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Sample records for controller ip core

  1. Challenges Regarding IP Core Functional Reliability

    Science.gov (United States)

    Berg, Melanie D.; LaBel, Kenneth A.

    2017-01-01

    For many years, intellectual property (IP) cores have been incorporated into field programmable gate array (FPGA) and application specific integrated circuit (ASIC) design flows. However, the usage of large complex IP cores were limited within products that required a high level of reliability. This is no longer the case. IP core insertion has become mainstream including their use in highly reliable products. Due to limited visibility and control, challenges exist when using IP cores and subsequently compromise product reliability. We discuss challenges and suggest potential solutions to critical application IP insertion.

  2. Ahb Compatible DDR Sdram Controller Ip Core for Arm Based Soc

    CERN Document Server

    Shashikumar, Dr R; Nagendrakumar, M; Hemanthkumar, C S

    2010-01-01

    DDR SDRAM is similar in function to the regular SDRAM but doubles the bandwidth of the memory by transferring data on both edges of the clock cycles. DDR SDRAM most commonly used in various embedded application like networking, image or video processing, Laptops ete. Now a days many applications needs more and more cheap and fast memory. Especially in the field of signal processing, requires significant amount of memory. The most used type of dynamic memory for that purpose is DDR SDRAM. For FPGA design the IC manufacturers are providing commercial memory controller IP cores working only on their products. Main disadvantage is the lack of memory access optimization for random memory access patterns. The data path part of those controllers can be used free of charge. This work propose an architecture of a DDR SDRAM controller, which takes advantage of those available and well tested data paths and can be used for any FPGA device or ASIC design.(5). In most of the SOC design, DDR SDRAM is commonly used. ARM pro...

  3. Designing High-Performance Fuzzy Controllers Combining IP Cores and Soft Processors

    Directory of Open Access Journals (Sweden)

    Oscar Montiel-Ross

    2012-01-01

    Full Text Available This paper presents a methodology to integrate a fuzzy coprocessor described in VHDL (VHSIC Hardware Description Language to a soft processor embedded into an FPGA, which increases the throughput of the whole system, since the controller uses parallelism at the circuitry level for high-speed-demanding applications, the rest of the application can be written in C/C++. We used the ARM 32-bit soft processor, which allows sequential and parallel programming. The FLC coprocessor incorporates a tuning method that allows to manipulate the system response. We show experimental results using a fuzzy PD+I controller as the embedded coprocessor.

  4. USB Dual-Mode Function IP Core Development

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This paper describes the specification and implement of a Universal Serial Bus (USB) dual-mode function IP core used for embedded system. Controlled by micro controller/CPU, the novel IP core can function as a USB host controller or USB peripheral controller. When configured as a USB host controller, it supports all USB 1.1 transaction types; supports automatic preamble insertion, and automatic SOF generation and transmission. Otherwise, when it is configured as a USB device by a microprocessor, it operates as a USB peripheral controller compliant with USB2.0 specification.

  5. Design of IP Core for TRDB-LTM touch control based on Nios II%基于Nios II的TRDB-LTM触控IP核设计

    Institute of Scientific and Technical Information of China (English)

    雷松华; 郑铿

    2014-01-01

    Identifying the position coordinates of the touch input is an important feature of the touch screen.As the SOPC Builder system does not provide TRDB-LTM touchscreen driver,a TRDB-LTM touch control IP core based on Nios II design method is proposed.The coordinates of the touch point were identiifed correctly.Provided both the hardware and software design process.According to the test,the IP core designed by this method can be quickly and accurately identify the touch location coordinates,runs stable and reliable.%对触点位置坐标识别与输入是触摸液晶屏的重要功能。由于SOPC Builder系统没有提供TRDB-LTM触摸屏的驱动,因而提出了一种基于Avalon总线的TRDB-LTM触控IP核的设计方法。实现TRDB-LTM触控屏触碰位置坐标的准确录入。给出系统硬、软件设计过程。经测试,所设计的IP核能够准确快速的识别触碰位置坐标,工作稳定可靠。

  6. Mobile location services over the next generation IP core network

    DEFF Research Database (Denmark)

    Thongthammachart, Saowanee; Olesen, Henning

    2003-01-01

    network is changing from circuit-switched to packet-switched technology and evolving to an IP core network based on IPv6. The IP core network will allow all IP devices to be connected seamlessly. Due to the movement detection mechanism of Mobile IPv6, mobile terminals will periodically update......Mobile communication networks are evolving towards smaller cells, higher throughput, better security and provision of better services. Wireless short-range technologies, such as the WLAN 802.11 standards family and Bluetooth, are expected to play a major role in future networks. The mobile core...... their current point of attachment to the network and hence provide the current location of the mobile user automatically. The convergence of wireless short-range networks, mobile networks and Internet technology will provide the mobile user's location without any add-in equipment for location measurement...

  7. At-Speed Logic BIST for IP Cores

    CERN Document Server

    Cheon, B; Wang, L -T; Wen, X; Hsu, P; Cho, J; Park, J; Chao, H; Wu, S

    2011-01-01

    This paper describes a flexible logic BIST scheme that features high fault coverage achieved by fault-simulation guided test point insertion, real at-speed test capability for multi-clock designs without clock frequency manipulation, and easy physical implementation due to the use of a low-speed SE signal. Application results of this scheme to two widely used IP cores are also reported.

  8. IP cores design from specifications to production modeling, verification, optimization, and protection

    CERN Document Server

    Mohamed, Khaled Salah

    2016-01-01

    This book describes the life cycle process of IP cores, from specification to production, including IP modeling, verification, optimization, and protection. Various trade-offs in the design process are discussed, including  those associated with many of the most common memory cores, controller IPs  and system-on-chip (SoC) buses. Readers will also benefit from the author’s practical coverage of new verification methodologies. such as bug localization, UVM, and scan-chain.  A SoC case study is presented to compare traditional verification with the new verification methodologies. ·         Discusses the entire life cycle process of IP cores, from specification to production, including IP modeling, verification, optimization, and protection; ·         Introduce a deep introduction for Verilog for both implementation and verification point of view.  ·         Demonstrates how to use IP in applications such as memory controllers and SoC buses. ·         Describes a new ver...

  9. Controlling IP Falsifying Using Realistic Simulation

    Directory of Open Access Journals (Sweden)

    Govindavaram Madhusri

    2013-07-01

    Full Text Available The study of Internet-scale events such as worm proliferation, distributed denial-of-service attacks (DDoS,flash crowds, routing volatilities, and DNS attacks depend on the formation of all the networks thatgenerate or forward valid and malevolent traffic,The Distributed Denial of Services (DDoS attack is aserious threat to the valid use of the Internet. Forestalling mechanisms are disappointed by the ability ofattackers to steal, or spoof, the source addresses in IP packets. IP falsifying is still widespread in networkscanning and investigates, as well as denial of service floods.IDPFs can limit the falsifying capability ofattackers. Moreover, it works on a small number of candidate networks easily traceable, thus simplifyingthe reactive IP trace back process. However, this technique does not allow large number of networks,which is a common misapprehension for those unfamiliar with the practice. Current network simulatorscannot be used to study Internet-scale events. They are general-purpose, packet-level simulators thatreproduce too many details of network communication, which limits scalability. We propose to develop adistributed Internet simulator, with the following novel features. It will provide a built-in Internet model,including the topology, routing, link bandwidths and delays, Instead of being a general-purpose simulator,it will provide a common simulation core for traffic generation and message passing, on top of which wewill build separate modules that customize messages and level of simulation details for the event of interest.Customization modules will ensure that all and only the relevant details of the event of interest aresimulated, cutting down the simulation time. We will also provide an interface for new modulespecification, and for existing module modification, this will bring the Internet event simulation at thefingertips of all interested researchers. The simulator will promote research in worm detection and defense,IP

  10. 用于混合信号VLSI的可扩展JTAG控制器IP核设计%Design of Extendable JTAG Controller IP Core for Mixed-signal VLSI

    Institute of Scientific and Technical Information of China (English)

    段延亮; 魏廷存; 高武; 许望洋

    2012-01-01

    The front-end read-out circuit for Positron Emission Tomography(PET) imaging system is a kind of digital-analog mixed-signal VLSI.Based on the features of multi-channel and high performances of these kinds of chip,the JTAG controller is adopted to realize the initial control and auxiliary test of the chip.An extendable JTAG controller IP core is designed using TSMC 0.18 μm CMOS process,which supports 14 groups of extendable control signal and also supports the reading and writing operations of 16 multi-bits registers scan chains,and joins with the customized substrate driving software.The designed JTAG controller IP core can be also used for the controlling and testing of other mixed-signal VLSI,and has good universality and engineering usage.%正电子发射断层成像系统(PET)前端读出电路是数模混合信号超大规模集成电路芯片.针对多通道高性能PET专用集成电路芯片的特点,采用JTAG控制器对该芯片进行初始控制和辅助测试.采用TSMC 0.18μmCMOS工艺设计实现了一个可扩展的JTAG控制器IP核,支持14组可扩展控制信号和16个多位寄存器扫描链的读/写操作,并配备定制的底层驱动软件.该JTAG控制器IP核还可用于其它混合信号VLSI的控制与测试,具有较强的通用性和工程实用价值.

  11. Embedded TCP/IP Chip Based on DW8051 Core

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    As remote control for electric home appliances thro ug h the Internet becomes more common, many compannies today launched a new corpora te initiative to develop advanced embedded solutions for Internet connectivity t hat can be applied to a boundless number of products such as information applian ces and non-PC devices. The most representative products are CMX-MicroNet which provides true TCP/IP ca pabilities for 8-bit and 16-bit microprocessors and eZ80Internet Engine which provides easy Internet connect...

  12. Research on DDS IP Core Based on FPGA%基于 FPGA 的 DDS IP 核的研究与设计

    Institute of Scientific and Technical Information of China (English)

    万志江

    2013-01-01

      针对传统的用单片机和 DDS 芯片设计高频信号发生器的方法具有的硬件结构复杂、人机交互性差和低可移植性等问题,提出了一种实现高频信号发生器功能的直接数字频率合成器(DDS)IP 软核的设计方法。本设计首先通过加权的方法实现十进制向二进制的转换,提高 IP 核的人机交互性,并引入 streamlined 算法在 FPGA 上实现频率控制字产生单元,解决传统设计中硬件结构复杂的问题。然后,在 ISE 设计平台上采用 Verilog HDL 硬件描述语言进行 DDS 行为描述,连接频率控制字产生单元,实现一个可重载的 DDS IP 软核。最后,在 XILINX SEED XDTK V5实验平台上对 IP 核进行板级验证。验证结果表明,此 IP 核具有良好的人机交互性和可移植性,能够很好的满足实际应用。%According to the complexity of hardware structure , the poor human‐computer interaction and low portability in designing a high frequency signal generator by MCU and DDS chip ,a direct digital frequency synthesis (DDS) IP soft‐core which has a function of high‐frequency signal generator is designed .In order to improve the human‐computer interaction , we convert decimal to binary by the method of weighted , and use streamlined algorithm to create the frequency control word so that we can solve the complexity of hardware structure in the traditional way . Meanwhile , Verilog HDL hardware desiption language is applied to realize the DDS behavior description and achieve an overloaded DDS IP core on the ISE platform .At last ,the board‐level verification of the IP core is developed on the XILINX SEED XDTK V5 platform .It is demonstrated experimentally that the IP core can satisfy the practical application with a good human‐computer interaction and high portability .

  13. Legal Protection on IP Cores for System-on-Chip Designs

    Science.gov (United States)

    Kinoshita, Takahiko

    The current semiconductor industry has shifted from vertical integrated model to horizontal specialization model in term of integrated circuit manufacturing. In this circumstance, IP cores as solutions for System-on-Chip (SoC) have become increasingly important for semiconductor business. This paper examines to what extent IP cores of SoC effectively can be protected by current intellectual property system including integrated circuit layout design law, patent law, design law, copyright law and unfair competition prevention act.

  14. In silico pooling of ChIP-seq control experiments.

    Science.gov (United States)

    Sun, Guannan; Srinivasan, Rajini; Lopez-Anido, Camila; Hung, Holly A; Svaren, John; Keleş, Sündüz

    2014-01-01

    As next generation sequencing technologies are becoming more economical, large-scale ChIP-seq studies are enabling the investigation of the roles of transcription factor binding and epigenome on phenotypic variation. Studying such variation requires individual level ChIP-seq experiments. Standard designs for ChIP-seq experiments employ a paired control per ChIP-seq sample. Genomic coverage for control experiments is often sacrificed to increase the resources for ChIP samples. However, the quality of ChIP-enriched regions identifiable from a ChIP-seq experiment depends on the quality and the coverage of the control experiments. Insufficient coverage leads to loss of power in detecting enrichment. We investigate the effect of in silico pooling of control samples within multiple biological replicates, multiple treatment conditions, and multiple cell lines and tissues across multiple datasets with varying levels of genomic coverage. Our computational studies suggest guidelines for performing in silico pooling of control experiments. Using vast amounts of ENCODE data, we show that pairwise correlations between control samples originating from multiple biological replicates, treatments, and cell lines/tissues can be grouped into two classes representing whether or not in silico pooling leads to power gain in detecting enrichment between the ChIP and the control samples. Our findings have important implications for multiplexing samples.

  15. Research study on IPS digital controller design

    Science.gov (United States)

    Kuo, B. C.; Folkerts, C.

    1976-01-01

    The performance is investigated of the simplified continuous-data model of the Instrument Pointing System (IPS). Although the ultimate objective is to study the digital model of the system, knowledge on the performance of the continuous-data model is important in the sense that the characteristics of the digital system should approach those of the continuous-data system as the sampling period approaches zero.

  16. A Novel Smart Meter Controlling System with Dynamic IP Addresses

    DEFF Research Database (Denmark)

    Manembu, Pinrolinvic; Welang, Brammy; Kalua Lapu, Aditya

    2017-01-01

    Smart meters are the electronic devices for measuring energy consumption in real time. Usually, static public IP addresses are allocated to realize the point-to-point (P2P) communication and remote controlling for smart metering systems. This, however, restricts the wide deployment of smart meters......, due to the deficiency of public IP resources. This paper proposes a novel subscription-based communication architecture for the support of dynamic IP addresses and group controlling of smart meters. The paper evaluates the proposed architecture by comparing the traditional P2P architecture......, and validate its effectiveness to interact with smart meters....

  17. REAL TIME TCP/IP CONTROL OF MODULAR PRODUCTION SYSTEMS WITH FPGAS

    Directory of Open Access Journals (Sweden)

    A. Castillo-Atoche

    2007-04-01

    Full Text Available The Modular Production System (MPS can be used to reproduce nearly any function in complex manufacturing processes. In this work a different way of real time TCP/IP control of three different MPS controlled by embedded processors inside a FPGA is proposed. The digital design with FPGA is particularly advantageous due to its parallel processing made possible by its flexible structure, high integration and velocity. The TCP/IP control is carried out with a Rabbit Core microprocessor. This device contains the functions required to implement a web server allowing the remote control of the MPS. A user enters a public IP direction on a designed web page to enable/disable each independent manufacturing process.

  18. Traffic Measurement for Traffic Engineering in IP/MPLS Based Telecom Core Networks

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Telecommunication networks will become IP-based networks with all voice, data and multimedia traffic carried as packets with appropriate quality and class of service for each traffic type. It is very important for service provider to apply Traffic Engineering (TE) with the dramatic growth of networks traffic. In this paper, we discuss traffic engineering based on IP/MPLS and emphasize traffic measurement in telecom core networks. We specify the technology and scientific principles of the measurement, modeling, characterization, and the traffic flow matrix. The paper concludes with a preliminary analysis of TE measurement and a discussion about the development of TE measurement.

  19. Fault-Tolerant Design and Testing of USB2.0 Peripheral Devices IP Core System

    Institute of Scientific and Technical Information of China (English)

    BAI Xiaoping; WEI Yuanfeng

    2007-01-01

    Universal serial bus 2.0 (USB2.0) is a kind of mainstream interface technology. The traditional USB developing is only to develop USB peripheral devices. For the USB2.0 peripheral devices IP core system that has wide application foreground, some interference inevitably exists in signal transmitting. Some fault-tolerant design and test methods must be adopted in order to correctly transmit and receive data. Combining with a project, this paper introduces in detail about measures, hardware implement, and test methods of fault-tolerant design about USB2.0 peripheral devices IP core system. Fault-tolerant design measures, noise reduction measures of signal processing, fault-tolerant methods about data encode and decode, package identification (ID) field fault-tolerant methods, and cyclic redundancy checks fault-tolerant methods are discussed. The paper also presents some hardware implement methods about fault-tolerant design of data decode and test methods about fault-tolerant design of USB2.0 IP core system. These methods can offer the reference for development of USB2.0 system in all kinds of electronics instrumentations.

  20. Core-based Shared Tree Multicast Routing Algorithms for LEO Satellite IP Networks

    Institute of Scientific and Technical Information of China (English)

    Cheng Lianzhen; Zhang Jun; Liu Kai

    2007-01-01

    A new core-based shared tree algorithm, viz core-cluster combination-based shared tree (CCST) algorithm and the weighted version (i.e. w-CCST algorithm) are proposed in order to resolve the channel resources waste problem in typical source-based multicast routing algorithms in low earth orbit (LEO) satellite IP networks. The CCST algorithm includes the dynamic approximate center (DAC)core selection method and the core-cluster combination multicast route construction scheme. Without complicated onboard computation,the DAC method is uniquely developed for highly dynamic networks of periodical and regular movement. The core-cluster combination method takes core node as the initial core-cluster, and expands it stepwise to construct an entire multicast tree at the lowest tree cost by a shortest path scheme between the newly-generated core-cluster and surplus group members, which results in great bandwidth utilization.Moreover, the w-CCST algorithm is able to strike a balance between performance of tree cost and that of end-to-end propagation delay by adjusting the weighted factor to meet strict end-to-end delay requirements of some real-time multicast services at the expense of a slight increase in tree cost. Finally, performance comparison is conducted between the proposed algorithms and typical algorithms in LEO satellite IP networks. Simulation results show that the CCST algorithm significantly decreases the average tree cost against to the others, and also the average end-to-end propagation delay of w-CCST algorithm is lower than that of the CCST algorithm.

  1. Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

    Directory of Open Access Journals (Sweden)

    Hiroyuki Oshiumi

    Full Text Available The DEAD box helicase DDX3 assembles IPS-1 (also called Cardif, MAVS, or VISA in non-infected human cells where minimal amounts of the RIG-I-like receptor (RLR protein are expressed. DDX3 C-terminal regions directly bind the IPS-1 CARD-like domain as well as the N-terminal hepatitis C virus (HCV core protein. DDX3 physically binds viral RNA to form IPS-1-containing spots, that are visible by confocal microscopy. HCV polyU/UC induced IPS-1-mediated interferon (IFN-beta promoter activation, which was augmented by co-transfected DDX3. DDX3 spots localized near the lipid droplets (LDs where HCV particles were generated. Here, we report that HCV core protein interferes with DDX3-enhanced IPS-1 signaling in HEK293 cells and in hepatocyte Oc cells. Unlike the DEAD box helicases RIG-I and MDA5, DDX3 was constitutively expressed and colocalized with IPS-1 around mitochondria. In hepatocytes (O cells with the HCV replicon, however, DDX3/IPS-1-enhanced IFN-beta-induction was largely abrogated even when DDX3 was co-expressed. DDX3 spots barely merged with IPS-1, and partly assembled in the HCV core protein located near the LD in O cells, though in some O cells IPS-1 was diminished or disseminated apart from mitochondria. Expression of DDX3 in replicon-negative or core-less replicon-positive cells failed to cause complex formation or LD association. HCV core protein and DDX3 partially colocalized only in replicon-expressing cells. Since the HCV core protein has been reported to promote HCV replication through binding to DDX3, the core protein appears to switch DDX3 from an IFN-inducing mode to an HCV-replication mode. The results enable us to conclude that HCV infection is promoted by modulating the dual function of DDX3.

  2. Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

    Science.gov (United States)

    Oshiumi, Hiroyuki; Ikeda, Masanori; Matsumoto, Misako; Watanabe, Ayako; Takeuchi, Osamu; Akira, Shizuo; Kato, Nobuyuki; Shimotohno, Kunitada; Seya, Tsukasa

    2010-12-08

    The DEAD box helicase DDX3 assembles IPS-1 (also called Cardif, MAVS, or VISA) in non-infected human cells where minimal amounts of the RIG-I-like receptor (RLR) protein are expressed. DDX3 C-terminal regions directly bind the IPS-1 CARD-like domain as well as the N-terminal hepatitis C virus (HCV) core protein. DDX3 physically binds viral RNA to form IPS-1-containing spots, that are visible by confocal microscopy. HCV polyU/UC induced IPS-1-mediated interferon (IFN)-beta promoter activation, which was augmented by co-transfected DDX3. DDX3 spots localized near the lipid droplets (LDs) where HCV particles were generated. Here, we report that HCV core protein interferes with DDX3-enhanced IPS-1 signaling in HEK293 cells and in hepatocyte Oc cells. Unlike the DEAD box helicases RIG-I and MDA5, DDX3 was constitutively expressed and colocalized with IPS-1 around mitochondria. In hepatocytes (O cells) with the HCV replicon, however, DDX3/IPS-1-enhanced IFN-beta-induction was largely abrogated even when DDX3 was co-expressed. DDX3 spots barely merged with IPS-1, and partly assembled in the HCV core protein located near the LD in O cells, though in some O cells IPS-1 was diminished or disseminated apart from mitochondria. Expression of DDX3 in replicon-negative or core-less replicon-positive cells failed to cause complex formation or LD association. HCV core protein and DDX3 partially colocalized only in replicon-expressing cells. Since the HCV core protein has been reported to promote HCV replication through binding to DDX3, the core protein appears to switch DDX3 from an IFN-inducing mode to an HCV-replication mode. The results enable us to conclude that HCV infection is promoted by modulating the dual function of DDX3.

  3. Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction

    OpenAIRE

    2010-01-01

    The DEAD box helicase DDX3 assembles IPS-1 (also called Cardif, MAVS, or VISA) in non-infected human cells where minimal amounts of the RIG-I-like receptor (RLR) protein are expressed. DDX3 C-terminal regions directly bind the IPS-1 CARD-like domain as well as the N-terminal hepatitis C virus (HCV) core protein. DDX3 physically binds viral RNA to form IPS-1-containing spots, that are visible by confocal microscopy. HCV polyU/UC induced IPS-1-mediated interferon (IFN)-beta promoter activation,...

  4. The CASCAM network control system based on TCP/IP

    Science.gov (United States)

    Ren, S. B.; Yao, Y. Q.; Yao, D. Z.

    2004-05-01

    The paper presents the CASCAM network control system based on the TCP/IP protocol. In order to realize the Client/Server model in network communication between the workstation and personal computer efficiently, two C++ classes, client and server, were developed in the system. The script language Tcl/Tk was used in programming the system control pane in the Client. With loading the dynamic library, the Client sends the request to the Server through the network, then the Server analyzes the request and controls the camera system.

  5. Integrated Control Plane for IP Enabled Optical Networks

    Institute of Scientific and Technical Information of China (English)

    LIZhengbin; YINHongxi; YUDeming; XUAnshi

    2003-01-01

    With the exponential growth of the Internet traffle for the intense demand for broadband services,providing bandwidth and connectivity on demand has risen to be a hot topic involving establishing connections from client ent systems to another through the optical backbone.So that,control plane and signaling in the optical network seems to be a critical component.This paper proposes and integrated control plane(ICP)and signaling related in IP enabled optical networks.Signaling processing for ensuring dynamic end-to-end lightpath setup has also been presented.Path provisioning comprises a string of operations like service & neighbor discovery,route computation,signaling requests,and path setup.

  6. Internetworking with Internet Protocol (IP) and Transmission Control Protocol (TCP) within the Military

    OpenAIRE

    Eikenberg, Bruce R.

    1990-01-01

    Approved for public release; distribution is unlimited. The backbone of the internetworking technology widely used by the military, as well as many civilian installations, is commonly referred to as TCP/IP. Transmission Control Protocol (TCP) and Internet Protocol (IP) are the two standard communication protocols from which TCP/IP receives its name. By utilizing TCP/IP, the majority of technical issues of interconnecting various computer technologies have become transparent to the user. Th...

  7. Xilinx DDR2 IP核控制器设计%Design of Xilinx DDR2 IP Controller

    Institute of Scientific and Technical Information of China (English)

    邹连英; 余峰

    2012-01-01

    提出一种便于用户操作并能快速运用到产品的DDR2控制器IP核的FPGA实现,使用户不需要了解DDR2的原理和操作方式的情况下,依然可以通过IP核控制DDR2。简单介绍了DDR2的特点和操作原理,并对DDR2控制器的IP核进行了模块化的划分,分析了每个模块的功能。强调了用户接口功能的完善,并介绍了IP核的操作流程,使每个用户都能轻松的使用该IP核。%This paper presents a DDR2 Controller IP core of FPGA implementation which user-friendly and quickly applied to the product. The IP core allows the user does not need to understand the principles and practices DDR2 circumstances, and can still control the DDR2. This thesis briefly introduces that the characteristics and operating principles of DDR2, and analyze that the function of each module in the DDR2 controller IP core. Emphasized the function of the perfect user interface, described the IP core operational processes in the paper, so that each user can easily use the IP core.

  8. Predictive IP controller for robust position control of linear servo system.

    Science.gov (United States)

    Lu, Shaowu; Zhou, Fengxing; Ma, Yajie; Tang, Xiaoqi

    2016-07-01

    Position control is a typical application of linear servo system. In this paper, to reduce the system overshoot, an integral plus proportional (IP) controller is used in the position control implementation. To further improve the control performance, a gain-tuning IP controller based on a generalized predictive control (GPC) law is proposed. Firstly, to represent the dynamics of the position loop, a second-order linear model is used and its model parameters are estimated on-line by using a recursive least squares method. Secondly, based on the GPC law, an optimal control sequence is obtained by using receding horizon, then directly supplies the IP controller with the corresponding control parameters in the real operations. Finally, simulation and experimental results are presented to show the efficiency of proposed scheme.

  9. The IP Soft Core Design of JTAG Instruction Processor%JTAG指令处理器IP软核设计

    Institute of Scientific and Technical Information of China (English)

    董承; 何朝军; 吕彩霞

    2011-01-01

    This article raised a digit circuit IP soft core verification based on task flow. According to the design requirement of digit circuit IP soft core, it categorizes the original IP core and divides a complicated verification task into different sub-tasks according to the functions the IP core can achieve. Then it conducts verification of different sub-tasks and connects them into a specific soft core task aim and thus forms a task flow. This article chooses a part of complicated IP soft core for verification, divides into different tasks according to its functional structure and sets up a comprehensive task implementation model. Finally, from the verification result of Modelsim tool, we can see that the IP core verification that based on task flow can accurately categorize IP modules so as to avoid leaving out functions and verify all functions oflP cores.%边界扫描技术是一种应用于数字集成电路器件的标准化可测试性设计方法,它提供了对电路板上元件的功能、互连及相互间影响进行测试的一种新方案,极大地方便了系统电路的浏试。自从1990年2月JTAG与IEEE标准化委员会合作提出了“标准测试访问通道与边界扫描结构”的IEEE1149.1.1990标准以后,边界扫描技术得到了迅速发展和应用。JTAG指令处理器是边界扫描电路的核心部件,在对TAP控制器的仿真验证同时,讨论JTAG相关指令与边界扫描测试方式。

  10. Design of IP Camera Access Control Protocol by Utilizing Hierarchical Group Key

    Directory of Open Access Journals (Sweden)

    Jungho Kang

    2015-08-01

    Full Text Available Unlike CCTV, security video surveillance devices, which we have generally known about, IP cameras which are connected to a network either with or without wire, provide monitoring services through a built-in web-server. Due to the fact that IP cameras can use a network such as the Internet, multiple IP cameras can be installed at a long distance and each IP camera can utilize the function of a web server individually. Even though IP cameras have this kind of advantage, it has difficulties in access control management and weakness in user certification, too. Particularly, because the market of IP cameras did not begin to be realized a long while ago, systems which are systematized from the perspective of security have not been built up yet. Additionally, it contains severe weaknesses in terms of access authority to the IP camera web server, certification of users, and certification of IP cameras which are newly installed within a network, etc. This research grouped IP cameras hierarchically to manage them systematically, and provided access control and data confidentiality between groups by utilizing group keys. In addition, IP cameras and users are certified by using PKI-based certification, and weak points of security such as confidentiality and integrity, etc., are improved by encrypting passwords. Thus, this research presents specific protocols of the entire process and proved through experiments that this method can be actually applied.

  11. 基于NiosⅡ处理器的SVPWMIPCore设计%IP Core Design of SVPWM Based on Nios II Processor

    Institute of Scientific and Technical Information of China (English)

    杜晓

    2011-01-01

    为降低FPGA实现3电平SVPWM算法的复杂性,减小SVPWM模块所占用的资源,文中利用正弦函数和余弦函数的关系,采用小容量ROM提出了一种新的SVPWM控制算法。利用Verilog HDL实现了算法的硬件设计,并封装成IP核以方便设计复用,在Altera公司的DE2开发板上进行了设计验证,体现了SOPC嵌入式系统的灵活性和扩展性%In order to reduce the algorithm complexity of FPGA implementation for 3-level SVPWM and the resources occupied by the SVPWM module,the paper proposes a new SVPWM control algorithm by using the small capacity ROM and the relationship between sine and cosine functions.The hardware design of the algorithm is implemented by using Verilog HDL,and packaged into IP cores to facilitate design reuse.The design is tested and verified by Altera’s DE2 board,which shows the flexibility and expandability of the SOPC embedded system

  12. Application of Model Reference Adaptive Control System to Instrument Pointing System /IPS/

    Science.gov (United States)

    Waites, H. B.

    1979-01-01

    A Model Reference Adaptive Controller (MRAC) is derived for a Shuttle payload called the Instrument Pointing System (IPS). The unique features of this MRAC design are that total state feedback is not required, that the internal structure of the model is independent of the internal structure of the IPS, and that the model input is of bounded variation and not required a priori. An application of Liapunov's stability theorems is used to synthesize a control signal which assures MRAC asymptotic stability. Exponential observers are used to obtain the necessary state information to implement the control synthesis. Results are presented which show how effectively the MRAC can maneuver the IPS.

  13. Data exploration, quality control and statistical analysis of ChIP-exo/nexus experiments.

    Science.gov (United States)

    Welch, Rene; Chung, Dongjun; Grass, Jeffrey; Landick, Robert; Keles, Sündüz

    2017-09-06

    ChIP-exo/nexus experiments rely on innovative modifications of the commonly used ChIP-seq protocol for high resolution mapping of transcription factor binding sites. Although many aspects of the ChIP-exo data analysis are similar to those of ChIP-seq, these high throughput experiments pose a number of unique quality control and analysis challenges. We develop a novel statistical quality control pipeline and accompanying R/Bioconductor package, ChIPexoQual, to enable exploration and analysis of ChIP-exo and related experiments. ChIPexoQual evaluates a number of key issues including strand imbalance, library complexity, and signal enrichment of data. Assessment of these features are facilitated through diagnostic plots and summary statistics computed over regions of the genome with varying levels of coverage. We evaluated our QC pipeline with both large collections of public ChIP-exo/nexus data and multiple, new ChIP-exo datasets from Escherichia coli. ChIPexoQual analysis of these datasets resulted in guidelines for using these QC metrics across a wide range of sequencing depths and provided further insights for modelling ChIP-exo data. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  14. TCP/IP Communication System for Controlling a Vehicular Traffic Intersection

    Directory of Open Access Journals (Sweden)

    Pedraza-Martínez Luis Fernando

    2013-10-01

    Full Text Available This paper describes the development of a prototype of a vehicular traffic controller, whose system of communication is based on the TCP/IP protocol, in order to re- motely monitor and control the operation of traffic lights for a vehicular intersection. The results show the times of communication between the central and the traffic controller. The conclusions highlight the importance of using the TCP/IP protocol in traffic light systems.

  15. Three-dimensional FPGA Architecture Embedded with IP Cores%引入IP核的三维FPGA结构研究

    Institute of Scientific and Technical Information of China (English)

    唐强; 林郁; 刘洋; 杨海钢

    2016-01-01

    为研究IP核的引入对三维FPGA芯片性能的影响,提出引入IP核同质和粗粒度异质两种三维FPGA结构。首先,利用二维FPGA CAD开源软件构建基于IP核和三维开关盒的三维FPGA CAD工具。然后,利用该工具从定性和定量的角度对不同堆叠层数引入IP核的同质三维FPGA结构进行性能分析。实验发现,随着堆叠层数的增加,关键路径延迟逐渐减小;芯片总面积逐渐增加,单层芯片面积逐渐减小。与引入IP核的同质三维FPGA结构相比,粗粒度异质三维FPGA结构的关键路径延迟更小,表明该结构在减小延时方面的有效性。%In order to fathom the effect on three-dimensional FPGA performance after IP cores are integrated,two FPGA structures are introduced in this paper:homogeneous 3D FPGAs with IP cores and coarse-grained heterogeneous ones.In the first place,we developed a new FPGA CAD tool,which is an upgrade version of a 2D FPGA CAD tool,to support FPGAs based on IP cores and 3D switch boxes,then use it to analyze the homogeneous 3D FPGA performance in different layers in terms of quality and quantity.Experiments reveal the fact that with the number of chip layer increases,total chip area will rise,in the other hand,critical path delay and chip area per layer fall accordingly. Compared to the homogeneous 3D structured FPGAs (with IP cores ), coarse-grained heterogeneous ones have better critical path delay,which proves such structure has the effectiveness on reducing critical path delay.

  16. GMPLS: IP-Centric Control Protocols for Optical Networks(Tutorial)

    Institute of Scientific and Technical Information of China (English)

    Yaohui Jin; Weisheng Hu

    2003-01-01

    Recent advances in optical networking technologies, particularly DWDM and MEMS, promise the transmission and switching of huge bandwidth capacity. The carriers have convinced of that their revenue must be earned from efficient bandwidth management instead of unsophisticated increase in capacity. The distributed control plane can offer more flexibility, reliability and scalability, whose functions include addressing, resource and topology discovery, route computation, provisioning and restoration. Generalized Multi-Protocol Label Switching (GMPLS), an IP-centric control plane, inherit the best features of IP and ATM technologies in terms of QoS and traffic engineering. Besides,GMPLS introduces enhancements to the existing IP routing and signaling protocols by supporting not only packet switching networks (IP) and frame/cell switching networks (ATM), but also networks that perform switching in time (e.g. SDH/SONET, PDH, G.709), wavelength (lambdas), and space (fiber) domain.

  17. A Traffic Forecasting Method with Function to Control Residual Error Distribution for IP Access Networks

    Science.gov (United States)

    Kitahara, Takeshi; Furuya, Hiroki; Nakamura, Hajime

    Since traffic in IP access networks is less aggregated than in backbone networks, its variance could be significant and its distribution may be long-tailed rather than Gaussian in nature. Such characteristics make it difficult to forecast traffic volume in IP access networks for appropriate capacity planning. This paper proposes a traffic forecasting method that includes a function to control residual error distribution in IP access networks. The objective of the proposed method is to grasp the statistical characteristics of peak traffic variations, while conventional methods focus on average rather than peak values. In the proposed method, a neural network model is built recursively while weighting residual errors around the peaks. This enables network operators to control the trade-off between underestimation and overestimation errors according to their planning policy. Evaluation with a total of 136 daily traffic volume data sequences measured in actual IP access networks demonstrates the performance of the proposed method.

  18. Mobile IP

    NARCIS (Netherlands)

    Heijenk, Geert; Sallent, S.; Pras, A.

    1999-01-01

    The Internet is growing exponentially, both in the amount of traffic carried, and in the amount of hosts connected. IP technology is becoming more and more important, in company networks (Intranets), and also in the core networks for the next generation mobile networks. Further, wireless access to I

  19. Mobile IP

    NARCIS (Netherlands)

    Heijenk, Gerhard J.; Sallent, S.; Pras, Aiko

    1999-01-01

    The Internet is growing exponentially, both in the amount of traffic carried, and in the amount of hosts connected. IP technology is becoming more and more important, in company networks (Intranets), and also in the core networks for the next generation mobile networks. Further, wireless access to

  20. Improving Control Mechanism at Routers in TCP/IP Network

    Directory of Open Access Journals (Sweden)

    Nguyen Kim Quoc

    2014-09-01

    Full Text Available The existing control mechanisms at the network nodes have a good active and very effective at each local router, but they do not still strong enough to control nonlinear and dynamical behaviour of the network. Therefore, the control system requirements must be designed to be flexible to fully grasp the important status information of the variation and intelligent control methods to control network congestion in nonlinear network. To solve this problem, we propose a solution combined fuzzy reasoning with neural network control put on active queue management mechanisms at the network nodes.

  1. A comparison of control samples for ChIP-seq of histone modifications

    Directory of Open Access Journals (Sweden)

    Christoffer eFlensburg

    2014-09-01

    Full Text Available The advent of high-throughput sequencing has allowed genome wide profiling of histone modifications by Chromatin ImmunoPrecipitation (ChIP followed by sequencing (ChIP-seq. In this assay the histone mark of interest is enriched through a chromatin pull-down assay using an antibody for the mark. Due to imperfect antibodies and other factors, many of the sequenced fragments do not originate from the histone mark of interest, and are referred to as background reads. Background reads are not uniformly distributed and therefore control samples are usually used to estimate the background distribution at any given genomic position. The Encyclopedia of DNA Elements (ENCODE Consortium guidelines suggest sequencing a whole cell extract (WCE, or input sample, or a mock ChIP reaction such as an IgG control, as a background sample. However, for a histone modification ChIP-seq investigation it is also possible to use a Histone H3 (H3 pull-down to map the underlying distribution of histones.In this paper we generated data from a hematopoietic stem and progenitor cell population isolated from mouse foetal liver to compare WCE and H3 ChIP-seq as control samples. The quality of the control samples is estimated by a comparison to pull-downs of histone modifications and to expression data. We find minor differences between WCE and H3 ChIP-seq, such as coverage in mitochondria and behaviour close to transcription start sites. Where the two controls differ, the H3 pull-down is generally more similar to the ChIP-seq of histone modifications. However, the differences between H3 and WCE have a negligible impact on the quality of a standard analysis.

  2. A comparison of control samples for ChIP-seq of histone modifications.

    Science.gov (United States)

    Flensburg, Christoffer; Kinkel, Sarah A; Keniry, Andrew; Blewitt, Marnie E; Oshlack, Alicia

    2014-01-01

    The advent of high-throughput sequencing has allowed genome wide profiling of histone modifications by Chromatin ImmunoPrecipitation (ChIP) followed by sequencing (ChIP-seq). In this assay the histone mark of interest is enriched through a chromatin pull-down assay using an antibody for the mark. Due to imperfect antibodies and other factors, many of the sequenced fragments do not originate from the histone mark of interest, and are referred to as background reads. Background reads are not uniformly distributed and therefore control samples are usually used to estimate the background distribution at any given genomic position. The Encyclopedia of DNA Elements (ENCODE) Consortium guidelines suggest sequencing a whole cell extract (WCE, or "input") sample, or a mock ChIP reaction such as an IgG control, as a background sample. However, for a histone modification ChIP-seq investigation it is also possible to use a Histone H3 (H3) pull-down to map the underlying distribution of histones. In this paper we generated data from a hematopoietic stem and progenitor cell population isolated from mouse fetal liver to compare WCE and H3 ChIP-seq as control samples. The quality of the control samples is estimated by a comparison to pull-downs of histone modifications and to expression data. We find minor differences between WCE and H3 ChIP-seq, such as coverage in mitochondria and behavior close to transcription start sites. Where the two controls differ, the H3 pull-down is generally more similar to the ChIP-seq of histone modifications. However, the differences between H3 and WCE have a negligible impact on the quality of a standard analysis.

  3. [Effect of core: dentin thickness ratio on the flexure strength of IPS Empress II heat-pressed all-ceramic restorative material].

    Science.gov (United States)

    Liu, Yi-hong; Feng, Hai-lan; Bao, Yi-wang; Qiu, Yan

    2007-02-18

    To evaluate the effect of core:dentin thickness ratio on the flexure strength, fracture mode and origin of bilayered IPS Empress II ceramic composite specimens. IPS Empress II core ceramic, dentin porcelain and bilayered composite specimens with core:dentin thickness ratio of 2:1 and 1:1 were tested in three-point flexure strength. Mean strengths and standard deviations were determined. The optical microscopy was employed for identification of the fracture mode and origin. The flexure strength of dentin porcelain was the smallest(62.7 MPa), and the strength of bilayered composite specimens was smaller than single-layered core ceramic(190.2 MPa). The core: dentin ratio did not influence the strength of bilayered composite specimens. The frequency of occurrence of bilayered specimen delaminations was higher in the group of core: dentin thickness ratio of 1:1 than in the group of 2:1. IPS Empress II core ceramic was significantly stronger than veneering dentin porcelain. Core:dentin thickness ratio could significantly influence the fracture mode and origin, and bilayered IPS Empress II ceramic composite specimens showed little influence in the fracture strength.

  4. Efficient Control Channel Resource Allocation for VoIP in OFDMA-Based Packet Radio Networks

    Directory of Open Access Journals (Sweden)

    Fan Yong

    2011-01-01

    Full Text Available We propose an efficient control channel resource allocation approach to enhance the performance of voice-over-IP (VoIP in orthogonal frequency division multiple access- (OFDMA- based next generation mobile communication systems. As the long-term evolution (LTE of universal terrestrial radio access network (UTRAN, evolved UTRAN (E-UTRAN is the first OFDMA-based packet radio network and thus selected in this paper as an application example. Our proposed physical downlink control channel (PDCCH resource allocation approach for E-UTRAN is composed of bidirectional power control, inner loop link adaptation (ILLA, and outer loop link adaptation (OLLA algorithms. Its effectiveness is validated through large-scale radio system level simulations, and simulation results confirm that VoIP capacity with dynamic scheduling can be further enhanced with this PDCCH resource allocation approach. Moreover, the VoIP performance requirements for international mobile telecommunications-advanced (IMT-Advanced radio interface technologies can be met with dynamic scheduling together with proposed PDCCH resource allocation. Besides E-UTRAN, this approach can be introduced to other OFDMA-based mobile communication systems for VoIP performance enhancement as well.

  5. UART IP核的设计及其FPGA实现%Design and FPGA implementation of a UART IP core

    Institute of Scientific and Technical Information of China (English)

    贺春芝; 夏银水; 王伦耀

    2012-01-01

    为了提高UART IP核的可重用性和灵活性,将其中波特率发生器模块设计成自适应的波特率发生器,同时采用异步FIFO作为UART与外部数据交换的缓冲器,实现处理器与UART接口的速度匹配.以IP核的参数化设计为基础进行Verilog HDL编码,在Modelsim SE 6.0上进行仿真验证,然后应用Synplicity公司的Synplify Premier 9.6.2和Synopsys公司的DC 2008分别进行综合优化,并在FPGA上加以实现.结果显示,所提出的设计功能正确,可重用性强.%To improve the reusability and flexibility of the UART IP core, an auto-tuning baud rate generator is designed to replace the baud rate generator module. And for achieving the speed matching of the processor and UART interface, it takes asynchronous FIFOs as buffers to realize data exchange between UART and external devices. The proposed design, based on the parameterized design method of IP core, is described with Verilog-HDL. The whole design has been carried on the functional verification by Modelsim SE6. 0. In the end, it is synthesized and optimized by Synplicity company's Synplify Premier9. 6. 2 and Synopsys company's DC 2008 respectively and is implemented by FPGA. The results show that the function of the proposed design is correct and has good reusability.

  6. Resource management in radio access and IP-based core networks for IMT Advanced and Beyond

    Institute of Scientific and Technical Information of China (English)

    SU Gang; HIDELL Markus; ABRAHAMSSON Henrik; AHLGREN Bengt; LI Dan; SJDIN Peter; TANYINGYONG Voravit; XU Ke

    2013-01-01

    The increased capacity needs, primarily driven by content distribution, and the vision of Internet-of-Things with billions of connected devices pose radically new demands on future wireless and mobile systems. In general the increased diversity and scale result in complex resource management and optimization problems in both radio access networks and the wired core network infrastructure. We summarize results in this area from a collaborative Sino-Swedish project within IMT Advanced and Beyond, covering adaptive radio resource management, energy-aware routing, OpenFlow-based network virtualization, data center networking, and access network caching for TV on demand.

  7. Truncated power control for improving TCP/IP performance over CDMA wireless links

    DEFF Research Database (Denmark)

    Cianca, Ernestina; Prasad, Ramjee; De Sanctis, Mauro

    2005-01-01

    The issue of the performance degradation of transmission control protocol/Internet Protocol (TCP/IP) over wireless links due to the presence of noncongestion-related packet losses has been addressed with a physical layer approach. The effectiveness of automatic repeat request techniques in enhanc...

  8. Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks

    Directory of Open Access Journals (Sweden)

    Courdy Samir J

    2008-12-01

    Full Text Available Abstract Background High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone modifications, changes in chromatin structure and patterns of DNA methylation across entire genomes. In these experiments, chromatin immunoprecipitation is used to enrich for particular DNA sequences of interest and signature sequencing is used to map the regions to the genome (ChIP-Seq. Elucidation of these sites of DNA-protein binding/modification are proving instrumental in reconstructing networks of gene regulation and chromatin remodelling that direct development, response to cellular perturbation, and neoplastic transformation. Results Here we present a package of algorithms and software that makes use of control input data to reduce false positives and estimate confidence in ChIP-Seq peaks. Several different methods were compared using two simulated spike-in datasets. Use of control input data and a normalized difference score were found to more than double the recovery of ChIP-Seq peaks at a 5% false discovery rate (FDR. Moreover, both a binomial p-value/q-value and an empirical FDR were found to predict the true FDR within 2–3 fold and are more reliable estimators of confidence than a global Poisson p-value. These methods were then used to reanalyze Johnson et al.'s neuron-restrictive silencer factor (NRSF ChIP-Seq data without relying on extensive qPCR validated NRSF sites and the presence of NRSF binding motifs for setting thresholds. Conclusion The methods developed and tested here show considerable promise for reducing false positives and estimating confidence in ChIP-Seq data without any prior knowledge of the chIP target. They are part of a larger open source package freely available from http://useq.sourceforge.net/.

  9. Online industrial process broadcast and control based on IP and serial networks

    Directory of Open Access Journals (Sweden)

    Nicolae PARASCHIV

    2007-12-01

    Full Text Available The Internet network in conjunction with a strong security policy can be an ideal online broadcast system for the industrial processes monitoring and control. Because the distributed controllers are connected through industrial serial connection, the network between controllers cannot be extended very much. The problem appears when the plant is away and cannot be accessed via a serial connection. For administrative and control purposes the serial network can be interconnected with an IP network. In this case the operator can be anywhere in the world and can interact via an interface with the process. This paper will describe flow process remote controlled using a mixture of two communication technologies: RS485 and TCP/IP. The junction between these technologies is transparent and the operator is able to monitor the process using an interface console.

  10. Extensible Airborne Graphics Engine Design Based on IP Cores%基于IP核的可扩展机载图形引擎设计

    Institute of Scientific and Technical Information of China (English)

    汪溢; 陈少磊; 周坚锋

    2014-01-01

    Airborne graphics engine should maintain high graphics rendering performance while satisfying avionics unique requirements, such as reliability and extensibility, etc. This paper presented the shortcomings of traditional airborne graphics engine technology and introduced the implementation approaches of graphics IP cores for avionics application, it also presented an architecture for an extensible airborne graphics engine based on IP cores, which can strike a balance between graphics processing performance and extensibility. This solution meets demands of model based graphics application development, while satisfying the need of cost control and life cycle.%先进座舱显示系统要求新一代机载图形引擎必须在具备较强图形实时渲染性能的同时,满足可靠性、可扩展性等航空产品的特定需求。本文分析了传统机载图形引擎实现技术的局限性,给出了基于IP核的可扩展机载图形引擎架构及设计实现。这种图形引擎在图形渲染性能和可靠性、可扩展性等之间取得平衡,支持基于模型的图形软件开发,同时满足成本控制和长生命周期支持等需求。

  11. A source-based congestion control strategy for real-time video transport on IP network

    Science.gov (United States)

    Chen, Xia; Cai, Canhui

    2005-07-01

    The goal of this paper is to design a TCP friendly real-time video transport protocol that will not only utilize network resource efficiently, but also prevent network congestion from the real-time video transmitting effectively. To this end, we proposed a source based congestion control scheme to adapt video coding rate to the channel capacity of the IP network, including three stages: rate control, rate-adaptive video encoding, and rate shaping.

  12. Avalon总线SHT11的自定义IP核的开发%Development of SHT11 Customized IP Core Based on Avalon Bus

    Institute of Scientific and Technical Information of China (English)

    隋会静; 杨永杰

    2011-01-01

    This article briefly describes the SOPC and Avalon bus. The development process of the SHT11 customized IP core is introduced. This IP core adopts the nested state machine according to the device controiler specification and the timing request, then an embedded system on chip based on NiosII is built. CPU reads and writes SHT11 through the IP core. In the greenhouse of agriculture, the system accuracy is verified. The customized IP core can shorten the development cycle and reduce the workload when other users use SHT11 in the development.%首先简要介绍了SOPC和Avalon总线,详细阐述了温湿度传感器SHT1自定义IP核的开发流程.该IP核根据其驱动控制器的规范以及时序要求,利用SOPC的Avalon总线,采用嵌套状态机,构建了基于NiosⅡ嵌入式处理器片上系统.CPU通过自定义的IP核对SHT11控制读写,并在农业大棚中应用,测试所得数据准确.其他用户在使用SHT11进行项目开发时,SHT11自定义IP核可以缩短开发周期,降低工作量.

  13. SN 2009ip and SN 2010mc: Early and late-time behavior consistent with core-collapse Type IIn supernovae

    CERN Document Server

    Smith, Nathan; Prieto, Jose

    2013-01-01

    The recent supernova (SN) 2009ip had pre-SN eruptions followed by a final explosion in 2012. Its pre-SN observations make 2009ip the best observed SN progenitor in history, but the unprecedented data on the pre-SN activity has fueled debate about the nature of the 2012 explosion, whether it was a true SN or some extreme non-terminal event. In principle, both types of events could power shock interaction with circumstellar material (CSM), but here we argue that only a core-collapse SN provides a self-consistent explanation. Previously, we demonstrated that the light curves of SN 2009ip and another Type IIn, SN 2010mc, were nearly identical. Here we expand that comparison to their spectra as well, demonstrating that they are both consistent with known Type IIn events. The late-time spectra of SN 2009ip resemble those of the super-luminous SN 2006tf, and the underlying broad component in SN 2009ip's spectra resembles Type II-P events. The recent claim that the late-time spectrum of SN 2009ip is returning to its ...

  14. Telephony Over IP: A QoS Measurement-Based End to End Control Algorithm

    Directory of Open Access Journals (Sweden)

    Luigi Alcuri

    2004-12-01

    Full Text Available This paper presents a method for admitting voice calls in Telephony over IP (ToIP scenarios. This method, called QoS-Weighted CAC, aims to guarantee Quality of Service to telephony applications. We use a measurement-based call admission control algorithm, which detects network congested links through a feedback on overall link utilization. This feedback is based on the measures of packet delivery latencies related to voice over IP connections at the edges of the transport network. In this way we introduce a close loop control method, which is able to auto-adapt the quality margin on the basis of network load and specific service level requirements. Moreover we evaluate the difference in performance achieved by different Queue management configurations to guarantee Quality of Service to telephony applications, in which our goal was to evaluate the weight of edge router queue configuration in complex and real-like telephony over IP scenario. We want to compare many well-know queue scheduling algorithms, such as SFQ, WRR, RR, WIRR, and Priority. This comparison aims to locate queue schedulers in a more general control scheme context where different elements such as DiffServ marking and Admission control algorithms contribute to the overall Quality of Service required by real-time voice conversations. By means of software simulations we want to compare this solution with other call admission methods already described in scientific literature in order to locate this proposed method in a more general control scheme context. On the basis of the results we try to evidence the possible advantages of this QoS-Weighted solution in comparison with other similar CAC solutions ( in particular Measured Sum, Bandwidth Equivalent with Hoeffding Bounds, and Simple Measure CAC, on the planes of complexity, stability, management, tune-ability to service level requirements, and compatibility with actual network implementation.

  15. Design and implementation of IP Core of IEEE 1394b VersaPHY%IEEE 1394b VersaPHY的IP核设计与实现

    Institute of Scientific and Technical Information of China (English)

    朱榆涵; 邵洪峰; 伊小素; 龙映雪

    2012-01-01

    Implementations of VersaPHY IP core is presented. According to VersaPHY protocol, we analyse the VersaPHY labels, packages and register, and complete the design of VersaPHY IP core. In the Altera Quartus II development platform, combining with the Verilog HDL language and its own IP CORE realizes the reception and transmission of packets addressed by VP-Label (read request, read response packet, a write request, write response packets) . Finally we use SignalTap II logic analyzers which is provided by Quartus II integrated development environment to verify , the results show the functions of VersaPHY of IP core is implemented.%文章提出了VersaPHY的IP核的实现方案;根据VersaPHY协议,分析了VersaPHY的标签、数据包和寄存器,完成了VersaPHY的IP核设计;在Altera QuartusⅡ开发平台上,结合Verilog HDL语言和其自带的IP CORE实现了VP- Label寻址的数据包(读请求包、读响应包、写请求包、写响应包)的接收和发送;最后借助于QuartusⅡ集成开发环境提供的SignalTapⅡ逻辑分析仪进行验证,结果表明,该系统可以实现不同速度(100Mb/s、200Mb/s、400Mb/s、800Mb/s)的VersaPHY的数据包的传输,工作稳定可靠,满足实际应用需求.

  16. Uniform gold nanoarray formed by controlled IP6 micelles for chemical mapping

    Science.gov (United States)

    Chen, Xiyao; Wen, Ying; Wang, Na; Gu, Kai; Yang, Haifeng

    2011-05-01

    A uniform Au nanoarray is successfully formed at an indium tin oxide (ITO) glass surface modified with well-distributed inositol hexakisphosphoric (IP6) micelle layers by controlling the pH of the medium at 10. When Rhodamine 6G (R6G) and 2-mercaptopyridine (2-MPy) are used as the Raman probes, the uniform Au nanoarray presents a sound surface enhanced Raman scattering (SERS) efficiency and a reproducible Raman signal in two dimensions. The relative standard deviation (RSD) of Raman intensities of R6G or 2-MPy on the uniform Au nanoarray recorded by point to point is less than 12%, which is beneficial to its application for chemical mapping or imaging. A case of Raman point-mapping for onion epidermis is demonstrated in the present work. A uniform IP6-Au nanoarray might be mass-produced by this protocol.

  17. Voice Over Internet Protocol (VoIP) in a Control Center Environment

    Science.gov (United States)

    Pirani, Joseph; Calvelage, Steven

    2010-01-01

    The technology of transmitting voice over data networks has been available for over 10 years. Mass market VoIP services for consumers to make and receive standard telephone calls over broadband Internet networks have grown in the last 5 years. While operational costs are less with VoIP implementations as opposed to time division multiplexing (TDM) based voice switches, is it still advantageous to convert a mission control center s voice system to this newer technology? Marshall Space Flight Center (MSFC) Huntsville Operations Support Center (HOSC) has converted its mission voice services to a commercial product that utilizes VoIP technology. Results from this testing, design, and installation have shown unique considerations that must be addressed before user operations. There are many factors to consider for a control center voice design. Technology advantages and disadvantages were investigated as they refer to cost. There were integration concerns which could lead to complex failure scenarios but simpler integration for the mission infrastructure. MSFC HOSC will benefit from this voice conversion with less product replacement cost, less operations cost and a more integrated mission services environment.

  18. The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.

    Science.gov (United States)

    Vazquez-Martin, Alejandro; Corominas-Faja, Bruna; Cufi, Sílvia; Vellon, Luciano; Oliveras-Ferraros, Cristina; Menendez, Octavio J; Joven, Jorge; Lupu, Ruth; Menendez, Javier A

    2013-01-15

    Induced pluripotent stem (iPS) cells share some basic properties, such as self-renewal and pluripotency, with cancer cells, and they also appear to share several metabolic alterations that are commonly observed in human tumors. The cancer cells' glycolytic phenotype, first reported by Otto Warburg, is necessary for the optimal routing of somatic cells to pluripotency. However, how iPS cells establish a Warburg-like metabolic phenotype and whether the metabolic pathways that support the bioenergetics of iPS cells are produced by the same mechanisms that are selected during the tumorigenic process remain largely unexplored. We recently investigated whether the reprogramming-competent metabotype of iPS cells involves changes in the activation/expression status of the H(+)-ATPase, which is a core component of mitochondrial oxidative phosphorylation that is repressed at both the activity and protein levels in human carcinomas, and of the lipogenic switch, which refers to a marked overexpression and hyperactivity of the acetyl-CoA carboxylase (ACACA) and fatty acid synthase (FASN) lipogenic enzymes that has been observed in nearly all examined cancer types. A comparison of a starting population of mouse embryonic fibroblasts and their iPS cell progeny revealed that somatic cell reprogramming involves a significant increase in the expression of ATPase inhibitor factor 1 (IF1), accompanied by extremely low expression levels of the catalytic β-F1-ATPase subunit. The pharmacological inhibition of ACACA and FASN activities markedly decreases reprogramming efficiency, and ACACA and FASN expression are notably upregulated in iPS cells. Importantly, iPS cells exhibited a significant intracellular accumulation of neutral lipid bodies; however, these bodies may be a reflection of intense lysosomal/autophagocytic activity rather than bona fide lipid droplet formation in iPS cells, as they were largely unresponsive to pharmacological modulation of PPARgamma and FASN activities. The

  19. Zerone: a ChIP-seq discretizer for multiple replicates with built-in quality control

    Science.gov (United States)

    Cuscó, Pol; Filion, Guillaume J.

    2016-01-01

    Motivation: Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the standard method to investigate chromatin protein composition. As the number of community-available ChIP-seq profiles increases, it becomes more common to use data from different sources, which makes joint analysis challenging. Issues such as lack of reproducibility, heterogeneous quality and conflicts between replicates become evident when comparing datasets, especially when they are produced by different laboratories. Results: Here, we present Zerone, a ChIP-seq discretizer with built-in quality control. Zerone is powered by a Hidden Markov Model with zero-inflated negative multinomial emissions, which allows it to merge several replicates into a single discretized profile. To identify low quality or irreproducible data, we trained a Support Vector Machine and integrated it as part of the discretization process. The result is a classifier reaching 95% accuracy in detecting low quality profiles. We also introduce a graphical representation to compare discretization quality and we show that Zerone achieves outstanding accuracy. Finally, on current hardware, Zerone discretizes a ChIP-seq experiment on mammalian genomes in about 5 min using less than 700 MB of memory. Availability and Implementation: Zerone is available as a command line tool and as an R package. The C source code and R scripts can be downloaded from https://github.com/nanakiksc/zerone. The information to reproduce the benchmark and the figures is stored in a public Docker image that can be downloaded from https://hub.docker.com/r/nanakiksc/zerone/. Contact: guillaume.filion@gmail.com Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27288492

  20. The effect of IPS on participants' engagement, quality of life, empowerment, and motivation: a randomized controlled trial.

    Science.gov (United States)

    Areberg, Cecilia; Bejerholm, Ulrika

    2013-11-01

    To investigate the effectiveness of Individual Placement and Support (IPS) with regard to non-vocational outcomes among individuals with severe mental illness. A randomized controlled trial was carried out, comparing IPS with traditional vocational rehabilitation. The Empowerment Scale, the Worker Role Interview, the Profile of Occupational Engagement, and the Manchester Short Assessment of Quality of Life were administered to 120 clients, at baseline, six, and 18 months. IPS participants showed higher scores in quality of life (p = 0.002), empowerment (p = 0.047), and work motivation (p = 0.033) at 18 months. Within the IPS group, a significant change in QOL was shown at six (p = 0.002) and 18 months (p = 0.000), and in occupational engagement (p = 0.003; p = 0.012). IPS can be part of a recovery process as individuals may increase their life satisfaction and time spent in daily occupations and community life.

  1. Fast remote data access for control of TCP/IP network using android Mobile device

    Directory of Open Access Journals (Sweden)

    Vaibhav Muddebihalkar

    2014-04-01

    Full Text Available In this paper we will creating architecture which will helps user to control LAN using the android mobile. As the most of the all application are now creating the cross platform version for the android, we will also make the control using the android platform. This is purely network administrative application which useful for the controlling network. The architecture will consist the nodes in the LAN and one server as well as one android phone which use to control the nodes. We use connectivity options as Wi-Fi or Internet; if connectivity internet is taken in grant then we will provide the static IP address to the server. For all this kind of application we should use JAVA technology and the android SDK in programming point of view. After testing application on LAN it works very well while file browsing and controlling the process.

  2. A TCP/IP framework for ethernet-based measurement, control and experiment data distribution

    Science.gov (United States)

    Ocaya, R. O.; Minny, J.

    2010-11-01

    A complete modular but scalable TCP/IP based scientific instrument control and data distribution system has been designed and realized. The system features an IEEE 802.3 compliant 10 Mbps Medium Access Controller (MAC) and Physical Layer Device that is suitable for the full-duplex monitoring and control of various physically widespread measurement transducers in the presence of a local network infrastructure. The cumbersomeness of exchanging and synchronizing data between the various transducer units using physical storage media led to the choice of TCP/IP as a logical alternative. The system and methods developed are scalable for broader usage over the Internet. The system comprises a PIC18f2620 and ENC28j60 based hardware and a software component written in C, Java/Javascript and Visual Basic.NET programming languages for event-level monitoring and browser user-interfaces respectively. The system exchanges data with the host network through IPv4 packets requested and received on a HTTP page. It also responds to ICMP echo, UDP and ARP requests through a user selectable integrated DHCP and static IPv4 address allocation scheme. The round-trip time, throughput and polling frequency are estimated and reported. A typical application to temperature monitoring and logging is also presented.

  3. In Vitro Effect of Porcelain Firing Cycle and Different Thicknesses of IPS E.max CAD Core on Marginal Accuracy of All-Ceramic Restorations

    Directory of Open Access Journals (Sweden)

    Ezatollah Jalalian

    2016-08-01

    Full Text Available Objectives: Marginal adaptation is important for long-term success of full-coverage restorations. The aim of this study was to determine the effect of porcelain firing cycle and different thicknesses of IPS e.max core on marginal accuracy of all-ceramic restorations.Materials and Methods: A standard stainless steel die with 0.8 mm classic chamfer finish line and 10° taper was used in this in vitro study. An impression was taken from the stainless steel die to fabricate 20 epoxy resin dies, which were then scanned and IPS e.max CAD cores were fabricated using computer-aided design/computer-aided manufacturing (CAD/CAM technique in two groups of 10 with  0.7 mm (group A and 0.4mm (group B core thickness. Copings were then placed on their respective dies and randomly numbered. The amount of marginal gap was measured in 10 points under a stereomicroscope (×90 magnification before and after porcelain veneering.Results: The mean gap in 0.7mm and 0.4mm core thicknesses was 15.62±2.55µm and 19.68±3.09µm before porcelain firing and 32.01±3.19µm and 35.24±3.8µm after porcelain firing. The difference in marginal gap between the two thicknesses was significant before porcelain firing but not significant after veneering. Significant differences were also found in the marginal gap before and after porcelain veneering in each group.Conclusion: The porcelain firing cycle increases marginal gap in IPS e.max CAD restorations; 0.3 mm decrease in core thickness slightly increased marginal discrepancy, however it was not significant.

  4. A GA-based PID active queue management control design for TCP/IP networks

    Science.gov (United States)

    Kuo, H.-H.; Chen, C.-K.; Yan, J.-J.; Liao, T.-L.

