energy Technology Data Exchange (ETDEWEB)

    1979-04-01

    This quarterly report summarizes the Argonne National Laboratory work performed for the Office of Fusion Energy during the October--December 1978 quarter in the following research and development areas: materials; energy storage and transfer; tritium containment, recovery and control; advanced reactor design; atomic data; reactor safety; fusion-fission hybrid systems; alternate applications of fusion energy; and other work related to fusion power. Three separate abstracts were prepared for the included sections. (MOW)

  14. Fusion Power Program biannual progress report, April-September 1979

    Energy Technology Data Exchange (ETDEWEB)

    1980-02-01

    This biannual report summarizes the Argonne National Laboratory work performed for the Office of Fusion Energy during the April-September 1979 quarter in the following research and development areas: materials; energy storage and transfer; tritium containment, recovery and control; advanced reactor design; atomic data; reactor safety; fusion-fission hybrid systems; alternate applications of fusion energy; and other work related to fusion power. Separate abstracts were prepared for three sections. (MOW)

  15. Cold fusion research

    Energy Technology Data Exchange (ETDEWEB)

    None

    1989-11-01

    I am pleased to forward to you the Final Report of the Cold Fusion Panel. This report reviews the current status of cold fusion and includes major chapters on Calorimetry and Excess Heat, Fusion Products and Materials Characterization. In addition, the report makes a number of conclusions and recommendations, as requested by the Secretary of Energy.

  16. Cdc42 and Actin Control Polarized Expression of TI-VAMP Vesicles to Neuronal Growth Cones and Their Fusion with the Plasma MembraneV⃞

    Science.gov (United States)

    Alberts, Philipp; Rudge, Rachel; Irinopoulou, Theano; Danglot, Lydia; Gauthier-Rouvière, Cécile; Galli, Thierry

    2006-01-01

    Tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP)-mediated fusion of intracellular vesicles with the plasma membrane is crucial for neurite outgrowth, a pathway not requiring synaptobrevin-dependent exocytosis. Yet, it is not known how the TI-VAMP membrane trafficking pathway is regulated or how it is coordinated with cytoskeletal dynamics within the growth cone that guide neurite outgrowth. Here, we demonstrate that TI-VAMP, but not synaptobrevin 2, concentrates in the peripheral, F-actin-rich region of the growth cones of hippocampal neurons in primary culture. Its accumulation correlates with and depends upon the presence of F-actin. Moreover, acute stimulation of actin remodeling by homophilic activation of the adhesion molecule L1 induces a site-directed, actin-dependent recruitment of the TI-VAMP compartment. Expression of a dominant-positive mutant of Cdc42, a key regulator of cell polarity, stimulates formation of F-actin- and TI-VAMP-rich filopodia outside the growth cone. Furthermore, we report that Cdc42 activates exocytosis of pHLuorin tagged TI-VAMP in an actin-dependent manner. Collectively, our data suggest that Cdc42 and regulated assembly of the F-actin network control the accumulation and exocytosis of TI-VAMP-containing membrane vesicles in growth cones to coordinate membrane trafficking and actin remodeling during neurite outgrowth. PMID:16381811

  17. Cdc42 and actin control polarized expression of TI-VAMP vesicles to neuronal growth cones and their fusion with the plasma membrane.

    Science.gov (United States)

    Alberts, Philipp; Rudge, Rachel; Irinopoulou, Theano; Danglot, Lydia; Gauthier-Rouvière, Cécile; Galli, Thierry

    2006-03-01

    Tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP)-mediated fusion of intracellular vesicles with the plasma membrane is crucial for neurite outgrowth, a pathway not requiring synaptobrevin-dependent exocytosis. Yet, it is not known how the TI-VAMP membrane trafficking pathway is regulated or how it is coordinated with cytoskeletal dynamics within the growth cone that guide neurite outgrowth. Here, we demonstrate that TI-VAMP, but not synaptobrevin 2, concentrates in the peripheral, F-actin-rich region of the growth cones of hippocampal neurons in primary culture. Its accumulation correlates with and depends upon the presence of F-actin. Moreover, acute stimulation of actin remodeling by homophilic activation of the adhesion molecule L1 induces a site-directed, actin-dependent recruitment of the TI-VAMP compartment. Expression of a dominant-positive mutant of Cdc42, a key regulator of cell polarity, stimulates formation of F-actin- and TI-VAMP-rich filopodia outside the growth cone. Furthermore, we report that Cdc42 activates exocytosis of pHLuorin tagged TI-VAMP in an actin-dependent manner. Collectively, our data suggest that Cdc42 and regulated assembly of the F-actin network control the accumulation and exocytosis of TI-VAMP-containing membrane vesicles in growth cones to coordinate membrane trafficking and actin remodeling during neurite outgrowth.

  18. Comparative study of the efficacy of transdermal buprenorphine patches and prolonged-release tramadol tablets for postoperative pain control after spinal fusion surgery: a prospective, randomized controlled non-inferiority trial.

    Science.gov (United States)

    Kim, Ho-Joong; Ahn, Hyo Sae; Nam, Yunjin; Chang, Bong-Soon; Lee, Choon-Ki; Yeom, Jin S

    2017-07-20

    To compare the efficacy of a transdermal buprenorphine patch (5, 10, 15, and 20 μg/h) with that of oral tramadol (150, 200, 250, and 300 mg) for postoperative pain control after single level spinal fusion surgery. The present study (ClinicalTrials.gov, number NCT02416804) was a prospective, randomized controlled non-inferiority trial designed to determine the efficacy of buprenorphine TDS for alleviating postoperative pain following patient controlled analgesia (PCA) in persons underwent a single level posterior lumbar interbody fusion surgery through 1:1 allocation. The primary outcome was the Visual Analog Pain Scale (VAS) score for postoperative back pain at 7 days after surgery. The non-inferior margin of the VAS was set at δ = 1.5 points. The VAS score (primary outcome) for postoperative back pain at 7 days after surgery in the Buprenorphine group was not inferior compared to the Tramadol group. The overall changes in VAS scores for postoperative pain during follow-up assessments over a 2-week period did not differ between both groups. However, the VAS scores for postoperative pain significantly improved with time after surgery in both groups. The patterns of changes in the VAS scores for postoperative pain during the follow-up period were not significantly different between the both groups. The efficacy of buprenorphine TDS was not inferior to that of oral tramadol medication for alleviating postoperative pain in the subacute period from 72 h after surgery, following PCA administration. In addition, adverse events were similar between both groups.

  19. Sensor Fusion of a Mobile Device to Control and Acquire Videos or Images of Coffee Branches and for Georeferencing Trees

    Directory of Open Access Journals (Sweden)

    Paula Jimena Ramos Giraldo

    2017-04-01

    Full Text Available Smartphones show potential for controlling and monitoring variables in agriculture. Their processing capacity, instrumentation, connectivity, low cost, and accessibility allow farmers (among other users in rural areas to operate them easily with applications adjusted to their specific needs. In this investigation, the integration of inertial sensors, a GPS, and a camera are presented for the monitoring of a coffee crop. An Android-based application was developed with two operating modes: (i Navigation: for georeferencing trees, which can be as close as 0.5 m from each other; and (ii Acquisition: control of video acquisition, based on the movement of the mobile device over a branch, and measurement of image quality, using clarity indexes to select the most appropriate frames for application in future processes. The integration of inertial sensors in navigation mode, shows a mean relative error of ±0.15 m, and total error ±5.15 m. In acquisition mode, the system correctly identifies the beginning and end of mobile phone movement in 99% of cases, and image quality is determined by means of a sharpness factor which measures blurriness. With the developed system, it will be possible to obtain georeferenced information about coffee trees, such as their production, nutritional state, and presence of plagues or diseases.

  20. Conflicting views on the membrane fusion machinery and the fusion pore

    DEFF Research Database (Denmark)

    Sørensen, Jakob B

    2009-01-01

    of the assembly of the fusogenic SNARE-complex. Here, I review conflicting views on the function of the core fusion machinery consisting of the SNAREs, Munc18, complexin, and synaptotagmin. Munc18 controls docking of vesicles to the plasma membrane and initial SNARE-complex assembly, whereas complexin...... and synaptotagmin cooperate in holding the SNARE complex in an intermediate release-ready or cocked state. Different effects of complexin and synaptotagmin shape the energy landscape for fusion and make final fusion calcium triggered. The final steps are fusion pore formation and expansion, which allow release...

  1. Hendra virus fusion protein transmembrane domain contributes to pre-fusion protein stability.

    Science.gov (United States)

    Webb, Stacy; Nagy, Tamas; Moseley, Hunter; Fried, Michael; Dutch, Rebecca Ellis

    2017-02-17

    Enveloped viruses utilize fusion (F) proteins studding the surface of the virus to facilitate membrane fusion with a target cell membrane. Fusion of the viral envelope with a cellular membrane is required for release of viral genomic material so the virus can ultimately reproduce and spread. To drive fusion, the F protein undergoes an irreversible conformational change, transitioning from a meta-stable pre-fusion conformation to a more thermodynamically stable post-fusion structure. Understanding the elements which control stability of the pre-fusion state and triggering to the post-fusion conformation is important for understanding F protein function. Mutations in F protein transmembrane (TM) domains implicated the TM domain in the fusion process, but the structural and molecular details in fusion remain unclear. Previously, analytical ultracentrifugation was utilized to demonstrate that isolated TM domains of Hendra virus F protein associate in a monomer-trimer equilibrium (Smith EC, et al. Trimeric transmembrane domain interactions in paramyxovirus fusion proteins. 2013. J Biol Chem. 288, 35726). To determine factors driving this association, 140 paramyxovirus F protein TM domain sequences were analyzed. A heptad repeat of β-branched residues was found and analysis of the Hendra virus F TM domain revealed a heptad repeat leucine-isoleucine zipper motif (LIZ). Replacement of the LIZ with alanine resulted in dramatically reduced TM-TM association. Mutation of the LIZ in the whole protein resulted in decreased protein stability, including pre-fusion conformation stability. Together our data suggest that the heptad repeat LIZ contributed to TM-TM association and is important for F protein function and pre-fusion stability.

  2. Multisensor Data Fusion for Automotive Engine Fault Diagnosis

    Institute of Scientific and Technical Information of China (English)

    王赟松; 褚福磊; 何永勇; 郭丹

    2004-01-01

    This paper describes mainly a decision-level data fusion technique for fault diagnosis for electronically controlled engines.Experiments on a SANTANA AJR engine show that the data fusion method provides good engine fault diagnosis.In data fusion methods, the data level fusion has small data preprocessing loads and high accuracy, but requires commensurate sensor data and has poor operational performance.The decision-level fusion based on Dempster-Shafer evidence theory can process noncommensurate data and has robust operational performance, reduces ambiguity, increases confidence, and improves system reliability, but has low fusion accuracy and high data preprocessing cost.The feature-level fusion provides good compromise between the above two methods, which becomes gradually mature.In addition, acquiring raw data is a precondition to perform data fusion, so the system for signal acquisition and processing for an automotive engine test is also designed by the virtual instrument technology.

  3. Fusion of electromyographic signals with proprioceptive sensor data in myoelectric pattern recognition for control of active transfemoral leg prostheses.

    Science.gov (United States)

    Delis, Alberto López; de Carvalho, João Luiz Azevedo; Borges, Geovany Araújo; de Siqueira Rodrigues, Suélia; dos Santos, Icaro; da Rocha, Adson Ferreira

    2009-01-01

    This paper presents a myoelectric knee joint angle estimation algorithm for control of active transfemoral prostheses, based on feature extraction and pattern classification. The feature extraction stage uses a combination of time domain and frequency domain methods (entropy of myoelectric signals and cepstral coefficients, respectively). Additionally, the methods are fused with data from proprioceptive sensors (gyroscopes), from which angular rate information is extracted using a Kalman filter. The algorithm uses a Levenberg-Marquardt neural network for estimating the intended knee joint angle. The proposed method is demonstrated in a normal volunteer, and the results are compared with pattern classification methods based solely on electromyographic data. The use of surface electromyographic signals and additional information related to proprioception improves the knee joint angle estimation precision and reduces estimation artifacts.

  4. Congruence-Incongruence Patterns in Alpha-1 Antitrypsin Deficiency Couples' Genetic Determinist Beliefs and Perceived Control over Genes: Implications for Clinical and Public Health Genomic Communication.

    Science.gov (United States)

    Parrott, Roxanne L; Smith, Rachel A; Hong, Soo Jung; Worthington, Amber

    2015-06-01

    Genomics makes possible the isolation of multiple genes as co-factors that increase, but do not determine, risk for many adult-onset medical conditions, including alpha-1 antitrypsin deficiency (AATD). Those diagnosed with an adult-onset medical condition, such as AATD, are often married and make decisions about testing and care as a couple. We examined genetic essentialist and threat beliefs, focusing on beliefs about the genetic contribution to disease susceptibility and severity, as well as perceptions of control related to genes and health for married couples (N =59), in which one spouse has been tested for genetic mutations associated with AATD. The intraclass correlation for spouses' beliefs about genetic essentialism was strong and statistically significant, but the associations for their other beliefs were not. Incongruence between AATD participants and their spouses regarding genes' influence on disease severity directly related to incongruent perceptions of control and genetic contribution to disease susceptibility. Results revealed an inverse relationship to AATD participants' perceptions of behavioral control and a direct relationship to their beliefs about genes' influence on disease severity. This suggests a pattern of incongruence in which AATD participants have low levels of perceived control over genes' influence on health and high levels of perceived genetic influence on disease severity compared to spouses. With public health communication efforts lagging behind the science of genomics, insights regarding the congruence or incongruence associated with married couples' beliefs about genes' influence on disease afford pathways to guide clinical and public health communication about genomics.

  5. N-Acetylcysteine Supplementation Controls Total Antioxidant Capacity, Creatine Kinase, Lactate, and Tumor Necrotic Factor-Alpha against Oxidative Stress Induced by Graded Exercise in Sedentary Men

    Directory of Open Access Journals (Sweden)

    Donrawee Leelarungrayub

    2011-01-01

    Full Text Available Aim of this study was to evaluate the effects of short-term (7 days N-acetylcysteine (NAC at 1,200 mg daily supplementation on muscle fatigue, maximal oxygen uptake (VO2max, total antioxidant capacity (TAC, lactate, creatine kinase (CK, and tumor necrotic factor-alpha (TNF-α. Twenty-nine sedentary men (13 controls; 16 in the supplement group from a randomized control were included. At before and after supplementation, fatigue index (FI was evaluated in the quadriceps muscle, and performed a graded exercise treadmill test to induce oxidative stress, and as a measure of VO2max. Blood samples were taken before exercise and 20 minutes after it at before and after supplementation, to determine TAC, CK, lactate, and TNF-α levels. Results showed that FI and VO2max increased significantly in the supplement group. After exercise decreased the levels of TAC and increased lactate, CK, and TNF-α of both groups at before supplementation. After supplementation, lactate, CK, and TNF-α levels significantly increased and TAC decreased after exercise in the control group. Whereas the TAC and lactate levels did not change significantly, but CK and TNF-α increased significantly in the supplement group. Therefore, this results showed that NAC improved the muscle fatigue, VO2max, maintained TAC, controlled lactate production, but had no influence on CK and TNF-α.

  6. Viral membrane fusion

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, Stephen C., E-mail: harrison@crystal.harvard.edu

    2015-05-15

    Membrane fusion is an essential step when enveloped viruses enter cells. Lipid bilayer fusion requires catalysis to overcome a high kinetic barrier; viral fusion proteins are the agents that fulfill this catalytic function. Despite a variety of molecular architectures, these proteins facilitate fusion by essentially the same generic mechanism. Stimulated by a signal associated with arrival at the cell to be infected (e.g., receptor or co-receptor binding, proton binding in an endosome), they undergo a series of conformational changes. A hydrophobic segment (a “fusion loop” or “fusion peptide”) engages the target-cell membrane and collapse of the bridging intermediate thus formed draws the two membranes (virus and cell) together. We know of three structural classes for viral fusion proteins. Structures for both pre- and postfusion conformations of illustrate the beginning and end points of a process that can be probed by single-virion measurements of fusion kinetics. - Highlights: • Viral fusion proteins overcome the high energy barrier to lipid bilayer merger. • Different molecular structures but the same catalytic mechanism. • Review describes properties of three known fusion-protein structural classes. • Single-virion fusion experiments elucidate mechanism.

  7. Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits.

    Science.gov (United States)

    Wang, Bin; Ardura, Juan A; Romero, Guillermo; Yang, Yanmei; Hall, Randy A; Friedman, Peter A

    2010-08-27

    The Na/H exchanger regulatory factors, NHERF1 and NHERF2, are adapter proteins involved in targeting and assembly of protein complexes. The parathyroid hormone receptor (PTHR) interacts with both NHERF1 and NHERF2. The NHERF proteins toggle PTHR signaling from predominantly activation of adenylyl cyclase in the absence of NHERF to principally stimulation of phospholipase C when the NHERF proteins are expressed. We hypothesized that this signaling switch occurs at the level of the G protein. We measured G protein activation by [(35)S]GTPgammaS binding and G(alpha) subtype-specific immunoprecipitation using three different cellular models of PTHR signaling. These studies revealed that PTHR interactions with NHERF1 enhance receptor-mediated stimulation of G(alpha)(q) but have no effect on stimulation of G(alpha)(i) or G(alpha)(s). In contrast, PTHR associations with NHERF2 enhance receptor-mediated stimulation of both G(alpha)(q) and G(alpha)(i) but decrease stimulation of G(alpha)(s). Consistent with these functional data, NHERF2 formed cellular complexes with both G(alpha)(q) and G(alpha)(i), whereas NHERF1 was found to interact only with G(alpha)(q). These findings demonstrate that NHERF interactions regulate PTHR signaling at the level of G proteins and that NHERF1 and NHERF2 exhibit isotype-specific effects on G protein activation.

  8. Revisions to the JDL data fusion model

    Science.gov (United States)

    Steinberg, Alan N.; Bowman, Christopher L.; White, Franklin E.

    1999-03-01

    The Data Fusion Model maintained by the Joint Directors of Laboratories (JDL) Data Fusion Group is the most widely-used method for categorizing data fusion-related functions. This paper discusses the current effort to revise the expand this model to facilitate the cost-effective development, acquisition, integration and operation of multi- sensor/multi-source systems. Data fusion involves combining information - in the broadest sense - to estimate or predict the state of some aspect of the universe. These may be represented in terms of attributive and relational states. If the job is to estimate the state of a people, it can be useful to include consideration of informational and perceptual states in addition to the physical state. Developing cost-effective multi-source information systems requires a method for specifying data fusion processing and control functions, interfaces, and associate databases. The lack of common engineering standards for data fusion systems has been a major impediment to integration and re-use of available technology: current developments do not lend themselves to objective evaluation, comparison or re-use. This paper reports on proposed revisions and expansions of the JDL Data FUsion model to remedy some of these deficiencies. This involves broadening the functional model and related taxonomy beyond the original military focus, and integrating the Data Fusion Tree Architecture model for system description, design and development.

  9. Realizing Technologies for Magnetized Target Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Wurden, Glen A. [Los Alamos National Laboratory

    2012-08-24

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  10. Economics of fusion research

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    1977-10-15

    This report provides the results of a study of methods of economic analysis applied to the evaluation of fusion research. The study recognizes that a hierarchy of economic analyses of research programs exists: standard benefit-cost analysis, expected value of R and D information, and expected utility analysis. It is shown that standard benefit-cost analysis, as commonly applied to research programs, is inadequate for the evaluation of a high technology research effort such as fusion research. A methodology for performing an expected value analysis is developed and demonstrated and an overview of an approach to perform an expected utility analysis of fusion research is presented. In addition, a potential benefit of fusion research, not previously identified, is discussed and rough estimates of its magnitude are presented. This benefit deals with the effect of a fusion research program on optimal fossil fuel consumption patterns. The results of this study indicate that it is both appropriate and possible to perform an expected value analysis of fusion research in order to assess the economics of a fusion research program. The results indicate further that the major area of benefits of fusion research is likely due to the impact of a fusion research program on optimal fossil fuel consumption patterns and it is recommended that this benefit be included in future assessments of fusion research economics.

