WorldWideScience

Sample records for controle par courants

  1. Feedback control of current drive by using hybrid wave in tokamaks; Asservissement de la generation de courant par l`onde hybride dans un plasma de tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Wijnands, T.J. [Association Euratom-CEA, Centre d`Etudes Nucleaires de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee]|[CEA Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Direction des Sciences de la Matiere

    1997-03-01

    This work is focussed on an important and recent development in present day Controlled Nuclear Fusion Research and Tokamaks. The aim is to optimise the energy confinement for a certain magnetic configuration by adapting the radial distribution of the current. Of particular interest are feedback control scenarios with stationary modifications of the current profile using current, driven by Lower Hybrid waves. A new feedback control system has been developed for Tore Supra and has made a large number of new operation scenarios possible. In one of the experiments described here, there is no energy exchange between the poloidal field system and the plasma, the current is controlled by the power of the Lower Hybrid waves while the launched wave spectrum is used to optimise the current profile shape and the energy confinement. (author) 151 refs.

  2. Câbles electriques - Calcul du courant admissible - Partie 1: Equations de l'intensité du courant admissible (facteur de charge 100%) et calcul des pertes - Section 2: Facteurs de pertes par courants de Foucault dans les gaines dans le cas de deux circuits disposés en nappe

    CERN Document Server

    International Electrotechnical Commission. Geneva

    1993-01-01

    Câbles electriques - Calcul du courant admissible - Partie 1: Equations de l'intensité du courant admissible (facteur de charge 100%) et calcul des pertes - Section 2: Facteurs de pertes par courants de Foucault dans les gaines dans le cas de deux circuits disposés en nappe

  3. MODÉLISATION DES FLUX DE CHALEUR GÉNÉRÉS PAR FROTTEMENT GLISSANT DANS UN CONTACT CUIVRE-ACIER TRAVERSÉ PAR UN COURANT ÉLECTRIQUE

    Directory of Open Access Journals (Sweden)

    A BOUCHOUCHA

    2001-06-01

    Full Text Available Le problème de la conduction de la chaleur dans un contact électrique glissant cuivre–acier est étudié. Le couple fonctionne dans des conditions atmosphériques et est donc refroidi par convection naturelle à travers les faces latérales. En utilisant l'équation de la chaleur, un modèle de calcul de la température interfaciale a été élaboré. A l'aide de la méthode des volumes finis, les résultats de la température en fonction de la charge normale, la vitesse de glissement et le courant électrique sont donnés. Une comparaison avec la méthode d'Archard est faite. Les résultats montrent une bonne concordance. Une discussion globale du modèle élaboré et son application dans les contacts électriques glissants a été dégagée.

  4. Surface integral formulation of Maxwell's equations for simulation of non-destructive testing by eddy currents. Preliminary study on the implementation of the fast multipole method; Formulation integrale surfacique des equations de Maxwell pour la simulation de controles non destructifs par courant de Foucault. Etude preliminaire a la mise en oeuvre de la methode multipole rapide.

    Energy Technology Data Exchange (ETDEWEB)

    Lim, T.

    2011-04-28

    numeriquement un controle non destructif par courants de Foucault (CND-CF), la reponse du capteur peut etre modelisee via une approche semi-analytique par integrales de volume. Plus rapide que la methode des elements finis, cette approche est cependant limitee a l'etude de pieces planes ou cylindriques (sans prise en compte des effets de bords) du fait de la complexite de l'expression de la dyade de Green pour des configurations plus generales. Or, il existe une forte demande industrielle pour etendre les capacites de la modelisation CF a des configurations complexes (plaques deformees, bords de piece...). Nous avons donc ete amenes a formuler differemment le probleme electromagnetique, en nous fixant comme objectif de conserver une approche semi-analytique. La formulation integrale surfacique (SIE) permet d'exprimer le probleme volumique en un probleme de transmission equivalent a l'interface (2D) entre sous-domaines homogenes. Ce probleme est ramene a la resolution d'un systeme lineaire (par la methode des moments) dont le nombre d'inconnues est reduit du fait du caractere surfacique du maillage. Des lors, ce systeme peut etre resolu par un solveur direct pour de petites configurations. Cela nous a permis de traiter plusieurs seconds membres (ie. differentes positions de capteurs) pour une seule inversion de la matrice d'impedance. Les resultats numeriques obtenus au moyen de cette formulation concernent des plaques avec la prise en compte des effets de bords tels que l'arete et le coin. Ils sont en accord avec des resultats obtenus par la methode des elements finis. Pour des configurations de grandes tailles, nous avons mene une etude preliminaire a l'adaptation d'une methode d'acceleration du produit matrice-vecteur intervenant dans un solveur iteratif (methode multipole rapide, ou FMM) afin de definir les conditions dans lesquelles le calcul FMM fonctionne correctement (precision, convergence...) dans le contexte CND

  5. Resistivity measurements using a direct current induction method (1963); Mesure de resistivite par la methode d'induction en courant continu (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Delaplace, J; Hillairet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    toujours possible d'obtenir. Au contraire, la methode d'induction en courant continu que nous utilisons ne necessite aucun contact et s'applique tres bien aux echantillons de section importante. L'echantillon est place dans un champ magnetique uniforme; au moment ou l'on supprime le champ, des courants de Foucault, qui tendent a s'opposer a la disparition du champ, apparaissent dans l'echantillon. La loi de decroissance du flux magnetique dans l'echantillon permet de determiner la resistivite du materiau. Cette methode a ete appliquee a des echantillons de diametre compris entre 1 et 30 mm dans le cas de metaux bons conducteurs. Elle donne une valeur locale de la resistivite et permet d'en deceler toute variation le long d'un echantillon. Les mesures peuvent etre effectuees a toute temperature comprise entre quelques degres Kelvin et 500 deg. C. Nous avons utilise la methode d'induction pour suivre la purification du beryllium par fusion de zone: il est en effet possible d'evaluer la purete d'un materiau par des mesures de resistivite. Nous avons determine la valeur de la resistivite le long de chaque barreau de fusion de zone et localise ainsi la partie la plus pure. Des mesures a haute temperature ont ete faites sur le carbure d'uranium et sur des alliages fer-aluminium. Cette methode constitue un moyen d'investigation interessant de la resistivite des materiaux massifs. Sa precision et sa rapidite sont adaptees aussi bien aux etudes fondamentales qu'au controle de fabrication. (auteurs)

  6. Détermination en tridimensionnel des pertes par courant de Foucault dans la cuve d'un transformateur

    Science.gov (United States)

    Guérin, Christophe; Tanneau, Gérard; Meunier, Gérard; Sakellaris, Ioannis

    1993-03-01

    This paper deals with 3D electromagnetic modelling of a transformer so as to evaluate eddy current losses in the tank. In this purpose, several numerical methods have been used with two 3D softwares, FLUX3D (LEG) and TRIFOU (EDF). These methods use either nodal finite elements with the magnetic vector potential (FLUX3D), or the edge finite elements with the magnetic field as the state variable (TRIFOU). Classical volume elements and several special elements have been used : shell elements with the magnetic vector potential for the modelling of thin conducting regions, and surface elements for conducting regions with a small skin depth. The results given by these methods with several characteristics of the tank and magnetic core have been compared and their validity domain has been verified. The shell elements suit well when the skin depth is larger than the tank thickness, whereas in the opposite case, the surface elements for thin skin depth regions are well adapted. Nous présentons la modélisation tridimensionnelle d'un transformateur pour la détermination des pertes par courants de Foucault dans sa cuve. Pour cela, plusieurs méthodes numériques ont été utilisées à l'aide de deux codes de calcul tridimensionnels : FLUX3D (LEG) et TRIFOU (EDF). Ces méthodes utilisent soit les éléments finis nodaux avec le potentiel vecteur magnétique (FLUX3D), soit les éléments finis d'arête avec le champ magnétique comme variable d'état (TRIFOU). Outre l'utilisation des éléments volumiques, nous avons employé des éléments surfaciques de type coque en potentiel vecteur magnétique pour la modélisation de regions conductrices minces, ainsi que des éléments surfaciques pour les régions conductrices présentant une faible épaisseur de peau. Les résultats obtenus avec ces méthodes pour différentes caractéristiques du matériau de la cuve et du circuit magnétique ont permis de vérifier leur domaine de validité. Les éléments de type coque conviennent

  7. Some Possibilities of the Eddy-Current Method for Multi-Parameter Testing of Structural Components; Quelques Possibilites Offertes par la Methode des Courants de Foucault pour le Controle de Nombreux Parametres des Elements de Construction; Nekotorye vozmozhnosti metoda vikhrevykh tokov dlya mnogoparametrovogo kontrolya ehlementov konstruktsij; Algunas Posibilidades que Brinda el Metodo de las Corrientes de Foucault para Controlar Numerosos Parametros de los Elementos de Construccion