    2008-02-01

    In this paper, a genetic algorithm-based (GA-based) proportional-integral-derivative (PID) controller as an active queue manager for Internet routers is proposed to reduce packet loss and improve network utilization in TCP/IP networks. Based on the window-based nonlinear dynamics, the TCP network was modeled as a time-delayed system with a saturated input due to the limitations of packet-dropping probability and the effects of propagation delays in TCP networks. An improved genetic algorithm is employed to derive optimal or near optimal PID control gains such that a performance index of integrated-absolute error (IAE) in terms of the error between the router queue length and the desired queue length is minimized. The performance of the proposed control scheme was evaluated in various network scenarios via a series of numerical simulations. The simulation results confirm that the proposed scheme outperforms other AQM schemes.

  5. A FUZZY-LOGIC CONTROL ALGORITHM FOR ACTIVE QUEUE MANAGEMENT IN IP NETWORKS

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Active Queue Management (AQM) is an active research area in the Internet community. Random Early Detection (RED) is a typical AQM algorithm, but it is known that it is difficult to configure its parameters and its average queue length is closely related to the load level. This paper proposes an effective fuzzy congestion control algorithm based on fuzzy logic which uses the predominance of fuzzy logic to deal with uncertain events. The main advantage of this new congestion control algorithm is that it discards the packet dropping mechanism of RED, and calculates packet loss according to a preconfigured fuzzy logic by using the queue length and the buffer usage ratio. Theoretical analysis and Network Simulator (NS) simulation results show that the proposed algorithm achieves more throughput and more stable queue length than traditional schemes. It really improves a router's ability in network congestion control in IP network.

  6. QoS Management and Control for an All-IP WiMAX Network Architecture: Design, Implementation and Evaluation

    Directory of Open Access Journals (Sweden)

    Thomas Michael Bohnert

    2008-01-01

    Full Text Available The IEEE 802.16 standard provides a specification for a fixed and mobile broadband wireless access system, offering high data rate transmission of multimedia services with different Quality-of-Service (QoS requirements through the air interface. The WiMAX Forum, going beyond the air interface, defined an end-to-end WiMAX network architecture, based on an all-IP platform in order to complete the standards required for a commercial rollout of WiMAX as broadband wireless access solution. As the WiMAX network architecture is only a functional specification, this paper focuses on an innovative solution for an end-to-end WiMAX network architecture offering in compliance with the WiMAX Forum specification. To our best knowledge, this is the first WiMAX architecture built by a research consortium globally and was performed within the framework of the European IST project WEIRD (WiMAX Extension to Isolated Research Data networks. One of the principal features of our architecture is support for end-to-end QoS achieved by the integration of resource control in the WiMAX wireless link and the resource management in the wired domains in the network core. In this paper we present the architectural design of these QoS features in the overall WiMAX all-IP framework and their functional as well as performance evaluation. The presented results can safely be considered as unique and timely for any WiMAX system integrator.

  7. Achieving micelle control through core crystallinity.

    Science.gov (United States)

    Glavas, Lidija; Olsén, Peter; Odelius, Karin; Albertsson, Ann-Christine

    2013-11-11

    We have designed a pathway for controlling the critical micelle concentration and micelle size of polyester-based systems. This was achieved by creating an array of different copolymers with semicrystalline or amorphous hydrophobic blocks. The hydrophobic block was constructed through ring-opening polymerization of ε-caprolactone, L-lactide, and ε-decalactone, either as homopolymers or random copolymers, using PEG as both the initiator and the hydrophilic block. Micelles formed with amorphous cores exhibited considerably higher critical micelle concentrations than those with semicrystalline cores. Micelles with amorphous cores also became larger in size with an increased molecular weight of the hydrophobic bock, in contrast to micelles with semicrystalline cores, which displayed the opposite behavior. Hence, core crystallinity was found to be a potent tool for tailoring micelle properties and thereby facilitating the optimization of drug delivery systems. The introduction of PEG-PεDL also proved to be a valuable asset in the tuning of micelle properties.

  8. Smurf1 regulation of DAB2IP controls cell proliferation and migration

    Science.gov (United States)

    Wan, Lixin; Inuzuka, Hiroyuki; Sun, Liankun; North, Brian J.

    2016-01-01

    Tumor cell proliferation, survival and migration are regulated by the deletion of ovarian carcinoma 2/disabled homolog 2 (DOC-2/DAB2) interacting protein (DAB2IP), a tumor suppressor that serves as a scaffold protein for H-Ras and TRAF2. Importantly, the oncogenic histone methyl-transferase EZH2 epigenetically down-regulates DAB2IP in a variety of tumors. Recently, we demonstrated that DAB2IP is negatively regulated by Akt-dependent phosphorylation and SCFFbw7-mediated degradation. Here, we further identify the oncoprotein Smurf1, an E3-ubiquitin ligase, as a novel negative regulator of DAB2IP. Smurf1-mediated cellular proliferation and migration are largely dependent on the presence of DAB2IP, suggesting that DAB2IP is a key effector molecule of Smurf1 oncogenic function. Additionally, we identify that similar to DAB2IP, Smurf1 is also a target of phosphorylation by both Akt1 and Akt2 kinases, which enhances Smurf1 abundance, leading to a reduction in DAB2IP. Given the role of DAB2IP in tumorigenesis and metastasis, our data identify Smurf1 as an upstream oncogenic factor that negatively regulates DAB2IP to govern aberrant cell growth and migration. PMID:27036023

  9. Technology for Trusted IP Access Control Equipment%IP设备可信接入控制技术

    Institute of Scientific and Technical Information of China (English)

    葛晓滨; 许剑

    2011-01-01

    Trusted IP equipment proposed access control technology is proposed in this paper. The adoption of this technology can achieve a medium-sized enterprise information network for all IP devices in the management and control of access behavior. The system based on Linux system Python language to develop and management of end users in the Web interface through the IP visual resource planning, allocation, and can be used to develop a variety of IP strategy.The system realizes the information network for all IP devices on the access behavior of the control, in control, thus enhancing the security of information networks.%提出了IP设备可信接入控制技术.通过该技术的应用,实现了大中型企业信息网络中所有IP设备的接入行为的管理与控制,系统采用基于Linux系统的Python语言进行开发,用户在Web管理端通过可视化的界面进行IP资源的规划、分配,同时可以制定各种IP使用策略.系统实现了对信息网所有IP设备接入行为的可控、在控,从而提高了信息网络的安全性.

  10. A Feedback Control Mechanism of QoS Management for IP Telecommunication Network

    Institute of Scientific and Technical Information of China (English)

    CUI Yi-dong; JIAO Li; LIN Yu; WANG Wen-dong

    2005-01-01

    In this paper a feedback control mechanism of Quality of Service (QoS) management is proposed. By measuring and monitoring the operational information of the IP telecommunication network, the feedback control-loops tune the network according to the trends of the traffic characteristics in order to gain a favorable network status. With theoretical analysis, it is concluded that the QoS of an arbitrary k-class flow can be guaranteed when the capacity of the k-class traffic is not fully filled. Thus by distributing the bandwidth of the egress bottleneck link among the ingress links, the congestion can be relieved. Moreover, the capacity of each traffic class that shares the same link affects one another. Therefore, the feedback control also aims at adjusting the capacity proportion among the traffic classes. In order to realize the goals, three feedback control-loops are designed in the QoS management system. A CORBA-based implementation is deployed on the testbed.

  11. Strategies Towords Next Generation IP Over Optical Networks

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A consensus is emerging in industry on utilizing an IP-Centric control plane within optical networks to support dynamic provisioning and restoration of lightpaths. At the same time, there are divergent views of how IP routers interact with optical core networks to achieve end-to-end connectivity. This paper describes the strategies of optical communication's future development towards next generation IP over Optical Networks. The desirable extent of network transparency in advanced all-optical network architecture is studied. Architectural alternatives for interconnecting IP routers over optical networks, and the concerned routing and signaling issues are described.

  12. A Case Study on Ip Based Cdma Ran by Controlling Router

    Directory of Open Access Journals (Sweden)

    K Sravan Abhilash

    2014-08-01

    Full Text Available As communication plays an important role in day to day life, the effective and efficient data transmission is to be maintained. This paper mainly deals with implements a congestion control mechanism using Router control method for IP-RAN on CDMA cellular network. The Router control mechanism uses the features of CDMA networks using active Queue Management technique to reduce delay and to minimize the correlated losses. When utilizing these new personal tools and services to enrich our lives, while being mobile, we are using Mobile Multimedia applications. As new handsets, new technologies and new business models are introduced on the marketplace, new attractive multimedia services can and will be launched, fulfilling the demands. Because the number of multimedia services and even more so, the context in which the services are used is numerous, the following model is introduced in order to simplify and clarify how different services will evolve, enrich our lives and fulfill our desires.The proposed paper work is to be realized using Matlab platform.

  13. 基于IP核的数选式浮点矩阵相乘设计%Floating-point matrix multiplication design based on IP core

    Institute of Scientific and Technical Information of China (English)

    肖宇; 王建业; 张伟

    2011-01-01

    Based on the characteristics of a few selected matrix operations, matrix operations with gow-level IP cores, using the number of the IP core embedded in a matrix selection, while floating-point addition operation to add the method to achieve floating-point matrix multiplication. Saving resource consumption while improving system performance, and improved floating-point matrix operations in the FPGA. Simulation results show that the design is feasible, and it has some practical significance and applications.%本文根据数选式矩阵运算特点,结合低阶矩阵运算IP核,采用将IP核嵌入到数选矩阵中,同时添加浮点加法运算的方法,实现浮点矩阵相乘.在节省资源消耗的同时提升了系统性能,并将改进的浮点矩阵运算在FPGA中实现.仿真结果表明该设计可行,具有一定的实际意义和应用前景.

  14. Modernización del IP Backbone del Core de Voz para Telefónica Ecuador

    OpenAIRE

    Echeverria Medina, Jorge Leonardo

    2015-01-01

    En el mercado de las telecomunicaciones, la alta disponibilidad de las redes celulares hace muchos años atrás dejó de ser una meta y hoy en día es un requisito básico para cualquier operador. Siguiendo el continuo evolucionar de las empresas celulares consideradas grandes a nivel mundial, la compañía Telefónica Ecuador a mediados del año 2014 entró en un proceso de modernización de toda su red, modernización que incluyó el Backbone IP para su red de Voz a nivel nacional. Telefónica Ecuador cu...

  15. Dynamic Fuzzy Controlled RWA Algorithm for IP/GMPLS over WDM Networks

    Institute of Scientific and Technical Information of China (English)

    I-Shyan Hwang; I-Feng Huang; Shin-Cheng Yu

    2005-01-01

    This paper proposes a dynamic RWA scheme using fuzzy logic control on IP/GMPLS over WDM networks to achieve the best quality of network transmission. The proposed algorithm dynamically allocates network resources and reserves partial bandwidth based on the current network status, which includes the request bandwidth, average utilization for each wavelength and its coefficient of variance (C.V.) of data traffic, to determine whether the connection can be set up. Five fuzzy sets for request bandwidth, average rate and C.V. of data traffic are used to divide the variable space: very large (LP), large (SP), normal (ZE), small (SN), and very small (LN). Setting the fuzzy limit is a key part in the proposed algorithm. The simulation of scenarios in this paper has two steps. In the first step, the adaptive fuzzy limits are evaluated based on average transmission cost pertaining to ten network statuses. The second step is to compare the proposed algorithm with periodic measurement of traffic (PMT) in ATM networks in six network situations to show that the proposed FC-RWA algorithm can provide better network transmission.

  16. 参数化可配置IP核浮点运算器的设计与实现%Design and implementation of floating-point unit based on parameterized configurable IP core

    Institute of Scientific and Technical Information of China (English)

    刘竹松; 陈平华; 陈璟

    2011-01-01

    In this paper, parameterized IP core design method is introduced into the design of floating-point unit, through extracting usable parameters, the floating-point unit can be designed into a parameterized, configurable, reusable IP core. Finally,simulation verified the feasibility and effectiveness of floating-point unit as parameterized IP core.%将参数化可配置IP核的设计方法引入到浮点运算器设计中,通过设计时提取的可用参数,将浮点运算器设计成为参数化、可配置、可重用的IP核.通过仿真验证了实现参数化IP核浮点运算器的可行性和有效性.

  17. Global Command and Control System - Maritime (GCCS-M) Segments and SkyCAP Assured IP Software

    Science.gov (United States)

    2005-06-13

    UHF SATCOM JWID COWAN JWID 2004 SKYCAP/ EDSS /MEDAL Demonstration High-Level Operational Concept Graphic (OV-1) Simulated Remote Ground Station GCCS-M...providing IP connectivity to existing GCCS-M tactical decision aids using current tactical radio systems. – The SkyCAP/MEDAL/ EDSS combination demonstrated...SkyCAP Client Node SkyCAP Master Controller SkyCAP Client Node EODGRU ONE (Observer only – Optional participant) NSCT-1 • EDSS is an operational

  18. Effects of Light Source on the Color and Translucency of IPS e.max Press Core Ceramic%光源对IPS e.max(R)全瓷修复体颜色和半透明性的影响

    Institute of Scientific and Technical Information of China (English)

    李玲; 赵雯; 薛亮; 高婧; 孙翔; 邓再喜

    2013-01-01

    Objective:To evaluate the effect of the D65,A and F2 illuminant on the color and translucency of IPS e.max Press core ceramic.Methods:Specimens of IPS e.max Press MO1 core ceramic with different thicknesses were made.IPS e.max Ceram A2 was sintered on the core ceramic.The final thickness was controlled to 1.50 mm.The color parameters were measured with CM-700d Spectrophotometer.The translucency parameter and color difference (△E) between adjacent groups were calculated.Statistical analysis was done.Results:On the white background,based on all the specimens,the following results were obtained:L* values for A illuminant>F2 illuminant >D65 illuminant; a* values for A illuminant>D65 illuminant>F2 illuminant; b* values for F2 illuminant>A illuminant>D65 illuminant.With the increase of the ratio of core and dentine ceramic thickness,L* values for different illuminants increased,a* values,b* values and △E decreased.△E between different illuminants were as follows:A and D65 illuminant,4.15-4.89; F2 and D65 illuminant,2.87-3.55; F2 and A illuminant,4.63-5.53.Conclusion:Illuminant had a significant effect on the color and translucency of IPS e.max all-ceramic restoration.%目的:探讨D65 、A、F2光源下IPS e.max全瓷修复体的颜色和半透明性的影响.方法:制作不同厚度的IPS e.max Press MO1核瓷瓷片,在核瓷表面上堆塑IPS e.max Ceram A2牙本质瓷,使瓷试件最终厚度控制在1.50 mm.用CM-700d分光测色计分别测量各组试件不同光源下的颜色参数L*a*b*值,计算TP值和不同光源下的色差(△E),并对各组数据进行统计学分析.结果:在白背景下,各组试件的L*值在A光源下最大,其次是F2光源和D65光源,三者之间差异有统计学意义(P<0.01).a*值也是在A光源下最大,D65光源次之,最小是在F2光源下,三者之间有统计学差异(P<0.01).b*值变化为:F2光源>A光源>D65光源,三者之间差异有统计学意义(P<0.01).随着核瓷和牙本质瓷厚

  19. Design and Evaluation of IP Header Compression for Cellular-Controlled P2P Networks

    DEFF Research Database (Denmark)

    Madsen, T.K.; Zhang, Qi; Fitzek, F.H.P.

    2007-01-01

    In this paper we advocate to exploit terminal cooperation to stabilize IP communication using header compression. The terminal cooperation is based on direct communication between terminals using short range communication and simultaneously being connected to the cellular service access point....... The short range link is than used to provide first aid information to heal the decompressor state of the neighboring node in case of a packet loss on the cellular link. IP header compression schemes are used to increase the spectral and power efficiency loosing robustness of the communication compared...... to the uncompressed version. By introducing the terminal cooperation supporting header compression the robustness is increased. Within this article we will show that header compression should be applied to reduce the energy consumption of the terminals and moreover the header compression should be supported...

  20. Velocity-Controlled Magnetic Bearings with Solid Cores

    Science.gov (United States)

    Chen, H. Ming; Walton, James

    1996-01-01

    A methodology for designing velocity-controlled magnetic bearings with laminated cores has been extended to those with solid cores. The eddy-current effect of the solid cores is modeled as an opposing magnetomotive force. The bearing control dynamics is formulated in a dimensionless fashion which can be readily reviewed on a root-locus plot for stability. This facilitates the controller design and tuning process for solid core magnetic bearings using no displacement sensors.

  1. Protocol for the effect evaluation of Individual Placement and Support (IPS): a randomized controlled multicenter trial of IPS versus treatment as usual for patients with moderate to severe mental illness in Norway.

    Science.gov (United States)

    Sveinsdottir, Vigdis; Løvvik, Camilla; Fyhn, Tonje; Monstad, Karin; Ludvigsen, Kari; Øverland, Simon; Reme, Silje Endresen

    2014-11-18

    Roughly one third of disability pensions in Norway are issued for mental and behavioral disorders, and vocational rehabilitation offered to this group has traditionally been dominated by train-and-place approaches with assisted or sheltered employment. Based on a more innovative place-and-train approach, Individual Placement and Support (IPS) involves supported employment in real-life competitive work settings, and has shown great promise for patients with severe mental illness. The study is a multicenter Randomized Controlled Trial (RCT) of IPS in a Norwegian context, involving an effect evaluation, a process evaluation, and a cost/benefit analysis. IPS will be compared to high quality treatment as usual (TAU), with labor market participation and educational activity at 12 months post inclusion as the primary outcome. The primary outcome will be measured using register data, and the project will also include complete follow-up up to 4 years after inclusion for long-term outcome data. Secondary outcomes include mental health status, disability and quality of life, collected through survey questionnaires at baseline, and after 6 and 12 months. Participants will include patients undergoing treatment for moderate to severe mental illness who are either unemployed or on sickness or social benefits. The estimated total sample size of 400-500 will be randomly assigned to the interventions. To be eligible, participants must have an expressed desire to work, and sufficient Norwegian reading and writing skills to fill out the questionnaires. The Effect Evaluation of Individual Placement and Support (IPS) will be one of the largest randomized controlled trials to date investigating the effectiveness of IPS on competitive employment, and the first study to evaluate the effectiveness of IPS for patients with moderate to severe mental illness within a Norwegian context. Clinicaltrials.gov: NCT01964092 . Registered October 16th, 2013.

  2. Core flow control system for field applications; Sistema de controle de core-flow

    Energy Technology Data Exchange (ETDEWEB)

    Granzotto, Desiree G.; Adachi, Vanessa Y.; Bannwart, Antonio C.; Moura, Luiz F.M. [Universidade Estadual de Campinas (UNICAMP), SP (Brazil); Sassim, Natache S.D.A. [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Centro de Estudo do Petroleo (CEPETRO); Carvalho, Carlos H.M. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The significant heavy oil reserves worldwide and the presently high crude oil prices make it essential the development of technologies for heavy oil production and transportation. Heavy oils, with their inherent features of high viscosity (100- 10,000 cP) and density (below 20 deg API) require specific techniques to make it viable their flow in pipes at high flow rates. One of the simplest methods, which do not require use of heat or diluents, is provided by oil-water annular flow (core-flow). Among the still unsolved issues regarding core-flow is the two-phase flow control in order to avoid abrupt increases in the pressure drop due to the possible occurrence of bad water-lubricated points, and thus obtain a safe operation of the line at the lowest possible water-oil ratio. This work presents results of core flow tests which allow designing a control system for the inlet pressure of the line, by actuating on the water flow rate at a fixed oil flow rate. With the circuit model and the specified controller, simulations can be done to assess its performance. The experiments were run at core-flow circuit of LABPETRO-UNICAMP. (author)

  3. SEMICONDUCTOR INTEGRATED CIRCUITS A 10-bit 200-kS/s SAR ADC IP core for a touch screen SoC

    Science.gov (United States)

    Xingyuan, Tong; Yintang, Yang; Zhangming, Zhu; Wenfang, Sheng

    2010-10-01

    Based on a 5 MSBs (most-significant-bits)-plus-5 LSBs (least-significant-bits) C-R hybrid D/A conversion and low-offset pseudo-differential comparison approach, with capacitor array axially symmetric layout topology and resistor string low gradient mismatch placement method, an 8-channel 10-bit 200-kS/s SAR ADC (successive-approximation-register analog-to-digital converter) IP core for a touch screen SoC (system-on-chip) is implemented in a 0.18 μm 1P5M CMOS logic process. Design considerations for the touch screen SAR ADC are included. With a 1.8 V power supply, the DNL (differential non-linearity) and INL (integral non-linearity) of this converter are measured to be about 0.32 LSB and 0.81 LSB respectively. With an input frequency of 91 kHz at 200-kS/s sampling rate, the spurious-free dynamic range and effective-number-of-bits are measured to be 63.2 dB and 9.15 bits respectively, and the power is about 136 μW. This converter occupies an area of about 0.08 mm2. The design results show that it is very suitable for touch screen SoC applications.

  4. RapidIO IP核的验证方法研究%Verification Method Research for RapidIO IP Core

    Institute of Scientific and Technical Information of China (English)

    王玉欢; 田泽; 蔡叶芳

    2011-01-01

    串行RapidIO是针对高性能嵌入式系统芯片间和板间互连而设计的,是未来十几年中嵌入式系统互连的最佳选择之一.在以RapidIO为接口的SOC设计中,对RapidlO IP核的验证是其基础.基于对RapidIO协议的理解,研究了RapidlOIP核功能验证的方法、验证平台的搭建以及验证侧试过程的实施,提出了虚拟平台验证与FPGA原型验证相结合的验证方法.该验证过程搭建了可靠的验证平台,为RapidlO IP核的可靠工作提供了保证.文中的研究工作,从验证思路和方法上对于类似设计的验证具有一定的参考价值.%Serial RapidIO is designed for the connection among chips of high performance embedded system and that among boards. It is one of the best choices for the interconnection of embedded system in the future. In the SoC design with the RapidIO as its interface, verification for RapidIO core is the foundation. Based on the understanding of RapidIO protocol,take a research of the method of RapidIO core functional verification, the foundation of verification terrace and the implementation of the verification test process, raised the verification method that combined the virtual terrace verification and FPGA archetype verification. This verification process found a dependable verification testbench, guaranteeing the dependable work of RapidIO IP core. For sinilar designed verification, research in this essay has some reference value in mentality and method field of verification.

  5. IP and Competitiveness of Chinese Telecom Firms

    Institute of Scientific and Technical Information of China (English)

    ZENG Jian-qiu

    2004-01-01

    Based on the influence, this paper discusses the perspectives of IP technology. It illustrates that IP is changing the service structure of China Telecom and IP is striking traditional telecom networks and changing the competitive structure of telecom markets. IP is one of core technologies in future telecom networks and there is an opportunity for Chinese telecom firms to quicken their network innovation and improve the competitiveness for their sustainable development.

  6. Controlled Release of Ciprofloxacin from Core-Shell Nanofibers with Monolithic or Blended Core.

    Science.gov (United States)

    Zupančič, Špela; Sinha-Ray, Sumit; Sinha-Ray, Suman; Kristl, Julijana; Yarin, Alexander L

    2016-04-04

    Sustained controlled drug release is one of the prominent contributions for more successful treatment outcomes in the case of several diseases. However, the incorporation of hydrophilic drugs into nanofibers, a promising novel delivery system, and achieving a long-term sustained release still pose a challenging task. In this work we demonstrated a robust method of avoiding burst release of drugs and achieving a sustained drug release from 2 to 4 weeks using core-shell nanofibers with poly(methyl methacrylate) (PMMA) shell and monolithic poly(vinyl alcohol) (PVA) core or a novel type of core-shell nanofibers with blended (PVA and PMMA) core loaded with ciprofloxacin hydrochloride (CIP). It is also shown that, for core-shell nanofibers with monolithic core, drug release can be manipulated by varying flow rate of the core PVA solution, whereas for core-shell nanofibers with blended core, drug release can be manipulated by varying the ratios between PMMA and PVA in the core. During coaxial electrospinning, when the solvent from the core evaporates in concert with the solvent from the shell, the interconnected pores spanning the core and the shell are formed. The release process is found to be desorption-limited and agrees with the two-stage desorption model. Ciprofloxacin-loaded nanofiber mats developed in the present work could be potentially used as local drug delivery systems for treatment of several medical conditions, including periodontal disease and skin, bone, and joint infections.

  7. Apparatus for controlling molten core debris. [LMFBR

    Science.gov (United States)

    Golden, M.P.; Tilbrook, R.W.; Heylmun, N.F.

    1977-07-19

    Disclosed is an apparatus for containing, cooling, diluting, dispersing and maintaining subcritical the molten core debris assumed to melt through the bottom of a nuclear reactor pressure vessel in the unlikely event of a core meltdown. The apparatus is basically a sacrificial bed system which includes an inverted conical funnel, a core debris receptacle including a spherical dome, a spherically layered bed of primarily magnesia bricks, a cooling system of zig-zag piping in graphite blocks about and below the bed and a cylindrical liner surrounding the graphite blocks including a steel shell surrounded by firebrick. Tantalum absorber rods are used in the receptacle and bed. 9 claims, 22 figures.

  8. Running TCP/IP over ATM Networks.

    Science.gov (United States)

    Witt, Michael

    1995-01-01

    Discusses Internet protocol (IP) and subnets and describes how IP may operate over asynchronous transfer mode (ATM). Topics include TCP (transmission control protocol), ATM cells and adaptation layers, a basic architectural model for IP over ATM, address resolution, mapping IP to a subnet technology, and connection management strategy. (LRW)

  9. NGS-QC Generator: A Quality Control System for ChIP-Seq and Related Deep Sequencing-Generated Datasets.

    Science.gov (United States)

    Mendoza-Parra, Marco Antonio; Saleem, Mohamed-Ashick M; Blum, Matthias; Cholley, Pierre-Etienne; Gronemeyer, Hinrich

    2016-01-01

    The combination of massive parallel sequencing with a variety of modern DNA/RNA enrichment technologies provides means for interrogating functional protein-genome interactions (ChIP-seq), genome-wide transcriptional activity (RNA-seq; GRO-seq), chromatin accessibility (DNase-seq, FAIRE-seq, MNase-seq), and more recently the three-dimensional organization of chromatin (Hi-C, ChIA-PET). In systems biology-based approaches several of these readouts are generally cumulated with the aim of describing living systems through a reconstitution of the genome-regulatory functions. However, an issue that is often underestimated is that conclusions drawn from such multidimensional analyses of NGS-derived datasets critically depend on the quality of the compared datasets. To address this problem, we have developed the NGS-QC Generator, a quality control system that infers quality descriptors for any kind of ChIP-sequencing and related datasets. In this chapter we provide a detailed protocol for (1) assessing quality descriptors with the NGS-QC Generator; (2) to interpret the generated reports; and (3) to explore the database of QC indicators (www.ngs-qc.org) for >21,000 publicly available datasets.

  10. Core-shell microparticles for protein sequestration and controlled release of a protein-laden core.

    Science.gov (United States)

    Rinker, Torri E; Philbrick, Brandon D; Temenoff, Johnna S

    2016-12-21

    Development of multifunctional biomaterials that sequester, isolate, and redeliver cell-secreted proteins at a specific timepoint may be required to achieve the level of temporal control needed to more fully regulate tissue regeneration and repair. In response, we fabricated core-shell heparin-poly(ethylene-glycol) (PEG) microparticles (MPs) with a degradable PEG-based shell that can temporally control delivery of protein-laden heparin MPs. Core-shell MPs were fabricated via a re-emulsification technique and the number of heparin MPs per PEG-based shell could be tuned by varying the mass of heparin MPs in the precursor PEG phase. When heparin MPs were loaded with bone morphogenetic protein-2 (BMP-2) and then encapsulated into core-shell MPs, degradable core-shell MPs initiated similar C2C12 cell alkaline phosphatase (ALP) activity as the soluble control, while non-degradable core-shell MPs initiated a significantly lower response (85+19% vs. 9.0+4.8% of the soluble control, respectively). Similarly, when degradable core-shell MPs were formed and then loaded with BMP-2, they induced a ∼7-fold higher C2C12 ALP activity than the soluble control. As C2C12 ALP activity was enhanced by BMP-2, these studies indicated that degradable core-shell MPs were able to deliver a bioactive, BMP-2-laden heparin MP core. Overall, these dynamic core-shell MPs have the potential to sequester, isolate, and then redeliver proteins attached to a heparin core to initiate a cell response, which could be of great benefit to tissue regeneration applications requiring tight temporal control over protein presentation.

  11. Quality incentive based congestion control for multimedia communication over IP networks

    Institute of Scientific and Technical Information of China (English)

    JOHANSEN Stian; KIM Anna N.; PERKIS Andrew

    2006-01-01

    In this paper we introduce a framework for using quality as an incentive to promote proper application level congestion control. Through integrating a joint-source channel coder and feedback-based congestion control scheme, we are able to construct accurate and efficient quality incentives. The framework is applicable in all network architectures where end-to-end congestion control may be used, and is as such not specific to either best-effort or traffic class-based architectures. The concept is presented along with preliminary simulations that highlight the resulting rate control accuracy. We also discuss how to implement some well-known congestion control schemes within our framework.

  12. Connecting core percolation and controllability of complex networks.

    Science.gov (United States)

    Jia, Tao; Pósfai, Márton

    2014-06-20

    Core percolation is a fundamental structural transition in complex networks related to a wide range of important problems. Recent advances have provided us an analytical framework of core percolation in uncorrelated random networks with arbitrary degree distributions. Here we apply the tools in analysis of network controllability. We confirm analytically that the emergence of the bifurcation in control coincides with the formation of the core and the structure of the core determines the control mode of the network. We also derive the analytical expression related to the controllability robustness by extending the deduction in core percolation. These findings help us better understand the interesting interplay between the structural and dynamical properties of complex networks.

  13. A geophysical analysis of hydro-geomorphic controls within a headwater wetland in a granitic landscape, through ERI and IP

    Directory of Open Access Journals (Sweden)

    E. S. Riddell

    2010-08-01

    Full Text Available Wetlands are undergoing considerable degradation in South Africa. As interventions are often technical and costly, there is a requirement to develop conceptual process models for these wetland systems so that rehabilitation attempts will be successful. This paper presents an approach using the geophysical methods of Electrical Resistivity Imaging (ERI and Induced Polarization (IP to delineate sub-surface hydro-geomorphic controls that maintain equilibrium disconnectivity of wetland-catchment processes, which through gully erosion are increasing the catchments connectivity through loss of water and sediment. The findings presented here give insight into the geomorphic processes that maintain the wetland in an un-degraded state, this allows for the development of a conceptual model outlining the wetland forming processes. The analysis suggests that sub-surface clay-plugs, within an otherwise sandy substrate are created by illuviation of clays from the surrounding hillslopes particularly at zones of valley confinement.

  14. End to end adaptive congestion control in TCP/IP networks

    CERN Document Server

    Houmkozlis, Christos N

    2012-01-01

    This book provides an adaptive control theory perspective on designing congestion controls for packet-switching networks. Relevant to a wide range of disciplines and industries, including the music industry, computers, image trading, and virtual groups, the text extensively discusses source oriented, or end to end, congestion control algorithms. The book empowers readers with clear understanding of the characteristics of packet-switching networks and their effects on system stability and performance. It provides schemes capable of controlling congestion and fairness and presents real-world app

  15. Predictive functional control for active queue management in congested TCP/IP networks.

    Science.gov (United States)

    Bigdeli, N; Haeri, M

    2009-01-01

    Predictive functional control (PFC) as a new active queue management (AQM) method in dynamic TCP networks supporting explicit congestion notification (ECN) is proposed. The ability of the controller in handling system delay along with its simplicity and low computational load makes PFC a privileged AQM method in the high speed networks. Besides, considering the disturbance term (which represents model/process mismatches, external disturbances, and existing noise) in the control formulation adds some level of robustness into the PFC-AQM controller. This is an important and desired property in the control of dynamically-varying computer networks. In this paper, the controller is designed based on a small signal linearized fluid-flow model of the TCP/AQM networks. Then, closed-loop transfer function representation of the system is derived to analyze the robustness with respect to the network and controller parameters. The analytical as well as the packet-level ns-2 simulation results show the out-performance of the developed controller for both queue regulation and resource utilization. Fast response, low queue fluctuations (and consequently low delay jitter), high link utilization, good disturbance rejection, scalability, and low packet marking probability are other features of the developed method with respect to other well-known AQM methods such as RED, PI, and REM which are also simulated for comparison.

  16. Multiple MIPS 4Kc cores based interrupt controller design and its implementation on HDTV SoC platform

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A multiple MIPS 4Kc processor cores based interrupt processing system is introduced. The interrupt controller plays a key role in the high definition television (HDTV) system-on-a-chip (SoC) platform,especially when it is a multiple processor system. Based on a general introduction to the whole HDTV SoC platform, a layered interrupt controller and its implementation are discussed in detail. The proposed scheme was implemented in our FPGA verification board. The results indicate that our scheme is reliable and efficient. Meanwhile, as a functional intellectual property (IP), the interrupt controller has reusability and expandability with the layered structure.

  17. TCP/IP foundations

    CERN Document Server

    Blank, Andrew G

    2006-01-01

    The world of IT is always evolving, but in every area there are stable, core concepts that anyone just setting out needed to know last year, needs to know this year, and will still need to know next year. The purpose of the Foundations series is to identify these concepts and present them in a way that gives you the strongest possible starting point, no matter what your endeavor. TCP/IP Foundations provides essential knowledge about the two protocols that form the basis for the Internet, as well as many other networks. What you learn here will benefit you in the short term, as you acquire and

  18. Voice over Internet Protocol (VoIP) Technology as a Global Learning Tool: Information Systems Success and Control Belief Perspectives

    Science.gov (United States)

    Chen, Charlie C.; Vannoy, Sandra

    2013-01-01

    Voice over Internet Protocol- (VoIP) enabled online learning service providers struggling with high attrition rates and low customer loyalty issues despite VoIP's high degree of system fit for online global learning applications. Effective solutions to this prevalent problem rely on the understanding of system quality, information quality, and…

  19. Infinite Queue Management via Cascade Control for Industrial Routers in Smart Grid IP Networks

    Directory of Open Access Journals (Sweden)

    Ku-Hwan Kim

    2016-01-01

    Full Text Available Smart grid applications experience an extremely wide range of communication delay. Data flows of those applications are normally aggregated at industrial network routers in substations, form infinite (long queues termed bufferbloat issue, and might damage the operation of transmission control protocol. The default queue management scheme, DropTail, in such routers just drops packets if queue is full while the others in literature are mostly based on one-loop feedback control where an optimal point of performance between queue length and drop rate is limited. In this paper, we study the problem of managing a long queue of industrial router at substation under heterogeneous smart grid networks. Specifically, we propose an enqueue-dequeue dropping cascade control using a two-loop design method to control both window size and queue length. Moreover, our proposal can be easily implemented into router firmware with provided discrete expressions. Finally, our simulation results are presented to validate the possible benefits that can be gained from cascade control and compare the existing queue management methods as well.

  20. Investigation on TCP/IP Congestion Control in Optical Burst Switched (OBS Network

    Directory of Open Access Journals (Sweden)

    Ms. Payal Daryani

    2012-03-01

    Full Text Available Transport Control Protocol (TCP is the dominant protocol in modern communication networks, in which the issues of reliability, flow, and congestion control must be handled efficiently. In this review paper an analytical switching is used to exploit the huge bandwidth of optical fibers for future high speed internet backbone. It carries multiple packets, in their turn. Different aggregation schemes have been considered and evaluated.TCP performance greatly depends on the TCP congestion window behavior that is related to loss events occurring in the optical burst switched network, there is a special term called traffic shaping by which we control over the network according to the network load .that means we increase or decrease the send rate according to the network demand.

  1. Dynamic traffic grooming in distributed-controlled IP/WDM optical mesh networks

    Institute of Scientific and Technical Information of China (English)

    Huang Jun; Zeng Qingji; Liu Jimin; Xiao Pengcheng; Liu Hua; Xiao Shilin

    2005-01-01

    In this paper, the study was devoted to the traffic-grooming problem in a distributed-controlled WDM mesh network. We studied the optimization of the maximal number of ports configured at each node in the network. We gave the maximumnumber simulation results in different network environment, which could be taken as a reference for network design.

  2. GMPLS: IP-Centric Control Protocols for Optical Networks(Tutorial)

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Recent advances in optical networking technologies, particularly DWDM and MEMS, promise the transmission and switching of huge bandwidth capacity. The carriers have convinced of that their revenue must be earned from efficient bandwidth management instead of unsophisticated increase in capacity. The distributed control plane can offer more flexibility, reliability and scalability, whose functions include addressing, resource and topology discovery, route computation, provisioning and restoration. Genera...

  3. Introduction to IP address management

    CERN Document Server

    Rooney, Tim

    2010-01-01

    "The book begins with a basic overview of IP networking, followed by chapters describing each of the three core IPAM technologies: IPv4 and IPv6 addressing, DHCP, and DNS. The next three chapters describe IPAM management techniques and practice, followed by chapters on IPv4-IPv6 co-existence, security and the IPAM business case"--

  4. Comparison of different microprocessor controlled knee joints on the energy consumption during walking in trans-femoral amputees: intelligent knee prosthesis (IP) versus C-leg.

    Science.gov (United States)

    Chin, Takaaki; Machida, Katsuhiro; Sawamura, Seishi; Shiba, Ryouichi; Oyabu, Hiroko; Nagakura, Yuji; Takase, Izumi; Nakagawa, Akio

    2006-04-01

    The purpose of this study was to investigate the characteristic differences between the IP and C-Leg by making a comparative study of energy consumption and walking speeds in trans-femoral amputees. The subjects consisted of four persons with traumatic trans-femoral amputations aged 17 - 33 years who had been using the IP and were active in society. Fourteen able-bodied persons served as controls. First the energy consumption at walking speeds of 30, 50, 70, and 90 m/min was measured when using the IP. Then the knee joint was switched to the C-Leg. The same energy consumption measurement was taken once the subjects were accustomed to using the C-Leg. The most metabolically efficient walking speed was also determined. At a walking speed of 30 m/min using the IP and C-Leg, the oxygen rate (ml/kg/ min) was, on average, 42.5% and 33.3% higher (Pmicroprocessor controlled knee joints appeared to be valid alternative for improving walking performance of trans-femoral amputees.

  5. Subnanometer Control of Mean Core Size during Mesofluidic Synthesis of Small (D(core) Nanoparticles.

    Science.gov (United States)

    Elliott, Edward W; Haben, Patrick M; Hutchison, James E

    2015-11-03

    A convenient, single-step synthesis is reported that produces ligand-stabilized, water-soluble gold nanoparticles (AuNPs) with subnanometer-level precision of the mean core diameter over a range of 2-9 nm for a series of desired surface chemistries. The synthesis involves the reduction of a Au(III) species with sodium borohydride in the presence of a functionalized alkyl thiosulfate (Bunte salt) to yield thiolate-protected AuNPs. A key advantage of this synthesis is that simply adjusting the pH of the gold salt solution leads to control over the AuNP core size. The speciation of Au(III), and therefore the kinetics for its reduction and the core size produced, depends upon pH. The use of pH as the sole variable to control core size is a more reliable and convenient method than traditional approaches that rely on adjusting the concentrations and ratios of ligand, metal salt, and reducing agent. The average core size increased as the pH was raised for each ligand studied. Because the influence of pH was different for each of the ligands, working curves were plotted for each ligand to identify conditions to synthesize particles with specific, targeted core diameters. Using this approach, reaction conditions can be rapidly optimized using a combination of a mesofluidic reactor and small-angle X-ray scattering (SAXS) size analysis. The use of the mesofluidic reactor was needed to ensure fast mixing given the rapid kinetics for core formation. Using the reactor, it is possible to obtain reproducible sizes across multiple syntheses (size variation) and subnanometer control of the mean core dimensions. The synthetic method demonstrated here provides an attractive alternative to two-step syntheses involving ligand exchange because it is more efficient and eliminates the possibility of nanoparticle core size changes during exchange steps. This approach enables the development of "size ladders" of particles with the same surface chemistry for investigations of structure

  6. Can the mantle control the core?: Energetics and dynamics

    Science.gov (United States)

    Nakagawa, T.

    2011-12-01

    The sustainability of magnetic field generation is discussed from a coupled model of numerical mantle convection simulation and core energetics theory. The pattern of geomagnetic field could be also controlled as a consequence of mantle convection [e.g. Amit and Choblet, 2009]. Our previous studies have suggested that the best-fit scenario for explaining both sustainability of magnetic field generation caused by dynamo actions and the size of inner core would be strongly controlled by the heat transfer of mantle convection with strongly compositional heterogeneities [Nakagawa and Tackley, 2004; Nakagawa and Tackley, 2010]. Here we investigate effects of initial mantle temperature and radioactive heat source in a convecting mantle with extremely high initial temperature at the core-mantle boundary that has been suggested from the hypothesis of early Earth [Labrosse et al., 2007] for checking how the mantle can control the thermal evolution of the core. Main consequence is that the amount of heat production rate and initial mantle temperature are not very sensitive to the thermal evolution of Earth's core but the convective vigor seems to be sensitive to the results. For the mantle side, the Urey ratio is not very good constraint for understanding thermal evolution of the whole Earth. In addition, we also show an example of numerical dynamo simulations with both a stably stratified layer and lateral variation of heat flux across the core-mantle boundary (CMB), which expands a paper by Nakagawa [2011], evaluated from numerical mantle convection simulations for checking how the mantle can control the dynamics of the core, which checks dead or alive for the magnetic field generated by dynamo actions with strongly lateral variation of CMB heat flux.

  7. A、B色系IPS E.max LT底层材料色度值和相对透明率测定%Relative translucency and chromatic value test of A and B color series IPS E.max LT core materials

    Institute of Scientific and Technical Information of China (English)

    邵龙泉; 孙挺; 伊元夫; 邓斌; 温宁; 刘琦

    2011-01-01

    目的:测定A、B色系IPS E.max LT底层材料的CIE-1976-L* a* b*色度值和相对透明率.方法:制作直径为13mm、厚度为0.3 mm和0.5 mm的A、B色系盘状IPS E.max LT试件,色号包括A1、A2、A3、A3.5、A4、B1、B2、B3、B4,共计18组(n=5),应用CM-5分光测色计测试试件在标准黑、白背景下的表面光反射率Y值,记录Yb、Yw平均值,计算相对透明率(Yb/Yw);测试A、B色系瓷锭的色度值.结果:同一色系内,各组瓷锭明度值的总体均数不相等,组间差异具有显著性(P<0.01).从A1到A4、B1到B4,明度值均逐渐减低.相同厚度、相同色系的试件组间相对透明率差异无显著性(P>0.05),相对透明率数值分布范围为0.330 9~0.5875.相同色号、不同厚度的2组试件组间差异均具有显著性,0.3 mm组底层材料的相对透明率小于0.5 mm组(P<0.05).结论:厚度是A、B色系IPS E.max LT底层材料相对透明率的重要相关因素.%Objective: To study the relative translucency and chromatic value of IPS E. Max A and B color series core materials. Methods: Cylindrical core materials dentine porcelain specimen disks with diameter of 13.0 mm, thickness of 0.3 mm or 0.5 mm were respectively made(ra=5). The reflectivity value(Yb and Yw) of all samples was determined with CM-5 chromatism instrument, and the relative translucency(Yb/Yw) was calculated. The chromatic value of ceramic ingots provided by the manufacturer was measuredtoo. Results: L * of ceramic ingots was significantly different among specimen groups of A or B color series( P <0.01). From Al to A4 and from B1 to B4, L * declined. There was no significant different among specimen groups which had same thickness and belonged to same color series. The range of relative translucency was between 0. 330 9 and 0.587 5. Significant difference was found between specimen groups which had different thickness and same color number( P < 0.05 ). Conclusion: Thickness is an important factor of translucency for

  8. ChIP-seq and RNA-seq methods to study circadian control of transcription in mammals

    Science.gov (United States)

    Takahashi, Joseph S.; Kumar, Vivek; Nakashe, Prachi; Koike, Nobuya; Huang, Hung-Chung; Green, Carla B.; Kim, Tae-Kyung

    2015-01-01

    Genome-wide analyses have revolutionized our ability to study the transcriptional regulation of circadian rhythms. The advent of next-generation sequencing methods has facilitated the use of two such technologies, ChIP-seq and RNA-seq. In this chapter, we describe detailed methods and protocols for these two techniques, with emphasis on their usage in circadian rhythm experiments in the mouse liver, a major target organ of the circadian clock system. Critical factors for these methods are highlighted and issues arising with time series samples for ChIP-seq and RNA-seq are discussed. Finally detailed protocols for library preparation suitable for Illumina sequencing platforms are presented. PMID:25662462

  9. Mobile IP: Security & application

    NARCIS (Netherlands)

    Tuquerres, Gloria; Salvador, Marcos Rogério; Sprenkels, Ron

    1999-01-01

    As required in the TGS Mobile IP Advanced Module, this paper presents a survey of common security threats which mobile IP networks are exposed to as well as some proposed solutions to deal with such threats.

  10. TCP/IP Network In Process Control Plants%过程控制中的TCP/IP网络

    Institute of Scientific and Technical Information of China (English)

    牟连佳; 王立明

    2002-01-01

    提出TCP/IP在过程控制中的应用. 评价TCP/IP控制系统性能,通过传统控制系统与TCP/IP控制系统的比较,指出采用TCP/IP 控制系统的优缺点. 说明过程控制技术中,采用TCP/IP是一种更好的选择.

  11. Ensuring Software IP Cleanliness

    Directory of Open Access Journals (Sweden)

    Mahshad Koohgoli

    2007-12-01

    Full Text Available At many points in the life of a software enterprise, determination of intellectual property (IP cleanliness becomes critical. The value of an enterprise that develops and sells software may depend on how clean the software is from the IP perspective. This article examines various methods of ensuring software IP cleanliness and discusses some of the benefits and shortcomings of current solutions.

  12. Evaluation of IP Portfolios

    DEFF Research Database (Denmark)

    Søberg, Peder Veng

    2009-01-01

    As a result of an inquiry concerning how to evaluate IP (intellectual property) portfolios in order to enable the best possible use of IP resources within organizations, an IP evaluation approach primarily applicable for patents and utility models is developed. The developed approach is useful...

  13. A GA-BASED SYSTEM-ON-CHIP IP CORE MAPPING METHOD%基于遗传算法的片上系统IP核映射方法

    Institute of Scientific and Technical Information of China (English)

    赖国明

    2011-01-01

    片上系统SoC是指在单个芯片上集成了专用处理器、通用处理器、DSP、共享内存块、专用内存块、I/O部件等多个IP核的复杂的系统.规则拓扑的Mesh网格具有布线工整等优点,利用Mesh网格可以很方便地实现复杂的片上系统SoC.知识产权核(Intellectual Property Cores,IP核)到Mesh格件的映射问题是SOC设计的关键问题之一,其本质上是一种二次分配问题的NP难问题,目前没有多项式时间的求优方法.而遗传算法能够有效地求解问题的近似最优解.提出一种基于遗传的映射算法能够在几分钟内求得最小通信能耗的映射.%System-on-Chip (SoC) is a complex system that integrates functional processors, general processors, DSPs, shared memory, private memory, I/O components as well as other IP cores. Regular topological mesh grid has such merits as neat wiring. It is convenient to fulfill complicated SoCs by utilizing mesh. The problem of mapping intellectual property cores (IP cores) to mesh tiles is one of the key issues of SoC design. Mapping problem, naturally a quadratic assignment problem, is known as NP hard problem, which, currently, cannot be solved within polynomial time to achieve an optimal solution. However genetic algorithm (GA) is suitable for solving an approximate solution for such kind of problem. This article proposes a GA-based mapping method that can minimize communication energy consumption within a few minutes for achieving mapping.

  14. Apparatus and method for controlling the temperature of the core of a super-conducting transformer

    Science.gov (United States)

    Golner, Thomas; Pleva, Edward; Mehta, Shirish

    2006-10-10

    An apparatus for controlling the temperature of a core of a transformer is provided that includes a core, a shield surrounding the core, a cast formed between the core and the shield, and tubing positioned on the shield. The cast directs heat from the core to the shield and cooling fluid is directed through the tubing to cool the shield.

  15. STUDY THE EFFECTIVENESS APPLICATIONS OF FUZZY CONTROLLER WITH TWO ENTRANCES IN THE SYSTEM OF ACTIVE QUEUE MANAGEMENT THE PACKETS IN TCP/IP NETWORKS

    Directory of Open Access Journals (Sweden)

    O. V. Nevdachyna

    2016-01-01

    Full Text Available The paper presents an approach to solving the overloading problem in TCP/IP networks. Offered fuzzy controller with two inputs for system of active queue management packages in TCP/IP networks, and investigated its use in these systems with a random change of traffic load. Proposed controller has two inputs, one of which is the value of the difference between the current queue length and the second – the difference between the current level of usage of the buffer. The output of the fuzzy controller calculates the probability of discarding packet.Mathematical model system of active queue management that is studied is presented in an interactive MATLAB system, in wherein also is demonstrated the processes occurring in the system with a random change of traffic load. The research results show that the AQM-system with fuzzy controller with two entrances stable enough maintains the desired current length the queue for sufficiently small values of the probability of dropping/marking packets (at acceptable size of queue q0= 200 packets, the average probability of dropping / marking is not more than 3,5×10–3 or less 0,35% packets is discarded or marked from the total number of incoming packets. The results obtained will help improve the efficiency of the functioning and operation of TCP / IP networks by increasing data transmission quality. this happens due introduction of the proposed controller at the design of new, more efficient routers for networks to minimize the delay of information.

  16. Extending the Scope of the Resource Admission Control Subsystem (RACS) in IP multimedia subsystem using cognitive radios

    CSIR Research Space (South Africa)

    Muwonge, BK

    2008-04-01

    Full Text Available .K. Kalebaila, A.H. Chan, “Advanced Mobility Support in Next- Generation All-IP Wireless Networks: A Cross-Layer Approach - Part I”, Personal, Indoor and Mobile Radio Communications, 2006 IEEE 17th International Symposium. [4] Theodor J Stewart “Decision...-Layer API for Unified Media Access). Information Society Technologies. [9] Christian James Rieser, “Biologically Inspired Cognitive Radio Engine Model Utilizing [10] N. Baldo, N. Baldo, and M. Zorzi, "Fuzzy Logic for Cross-layer Optimization...

  17. Control Rod Reactivity Curves for the Annular Core Research Reactor

    Science.gov (United States)

    Depriest, K. Russell; Kajder, Karen C.; Frye, Jason N.; Denman, Matthew R.

    2009-08-01

    Experiments were conducted at the Annular Core Research Reactor (ACRR) to increase the fidelity of the control rod integral reactivity worth curve. This experiment series was designed to refine the integral reactivity curve used for pulse yield prediction and eliminate the need for operator compensation in the pulse setup. The experiment series consisted of delayed critical and positive period measurements with various ACRR cavity configurations. An improved integral reactivity worth curve for the ACRR control rods has been constructed using the positive period measurements, the delayed critical measurements, and radiation transport modeling of the reactor. A series of prompt period measurements is used to validate that the new control rod curve more accurately predicts the energy yield of the pulse operations. The new reactivity worth curve is compared with the current curve that was developed using traditional approaches.

  18. Implementasi Sistem IP PBX menggunakan Briker

    Directory of Open Access Journals (Sweden)

    DWI ARYANTA

    2017-06-01

    Full Text Available Abstrak VoIP (Voice over Internet Protocol adalah komunikasi suara jarak jauh yang digunakan melalui jaringan IP. Pada penelitian ini dirancang sistem IP PBX dengan menggunakan teknologi berbasis VoIP. IP PBX adalah perangkat switching komunikasi telepon dan data berbasis teknologi Internet Protocol (IP yang mengendalikan ekstension telepon analog maupun ekstension IP Phone. Software VirtualBox digunakan dengan tujuan agar lebih memudahkan dalam sistem pengoperasian Linux yang dimana program untuk membuat IP PBX adalah menggunakan Briker yang bekerja pada Operating System Linux 2.6. Setelah proses penginstalan Briker pada Virtualbox dilakukan implementasi jaringan IP PBX. Setelah mengimplementasikan jaringan IP PBX sesuai dengan topologi, kemudian melakukan pengujian success call rate dan analisis Quality of Service (QoS. Pengukuran QoS menggunakan parameter jitter, delay, dan packet loss yang dihasilkan dalam sistem IP PBX ini. Nilai jitter sesama user Briker (baik pada smartphone maupun komputer mempunyai rata-rata berada pada nilai 16,77 ms. Sedangkan nilai packetloss yang didapat pada saat terdapat pada saat user 1 sebagai pemanggil telepon adalah 0%. Sedangkan persentase packet loss pada saat user 1 sebagai penerima telepon adalah 0,01%. Nilai delay pada saat berkomunikasi antar user berada pada 11,75 ms. Secara keseluruhan nilai yang didapatkan melalui penelitian ini, dimana hasil pengujian parameter-parameter QOS sesuai dengan standar yang telah direkomendasikan oleh ITU dan didapatkan nilai QoS dengan hasil “baik”. Kata Kunci : Briker, VoIP, QoS, IP PBX, Smartphone. Abstract VoIP (Voice over Internet Protocol is a long-distance voice communications over IP networks are used. In this study, IP PBX systems designed using VoIP -based technologies. IP PBX is a telephone switching device and data communication technology-based Internet Protocol (IP which controls the analog phone extensions and IP Phone extensions. VirtualBox software is

  19. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  20. CORE

    DEFF Research Database (Denmark)

    Krigslund, Jeppe; Hansen, Jonas; Hundebøll, Martin

    2013-01-01

    different flows. Instead of maintaining these approaches separate, we propose a protocol (CORE) that brings together these coding mechanisms. Our protocol uses random linear network coding (RLNC) for intra- session coding but allows nodes in the network to setup inter- session coding regions where flows...... intersect. Routes for unicast sessions are agnostic to other sessions and setup beforehand, CORE will then discover and exploit intersecting routes. Our approach allows the inter-session regions to leverage RLNC to compensate for losses or failures in the overhearing or transmitting process. Thus, we...... increase the benefits of XORing by exploiting the underlying RLNC structure of individual flows. This goes beyond providing additional reliability to each individual session and beyond exploiting coding opportunistically. Our numerical results show that CORE outperforms both forwarding and COPE...

  1. Light element controlled iron isotope fractionation in planetary cores

    Science.gov (United States)

    Shahar, A.; Hillgren, V. J.; Horan, M. F.; Duke, L.; Mock, T. D.

    2013-12-01

    Using iron isotope fractionations measured in planetary and meteorite samples to trace planetary differentiation or formation has yielded contradictory results. Iron from high-Ti lunar basalts is more enriched in 57Fe/54Fe than mantle-derived terrestrial samples, in contrast to the isotopic similarity for almost every other element between the Earth and Moon. SNC (Shergottite, Nakhlite, Chassigny) and HED (Howardite, Eucrite, Diogenite) meteorites, which are thought to be derived from the mantles of Mars and Vesta, respectively, show no isotopic fractionation relative to chondrites. While the Bulk Silicate Earth (BSE) value is debated, recent work has shown effectively that basalts (mid-ocean ridge basalts, terrestrial basalts, and ocean island basalts) are enriched in 57Fe/54Fe relative to chondrites, but the causes of that fractionation are unclear (Craddock et al. 2013). Angrites, basaltic achondrite meteorites, also show enrichment in δ57Fe (Wang et al. 2012). Possible mechanisms include high-pressure core formation, oxidation during perovskite disproportionation, evaporation during the giant impact, and mantle melting. It is important to reconcile why the Earth's basalts are enriched in 57Fe/54Fe but the meteorites from Mars and Vesta are not. One possible explanation is that Mars and Vesta are smaller and the lower pressure attenuated the potential Fe fractionation during core formation. A second possibility is that the intrinsic oxidation states of the planets are causing the differences. However, another option is that the light elements (e.g. S, C, O, H, Si) in the cores of differentiated bodies control the iron isotope fractionation during differentiation. We have conducted experiments at 1 GPa and 1650-1800°C in a piston cylinder apparatus to address how sulfur, carbon and silicon alloyed with iron affect the iron isotopic fractionation between metallic alloy and silicate melt. We find that sulfur has the greatest effect on the iron isotopic

  2. On Principles of IP Phone Technology and Its Future%IP Phone的技术原理及展望

    Institute of Scientific and Technical Information of China (English)

    张祖良; 杨佩林; 陈刚

    2001-01-01

    This paper introduces principles of IP Phone technology. The basic communication model of IP Phone and the framework of connecting PSTN and Internet are presented. It also describes the hardware and software of an IP Phone gateway as well as protocols involving IP Phone core technology. Finally, it makes an analysis on the prospects.%本文介绍了IP Phone技术的发展及技术原理。IP Phone的基本通信模式,与现存的电话网络及国际互联网的连接框架结构。介绍了IP网关的构成所涉及的软硬件技术以及IP Phone的核心技术及涉及的协议规范。最后对IP Phone技术的发展前景进行了科学的分析。

  3. 基于DDR IP核视频图像缓存的设计与实现%Design and Implement of Video Image Buffer Based on DDR IP Core

    Institute of Scientific and Technical Information of China (English)

    熊璟; 唐广; 唐湘成; 黄自力

    2011-01-01

    Nowadays, memory which have big capability and high-speed in image collecting system is needed. DDR can meet the requirements, so it is the artery of memory at present. In this paper, DDR IP core with 64 bit data width is used, it adopted double data rate of DDR and the high-speed buffer specialty of RAM-2port to achieve data transfer and image buffer on two situations which are based on the FPGA exploit board of Cyclone Ⅲ series of Quartus Ⅱ of Altera company, the design of the system on Signal Tap Ⅱ which is a logic analysis tool is debugged and analyzed.%在现代图像采集显示系统中,常常需要用到大容量、高速度的存储器,DDR为当前存储器应用的主流.采用了64 bit数据位宽的DDR IP核利用DDR的双倍数据传输速度的优点并结合了双口RAM的高速缓存特点,基于Ahera公司的Cyclone Ⅲ系列FPGA开发板在两种平台下实现了数据传输和图像缓存,并使用逻辑分析仪Signal TapⅡ对设计进行调试和分析.

  4. Research on TCP/IP computer network congestion control%对TCP/IP计算机网络拥塞控制的研究

    Institute of Scientific and Technical Information of China (English)

    余学杰

    2014-01-01

    为提升计算机的网络性能,更好地避免拥塞现象的发生,需要对其进行必要的技术控制。鉴于此,对基于TCP/IP协议的网络拥塞控制方法进行分析。在TCP拥塞控制中主要采用TCP Tahoe,TCP Reno,TCP New Reno以及TCP Sack四种方法,其中TCP New Reno对快速恢复算法进行了改进,通过对TCP协议中的Reno进行可视化处理,实行对网络拥塞的有效管理。而IP拥塞控制方法则分为FIFO,FQ和WFQ,RED以及ECN四种类型,通过队列调度管理方式实现了对网络拥塞的有效管理。%To enhance the performance of the computer network and avoid the occurrence of the congestion phenomenon,it is necessary to carry out the effective technical control. In view of this,the network congestion control methods based on TCP/IP protocol are analyzed. Four methods of TCP Tahoe,TCP Reno,TCP New Reno and TCP Sack are used for TCP congestion control;in which fast recovery algorithm was improved by means of TCP New Reno. The visualization processing can be per-formed through the Reno in TCP protocol to implement the effective management of network congestion. The IP congestion con-trol method can be divided into FIFO,FQ/WFQ,RED and ECN to realize the effective management of network congestion by queue scheduling management pattern.

  5. A Novel Framework for IP DiffServ over Optical Burst Switching Networks

    Institute of Scientific and Technical Information of China (English)

    Ke-Ping Long; Yun Li; Rodney S.Tucker; Chong-Gang Wang

    2004-01-01

    This paper presents a novel framework for IP Differentiated Services (DiffServ) over optical burst switching (OBS), namely, DS-OBS. The network architecture, functional model of edge nodes and core nodes, the control packet format, a novel burst assembly scheme at ingress nodes and scheduling algorithm of core nodes are presented. The basic idea is to apply DiffServ capable burst assembly at ingress nodes and perform different per hop behavior (PHB) electronic treatments for control packets of different QoS class services at core nodes. Simulation results show that the proposed schemes can provide the best differentiated service for expedited forwarding (EF), assured forwarding (AF) and best effort (BE) services in terms of end-to-end deay, throughput and IP packet loss probability.

  6. Voice over IP Security

    CERN Document Server

    Keromytis, Angelos D

    2011-01-01

    Voice over IP (VoIP) and Internet Multimedia Subsystem technologies (IMS) are rapidly being adopted by consumers, enterprises, governments and militaries. These technologies offer higher flexibility and more features than traditional telephony (PSTN) infrastructures, as well as the potential for lower cost through equipment consolidation and, for the consumer market, new business models. However, VoIP systems also represent a higher complexity in terms of architecture, protocols and implementation, with a corresponding increase in the potential for misuse. In this book, the authors examine the

  7. IP Routing Protocols

    Science.gov (United States)

    Nolasco Pinto, Armando

    2002-03-01

    Uyless Black is a widely known expert in computer networks and data communications. He is author of more than ten books in the communication technologies field, which puts him in a good position to address this topic. In IP Routing Protocols he starts by providing the background and concepts required for understanding TCP/IP technology. This is done clearly and assumes little prior knowledge of the area. As might be expected, he emphasizes the IP route discovery problem. Later he details several routing protocols.

  8. Voice over IP

    OpenAIRE

    Mantula, Juha

    2006-01-01

    Tämä opinnäytetyö käsittelee Voice over Internet Protocol -tekniikkaa ja sen tuomia mahdollisuuksia yrityselämässä. Teoriaosa käsittelee VoIP:n kannalta tärkeitä pro-tokollia ja standardeja, VoIP:n ominaisuuksia sekä esittelee erilaisia puheohjelmia, jotka käyttävät VoIP-tekniikkaa hyväkseen. Empiirinen osuus tutkii Viestintä Ky Pitkärannan Skype-ohjelman käyttöä. Työn tarkoituksena on selvittää VoIP:n hyviä ja huonoja puolia ja sitä kuinka tek-niikkaa voidaan käyttää hyväksi päivittäisessä ...

  9. Wireless IP Telephony

    CERN Document Server

    Gerami, Mohsen

    2010-01-01

    The convergence of traditional telecommunications and the Internet is creating new network-based service delivery opportunities for telecommunications companies carriers, service providers, and network equipment providers. Voice over Wireless IP is one of the most exciting new developments emerging within the telephony market. It is set to revolutionize the delivery of mobile voice Services and provide exciting new opportunities for operators and service providers alike. This survey discusses principal of Wireless IP Telephony.

  10. Building RNC in All-IP Wireless Networks using Network Processors

    Institute of Scientific and Technical Information of China (English)

    CHENG Sheng; NI Xian-le; ZHU Xin-ning; DING Wei

    2004-01-01

    This paper describes a solution to build network-processor-based Radio Network Controller (RNC) in all-IP wireless networks, it includes the structure of the 3rd Generation (3G) wireless networks and the role of network nodes, such as Base Station (BS), RNC, and Packet-Switched Core Networks (PSCN). The architecture of IXP2800 network processor; the detailed implementation of the solution on IXP2800-based RNC are also covered. This solution can provide scalable IP forward features and it will be widely used in 3G RNCs.

  11. 基于TCP/IP协议的智能家居控制系统设计%Design of intelligent home control system based on TCP/IP protocol

    Institute of Scientific and Technical Information of China (English)

    程文彬; 曾艳

    2014-01-01

    A remote control system of home appliances was designed based on TCP/IP protocol and 433 MHz RF wireless communication technology. With STM32F103VCT6 microcontroller as the core control chip, the DM9000AEP network interface chip (Ethernet controller) is used in the system to realize communication between MCU and Internet servers, and CC1101 chip is used to implement RF wireless communication between MCU and home appliances microcontroller. The home internal network is constructed with 433 MHz wireless communication network and the home external network is established with TCP/IP protocol. The web server can receive multiple users’ requests at the same time and handle communications between the web server and corresponding client-side through network service program. The test for the fan proves that the fan can be controlled by the system remotely.%基于TCP/IP协议和433 MHz射频无线通信技术,设计了一种用户远程家电控制系统。该系统选用STM32F103VCT6单片机作为核心控制芯片,采用DM9000AEP 网络接口芯片(以太网控制器)实现单片机与互联网服务器之间的通信,同时使用CC1101芯片实现单片机与家电微控制器的射频无线通信,并通过433 MHz无线通信网络构建家庭内部网络,运用TCP/IP协议构建家庭外部网络。网络服务器可同时接收多个用户请求,并用网络服务程序处理与对应客户端的通信。通过对风扇进行的测试证明,该方案能够通过互联网远程控制风扇。

  12. OSI and TCP/IP

    Science.gov (United States)

    Randolph, Lynwood P.