  11. Materials research for fusion

    Science.gov (United States)

    Knaster, J.; Moeslang, A.; Muroga, T.

    2016-05-01

    Fusion materials research started in the early 1970s following the observation of the degradation of irradiated materials used in the first commercial fission reactors. The technological challenges of fusion energy are intimately linked with the availability of suitable materials capable of reliably withstanding the extremely severe operational conditions of fusion reactors. Although fission and fusion materials exhibit common features, fusion materials research is broader. The harder mono-energetic spectrum associated with the deuterium-tritium fusion neutrons (14.1 MeV compared to hydrogen and helium as transmutation products that might lead to a (at present undetermined) degradation of structural materials after a few years of operation. Overcoming the historical lack of a fusion-relevant neutron source for materials testing is an essential pending step in fusion roadmaps. Structural materials development, together with research on functional materials capable of sustaining unprecedented power densities during plasma operation in a fusion reactor, have been the subject of decades of worldwide research efforts underpinning the present maturity of the fusion materials research programme.

  12. 基于多传感器信息融合的汽车酒驾测控系统设计%The design on vehicle alcohol detection and control system based on multi-sensor data fusion

    Institute of Scientific and Technical Information of China (English)

    刘艳红; 柏逢明

    2015-01-01

    To overcome the impact of detection precision and accuracy of interior vehicle flow in traditional vehicle alcohol detection and control system with a single sensor, a vehicle alcohol detection and control system via multi-sensor fusion technologies is proposed. Based on D-S evidence theory, an information fusion structure is given. The mainly hardware modules of the system are also designed. The designing scheme of vehicle alcohol detection and control system via multi-sensor data fusion approach is finished.%针对传统单点汽车酒驾检测系统忽略了车内气流流动对检测精度和准确度的影响,文章探索性地提出了一种基于多传感器融合技术的汽车室内酒驾测控方法。基于D-S证据理论设计信息融合算法,并设计了酒驾测控系统的主要硬件系统与工作模式,完成了基于多传感器检测的汽车酒驾检测与控制系统方案设计。

  13. Aspergillus nidulans alpha-galactosidase of glycoside hydrolase family 36 catalyses the formation of alpha-galacto-oligosaccharides by transglycosylation.

    Science.gov (United States)

    Nakai, Hiroyuki; Baumann, Martin J; Petersen, Bent O; Westphal, Yvonne; Hachem, Maher Abou; Dilokpimol, Adiphol; Duus, Jens Ø; Schols, Henk A; Svensson, Birte

    2010-09-01

    The alpha-galactosidase from Aspergillus nidulans (AglC) belongs to a phylogenetic cluster containing eukaryotic alpha-galactosidases and alpha-galacto-oligosaccharide synthases of glycoside hydrolase family 36 (GH36). The recombinant AglC, produced in high yield (0.65 g.L(-1) culture) as His-tag fusion in Escherichia coli, catalysed efficient transglycosylation with alpha-(1-->6) regioselectivity from 40 mm 4-nitrophenol alpha-d-galactopyranoside, melibiose or raffinose, resulting in a 37-74% yield of 4-nitrophenol alpha-D-Galp-(1-->6)-D-Galp, alpha-D-Galp-(1-->6)-alpha-D-Galp-(1-->6)-D-Glcp and alpha-D-Galp-(1-->6)-alpha-D-Galp-(1-->6)-D-Glcp-(alpha1-->beta2)-d-Fruf (stachyose), respectively. Furthermore, among 10 monosaccharide acceptor candidates (400 mm) and the donor 4-nitrophenol alpha-D-galactopyranoside (40 mm), alpha-(1-->6) linked galactodisaccharides were also obtained with galactose, glucose and mannose in high yields of 39-58%. AglC did not transglycosylate monosaccharides without the 6-hydroxymethyl group, i.e. xylose, L-arabinose, L-fucose and L-rhamnose, or with axial 3-OH, i.e. gulose, allose, altrose and L-rhamnose. Structural modelling using Thermotoga maritima GH36 alpha-galactosidase as the template and superimposition of melibiose from the complex with human GH27 alpha-galactosidase supported that recognition at subsite +1 in AglC presumably requires a hydrogen bond between 3-OH and Trp358 and a hydrophobic environment around the C-6 hydroxymethyl group. In addition, successful transglycosylation of eight of 10 disaccharides (400 mm), except xylobiose and arabinobiose, indicated broad specificity for interaction with the +2 subsite. AglC thus transferred alpha-galactosyl to 6-OH of the terminal residue in the alpha-linked melibiose, maltose, trehalose, sucrose and turanose in 6-46% yield and the beta-linked lactose, lactulose and cellobiose in 28-38% yield. The product structures were identified using NMR and ESI-MS and five of the 13

  14. Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts

    DEFF Research Database (Denmark)

    Su, J; Muranjan, M; Sap, J

    1999-01-01

    BACKGROUND: Fyn and c-Src are two of the most widely expressed Src-family kinases. Both are strongly implicated in the control of cytoskeletal organization and in the generation of integrin-dependent signalling responses in fibroblasts. These proteins are representative of a large family of tyros...

  15. Alpha Channeling in Mirror Machines

    Energy Technology Data Exchange (ETDEWEB)

    Fisch N.J.

    2005-10-19

    Because of their engineering simplicity, high-β, and steady-state operation, mirror machines and related open-trap machines such as gas dynamic traps, are an attractive concept for achieving controlled nuclear fusion. In these open-trap machines, the confinement occurs by means of magnetic mirroring, without the magnetic field lines closing upon themselves within the region of particle confinement. Unfortunately, these concepts have not achieved to date very spectacular laboratory results, and their reactor prospects are dimmed by the prospect of a low Q-factor, the ratio of fusion power produced to auxiliary power. Nonetheless, because of its engineering promise, over the years numerous improvements have been proposed to enhance the reactor prospects of mirror fusion, such as tandem designs, end-plugging, and electric potential barriers.

  16. INTRODUCTION: Status report on fusion research

    Science.gov (United States)

    Burkart, Werner

    2005-10-01

    A major milestone on the path to fusion energy was reached in June 2005 on the occasion of the signing of the joint declaration of all parties to the ITER negotiations, agreeing on future arrangements and on the construction site at Cadarache in France. The International Atomic Energy Agency has been promoting fusion activities since the late 1950s; it took over the auspices of the ITER Conceptual Design Activities in 1988, and of the ITER Engineering and Design Activities in 1992. The Agency continues its support to Member States through the organization of consultancies, workshops and technical meetings, the most prominent being the series of International Fusion Energy Conferences (formerly called the International Conference on Plasma Physics and Controlled Nuclear Fusion Research). The meetings serve as a platform for experts from all Member States to have open discussions on their latest accomplishments as well as on their problems and eventual solutions. The papers presented at the meetings and conferences are routinely published, many being sent to the journal it Nuclear Fusion, co-published monthly by Institute of Physics Publishing, Bristol, UK. The journal's reputation is reflected in the fact that it is a world-renowned publication, and the International Fusion Research Council has used it for the publication of a Status Report on Controlled Thermonuclear Fusion in 1978 and 1990. This present report marks the conclusion of the preparatory phases of ITER activities. It provides background information on the progress of fusion research within the last 15 years. The International Fusion Research Council (IFRC), which initiated the report, was fully aware of the complexities of including all scientific results in just one paper, and so decided to provide an overview and extensive references for the interested reader who need not necessarily be a fusion specialist. Professor Predhiman K. Kaw, Chairman, prepared the report on behalf of the IFRC, reflecting

  17. Mechanics of post-fusion exocytotic vesicle

    Science.gov (United States)

    Stephens, Thomas; Wu, Zhanghan; Liu, Jian

    2017-06-01

    Exocytosis is an important cellular process controlled by metabolic signaling. It involves vesicle fusion to the plasma membrane, followed by the opening of a fusion pore, and the subsequent release of the vesicular lumen content into the extracellular space. While most modeling efforts focus on the events leading to membrane fusion, how the vesicular membrane remodels after fusing to plasma membrane remains unclear. This latter event dictates the nature and the efficiency of exocytotic vesicular secretions, and is thus critical for exocytotic function. We provide a generic membrane mechanical model to systematically study the fate of post-fusion vesicles. We show that while membrane stiffness favors full-collapse vesicle fusion into the plasma membrane, the intravesicular pressure swells the vesicle and causes the fusion pore to shrink. Dimensions of the vesicle and its associated fusion pore further modulate this mechanical antagonism. We systematically define the mechanical conditions that account for the full spectrum of the observed vesicular secretion modes. Our model therefore can serve as a unified theoretical framework that sheds light on the elaborate control mechanism of exocytosis.

  18. Genome Fusion Detection: a novel method to detect fusion genes from SNP-array data.

    Science.gov (United States)

    Thieme, Sebastian; Groth, Philip

    2013-03-15

    Fusion genes result from genomic rearrangements, such as deletions, amplifications and translocations. Such rearrangements can also frequently be observed in cancer and have been postulated as driving event in cancer development. to detect them, one needs to analyze the transition region of two segments with different copy number, the location where fusions are known to occur. Finding fusion genes is essential to understanding cancer development and may lead to new therapeutic approaches. Here we present a novel method, the Genomic Fusion Detection algorithm, to predict fusion genes on a genomic level based on SNP-array data. This algorithm detects genes at the transition region of segments with copy number variation. With the application of defined constraints, certain properties of the detected genes are evaluated to predict whether they may be fused. We evaluated our prediction by calculating the observed frequency of known fusions in both primary cancers and cell lines. We tested a set of cell lines positive for the BCR-ABL1 fusion and prostate cancers positive for the TMPRSS2-ERG fusion. We could detect the fusions in all positive cell lines, but not in the negative controls.

  19. Control of gene expression by the retinoic acid-related orphan receptor alpha in HepG2 human hepatoma cells.

    Directory of Open Access Journals (Sweden)

    Caroline Chauvet

    Full Text Available Retinoic acid-related Orphan Receptor alpha (RORα; NR1F1 is a widely distributed nuclear receptor involved in several (pathophysiological functions including lipid metabolism, inflammation, angiogenesis, and circadian rhythm. To better understand the role of this nuclear receptor in liver, we aimed at displaying genes controlled by RORα in liver cells by generating HepG2 human hepatoma cells stably over-expressing RORα. Genes whose expression was altered in these cells versus control cells were displayed using micro-arrays followed by qRT-PCR analysis. Expression of these genes was also altered in cells in which RORα was transiently over-expressed after adenoviral infection. A number of the genes found were involved in known pathways controlled by RORα, for instance LPA, NR1D2 and ADIPOQ in lipid metabolism, ADIPOQ and PLG in inflammation, PLG in fibrinolysis and NR1D2 and NR1D1 in circadian rhythm. This study also revealed that genes such as G6PC, involved in glucose homeostasis, and AGRP, involved in the control of body weight, are also controlled by RORα. Lastly, SPARC, involved in cell growth and adhesion, and associated with liver carcinogenesis, was up-regulated by RORα. SPARC was found to be a new putative RORα target gene since it possesses, in its promoter, a functional RORE as evidenced by EMSAs and transfection experiments. Most of the other genes that we found regulated by RORα also contained putative ROREs in their regulatory regions. Chromatin immunoprecipitation (ChIP confirmed that the ROREs present in the SPARC, PLG, G6PC, NR1D2 and AGRP genes were occupied by RORα in HepG2 cells. Therefore these genes must now be considered as direct RORα targets. Our results open new routes on the roles of RORα in glucose metabolism and carcinogenesis within cells of hepatic origin.

  20. Fusion research: the past is prologue

    Energy Technology Data Exchange (ETDEWEB)

    Post, R F

    1998-10-14

    At this juncture fusion research can be viewed as being at a turning point, a time to review its past and to imagine its future. Today, almost 50 years since the first serious attempts to address the daunting problem of achieving controlled fusion, we have both an opportunity and a challenge. Some predictions place fusion research today at a point midway between its first inception and its eventual maturation - in the middle of the 21st century - when fusion would become a major source of energy. Our opportunity therefore is to assess what we have learned from 50 years of hard work and use that knowledge as a starting point for new and better approaches to solving the fusion problem. Our challenge is to prove the "50 more years" prophesy wrong, by finding ways to shorten the time when fusion power becomes a reality. The thesis will be advanced that in the magnetic confinement approach to fusion open-ended magnetic confinement geometries offer much in responding to the challenge. A major advantage of open systems is that, owing to their theoretically and experimentally demonstrated ability to suppress plasma instabilities of both the MHD and the high-frequency wave-particle variety, the confinement becomes predictable from "classical," i.e., Fokker-Planck-type analysis. In a time of straitened budgetary circumstances for magnetic fusion research now being faced in the United States, the theoretical tractability of mirror-based systems is a substantial asset. In pursuing this avenue it is also necessary to keep an open mind as to the forms that mirror-based fusion power plants might take. For example, one can look to the high-energy physics community for a possible model: This community has shown the feasibility of constructing large and complex particle accelerators using superconducting magnets, vacuum chambers and complicated particle-handling technology, housed in underground tunnels that are 20 or more kilometers long. In the paper examples of mirror

  1. Muon Catalyzed Fusion

    Science.gov (United States)

    Armour, Edward A.G.

    2007-01-01

    Muon catalyzed fusion is a process in which a negatively charged muon combines with two nuclei of isotopes of hydrogen, e.g, a proton and a deuteron or a deuteron and a triton, to form a muonic molecular ion in which the binding is so tight that nuclear fusion occurs. The muon is normally released after fusion has taken place and so can catalyze further fusions. As the muon has a mean lifetime of 2.2 microseconds, this is the maximum period over which a muon can participate in this process. This article gives an outline of the history of muon catalyzed fusion from 1947, when it was first realised that such a process might occur, to the present day. It includes a description of the contribution that Drachrnan has made to the theory of muon catalyzed fusion and the influence this has had on the author's research.

  2. Tritium management in fusion reactors

    Energy Technology Data Exchange (ETDEWEB)

    Galloway, T.R.

    1978-05-01

    This is a review paper covering the key environmental and safety issues and how they have been handled in the various magnetic and inertial confinement concepts and reference designs. The issues treated include: tritium accident analyses, tritium process control, occupational safety, HTO formation rate from the gas-phase, disposal of tritium contaminated wastes, and environmental impact--each covering the Joint European Tokamak (J.E.T. experiment), Tokamak Fusion Test Reactor (TFTR), Russian T-20, The Next Step (TNS) designs by Westinghouse/ORNL and General Atomic/ANL, the ANL and ORNL EPR's, the G.A. Doublet Demonstration Reactor, the Italian Fintor-D and the ORNL Demo Studies. There are also the following full scale plant reference designs: UWMAK-III, LASL's Theta Pinch Reactor Design (RTPR), Mirror Fusion Reactor (MFR), Tandem Mirror Reactor (TMR), and the Mirror Hybrid Reactor (MHR). There are four laser device breakeven experiments, SHIVA-NOVA, LLL reference designs, ORNL Laser Fusion power plant, the German ''Saturn,'' and LLL's Laser Fusion EPR I and II.

  3. Design of Fusion Safety Data Base

    Science.gov (United States)

    Aoki, Isao; Seki, Yasushi

    1994-03-01

    This report presents a data base architecture with its circumstance which is designed to be used for safety design and analysis studies. Design of Fusion Safety Data Base has been carried out to take into account a great number of published references on operation and control of fusion energy and engineering features to secure safety of fusion devices. Data Base of Fiscal Year 1993 - which has been established over an extended year - realized on PC (Personal Computer) peripherals is reported. The concept of data base architecture with its attributive issues and a manipulating way for users are also shown.

  4. LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13).

    Science.gov (United States)

    Panagopoulos, Ioannis; Gorunova, Ludmila; Bjerkehagen, Bodil; Lobmaier, Ingvild; Heim, Sverre

    2015-11-01

    RNA sequencing of an aneurysmal benign fibrous histiocytoma with the karyotype 46,XY,t(3;11)(p21;q13),del(6)(p23)[17]/46,XY[2] showed that the t(3;11) generated two fusion genes: LAMTOR1-PRKCD and NUMA1-SFMBT1. RT-PCR together with Sanger sequencing verified the presence of fusion transcripts from both fusion genes. In the LAMTOR1-PRKCD fusion, the part of the PRKCD gene coding for the catalytic domain of the serine/threonine kinase is under control of the LAMTOR1 promoter. In the NUMA1-SFMBT1 fusion, the part of the SFMBT1 gene coding for two of four malignant brain tumor domains and the sterile alpha motif domain is controlled by the NUMA1 promoter. The data support a neoplastic genesis of aneurysmal benign fibrous histiocytoma and indicate a pathogenetic role for LAMTOR1-PRKCD and NUMA1-SFMBT1. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Fusion research principles

    CERN Document Server

    Dolan, Thomas James

    2013-01-01

    Fusion Research, Volume I: Principles provides a general description of the methods and problems of fusion research. The book contains three main parts: Principles, Experiments, and Technology. The Principles part describes the conditions necessary for a fusion reaction, as well as the fundamentals of plasma confinement, heating, and diagnostics. The Experiments part details about forty plasma confinement schemes and experiments. The last part explores various engineering problems associated with reactor design, vacuum and magnet systems, materials, plasma purity, fueling, blankets, neutronics

  6. The perspectives of fusion energy: The roadmap towards energy production and fusion energy in a distributed energy system

    DEFF Research Database (Denmark)

    Naulin, Volker; Juul Rasmussen, Jens; Korsholm, Søren Bang

    2014-01-01

    Controlled thermonuclear fusion has the potential of providing an environmentally friendly and inexhaustible energy source for mankind. Fusion energy, which powers our sun and the stars, is released when light elements, such as the hydrogen isotopes deuterium and tritium, fuse together. This occurs...... The presentation will discuss the present status of the fusion energy research and review the EU Roadmap towards a fusion power plant. Further the cost of fusion energy is assessed as well as how it can be integrated in the distributed energy system...

  7. Magnetic fusion reactor economics

    Energy Technology Data Exchange (ETDEWEB)

    Krakowski, R.A.

    1995-12-01

    An almost primordial trend in the conversion and use of energy is an increased complexity and cost of conversion systems designed to utilize cheaper and more-abundant fuels; this trend is exemplified by the progression fossil fission {yields} fusion. The present projections of the latter indicate that capital costs of the fusion ``burner`` far exceed any commensurate savings associated with the cheapest and most-abundant of fuels. These projections suggest competitive fusion power only if internal costs associate with the use of fossil or fission fuels emerge to make them either uneconomic, unacceptable, or both with respect to expensive fusion systems. This ``implementation-by-default`` plan for fusion is re-examined by identifying in general terms fusion power-plant embodiments that might compete favorably under conditions where internal costs (both economic and environmental) of fossil and/or fission are not as great as is needed to justify the contemporary vision for fusion power. Competitive fusion power in this context will require a significant broadening of an overly focused program to explore the physics and simbiotic technologies leading to more compact, simplified, and efficient plasma-confinement configurations that reside at the heart of an attractive fusion power plant.

  8. Frontiers in fusion research

    CERN Document Server

    Kikuchi, Mitsuru

    2011-01-01

    Frontiers in Fusion Research provides a systematic overview of the latest physical principles of fusion and plasma confinement. It is primarily devoted to the principle of magnetic plasma confinement, that has been systematized through 50 years of fusion research. Frontiers in Fusion Research begins with an introduction to the study of plasma, discussing the astronomical birth of hydrogen energy and the beginnings of human attempts to harness the Sun's energy for use on Earth. It moves on to chapters that cover a variety of topics such as: * charged particle motion, * plasma kinetic theory, *

  9. Magnetic-confinement fusion

    Science.gov (United States)

    Ongena, J.; Koch, R.; Wolf, R.; Zohm, H.