    Energy Technology Data Exchange (ETDEWEB)

    Vjahorev, V. G.; Gerasimov, V. G.; Deniskin, V. P.; Trahtenberg, L. I.; Shkarlet, Ju. M. [Gosudarstvennyj Komitet po Ispol' zovaniju Atomnoj Jenergii SSSR, Moskva, SSSR (Russian Federation)

    1965-09-15

    The paper discusses the pattern of occurrence of problems of non-destructive multiparameter testing in nuclear technology and the advisability of approaching these problems by the eddy-current method. The application of electric models is justified for solving testing problems using a long follow-through coil. Design formulae are given and the principles of designing applied eddy-current probes are explained. An arrangement for testing tube-wall thickness is described: in this apparatus the effect of movement of the tube under testing on the measurement results is eliminated with the aid of a servo-system controlled by a signal depending on the probe voltage phase. The paper describes how a self-oscillating circuit containing a test-coil is used as the probe of an apparatus for testing tubes. On the basis of calculated and experimental data various possibilities are indicated for the construction of single-frequency applied eddy-current testing probes for simultaneous measurement of more than two parameters. (author) [French] Les auteurs montrent que les problemes du controle non-destructif de plusieurs parametres en technologie nucleaire surgissent selon certaines lois et que la methode des courants de Foucault convient particulierement a la solution de plusieurs d'entre eux. Ils justifient l'utilisation de modeles electriques pour la solution des problemes de controle au moyen d'une longue bobine creuse. Us donnent des formules et exposent une methode pour le calcul de detecteurs a courants de Foucault. Us decrivent le schema d'un dispositif permettant de verifier l'epaisseur des parois de tubes, dans lequel le deplacement du tube a controler n'exerce aucune influence sur les resultats des mesures grace a l'emploi d'un moniteur actionne par un signal qui depend de la phase de tension du detecteur. Comme detecteur, on a employe un dispositif destine au controle des tubes d'un autogenerateur, apres avoir inclus dans son circuit une bobine d'essai. En partant des

  8. Contrôle non destructif par courants de Foucault : expérience et modélisation pour la conception et l'optimisation de capteurs

    Science.gov (United States)

    Bonnin, O.; Cahouet, J.; Giordano, P.

    1993-03-01

    more accurate comparison, for example on the crack depth, is difficult because of the uncertainty on the physical properties of the materials. Dans le cadre d'un projet industiel de conception et d'optimisation de capteurs pour la recherche de fissures par courants de Foucault sur les plate-formes de forage, on présente les études menées pour la modélisation du système. La simulation des phénomènes implique à priori une modélisation tridimensionnelle, certes précise, mais difficile et coûteuse. On cherche à en limiter le coût en combinant une modélisation bidimensionnelle en l'absence de défaut, et une modélisation tridimensionnelle locale en présence d'une fissure. Après avoir présenté le projet et l'étude expérimentale qui en découle, on décrit les techniques de modélisation qui ont été employées.

  9. Current algebra; Algebre des courants

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The first three chapters of these lecture notes are devoted to generalities concerning current algebra. The weak currents are defined, and their main properties given (V-A hypothesis, conserved vector current, selection rules, partially conserved axial current,...). The SU (3) x SU (3) algebra of Gell-Mann is introduced, and the general properties of the non-leptonic weak Hamiltonian are discussed. Chapters 4 to 9 are devoted to some important applications of the algebra. First one proves the Adler- Weisberger formula, in two different ways, by either the infinite momentum frame, or the near-by singularities method. In the others chapters, the latter method is the only one used. The following topics are successively dealt with: semi leptonic decays of K mesons and hyperons, Kroll- Ruderman theorem, non leptonic decays of K mesons and hyperons ( {delta}I = 1/2 rule), low energy theorems concerning processes with emission (or absorption) of a pion or a photon, super-convergence sum rules, and finally, neutrino reactions. (author) [French] La premiere partie de ce cours (trois premiers chapitres), traite des generalites concernant l'algebre de courants. Apres une definition rapide des courants faibles et un rappel de leurs proprietes (hypothese V-A, conservation du courant vecteur, regles de selection, courant axial partiellement conserve,...), l'on introduit l'algebre de Gell-Mann SU (3) x SU (3), et discute les proprietes generales de l'Hamiltonien faible non leptonique. Les chapitres IV a IX sont consacres a des applications importantes de l'algebre des courants. En premier lieu l'on demontre la formule de Adler et Weisberger, par deux methodes differentes, celle dite du repere de moment infini et celle des singularites proches. Cette derniere est seule utilisee dans la suite. Puis, l'on traite successivement les problemes suivants: desintegrations semi-leptoniques des mesons K et des hyperons, theoreme de Kroll-Ruderman, desintegrations non leptoniques des mesons

  10. Livingston-Courant magnetic lens and their use in focussing a beam supplied by a Van der Graaff; Lentilles magnetiques Courant-Livingston et leur utilisation a la focalisation du faisceau donne par un Van de Graaff

    Energy Technology Data Exchange (ETDEWEB)

    Gendreau, G.

    1953-11-15

    This technical note presents the general calculation of focal distances of a system made of two crossed thick lens. It outlines that these lens can be considered as thin lens in their operation domain (focal distance comprised between an element length and the infinite), and then elaborated formula for all optical elements. These formula are then applied to lens built for the Van der Graaff. The actual length of a lens is then given with respect to its theoretical length. Obtained numerical values lead to the determination of magnetic and mechanical characteristics of a lens [French] Le calcul general des distances focales d'un systeme de deux lentilles epaisses croisees est explicite. Dans leur domaine d'utilisation (distances focales comprises entre l'infini et la longueur d'un element) on peut les considerer comme minces, tous les elements optiques sont alors formules. L'application de ces formules aux lentilles construites pour le Van de Graaff se traduit par les tableaux I et II. On donne la longueur reelle d'une lentille en fonction de sa longueur theorique. Les valeurs numeriques trouvees conduisent a la determination des caracteristiques magnetiques et mecaniques d'une lentille. (auteur)

  11. Limiteurs de courant supraconducteurs

    OpenAIRE

    Verhaege , T.; Bekhaled , M.; Laumond , Y.; Pham , V.; Thomas , P.; Thérond , P.

    1994-01-01

    L'électrotechnique industrielle à 50-60 Hz représente pour les supraconducteurs un marché potentiel considérable. Parmi les applications envisageables, la limitation des courants de défaut sera probablement la première à trouver un essor industriel. Les propriétés mises en jeu sont tout à fait spécifiques des supraconducteurs, à savoir le grand contraste existant entre un état passant à haute densité de courant, et un état bloquant à haute résistivité, obtenu dès que le courant dépasse un seu...

  12. Sélection et utilisation de l'habitat par les jeunes stades de poissons d'eau courante : le modèle Ombre commun (Thymallus thymallus, L.

    Directory of Open Access Journals (Sweden)

    SEMPESKI P.

    1995-04-01

    Full Text Available L'Ombre commun a servi de modèle biologique dans le cadre de l'étude de la dynamique des changements d'habitats caractérisant les jeunes stades de poissons d'eau courante. Des campagnes d'observations directes, depuis la berge ou en plongée, de jour comme de nuit, associées à des descriptions de l'habitat physique et des prélèvements de poissons et de faune invertébrée benthique et dérivante, ont permis une analyse fine de la sélection et de l'utilisation de l'habitat par les jeunes stades d'ombre et de leur évolution à différentes échelles spatio-temporelles. Différents groupes fonctionnels ont pu être distingués parmi les stades larvaires et juvéniles, en fonction des microhabitats sélectionnés de jour (alimentation et de nuit (repos, et des différentes stratégies de sélection des proies.

  13. Limiteurs de courant supraconducteurs

    Science.gov (United States)

    Verhaege, T.; Bekhaled, M.; Laumond, Y.; Pham, V. D.; Thomas, P.; Thérond, P. G.