    1994-01-01

    The Open Systems Interconnection Transmission Control Protocol/Internet Protocol (OSI TCP/IP) and the Government Open Systems Interconnection Profile (GOSIP) are compared and described in terms of Federal internetworking. The organization and functions of the Federal Internetworking Requirements Panel (FIRP) are discussed and the panel's conclusions and recommendations with respect to the standards and implementation of the National Information Infrastructure (NII) are presented.

  13. Analysis of High Temperature Reactor Control Rod Worth for the Initial and Full Core

    Science.gov (United States)

    Oktajianto, Hammam; Setiawati, Evi; Anam, Khoirul; Sugito, Heri

    2017-01-01

    Control rod is one important component in a nuclear reactor. In nuclear reactor operations the control rod functions to shut down the reactor. This research analyses ten control rods worth of HTR (High Temperature Reactor) at initial and full core. The HTR in this research adopts HTR-10 China and HTR- of pebble bed. Core calculations are performed by using MCNPX code after modelling the entire parts of core in condition of ten control rods fully withdrawn, all control rods in with 20 cm ranges of depth and the use of one control rod. Pebble bed and moderator balls are distributed in the core zone using a Body Centred Cubic (BCC) lattice by ratio of 57:43. The research results are obtained that the use of one control rod will decrease the reactor criticality of 2.04±0.12 %Δk/k at initial core and 1.57±0.10 %Δk/k at full core. The deeper control rods are in, the lesser criticality of reactor is with reactivity of ten control rods of 16.41±0.11 %Δk/k at initial core and 15.43±0.11 %Δk/k at full core. The results show that the use of ten control rods at full core will keep achieving subcritical condition even though the reactivity is smaller than reactivity at initial core.

  14. Design of LFM Pulse Compression Based on FPGA IP Core%线性调频信号基于FPGA IP核的脉冲压缩设计

    Institute of Scientific and Technical Information of China (English)

    张旭; 李巍

    2011-01-01

    A hardware platform based on the field programmable gate array ( FPGA) was designed to implement the digital puLse compression of LFM (Line Frequency Modulation) signal. The design method of pulse compression based on FPGA IP core is proposed in this thesis. The theoretical analysis and MATLAB simulation are performed for pulse compression. With the accomplishment of designs, a comprehensive evaluation test on system software and hardware was conducted, as well as analysis on result of pulse compression based real-time experimental data. The result shows that the system is capable to perform 1 024-points pulse compression. The indexes of the amplitude ratio of main lobe to side lobe and mail lobe width are consistent with the result of theoretical simulation. The design method can conduct parameter setting flexibly, simplify software design and shorten the period of research and development.%为实现线性调频信号的数字脉冲压缩,设计一个FPGA硬件平台,并着重提出一种基于FPGA IP核的脉冲压缩设计方法.针对脉冲压缩进行了理论分析和Matlab仿真,设计完成后对系统软、硬件进行了全面测试,并根据实测数据对脉冲压缩结果进行了分析.结果表明,该系统可实现1 024点的脉冲压缩功能,主副瓣比、主瓣宽度等指标与理论仿真结果一致.该方法的参数设置灵活,可以简化软件设计,缩短研发周期.

  15. Voice over IP in Wireless Heterogeneous Networks

    DEFF Research Database (Denmark)

    Fathi, Hanane; Chakraborty, Shyam; Prasad, Ramjee

    The convergence of different types of traffic has preceded the convergence of systems and services in a wireless heterogeneous network. Voice and data traffic are usually treated separate in both 2G and 2.5G wireless networks. With advances in packet switching technology and especially......IP communications are difficult to achieve in a time-varying environment due to channel errors and traffic congestion and across different systems. The provision of VoIP in wireless heterogeneous networks requires a set of time-efficient control mechanisms to support a VoIP session with acceptable quality...

  16. 75 FR 22816 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel: Revitalizing Core...

    Science.gov (United States)

    2010-04-30

    ... Control Special Emphasis Panel: Revitalizing Core Environmental Health Programs Through the Environmental... initial review, discussion, and evaluation of applications received in response to ``Revitalizing...

  17. 基于Octeon多核网络处理器的IPv6联动IPS研究与设计%Research and Design of Linked IPS Based on Octeon Multi-core Network Processor for IPv6

    Institute of Scientific and Technical Information of China (English)

    杨吉喆; 王玲玲; 陆建德

    2011-01-01

    对基于Octeon多核网络处理器的新一代IPv6高速网络联动入侵防御系统进行研究,设计了新型联动入侵防御原型.系统基于Octeon多核的高速处理,并结合了IPv6网络中入侵的新特点.在基于入侵检测规则库规则匹配技术的基础上,运用新型的协议分析技术和基于流的检测技术,在Octeon多核间分配控制层与数据层的不同执行,采用命名块机制进行多核间通信,通过数据层核向控制层核的反馈,实现了流处理及协议分析模块与控制模块的高速联动.系统实现了Gbps级的高速入侵检测与联动防御处理.%The paper has made research to the Linked Intrusion Prevention System based on Octeon multi-core network processor for new generation high-speed IPv6 network.,and designed a new type of prototype.The system design is based on high-speed processing on Octeon multi-core,and combines new intrusion characteristics occurred in IPv6 network.On the basis of the technique of matching rules in rule library for intrusion detection,and using the new protocol analysis and flow-based detection techniques,the different executions including control plane and data plane are distributed on multiple cores of Octeon.Adopting the mechanism of named blocks to communicate between multiple cores,and by means of the feedbacks from the cores running data plane code to the control plane core,the system has realized the high-speed linking between the flow processing,protocol analysis module and the control module,which is competent for the high-speed intrusion detection and linked prevention at Gbps level.

  18. IP over DWDM

    Science.gov (United States)

    Allen, Mark E.

    2003-04-01

    The industry has been full of many lively debates about exactly how the functions of layer 1 and 2 (physical layer and data-link layer) will be orchestrated to support the growing amount of IP traffic. In effect, this book must simultaneously address layers 1 through 3. Two main strengths of the book are in describing current state-of-the-art research in very-high-speed IP networks and in detailing the standards activities related to net-work management, software, and signaling.

  19. Safeguarding nonhuman primate iPS cells with suicide genes.

    Science.gov (United States)

    Zhong, Bonan; Watts, Korashon L; Gori, Jennifer L; Wohlfahrt, Martin E; Enssle, Joerg; Adair, Jennifer E; Kiem, Hans-Peter

    2011-09-01

    The development of technology to generate induced pluripotent stem (iPS) cells constitutes one of the most exciting scientific breakthroughs because of the enormous potential for regenerative medicine. However, the safety of iPS cell-related products is a major concern for clinical translation. Insertional mutagenesis, possible oncogenic transformation of iPS cells or their derivatives, or the contamination of differentiated iPS cells with undifferentiated cells, resulting in the formation of teratomas, have remained considerable obstacles. Here, we demonstrate the utility of suicide genes to safeguard iPS cells and their derivatives. We found suicide genes can control the cell fate of iPS cells in vitro and in vivo without interfering with their pluripotency and self-renewal capacity. This study will be useful to evaluate the safety of iPS cell technology in a clinically highly relevant, large animal model and further benefit the clinical use of human iPS cells.

  20. Mobile IP and protocol authentication extension

    CERN Document Server

    Nguyen, Phuc V

    2011-01-01

    Mobile IP is an open standard, defined by the Internet Engineering Task Force (IETF) RFC 3220. By using Mobile IP, you can keep the same IP address, stay connected, and maintain ongoing applications while roaming between IP networks. Mobile IP is scalable for the Internet because it is based on IP - any media that can support IP can support Mobile IP.

  1. Digital signage sobre IP

    OpenAIRE

    Casademont Filella, Albert

    2012-01-01

    Projecte que versa sobre el disseny i la implementació d'un sistema de Digital Signage (Cartelleria Digital) sobre IP, creant un gestor que permeti controlar de forma remota tot un conjunt de petits dispositius connectats a pantalles que emeten continguts multimèdia com vídeos, imatges, feeds rss...

  2. Controlling core/shell Au/FePt nanoparticle electrocatalysis via changing the core size and shell thickness.

    Science.gov (United States)

    Sun, Xiaolian; Li, Dongguo; Guo, Shaojun; Zhu, Wenlei; Sun, Shouheng

    2016-02-01

    Using a modified seed-mediated method, we synthesized core/shell Au/FePt nanoparticles (NPs) with Au sizes of 4, 7, and 9 nm and the FePt shell was controlled to have similar FePt compositions and 0.5, 1, and 2 nm thickness. We studied both core and shell effects on electrochemical and electrocatalytic properties of the Au/FePt NPs, and found that the Au core did change the redox chemistry of the FePt shell and promoted its electrochemical oxidation of methanol. The catalytic activity was dependent on the FePt thicknesses, but not much on the Au core sizes, and the 1 nm FePt shell was found to be the optimal thickness for catalyzing methanol oxidation in 0.1 M HClO4 + 0.1 M methanol, offering not only high activity (1.19 mA cm(-2) at 0.5 V vs. Ag/AgCl), but also enhanced stability. Our studies demonstrate a general approach to the design and tuning of shell catalysis in the core/shell structure to achieve optimal catalysis for important electrochemical reactions.

  3. RelationshipbetweentheexpressionofIP-10and IP-10mRNAinperipheralbloodandHBVDNA levelinpatientswithcirrhosis

    Institute of Scientific and Technical Information of China (English)

    Jian Wang; Ping-Ping Wang; Gui-Ju Xiang; Xiao-Bin Hu

    2010-01-01

    BACKGROUND:Post-hepatitic cirrhosis is regarded as common and severe form of liver damage. Interferonγ-inducible protein 10 (IP-10), a member of the non-ELR (glutamic-leucine-arginine) motif CXC chemokine family, has recently been shown to recruit and activate speciifc subsets of leukocytes to sites of inlfammation or an immune response during the development of hepatic cirrhosis. However, the effects of IP-10 and IP-10 mRNA on inlfammatory inifltration at local sites and in the peripheral blood of patients with post-hepatitic cirrhosis as well as their relationship with viral load are still poorly deifned. This study aimed to detect the relationship between the expression of IP-10 in serum, IP-10 mRNA in peripheral blood mononuclear cells (PBMCs), and the levels of HBV DNA in the serum of patients, and to explore their role in the pathogenesis of cirrhosis. METHODS:Typical patients with cirrhosis after HBV infection were selected, and their serum IP-10 concentrations were evaluated with ELISA, the content of IP-10 mRNA in PBMCs was measured by real-time PCR, and the load of HBV DNA in serum and PBMCs was assessed by semi-quantitative analysis of gel imaging. RESULTS:The levels of IP-10 in serum and IP-10 mRNA in PBMCs of patients with cirrhosis were 299.9±77.2 pg/ml and 0.7500±0.1495, respectively. They were higher than those of controls (P CONCLUSIONS:The levels of IP-10 and IP-10 mRNA in the peripheral blood of patients with cirrhosis increase are closely correlated with the load of HBV DNA in serum, and play a key role in the progression of post-hepatitic cirrhosis.

  4. Sub-nanometer dimensions control of core/shell nanoparticles prepared by atomic layer deposition.

    Science.gov (United States)

    Weber, M J; Verheijen, M A; Bol, A A; Kessels, W M M

    2015-03-06

    Bimetallic core/shell nanoparticles (NPs) are the subject of intense research due to their unique electronic, optical and catalytic properties. Accurate and independent control over the dimensions of both core and shell would allow for unprecedented catalytic performance. Here, we demonstrate that both core and shell dimensions of Pd/Pt core/shell nanoparticles (NPs) supported on Al2O3 substrates can be controlled at the sub-nanometer level by using a novel strategy based on atomic layer deposition (ALD). From the results it is derived that the main conditions for accurate dimension control of these core/shell NPs are: (i) a difference in surface energy between the deposited core metal and the substrate to obtain island growth; (ii) a process yielding linear growth of the NP cores with ALD cycles to obtain monodispersed NPs with a narrow size distribution; (iii) a selective ALD process for the shell metal yielding a linearly increasing thickness to obtain controllable shell growth exclusively on the cores. For Pd/Pt core/shell NPs it is found that a minimum core diameter of 1 nm exists above which the NP cores are able to catalytically dissociate the precursor molecules for shell growth. In addition, initial studies on the stability of these core/shell NPs have been carried out, and it has been demonstrated that core/shell NPs can be deposited by ALD on high aspect ratio substrates such as nanowire arrays. These achievements show therefore that ALD has significant potential for the preparation of tuneable heterogeneous catalyst systems.

  5. IP and ATM Integration

    OpenAIRE

    Mannie, E.; Corridoni, J.; Cremonese, P.; Giordano, Silvia

    1999-01-01

    The performance limits of the current Internet make the integration of IP with ATM a hotly debated issue in the networking arena, leading to various competing approaches and products. Legitimate technical and market issues are, however, often intertwined with biased views and hype, with vendors competing in the standards arena as well as on the markets. Together with the speed of technical evolution, this causes confusion for purchasers of networking equipment who, usually preferring a single...

  6. Control Yourself, or at Least Your Core Self

    Science.gov (United States)

    Austin, Lisa M.

    2010-01-01

    Contemporary privacy debates regarding new technologies often define privacy in terms of control over personal information such that the privacy "problem" is a lack of control and the privacy "solution" is increased control. This article questions the control-paradigm by pointing to its parallels with earlier debates in the…

  7. The effect of zirconia on flexural strength of IPS Empress 2 ceramic

    Directory of Open Access Journals (Sweden)

    Kermanshah H

    2007-06-01

    Full Text Available Background and Aim: All ceramic, inlay-retained resin bonded fixed partial denture is a conservative method for replacement of missing teeth, because of minimal tooth reduction. The connector between the retainer and the pontic is the weak point of these bridges. Reinforcement of ceramic core will increase the clinical longevity. The aim of this study was to determine the effect of zirconia on flexural strength of IPS Empress 2 core ceramic.Materials and Methods: In this experimental in vitro study, twenty eight bar shape specimens (17´3.1´3.1 mm were made of four different materials: (1 Slip casting in-ceram alumina core (control group (2 Hot-pressed lithium disilicate core ceramic (IPS Empress 2 (3 IPS Empress 2 with cosmopost (zirconia post inserted longitudinally in the center of the bar (4 IPS Empress 2 with cosmopost (zirconia post inserted longitudinally in bottom of the bar. Specimens were subjected to three-point flexure loading with the span of 15mm, at a cross-head speed of 0.5 mm/min. Failure loads were recorded and analyzed using one-way ANOVA and Tomhane Post-hoc tests and p<0.05 was set as the level of significance. Fractured surfaces were then observed by scanning electron microscope (SEM. Four additional samples were made as the third group, and zirconia-IPS interface was observed by SEM before fracture.Results: Mean values and standard deviations of three point flexural strengths of groups 1 to 4, were: 378.4±44.6, 258.6±27.5, 144.3±51.7, 230±22.3 MPa respectively. All the groups were statistically different from each other (P<0.05, except groups 2 and 4. The flexural strengths of groups 2, 3, 4 were significantly lower than group 1. Group 3 had the lowest flexural strength. SEM analysis showed that the initiated cracks propagated in the interface of zirconia post and IPS Empress 2 ceramic.Conclusion: Based on the results of this study, inserting zirconia post (cosmopost in IPS Empress 2 ceramic does not reinforce all

  8. The IDvIP Trial: A two-centre randomised double-blind controlled trial comparing intramuscular diamorphine and intramuscular pethidine for labour analgesia

    Directory of Open Access Journals (Sweden)

    Thomas Peter

    2011-07-01

    Full Text Available Abstract Background Intramuscular pethidine is routinely used throughout the UK for labour analgesia. Studies have suggested that pethidine provides little pain relief in labour and has a number of side effects affecting mother and neonate. It can cause nausea, vomiting and dysphoria in mothers and can cause reduced fetal heart rate variability and accelerations. Neonatal effects include respiratory depression and impaired feeding. There are few large studies comparing the relative side effects and efficacy of different opioids in labour. A small trial comparing intramuscular pethidine with diamorphine, showed diamorphine to have some benefits over pethidine when used for labour analgesia but the study did not investigate the adverse effects of either opioid. Methods The Intramuscular Diamorphine versus Intramuscular Pethidine (IDvIP trial is a randomised double-blind two centre controlled trial comparing intramuscular diamorphine and pethidine regarding their analgesic efficacy in labour and their side effects in mother, fetus and neonate. Information about the trial will be provided to women in the antenatal period or in early labour. Consent and recruitment to the trial will be obtained when the mother requests opioid analgesia. The sample size requirement is 406 women with data on primary outcomes. The maternal primary outcomes are pain relief during the first 3 hours after trial analgesia and specifically pain relief after 60 minutes. The neonatal primary outcomes are need for resuscitation and Apgar Score Discussion If the trial demonstrates that diamorphine provides better analgesia with fewer side effects in mother and neonate this could lead to a change in national practice and result in diamorphine becoming the preferred intramuscular opioid for analgesia in labour. Trial Registration ISRCTN14898678 Eudra No: 2006-003250-18, REC Reference No: 06/Q1702/95, MHRA Authorisation No: 1443/0001/001-0001, NIHR UKCRN reference 6895, RfPB grant

  9. The efficacy of a supervised and a home-based core strengthening programme in adults with poor core stability: a three-arm randomised controlled trial.

    Science.gov (United States)

    Chuter, V H; de Jonge, X A K Janse; Thompson, B M; Callister, R

    2015-03-01

    Poor core stability is linked to a range of musculoskeletal pathologies and core-strengthening programmes are widely used as treatment. Treatment outcomes, however, are highly variable, which may be related to the method of delivery of core strengthening programmes. We investigated the effect of identical 8 week core strengthening programmes delivered as either supervised or home-based on measures of core stability. Participants with poor core stability were randomised into three groups: supervised (n=26), home-based (n=26) or control (n=26). Primary outcomes were the Sahrmann test and the Star Excursion Balance Test (SEBT) for dynamic core stability and three endurance tests (side-bridge, flexor and Sorensen) for static core stability. The exercise programme was devised and supervised by an exercise physiologist. Analysis of covariance on the change from baseline over the 8 weeks showed that the supervised group performed significantly better on all core stability measures than both the home-based and control group. The home-based group produced significant improvements compared to the control group in all static core stability tests, but not in most of the dynamic core stability tests (Sahrmann test and two out of three directions of the SEBT). Our results support the use of a supervised core-strengthening programme over a home-based programme to maximise improvements in core stability, especially in its dynamic aspects. Based on our findings in healthy individuals with low core stability, further research is recommended on potential therapeutic benefits of supervised core-strengthening programmes for pathologies associated with low core stability. ACTRN12613000233729. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  10. An Infrastructural IP for Interactive MPEG-4 SoC Functional Verification

    Directory of Open Access Journals (Sweden)

    Trio Adiono

    2013-09-01

    Full Text Available This paper introduces a specific architecture including an infrastructural IP for functional verification and diagnostics, which is suitable for functional core-based testing of an MPEG4 SoC. Our advanced MPEG4 SoC results in a high complexity SoC with limited physical access to many different functional cores. The proposed test method provides direct monitoring and control for each core, which enables core verification at actual speed. It significantly decreases the verification time due to the large number of required test vectors in typical MPEG4 verification. Furthermore, it also makes the system scalable for functional core expansion due to upgrading of standards. The proposed infrastructural IP is also linked to PC-based interactive tools to simplify the verification of individual and integrated cores. It also provides detailed diagnostic data that enables simple system debugging. The debugging tools also feature test-pattern generation and simulation of expected values. Actual system implementation has shown full functionality of our proposed method.

  11. An Infrastructural IP for Interactive MPEG-4 SoC Functional Verification

    Directory of Open Access Journals (Sweden)

    Trio Adiono

    2009-05-01

    Full Text Available This paper introduces a specific architecture including an infrastructural IP for functional verification and diagnostics, which is suitable for functional core-based testing of an MPEG4 SoC. Our advanced MPEG4 SoC results in a high complexity SoC with limited physical access to many different functional cores. The proposed test method provides direct monitoring and control for each core, which enables core verification at actual speed. It significantly decreases the verification time due to the large number of required test vectors in typical MPEG4 verification. Furthermore, it also makes the system scalable for functional core expansion due to upgrading of standards. The proposed infrastructural IP is also linked to PC-based interactive tools to simplify the verification of individual and integrated cores. It also provides detailed diagnostic data that enables simple system debugging. The debugging tools also feature test-pattern generation and simulation of expected values. Actual system implementation has shown full functionality of our proposed method.

  12. IP Phone 综述

    Institute of Scientific and Technical Information of China (English)

    夏华; 陈常嘉

    2000-01-01

    IP Phone代表下一代电话技术,是目前的热点,它通过分组交换网络来传输话音,是开放式分组业务的一种。本文从IP Phone的出现谈起,简要介绍了IP Phone的优势,工作原理和相关标准,着重分析了IP Phone面临的挑战与机遇,并展望了IP Phone的发展前景。

  13. Presence in the IP Multimedia Subsystem

    Directory of Open Access Journals (Sweden)

    Ling Lin

    2007-01-01

    Full Text Available With an ever increasing penetration of Internet Protocol (IP technologies, the wireless industry is evolving the mobile core network towards all-IP network. The IP Multimedia Subsystem (IMS is a standardised Next Generation Network (NGN architectural framework defined by the 3rd Generation Partnership Project (3GPP to bridge the gap between circuit-switched and packet-switched networks and consolidate both sides into on single all-IP network for all services. In this paper, we provide an insight into the limitation of the presence service, one of the fundamental building blocks of the IMS. Our prototype-based study is unique of its kind and helps identifying the factors which limit the scalability of the current version of the presence service (3GPP TS 23.141 version 7.2.0 Release 7 [1], which will in turn dramatically limit the performance of advanced IMS services. We argue that the client-server paradigm behind the current IMS architecture does not suite the requirements of the IMS system, which defies the very purpose of its introduction. We finally elaborate on possible avenues for addressing this problem.

  14. The design of reload cores using optimal control theory

    Energy Technology Data Exchange (ETDEWEB)

    Terney, W.B.; Williamson, E.A.

    1982-11-01

    A formal approach for the optimization of the final design of reload cores has been devised and verified. The method is based on applying the calculus of variations (Pontryagin's principle) to the normal flux and depletion system equations. The resulting set of coupled system, Euler-Lagrange (E-L), and optimality equations are solved iteratively. This is done by assuming a loading pattern for the old fuel, first solving the system equations, and then the E-L equations. The pattern is then modified by using the optimality (or Pontryagin) condition, and the process is repeated until no further improvements can be made. A computer program, OPMUV, implementing these procedures has been written and verified. The code can handle two-dimensional, quarter-core symmetric configurations with up to 241 assemblies and 4 nodes per assembly with modified one-group theory. It also has the capability of optimizing over the entire depletion cycle as well as just at the beginning of cycle (BOC). The results show that the procedure does work. In all cases tried, the method led to a reduction in nodal peaks of 1 to 3% over the final designer-obtained loading pattern within a couple of iterations. These savings carry over to comparable reductions in pin peaks when the optimized patterns are used in four-group, fine-mesh calculations. Since the changes on each iteration are limited to ensure convergence, the method is thus well suited for the final fine tuning of the normally obtained patterns to gain an extra few percent in power flattening.

  15. Impact of artefact removal on ChIP quality metrics in ChIP-seq and ChIP-exo data.

    Directory of Open Access Journals (Sweden)

    Thomas Samuel Carroll

    2014-04-01

    Full Text Available With the advent of ChIP-seq multiplexing technologies and the subsequent increase in ChIP-seq throughput, the development of working standards for the quality assessment of ChIP-seq studies has received significant attention. The ENCODE consortium’s large scale analysis of transcription factor binding and epigenetic marks as well as concordant work on ChIP-seq by other laboratories has established a new generation of ChIP-seq quality control measures. The use of these metrics alongside common processing steps has however not been evaluated. In this study, we investigate the effects of blacklisting and removal of duplicated reads on established metrics of ChIP-seq quality and show that the interpretation of these metrics is highly dependent on the ChIP-seq preprocessing steps applied. Further to this we perform the first investigation of the use of these metrics for ChIP-exo data and make recommendations for the adaptation of the NSC statistic to allow for the assessment of ChIP-exo efficiency.

  16. Impact of artifact removal on ChIP quality metrics in ChIP-seq and ChIP-exo data.

    Science.gov (United States)

    Carroll, Thomas S; Liang, Ziwei; Salama, Rafik; Stark, Rory; de Santiago, Ines

    2014-01-01

    With the advent of ChIP-seq multiplexing technologies and the subsequent increase in ChIP-seq throughput, the development of working standards for the quality assessment of ChIP-seq studies has received significant attention. The ENCODE consortium's large scale analysis of transcription factor binding and epigenetic marks as well as concordant work on ChIP-seq by other laboratories has established a new generation of ChIP-seq quality control measures. The use of these metrics alongside common processing steps has however not been evaluated. In this study, we investigate the effects of blacklisting and removal of duplicated reads on established metrics of ChIP-seq quality and show that the interpretation of these metrics is highly dependent on the ChIP-seq preprocessing steps applied. Further to this we perform the first investigation of the use of these metrics for ChIP-exo data and make recommendations for the adaptation of the NSC statistic to allow for the assessment of ChIP-exo efficiency.

  17. Monitoring of resistivity and IP: The Syscal Monitoring Unit (SMU), a new system dedicated for remote control of the Syscal Pro resistivimeter

    Science.gov (United States)

    Gance, Julien; Leite, Orlando; Texier, Benoît; Bernard, Jean; Truffert, Catherine

    2017-04-01

    All matter, gas, fluids and energy transfer at soil/atmosphere interface govern soil, rock and life evolution in the critical zone. Near surface electrical resistivity and chargeability modifications with time are distinguishable and process related enough for bringing to geoscientist relevant clue within this highly studied zone. Such non-invasive measurements are directly sensitive to a wide range of remarkable parameters (soil water content, temperature, soil water conductivity, clay content, etc.). In order to increase physical, chemical and biological processes understanding, resistivity and IP monitoring remain the less costly and the more powerful method among others. Indeed, these methods are the most suitable to image 2D/3D and 4D processes in an automated way. Whether such geophysical survey are for academic knowledge, waste landfill leakage or landslide monitoring purpose, it has to be done during medium to long period of time (from days to years). Nevertheless, operators don't need to be on site all the survey long. So, equipment manufacturers had to propose them suitable solutions for their needs. Syscal Pro resistivimeter is well adapted to observe the critical zone down to 100 m depth with its 10 channels and 250 watts. Its high speed recording (up to 1000 records/min) ability is also suited to apprehend expected kinetics of studied phenomena. In this context, IRIS Instruments developed a dedicated remote unit able to remote control Syscal Pro resistivimeter. It allows to change acquisition parameters (sequences), to check the main constant (battery levels, internal temperature) and to alert in case of any recording troubles. Data can be sent directly to FTP or SSH server or by mail for an easy and constant access to the data. Alert functionalities sent by mail in case of low battery or too many outliers present in the data are welcome to check the dimensioning of the energy source and for easily maintaining the long-term acquisition necessary for

  18. Voice over IP in Wireless Heterogeneous Networks

    DEFF Research Database (Denmark)

    Fathi, Hanane; Chakraborty, Shyam; Prasad, Ramjee

    The convergence of different types of traffic has preceded the convergence of systems and services in a wireless heterogeneous network. Voice and data traffic are usually treated separate in both 2G and 2.5G wireless networks. With advances in packet switching technology and especially with the d...... and to the discruption caused by the user mobility during the session. Voice over IP in Wireless Hetetrogeneous Networks thus investigates and proposes cross-layer techniques for realizing time-efficient control mechanisms for VoIP: signaling, mobility and security.......The convergence of different types of traffic has preceded the convergence of systems and services in a wireless heterogeneous network. Voice and data traffic are usually treated separate in both 2G and 2.5G wireless networks. With advances in packet switching technology and especially....... The focus of Voice over IP in Wierless Heterogeneous Networks is on mechanisms that affect the VoIP user satisfaction  while not explicitly involved in the media session. This relates to the extra delays introduced by the security and the signaling protocols used to set up an authorized VoIP session...

  19. Foundations of hardware IP protection

    CERN Document Server

    Torres, Lionel

    2017-01-01

    This book provides a comprehensive and up-to-date guide to the design of security-hardened, hardware intellectual property (IP). Readers will learn how IP can be threatened, as well as protected, by using means such as hardware obfuscation/camouflaging, watermarking, fingerprinting (PUF), functional locking, remote activation, hidden transmission of data, hardware Trojan detection, protection against hardware Trojan, use of secure element, ultra-lightweight cryptography, and digital rights management. This book serves as a single-source reference to design space exploration of hardware security and IP protection. · Provides readers with a comprehensive overview of hardware intellectual property (IP) security, describing threat models and presenting means of protection, from integrated circuit layout to digital rights management of IP; · Enables readers to transpose techniques fundamental to digital rights management (DRM) to the realm of hardware IP security; · Introduce designers to the concept of salutar...

  20. Controlling the Exchange Bias Field in Co core/CoO Shell Nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Feygenson, M.; Yiu, Y.; Kou, A.; Kim, K.-S.; Aronson, M.C.

    2010-05-28

    We have determined how the anomalous exchange bias effect in Co/CoO nanoparticles of 11 nm in diameter depends on the Co core and CoO shell dimensions. The oxidation of the Co nanoparticles used in this study is carefully controlled, yielding highly crystalline and oriented interfaces. The dimensions of the core and shell are determined from magnetization and small angle x-ray scattering measurements. The exchange bias field in Co/CoO core-shell nanoparticles depends nonmonotonically on the CoO shell thickness, reaching a maximum value of {approx}7 kOe at 30 K when the core and shell dimensions are similar. We propose that lattice strain induces a net moment at the core-shell interface, and it is the variation of this moment with strain, which is responsible for the vanishing of H{sub EB} at both large and small Co shell thicknesses.

  1. Controlling the exchange bias field in Co core/CoO shell nanoparticles

    Science.gov (United States)

    Feygenson, Mikhail; Yiu, Yuen; Kou, Angela; Kim, Ki-Sub; Aronson, Meigan C.

    2010-05-01

    We have determined how the anomalous exchange bias effect in Co/CoO nanoparticles of 11 nm in diameter depends on the Co core and CoO shell dimensions. The oxidation of the Co nanoparticles used in this study is carefully controlled, yielding highly crystalline and oriented interfaces. The dimensions of the core and shell are determined from magnetization and small angle x-ray scattering measurements. The exchange bias field in Co/CoO core-shell nanoparticles depends nonmonotonically on the CoO shell thickness, reaching a maximum value of ≈7kOe at 30 K when the core and shell dimensions are similar. We propose that lattice strain induces a net moment at the core-shell interface, and it is the variation of this moment with strain, which is responsible for the vanishing of HEB at both large and small Co shell thicknesses.

  2. Introduction à TCP/IP

    OpenAIRE

    Archimbaud, Jean-Luc

    1993-01-01

    • Ce qu'il faut savoir sur les réseaux • Ce qu'il faut savoir sur Ethernet • Généralités sur TCP/IPIP et consort • TCP et consort • Le routage • Interconnexion de réseaux Ethernet et IP • Nommage • Exemples d'applications • Enchaînement des opérations • Daemons et commandes Unix • Glossaire; Engineering school; Cours d'introduction à TCP/IP

  3. Optimization of OSPF Routing in IP Networks

    Science.gov (United States)

    Bley, Andreas; Fortz, Bernard; Gourdin, Eric; Holmberg, Kaj; Klopfenstein, Olivier; Pióro, Michał; Tomaszewski, Artur; Ümit, Hakan

    The Internet is a huge world-wide packet switching network comprised of more than 13,000 distinct subnetworks, referred to as Autonomous Systems (ASs) autonomous system AS . They all rely on the Internet Protocol (IP) internet protocol IP for transport of packets across the network. And most of them use shortest path routing protocols shortest path routing!protocols , such as OSPF or IS-IS, to control the routing of IP packets routing!of IP packets within an AS. The idea of the routing is extremely simple — every packet is forwarded on IP links along the shortest route between its source and destination nodes of the AS. The AS network administrator can manage the routing of packets in the AS by supplying the so-called administrative weights of IP links, which specify the link lengths that are used by the routing protocols for their shortest path computations. The main advantage of the shortest path routing policy is its simplicity, allowing for little administrative overhead. From the network engineering perspective, however, shortest path routing can pose problems in achieving satisfactory traffic handling efficiency. As all routing paths depend on the same routing metric routing!metric , it is not possible to configure the routing paths for the communication demands between different pairs of nodes explicitly or individually; the routing can be controlled only indirectly and only as a whole by modifying the routing metric. Thus, one of the main tasks when planning such networks is to find administrative link weights that induce a globally efficient traffic routing traffic!routing configuration of an AS. It turns out that this task leads to very difficult mathematical optimization problems. In this chapter, we discuss and describe exact integer programming models and solution approaches as well as practically efficient smart heuristics for such shortest path routing problems shortest path routing!problems .

  4. Multi-core System Architecture for Safety-critical Control Applications

    DEFF Research Database (Denmark)

    Li, Gang

    certification cost. Meanwhile, hardware platforms with improved processing power are required to execute the applications of larger size. To tackle the two issues mentioned above, the state of the art approaches are using more Electronic Control Units (ECU) in a federated architecture or increasing...... cores, low power consumption, on-chip interconnection and natural support to on-chip hardware diversity and redundancy at the inter-core level. The objective of this dissertation is to propose a multi-core system architecture for safety-critical control applications with reduced certification cost...... on partitioning design of both multi-core hardware and software architectures, in order to minimize efforts and cost of system certification at the integration time. Hardware architecture design concentrates on a firmware architecture on SoC platforms, providing separated hardware execution environments...

  5. Beyond iPS!

    Directory of Open Access Journals (Sweden)

    Editorial

    2012-01-01

    Full Text Available It’s undoubtedly a jubilant moment for scientists and clinicians working in the stem cell arena as Prof. Gurdon and Prof. Shinya Yamanaka have been chosen for the Nobel Prize in Physiology & Medicine this year. The mystery of cell biology is something unfathomable and probably the work of this duo as well as the other scientists, who have put their hands on in- vitro de-differentiation have opened our eyes to a new window or a new paradigm in cell biology. The iPS invention has brought a lot of hope in terms of potential direct benefits to treat several diseases, which have no definite options at the moment. But, we envisage that several spin-offs could come out of this invention and one very significant spin-off finding recently witnessed is the finding by Prof. Masaharu Seno and his team of researchers at the Okayama University, Japan (Chen L, et al. 2012, PLoS ONE 7(4:e33544.doi:10.1371/journal.pone.0033544. According to Prof. Seno, mouse iPS cells (miPS when cultured in the conditioned medium derived from cancer cell lines, differentiate into cancer stem cells (CSCs. While differentiating into CSCs, they do retain the potential to develop endothelial progenitor cells. Several questions arise here: 1.Are these miPS derived CSCs really pluripotent, even if the terminal differentiation destined to specific phenotypes? 2.Shouldn’t the Cancer Stem Cells be termed as cancer progenitor cells, as till date they are considered to be producing only cancer cells but not pluripotent to yield other types of normal tissues? The spin-offs could be infinite as the process of differentiation and de-differentiation happening due to trillions of signals and pathways, most still remaining not-so-well understood. A special mention should be made to Prof. Shinya Yamanaka as he has several sterling qualities to be a role-model for budding scientists. Apart from his passion for science, which made him shift his career from orthopedics to a cell biologist, his

  6. Control of skin blood flow, sweating, and heart rate - Role of skin vs. core temperature

    Science.gov (United States)

    Wyss, C. R.; Brengelmann, G. L.; Johnson, J. M.; Rowell, L. B.; Niederberger, M.

    1974-01-01

    A study was conducted to generate quantitative expressions for the influence of core temperature, skin temperature, and the rate of change of skin temperature on sweat rate, skin blood flow, and heart rate. A second goal of the study was to determine whether the use of esophageal temperature rather than the right atrial temperature as a measure of core temperature would lead to different conclusions about the control of measured effector variables.

  7. Motor Learning and Control Foundations of Kinesiology: Defining the Academic Core

    Science.gov (United States)

    Fischman, Mark G.

    2007-01-01

    This paper outlines the kinesiological foundations of the motor behavior subdisciplines of motor learning and motor control. After defining the components of motor behavior, the paper addresses the undergraduate major and core knowledge by examining several classic textbooks in motor learning and control, as well as a number of contemporary…

  8. Motor Learning and Control Foundations of Kinesiology: Defining the Academic Core

    Science.gov (United States)

    Fischman, Mark G.

    2007-01-01

    This paper outlines the kinesiological foundations of the motor behavior subdisciplines of motor learning and motor control. After defining the components of motor behavior, the paper addresses the undergraduate major and core knowledge by examining several classic textbooks in motor learning and control, as well as a number of contemporary…

  9. Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.

    Science.gov (United States)

    Li, Cecilia; Lev, Sophie; Saiardi, Adolfo; Desmarini, Desmarini; Sorrell, Tania C; Djordjevic, Julianne T

    2016-04-01

    Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans. Cryptococcal Kcs1 converts IP6 to PP-IP5/IP7, but the kinase converting IP5 to IP6 is unknown. Deletion of a putative IP5 kinase-encoding gene (IPK1) alone (ipk1Δ), and in combination with KCS1 (ipk1Δkcs1Δ), profoundly reduced virulence in mice. However, deletion of KCS1 and IPK1 had a greater impact on virulence attenuation than that of IPK1 alone. ipk1Δkcs1Δ and kcs1Δ lung burdens were also lower than those of ipk1Δ. Unlike ipk1Δ, ipk1Δkcs1Δ and kcs1Δ failed to disseminate to the brain. IP profiling confirmed Ipk1 as the major IP5 kinase in C. neoformans: ipk1Δ produced no IP6 or PP-IP5/IP7 and, in contrast to ipk1Δkcs1Δ, accumulated IP5 and its pyrophosphorylated PP-IP4 derivative. Kcs1 is therefore a dual specificity (IP5 and IP6) kinase producing PP-IP4 and PP-IP5/IP7. All mutants were similarly attenuated in virulence phenotypes including laccase, urease and growth under oxidative/nitrosative stress. Alternative carbon source utilisation was also reduced significantly in all mutants except ipk1Δ, suggesting that PP-IP4 partially compensates for absent PP-IP5/IP7 in ipk1Δ grown under this condition. In conclusion, PP-IP5/IP7, not IP6, is essential for fungal virulence.

  10. Implementation of direct routing mobile IP for solving triangular routing

    Science.gov (United States)

    Jang, Jongwook; Jang, SeongHo; Park, Miri; Lee, Dae-bong

    2001-10-01

    Mobility support on the network layer is of special importance, as the network layer holds together the huge Internet with common protocol IP. Although based on possibility different wireless or wired technologies, all nodes of the network should be able to communicate. Therefore, mobile IP(an extension of the classical IP) has been designed which enablemobility in the Internet without changing existing wired systems. However, mobile IP leaves some points unsolved. Especially, if it comes to security, efficiency of the packet flow that is called triangular routing. Especially triangular routing can cause unnecessary overhead for the network. Furthermore latency can increase dramatically. This is particularly unfortunate if two communicating hosts are separated by transatlantic links. In order to this problem, many methods like IPv6 and ROMIP are proposed. But these methods have limitation. In other words, they have not compatibility because of needing modification of original IP scheme. Especially ROMIP is very complex and the overhead of control message and processing are serious. The problem of inconsistency of Binding caches may occur too. We therefore propose and analyze the performance of the DRMIP (Direct Routing Mobile IP) which do not modify IP source needed in the sender, is compatible with IP and Mobile IP.

  11. Design and performance evaluation of direct routing mobile IP

    Science.gov (United States)

    Jang, Jongwook; Jang, SeongHo; Kim, Kilyeun; Lee, Jung-Tae

    2001-07-01

    Mobility support on the network layer is of special importance, as the network layer holds together the huge Internet with common protocol IP. Although based on possibility different wireless or wired technologies, all nodes of the network should be able to communicate. Therefore, mobile IP (an extension of the classical IP) has been designed which enables mobility in the Internet without changing existing wired systems. However, mobile IP leaves some points unsolved. Especially, if it comes to security, efficient of the packet flow that is called triangular routing. Especially triangular routing can cause unnecessary overhead for the network. Furthermore latency can increase dramatically. This is particularly unfortunate if two communicating hosts are separated by transatlantic links. In order to this problem, many methods like IPv6 and ROMIP are proposed. But these methods have limitation. In other words, they have not compatibility because of needing modification or original IP scheme. Especially ROMIP is very complex and the overhead of control message and processing are serious. The problem of inconsistency of Binding caches may occur tool. We therefore propose and analyze the DRMIP (Direct Routing Mobile IP) which do not modify IP source needed in the sender, is compatible with IP and Mobile IP.

  12. Inositol hexaphosphate (IP6) inhibits cellular proliferation in melanoma.

    Science.gov (United States)

    Rizvi, Irfan; Riggs, Dale R; Jackson, Barbara J; Ng, Alex; Cunningham, Cynthia; McFadden, David W

    2006-06-01

    Inositol Hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate found in food sources high in fiber content. We have previously reported IP6 to have significant inhibitory effects against pancreatic cancer in vitro. We hypothesized that the IP6 would significantly inhibit cell growth of cutaneous melanoma in vitro. The melanoma line HTB68 was cultured using standard techniques and treated with IP6 at doses ranging from 0.2 to 1.0 mM/well. Cell viability was measured by MTT at 72 h. VEGF production was measured in the cell supernatants by ELISA. Apoptosis was evaluated by Annexin V-FITC and results calculated using FACS analysis. Statistical analysis was performed by ANOVA. Significant reductions (P IP6. Overall, IP6 exhibited a mean inhibition of cell growth of 52.1 +/- 11.5% (range, 1.6-83.0%) at 72 h of incubation. VEGF production was significantly reduced (P IP6 (7.5 pg/ml) compared to control (40.9 pg/ml). IP6 significantly increased (P = 0.029) late apoptosis from 5.3 to 7.0% gated events. No changes in necrosis or early apoptosis were observed. Adjuvant treatment of melanoma continues to challenge clinicians and patients. Our findings that IP6 significantly decreased cellular growth, VEGF production and increased late apoptosis in melanoma suggest its potential therapeutic value. Further in vivo studies are planned to evaluate safety and clinical utility of this agent.

  13. Controlled assembly and plasmonic properties of asymmetric core-satellite nanoassemblies.

    Science.gov (United States)

    Yoon, Jun Hee; Lim, Jonghui; Yoon, Sangwoon

    2012-08-28

    The assembly of noble metal nanoparticles offers an appealing means to control and enhance the plasmonic properties of nanostructures. However, making nanoassemblies with easily modifiable gap distances with high efficiency has been challenging. Here, we report a novel strategy to assemble gold nanoparticles (AuNPs) into Janus-type asymmetric core-satellite nanostructures. Markedly different desorption efficiency between large and small AuNPs in ethanol allows us to prepare the asymmetric core-satellite nanoassemblies in a dispersed colloidal state with near 100% purity. The resulting nanoassemblies have well-defined structures in which a core AuNP (51 nm) is covered by an average of 13 ± 3 satellite AuNPs (13 nm) with part of the core surfaces left unoccupied. Strong surface plasmon coupling is observed from these nanoassemblies as a result of the close proximity between the core and the satellites, which appears significantly red-shifted from the surface plasmon resonance frequencies of the constituting nanoparticles. The dependence of the surface plasmon coupling on a gap distance of less than 3 nm is systematically investigated by varying the length of the alkanedithiol linkers. The asymmetric core-satellite nanoassemblies also serve as an excellent surface-enhanced Raman scattering substrate with an enhancement factor of ~10(6). Finally, we demonstrate that the presented assembly method is extendible to the preparation of compositionally heterogeneous core-satellite nanoassemblies.

  14. A Heterogeneous Multi-core Architecture with a Hardware Kernel for Control Systems

    DEFF Research Database (Denmark)

    Li, Gang; Guan, Wei; Sierszecki, Krzysztof

    2012-01-01

    . This paper presents a multi-core architecture incorporating a hardware kernel on FPGAs, intended for high performance applications in control engineering domain. First, the hardware kernel is investigated on the basis of a component-based real-time kernel HARTEX (Hard Real-Time Executive for Control Systems......). Second, a heterogeneous multi-core architecture is investigated, focusing on its performance in relation to hard real-time constraints and predictable behavior. Third, the hardware implementation of HARTEX is designated to support the heterogeneous multi-core architecture. This hardware kernel has......Rapid industrialisation has resulted in a demand for improved embedded control systems with features such as predictability, high processing performance and low power consumption. Software kernel implementation on a single processor is becoming more difficult to satisfy those constraints...

  15. Identifying Core Competencies of Infection Control Nurse Specialists in Hong Kong.

    Science.gov (United States)

    Chan, Wai Fong; Bond, Trevor G; Adamson, Bob; Chow, Meyrick

    2016-01-01

    To confirm a core competency scale for Hong Kong infection control nurses at the advanced nursing practice level from the core competency items proposed in a previous phase of this study. This would serve as the foundation of competency assurance in Hong Kong hospitals. A cross-sectional survey design was used. All public and private hospitals in Hong Kong. All infection control nurses in hospitals of Hong Kong. The 83-item proposed core competency list established in an earlier study was transformed into a questionnaire and sent to 112 infection control nurses in 48 hospitals in Hong Kong. They were asked to rate the importance of each infection prevention and control item using Likert-style response categories. Data were analyzed using the Rasch model. The response rate of 81.25% was achieved. Seven items were removed from the proposed core competency list, leaving a scale of 76 items that fit the measurement requirements of the unidimensional Rasch model. Essential core competency items of advanced practice for infection control nurses in Hong Kong were identified based on the measurement criteria of the Rasch model. Several items of the scale that reflect local Hong Kong contextual characteristics are distinguished from the overseas standards. This local-specific competency list could serve as the foundation for education and for certification of infection control nurse specialists in Hong Kong. Rasch measurement is an appropriate analytical tool for identifying core competencies of advanced practice nurses in other specialties and in other locations in a manner that incorporates practitioner judgment and expertise.

  16. Protection against cancer by dietary IP6 and inositol.

    Science.gov (United States)

    Vucenik, Ivana; Shamsuddin, AbulKalam M

    2006-01-01

    Inositol hexaphosphate (IP(6)) is a naturally occurring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain high-fiber diets, such as cereals and legumes. In addition to being found in plants, IP(6) is contained in almost all mammalian cells, although in much smaller amounts, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. For a long time IP(6) has been recognized as a natural antioxidant. Recently IP(6) has received much attention for its role in cancer prevention and control of experimental tumor growth, progression, and metastasis. In addition, IP(6) possesses other significant benefits for human health, such as the ability to enhance immune system, prevent pathological calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity. In this review we show the efficacy and discuss some of the molecular mechanisms that govern the action of this dietary agent. Exogenously administered IP(6) is rapidly taken up into cells and dephosphorylated to lower inositol phosphates, which further affect signal transduction pathways resulting in cell cycle arrest. A striking anticancer action of IP(6) was demonstrated in different experimental models. In addition to reducing cell proliferation, IP(6) also induces differentiation of malignant cells. Enhanced immunity and antioxidant properties also contribute to tumor cell destruction. Preliminary studies in humans show that IP(6) and inositol, the precursor molecule of IP(6), appear to enhance the anticancer effect of conventional chemotherapy, control cancer metastases, and improve quality of life. Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP(6) + inositol holds great promise in our strategies for cancer prevention and therapy. There is clearly enough evidence to justify the

  17. Gevaar VoIP voor telecomsector overdreven

    NARCIS (Netherlands)

    Deventer, M.O. van; Wegberg, M. van

    2004-01-01

    Het is een hype Voice-over-IP (VoIP) voor te stellen als een ontwrichtende technologie die de telecomindustrie ingrijpend zal veranderen. Maar hoe ontwrichtend is VoIP eigenlijk? Oskar van Deventer en Marc van Wegberg analyseren drie vormen van VoIP en laten zien dat alleen ‘VoIP-chat’ potentieel

  18. Performance analysis and comparison of PTOP and LANE for IP transmission over ATM networks

    Science.gov (United States)

    Zubairi, Junaid A.; Al-Irhayim, Sufyan; Al-Khateeb, Wajdi; Wajdi, Yahya

    1998-12-01

    Due to its traffic control and performance assurance characteristics, ATM is being employed as the core network in most campuses. However, bulk of the workstations remain on Ethernet, generating IP traffic that passes through ATM using special schemes such as PTOP or LANE. In such a network, the performance is affected due to the extra overheads in multiple conversions between cells and packets and managing virtual circuits. The aim of this paper is to compare the performance of PTOP and LANE in passing the IP traffic under various conditions. This study helps in understanding the various performance issues in these environments in order to define the end-to-end quality of service for Ethernet-ATM networks.

  19. Implementation of Reduced Power Open Core Protocol Compliant Memory System using VHDL

    Directory of Open Access Journals (Sweden)

    Ramesh Bhakthavatchalu

    2011-01-01

    Full Text Available The design of a large scale System on Chip (SoC is becoming challenging not only due to the complexity but also due to the use of a large amount of Intellectual Properties (IP. An interface standard for IP cores is becoming important for a successful SoC design. In a SoC the different IP cores are interfaced through different protocols. It increases the complexity of the design. Open Core Protocol (OCP is an openly licensed core centric protocol intended to meet contemporary system level integration challenges. OCP promotes IP core reusability and reduces design time, design risk and manufacturing costs for SoC designs. OCP defines a highly configurable interface including data flow, control, verification and test signals required to describe an IP core's communication. This paper focuses on the design and implementation of a reconfigurable OCP compliant Master Slave interface for a memory system with burst support. The power reduction using Multivoltage design is the important feature of the paper. The proposed design was implemented in VHDL and the Synthesis is done using Synopsys ASIC synthesis tool Design Compiler.

  20. Dynamic IP Reputation from DNS

    Science.gov (United States)

    2016-06-21

    management systems for Internet principals and services – E.g., IP addresses, DNS domains/servers, BGP/AS, etc. – Avoid connections to/from malicious...Operational; data sources for dynamic trust management – Dynamic IP reputation using DNS data 11/4/2009 1 Overview and Motivation • Dynamic Domain...it hosts a few number of bad domains • Ultimate goal: – An on-line dynamic trust/reputation service for IP/Domain 11/4/2009 19 Credits and

  1. Core Quadrant Power Tilt Induced by Control Rods Axial Position Mismatch

    Energy Technology Data Exchange (ETDEWEB)

    Son, Seungbeom; Lee, Changhee; Woo, Haeseuk; Jung, Yilsup [KEPCO Nuclear Fuel, Daejeon (Korea, Republic of); Kim, Yonghee [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)

    2014-05-15

    If the limits are not met, plant operation should be restricted at various conditions. Actually, core quadrant power tilt in many nuclear power plants has been occurred frequently. This study deals with the various general causes of the core quadrant power tilt, including the control rods axial position mismatch induced quadrant power tilt problem. Based on the simulation results in each control rods axial position mismatch in a same control bank, it was found that some control rods axial position mismatch (simply around 10 steps difference) can induce quadrant power tilt relatively high (around 1.5%). With the other causes induced QPT, it may exceed the technical specification limit (2%). So it is needed to drive the control rods in detail during the operation including power change mode.

  2. Chinese massage combined with core stability exercises for nonspecific low back pain: a randomized controlled trial.

    Science.gov (United States)

    Zhang, Yingjie; Tang, Shujie; Chen, Guangmin; Liu, Yuanmei

    2015-02-01

    To determine the effect of Chinese massage combined with core stability exercises on nonspecific low back pain. In the prospective study, ninety-two participants with nonspecific low back pain were divided into experimental and control group at random, and 46 in each. The experimental group were treated using Chinese massage combined with core stability exercises, while the control group were treated using Chinese massage alone. The two groups were evaluated using visual analog scale and Oswestry disability index at baseline, immediately after two and eight weeks. In addition, the recurrence rate of nonspecific low back pain was evaluated one year after the last intervention. Two weeks after treatment, both VAS and ODI scores decreased significantly in two groups (p0.05). Eight weeks later, the VAS and ODI scores decreased significantly in both groups (pCore stability exercises can improve the therapeutic effect of Chinese massage in treating nonspecific low back pain. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. A Framework for Real-Time Resource Allocation in IP Multimedia Subsystem Network

    Directory of Open Access Journals (Sweden)

    Muhammad Naeem

    2013-03-01

    Full Text Available IMS (IP Multimedia Subsystem is designed to provide multiple-services and can be accessed from any access network. With the advent of new multimedia services; user requirement also changed and required delay tolerant services from the service providers. The new multimedia services demands the restrictions on network parameters and this can be achieved by analyzing the traffic flow from the core as well as access network capabilities. As access and core IMS network are independent of each other and does not exchange user SLA with each other. In this paper we proposed framework based on Session border controller (SBC that proactively monitored the traffic statistics as well as interact with access network operator for getting user’s SLA and reserve resources accordingly. We are also proposing alterations in SIP invite and re-invite message to incorporate requested information. These alterations will be useful in ensuring availability of user’s handset capabilities to IMS core network.

  4. Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles

    Science.gov (United States)

    Lio, Daniel; Yeo, David; Xu, Chenjie

    2016-01-01

    Core-shell alginate-poly (lactic-co-glycolic) acid (PLGA) microparticles are potential candidates to improve hydrophilic drug loading while facilitating controlled release. This report studies the influence of the alginate core size on the drug release profile of alginate-PLGA microparticles and its size. Microparticles are synthesized through double-emulsion fabrication via a concurrent ionotropic gelation and solvent extraction. The size of alginate core ranges from approximately 10, 50, to 100 μm when the emulsification method at the first step is homogenization, vortexing, or magnetic stirring, respectively. The second step emulsification for all three conditions is performed with magnetic stirring. Interestingly, although the alginate core has different sizes, alginate-PLGA microparticle diameter does not change. However, drug release profiles are dramatically different for microparticles comprising different-sized alginate cores. Specifically, taking calcein as a model drug, microparticles containing the smallest alginate core (10 μm) show the slowest release over a period of 26 days with burst release less than 1 %.

  5. Qos and Voice Over IP

    Directory of Open Access Journals (Sweden)

    Adrian GHENCEA

    Full Text Available As Voice over Internet Protocol (VoIP technology matures, companies are increasingly adopting it to cut costs, improve efficiency and enhance customer service. Using the Internet as an existing network for integrating data and telecom systems through intelligent VoIP, a range of benefits results: lower long distance costs, cost cuts in cabling processes and more flexible telephony management. However, as voice over IP services grow in popularity, major threats arise: this rapid growth leads to traffic congestion, security is jeopardizedand the poor quality of calls affects communication. The objective of this article is to present all the elements that can affect voicequality in a VoIP network and to provide methods for solving them. A detailed analysis to minimize the impact of implementation of QoS will be made, and at the end solutions to management strategies will be proposed.

  6. Hardware IP security and trust

    CERN Document Server

    Bhunia, Swarup; Tehranipoor, Mark

    2017-01-01

    This book provides an overview of current Intellectual Property (IP) based System-on-Chip (SoC) design methodology and highlights how security of IP can be compromised at various stages in the overall SoC design-fabrication-deployment cycle. Readers will gain a comprehensive understanding of the security vulnerabilities of different types of IPs. This book would enable readers to overcome these vulnerabilities through an efficient combination of proactive countermeasures and design-for-security solutions, as well as a wide variety of IP security and trust assessment and validation techniques. This book serves as a single-source of reference for system designers and practitioners for designing secure, reliable and trustworthy SoCs.

  7. Controlled mixing of lanthanide(III) ions in coacervate core micelles.

    Science.gov (United States)

    Wang, Junyou; Velders, Aldrik H; Gianolio, Eliana; Aime, Silvio; Vergeldt, Frank J; Van As, Henk; Yan, Yun; Drechsler, Markus; de Keizer, Arie; Cohen Stuart, Martien A; van der Gucht, Jasper

    2013-05-01

    This article presents a facile strategy to combine Eu(3+) and Gd(3+) ions into coacervate core micelles in a controlled way with a statistical distribution of the ions. Consequently, the formed micelles show a high tunability between luminescence and relaxivity. These highly stable micelles present great potential for new materials, e.g. as bimodal imaging probes.

  8. Real-Time Control of Embedded Device Based on Private IP Address in Internet%私有IP地址环境中的嵌入式设备实时控制技术研究

    Institute of Scientific and Technical Information of China (English)

    兰勇; 张博

    2011-01-01

    Aiming at the inconsistency between rapid increase of device join to Internet for communication and the shortage of IP addresses in Internet, a remote control method of embedded device based on private IP address in Internet is proposed. The structure of the control system based on client/server is given for embedded device, which could be online by technology of connection oriented. The application results show that this control method has perfect performances, such as high reliability, plug and play, extended functions, etc. Furthermore, this method can provide technical support during the design and building Internet of things.%针对Intemet数据通信所面临的设备公有IP地址匮乏的事实,设计了一种基于私有IP地址的嵌入式设备接入Intemet实施远程控制的技术.通过构建基于客户/服务器的集中式控制体系结构,实现了嵌入式设备面向连接的实时在线技术,从而实现了基于Intemet的实时控制.实际应用验证该技术具有实时性强、即插即用和设备扩展性好等特性.该技术同时为基于Internet构建物联网提供了良好的技术支持.

  9. VoIP Forensic Analyzer

    Directory of Open Access Journals (Sweden)

    M Mohemmed Sha

    2016-01-01

    Full Text Available People have been utilizing Voice over Internet Protocol (VoIP in most of the conventional communication facilities which has been of assistance in the enormous attenuation of operating costs, as well as the promotion of next- generation communication services-based IP. As an intimidating upshot, cyber criminals have correspondingly started interjecting the environment and creating new challenges for the law enforcement system in any Country. This paper presents an idea of a framework for the forensic analysis of the VoIP traffic over the network. This forensic activity includes spotting and scrutinizing the network patterns of VoIP-SIP stream, which is used to initiate a session for the communication, and regenerate the content from VoIP-RTP stream, which is employed to convey the data. Proposed network forensic investigation framework also accentuates on developing an efficient packet restructuring algorithm for tracing the depraved users involved in a conversation. Network forensics is the basis of proposed work, and performs packet level surveillance of VoIP followed by reconstruction of original malicious content or network session between users for their prosecution in the court.

  10. The importance of sensory-motor control in providing core stability: implications for measurement and training.

    Science.gov (United States)

    Borghuis, Jan; Hof, At L; Lemmink, Koen A P M

    2008-01-01

    Although the hip musculature is found to be very important in connecting the core to the lower extremities and in transferring forces from and to the core, it is proposed to leave the hip musculature out of consideration when talking about the concept of core stability. A low level of co-contraction of the trunk muscles is important for core stability. It provides a level of stiffness, which gives sufficient stability against minor perturbations. Next to this stiffness, direction-specific muscle reflex responses are also important in providing core stability, particularly when encountering sudden perturbations. It appears that most trunk muscles, both the local and global stabilization system, must work coherently to achieve core stability. The contributions of the various trunk muscles depend on the task being performed. In the search for a precise balance between the amount of stability and mobility, the role of sensory-motor control is much more important than the role of strength or endurance of the trunk muscles. The CNS creates a stable foundation for movement of the extremities through co-contraction of particular muscles. Appropriate muscle recruitment and timing is extremely important in providing core stability. No clear evidence has been found for a positive relationship between core stability and physical performance and more research in this area is needed. On the other hand, with respect to the relationship between core stability and injury, several studies have found an association between a decreased stability and a higher risk of sustaining a low back or knee injury. Subjects with such injuries have been shown to demonstrate impaired postural control, delayed muscle reflex responses following sudden trunk unloading and abnormal trunk muscle recruitment patterns. In addition, various relationships have been demonstrated between core stability, balance performance and activation characteristics of the trunk muscles. Most importantly, a significant

  11. NOVEL APPROACH TO RESOLVE NETWORK SECURITY ISSUES IN IP-PBX IN CONVERGED ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    MUNIR B. SAYYAD,

    2010-10-01

    Full Text Available This paper aims to examine the security issues in the IP-PBX (IP Private Branch Exchange .The Traces are taken on the live environment using Vendor ‘X’ CDMA MSC. The traces are also taken at SBC (Session Boarder Controller. The PBX services can be provided over IP via a SIP (session initiation protocol trunk provided by network operator. The SIP trunk is connected to a switch i.e. MSC. Thus IP connectivity is available at IP-PBX end. Now calls can be originated from IP-PBX which is terminating on a mobile handset registered with MSC. The problem arises when a dummy/blank/fake CLI (caller line identification is configured at IP-PBX. As MSC isdoing only part of routing depending upon called party number, such calls with fake CLI pass through MSC without any intervention. So called party and even MSC are unaware of real number of calling party. Similar security issue arises when IP-PBX sends dummy IP addresses of IP phones connected to IP-PBX. Thus conflict of IP addresses and or called party numbers creates a major security concern. These are important issues for interfacing IP with traditional wire line or wireless network. Such a security issue can be resolved by registering IP-PBX and its extension numbers with MSC. This paper describes the probable methods to resolve above issues.

  12. Impact of the control rod consumption on the reactivity control of a SFR break-even core

    Energy Technology Data Exchange (ETDEWEB)

    Blanchet, D.; Fontaine, B. [CEA, DEN, SPRC, Cadarache, F-13108 Cedex Saint-Paul-lez-Durance (France)

    2012-07-01

    Current design studies on Sodium Fast Reactor (SFR) differ from those performed in the past by the fact that design criteria are now those of the Generation IV reactors. In order to improve their safety, reactors with break-even cores are preferred because they minimize the needs in terms of reactivity control and limit the consequences of control rod withdrawal. Furthermore, as the reactivity control needs are low, break-even core enables the use of absorbing materials with reduced efficiency (natural boron, hafnium...). Nevertheless, the use of control rods with few absorbing materials may present the disadvantage of a non-negligible ({approx}10%) loss of efficiency due to their consumption under irradiation. This paper presents a methodology to calculate accurately and analyze this consumption. (authors)

  13. Unlocking the Physiochemical Controls on Organic Carbon Dynamics from the Soil Pore- to Core-Scale

    Science.gov (United States)

    Smith, A. P.; Tfaily, M. M.; Bond-Lamberty, B. P.; Todd-Brown, K. E.; Bailey, V. L.

    2015-12-01

    The physical organization of soil includes pore networks of varying size and connectivity. These networks control microbial access to soil organic carbon (C) by spatially separating microorganisms and C by both distance and size exclusion. The extent to which this spatially isolated C is vulnerable to microbial transformation under hydrologically dynamic conditions is unknown, and limits our ability to predict the source and sink capacity of soils. We investigated the effects of shifting hydrologic connectivity and soil structure on greenhouse gas C emissions from surface soils collected from the Disney Wilderness Preserve (Florida, USA). We subjected intact soil cores and re-packed homogenized soil cores to simulated groundwater rise or precipitation, monitoring their CO2 and CH4 emissions over 24 hours. Soil pore water was then extracted from each core using different suctions to sample water retained by pore throats of different sizes and then characterized by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. Greater respiration rates were observed from homogenized cores compared to intact cores, and from soils wet from below, in which the wetting front is driven by capillary forces, filling fine pores first. This suggests that C located in fine pores may turn over via diffusion processes that lead to the colocation of this C with other resources and microorganisms. Both the complexity and concentration of soluble-C increased with decreasing pore size domains. Pore water extracted from homogenized cores had greater C concentrations than from intact cores, with the greatest concentrations in pore waters sampled from very fine pores, highlighting the importance of soil structure in physically protecting C. These results suggest that the spatial separation of decomposers from C is a key mechanism stabilizing C in these soils. Further research is ongoing to accurately represent this protection mechanism, and the conditions under which it breaks

  14. Controlled Growth of Ordered III-Nitride Core-Shell Nanostructure Arrays for Visible Optoelectronic Devices

    Science.gov (United States)

    Rishinaramangalam, Ashwin K.; Ul Masabih, Saadat Mishkat; Fairchild, Michael N.; Wright, Jeremy B.; Shima, Darryl M.; Balakrishnan, Ganesh; Brener, Igal; Brueck, S. R. J.; Feezell, Daniel F.