    2016-05-01

    Our modern society requires environmentally friendly solutions for energy production. Energy can be released not only from the fission of heavy nuclei but also from the fusion of light nuclei. Nuclear fusion is an important option for a clean and safe solution for our long-term energy needs. The extremely high temperatures required for the fusion reaction are routinely realized in several magnetic-fusion machines. Since the early 1990s, up to 16 MW of fusion power has been released in pulses of a few seconds, corresponding to a power multiplication close to break-even. Our understanding of the very complex behaviour of a magnetized plasma at temperatures between 150 and 200 million °C surrounded by cold walls has also advanced substantially. This steady progress has resulted in the construction of ITER, a fusion device with a planned fusion power output of 500 MW in pulses of 400 s. ITER should provide answers to remaining important questions on the integration of physics and technology, through a full-size demonstration of a tenfold power multiplication, and on nuclear safety aspects. Here we review the basic physics underlying magnetic fusion: past achievements, present efforts and the prospects for future production of electrical energy. We also discuss questions related to the safety, waste management and decommissioning of a future fusion power plant.

  10. Fusion of Nonionic Vesicles

    DEFF Research Database (Denmark)

    Bulut, Sanja; Oskolkova, M. Z.; Schweins, R.

    2010-01-01

    We present an experimental study of vesicle fusion using light and neutron scattering to monitor fusion events. Vesicles are reproducibly formed with an extrusion procedure using an single amphiphile triethylene glycol mono-n-decyl ether in water. They show long-term stability for temperatures...... around 20 C, but at temperatures above 26 C we observe an increase in the scattered intensity due to fusion. The system is unusually well suited for the study of basic mechanisms of vesicle fusion. The vesicles are flexible with a bending rigidity of only a few k(H)T. The monolayer spontaneous curvature...

  11. IL-4 receptor-alpha-dependent control of Cryptococcus neoformans in the early phase of pulmonary infection.

    Directory of Open Access Journals (Sweden)

    Andreas Grahnert

    Full Text Available Cryptococcus neoformans is an opportunistic fungal pathogen that causes lung inflammation and meningoencephalitis in immunocompromised people. Previously we showed that mice succumb to intranasal infection by induction of pulmonary interleukin (IL-4Rα-dependent type 2 immune responses, whereas IL-12-dependent type 1 responses confer resistance. In the experiments presented here, IL-4Rα⁻/⁻ mice unexpectedly show decreased fungal control early upon infection with C. neoformans, whereas wild-type mice are able to control fungal growth accompanied by enhanced macrophage and dendritic cell recruitment to the site of infection. Lower pulmonary recruitment of macrophages and dendritic cells in IL-4Rα⁻/⁻ mice is associated with reduced pulmonary expression of CCL2 and CCL20 chemokines. Moreover, IFN-γ and nitric oxide production are diminished in IL-4Rα⁻/⁻ mice compared to wild-type mice. To directly study the potential mechanism(s responsible for reduced production of IFN-γ, conventional dendritic cells were stimulated with C. neoformans in the presence of IL-4 which results in increased IL-12 production and reduced IL-10 production. Together, a beneficial role of early IL-4Rα signaling is demonstrated in pulmonary cryptococcosis, which contrasts with the well-known IL-4Rα-mediated detrimental effects in the late phase.

  12. Soldier systems sensor fusion

    Science.gov (United States)

    Brubaker, Kathryne M.

    1998-08-01

    This paper addresses sensor fusion and its applications in emerging Soldier Systems integration and the unique challenges associated with the human platform. Technology that,provides the highest operational payoff in a lightweight warrior system must not only have enhanced capabilities, but have low power components resulting in order of magnitude reductions coupled with significant cost reductions. These reductions in power and cost will be achieved through partnership with industry and leveraging of commercial state of the art advancements in microelectronics and power sources. As new generation of full solution fire control systems (to include temperature, wind and range sensors) and target acquisition systems will accompany a new generation of individual combat weapons and upgrade existing weapon systems. Advanced lightweight thermal, IR, laser and video senors will be used for surveillance, target acquisition, imaging and combat identification applications. Multifunctional sensors will provide embedded training features in combat configurations allowing the soldier to 'train as he fights' without the traditional cost and weight penalties associated with separate systems. Personal status monitors (detecting pulse, respiration rate, muscle fatigue, core temperature, etc.) will provide commanders and highest echelons instantaneous medical data. Seamless integration of GPS and dead reckoning (compass and pedometer) and/or inertial sensors will aid navigation and increase position accuracy. Improved sensors and processing capability will provide earlier detection of battlefield hazards such as mines, enemy lasers and NBC (nuclear, biological, chemical) agents. Via the digitized network the situational awareness database will automatically be updated with weapon, medical, position and battlefield hazard data. Soldier Systems Sensor Fusion will ultimately establish each individual soldier as an individual sensor on the battlefield.

  13. Tumor necrosis factor-alpha G-238A polymorphism and coronary artery disease risk: a meta-analysis of 4,222 patients and 4,832 controls

    Directory of Open Access Journals (Sweden)

    Hua XP

    2015-09-01

    Full Text Available Xian-Ping Hua,1,* Xiao-Dong Zhang,2,* Joey SW Kwong,3,* Xian-Tao Zeng,4 Zhen-Jian Zhang,1 Wan-Lin Wei21Department of Cardiology, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei Province, 2Department of Cardiology and 4th Cadres Ward, General Hospital of Beijing Military Command, Beijing, 3Chinese Evidence-Based Medicine Center and Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, 4Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan, People’s Republic of China*These authors contributed equally to this workBackground: The aim of the present study was to investigate the association between tumor necrosis factor-alpha (TNF-α gene G-238A polymorphism and risk of coronary artery disease (CAD using a meta-analytical approach.Methods: The PubMed and Embase databases were searched for relevant publications up to January 13, 2015. Four authors (XPH, XDZ, XTZ, and ZJZ independently selected the studies, extracted, and analyzed the data using the Comprehensive Meta-Analysis software. The sensitivity and subgroups analyses were also performed. Either a fixed effects or a random effects model was used to estimate pooled odds ratios (ORs and their 95% confidence intervals (CIs.Results: Finally, ten articles including eleven case-control studies involving 4,222 patients and 4,832 controls were yielded. The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89–1.30; AA vs GG: OR =1.15, 95% CI =0.59–2.25; GA vs GG: OR =1.14, 95% CI =0.88–1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56–2.14; (GA + AA vs GG: OR =1.11, 95% CI =0.90–1.38. In the subgroup analyses, similar results were obtained with overall populations. The sensitivity analyses showed that the overall results were robust. No publication bias was detected.Conclusion: Based on current evidence, we can conclude that TNF-α G-238A polymorphism

  14. The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug target.

    Directory of Open Access Journals (Sweden)

    Iris Alchanati

    Full Text Available BACKGROUND: The topoisomerases Top1, Top2alpha and Top2beta are important molecular targets for antitumor drugs, which specifically poison Top1 or Top2 isomers. While it was previously demonstrated that poisoned Top1 and Top2beta are subject to proteasomal degradation, this phenomena was not demonstrated for Top2alpha. METHODOLOGY/PRINCIPAL FINDINGS: We show here that Top2alpha is subject to drug induced proteasomal degradation as well, although at a lower rate than Top2beta. Using an siRNA screen we identified Bmi1 and Ring1A as subunits of an E3 ubiquitin ligase involved in this process. We show that silencing of Bmi1 inhibits drug-induced Top2alpha degradation, increases the persistence of Top2alpha-DNA cleavage complex, and increases Top2 drug efficacy. The Bmi1/Ring1A ligase ubiquitinates Top2alpha in-vitro and cellular overexpression of Bmi1 increases drug induced Top2alpha ubiquitination. A small-molecular weight compound, identified in a screen for inhibitors of Bmi1/Ring1A ubiquitination activity, also prevents Top2alpha ubiquitination and drug-induced Top2alpha degradation. This ubiquitination inhibitor increases the efficacy of topoisomerase 2 poisons in a synergistic manner. CONCLUSIONS/SIGNIFICANCE: The discovery that poisoned Top2alpha is undergoing proteasomal degradation combined with the involvement of Bmi1/Ring1A, allowed us to identify a small molecule that inhibits the degradation process. The Bmi1/Ring1A inhibitor sensitizes cells to Top2 drugs, suggesting that this type of drug combination will have a beneficial therapeutic outcome. As Bmi1 is also a known oncogene, elevated in numerous types of cancer, the identified Bmi1/Ring1A ubiquitin ligase inhibitors can also be potentially used to directly target the oncogenic properties of Bmi1.

  15. Cell fusion and nuclear fusion in plants.

    Science.gov (United States)

    Maruyama, Daisuke; Ohtsu, Mina; Higashiyama, Tetsuya

    2016-12-01

    Eukaryotic cells are surrounded by a plasma membrane and have a large nucleus containing the genomic DNA, which is enclosed by a nuclear envelope consisting of the outer and inner nuclear membranes. Although these membranes maintain the identity of cells, they sometimes fuse to each other, such as to produce a zygote during sexual reproduction or to give rise to other characteristically polyploid tissues. Recent studies have demonstrated that the mechanisms of plasma membrane or nuclear membrane fusion in plants are shared to some extent with those of yeasts and animals, despite the unique features of plant cells including thick cell walls and intercellular connections. Here, we summarize the key factors in the fusion of these membranes during plant reproduction, and also focus on "non-gametic cell fusion," which was thought to be rare in plant tissue, in which each cell is separated by a cell wall.

  16. Nuclear fusion inside condense matters

    Institute of Scientific and Technical Information of China (English)

    HE Jing-tang

    2007-01-01

    This article describes in detail the nuclear fusion inside condense matters--the Fleischmann-Pons effect, the reproducibility of cold fusions, self-consistentcy of cold fusions and the possible applications.

  17. Ab initio alpha-alpha scattering

    CERN Document Server

    Elhatisari, Serdar; Rupak, Gautam; Epelbaum, Evgeny; Krebs, Hermann; Lähde, Timo A; Luu, Thomas; Meißner, Ulf-G

    2015-01-01

    Processes involving alpha particles and alpha-like nuclei comprise a major part of stellar nucleosynthesis and hypothesized mechanisms for thermonuclear supernovae. In an effort towards understanding alpha processes from first principles, we describe in this letter the first ab initio calculation of alpha-alpha scattering. We use lattice effective field theory to describe the low-energy interactions of nucleons and apply a technique called the adiabatic projection method to reduce the eight-body system to an effective two-cluster system. We find good agreement between lattice results and experimental phase shifts for S-wave and D-wave scattering. The computational scaling with particle number suggests that alpha processes involving heavier nuclei are also within reach in the near future.

  18. Role of Electromagnetic Field Exposure in Childhood Acute Lymphoblastic Leukemia and No Impact of Urinary Alpha- Amylase--a Case Control Study in Tehran, Iran.

    Science.gov (United States)

    Tabrizi, Maral Mazloomi; Hosseini, Seyed Ahmad

    2015-01-01

    Childhood acute lymphoblastic leukemia (ALL) is one of the most common hematologic malignancies which accounts for one fourth of all childhood cancer cases. Exposure to environmental factors around the time of conception or pregnancy can increase the risk of ALL in the offspring. This study aimed to evaluate the influence of prenatal and postnatal exposure to high voltage power lines on the incidence of childhood ALL. It also examines the role of various factors such as environmental factors and alpha-amylase as a marker in the development of leukemia. This cross-sectional case control study was carried out on 22 cases and 100 controls who born and lived in low socioeconomic families in Tehran and were hospitalized for therapeutic purposes in different hospitals of rom 2013-2014. With regard to the underlying risk factors; familial history and parental factors were detected as risk factors of ALL but in this age, socioeconomic and zonal matched case control study, prenatal and childhood exposure to high voltage power lines was considered as the most important environmental risk factor (p=0.006, OR=3.651, CI 95% 1.692-7.878). As the population study was from low socioeconomic state, use of mobiles, computers and microwaves was negligible. Moreover prenatal and postnatal exposure to all indoor electrically charged objects were not detected as significant environmental factors in the present study. This work defined the risk of environmental especially continuous pre and postnatal exposure to high voltage power lines and living in pollutant regions through the parents or children as well as the previously described risk factors of ALL for the first time in low socioeconomic status Iranian population.

  19. Fusion of biological membranes

    Indian Academy of Sciences (India)

    K Katsov; M Müller; M Schick

    2005-06-01

    The process of membrane fusion has been examined by Monte Carlo simulation, and is found to be very different than the conventional picture. The differences in mechanism lead to several predictions, in particular that fusion is accompanied by transient leakage. This prediction has recently been verified. Self-consistent field theory is applied to examine the free energy barriers in the different scenarios.

  20. Sensor Data Fusion

    DEFF Research Database (Denmark)

    Plascencia, Alfredo; Stepán, Petr

    2006-01-01

    The main contribution of this paper is to present a sensor fusion approach to scene environment mapping as part of a Sensor Data Fusion (SDF) architecture. This approach involves combined sonar array with stereo vision readings.  Sonar readings are interpreted using probability density functions...

  1. Complementary Advanced Fusion Exploration

    Science.gov (United States)

    2005-08-01

    homographic computer vision image fusion, out-of-sequence measurement and track data handling, Nash bargaining approaches to sensor management... homographic fusion notions are identified together with the Nash approach, the pursuit-evasion approach to threat situation outcome determination, and the

  2. Cell fusions in mammals

    DEFF Research Database (Denmark)

    Larsson, Lars-Inge; Bjerregaard, Bolette; Talts, Jan Fredrik

    2008-01-01

    Cell fusions are important to fertilization, placentation, development of skeletal muscle and bone, calcium homeostasis and the immune defense system. Additionally, cell fusions participate in tissue repair and may be important to cancer development and progression. A large number of factors appe...

  3. Compact fusion reactors

    CERN Document Server

    CERN. Geneva

    2015-01-01

    Fusion research is currently to a large extent focused on tokamak (ITER) and inertial confinement (NIF) research. In addition to these large international or national efforts there are private companies performing fusion research using much smaller devices than ITER or NIF. The attempt to achieve fusion energy production through relatively small and compact devices compared to tokamaks decreases the costs and building time of the reactors and this has allowed some private companies to enter the field, like EMC2, General Fusion, Helion Energy, Lawrenceville Plasma Physics and Lockheed Martin. Some of these companies are trying to demonstrate net energy production within the next few years. If they are successful their next step is to attempt to commercialize their technology. In this presentation an overview of compact fusion reactor concepts is given.

  4. Intermediate-affinity LFA-1 binds alpha-actinin-1 to control migration at the leading edge of the T cell.

    Science.gov (United States)

    Stanley, Paula; Smith, Andrew; McDowall, Alison; Nicol, Alastair; Zicha, Daniel; Hogg, Nancy

    2008-01-01

    T lymphocytes use LFA-1 to migrate into lymph nodes and inflammatory sites. To investigate the mechanisms regulating this migration, we utilize mAbs selective for conformational epitopes as probes for active LFA-1. Expression of the KIM127 epitope, but not the 24 epitope, defines the extended conformation of LFA-1, which has intermediate affinity for ligand ICAM-1. A key finding is that KIM127-positive LFA-1 forms new adhesions at the T lymphocyte leading edge. This LFA-1 links to the cytoskeleton through alpha-actinin-1 and disruption at the level of integrin or actin results in loss of cell spreading and migratory speed due to a failure of attachment at the leading edge. The KIM127 pattern contrasts with high-affinity LFA-1 that expresses both 24 and KIM127 epitopes, is restricted to the mid-cell focal zone and controls ICAM-1 attachment. Identification of distinctive roles for intermediate- and high-affinity LFA-1 in T lymphocyte migration provides a biological function for two active conformations of this integrin for the first time.

  5. Visualize Your Data with Google Fusion Tables

    Science.gov (United States)

    Brisbin, K. E.

    2011-12-01

    Google Fusion Tables is a modern data management platform that makes it easy to host, manage, collaborate on, visualize, and publish tabular data online. Fusion Tables allows users to upload their own data to the Google cloud, which they can then use to create compelling and interactive visualizations with the data. Users can view data on a Google Map, plot data in a line chart, or display data along a timeline. Users can share these visualizations with others to explore and discover interesting trends about various types of data, including scientific data such as invasive species or global trends in disease. Fusion Tables has been used by many organizations to visualize a variety of scientific data. One example is the California Redistricting Map created by the LA Times: http://goo.gl/gwZt5 The Pacific Institute and Circle of Blue have used Fusion Tables to map the quality of water around the world: http://goo.gl/T4SX8 The World Resources Institute mapped the threat level of coral reefs using Fusion Tables: http://goo.gl/cdqe8 What attendees will learn in this session: This session will cover all the steps necessary to use Fusion Tables to create a variety of interactive visualizations. Attendees will begin by learning about the various options for uploading data into Fusion Tables, including Shapefile, KML file, and CSV file import. Attendees will then learn how to use Fusion Tables to manage their data by merging it with other data and controlling the permissions of the data. Finally, the session will cover how to create a customized visualization from the data, and share that visualization with others using both Fusion Tables and the Google Maps API.

  6. A20 overexpression under control of mouse osteocalcin promoter in MC3T3-E1 cells inhibited tumor necrosis factor-alpha-induced apoptosis

    Institute of Scientific and Technical Information of China (English)

    Yue-juan QIN; Zhen-lin ZHANG; Lu-yang YU; Jin-wei HE; Ya-nan HOU; Tian-jin LIU; Jia-cai WU; Song-hua WU; Li-he GUO

    2006-01-01

    Aim: To construct an A20 expression vector under the control of mouse osteocalcin promoter (OC-A20), and investigate osteoblastic MC3T3-E1 cell line, which stably overexpresses A20 protein prevented tumor necrosis factor (TNF)-alpha-induced apoptosis. Methods: OC-A20 vector was constructed by fusing a fragment of the mouse osteocalcin gene-2 promoter with human A20 complementary DNA. Then the mouse MC3T3-E1 cell line, stably transfected by A20, was established. The expression of A20 mRNA and A20 protein in the cells were detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis, respectively. To determine the specificity of A20 expression in osteoblast, the mouse osteoblastic MC3T3-E1 cell line and mouse embryo fibro-blast NIH3T3 cell line were transiently transfected with OC-A20. The anti-apoptotic role of A20 in MC3T3-E1 cells was determined by Flow cytometric analysis (FACS), terminal dUTP nick endo-labeling (TUNEL) and DNA gel electrophoresis analysis (DNA Ladder), respectively. Results: Weak A20 expression was found in MC3T3-El cells with the primers of mouse A20. A20 mRNA and A20 protein expression were identified in MC3T3-E1 cells transfected with OC-A20 using RT-PCR and Western blot analysis. Only A20 mRNA expression was found in MC3T3-E1 cell after MC3T3-E1 cells and NIH3T3 cells were transient transfected with OC-A20. A decrease obviously occurred in the rate of apoptosis in the OC-A20 group compared with the empty vector (pcDNA3) group by FACS (P<0.001). A significant increase in TUNEL positive staining was found in the pcDNA group compared with OC-A20 group (P<0.001). Simultaneously, similar effects were demonstrated in DNA gel electrophoresis analysis. Conclusion: We constructed an osteoblast-specific expression vector that expressed A20 protein in MC3T3-E1 cells and confirmed that A20 protects osteoblast against TNF-alpha-induced apoptosis.