    1994-04-01

    50-60 Hz electrical engineering represents a considerable potential market for superconductors. Fault current limitation will probably be the first among the possible applications, to find an industrial opening. Exploited features are very specific of the superconductors, namely the large contrast existing between an on-state with high current density and an off-state with high electrical resistivity, obtained as soon as the current reaches a specified level. It thus becomes possible to warrant the grid from any current excursion over a specified value, with considerable impact on the protection and dimensions of conductors and devices, and increased possibilities of interconnexion. The current limiter technology is rather complex ; different structures have been proposed and tested ; they are resistive or inductive, based on low-T_c or high-T_c superconductors. The most advanced candidate to date is a resistive structure, using conductors made of ultra-fine niobium-titanium filaments in a coppemickel matrix, whose essential features are described hereunder. L'électrotechnique industrielle à 50-60 Hz représente pour les supraconducteurs un marché potentiel considérable. Parmi les applications envisageables, la limitation des courants de défaut sera probablement la première à trouver un essor industriel. Les propriétés mises en jeu sont tout à fait spécifiques des supraconducteurs, à savoir le grand contraste existant entre un état passant à haute densité de courant, et un état bloquant à haute résistivité, obtenu dès que le courant dépasse un seuil donné. Il est ainsi possible de garantir le réseau contre toute excursion du courant au-delà d'une valeur spécifiée, avec un impact important sur sa protection, son dimensionnement, son degré d'interconnexion. La technologie du limiteur de courant est assez complexe ; diverses structures ont été proposées et testées, résistives ou inductives, à base de supraconducteurs BTc ou HTc. Le

  14. Power frequency electric and magnetic fields: Questions and answers; Champs electriques et magnetiques produits par le courant industriel: Questions et reponses

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-10-01

    Power frequency fields are electric and magnetic fields produced by electric power. The first evidence to show that power frequency fields may have an effect on human health was noted in 1972 when it was reported that workers in high voltage switchyards suffered from a number of ailments. Fundamentals of electric and magnetic fields, and methods of their measurement, are explained. Some sources of power frequency fields are reviewed, and measured occupational exposures to these fields by electric utility workers are listed. Possible biological and health effects from power frequency fields are summarized from epidemiological, whole-animal, cellular, and observational studies reported in the literature. These include increased risk of cancer, decrease in melatonin, reproductive and developmental abnormalities, decreased heart rates, changes in calcium flow across cell membranes, and changes in neurotransmitters and corticosterone. Exposure standards for power frequency fields are given and methods for controlling exposure to those fields are noted. 53 refs., 1 fig., 2 tabs.

  15. Déshumidification de l'air d'une serre par contact direct à courants croisés avec une solution hygroscopique organique

    Science.gov (United States)

    Chraibi, A.; Jaffrin, A.; Makhlouf, S.; Bentounes, N.

    1995-07-01

    Greenhouse air can be dehumidified by direct contact with a desicant fluid on a trickle exchanger. The water vapour extraction rate depends on the hygroscopicity of the fluid and on the exchanger efficiency. An organic fluid, the triethylene glycol (TEG) at 90% concentration, has been tested. Cross corrugated cellulosic pads, of the type used in cooling, irrigated with TEG, were placed in a wind channel to dehumidify air at various speeds and temperatures. A semi-analytical model, based on energy and mass conservation, correctly reproduces the water vapor extraction rate and the enthalpy change of both fluids. It is shown that TEG trickling through a ventilated pad of 1 m^2 area and 0.1 m thickness can be used to extract 3 to 5 kg of water vapor per hour in greenhouse climate control applications. Several pads arranged in series can be used to decrease more efficiently the absolute humidity of the air, for other applications like food drying or industrial compressed air. Une technique de déshumidification de l'air des serres consiste à le soumettre au contact d'une solution hygroscopique au sein d'un échangeur ruisselant. Le taux d'extraction de vapeur d'eau dépend à la fois du pouvoir hygroscopique de la solution et de l'efficacité de l'échangeur. Une solution hygroscopique organique, le triéthylène glycol à 90% de concentration, a été expérimentée. Un échangeur ruisselant constitué de parois de cellulose ondulées à corrugations croisées, du type “cooling pad” pour serres agricoles, a été testé pour déshumidifier de l'air dans une soufflerie expérimentale. Un modèle semi-analytique, basé sur les équations de conservation de l'énergie et de masse, permet de rendre compte des échanges et de déduire les paramètres de sortie des deux fluides en contact, à partir des caractéristiques d'entrée. Cette étude permet de chiffrer à environ 3 à 5kg/h la capacité de déshumidification d'un panneau d'un mètre carré et de 10cm d

  16. Separation of calcium isotopes by counter-current electromigration in molten salts (1962); Separation des isotopes du calcium par electro-migration a contre-courant en sels fondus (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Menes, F; Dirian, G; Roth, E [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    The method of counter-current electromigration in molten salts has been applied to calcium bromide with an alkali metal bromide added to the cathode compartment. Enrichments on calcium-46 greater than a factor of two were obtained at the anode. The mass effect was found to be about 0.06. An estimation of the cost of energy for a process based on this method has been made. (authors) [French] La methode d'electro-migration a contre-courant en sels fondus a ete appliquee au bromure de calcium additionne dans le compartiment cathodique d'un bromure alcalin. On a pu ainsi obtenir avec surete des enrichissements anodiques superieurs a 2 sur l'isotope 46, determiner l'effet de masse (environ 0,06) et faire une estimation sommaire du cout energetique d'un procede base sur cette methode. (auteurs)

  17. PARs for combustible gas control in advanced light water reactors

    International Nuclear Information System (INIS)

    Hosler, J.; Sliter, G.

    1997-01-01

    This paper discusses the progress being made in the United States to introduce passive autocatalytic recombiner (PAR) technology as a cost-effective alternative to electric recombiners for controlling combustible gas produced in postulated accidents in both future Advanced Light Water Reactors (ALWRs) and certain U. S. operating nuclear plants. PARs catalytically recombine hydrogen and oxygen, gradually producing heat and water vapor. They have no moving parts and are self-starting and self-feeding, even under relatively cold and wet containment conditions. Buoyancy of the hot gases they create sets up natural convective flow that promotes mixing of combustible gases in a containment. In a non-inerted ALWR containment, two approaches each employing a combination of PARs and igniters are being considered to control hydrogen in design basis and severe accidents. In pre-inerted ALWRs, PARs alone control radiolytic oxygen produced in either accident type. The paper also discusses regulatory feedback regarding these combustible gas control approaches and describes a test program being conducted by the Electric Power Research Institute (EPRI) and Electricite de France (EdF) to supplement the existing PAR test database with performance data under conditions of interest to U.S. plants. Preliminary findings from the EPRI/EdF PAR model test program are included. Successful completion of this test program and confirmatory tests being sponsored by the U. S. NRC are expected to pave the way for use of PARs in ALWRs and operating plants. (author)

  18. Courant algebroid connections and string effective actions

    OpenAIRE

    Jurčo, B.

    2017-01-01

    Courant algebroids are a natural generalization of quadratic Lie algebras, appearing in various contexts in mathematical physics. A connection on a Courant algebroid gives an analogue of a covariant derivative compatible with a given fiber-wise metric. Imposing further conditions resembling standard Levi-Civita connections, one obtains a class of connections whose curvature tensor in certain cases gives a new geometrical description of equations of motion of low energy effective action of str...

  19. Les supraconducteurs en courant alternatif

    Science.gov (United States)

    Lacaze, A.; Laumond, Y.

    1991-02-01

    Since 1983, when the very first AC wire became available, the comprehension of electromagnetic phenomenas ruling over stability and losses of multifilamentary superconductors in AC use, has much improved. Improvements of manufacturing process has opened up the possibility of industrial scale manufacturing of up to one million, 140 nm in diameter, filaments. The AC loss performances and stability remains at the best level up to date. Les premiers brins supraconducteurs utilisables en courants alternatifs sont apparus en 1983. Depuis, des progrès importants ont été réalisés sur le plan de la compréhension des phénomènes électromagnétiques commandant les pertes et la stabilité dans des brins multifilamentaires à filaments ultrafins. L'amélioration des performances et des procédés de fabrication nous permet aujourd'hui de présenter des brins, fabriqués à l'échelle industrielle, comprenant jusqu'à près d'un million de filaments de 140 nm de diamètre, avec des niveaux de pertes et de stabilité inégalés à ce jour.

  20. Eddy current probe development based on a magnetic sensor array; Developpement d'un imageur magnetique pour le controle non destructif par courants de Foucault

    Energy Technology Data Exchange (ETDEWEB)

    Vacher, F

    2007-06-15

    This research deals with in the study of the use of innovating magnetic sensors in eddy current non destructive inspection. The author reports an analysis survey of magnetic sensor performances. This survey enables the selection of magnetic sensor technologies used in non destructive inspection. He presents the state-of-the-art of eddy current probes exploiting the qualities of innovating magnetic sensors, and describes the methods enabling the use of these magnetic sensors in non destructive testing. Two main applications of innovating magnetic sensors are identified: the detection of very small defects by means of magneto-resistive sensors, and the detection of deep defects by means of giant magneto-impedances. Based on the use of modelling, optimization, signal processing tools, probes are manufactured for these both applications.