    2015-05-01

    We demonstrate the growth of ordered arrays of nonpolar core-shell nanowalls and semipolar core-shell pyramidal nanostripes on c-plane (0001) sapphire substrates using selective-area epitaxy and metal organic chemical vapor deposition. The nanostructure arrays are controllably patterned into LED mesa regions, demonstrating a technique to impart secondary lithography features into the arrays. We study the dependence of the nanostructure cores on the epitaxial growth conditions and show that the geometry and morphology are strongly influenced by growth temperature, V/III ratio, and pulse interruption time. We also demonstrate the growth of InGaN quantum well shells on the nanostructures and characterize the structures by using micro-photoluminescence and cross-section scanning tunneling electron microscopy.

  15. 车载话音集中控制器中VoIP网关技术实现%VoIP Gateway Technology for Vehicle-Borne Voice Centralized Controller

    Institute of Scientific and Technical Information of China (English)

    李志国; 李乔

    2012-01-01

    介绍了车载话音集中控制器的整体设计及其IP电话(V oIP)联网总体构成。从V oIP网关的话音模式、录音管理以及消息转发机制角度,阐述了V oIP网关设计。通过车载话音控制器完成了野战地域网与无线网络的互连互通,增强了指挥调度能力。%The overall design of the vehicle-borne voice centralized controller and the general voice over internet protocol (VoIP) networking is described. The VoIP gateway design is illustrated from the voice mode of the VoIP gateway, the recording management and the message forwarding mechanism. Experimental results show that the vehicle-borne voice centralized controller can en- able the interconnection between the field data communication network and the wireless network, thus enhancing command and dispatching capabilities.

  16. 高可靠性微控制器设计研究%Research on High-Dependability Micro-controller IP Core Design

    Institute of Scientific and Technical Information of China (English)

    谈荒; 邱跃洪; 陈智

    2009-01-01

    本文目标是根据航天电子设计的需要,提出一种高可靠性微处理器设计的设计方案.在分析了单粒子效应的和总结了高可靠性设计技术的基础上,对oregano systems公司提供的mc8051IP软核进行了修改.修改后的IP核满足设计要求,运行稳定,最终实验结果说明:设计方案合理,实现简单,具备实用价值.

  17. A Distributed IP-Based Telecommunication System using SIP

    Directory of Open Access Journals (Sweden)

    Carlton Andre Thompson

    2013-11-01

    Full Text Available Voice over Internet Protocol (VoIP technologies are integral to modern telecommunications because oftheir advanced features, flexibility, and economicbenefits. Internet Service Providers initially promotedthese technologies by providing low cost local andinternational calling. At present, there is also agreatdeal of interest in using IP-based technologies toreplace traditional small and large office telephonesystems that use traditional PBX’s (Private BrancheXchange. Unfortunately, the large majority of theemerging VoIP based office telephone systems have followed the centralized design of traditional publicand private telephone systems in which all the intelligence in the system is at the core, with quite expensivehardware and software components and appropriate redundancy for adequate levels of reliability. In thispaper, it is argued that a centralized model for anIP-based telecommunications system fails to exploit thefull capabilities of Internet-inspired communications and that, very simple, inexpensive, elegant andflexible solutions are possible by deliberately avoiding the centralized approach. This paper describes thedesign, philosophy and implementation of a prototype for a fully distributed IP-based TelecommunicationSystem (IPTS that provides the essential feature set for office and home telecommunications, including IP-based long-distance and local calling, and with thesupport for video as well as data and text. Theprototype system was implemented with an Internet-inspired distributed design using open source software,with appropriate customizations and configurations.

  18. Controllable core-shell-type resin for solid-phase peptide synthesis.

    Science.gov (United States)

    Cho, Hong-Jun; Lee, Tae-Kyung; Kim, Jung Won; Lee, Sang-Myung; Lee, Yoon-Sik

    2012-10-19

    A simple, mild, and inexpensive biphasic functionalization approach is attempted for preparing an ideal core-shell-type resin. The core-shell-type architecture was constructed by coupling Fmoc-OSu to the amino groups on the shell layer of an aminomethyl polystyrene (AM PS) resin. The shell layer thickness of the resin could be easily controlled under mild conditions, which was characterized by confocal laser scanning microscopy (CLSM). The efficiency of core-shell-type resin for solid-phase peptide synthesis (SPPS) was demonstrated by the synthesis of various peptides and compared with commercially available noncore-shell-type resins such as AM PS and poly(ethylene glycol)-based resins. The core-shell-type resin provided effective performance during the synthesis of hydrophobic peptide sequences, a disulfide-bridged cyclic peptide, and a difficult PNA sequence. Furthermore, a highly aggregative peptide fragment, MoPrP 105-125, was synthesized more efficiently on the core-shell-type resin under microwave conditions than AM PS and ChemMatrix resins.

  19. A Testbed For Validating the LHC Controls System Core Before Deployment

    CERN Document Server

    Nguyen Xuan, J

    2011-01-01

    Since the start-up of the LHC, it is crucial to carefully test core controls components before deploying them operationally. The Testbed of the CERN accelerator controls group was developed for this purpose. It contains different hardware (PPC, i386) running various operating systems (Linux and LynxOS) and core software components running on front-ends, communication middleware and client libraries. The Testbed first executes integration tests to verify that the components delivered by individual teams interoperate, and then system tests, which verify high-level, end-user functionality. It also verifies that different versions of components are compatible, which is vital, because not all parts of the operational LHC control system can be upgraded simultaneously. In addition, the Testbed can be used for performance and stress tests. Internally, the Testbed is driven by Atlassian Bamboo, a Continuous Integration server, which builds and deploys automatically new software versions into the Test...

  20. Interfacing the Controllogics PLC over Ethernet/IP.

    Energy Technology Data Exchange (ETDEWEB)

    Kasemir, K. U. (Kay-Uwe); Dalesio, L. R. (Leo R.)

    2001-01-01

    The Allen-Bradley ControlLogix [1] line of programmable logic controllers (PLCs) offers several interfaces: Ethernet, ControlNet, DeviceNet, RS-232 and others. The ControlLogix Ethernet interface module 1756-ENET uses EtherNet/IP, the ControlNet protocol [2], encapsulated in Ethernet packages, with specific service codes [3]. A driver for the Experimental Physics and Industrial Control System (EPICS) has been developed that utilizes this EtherNet/IP protocol for controllers running the vxWorks RTOS as well as a Win32 and Unix/Linux test program. Features, performance and limitations of this interface are presented.

  1. An extra-domiciliary method of delivering entomopathogenic fungus, Metharizium anisopliae IP 46 for controlling adult populations of the malaria vector, Anopheles arabiensis

    Directory of Open Access Journals (Sweden)

    Mnyone Ladslaus L

    2010-03-01

    Full Text Available Abstract Fungal biopesticides have the potential to significantly reduce densities of malaria vectors as well as associated malaria transmission. In previous field trials, entomopathogenic fungus was delivered from within human dwellings, where its efficacy was limited by low infection rates of target mosquitoes, high costs of spraying fungus inside houses, and potential public health concerns associated with introducing fungal conidia inside houses. Here we have demonstrated that Metarhizium anisopliae IP 46, delivered within an extra-domiciliary odor-baited station (OBS, can infect and slowly-kill a high proportion of the wild adult malaria vector, Anopheles arabiensis which entered and exited the OBS. This study, carried out in rural Tanzania, showed that by using a concentration of 3.9 × 1010 conidia/m2, more than 95% of mosquitoes that flew in and out of the OBS died within 14 days post-exposure. At least 86% infection of mosquito cadavers was recorded with a significant reduction in the probability of daily survival of exposed An. arabiensis in both treatments tested: low quantity of conidia (eave baffles plus one cotton panel; HR = 2.65, P P

  2. Accurate core position control in polymer optical waveguides using the Mosquito method for three-dimensional optical wiring

    Science.gov (United States)

    Date, Kumi; Ishigure, Takaaki

    2017-02-01

    Polymer optical waveguides with graded-index (GI) circular cores are fabricated using the Mosquito method, in which the positions of parallel cores are accurately controlled. Such an accurate arrangement is of great importance for a high optical coupling efficiency with other optical components such as fiber ribbons. In the Mosquito method that we developed, a core monomer with a viscous liquid state is dispensed into another liquid state monomer for cladding via a syringe needle. Hence, the core positions are likely to shift during or after the dispensing process due to several factors. We investigate the factors, specifically affecting the core height. When the core and cladding monomers are selected appropriately, the effect of the gravity could be negligible, so the core height is maintained uniform, resulting in accurate core heights. The height variance is controlled in +/-2 micrometers for the 12 cores. Meanwhile, larger shift in the core height is observed when the needle-tip position is apart from the substrate surface. One of the possible reasons of the needle-tip height dependence is the asymmetric volume contraction during the monomer curing. We find a linear relationship between the original needle-tip height and the core-height observed. This relationship is implemented in the needle-scan program to stabilize the core height in different layers. Finally, the core heights are accurately controlled even if the cores are aligned on various heights. These results indicate that the Mosquito method enables to fabricate waveguides in which the cores are 3-dimensionally aligned with a high position accuracy.

  3. Assessment of the control rods shadow effect in the VENUS-F core

    Directory of Open Access Journals (Sweden)

    Cetnar Jerzy

    2014-12-01

    Full Text Available The partitioning and transmutation (P&T of spent nuclear fuel is an important field of present development of nuclear energy technologies. One of the possible ways to carry out the P&T process is to use the accelerator driven systems (ADS. This technology has been developed within the EURATOM Framework Programmes for several years now. Current research in this field is carried out within the scope of 7th FP project FREYA. Important parts of the project are experiments performed in the GUINEVERE facility devoted to characterising the subcritical core kinetics and development of reactivity monitoring techniques. The present paper considers the effects of control rods use on the core reactivity. In order to carry out the evaluation of the experimental results, it is important to have detailed core characteristics at hand and to take into consideration the differences in the effect of control rods acting separately or together (the so-called shadow effect on both the reactivity value and the measured neutron flux. Also any core asymmetry should be revealed. This goal was achieved by both MCNP simulations and the experimental results. However, in the case of experimental results, the need for calculating respective correction factors was unavoidable.

  4. Steganography of VoIP streams

    CERN Document Server

    Mazurczyk, Wojciech

    2008-01-01

    In this paper, we circumscribe available steganographic techniques that can be used for creating covert channels for VoIP (Voice over Internet Protocol) streams. Apart from characterizing existing steganographic methods we provide new insights by presenting two new techniques. First one is network steganography solution and exploits free/unused fields of the RTCP (Real-Time Control Protocol) and RTP (Real-Time Transport Protocol) protocols. The second method provides hybrid storage-timing covert channel by utilizing delayed audio packets. The results of the experiment, that was performed, regardless of steganalysis, to estimate a total amount of data that can be covertly transferred in VoIP RTP stream during the typical call, are also included in this article.

  5. Complexes of myo-Inositol-Hexakisphosphate (IP6) with Zinc or Lanthanum for the Decorporation of Radiocesium.

    Science.gov (United States)

    Ogawa, Kazuma; Aoki, Miho; Fukuda, Tadahisa; Kadono, Sumi; Kiwada, Tatsuto; Odani, Akira

    2017-01-01

    Radioactive nuclides leak into the surrounding environment after nuclear power plant disasters, such as the Chernobyl accident and the Fukushima Daiichi Nuclear Power Plant disaster. Cesium-137 ((137)Cs) (t1/2=30.1 year), a water-soluble radionuclide with a long physical half-life, contaminates aquatic ecosystems and food products. In humans, (137)Cs concentrates in muscle tissue and has a long biological half-life, indicating it may be harmful. myo-Inositol-hexakisphosphate (IP6) is a compound found in grain, beans, and oil seeds. IP6 has the ability to form insoluble complexes with metals, including lanthanum (La) and zinc (Zn). We hypothesized that La-IP6 and Zn-IP6 may promote the elimination of (137)Cs from the body through the adsorption of La-IP6 and Zn-IP6 to (137)Cs in the gastrointestinal tract. Therefore, in this study, we evaluated the adsorptive capacity of La-IP6 and Zn-IP6 complexes with (137)Cs in vitro and in vivo. La-IP6 and Zn-IP6 complexes were stable in acidic solution (pH 1.2) at 37°C. In vitro binding assays indicated that La-IP6 and Zn-IP6 complexes adsorbed (137)Cs, with the adsorption capacity of Zn-IP6 to (137)Cs greater than that of La-IP6. To evaluate the usefulness of La-IP6 and Zn-IP6 in vivo, La-IP6 or Zn-IP6 was administrated to mice after intravenous injection of (137)Cs. However, the biodistribution of (137)Cs in the La-IP6 treated group and the Zn-IP6 treated group was nearly identical to the non-treated control group, indicating that La-IP6 and Zn-IP6 were not effective at promoting the elimination of (137)Cs in vivo.

  6. PAtCh-Cap: input strategy for improving analysis of ChIP-exo data sets and beyond

    Science.gov (United States)

    Terooatea, Tommy W.; Pozner, Amir; Buck-Koehntop, Bethany A.

    2016-01-01

    Recently, a number of advances have been implemented into the core ChIP-seq (chromatin immunoprecipitation coupled with next-generation sequencing) methodology to streamline the process, reduce costs or improve data resolution. Several of these emerging ChIP-based methods perform additional chemical steps on bead-bound immunoprecipitated chromatin, posing a challenge for generating similarly treated input controls required for artifact removal during bioinformatics analyses. Here we present a versatile method for producing technique-specific input controls for ChIP-based methods that utilize additional bead-bound processing steps. This reported method, termed protein attached chromatin capture (PAtCh-Cap), relies on the non-specific capture of chromatin-bound proteins via their carboxylate groups, leaving the DNA accessible for subsequent chemical treatments in parallel with chromatin separately immunoprecipitated for the target protein. Application of this input strategy not only significantly enhanced artifact removal from ChIP-exo data, increasing confidence in peak identification and allowing for de novo motif searching, but also afforded discovery of a novel CTCF binding motif. PMID:27550178

  7. Mobility management in mobile IP

    Science.gov (United States)

    Medidi, Sirisha; Golshani, Forouzan

    2002-07-01

    There is an emerging interest in integrating mobile wireless communication with the Internet based on the Ipv6 technology. Many issues introduced by the mobility of users arise when such an integration is attempted. This paper addresses the problem of mobility management, i.e., that of tracking the current IP addresses of mobile terminals and sustaining active IP connections as mobiles move. The paper presents some architectural and mobility management options for integrating wireless access to the Internet. We then present performance results for Mobile IPv4, route optimization and Mobile IPv6.

  8. Security Risks in IP Telephony

    Directory of Open Access Journals (Sweden)

    Filip Rezac

    2010-01-01

    Full Text Available This paper deals with VoIP communication security and various techniques of VoIP attacks. We divided these threats in several categories according to their specific behaviour and their impact on the affected system. We also tried to find effective methods to prevent or mitigate these attacks. We focused our work on Spam over Internet Telephony (SPIT as a real threat for the future. We have developed both a tool generating SPIT attacks and AntiSPIT tool defending communication systems against SPIT attacks. AntiSPIT represents an effective protection based on statistical blacklist and works without participation of the called party which is a significant advantage.

  9. Titanium carbide@polypyrrole core-shell nanoparticles prepared by controlled heterogeneous nucleation for rechargeable batteries.

    Science.gov (United States)

    Weng, Yu-Ting; Wu, Nae-Lih

    2013-11-28

    A unique nanostructure consisting of a TiC nanoparticle core and a conformal polypyrrole shell doped with p-toluene sulfonate has been synthesized by a controlled heterogeneous nucleation process. As an electrode material in a Li-ion containing organic electrolyte, the nanocomposite exhibits remarkable high-rate (up to 400 C-rate) charge-discharge capability and cycling stability even at 50 °C.

  10. Congestion Avoidance in IP Based CDMA Radio Access Network

    Directory of Open Access Journals (Sweden)

    Syed Shakeel Hashmi

    2011-02-01

    Full Text Available CDMA is an important air interface technologies for cellular wireless networks. As CDMAbasedcellular networks mature, the current point-to-point links will evolve to an IP-based Radio AccessNetwork (RAN. mechanisms must be designed to control the IP Radio Access Network congestion.This Paper implements a congestion control mechanism using Router control and channelcontrol method for IP-RAN on CDMA cellular network. The Router control mechanism uses the featuresof CDMA networks using active Queue Management technique to reduce delay and to minimize thecorrelated losses. The Random Early Detection Active Queue Management scheme (REDAQM is to berealized for the router control for data transmission over the radio network using routers as the channel.The channel control mechanism control the congestion by bifurcating the access channel into multiplelayer namely RACH, BCCH and DCH for data accessing. The proposed paper work is realized usingMatlab platform.

  11. NEW ARCHITECTURE OF IP QOS MANAGEMENT SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Jiao Li; Cui Yidong; Lin Yu; Wang Wendong; Cheng Shiduan

    2006-01-01

    Based on the analysis of current Quality of Service (QoS) management on IP network, new generation of QoS architecture QoSAF is proposed. QoSAF is divided into three layers: resource control layer, network service layer and business layer. QoS management is accomplished by interactivity of layers. In this architecture, mechanism of feedback control enhances the functions of resource management and system monitoring. The principle of design and logical architecture of system is discussed in detail.

  12. Charge State of the Globular Histone Core Controls Stability of the Nucleosome

    Science.gov (United States)

    Fenley, Andrew T.; Adams, David A.; Onufriev, Alexey V.

    2010-01-01

    Presented here is a quantitative model of the wrapping and unwrapping of the DNA around the histone core of the nucleosome that suggests a mechanism by which this transition can be controlled: alteration of the charge state of the globular histone core. The mechanism is relevant to several classes of posttranslational modifications such as histone acetylation and phosphorylation; several specific scenarios consistent with recent in vivo experiments are considered. The model integrates a description based on an idealized geometry with one based on the atomistic structure of the nucleosome, and the model consistently accounts for both the electrostatic and nonelectrostatic contributions to the nucleosome free energy. Under physiological conditions, isolated nucleosomes are predicted to be very stable (38 ± 7 kcal/mol). However, a decrease in the charge of the globular histone core by one unit charge, for example due to acetylation of a single lysine residue, can lead to a significant decrease in the strength of association with its DNA. In contrast to the globular histone core, comparable changes in the charge state of the histone tail regions have relatively little effect on the nucleosome's stability. The combination of high stability and sensitivity explains how the nucleosome is able to satisfy the seemingly contradictory requirements for thermodynamic stability while allowing quick access to its DNA informational content when needed by specific cellular processes such as transcription. PMID:20816070

  13. IP3 receptors regulate vascular smooth muscle contractility and hypertension

    Science.gov (United States)

    Lin, Qingsong; Zhao, Guiling; Fang, Xi; Peng, Xiaohong; Tang, Huayuan; Wang, Hong; Jing, Ran; Liu, Jie; Ouyang, Kunfu

    2016-01-01

    Inositol 1, 4, 5-trisphosphate receptor–mediated (IP3R-mediated) calcium (Ca2+) release has been proposed to play an important role in regulating vascular smooth muscle cell (VSMC) contraction for decades. However, whether and how IP3R regulates blood pressure in vivo remains unclear. To address these questions, we have generated a smooth muscle–specific IP3R triple-knockout (smTKO) mouse model using a tamoxifen-inducible system. In this study, the role of IP3R-mediated Ca2+ release in adult VSMCs on aortic vascular contractility and blood pressure was assessed following tamoxifen induction. We demonstrated that deletion of IP3Rs significantly reduced aortic contractile responses to vasoconstrictors, including phenylephrine, U46619, serotonin, and endothelin 1. Deletion of IP3Rs also dramatically reduced the phosphorylation of MLC20 and MYPT1 induced by U46619. Furthermore, although the basal blood pressure of smTKO mice remained similar to that of wild-type controls, the increase in systolic blood pressure upon chronic infusion of angiotensin II was significantly attenuated in smTKO mice. Taken together, our results demonstrate an important role for IP3R-mediated Ca2+ release in VSMCs in regulating vascular contractility and hypertension.

  14. TCP-IP Model in Data Communication and Networking

    OpenAIRE

    Pranab Bandhu Nath; Md.Mofiz Uddin

    2015-01-01

    The Internet protocol suite is the computer networking model and set of communications protocols used on the Internet and similar computer networks. It is commonly known as TCP/IP, because it’s most important protocols, the Transmission Control Protocol (TCP) and the Internet Protocol (IP), were the first networking protocols defined in this standard. Often also called the Internet model, it was originally also known as the DoD model, because the development of the networking mode...

  15. Research on Performance between IP and Vector Forwarding

    Directory of Open Access Journals (Sweden)

    Aqun Zhao

    2013-03-01

    Full Text Available With the rapid development of network size and great increase of Internet traffic, it has become a crucial work to improve the forwarding performance of the core devices of Internet or the routers. In this study, the analysis and comparison of instruction cycles occupied by the machine in the process of route lookup in IP forwarding and vector forwarding were carried out which may determine the forwarding performance of a router. The simulation experiments were also made to study the forwarding efficiency of IP forwarding and vector forwarding. The theoretical and experimental results prove that the vector forwarding method is more efficient than IP forwarding which can provide powerful evidence to the application of vector network in the Internet.

  16. Continuously Connected With Mobile IP

    Science.gov (United States)

    2002-01-01

    Cisco Systems developed Cisco Mobile Networks, making IP devices mobile. With this innovation, a Cisco router and its connected IP devices can roam across network boundaries and connection types. Because a mobile user is able to keep the same IP address while roaming, a live IP connection can be maintained without interruption. Glenn Research Center jointly tested the technology with Cisco, and is working to use it on low-earth-orbiting research craft. With Cisco's Mobile Networks functionality now available in Cisco IOS Software release 12.2(4)T, the commercial advantages and benefits are numerous. The technology can be applied to public safety, military/homeland security, emergency management services, railroad and shipping systems, and the automotive industry. It will allow ambulances, police, firemen, and the U.S. Coast Guard to stay connected to their networks while on the move. In the wireless battlefield, the technology will provide rapid infrastructure deployment for U.S. national defense. Airline, train, and cruise passengers utilizing Cisco Mobile Networks can fly all around the world with a continuous Internet connection. Cisco IOS(R) Software is a registered trademark of Cisco Systems.

  17. A policy-based billing management architecture for the next generation IP-based network

    Institute of Scientific and Technical Information of China (English)

    Cheng Lu; Qiu Xuesong; Meng Luoming

    2006-01-01

    IP billing is not only a basic functionality to operate IP services, but also it is fundamental to offer customers with a stable and QoS-enabled network environment. As IP-based network has been widely agreed to be the core network of NGN, and existing IP billing system is too simple to fulfill the emerging requirements, the next generation IP billing has become an interesting topic in recent years. Policy-based management brings flexibility and scalability to systems by describing management logic and functions through policies, and thus reduces the complexity of the management of large-scale systems. Working on existing efforts, this paper proposed an improved IETF policy framework based upon which a policy-based billing management architecture for the next generation IP-based network was presented. Then a prototype with some basic functionalities was developed. The results of the experiment validated the expected improvements specified in this paper.

  18. Controlled immobilization of palladium nanoparticles in two different fluorinated polymeric aggregate cores and their application in catalysis

    DEFF Research Database (Denmark)

    Kijima, Tetsushi; Javakhishvili, Irakli; Jankova Atanasova, Katja

    2012-01-01

    ,3,4,5,6-pentafluorostyrene)-containing ABA-triblock copolymeric nanocomposites-immobilized palladium nanoparticles were prepared by the use of the corresponding block copolymers under similar conditions. TEM images showed that palladium nanoparticles can be immobilized outside the fluorinated cooligomeric nanocomposite...... cores; in contrast, palladium nanoparticles can be effectively immobilized inside these fluorinated ABA-triblock copolymeric nanocomposite cores. Thus, these two different fluorinated copolymers enabled the controlled immobilization of palladium nanoparticles in the fluorinated nanocomposite cores...

  19. Evaluation of Heat Removal from RBMK-1500 Core Using Control Rods Cooling Circuit

    Directory of Open Access Journals (Sweden)

    A. Kaliatka

    2008-01-01

    Full Text Available The Ignalina nuclear power plant is a twin unit with two RBMK-1500, graphite moderated, boiling water, multichannel reactors. After the decision was made to decommission the Ignalina NPP, Unit 1 was shut down on December 31, 2004, and Unit 2 is to be operated until the end of 2009. Despite of this fact, severe accident management guidelines for RBMK-1500 reactor at Ignalina NPP are prepared. In case of beyond design basis accidents, it can occur that no water sources are available at the moment for heat removal from fuel channels. Specificity of RBMK reactor is such that the channels with control rods are cooled with water supplied by the system totally independent from the reactor cooling system. Therefore, the heat removal from RBMK-1500 reactor core using circuit for cooling of rods in control and protection system can be used as nonregular mean for reactor cooldown in case of BDBA. The heat from fuel channels, where heat is generated, through graphite bricks is transferred in radial direction to cooled CPS channels. This article presents the analysis of possibility to remove heat from reactor core in case of large LOCA by employing CPS channels cooling circuit. The analysis was performed for Ignalina NPP with RBMK-1500 reactor using RELAP5-3D and RELAP5 codes. Results of the analysis have shown that, in spite of high thermal inertia of graphite, this heat removal from CPS channels allows to slow down effectively the core heat-up process.

  20. Control of Saturation level in the magnetic core of a welding transformer by Hysteresis Controller (HC and Proportional Integral (PI Controller

    Directory of Open Access Journals (Sweden)

    Rama Subbanna.S

    2016-12-01

    Full Text Available The objective of this paper is to analyse the performances of two controllers such as Hysteresis control (HC and proportional integral (PI control to control saturation level in the magnetic core of a welding transformer in a middle-frequency direct current (MFDC resistance spot welding system(RSWS. It consists of an input converter, welding transformer, and a full-wave rectifier mounted at the transformer secondary. The unequal ohmic resistances of the two transformer’s secondary circuits and the different characteristics of the diodes of output rectifier certainly lead to the magnetic core saturation which, consequently, causes the unwanted spikes in the transformer’s primary current and over-current protection switch-off. The goal is to analyse the performance of both controllers in terms of transients, total harmonic distortion(THD and variations in primary current and flux in the magnetic core of a welding transformer of highly nonlinear system of RSWS. The simulation study has been done in Matlab/Simulink environment and presented performance analysis. The responses shows that from the aforementioned aspects, proportional integral Controller is the better choice for controlling the saturation level in magnetic core of a welding transformer which is widely used in automobile industry welding system.

  1. Core competencies to prevent and control chronic diseases of Tambol Health Centers' head in Thailand.

    Science.gov (United States)

    Leerapan, Prasit; Kengganpanich, Tharadol; Sompopcharoen, Malinee

    2012-06-01

    To assess the core competencies to prevent and control chronic diseases of the head of Tambol Health Centers (THC) in Thailand. This cross-sectional survey research was carried out with 2,049 heads of THC from the total population of 9,985. The samples were selected randomly from all provinces of every region. The data were collected through mail questionnaires and the reliability values of the three competency domains questionnaire were found to be between 0.75-0.93. Data analysis was done by computing frequency, percentage, arithmetic mean, Independent's t-test and One-way ANOVA. The total core competency values of prevention and control of diabetes and hypertension of the THC heads were found at the high and moderate level (3.0% and 78.7%) respectively The similar finding was found in the competency domains in regard to "personal attribution", "intellectual capacity" while 8.0 percent and 46.2 percent of the respondents had the high and moderate level of "work skill" domain respectively. In addition, the differences of competency domains were found in accordance with the regions where the THC located, ability to develop a plan for disease prevention and readiness for changing behaviors of the risk groups. But the personal attributions with regard to gender age, family's economic status, and the location of the THC were not found to affect every competency domain. Except for the intellectual capacity domain found that the male THC heads had the higher level than the females and work skill domain of those THC heads working in the municipal areas had the higher level than those who worked outside the municipal areas. Core competencies of the heads of THC in chronic disease prevention and control were found at the "somewhat good" level except for the work skill domain which needed to be developed. Thus, the Ministry of Public Health should establish a specific policy and strategy on human resource development by using core competencies on chronic disease prevention

  2. Validity and reliability of the proposed core competency for infection control nurses of hospitals in Hong Kong.

    Science.gov (United States)

    Chan, Wai Fong; Adamson, Bob; Chung, Joanne W Y; Chow, Meyrick C M

    2011-04-01

    Literature review and the Delphi approach were used to draft the core competency items of hospital infection control nurses in Hong Kong. Content validity, internal consistency, and test-retest reliability of the proposed core competency were ensured. The result serves as the foundation of developing training and assessment tools for infection control nurses in Hong Kong. Copyright © 2011 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

  3. Electrically-responsive core-shell hybrid microfibers for controlled drug release and cell culture.

    Science.gov (United States)

    Chen, Chuntao; Chen, Xiao; Zhang, Heng; Zhang, Qi; Wang, Li; Li, Chenxi; Dai, Beibei; Yang, Jiazhi; Liu, Jian; Sun, Dongping

    2017-06-01

    It is an active research field to develop fiber-shaped smart materials for biomedical applications. Here we report the development of the multifunctional core-shell hybrid microfibers with excellent mechanical and electrical performance as a new smart biomaterial. The microfibers were synthesized using a combination of co-axial spinning with a microfluidic device and subsequent dip-coating, containing a hydrogel core of bacterial cellulose (BC) and a conductive polymer shell layer of poly(3,4-ethylenedioxythiophene) (PEDOT). The hybrid microfibers were featured with a well-controlled microscopic morphology, exhibiting enhanced mechanic properties. A model drug, diclofenac sodium, can be loaded in the core layer of the microfibers in situ during the process of synthesis. Our experiments suggested that the releasing behaviors of the drug molecules from the microfibers were enhanced by external electrical stimulation. Interestingly, we demonstrated an excellent biocompatibility and electroactivity of the hybrid microfibers for PC12 cell culture, thus promising a flexible template for the reconstruction of electrically-responsive tissues mimicking muscle fibers or nerve networks. Fiber-shaped biomaterials are useful in creating various functional objects from one dimensional to three-dimensional. The fabrication of microfibers with integrated physicochemical properties and bio-performance has drawn an increasing attention on researchers from chemical to biomedical. This study combined biocompatible bacterial cellulose with electroconductive poly(3,4-ethylenedioxythiophene) and further reduced them to a highly electroactive BC/PEDOT core-shell microfiber electrode for electrochemical actuator design. The result showed that the microfibers were well fabricated and the release of drugs from the microfibers was enhanced and could be controlled under electrical stimulation externally. Considering the excellent biocompatibility and electroactive toward PC12 cells, these

  4. Efficient Integration of Pipelined IP Blocks into Automatically Compiled Datapaths

    Directory of Open Access Journals (Sweden)

    Andreas Koch

    2006-12-01

    Full Text Available Compilers for reconfigurable computers aim to generate problem-specific optimized datapaths for kernels extracted from an input language. In many cases, however, judicious use of preexisting manually optimized IP blocks within these datapaths could improve the compute performance even further. The integration of IP blocks into the compiled datapaths poses a different set of problems than stitching together IPs to form a system-on-chip; though, instead of the loose coupling using standard busses employed by SoCs, the one between datapath and IP block must be much tighter. To this end, we propose a concise language that can be efficiently synthesized using a template-based approach for automatically generating lightweight data and control interfaces at the datapath level.

  5. Efficient Integration of Pipelined IP Blocks into Automatically Compiled Datapaths

    Directory of Open Access Journals (Sweden)

    Koch Andreas

    2007-01-01

    Full Text Available Compilers for reconfigurable computers aim to generate problem-specific optimized datapaths for kernels extracted from an input language. In many cases, however, judicious use of preexisting manually optimized IP blocks within these datapaths could improve the compute performance even further. The integration of IP blocks into the compiled datapaths poses a different set of problems than stitching together IPs to form a system-on-chip; though, instead of the loose coupling using standard busses employed by SoCs, the one between datapath and IP block must be much tighter. To this end, we propose a concise language that can be efficiently synthesized using a template-based approach for automatically generating lightweight data and control interfaces at the datapath level.

  6. Shape-controlled synthesis of Au@Pd core-shell nanoparticles and their corresponding electrochemical properties

    KAUST Repository

    Song, Hyon Min

    2012-01-01

    The shape-controlled synthesis of Au@Pd core-shell nanoparticles (NPs) was successfully achieved through the emulsion phase generated during the phase transfer from organic to aqueous medium. Contrary to conventional epitaxial growth for obtaining core-shell structures, this method does not require high temperatures and does not have shape restrictions. © 2012 The Royal Society of Chemistry.

  7. Diseño de un sistema de control, automatización y monitoreo remoto para viviendas o negocios utilizando multimedia sobre ip

    OpenAIRE

    Molina, Maria Belen; Montesdeoca, Daniel J.; Leyton, Edgar

    2009-01-01

    El aumento constante en la demanda de mejorar la calidad de vida de las personas ha exigido un desarrollo tecnológico continuo. Se han diseñado diferentes artefactos que día a día pasan de ser lujos a necesidades. Dos de estos adelantos tecnológicos fueron las ideas del control automático y del control automático. Ambos se usan en diversos sistemas en la actualidad como son los acondicionadores de aire (control automático para establecer temperaturas en un ambiente, y ya la mayoría tienen...

  8. On using Mobile IP Protocols

    Directory of Open Access Journals (Sweden)

    Fayza A. Nada

    2006-01-01

    Full Text Available The recent advances in wireless communication technology and the unprecedented growth of the Internet have paved the way for wireless networking and IP mobility. Mobile Internet protocol has been designed within the IETF to support the mobility of users who wish to connect to the Internet and maintain communications as they move from place to place. This study describes and summarizes the current Internet draft for mobile IP (MIPv4 with its major components: agent discovery, registration and tunneling. In addition, we outline the available encapsulation techniques and route optimization procedure. In the end, we describe the design of the new protocol for transparent routing of IPv6 packets to mobile IPv6 nodes operating in the Internet.

  9. Security in VoIP

    Directory of Open Access Journals (Sweden)

    Floriana GEREA

    2012-04-01

    Full Text Available VoIP relies on packet switching, similar to the way that e-mails are sent over the Internet. The technology breaks down a voice call into bite-size information packets. Instead of keeping the switch open all the time, the information is sent and received as needed, allowing excess line capacity to be used to carry other data. When the voice data arrives at its destination, it's reassembled into a voice call. As voice over IP services grow in popularity, the potential for viruses, worms and other security threats aimed at the technology also will grow. The current paper's purpose is presenting several security solutions and applying them to integrated systems at an economical and social level.

  10. Internetworking with TCP/IP

    CERN Document Server

    Comer, Douglas E

    2014-01-01

    An internationally best-selling, conceptual introduction to the TCP/IP protocols and Internetworking, this book interweaves a clear discussion of fundamentals and scientific principles with details and examples drawn from the latest technologies. Leading author Douglas Comer covers layering and packet formats for all the Internet protocols, includingTCP, IPv4, IPv6, DHCP, and DNS. In addition, the text explains new trends in Internet systems, including packet classification, Software Defined Networking (SDN), and mesh protocols used in The Internet of Things. The text is appropriate for individuals interested in learning more about TCP/IP protocols, Internet architecture, and current networking technologies, as well as engineers who build network systems. It is suitable for junior to graduate-level courses in Computer Networks, Data Networks, Network Protocols, and Internetworking.

  11. Tacticity control in the synthesis of poly(lactic acid) polymer stars with dipentaerythritol cores.

    Science.gov (United States)

    Shaver, Michael P; Cameron, Donald J A

    2010-12-13

    The synthesis of a family of polymer stars with arms of varied tacticities is discussed. The effect of polymer tacticity on the physical properties of these polymer stars is presented. Dipentaerythritol cores support six poly(lactic acid) (PLA) arms. Lewis acidic tin and aluminum catalysts control the polymerization to afford polymer stars of variable tacticity. The analysis of these polymers by NMR spectroscopy, thermogravimetric analysis, powder X-ray diffraction, and differential scanning calorimetry reveals the effects of tacticity control on the physical properties of the polymer stars. Preliminary decomposition studies suggest that the biodegradation profile of a polymer star may also be tuned by stereochemical control. This is the first systematic altering of tacticity in PLA polymer stars, showing that polymer tacticity can have a great impact on star properties.

  12. [Induced pluripotent stem (iPS) cell - issues for clinical application - ].

    Science.gov (United States)

    Aoi, Takashi

    2013-01-01

    Induced pluripotent stem (iPS) cells are generated from somatic cells by introducing small sets of transcription factors. iPS cells demonstrate pluripotency and the ability to self-renew. In addition, iPS cells can be generated from donor individuals with particular characteristics. Based on these features, iPS cells are expected to be applicable in drug discovery, the study of disease mechanisms and cell therapy. From a technical point of view, "diversity" is the key word. At present, iPS cells can be derived using various techniques, resulting in diversity in the quality of iPS cells generated. Therefore, optimization of the derivation technology is one of the most important issues. Another "diversity" is in the propensities amongst iPS cell lines derived using similar techniques. Thus, strategies for selecting good quality lines remain to be established. Considering such technical hurdles, establishment of an iPS cell bank consisting of high quality and versatile iPS lines is a promising idea because of the merits of cost and quality control. Now, we are exploring relevant parameters for the quality control of banked cells. The challenges facing clinical application of iPS cells are new but not unprecedented. To realize clinical applications of iPS cells, we need to make these challenges clear and overcome them through partnership not only with industry, governments and universities, but also patients and society at large.

  13. IP Rights and Technological Platforms

    OpenAIRE

    Robert P. Merges

    2008-01-01

    This paper is about intellectual property rights (IPRs) and platform technologies. After a brief introduction explaining some basics of networks, standards and platforms, I turn to three policy issues. The first is the role of IP in what might be termed platform policies, the decisions by courts and regulators concerning whether and how to promote multi-party access to important digital platforms such as media player hardware, cell phones, PCs, and the like. I argue that for the most part the...

  14. Dispersion-controlled hollow core fiber for phase matched harmonic generation.

    Science.gov (United States)

    Christov, I; Kapteyn, H; Murnane, M

    1998-11-09

    We describe theoretically the performance of a new design for quasi-phase matched harmonic generation in a gas medium. A hollow core fiber in which thick glass plates are periodically introduced allows good phase control of the fundamental light. The generated x-rays are transmitted throught small holes in the plates. An increase of the harmonic yield of up to three orders of magnitude is predicted as a result of the structure. This esign can be considered as a phase-locked travelling-wave x-ray laser.

  15. Nonlinear control for core power of pressurized water nuclear reactors using constant axial offset strategy

    Directory of Open Access Journals (Sweden)

    Gholam Reza Ansarifar

    2015-12-01

    Full Text Available One of the most important operations in nuclear power plants is load following, in which an imbalance of axial power distribution induces xenon oscillations. These oscillations must be maintained within acceptable limits otherwise the nuclear power plant could become unstable. Therefore, bounded xenon oscillation is considered to be a constraint for the load following operation. In this paper, the design of a sliding mode control (SMC, which is a robust nonlinear controller, is presented. SMC is a means to control pressurized water nuclear reactor (PWR power for the load following operation problem in a way that ensures xenon oscillations are kept bounded within acceptable limits. The proposed controller uses constant axial offset (AO strategy to ensure xenon oscillations remain bounded. The constant AO is a robust state constraint for the load following problem. The reactor core is simulated based on the two-point nuclear reactor model with a three delayed neutron groups. The stability analysis is given by means of the Lyapunov approach, thus the control system is guaranteed to be stable within a large range. The employed method is easy to implement in practical applications and moreover, the SMC exhibits the desired dynamic properties during the entire output-tracking process independent of perturbations. Simulation results are presented to demonstrate the effectiveness of the proposed controller in terms of performance, robustness, and stability. Results show that the proposed controller for the load following operation is so effective that the xenon oscillations are kept bounded in the given region.

  16. Nonlinear control for core power of pressurized water nuclear reactors using constant axial offset strategy

    Energy Technology Data Exchange (ETDEWEB)

    Ansarifar, Gholam Reza; Saadatzi, Saeed [Dept. of Nuclear Engineering, Faculty of Advanced Sciences and Technology, University of Isfahan, Isfahan (Iran, Islamic Republic of)

    2015-12-15

    One of the most important operations in nuclear power plants is load following, in which an imbalance of axial power distribution induces xenon oscillations. These oscillations must be maintained within acceptable limits otherwise the nuclear power plant could become unstable. Therefore, bounded xenon oscillation is considered to be a constraint for the load following operation. In this paper, the design of a sliding mode control (SMC), which is a robust nonlinear controller, is presented. SMC is a means to control pressurized water nuclear reactor (PWR) power for the load following operation problem in a way that ensures xenon oscillations are kept bounded within acceptable limits. The proposed controller uses constant axial offset (AO) strategy to ensure xenon oscillations remain bounded. The constant AO is a robust state constraint for the load following problem. The reactor core is simulated based on the two-point nuclear reactor model with a three delayed neutron groups. The stability analysis is given by means of the Lyapunov approach, thus the control system is guaranteed to be stable within a large range. The employed method is easy to implement in practical applications and moreover, the SMC exhibits the desired dynamic properties during the entire output-tracking process independent of perturbations. Simulation results are presented to demonstrate the effectiveness of the proposed controller in terms of performance, robustness, and stability. Results show that the proposed controller for the load following operation is so effective that the xenon oscillations are kept bounded in the given region.

  17. Principle analysis of IP wavelength router

    Institute of Scientific and Technical Information of China (English)

    王勇; 殷洪玺; 徐安士; 吴德明

    2001-01-01

    Combining IP with WDM is an attractive direction for research. WDM will play an important role in IP network in future. Now, an urgent problem is how to introduce wavelength routing in an IP network. We solve this problem by designing IP wavelength router, implementing DPDP (default path and dedicated path) method. We prove the reasonableness and feasibility of this design by a principle experiment. A lot of problems related to this design are also discussed.

  18. The method to control the submarine horseshoe vortex by breaking the vortex core

    Institute of Scientific and Technical Information of China (English)

    LIU Zhi-hua; XIONG Ying; TU Cheng-xu

    2014-01-01

    The quality of the inflow across the propeller is closely related with the hydrodynamic performance and the noise characteristics of the propeller. For a submarine, with a horseshoe vortex generated at the junction of the main body and the appendages, the submarine wake is dominated by a kind of highly non-uniform flow field, which has an adverse effect on the performance of the submarine propeller. In order to control the horseshoe vortex and improve the quality of the submarine wake, the flow field around a submarine model is simulated by the detached eddies simulation (DES) method, and the vortex configuration is displayed using the second invariant of the velocity derivative tensor. The state and the transition process of the horseshoe vortex are analyzed, then a modified method to break the vortex core by a vortex baffle is proposed. The flow numerical simulation is carried out to study the effect of this method. Numerical simulations show that, with the breakdown of the vortex core, many unstable vortices are shed and the energy of the horseshoe vortex is dissipated quickly, and the uniformity of the submarine wake is improved. The submarine wake test in a wind tunnel has verified the effect of the method to control the horseshoe vortex. The vortex baffle can improve the wake uniformity in cases of high Reynolds numbers as well, and it does not have adverse effects on the maneuverability and the speed ability of the submarine.

  19. Effects of proprioceptive training program on core stability and center of gravity control in sprinters.

    Science.gov (United States)

    Romero-Franco, Natalia; Martínez-López, Emilio; Lomas-Vega, Rafael; Hita-Contreras, Fidel; Martínez-Amat, Antonio

    2012-08-01

    The purpose of this study was to determinate the effect of a 6-week specific-sprinter proprioceptive training program on core stability and gravity center control in sprinters. Thirty-three athletes (age = 21.82 ± 4.84 years, height = 1.76 ± 0.07 m, weight = 67.82 ± 08.04 kg, body mass index = 21.89 ± 2.37 kg · m(-2)) from sprint disciplines were divided into a control (n = 17) and experimental (n = 16) groups. A 30-minute proprioceptive training program was included in the experimental group training sessions, and it was performed for 6 weeks, 3 times each week. This program included 5 exercises with the BOSU and Swiss ball as unstable training tools that were designed to reproduce different moments of the technique of a sprint race. Stability with eyes open (EO) and eyes closed, postural stability, and gravity center control were assessed before and after the training program. Analyses of covariance (α = 0.05) revealed significant differences in stability in the medial-lateral plane with EO, gravity center control in the right direction and gravity center control in the back direction after the exercise intervention in the experimental athletes. Nevertheless, no other significant differences were demonstrated. A sprinter-specific proprioceptive training program provided postural stability with EO and gravity center control measures improvements, although it is not clear if the effect of training would transfer to the general population.

  20. Light-Harvesting Nanoparticle Core-Shell Clusters with Controllable Optical Output.

    Science.gov (United States)

    Sun, Dazhi; Tian, Ye; Zhang, Yugang; Xu, Zhihua; Sfeir, Matthew Y; Cotlet, Mircea; Gang, Oleg

    2015-06-23

    We used DNA self-assembly methods to fabricate a series of core-shell gold nanoparticle-DNA-colloidal quantum dot (AuNP-DNA-Qdot) nanoclusters with satellite-like architecture to modulate optical (photoluminescence) response. By varying the intercomponent distance through the DNA linker length designs, we demonstrate precise tuning of the plasmon-exciton interaction and the optical behavior of the nanoclusters from regimes characterized by photoluminescence quenching to photoluminescence enhancement. The combination of detailed X-ray scattering probing with photoluminescence intensity and lifetime studies revealed the relation between the cluster structure and its optical output. Compared to conventional light-harvesting systems like conjugated polymers and multichromophoric dendrimers, the proposed nanoclusters bring enhanced flexibility in controlling the optical behavior toward a desired application, and they can be regarded as controllable optical switches via the optically pumped color.

  1. Control of Microbial Growth in Alginate/Polydopamine Core/Shell Microbeads.

    Science.gov (United States)

    Kim, Beom Jin; Park, Taegyun; Park, So-Young; Han, Sang Woo; Lee, Hee-Seung; Kim, Yang-Gyun; Choi, Insung S

    2015-10-01

    Microbial microencapsulation not only protects microorganisms from harmful environments by physically isolating them from the outside media but also has the potential to tailor the release profile of the encapsulated cells. However, the microbial release has not yet been controlled tightly, leading to undesired detrimental exposure of microorganisms to the outside. In this work, we suggest a simple method for controlling the cell release by suppressing the microbial growth in the microbeads. Alginate microbeads, encapsulating yeast cells, were coated with ultrathin but robust polydopamine shells, and the resulting core/shell structures effectively reduced the growth rate, while maintaining the cell viability. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. On the Design of Energy Efficient Optical Networks with Software Defined Networking Control Across Core and Access Networks

    DEFF Research Database (Denmark)

    Wang, Jiayuan; Yan, Ying; Dittmann, Lars

    2013-01-01

    This paper presents a Software Defined Networking (SDN) control plane based on an overlay GMPLS control model. The SDN control platform manages optical core networks (WDM/DWDM networks) and the associated access networks (GPON networks), which makes it possible to gather global information...

  3. On the Design of Energy Efficient Optical Networks with Software Defined Networking Control Across Core and Access Networks

    DEFF Research Database (Denmark)

    Wang, Jiayuan; Yan, Ying; Dittmann, Lars

    2013-01-01

    This paper presents a Software Defined Networking (SDN) control plane based on an overlay GMPLS control model. The SDN control platform manages optical core networks (WDM/DWDM networks) and the associated access networks (GPON networks), which makes it possible to gather global information...

  4. Estudio de un kit de diseño mixto con Softcore Microblaze e IP's, para el control ESP, ASR y ABS

    OpenAIRE

    Sanz Moreno, Danilo; Aragonés Ortiz, Raúl

    2013-01-01

    Este proyecto consiste en el estudio de una placa de prototipado mixta analógico-digital formada principalmente por un PSoC, una FPGA y memoria flash para determinar sus capacidades en sistemas de control ESP, ASR y ABS. El estudio se basa en concluir la lógica que se puede añadir al dispositivo para enfocarlo a unas aplicaciones que, a pesar de ser muy comunes en coches, está poco desarrollado en motocicletas y ciclomotores. Es por ello surge el interés de diseñar un sistema del más bajo cos...

  5. Secure access control protocol for multi-source IP multicast%适用于多源IP组播的安全访问控制协议

    Institute of Scientific and Technical Information of China (English)

    王娜; 陈越; 汪斌强

    2006-01-01

    目前针对IP组播的安全访问控制问题的解决方案只是实现了对组播接收者的访问控制.为此,提出了一个广泛地适用于多源IP组播的安全访问控制协议(Multi-source Multicast Access Control,MMAC).协议通过引入专门的管理主机和管理频道实现了对组播参与者(发方和收方)及不可信路由器的安全访问控制.最后对MMAC协议的有效性和安全性进行了分析.

  6. Application of Socket (TCP/IP) in LED Lighting Control System Based on Android%基于Android的Socket(TCP/IP)在LED灯光控制系统中的应用

    Institute of Scientific and Technical Information of China (English)

    孙剑; 董超; 夏继媛; 李欣

    2012-01-01

    Based on TCP/IP communication protocols for data transmission, and through Zigbee wireless communication and ad hoc network, an android platform of client application is designed by adopting a Socket communication approach. The platform realized communication between wifi network and server through wireless communication, worked out a new approach to the remote control of the light in the Zigbee network by the terminal in android system, through which an intelligent control program for LED lamp is offered.%采用Socket的通信方法,根据TCP/IP通信协议进行数据传输,基于Android操作系统平台,通过Zigbee无线通信与自组网技术,设计了以Android操作系统为平台的客户端应用程序,实现了通过无线wifi网络与Windows系统的电脑服务器之间进行通信,解决了如何利用基于Android系统的手持终端对Zigbee无线网络中的LED灯光进行远程调控的问题,提出并实现了一种新的LED灯的智能控制方案.

  7. TCP/IP Network Administration

    CERN Document Server

    Hunt, Craig

    2002-01-01

    This complete guide to setting up and running a TCP/IP network is essential for network administrators, and invaluable for users of home systems that access the Internet. The book starts with the fundamentals -- what protocols do and how they work, how addresses and routing are used to move data through the network, how to set up your network connection -- and then covers, in detail, everything you need to know to exchange information via the Internet. Included are discussions on advanced routing protocols (RIPv2, OSPF, and BGP) and the gated software package that implements them, a tutorial

  8. 基于TCP/IP协议的家电远程控制系统设计%Design of Remote Control System in Household Appliances Based on TCP/IP Protocol

    Institute of Scientific and Technical Information of China (English)

    李开国; 康志亮; 丁武伟; 沈茂

    2011-01-01

    A new remote control system based on STC89C58RD+ and ENC28J60 is designed. The system applies the simplified TCP/IP protocol to communicate IPv4 network with microcontroller, and the microcontroller can control multiple home appliances simultaneously by using infrared communication. The website can accept a lot of requests from multiple users. The network programs process the communication between the network and the corresponding microcontroller with aim of providing a remote control scheme, among which the multiuser can control multiple home appliances successfully. Experiments are carried out, and the results show that the rice cooker can be controlled remotely through internet.%利用STC89 C58 RD+单片机与ENC28J60网卡芯片设计了一种家电远程控制系统.该系统采用精简的TCP/IP协议实现单片机与IPv4网络通信,单片机用红外通信的方法来同时控制多个家电.网站接收多个用户请求,网络程序处理与对应单片机之间的通信,从而提供一种多用户远程控制多个家电的方案.对电饭煲进行测试,结果显示该方案能够通过互联网远程控制电饭煲.

  9. Review on Application of Control Algorithms to Power Regulations of Reactor Cores

    OpenAIRE

    2016-01-01

    This research is to solve the stability analysis issue of nonlinear pressurized water reactor cores. On the basis of modeling a nonlinear pressurized water reactor core using the lumped parameter method, its linearized model is achieved via the small perturbation linearization way. Linearized models of the nonlinear core at six power levels are selected as local models of this core. The T-S fuzzy idea for the core is exploited to construct the T-S fuzzy model of the nonlinear core based on th...

  10. Control of vertebrate core planar cell polarity protein localization and dynamics by Prickle 2.

    Science.gov (United States)

    Butler, Mitchell T; Wallingford, John B

    2015-10-01

    Planar cell polarity (PCP) is a ubiquitous property of animal tissues and is essential for morphogenesis and homeostasis. In most cases, this fundamental property is governed by a deeply conserved set of 'core PCP' proteins, which includes the transmembrane proteins Van Gogh-like (Vangl) and Frizzled (Fzd), as well as the cytoplasmic effectors Prickle (Pk) and Dishevelled (Dvl). Asymmetric localization of these proteins is thought to be central to their function, and understanding the dynamics of these proteins is an important challenge in developmental biology. Among the processes that are organized by the core PCP proteins is the directional beating of cilia, such as those in the vertebrate node, airway and brain. Here, we exploit the live imaging capabilities of Xenopus to chart the progressive asymmetric localization of fluorescent reporters of Dvl1, Pk2 and Vangl1 in a planar polarized ciliated epithelium. Using this system, we also characterize the influence of Pk2 on the asymmetric dynamics of Vangl1 at the cell cortex, and we define regions of Pk2 that control its own localization and those impacting Vangl1. Finally, our data reveal a striking uncoupling of Vangl1 and Dvl1 asymmetry. This study advances our understanding of conserved PCP protein functions and also establishes a rapid, tractable platform to facilitate future in vivo studies of vertebrate PCP protein dynamics.

  11. Faceting control in core-shell GaN micropillars using selective epitaxy

    Directory of Open Access Journals (Sweden)

    Sergiy Krylyuk

    2014-10-01

    Full Text Available We report on the fabrication of large-area, vertically aligned GaN epitaxial core-shell micropillar arrays. The two-step process consists of inductively coupled plasma (ICP etching of lithographically patterned GaN-on-Si substrate to produce an array of micropillars followed by selective growth of GaN shells over these pillars using Hydride Vapor Phase Epitaxy (HVPE. The most significant aspect of the study is the demonstration of the sidewall facet control in the shells, ranging from {1 1 ̄ 01} semi-polar to {1 1 ̄ 00} non-polar planes, by employing a post-ICP chemical etch and by tuning the HVPE growth temperature. Room-temperature photoluminescence, cathodoluminescence, and Raman scattering measurements reveal substantial reduction of parasitic yellow luminescence as well as strain-relaxation in the core-shell structures. In addition, X-ray diffraction indicates improved crystal quality after the shell formation. This study demonstrates the feasibility of selective epitaxy on micro-/nano- engineered templates for realizing high-quality GaN-on-Si devices.

  12. Fabrication of monodispersive nanoscale alginate-chitosan core-shell particulate systems for controlled release studies

    Science.gov (United States)

    Körpe, Didem Aksoy; Malekghasemi, Soheil; Aydın, Uğur; Duman, Memed

    2014-12-01

    Biopolymers such as chitosan and alginate are widely used for controlled drug delivery systems. The present work aimed to develop a new protocol for preparation of monodisperse alginate-coated chitosan nanoparticles at nanoscale. Modifications of preparation protocol contain changing the pH of polymer solutions and adding extra centrifugation steps into the procedure. While chitosan nanoparticles were synthesized by ionic gelation method, they were coated with alginate by electrostatic interaction. The size, morphology, charge, and structural characterization of prepared core-shell nanoparticulated system were performed by AFM, Zeta sizer, and FTIR. BSA and DOX were loaded as test biomolecules to core and shell part of the nanoparticle, respectively. Release profiles of BSA and DOX were determined by spectrophotometry. The sizes of both chitosan and alginate-coated chitosan nanoparticles which were prepared by modified protocol were measured to be 50 ± 10 and 60 ± 3 nm, respectively. After loading BSA and DOX, the average size of the particles increased to 80 ± 7 nm. Moreover, while the zeta potential of chitosan nanoparticles was positive value, the value was inverted to negative after alginate coating. Release profile measurements of BSA and DOX were determined during 57 and 2 days, respectively. Our results demonstrated that monodisperse alginate-coated nanoparticles were synthesized and loaded successfully using our modified protocol.

  13. Encapsulation and controlled release from core-shell nanoparticles fabricated by plasma polymerization

    Science.gov (United States)

    Shahravan, Anaram; Matsoukas, Themis

    2012-01-01

    Core-shell nanostructures have been synthesized by plasma deposition in radio-frequency plasma reactor. Silica and KCl nanoparticles were encapsulated by deposition of isopropanol-based films of amorphous hydrogenated carbon. Through control of the deposition time, under constant deposition rate of 1 nm/min, particles are encapsulated in a layer of plasma polymer with thickness between 15 and 100 nm. Films are robust, chemically inert, thermally stable up to 250°C. The permeability of the shells is determined by depositing films of various thickness onto KCl nanoparticles and monitoring the dissolution of the core in aqueous solution. The dissolution profile is characterized by an initial rapid release, followed by a slow release that lasts up to 30 days for the thickest films. The profile is analyzed by Fickian diffusion through a spherical matrix. We find that this model captures very accurately the entire release profile except for the first 12 hours during which, the dissolution rate is higher than that predicted by the model. The overall diffusion coefficient for the dissolution of KCl is 3 × 10-21 m2/s.

  14. Controllable parabolic lensed liquid-core optical fiber by using electrostatic force.

    Science.gov (United States)

    Tang, Chun Yin; Zhang, Xuming; Chai, Yang; Hui, Long; Tao, Lili; Tsang, Yuen H

    2014-08-25

    For typical optical fiber system, an external lens accessory set is required to adjust the optical path of output light, which however is limited by the fixed parameter of the lens accessory setup. Considering spherical aberration in the imaging process and its small focusable spot size, a complicated lens combination is required to compensate the aberration. This paper has demonstrated a unique method to fabricate liquid-core lensed fibers by filling water and NOA61 respectively into hollow Teflon AF fibers and silicate fiber, the radius of curvature of the liquid lens can be controlled by adjusting the applied voltage on the core liquid and even parabolic shape lens can be produced with enough applied voltage. The experiment has successfully demonstrated a variation of focal length from 0.628 mm to 0.111 mm responding to the change of applied voltage from 0V to 3.2KV (L = 2mm) for the Teflon AF fiber, as well as a variation of focal length from 0.274 mm to 0.08 mm responding to the change of applied voltage from 0V to 3KV (L = 2mm) for the silicate fiber. Further simulation shows that the focused spot size can be reduced to 2 µm by adjusting the refractive index and fiber geometry. Solid state parabolic lensed fiber can be produced after NOA61 is solidified by the UV curing.

  15. IP over optical multicasting for large-scale video delivery

    Science.gov (United States)

    Jin, Yaohui; Hu, Weisheng; Sun, Weiqiang; Guo, Wei

    2007-11-01

    In the IPTV systems, multicasting will play a crucial role in the delivery of high-quality video services, which can significantly improve bandwidth efficiency. However, the scalability and the signal quality of current IPTV can barely compete with the existing broadcast digital TV systems since it is difficult to implement large-scale multicasting with end-to-end guaranteed quality of service (QoS) in packet-switched IP network. China 3TNet project aimed to build a high performance broadband trial network to support large-scale concurrent streaming media and interactive multimedia services. The innovative idea of 3TNet is that an automatic switched optical networks (ASON) with the capability of dynamic point-to-multipoint (P2MP) connections replaces the conventional IP multicasting network in the transport core, while the edge remains an IP multicasting network. In this paper, we will introduce the network architecture and discuss challenges in such IP over Optical multicasting for video delivery.

  16. Enabling IP Header Compression in COTS Routers via Frame Relay on a Simplex Link

    Science.gov (United States)

    Nguyen, Sam P.; Pang, Jackson; Clare, Loren P.; Cheng, Michael K.

    2010-01-01

    independently as a simplex link. Without negotiation, the COTS routers are prevented from entering into the IP header compression mode, and no IP header compression would be performed. An algorithm is proposed to enable IP header compression in COTS routers on a simplex link with no negotiation or with a one-way messaging. In doing so, COTS routers can enter IP header compression mode without the need to handshake through a bidirectional link as required by FRF.20. This technique would spoof the routers locally and thereby allow the routers to enter into IP header compression mode without having the negotiations between routers actually occur. The spoofing function is conducted by a frame relay adapter (also COTS) with the capability to generate control messages according to the FRF.20 descriptions. Therefore, negotiation is actually performed between the FRF.20 adapter and the connecting COTS router locally and never occurs over the space link. Through understanding of the handshaking protocol described by FRF.20, the necessary FRF.20 negotiations messages can be generated to control the connecting router, not only to turn on IP header compression but also to adjust the compression parameters. The FRF.20 negotiation (or control) message is composed in the FRF.20 adapter by interpreting the incoming router request message. Many of the fields are simply transcribed from request to response while the control field indicating response and type are modified.

  17. Assessing the Effect of Fuel Burnup on Control Rod Worth for HEU and LEU Cores of Gharr-1

    Directory of Open Access Journals (Sweden)

    E.K. Boafo

    2013-02-01

    Full Text Available An important parameter in the design and analysis of a nuclear reactor is the reactivity worth of the control rod which is a measure of the efficiency of the control rod to absorb excess reactivity. During reactor operation, the control rod worth is affected by factors such as the fuel burnup, Xenon concentration, Samarium concentration and the position of the control rod in the core. This study investigates the effect of fuel burnup on the control rod worth by comparing results of a fresh and an irradiated core of Ghana's Miniature Neutron Source Reactor for both HEU and LEU cores. In this study, two codes have been utilized namely BURNPRO for fuel burnup calculation and MCNP5 which uses densities of actinides of the irradiated fuel obtained from BURNPRO. Results showed a decrease of the control rod worth with burnup for the LEU while rod worth increased with burnup for the HEU core. The average thermal flux in both inner and outer irradiation sites also decreased significantly with burnup for both cores.

  18. Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP-DNA adduct formation.

    Science.gov (United States)

    Lin, Dong-Xin; Thompson, Patricia A; Teitel, Candee; Chen, Jun-Shi; Kadlubar, Fred F

    2003-01-01

    The chemopreventive effect of tea against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adduct formation and its mechanism were studied. Rats were exposed to freshly prepared aqueous extracts of green tea (3% (w/v)) as the sole source of drinking water for 10 days prior to administration with a single dose of PhIP (10 mg/kg body weight) by oral gavage. PhIP-DNA adducts in the liver, colon, heart, and lung were measured using the 32P-postlabelling technique. Rats pre-treated with tea and given PhIP 20 h before sacrifice had significantly reduced levels of PhIP-DNA adducts as compared with controls given PhIP alone. The possible mechanism of protective effect of tea on PhIP-DNA adduct formation was then examined in vitro. It was found that an aqueous extract of green and black tea, mixtures of green and black tea polyphenols, as well as purified polyphenols could strongly inhibit the DNA binding of N-acetoxy-PhIP, a putative ultimate carcinogen of PhIP formed in vivo via metabolic activation. Among these, epigallocatechin gallate was exceptionally potent. HPLC analyses of these incubation mixtures containing N-acetoxy-PhIP and the tea polyphenols each revealed the production of the parent amine, PhIP, indicating the involvement of a redox mechanism. In view of the presence of relatively high levels of tea polyphenols in rat and human plasma after ingestion of tea, this study suggests that direct reduction of the ultimate carcinogen N-acetoxy-PhIP by tea polyphenols is likely to be involved in the mechanism of chemoprotection of tea against this carcinogen.