  7. 一种不确定性复杂大时滞过程的融合控制策略%A Sort of fusion control strategy for uncertainty complex process with large time lag

    Institute of Scientific and Technical Information of China (English)

    毕波

    2014-01-01

    Aiming at the puzzle of being lower in control precision of complicated large lag process resulted by uncertainty,the paper presented a sort of control strategy based on algorithm fusion. In the paper,it studied the control puzzle and cybernetics characteristic,based on the complex process characteristic with large lag,fused that the integral control is propitious to eliminate the steady error,Smith estimator control is helpful for time lag compensation,and fuzzy control is conducive to deal with some uncertainty controls.Based on the integration of their respective ad-vantages,it gave a sort of I-Fuzzy-Smith control algorithm.Based on MATLAB simulation,it took the inertial process with large time lag as an example,and conducted the comparative study re-spectively by PID,Fuzzy-Smith and I-Fuzzy-Smith control,and the response demonstrated that the fusion control strategy would be more advantages in respect of system dynamic &static per-formance and robustness than others.The research result shows that the proposed fusion control strategy is high in control precision,and shows very strong robustness.%针对不确定性导致的复杂大时滞过程控制精度低的问题,提出了一种基于算法融合的控制策略。研究了控制难点与控制论特性,基于大时滞复杂过程特性,融合了积分控制有利于消除稳态误差,Smith预估控制有利于时滞的补偿,模糊控制有利于处理某些不确定性控制,集成各自的优势,给出了一种I-Fuzzy-Smith控制算法。基于Matlab仿真,以大时滞惯性过程为例,分别采用PID、Fuzzy-Smith和I-Fuzzy-Smith控制进行了比较研究,响应验证了融合控制策略在系统动、静态性能和鲁棒性方面的优势。研究结果表明:提出的融合控制策略控制精度高,并表现出很强的鲁棒性。

  8. Cell fusion in tumor progression: the isolation of cell fusion products by physical methods

    Directory of Open Access Journals (Sweden)

    Vincitorio Massimo

    2011-09-01

    Full Text Available Abstract Background Cell fusion induced by polyethylene glycol (PEG is an efficient but poorly controlled procedure for obtaining somatic cell hybrids used in gene mapping, monoclonal antibody production, and tumour immunotherapy. Genetic selection techniques and fluorescent cell sorting are usually employed to isolate cell fusion products, but both procedures have several drawbacks. Results Here we describe a simple improvement in PEG-mediated cell fusion that was obtained by modifying the standard single-step procedure. We found that the use of two PEG undertreatments obtains a better yield of cell fusion products than the standard method, and most of these products are bi- or trinucleated polykaryocytes. Fusion rate was quantified using fluorescent cell staining microscopy. We used this improved cell fusion and cell isolation method to compare giant cells obtained in vitro and giant cells obtained in vivo from patients with Hodgkin's disease and erythroleukemia. Conclusions In the present study we show how to improve PEG-mediated cell fusion and that cell separation by velocity sedimentation offers a simple alternative for the efficient purification of cell fusion products and to investigate giant cell formation in tumor development.

  9. The allelic distribution of -308 Tumor Necrosis Factor-alpha gene polymorphism in South African women with cervical cancer and control women

    Directory of Open Access Journals (Sweden)

    Williamson Anna-Lise

    2006-01-01

    Full Text Available Abstract Background Cervical cancer is due to infection with specific high-risk types of human papillomavirus (HPV. Although the incidence of genital HPV infection in various population groups is high, most of these regress without intervention. Investigating genetic host factors and cellular immune responses, particularly cytokines, could help to understand the association between genital HPV infection and carcinogenesis. The tumor necrosis factor alpha (TNF-α cytokine plays an important role in all stages of cervical cancer and has the ability to induce the regression of human tumors. Therefore the aim of the study was to investigate the allelic distribution of -308 TNF-α gene polymorphism in South African women with cervical cancer compared to control women. Methods Included in our study were women with histologically proven cancer of the cervix (n = 244 and hospital-based controls (n = 228. All patients and controls were from mixed race and black population groups in South Africa. The detection of a bi-allelic -308 (A/G polymorphism in the promoter region of TNF-α was investigated using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR technique. The distributions of the allelic frequencies were stratified in both patients and controls into two South African ethnic population groups. Results In this study we observed no association between the distribution of -308 TNF-α polymorphism and the risk of developing cervical cancer even after combining the data from the two ethnic populations (X2 = 2.26. In addition, using the chi-squared test we found no significant association between the known risk factors for cervical cancer and the allele distribution of -308 TNF-α. However, the frequency of the rare high-producing allele -308A of TNF-α was significantly lower in the South African population when compared to Caucasians and Chinese population groups. Conclusion We demonstrated no association between -308 TNF

  10. A Phase 3 Placebo-Controlled, Double Blind, Multi-Site Trial of the alpha-2-adrenergic Agonist, Lofexidine, for Opioid Withdrawal

    Science.gov (United States)

    Yu, Elmer; Miotto, Karen; Akerele, Evaristo; Montgomery, Ann; Elkashef, Ahmed; Walsh, Robert; Montoya, Ivan; Fischman, Marian W.; Collins, Joseph; McSherry, Frances; Boardman, Kathy; Davies, David K.; O’Brien, Charles P.; Ling, Walter; Kleber, Herbert; Herman, Barbara H.

    2008-01-01

    Context Lofexidine is an alpha-2-A noradrenergic receptor agonist that is approved in the United Kingdom for the treatment of opioid withdrawal symptoms. Lofexidine has been reported to have more significant effects on decreasing opioid withdrawal symptoms with less hypotension than clonidine. Objective To demonstrate that lofexidine is well tolerated and effective in the alleviation of observationally-defined opioid withdrawal symptoms in opioid dependent individuals undergoing medically supervised opioid detoxification as compared to placebo. Design An inpatient, Phase 3, placebo-controlled, double blind, randomized multi-site trial with three phases: (1) Opioid Agonist Stabilization Phase (days 1–3), (2) Detoxification/Medication or Placebo Phase (days 4–8), and (3) Post Detoxification/Medication Phase (days 9–11). Subjects Sixty-eight opioid dependent subjects were enrolled at three sites with 35 randomized to lofexidine and 33 to placebo. Main Outcome Measure Modified Himmelsbach Opiate Withdrawal Scale (MHOWS) on study day 5 (2nd opioid detoxification treatment day). Results Due to significant findings, the study was terminated early. On the study day 5 MHOWS, subjects treated with lofexidine had significantly lower scores (equating to fewer/less severe withdrawal symptoms) than placebo subjects (Least squares means 19.5 ± 2.1 versus 30.9 ± 2.7; p=0.0019). Lofexidine subjects had significantly better retention in treatment than placebo subjects (38.2% versus 15.2%; Log rank test p=0.01). Conclusions Lofexidine is well tolerated and more efficacious than placebo for reducing opioid withdrawal symptoms in inpatients undergoing medically supervised opioid detoxification. Trial Registration trial registry name A Phase 3 Placebo-Controlled, Double-Blind Multi-Site Trial of Lofexidine for Opiate Withdrawal, registration number NCT00032942, URL for the registry http://clinicaltrials.gov/ct/show/NCT00032942?order=4. PMID:18508207

  11. An evaluation of fusion gain in the compact helical fusion reactor FFHR-c1

    Science.gov (United States)

    Miyazawa, J.; Goto, T.; Sakamoto, R.; Sagara, A.; the FFHR Design Group

    2014-01-01

    A new procedure to predict achievable fusion gain in a sub-ignition fusion reactor is proposed. This procedure uses the direct profile extrapolation (DPE) method based on the gyro-Bohm model. The DPE method has been developed to predict the radial profiles in a fusion reactor sustained without auxiliary heating (i.e., in the self-ignition state) from the experimental data. To evaluate the fusion gain in a fusion reactor sustained with auxiliary heating (i.e., in the sub-ignition state), the DPE method is modified to include the influence of the auxiliary heating. The beta scale factor from experiment to reactor is assumed to be 1. Under this assumption, it becomes reasonable to apply the magnetohydrodynamic (MHD) equilibrium (which is calculated to reproduce the experimental data) to the reactor. At the same time, the MHD stability of the reactor plasma is also guaranteed to a certain extent since that beta was already proven in the experiment. The fusion gain in the helical type nuclear test machine FFHR-c1 has been evaluated using this modified DPE method. FFHR-c1 is basically a large duplication of the Large Helical Device (LHD) with a scale factor of 10/3, which corresponds to the major radius of the helical coils of 13.0 m and the plasma volume of ∼1000 m3. Two options with different magnetic field strengths are considered. The fusion gain in FFHR-c1 extrapolated from a set of radial profile data obtained in LHD ranges from 1 to 7, depending on the profiles used together with the assumptions of the magnetic field strength and the alpha heating efficiency.

  12. The Parameter Space of Magnetized Target Fusion (aka Magneto-Inertial Fusion)

    Science.gov (United States)

    Lindemuth, Irvin

    2016-10-01

    Magnetized Target Fusion (MTF), aka Magneto-Inertial Fusion (MIF), is an approach to fusion that compresses a preformed, magnetized (but not necessarily magnetically confined) plasma with an imploding liner or pusher. MTF/MIF operates in a density regime in between the eleven orders of magnitude (1011) in density that separate inertial confinement fusion (ICF) from magnetic confinement fusion MCF. Compared to MCF, the higher density, shorter confinement times, and compressional heating as the dominant heating mechanism potentially reduce the impact of magnetic instabilities. Compared to ICF, the magnetically reduced thermal transport and lower density leads to orders-of-magnitude reduction in the difficult-to-achieve areal-density parameter and a significant reduction in required implosion velocity and radial convergence, potentially reducing the deleterious effects of implosion hydrodynamic instabilities. This tutorial presents fundamental analysis and simple time-dependent modeling to show where significant fusion gain might be achieved in the intermediate-density regime. The analysis shows that the fusion design space is potentially a continuum between ICF and MCF but practical considerations limit the space in which ignition might be obtained. Generic time-dependent modeling addresses the key physics requirements and defines ``ball-park'' values needed for target-plasma initial density, temperature, and magnetic field and implosion system size, energy, and velocity. The modeling shows energy gains greater than 30 can potentially be achieved and that high gain may be obtained at low convergence ratios, e.g., less than 15. A non-exhaustive review of past and present MTF/MIF efforts is presented and the renewed interest in MTF/MIF within the US (e.g., ARPA-E's ALPHA program) and abroad is noted.

  13. Instruments used to measure or check {alpha}, {beta}, {gamma} activity and neutron emission in the course of processing ore or irradiated fuel; Appareils de mesure ou de controle {alpha}, {beta}, {gamma}, n, des circuits des usines de traitement du minerai ou du combustible irradie

    Energy Technology Data Exchange (ETDEWEB)

    Blanc, A.; Brunet, M.; Kermagoret, M.; Labeyrie, J.; Roux, G.; Vasseur, J.; Weil, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-07-01

    One of the methods checking ores in the course of treatment is the rapid quantitative determination of thorium. This measurement is carried out by means of a scintillation instrument which shows the {beta} and {alpha} coincidences of ThC and ThC'. The treatment of irradiated fuel is accompanied by a large number of radioactive checks relative to the performance of the fixation and elution operations of uranium in the ion exchangers, to the concentration of radioactivity of effluent sent from the plant into watercourses. The operations of fixation and elution of the uranium are checked automatically by an instrument which takes a sample of 5 cm{sup 3} of solution, evaporates it and measures its activity every 10 or 20 minutes. Plutonium concentrations are measured: - in the presence of strong {beta} {gamma} activities, by means of rotating cylinder detectors; - in the presence of weak {beta} {gamma} activities, by means of {alpha} detectors scanning a constant level liquid surface; - by means of fission chambers relatively insensitive to {gamma}. Fission product concentrations are measured by chambers, counters or scintillators, according to the amount of {gamma} activity present. Finally, the activity of effluent to be emptied into watercourses is checked by means of a scintillation instrument, which measures the {alpha} activity on the one hand, and on the other hand the {beta} {gamma} activity of residue from a 100 cm{sup 3} sample taken and evaporated in 20 minutes. (author) [French] Parmi les controles relatifs au minerai en cours de traitement, figure le dosage rapide de thorium. Cette mesure est realisee au moyen d'un appareillage a scintillation qui met en evidence la coincidence des emissions {beta} et {alpha} du ThC et du ThC'. Le traitement des combustibles irradies s'accompagne d'un grand nombre de controles radioactifs portant sur le fonctionnement des operations de fixation et d'elution de l'uranium dans les

  14. Efficacy of Topical Alpha Ointment (Containing Natural Henna Compared to Topical Hydrocortisone (1% in the Healing of Radiation-Induced Dermatitis in Patients with Breast Cancer: A Randomized Controlled Clinical Trial

    Directory of Open Access Journals (Sweden)

    Mansour Ansari

    2013-12-01

    Full Text Available Background: This two-arm, randomized clinical study aimed to compare efficacy between topical Alpha ointment and topical hydrocortisone cream (1% in the healing of radiation-induced dermatitis in breast cancer patients. Methods: The inclusion criteria comprised newly pathologically proven, locally advanced breast cancer (treated with modified radical mastectomy followed by sequential adjuvant treatments, including chest wall radiotherapy [45-50.4 Gy] and grade 2 and/or 3 chest wall dermatitis. The exclusion criteria were comprised of any underlying disease or medications interfering with the wound healing process, previous history of chest wall radiotherapy, and concurrent use of chemotherapy. Sixty eligible patients were randomly assigned to use either topical Alpha ointment (study arm, n=30 or topical hydrocortisone cream (1% (control arm, n=30 immediately after receiving a total dose of 45-50 Gy chest wall radiotherapy. Results: The mean radiation dose was 49.1 Gy in the control arm and 48.8 Gy in the study arm. The mean dermatitis area was 13.54 cm2 in the control arm and 17.02 cm2 in the study arm. Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1% (P=0.001. This effect was significant in the second week (P=0.007. In addition, Alpha ointment decreased the patients’ complaints such as pain (P<0.001, pruritus (P=0.009, and discharge (P=0.010 effectively and meaningfully. Conclusion: Topical Alpha ointment was more effective on the healing of radiation-induced dermatitis than was topical hydrocortisone cream (1% in our patients with breast cancer. Trial Registration Numbers: IRCT201206099979N1 ACTRN12612000837820

  15. Fusion Studies in Japan

    Science.gov (United States)

    Ogawa, Yuichi

    2016-05-01

    A new strategic energy plan decided by the Japanese Cabinet in 2014 strongly supports the steady promotion of nuclear fusion development activities, including the ITER project and the Broader Approach activities from the long-term viewpoint. Atomic Energy Commission (AEC) in Japan formulated the Third Phase Basic Program so as to promote an experimental fusion reactor project. In 2005 AEC has reviewed this Program, and discussed on selection and concentration among many projects of fusion reactor development. In addition to the promotion of ITER project, advanced tokamak research by JT-60SA, helical plasma experiment by LHD, FIREX project in laser fusion research and fusion engineering by IFMIF were highly prioritized. Although the basic concept is quite different between tokamak, helical and laser fusion researches, there exist a lot of common features such as plasma physics on 3-D magnetic geometry, high power heat load on plasma facing component and so on. Therefore, a synergetic scenario on fusion reactor development among various plasma confinement concepts would be important.

  16. Faddeev calculation of 3 alpha and alpha alpha Lambda systems using alpha alpha resonating-group method kernel

    CERN Document Server

    Fujiwara, Y; Kohno, M; Suzuki, Y; Baye, D; Sparenberg, J M

    2004-01-01

    We carry out Faddeev calculations of three-alpha (3 alpha) and two-alpha plus Lambda (alpha alpha Lambda) systems, using two-cluster resonating-group method kernels. The input includes an effective two-nucleon force for the alpha alpha resonating-group method and a new effective Lambda N force for the Lambda alpha interaction. The latter force is a simple two-range Gaussian potential for each spin-singlet and triplet state, generated from the phase-shift behavior of the quark-model hyperon-nucleon interaction, fss2, by using an inversion method based on supersymmetric quantum mechanics. Owing to the exact treatment of the Pauli-forbidden states between the clusters, the present three-cluster Faddeev formalism can describe the mutually related, alpha alpha, 3 alpha and alpha alpha Lambda systems, in terms of a unique set of the baryon-baryon interactions. For the three-range Minnesota force which describes the alpha alpha phase shifts quite accurately, the ground-state and excitation energies of 9Be Lambda are...

  17. Fundamental studies of fusion plasmas. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Aamodt, R.E.

    1998-01-30

    Lodestar has carried out a vigorous research program in the areas of rf, edge plasma and divertor physics, with emphasis largely geared towards improving the understanding and performance of ion-cyclotron heating and current drive (ICRF) systems. Additionally, a research program in the field of edge plasma and divertor modeling was initiated. Theoretical work on high power rf sheath formation for multi-strap rf arrays was developed and benchmarked against recent experimental data from the new JET A2 antennas. Sophisticated modeling tools were employed to understand the sheath formation taking into account realistic three-dimensional antenna geometry. A novel physics explanation of an observed anomaly in the low power loading of antennas was applied to qualitatively interpret data on DIII-D in terms of rf sheaths, and potential applications of the idea to develop a near-field sheath diagnostic were explored. Other rf-wave related topics were also investigated. Full wave ICRF modeling studies were carried out in support of ongoing and planned tokamaks experiments, including the investigation of low frequency plasma heating and current drive regimes for IGNITOR. In a cross-disciplinary study involving both MHD and ICRF physics, ponderomotive feedback stabilization by rf was investigated as a potential means of controlling external kink mode disruptions. In another study, the instability of the ion hybrid wave (IHW) in the presence of fusion alpha particles was studied. In the field of edge plasma and divertor modeling studies, Lodestar began the development of a theory of generalized ballooning and sheath instabilities in the scrape off layer (SOL) of divertor tokamaks. A detailed summary of the technical progress in these areas during the contract period is included, as well as where references to published work can be found. A separate listing of publications, meeting abstracts, and other presentations is also given at the end of this final report.

  18. MFTF-. cap alpha. + T progress report

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, W.D. (ed.)

    1985-04-01

    Early in FY 1983, several upgrades of the Mirror Fusion Test Facility (MFTF-B) at Lawrence Livermore National Laboratory (LLNL) were proposed to the fusion community. The one most favorably received was designated MFTF-..cap alpha..+T. The engineering design of this device, guided by LLNL, has been a principal activity of the Fusion Engineering Design Center during FY 1983. This interim progress report represents a snapshot of the device design, which was begun in FY 1983 and will continue for several years. The report is organized as a complete design description. Because it is an interim report, some parts are incomplete; they will be supplied as the design study proceeds. As described in this report, MFTF-..cap alpha..+T uses existing facilities, many MFTF-B components, and a number of innovations to improve on the physics parameters of MFTF-B. It burns deuterium-tritium and has a central-cell Q of 2, a wall loading GAMMA/sub n/ of 2 MW/m/sup 2/ (with a central-cell insert module), and an availability of 10%. The machine is fully shielded, allows hands-on maintenance of components outside the vacuum vessel 24 h after shutdown, and has provisions for repair of all operating components.

  19. Remote sensing image fusion

    CERN Document Server

    Alparone, Luciano; Baronti, Stefano; Garzelli, Andrea

    2015-01-01

    A synthesis of more than ten years of experience, Remote Sensing Image Fusion covers methods specifically designed for remote sensing imagery. The authors supply a comprehensive classification system and rigorous mathematical description of advanced and state-of-the-art methods for pansharpening of multispectral images, fusion of hyperspectral and panchromatic images, and fusion of data from heterogeneous sensors such as optical and synthetic aperture radar (SAR) images and integration of thermal and visible/near-infrared images. They also explore new trends of signal/image processing, such as

  20. Validating modelling assumptions of alpha particles in electrostatic turbulence

    CERN Document Server

    Wilkie, George; Highcock, Edmund; Dorland, William

    2014-01-01

    To rigorously model fast ions in fusion plasmas, a non-Maxwellian equilibrium distribution must be used. In the work, the response of high-energy alpha particles to electrostatic turbulence has been analyzed for several different tokamak parameters. Our results are consistent with known scalings and experimental evidence that alpha particles are generally well-confined: on the order of several seconds. It is also confirmed that the effect of alphas on the turbulence is negligible at realistically low concentrations, consistent with linear theory. It is demonstrated that the usual practice of using a high-temperature Maxwellian gives incorrect estimates for the radial alpha particle flux, and a method of correcting it is provided. Furthermore, we see that the timescales associated with collisions and transport compete at moderate energies, calling into question the assumption that alpha particles remain confined to a flux surface that is used in the derivation of the slowing-down distribution.

  1. Higgs production in gluon fusion beyond NNLO

    CERN Document Server

    Ball, Richard D; Forte, Stefano; Marzani, Simone; Ridolfi, Giovanni

    2013-01-01

    We construct an approximate expression for the cross section for Higgs production in gluon fusion at next-to-next-to-next-to-leading order (N3LO) in alpha_s with finite top mass. We argue that an accurate approximationcan be constructed by exploiting the analiticity of the Mellin space cross section, and the information on its singularity structure coming from large N (soft gluon, Sudakov) and small N (high energy, BFKL) all order resummation. We support our argument with an explicit comparison of the approximate and the exact expressions up to the highest (NNLO) order at which the latter are available. We find that the approximate N3LO result amounts to a correction of 17% to the NNLO QCD cross section for production of a 125 GeV Higgs at the LHC (8 TeV), larger than previously estimated, and it significantly reduces the scale dependence of the NNLO result.