  1. Monitoring of the current profile by using cyclotronic electron waves in tokamaks; Controle du profil de courant par ondes cyclotroniques electroniques dans les tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Dumont, R

    2001-08-01

    The subject of this thesis is the study of the cyclotronic electron wave as a monitoring tool of the current profile. The first chapter is dedicated to basic notions concerning tokamak plasmas and current generation. The second chapter is centered on the use of fast electrons to generate current and on its modelling. The propagation and absorption of the cyclotronic electron wave require a specific polarization state whose characteristics must be carefully chosen according to some parameters of the discharge, the chapter 3 deals with this topic. The absorption of a wave in a plasma depends greatly on the velocity distribution of the particles that make up the plasma and this distribution is constantly modified by the energy of the wave, so this phenomenon is non-linear and its physical description is difficult. In a case of a fusion plasma, a sophisticated approximation called quasi-linear theory can be applied with some restrictions that are presented in chapter 4. Chapters 5 and 6 are dedicated to kinetics scenarios involving the low hybrid wave and the cyclotronic electron wave inside the plasma. Some experiments dedicated to the study of the cyclotronic electron wave have been performed in Tore-supra (France) and FTU (Italy) tokamaks, they are presented in the last chapter. (A.C.)

  2. Prise en compte des ``courants de London'' dans la modélisation des supraconducteurs

    Science.gov (United States)

    Bossavit, Alain

    1997-10-01

    A model is given, in variational form, in which volumic “Bean currents”, ruled by Bean's law, and surface “London currents” coexist. This macroscopic model generalizes Bean's one, by appending to the critical density j_c a second parameter, with the dimension of a length, similar to London's depth λ. The one-dimensional version of the model is investigated, in order to link this parameter with the standard observable H-M characteristics On propose un modèle, sous forme variationnelle, associant des “courants de Bean” volumiques, décrits par la loi de Bean, et des “courants de London”, surfaciques. Ce modèle macroscopique généralise celui de Bean, caractérisé par le courant critique j_c, et fait intervenir un second paramètre, homogène à une longueur, analogue au λ de London. La version unidimensionnelle du modèle est étudiée en détail de manière à relier ce paramètre à l'observation des caractéristiques H-M usuelles.

  3. Superconducting current generators; Generateurs supraconducteurs de courant

    Energy Technology Data Exchange (ETDEWEB)

    Genevey, P [Commissariat a l' Energie Atomique, Limeil-Brevannes (France). Centre d' Etudes

    1970-07-01

    After a brief summary of the principle of energy storage and liberation with superconducting coils,two current generators are described that create currents in the range 600 to 1400 A, used for two storage experiments of 25 kJ and 50 kJ respectively. The two current generators are: a) a flux pump and b) a superconducting transformer. Both could be developed into more powerful units. The study shows the advantage of the transformer over the flux pump in order to create large currents. The efficiencies of the two generators are 95 per cent and 40 to 60 per cent respectively. (author) [French] Apres un rappel succinct du principe de stockage d'energie dans un solenoide supraconducteur et de sa liberation, nous decrivons deux generateurs de courant qui nous ont permis d'obtenir les courants necessaires (600 a 1400 A) aux experiences de stockage d'energie envisagees (27 kJ et 50 kJ): 1) - une pompe a flux, 2) - un transformateur supraconducteur. Ces generateurs sont extrapolables. Cette etude montre que si nous voulons creer un courant intense, le transformateur grace a son rendement eleve (> 95 pour cent) est preferable actuellement aux pompes a flux dont le rendement est de 40 a 60 pour cent. (auteur)

  4. High-dilution on-stream isotopic tracer techniques; Emploi d'indicateurs radioactifs tres dilues pour le controle les courants; Metody primeneniya sil'no razbavlennykh v potokakh izotopnykh indikatorov; Empleo de indicadores radiactivos muy diluidos en el control de corrientes

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, W H; Findeis, A F; Vestal, M [William H . Johnston Laboratories, Inc., Baltimore, MD (United States)

    1962-01-15

    temps desire pour la mesure de l'echantillon et du rayonnement ambiant, la vitesse du courant et le radioelement utilise comme tracteur. Ils donnent une representation graphique de ces equations qui permet de determiner rapidement la concentration a adopter pour telle ou telle application. Le memoire analyse le programme d'echantillonnage pour l'emploi a grande echelle d'indicateurs injectes de facon continue ou par intermittence. Dans ce dernier cas, on etudie le melange longitudinal en appliquant les coefficients de diffusion par turbulence. En estimant certains parametres, on obtient les limites longitudinales de detection des traceurs et le temps d'arrivee en fonction de la distance entre le point d'injection et l'endroit ou se fait l'echantillonnage. Pour le controle au moyen d'emetteurs beta tres dilues, les detecteurs utilises sont de grands compteurs avec tube a gaz pour faibles intensites, des compteurs a feuilles et a flux continu et des scintillateurs en plastique. Les auteurs donnent des renseignements sur nouveaux compteurs a anticoincidence et soulignent les avantages de la protection au moyen d'elements a. faible nombre atomique. Le memoire rend compte des progres recents dans le domaine des circuits electroniques stables a transistors pour le comptage de faibles intensites et decrit un nouvel amplificateur et un nouveau circuit additionneur a diode . Il donne aussi des exemples de plusieurs applications nouvelles des indicateurs tres dilues pour l'identification des sources de pollution dans les fleuves et les cours d'eau. (author) [Spanish] Los autores estudian las aplicaciones en gran escala de trazadores en las que se procede a la marcacion isotopica de uno de los componentes de una corriente o fluido en movimiento, sin separarlo despues de la corriente principal. Los autores obtienen ecuaciones que permiten establecer relaciones entre las concentraciones a que se ha de utilizar el trazador, la actividad de fondo de los instrumentos, la

  5. Fast measure proceeding of weak currents; Un procede de mesure rapide des courants faibles

    Energy Technology Data Exchange (ETDEWEB)

    Taieb, J [Commissariat a l' Energie Atomique, Siege (France). Centre d' Etudes Nucleaires

    1953-07-01

    The process of fast measure of the weak currents that we are going to describe briefly apply worthy of the provided currents by the sources to elevated value internal resistance, as it is the case for the ionization chamber, the photocells, mass spectroscopic tubes. The problem to measure weak currents is essentially a problem of amplifier and of input circuit. We intended to achieve a whole amplifier and input circuit with advanced performances, meaning that for a measured celerity we wanted to have an signal/noise ratio the most important as in the classic systems and for a same report signal/noise a more quickly done measure. (M.B.) [French] Le procede de mesure rapide des courants faibles que nous allons brievement decrire s'applique a la mesure des courants fournis par les sources a resistance interne de valeur elevee, comme c'est le cas pour les chambres d'ionisation, les photocellules, les tubes de spectrographe de masse. Le probleme de mesure de courants faibles est essentiellement un probleme d'amplificateur et de circuit d'entree. Nous nous sommes proposes de realiser un ensemble amplificateur et circuit d'entree a performances poussees, c'est a dire que pour une meme rapidite de mesure nous desirions avoir un rapport signal/bruit plus important que dans les systemes classiques et pour un meme rapport signal/bruit une mesure effectuee plus rapidement. (M.B.)