  19. Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP-DNA adduct formation

    Energy Technology Data Exchange (ETDEWEB)

    Lin Dongxin; Thompson, Patricia A.; Teitel, Candee; Chen Junshi; Kadlubar, Fred F

    2003-03-01

    The chemopreventive effect of tea against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adduct formation and its mechanism were studied. Rats were exposed to freshly prepared aqueous extracts of green tea (3% (w/v)) as the sole source of drinking water for 10 days prior to administration with a single dose of PhIP (10 mg/kg body weight) by oral gavage. PhIP-DNA adducts in the liver, colon, heart, and lung were measured using the {sup 32}P-postlabelling technique. Rats pre-treated with tea and given PhIP 20 h before sacrifice had significantly reduced levels of PhIP-DNA adducts as compared with controls given PhIP alone. The possible mechanism of protective effect of tea on PhIP-DNA adduct formation was then examined in vitro. It was found that an aqueous extract of green and black tea, mixtures of green and black tea polyphenols, as well as purified polyphenols could strongly inhibit the DNA binding of N-acetoxy-PhIP, a putative ultimate carcinogen of PhIP formed in vivo via metabolic activation. Among these, epigallocatechin gallate was exceptionally potent. HPLC analyses of these incubation mixtures containing N-acetoxy-PhIP and the tea polyphenols each revealed the production of the parent amine, PhIP, indicating the involvement of a redox mechanism. In view of the presence of relatively high levels of tea polyphenols in rat and human plasma after ingestion of tea, this study suggests that direct reduction of the ultimate carcinogen N-acetoxy-PhIP by tea polyphenols is likely to be involved in the mechanism of chemoprotection of tea against this carcinogen.

  20. Controlled stimulation-burst targeted release by smart decentered core-shell microcapsules in gravity and magnetic field.

    Science.gov (United States)

    Ge, Xue-Hui; Huang, Jin-Pei; Xu, Jian-Hong; Luo, Guang-Sheng

    2014-12-07

    By combining gravity and magnetic force, we have developed a versatile and facile microfluidic method for forming magnetic decentered core-shell microcapsules in which the directions of the oil core and the magnetic nanoparticles are either opposed or the same. When the temperature rises above the LCST of the PNIPAm, the shell shrinks rapidly and the core targets burst release towards the converse or the same direction as the magnet. By adjusting the direction of the magnet, the release direction of the active substance could be correspondingly accurately controlled.

  1. Design of a decoupled AP1000 reactor core control system using digital proportional–integral–derivative (PID) control based on a quasi-diagonal recurrent neural network (QDRNN)

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Xinyu, E-mail: xyuwei@mail.xjtu.edu.cn; Wang, Pengfei, E-mail: pengfeixiaoli@yahoo.cn; Zhao, Fuyu, E-mail: fuyuzhao_xj@163.com

    2016-08-01

    Highlights: • We establish a disperse dynamic model for AP1000 reactor core. • A digital PID control based on QDRNN is used to design a decoupling control system. • The decoupling performance is verified and discussed. • The decoupling control system is simulated under the load following operation. - Abstract: The control system of the AP1000 reactor core uses the mechanical shim (MSHIM) strategy, which includes a power control subsystem and an axial power distribution control subsystem. To address the strong coupling between the two subsystems, an interlock between the two subsystems is used, which can only alleviate but not eliminate the coupling. Therefore, sometimes the axial offset (AO) cannot be controlled tightly, and the flexibility of load-following operation is limited. Thus, the decoupling of the original AP1000 reactor core control system is the focus of this paper. First, a two-node disperse dynamic model is established for the AP1000 reactor core to use PID control. Then, a digital PID control system based on a quasi-diagonal recurrent neural network (QDRNN) is designed to decouple the original system. Finally, the decoupling of the control system is verified by the step signal and load-following condition. The results show that the designed control system can decouple the original system as expected and the AO can be controlled much more tightly. Moreover, the flexibility of the load following is increased.

  2. Reducing handover latency in future IP-based wireless networks: Fast Proxy Mobile IPv6

    NARCIS (Netherlands)

    Heijenk, Geert; Bargh, Mortaza S.; Laganier, Julien; Prasad, Anand R.

    2008-01-01

    Current IP-level mobility protocols have difficulties meeting the stringent handover delay requirements of future wireless networks. At the same time they do not give sufficient control to the network to control the handover process. This paper presents an extension to Proxy Mobile IP, which is the

  3. Optical trapping and control of nanoparticles inside evacuated hollow core photonic crystal fibers

    Energy Technology Data Exchange (ETDEWEB)

    Grass, David, E-mail: david.grass@univie.ac.at; Fesel, Julian; Hofer, Sebastian G.; Kiesel, Nikolai; Aspelmeyer, Markus, E-mail: markus.aspelmeyer@univie.ac.at [Vienna Center for Quantum Science and Technology (VCQ), Faculty of Physics, University of Vienna, A-1090 Vienna (Austria)

    2016-05-30

    We demonstrate an optical conveyor belt for levitated nanoparticles over several centimeters inside both air-filled and evacuated hollow-core photonic crystal fibers (HCPCF). Detection of the transmitted light field allows three-dimensional read-out of the particle center-of-mass motion. An additional laser enables axial radiation pressure based feedback cooling over the full fiber length. We show that the particle dynamics is a sensitive local probe for characterizing the optical intensity profile inside the fiber as well as the pressure distribution along the fiber axis. In contrast to some theoretical predictions, we find a linear pressure dependence inside the HCPCF, extending over three orders of magnitude from 0.2 mbar to 100 mbar. A targeted application is the controlled delivery of nanoparticles from ambient pressure into medium vacuum.

  4. Munc13 controls the location and efficiency of dense-core vesicle release in neurons.

    Science.gov (United States)

    van de Bospoort, Rhea; Farina, Margherita; Schmitz, Sabine K; de Jong, Arthur; de Wit, Heidi; Verhage, Matthijs; Toonen, Ruud F

    2012-12-10

    Neuronal dense-core vesicles (DCVs) contain diverse cargo crucial for brain development and function, but the mechanisms that control their release are largely unknown. We quantified activity-dependent DCV release in hippocampal neurons at single vesicle resolution. DCVs fused preferentially at synaptic terminals. DCVs also fused at extrasynaptic sites but only after prolonged stimulation. In munc13-1/2-null mutant neurons, synaptic DCV release was reduced but not abolished, and synaptic preference was lost. The remaining fusion required prolonged stimulation, similar to extrasynaptic fusion in wild-type neurons. Conversely, Munc13-1 overexpression (M13OE) promoted extrasynaptic DCV release, also without prolonged stimulation. Thus, Munc13-1/2 facilitate DCV fusion but, unlike for synaptic vesicles, are not essential for DCV release, and M13OE is sufficient to produce efficient DCV release extrasynaptically.

  5. Optical trapping and control of nanoparticles inside evacuated hollow core photonic crystal fibers

    CERN Document Server

    Grass, David; Hofer, Sebastian G; Kiesel, Nikolai; Aspelmeyer, Markus

    2016-01-01

    We demonstrate an optical conveyor belt for levitated nano-particles over several centimeters inside both air-filled and evacuated hollow-core photonic crystal fibers (HCPCF). Detection of the transmitted light field allows three-dimensional read-out of the particle center-of-mass motion. An additional laser enables axial radiation pressure based feedback cooling over the full fiber length. We show that the particle dynamics is a sensitive local probe for characterizing the optical intensity profile inside the fiber as well as the pressure distribution along the fiber axis. In contrast to previous indirect measurement methods we find a linear pressure dependence inside the HCPCF extending over three orders of magnitude from 0.2 mbar to 100 mbar. A targeted application is the controlled delivery of nano-particles from ambient pressure into medium vacuum.

  6. Lattice-strain control of the activity in dealloyed core-shell fuel cell catalysts.

    Science.gov (United States)

    Strasser, Peter; Koh, Shirlaine; Anniyev, Toyli; Greeley, Jeff; More, Karren; Yu, Chengfei; Liu, Zengcai; Kaya, Sarp; Nordlund, Dennis; Ogasawara, Hirohito; Toney, Michael F; Nilsson, Anders

    2010-06-01

    Electrocatalysis will play a key role in future energy conversion and storage technologies, such as water electrolysers, fuel cells and metal-air batteries. Molecular interactions between chemical reactants and the catalytic surface control the activity and efficiency, and hence need to be optimized; however, generalized experimental strategies to do so are scarce. Here we show how lattice strain can be used experimentally to tune the catalytic activity of dealloyed bimetallic nanoparticles for the oxygen-reduction reaction, a key barrier to the application of fuel cells and metal-air batteries. We demonstrate the core-shell structure of the catalyst and clarify the mechanistic origin of its activity. The platinum-rich shell exhibits compressive strain, which results in a shift of the electronic band structure of platinum and weakening chemisorption of oxygenated species. We combine synthesis, measurements and an understanding of strain from theory to generate a reactivity-strain relationship that provides guidelines for tuning electrocatalytic activity.

  7. The Importance of Sensory-Motor Control in Providing Core Stability Implications for Measurement and Training

    NARCIS (Netherlands)

    Borghuis, Jan; Hof, At L.; Lemmink, Koen A. P. M.

    2008-01-01

    Although the hip musculature is found to be very important in connecting the core to the lower extremities and in transferring forces from and to the core, it is proposed to leave the hip musculature out of consideration when talking about the concept of core stability. A low level of co-contraction

  8. Bidirectional lipid droplet velocities are controlled by differential binding strengths of HCV core DII protein.

    Science.gov (United States)

    Lyn, Rodney K; Hope, Graham; Sherratt, Allison R; McLauchlan, John; Pezacki, John Paul

    2013-01-01

    Host cell lipid droplets (LD) are essential in the hepatitis C virus (HCV) life cycle and are targeted by the viral capsid core protein. Core-coated LDs accumulate in the perinuclear region and facilitate viral particle assembly, but it is unclear how mobility of these LDs is directed by core. Herein we used two-photon fluorescence, differential interference contrast imaging, and coherent anti-Stokes Raman scattering microscopies, to reveal novel core-mediated changes to LD dynamics. Expression of core protein's lipid binding domain II (DII-core) induced slower LD speeds, but did not affect directionality of movement on microtubules. Modulating the LD binding strength of DII-core further impacted LD mobility, revealing the temporal effects of LD-bound DII-core. These results for DII-core coated LDs support a model for core-mediated LD localization that involves core slowing down the rate of movement of LDs until localization at the perinuclear region is accomplished where LD movement ceases. The guided localization of LDs by HCV core protein not only is essential to the viral life cycle but also poses an interesting target for the development of antiviral strategies against HCV.

  9. The Importance of Sensory-Motor Control in Providing Core Stability Implications for Measurement and Training

    NARCIS (Netherlands)

    Borghuis, Jan; Hof, At L.; Lemmink, Koen A. P. M.

    2008-01-01

    Although the hip musculature is found to be very important in connecting the core to the lower extremities and in transferring forces from and to the core, it is proposed to leave the hip musculature out of consideration when talking about the concept of core stability. A low level of co-contraction

  10. Bidirectional Lipid Droplet Velocities Are Controlled by Differential Binding Strengths of HCV Core DII Protein

    Science.gov (United States)

    Lyn, Rodney K.; Hope, Graham; Sherratt, Allison R.; McLauchlan, John; Pezacki, John Paul

    2013-01-01

    Host cell lipid droplets (LD) are essential in the hepatitis C virus (HCV) life cycle and are targeted by the viral capsid core protein. Core-coated LDs accumulate in the perinuclear region and facilitate viral particle assembly, but it is unclear how mobility of these LDs is directed by core. Herein we used two-photon fluorescence, differential interference contrast imaging, and coherent anti-Stokes Raman scattering microscopies, to reveal novel core-mediated changes to LD dynamics. Expression of core protein’s lipid binding domain II (DII-core) induced slower LD speeds, but did not affect directionality of movement on microtubules. Modulating the LD binding strength of DII-core further impacted LD mobility, revealing the temporal effects of LD-bound DII-core. These results for DII-core coated LDs support a model for core-mediated LD localization that involves core slowing down the rate of movement of LDs until localization at the perinuclear region is accomplished where LD movement ceases. The guided localization of LDs by HCV core protein not only is essential to the viral life cycle but also poses an interesting target for the development of antiviral strategies against HCV. PMID:24223760

  11. Vaccines and IP Rights: A Multifaceted Relationship.

    Science.gov (United States)

    Durell, Karen

    2016-01-01

    Just as there are many forms of vaccines and components to vaccines-particular compositions, delivery systems, components, and distribution networks-there are a variety of intellectual property (IP) protections applicable for vaccines. IP rights such as patent, copyright, trademarks, plant breeders' rights, and trade secrets may all be applicable to vaccines. Thus, discussion of IP rights and vaccines should not begin and end with the application of one IP right to a vaccine. The discussion should engage considerations of multiple IP rights applicable to a vaccine and how these can be utilized in an integrated manner in a strategy aimed at supporting the development and distribution of the vaccine. Such an approach to IP rights to vaccines allows for the integrated rights to be considered in light of the justifications for protecting vaccines with IP rights, as well as the issues relating to specific IP rights for vaccines, such as compulsory license regimes, available humanitarian purpose IP credits, etc. To view vaccines as the subject of multiple IP protections involves a refocusing, but the outcome can provide significant benefits for vaccine development and distribution.

  12. Applying a gaming approach to IP strategy.

    Science.gov (United States)

    Gasnier, Arnaud; Vandamme, Luc

    2010-02-01

    Adopting an appropriate IP strategy is an important but complex area, particularly in the pharmaceutical and biotechnology sectors, in which aspects such as regulatory submissions, high competitive activity, and public health and safety information requirements limit the amount of information that can be protected effectively through secrecy. As a result, and considering the existing time limits for patent protection, decisions on how to approach IP in these sectors must be made with knowledge of the options and consequences of IP positioning. Because of the specialized nature of IP, it is necessary to impart knowledge regarding the options and impact of IP to decision-makers, whether at the level of inventors, marketers or strategic business managers. This feature review provides some insight on IP strategy, with a focus on the use of a new 'gaming' approach for transferring the skills and understanding needed to make informed IP-related decisions; the game Patentopolis is discussed as an example of such an approach. Patentopolis involves interactive activities with IP-related business decisions, including the exploitation and enforcement of IP rights, and can be used to gain knowledge on the impact of adopting different IP strategies.

  13. The design of remote control system for fully automatic rice cooker based on TCP/IP protocol%基于TCP/IP协议的全自动电饭煲远程控制系统设计

    Institute of Scientific and Technical Information of China (English)

    康志亮; 李开国; 许丽佳

    2011-01-01

    提出了一种全自动电饭煲远程控制系统的设计方案.采用精简的TCP/IP协议实现STC89C58RD+单片机与因特网络通信,STC89C58RD+单片机通过红外通信的方法控制全自动电饭煲.网站接受用户请求,网络程序处理与电饭煲微控制器之间的通信,微控制器实现对电饭煲的全自动控制.另外,在电饭煲原有的基础上,设计了储米、取米、淘米、放米、加水等机械装置,以实现电饭煲机电一体化.系统测试结果显示,该系统操作方便,成本低,稳定性高且扩展性好.%The paper designed a remote control system for fully automatic rice cooker. In this system a simplified TCP/IP protocol is applied to communicate intemet network with STC89C58RD+, and then the rice cooker is controlled by infrared communication method. The Website can accept request from user, and then the network programs can process the communication between internet network and the microcontroller which controls the fully automatic rice cooker. Additionally, some mechanical installations for storing rice, taking dee, washing rice, placing rice and adding water, are designed to achieve mechanical-electrical integration.The proposed system is tested, and the experiment results show that the system has some advantages such as simple operation, low cost, high stability and good expansibility.

  14. Analysis of Handoff Mechanisms in Mobile IP

    Science.gov (United States)

    Jayaraj, Maria Nadine Simonel; Issac, Biju; Haldar, Manas Kumar

    2011-06-01

    One of the most important challenges in mobile Internet Protocol (IP) is to provide service for a mobile node to maintain its connectivity to network when it moves from one domain to another. IP is responsible for routing packets across network. The first major version of IP is the Internet Protocol version 4 (IPv4). It is one of the dominant protocols relevant to wireless network. Later a newer version of IP called the IPv6 was proposed. Mobile IPv6 is mainly introduced for the purpose of mobility. Mobility management enables network to locate roaming nodes in order to deliver packets and maintain connections with them when moving into new domains. Handoff occurs when a mobile node moves from one network to another. It is a key factor of mobility because a mobile node can trigger several handoffs during a session. This paper briefly explains on mobile IP and its handoff issues, along with the drawbacks of mobile IP.

  15. [iPS cells in dentistry].

    Science.gov (United States)

    Egusa, Hiroshi

    2012-01-01

    The discovery of the induced pluripotent stem (iPS) cell technology, which enables us to produce pluripotent stem cells by introducing a few genetic factors, commands considerable attention in the field of dentistry. These iPS cells may be of particular importance for developing innovative technologies to regenerate missing jaw bones and lost teeth, and there are expectations that several types of tissue stem cells and mucosal cells in the oral area can be used as an ideal iPS cell source. We previously reported that the gingiva, which is often resected during general dental treatments and treated as biomedical waste, is a promising source of iPS cells. In this review, the current trends in iPS cell research in dentistry are outlined, and future aspects of potential applications of the iPS cell technologies to dental treatments will be discussed.

  16. SISTEMI IPTV NA IP MULTIMEDIJSKEM PODSISTEMU

    OpenAIRE

    2013-01-01

    Diplomsko delo obravnava arhitekture sistemov IPTV na IP multimedijskem podsistemu ter pripadajoče storitve in funkcije IPTV na IP multimedijskem podsistemu. Predstavljene arhitekture prinašajo veliko novih funkcionalnosti, ki so podrobneje predstavljene po posameznih enotah. V nalogi je tudi podrobneje opisana arhitektura IP multimedijskega podsistema z ravninami in protokoli. Naloga se zaključuje s storitvami na takšnih arhitekturah.

  17. Optimal Filtering of Malicious IP Sources

    CERN Document Server

    Soldo, Fabio; Argyraki, Katerina

    2008-01-01

    How can we protect the network infrastructure from malicious traffic, such as scanning, malicious code propagation, and distributed denial-of-service (DDoS) attacks? One mechanism for blocking malicious traffic is filtering: access control lists (ACLs) can selectively block traffic based on fields of the IP header. Filters (ACLs) are already available in the routers today but are a scarce resource because they are stored in the expensive ternary content addressable memory (TCAM). In this paper, we develop, for the first time, a framework for studying filter selection as a resource allocation problem. Within this framework, we study five practical cases of source address/prefix filtering, which correspond to different attack scenarios and operator's policies. We show that filter selection optimization leads to novel variations of the multidimensional knapsack problem and we design optimal, yet computationally efficient, algorithms to solve them. We also evaluate our approach using data from Dshield.org and dem...

  18. TCP/IP Over SpaceWire

    Science.gov (United States)

    Mills, S.; Parkes, S.

    The SpaceWire standard defines a network designed for handling payload data and control information onboard a spacecraft. Among the goals of SpaceWire are re-usability and reliability. The use of network protocols on top of SpaceWire is expected to enhance the already rich re-usability and reliability characteristics of SpaceWire. The Space Systems Research Group at the University of Dundee have developed software to allow data to be sent over SpaceWire using standard network protocols such as TCP/IP, as part of a program of work looking at network protocols for SpaceWire. This paper describes network protocols and their relationship to SpaceWire, introduces software written to allow network protocols to be layered on to SpaceWire, describes the research behind the development of this software, and gives results of some tests and observations made using the software.

  19. Shape-controlled synthesis of Pt-Pd core-shell nanoparticles exhibiting polyhedral morphologies by modified polyol method

    Energy Technology Data Exchange (ETDEWEB)

    Long, Nguyen Viet, E-mail: nguyenviet_long@yahoo.com [Department of Materials Science and Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan); Posts and Telecommunications Institute of Technology, Nguyen Trai, Hanoi (Viet Nam); Asaka, Toru; Matsubara, Takashi [Department of Materials Science and Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan); Nogami, Masayuki, E-mail: nogami@nitech.ac.jp [Department of Materials Science and Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan)

    2011-04-15

    Pt-Pd core-shell nanoparticles were synthesized by a simple synthetic method. First, Pt nanoparticles were synthesized in a controlled manner via the reduction of chloroplantinic acid hexahydrate in ethylene glycol (EG) at 160 deg. C in the presence of silver nitrate and the stabilization of polyvinylpyrrolidon. AgNO{sub 3} used acts as a structure-modifying agent to the morphology of the Pt nanoparticles. These Pt nanoparticles function as the seeds for the successive reduction of sodium tetrachloropalladate (II) hydrate in EG under stirring for 15 min at 160 deg. C in order to synthesize Pt-Pd core-shell nanoparticles. To characterize the as-prepared Pt-Pd nanoparticles, transmission electron microscopy (TEM) and high-resolution TEM are used. The high-resolution elemental mappings were carried out using the combination of scanning TEM and X-ray energy-dispersive spectroscopy. The results also demonstrate the homogeneous nucleation and growth of the Pd metal shell on the definite Pt core. The synthesized Pt-Pd core-shell nanoparticles exhibit a sharp and polyhedral morphology. The epitaxial growth of the controlled Pd shells on the Pt cores via a polyol method was observed. It is suggested that Frank-van der Merwe and Stranski-Krastanov growth modes coexisted in the nucleation and growth of Pt-Pd core-shell nanoparticles.

  20. Universal Space IP Transparent Proxy Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Communications applications are strategically moving toward Internet Protocol-based architectures and technologies. Despite IP's huge potential, (e.g. cost...

  1. A Multi-core Heterogeneous Programmable Automation Controller System of Construction Machine

    Directory of Open Access Journals (Sweden)

    WANG Guoqing

    2013-07-01

    Full Text Available There are two main issues, high cost and interrupt response delay for current PACs (programmable automation controllers which are using high frequency single-chip microprocessors and commercial RTOS (real-time operating system working by switching the tasks and interrupts. To solve these problems, a new low-cost multi-core heterogeneous PAC structure was proposed. Based on the traditional front-end of interrupt service without interrupt switching delay and the division & deployment of multi real-time tasks. We implemented a new programming language Engineer C including its syntax, compiler and an integrated development environment, which can dynamically divide the multi tasks and deploy the division to single low-cost microcontroller, then built the hardware prototype, which consists of a digital signal board, an analog signal board and a motion control board, every board has its microcontroller and communicates each other by an enhanced SPI bus. Testing results show the hardware prototype and IDE can be provided as a low-cost PAC solution for construction machine.

  2. Fabrication, characterization, and theoretical analysis of controlled disorder in the core of optical fibers.

    Science.gov (United States)

    Puente, Norma P; Chaikina, Elena I; Herath, Sumudu; Yamilov, Alexey

    2011-02-20

    We present results of experimental and theoretical studies of polarization-resolved light transmission through optical fiber with disorder generated in its germanium-doped core via UV radiation transmitted through a diffuser. In samples longer than a certain characteristic length, the power transmitted with preserved polarization is observed to be distributed over all forward-propagating modes, as evidenced by the Rayleigh negative exponential distribution of the near-field intensity at the output surface of the fiber. Furthermore, the transmitted power becomes also equally distributed over both polarizations. To describe the optical properties of the fibers with the experimentally induced disorder, a theoretical model based on coupled-mode theory is developed. The obtained analytical expression for the correlation function describing spatial properties of the disorder shows that it is highly anisotropic. Our calculations demonstrate that this experimentally controllable anisotropy can lead to suppression of the radiative leakage of the propagating modes, so that intermode coupling becomes the dominant scattering process. The obtained theoretical expressions for the polarization-resolved transmission fit very well with the experimental data, and the information extracted from the fit shows that radiative leakage is indeed small. The reported technique provides an easy way to fabricate different configurations of controlled disorder in optical fibers suitable for such applications as random fiber lasers.

  3. QoS-guaranteed burst transmission for VoIP service over optical burst switching networks

    Science.gov (United States)

    Tachibana, Takuji; Kasahara, Shoji

    2007-08-01

    We propose a burst transmission method that guarantees the voice over Internet protocol (VoIP) service. The proposed method consists of three techniques: round-robin burst assembly with slotted scheduling, priority control with void filling, and hop-based preemption. Each technique is utilized so that the burst loss probability and the burst transmission delay satisfy VoIP quality of service (QoS). We evaluate by simulation the performance of the proposed method in NSFNET with 14 nodes. Numerical examples show that our proposed method is effective for guaranteeing the VoIP QoS while accommodating a large number of VoIP users.

  4. Parameter Design and Optimal Control of an Open Core Flywheel Energy Storage System

    Science.gov (United States)

    Pang, D.; Anand, D. K.; Kirk, J. A.

    1996-01-01

    In low earth orbit (LEO) satellite applications spacecraft power is provided by photovoltaic cells and batteries. To overcome battery shortcomings the University of Maryland, working in cooperation with NASA/GSFC and NASA/LeRC, has developed a magnetically suspended flywheel for energy storage applications. The system is referred to as an Open Core Composite Flywheel (OCCF) energy storage system. Successful application of flywheel energy storage requires integration of several technologies, viz. bearings, rotor design, motor/generator, power conditioning, and system control. In this paper we present a parameter design method which has been developed for analyzing the linear SISO model of the magnetic bearing controller for the OCCF. The objective of this continued research is to principally analyze the magnetic bearing system for nonlinear effects in order to increase the region of stability, as determined by high speed and large air gap control. This is achieved by four tasks: (1) physical modeling, design, prototyping, and testing of an improved magnetically suspended flywheel energy storage system, (2) identification of problems that limit performance and their corresponding solutions, (3) development of a design methodology for magnetic bearings, and (4) design of an optimal controller for future high speed applications. Both nonlinear SISO and MIMO models of the magnetic system were built to study limit cycle oscillations and power amplifier saturation phenomenon observed in experiments. The nonlinear models include the inductance of EM coils, the power amplifier saturation, and the physical limitation of the flywheel movement as discussed earlier. The control program EASY5 is used to study the nonlinear SISO and MIMO models. Our results have shown that the characteristics and frequency responses of the magnetic bearing system obtained from modeling are comparable to those obtained experimentally. Although magnetic saturation is shown in the bearings, there

  5. Bottom-up control of geomagnetic secular variation by the Earth's inner core.

    Science.gov (United States)

    Aubert, Julien; Finlay, Christopher C; Fournier, Alexandre

    2013-10-10

    Temporal changes in the Earth's magnetic field, known as geomagnetic secular variation, occur most prominently at low latitudes in the Atlantic hemisphere (that is, from -90 degrees east to 90 degrees east), whereas in the Pacific hemisphere there is comparatively little activity. This is a consequence of the geographical localization of intense, westward drifting, equatorial magnetic flux patches at the core surface. Despite successes in explaining the morphology of the geomagnetic field, numerical models of the geodynamo have so far failed to account systematically for this striking pattern of geomagnetic secular variation. Here we show that it can be reproduced provided that two mechanisms relying on the inner core are jointly considered. First, gravitational coupling aligns the inner core with the mantle, forcing the flow of liquid metal in the outer core into a giant, westward drifting, sheet-like gyre. The resulting shear concentrates azimuthal magnetic flux at low latitudes close to the core-mantle boundary, where it is expelled by core convection and subsequently transported westward. Second, differential inner-core growth, fastest below Indonesia, causes an asymmetric buoyancy release in the outer core which in turn distorts the gyre, forcing it to become eccentric, in agreement with recent core flow inversions. This bottom-up heterogeneous driving of core convection dominates top-down driving from mantle thermal heterogeneities, and localizes magnetic variations in a longitudinal sector centred beneath the Atlantic, where the eccentric gyre reaches the core surface. To match the observed pattern of geomagnetic secular variation, the solid material forming the inner core must now be in a state of differential growth rather than one of growth and melting induced by convective translation.

  6. Internet Connection of a Broadband Wireless IP Network Based on a Fast Mobile IP Algorithm with Link Layer Support

    Institute of Scientific and Technical Information of China (English)

    XIONGYan; MIAOFuyou; HUABei; WANGXingfu

    2003-01-01

    Commercialized wireless LANs (local area networks) are emerging one after another. Because a lot of useful information and resources are residing in the wired network, Internet, the strong requirement to access In-ternet for mobile hosts in wireless LANs is growing more and more. In this paper, we simply describe the topoi-ogy and feature of a broadband wireless Internet protocol network (BWIPN) in which data transmitted on wireless link is encapsulated within Internet protocol (IP) packets.To connect to Internet, there is an Internet connecting server (ICS) which is also a router within every BWIPN.A fast mobile IP hand-offalgorithm with link layer supportto reduce handoff overhead has been proposed to providemobility support for wireless terminals (WTs, i.e. note-book computers) roaming among BWIPNs without chang-ing their IP addresses. An indirect TCP (transfer control protocol) scheme is used to improve the performance ofwireless TCP. To match data transmission rate on the wire-less link with that on the wired link, an adaptive wireless congestion control algorithms are added at IP layers in the WT and the ICS. Both performance analysis and experi-mental result have shown that the fast mobile IP hand-off algorithm reduces the hand-off delay by about 10 times and TCP disconnection times is reduced greatly, compared with the three known mobile IP hand-off algorithms. By our work, users on WTs can explore Internet using Web browser, File Transfer Protocol, Telnet and Ping utilities while moving among different BWIPNs very well.

  7. Magnetoelastoelectric coupling in core-shell nanoparticles enabling directional and mode-selective magnetic control of THz beam propagation.

    Science.gov (United States)

    Dutta, Moumita; Natarajan, Kamaraju; Betal, Soutik; Prasankumar, Rohit P; Bhalla, Amar S; Guo, Ruyan

    2017-09-14

    Magnetoelastoelectric coupling in an engineered biphasic multiferroic nanocomposite enables a novel magnetic field direction-defined propagation control of terahertz (THz) waves. These core-shell nanoparticles are comprised of a ferromagnetic cobalt ferrite core and a ferroelectric barium titanate shell. An assembly of these nanoparticles, when operated in external magnetic fields, exhibits a controllable amplitude modulation when the magnetic field is applied antiparallel to the THz wave propagation direction; yet the same assembly displays an additional phase modulation when the magnetic field is applied along the propagation direction. While field-induced magnetostriction of the core leads to amplitude modulation, phase modulation is a result of stress-mediated piezoelectricity of the outer ferroelectric shell.

  8. An interplay between 2 signaling pathways: Melatonin-cAMP and IP{sub 3}–Ca{sup 2+} signaling pathways control intraerythrocytic development of the malaria parasite Plasmodium falciparum

    Energy Technology Data Exchange (ETDEWEB)

    Furuyama, Wakako [National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555 (Japan); Enomoto, Masahiro [Princess Margaret Cancer Centre, Department of Medical Biophysics, University of Toronto, M5G1L7 Toronto, Ontario (Canada); Mossaad, Ehab [National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555 (Japan); Kawai, Satoru [Laboratory of Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Tochigi 321-0293 (Japan); Mikoshiba, Katsuhiko [Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351-0198 (Japan); Kawazu, Shin-ichiro, E-mail: skawazu@obihiro.ac.jp [National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555 (Japan)

    2014-03-28

    Highlights: • A melatonin receptor antagonist blocked Ca{sup 2+} oscillation in P. falciparum and inhibited parasite growth. • P. falciparum development is controlled by Ca{sup 2+}- and cAMP-signaling pathways. • The cAMP-signaling pathway at ring form and late trophozoite stages governs parasite growth of P. falciparum. - Abstract: Plasmodium falciparum spends most of its asexual life cycle within human erythrocytes, where proliferation and maturation occur. Development into the mature forms of P. falciparum causes severe symptoms due to its distinctive sequestration capability. However, the physiological roles and the molecular mechanisms of signaling pathways that govern development are poorly understood. Our previous study showed that P. falciparum exhibits stage-specific spontaneous Calcium (Ca{sup 2+}) oscillations in ring and early trophozoites, and the latter was essential for parasite development. In this study, we show that luzindole (LZ), a selective melatonin receptor antagonist, inhibits parasite growth. Analyses of development and morphology of LZ-treated P. falciparum revealed that LZ severely disrupted intraerythrocytic maturation, resulting in parasite death. When LZ was added at ring stage, the parasite could not undergo further development, whereas LZ added at the trophozoite stage inhibited development from early into late schizonts. Live-cell Ca{sup 2+} imaging showed that LZ treatment completely abolished Ca{sup 2+} oscillation in the ring forms while having little effect on early trophozoites. Further, the melatonin-induced cAMP increase observed at ring and late trophozoite stage was attenuated by LZ treatment. These suggest that a complex interplay between IP{sub 3}–Ca{sup 2+} and cAMP signaling pathways is involved in intraerythrocytic development of P. falciparum.

  9. Finite Element Analysis of IPS –Empress II Ceramic Bridge Reinforced by Zirconia Bar

    Directory of Open Access Journals (Sweden)

    Allahyar Geramy

    2012-01-01

    Full Text Available Objective: The aim of this study was to determine the effect of trenched zirconia bar on the von Mises stress distribution of IPS –Empress II core ceramics.Material and Methods: The three-dimensional model including a three-unit bridge from the second premolar to the second molar was designed. The model was reinforced with zirconia bar (ZB, zirconia bar with vertical trench (VZB, and zirconia bar with horizontal trench (HZB (cross sections of these bars were circular. The model without zirconia bar was designed as the control. The bridges were loaded by 200 N and 500 N on the occlusal surface at the middle of the pontic component, and Von-Mises stresses were evaluated along a defined path.Result: In the connector area, VonMises stress in MPa were approximately identical in the specimens with ZB (at molar connector (MC: 4.75, and at premolar connector (PC: 6.40 and without ZB (MC: 5.50, PC: 6.68, and considerable differences were not recognized. Whereas, Von-Mises stress (MPa in the specimens with horizontal trenched Zirconia bar (HZB (MC: 3.91, PC: 2.44 and Vertical trenched Zirconia bar (VZB (MC: 2.53, PC: 2.56 was decreased considerably.Conclusion: Embeded trenched zirconia bar could reinforce IPS-Empress II at the connector area which is a main failure region in all ceramic fixed partial dentures.

  10. Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq

    NARCIS (Netherlands)

    Johannes, Frank; Wardenaar, Rene; Colomé Tatché, Maria; Mousson, Florence; de Graaf, Petra; Mokry, Michal; Guryev, Victor; Timmers, H. Th. Marc; Cuppen, Edwin; Jansen, Ritsert C.; Bateman, Alex

    2010-01-01

    Motivation: ChIP-chip and ChIP-seq technologies provide genomewide measurements of various types of chromatin marks at an unprecedented resolution. With ChIP samples collected from different tissue types and/ or individuals, we can now begin to characterize stochastic or systematic changes in epigen

  11. Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq

    NARCIS (Netherlands)

    Johannes, F.; Wardenaar, R.; Colome-Tatche, M.; Mousson, F.; de Graaf, P.; Mokry, M.; Guryev, V.; Timmers, H.T.; Cuppen, E.; Jansen, R.

    2010-01-01

    MOTIVATION: ChIP-chip and ChIP-seq technologies provide genome-wide measurements of various types of chromatin marks at an unprecedented resolution. With ChIP samples collected from different tissue types and/or individuals, we can now begin to characterize stochastic or systematic changes in epigen

  12. 75 FR 13235 - IP-Enabled Services

    Science.gov (United States)

    2010-03-19

    ... interconnected Voice over Internet Protocol (VoIP) service the discontinuance obligations that apply to domestic... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 63 IP-Enabled Services AGENCY: Federal Communications Commission ACTION: Final rule...

  13. Performance of VoIP on HSDPA

    DEFF Research Database (Denmark)

    Wang, Bang; Pedersen, Klaus I.; Kolding, Troels E.

    2005-01-01

    scheduler design incorporating VoIP packet aggregation and user multiplexing is proposed and the VoIP capacity is studied for a macro-cellular environment. Results are obtained for different delay budgets and packet scheduling settings, using either blind round robin or a slightly modified version...

  14. Lattice-Strain Control of Exceptional Activity in Dealloyed Core-Shell Fuel Cell Catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Strasser, Peter

    2011-08-19

    We present a combined experimental and theoretical approach to demonstrate how lattice strain can be used to continuously tune the catalytic activity of the oxygen reduction reaction (ORR) on bimetallic nanoparticles that have been dealloyed. The sluggish kinetics of the ORR is a key barrier to the adaptation of fuel cells and currently limits their widespread use. Dealloyed Pt-Cu bimetallic nanoparticles, however, have been shown to exhibit uniquely high reactivity for this reaction. We first present evidence for the formation of a core-shell structure during dealloying, which involves removal of Cu from the surface and subsurface of the precursor nanoparticles. We then show that the resulting Pt-rich surface shell exhibits compressive strain that depends on the composition of the precursor alloy. We next demonstrate the existence of a downward shift of the Pt d-band, resulting in weakening of the bond strength of intermediate oxygenated species due to strain. Finally, we combine synthesis, strain, and catalytic reactivity in an experimental/theoretical reactivity-strain relationship which provides guidelines for the rational design of strained oxygen reduction electrocatalysts. The stoichiometry of the precursor, together with the dealloying conditions, provides experimental control over the resulting surface strain and thereby allows continuous tuning of the surface electrocatalytic reactivity - a concept that can be generalized to other catalytic reactions.

  15. Cyclopentadithiophene organic core in small molecule organic solar cells: morphological control of carrier recombination.

    Science.gov (United States)

    Domínguez, Rocío; Montcada, Núria F; de la Cruz, Pilar; Palomares, Emilio; Langa, Fernando

    2017-02-01

    Two new planar and symmetrical A-D-A (electron acceptor-electron donor-electron acceptor) small molecules based on a commercial cyclopentadithiophene derivative have been synthesized for solution processed small molecule organic solar cells. The aim was to synthesise the molecules to be energetically identical (similar HOMO-LUMO energy levels) in order to assign the differences observed to changes in the film morphology or to differences in the interfacial recombination kinetics or both. Devices were electrically characterized under one sun simulated (1.5 AM G) conditions by determining current-voltage curves, light harvesting efficiencies and external quantum efficiencies. Moreover, time-resolved photo-induced techniques such as photo-induced charge extraction and photo-induced transient photo-voltage were also performed. The results demonstrate that, despite having the same core, i.e. cyclopentadithiophene, the use of one hexyl chain instead of two in the organic molecule leads to a greater control of the molecular ordering using solvent vapour annealing techniques and also to better solar cell efficiency.

  16. Core components for effective infection prevention and control programmes: new WHO evidence-based recommendations.

    Science.gov (United States)

    Storr, Julie; Twyman, Anthony; Zingg, Walter; Damani, Nizam; Kilpatrick, Claire; Reilly, Jacqui; Price, Lesley; Egger, Matthias; Grayson, M Lindsay; Kelley, Edward; Allegranzi, Benedetta

    2017-01-01

    Health care-associated infections (HAI) are a major public health problem with a significant impact on morbidity, mortality and quality of life. They represent also an important economic burden to health systems worldwide. However, a large proportion of HAI are preventable through effective infection prevention and control (IPC) measures. Improvements in IPC at the national and facility level are critical for the successful containment of antimicrobial resistance and the prevention of HAI, including outbreaks of highly transmissible diseases through high quality care within the context of universal health coverage. Given the limited availability of IPC evidence-based guidance and standards, the World Health Organization (WHO) decided to prioritize the development of global recommendations on the core components of effective IPC programmes both at the national and acute health care facility level, based on systematic literature reviews and expert consensus. The aim of the guideline development process was to identify the evidence and evaluate its quality, consider patient values and preferences, resource implications, and the feasibility and acceptability of the recommendations. As a result, 11 recommendations and three good practice statements are presented here, including a summary of the supporting evidence, and form the substance of a new WHO IPC guideline.

  17. Core components for effective infection prevention and control programmes: new WHO evidence-based recommendations

    Directory of Open Access Journals (Sweden)

    Julie Storr

    2017-01-01

    Full Text Available Abstract Health care-associated infections (HAI are a major public health problem with a significant impact on morbidity, mortality and quality of life. They represent also an important economic burden to health systems worldwide. However, a large proportion of HAI are preventable through effective infection prevention and control (IPC measures. Improvements in IPC at the national and facility level are critical for the successful containment of antimicrobial resistance and the prevention of HAI, including outbreaks of highly transmissible diseases through high quality care within the context of universal health coverage. Given the limited availability of IPC evidence-based guidance and standards, the World Health Organization (WHO decided to prioritize the development of global recommendations on the core components of effective IPC programmes both at the national and acute health care facility level, based on systematic literature reviews and expert consensus. The aim of the guideline development process was to identify the evidence and evaluate its quality, consider patient values and preferences, resource implications, and the feasibility and acceptability of the recommendations. As a result, 11 recommendations and three good practice statements are presented here, including a summary of the supporting evidence, and form the substance of a new WHO IPC guideline.

  18. Controlled-release and preserved bioactivity of proteins from (self-assembled core-shell double-walled microspheres

    Directory of Open Access Journals (Sweden)

    Yuan W

    2012-01-01

    Full Text Available Weien Yuan1,2, Zhenguo Liu11Department of Neurology, Xinhua Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 2School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaAbstract: In order to address preserved protein bioactivities and protein sustained-release problems, a method for preparing double-walled microspheres with a core (protein-loaded nanoparticles with a polymer-suspended granule system-formed core and a second shell (a polymer-formed shell for controlled drug release and preserved protein bioactivities has been developed using (solid-in-oil phase-in-hydrophilic oil-in-water (S/O/Oh/W phases. The method, based on our previous microsphere preparation method (solid-in-oil phase-in-hydrophilic oil-in-water (S/O/Oh/W, employs different concentric poly(D,L-lactide-co-glycolide, poly(D,L-lactide, and protein-loaded nanoparticles to produce a suspended liquid which then self-assembles to form shell-core microspheres in the hydrophilic oil phase, which are then solidified in the water phase. Variations in the preparation parameters allowed complete encapsulation by the shell phase, including the efficient formation of a poly(D,L-lactide shell encapsulating a protein-loaded nanoparticle-based poly(D,L-lactide-co-glycolide core. This method produces core-shell double-walled microspheres that show controlled protein release and preserved protein bioactivities for 60 days. Based upon these results, we concluded that the core-shell double-walled microspheres might be applied for tissue engineering and therapy for chronic diseases, etc.Keywords: protein delivery, protein stability, core-shell microspheres, dextran nanoparticles

  19. Antiplatelet activity of inositol hexaphosphate (IP6).

    Science.gov (United States)

    Vucenik, I; Podczasy, J J; Shamsuddin, A M

    1999-01-01

    Platelet adhesion to endothelial cells, their aggregation and subsequent release of platelet-derived mediators are key steps in the pathogenesis of thrombosis and atherosclerosis. Using impedance technology the effect of inositol hexaphosphate (IP6) on platelet aggregation and adenosine triphosphate (ATP) release were simultaneously measured in whole blood obtained from healthy volunteers (n = 10). The platelets were activated with adenosine diphosphate (ADP) (10 microM), collagen (2 micrograms/mL), or thrombin (1 U/mL) in the presence or absence of IP6. IP6 significantly inhibited platelet aggregation induced with all agonists in a dose-response manner (p IP6 strongly and significantly reduced agonist-induced ATP release (p = 0.00247 for ADP; p = 0.0074 for collagen; p = 0.0069 for thrombin). These data demonstrate that IP6 effectively inhibits human platelet aggregation in vitro, suggesting its potential in reducing the risk for cardiovascular disease.

  20. Multifunctional Au-Fe3O4@MOF core-shell nanocomposite catalysts with controllable reactivity and magnetic recyclability

    Science.gov (United States)

    Ke, Fei; Wang, Luhuan; Zhu, Junfa

    2014-12-01

    The recovery and reuse of expensive catalysts are important in both heterogeneous and homogeneous catalysis due to economic and environmental reasons. This work reports a novel multifunctional magnetic core-shell gold catalyst which can be easily prepared and shows remarkable catalytic properties in the reduction of 4-nitrophenol. The novel Au-Fe3O4@metal-organic framework (MOF) catalyst consists of a superparamagnetic Au-Fe3O4 core and a porous MOF shell with controllable thickness. Small Au nanoparticles (NPs) of 3-5 nm are mainly sandwiched between the Fe3O4 core and the porous MOF shell. Catalytic studies show that the core-shell structured Au-Fe3O4@MOF catalyst has a much higher catalytic activity than other reported Au-based catalysts toward the reduction of 4-nitrophenol. Moreover, this catalyst can be easily recycled due to the presence of the superparamagnetic core. Therefore, compared to conventional catalysts used in the reduction of 4-nitrophenol, this porous MOF-based magnetic catalyst is green, cheap and promising for industrial applications.The recovery and reuse of expensive catalysts are important in both heterogeneous and homogeneous catalysis due to economic and environmental reasons. This work reports a novel multifunctional magnetic core-shell gold catalyst which can be easily prepared and shows remarkable catalytic properties in the reduction of 4-nitrophenol. The novel Au-Fe3O4@metal-organic framework (MOF) catalyst consists of a superparamagnetic Au-Fe3O4 core and a porous MOF shell with controllable thickness. Small Au nanoparticles (NPs) of 3-5 nm are mainly sandwiched between the Fe3O4 core and the porous MOF shell. Catalytic studies show that the core-shell structured Au-Fe3O4@MOF catalyst has a much higher catalytic activity than other reported Au-based catalysts toward the reduction of 4-nitrophenol. Moreover, this catalyst can be easily recycled due to the presence of the superparamagnetic core. Therefore, compared to conventional

  1. Core-shell conjugated microporous polymers: a new strategy for exploring color-tunable and -controllable light emissions.

    Science.gov (United States)

    Xu, Yanhong; Nagai, Atsushi; Jiang, Donglin

    2013-02-25

    A core-shell strategy is demonstrated for designing a conjugated microporous polymer that allows the tuning of light emission over a wide wavelength range in a controlled manner. The polymers not only emit efficiently with an eight-fold enhanced luminescence but also sustain light emissions, irrespective of solvent and state.

  2. Heat Removal Performance of Hybrid Control Rod for Passive In-Core Cooling System

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyung Mo; Jeong, Yeong Shin; Kim, In Guk; Bang, In Cheol [UNIST, Ulsan (Korea, Republic of)

    2015-10-15

    The two-phase closed heat transfer device can be divided by thermosyphon heat pipe and capillary wicked heat pipe which uses gravitational force or capillary pumping pressure as a driving force of the convection of working fluid. If there is a temperature difference between reactor core and ultimate heat sink, the decay heat removal and reactor shutdown is possible at any accident conditions without external power sources. To apply the hybrid control rod to the commercial nuclear power plants, its modelling about various parameters is the most important work. Also, its unique geometry is coexistence of neutron absorber material and working fluid in a cladding material having annular vapor path. Although thermosyphon heat pipe (THP) or wicked heat pipe (WHP) shows high heat transfer coefficients for limited space, the maximum heat removal capacity is restricted by several phenomena due to their unique heat transfer mechanism. Validation of the existing correlations on the annular vapor path thermosyphon (ATHP) which has different wetted perimeter and heated diameter must be conducted. The effect of inner structure, and fill ratio of the working fluid on the thermal performance of heat pipe has not been investigated. As a first step of the development of hybrid heat pipe, the ATHP which contains neutron absorber in the concentric thermosyphon (CTHP) was prepared and the thermal performance of the annular thermosyphon was experimentally studied. The heat transfer characteristics and flooding limit of the annular vapor path thermosyphon was studied experimentally to model the performance of hybrid control rod. The following results were obtained: (1) The annular vapor path thermosyphon showed better evaporation heat transfer due to the enhanced convection between adiabatic and condenser section. (2) Effect of fill ratio on the heat transfer characteristics was negligible. (3) Existing correlations about flooding limit of thermosyphon could not reflect the annular vapor

  3. Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

    OpenAIRE

    Zhu, Qingzhang; Ghoshal, Sarbani; Tyagi, Richa; Chakraborty, Anutosh

    2017-01-01

    Objective: IP6 kinases (IP6Ks) regulate cell metabolism and survival. Mice with global (IP6K1-KO) or adipocyte-specific (AdKO) deletion of IP6K1 are protected from diet induced obesity (DIO) at ambient (23 °C) temperature. AdKO mice are lean primarily due to increased AMPK mediated thermogenic energy expenditure (EE). Thus, at thermoneutral (30 °C) temperature, high fat diet (HFD)-fed AdKO mice expend energy and gain body weight, similar to control mice. IP6K1 is ubiquitously expressed; thus,...

  4. Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.

    Science.gov (United States)

    Vucenik, Ivana; Shamsuddin, AbulKalam M

    2003-11-01

    Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that is present in substantial amounts in almost all plant and mammalian cells. It was recently recognized to possess multiple biological functions. A striking anticancer effect of IP6 was demonstrated in different experimental models. Inositol is also a natural constituent possessing moderate anticancer activity. The most consistent and best anticancer results were obtained from the combination of IP6 plus inositol. In addition to reducing cell proliferation, IP6 increases differentiation of malignant cells, often resulting in a reversion to normal phenotype. Exogenously administered IP6 is rapidly taken into the cells and dephosphorylated to lower-phosphate inositol phosphates, which further interfere with signal transduction pathways and cell cycle arrest. Enhanced immunity and antioxidant properties can also contribute to tumor cell destruction. However, the molecular mechanisms underlying this anticancer action are not fully understood. Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP6 holds great promise in our strategies for the prevention and treatment of cancer. IP6 plus inositol enhances the anticancer effect of conventional chemotherapy, controls cancer metastases, and improves the quality of life, as shown in a pilot clinical trial. The data strongly argue for the use of IP6 plus inositol in our strategies for cancer prevention and treatment. However, the effectiveness and safety of IP6 plus inositol at therapeutic doses needs to be determined in phase I and phase II clinical trials in humans.

  5. Analyzing the trade-off between multiple memory controllers and memory channels on multi-core processor performance

    Energy Technology Data Exchange (ETDEWEB)

    Sancho Pitarch, Jose Carlos [Los Alamos National Laboratory; Kerbyson, Darren [Los Alamos National Laboratory; Lang, Mike [Los Alamos National Laboratory

    2010-01-01

    Increasing the core-count on current and future processors is posing critical challenges to the memory subsystem to efficiently handle concurrent memory requests. The current trend to cope with this challenge is to increase the number of memory channels available to the processor's memory controller. In this paper we investigate the effectiveness of this approach on the performance of parallel scientific applications. Specifically, we explore the trade-off between employing multiple memory channels per memory controller and the use of multiple memory controllers. Experiments conducted on two current state-of-the-art multicore processors, a 6-core AMD Istanbul and a 4-core Intel Nehalem-EP, for a wide range of production applications shows that there is a diminishing return when increasing the number of memory channels per memory controller. In addition, we show that this performance degradation can be efficiently addressed by increasing the ratio of memory controllers to channels while keeping the number of memory channels constant. Significant performance improvements can be achieved in this scheme, up to 28%, in the case of using two memory controllers with each with one channel compared with one controller with two memory channels.

  6. Securing VoIP keeping your VoIP network safe

    CERN Document Server

    (Bud) Bates, Regis J Jr

    2015-01-01

    Securing VoIP: Keeping Your VoIP Network Safe will show you how to take the initiative to prevent hackers from recording and exploiting your company's secrets. Drawing upon years of practical experience and using numerous examples and case studies, technology guru Bud Bates discusses the business realities that necessitate VoIP system security and the threats to VoIP over both wire and wireless networks. He also provides essential guidance on how to conduct system security audits and how to integrate your existing IT security plan with your VoIP system and security plans, helping you prevent

  7. Space Network IP Services (SNIS): An Architecture for Supporting Low Earth Orbiting IP Satellite Missions

    Science.gov (United States)

    Israel, David J.

    2005-01-01

    The NASA Space Network (SN) supports a variety of missions using the Tracking and Data Relay Satellite System (TDRSS), which includes ground stations in White Sands, New Mexico and Guam. A Space Network IP Services (SNIS) architecture is being developed to support future users with requirements for end-to-end Internet Protocol (IP) communications. This architecture will support all IP protocols, including Mobile IP, over TDRSS Single Access, Multiple Access, and Demand Access Radio Frequency (RF) links. This paper will describe this architecture and how it can enable Low Earth Orbiting IP satellite missions.

  8. Controllable modification of nanostructured carbon with hollow macroporous core/mesoporous shell and its application as templates in aqueous solution

    Science.gov (United States)

    Ren, Xiaona; Xia, Min; Yan, Qingzhi; Ge, Changchun

    2016-10-01

    Controllable modification of hydrophilic groups on tubular nanostructured carbon with hollow macroporous core/mesoporous shell (TNC-HMC/MS) was systematically studied and the mesoporous structure of TNC-HMC/MS has been kept. Different oxidants were used to modify the TNC-HMC/MS. Results revealed that the TNC-HMC/MS could be modified with carboxyl or hydroxy by different oxidants. More importantly, the BET/BJH results indicated that the mesoporous shell of TNC-HMC/MS has not been destroyed. In addition, water-soluble ammonium metatungstate has been encapsulated into the hollow core of TNC-HMC/MS and formed nanodot, bamboo-like and nanowire morphology.

  9. 基于QoS的IP VPN的研究%A QoS-Based IP VPN Architecture Research

    Institute of Scientific and Technical Information of China (English)

    李振东; 谢立

    2003-01-01

    Constructing Virtual Private Network (VPN) over public network infrastructure (Internet) is becoming the foundation of the next generation network service. At present, VPN mainly focuses on the security property, while it is lack of consideration of QoS. On the basis of analyzing the Differentiated Services (Diffserv) and IPsec, we put forward a QoS-based IP VPN Architecture Model which is a tri-tier model that is composed of ESN, ISN and VPN node. It combines encrypted channel mechanism of IPsec and the edge-and-core-model of Diffserv. It provides end-to-end QoS while assures security.

  10. Comprehensive Comparison of VoIP SIP Protocol Problems and Cisco VoIP System

    Directory of Open Access Journals (Sweden)

    TALAL AL-KHAROBI

    2012-08-01

    Full Text Available Voice over IP (VoIP, use of the packet switched internet for telephony, has improved substantially in the past few years. On the other hand, VoIP has many challenges that do not exist in the public switched telephone network (PSTN, a circuit switched system. VoIP is an application running on the internet, and therefore inherits the internet’s security issues. It is important to realise that VoIP is a relatively young technology, and with any new technology, security typically improves with maturity. This paper provides a comprehensive comparison of a VoIP SIP protocol and CISCO VoIP system. The comparison involves the investigation of the vulnerabilities that target both systems and how secure each system is. With this comparison we present our conclusion on which system is more secure.

  11. Training infection control and hospital hygiene professionals in Europe, 2010: agreed core competencies among 33 European countries.

    Science.gov (United States)

    Brusaferro, S; Cookson, B; Kalenic, S; Cooper, T; Fabry, J; Gallagher, R; Hartemann, P; Mannerquist, K; Popp, W; Privitera, G; Ruef, C; Viale, P; Coiz, F; Fabbro, E; Suetens, C; Varela Santos, C

    2014-12-11

    The harmonisation of training programmes for infection control and hospital hygiene (IC/HH) professionals in Europe is a requirement of the Council recommendation on patient safety. The European Centre for Disease Prevention and Control commissioned the 'Training Infection Control in Europe' project to develop a consensus on core competencies for IC/HH professionals in the European Union (EU). Core competencies were drafted on the basis of the Improving Patient Safety in Europe (IPSE) project's core curriculum (CC), evaluated by questionnaire and approved by National Representatives (NRs) for IC/HH training. NRs also re-assessed the status of IC/HH training in European countries in 2010 in comparison with the situation before the IPSE CC in 2006. The IPSE CC had been used to develop or update 28 of 51 IC/HH courses. Only 10 of 33 countries offered training and qualification for IC/HH doctors and nurses. The proposed core competencies are structured in four areas and 16 professional tasks at junior and senior level. They form a reference for standardisation of IC/HH professional competencies and support recognition of training initiatives.

  12. Active Network Supports for Mobile IP

    Institute of Scientific and Technical Information of China (English)

    LU Yueming; QIAN Depei; XU Bin; WANG Lei

    2001-01-01

    The basic mobile IP protocol is difficult to implement on the traditional IP network and not flexible and efficient under certain conditions. For example, firewalls or boundary routers may drop packets sent by mobile nodes for security reasons. Traditional networking devices such as routers cannot dynamically load and unload extended services to achieve different qualities of services. In this paper, a new scheme of using the active network to support the mobile IP is presented. The Softnet, a prototype of active networks based on mobile agents,is introduced. The active network is characterized by the programmability of its intermediatenodes and therefore presents dynamic and flexible behaviors. Special services can be dynamically deployed onto the active nodes in the Softnet. This property is definitely required in implementing the mobile IP protocols. The Softnet supports not only the basic mobile IP protocol but also other extended mobile IP protocols. Virtual networks for mobile IP services are dynamically formed by mobile agents in the Softnet to provide different qualities of services.

  13. What are suspicious VoIP delays?

    CERN Document Server

    Mazurczyk, Wojciech; Szczypiorski, Krzysztof

    2010-01-01

    Voice over IP (VoIP) is unquestionably the most popular real-time service in IP networks today. Recent studies have shown that it is also a suitable carrier for information hiding. Hidden communication may pose security concerns as it can lead to confidential information leakage. In VoIP, RTP (Real-time Transport Protocol) in particular, which provides the means for the successful transport of voice packets through IP networks, is suitable for steganographic purposes. It is characterised by a high packet rate compared to other protocols used in IP telephony, resulting in a potentially high steganographic bandwidth. The modification of an RTP packet stream provides many opportunities for hidden communication as the packets may be delayed, reordered or intentionally lost. In this paper, to enable the detection of steganographic exchanges in VoIP, we examined real RTP traffic traces to answer the questions, what do the "normal" delays in RTP packet streams look like? and, is it possible to detect the use of know...

  14. Microstructural control in an aluminum core alloy for brazing sheet applications

    Science.gov (United States)

    Marshall, G. J.; Bolingbroke, R. K.; Gray, A.

    1993-09-01

    The use of aluminum alloys for automotive heat exchangers has increased considerably in the last 15 to 20 years, and in parallel, new alloys have been developed to meet the increased demand for higher strengths and improved corrosion resistance. An Al-Mn alloy, X800, has been developed by Alcan to significantly increase the corrosion resistance of radiator tubes when subjected to typical service environments. Conventional alloy tubes, 3xxx or 6xxx, fail by intergranular attack, whereas X800 utilizes the diffusion of Si during brazing to form a sacrificial layer between core and cladding and thus prevent penetration through the core. The Si penetrates up to a depth of 70 µm into the core alloy and combines with both the Mn in solid solution and the coarse constituent particles to form the α-AlMnSi phase. In contrast to the core, the interface layer exhibits a high dispersoid density, a modified coarse particle chemistry, and a lower Mn level in solid solution after brazing. Three layers remain after brazing; an α-Al residual cladding, the interface layer with a band of dense precipitates (BDP), and the X800 core. Free corrosion potential measurements confirmed the lowering of the potential within the BDP by about 30 mV compared to —710 mV for the brazed X800 core.

  15. Rab33B Controls Hepatitis B Virus Assembly by Regulating Core Membrane Association and Nucleocapsid Processing.

    Science.gov (United States)

    Bartusch, Christina; Döring, Tatjana; Prange, Reinhild

    2017-06-21

    Many viruses take advantage of cellular trafficking machineries to assemble and release new infectious particles. Using RNA interference (RNAi), we demonstrate that the Golgi/autophagosome-associated Rab33B is required for hepatitis B virus (HBV) propagation in hepatoma cell lines. While Rab33B is dispensable for the secretion of HBV subviral envelope particles, its knockdown reduced the virus yield to 20% and inhibited nucleocapsid (NC) formation and/or NC trafficking. The overexpression of a GDP-restricted Rab33B mutant phenocopied the effect of deficit Rab33B, indicating that Rab33B-specific effector proteins may be involved. Moreover, we found that HBV replication enhanced Rab33B expression. By analyzing HBV infection cycle steps, we identified a hitherto unknown membrane targeting module in the highly basic C-terminal domain of the NC-forming core protein. Rab33B inactivation reduced core membrane association, suggesting that membrane platforms participate in HBV assembly reactions. Biochemical and immunofluorescence analyses provided further hints that the viral core, rather than the envelope, is the main target for Rab33B intervention. Rab33B-deficiency reduced core protein levels without affecting viral transcription and hampered core/NC sorting to envelope-positive, intracellular compartments. Together, these results indicate that Rab33B is an important player in intracellular HBV trafficking events, guiding core transport to NC assembly sites and/or NC transport to budding sites.

  16. Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play.

    Science.gov (United States)

    Manduca, Antonia; Lassalle, Olivier; Sepers, Marja; Campolongo, Patrizia; Cuomo, Vincenzo; Marsicano, Giovanni; Kieffer, Brigitte; Vanderschuren, Louk J M J; Trezza, Viviana; Manzoni, Olivier J J

    2016-01-01

    Social play behavior is a highly rewarding, developmentally important form of social interaction in young mammals. However, its neurobiological underpinnings remain incompletely understood. Previous work has suggested that opioid and endocannabinoid neurotransmission interact in the modulation of social play. Therefore, we combined behavioral, pharmacological, electrophysiological, and genetic approaches to elucidate the role of the endocannabinoid 2-arachidonoylglycerol (2-AG) in social play, and how cannabinoid and opioid neurotransmission interact to control social behavior in adolescent rodents. Systemic administration of the 2-AG hydrolysis inhibitor JZL184 or the opioid receptor agonist morphine increased social play behavior in adolescent rats. These effects were blocked by systemic pretreatment with either CB1 cannabinoid receptor (CB1R) or mu-opioid receptor (MOR) antagonists. The social play-enhancing effects of systemic morphine or JZL184 treatment were also prevented by direct infusion of the CB1R antagonist SR141716 and the MOR antagonist naloxone into the nucleus accumbens core (NAcC). Searching for synaptic correlates of these effects in adolescent NAcC excitatory synapses, we observed that CB1R antagonism blocked the effect of the MOR agonist DAMGO and, conversely, that naloxone reduced the effect of a cannabinoid agonist. These results were recapitulated in mice, and completely abolished in CB1R and MOR knockout mice, suggesting that the functional interaction between CB1R and MOR in the NAcC in the modulation of social behavior is widespread in rodents. The data shed new light on the mechanism by which endocannabinoid lipids and opioid peptides interact to orchestrate rodent socioemotional behaviors.

  17. Interacting cannabinoid and opioid receptors in the nucleus accumbens core control adolescent social play

    Directory of Open Access Journals (Sweden)

    Antonia Manduca

    2016-11-01

    Full Text Available Social play behavior is a highly rewarding, developmentally important form of social interaction in young mammals. However, its neurobiological underpinnings remain incompletely understood. Previous work has suggested that opioid and endocannabinoid neurotransmission interact in the modulation of social play. Therefore, we combined behavioral, pharmacological, electrophysiological and genetic approaches to elucidate the role of the endocannabinoid 2-arachidonoylglycerol (2-AG in social play, and how cannabinoid and opioid neurotransmission interact to control social behavior in adolescent rodents. Systemic administration of the 2-AG hydrolysis inhibitor JZL184 or the opioid receptor agonist morphine increased social play behavior in adolescent rats. These effects were blocked by systemic pretreatment with either CB1 cannabinoid receptor (CB1R or mu-opioid receptor (MOR antagonists. The social play-enhancing effects of systemic morphine or JZL184 treatment were also prevented by direct infusion of the CB1R antagonist SR141716 and the MOR antagonist naloxone into the nucleus accumbens core (NAcC. Searching for synaptic correlates of these effects in adolescent NAcC excitatory synapses, we observed that CB1R antagonism blocked the effect of the MOR agonist DAMGO and, conversely, that naloxone reduced the effect of a cannabinoid agonist. These results were recapitulated in mice, and completely abolished in CB1R and MOR knockout mice, suggesting that the functional interaction between CB1R and MOR in the NAcC in the modulation of mediates social behavior is widespread in rodents. The data shed new light on the mechanism by which endocannabinoid lipids and opioid peptides interact to orchestrate rodent socioemotional behaviors.

  18. Development of Electrostatically Enhanced Core Separater for Particulate Air Toxics Control

    Energy Technology Data Exchange (ETDEWEB)

    Eason, B.H.; Smolensky, L.A.; Wysk, S.R.; Altman, R.F.; Harrison, W.A.; Hardman, R.R.