  2. Alpha Thalassemia (For Parents)

    Science.gov (United States)

    ... Kids to Be Smart About Social Media Alpha Thalassemia KidsHealth > For Parents > Alpha Thalassemia Print A A ... Complications Symptoms Diagnosis Treatment en español Alfa talasemia Thalassemias Thalassemias are a group of blood disorders that ...

  3. Two-stream cyclotron radiative instabilities due to the marginally mirror-trapped fraction for fustion alphas in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Arunasalam, V.

    1995-07-01

    It is shown here that the marginally mirror-trapped fraction of the newly-born fusion alpha particles in the deuterium-tritium (DT) reaction dominated tokamak plasmas can induce a two-stream cyclotron radiative instability for the fast Alfven waves propagating near the harmonics of the alpha particle cyclotron frequency {omega}{sub c{alpha}}. This can explain both the experimentally observed time behavior and the spatially localized origin of the fusion product ion cyclotron emission (ICE) in TFTR at frequencies {omega} {approx} m{omega}{sub c{alpha}}.

  4. Plasma engineering studies for Tennessee Tokamak (TENTOK) fusion power reactor

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, K.E.; Lacatski, J.T.; Miller, J.B.; Bryan, W.E.; King, P.W.; Santoro, R.T.; Uckan, N.A.; Shannon, T.E.

    1984-02-01

    This paper summarizes the results of the plasma engineering and systems analysis studies for the Tennessee Tokamak (TENTOK) fusion power reactor. TENTOK is a 3000-MW(t) central station power plant that uses deuterium-tritium fuel in a D-shaped tokamak plasma configuration with a double-null poloidal divertor. The major parameters are R/sub 0/ = 6.4 m, a = 1.6 m, sigma (elongation) = 1.65, (n) = 1.5 x 10/sup 20/ m/sup -3/, (T) = 15 keV, (..beta..) = 6%, B/sub T/ (on-axis) = 5.6 T, I/sub p/ = 8.5 MA, and wall loading = 3 MW/m/sup 2/. Detailed analyses are performed in the areas of (1) transport simulation using the one-and-one-half-dimensional (1-1/2-D) WHIST transport code, (2) equilibrium/poloidal field coil systems, (3) neutral beam and radiofrequency (rf) heating, and (4) pellet fueling. In addition, impurity control systems, diagnostics and controls, and possible microwave plasma preheating and steady-state current drive options are also considered. Some of the major features of TENTOK include rf heating in the ion cyclotron range of frequencies, superconducting equilibrium field coils outside the superconducting toroidal field coils, a double-null poloidal divertor for impurity control and alpha ash removal, and rf-assisted plasma preheating and current startup.

  5. The Alpha Antihydrogen Experiment

    Science.gov (United States)

    Madsen, N.; Andresen, G.; Bertsche, W.; Boston, A.; Bowe, P. D.; Butler, E.; Cesar, C. L.; Chapman, S.; Charlton, M.; Chartier, M.; Fajans, J.; Funakoshi, R.; Gill, D. R.; Hangst, J. S.; Hardy, W. N.; Hayano, R. S.; Hayden, M.; Hydomako, R.; Jenkins, M. J.; Jørgensen, L. V.; Kurchaninov, L.; Nolan, P.; Olchanski, K.; Olin, A.; Page, R. D.; Povilus, A.; Robicheaux, F.; Sarid, E.; Seif El Nasr, S.; Silveira, D. M.; Storey, J. W.; Thompson, R. I.; van der Werf, D. P.; Wurtele, J. S.; Yamazaki, Y.

    2008-03-01

    ALPHA is a new experiment at the CERN Antiproton Decelerator (AD). The short term goal of ALPHA is trapping of cold antihydrogen, with the long term goal of conducting precise spectroscopic comparisons of hydrogen and antihydrogen. Here we present the current status of ALPHA and the physics considerations and results leading to its design as well as recent progress towards trapping.

  6. An amphipathic alpha-helix controls multiple roles of brome mosaic virus protein 1a in RNA replication complex assembly and function.

    Directory of Open Access Journals (Sweden)

    Ling Liu

    2009-03-01

    Full Text Available Brome mosaic virus (BMV protein 1a has multiple key roles in viral RNA replication. 1a localizes to perinuclear endoplasmic reticulum (ER membranes as a peripheral membrane protein, induces ER membrane invaginations in which RNA replication complexes form, and recruits and stabilizes BMV 2a polymerase (2a(Pol and RNA replication templates at these sites to establish active replication complexes. During replication, 1a provides RNA capping, NTPase and possibly RNA helicase functions. Here we identify in BMV 1a an amphipathic alpha-helix, helix A, and use NMR analysis to define its structure and propensity to insert in hydrophobic membrane-mimicking micelles. We show that helix A is essential for efficient 1a-ER membrane association and normal perinuclear ER localization, and that deletion or mutation of helix A abolishes RNA replication. Strikingly, mutations in helix A give rise to two dramatically opposite 1a function phenotypes, implying that helix A acts as a molecular switch regulating the intricate balance between separable 1a functions. One class of helix A deletions and amino acid substitutions markedly inhibits 1a-membrane association and abolishes ER membrane invagination, viral RNA template recruitment, and replication, but doubles the 1a-mediated increase in 2a(Pol accumulation. The second class of helix A mutations not only maintains efficient 1a-membrane association but also amplifies the number of 1a-induced membrane invaginations 5- to 8-fold and enhances viral RNA template recruitment, while failing to stimulate 2a(Pol accumulation. The results provide new insights into the pathways of RNA replication complex assembly and show that helix A is critical for assembly and function of the viral RNA replication complex, including its central role in targeting replication components and controlling modes of 1a action.

  7. 17-alpha-hydroxyprogesterone caproate versus vaginal progesterone suppository for the prevention of preterm birth in women with a sonographically short cervix: A randomized controlled trial.

    Science.gov (United States)

    Pirjani, Reihaneh; Heidari, Reza; Rahimi-Foroushani, Abbas; Bayesh, Seyedehsara; Esmailzadeh, Arezoo

    2017-01-01

    The aim of this study was to compare 17-alpha-hydroxyprogesterone caproate (17OHP-C) with vaginal progesterone suppository for the prevention of preterm birth in women with a sonographically short cervix and to evaluate the changes of the cervical length (CL) over time. In this prospective randomized controlled trial, eligible patients were asymptomatic pregnant women with a sonographically short cervix. The participants in group 1 (n = 147) received vaginal progesterone suppositories at a dose of 400 mg daily and the women in group 2 (n = 150) received an i.m. dose of 250 mg 17OHP-C once a week. Transvaginal sonography was repeated every 3 weeks until 36 gestational weeks or the occurrence of preterm labor. A total of 304 singleton pregnant women between 16 and 24 gestational weeks with CL < 25 mm were enrolled in our study. The rates of preterm birth were 10.4% in the progesterone group and 14% in the 17OHP-C group: a difference that was not statistically significant (P = 0.416). Moreover, 264 participants underwent ultrasound examination five times and CL changes were studied for 15 weeks. The results showed that the CL changes over 15 weeks were statistically significant (P < 0.001), but the method of intervention (progesterone/17OHP-C) had no significant effect on CL change (P = 0.64). Our findings showed that vaginal progesterone and 17OHP-C had the same effect on the risk of preterm labor in asymptomatic women with a sonographically short cervix. We detected no significant difference between the effect of 17OHP-C and vaginal progesterone on CL changes over time. © 2016 Japan Society of Obstetrics and Gynecology.

  8. Sampling Based Average Classifier Fusion

    Directory of Open Access Journals (Sweden)

    Jian Hou

    2014-01-01

    fusion algorithms have been proposed in literature, average fusion is almost always selected as the baseline for comparison. Little is done on exploring the potential of average fusion and proposing a better baseline. In this paper we empirically investigate the behavior of soft labels and classifiers in average fusion. As a result, we find that; by proper sampling of soft labels and classifiers, the average fusion performance can be evidently improved. This result presents sampling based average fusion as a better baseline; that is, a newly proposed classifier fusion algorithm should at least perform better than this baseline in order to demonstrate its effectiveness.

  9. Space Station alpha joint bearing

    Science.gov (United States)

    Everman, Michael R.; Jones, P. Alan; Spencer, Porter A.

    1987-01-01

    Perhaps the most critical structural system aboard the Space Station is the Solar Alpha Rotary Joint which helps align the power generation system with the sun. The joint must provide structural support and controlled rotation to the outboard transverse booms as well as power and data transfer across the joint. The Solar Alpha Rotary Joint is composed of two transition sections and an integral, large diameter bearing. Alpha joint bearing design presents a particularly interesting problem because of its large size and need for high reliability, stiffness, and on orbit maintability. The discrete roller bearing developed is a novel refinement to cam follower technology. It offers thermal compensation and ease of on-orbit maintenance that are not found in conventional rolling element bearings. How the bearing design evolved is summarized. Driving requirements are reviewed, alternative concepts assessed, and the selected design is described.

  10. Fusion plasma physics

    CERN Document Server

    Stacey, Weston M

    2012-01-01

    This revised and enlarged second edition of the popular textbook and reference contains comprehensive treatments of both the established foundations of magnetic fusion plasma physics and of the newly developing areas of active research. It concludes with a look ahead to fusion power reactors of the future. The well-established topics of fusion plasma physics -- basic plasma phenomena, Coulomb scattering, drifts of charged particles in magnetic and electric fields, plasma confinement by magnetic fields, kinetic and fluid collective plasma theories, plasma equilibria and flux surface geometry, plasma waves and instabilities, classical and neoclassical transport, plasma-materials interactions, radiation, etc. -- are fully developed from first principles through to the computational models employed in modern plasma physics. The new and emerging topics of fusion plasma physics research -- fluctuation-driven plasma transport and gyrokinetic/gyrofluid computational methodology, the physics of the divertor, neutral ...

  11. Laser-Driven Fusion.

    Science.gov (United States)

    Gibson, A. F.

    1980-01-01

    Discusses the present status and future prospects of laser-driven fusion. Current research (which is classified under three main headings: laser-matter interaction processes, compression, and laser development) is also presented. (HM)

  12. Fusion Revisits CERN

    CERN Multimedia

    2001-01-01

    It's going to be a hot summer at CERN. At least in the Main Building, where from 13 July to 20 August an exhibition is being hosted on nuclear fusion, the energy of the Stars. Nuclear fusion is the engine driving the stars but also a potential source of energy for mankind. The exhibition shows the different nuclear fusion techniques and research carried out on the subject in Europe. Inaugurated at CERN in 1993, following collaboration between Lausanne's CRPP-EPFL and CERN, with input from Alessandro Pascolini of Italy's INFN, this exhibition has travelled round Europe before being revamped and returning to CERN. 'Fusion, Energy of the Stars', from 13 July onwards, Main Building

  13. Optical Fiber Fusion Splicing

    CERN Document Server

    Yablon, Andrew D

    2005-01-01

    This book is an up-to-date treatment of optical fiber fusion splicing incorporating all the recent innovations in the field. It provides a toolbox of general strategies and specific techniques that the reader can apply when optimizing fusion splices between novel fibers. It specifically addresses considerations important for fusion splicing of contemporary specialty fibers including dispersion compensating fiber, erbium-doped gain fiber, polarization maintaining fiber, and microstructured fiber. Finally, it discusses the future of optical fiber fusion splicing including silica and non-silica based optical fibers as well as the trend toward increasing automation. Whilst serving as a self-contained reference work, abundant citations from the technical literature will enable readers to readily locate primary sources.

  14. Perceptual reasoning in adaptive fusion processing

    Science.gov (United States)

    Kadar, Ivan

    2002-07-01

    The author previously published a unified perceptual reasoning system framework for adaptive sensor fusion and situation assessment. Ths framework is re-examined to highlight the role of human perceptual reasoning and to establish the relationship between human perceptual reasoning and the Joint Director of Laboratories (JDL) fusion levels. Mappings between the fusion levels and the elements of perceptual reasoning are defined. Methods to populate the knowledge bases associated with each component of the perceptual reasoning system are highlighted. The concept and application of perception, the resultant system architecture and its candidate renditions using distributed interacting software agents (ISA) are discussed. The perceptual reasoning system is shown to be a natural governing mechanism for extracting, associating and fusing information from multiple sources while adaptively controlling the fusion level processes for optimum fusion performance. The unified modular system construct is shown to provide a formal framework to accommodate various implementation alternatives. The application of this architectural concept is illustrated for distributed fusion systems architectures and is sued to illustrate the benefits of the adaptive perceptual reasoning system concept.

  15. Economically competitive fusion

    Directory of Open Access Journals (Sweden)

    David J. Ward

    2008-12-01

    Full Text Available Not since the oil crisis of the 1970s has the perception that energy is a crucial and precious resource been as strong as it is today. The need for a new approach to world energy supply, driven by concerns over resources, pollution, and security, is leading to a reappraisal of fusion. Fusion has enormous potential and major safety and environmental advantages, and hence could make a large difference to energy supplies.

  16. Fusion, cold fusion, and space policy

    Energy Technology Data Exchange (ETDEWEB)

    Rotegard, D. (CST Ltd. (United States))

    1991-01-01

    This paper critiques Americal science policy through a consideration of two examples-cold fusion and asteroid mining. It points out that the failure of central planning in science and technology policy is just as marked as in more mundane activities. It highlights the current low level of debate and points out some technical issues that need to be addressed. It concludes with evidence that the alliance of flawed policy options is further lowering the level of debate. (author).

  17. Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats.

    Science.gov (United States)

    Frye, Cheryl A; Rhodes, Madeline E

    2008-02-11

    17beta-Estradiol (E2) and progesterone (P4) influence the onset and duration of sexual behavior and are also associated with changes in behaviors that may contribute to mating, such as exploration, anxiety, and social behaviors (socio-sexual behaviors). In the midbrain ventral tegmental area (VTA), the P4 metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), modulates lordosis of E2-primed rodents; 3alpha,5alpha-THP can also influence anxiety and social behaviors. To examine if 3alpha,5alpha-THP in the VTA mediates socio-sexual behaviors, we infused 3alpha,5alpha-THP to the VTA of diestrous and proestrous rats. As expected, proestrous, compared to diestrous, rats showed more exploratory (open field), anxiolytic (elevated plus maze), pro-social (partner preference, social interaction), and sexual (paced mating) behavior and had increased E2, P4, dihydroprogesterone (DHP), and 3alpha,5alpha-THP in serum, midbrain, hippocampus, diencephalon, and cortex. Infusions of 3alpha,5alpha-THP to the VTA, but not control sites, such as the substantia nigra (SN) or central grey (CG), of diestrous rats produced behavioral and endocrine effects akin to that of proestrous rats and increased DHP and 3alpha,5alpha-THP levels in midbrain, hippocampus, and diencephalon. Levels of DHP and 3alpha,5alpha-THP, but neither E2 nor P4 concentrations, in midbrain, hippocampus, diencephalon, and/or cortex were positively correlated with socio-sexual behaviors. Thus, 3alpha,5alpha-THP infusions to the VTA, but not SN or CG, can enhance socio-sexual behaviors and increase levels in midbrain, hippocampus, and diencephalon.

  18. V-ATPase, ScNhxlp and Yeast Vacuole Fusion

    Institute of Scientific and Technical Information of China (English)

    Quan-Sheng Qiu

    2012-01-01

    Membrane fusion is the last step in trafficking pathways during which membrane vesicles fuse with target organelles to deliver cargos.It is a central cellular reaction that plays important roles in signal transduction,protein sorting and subcellular compartmentation.Recent progress in understanding the roles of ion transporters in vacuole fusion in yeast is summanzed in this article.It is becoming increasingly evident that the vacuolar proton pump V-ATPase and vacuolar Na+/H+ antiporter ScNhxlp are key components of the vacuole fusion machinery in yeast.Yeast ScNhxlp regulates vacuole fusion by controlling the luminal pH.V-ATPases serve a dual role in vacuolar integrity in which they regulate both vacuole fusion and fission reactions in yeast.Fission defects are epistatic to fusion defects.Vacuole fission depends on the proton translocation activity of the V-ATPase; by contrast,the fusion reaction does not need the transport activity but requires the physical presence of the proton pump.Vo,the membrane-integral sector of the V-ATPase,forms trans-complexes between the opposing vacuoles in the terminal phase of vacuole fusion where the Vo trans-complexes build a continuous proteolipid channel at the fusion site to mediate the bilayer fusion.

  19. Morphology and crystal structure control of alpha-Fe2O3 films by hydrothermal-electrochemical deposition in the presence of Ce3+ and/or acetate, F- ions

    OpenAIRE

    Yılmaz, Özgür; Ünal, Uğur

    2016-01-01

    Hydrothermal-electrochemical growth of Hematite (alpha-Fe2O3) thin films in the presence of Ce3+ and/or CH3COO- and F- ions is reported. Primary attention is paid to understanding the synergistic effect of temperature and additive ions on the growth of Hematite particles. The literature describes the shape-controlled electrodeposition of iron oxide films, but these reports involve low-temperature depositions (

  20. Nuclear Fusion Research Understanding Plasma-Surface Interactions

    CERN Document Server

    Clark, Robert E.H

    2005-01-01

    It became clear in the early days of fusion research that the effects of the containment vessel (erosion of "impurities") degrade the overall fusion plasma performance. Progress in controlled nuclear fusion research over the last decade has led to magnetically confined plasmas that, in turn, are sufficiently powerful to damage the vessel structures over its lifetime. This book reviews current understanding and concepts to deal with this remaining critical design issue for fusion reactors. It reviews both progress and open questions, largely in terms of available and sought-after plasma-surface interaction data and atomic/molecular data related to these "plasma edge" issues.

  1. Quantum propagator approach to heavy-ion fusion

    Energy Technology Data Exchange (ETDEWEB)

    Bao, J.D. [Beijing Univ., BJ (China). Dept. of Physics; Boiley, D.; Bao, J.D. [Grand Accelerateur National d' Ions Lourds (GANIL), 14 - Caen (France)

    2002-07-01

    The real-time path integral propagator approach is used to study the fusion probability of massive nuclei including quantum effect. An analytical expression of the probability to pass over barrier of an inverted harmonic potential is obtained, in which both height and curvature of the barrier are controlled by the neck degree of freedom. The fusion probability of three systems in central collision as a function of the center of mass energy are calculated and compared to experimental results. It is shown that the quantum fluctuation enhances the fusion probability at low energies, and the neck fluctuation makes the slope of the fusion probability curve become flatter. (author)

  2. Color Multifocus Image Fusion Using Empirical Mode Decomposition

    Directory of Open Access Journals (Sweden)

    S. Savić

    2013-11-01

    Full Text Available In this paper, a recently proposed grayscale multifocus image fusion method based on the first level of Empirical Mode Decomposition (EMD has been extended to color images. In addition, this paper deals with low contrast multifocus image fusion. The major advantages of the proposed methods are simplicity, absence of artifacts and control of contrast, while this isn’t the case with other pyramidal multifocus fusion methods. The efficiency of the proposed method is tested subjectively and with a vector gradient based objective measure, that is proposed in this paper for multifocus color image fusion. Subjective analysis performed on a multifocus image dataset has shown its superiority to the existing EMD and DWT based methods. The objective measures of grayscale and color image fusion show significantly better scores for this method than for the classic complex EMD fusion method.

  3. Dimerization of A-[alpha]-[SiNb3W9O40]7- by pH-controlled formation of individual Nb−µ-O−Nb linkages

    Science.gov (United States)

    Gyu-Shik Kim; Huadong Zeng; Wade A. Neiwert; Jennifer J. Cowan; Donald VanDerveer; Craig L. Hill; Ira A. Weinstock

    2003-01-01

    The reversible, stepwise formation of individual Nb−µ-O−Nb linkages during acid condensation of 2 equiv of A-[alpha]-[SiNb3W9O40]7- (1) to the tri-µ-oxo-bridged structure A-[alpha]-[Si2Nb6W18O77]8- (4) is demonstrated by a combination of X-ray crystallography and variable-pD solution 183W and 29Si NMR spectroscopy. Addition of DCl to a pD 8.4...