  6. Turbulent Heating of Plasma by a Direct-Current Discharge; Chauffage Turbulent du Plasma par le Courant d'une Decharge Directe; ТУРБУЛЕНТНЫЙ НАГРЕВ ПЛАЗМЫ ТОКОМ ПРЯМОГО РАЗРЯДА; Calentamiento Turbulento del Plasma por una Corriente de Descarga Directa

    Energy Technology Data Exchange (ETDEWEB)

    Babykin, M. V.; Gavrin, P. P.; Zavojskij, E. K.; Rudakov, L. I.; Skorjupin, V. A. [Institut Atomnoj Ehnergii Im. I.V. Kurchatova, Moskva, SSSR (Russian Federation)

    1966-04-15

    , accordingly, persists even after transition to the oscillatory regime. The plasma temperature, determined from the hardness of the X-ray bremsstrahlung, was 5 to 10 keV. The density was determined by a microwave interferometer. The plasma pressure, estimated from the diamagnetic effect was Tilde-Operator 10{sup 17} eV cm{sup -3}. For n Greater-Than-Or-Equivalent-To 2 x 10{sup 13} cm{sup -3} this gives a temperature of Tilde-Operator 5 keV, which agrees with other measurements. At a density of the heated plasma of less than 10{sup 13} cm{sup -3} it is compressed adiabatically, remaining stable. The electron temperature after compression attains 200 keV. When the initial plasma density is increased its temperature after heating is lower and no compression occurs. A signal with frequency 3 x 10{sup 8} c/s was passed through the plasma during the instability of the current. In a strongly turbulent plasma the thickness of the skin layer considerably exceeds c/{omega}{rho} and an interpretation of this phenomenon is put forward. The mechanism of plasma heating when there is a current instability is discussed. A detailed theory is put forward in a separate paper. (author) [French] Les auteurs exposent les resultats qu'ils ont obtenus en procedant a des experiences sur le chauffage turbulent du plasma par le courant d'une decharge directe dans une machine a miroirs magnetiques. Ils ont egalement etudie la compression adiabatique du plasma chauffe et certaines proprietes du plasma turbulent. Le champ magnetique a ete porte a 9 kOe en 1,75 ms. En presence de champs de 0,5 a 9 kOe, on a rempli la machine de plasma de deuterium, dont la densite etait de 10{sup 12} a 10{sup 1}'3 cm{sup -3}, en utilisant des canons a titane. Simultanement, on a intercale entre les electrodes terminales une cavite a decharge directe, ayant une tension maximum de 10 a 30 kV et representant, selon les experiences, 0,2, 0,8 et 2,65 {mu}F. La decharge commencait au moment meme ou les jets de plasma se

  7. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P.

    2012-01-01

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  8. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G; Lewis, Mark; Juette, Arne; Cahir, John G; Toms, Andoni P [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  9. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  10. Identification and real time control of current profile in Tore-supra: algorithms and simulation; Identification et controle en temps reel du profil de courant dans Tore Supra: algorithmes et simulations

    Energy Technology Data Exchange (ETDEWEB)

    Houy, P

    1999-10-15

    The aim of this work is to propose a real-time control of the current profile in order to achieve reproducible operating modes with improved energetic confinement in tokamaks. The determination of the profile is based on measurements given by interferometry and polarimetry diagnostics. Different ways to evaluate and improve the accuracy of these measurements are exposed. The position and the shape of a plasma are controlled by the poloidal system that forces them to cope with standard values. Gas or neutral ions or ice pellet or extra power injection are technical means used to control other plasma parameters. These controls are performed by servo-controlled loops. The poloidal system of Tore-supra is presented. The main obstacle to a reliable determination of the current profile is the fact that slightly different Faraday angles lead to very different profiles. The direct identification method that is exposed in this work, gives the profile that minimizes the square of the margin between measured and computed values. The different algorithms proposed to control current profiles on Tore-supra have been validated by using a plasma simulation. The code Cronos that solves the resistive diffusion equation of current has been used. (A.C.)

  11. Etude de la performance des radars hautes-frequences CODAR et WERA pour la mesure des courants marins en presence partielle de glace de mer

    Science.gov (United States)

    Kamli, Emna

    Les radars hautes-frequences (RHF) mesurent les courants marins de surface avec une portee pouvant atteindre 200 kilometres et une resolution de l'ordre du kilometre. Cette etude a pour but de caracteriser la performance des RHF, en terme de couverture spatiale, pour la mesure des courants de surface en presence partielle de glace de mer. Pour ce faire, les mesures des courants de deux radars de type CODAR sur la rive sud de l'estuaire maritime du Saint-Laurent, et d'un radar de type WERA sur la rive nord, prises pendant l'hiver 2013, ont ete utilisees. Dans un premier temps, l'aire moyenne journaliere de la zone ou les courants sont mesures par chaque radar a ete comparee a l'energie des vagues de Bragg calculee a partir des donnees brutes d'acceleration fournies par une bouee mouillee dans la zone couverte par les radars. La couverture des CODARs est dependante de la densite d'energie de Bragg, alors que la couverture du WERA y est pratiquement insensible. Un modele de fetch appele GENER a ete force par la vitesse du vent predite par le modele GEM d'Environnement Canada pour estimer la hauteur significative ainsi que la periode modale des vagues. A partir de ces parametres, la densite d'energie des vagues de Bragg a ete evaluee pendant l'hiver a l'aide du spectre theorique de Bretschneider. Ces resultats permettent d'etablir la couverture normale de chaque radar en absence de glace de mer. La concentration de glace de mer, predite par le systeme canadien operationnel de prevision glace-ocean, a ete moyennee sur les differents fetchs du vent selon la direction moyenne journaliere des vagues predites par GENER. Dans un deuxieme temps, la relation entre le ratio des couvertures journalieres obtenues pendant l'hiver 2013 et des couvertures normales de chaque radar d'une part, et la concentration moyenne journaliere de glace de mer d'autre part, a ete etablie. Le ratio des couvertures decroit avec l'augmentation de la concentration de glace de mer pour les deux types

  12. Development of a 3-D model for eddy current testing: application for fastened structures in aeronautics; Developpement d'un modele pour le controle non destructif par courants de Foucault de structures rivetees en aeronautique

    Energy Technology Data Exchange (ETDEWEB)

    Paillard, S

    2007-12-15

    One of the Eddy Current Testing issues in aeronautics is the inspection of fastened structures to detect flaws nearby rivets which can grow because of mechanical stress. EADS and the CEA LIST have started a collaborative work with the support of the Ile-de-France Region to develop a simulation tool of EC fastened structures testing, integrated to the CIVA platform, aimed at conceiving testing methods, optimizing and qualifying it. The volume integral method using the Green dyadics formalism has been chosen in order to get a fast resolution of Maxwell equations. A first milestone was to build a simulation model of multilayer structures testing, thanks to the use of the multilayer Green dyads. Because of the rivet volume, 60 times bigger than the one of a typical flaw, a large number of discretization cells are needed. Therefore an iterative method has been developed in order to numerically solve large calculation zones. Finally, the flaw response simulation mostly has to cope with a scale issue between the size of the rivet and the one of the flaw, the latter being much smaller in a direction than the former. The whole model has been experimentally validated and compared to other simulation models at the important development steps: multilayer configuration, iteration resolution, and flaw signature. (author)

  13. Development and validation of a simulation tool dedicated to eddy current non destructive testing of tubes; Developpement d'un modele electromagnetique 3D pour la simulation du controle par Courants de Foucault de tubes en fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Reboud, Ch

    2006-09-15

    Eddy current testing (ECT) technique is widely used in industrial fields such as iron and steel industry. Dedicated simulation tools provide a great assistance for the optimisation of ECT processes. CEA and the Vallourec Research Center have collaborated in order to develop a simulation tool of ECT of tubes. The volume integral method has been chosen for the resolution of Maxwell equations in a stratified medium, in order to get accurate results with a computation time short enough to carry out optimisation or inversion procedures. A fast model has been developed for the simulation of ECT of non magnetic tubes using specific external probes. New flaw geometries have been modelled: holes and notches with flat bottom. Validations of the developments, which have been integrated to the CIVA platform, have been carried out using experimental data recorded in laboratory conditions and in. industrial conditions, successively. The integral equations derived are solved using the Galerkin variant of the method of moments with pulse functions as projection functions. In order to overcome some memory limitations, other projection functions have been considered. A new discretization scheme based on non-uniform B-Splines of degree 1 or 2 has been implemented, which constitutes an original contribution to the existing literature. The decrease of the mesh size needed to get a given accuracy on the result may lead to the simulation of more complex ECT configurations. (author)

  14. Controlling absence seizures by deep brain stimulus applied on substantia nigra pars reticulata and cortex

    International Nuclear Information System (INIS)

    Hu, Bing; Wang, Qingyun

    2015-01-01

    Epilepsy is a typical neural disease in nervous system, and the control of seizures is very important for treating the epilepsy. It is well known that the drug treatment is the main strategy for controlling the epilepsy. However, there are about 10–15 percent of patients, whose seizures cannot be effectively controlled by means of the drug. Alternatively, the deep brain stimulus (DBS) technology is a feasible method to control the serious seizures. However, theoretical explorations of DBS are still absent, and need to be further made. Presently, we will explore to control the absence seizures by introducing the DBS to a basal ganglia thalamocortical network model. In particular, we apply DBS onto substantia nigra pars reticulata (SNr) and the cortex to explore its effects on controlling absence seizures, respectively. We can find that the absence seizure can be well controlled within suitable parameter ranges by tuning the period and duration of current stimulation as DBS is implemented in the SNr. And also, as the DBS is applied onto the cortex, it is shown that for the ranges of present parameters, only adjusting the duration of current stimulation is an effective control method for the absence seizures. The obtained results can have better understanding for the mechanism of DBS in the medical treatment.