    1997-12-31

    The Clean Air Act Amendments of 1990 have identified 189 chemical elements and compounds as hazardous air pollutants (HAPs). The U.S. Environmental Protection Agency (EPA) has been given the task of evaluating the health risks of these so-called air toxics and determining their acceptable emission rates. The U.S. Department of Energy (DOE), in cooperation with private industry, is sponsoring research into developing new air toxic emission control technologies. Coal typically contains trace amounts of HAPS, the species and amounts vary with coal type and source. Combustion of coal in Fossil Energy Power Systems releases these HAPs into the combustion gas where they flow to the stack by passing through the gas cleanup system. Except for mercury and selenium, the HAPs exist primarily in the solid phase temperatures typical of flue gases so they can be removed by particulate cleanup systems. In fact, these solid phase HAPs are removed with approximately the same efficiency as the other particulate matter. Table 1 shows the removal efficiency of 15 HAPs by an electrostatic precipitator having an efficiency of approximately 99 percent. These results suggest that very high removal efficiencies of particulate HAPs can be achieved by using a very high efficiency particulate collector. Epidemiological studies` suggest that there may be health benefits from reducing concentrations of particulate matter in the ambient air. This paper will discuss the development of a very high efficiency particulate collector called the Electrostatically Enhanced Core Separator (EECS) system that may have the potential to significantly reduce the emission rates of both particulates and particulate air toxics from Fossil Energy Power Systems.

  19. Synthesis and Control of the Shell Thickness of Polyaniline and Polypyrrole Half Hollow Spheres Using the Polystyrene Cores

    Directory of Open Access Journals (Sweden)

    Su-Ryeon Yun

    2012-01-01

    Full Text Available Polyaniline (Pani and polypyrrole (Ppy half hollow spheres with different shell thicknesses were successfully synthesized by three steps process using polystyrene (PS as the core. The PS core was synthesized by emulsion polymerization. Aniline and pyrrole monomers were polymerized on the surface of the PS core. The shells of Pani and Ppy were fabricated by adding different amounts of aniline and pyrrole monomers. PS cores were dissolved and removed from the core shell structure by solvent extraction. The thicknesses of the Pani and Ppy half hollow spheres were observed by FE-SEM and FE-TEM. The chemical structures of the Pani and Ppy half hollow spheres were characterized by FT-IR spectroscopy and UV-Vis spectroscopy. The shell thicknesses of the Pani half hollow spheres were 30.2, 38.0, 42.2, 48.2, and 52.4 nm, while the shell thicknesses of the Ppy half hollow spheres were 16.0, 22.0, 27.0, and 34.0 nm. The shell thicknesses of Pani and Ppy half hollow spheres linearly increased as the amount of the monomer increased. Therefore, the shell thickness of the Pani and Ppy half hollow spheres can be controlled in these ranges.

  20. Multifunctional Au-Fe3O4@MOF core-shell nanocomposite catalysts with controllable reactivity and magnetic recyclability.

    Science.gov (United States)

    Ke, Fei; Wang, Luhuan; Zhu, Junfa

    2015-01-21

    The recovery and reuse of expensive catalysts are important in both heterogeneous and homogeneous catalysis due to economic and environmental reasons. This work reports a novel multifunctional magnetic core-shell gold catalyst which can be easily prepared and shows remarkable catalytic properties in the reduction of 4-nitrophenol. The novel Au-Fe3O4@metal-organic framework (MOF) catalyst consists of a superparamagnetic Au-Fe3O4 core and a porous MOF shell with controllable thickness. Small Au nanoparticles (NPs) of 3-5 nm are mainly sandwiched between the Fe3O4 core and the porous MOF shell. Catalytic studies show that the core-shell structured Au-Fe3O4@MOF catalyst has a much higher catalytic activity than other reported Au-based catalysts toward the reduction of 4-nitrophenol. Moreover, this catalyst can be easily recycled due to the presence of the superparamagnetic core. Therefore, compared to conventional catalysts used in the reduction of 4-nitrophenol, this porous MOF-based magnetic catalyst is green, cheap and promising for industrial applications.

  1. Preliminary Test of a small heat pipe for hybrid control rod in-core passive decay heat removal system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Guk; Ban, In Cheol [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)

    2014-05-15

    This paper introduces 'Hybrid control rod' combining its original function and heat removal ability. The high temperature operation and high resistance of radiation should be considered to adopt the hybrid heat pipe at the in-core condition. Other design consideration is to make extra inlet parts because it has a high risk of inlet boundary failure. It means that the introduction of heat pipe system is difficult to present nuclear power plants. The other concepts are presented to out-core cooling design but it has low performance compared with in-core heat removal system. Hybrid heat pipe for in-core heat removal system suggests the solution of these problems. Ultimate objective of this research is to develop the passive emergency decay heat removal system using hybrid heat pipes targeting design bases accidents such as station black-out (SBO) and small break loss of coolant accident (SBLOCA). The purpose of this work is to confirm the performance and heat transfer behavior of hybrid heat pipe. The hybrid heat pipe has special condition for operation. Therefore, it is hard to analyze their behavior in core. Table I shows the characteristics of hybrid heat pipe and consideration for manufacturing the heat pipe.

  2. UVEDBA IP TELEFONIJE V MEDNARODNO PODJETJE

    OpenAIRE

    Goršič, Matej

    2009-01-01

    Diploma opisuje postopen prehod iz klasičnega tipa telefonije na IP (Internet Protocol) telefonijo. To je korak, ki so ga mnoga podjetja v svetu že opravila, veliko jih pa še čaka. Predstavili bomo ozadje klasične in IP telefonije ter osnovne gradnike. Poskušali bomo pojasniti, zakaj je zdaj pravi trenutek za ta prehod ter kaj potrebujemo, morda pa bomo tudi koga opogumili za podoben poseg. Opisan je postopni prehod na IP telefonijo. To pomeni, da v prvem koraku še obdržimo klasično centr...

  3. IP Address Management Principles and Practice

    CERN Document Server

    Rooney, Timothy

    2010-01-01

    This book will be the first covering the subject of IP address management (IPAM). The practice of IPAM includes the application of network management disciplines to IP address space and associated network services, namely DHCP (Dynamic Host Configuration Protocol) and DNS (Domain Name System). The consequence of inaccurately configuring DHCP is that end users may not be able to obtain IP addresses to access the network. Without proper DNS configuration, usability of the network will greatly suffer as the name-to-address lookup process may fail. Imagine having to navigate to a website or send a

  4. TCP-IP Model in Data Communication and Networking

    Directory of Open Access Journals (Sweden)

    Pranab Bandhu Nath

    2015-10-01

    Full Text Available The Internet protocol suite is the computer networking model and set of communications protocols used on the Internet and similar computer networks. It is commonly known as TCP/IP, because it’s most important protocols, the Transmission Control Protocol (TCP and the Internet Protocol (IP, were the first networking protocols defined in this standard. Often also called the Internet model, it was originally also known as the DoD model, because the development of the networking model was funded by DARPA, an agency of the United States Department of Defense. TCP/IP provides end-to-end connectivity specifying how data should be packetized, addressed, transmitted, routed and received at the destination. This functionality is organized into four abstraction layers which are used to sort all related protocols according to the scope of networking involved. From lowest to highest, the layers are the link layer, containing communication technologies for a single network segment (link; the internet layer, connecting hosts across independent networks, thus establishing internetworking; the transport layer handling host-to-host communication; and the application layer, which provides process-to-process application data exchange. Our aim is describe operation & models of TCP-IP suite in data communication networking

  5. 落叶松八齿小蠹伴生真菌富士长喙壳的防治研究%Research on Control of Fungus Associated with Ips subelongatus

    Institute of Scientific and Technical Information of China (English)

    周秀华; 崔磊; 宋瑞清

    2011-01-01

    Screening of antagonistic fungi and fungicide against fungus (Ceratocystis fujiensis) associated with Ips subelongatus was performed to provide an important theoretical basis for exploring sustainable control of the associated fungus. The antagonistic culture was performed on 22 antagonistic fungus and 3 strains of associated fungus(CFl,CF2,CF3) ,and the antagonistic fungi of which relative inhibition effect was more than 3. 00 were screened;3 strains for CF1,8 strains for CF2,and 4 stains for CF3. In the antagonistic culture,Bipolaris sorokiniana showed the significant antagonistic effect and the growth rate of its own was promoted. Fifteen types of fungicides were tested in this research and 10 types were screened out based on inhibition rates of more than 50% against 3 strains of C. Fujiensis. The order of resistance to fungicides was CF3>CF2>CF1.%筛选落叶松八齿小蠹伴生真菌富士长喙壳(Ceratoc ystis uj iensis)的拮抗菌株和杀菌剂,旨在为该伴生真菌的生物防治和化学防治提供科学依据.通过22个菌株与3株富士长喙壳(CF1、CF2、CF3)的拮抗培养,筛选出相对抑制效果在3.00以上的拮抗菌:CF1有3株,CF2有8株,CF3有4株.菌株Bipolaris sorokiniana在拮抗培养中,自身的生长速率被促进,说明其拮抗效果明显.在所选用的15种杀菌剂中,10种杀菌剂对3株富士长喙壳生长抑制率大于50%,3个菌株抗药性的强弱能力为:CF3>CF2>CF1.

  6. Extraction Of Electronic Evidence From VoIP: Identification & Analysis Of Digital Speech

    Directory of Open Access Journals (Sweden)

    David Irwin

    2012-09-01

    Full Text Available The Voice over Internet Protocol (VoIP is increasing in popularity as a cost effective and efficient means of making telephone calls via the Internet. However, VoIP may also be an attractive method of communication to criminals as their true identity may be hidden and voice and video communications are encrypted as they are deployed across the Internet. This produces in a new set of challenges for forensic analysts compared with traditional wire-tapping of the Public Switched Telephone Network (PSTN infrastructure, which is not applicable to VoIP. Therefore, other methods of recovering electronic evidence from VoIP are required.  This research investigates the analysis and recovery of digitised human, which persists in computer memory after a VoIP call.This paper proposes a proof of concept how remnants of digitised human speech from a VoIP call may be identified within a forensic memory capture based on how the human voice is detected via a microphone and encoded to a digital format using the sound card of your personal computer. This digital format is unencrypted whist processed in Random Access Memory (RAM before it is passed to the VoIP application for encryption and  transmission over the Internet. Similarly, an incoming encrypted VoIP call is decrypted by the VoIP application and passes through RAM unencrypted in order to be played via the speaker output.A series of controlled tests were undertaken whereby RAM captures were analysed for remnants of digital speech after a VoIP audio call with known conversation. The identification and analysis of digital speech from RAM attempts to construct an automatic process for the identification and subsequent reconstruction of the audio content of a VoIP call.

  7. ExpressionofCXCchemokineIP-10in patients with chronic hepatitis B

    Institute of Scientific and Technical Information of China (English)

    Jian Wang; Jin-Hong Zhao; Ping-Ping Wang; Gui-Ju Xiang

    2008-01-01

    BACKGROUND:Chemokines have strong chemoattractant effects and are involved in a variety of immune and inlfammatory reactions, such as attracting activated T lymphocytes, neutrophils, monocytes and natural killer cells via the pathway of G protein-coupled receptors to sites of inlfammatory injury and contribute to wound repair. This investigation was designed to assess the levels of chemokine interferon-γ inducible protein-10 (IP-10) and IP-10 mRNA, and the relationship between IP-10 mRNA and HBV-DNA and alanine aminotransferase (ALT) in patients with chronic hepatitis B. METHODS:The levels of IP-10 mRNA in peripheral blood mononuclear cells (PBMCs) were kinetically detected by real-time polymerase chain reaction (PCR). The rate of chemokine/GAPDH was regarded as the extreme level of chemokine. The level of IP-10 in serum was measured by enzyme linked immunosorbent assay (ELISA), and the expression of IP-10 in hepatic biopsy tissue was detected by streptavidin-peroxidase (SP) immunohistochemistry. RESULTS:The level of IP-10 mRNA in the PBMCs of patients was 0.7387±0.0768 (lg cDNA/lg GAPDH); it was signiifcantly higher in patients with chronic hepatitis B than that in normal controls (P CONCLUSIONS:The expression of IP-10 mRNA in PBMCs, IP-10 plasma concentration and the expression of IP-10 in sinusoidal endothelium are all high in patients with chronic hepatitis B. Chemokine IP-10 may play an important role in trafifcking inlfammatory cells to the local focus in the liver and induce the development of the chronicity of hepatitis B.

  8. Effect of superconducting solenoid model cores on spanwise iron magnet roll control

    Science.gov (United States)

    Britcher, C. P.

    1985-01-01

    Compared with conventional ferromagnetic fuselage cores, superconducting solenoid cores appear to offer significant reductions in the projected cost of a large wind tunnel magnetic suspension and balance system. The provision of sufficient magnetic roll torque capability has been a long-standing problem with all magnetic suspension and balance systems; and the spanwise iron magnet scheme appears to be the most powerful system available. This scheme utilizes iron cores which are installed in the wings of the model. It was anticipated that the magnetization of these cores, and hence the roll torque generated, would be affected by the powerful external magnetic field of the superconducting solenoid. A preliminary study has been made of the effect of the superconducting solenoid fuselage model core concept on the spanwise iron magnet roll torque generation schemes. Computed data for one representative configuration indicate that reductions in available roll torque occur over a range of applied magnetic field levels. These results indicate that a 30-percent increase in roll electromagnet capacity over that previously determined will be required for a representative 8-foot wind tunnel magnetic suspension and balance system design.

  9. Control of core argon impurity profile by ECH in KSTAR L-mode plasmas

    Science.gov (United States)

    Hong, Joohwan; Lee, Seung Hun; Kim, Juhyung; Seon, C. R.; Lee, S. G.; Park, G. Y.; Lee, K. D.; Henderson, S. S.; Lee, H. Y.; Park, Jae Sun; Jang, Juhyeok; Jang, Siwon; Jeon, Taemin; O'Mullane, M.; Choe, Wonho

    2015-06-01

    Experiments on trace argon impurity transport in L-mode discharges were performed on Korea superconducting tokamak advanced research (KSTAR) with electron cyclotron resonance heating (ECH). Ar emission was measured by soft x-ray (SXR) arrays and vacuum UV (VUV) diagnostics. A significant reduction in the core Ar emissivity was observed with core ECH. The reduction was the largest with on-axis heating and became smaller with outward heating positions. The diffusivity and convection velocity of Ar were obtained by analysis of the SXR data with the SANCO impurity transport code for the on-axis ECH and the non-ECH shots. In the on-axis ECH case, both diffusivity and convection velocity increased. Furthermore, the convection changed its direction from inward to outward in the plasma core (r/a < 0.3), resulting in a hollow profile of the total Ar density. Together with the reduction in the SXR signals, the hollow impurity profile in the core and the reversal of the convection velocity consistently confirm that ECH can reduce impurity accumulation in the core region. Neoclassical impurity transport and linear stability of micro-turbulence were calculated and discussed in relation to the possible transport mechanism.

  10. Security for IP Multimedia Services in the 3GPP Third Generation Mobile System.

    Science.gov (United States)

    Horn, G.; Kroselberg, D.; Muller, K.

    2003-01-01

    Presents an overview of the security architecture of the IP multimedia core network subsystem (IMS) of the third generation mobile system, known in Europe as UMTS. Discusses IMS security requirements; IMS security architecture; authentication between IMS user and home network; integrity and confidentiality for IMS signalling; and future aspects of…

  11. Experimental Evaluation of Tuned Chamber Core Panels for Payload Fairing Noise Control

    Science.gov (United States)

    Schiller, Noah H.; Allen, Albert R.; Herlan, Jonathan W.; Rosenthal, Bruce N.

    2015-01-01

    Analytical models have been developed to predict the sound absorption and sound transmission loss of tuned chamber core panels. The panels are constructed of two facesheets sandwiching a corrugated core. When ports are introduced through one facesheet, the long chambers within the core can be used as an array of low-frequency acoustic resonators. To evaluate the accuracy of the analytical models, absorption and sound transmission loss tests were performed on flat panels. Measurements show that the acoustic resonators embedded in the panels improve both the absorption and transmission loss of the sandwich structure at frequencies near the natural frequency of the resonators. Analytical predictions for absorption closely match measured data. However, transmission loss predictions miss important features observed in the measurements. This suggests that higher-fidelity analytical or numerical models will be needed to supplement transmission loss predictions in the future.

  12. LACK - a VoIP Steganographic Method

    CERN Document Server

    Mazurczyk, Wojciech

    2008-01-01

    The paper presents a new steganographic method called LACK (Lost Audio PaCKets Steganography) which is intended mainly for VoIP. The method is presented in a broader context of network steganography and of VoIP steganography in particular. The analytical results presented in the paper concern the influence of LACK's hidden data insertion procedure on the method's impact on quality of voice transmission and its resistance to steganalysis.

  13. An Implementation of IP-Phone Gateway

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    To implement voice service over packet-based network (Internet) and TDM-based network (PSTN Public Switched Telephone Network), an IP phone gateway is necessary to transform media stream and convert signaling protocols used over both the two networks. In this article, the architecture of the IP-Phone gateway is described firstly. Then the communications mechanism between functional blocks and multi-thread consideration are presented.

  14. Secretion of biologically active interferon-gamma inducible protein-10 (IP-10 by Lactococcus lactis

    Directory of Open Access Journals (Sweden)

    Saucedo-Cardenas Odila

    2008-07-01

    Full Text Available Abstract Background Chemokines are a large group of chemotactic cytokines that regulate and direct migration of leukocytes, activate inflammatory responses, and are involved in many other functions including regulation of tumor development. Interferon-gamma inducible-protein-10 (IP-10 is a member of the C-X-C subfamily of the chemokine family of cytokines. IP-10 specifically chemoattracts activated T lymphocytes, monocytes, and NK cells. IP-10 has been described also as a modulator of other antitumor cytokines. These properties make IP-10 a novel therapeutic molecule for the treatment of chronic and infectious diseases. Currently there are no suitable live biological systems to produce and secrete IP-10. Lactococcus lactis has been well-characterized over the years as a safe microorganism to produce heterologous proteins and to be used as a safe, live vaccine to deliver antigens and cytokines of interest. Here we report a recombinant strain of L. lactis genetically modified to produce and secrete biologically active IP-10. Results The IP-10 coding region was isolated from human cDNA and cloned into an L. lactis expression plasmid under the regulation of the pNis promoter. By fusion to the usp45 secretion signal, IP-10 was addressed out of the cell. Western blot analysis demonstrated that recombinant strains of L. lactis secrete IP-10 into the culture medium. Neither degradation nor incomplete forms of IP-10 were detected in the cell or supernatant fractions of L. lactis. In addition, we demonstrated that the NICE (nisin-controlled gene expression system was able to express IP-10 "de novo" even two hours after nisin removal. This human IP-10 protein secreted by L. lactis was biological active as demonstrated by Chemotaxis assay over human CD3+T lymphocytes. Conclusion Expression and secretion of mature IP-10 was efficiently achieved by L. lactis forming an effective system to produce IP-10. This recombinant IP-10 is biologically active as

  15. Dynamic control of higher-order modes in hollow-core photonic crystal fibers.

    Science.gov (United States)

    Euser, T G; Whyte, G; Scharrer, M; Chen, J S Y; Abdolvand, A; Nold, J; Kaminski, C F; Russell, P St J

    2008-10-27

    We present a versatile method for selective mode coupling into higher-order modes of photonic crystal fibers, using holograms electronically generated by a spatial light modulator. The method enables non-mechanical and completely repeatable changes in the coupling conditions. We have excited higher order modes up to LP(31) in hollow-core photonic crystal fibers. The reproducibility of the coupling allows direct comparison of the losses of different guided modes in both hollow-core bandgap and kagome-lattice photonic crystal fibers. Our results are also relevant to applications in which the intensity distribution of the light inside the fiber is important, such as particle- or atom-guidance.

  16. CtIP Mutations Cause Seckel and Jawad Syndromes.

    Directory of Open Access Journals (Sweden)

    Per Qvist

    2011-10-01

    Full Text Available Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. Genetically, it constitutes a heterogeneous condition, with several loci mapped (SCKL1-5 but only three disease genes identified: the ATR, CENPJ, and CEP152 genes that control cellular responses to DNA damage. We previously mapped a Seckel syndrome locus to chromosome 18p11.31-q11.2 (SCKL2. Here, we report two mutations in the CtIP (RBBP8 gene within this locus that result in expression of C-terminally truncated forms of CtIP. We propose that these mutations are the molecular cause of the disease observed in the previously described SCKL2 family and in an additional unrelated family diagnosed with a similar form of congenital microcephaly termed Jawad syndrome. While an exonic frameshift mutation was found in the Jawad family, the SCKL2 family carries a splicing mutation that yields a dominant-negative form of CtIP. Further characterization of cell lines derived from the SCKL2 family revealed defective DNA damage induced formation of single-stranded DNA, a critical co-factor for ATR activation. Accordingly, SCKL2 cells present a lowered apoptopic threshold and hypersensitivity to DNA damage. Notably, over-expression of a comparable truncated CtIP variant in non-Seckel cells recapitulates SCKL2 cellular phenotypes in a dose-dependent manner. This work thus identifies CtIP as a disease gene for Seckel and Jawad syndromes and defines a new type of genetic disease mechanism in which a dominant negative mutation yields a recessively inherited disorder.

  17. CtIP Mutations Cause Seckel and Jawad Syndromes.

    Directory of Open Access Journals (Sweden)

    Per Qvist

    2011-10-01

    Full Text Available Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. Genetically, it constitutes a heterogeneous condition, with several loci mapped (SCKL1-5 but only three disease genes identified: the ATR, CENPJ, and CEP152 genes that control cellular responses to DNA damage. We previously mapped a Seckel syndrome locus to chromosome 18p11.31-q11.2 (SCKL2. Here, we report two mutations in the CtIP (RBBP8 gene within this locus that result in expression of C-terminally truncated forms of CtIP. We propose that these mutations are the molecular cause of the disease observed in the previously described SCKL2 family and in an additional unrelated family diagnosed with a similar form of congenital microcephaly termed Jawad syndrome. While an exonic frameshift mutation was found in the Jawad family, the SCKL2 family carries a splicing mutation that yields a dominant-negative form of CtIP. Further characterization of cell lines derived from the SCKL2 family revealed defective DNA damage induced formation of single-stranded DNA, a critical co-factor for ATR activation. Accordingly, SCKL2 cells present a lowered apoptopic threshold and hypersensitivity to DNA damage. Notably, over-expression of a comparable truncated CtIP variant in non-Seckel cells recapitulates SCKL2 cellular phenotypes in a dose-dependent manner. This work thus identifies CtIP as a disease gene for Seckel and Jawad syndromes and defines a new type of genetic disease mechanism in which a dominant negative mutation yields a recessively inherited disorder.

  18. Comparative calibration of IP scanning equipment

    Science.gov (United States)

    Ingenito, F.; Andreoli, P.; Batani, D.; Boutoux, G.; Cipriani, M.; Consoli, F.; Cristofari, G.; Curcio, A.; De Angelis, R.; Di Giorgio, G.; Ducret, J.; Forestier-Colleoni, P.; Hulin, S.; Jakubowska, K.; Rabhi, N.

    2016-05-01

    Imaging Plates (IP) are diagnostic devices which contain a photostimulable phosphor layer that stores the incident radiation dose as a latent image. The image is read with a scanner which stimulates the decay of electrons, previously excited by the incident radiation, by exposition to a laser beam. This results in emitted light, which is detected by photomultiplier tubes; so the latent image is reconstructed. IPs have the interesting feature that can be reused many times, after erasing stored information. Algorithms to convert signals stored in the detector to Photostimulated luminescence (PSL) counts depend on the scanner and are not available on every model. A comparative cross-calibration of the IP scanner Dürr CR35 BIO, used in ABC laboratory, was performed, using the Fujifilm FLA 7000 scanner as a reference, to find the equivalence between grey-scale values given by the Dürr scanner to PSL counts. Using an IP and a 55Fe β-source, we produced pairs of samples with the same exposition times, which were analysed by both scanners, placing particular attention to fading times of the image stored on IPs. Data analysis led us to the determine a conversion formula which can be used to compare data of experiments obtained in different laboratories and to use IP calibrations available, till now, only for Fujifilm scanners.

  19. PENGEMBANGAN PERANGKAT PEMBELAJARAN IPS DENGAN PENDEKATAN INQUIRY

    Directory of Open Access Journals (Sweden)

    Lisna Handayani

    2015-08-01

    Full Text Available Tujuan  penelitian adalah menghasilkan perangkat pembelajaran IPS dengan Pendekatan Inquiry. Penelitian pengembangan ini menggunakan langkah-langkah Borg and Gall yang terdiri dari tiga tahapan utama yaitu pendahuluan, pengembangan dan validasi. Data yang diperoleh adalah hasil belajar, aktivitas diskusi dan respon peserta didik. Data dianalisis menggunakan analisis deskriptif dan uji t. Penggunaan pendekatan inquiry sebagai salah satau strategi pembelajaran IPS dapat dilakukan dengan mempersiapkan terlebih dahulu perangkat pembelajarannya. Hasil pengembangan divalidasi oleh pakar, diujicobakan pada kelas terbatas dan selanjutnya dilakukan ujicoba pada kelas eksperimen yang dibandingkan hasilnya dengan kelas kontrol. Perangkat pembelajaran tergolong efektif untuk meningkatkan hasil belajar peserta didik di kelas VII SMP Negeri 2 Jepara, terbukti dari adanya peningkatan yang nyata terbukti dari hasil uji paired sampel t-test dengan nilai signifikansi 0,000 <0,05, dan terjadi peningkatan yang tinggi (gain > 0,7, serta hasil belajar yang dicapai berbeda secara signifikan dengan kelompok kontrol. Di samping hasil belajar, pembelajaran yang dilakukan juga berdampak pada proses belajar yang membawa tingginya aktivitas peserta didik dalam memberikan gagasan, kerjasama, inisiatif, keaktifan dan kedisiplinan. The purpose of this research is creating Social Lesson Material with Inquiry Approach.This developing of the research is used of  the steps of Borg and Gall. They are Introducing, developing and evaluating. Learning materials are developed and validity by expert. Datas are gooten by study result, discussion activity and students, respone. Analizing datas are used descriptive analize and t- try out. The use of inquiry approach as one of learning strategy on Social Lesson Material can be done by preparing those. The result of  developing are being validity by expert,  try out on limited group and experiment group ad compare with control group

  20. Enhanced fluorescence of graphene oxide by well-controlled Au@SiO2 core-shell nanoparticles.

    Science.gov (United States)

    Li, Cuiyan; Zhu, Yihua; Wang, Siwen; Zhang, Xiaoqing; Yang, Xiaoling; Li, Chunzhong

    2014-01-01

    Graphene and graphene derivatives, including graphene oxide (GO) and reduced GO (rGO), have attracted remarkable attention in different fields due to their unique electronic, thermal, and mechanical properties, whereas the fluorescence property is rarely been studied. This paper reports on metal-enhanced fluorescence Au@SiO2 composite nanoparticles adsorbed graphene oxide nanosheets, where the silica-shell is used to control the distance between gold-core and fluorophore GO, and a positively charged polyelectrolyte poly(allylamine hydrochloride) (PAH) is used to adsorb the negatively charged silica-shell and GO by layer-by-layer assembly (LbL) approach. The silica-shell around the 80 nm gold-core can be well-controlled by ending the reaction at different times. Various analytical techniques were applied to characterize the morphology and optical characters of the as-prepared particles. A more than three-fold increase of the fluorescence intensity of GO was obtained.

  1. Effects of hypoxia on pluripotency in murine iPS cells.

    Science.gov (United States)

    Sugimoto, Kouji; Yoshizawa, Yuu; Yamada, Shizuka; Igawa, Kazunari; Hayashi, Yoshihiko; Ishizaki, Hidetaka

    2013-10-01

    Retroviral transduction of four transcription factors (Oct4, Sox2, Klf4 and c-Myc) or three factors, excluding c-Myc, has been shown to initiate a reprogramming process that results in the transformation of murine fibroblasts to induced pluripotent stem (iPS) cells, and there has been a rapid increase in the number of iPS cell-based preclinical trials. In this study, the effects of these transcription factors were evaluated regarding the growth and differentiation of murine iPS cells under hypoxia. Based on the results of RT-PCR and alizarin red S staining, there were no statistical differences in the growth and differentiation of iPS cells or the induction of iPS cells to osteoblasts under hypoxia between the transcription factor groups. Furthermore, the function of hypoxia inducible factors (HIFs) in murine iPS cells under hypoxia was investigated in relation to the morphology and expression of transcription factors using RT-PCR and Western blotting. The HIF-2α knockdown group exhibited a decrease in the colony size of the iPS cells. The HIF-2α or -3α knockdown group demonstrated a statistically significant decrease in the transcription factor expression compared to that observed in the control group. These results demonstrate that HIF-2α among HIFs is the most influential candidate for the maintenance of the pluripotency of murine iPS cells.

  2. Fractional-order system identification and proportional-derivative control of a solid-core magnetic bearing.

    Science.gov (United States)

    Zhong, Jianpeng; Li, Lichuan

    2014-07-01

    This paper presents the application of fractional-order system identification (FOSI) and proportional-derivative (PD(µ)) control to a solid-core magnetic bearing (MB). A practical strategy for closed-loop incommensurate FOSI along with a modified error criterion is utilized to model the MB system and a corresponding, verification experiment is carried out. Based on the identified model, integer-order (IO) PD and fractional-order (FO) PD(µ) controllers are designed and compared with the same specifications. Besides, the relation between the two categories of controllers is discussed by their feasible control zones. Final simulation and experimental results show that the FO PD(µ) controller can significantly improve the transient and steady-state performance of the MB system comparing with the IO PD controller. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  3. Core Cross-linked Star Polymers for Temperature/pH Controlled Delivery of 5-Fluorouracil

    Directory of Open Access Journals (Sweden)

    Elizabeth Sánchez-Bustos

    2016-01-01

    Full Text Available RAFT polymerization with cross-linking was used to prepare core cross-linked star polymers bearing temperature sensitive arms. The arms consisted of a diblock copolymer containing N-isopropylacrylamide (NIPAAm and 4-methacryloyloxy benzoic acid (4MBA in the temperature sensitive block and poly(hexyl acrylate forming the second hydrophobic block, while ethyleneglycol dimethacrylate was used to form the core. The acid comonomer provides pH sensitivity to the arms and also increases the transition temperature of polyNIPAAm to values in the range of 40 to 46°C. Light scattering and atomic force microscopy studies suggest that loose core star polymers were obtained. The star polymers were loaded with 5-fluorouracil (5-FU, an anticancer agent, in values of up to 30 w/w%. In vitro release experiments were performed at different temperatures and pH values, as well as with heating and cooling temperature cycles. Faster drug release was obtained at 42°C or pH 6, compared to normal physiological conditions (37°C, pH 7.4. The drug carriers prepared acted as nanopumps changing the release kinetics of 5-FU when temperatures cycles were applied, in contrast with release rates at a constant temperature. The prepared core cross-linked star polymers represent advanced drug delivery vehicles optimized for 5-FU with potential application in cancer treatment.

  4. Cisco Router Configuration with IP

    Directory of Open Access Journals (Sweden)

    Ashiqur Rahman

    2016-07-01

    Full Text Available A router is a networking device that forwards data packets between computer networks. Routers perform the "traffic directing" functions on the Internet. A data packet is typically forwarded from one router to another through the networks that constitute the internetwork until it reaches its destination node. A router is connected to two or more data lines from different networks (as opposed to a network switch, which connects data lines from one single network. When a data packet comes in on one of the lines, the router reads the address information in the packet to determine its ultimate destination. Then, using information in its routing table or routing policy, it directs the packet to the next network on its journey. This creates an overlay internetwork. The most familiar type of routers are home and small office routers that simply pass data, such as web pages, email, IM, and videos between the home computers and the Internet. An example of a router would be the owner's cable or DSL router, which connects to the Internet through an ISP. More sophisticated routers, such as enterprise routers, connect large business or ISP networks up to the powerful core routers that forward data at high speed along the optical fiber lines of the Internet backbone. Though routers are typically dedicated hardware devices, use of software-based routers has grown increasingly common.

  5. Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial.

    Science.gov (United States)

    Schell-Chaple, Hildy M; Liu, Kathleen D; Matthay, Michael A; Sessler, Daniel I; Puntillo, Kathleen A

    2017-07-01

    To determine the effects of IV acetaminophen on core body temperature, blood pressure, and heart rate in febrile critically ill patients. Randomized, double-blind, placebo-controlled clinical trial. Three adult ICUs at a large, urban, academic medical center. Forty critically ill adults with fever (core temperature, ≥ 38.3°C). An infusion of acetaminophen 1 g or saline placebo over 15 minutes. Core temperature and vital signs were measured at baseline and at 5-15-minute intervals for 4 hours after infusion of study drug. The primary outcome was time-weighted average core temperature adjusted for baseline temperature. Secondary outcomes included adjusted time-weighted average heart rate, blood pressure, and respiratory rate, along with changes-over-time for each. Baseline patient characteristics were similar in those given acetaminophen and placebo. Patients given acetaminophen had an adjusted time-weighted average temperature that was 0.47°C less than those given placebo (95% CI, -0.76 to -0.18; p = 0.002). The acetaminophen group had significantly lower adjusted time-weighted average systolic blood pressure (-17 mm Hg; 95% CI, -25 to -8; p acetaminophen decreased temperature, blood pressure, and heart rate. IV acetaminophen thus produces modest fever reduction in critical care patients, along with clinically important reductions in blood pressure.

  6. Determination of power peak factor using control rods, ex-core detectors and neural networks; Determinacao do fator de pico de potencia utilizando barras de controle, detectores ex-core e redes neurais

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Rose Mary Gomes do Prado

    2005-07-01

    This work presents a methodology based on the artificial neural network technique to predict in real time the power peak factor in a form that can be implemented in reactor protection systems. The neural network inputs were those available in the reactor protection systems, namely, the axial and quadrant power differences obtained from measured ex-core detector signals, and the position of control rods. The response of ex core detector signals was measured in experiments especially performed in the IPEN/MB-01 zero-power reactor. Several reactor states with different power density distribution were obtained by positioning the control rods in different configurations. The power distribution and its peak factor were calculated for each of these reactor states using the Citation code. The obtained results show that the power peak factor correlates well with the control rod position and the quadrant power difference, and with a lesser degree with the axial power differences. The data presented an inherent organisation and could be classified into different classes of power peak factor behaviour as a function of position of control rods, axial power difference and quadrant power difference. The RBF networks were able to identify classes and interpolate the power peak factor values. The relative error for the power peak factor estimation ranged from 0.19 % to 0.67 %, less than the one that was obtained performing a power density distribution map with in-core detectors. It was observed that the positions of control rods bear the detailed and localised information about the power density distribution, and that the axial and the quadrant power difference describe its global variations in the axial and radial directions. The results showed that the RBF and MLP networks produced similar results, and that a neural network correlation can be implemented in power reactor protection systems. (author)

  7. IPS in Europe: the EQOLISE trial.

    Science.gov (United States)

    Burns, Tom; Catty, Jocelyn

    2008-01-01

    IPS has been demonstrated to increase return to open employment significantly in individuals with mental health problems in the US. Previous experience (e.g. with ACT) has demonstrated the sensitivity of complex community mental health interventions to local social and healthcare cultures. Europe has conditions of generally greater employment security than the US and varying (generally higher) unemployment rates and welfare benefits. Evidence of the effectiveness of IPS in these conditions, and its potential variation across them, would guide local policy and provide possible insights into its mechanism. We conducted an RCT of IPS versus high-quality train-and-place vocational rehabilitation in six European centers with very different labor market and health and social care conditions. A sample of 312 individuals with psychotic illness was randomly allocated (50 per site). Inclusion criteria were a minimum of two years' illness duration, with at least one year of continuous unemployment and six months contact with their current mental health services. Follow-up was 18 months. The primary outcome was any open employment, and secondary outcomes included time to employment, duration of employment and hospital admission. IPS was more effective than the Vocational Services for all vocational outcomes. 85 IPS patients (54.5%) worked for at least one day compared to 43 Vocational Service patients (27.6). They were significantly less likely to be rehospitalized. Local unemployment rates explained a significant amount of the variation in IPS effectiveness and both national economic growth and welfare systems influenced overall employment rates in both services. IPS doubles the access to work of people with psychotic illnesses, without any evidence of increased relapse. Its effectiveness is not independent of external circumstances, particularly local unemployment rates.

  8. The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates.

    Science.gov (United States)

    Jones, Grant D; Williams, Ernest P; Place, Allen R; Jagus, Rosemary; Bachvaroff, Tsvetan R

    2015-02-10

    Dinoflagellates are eukaryotes with unusual cell biology and appear to rely on translational rather than transcriptional control of gene expression. The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in regulating gene expression because eIF4E binding to the mRNA cap is a control point for translation. eIF4E is part of an extended, eukaryote-specific family with different members having specific functions, based on studies of model organisms. Dinoflagellate eIF4E diversity could provide a mechanism for dinoflagellates to regulate gene expression in a post-transcriptional manner. Accordingly, eIF4E family members from eleven core dinoflagellate transcriptomes were surveyed to determine the diversity and phylogeny of the eIF4E family in dinoflagellates and related lineages including apicomplexans, ciliates and heterokonts. The survey uncovered eight to fifteen (on average eleven) different eIF4E family members in each core dinoflagellate species. The eIF4E family members from heterokonts and dinoflagellates segregated into three clades, suggesting at least three eIF4E cognates were present in their common ancestor. However, these three clades are distinct from the three previously described eIF4E classes, reflecting diverse approaches to a central eukaryotic function. Heterokonts contain four clades, ciliates two and apicomplexans only a single recognizable eIF4E clade. In the core dinoflagellates, the three clades were further divided into nine sub-clades based on the phylogenetic analysis and species representation. Six of the sub-clades included at least one member from all eleven core dinoflagellate species, suggesting duplication in their shared ancestor. Conservation within sub-clades varied, suggesting different selection pressures. Phylogenetic analysis of eIF4E in core dinoflagellates revealed complex layering of duplication and conservation when compared to other eukaryotes. Our results suggest that the diverse eIF4E family in

  9. DESIGN AND CONTROL OF SOAP-FREE HYDROPHILIC-HYDROPHOBIC CORE-SHELL LATEX PARTICLES WITH HIGH CARBOXYL CONTENT IN THE CORE OF THE PARTICLES

    Institute of Scientific and Technical Information of China (English)

    Wen-jiao Ji; Yi-ming Jiang; Bo-tian Li; Wei Deng; Cheng-you Kan

    2012-01-01

    Soap-free hydrophilic-hydrophobic core-shell latex particles with high carboxyl content in the core of the particles were synthesized via the seeded emulsion polymerization using methyl methacrylate (MMA),butyl acrylate (BA),methacrylic acid (MAA),styrene (St) and ethylene glycol dimethacrylate (EGDMA) as monomers,and the influences of MMA content used in the core preparation on polymerization,particle size and morphology were investigated by transmission electron microscopy,dynamic light scattering and conductometric titration.The results showed that the seeded emulsion polymerization could be carried out smoothly using "starved monomer feeding process" when MAA content in the core preparation was equal to or less than 24 wt%,and the encapsulating efficiency of the hydrophilic P(MMA-BA-MAA-EGDMA) core with the hydrophobic PSt shell decreased with the increase in MAA content.When an interlayer of P(MMA-MAA-St) with moderate polarity was inserted between the P(MMA-BA-MAA-EGDMA) core and the PSt shell,well designed soap-free hydrophilic-hydrophobic core-shell latex particles with 24 wt% MAA content in the core preparation were obtained.

  10. Core y sistema de control neuro-motor: mecanismos básicos para la estabilidad del raquis lumbar

    OpenAIRE

    Víctor SEGARRA; HEREDIA,Juan Ramón; Peña, Guillermo; SAMPIETRO,Matías; MOYANO,Mauricio; Fernando MATA; ISIDRO,Felipe; Martín, Fernando; Da Silva-Grigoletto, Marzo Edir

    2014-01-01

    El "CORE" es un concepto funcional que engloba la integración de tres sistemas cuyo óptimo funcionamiento garantiza la realización de tareas con una mayor eficacia y seguridad a nivel raquídeo, permitiendo adecuados niveles de estabilidad y control del movimiento. En este sentido, a fin de afrontar con éxito retos que demanden un control dinámico de la columna y la pelvis, el SNC debe aplicar estrategias diferentes, sopesando as fuerzas internas y externas con el fin de proporcionar una respu...

  11. The differential characteristics of control rods of VVER-1000 core simulator at a low number of axial mesh points

    Science.gov (United States)

    Bolsunov, A. A.; Karpov, S. A.

    2013-12-01

    An algorithm for refining the differential characteristics of the control rods (CRs) of the control and protection system (CPS) for a neutronics model of the VVER-1000 simulator at a low number of axial mesh points of the core is described. The problem of determining the constants for a cell with a partially inserted CR is solved. The cell constants obtained using the proposed approach ensure smoothing of the differential characteristics of an absorbing rod. The algorithm was used in the VVER-1000 simulators (Bushehr NPP, unit no. 1; Rostov NPP, unit no. 1; and Balakovo NPP, unit no. 4).

  12. Core y sistema de control neuro-motor: mecanismos básicos para la estabilidad del raquis lumbar

    OpenAIRE

    SEGARRA,Víctor; Juan Ramón HEREDIA; PEÑA,Guillermo; SAMPIETRO,Matías; MOYANO,Mauricio; Mata, Fernando; ISIDRO,Felipe; Martín, Fernando; Da Silva-Grigoletto, Marzo Edir

    2014-01-01

    El "CORE" es un concepto funcional que engloba la integración de tres sistemas cuyo óptimo funcionamiento garantiza la realización de tareas con una mayor eficacia y seguridad a nivel raquídeo, permitiendo adecuados niveles de estabilidad y control del movimiento. En este sentido, a fin de afrontar con éxito retos que demanden un control dinámico de la columna y la pelvis, el SNC debe aplicar estrategias diferentes, sopesando as fuerzas internas y externas con el fin de proporcionar una respu...

  13. A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis

    DEFF Research Database (Denmark)

    Ruhwald, Morten; Dominguez, Jose; Latorre, Irene;

    2011-01-01

    cases with active TB, 101 healthy controls and 175 non-TB patients were included. IP-10 and IFN-γ were measured in plasma of QFT-IT stimulated whole blood and analyzed using previously determined algorithms. A subgroup of 48 patients and 70 healthy controls was tested in parallel with T-SPOT.TB IP-10...

  14. Research of real-time wavefront reconstruction and control based on multi-core DSP

    Science.gov (United States)

    Wang, Zhui; Zhou, Luchun; Li, Mei; Zhang, Haotian

    2014-09-01

    In an Adaptive Optics system, the Real Time Processor is as important as the human brain. Processing latency is a key index of Real Time Proceesors . In this paper, we propose a new processing method that significantly reduce the processing latency, which combined the design idea of multi-core parallel processing on space and time. In addition, by comparing the operating speed of CPU and the I/O speed of memory, we propose a reasonable memory allocation scheme. The experimental results show that the processing latency is 59.7us per frame using multi-core DSP TMS320C6678 as processing platform. The experiment is conducted on a system with 968 sub-apertures and 913 actuators.

  15. Voltage controlled core reversal of fixed magnetic skyrmions without a magnetic field

    Science.gov (United States)

    Bhattacharya, Dhritiman; Al-Rashid, Md Mamun; Atulasimha, Jayasimha

    2016-08-01

    Using micromagnetic simulations we demonstrate core reversal of a fixed magnetic skyrmion by modulating the perpendicular magnetic anisotropy of a nanomagnet with an electric field. We can switch reversibly between two skyrmion states and two ferromagnetic states, i.e. skyrmion states with the magnetization of the core pointing down/up and periphery pointing up/down, and ferromagnetic states with magnetization pointing up/down, by sequential increase and decrease of the perpendicular magnetic anisotropy. The switching between these states is explained by the fact that the spin texture corresponding to each of these stable states minimizes the sum of the magnetic anisotropy, demagnetization, Dzyaloshinskii-Moriya interaction (DMI) and exchange energies. This could lead to the possibility of energy efficient nanomagnetic memory and logic devices implemented with fixed skyrmions without using a magnetic field and without moving skyrmions with a current.

  16. Core Power Control of the fast nuclear reactors with estimation of the delayed neutron precursor density using Sliding Mode method

    Energy Technology Data Exchange (ETDEWEB)

    Ansarifar, G.R., E-mail: ghr.ansarifar@ast.ui.ac.ir; Nasrabadi, M.N.; Hassanvand, R.

    2016-01-15

    Highlights: • We present a S.M.C. system based on the S.M.O for control of a fast reactor power. • A S.M.O has been developed to estimate the density of delayed neutron precursor. • The stability analysis has been given by means Lyapunov approach. • The control system is guaranteed to be stable within a large range. • The comparison between S.M.C. and the conventional PID controller has been done. - Abstract: In this paper, a nonlinear controller using sliding mode method which is a robust nonlinear controller is designed to control a fast nuclear reactor. The reactor core is simulated based on the point kinetics equations and one delayed neutron group. Considering the limitations of the delayed neutron precursor density measurement, a sliding mode observer is designed to estimate it and finally a sliding mode control based on the sliding mode observer is presented. The stability analysis is given by means Lyapunov approach, thus the control system is guaranteed to be stable within a large range. Sliding Mode Control (SMC) is one of the robust and nonlinear methods which have several advantages such as robustness against matched external disturbances and parameter uncertainties. The employed method is easy to implement in practical applications and moreover, the sliding mode control exhibits the desired dynamic properties during the entire output-tracking process independent of perturbations. Simulation results are presented to demonstrate the effectiveness of the proposed controller in terms of performance, robustness and stability.

  17. METODOLOGÍA DE CONTROL DE MÁQUINAS ELÉCTRICAS DE IP CON CAPACIDAD DE DEBILITAMIENTO DE CAMPO CONTROL METHODOLOGY OF PM MACHINE WITH FIELD WEAKENING CAPABILITY

    Directory of Open Access Journals (Sweden)

    Delvis González L

    2007-04-01

    Full Text Available En el mundo actual los requerimientos de los accionamientos se hacen cada vez más exigentes en cuanto a precisión y eficiencia. Por esta razón los diseñadores se ven obligados a encontrar nuevas topologías y mecanismos de control que las satisfagan, especialmente para aplicaciones de velocidad variable como tracción eléctrica. Las máquinas sincrónicas de imanes permanentes son una solución atractiva debido a su elevada eficiencia y su gran densidad de potencia. En estas aplicaciones, para velocidad por debajo de la nominal, el accionamiento opera a torque constante siguiendo la trayectoria de máximo par por ampere. Para valores de velocidad por encima de la nominal es necesario inyectar un flujo negativo en el eje directo, para reducir el flujo impuesto por el imán. De esta manera el voltaje y la corriente se mantienen en 1.0 pu. Este efecto se logra con un control adecuado del ángulo de la corriente en los ejes dq. Este trabajo muestra un método de control para operar las máquinas de corriente alterna e imanes permanentes con capacidad de debilitamiento de campo. Utilizando el Simulink del Matlab se verifica la estrategia de control propuesta. Además se muestran las propiedades de una nueva topología de MCAIP para aplicaciones de velocidad variable.Presently the AC machine drive’s requirements are more demanding in terms of precision and efficiency. Under these circumstances, designers are forced to find new machine topologies and control methods to meet these conditions, especially for variable speed applications such us electric traction. PM machines are an attractive solution because of their intrinsic higher efficiency and their power density. For these operations - below the rated speed - the drive works under constant torque strategy following the maximum torque per ampere trajectory. For speeds over the rated value, it is necessary to inject a negative d-axis flux, to reduce the field imposed by the PM. In this manner

  18. Dab2ip regulates neuronal migration and neurite outgrowth in the developing neocortex.

    Directory of Open Access Journals (Sweden)

    Gum Hwa Lee

    Full Text Available Dab2ip (DOC-2/DAB2 interacting protein is a member of the Ras GTPase-activating protein (GAP family that has been previously shown to function as a tumor suppressor in several systems. Dab2ip is also highly expressed in the brain where it interacts with Dab1, a key mediator of the Reelin pathway that controls several aspects of brain development and function. We found that Dab2ip is highly expressed in the developing cerebral cortex, but that mutations in the Reelin signaling pathway do not affect its expression. To determine whether Dab2ip plays a role in brain development, we knocked down or over expressed it in neuronal progenitor cells of the embryonic mouse neocortex using in utero electroporation. Dab2ip down-regulation severely disrupts neuronal migration, affecting preferentially late-born principal cortical neurons. Dab2ip overexpression also leads to migration defects. Structure-function experiments in vivo further show that both PH and GRD domains of Dab2ip are important for neuronal migration. A detailed analysis of transfected neurons reveals that Dab2ip down- or up-regulation disrupts the transition from a multipolar to a bipolar neuronal morphology in the intermediate zone. Knock down of Dab2ip in neurons ex-vivo indicates that this protein is necessary for proper neurite development and for the expression of several major neuronal microtubule associated proteins (MAPs, which are important for neurite growth and stabilization. Thus, our study identifies, for the first time, a critical role for Dab2ip in mammalian cortical development and begins to reveal molecular mechanisms that underlie this function.

  19. Synthesis of Magnetic Rattle-Type Silica with Controllable Magnetite and Tunable Size by Pre-Shell-Post-Core Method.

    Science.gov (United States)

    Chen, Xue; Tan, Longfei; Meng, Xianwei

    2016-03-01

    In this study, we have developed the pre-shell-post-core route to synthesize the magnetic rattle-type silica. This method has not only simplified the precursor's process and reduced the reacting time, but also ameliorated the loss of magnetite and made the magnetite content and the inner core size controllable and tunable. The magnetite contents and inner core size can be easily controlled by changing the type and concentration of alkali, reaction system and addition of water. The results show that alkali aqueous solution promotes the escape of the precursor iron ions from the inner space of rattle-type silica and results in the loss of magnetite. In this case, NaOH ethanol solution is better for the formation of magnetite than ammonia because it not only offers an appropriate alkalinity to facilitate the synthesis of. magnetic particles, but also avoids the escape of the iron ions from the mesopores of rattle-type silica. The synthesis process is very simple and efficient, and it takes no more than 2 hours to complete the total preparation and handling of the magnetic rattle-type silica. The end-product Fe3O4@SiO2 nanocomposites also have good magnetic properties which will perform potential application in biomedical science.

  20. Single axis controlled hybrid magnetic bearing for left ventricular assist device: hybrid core and closed magnetic circuit.

    Science.gov (United States)

    da Silva, Isaias; Horikawa, Oswaldo; Cardoso, Jose R; Camargo, Fernando A; Andrade, Aron J P; Bock, Eduardo G P

    2011-05-01

    In previous studies, we presented main strategies for suspending the rotor of a mixed-flow type (centrifugal and axial) ventricular assist device (VAD), originally presented by the Institute Dante Pazzanese of Cardiology (IDPC), Brazil. Magnetic suspension is achieved by the use of a magnetic bearing architecture in which the active control is executed in only one degree of freedom, in the axial direction of the rotor. Remaining degrees of freedom, excepting the rotation, are restricted only by the attraction force between pairs of permanent magnets. This study is part of a joint project in development by IDPC and Escola Politecnica of São Paulo University, Brazil. This article shows advances in that project, presenting two promising solutions for magnetic bearings. One solution uses hybrid cores as electromagnetic actuators, that is, cores that combine iron and permanent magnets. The other solution uses actuators, also of hybrid type, but with the magnetic circuit closed by an iron core. After preliminary analysis, a pump prototype has been developed for each solution and has been tested. For each prototype, a brushless DC motor has been developed as the rotor driver. Each solution was evaluated by in vitro experiments and guidelines are extracted for future improvements. Tests have shown good results and demonstrated that one solution is not isolated from the other. One complements the other for the development of a single-axis-controlled, hybrid-type magnetic bearing for a mixed-flow type VAD.

  1. Controllable synthesis, characterization and optical properties of colloidal PbS/gelatin core-shell nanocrystals.

    Science.gov (United States)

    Mozafari, Masoud; Moztarzadeh, Fathollah

    2010-11-15

    Native quantum dots (QDs) made up of semiconductor nanocrystals (NCs) are toxic in nature but due to their excellent optical properties, they have proven themselves to be an attractive choice in biological labeling and targeting. In order to improve the general biocompatibility of lead sulfide (PbS) NCs, we present a new and simple procedure for preparing PbS/gelatin core-shell nanoparticles cross-linked with glutaraldehyde (GA) molecules. The phase composition, morphology, luminescence and in vitro photostability of the samples were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR), transmission electron microscope (TEM) and fluorescence spectroscopy, respectively. The XRD analysis showed that the PbS NCs were of the cubic structure, the mean crystallite size was calculated to be 13.5 nm and the calculated lattice constant using Bragg's equation was 0.5950 nm, which was very close to its value in the standard card (JCPDS No. 5-592). In vitro test revealed that compared with bare PbS NCs, the photostability of the core-shell nanostructure remarkably improved. In addition, possible formation mechanisms of the PbS/gelatin nanoparticles were discussed in detail. Consequently, the advantages of high stability as well as high fluorescent intensity and biocompatibility make the core-shell nanoparticles promising candidates for in vivo biological targeting applications.

  2. Bottom-up control of geomagnetic secular variation by the Earth's inner core

    DEFF Research Database (Denmark)

    Aubert, Julien; Finlay, Chris; Fournier, Alexandre

    2013-01-01

    Temporal changes in the Earth’s magnetic field, known as geomagnetic secular variation, occur most prominently at low latitudes in the Atlantic hemisphere1, 2 (that is, from −90 degrees east to 90 degrees east), whereas in the Pacific hemisphere there is comparatively little activity. This is a c......Temporal changes in the Earth’s magnetic field, known as geomagnetic secular variation, occur most prominently at low latitudes in the Atlantic hemisphere1, 2 (that is, from −90 degrees east to 90 degrees east), whereas in the Pacific hemisphere there is comparatively little activity....... This is a consequence of the geographical localization of intense, westward drifting, equatorial magnetic flux patches at the core surface3. Despite successes in explaining the morphology of the geomagnetic field4, numerical models of the geodynamo have so far failed to account systematically for this striking pattern......-like gyre6. The resulting shear concentrates azimuthal magnetic flux at low latitudes close to the core–mantle boundary, where it is expelled by core convection and subsequently transported westward. Second, differential inner-core growth7, 8, fastest below Indonesia6, 9, causes an asymmetric buoyancy...

  3. Effects of core strength training using stable versus unstable surfaces on physical fitness in adolescents: a randomized controlled trial.

    Science.gov (United States)

    Granacher, Urs; Schellbach, Jörg; Klein, Katja; Prieske, Olaf; Baeyens, Jean-Pierre; Muehlbauer, Thomas

    2014-01-01

    It has been demonstrated that core strength training is an effective means to enhance trunk muscle strength (TMS) and proxies of physical fitness in youth. Of note, cross-sectional studies revealed that the inclusion of unstable elements in core strengthening exercises produced increases in trunk muscle activity and thus provide potential extra training stimuli for performance enhancement. Thus, utilizing unstable surfaces during core strength training may even produce larger performance gains. However, the effects of core strength training using unstable surfaces are unresolved in youth. This randomized controlled study specifically investigated the effects of core strength training performed on stable surfaces (CSTS) compared to unstable surfaces (CSTU) on physical fitness in school-aged children. Twenty-seven (14 girls, 13 boys) healthy subjects (mean age: 14 ± 1 years, age range: 13-15 years) were randomly assigned to a CSTS (n = 13) or a CSTU (n = 14) group. Both training programs lasted 6 weeks (2 sessions/week) and included frontal, dorsal, and lateral core exercises. During CSTU, these exercises were conducted on unstable surfaces (e.g., TOGU© DYNAIR CUSSIONS, THERA-BAND© STABILITY TRAINER). Significant main effects of Time (pre vs. post) were observed for the TMS tests (8-22%, f = 0.47-0.76), the jumping sideways test (4-5%, f = 1.07), and the Y balance test (2-3%, f = 0.46-0.49). Trends towards significance were found for the standing long jump test (1-3%, f = 0.39) and the stand-and-reach test (0-2%, f = 0.39). We could not detect any significant main effects of Group. Significant Time x Group interactions were detected for the stand-and-reach test in favour of the CSTU group (2%, f = 0.54). Core strength training resulted in significant increases in proxies of physical fitness in adolescents. However, CSTU as compared to CSTS had only limited additional effects (i.e., stand-and-reach test). Consequently, if the

  4. Is IP-10 a better biomarker for active and latent tuberculosis in children than IFNgamma?

    Directory of Open Access Journals (Sweden)

    Elizabeth Whittaker

    Full Text Available BACKGROUND: The blood based interferon-gamma release assays (IGRA for the diagnosis of tuberculosis do not discriminate between active TB disease and latent TB infection (LTBI. The search for distinguishing biomarkers therefore continues, as the accurate diagnosis of tuberculosis is particularly challenging in children. IFN-gamma-inducible protein 10 (IP-10/CXCL10 has recently been evaluated as a marker for active TB in adults with promising results. AIM: To investigate this new biomarker for active TB and LTBI in paediatrics. METHOD: We measured IP-10 levels using ELISA in supernatants of whole blood samples stimulated with TB-specific-antigens and negative control antigen. RESULTS: IP-10 is produced in high levels following mycobacterial antigen stimulation in active TB (n = 17 and LTBI (n = 16 compared to controls (n = 16 and to IFN-gamma. The baseline levels of IP-10 are increased in active TB and in LTBI, but there is no significant difference of stimulated levels of IP-10 between active TB and LTBI. CONCLUSIONS: IP-10 is a biomarker for tuberculosis in children. However like IFNgamma, IP-10 also does not distinguish between active TB and LTBI.

  5. Measurement of the nonmagnetic coating thickness of core-shell magnetic nanoparticles by controlled magnetization magnetic force microscopy

    Science.gov (United States)

    Angeloni, L.; Passeri, D.; Scaramuzzo, F. A.; Di Iorio, D.; Barteri, M.; Mantovani, D.; Rossi, M.

    2016-06-01

    Magnetic nanoparticles (MNPs) represent an interesting tool for several biomedical applications. In order to improve the dispersion stability, the biocompatibility and bio-functionality, MNPs need to be coated with non-magnetic films. The optimization of these systems requires the deep characterization not only of the magnetic core, but also of the coating features. Beside the chemical and physical properties of the coating, its thickness is another important property which can influence the size, the shape and the overall magnetic behavior of the NPs system. In this work we propose a possible method to measure the thickness of the non-magnetic coating of core-shell MNPs through the use of controlled magnetization-magnetic force microscopy (CM-MFM). A preliminary study on the applicability of the proposed method has been performed on Fe3O4 NPs coated with a Cu film.

  6. Fatigue characterization of Poly Vinyl Chloride (PVC) foam core sandwich composite using the G-control method

    DEFF Research Database (Denmark)

    Manca, Marcello; Berggreen, Christian; Carlsson, Leif A.

    2016-01-01

    This paper presents experimental results from cyclic crack propagation tests performed on sandwich specimens with glass/epoxy face sheets and Poly Vinyl Chloride (PVC) foam cores using the G-controlled cyclic energy release rate (ΔG) test procedure. The face material was tested in tension......, compression and shear to determine in-plane and out-of-plane mechanical properties, such as Young’s modulus, Poisson’s ratio and shear modulus. These properties were then used in an analytical model of the mixed-mode bending sandwich specimen to calculate compliance and energy release rate. Finite element...... analysis was used to determine the mode-mixity of the crack loading. Experimental crack growth cyclic tests were carried out on pre-cracked mixed-mode bending sandwich specimens with H45, H100 and H160 PVC foam cores under two mode-mixities (mode I and mode II dominant). Post-mortem analysis was performed...

  7. Benchmark of Atucha-2 PHWR RELAP5-3D control rod model by Monte Carlo MCNP5 core calculation

    Energy Technology Data Exchange (ETDEWEB)

    Pecchia, M.; D' Auria, F. [San Piero A Grado Nuclear Research Group GRNSPG, Univ. of Pisa, via Diotisalvi, 2, 56122 - Pisa (Italy); Mazzantini, O. [Nucleo-electrica Argentina Societad Anonima NA-SA, Buenos Aires (Argentina)

    2012-07-01

    Atucha-2 is a Siemens-designed PHWR reactor under construction in the Republic of Argentina. Its geometrical complexity and peculiarities require the adoption of advanced Monte Carlo codes for performing realistic neutronic simulations. Therefore core models of Atucha-2 PHWR were developed using MCNP5. In this work a methodology was set up to collect the flux in the hexagonal mesh by which the Atucha-2 core is represented. The scope of this activity is to evaluate the effect of obliquely inserted control rod on neutron flux in order to validate the RELAP5-3D{sup C}/NESTLE three dimensional neutron kinetic coupled thermal-hydraulic model, applied by GRNSPG/UNIPI for performing selected transients of Chapter 15 FSAR of Atucha-2. (authors)

  8. Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis

    DEFF Research Database (Denmark)

    Blauenfeldt, Thomas; Wagner, Dirk; Aabye, Martine Grosos;

    2016-01-01

    INTRODUCTION: Interferon-γ (IFN-γ) inducible protein 10kD (IP-10) and IFN-γ release assays (IGRAs) are immunodiagnostic tests aiming to identify the presence of specific cellular immune responses, interpreted as markers for latent infection with Mycobacterium tuberculosis. Incubation at higher...... accuracy of IP-10 release assay and IGRAs. RESULTS: We included 65 patients with confirmed pulmonary tuberculosis and 160 healthy controls from 6 European centres collaborating in the TBnet. In patients, IP-10 responses increased 1.07 (IQR 0.90-1.36) fold and IFN-γ responses decreased 0.88 (IQR 0...

  9. How to Do a Better IP Commercialization in China?

    Institute of Scientific and Technical Information of China (English)

    WU Ming

    2011-01-01

    1. Status of IP commercialization in China A sound social ecosystem for IP (intellectual property) commercialization will not be established in China overnight because the training of IP professionals and the introducing of IP into management are both a process that takes time.

  10. Simulink based VoIP Analysis

    CERN Document Server

    Singh, Hardeep; Mian, M

    2010-01-01

    Voice communication over internet not be possible without a reliable data network, this was first available when distributed network topologies were used in conjunction with data packets. Early network used single centre node network in which a single workstation (Server) is responsible for the communication. This posed problems as if there was a fault with the centre node, (workstation) nothing would work. This problem was solved by the distributed system in which reliability increases by spreading the load between many nodes. The idea of packet switching & distributed network were combined, this combination were increased reliability, speed & responsible for voice communication over internet, Voice-over-IP (VoIP)These data packets travel through a packet-switched network such as the Internet and arrive at their destination where they are decompressed using a compatible Codec (audio coder/decoder) and converted back to analogue audio. This paper deals with the Simulink architecture for VoIP network.

  11. PARP1 genomics: chromatin immunoprecipitation approach using anti-PARP1 antibody (ChIP and ChIP-seq).

    Science.gov (United States)

    Lodhi, Niraj; Tulin, Alexei V

    2011-01-01

    Poly(ADP-ribose) polymerase1 (PARP1) is a global regulator of different cellular mechanisms, ranging from DNA damage repair to control of gene expression. Since PARP1 protein and pADPr have been shown to persist in chromatin through cell cycle, they may both act as epigenetic markers. However, it is not known how many loci are occupied by PARP1 protein during mitosis genome-wide. To reveal the genome-wide PARP1 binding sites, we used the ChIP-seq approach, an emerging technique to study genome-wide PARP1 protein interaction with chromatin. Here, we describe how to perform ChIP-seq in the context of PARP1 binding sites identification in chromatin, using human embryonic kidney cell lines.

  12. How to Do a Better IP Commercialization in China?

    Institute of Scientific and Technical Information of China (English)

    WU Ming

    2011-01-01

    @@ 1.Status of IP commercialization in China A sound social ecosystem for IP (intellectual property) commercialization will not be established in China overnight because the training of IP professionals and the introducing of IP into management are both a process that takes time. In recent years, the CAS has conducted a series of training programs concerning IP management and service as well as IP team building.Over the past three years, more than 70 senior staffs from CAS institutes have received certificates of IP Specialists from the CAS headquarters after successfully completing a training program.