  4. MHD control in burning plasmas MHD control in burning plasmas

    Science.gov (United States)

    Donné, Tony; Liang, Yunfeng

    2012-07-01

    Fusion physics focuses on the complex behaviour of hot plasmas confined by magnetic fields with the ultimate aim to develop a fusion power plant. In the future generation of tokamaks like ITER, the power generated by the fusion reactions substantially exceeds the external input power (Pfusion}/Pin >= 10). When this occurs one speaks of a burning plasma. Twenty per cent of the generated fusion power in a burning plasma is carried by the charged alpha particles, which transfer their energy to the ambient plasma in collisions, a process called thermalization. A new phenomenon in burning plasmas is that the alpha particles, which form a minority but carry a large fraction of the plasma kinetic energy, can collectively drive certain types of magneto-hydrodynamic (MHD) modes, while they can suppress other MHD modes. Both types of MHD modes can have desirable effects on the plasma, as well as be detrimental to the plasma. For example, the so-called sawtooth instability, on the one hand, is largely responsible for the transport of the thermalized alpha particles out of the core, but, on the other hand, may result in the loss of the energetic alphas before they have fully thermalized. A further undesirable effect of the sawtooth instability is that it may trigger other MHD modes such as neoclassical tearing modes (NTMs). These NTMs, in turn, are detrimental to the plasma confinement and in some cases may even lead to disruptive termination of the plasma. At the edge of the plasma, finally, so-called edge localized modes or ELMs occur, which result in extremely high transient heat and particle loads on the plasma-facing components of a reactor. In order to balance the desired and detrimental effects of these modes, active feedback control is required. An additional complication occurs in a burning plasma as the external heating power, which is nowadays generally used for plasma control, is small compared to the heating power of the alpha particles. The scientific challenge

  5. The determination of $\\alpha_s$ by the ALPHA collaboration

    CERN Document Server

    Bruno, Mattia

    2016-01-01

    We review the ALPHA collaboration strategy for obtaining the QCD coupling at high scale. In the three-flavor effective theory it avoids the use of perturbation theory at $\\alpha > 0.2$ and at the same time has the physical scales small compared to the cutoff $1/a$ in all stages of the computation. The result $\\Lambda_\\overline{MS}^{(3)}=332(14)$~MeV is translated to $\\alpha_\\overline{MS}(m_Z)=0.1179(10)(2)$ by use of (high order) perturbative relations between the effective theory couplings at the charm and beauty quark "thresholds". The error of this perturbative step is discussed and estimated as $0.0002$.

  6. Comparison of fusion rate and clinical results between CaO-SiO2-P2O5-B2O3 bioactive glass ceramics spacer with titanium cages in posterior lumbar interbody fusion.

    Science.gov (United States)

    Lee, Jae Hyup; Kong, Chang-Bae; Yang, Jae Jun; Shim, Hee-Jong; Koo, Ki-Hyoung; Kim, Jeehyoung; Lee, Choon-Ki; Chang, Bong-Soon

    2016-11-01

    The CaO-SiO2-P2O5-B2O3 glass ceramics spacer generates chemical bonding to adjacent bones with high mechanical stability to produce a union with the end plate, and ultimately stability. The authors aimed to compare the clinical efficacy and safety of CaO-SiO2-P2O5-B2O3 glass ceramics with a titanium cage that is widely used for posterior lumbar interbody fusion (PLIF) surgery in the clinical field. This is a prospective, stratified randomized, multicenter, single-blinded, comparator-controlled non-inferiority trial. The present study was conducted in four hospitals and enrolled a total of 86 patients between 30 and 80 years of age who required one-level PLIF due to severe spinal stenosis, spondylolisthesis, or huge disc herniation. The Oswestry Disability Index (ODI), Short Form-36 Health Survey (SF-36), and pain visual analog scale (VAS) were assessed before surgery and at 3, 6, and 12 months after surgery. The spinal fusion rate was assessed at 6 and 12 months after surgery. The spinal fusion rate and the area of fusion, subsidence of each CaO-SiO2-P2O5-B2O3 glass ceramics and titanium cage, and the extent of osteolysis were evaluated using a dynamic plain radiography and a three-dimensional computed tomography at 12 months after surgery. The present study was supported by BioAlpha, and some authors (JHL, C-KL, and B-SC) have stock ownership (glass ceramics group and the titanium group were 89.7% and 91.4%, respectively. In addition, the 12-month fusion rates based on CT scan were 89.7% and 91.2%, respectively, showing no significant difference. However, the bone fusion area directly attached to the end plate of either bioactive glass ceramics or the titanium cage was significantly higher in the bioactive glass ceramics group than in the titanium group. The ODI, SF-36, back pain, and lower limb pain in both groups significantly improved after surgery, with no significant differences between the groups. No significant differences between the two groups were

  7. Materials issues in fusion reactors

    Science.gov (United States)

    Suri, A. K.; Krishnamurthy, N.; Batra, I. S.

    2010-02-01

    The world scientific community is presently engaged in one of the toughest technological tasks of the current century, namely, exploitation of nuclear fusion in a controlled manner for the benefit of mankind. Scientific feasibility of controlled fusion of the light elements in plasma under magnetic confinement has already been proven. International efforts in a coordinated and co-operative manner are presently being made to build ITER - the International Thermonuclear Experimental Reactor - to test, in this first step, the concept of 'Tokamak' for net fusion energy production. To exploit this new developing option of making energy available through the route of fusion, India too embarked on a robust fusion programme under which we now have a working tokamak - the Aditya and a steady state tokamak (SST-1), which is on the verge of functioning. The programme envisages further development in terms of making SST-2 followed by a DEMO and finally the fusion power reactor. Further, with the participation of India in the ITER program in 2005, and recent allocation of half - a - port in ITER for placing our Lead - Lithium Ceramic Breeder (LLCB) based Test Blanket Module (TBM), meant basically for breeding tritium and extracting high grade heat, the need to understand and address issues related to materials for these complex systems has become all the more necessary. Also, it is obvious that with increasing power from the SST stages to DEMO and further to PROTOTYPE, the increasing demands on performance of materials would necessitate discovery and development of new materials. Because of the 14.1 MeV neutrons that are generated in the D+T reaction exploited in a tokamak, the materials, especially those employed for the construction of the first wall, the diverter and the blanket segments, suffer crippling damage due to the high He/dpa ratios that result due to the high energy of the neutrons. To meet this challenge, the materials that need to be developed for the tokamaks

  8. Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control.

    Science.gov (United States)

    Ruiz-Riol, M; Berdnik, D; Llano, A; Mothe, B; Gálvez, C; Pérez-Álvarez, S; Oriol-Tordera, B; Olvera, A; Silva-Arrieta, S; Meulbroek, M; Pujol, F; Coll, J; Martinez-Picado, J; Ganoza, C; Sanchez, J; Gómez, G; Wyss-Coray, T; Brander, C

    2017-08-15

    blood is a key conduit for transporting such factors. Investigating the communication factors promoting effective immune responses and having potentially antiviral functions against HIV using a novel focused omics approach ("communicome") has the potential to significantly improve our knowledge of effective host immunity and accelerate the HIV cure agenda. Including 140 subjects with variable viral loads and measuring the plasma levels of >600 soluble proteins, our data highlight the importance of Th17 cells and Wnt/β-catenin signaling in HIV control and especially identify the IL-27/IL-27 receptor subunit alpha (IL-27RA) axis as a predictor of plasma viral load and proviral copy number in the peripheral blood. These data may provide important guidance to therapeutic approaches in the HIV cure agenda. Copyright © 2017 Ruiz-Riol et al.

  9. Vitreous advanced glycation endproducts and alpha-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls

    NARCIS (Netherlands)

    Fokkens, Bernardina T.; Mulder, Douwe J.; Schalkwijk, Casper G.; Scheijen, Jean L.; Smit, Andries J.; Los, Leonoor I.

    2017-01-01

    Purpose Advanced glycation endproducts (AGEs) and their precursors alpha-dicarbonyls are implicated in the progression of diabetic retinopathy. The purpose of this study was to assess AGEs and a-dicarbonyls in the vitreous of patients with type 2 diabetes mellitus (T2DM) with early stages or absence

  10. A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth

    DEFF Research Database (Denmark)

    Chaurasia, Pratima; Aguirre-Ghiso, Julio; Liang, Olin D

    2006-01-01

    Highly expressed urokinase plasminogen activator receptor (uPAR) can interact with alpha5beta1 integrin leading to persistent ERK activation and tumorigenicity. Disrupting this interaction reduces ERK activity, forcing cancer cells into dormancy. We identified a site in uPAR domain III that is in......Highly expressed urokinase plasminogen activator receptor (uPAR) can interact with alpha5beta1 integrin leading to persistent ERK activation and tumorigenicity. Disrupting this interaction reduces ERK activity, forcing cancer cells into dormancy. We identified a site in uPAR domain III...... that is indispensable for these effects. A 9-mer peptide derived from a sequence in domain III (residues 240-248) binds purified alpha5beta1 integrin. Substituting a single amino acid (S245A) in this peptide, or in full-length soluble uPAR, impairs binding of the purified integrin. In the recently solved crystal...... structure of uPAR the Ser-245 is confined to the large external surface of the receptor, a location that is well separated from the central urokinase plasminogen binding cavity. The impact of this site on alpha5beta1 integrin-dependent cell functions was examined by comparing cells induced to express u...

  11. Role of alpha adrenoceptors in the nucleus accumbens in the control of accumbal noradrenaline efflux: a microdialysis study with freely moving rats.

    NARCIS (Netherlands)

    Aono, Y.; Saigusa, T.; Watanabe, S.; Iwakami, T.; Mizoguchi, N.; Ikeda, H.; Ishige, K.; Tomiyama, K.; Oi, Y.; Ueda, K.; Rausch, W.D.; Waddington, J.L.; Ito, Y.; Koshikawa, N.; Cools, A.R.

    2007-01-01

    Microdialysis technique was used to study the effects of the locally applied alpha adrenoceptor agonist phenylephrine and antagonist phentolamine on the basal noradrenaline efflux as well as on the noradrenaline uptake inhibitor desipramine-elicited noradrenaline efflux in the nucleus accumbens (NAc

  12. Effects of the. cap alpha. -adrenoceptor antagonists phentolamine, phenoxybenzamine, and Idazoxan on sympathetic blood flow control in the periodontal ligament of the cat

    Energy Technology Data Exchange (ETDEWEB)

    Edwall, B.; Gazelius, B.

    1988-01-01

    Blood flow changes in the periodontal ligament (PDL) were measured indirectly by monitoring the local clearance of /sup 125/I/sup -/ during electric sympathetic nerve stimulation or close intra-arterial infusions of either noradrenaline (NA) or adrenaline (ADR) before and after administration of phentolamine (PA), phenoxybenzamine (PBZ) or Idazoxan (RX). At the doses used in the present study, PA was the only antagonist that significantly reduced the blood flow decrease seen on activation of sympathetic fibers, although PBZ also reduced this response. Idazoxan, however, did not induce the consistent effect on blood flow decreases seen on sympathetic activation. All three ..cap alpha..-adrenoceptor antagonists almost abolished the effects of exogenously administered NA and ADR. The results suggest the presence of functional post-junctional adrenoceptors of both the ..cap alpha.. 1 and ..cap alpha.. 2 subtypes in the sympathetic regulation of the blood flow in the PDL of the cat. A component of the response elicited by electrical sympathetic stimulation appeared to be resistant to ..cap alpha..-adrenoceptor blockade. Administration of guanethidine (which inhibits further release of NA and neuropeptide Y) after PA abolished this residual sympathetic response. 32 refs.

  13. Myoblast fusion in Drosophila

    Energy Technology Data Exchange (ETDEWEB)

    Haralalka, Shruti [Stowers Institute for Medical Research, Kansas City, MO 64110 (United States); Abmayr, Susan M., E-mail: sma@stowers.org [Stowers Institute for Medical Research, Kansas City, MO 64110 (United States); Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, MO 66160 (United States)

    2010-11-01

    The body wall musculature of a Drosophila larva is composed of an intricate pattern of 30 segmentally repeated muscle fibers in each abdominal hemisegment. Each muscle fiber has unique spatial and behavioral characteristics that include its location, orientation, epidermal attachment, size and pattern of innervation. Many, if not all, of these properties are dictated by founder cells, which determine the muscle pattern and seed the fusion process. Myofibers are then derived from fusion between a specific founder cell and several fusion competent myoblasts (FCMs) fusing with as few as 3-5 FCMs in the small muscles on the most ventral side of the embryo and as many as 30 FCMs in the larger muscles on the dorsal side of the embryo. The focus of the present review is the formation of the larval muscles in the developing embryo, summarizing the major issues and players in this process. We have attempted to emphasize experimentally-validated details of the mechanism of myoblast fusion and distinguish these from the theoretically possible details that have not yet been confirmed experimentally. We also direct the interested reader to other recent reviews that discuss myoblast fusion in Drosophila, each with their own perspective on the process . With apologies, we use gene nomenclature as specified by Flybase (http://flybase.org) but provide Table 1 with alternative names and references.

  14. Lateral Lumbar Interbody Fusion

    Science.gov (United States)

    Hughes, Alexander; Girardi, Federico; Sama, Andrew; Lebl, Darren; Cammisa, Frank

    2015-01-01

    The lateral lumbar interbody fusion (LLIF) is a relatively new technique that allows the surgeon to access the intervertebral space from a direct lateral approach either anterior to or through the psoas muscle. This approach provides an alternative to anterior lumbar interbody fusion with instrumentation, posterior lumbar interbody fusion, and transforaminal lumbar interbody fusion for anterior column support. LLIF is minimally invasive, safe, better structural support from the apophyseal ring, potential for coronal plane deformity correction, and indirect decompression, which have has made this technique popular. LLIF is currently being utilized for a variety of pathologies including but not limited to adult de novo lumbar scoliosis, central and foraminal stenosis, spondylolisthesis, and adjacent segment degeneration. Although early clinical outcomes have been good, the potential for significant neurological and vascular vertebral endplate complications exists. Nevertheless, LLIF is a promising technique with the potential to more effectively treat complex adult de novo scoliosis and achieve predictable fusion while avoiding the complications of traditional anterior surgery and posterior interbody techniques. PMID:26713134

  15. Transport and deceleration of fusion products in microturbulence

    Science.gov (United States)

    Wilkie, George J.; Abel, Ian G.; Landreman, Matt; Dorland, William

    2016-06-01

    The velocity-space distribution of alpha particles born in fusion devices is subject to modification at moderate energies due to turbulent transport. Therefore, one must calculate the evolution of an equilibrium distribution whose functional form is not known a priori. Using a novel technique, applicable to any trace impurity, we have made this calculation for fully nonlinear gyrokinetic simulations not only possible but also particularly efficient. We demonstrate a microturbulence-induced departure from the local slowing-down distribution, an inversion of the energy distribution, and associated modifications to the alpha heating and pressure profiles in an ITER-like scenario.

  16. Transport and deceleration of fusion products in microturbulence

    CERN Document Server

    Wilkie, George J; Landreman, Matt; Dorland, William

    2016-01-01

    The velocity-space distribution of alpha particles born in fusion devices is subject to modification at moderate energies due to turbulent transport. Therefore, one must calculate the evolution of an equilibrium distribution whose functional form is not known \\emph{a priori}. Using a novel technique, applicable to any trace impurity, we have made this calculation not only possible, but particularly efficient. We demonstrate a microturbulence-induced departure from the local slowing-down distribution, an inversion of the energy distribution, and associated modifications to the alpha heating and pressure profiles in an ITER-like scenario.

  17. None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion

    DEFF Research Database (Denmark)

    He, Zhi-Yong; Brakebusch, Cord; Fässler, Reinhard;

    2003-01-01

    Antibody inhibition and alpha6beta1 ligand binding experiments indicate that the egg integrin alpha6beta1 functions as a receptor for sperm during gamete fusion; yet, eggs null for the alpha6 integrin exhibit normal fertilization. Alternative integrins may be involved in sperm-egg binding...... and fusion and could compensate for the absence of alpha6beta1. Various beta1 integrins and alphav integrins are present on mouse eggs. Some of these integrins are also reported to be receptors for ADAMs, which are expressed on sperm. Using alpha3 integrin null eggs, we found that the alpha3beta1 integrin...... was not essential for sperm-egg binding and fusion. Oocyte-specific, beta1 integrin conditional knockout mice allowed us to obtain mature eggs lacking all beta1 integrins. We found that the beta1 integrin null eggs were fully functional in fertilization both in vivo and in vitro. Furthermore, neither anti...

  18. On quality control of single-floor SBS roof waterproof craft with heat fusion method%热熔法单层 SBS 屋面防水工艺工程质量控制

    Institute of Scientific and Technical Information of China (English)

    赵基平

    2015-01-01

    结合工作经验,介绍了热熔法单层SBS屋面防水工艺原材料的控制要点,主要阐述了单层SBS屋面防水施工的质量控制措施,并对施工时适宜的气候条件进行了研究,以避免屋面防水质量问题的发生。%Combining with the work experience,the paper introduces the controlling measures for the single-floor SBS roof waterproof craft with heat fusion method,mainly illustrates the quality control measures for the construction,and researches the suitable climate conditions of the con-struction,so as to avoid the defects in the roof waterproof quality.

  19. Fusion Control Strategy Based on I-Fuzzy-Smith Algorithm for Complex Process with Large Lag%大时滞复杂过程中基于I-Fuzzy-Smith算法的融合控制策略

    Institute of Scientific and Technical Information of China (English)

    倪元敏

    2013-01-01

    Aimed at the puzzle to actualize the high quality control in complex process with large lag,the paper presented a sort of fusion control strategy based on the integration of integral, fuzzy and Smith estimator control algorithm.In the paper,it studied the cybernetics characteristic of complex process with large lag and its control puzzle,integrated itself superiority of integral, fuzzy and Smith estimator control,gave a sort of I-Fuzzy-Smith fusion control algorithm.It took a complex process of large inertia with large lag as an example,under the environment of Matlab, and made the detailed simulation experiment in contrast such as robustness etc.The system re-sponse curve demonstrated that the I-Fuzzy-Smith based control algorithm excels than others in dynamical and steady control quality and robustness.The research result shows that the pro-posed control algorithm is high in control precision,better in dynamical and steady control quality, and very strong robustness.%针对大时滞复杂过程难以实施高品质控制,提出了一种基于I-Fuzzy-Smith算法的融合控制策略。研究了大时滞复杂过程的控制论特性与控制难点,以及集成模糊、Smith预估和积分控制各自的优势,给出了将其融合的I-Fuzzy-Smith控制算法。以大惯性大时滞过程为例,基于Matlab仿真对融合控制进行了比较研究,系统响应验证了I-Fuzzy-Smith控制算法的动、静态控制品质和鲁棒性优于另外两种算法。研究结果表明:提出的融合策略控制精度高,系统动、静态控制品质好,表现出很强的鲁棒性。

  20. Advanced Fusion Reactors for Space Propulsion and Power Systems

    Science.gov (United States)

    Chapman, John J.

    2011-01-01

    In recent years the methodology proposed for conversion of light elements into energy via fusion has made steady progress. Scientific studies and engineering efforts in advanced fusion systems designs have introduced some new concepts with unique aspects including consideration of Aneutronic fuels. The plant parameters for harnessing aneutronic fusion appear more exigent than those required for the conventional fusion fuel cycle. However aneutronic fusion propulsion plants for Space deployment will ultimately offer the possibility of enhanced performance from nuclear gain as compared to existing ionic engines as well as providing a clean solution to Planetary Protection considerations and requirements. Proton triggered 11Boron fuel (p- 11B) will produce abundant ion kinetic energy for In-Space vectored thrust. Thus energetic alpha particles "exhaust" momentum can be used directly to produce high ISP thrust and also offer possibility of power conversion into electricity. p- 11B is an advanced fusion plant fuel with well understood reaction kinematics but will require some new conceptual thinking as to the most effective implementation.