  15. Optimum input leads for cryogenic apparatus; Optimisation des descentes de courant dans des enceintes cryogeniques

    Energy Technology Data Exchange (ETDEWEB)

    Der Nigohossian, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-02-15

    The electrical leads used to introduce a current into a cryostat cause a heat influx due to thermal conduction and to Joule heating. It is very important to be able to minimize this flux. Theoretical calculation of optimized leads takes into account the varying heat and electrical conductivities of the leads as well as the heat exchange coefficient with the effluent gas. Practical results have been summarized in different tables which permit for a specific material i.e. copper, aluminium, brass, stainless steel with the intensity and end temperatures being known (i.e. 4,2 or 18,5 deg. K at the cold end; 77,295 or 320 deg. K at the warm end) to deduce the minimum heat flow and the length-cross section ratio of the optimized leads. A general method is indicated, which would allow to solve the same problem for other materials. (author) [French] Les conducteurs electriques assurant la liaison d'appareillages situes dans des cryostats apportent tant par effet Joule que par conductibilite thermique une certaine quantite de chaleur qu'il est tres important de pouvoir minimiser. L'etude theorique de l'optimisation des descentes de courant tient compte des variations des conductibilites thermique et electrique ainsi que de l'influence des echanges avec le gaz. Pratiquement les resultats ont ete resumes dans differents tableaux ce qui permet, pour un materiau donne tel que cuivre, aluminium, laiton, acier inoxydable, connaissant l'intensite et les temperatures d'extremites 4,2 et 18,5 deg. K d'une part, et 77,295 et 330 deg. K d'autre part, de deduire la consommation minimale et le rapport longueur-section d'un conducteur optimise. Une methode generale est indiquee, qui permet de resoudre le probleme pour d'autres materiaux. (auteur)

  16. Tailless and Atrophin control Drosophila aggression by regulating neuropeptide signalling in the pars intercerebralis

    Science.gov (United States)

    Davis, Shaun M.; Thomas, Amanda L.; Nomie, Krystle J.; Huang, Longwen; Dierick, Herman A.

    2014-02-01

    Aggressive behaviour is widespread throughout the animal kingdom. However, its mechanisms are poorly understood, and the degree of molecular conservation between distantly related species is unknown. Here we show that knockdown of tailless (tll) increases aggression in Drosophila, similar to the effect of its mouse orthologue Nr2e1. Tll localizes to the adult pars intercerebralis (PI), which shows similarity to the mammalian hypothalamus. Knockdown of tll in the PI is sufficient to increase aggression and is rescued by co-expressing human NR2E1. Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both proteins physically interact in the PI. tll knockdown-induced aggression is fully suppressed by blocking neuropeptide processing or release from the PI. In addition, genetically activating PI neurons increases aggression, mimicking the aggression-inducing effect of hypothalamic stimulation. Together, our results suggest that a transcriptional control module regulates neuropeptide signalling from the neurosecretory cells of the brain to control aggressive behaviour.

  17. uPAR-controlled oncolytic adenoviruses eliminate cancer stem cells in human pancreatic tumors.

    Science.gov (United States)

    Sobrevals, Luciano; Mato-Berciano, Ana; Urtasun, Nerea; Mazo, Adela; Fillat, Cristina

    2014-01-01

    Pancreatic tumors contain cancer stem cells highly resistant to chemotherapy. The identification of therapies that can eliminate this population of cells might provide with more effective treatments. In the current work we evaluated the potential of oncolytic adenoviruses to act against pancreatic cancer stem cells (PCSC). PCSC from two patient-derived xenograft models were isolated from orthotopic pancreatic tumors treated with saline, or with the chemotherapeutic agent gemcitabine. An enrichment in the number of PCSC expressing the cell surface marker CD133 and a marked enhancement on tumorsphere formation was observed in gemcitabine treated tumors. No significant increase in the CD44, CD24, and epithelial-specific antigen (ESA) positive cells was observed. Neoplastic sphere-forming cells were susceptible to adenoviral infection and exposure to oncolytic adenoviruses resulted in elevated cytotoxicity with both Adwt and the tumor specific AduPARE1A adenovirus. In vivo, intravenous administration of a single dose of AduPARE1A in human-derived pancreatic xenografts led to a remarkable anti-tumor effect. In contrast to gemcitabine AduPARE1A treatment did not result in PCSC enrichment. No enrichment on tumorspheres neither on the CD133(+) population was detected. Therefore our data provide evidences of the relevance of uPAR-controlled oncolytic adenoviruses for the elimination of pancreatic cancer stem cells. © 2013.

  18. Asynchronous machines. Direct torque control; Machines asynchrones. Commande par controle direct de couple

    Energy Technology Data Exchange (ETDEWEB)

    Fornel, B. de [Institut National Polytechnique, 31 - Toulouse (France)

    2006-05-15

    The asynchronous machine, with its low cost and robustness, is today the most widely used motor to make speed variators. However, its main drawback is that the same current generates both the magnetic flux and the torque, and thus any torque variation creates a flux variation. Such a coupling gives to the asynchronous machine a nonlinear behaviour which makes its control much more complex. The direct self control (DSC) method has been developed to improve the low efficiency of the scalar control method and for the specific railway drive application. The direct torque control (DTC) method is derived from the DSC method but corresponds to other type of applications. The DSC and DTC algorithms for asynchronous motors are presented in this article: 1 - direct control of the stator flux (DSC): principle, flux control, torque control, switching frequency of the inverter, speed estimation; 2 - direct torque control (DTC): principle, electromagnetic torque derivative, signals shape and switching frequency, some results, DTC speed variator without speed sensor, DTC application to multi-machine multi-converter systems; 3 - conclusion. (J.S.)

  19. The Radioisotopic Determination of Diffusion Coefficients and Currents in Natural Waters. Surface Collection of Radioactive Fall-Out on a Large Alpine Lake; Determination par detection nucleaire des coefficients de diffusion et des courants dans les eaux naturelles. Evolution de la surface de collection d'un grand lac alpin pour les retombees radioactives; Opredelenie koehffitsienta diffuzii i skorosti techeniya estestvennykh vod pri pomoshchi yadernogo detektirovaniya. Ehvolyutsiya poverkhnosti sbora radioaktivnykh osadkov na bol'shom al'pijskom ozere; Determinacion por deteccion nuclear de los coeficientes de difusion y de las corrientes en las aguas naturales evolucion de la superficie de captacion de un gran lago alpino para las precipitaciones radiactivas

    Energy Technology Data Exchange (ETDEWEB)

    Chesselet, R.; Nordemann, D. [Service d' Electronique Physique, Centre d' Etudes Nucleaires de Saclay (France); Dussart, B. [Centre de Recherches Hydrobiologiques, CNRS, Gif-sur-Yvette (France)

    1963-08-15

    In an initial stage, the authors brought about the in situ diffusion of a radioactive emitter (sodium-22, in the form of Na{sup +}) with very low activity, i.e. less than 1 mc. The diffusion laws applied in this case made it easy to predict the rate of diffusing of the {sup r}adioactive cloud{sup .} In this way, plotting the activities, as measured by two suitably placed gamma detectors, against time permits the estimation of a diffusion coefficient for the emitter used and, if appropriate, the measurement of current velocity at the point of measurement (in the case described, the Lake of Geneva). Subsequently, and in conjunction with a geophysical study on the general problem of radioactive fall-out, the authors worked on the increases in radioactive fall-out caused by nuclear tests in the atmosphere (October 1961 - January 1962). Measurements of radioactivity were made every day on samples of Lake Geneva water taken at depths of 0 m, 10 m and 20 m and also on a collector of dry and moist atmospheric fall-out. Despite the complex pattern, over a period, of theincreasesinfall-out , the interpretation of the diagrams obtained can help to explain what happens to radioactive products in the diffusion and current conditions encountered. The use of the diffusion of radioactive products in very small quantities and of the various highly sensitive techniques of nuclear detection now available can lead to a better understanding of in situ diffusion and of the movement of natural water masses. (author) [French] Dans un premiere etape, les auteurs ont provoque la diffusion in situ d'un emetteur radioactif, le sodium 22, sous forme de Na{sup +}, avec des activites tres faibles, inferieures au millicurie. Les lois de la diffusion appliquee a ce cas permettent aisement de prevoir l'allure du 'n'uage radioactif'' en cours de diffusion. Ainsi, l'enregistrement en fonction du temps des activites mesurees par deux detecteurs gamma convenablemen t disposes conduit a l'evaluation d

  20. A direct current amplifier with linear or logarithmic response; Amplificateur courant continu a reponse lineaire ou logarithmique