  13. Control of Electron Beam Using Strong Magnetic Field for Efficient Core Heating in Fast Ignition

    CERN Document Server

    Johzaki, T; Sentoku, Y; Sunahara, A; Nagatomo, H; Sakagami, H; Mima, K; Fujioka, S; Shiraga, H

    2014-01-01

    For enhancing the core heating efficiency in electron-driven fast ignition, we proposed the fast electron beam guiding using externally applied longitudinal magnetic fields. Based on the PIC simulations for the FIREX-class experiments, we demonstrated the sufficient beam guiding performance in the collisional dense plasma by kT-class external magnetic fields for the case with moderate mirror ratio (~<10 ). Boring of the mirror field was found through the formation of magnetic pipe structure due to the resistive effects, which indicates a possibility of beam guiding in high mirror field for higher laser intensity and/or longer pulse duration.

  14. Core Community Specifications for Electron Microprobe Operating Systems: Software, Quality Control, and Data Management Issues

    Science.gov (United States)

    Fournelle, John; Carpenter, Paul

    2006-01-01

    Modem electron microprobe systems have become increasingly sophisticated. These systems utilize either UNIX or PC computer systems for measurement, automation, and data reduction. These systems have undergone major improvements in processing, storage, display, and communications, due to increased capabilities of hardware and software. Instrument specifications are typically utilized at the time of purchase and concentrate on hardware performance. The microanalysis community includes analysts, researchers, software developers, and manufacturers, who could benefit from exchange of ideas and the ultimate development of core community specifications (CCS) for hardware and software components of microprobe instrumentation and operating systems.

  15. Encapsulado de servicios IP sobre redes DVB

    OpenAIRE

    Chamero Hortelano, Adrián

    2006-01-01

    La evolución de los servicios IP hacia las aplicaciones de transporte de contenidos en modo de difusión es un campo de explotación e investigación muy activo. Por otro lado, la convergencia de las diferentes redes de transmisión de datos para soportar dichos servicios provenientes de redes IP es un hecho constatable en muchos ejemplos actualmente de los que las redes DVB, inicialmente concebidas para la dfusión de contenidos audiovisuales, forman parte. Las características ofrecidas ...

  16. Secure IP mobility management for VANET

    CERN Document Server

    Taha, Sanaa

    2013-01-01

    This brief presents the challenges and solutions for VANETs' security and privacy problems occurring in mobility management protocols including Mobile IPv6 (MIPv6), Proxy MIPv6 (PMIPv6), and Network Mobility (NEMO). The authors give an overview of the concept of the vehicular IP-address configurations as the prerequisite step to achieve mobility management for VANETs, and review the current security and privacy schemes applied in the three mobility management protocols. Throughout the brief, the authors propose new schemes and protocols to increase the security of IP addresses within VANETs in

  17. Space-Based Voice over IP Networks

    Science.gov (United States)

    Nguyen, Sam P.; Okino, Clayton; Walsh, William; Clare, Loren

    2007-01-01

    In human space exploration missions (e.g. a return to the Moon and for future missions to Mars), there will be a need to provide voice communications services. In this work we focus on the performance of Voice over IP (VoIP) techniques applied to space networks, where long range latencies, simplex links, and significant bit error rates occur. Link layer and network layer overhead issues are examined. Finally, we provide some discussion on issues related to voice conferencing in the space network environment.

  18. Self-affirmation and self-control: affirming core values counteracts ego depletion.

    Science.gov (United States)

    Schmeichel, Brandon J; Vohs, Kathleen

    2009-04-01

    Research has established that acts of self-control deplete a resource required for subsequent self-control tasks. The present investigation revealed that a psychological intervention-self-affirmation-facilitates self-control when the resource has been depleted. Experiments 1 and 2 found beneficial effects of self-affirmation on self-control in a depleted state. Experiments 3 and 4 suggested that self-affirmation improves self-control by promoting higher levels (vs. lower levels) of mental construal. Self-affirmation therefore holds promise as a mental strategy that reduces the likelihood of self-control failure. (c) 2009 APA, all rights reserved.

  19. Analysis list: Terf2ip [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Terf2ip Embryonic fibroblast + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Terf...2ip.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Terf2ip.5.tsv http://dbarchive.bio...sciencedbc.jp/kyushu-u/mm9/target/Terf2ip.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Terf2ip

  20. Deployment of VoIP Technology: QoS Concerns

    OpenAIRE

    Lazzez, Amor; Slimani, Thabet

    2013-01-01

    Voice over IP (VoIP) is an emerging communication service allowing voice transmission over a private or a public IP network. VoIP allows significant benefits for customers and service providers including cost savings, phone and service portability, mobility, and the integration with other applications. Nevertheless, the deployment of the VoIP technology encounters many challenges such as interoperability issues, security issues, and QoS concerns. Among these disadvantages, QoS issues are cons...

  1. 77 FR 33227 - Assessment Questionnaire-IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT)

    Science.gov (United States)

    2012-06-05

    ... SECURITY Assessment Questionnaire--IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT) AGENCY...--Assessment Questionnaire--IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT). DHS previously...-operators and/or security managers often volunteer to conduct an automated self risk assessment....

  2. 76 FR 81955 - Assessment Questionnaire-IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT)

    Science.gov (United States)

    2011-12-29

    ... SECURITY Assessment Questionnaire--IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT) AGENCY... managers often volunteer to conduct an automated self risk assessment. The requested questionnaire...: Assessment Questionnaire--IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT). OMB Number:...

  3. Scaling Denitrification Fluxes from Cores to Catchments: Spatial and Temporal Controls

    Science.gov (United States)

    Duncan, J. M.; Band, L. E.; Groffman, P. M.

    2015-12-01

    The influence of spatial and temporal heterogeneity on nitrogen cycling can be profound but catchment scale understanding remains elusive. One of the largest sources of uncertainty is the importance of denitrification. Determining in situ rates of denitrification in elements of landscape that remove a disproportionately high amount of N from certain areas of catchment (hot spots) in response to seasonal and event driven conditions (hot moments) is critical to closing watershed nitrogen budgets. We develop an approach to scale denitrification flux from seasonal soil cores collected in different landscape positions to the entire watershed using a combination of laboratory core experiments, terrain analysis and in situ soil oxygen and soil moisture content sensors. In the Pond Branch watershed in the Piedmont region of Maryland, nitrogen deposition values are relatively high (9kg/ha/yr) with low stream export (0.5 kg/ha/yr). Our data suggest that at least 16-27% of this retention can be accounted for by denitrification in certain areas of the riparian zone. We highlight the importance of riparian microtopography and the need to better link observations and models.

  4. Using rolling to develop neuromuscular control and coordination of the core and extremities of athletes.

    Science.gov (United States)

    Hoogenboom, Barbara J; Voight, Michael L; Cook, Gray; Gill, Lance

    2009-05-01

    Rolling is a movement pattern seldom used by physical therapists for assessment and intervention with adult clientele with normal neurologic function. Rolling, as an adult motor skill, combines the use of the upper extremities, core, and lower extremities in a coordinated manner to move from one posture to another. Rolling is accomplished from prone to supine and supine to prone, although the method by which it is performed varies among adults. Assessment of rolling for both the ability to complete the task and bilateral symmetry may be beneficial for use with athletes who perform rotationally-biased sports such as golf, throwing, tennis, and twisting sports such as dance, gymnastics, and figure skating. Additionally, when used as intervention techniques, the rolling patterns have the ability to affect dysfunction of the upper quarter, core, and lower quarter. By applying proprioceptive neuromuscular facilitation (PNF) principles, the therapist may assist patients and clients who are unable to complete a rolling pattern. Examples given in the article include distraction/elongation, compression, and manual contacts to facilitate proper rolling. The combined experience of the four authors is used to describe techniques for testing, assessment, and treatment of dysfunction, using case examples that incorporate rolling. The authors assert that therapeutic use of the developmental pattern of rolling with techniques derived from PNF is a hallmark in rehabilitation of patients with neurologic dysfunction, but can be creatively and effectively utilized in musculoskeletal rehabilitation.

  5. MOVPE growth of position-controlled InGaN / GaN core-shell nanorods

    Energy Technology Data Exchange (ETDEWEB)

    Mandl, Martin [Osram Opto Semiconductors GmbH, Regensburg (Germany); Institut fuer Halbleitertechnik, TU Braunschweig (Germany); Schimpke, Tilman; Binder, Michael; Galler, Bastian; Lugauer, Hans-Juergen; Strassburg, Martin [Osram Opto Semiconductors GmbH, Regensburg (Germany); Wang, Xue; Ledig, Johannes; Ehrenburg, Milena; Wehmann, Hergo-Heinrich; Waag, Andreas [Institut fuer Halbleitertechnik, TU Braunschweig (Germany); Kong, Xiang; Trampert, Achim [Paul-Drude-Institut fuer Festkoerperelektronik, Berlin (Germany)

    2013-07-01

    Core-shell group III-nitride nano- and microrods (NAMs) enable a significant increase of the active layer area by exploiting the non-polar side facets (m-planes) and thus can potentially contribute to mitigating the so-called efficiency droop in LEDs. GaN NAMs exhibiting high aspect ratios were grown in a production-type MOVPE system. Low V/III ratio, hydrogen-rich carrier gas mixture and surfactants supported the 3D growth of the pencil-shape n-type GaN core. Desired narrow distributions of shape, diameter and height were achieved. The arrangement of the NAMs was controlled by patterns etched into SiO{sub 2} masks deposited on GaN templates. The active layer (InGaN/GaN SQW and MQWs) and the layer for the p-side were deposited with 2D-like conditions wrapped around the core. The crystalline quality of the NAMs, shell growth rates and the Indium distribution were investigated by high resolution transmission electron microscopy. Furthermore, optical emission was studied using density-dependent photoluminescence spectroscopy.

  6. RIDES: Robust Intrusion Detection System for IP-Based Ubiquitous Sensor Networks

    Directory of Open Access Journals (Sweden)

    Sungwon Lee

    2009-05-01

    Full Text Available TheIP-based Ubiquitous Sensor Network (IP-USN is an effort to build the “Internet of things”. By utilizing IP for low power networks, we can benefit from existing well established tools and technologies of IP networks. Along with many other unresolved issues, securing IP-USN is of great concern for researchers so that future market satisfaction and demands can be met. Without proper security measures, both reactive and proactive, it is hard to envisage an IP-USN realm. In this paper we present a design of an IDS (Intrusion Detection System called RIDES (Robust Intrusion DEtection System for IP-USN. RIDES is a hybrid intrusion detection system, which incorporates both Signature and Anomaly based intrusion detection components. For signature based intrusion detection this paper only discusses the implementation of distributed pattern matching algorithm with the help of signature-code, a dynamically created attack-signature identifier. Other aspects, such as creation of rules are not discussed. On the other hand, for anomaly based detection we propose a scoring classifier based on the SPC (Statistical Process Control technique called CUSUM charts. We also investigate the settings and their effects on the performance of related parameters for both of the components.

  7. Integrating QoS and security functions in an IP-VPN gateway

    Science.gov (United States)

    Fan, Kuo-Pao; Chang, Shu-Hsin; Lin, Kuan-Ming; Pen, Mau-Jy

    2001-10-01

    IP-based Virtual Private Network becomes more and more popular. It can not only reduce the enterprise communication cost but also increase the revenue of the service provider. The common IP-VPN application types include Intranet VPN, Extranet VPN, and remote access VPN. For the large IP-VPN market, some vendors develop dedicated IP-VPN devices; while some vendors add the VPN functions into their existing network equipment such as router, access gateway, etc. The functions in the IP-VPN device include security, QoS, and management. The common security functions supported are IPSec (IP Security), IKE (Internet Key Exchange), and Firewall. The QoS functions include bandwidth control and packet scheduling. In the management component, policy-based network management is under standardization in IETF. In this paper, we discuss issues on how to integrate the QoS and security functions in an IP-VPN Gateway. We propose three approaches to do this. They are (1) perform Qos first (2) perform IPSec first and (3) reserve fixed bandwidth for IPSec. We also compare the advantages and disadvantages of the three proposed approaches.

  8. Long-term follow-up of a randomized controlled trial on additional core stability exercises training for improving dynamic sitting balance and trunk control in stroke patients.

    Science.gov (United States)

    Cabanas-Valdés, Rosa; Bagur-Calafat, Caritat; Girabent-Farrés, Montserrat; Caballero-Gómez, Fernanda Mª; du Port de Pontcharra-Serra, Helena; German-Romero, Ana; Urrútia, Gerard

    2017-03-01

    Analyse the effect of core stability exercises in addition to conventional physiotherapy training three months after the intervention ended. A randomized controlled trial. Outpatient services. Seventy-nine stroke survivors. In the intervention period, both groups underwent conventional physiotherapy performed five days/week for five weeks, and in addition the experimental group performed core stability exercises for 15 minutes/day. Afterwards, during a three-month follow-up period, both groups underwent usual care that could eventually include conventional physiotherapy or physical exercise but not in a controlled condition. Primary outcome was trunk control and dynamic sitting balance assessed by the Spanish-Version of Trunk Impairment Scale 2.0 and Function in Sitting Test. Secondary outcomes were standing balance and gait evaluated by the Berg Balance Scale, Tinetti Test, Brunel Balance Assessment, Spanish-Version of Postural Assessment Scale for Stroke and activities of daily living using the Barthel Index. A total of 68 subjects out of 79 completed the three-month follow-up period. The mean difference (SD) between groups was 0.78 (1.51) points ( p = 0.003) for total score on the Spanish-Version of Trunk Impairment Scale 2.0, 2.52 (6.46) points ( p = 0.009) for Function in Sitting Test, dynamic standing balance was 3.30 (9.21) points ( p= 0.009) on the Berg Balance Scale, gait was 0.82 (1.88) points ( p = 0.002) by Brunel Balance Assessment (stepping), and 1.11 (2.94) points ( p = 0.044) by Tinetti Test (gait), all in favour of core stability exercises. Core stability exercises plus conventional physiotherapy have a positive long-term effect on improving dynamic sitting and standing balance and gait in post-stroke patients.

  9. The Predigest Project of TCP/IP Protocol Communication System Based on DSP Technology and Ethernet

    Science.gov (United States)

    hong-you, Wang; san-ping, Zhao

    The paper introduce a predigest project of TCP/IP based on DSP CMOS chip TMS320F2407 and Ethernet interface. The system design the Network Interface Controller using TMS320F2407and TRL8019AS,it simplify TCP/IP, achieve simple protocol stack in DSP, and achieve Data transmission by software program. The experiment indicated that, the communication system constructed by TMS320F2407andTRL8019AS is low cast, simple and reliable.

  10. Pilates based core stability training in ambulant individuals with multiple sclerosis: protocol for a multi-centre randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Freeman Jennifer

    2012-04-01

    Full Text Available Abstract Background People with Multiple Sclerosis (MS frequently experience balance and mobility impairments, including reduced trunk stability. Pilates-based core stability training, which is aimed at improving control of the body's stabilising muscles, is popular as a form of exercise with people with MS and therapists. A replicated single case series study facilitated by the Therapists in MS Group in the United Kingdom (UK provides preliminary evidence that this approach can improve balance and mobility in ambulant people with MS; further evidence is needed to substantiate these findings to ensure that limited time, energy, finances and resources are used to best effect. This study builds upon the pilot work undertaken in the case series study by implementing a powered randomised controlled study, with the aims of: 1 Establishing the effectiveness of core stability training 2 Comparing core stability training with standardised physiotherapy exercise 3 Exploring underlying mechanisms of change associated with this intervention Methods This is a multi-centre, double blind, block randomised, controlled trial. Eligible participants will be recruited from 4 UK centres. Participants will be randomly allocated to one of three groups: Pilates based core stability training, standardised physiotherapy exercise or contract-relax relaxation sessions (placebo control. All will receive face to face training sessions over a 12 week period; together with a 15 minute daily home programme. All will be assessed by a blinded assessor before training, at the end of the 12 week programme and at 4 week follow-up. The primary outcome measure is the 10 metre timed walk. Secondary outcome measures are the MS walking Scale (MSWS-12, the Functional Reach (forwards and lateral, a 10 point Numerical Rating Scale to determine "Difficulty in carrying a drink when walking", and the Activities-specific Balance Confidence (ABC Scale. In addition, ultrasound imaging of the

  11. Tracing the spiral arms in IP Pegasi

    NARCIS (Netherlands)

    Baptista, R.; Morales-Rueda, L.; Harlaftis, E.T.; Marsh, T.R.; Steeghs, D.

    2005-01-01

    We report the analysis of time-resolved spectroscopy of IP Pegasi in outburst with eclipse mapping techniques to investigate the location and geometry of the observed spiral structures. We were able to obtain an improved view of the spiral structures with the aid of light curves extracted in

  12. IP validation in remote microelectronics testing

    Science.gov (United States)

    Osseiran, Adam; Eshraghian, Kamran; Lachowicz, Stefan; Zhao, Xiaoli; Jeffery, Roger; Robins, Michael

    2004-03-01

    This paper presents the test and validation of FPGA based IP using the concept of remote testing. It demonstrates how a virtual tester environment based on a powerful, networked Integrated Circuit testing facility, aimed to complement the emerging Australian microelectronics based research and development, can be employed to perform the tasks beyond the standard IC test. IC testing in production consists in verifying the tested products and eliminating defective parts. Defects could have a number of different causes, including process defects, process migration and IP design and implementation errors. One of the challenges in semiconductor testing is that while current fault models are used to represent likely faults (stuck-at, delay, etc.) in a global context, they do not account for all possible defects. Research in this field keeps growing but the high cost of ATE is preventing a large community from accessing test and verification equipment to validate innovative IP designs. For these reasons a world class networked IC teletest facility has been established in Australia under the support of the Commonwealth government. The facility is based on a state-of-the-art semiconductor tester operating as a virtual centre spanning Australia and accessible internationally. Through a novel approach the teletest network provides virtual access to the tester on which the DUT has previously been placed. The tester software is then accessible as if the designer is sitting next to the tester. This paper presents the approach used to test and validate FPGA based IPs using this remote test approach.

  13. ChIP-chip versus ChIP-seq: Lessons for experimental design and data analysis

    Directory of Open Access Journals (Sweden)

    Karchenko Peter V

    2011-02-01

    Full Text Available Abstract Background Chromatin immunoprecipitation (ChIP followed by microarray hybridization (ChIP-chip or high-throughput sequencing (ChIP-seq allows genome-wide discovery of protein-DNA interactions such as transcription factor bindings and histone modifications. Previous reports only compared a small number of profiles, and little has been done to compare histone modification profiles generated by the two technologies or to assess the impact of input DNA libraries in ChIP-seq analysis. Here, we performed a systematic analysis of a modENCODE dataset consisting of 31 pairs of ChIP-chip/ChIP-seq profiles of the coactivator CBP, RNA polymerase II (RNA PolII, and six histone modifications across four developmental stages of Drosophila melanogaster. Results Both technologies produce highly reproducible profiles within each platform, ChIP-seq generally produces profiles with a better signal-to-noise ratio, and allows detection of more peaks and narrower peaks. The set of peaks identified by the two technologies can be significantly different, but the extent to which they differ varies depending on the factor and the analysis algorithm. Importantly, we found that there is a significant variation among multiple sequencing profiles of input DNA libraries and that this variation most likely arises from both differences in experimental condition and sequencing depth. We further show that using an inappropriate input DNA profile can impact the average signal profiles around genomic features and peak calling results, highlighting the importance of having high quality input DNA data for normalization in ChIP-seq analysis. Conclusions Our findings highlight the biases present in each of the platforms, show the variability that can arise from both technology and analysis methods, and emphasize the importance of obtaining high quality and deeply sequenced input DNA libraries for ChIP-seq analysis.

  14. KONSTRUKSI SOSIAL GURU IPS TENTANG PEMBELAJARAN IPS DI MTS KECAMATAN KOTA SUMENEP

    Directory of Open Access Journals (Sweden)

    Hamidi Rasyid

    2015-08-01

    Full Text Available Tujuan penelitian ini mendeskripsikan tentang (1 mengetahui konstruksi sosial guru IPS, (2 Implementasi pembelajaran guru di Kelas, (3 Paradigma kepala sekolah tentang pembelajaran IPS.Metode penelitian menggunakan kualitatif, tujuan utama dari penelitian ini adalah untuk menggali substansi mendasar dibalik fakta yang terjadi pada guru IPS. Hasil penelitian menunjukkan bahwa guru IPS mengkonstruksikan IPS menjadi empat konstruksi, (1 IPS adalah ilmu pengetahuan sosial yang peserta didik diharuskan bisa bersikap sosial yang baik sebagai perwujudan dari ilmu pengetahuan sosial, (2 IPS adalah mengkaji kehidupan sehari-hari dan masalah sosial yang ada dalam masyarakat, (3 IPS adalah mengkaji tentang hubungan manusia baik individu dengan individu, individu dengan kelompok maupun kelompok dengan kelompok, (4 IPS adalah mata pelajaran yang di dalamnya ada mata pelajaran sejarah, geografi, sosiologi dan ekonomi. This study describes the purpose of (1 determine the social construction of social studies teachers, (2 Implementation of teacher learning in class, (3 the principal of the learning paradigm of social studies. Using qualitative research methods, the main purpose of this study was to explore the fundamental substance behind the facts that occurred in social studies teacher. The results showed that teachers of social studies constructs into four construction, (1 social studies is a social studies that students are required to be good social as the embodiment of social studies, (2 social studies is reviewing everyday life and social problems that exist in the community, (3 social studies is to examine whether individual human relationships with individuals, groups of individuals and groups with the group, (4 social studiess are subjects in which there is the eye the lessons of history, geography, sociology and economics

  15. Evaluation of advanced cooling therapy's esophageal cooling device for core temperature control.

    Science.gov (United States)

    Naiman, Melissa; Shanley, Patrick; Garrett, Frank; Kulstad, Erik

    2016-05-01

    Managing core temperature is critical to patient outcomes in a wide range of clinical scenarios. Previous devices designed to perform temperature management required a trade-off between invasiveness and temperature modulation efficiency. The Esophageal Cooling Device, made by Advanced Cooling Therapy (Chicago, IL), was developed to optimize warming and cooling efficiency through an easy and low risk procedure that leverages heat transfer through convection and conduction. Clinical data from cardiac arrest, fever, and critical burn patients indicate that the Esophageal Cooling Device performs very well both in terms of temperature modulation (cooling rates of approximately 1.3°C/hour, warming of up to 0.5°C/hour) and maintaining temperature stability (variation around goal temperature ± 0.3°C). Physicians have reported that device performance is comparable to the performance of intravascular temperature management techniques and superior to the performance of surface devices, while avoiding the downsides associated with both.

  16. Multi-core System Architecture for Safety-critical Control Applications

    DEFF Research Database (Denmark)

    Li, Gang

    (SIL). The certification cost of each component is in the direct proportion to its SIL. In order to integrate such applications into one platform, all components have to be certified to the highest SIL, if no sufficient isolation is provided between each other. Consequently, it increases the total...... the frequency of a processor. In a typical federated architecture, each component of a specific SIL can be allocated on a dedicated ECU, and thus is isolated from components on other ECUs. However, using more ECUs has weaknesses such as error-prone inter-processor (off-chip) connections, large hardware weight...... and size, and high power consumption. Increasing the frequency of a processor is becoming painful now due to the explosive power consumption. Furthermore, components integrated into a single-core processor have to be certified to the highest SIL, due to that no isolation is provided in a traditional single...

  17. Core-in-cup tablet design of metoprolol succinate and its evaluation for controlled release.

    Science.gov (United States)

    Nagaraju, Ravouru; Meera, Durgumahanthi Sai; Kaza, Rajesh; Arvind, Vakati Venkata; Venkateswarlu, Vobalaboina

    2009-12-01

    The core-in-cup matrix tablets of Metoprolol succinate were prepared by wet granulation technique. Of all the investigated formulations, the optimized formulation of MS-09 followed zero-order kinetics of drug release. Trail on MS-09 was formulated using 7.5% hydrogenated castor-oil (HCO) and 4% of hydroxyl propyl methylcellulose (HPMC K15M) with an objective to achieve a linear release profile for 24 h. There is no initial burst release, with 16.17% of drug released during the first hour and release was extended up to 24 hrs. Study of drug release kinetics was performed by application of dissolution data to various kinetic equations like zero-order; first order, Higuchi and Korsmeyer-Peppas, from R(2) value (0.9975) it was concluded that the drug release followed zero order kinetics with both erosion and diffusion as the release mechanisms.

  18. Getting to the core of locus of control: Is it an evaluation of the self or the environment?

    Science.gov (United States)

    Johnson, Russell E; Rosen, Christopher C; Chang, Chu-Hsiang Daisy; Lin, Szu-Han Joanna

    2015-09-01

    Responding to criticisms surrounding the structural validity of the higher order core self-evaluations (CSE) construct, in the current study we examined the appropriateness of including locus of control as an indicator of CSE. Drawing from both theoretical and empirical evidence, we argue that locus of control is more heavily influenced by evaluations of the environment compared with the other CSE traits. Using data from 4 samples, we demonstrate that model fit for the higher order CSE construct is better when locus of control is excluded versus included as a trait indicator and that the shared variance between locus of control and CSE is nominal. This does not mean that locus of control is irrelevant for CSE theory though. We propose that evaluations of the environment moderate the relations that CSE has with its outcomes. To test this proposition, we collected data from 4 unique samples that included a mix of student and employee participants, self- and other-ratings, and cross-sectional and longitudinal data. Our results revealed that locus of control moderated relations of CSE with life and job satisfaction, and supervisor-rated job performance. CSE had stronger, positive relations with these outcomes when locus of control is internal versus external. These findings broaden CSE theory by demonstrating one way in which evaluations of the environment interface with evaluations of the self. (PsycINFO Database Record

  19. Investigation of Viral and Host Chromatin by ChIP-PCR or ChIP-Seq Analysis.

    Science.gov (United States)

    Günther, Thomas; Theiss, Juliane M; Fischer, Nicole; Grundhoff, Adam

    2016-02-08

    Complex regulation of viral transcription patterns and DNA replication levels is a feature of many DNA viruses. This is especially true for those viruses which establish latent or persistent infections (e.g., herpesviruses, papillomaviruses, polyomaviruses, or adenovirus), as long-term persistence often requires adaptation of gene expression programs and/or replication levels to the cellular milieu. A key factor in the control of such processes is the establishment of a specific chromatin state on promoters or replication origins, which in turn will determine whether or not the underlying DNA is accessible for other factors that mediate downstream processes. Chromatin immunoprecipitation (ChIP) is a powerful technique to investigate viral chromatin, in particular to study binding patterns of modified histones, transcription factors or other DNA-/chromatin-binding proteins that regulate the viral lifecycle. Here, we provide protocols that are suitable for performing ChIP-PCR and ChIP-Seq studies on chromatin of large and small viral genomes.

  20. Effectiveness of Core Stability Exercises and Recovery Myofascial Release Massage on Fatigue in Breast Cancer Survivors: A Randomized Controlled Clinical Trial

    OpenAIRE

    Irene Cantarero-Villanueva; Carolina Fernández-Lao; Rosario del Moral-Avila; César Fernández-de-las-Peñas; María Belén Feriche-Fernández-Castanys; Manuel Arroyo-Morales

    2012-01-01

    The purpose of the present paper was to evaluate the effects of an 8-week multimodal program focused on core stability exercises and recovery massage with DVD support for a 6-month period in physical and psychological outcomes in breast cancer survivors. A randomized controlled clinical trial was performed. Seventy-eight (n = 78) breast cancer survivors were assigned to experimental (core stability exercises plus massage-myofascial release) and control (usual health care) groups. The interven...

  1. Genome-wide profiling of transcription factor binding and epigenetic marks in adipocytes by ChIP-seq

    DEFF Research Database (Denmark)

    Nielsen, Ronni; Mandrup, Susanne

    2014-01-01

    The recent advances in high-throughput sequencing combined with various other technologies have allowed detailed and genome-wide insight into the transcriptional networks that control adipogenesis. Chromatin immunoprecipitation (ChIP) combined with high-throughput sequencing (ChIP-seq) is one...

  2. Weibull analysis and flexural strength of hot-pressed core and veneered ceramic structures.

    Science.gov (United States)

    Bona, Alvaro Della; Anusavice, Kenneth J; DeHoff, Paul H

    2003-11-01

    To test the hypothesis that the Weibull moduli of single- and multilayer ceramics are controlled primarily by the structural reliability of the core ceramic.Methods. Seven groups of 20 bar specimens (25 x 4 x 1.2 mm) were made from the following materials: (1) IPS Empress--a hot-pressed (HP) leucite-based core ceramic; (2) IPS Empress2--a HP lithia-based core ceramic; (3 and 7) Evision--a HP lithia-based core ceramic (ES); (4) IPS Empress2 body--a glass veneer; (5) ES (1.1 mm thick) plus a glaze layer (0.1 mm); and (6) ES (0.8 mm thick) plus veneer (0.3 mm) and glaze (0.1 mm). Each specimen was subjected to four-point flexure loading at a cross-head speed of 0.5 mm/min while immersed in distilled water at 37 degrees C, except for Group 7 that was tested in a dry environment. Failure loads were recorded and the fracture surfaces were examined using SEM. ANOVA and Duncan's multiple range test were used for statistical analysis. No significant differences were found between the mean flexural strength values of Groups 2, 3, 5, and 6 or between Groups 1 and 4 (p>0.05). However, significant differences were found for dry (Group 7) and wet (Groups 1-6) conditions. Glazing had no significant effect on the flexural strength or Weibull modulus. The strength and Weibull modulus of the ES ceramic were similar to those of Groups 5 and 6. The structural reliability of veneered core ceramic is controlled primarily by that of the core ceramic.

  3. Dimensional stability control of ultrathin core%薄芯板尺寸稳定性控制

    Institute of Scientific and Technical Information of China (English)

    罗晓帆

    2014-01-01

    任意层互连板件制作过程中,板件变形导致盲孔底部连接盘偏是最常见的失效模式,特别第一次薄芯板压合,尺寸稳定性控制极有难度。本文通过研究板料、芯板配本及压合参数,分析其对拼板整体变形的影响,从而得出薄芯板尺寸稳定性控制的最佳方案。%During ALIVH PCB manufacturing process, the misregistration of target pad due to the PCB dimensional change is the most common failure modes. Especially, when the first pressing cycle, dimensional stability control of the ultrathin core is very difficult. By means of analyzing laminate material, core stack-up and press parameter, which affect the PCB dimensional stability, this article sheds light on the best method of dimensional stability control.

  4. The effect of additional core stability exercises on improving dynamic sitting balance and trunk control for subacute stroke patients: a randomized controlled trial.

    Science.gov (United States)

    Cabanas-Valdés, Rosa; Bagur-Calafat, Caritat; Girabent-Farrés, Montserrat; Caballero-Gómez, Fernanda Mª; Hernández-Valiño, Montserrat; Urrútia Cuchí, Gerard

    2016-10-01

    To examine the effect of core stability exercises on trunk control, dynamic sitting and standing balance, gait, and activities of daily living in subacute stroke patients. A randomized controlled trial. Inpatient rehabilitation hospital in two centres. Eighty patients (mean of 23.25 (±16.7) days post-stroke) were randomly assigned to an experimental group and a control group. Both groups underwent conventional therapy for five days/week for five weeks and the experimental group performed core stability exercises for 15 min/day. The patients were assessed before and after intervention. The Trunk Impairment Scale (Spanish-Version) and Function in Sitting Test were used to measure the primary outcome of dynamic sitting balance. Secondary outcome measures were standing balance and gait as evaluated via Berg Balance Scale, Tinetti Test, Brunel Balance Assessment, Postural Assessment Scale for Stroke (Spanish-Version), and activities of daily living using Barthel Index. The experimental group showed statistically significant differences for all of the total scale scores (PCore stability exercises in addition to conventional therapy improves trunk control, dynamic sitting balance, standing balance, gait and activities of daily living in subacute post-stroke patients. © The Author(s) 2015.

  5. Architecture and Design of IP Broadcasting System Using Passive Optical Network

    Science.gov (United States)

    Ikeda, Hiroki; Sugawa, Jun; Ashi, Yoshihiro; Sakamoto, Kenichi

    We propose an IP broadcasting system architecture using passive optical networks (PON) utilizing the optical broadcast links of a PON with a downstream bandwidth allocation algorithm to provide a multi-channel IP broadcasting service to home subscribers on single broadband IP network infrastructures. We introduce the design and adaptation of the optical broadcast links to effectively broadcast video contents to home subscribers. We present a performance analysis that includes the downstream bandwidth utilization efficiency of the broadcast link and the bandwidth control of the IP broadcasting and Internet data. Our analysis and simulation results show that the proposed system can provide 100 HDTV channels to every user over fiber lines. We also propose an IPTV channel selection mechanism in an ONT by selecting a broadcast stream. We developed and evaluated a prototype that can achieve a 15-msec IPTV channel selection speed.

  6. Video Conference Based on VoIP MCU Subsystem Design%基于VoIP视频会议的MCU子系统设计

    Institute of Scientific and Technical Information of China (English)

    周康; 雷建锋

    2012-01-01

    Based on the VoIP network phone concept as well as the video conference presentations, as well as the VoIP in video conference system has been widely used. MCU video conference is core component, it can be said to be a video conference in the brain, in a video conferencing system, MCU(multipoint control unit) the main function is to coordinate and control the plurality of terminal of video transmission. This article is from the video conference system is the core component of the MCU subsystem of. On the function of the MCU and MCU and VoIP signaling conversion to the design of the system. System in the VC+ + 6 development platform, using C/S mode.%通过对VoIP网络电话的概念以及视频会议的介绍,以及当今视频会议系统中VoIP被广泛应用.MCU是视频会议的核心组成部分,它可以说是视频会议的大脑,在视频会议系统中,MCU(多点控制单元)主要功能是协调及控制多个终端间的视讯传输.文章主要是从视频会议系统最核心的组成部分MCU子系统人手.对MCU功能以及MCU和VoIP信令转换方面来设计该系统.系统是在VC++6.0平台下开发,采用C/S模式实现的.

  7. Coaxial GaAs-AlGaAs core-multishell nanowire lasers with epitaxial gain control

    Energy Technology Data Exchange (ETDEWEB)

    Stettner, T., E-mail: Thomas.Stettner@wsi.tum.de, E-mail: Gregor.Koblmueller@wsi.tum.de, E-mail: Jonathan.Finley@wsi.tum.de; Zimmermann, P.; Loitsch, B.; Regler, A.; Mayer, B.; Winnerl, J.; Matich, S.; Riedl, H.; Kaniber, M.; Abstreiter, G.; Koblmüller, G., E-mail: Thomas.Stettner@wsi.tum.de, E-mail: Gregor.Koblmueller@wsi.tum.de, E-mail: Jonathan.Finley@wsi.tum.de; Finley, J. J., E-mail: Thomas.Stettner@wsi.tum.de, E-mail: Gregor.Koblmueller@wsi.tum.de, E-mail: Jonathan.Finley@wsi.tum.de [Walter Schottky Institut and Physik Department, TU München, Garching 85748 (Germany); Döblinger, M. [Department of Chemistry, Ludwig-Maximilians-Universität München, Munich 81377 (Germany)

    2016-01-04

    We demonstrate the growth and single-mode lasing operation of GaAs-AlGaAs core-multishell nanowires (NW) with radial single and multiple GaAs quantum wells (QWs) as active gain media. When subject to optical pumping lasing emission with distinct s-shaped input-output characteristics, linewidth narrowing and emission energies associated with the confined QWs are observed. Comparing the low temperature performance of QW NW laser structures having 7 coaxial QWs with a nominally identical structure having only a single QW shows that the threshold power density reduces several-fold, down to values as low as ∼2.4 kW/cm{sup 2} for the multiple QW NW laser. This confirms that the individual radial QWs are electronically weakly coupled and that epitaxial design can be used to optimize the gain characteristics of the devices. Temperature-dependent investigations show that lasing prevails up to 300 K, opening promising new avenues for efficient III–V semiconductor NW lasers with embedded low-dimensional gain media.

  8. IP-Switch网络通信业务%Communication Services of IP-Switch Network

    Institute of Scientific and Technical Information of China (English)

    马泽旭; 邢兆宏

    2005-01-01

    IP-Switch网是基于IP网络、采用软交换体系架构的、新一代网络通信平台,具有强大的业务提供能力及良好的业务扩展能力,给企业带来很大的收益.介绍IP-Switch网的业务种类、接入方式和实现方法.

  9. Opportunities for IP  in Communications Beyond 3G

    DEFF Research Database (Denmark)

    Nielsen, Thomas Toftegaard; Jacobsen, Rune H.

    2005-01-01

    Future communication will be based on TCP/IP as common network and transport layers to provide global connectivity to users and applications. IP is used to provide ubiquitous access across different access networks and exploits the benefits of a common connectivity layer while reducing the cost...... of operation and maintenance of the network. This paper discusses the opportunities for IP in the evolution towards a future broadband, all-IP mobile communication network. In particular, we argue for three opportunities for the future: Interworking access technologies over IP, IP layer transparency...

  10. Inflammation and Atrophy Precede Prostate Neoplasia in PhIP Induced Rat Model

    Energy Technology Data Exchange (ETDEWEB)

    Borowsky, A D; Dingley, K; Ubick, E; Turteltaub, K; Cardiff, R D; DeVere-White, R

    2006-06-01

    2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) has been implicated as a major mutagenic heterocyclic amine in the human diet and is carcinogenic in the rat prostate. In order to validate PhIP induced rat prostate neoplasia as a model of human prostate cancer progression, we sought to study the earliest histologic and morphologic changes in the prostate and to follow the progressive changes over time. We fed 67 male Fischer F344 5 week old rats with PhIP (400 PPM) or control diets for 20 weeks, and then sacrificed animals for histomorphologic examination at age 25 weeks, 45 weeks, and 65 weeks. Animals treated with PhIP showed significantly more inflammation (P=.002 (25wk), >.001(45wk), .016(65wk)) and atrophy (P=.003(25wk), >.001(45wk), .006 (65wk)) in their prostate glands relative to controls. Prostatic intraepithelial neoplasia (PIN) occurred only in PhIP treated rats. PIN lesions arose in areas of glandular atrophy, most often in the ventral prostate. Atypical cells in areas of atrophy show loss of glutathione S-transferase pi immunostaining preceding development of PIN. None of the animals in this study developed invasive carcinomas differing from previous reports. Overall, these findings suggest that the pathogenesis of prostatic neoplasia in the PhIP treated rat prostate proceeds from inflammation to post-inflammatory proliferative atrophy to PIN.

  11. Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model

    Directory of Open Access Journals (Sweden)

    Alexander D. Borowsky

    2006-09-01

    Full Text Available 2-Amino-1-methyl-6-phenylimidazo(4,5-bpyridine (PhIP has been implicated as a major mutagenic heterocyclicamine in the human diet and is carcinogenic in the rat prostate. To validate PhIP-induced rat prostatic neoplasia as a model of human prostate cancer progression, we sought to study the earliest histologic and morphologic changes in the prostate and to follow progressive changes over time. We fed sixty-seven 5-week-old male Fischer F344 rats with PhIP (400 ppm or control diets for 20 weeks, and then sacrificed animals for histomorphologic examination at the ages of 25, 45, and 65 weeks. Animals treated with PhIP showed significantly more inflammation (P = .002, > .001, and .016 for 25, 45, and 65 weeks, respectively and atrophy (P = .003, > .001, and .006 for 25, 45, and 65 weeks, respectively in their prostate glands relative to controls. Prostatic intraepithelial neoplasia (PIN occurred only in PhIP-treated rats. PIN lesions arose in areas of glandular atrophy, most often in the ventral prostate. Atypical cells in areas of atrophy show loss of glutathione S-transferase π immunostaining preceding the development of PIN.None of the animals in this study developed invasive carcinomas, differing from those in previous reports. Overall, these findings suggest that the pathogenesis of prostatic neoplasia in the PhIP-treated rat prostate proceeds from inflammation to postinflammatory proliferative atrophy to PIN.

  12. Stimulation of inositol 1,4,5-trisphosphate (IP3 receptor subtypes by analogues of IP3.

    Directory of Open Access Journals (Sweden)

    Huma Saleem

    Full Text Available Most animal cells express mixtures of the three subtypes of inositol 1,4,5-trisphosphate receptor (IP(3R encoded by vertebrate genomes. Activation of each subtype by different agonists has not hitherto been examined in cells expressing defined homogenous populations of IP(3R. Here we measure Ca(2+ release evoked by synthetic analogues of IP(3 using a Ca(2+ indicator within the lumen of the endoplasmic reticulum of permeabilized DT40 cells stably expressing single subtypes of mammalian IP(3R. Phosphorylation of (1,4,5IP(3 to (1,3,4,5IP(4 reduced potency by ~100-fold. Relative to (1,4,5IP(3, the potencies of IP(3 analogues modified at the 1-position (malachite green (1,4,5IP(3, 2-position (2-deoxy(1,4,5IP(3 or 3-position (3-deoxy(1,4,5IP(3, (1,3,4,5IP(4 were similar for each IP(3R subtype. The potency of an analogue, (1,4,6IP(3, in which the orientations of the 2- and 3-hydroxyl groups were inverted, was also reduced similarly for all three IP(3R subtypes. Most analogues of IP(3 interact similarly with the three IP(3R subtypes, but the decrease in potency accompanying removal of the 1-phosphate from (1,4,5IP(3 was least for IP(3R3. Addition of a large chromophore (malachite green to the 1-phosphate of (1,4,5IP(3 only modestly reduced potency suggesting that similar analogues could be used to measure (1,4,5IP(3 binding optically. These data provide the first structure-activity analyses of key IP(3 analogues using homogenous populations of each mammalian IP(3R subtype. They demonstrate broadly similar structure-activity relationships for all mammalian IP(3R subtypes and establish the potential utility of (1,4,5IP(3 analogues with chromophores attached to the 1-position.

  13. Instalación de una oficina con infraestructura IP

    OpenAIRE

    Castillo Cabrera, Jose Manuel

    2015-01-01

    Se dota a una oficina en estado de ampliación de una infraestructura IP más actualizada modernizando su infraestructura de red cableada mediante el cambio de electrónica, se mejoran velocidades, topología, enlaces. La red inalámbrica, se le dota de un mayor control, seguridad y escalabilidad. Se proponen servidores redundantes vitalizados, con un sistema de copia en NAS. Se estructuran los servicios y ofrecen directrices claras hacia la virtualización de aplicaciones como futuro i...

  14. Adjusting the IP $\\beta$ Functions in RHIC

    CERN Document Server

    Wittmer, W; Pilat, F; Ptitsyn, V; Van Zeijts, J

    2004-01-01

    The beta functions at the IP can be adjusted without perturbation of other optics functions via several approaches. In this paper we describe a scheme based on a vector knob, which assigns fixed values to the different tuning quadrupoles and scales them by a common multiplier. The values for the knob vector were calculated for a lattice without any errors using MADX. Previous studies for the LHC [1] have shown that this approach can meet the design goals. A specific feature of the RHIC lattice is the nested power supply system. To cope with the resulting problems a detailed response matrix analysis has been carried out and different sets of knobs were calculated and compared. The knobs were tested at RHIC during the 2004 run and preliminary results are discussed. Simultaneously a new approach to measure the beam sizes of both colliding beams at the IP, based on the tunability provided by the knobs, was developed and tested.

  15. Automatic Classification of Attacks on IP Telephony

    Directory of Open Access Journals (Sweden)

    Jakub Safarik

    2013-01-01

    Full Text Available This article proposes an algorithm for automatic analysis of attack data in IP telephony network with a neural network. Data for the analysis is gathered from variable monitoring application running in the network. These monitoring systems are a typical part of nowadays network. Information from them is usually used after attack. It is possible to use an automatic classification of IP telephony attacks for nearly real-time classification and counter attack or mitigation of potential attacks. The classification use proposed neural network, and the article covers design of a neural network and its practical implementation. It contains also methods for neural network learning and data gathering functions from honeypot application.

  16. Fast Echo Canceller in IP Telephony Gateway

    Institute of Scientific and Technical Information of China (English)

    黄永峰; 李星

    2003-01-01

    The length of the echo path in the IP telephony system is very long. Generally, the echo canceller is implemented on the IP telephony gateway which needs to perform concurrently multi-channel echo cancellation and voice compression. Hence, the most key technique to design the echo canceller is to reduce greatly the computational requirement. For this reason a number of innovative features to implement a fast echo canceller are presented. The key components of this canceller include: the separation of adaptive and cancel filters, non-real-time adaptation and real-time cancellation, sharing VAD algorithms with the speech codec, the incorporation of delay indexing with zero coefficients, and windowing the adaptive filter coefficients to reduce the cost of DSP during the cancellation. Finally, the performance of the echo canceller is summarized; the results of evaluation show that the performance gains for echo cancellation are significant.

  17. Content Distribution over IP : Developments and Challenges

    OpenAIRE

    Popescu, Adrian; Kouvatsos, Demetres; Remondo, David; Giordano, Stefano

    2006-01-01

    This chapter focuses on the multimedia distribution over Internet IP under the auspices of the NoE Euro-NGI research project "Routing in Overlay Networks (ROVER)". The multimedia distribution is supported by several components such as services, content distribution chain, protocols and standards whilst Internet is used for content, acquisition, management and delivery as well as an Internet; Protocol Television (IPTV) infrastructure with QoS facilities. As the convergence between fi...

  18. iPS cells and personalized medicine

    OpenAIRE

    2014-01-01

    iPS cells and personalized medicine Personalized medicine uses patient's genotype and/or level of gene expression for selection of medication, therapy or preventative measures. One of the best approaches for developing patient specific therapy is to use patient specific cells as in vitro drug testing model. Furthermore, patent specific cells in vitro enriched and modified can be used for autologous cell transplantation for treating numerous degenerative conditions.

  19. IP Network Management Model Based on NGOSS

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jin-yu; LI Hong-hui; LIU Feng

    2004-01-01

    This paper addresses a management model for IP network based on Next Generation Operation Support System (NGOSS). It makes the network management on the base of all the operation actions of ISP, It provides QoS to user service through the whole path by providing end-to-end Service Level Agreements (SLA) management through whole path. Based on web and coordination technology, this paper gives an implement architecture of this model.

  20. A native IP satellite communications system

    Science.gov (United States)

    Koudelka, O.; Schmidt, M.; Ebert, J.; Schlemmer, H.; Kastner-Puschl, S.; Riedler, W.

    2004-08-01

    ≪ In the framework of ESA's ARTES-5 program the Institute of Applied Systems Technology (Joanneum Research) in cooperation with the Department of Communications and Wave Propagation has developed a novel meshed satellite communications system which is optimised for Internet traffic and applications (L*IP—Local Network Interconnection via Satellite Systems Using the IP Protocol Suite). Both symmetrical and asymmetrical connections are supported. Bandwidth on demand and guaranteed quality of service are key features of the system. A novel multi-frequency TDMA access scheme utilises efficient methods of IP encapsulation. In contrast to other solutions it avoids legacy transport network techniques. While the DVB-RCS standard is based on ATM or MPEG transport cells, the solution of the L*IP system uses variable-length cells which reduces the overhead significantly. A flexible and programmable platform based on Linux machines was chosen to allow the easy implementation and adaptation to different standards. This offers the possibility to apply the system not only to satellite communications, but provides seamless integration with terrestrial fixed broadcast wireless access systems. The platform is also an ideal test-bed for a variety of interactive broadband communications systems. The paper describes the system architecture and the key features of the system.

  1. Growth control, structure, chemical state, and photoresponse of CuO-CdS core-shell heterostructure nanowires.

    Science.gov (United States)

    El Mel, A A; Buffière, M; Bouts, N; Gautron, E; Tessier, P Y; Henzler, K; Guttmann, P; Konstantinidis, S; Bittencourt, C; Snyders, R

    2013-07-05

    The growth of single-crystal CuO nanowires by thermal annealing of copper thin films in air is studied. We show that the density, length, and diameter of the nanowires can be controlled by tuning the morphology and structure of the copper thin films deposited by DC magnetron sputtering. After identifying the optimal conditions for the growth of CuO nanowires, chemical bath deposition is employed to coat the CuO nanowires with CdS in order to form p-n nanojunction arrays. As revealed by high-resolution TEM analysis, the thickness of the polycrystalline CdS shell increases when decreasing the diameter of the CuO core for a given time of CdS deposition. Near-edge x-ray absorption fine-structure spectroscopy combined with transmission x-ray microscopy allows the chemical analysis of isolated nanowires. The absence of modification in the spectra at the Cu L and O K edges after the deposition of CdS on the CuO nanowires indicates that neither Cd nor S diffuse into the CuO phase. We further demonstrate that the core-shell nanowires exhibit the I-V characteristic of a resistor instead of a diode. The electrical behavior of the device was found to be photosensitive, since increasing the incident light intensity induces an increase in the collected electrical current.

  2. PICS: probabilistic inference for ChIP-seq.

    Science.gov (United States)

    Zhang, Xuekui; Robertson, Gordon; Krzywinski, Martin; Ning, Kaida; Droit, Arnaud; Jones, Steven; Gottardo, Raphael

    2011-03-01

    ChIP-seq combines chromatin immunoprecipitation with massively parallel short-read sequencing. While it can profile genome-wide in vivo transcription factor-DNA association with higher sensitivity, specificity, and spatial resolution than ChIP-chip, it poses new challenges for statistical analysis that derive from the complexity of the biological systems characterized and from variability and biases in its sequence data. We propose a method called PICS (Probabilistic Inference for ChIP-seq) for identifying regions bound by transcription factors from aligned reads. PICS identifies binding event locations by modeling local concentrations of directional reads, and uses DNA fragment length prior information to discriminate closely adjacent binding events via a Bayesian hierarchical t-mixture model. It uses precalculated, whole-genome read mappability profiles and a truncated t-distribution to adjust binding event models for reads that are missing due to local genome repetitiveness. It estimates uncertainties in model parameters that can be used to define confidence regions on binding event locations and to filter estimates. Finally, PICS calculates a per-event enrichment score relative to a control sample, and can use a control sample to estimate a false discovery rate. Using published GABP and FOXA1 data from human cell lines, we show that PICS' predicted binding sites were more consistent with computationally predicted binding motifs than the alternative methods MACS, QuEST, CisGenome, and USeq. We then use a simulation study to confirm that PICS compares favorably to these methods and is robust to model misspecification.

  3. Post-humanism, addiction and the loss of self-control: reflections on the missing core in addiction science.

    Science.gov (United States)

    Weinberg, Darin

    2013-05-01

    The core criterion of addiction is the loss of self control. Ironically enough, however, neither the social nor the biomedical sciences of addiction have so far made any measurable headway in linking drug use to a loss of self control. In this essay I begin by demonstrating the limitations in this regard suffered by the social and bio-medical sciences. Whereas the social sciences have variously reduced addicted drug use to deviant, but nonetheless self-governed, behaviour or discourses thereof, the bio-medical sciences have completely failed to adequately specify, let alone empirically analyse, how we might distinguish addicted from self-governed behaviour. I then show how these limitations can be very easily overcome by the adoption of a post-humanist perspective on self control and the various afflictions, including addiction, to which it is regarded heir. This argument provides occasion to acquaint readers with post-humanist scholarship concerning a spectrum of relevant topics including the human body, disease, drug use and therapeutic intervention and to show how these lines of investigation can be combined to provide an innovative, theoretically robust and practically valuable method for advancing the scientific study of addiction specifically as the loss of self control. The essay concludes with a discussion of some of the more important ramifications that follow from the adoption of this post-humanist approach for drug policy studies. Copyright © 2013 Elsevier B.V. All rights reserved.

  4. ChIP-Enrich: gene set enrichment testing for ChIP-seq data.

    Science.gov (United States)

    Welch, Ryan P; Lee, Chee; Imbriano, Paul M; Patil, Snehal; Weymouth, Terry E; Smith, R Alex; Scott, Laura J; Sartor, Maureen A

    2014-07-01

    Gene set enrichment testing can enhance the biological interpretation of ChIP-seq data. Here, we develop a method, ChIP-Enrich, for this analysis which empirically adjusts for gene locus length (the length of the gene body and its surrounding non-coding sequence). Adjustment for gene locus length is necessary because it is often positively associated with the presence of one or more peaks and because many biologically defined gene sets have an excess of genes with longer or shorter gene locus lengths. Unlike alternative methods, ChIP-Enrich can account for the wide range of gene locus length-to-peak presence relationships (observed in ENCODE ChIP-seq data sets). We show that ChIP-Enrich has a well-calibrated type I error rate using permuted ENCODE ChIP-seq data sets; in contrast, two commonly used gene set enrichment methods, Fisher's exact test and the binomial test implemented in Genomic Regions Enrichment of Annotations Tool (GREAT), can have highly inflated type I error rates and biases in ranking. We identify DNA-binding proteins, including CTCF, JunD and glucocorticoid receptor α (GRα), that show different enrichment patterns for peaks closer to versus further from transcription start sites. We also identify known and potential new biological functions of GRα. ChIP-Enrich is available as a web interface (http://chip-enrich.med.umich.edu) and Bioconductor package. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  5. Converging on a core cognitive deficit: the impact of various neurodevelopment insults on cognitive control.

    Directory of Open Access Journals (Sweden)

    Kally C O'Reilly

    2014-06-01

    Full Text Available Despite substantial effort and immense need, the treatment options for major neuropsychiatric illnesses like schizophrenia are limited and largely ineffective at improving the most debilitating cognitive symptoms that are central to mental illness. These symptoms include cognitive control deficits, the inability to selectively use information that is currently relevant and ignore what is currently irrelevant. Contemporary attempts to accelerate progress are in part founded on an effort to reconceptualize neuropsychiatric illness as a disorder of neural development. This neurodevelopmental framework emphasizes abnormal neural circuits on the one hand, and on the other, it suggests there are therapeutic opportunities to exploit the developmental processes of excitatory neuron pruning, inhibitory neuron proliferation, elaboration of myelination, and other circuit refinements that extend through adolescence and into early adulthood. We have crafted a preclinical research program aimed at cognition failures that may be relevant to mental illness. By working with a variety of neurodevelopmental rodent models we strive to identify a common pathophysiology that underlies cognitive control failure as well as a common strategy for improving cognition in the face of neural circuit abnormalities. Here we review our work to characterize cognitive control deficits in rats with a neonatal ventral hippocampus lesion and rats that were exposed to Methylazoxymethanol acetate (MAM in utero. We review our findings as they pertain to early developmental processes, including neurogenesis, as well as the power of cognitive experience to refine neural circuit function within the mature and maturing brain’s cognitive circuitry.

  6. Generation of iPS Cells from Granulosa Cells.

    Science.gov (United States)

    Mao, Jian; Liu, Lin

    2016-01-01

    Various types of somatic cells can be reprogrammed to induced pluripotent stem (iPS) cells. Somatic stem cells may generate iPS cells more efficiently than do differentiated cells. We show that granulosa cells exhibit characteristic of somatic stem cells and can be reprogrammed to iPS cells more efficiently or with few factors. Here, we describe generation of mouse and pig iPS cells from granulosa cells with high efficiency.

  7. High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART

    Science.gov (United States)

    Ramirez, L. A.; Arango, T. A.; Thompson, E.; Naji, M.; Tebas, P.; Boyer, J. D.

    2014-01-01

    HIV-1-infected subjects, despite control of viral replication with ART, have an altered immune cytokine/chemokine milieu. Changes in systemic cytokines and chemokines can alter immune responses. IP-10, in particular, has been associated with pathogenesis in a number of conditions, and we found that IP-10 is increased in serum in subjects who are HIV-1 infected and on stable ART compared with HIV-1-uninfected individuals. In a series of in vitro studies, we found that PBMCs exposed to IP-10 showed a significant decrease in the number of cells capable of secreting IFN-γ, as well as other cytokines, when stimulated with recall antigens. Furthermore, treatment with IP-10 led to decreased antigen-specific calcium signaling and MAPK38 phosphorylation. Importantly, the cytokines, as well as proliferative responses, could be enhanced with an IP-10 Nab. Our findings suggest that IP-10-modulating drugs may potentially enhance T cell responses to vaccination and HIV-1 in HIV+ subjects on ART. PMID:25157027

  8. Sensor proxy mobile IPv6 (SPMIPv6)--a novel scheme for mobility supported IP-WSNs.

    Science.gov (United States)

    Islam, Md Motaharul; Huh, Eui-Nam

    2011-01-01

    IP based Wireless Sensor Networks (IP-WSNs) are gaining importance for their broad range of applications in health-care, home automation, environmental monitoring, industrial control, vehicle telematics and agricultural monitoring. In all these applications, mobility in the sensor network with special attention to energy efficiency is a major issue to be addressed. Host-based mobility management protocols are not suitable for IP-WSNs because of their energy inefficiency, so network based mobility management protocols can be an alternative for the mobility supported IP-WSNs. In this paper we propose a network based mobility supported IP-WSN protocol called Sensor Proxy Mobile IPv6 (SPMIPv6). We present its architecture, message formats and also evaluate its performance considering signaling cost, mobility cost and energy consumption. Our analysis shows that with respect to the number of IP-WSN nodes, the proposed scheme reduces the signaling cost by 60% and 56%, as well as the mobility cost by 62% and 57%, compared to MIPv6 and PMIPv6, respectively. The simulation results also show that in terms of the number of hops, SPMIPv6 decreases the signaling cost by 56% and 53% as well as mobility cost by 60% and 67% as compared to MIPv6 and PMIPv6 respectively. It also indicates that proposed scheme reduces the level of energy consumption significantly.

  9. Numerical study of IP3-induced Ca2+ spiral pattern evolution

    Institute of Scientific and Technical Information of China (English)

    Tang Jun; Ma Jun; Yi Ming; Jia Ya

    2008-01-01

    The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate (IP3) on intracellular Ca2+spiral pattern evolution is studied numerically.The results indicate that when the IP3 concentration decreases from 0.27μM,a physiologically reasonable value,to different values,the spiral centre drifts to the edge of the medium and disappears for a small enough IP3 concentration.The instability of spiral pattern can be understood in terms of excitability-change controlled by the IP3 concentration.On the other hand,when the IP3 concentration increases from 0.27μM,a homogeneous area with a high Ca2+ concentration emerges and competes with the spiral pattern.A high enough IP3 concentration can lead the homogeneous area to occupy the whole medium.The instability of spiral pattern is ascribed to the change in stability of a stationary state with a high Ca2+ concentration.

  10. A novel addressing scheme for PMIPv6 based global IP-WSNs.

    Science.gov (United States)

    Islam, Md Motaharul; Huh, Eui-Nam

    2011-01-01

    IP based Wireless Sensor Networks (IP-WSNs) are being used in healthcare, home automation, industrial control and agricultural monitoring. In most of these applications global addressing of individual IP-WSN nodes and layer-three routing for mobility enabled IP-WSN with special attention to reliability, energy efficiency and end to end delay minimization are a few of the major issues to be addressed. Most of the routing protocols in WSN are based on layer-two approaches. For reliability and end to end communication enhancement the necessity of layer-three routing for IP-WSNs is generating significant attention among the research community, but due to the hurdle of maintaining routing state and other communication overhead, it was not possible to introduce a layer-three routing protocol for IP-WSNs. To address this issue we propose in this paper a global addressing scheme and layer-three based hierarchical routing protocol. The proposed addressing and routing approach focuses on all the above mentioned issues. Simulation results show that the proposed addressing and routing approach significantly enhances the reliability, energy efficiency and end to end delay minimization. We also present architecture, message formats and different routing scenarios in this paper.

  11. A Novel Addressing Scheme for PMIPv6 Based Global IP-WSNs

    Directory of Open Access Journals (Sweden)

    Md. Motaharul Islam

    2011-08-01

    Full Text Available IP based Wireless Sensor Networks (IP-WSNs are being used in healthcare, home automation, industrial control and agricultural monitoring. In most of these applications global addressing of individual IP-WSN nodes and layer-three routing for mobility enabled IP-WSN with special attention to reliability, energy efficiency and end to end delay minimization are a few of the major issues to be addressed. Most of the routing protocols in WSN are based on layer-two approaches. For reliability and end to end communication enhancement the necessity of layer-three routing for IP-WSNs is generating significant attention among the research community, but due to the hurdle of maintaining routing state and other communication overhead, it was not possible to introduce a layer-three routing protocol for IP-WSNs. To address this issue we propose in this paper a global addressing scheme and layer-three based hierarchical routing protocol. The proposed addressing and routing approach focuses on all the above mentioned issues. Simulation results show that the proposed addressing and routing approach significantly enhances the reliability, energy efficiency and end to end delay minimization. We also present architecture, message formats and different routing scenarios in this paper.

  12. Large-scale quality analysis of published ChIP-seq data.

    Science.gov (United States)

    Marinov, Georgi K; Kundaje, Anshul; Park, Peter J; Wold, Barbara J

    2014-02-19

    ChIP-seq has become the primary method for identifying in vivo protein-DNA interactions on a genome-wide scale, with nearly 800 publications involving the technique appearing in PubMed as of December 2012. Individually and in aggregate, these data are an important and information-rich resource. However, uncertainties about data quality confound their use by the wider research community. Recently, the Encyclopedia of DNA Elements (ENCODE) project developed and applied metrics to objectively measure ChIP-seq data quality. The ENCODE quality analysis was useful for flagging datasets for closer inspection, eliminating or replacing poor data, and for driving changes in experimental pipelines. There had been no similarly systematic quality analysis of the large and disparate body of published ChIP-seq profiles. Here, we report a uniform analysis of vertebrate transcription factor ChIP-seq datasets in the Gene Expression Omnibus (GEO) repository as of April 1, 2012. The majority (55%) of datasets scored as being highly successful, but a substantial minority (20%) were of apparently poor quality, and another ∼25% were of intermediate quality. We discuss how different uses of ChIP-seq data are affected by specific aspects of data quality, and we highlight exceptional instances for which the metric values should not be taken at face value. Unexpectedly, we discovered that a significant subset of control datasets (i.e., no immunoprecipitation and mock immunoprecipitation samples) display an enrichment structure similar to successful ChIP-seq data. This can, in turn, affect peak calling and data interpretation. Published datasets identified here as high-quality comprise a large group that users can draw on for large-scale integrated analysis. In the future, ChIP-seq quality assessment similar to that used here could guide experimentalists at early stages in a study, provide useful input in the publication process, and be used to stratify ChIP-seq data for different community

  13. A Review on the Generation and Control of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in High-Temperature Processed Meat Products%高温加工肉制品中PhIP的形成与控制

    Institute of Scientific and Technical Information of China (English)

    王南; 王桂瑛; 赵莹莹; 刘登勇

    2014-01-01

    PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is one of the most abundant heterocyclic amines detected in high-temperature cooked meat products. In this paper, the biological toxicity, formation mechanism, generation and control of PhIP are reviewed with the aim of providing a reference for related research.%2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶(PhIP)是肉制品在高温烹调加工过程中产生的含量较高的杂环胺类化合物。本文从PhIP的生物毒性、形成机制出发,探讨不同加工条件对其形成的影响,总结分析该物质的抑制措施,从而为相关研究提供参考。

  14. Dynamic Mobile IP routers in ad hoc networks

    NARCIS (Netherlands)

    Kock, B.A.; Schmidt, J.R.

    2005-01-01

    This paper describes a concept combining mobile IP and ad hoc routing to create a robust mobile network. In this network all nodes are mobile and globally and locally reachable under the same IP address. Essential for implementing this network are the dynamic mobile IP routers. They act as gateways

  15. A Survey of Voice over IP Security Research

    Science.gov (United States)

    Keromytis, Angelos D.

    We present a survey of Voice over IP security research. Our goal is to provide a roadmap for researchers seeking to understand existing capabilities and, and to identify gaps in addressing the numerous threats and vulnerabilities present in VoIP systems. We also briefly discuss the implications of our findings with respect to actual vulnerabilities reported in a variety VoIP products.

  16. Covert Channels in SIP for VoIP Signalling

    Science.gov (United States)

    Mazurczyk, Wojciech; Szczypiorski, Krzysztof

    In this paper, we evaluate available steganographic techniques for SIP (Session Initiation Protocol) that can be used for creating covert channels during signaling phase of VoIP (Voice over IP) call. Apart from characterizing existing steganographic methods we provide new insights by introducing new techniques. We also estimate amount of data that can be transferred in signalling messages for typical IP telephony call.

  17. A Conjoint Analysis of Voice Over IP Attributes.

    Science.gov (United States)

    Zubey, Michael L.; Wagner, William; Otto, James R.