  1. Design of lost alpha particle diagnostics for JET

    Energy Technology Data Exchange (ETDEWEB)

    Baeumel, S. [Max-Planck-Institut fuer Plasmaphysik EURATOM-Association, Wendelsteinstr.1, 17491 Greifswald (Germany)]. E-mail: baeumel@ipp.mpg.de; Werner, A. [Max-Planck-Institut fuer Plasmaphysik EURATOM-Association, Wendelsteinstr.1, 17491 Greifswald (Germany); Semler, R. [Max-Planck-Institut fuer Plasmaphysik EURATOM-Association, Wendelsteinstr.1, 17491 Greifswald (Germany); Mukherjee, S. [Max-Planck-Institut fuer Plasmaphysik EURATOM-Association, Wendelsteinstr.1, 17491 Greifswald (Germany); Darrow, D.S. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ (United States); Ellis, R. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, NJ (United States); Cecil, F.E. [Colorado School of Mines, 1500 Illinois St., Golden CO 80401 (United States); Pedrick, L. [EFDA-JET, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom); Altmann, H. [EFDA-JET, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom); Kiptily, V. [EFDA-JET, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom); Gafert, J. [EFDA-JET, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom)

    2005-11-15

    In a future magnetic fusion reactor alpha particles will be utlilized for plasma heating. In order to achieve a high efficiency of this process, the aim has to be a good confinement of alpha particles. Therefore, direct measurement of alpha particle losses is of particular interest. Two diagnostics are being prepared for the JET Tokamak that are targeting on exactly this subject: a scintillator probe and a set of Faraday cups . These systems are capable of measuring ICRH tail ions and charged fusion products. The scintillator probe aims to allow the detection of particles with a pitch angle between 30{sup o} and 86{sup o} (5% resolution) and a gyroradius between 20 and 140 mm (15% resolution). The Faraday cup array will detect the current of fast ions at multiple poloidal locations, with a dynamic range of 1 nA/cm{sup 2} to 100 {mu}A/cm{sup 2} at a temporal resolution of 1 ms. For 3.5 MeV {alpha}-particles the energy binning of the foil detector will be 15-50% of the full energy depending on the geometry of the individual collector. The experience in operating both diagnostics in a high temperature and high radiation environment will give valuable information in preparation for the design of similar diagnostics for future fusion devices. This paper covers the design and engineering of both diagnostics together with their envisaged performance.

  2. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

    Science.gov (United States)

    Pandolfi, P P; Alcalay, M; Fagioli, M; Zangrilli, D; Mencarelli, A; Diverio, D; Biondi, A; Lo Coco, F; Rambaldi, A; Grignani, F

    1992-01-01

    The acute promyelocytic leukaemia (APL) 15;17 translocation generates a PML/RAR alpha chimeric gene which is transcribed as a fusion PML/RAR alpha mRNA. Molecular studies on a large series of APLs revealed great heterogeneity of the PML/RAR alpha transcripts due to: (i) variable breaking of chromosome 15 within three PML breakpoint cluster regions (bcr1, bcr2 and bcr3), (ii) alternative splicings of the PML portion and (iii) alternative usage of two RAR alpha polyadenylation sites. Nucleotide sequence analysis predicted two types of proteins: multiple PML/RAR alpha and aberrant PML. The PML/RAR alpha proteins varied among bcr1, 2 and 3 APL cases and within single cases. The fusion proteins contained variable portions of the PML N terminus joined to the B-F RAR alpha domains; the only PML region retained was the putative DNA binding domain. The aberrant PML proteins lacked the C terminus, which had been replaced by from two to ten amino acid residues from the RAR alpha sequence. Multiple PML/RAR alpha isoforms and aberrant PML proteins were found to coexist in all APLs. These findings indicate that two potential oncogenic proteins are generated by the t(15;17) and suggest that the PML activation pathway is altered in APLs. Images PMID:1314166

  3. Pain and functional improvement effects of methylene blue injection on the soft tissue around fusion site after traumatic thoracolumbar fixation: A double-blind, randomized placebo-controlled study.

    Science.gov (United States)

    Farrokhi, Majid Reza; Yazdanpanah, Hamed; Gholami, Mehrnaz; Farrokhi, Farnaz; Mesbahi, Amir Reza

    2016-11-01

    Fractures of the thoracolumbar spine can cause pain, long-term reductions in quality of life (QOL), and neural deficits. The aim of this study was to investigate the effects of methylene blue (MB) on preventing postoperative pain and improving QOL in patients with throracolumbar fractures undergoing posterior pedicle screw fixation. Fifty patients underwent standard posterior pedicular screw fixation for stabilization of the thoracolumbar fractures: 25 received 1ml of MB solution at a concentration of 0.5% and 25 received normal saline on the soft tissue around fusion site. Primary outcomes were the control of pain, evaluated at 48h, 2 and 6 months after surgery with the use of a visual analog scale (VAS), and the improvement of QOL, assessed 2 and 6 months postoperatively by means of Oswestry Disability Index (ODI) questionnaire. The mean VAS scores for pain were significantly lower in the MB group compared with the control group at 2 months (1.30±0.45 vs. 2.60±1.19, P<0.001) and 6 months (1.17±0.37 vs. 1.60±0.87; P=0.028) after treatment. At 2 months after the surgery, the mean ODI score was significantly lower in the MB-treated patients than the control group (20.4±10.92 vs. 34.8±15.11; P=0.001). The ODI score in the MB-treated patients was better than the control group at 6 months after the surgery (12.2±11.66 vs. 20.8±11.14; P=0.016). A single dose of MB on the soft tissue around fusion site shows promising results in terms of safety, reduction of postoperative pain, and functional results when compared with placebo 6 months after surgery. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. 最大子图序列平滑的飞控图层无缝融合技术%Seamless Fusion Technology of Flight Control Visual Layers Based on Maximum Sub-graph Sequence Smooth Method

    Institute of Scientific and Technical Information of China (English)

    姜军; 卓嘎; 王朝霞; 陈延利

    2014-01-01

    Seamless integration of multi-layer technology is the most difficult thing for three-dimensional visual simulation, the seamless integration points requires for fusion with multiple visual layers effectively smooth, reaching the depth of the layer embedded purposes. In the traditional three-dimensional visual layer fusion method, the fuzzy RGB color pixel inter-polation function method is used,the high-order odd curve fitting is taken as the objective function to deploy and achieve the edge of the center pixel fusion, this method has good effect for a layer of smaller differences, but when the layers are quite different, the results is poor. A three-dimensional flight control visual layers seamless fusion technology based on maximum sub-graph sequence smooth method is proposed, the maximum sub-graph sequence of layers is deducted, the fu-sion sequences is transferred into maximum sub-graph smoothers, the flash wave of door forecast is used in different layers, the smoothing correction method is used for a sequence of smooth curves deviate from the point of correction, and the seam-less smooth result is output. The effective three-dimensional visual simulation layer of flight is taken as experiment, and the results show that with the proposed method, the layer fusion result is better than traditional methods, it has good applica-tion value in the integration layer for the three-dimensional visual simulation.%多图层无缝融合技术是三维视景仿真中的难点,无缝融合中要求对多个视景图层的融合点进行有效平滑,达到图层深度嵌入的目的。传统的三维飞控图层无缝融合方法采用基于RGB颜色模糊调配与像素点函数内插方法实现,以高阶奇次曲线拟合为目标函数,内插形成图层融合过渡带,此方法对于图层差异较小的融合有较好效果,当图层差异较大时,效果不佳。提出一种基于最大子图序列平滑的三维飞控图层无缝融合技术,对不同

  5. Collagen alpha5 and alpha2(IV) chain coexpression: analysis of skin biopsies of Alport patients.

    Science.gov (United States)

    Patey-Mariaud de Serre, N; Garfa, M; Bessiéres, B; Noël, L H; Knebelmann, B

    2007-08-01

    Alport syndrome is a collagen type IV disease caused by mutations in the COL4A5 gene with the X-linked form being most prevalent. The resultant alpha5(IV) collagen chain is a component of the glomerular and skin basement membranes (SBMs). Immunofluorescent determination of the alpha5(IV) chain in skin biopsies is the procedure of choice to identify patients. In 30% of patients, however, the mutant protein is still found in the SBM resulting in a normal staining pattern. In order to minimize or eliminate false results, we compared the distribution of the alpha2(IV) chain (another SBM component) and the alpha5(IV) chain by standard double label immunofluorescence (IF) and by confocal laser scanning microscopy. The study was performed on 55 skin biopsies of patients suspected of Alports and five normal control specimens. In normal skin, IF showed the classical linear pattern for both collagens along the basement membrane. Additionally, decreased alpha5(IV) was found in the bottom of the dermal papillary basement membrane. Confocal analysis confirmed the results and show alpha5(IV) focal interruptions. In suspected patients, both techniques showed the same rate of abnormal alpha5(IV) expression: segmental in women and absent in men. Our results show a physiological variation of alpha5(IV) location with focal interruptions and decreased expression in the bottom of the dermal basement membrane. Comparison of alpha5(IV) with alpha2(IV) expression is simple and eliminates technical artifacts.

  6. Fusion Reactor Materials

    Energy Technology Data Exchange (ETDEWEB)

    Decreton, M

    2002-04-01

    The objective of SCK-CEN's programme on fusion reactor materials is to contribute to the knowledge on the radiation-induced behaviour of fusion reactor materials and components as well as to help the international community in building the scientific and technical basis needed for the construction of the future reactor. Ongoing projects include: the study of the mechanical and chemical (corrosion) behaviour of structural materials under neutron irradiation and water coolant environment; the investigation of the characteristics of irradiated first wall material such as beryllium; investigations on the management of materials resulting from the dismantling of fusion reactors including waste disposal. Progress and achievements in these areas in 2001 are discussed.

  7. Multibiometrics Belief Fusion

    CERN Document Server

    Kisku, Dakshina Ranjan; Gupta, Phalguni

    2010-01-01

    This paper proposes a multimodal biometric system through Gaussian Mixture Model (GMM) for face and ear biometrics with belief fusion of the estimated scores characterized by Gabor responses and the proposed fusion is accomplished by Dempster-Shafer (DS) decision theory. Face and ear images are convolved with Gabor wavelet filters to extracts spatially enhanced Gabor facial features and Gabor ear features. Further, GMM is applied to the high-dimensional Gabor face and Gabor ear responses separately for quantitive measurements. Expectation Maximization (EM) algorithm is used to estimate density parameters in GMM. This produces two sets of feature vectors which are then fused using Dempster-Shafer theory. Experiments are conducted on multimodal database containing face and ear images of 400 individuals. It is found that use of Gabor wavelet filters along with GMM and DS theory can provide robust and efficient multimodal fusion strategy.

  8. Fusion research at ORNL

    Energy Technology Data Exchange (ETDEWEB)

    1982-03-01

    The ORNL Fusion Program includes the experimental and theoretical study of two different classes of magnetic confinement schemes - systems with helical magnetic fields, such as the tokamak and stellarator, and the ELMO Bumpy Torus (EBT) class of toroidally linked mirror systems; the development of technologies, including superconducting magnets, neutral atomic beam and radio frequency (rf) heating systems, fueling systems, materials, and diagnostics; the development of databases for atomic physics and radiation effects; the assessment of the environmental impact of magnetic fusion; and the design of advanced demonstration fusion devices. The program involves wide collaboration, both within ORNL and with other institutions. The elements of this program are shown. This document illustrates the program's scope; and aims by reviewing recent progress.

  9. Medical Image Fusion

    Directory of Open Access Journals (Sweden)

    Mitra Rafizadeh

    2007-08-01

    Full Text Available Technological advances in medical imaging in the past two decades have enable radiologists to create images of the human body with unprecedented resolution. MRI, PET,... imaging devices can quickly acquire 3D images. Image fusion establishes an anatomical correlation between corresponding images derived from different examination. This fusion is applied either to combine images of different modalities (CT, MRI or single modality (PET-PET."nImage fusion is performed in two steps:"n1 Registration: spatial modification (eg. translation of model image relative to reference image in order to arrive at an ideal matching of both images. Registration methods are feature-based and intensity-based approaches."n2 Visualization: the goal of it is to depict the spatial relationship between the model image and refer-ence image. We can point out its clinical application in nuclear medicine (PET/CT.

  10. Sensor Data Fusion

    DEFF Research Database (Denmark)

    Plascencia, Alfredo; Stepán, Petr

    2006-01-01

    The main contribution of this paper is to present a sensor fusion approach to scene environment mapping as part of a Sensor Data Fusion (SDF) architecture. This approach involves combined sonar array with stereo vision readings.  Sonar readings are interpreted using probability density functions...... to the occupied and empty regions. Scale Invariant Feature Transform (SIFT) feature descriptors are interpreted using gaussian probabilistic error models. The use of occupancy grids is proposed for representing the sensor readings. The Bayesian estimation approach is applied to update the sonar array......  and the SIFT descriptors' uncertainty grids. The sensor fusion yields a significant reduction in the uncertainty of the occupancy grid compared to the individual sensor readings....

  11. What controls open-pore and residual currents in the first sensing zone of alpha-hemolysin nanopore? Combined experimental and theoretical study

    Science.gov (United States)

    de Biase, Pablo M.; Ervin, Eric N.; Pal, Prithwish; Samoylova, Olga; Markosyan, Suren; Keehan, Michael G.; Barrall, Geoffrey A.; Noskov, Sergei Yu.

    2016-06-01

    The electrophoretic transport of single-stranded DNA through biological nanopores such as alpha-hemolysin (αHL) is a promising and cost-effective technology with the potential to revolutionize genomics. The rational design of pores with the controlled polymer translocation rates and high contrast between different nucleotides could improve significantly nanopore sequencing applications. Here, we apply a combination of theoretical and experimental methods in an attempt to elucidate several selective modifications in the pore which were proposed to be central for the effective discrimination between purines and pyrimidines. Our nanopore test set includes the wild type αHL and six mutants (E111N/M113X/K147N) in which the cross-section and chemical functionality of the first constriction zone of the pore are modified. Electrophysiological recordings were combined with all-atom Molecular Dynamics simulations (MD) and a recently developed Brownian Dynamics (BROMOC) protocol to investigate residual ion currents and pore-DNA interactions for two homo-polymers e.g. poly(dA)40 or poly(dC)40 blocking the pore. The calculated residual currents and contrast in the poly(dA)40/poly(dC)40 blocked pore are in qualitative agreement with the experimental recordings. We showed that a simple structural metric allows rationalization of key elements in the emergent contrast between purines and pyrimidines in the modified αHL mutants. The shape of the pore and its capacity for hydrogen bonding to a translocated polynucleotide are two essential parameters for contrast optimization. To further probe the impact of these two factors in the ssDNA sensing, we eliminated the effect of the primary constriction using serine substitutions (i.e. E111S/M113S/T145S/K147S) and increased the hydrophobic volume of the central residue in the secondary constriction (L135I). This pore modification sharply increased the contrast between Adenine (A) and Cytosine (C).The electrophoretic transport of single

  12. Alpha Shapes and Proteins

    DEFF Research Database (Denmark)

    Winter, Pawel; Sterner, Henrik; Sterner, Peter

    2009-01-01

    We provide a unified description of (weighted) alpha shapes, beta shapes and the corresponding simplicialcomplexes. We discuss their applicability to various protein-related problems. We also discuss filtrations of alpha shapes and touch upon related persistence issues.We claim that the full...... potential of alpha-shapes and related geometrical constructs in protein-related problems yet remains to be realized and verified. We suggest parallel algorithms for (weighted) alpha shapes, and we argue that future use of filtrations and kinetic variants for larger proteins will need such implementation....

  13. Interpreting EEG alpha activity.

    Science.gov (United States)

    Bazanova, O M; Vernon, D

    2014-07-01

    Exploring EEG alpha oscillations has generated considerable interest, in particular with regards to the role they play in cognitive, psychomotor, psycho-emotional and physiological aspects of human life. However, there is no clearly agreed upon definition of what constitutes 'alpha activity' or which of the many indices should be used to characterize it. To address these issues this review attempts to delineate EEG alpha-activity, its physical, molecular and morphological nature, and examine the following indices: (1) the individual alpha peak frequency; (2) activation magnitude, as measured by alpha amplitude suppression across the individual alpha bandwidth in response to eyes opening, and (3) alpha "auto-rhythmicity" indices: which include intra-spindle amplitude variability, spindle length and steepness. Throughout, the article offers a number of suggestions regarding the mechanism(s) of alpha activity related to inter and intra-individual variability. In addition, it provides some insights into the various psychophysiological indices of alpha activity and highlights their role in optimal functioning and behavior.

  14. Atomic data for fusion

    Energy Technology Data Exchange (ETDEWEB)

    Hunter, H.T.; Kirkpatrick, M.I.; Alvarez, I.; Cisneros, C.; Phaneuf, R.A. (eds.); Barnett, C.F.

    1990-07-01

    This report provides a handbook of recommended cross-section and rate-coefficient data for inelastic collisions between hydrogen, helium and lithium atoms, molecules and ions, and encompasses more than 400 different reactions of primary interest in fusion research. Published experimental and theoretical data have been collected and evaluated, and the recommended data are presented in tabular, graphical and parametrized form. Processes include excitation and spectral line emission, charge exchange, ionization, stripping, dissociation and particle interchange reactions. The range of collision energies is appropriate to applications in fusion-energy research.

  15. Fusion Welding Research.

    Science.gov (United States)

    2014-09-26

    RD-AlSO 253 FUSION WELDING RESEARCH(U) MASSACHUSETTS INST OF TECH L/I CAMBRIDGE DEPT OF MATERIALS SCIENCE AND ENGINEERING T W EAGAR ET AL. 30 RPR 85...NUMBER 12. GOV’ ACCESSION NO. 3. RECICIE-S CATALOG NUMBER 4. T TL V nd Subtitle) S. P OFRPR PERIOD COVERED 5t h A~nnual Technical Report Fusion Welding ...research S on welding processes. Studies include metal vapors in the arc, development of a high speed infrared temperature monitor, digital signal

  16. Fusion Reactor Materials

    Energy Technology Data Exchange (ETDEWEB)

    Decreton, M

    2000-07-01

    SCK-CEN's research and development programme on fusion reactor materials includes: (1) the study of the mechanical behaviour of structural materials under neutron irradiation (including steels, inconel, molybdenum, chromium); (2) the determination and modelling of the characteristics of irradiated first wall materials such as beryllium; (3) the detection of abrupt electrical degradation of insulating ceramics under high temperature and neutron irradiation; (4) the study of the dismantling and waste disposal strategy for fusion reactors.; (5) a feasibility study for the testing of blanket modules under neutron radiation. Main achievements in these topical areas in the year 1999 are summarised.

  17. Sensor fusion method for machine performance enhancement

    Energy Technology Data Exchange (ETDEWEB)

    Mou, J.I. [Arizona State Univ., Tempe, AZ (United States); King, C.; Hillaire, R. [Sandia National Labs., Livermore, CA (United States). Integrated Manufacturing Systems Center; Jones, S.; Furness, R. [Ford Motor Co., Dearborn, MI (United States)

    1998-03-01

    A sensor fusion methodology was developed to uniquely integrate pre-process, process-intermittent, and post-process measurement and analysis technology to cost-effectively enhance the accuracy and capability of computer-controlled manufacturing equipment. Empirical models and computational algorithms were also developed to model, assess, and then enhance the machine performance.

  18. Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size.

    Science.gov (United States)

    Kato, Kazunobu; Martinez, Constantino; Russell, Susan; Nurden, Paquita; Nurden, Alan; Fiering, Steven; Ware, Jerry

    2004-10-15

    Here we report the characterization of a mouse model of the Bernard-Soulier syndrome generated by a targeted disruption of the gene encoding the glycoprotein (GP) Ibbeta subunit of the GP Ib-IX complex. Similar to a Bernard-Soulier model generated by disruption of the mouse GP Ibalpha subunit, GP Ibbeta(Null) mice display macrothrombocytopenia and a severe bleeding phenotype. When examined by transmission electron microscopy, the large platelets produced by a GP Ibbeta(Null) genotype revealed alpha-granules with increased size as compared with the alpha-granules from control mouse platelets. Data are presented linking the overexpression of a septin protein, SEPT5, to the presence of larger alpha-granules in the GP Ibbeta(Null) platelet. The SEPT5 gene resides approximately 250 nucleotides 5' to the GP Ibbeta gene and has been associated with modulating exocytosis from neurons and platelets as part of a presynaptic protein complex. Fusion mRNA transcripts present in megakaryocytes can contain both the SEPT5 and GP Ibbeta coding sequences as a result in an imperfect polyadenylation signal within the 3' end of both the human and mouse SEPT5 genes. We observed a 2- to 3-fold increase in SEPT5 protein levels in platelets from GP Ibbeta(Null) mice. These results implicate SEPT5 levels in the maintenance of normal alpha-granule size and may explain the variant granules associated with human GP Ibbeta mutations and the Bernard-Soulier syndrome.