    Energy Technology Data Exchange (ETDEWEB)

    Ailloud, J; Chandanson, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1956-07-01

    The following paper examines the conditions governing the construction of an instrument with logarithmic response, capable of measuring currents between 10{sup -10} A and 10{sup -4} A. The development is described of a type of stabilised direct current amplifier, designed particularly to operate in a Pile control board, giving indications proportional either to the power, on to the log. of this power, and which may also be linked to an instrument for measuring reactivity. (author) [French] On examine dans ce qui suit les conditions qui president a la realisation d'un ensemble a reponse logarithmique, utilisable pour mesurer des courants compris entre 10{sup -10} A et 10{sup -4} A. On decrit la realisation d'un type d'amplificateur courant continu stable, destine plus specialement a fonctionner dans un tableau de commande de Pile, donnant des indications proportionnelles soit a la puissance, soit au logarithme de cette puissance et de plus associe avec un ensemble de mesure de reactivite. (auteur)

  1. Heterotic reduction of Courant algebroid connections and Einstein–Hilbert actions

    Energy Technology Data Exchange (ETDEWEB)

    Jurčo, Branislav, E-mail: jurco@karlin.mff.cuni.cz [Mathematical Institute, Faculty of Mathematics and Physics, Charles University, Prague 186 75 (Czech Republic); Vysoký, Jan, E-mail: vysoky@math.cas.cz [Institute of Mathematics of the Czech Academy of Sciences, Žitná 25, Prague 115 67 (Czech Republic); Mathematical Sciences Institute, Australian National University, Acton ACT 2601 (Australia)

    2016-08-15

    We discuss Levi-Civita connections on Courant algebroids. We define an appropriate generalization of the curvature tensor and compute the corresponding scalar curvatures in the exact and heterotic case, leading to generalized (bosonic) Einstein–Hilbert type of actions known from supergravity. In particular, we carefully analyze the process of the reduction for the generalized metric, connection, curvature tensor and the scalar curvature.

  2. Heterotic reduction of Courant algebroid connections and Einstein–Hilbert actions

    International Nuclear Information System (INIS)

    Jurčo, Branislav; Vysoký, Jan

    2016-01-01

    We discuss Levi-Civita connections on Courant algebroids. We define an appropriate generalization of the curvature tensor and compute the corresponding scalar curvatures in the exact and heterotic case, leading to generalized (bosonic) Einstein–Hilbert type of actions known from supergravity. In particular, we carefully analyze the process of the reduction for the generalized metric, connection, curvature tensor and the scalar curvature.

  3. Les accidents de la vie courante chez l'enfant à Dakar: à propos de ...

    African Journals Online (AJOL)

    Les accidents de la vie courante chez l'enfant à Dakar: à propos de 201 cas. Azhar Salim Mohamed, Aloïse Sagna, Mbaye Fall, Ndeye Aby Ndoye, Papa Alassane Mbaye, Aimé Lakh Fall, Alou Diaby, Oumar Ndour, Gabriel Ngom ...

  4. Broca Pars Triangularis Constitutes a “Hub” of the Language-Control Network during Simultaneous Language Translation

    Directory of Open Access Journals (Sweden)

    Stefan Elmer

    2016-09-01

    Full Text Available Until now, several branches of research have fundamentally contributed to a better understanding of the ramifications of bilingualism, multilingualism, and language expertise on psycholinguistic-, cognitive-, and neural implications. In this context, it is noteworthy to mention that from a cognitive perspective, there is a strong convergence of data pointing to an influence of multilingual speech competence on a variety of cognitive functions, including attention, short-term- and working memory, set shifting, switching, and inhibition. In addition, complementary neuroimaging findings have highlighted a specific set of cortical and subcortical brain regions which fundamentally contribute to administrate cognitive control in the multilingual brain, namely Broca’s area, the middle-anterior cingulate cortex, the inferior parietal lobe, and the basal ganglia. However, a disadvantage of focusing on group analyses is that this procedure only enables an approximation of the neural networks shared within a population while at the same time smoothing inter-individual differences. In order to address both commonalities (i.e., within group analyses and inter-individual variability (i.e., single-subject analyses in language control mechanisms, here I measured five professional simultaneous interpreters while the participants overtly translated or repeated sentences with a simple subject-verb-object structure. Results demonstrated that pars triangularis was commonly activated across participants during backward translation (i.e., from L2 to L1, whereas the other brain regions of the control network showed a strong inter-individual variability during both backward and forward (i.e., from L1 to L2 translation. Thus, I propose that pars triangularis plays a crucial role within the language-control network and behaves as a fundamental processing entity supporting simultaneous language translation.

  5. La mise en oeuvre des codes d'éthique par le control interne

    NARCIS (Netherlands)

    van der Elst, C.F.

    2014-01-01

    The real value of the internal control system lies in the animation of the ethical values in the organization. The integration of ethical risks in the internal control process enables the moving notions of ethical behaviour and accommodate the training and inducement programs of all employees

  6. Monitoreo de parásitos en efluentes domiciliarios Control of parasites in domestic sewage

    Directory of Open Access Journals (Sweden)

    Liliana Semenas

    1999-08-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.OBJETIVO: Avaliar a presença de parasitas em efluentes semi-sólidos e líquidos, em diferentes localidades da Patagonia argentina, por ser fato uma das restrições para seu uso. MÉTODOS: As amostras selecionadas de 4 Centros de Tratamento de Efluentes Domiciliários foram analisadas de acordo com as normas da "Environmental Protection Agenty", Organização Mundial da Saúde e do "Standard Methods for Examination of Water and Wastewater", além de algumas classificações. RESULTADOS: Somente 2 das 6 amostras de semi-sólidos analisadas continham ovos de Ascaris lumbricoides não viáveis. Das 10 amostras líquidas, somente 2 não continham ovos, enquanto as restantes continham patógenos das categorias I (Giardia sp., Hymenolepis diminuta e Enterobius

  7. Radio-controlled automatic gas meter-reading system; Releve automatique de compteur par radio

    Energy Technology Data Exchange (ETDEWEB)

    Yasui, M. [Osaka Gas Co., Ltd (Japan); Ishikawa, K.; Fujiwara, J. [Tokyo Gas Co., Ltd. (Japan); Ichihashi, T. [Toho Gas Co., Ltd. (Japan)

    2000-07-01

    In Japan, an automatic gas meter-reading system is in operation, also incorporating the functions of monitoring for abnormalities in gas use and remote-controlled emergency gas supply shutoff. This system has been realized by linking microcomputer-controlled gas meters(It's called 'Intelligent gas mater') equipped with automatic shutoff mechanism to the gas utility company operation center via communication lines. While the present system uses cable communication lines, we of Tokyo Gas Co., Ltd., Osaka Gas Co., Ltd. and Toho Gas Co., Ltd., have jointly developed a new system based on radio communication. This paper introduces this new system. While radio-controlled meter-reading systems are used in many countries around the world solely for automatic meter reading, our recently developed system is also capable of monitoring for abnormalities in gas use and remote-controlled emergency gas supply shutoff, thanks to its almost real-time two-way communication function. The new system can serve for a period of ten years without recharging. It is also characterized by its applicability as different systems according to purposes: 1) conventional automatic meter-reading system (terminal network control unit or T-NCU), 2) large-scale radio-controlled meter-reading system, and 3) portable terminal-type radio-controlled meter-reading system. (authors)

  8. Control optimo de par para maquinas SynRM aplicadas a vehiculo electrico

    OpenAIRE

    Trancho, Elena; Ibarra, E.; Arias, A.; Kortabarria, I.

    2017-01-01

    Las maquinas de reluctancia sincrona asistidas por imanes estan atrayendo un considerable interes como alternativa a las maquinas sıncronas de imanes permanentes para su uso en sistemas de propulsion de vehıculos electricos. El control optimo de estas maquinas (incluyendo operacion en debilitamiento de campo) puede resultar complejo, ya que estas son, por lo general, muy sensibles al fenomeno de la saturacion magnetica. En este articulo se trata su control, desde los reguladores hasta el prec...