    2002-01-01

    Managers need to understand the tradeoffs associated with voice over Internet protocol (VoIP) networks as compared to the Public Switched Telephone Network (PSTN). This article measures the preference structures between IP telephony and PSTN services using conjoint analysis. The purpose is to suggest VoIP technology attributes that best meet…

  18. Dynamic Mobile IP routers in ad hoc networks

    NARCIS (Netherlands)

    Kock, B.A.; Schmidt, J.R.

    2005-01-01

    This paper describes a concept combining mobile IP and ad hoc routing to create a robust mobile network. In this network all nodes are mobile and globally and locally reachable under the same IP address. Essential for implementing this network are the dynamic mobile IP routers. They act as gateways

  19. Covert Channels in SIP for VoIP signalling

    CERN Document Server

    Mazurczyk, Wojciech

    2008-01-01

    In this paper, we evaluate available steganographic techniques for SIP (Session Initiation Protocol) that can be used for creating covert channels during signaling phase of VoIP (Voice over IP) call. Apart from characterizing existing steganographic methods we provide new insights by introducing new techniques. We also estimate amount of data that can be transferred in signalling messages for typical IP telephony call.

  20. Impact of genome assembly status on ChIP-Seq and ChIP-PET data mapping

    Directory of Open Access Journals (Sweden)

    Sachs Laurent

    2009-12-01

    Full Text Available Abstract Background ChIP-Seq and ChIP-PET can potentially be used with any genome for genome wide profiling of protein-DNA interaction sites. Unfortunately, it is probable that most genome assemblies will never reach the quality of the human genome assembly. Therefore, it remains to be determined whether ChIP-Seq and ChIP-PET are practicable with genome sequences other than a few (e.g. human and mouse. Findings Here, we used in silico simulations to assess the impact of completeness or fragmentation of genome assemblies on ChIP-Seq and ChIP-PET data mapping. Conclusions Most currently published genome assemblies are suitable for mapping the short sequence tags produced by ChIP-Seq or ChIP-PET.

  1. Advances in methods of commercial FBR core characteristics analyses. Investigations of a treatment of the double-heterogeneity and a method to calculate homogenized control rod cross sections

    Energy Technology Data Exchange (ETDEWEB)

    Sugino, Kazuteru [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center; Iwai, Takehiko

    1998-07-01

    A standard data base for FBR core nuclear design is under development in order to improve the accuracy of FBR design calculation. As a part of the development, we investigated an improved treatment of double-heterogeneity and a method to calculate homogenized control rod cross sections in a commercial reactor geometry, for the betterment of the analytical accuracy of commercial FBR core characteristics. As an improvement in the treatment of double-heterogeneity, we derived a new method (the direct method) and compared both this and conventional methods with continuous energy Monte-Carlo calculations. In addition, we investigated the applicability of the reaction rate ratio preservation method as a advanced method to calculate homogenized control rod cross sections. The present studies gave the following information: (1) An improved treatment of double-heterogeneity: for criticality the conventional method showed good agreement with Monte-Carlo result within one sigma standard deviation; the direct method was consistent with conventional one. Preliminary evaluation of effects in core characteristics other than criticality showed that the effect of sodium void reactivity (coolant reactivity) due to the double-heterogeneity was large. (2) An advanced method to calculate homogenize control rod cross sections: for control rod worths the reaction rate ratio preservation method agreed with those produced by the calculations with the control rod heterogeneity included in the core geometry; in Monju control rod worth analysis, the present method overestimated control rod worths by 1 to 2% compared with the conventional method, but these differences were caused by more accurate model in the present method and it is considered that this method is more reliable than the conventional one. These two methods investigated in this study can be directly applied to core characteristics other than criticality or control rod worth. Thus it is concluded that these methods will

  2. Measuring Procrastination: Psychometric Properties of the Norwegian Versions of the Irrational Procrastination Scale (IPS) and the Pure Procrastination Scale (PPS)

    Science.gov (United States)

    Svartdal, Frode

    2017-01-01

    Procrastination has been defined in different ways. Two instruments--the Irrational Procrastination Scale (IPS) and the Pure Procrastination Scale (PPS)--focus on a core problem in procrastination--the irrational delay of intended behavior. The present paper examined the psychometric properties of the Norwegian translations of these scales. In…

  3. Measuring Procrastination: Psychometric Properties of the Norwegian Versions of the Irrational Procrastination Scale (IPS) and the Pure Procrastination Scale (PPS)

    Science.gov (United States)

    Svartdal, Frode

    2017-01-01

    Procrastination has been defined in different ways. Two instruments--the Irrational Procrastination Scale (IPS) and the Pure Procrastination Scale (PPS)--focus on a core problem in procrastination--the irrational delay of intended behavior. The present paper examined the psychometric properties of the Norwegian translations of these scales. In…

  4. Core y sistema de control neuro-motor: mecanismos básicos para la estabilidad del raquis lumbar

    Directory of Open Access Journals (Sweden)

    Víctor SEGARRA

    2014-09-01

    Full Text Available El "CORE" es un concepto funcional que engloba la integración de tres sistemas cuyo óptimo funcionamiento garantiza la realización de tareas con una mayor eficacia y seguridad a nivel raquídeo, permitiendo adecuados niveles de estabilidad y control del movimiento. En este sentido, a fin de afrontar con éxito retos que demanden un control dinámico de la columna y la pelvis, el SNC debe aplicar estrategias diferentes, sopesando as fuerzas internas y externas con el fin de proporcionar una respuesta muscular que permita un movimiento óptimo y resista cualquier posible perturbación. En el presente manuscrito se revisa de forma aplicada, las bases, atendiendo a la información disponible actualmente, de los mecanismos básicos de control motor y las posibles alteraciones en los mismos a ser considerados por los especialistas en ejercicio respecto a su intervención mediante programas de ejercicio para la mejora de la capacidad de estabilización raquídea.

  5. Thermal Performance of a Heat Pipe for Hybrid Control Rod in Advanced In-core Decay Heat Removal System

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyung Mo; Jeong, Yeong Shin; Bang, In Cheol [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)

    2014-05-15

    In this research, an innovative hybrid heat pipe system is designed for advanced in-core decay heat removal concept. Heat pipe is a device that transfer heat from pipe's hotter end to the colder end by phase change and convection of working fluid. The concept of the hybrid heat pipe system is that the control rod can have not only the original function of neutron absorber but also the function of the heat removal. If the function of heat pipe is applied to the control rods, the limited heat removal capacity can be extended because control rods are inserted to the reactor at initial state of accident using gravitational force. The neutron absorber-based heat pipe is designed to apply them to nuclear systems. However, thermosyphon and heat pipe are competitive as passive decay heat removal device in large scale. Thus, stainless steel 316L thermosyphon and heat pipe having sheath outer diameter of 3/4 inch (17.4 mm inner diameter), and the length of 1000 mm were tested. Effects on whether there is a wick structure on the heat pipe or not on the heat removal capacity were studied. To confirm the heat removal capacity of heat pipe, and heat transfer coefficient were measured for each specimen.

  6. SHEAR BOND STRENGTHS BETWEEN CERAMIC CORES AND VENEERING CERAMICS OF DENTAL BI-LAYERED CERAMIC SYSTEMS AND THE SENSITIVITY TO THERMOCYCLING

    Directory of Open Access Journals (Sweden)

    SUN TING, BDS, DDS

    2012-09-01

    Full Text Available The purpose of this study was to investigate the bond strength between various commercial ceramic core materials and veneering ceramics of dental bi-layered ceramic combinations and the effect of thermocycling. The shear bond strength of four dental bi-layered ceramic combinations (white Cercon, yellow Cercon, white Lava, yellow Lava, IPS E.max were tested. Metal ceramic combinations were conducted as a control group. Half of each group was subjected to thermocycling. All specimens were thereafter subjected to a shear force. The initial mean shear bond strength values in MPa ± S.D were 28.02 ± 3.04 for White Cercon Base/Cercon Ceram Kiss, 27.54 ± 2.20 for Yellow Cercon Base/Cercon Ceram Kiss, 28.43 ± 2.13for White Lava Frame/Lava Ceram, 27.36 ± 2.25 for Yellow Lava Frame/Lava Ceram, 47.10 ± 3.77 for IPS E.max Press/IPS E.max Ceram and 30.11 ± 2.15 for metal ceramic control. The highest shear strength was recorded for IPS E.max Press/IPS E.max Ceram before and after thermocycling. The mean shear bond strength values of five other combinations were not significantly different (P < 0.05. Lithium-disilicate based combinations produced the highest core-veneer bonds that overwhelmed the metal ceramic combinations. Thermocycling had no effect on the core-veneer bonds. The core-veneer bonds of zirconia based combinations were not weakened by the addition of coloring pigments.

  7. How can we integrate IP strategy with corporate strategy? Combining IP strategy with management strategy making process

    OpenAIRE

    田中, 義敏; Tanaka, Yoshitoshi

    2013-01-01

    Intellectual property systems have been introduced and used in manycountries as a global standard. However, its practical utilisation is still not yetmature because of the lack of IP strategy. Each enterprise has to define aunique IP strategy and be differentiated by other enterprises because the outsideenvironment and internal resource are different. IP people have to havebetter understandings on strategy making process, which is fundamental to themanagement field. In addition, IP strategy s...

  8. The balance of prickle/spiny-legs isoforms controls the amount of coupling between core and fat PCP systems.

    Science.gov (United States)

    Merkel, Matthias; Sagner, Andreas; Gruber, Franz Sebastian; Etournay, Raphael; Blasse, Corinna; Myers, Eugene; Eaton, Suzanne; Jülicher, Frank

    2014-09-22

    The conserved Fat and Core planar cell polarity (PCP) pathways work together to specify tissue-wide orientation of hairs and ridges in the Drosophila wing. Their components form intracellularly polarized complexes at adherens junctions that couple the polarity of adjacent cells and form global patterns. How Fat and Core PCP systems interact is not understood. Some studies suggest that Fat PCP directly orients patterns formed by Core PCP components. Others implicate oriented tissue remodeling in specifying Core PCP patterns. We use genetics, quantitative image analysis, and physical modeling to study Fat and Core PCP interactions during wing development. We show their patterns change during morphogenesis, undergoing phases of coupling and uncoupling that are regulated by antagonistic Core PCP protein isoforms Prickle and Spiny-legs. Evolving patterns of Core PCP are hysteretic: the early Core PCP pattern is modified by tissue flows and then by coupling to Fat PCP, producing sequential patterns that guide hairs and then ridges. Our data quantitatively account for altered hair and ridge polarity patterns in PCP mutants. Premature coupling between Fat and Core PCP explains altered polarity patterns in pk mutants. In other Core PCP mutants, hair polarity patterns are guided directly by Fat PCP. When both systems fail, hairs still align locally and obey signals associated with veins. Temporally regulated coupling between the Fat and Core PCP systems enables a single tissue to develop sequential polarity patterns that orient distinct morphological structures. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. IP Broadcasting Network Communications Security%浅谈 IP 广电网络的通信安全

    Institute of Scientific and Technical Information of China (English)

    吴永伟

    2015-01-01

    The IP digital broadcasting system is a fully digital audio-broadcasting system based on the IP net-works.Its physical structure completely syncretize with the IP networks,it breaks through the function limit of the traditional broadcasting.The IP digital broadcasting system has the security problems of communication,as it base on the IP networks.This paper discusses the security issues about the IP digital broadcasting system.%IP 数字广电网络是一套基于 IP 网络的纯数字化广播系统,基于 IP 网络的数字化广播、直播、点播,推送功能强大,灵活性强,并突破了传统模拟广播系统的局限性。但 IP 数字广电网络系统也继承了IP 网络安全的问题,主要分析 IP 广电网络所面对的安全问题,并提出解决方法。

  10. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in a...

  11. Proteomics Core

    Data.gov (United States)

    Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in...

  12. Analysis list: ATF7IP [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ATF7IP Epidermis + hg19 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF7IP....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ATF7IP.5.tsv http://dbarchive.biosciencedbc....jp/kyushu-u/hg19/target/ATF7IP.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ATF7IP.Epidermis.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/Epidermis.gml ...

  13. An attacker-defender model for IP-based networks

    OpenAIRE

    Barkley, Timothy R.

    2008-01-01

    The Internet Protocol (IP) has emerged as the dominant technology for determining how data is routed across the Internet. Because IP flows are defined essentially in terms of origin-destination (O-D) pairs, we represent IP traffic engineering as a multi-commodity flow problem in which each O-D pair is treated as a separate commodity. We account for the diversity in IP routing by modeling opposite extremes of traffic engineering: "naive" traffic engineering where the IP routes data between...

  14. Analysis list: Atf7ip [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Atf7ip Pluripotent stem cell + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Atf7ip....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Atf7ip.5.tsv http://dbarchive.biosc...iencedbc.jp/kyushu-u/mm9/target/Atf7ip.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Atf7ip.Plurip...otent_stem_cell.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Pluripotent_stem_cell.gml ...

  15. Linear Collider Test Facility: Twiss Parameter Analysis at the IP/Post-IP Location of the ATF2 Beam Line

    Energy Technology Data Exchange (ETDEWEB)

    Bolzon, Benoit; /Annecy, LAPP; Jeremie, Andrea; /Annecy, LAPP; Bai, Sha; /Beijing, Inst. High Energy Phys.; Bambade, Philip; /KEK, Tsukuba; White, Glen; /SLAC

    2012-07-02

    At the first stage of the ATF2 beam tuning, vertical beam size is usually bigger than 3 {micro}m at the IP. Beam waist measurements using wire scanners and a laser wire are usually performed to check the initial matching of the beam through to the IP. These measurements are described in this paper for the optics currently used ({beta}{sub x} = 4cm and {beta}{sub y} = 1mm). Software implemented in the control room to automate these measurements with integrated analysis is also described. Measurements showed that {beta} functions and emittances were within errors of measurements when no rematching and coupling corrections were done. However, it was observed that the waist in the horizontal (X) and vertical (Y) plane was abnormally shifted and simulations were performed to try to understand these shifts. They also showed that multiknobs are needed in the current optics to correct simultaneously {alpha}{sub x}, {alpha}{sub y} and the horizontal dispersion (D{sub x}). Such multiknobs were found and their linearity and orthogonality were successfully checked using MAD optics code. The software for these multiknobs was implemented in the control room and waist scan measurements using the {alpha}{sub y} knob were successfully performed.

  16. IP-I0 BASED IMMUNOLOGICAL MONITORING

    DEFF Research Database (Denmark)

    2008-01-01

    The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10.The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other...... suitable biological samples. The methods of the present invention are useful in therapeutic and diagnostic protocols for human, livestock and veterinary and wild life applications, thus the invention further relates to a method for diagnosing an infection in a mammal....

  17. Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: II. Effects on integrins and focal adhesions.

    Science.gov (United States)

    Tantivejkul, Kwanchanit; Vucenik, Ivana; Shamsuddin, Abulkalam M

    2003-01-01

    We have shown that inositol hexaphosphate (IP6), a natural compound and a potent anti-cancer agent, inhibited cancer cell adhesion to the extracellular matrix (ECM) proteins, thereby leading to inhibition of cell migration and invasion. Cell adhesion to ECM is mediated by specific cell surface integrins, which transduce intracellular signals through their interaction and activation of other proteins that are recruited to the focal adhesion. We hypothesize that IP6 decreases cell adhesion by suppressing the integrin receptors and their subsequent signaling pathway. We analyzed integrin expressions of the highly invasive estrogen receptor-negative human breast cancer MDA-MB 231 cells exposed to IP6 by flow cytometry. The expression of focal adhesion proteins was investigated by immunocytochemistry and Western blotting. IP6 treatment caused a significant (P IP6 treatment. When the expression of integrins on the cell surface was assessed, there was a dramatic 82% decrease in the expression of alpha 5 beta 1 on IP6-treated cells (P IP6, was used as a control. Immunocytochemistry showed a lack of clustering of paxillin; tyrosine-phosphorylated proteins in IP6-treated cells were discontinuous and scattered around the cell periphery, whereas the patterns were more dense and localized in control cells. Consistent with these observations, focal adhesion kinase (FAK) autophosphorylation at tyrosine-397 residue was suppressed, albeit modestly, by IP6 treatment, suggesting a down-regulation in the integrin-mediated signaling pathway. The results of this study indicate that IP6-induced inhibition of cancer cell adhesion, migration and invasion may be mediated through the modulation of integrin dimerization, cell surface expression and integrin-associated signaling pathway.

  18. Replacement of the human cytomegalovirus promoter with fish enhancer and core elements to control the expression of the G gene of viral haemorrhagic septicemia virus (VHSV).

    Science.gov (United States)

    Martinez-Lopez, A; Chinchilla, B; Encinas, P; Gomez-Casado, E; Estepa, A; Coll, J M

    2012-12-15

    This work explores some of the possibilities to replace human cytomegalovirus (CMV) core and/or enhancer promoter control elements to create new expression vectors for use with fish. The work is relevant to fish vaccination, since DNA vaccines use eukaryotic expression plasmids controlled by the human cytomegalovirus (CMV) promoter to be effective against novirhabdoviruses, such as viral haemorrhagic septicemia virus (VHSV), one of the most devastating fish viral European diseases. To reduce possible homologous recombination with fish genome, core and enhancer sequences from fish origin, such as trout interferon-inducible myxovirus protein (Mx), zebrafish retrovirus long terminal repeat (LTR) and carp β-actin (AE6), were combined with those of CMV to design alternative hybrid promoters. The substitution of CMV core and/or enhancer with the corresponding elements of Mx or the LTR core maintained a similar in vitro protein G expression level than that obtained by using the CMV promoter. Vectors using the dsRNA-inducible Mx enhancer followed either by the LTR or the AE6 cores showed the highest in vitro protein G expression levels. Furthermore, synthetic constructs using the Mx enhancer maintained their polyI:C induction capabilities despite the core used. Some of these hybrid promoters might contribute to the development of all-fish-vectors for DNA vaccines while others might be useful for more basic studies.

  19. Selective-Area MOCVD Growth and Carrier-Transport-Type Control of InAs(Sb)/GaSb Core-Shell Nanowires.

    Science.gov (United States)

    Ji, Xianghai; Yang, Xiaoguang; Du, Wenna; Pan, Huayong; Yang, Tao

    2016-12-14

    We report the first selective-area growth of high quality InAs(Sb)/GaSb core-shell nanowires on Si substrates using metal-organic chemical vapor deposition (MOCVD) without foreign catalysts. Transmission electron microscopy (TEM) analysis reveals that the overgrowth of the GaSb shell is highly uniform and coherent with the InAs(Sb) core without any misfit dislocations. To control the structural properties and reduce the planar defect density in the self-catalyzed InAs core nanowires, a trace amount of Sb was introduced during their growth. As the Sb content increases from 0 to 9.4%, the crystal structure of the nanowires changes from a mixed wurtzite (WZ)/zinc-blende (ZB) structure to a perfect ZB phase. Electrical measurements reveal that both the n-type InAsSb core and p-type GaSb shell can work as active carrier transport channels, and the transport type of core-shell nanowires can be tuned by the GaSb shell thickness and back-gate voltage. This study furthers our understanding of the Sb-induced crystal-phase control of nanowires. Furthermore, the high quality InAs(Sb)/GaSb core-shell nanowire arrays obtained here pave the foundation for the fabrication of the vertical nanowire-based devices on a large scale and for the study of fundamental quantum physics.

  20. Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data

    Directory of Open Access Journals (Sweden)

    Minucci Saverio

    2011-10-01

    Full Text Available Abstract Background High-throughput sequencing is generating massive amounts of data at a pace that largely exceeds the throughput of data analysis routines. Here we introduce Fish the ChIPs (FC, a computational pipeline aimed at a broad public of users and designed to perform complete ChIP-Seq data analysis of an unlimited number of samples, thus increasing throughput, reproducibility and saving time. Results Starting from short read sequences, FC performs the following steps: 1 quality controls, 2 alignment to a reference genome, 3 peak calling, 4 genomic annotation, 5 generation of raw signal tracks for visualization on the UCSC and IGV genome browsers. FC exploits some of the fastest and most effective tools today available. Installation on a Mac platform requires very basic computational skills while configuration and usage are supported by a user-friendly graphic user interface. Alternatively, FC can be compiled from the source code on any Unix machine and then run with the possibility of customizing each single parameter through a simple configuration text file that can be generated using a dedicated user-friendly web-form. Considering the execution time, FC can be run on a desktop machine, even though the use of a computer cluster is recommended for analyses of large batches of data. FC is perfectly suited to work with data coming from Illumina Solexa Genome Analyzers or ABI SOLiD and its usage can potentially be extended to any sequencing platform. Conclusions Compared to existing tools, FC has two main advantages that make it suitable for a broad range of users. First of all, it can be installed and run by wet biologists on a Mac machine. Besides it can handle an unlimited number of samples, being convenient for large analyses. In this context, computational biologists can increase reproducibility of their ChIP-Seq data analyses while saving time for downstream analyses. Reviewers This article was reviewed by Gavin Huttley, George

  1. Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering

    Directory of Open Access Journals (Sweden)

    Gaskon Ibarretxe

    2012-01-01

    Full Text Available The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The potential of IPS cell technology is tremendous, but it will be essential to improve the methodologies for IPS cell generation and to precisely evaluate each clone and subclone of IPS cells for their safety and efficacy. Additionally, the current state of knowledge on IPS cells advises that research on their regenerative properties is carried out in appropriate tissue and organ systems that permit a safe assessment of the long-term behavior of these reprogrammed cells. In the present paper, we discuss the mechanisms of cell reprogramming, current technical limitations of IPS cells for their use in human tissue engineering, and possibilities to overcome them in the particular case of dental regeneration.

  2. Interface control of electronic and optical properties in IV-VI and II-VI core/shell colloidal quantum dots: a review.

    Science.gov (United States)

    Jang, Youngjin; Shapiro, Arthur; Isarov, Maya; Rubin-Brusilovski, Anna; Safran, Aron; Budniak, Adam K; Horani, Faris; Dehnel, Joanna; Sashchiuk, Aldona; Lifshitz, Efrat

    2017-01-17

    Semiconductor colloidal quantum dots (CQDs) have attracted vast scientific and technological interest throughout the past three decades, due to the unique tuneability of their optoelectronic properties by variation of size and composition. However, the nanoscale size brings about a large surface-to-bulk volume ratio, where exterior surfaces have a pronounced influence on the chemical stability and on the physical properties of the semiconductor. Therefore, numerous approaches have been developed to gain efficient surface passivation, including a coverage by organic or inorganic molecular surfactants as well as the formation of core/shell heterostructures (a semiconductor core epitaxially covered by another semiconductor shell). This review focuses on special designs of core/shell heterostructures from the IV-VI and II-VI semiconductor compounds, and on synthetic approaches and characterization of the optical properties. Experimental observations revealed the formation of core/shell structures with type-I or quasi-type-II band alignment between the core and shell constituents. Theoretical calculations of the electronic band structures, which were also confirmed by experimental work, exposed surplus electronic tuning (beyond the radial diameter) with adaptation of the composition and control of the interface properties. The studies also considered strain effects that are created between two different semiconductors. It was disclosed experimentally and theoretically that the strain can be released via the formation of alloys at the core-shell interface. Overall, the core/shell and core/alloyed-shell heterostructures showed enhancement in luminescence quantum efficiency with respect to that of pure cores, extended lifetime, uniformity in size and in many cases good chemical sustainability under ambient conditions.

  3. Layer-by-Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties.

    Science.gov (United States)

    Polomska, Anna; Leroux, Jean-Christophe; Brambilla, Davide

    2017-01-01

    Layer-by-layer coating is a simple and versatile technique based on the sequential deposition of molecular species on planar surfaces or colloidal templates. Its relevance in drug delivery primarily emerges from its versatility to control the release rate of the cargo encapsulated within the colloidal core. The focus of this review is the layer-by-layer encapsulation of colloidal particles purely composed of drug, including the core fabrication step, coating materials and techniques, multilayer shell permeability control, and reported in vitro and in vivo outcomes.

  4. Performance Evaluation of IP Based Multimedia Services in UMTS

    Directory of Open Access Journals (Sweden)

    Riri Fitri SARI

    2008-01-01

    Full Text Available This paper presents our work in the performance evaluation of UMTS network based on simulation. Enhanced UMTS Radio Access Network Extensions for NS-2 (EURANE developed by SEACORN has brought us to the higher phase of UMTS simulation in third generation wireless telecommunication system. Wireless 3G is designed to be able to deliver various kind of multimedia package through an IP network for the purpose of easier interconnection with fixed network with various existing multimedia services. Multimedia services with their bandwidth consumption characteristics are able to be sent through a UMTS network with the existence of High Speed Data Packet Access (HSPDA in Release 5. Quality of Service (QoS is a major concern in multimedia services. This paper shows the performance analysis of a number of multimedia services and their QoS using HSDPA in UMTS. The experiments were based on EURANE extension for NS-2. From the simulation conducted, we found that Unacknowledged Mode (UM in Radio Link Control (RLC will perform better for QoS class number 1 (VoIP and 2 (Video Streaming, while Acknowledged Mode (AM mode are more suitable for QoS class number 3 (web server and 4 (FTP.

  5. Low latency IP mobility management: protocol and analysis

    Directory of Open Access Journals (Sweden)

    Guo Xiaobing

    2011-01-01

    Full Text Available Abstract Mobile IP is one of the dominating protocols that enable a mobile node to remain reachable while moving around in the Internet. However, it suffers from long handoff latency and route inefficiency. In this article, we present a novel distributed mobility management architecture, ADA (Asymmetric Double-Agents, which introduces double mobility agents to serve one end-to-end communication. One mobility agent is located close to the MN and the other close to the CN. ADA can achieve both low handoff latency and low transmission latency, which is crucial for improvement of user perceived QoS. It also provides an easy-to-use mechanism for MNs to manage and control each traffic session with a different policy and provide specific QoS support. We apply ADA to MIPv6 communications and present a detailed protocol design. Subsequently, we propose an analytical framework for systematic and thorough performance evaluation of mobile IP-based mobility management protocols. Equipped with this model, we analyze the handoff latency, single interaction delay and total time cost under the bidirectional tunneling mode and the route optimization mode for MIPv6, HMIPv6, CNLP, and ADA. Through both quantitative analysis and NS2-based simulations, we show that ADA significantly outperforms the existing mobility management protocols.

  6. Discovering Attack Path Oriented-IP Traceback

    Institute of Scientific and Technical Information of China (English)

    Fu Jianming(傅建明); Zhu Fuxi; Peng Guojun

    2003-01-01

    The technique of IP traceback may effectively block DOS (Denial Of Service) and meet the requirement of the computer forensic, but its accuracy depends upon that condition that each node in the Internet must support IP packet marking or detected agents. So far, this requirement is not satisfied. On the basis of traditional traceroute,this paper investigates the efficiency of discovering path methods from aspects of the size and order of detecting packets, and the length of paths.It points out that the size of padding in probed packets has a slight effect on discovering latency, and the latency with the method of bulk sending-receiving is much smaller than one with the traditional traceroute. Moreover, the loss rate of packets with the technique of TTL (Time To Live) which increases monotonously is less than that with the technique of TTL which decreases monotonously. Lastly,OS (Operating System) passive fingerprint is used as heuristic to predict the length of the discovered path so as to reduce disturbance in network traffic.

  7. Live Video and IP-TV

    Science.gov (United States)

    Merani, Maria Luisa; Saladino, Daniela

    This Chapter aims at providing a comprehensive insight into the most recent advances in the field of P2P architectures for video broadcasting, focusing on live video streaming P2P live video streaming . After introducing a classification of P2P video solutions, the first part of the Chapter provides an overview of the most interesting P2P IP-TV P2P IP-TV systems currently available over the Internet. It also concentrates on the process of data diffusion within the P2P overlay and complements this view with some measurements that highlight the most salient features of P2P architectures. The second part of the Chapter completes the view, bringing up the modeling efforts to capture the main characteristics and limits of P2P streaming systems, both analytically and numerically. The Chapter is closed by a pristine look at some challenging, open questions, with a specific emphasis on the adoption of network coding in P2P streaming solutions.

  8. IPS - a vision aided navigation system

    Science.gov (United States)

    Börner, Anko; Baumbach, Dirk; Buder, Maximilian; Choinowski, Andre; Ernst, Ines; Funk, Eugen; Grießbach, Denis; Schischmanow, Adrian; Wohlfeil, Jürgen; Zuev, Sergey

    2017-04-01

    Ego localization is an important prerequisite for several scientific, commercial, and statutory tasks. Only by knowing one's own position, can guidance be provided, inspections be executed, and autonomous vehicles be operated. Localization becomes challenging if satellite-based navigation systems are not available, or data quality is not sufficient. To overcome this problem, a team of the German Aerospace Center (DLR) developed a multi-sensor system based on the human head and its navigation sensors - the eyes and the vestibular system. This system is called integrated positioning system (IPS) and contains a stereo camera and an inertial measurement unit for determining an ego pose in six degrees of freedom in a local coordinate system. IPS is able to operate in real time and can be applied for indoor and outdoor scenarios without any external reference or prior knowledge. In this paper, the system and its key hardware and software components are introduced. The main issues during the development of such complex multi-sensor measurement systems are identified and discussed, and the performance of this technology is demonstrated. The developer team started from scratch and transfers this technology into a commercial product right now. The paper finishes with an outlook.

  9. Relationship between Interplanetary (IP) Parameters and Geomagnetic Indices during IP Shock Events of 2005

    Indian Academy of Sciences (India)

    Jatin Rathod; Girija Rajaram; Radharani Alyana; A. Chandrasekhar Reddy; D. S. Misra; C. G. Patil; M. Y. S. Prasad; A. G. Ananth

    2008-03-01

    In the present study, we investigate the possible relationship of IP parameters of solar wind and interplanetary magnetic field with ground-based geomagnetic indices. To carry out the study, we take all the IP shock events listed by Proton Monitor onboard Solar and Heliospheric Observatory (SOHO) during 2005, and plot the time variations of all the IP parameters and geomagnetic parameters (±5 days), centered at the shock arrival time. Next, we obtain scatter plots of absolute values of solar wind parameters such as Vsw, Nsw and Interplanetary Magnetic Field (IMF) components Bx, By, Bz and total B with the values of geomagnetic parameters such as Dst, Kp indices, dayside Magnetopause (MP) distance and Cosmic-Ray Neutron Monitor count (CRNM). The scatter plots show that before the IP shock, the pattern is random with no clear relationship. Following the shock, a clear pattern emerges with a type of relationship being seen – clear for SHARP shocks and less clear for DIFFUSE shocks. A total of 10 shock events for 2005 have been studied. Typical examples of this behaviour are the shock events of January 21, 2005 and May 15, 2005. Our study suggests a definite correlation between changes in the solar wind and interplanetary magnetic field parameters and ground-based geomagnetic response. We are trying to obtain quantitative relationships between these for shock events of 2005.

  10. Hyaluronidase enzyme core-5-fluorouracil-loaded chitosan-PEG-gelatin polymer nanocomposites as targeted and controlled drug delivery vehicles.

    Science.gov (United States)

    Rajan, M; Raj, V; Al-Arfaj, Abdullah A; Murugan, A M

    2013-09-10

    This study examines the performance of novel hyaluronidase enzyme core-5-fluorouracil-loaded chitosan-polyethylene glycol-gelatin polymer nanocomposites, which were prepared using an ionic gelation technique, as targeted and controlled drug delivery vehicles. These hyaluronidase-loaded nanoparticles have recently been proposed as targeted and controlled drug delivery vehicle systems to tissues due to their ability to loosen the intercellular connective matrix of hyaluronic acid. The encapsulation efficiency and loading capacities of the nanoparticles demonstrated that these nanocomposites displayed sufficient binding ability, which depends on the pH and initial concentration of the drug. The cytotoxic effects of the chitosan-hyaluronidase-5-fluorouracil (CS-HYL-5-FU), chitosan-hyaluronidase-5-fluorouracil polyethylene glycol (CS-HYL-5-FU-PEG), and chitosan-hyaluronidase-5-fluorouracil polyethylene glycol-gelatin (CS-HYL-5-FU-PEG-G) nanoparticles were assessed using MTT assays, and the nanovectors were found to be less cytotoxic than the chemotherapeutic 5-FU after incubation for 3-12h. The particle sizes of the CS-HYL-5-FU, CS-HYL-5-FU-PEG and CS-HYL-5-FU-PEG-G polymer composites were between 300 and 580 nm, as determined by a Zetasizer. Scanning electron microscopy (SEM) analysis indicated that the nanocomposites exhibit a clear, smooth surface and fine morphology. Linkages of the polymers, enzyme, and drug were confirmed by FTIR spectroscopy. Atomic fluorescence microscopy (AFM) analysis confirmed the size of the polymer composite nanoparticles. Therefore, this work established that the drug can be successfully encapsulated in chitosan-polyethylene glycol-gelatin-accompanied hyaluronidase nanoparticles with a homogeneous distribution. These nanoparticles can be potential carriers for targeted and controlled drug delivery to cancer cells.

  11. Chromatin immunoprecipitation (ChIP) of plant transcription factors followed by sequencing (ChIP-SEQ) or hybridization to whole genome arrays (ChIP-CHIP)

    NARCIS (Netherlands)

    Kaufmann, K.; Muiño, J.M.; Østerås, M.; Farinelli, L.; Krajewski, P.; Angenent, G.C.

    2010-01-01

    Chromatin immunoprecipitation (ChIP) is a powerful technique to study interactions between transcription factors (TFs) and DNA in vivo. For genome-wide de novo discovery of TF-binding sites, the DNA that is obtained in ChIP experiments needs to be processed for sequence identification. The sequences

  12. In vitro synthesis and purification of PhIP-deoxyguanosine and PhIP-DNA oligomer covalent complexes

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, J.

    1994-12-01

    2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic amine compound formed when meats are cooked at high temperatures. PhIP damages DNA by forming covalent complexes with DNA carcinogen. In an effort to understand how the binding of PhIP to DNA may cause cancer, it is important to characterize the structures of PhIP-damaged DNA molecules. Our HPLC data support fluorescence and {sup 32}P Post-labeling studies which indicate the formation of several species of 2{prime}deoxyguanosine-(dG) or oligodeoxynucleotide-PhIP adducts. The reaction of PhIP with dG resulted in a reddish precipitate that was likely the major adduct, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-PhIP) adduct, with a more polar adduct fraction remaining in the supernatant. Reversed-phase HPLC analysis of the adducts in the supernatant revealed the existence of species of much shorter retention times than the dG-C8-PhIP adduct, confirming that these species are more polar than dG-C8-PhIP. At least four adducts were formed in the reaction of PhIP with DNA oligomer. HPLC analysis of the PhIP-DNA oligomer supernatant after butanol extractions revealed four unresolved peaks which spectra had maximum wavelengths between 340 and 360 nm. Though adduct peaks were not completely resolved, there was {approximately}3 minutes interval between the DNA oligomer peak and the adduct peaks. Furthermore, fluorescence emission data of the DNA oligomer-PhIP adduct solution show heterogeneous binding. The more polar PhIP adducts were fraction-collected and their structures will be solved by nuclear magnetic resonance or x-ray crystallography.

  13. Macrocell Builder: IP-Block-Based Design Environment for High-Throughput VLSI Dedicated Digital Signal Processing Systems

    Directory of Open Access Journals (Sweden)

    Urard Pascal

    2006-01-01

    Full Text Available We propose an efficient IP-block-based design environment for high-throughput VLSI systems. The flow generates SystemC register-transfer-level (RTL architecture, starting from a Matlab functional model described as a netlist of functional IP. The refinement model inserts automatically control structures to manage delays induced by the use of RTL IPs. It also inserts a control structure to coordinate the execution of parallel clocked IP. The delays may be managed by registers or by counters included in the control structure. The flow has been used successfully in three real-world DSP systems. The experimentations show that the approach can produce efficient RTL architecture and allows to save huge amount of time.

  14. Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli.

    Directory of Open Access Journals (Sweden)

    Kirstie Canene-Adams

    Full Text Available The heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-B]pyridine (PhIP, found in meats cooked at high temperatures, has been implicated in epidemiological and rodent studies for causing breast, prostate, and colorectal cancers. A previous animal study using a xenograft model has shown that whole tomato and broccoli, when eaten in combination, exhibit a marked effect on tumor reduction compared to when eaten alone. Our aim was to determine if PhIP-induced carcinogenesis can be prevented by dietary consumption of whole tomato + broccoli powders. Male Fischer 344 rats (n = 45 were randomized into the following treatment groups: control (AIN93G diet, PhIP (200 ppm in AIN93G diet for the first 20 weeks of the study, or tomato + broccoli + PhIP (mixed in AIN93G diet at 10% each and fed with PhIP for 20 weeks, and then without PhIP for 32 weeks. Study animals were monitored for 52 weeks and were euthanized as necessary based on a set of criteria for health status and tumor burden. Although there appeared to be some hepatic and intestinal toxicity due to the combination of PhIP and tomato + broccoli, these rodents had improved survival and reduced incidence and/or severity of PhIP-induced neoplastic lesions compared to the PhIP-alone treated group. Rats eating tomato + broccoli exhibited a marked decrease in the number and size of cribiform prostatic intraepitheilial neoplasia/carcinoma in situ (cribiform PIN/CIS lesions and in the incidence of invasive intestinal adenocarcinomas and skin carcinomas. Although the apparent toxic effects of combined PhIP and tomato + broccoli need additional study, the results of this study support the hypothesis that a diet rich in tomato and broccoli can reduce or prevent dietary carcinogen-induced cancers.

  15. Effectiveness of core stability exercises and recovery myofascial release massage on fatigue in breast cancer survivors: a randomized controlled clinical trial.

    Science.gov (United States)

    Cantarero-Villanueva, Irene; Fernández-Lao, Carolina; Del Moral-Avila, Rosario; Fernández-de-Las-Peñas, César; Feriche-Fernández-Castanys, María Belén; Arroyo-Morales, Manuel

    2012-01-01

    The purpose of the present paper was to evaluate the effects of an 8-week multimodal program focused on core stability exercises and recovery massage with DVD support for a 6-month period in physical and psychological outcomes in breast cancer survivors. A randomized controlled clinical trial was performed. Seventy-eight (n = 78) breast cancer survivors were assigned to experimental (core stability exercises plus massage-myofascial release) and control (usual health care) groups. The intervention period was 8 weeks. Mood state, fatigue, trunk curl endurance, and leg strength were determined at baseline, after the last treatment session, and at 6 months of followup. Immediately after treatment and at 6 months, fatigue, mood state, trunk curl endurance, and leg strength exhibited greater improvement within the experimental group compared to placebo group. This paper showed that a multimodal program focused on core stability exercises and massage reduced fatigue, tension, depression, and improved vigor and muscle strength after intervention and 6 months after discharge.

  16. The ATWS analysis of one control rod withdraw out of the HTR-10GT core in addition with bypass valve failure

    Energy Technology Data Exchange (ETDEWEB)

    Lang, Minggang, E-mail: langmg@tsinghua.edu.cn [Institute of Nuclear and New Energy Technology, Tsinghua University, Room 207, Building B, Nengkelou, Beijing (China); Dong, Yujie [Institute of Nuclear and New Energy Technology, Tsinghua University, Room 503, Building A, Nengkelou, Beijing (China)

    2014-05-01

    The 10 MW high temperature gas cooled test reactor (HTR-10) has been built in Institute of Nuclear and New Energy Technology (INET) and has been operating successfully since the beginning of 2003. The core outlet temperature of HTR-10 is 700 °C. To verify the technology of gas-turbine direct cycle, at first INET had a plan to increase its core outlet temperature to 750 °C and use a helium gas turbine instead of the steam generator (then the reactor is called HTR-10GT). Though HTR-10 has good intrinsic safety, the design basic accidents and beyond design basic accidents of HTR10-GT must be analyzed according to China's nuclear regulations due to changed operation parameters. THERMIX code system is used to study the ATWS accident of one control rod withdrawal out of the core by a mistake. After a control rod in the side reflector was withdrawn out at a speed of 1 cm/s by a mistake, a positive reactivity was inserted and the reactor power increased and the temperature of the core increased. When the neutron flux of power measuring range exceeded 123% and the core outlet temperature was greater than 800 °C, the reactor should scram. It was supposed that all the control rods in the reflectors had been blocked and the reactor could not scram. Thus the accident went on and the core temperature and the system pressure increased but the reactor shutdown at last because of its natural negative temperature reactivity feedback mechanism, in spite of the failure of bypass valve. The residual heat would be removed out of the core by the cavity cooling system. During the accident sequence the maximum fuel temperature was 1283.3 °C. It was a litter than 1230 °C – the fuel temperature limitation of HTR-10. Now the sphere fuel used in HTR-10GT will also be used in HTR-PM and the temperature limitation will be raised to 1620 °C, so the HTR-10GT is safe during the ATWS of one control rod withdrawal out of the core. The paper also compares the analysis result of HTR10-GT

  17. Core 2 ß1,6-N-acetylglucosaminyltransferase-I, crucial for P-selectin ligand expression is controlled by a distal enhancer regulated by STAT4 and T-bet in CD4+ T helper cells 1.

    Science.gov (United States)

    Mardahl, Maibritt; Schröter, Micha F; Engelbert, Dirk; Pink, Matthias; Sperandio, Markus; Hamann, Alf; Syrbe, Uta

    2016-09-01

    P-selectin ligands (P-ligs) support the recruitment of lymphocytes into inflamed tissues. Binding to P-selectin is mediated by oligosaccharide groups synthesized by means of several glycosyltransferases including core 2 ß1,6-N-acetylglucosaminyltransferase-I (C2GlcNAcT-I), encoded by the gene Gcnt1. Using Gcnt1(-/-) Th1 cells, we show that C2GlcNAcT-I is crucial for inflammatory T cell homing in vivo. To understand the molecular regulation of Gcnt1 in CD4(+) T helper cells, we performed ChIP-on-chip experiments across the Gcnt1 locus assessing the chromatin structure in P-lig-expressing versus non-expressing CD4(+) T cells. This identified a distal region about 20kb upstream of the promoter where the presence of a H3K27me3 mark correlated with Gcnt1 repression. This region possessed IL-12-dependent enhancer activity in reporter assays, in accordance with preferential IL-12-dependent induction of Gcnt1 in vitro. STAT4 and T-bet cooperated in control of the enhancer activity. Deficiency in either one resulted in drastically reduced Gcnt1 mRNA expression in differentiated Th1 cells. While both STAT4 and T-bet were bound to the enhancer early after activation only T-bet binding persisted throughout the expansion phase after TCR signal cessation. This suggests sequential action of STAT4 and T-bet at the enhancer. In summary, we show that Gcnt1 transcription and subsequent P-lig induction in Th1 cells is governed by binding of STAT4 and T-bet to a distal enhancer and further regulated by epigenetic marks such as H3K27me3.

  18. Yolk/Shell Colloidal Crystals Incorporating Movable Cores with Their Motion Controlled by an External Electric Field

    NARCIS (Netherlands)

    K., Watanabe,; H., Ishii,; Konno, M.; Imhof, A.; van Blaaderen, A.; Nagao, D.

    2016-01-01

    Yolk/shell particles composed of a submicrometer-sized movable core and a silica shell are promising building blocks for novel optical colloidal crystals, because the locations of cores in the shell compartment can be reversibly changed by using external stimuli. Two dimensional arrays of yolk/shell

  19. Dynamically controlled one-pot synthesis of heterogeneous core-shell MOF single crystals using guest molecules.

    Science.gov (United States)

    Wang, Lei; Yang, Weiting; Li, Yangxue; Xie, Zhigang; Zhu, Wei; Sun, Zhong-Ming

    2014-10-11

    A new mixed guest approach for the synthesis of heterogeneous core-shell MOF crystals was exemplified by one-pot assembly of photoactive guests into an anionic host framework. The formation mechanism, photophysical properties and oxygen gas sensing properties of as-synthesized core-shell MOF crystals were also investigated.

  20. KAJIAN INDUCED PLURIPOTENT STEMCELL (iPS (HARAPAN DAN TANTANGAN

    Directory of Open Access Journals (Sweden)

    Masagus Zainuri

    2014-05-01

    Full Text Available AbstractInduced Pluripotent Stemcell (iPS are adult cells which the genetic information in the nucleus of those cells being reprogrammed (reprogram by inserting exogenous pluripotential genes. The exogenous gene transduction is using vectors, such as lentivirus, retrovirus, or adenovirus, which suppressed the gene expression of the original cells, so they will express the transduced exogenous gene. Viral vectors are then used to reprogramming and producing iPS clones that are pluripotent. iPS derived from adult cells of patient with certain diseases will be used as a tool to study the mechanisms of those specific diseases and the effects of selected drugs against the diseases. Several previous studies have shown that iPS clones developed from specific genetic disease have its original genotype and retain the character of the response to the drug that similar as the original adult cells. Opportunities for the utilization of autologous iPS cell therapy in the future is wide open as expected iPS transplant will not be rejected when transplanted back to the patient. Behind all its potential, iPS production is still facing some problems to be applicable clinically. The use of viruses as vectors may cause problems due to virus gene sequences may be integrated into the genome of the DNA donor cell, thereby causing mutations of the iPS clones. Several subsequent studies have succeeded in replacing the use of viruses as vectors, but the level of efficiency obtained is still very low. Another problem that arises is that epigenetic changes may occur in iPS cultures. Many advanced research related to iPS may be developed in Indonesia and is necessary to improve the production efficiency of iPS and solve iPS clones epigenetic changes problems in the future.Keywords: iPS, pluripotency, transduction, transfection.AbstrakInduced Pluripotent Stemcell (iPS adalah sel somatic dewasa yang informasi genetika dalam inti selnyadiprogram ulang (reprogram dengan cara

  1. Buffer Planning for IP Placement Using Sliced-LFF

    Directory of Open Access Journals (Sweden)

    Ou He

    2011-01-01

    Full Text Available IP cores are widely used in modern SOC designs. Hierarchical design has been employed for the growing design complexity, which stimulates the need for fixed-outline floorplanning. Meanwhile, buffer insertion is usually adopted to meet the timing requirement. In this paper, buffer insertion is considered with a fixed-outline constraint using Less Flexibility First (LFF algorithm. Compared with Simulated Annealing (SA, our work is able to distinguish geometric differences between two floorplan candidates, even if they have the same topological structure. This is helpful to get a better result for buffer planning since buffer insertion is quite sensitive to a geometric change. We also extend the previous LFF to a more robust version called Sliced-LFF to improve buffer planning. Moreover, a 2-staged LFF framework and a post-greedy procedure are introduced based on our net-classing strategy and finally achieve a significant improvement on the success rate of buffer insertion (40.7% and 37.1% in different feature sizes. Moreover, our work is much faster than SA, since it is deterministic without iterations.

  2. 解密家用VoIP

    Institute of Scientific and Technical Information of China (English)

    陈荆花

    2006-01-01

    对一个计算机从业者,人们经常期望他了解所有VoIP技术——如同期望他能恢复硬盘、杀除病毒、组建家庭网络、让用不同语言写的程序兼容运行等等。而事实上,尽管一位计算机从业者可能读过许多行业杂志,或在实验室研究过Asterisk(开放源代码的软件VoIP PBX系统)和SIP网关之类的东西,但真正要在家庭动手实践时,那些理论不一定能解决问题。

  3. Molecular double core-hole electron spectroscopy for chemical analysis

    CERN Document Server

    Tashiro, Motomichi; Fukuzawa, Hironobu; Ueda, Kiyoshi; Buth, Christian; Kryzhevoi, Nikolai V; Cederbaum, Lorenz S

    2010-01-01

    We explore the potential of double core hole electron spectroscopy for chemical analysis in terms of x-ray two-photon photoelectron spectroscopy (XTPPS). The creation of deep single and double core vacancies induces significant reorganization of valence electrons. The corresponding relaxation energies and the interatomic relaxation energies are evaluated by CASSCF calculations. We propose a method how to experimentally extract these quantities by the measurement of single and double core-hole ionization potentials (IPs and DIPs). The influence of the chemical environment on these DIPs is also discussed for states with two holes at the same atomic site and states with two holes at two different atomic sites. Electron density difference between the ground and double core-hole states clearly shows the relaxations accompanying the double core-hole ionization. The effect is also compared with the sensitivity of single core hole ionization potentials (IPs) arising in single core hole electron spectroscopy. We have ...

  4. Removal of Cr(VIin water by Fe3O4/IP6

    Directory of Open Access Journals (Sweden)

    CHEN Lu

    2014-12-01

    Full Text Available The preparation of functional ferroferric oxide (Fe3O4 magnetic nanoparticles is widely concerned.However,during their preparation,it is difficult to control the morphology of Fe3O4 nanoparticles and also a serious agglomeration exists,greatly restricting their applications.In present paper,an economical and ′green′ reagent-phytic acid (IP6 can form micelle in the water and then the nanoparticles can grow in a soft template.The as-prepared Fe3O4/IP6 exhibited a good stability and high dispersion.Fe3O4/IP6 can chelate with Cr (VI due to its phosphate structure.The Fe3O4/IP6 chelated with Cr (VI can be removed conveniently from water using an external magnet.Fe3O4/IP6 nanocomposites have a good adsorption capacity to Cr (VI within a short time (10 min.Additionally,the effect of pH on adsorption efficiency was studied.

  5. Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of TB

    DEFF Research Database (Denmark)

    Ruhwald, Morten; Bodmer, T; Maier, C

    2008-01-01

    were obtained from 80 patients with culture and/or PCR proven TB, and 124 unexposed healthy controls; 86 high school students and 38 high school staff. IP-10 and MCP-2 test cut-offs were established based on ROC curve analysis.TB patients produced significantly higher levels of IP-10 (median 2158 pg.......ml(-1)) and MCP-2 (median 379 pg.ml(-1)) compared with IFN-gamma (median 215 pg.ml(-1), pTB patients; 0%, 3% and 0% of the high school students and 0%, 16%; and 3% of the staff. Agreement between tests was high >89% (kappa>0.......77). By combining IP-10 and IFN-gamma tests the detection rate increased among TB patients to 90% without a significant increase in positive responders among the students.In conclusion, IP-10 and MCP-2 responses to M.tuberculosis specific antigens could be used to diagnose infection. Combining IP-10 and IFN...

  6. The Effectiveness of IPS-based Contextual Learning to Improve Students Character

    Directory of Open Access Journals (Sweden)

    Warsito Warsito

    2017-08-01

    Full Text Available This research aims to 1 find the reasons so that the learning of contextual-based IPS is effective to increase the student's character, 2 describes the effectiveness of IPS-based contextual learning to improve students ' character, 3 compare the effectiveness of IPS-based contextual learning with learning conventional IPS in an attempt to improve the character of students. This research uses qualitative and quantitative paradigms (mixed methods. The population in this research is grade VIII SMP Negeri in Surakarta (solo and Boyolali district in Sukoharjo, Karanganyar, Wonogiri, Sragen, Klaten and. Total sample overall as much as 828 students incorporated in 26 classes, classes of experimental group 13 (414 students and 13 classes of control group (414 students. Data collection technique using the test, questionnaire, interview, observation, and documentation. Data analysis techniques with different test that begins with a test of its homogeneity and normality test. How to CiteWarsito, W., Asrowi, A., Mulyoto, M. & Anitah, S. (2016. The Effectiveness of IPS-based Contextual Learning to Improve Students Character. International Journal of Active Learning, 1(1. 

  7. Pressurisation of IP-SOFC technology for second generation hybrid application

    Energy Technology Data Exchange (ETDEWEB)

    Jones, L.

    2005-07-01

    The Integrated Planar Solid Oxide Fuel Cell (IP-SOFC) technology developed by Rolls-Royce plc is a hybrid fuel cell technology considered highly suitable for the distributed power generation market. This report presents the results of a project to examine the technical viability of the IP-SOFC technology and some of the associated hybrid system component technologies under pressurised conditions and to investigate the validity of the predicted pressurisation phenomena. The work included: identification of critical material specifications, construction processes, control parameters, etc; the design and commissioning of two pressurised IP-SOFC test rigs at Rolls Royce in Derby; testing two multi-bundle strips at high temperature and atmospheric pressure; testing an active IP-SOFC bundle at high temperature and pressure; testing an experimental steam reforming unit at high temperature and pressure; testing a novel low pressure drop, off-gas combustor concept under atmospheric and pressurised conditions; design studies to identify key parameters affecting the successful integration and packaging of the fuel cell stack with certain associated hybrid components; and designing a hybrid system experimental verification rig. Significant progress was made in addressing the development challenges associated with the IP-SOFC of leakage, performance, durability, yield and geometry, the reaction rate of steam reforming and emissions from the off-gas combustor. Recommendations for future work are made.

  8. Implementation of a Prototype VoIP System

    Institute of Scientific and Technical Information of China (English)

    刘喜成; 李仲同

    2000-01-01

    VoIP (Voice over IP) is a rapidly growing area with great market potential. To promote it for both commercial and research purposes, a prototype VoIP system based on state-of-the-art Motorola communication techniques has been developed. It is a gateway system integrating a PBX and a VoIP module. All com ponents that H.323 defines to support VoIP are implemented in the VoIP module, though in a simplified manner. As an embedded system, the system features real timeness and task distributiveness. A number of additional techniques are used to improve the performance, including noise suppression, zero copy, and buffer structure optimization. When refined in interoperability, the system will also readily serve as a product.

  9. CXCL10/IP10 is a novel potential in vitro marker of TB infection

    Directory of Open Access Journals (Sweden)

    Ilaria Sauzullo

    2009-06-01

    Full Text Available Introduction IFN-γ is a pivotal cytokine in the immune response to Myc. tuberculosis, infact this is the key cytokine produced in response to antigens specific following tuberculosis exposure causing either active or latent tuberculosis (TB and this observation forms the basis of interferon gamma release assay (IGRA, but there are alternative or additional cytokines and chemokines that could be used to improve detection of Myc. tuberculosis infection.The aim of this study was to evaluate the diagnostic utility of chemokine CXCL10/IP-10 as biomarker of active TB and to compare the results with classical QuantiFERON-Gold assay . Methods CXCL10/IP-10 and IFN-γ responses to stimulation with ESAT-6 and CFP-10 were evaluated in 21 patients with active tuberculosis and in 6 healthy unexposed subjects with no history of TB or TB contact were used as controls healthy controls. QuantiFERON-TB Gold (QFT-G, Cellestis was used for the measurement of IFN-γ levels; CXCL10/IP-10 was detected by ELISA (R&D Systems . Results Of the 21 TB patients included, 11 had a QFT-G positive and 10 had negative QFT-G results.All QFT-G positive patients had increased levels of CXCL10/IP-10 (median, pg/ml in both ESAT-6 and CFP-10 stimulated samples patients compared to healthy controls (1807 and 1111 vs 251 and 188 of controls, respectively (p<0.001 for both. The patients with active TB and QFT-G negative exhibited higher concentrations of CXCL10/IP-10 following antigen stimulation (837 pg/ml for ESAT-6;1674 pg/ml for CFP-10 (p<0.001. Conclusion Our study showed that in all patients with active TB, the CXCL10/IP-10 is expressed in higher amounts than IFN-γ following Myc. tuberculosis antigen-specific stimulation, and CXCL10/IP-10 appeared to be even more sensitive than QuantiFERON TB-Gold in TB patients with negative IFN-γ response. The measurement of chemokine CXCL10/IP-10, although not specific for tuberculosis, may have potential as an alternative or additional marker

  10. BRCA1 Accelerates CtIP-Mediated DNA-End Resection

    Directory of Open Access Journals (Sweden)

    Andrés Cruz-García

    2014-10-01

    Full Text Available DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein interactions, including cell-cycle-controlled interaction with BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher eukaryotes at high resolution. We demonstrate that the BRCA1-CtIP interaction, albeit not essential for resection, modulates the speed at which this process takes place.

  11. Global path and bandwidth scheduling in inter-data-center IP/optical transport network

    Science.gov (United States)

    Zhao, Yang; Wang, Lei; Chen, Xue; Yang, Futao; Shi, Sheping; Wang, Huitao

    2016-07-01

    We propose a flow-oriented global path and bandwidth scheduling scheme for inter-data-center IP/optical network. To improve the throughput of network and reduce the mutual impact between flows, we allow each flow to be carried by a multi-path optical channel data unit (ODU) channel. In addition bandwidth is allocated to flows fairly according to weight. Simulation results reveal that compared to high-priority-first mechanism, the method proposed improves average bandwidth allocation ratio by about 15% and allocation fairness between flows by 30%. Furthermore, compared to pure IP network, router ports are significantly saved and network cost can be reduced by up to 40% with scheme proposed in unified controlled IP/optical network.

  12. IP Telephony Interconnection Reference Challenges, Models, and Engineering

    CERN Document Server

    Boucadair, Mohamed; Neves, Pedro Miguel; Einarsson, Olafur Pall

    2011-01-01

    Addressing the growth of IP telephony service offerings within the corporate and residential realm, IP Telephony Interconnection Reference: Challenges, Models, and Engineering examines the technical and regulatory issues related to IP telephony interconnection at the large scale. It describes business and interconnection models, reviews emerging architectures such as IMS and TISPAN, identifies commonly-encountered issues, and supplies solutions to technical issues. The authors offer a detailed overview of SPEERMINT activity and proposed architecture, the current work undertaken in i3 Forum, an

  13. ATF2 Ultra-Low IP Betas Proposal

    CERN Document Server

    Bambade, P; Bai, S; Braun, H; Delahaye, J P; Marin, E; Schulte, D; Tomás, R; Zimmermann, F; Gao, J; Wang, D; Zhu, XW; Honda, Y; Kuroda, S; Okugi, T; Tauchi, T; Terunuma, N; Urakawa, J; Seryi, A; White, G; Woodley, M; Angal-Kalinin, D; Jones, J; Scarfe, A

    2010-01-01

    The CLIC Final Focus System has considerably larger chromaticity than those of ILC and its scaled test machine ATF2. We propose to reduce the IP betas of ATF2 to reach a CLIC-like chromaticity. This would also allow to study the FFS tuning difficulty as function of the IP beam spot size. Both the ILC and CLIC projects will largely benefit from the ATF2 experience at these ultra-low IP betas.

  14. Mobility and QoS Support in Mobile IP Networks

    Institute of Scientific and Technical Information of China (English)

    DUAN Lian; WU Wei-ling

    2004-01-01

    This paper presents the state of the art of the Quality of Service (QoS) and mobility support mechanisms for mobile IP networks, which includes the issues and challenges in QoS support, an overview of the Mobile IP protocol, a general description of the QoS and Mobility framework, and the End-To-End QoS architecture in the next-generation all-IP mobile network.

  15. ChIP-seq Identification of Weakly Conserved Heart Enhancers

    Energy Technology Data Exchange (ETDEWEB)

    Blow, Matthew J.; McCulley, David J.; Li, Zirong; Zhang, Tao; Akiyama, Jennifer A.; Holt, Amy; Plajzer-Frick, Ingrid; Shoukry, Malak; Wright, Crystal; Chen, Feng; Afzal, Veena; Bristow, James; Ren, Bing; Black, Brian L.; Rubin, Edward M.; Visel, Axel; Pennacchio, Len A.

    2010-07-01

    Accurate control of tissue-specific gene expression plays a pivotal role in heart development, but few cardiac transcriptional enhancers have thus far been identified. Extreme non-coding sequence conservation successfully predicts enhancers active in many tissues, but fails to identify substantial numbers of heart enhancers. Here we used ChIP-seq with the enhancer-associated protein p300 from mouse embryonic day 11.5 heart tissue to identify over three thousand candidate heart enhancers genome-wide. Compared to other tissues studied at this time-point, most candidate heart enhancers are less deeply conserved in vertebrate evolution. Nevertheless, the testing of 130 candidate regions in a transgenic mouse assay revealed that most of them reproducibly function as enhancers active in the heart, irrespective of their degree of evolutionary constraint. These results provide evidence for a large population of poorly conserved heart enhancers and suggest that the evolutionary constraint of embryonic enhancers can vary depending on tissue type.

  16. Electrostatically assisted fabrication of silver-dielectric core/shell nanoparticles thin film capacitor with uniform metal nanoparticle distribution and controlled spacing.

    Science.gov (United States)

    Li, Xue; Niitsoo, Olivia; Couzis, Alexander

    2016-03-01

    An electrostatically-assisted strategy for fabrication of thin film composite capacitors with controllable dielectric constant (k) has been developed. The capacitor is composed of metal-dielectric core/shell nanoparticle (silver/silica, Ag@SiO2) multilayer films, and a backfilling polymer. Compared with the simple metal particle-polymer mixtures where the metal nanoparticles (NP) are randomly dispersed in the polymer matrix, the metal volume fraction in our capacitor was significantly increased, owing to the densely packed NP multilayers formed by the electrostatically assisted assembly process. Moreover, the insulating layer of silica shell provides a potential barrier that reduces the tunneling current between neighboring Ag cores, endowing the core/shell nanocomposites with a stable and relatively high dielectric constant (k) and low dielectric loss (D). Our work also shows that the thickness of the SiO2 shell plays a dominant role in controlling the dielectric properties of the nanocomposites. Control over metal NP separation distance was realized not only by variation the shell thickness of the core/shell NPs but also by introducing a high k nanoparticle, barium strontium titanate (BST) of relatively smaller size (∼8nm) compared to 80-160nm of the core/shell Ag@SiO2 NPs. The BST assemble between the Ag@SiO2 and fill the void space between the closely packed core/shell NPs leading to significant enhancement of the dielectric constant. This electrostatically assisted assembly method is promising for generating multilayer films of a large variety of NPs over large areas at low cost.

  17. Securing TCP/IP and Dial-up Access to Administrative Data.

    Science.gov (United States)

    Conrad, L. Dean

    1992-01-01

    This article describes Arizona State University's solution to security risk inherent in general access systems such as TCP/IP (Transmission Control Protocol/INTERNET Protocol). Advantages and disadvantages of various options are compared, and the process of selecting a log-on authentication approach involving generation of a different password at…

  18. IndigoVision IP video keeps watch over remote gas facilities in Amazon rainforest

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-07-15

    In Brazil, IndigoVision's complete IP video security technology is being used to remotely monitor automated gas facilities in the Amazon rainforest. Twelve compounds containing millions of dollars of process automation, telemetry, and telecom equipment are spread across many thousands of miles of forest and centrally monitored in Rio de Janeiro using Control Center, the company's Security Management software. The security surveillance project uses a hybrid IP network comprising satellite, fibre optic, and wireless links. In addition to advanced compression technology and bandwidth tuning tools, the IP video system uses Activity Controlled Framerate (ACF), which controls the frame rate of the camera video stream based on the amount of motion in a scene. In the absence of activity, the video is streamed at a minimum framerate, but the moment activity is detected the framerate jumps to the configured maximum. This significantly reduces the amount of bandwidth needed. At each remote facility, fixed analog cameras are connected to transmitter nodules that convert the feed to high-quality digital video for transmission over the IP network. The system also integrates alarms with video surveillance. PIR intruder detectors are connected to the system via digital inputs on the transmitters. Advanced alarm-handling features in the Control Center software process the PIR detector alarms and alert operators to potential intrusions. This improves operator efficiency and incident response. 1 fig.

  19. Broadband IP Stream Transmission Experiments over Global and Long Distance Networks

    Institute of Scientific and Technical Information of China (English)

    Kimio; Oguchi; Tetsuro; Fujii; Atsushi; Takahara; Toshiaki; Miyazaki; Kazuo; Hagimoto; Sadayasu; Ono

    2003-01-01

    Super High Definition (SHD) movies were successfully transmitted as streaming contents at about 300 Mbps for the first time over a long distance IP network (more than 3,000 km), in conjunction with the experimental verification of traffic control and scalable multicast technologies.

  20. High Resolution Cavity BPM for ILC Final Focal System (IP-BPM)

    CERN Document Server

    Nakamura, Tomoya; Inoue, Yoichi; Tauchi, Toshiaki; Urakawa, Junji; Sanuki, Tomoyuki; Komamiya, Sachio

    2007-01-01

    IP-BPM (Interaction Point Beam Position Monitor) is an ultra high resolution cavity BPM to be used at ATF2, a test facility for ILC final focus system. Control of beam position in 2 nm precision is required for ATF2. Beam tests at ATF extraction line proved a 8.7 nm position resolution.