  19. Temperature derivatives for fusion reactivity of D-D and D-T

    Energy Technology Data Exchange (ETDEWEB)

    Langenbrunner, James R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Makaruk, Hanna Ewa [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-11-29

    Deuterium-tritium (D-T) and deuterium-deuterium (D-D) fusion reaction rates are observable using leakage gamma flux. A direct measurement of γ-rays with equipment that exhibits fast temporal response could be used to infer temperature, if the detector signal is amenable for taking the logarithmic time-derivative, alpha. We consider the temperature dependence for fusion cross section reactivity.

  20. Fusion Reactor and Break-Even Experiment Based on Stabilized Liner Compression of Plasma

    Science.gov (United States)

    Turchi, Peter; Frese, Sherry; Frese, Michael

    2016-10-01

    An optimum regime, known as magnetized-target or magneto-inertial fusion (MTF/MIF), requires magnetic fields at megagauss levels, which are attainable by use of dynamic conductors called liners. The stabilized liner compressor (SLC) provides the basis for controlled implosion and re-capture of the liner for reversible energy exchange between liner kinetic energy and the internal energy of a magnetized-plasma target. This exchange requires rotational stabilization of Rayleigh-Taylor modes on the inner surface of the liner and pneumatically driven free-pistons that eliminate such modes at the outer surface. We discuss the implications of the SLC approach for the power reactor, a breakeven experiment, and intermediate experiments to develop the plasma target. Features include the importance of pneumatic drive and the liner-blanket for economic feasibility of MTF/MIF. Supported by ARPA-E ALPHA Program.

  1. Fusion plasma physics during half a century

    Energy Technology Data Exchange (ETDEWEB)

    Lehnert, Bo

    1999-08-01

    A review is given on the potentialities of fusion energy with respect to energy production and related environmental problems, the various approaches to controlled thermonuclear fusion, the main problem areas of research, the historical development, the present state of investigations, and future perspectives. This article also presents a personal memorandum of the author. Thereby special reference will be given to part of the research conducted at the Royal Institute of Technology in Stockholm, merely to identify its place within the general historical development. Considerable progress has been made in fusion research during the last decades. In large tokamak experiments temperatures above the ignition limit of about 10{sup 8} K have been reached under break-even conditions where the fusion power generation is comparable to the energy loss. A power producing fusion reactor could in principle be realized already today, but it would not become technically and economically efficient. The future international research programme has therefore to be conducted along broad lines, with necessary ingredients of basis research and new ideas, and also within lines of magnetic confinement being alternative to that of tokamaks.

  2. On the path to fusion energy

    Science.gov (United States)

    Tabak, M.

    2016-10-01

    There is a need to develop alternate energy sources in the coming century because fossil fuels will become depleted and their use may lead to global climate change. Inertial fusion can become such an energy source, but significant progress must be made before its promise is realized. The high-density approach to inertial fusion suggested by Nuckolls et al. leads reaction chambers compatible with civilian power production. Methods to achieve the good control of hydrodynamic stability and implosion symmetry required to achieve these high fuel densities will be discussed. Fast Ignition, a technique that achieves fusion ignition by igniting fusion fuel after it is assembled, will be described along with its gain curves. Fusion costs of energy for conventional hotspot ignition will be compared with those of Fast Ignition and their capital costs compared with advanced fission plants. Finally, techniques that may improve possible Fast Ignition gains by an order of magnitude and reduce driver scales by an order of magnitude below conventional ignition requirements are described.

  3. Variables Affecting Fusion Rates in the Rat Posterolateral Spinal Fusion Model with Autogenic/Allogenic Bone Grafts: A Meta-analysis.

    Science.gov (United States)

    Ishida, Wataru; Elder, Benjamin D; Holmes, Christina; Lo, Sheng-Fu L; Witham, Timothy F

    2016-11-01

    The rat posterolateral spinal fusion model with autogenic/allogenic bone graft (rat PFABG) has been increasingly utilized as an experimental model to assess the efficacy of novel fusion treatments. The objective of this study was to investigate the reliability of the rat PFABG model and examine the effects of different variables on spinal fusion. A web-based literature search from January, 1970 to September, 2015, yielded 26 studies, which included 40 rat PFABG control groups and 449 rats. Data regarding age, weight, sex, and strain of rats, graft volume, graft type, decorticated levels, surgical approach, institution, the number of control rats, fusion rate, methods of fusion assessment, and timing of fusion assessment were collected and analyzed. The primary outcome variable of interest was fusion rate, as evaluated by manual palpation. Fusion rates varied widely, from 0 to 96%. The calculated overall fusion rate was 46.1% with an I (2) value of 62.4, which indicated moderate heterogeneity. Weight >300 g, age >14 weeks, male rat, Sprague-Dawley strain, and autogenic coccyx grafts increased fusion rates with statistical significance. Additionally, an assessment time-point ≥8 weeks had a trend towards statistical significance (p = 0.070). Multi-regression analysis demonstrated that timing of assessment and age as continuous variables, as well as sex as a categorical variable, can predict the fusion rate with R (2) = 0.82. In an inter-institution reliability analysis, the pooled overall fusion rate was 50.0% [44.8, 55.3%], with statistically significant differences among fusion outcomes at different institutions (p fusion outcomes, the reliability of the rat PFABG model was relatively limited. However, selection of adequate variables can optimize its use as a control group in studies evaluating the efficacy of novel fusion therapies.

  4. Calculating fusion neutron energy spectra from arbitrary reactant distributions

    Science.gov (United States)

    Eriksson, J.; Conroy, S.; Andersson Sundén, E.; Hellesen, C.

    2016-02-01

    The Directional Relativistic Spectrum Simulator (DRESS) code can perform Monte-Carlo calculations of reaction product spectra from arbitrary reactant distributions, using fully relativistic kinematics. The code is set up to calculate energy spectra from neutrons and alpha particles produced in the D(d, n)3He and T(d, n)4He fusion reactions, but any two-body reaction can be simulated by including the corresponding cross section. The code has been thoroughly tested. The kinematics calculations have been benchmarked against the kinematics module of the ROOT Data Analysis Framework. Calculated neutron energy spectra have been validated against tabulated fusion reactivities and against an exact analytical expression for the thermonuclear fusion neutron spectrum, with good agreement. The DRESS code will be used as the core of a detailed synthetic diagnostic framework for neutron measurements at the JET and MAST tokamaks.

  5. Mid- to Long-Term Outcomes of Cervical Disc Arthroplasty versus Anterior Cervical Discectomy and Fusion for Treatment of Symptomatic Cervical Disc Disease: A Systematic Review and Meta-Analysis of Eight Prospective Randomized Controlled Trials.

    Directory of Open Access Journals (Sweden)

    Yan Hu

    Full Text Available This study aimed to investigate the mid- to long-term outcomes of cervical disc arthroplasty (CDA versus anterior cervical discectomy and fusion (ACDF for the treatment of 1-level or 2-level symptomatic cervical disc disease.Medline, Embase, and the Cochrane Central Register of Controlled Trials databases were searched to identify relevant randomized controlled trials that reported mid- to long-term outcomes (at least 48 months of CDA versus ACDF. All data were analyzed by Review Manager 5.3 software. The relative risk (RR and 95% confidence intervals (CIs were calculated for dichotomous variables. The weighted mean difference (WMD and 95%CIs were calculated for continuous variables. A random effect model was used for heterogeneous data; otherwise, a fixed effect model was used.Eight prospective randomized controlled trials (RCTs were retrieved in this meta-analysis, including 1317 and 1051 patients in CDA and ACDF groups, respectively. Patients after an ACDF had a significantly lower rate of follow-up than that after CDA. Pooled analysis showed patients in CDA group achieved significantly higher rates of overall success, Neck Disability Index (NDI success, neurological success and significantly lower rates of implant/surgery-related serious adverse events and secondary procedure compared with that in ACDF group. The long-term functional outcomes (NDI, Visual Analog Scale (VAS neck and arm pain scores, the Short Form 36 Health Survey physical component score (SF-36 PCS, patient satisfaction and recommendation, and the incidence of superior adjacent segment degeneration also favored patients in CDA group with statistical difference. Regarding inferior adjacent segment degeneration, patients in CDA group had a lower rate without statistical significance.This meta-analysis showed that cervical disc arthroplasty was superior over anterior discectomy and fusion for the treatment of symptomatic cervical disc disease in terms of overall success, NDI

  6. Exploring Forensic Implications of the Fusion Drive

    Directory of Open Access Journals (Sweden)

    Shruti Gupta

    2014-09-01

    Full Text Available This paper explores the forensic implications of Apple's Fusion Drive. The Fusion Drive is an example of auto-tiered storage. It uses a combination of a flash drive and a magnetic drive. Data is moved between the drives automatically to maximize system performance. This is different from traditional caches because data is moved and not simply copied. The research included understanding the drive structure, populating the drive, and then accessing data in a controlled setting to observe data migration strategies. It was observed that all the data is first written to the flash drive with 4 GB of free space always maintained. If data on the magnetic drive is frequently accessed, it is promoted to the flash drive while demoting other information. Data is moved at a block-level and not a file-level. The Fusion Drive didn't alter the timestamps of files with data migration.

  7. Controlled synthesis of alpha-Fe2O3 nanorods and its size-dependent optical absorption, electrochemical, and magnetic properties.

    Science.gov (United States)

    Zeng, Suyuan; Tang, Kaibin; Li, Tanwei

    2007-08-15

    Uniform alpha-Fe(2)O(3) nanorods with diameter of about 30 nm and length up to 500 nm were synthesized by a template-free hydrothermal method and a following calcination of the intermediate product in the air at 500 degrees C for 2 h. By carefully tuning the concentration of the reactants, a series of alpha-Fe(2)O(3) nanorods with gradient in aspect ratios can be obtained. The effect of the solvent was also evaluated. Based on the experimental facts, the formation mechanism of this one-dimensional structure was proposed. The size-dependent properties of the as-obtained alpha-Fe(2)O(3) nanorods were investigated. The optical absorption properties of the samples showed that the band gaps of the samples decreased in the sequence in which the size increased. The electrochemical performance of the samples showed that the discharge capacity decreased as the size of the sample increased, which may result from the high surface area and small size. The magnetic hysteresis measurements taken at 5 K showed that the coercivities of the samples were related to the aspect ratios of the samples, which may result from the larger shape anisotropy. However, the temperature-dependent field cooling magnetization showed that there was no Morin transition in the as-prepared samples, which may result from the surface effect.

  8. Fusion engineering device design description

    Energy Technology Data Exchange (ETDEWEB)

    Flanagan, C.A.; Steiner, D.; Smith, G.E.

    1981-12-01

    The US Magnetic Fusion Engineering Act of 1980 calls for the operation of a Fusion Engineering Device (FED) by 1990. It is the intent of the Act that the FED, in combination with other testing facilities, will establish the engineering feasibility of magnetic fusion energy. During 1981, the Fusion Engineering Design Center (FEDC), under the guidance of a Technical Management Board (TMB), developed a baseline design for the FED. This design is summarized herein.

  9. Fusion Engineering Device design description

    Energy Technology Data Exchange (ETDEWEB)

    Flanagan, C.A.; Steiner, D.; Smith, G.E.

    1981-12-01

    The US Magnetic Fusion Engineering Act of 1980 calls for the operation of a Fusion Engineering Device (FED) by 1990. It is the intent of the Act that the FED, in combination with other testing facilities, will establish the engineering feasibility of magnetic fusion energy. During 1981, the Fusion Engineering Design Center (FEDC), under the guidance of a Technical Management Board (TMB), developed a baseline design for the FED. This design is summarized herein.

  10. Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report.

    Science.gov (United States)

    Trosclair, Christopher; Pollen, Maressa; Capraro, Gerald; Cotelingam, James; Shackelford, Rodney E

    2014-05-01

    Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML) subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype.

  11. Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report

    Directory of Open Access Journals (Sweden)

    Christopher Trosclair

    2014-06-01

    Full Text Available Acute promyelocytic leukemia (APL is characterized by a t(15;17 which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype.

  12. Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion.

    Science.gov (United States)

    Mullock, B M; Smith, C W; Ihrke, G; Bright, N A; Lindsay, M; Parkinson, E J; Brooks, D A; Parton, R G; James, D E; Luzio, J P; Piper, R C

    2000-09-01

    Protein traffic from the cell surface or the trans-Golgi network reaches the lysosome via a series of endosomal compartments. One of the last steps in the endocytic pathway is the fusion of late endosomes with lysosomes. This process has been reconstituted in vitro and has been shown to require NSF, alpha and gamma SNAP, and a Rab GTPase based on inhibition by Rab GDI. In Saccharomyces cerevisiae, fusion events to the lysosome-like vacuole are mediated by the syntaxin protein Vam3p, which is localized to the vacuolar membrane. In an effort to identify the molecular machinery that controls fusion events to the lysosome, we searched for mammalian homologues of Vam3p. One such candidate is syntaxin 7. Here we show that syntaxin 7 is concentrated in late endosomes and lysosomes. Coimmunoprecipitation experiments show that syntaxin 7 is associated with the endosomal v-SNARE Vamp 8, which partially colocalizes with syntaxin 7. Importantly, we show that syntaxin 7 is specifically required for the fusion of late endosomes with lysosomes in vitro, resulting in a hybrid organelle. Together, these data identify a SNARE complex that functions in the late endocytic system of animal cells.

  13. CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma

    DEFF Research Database (Denmark)

    Engelholm, Lars H; Riaz, Anjum; Serra, Denise

    2017-01-01

    ) to the protein kinase cAMP-activated catalytic subunit alpha gene (PRKACA) has been repeatedly identified in patients with FL-HCC. However, the DNAJB1-PRKACA gene fusion has not been shown to induce liver tumorigenesis. We used the CRISPR/Cas9 technique to delete in mice the syntenic region on chromosome 8...... to create a Dnajb1-Prkaca fusion and monitored the mice for liver tumor development. METHODS: We delivered CRISPR/Cas9 vectors designed to juxtapose exon 1 of Dnajb1 with exon 2 of Prkaca to create the Dnajb1-Prkaca gene fusion associated with FL-HCC, or control Cas9 vector, via hydrodynamic tail vein......, as observed in human FL-HCC. CONCLUSIONS: Using CRISPR/Cas9 technology, we found generation of the Dnajb1-Prkaca fusion gene in wild-type mice to be sufficient to initiate formation of tumors that have many features of human FL-HCC. Strategies to block DNAJB1-PRKACA might be developed as therapeutics...

  14. Measurement of limiter heating due to fusion product losses during high fusion power deuterium-tritium operation of TFTR

    Energy Technology Data Exchange (ETDEWEB)

    Janos, A.; Owens, D.K.; Darrow, D.; Redi, M.; Zarnstorff, M.; Zweben, S.

    1995-03-01

    Preliminary analysis has been completed on measurements of limiter heating during high fusion power deuterium-tritium (D-T) operation of TFTR, in an attempt to identify heating from alpha particle losses. Recent operation of TFTR with a 50-50 mix of D-T has resulted in fusion power output ({approx} 6.2 MW) orders of magnitude above what was previously achieved on TFTR. A significantly larger absolute number of particles and energy from fusion products compared to D-D operation is expected to be lost to the limiters. Measurements were made in the vicinity of the midplane ({plus_minus} 30{degree}) with thermocouples mounted on the tiles of an outboard limiter. Comparisons were made -between discharges which were similar except for the mix of deuterium and tritium beam sources. Power and energy estimates of predicted alpha losses were as high as 0.13 MW and 64 kJ. Depending on what portion of the limiters absorbed this energy, temperature rises of up to 42 {degrees}C could be expected, corresponding to a heat load of 0.69 MJ/m{sup 2} over a 0.5 sec period, or a power load of 1.4 MW/m{sup 2}. There was a measurable increase in the limiter tile temperature as the fusion power yield increased with a more reactive mixture of D and T at constant beam power during high power D-T operation. Analysis of the data is being conducted to see if the alpha heating component can be extracted. Measured temperature increases were no greater than 1 {degree}C, indicating that there was probably neither an unexpectedly large fraction of lost particles nor unexpected localization of the losses. Limits on the stochastic ripple loss contribution from alphas can be deduced.

  15. International fusion og spaltning

    DEFF Research Database (Denmark)

    Hansen, Lone L.

    Bogen analyserer de nye muligheder fra 2007 i europæisk ret med hensyn til fusion eller spaltning mellem aktieselskaber og anpartsselskaber med hjemsted i forskellige europæiske lande. Bogen gennemgår de nye muligheder for strukturændringer, der herved er opstået mulighed for, og den sætter fokus...

  16. Fusion reactor materials

    Energy Technology Data Exchange (ETDEWEB)

    none,

    1989-01-01

    This paper discuses the following topics on fusion reactor materials: irradiation, facilities, test matrices, and experimental methods; dosimetry, damage parameters, and activation calculations; materials engineering and design requirements; fundamental mechanical behavior; radiation effects; development of structural alloys; solid breeding materials; and ceramics.

  17. International fusion og spaltning

    DEFF Research Database (Denmark)

    Hansen, Lone L.

    Bogen analyserer de nye muligheder fra 2007 i europæisk ret med hensyn til fusion eller spaltning mellem aktieselskaber og anpartsselskaber med hjemsted i forskellige europæiske lande. Bogen gennemgår de nye muligheder for strukturændringer, der herved er opstået mulighed for, og den sætter fokus...

  18. Synergetic Multisensor Fusion

    Science.gov (United States)

    1990-11-30

    technology have led to increased interest in using DEMs for navigation and other applications. In particular, DEMs are attractive for use in aircraft...Multisensor Fusion for Computer Vision [67]. 30 6. POSI!IONAL zSTIM&TION TECEnIQUzs FOR AN OUTDOOR MOBLE ROBOT The autonomous navigation of mobile robots is

  19. Iterative guided image fusion

    Directory of Open Access Journals (Sweden)

    Alexander Toet

    2016-08-01

    Full Text Available We propose a multi-scale image fusion scheme based on guided filtering. Guided filtering can effectively reduce noise while preserving detail boundaries. When applied in an iterative mode, guided filtering selectively eliminates small scale details while restoring larger scale edges. The proposed multi-scale image fusion scheme achieves spatial consistency by using guided filtering both at the decomposition and at the recombination stage of the multi-scale fusion process. First, size-selective iterative guided filtering is applied to decompose the source images into approximation and residual layers at multiple spatial scales. Then, frequency-tuned filtering is used to compute saliency maps at successive spatial scales. Next, at each spatial scale binary weighting maps are obtained as the pixelwise maximum of corresponding source saliency maps. Guided filtering of the binary weighting maps with their corresponding source images as guidance images serves to reduce noise and to restore spatial consistency. The final fused image is obtained as the weighted recombination of the individual residual layers and the mean of the approximation layers at the coarsest spatial scale. Application to multiband visual (intensified and thermal infrared imagery demonstrates that the proposed method obtains state-of-the-art performance for the fusion of multispectral nightvision images. The method has a simple implementation and is computationally efficient.

  20. Muon catalyzed fusion

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, K. [Advanced Meson Science Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Nagamine, K. [Muon Science Laboratory, IMSS-KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Matsuzaki, T. [Advanced Meson Science Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Kawamura, N. [Muon Science Laboratory, IMSS-KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)

    2005-12-15

    The latest progress of muon catalyzed fusion study at the RIKEN-RAL muon facility (and partly at TRIUMF) is reported. The topics covered are magnetic field effect, muon transfer to {sup 3}He in solid D/T and ortho-para effect in dd{mu} formation.