  9. Star products on graded manifolds and α′-corrections to Courant algebroids from string theory

    Energy Technology Data Exchange (ETDEWEB)

    Deser, Andreas, E-mail: andreas.deser@itp.uni-hannover.de [Institut für Theoretische Physik and Riemann Center for Geometry and Physics, Leibniz Universität Hannover, Hannover (Germany)

    2015-09-15

    Courant algebroids, originally used to study integrability conditions for Dirac structures, have turned out to be of central importance to study the effective supergravity limit of string theory. The search for a geometric description of T-duality leads to Double Field Theory (DFT), whose gauge algebra is governed by the C-bracket, a generalization of the Courant bracket in the sense that it reduces to the latter by solving a specific constraint. Recently, in DFT deformations of the C-bracket and O(d, d)-invariant bilinear form to first order in the closed string sigma model coupling, α′ were derived by analyzing the transformation properties of the Neveu-Schwarz B-field. By choosing a particular Poisson structure on the Drinfel’d double corresponding to the Courant algebroid structure of the generalized tangent bundle, we are able to interpret the C-bracket and bilinear form in terms of Poisson brackets. As a result, we reproduce the α′-deformations for a specific solution to the strong constraint of DFT as expansion of a graded version of the Moyal-Weyl star product.

  10. Detection of {alpha} particles using semiconductors. Application to the control of plutonium extraction; Detection des particules {alpha} par semiconducteurs application au controle de l'extraction du plutonium

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-03-01

    A study is made of a particles produced by thick sources, using either diffused junction or surface barrier semiconductor detectors for controlling continuously the plutonium extraction process. For this, a presenting apparatus is described in which the solutions to be analyzed flow in contact with the detector protected by a thin mica membrane. A method is described which gives a precise recording of the spectra and which thus allows the separation of two or more {alpha} emitters present in the same solution. This method has been applied to the measurement of {sup 239}Pu in the the presence of {sup 241}Am with an accuracy of {+-}5 per cent. In the second part of the report is considered the detection of plutonium in solutions of {beta} - {gamma} emitting fission products. Pile-up is reduced by using a fast amplification chain associated to totally depleted thin detectors. Under these conditions a few mg of {sup 239}Pu can be detected in solutions of fission products having an activity of 100 curies/liter. A method is given for discriminating {alpha} and {beta} particles, it is based on the difference in the collection times for the charges liberated by these particles in the detector. (author) [French] On etudie la detection de particules {alpha} issues de sources epaisses par detecteurs semiconducteurs a jonction diffusee ou a barriere de surface pour le controle continu du procede d'extraction du plutonium. A cet effet on decrit un appareil presentateur dans lequel les solutions a analyser circulent au contact du detecteur protege par une membrane mince de mica. On decrit une methode qui permet par le trace precis des spectres de separer deux ou plusieurs emetteurs {alpha} presents dans une meme solution. Cette methode a ete appliquee a la mesure du {sup 239}Pu en presence de {sup 241}Am avec une precision de {+-} 5 pour cent. Dans la deuxieme partie on traite de la detection du plutonium dans des solutions de produits de fission emetteurs {beta} and {gamma}. On

  11. APE (state-oriented approach) centralized control procedures; Procedures de conduite APE (Approche Par Etats)

    Energy Technology Data Exchange (ETDEWEB)

    Astier, D. [FRAMATOME ANP, 92 - Paris-La-Defence (France); Depont, G. [Electricite de France (EDF/DPN), 93 - Saint-Denis (France); Van Dermarliere, Y. [Electricite de France (EDF/SEPTEN), 69 - Villeurbanne (France)

    2004-07-01

    This article presents the progressive implementation of the state-oriented approach (APE) for centralized control procedures in French nuclear power plants. The implementation began in the years 1982-83 and it concerned only the circuits involved in engineered safeguard systems such IS (safety injection), EAS (containment spray system) and GMPP (reactor coolant pump set). In 2003 the last PWR unit switched from the event oriented approach to APE for post-accidental situations.

  12. Plutonium titration by controlled potential coulometry; Dosage du plutonium par coulometrie a potentiel impose

    Energy Technology Data Exchange (ETDEWEB)

    Leguay, N.

    2011-07-01

    The LAMMAN (Nuclear Materials Metrology Laboratory) is the support laboratory of the CETAMA (Analytical Method Committee), whose two main activities are developing analytic methods, and making and characterizing reference materials. The LAMMAN chose to develop the controlled potential coulometry because it is a very accurate analytical technique which allows the connection between the quantity of element electrolysed to the quantity of electricity measured thanks to the Faraday's law: it does not require the use of a chemical standard. This method was first used for the plutonium titration and was developed in the Materials Analysis and Metrology Laboratory (LAMM), for upgrading its performances and developing it to the titration of other actinides. The equipment and the material used were developed to allow the work in confined atmosphere (in a glove box), with all the restrictions involved. Plutonium standard solutions are used to qualify the method, and in particular to do titrations with an uncertainty better than 0.1 %. The present study allowed making a bibliographic research about controlled potential coulometry applied to the actinides (plutonium, uranium, neptunium, americium and curium). A full procedure was written to set all the steps of plutonium titration, from the preparation of samples to equipments storage. A method validation was done to check the full procedure, and the experimental conditions: working range, uncertainty, performance... Coulometric titration of the plutonium from pure solution (without interfering elements) was developed to the coulometric titration of the plutonium in presence of uranium, which allows to do accurate analyses for the analyses of some parts of the reprocessing of the spent nuclear fuel. The possibility of developing this method to other actinides than plutonium was highlighted thanks to voltammetric studies, like the coulometric titration of uranium with a working carbon electrode in sulphuric medium. (author)

  13. Controle d'attitude d'un lanceur en phase atmospherique approche par applications gardiennes

    Science.gov (United States)

    Dubanchet, Vincent

    In a first phase, the modelling process underlines the presence of highly time varying parameters during the ascent, due to a fast mass variation along with propellant consumption. Linearizing the dynamical equations at six main flight instants yields linear time invariant models to be considered during control design. Each of them is to be stabilized by one control law, while respecting given specifications. The synthesis becomes even more complex when the bending modes are taken into account. Moreover, scheduling appears necessary to deal with the time variations. Indeed it is shown that no single gain setting is able to respect all the specifications along the trajectory. Furthermore, increasing complexity when modelling a whole launch vehicle pushes one to consider the model's errors and uncertainties. They represent a major issue in this study since it is asked to ensure the nominal performances in a robust fashion. Owing to their properties, guardian maps appear to be the most suitable tool to deal with such a problem of scheduling with robust performances. In light of this, the development of synthesis methods based on guardian maps is the main contribution of the project. It appears that actual state of the art in this field is focused on theoretical issues, whereas practical ones could be improved. Two approches are presented in the memoire. The first one is based on a graphical approach consisting in drawing the vanishing locus of guardian maps. A program using image analysis techniques is devised to check automatically which gain settings satisfy the constraints. The second one is based on an optimisation procedure involving guardian maps. Starting with the open loop system, the iterative process proposed ends up with a satisfactory gain setting for the closed-loop. These methods are tried and tested for the launch vehicle, with specifications from ASTRIUM-ST. Their practical application is motivated by the system complexity, the different kinds of

  14. Applied Technologies and Prospects of Conformance Control Treatments in China Technologies et perspectives pour l’amélioration du profil de balayage dans les champs pétroliers matures produits par injection d’eau en Chine

    Directory of Open Access Journals (Sweden)

    Liu Yuzhang

    2010-02-01

    Full Text Available China is the largest user of chemical-based conformance control treatments and a series of technologies have been successfully developed and deployed in recent years. This paper first shows the milestones of development and application of conformance control technologies in China. Then integrated conformance control technologies are reviewed followed by the lessons we have learned, and then a few major specific conformance control technologies are addressed, including tracer injection and channels explanation, potentiometric testing to identify areal sweep efficiency, Pressure Index (PI decisionmaking technology to select well candidate, complementary decision-making technology to select well candidate and design application parameters, and major chemicals for in-depth fluid diversion technologies. In addition, this paper also describes the principles and applications of some promising technologies of combined chemical-based conformance treatment with other EOR/IOR process, including the combination technology of surfactant and water shutoff, profile control and mini-scale surfactant flooding, acid treatment and profile control treatment. Finally, this paper summarizes the problems and challenges faced by mature water flooded oilfields in China. Based on recent well tests, tracer testing and interpretation, and previous water control treatment experience, it appears that channels or high permeability streaks are common in mature water flooded oilfields. Some research directions and promising technologies are suggested. La Chine est le plus grand utilisateur de méthodes chimiques pour l’amélioration du profil de balayage de l’eau pour l’exploitation des champs pétroliers matures. Toute une série de technologies y ont d’ailleurs été créées et déployées avec succès ces dernières années. Cet article commence par présenter les étapes du développement et de la mise en place de ces technologies de contrôle de profil en Chine

  15. Electron multiplier for the measurement of an ion current on a mass spectrometer; Multiplicateur d'electrons pour la mesure de courant d'ions sur un spectrometre de masse

    Energy Technology Data Exchange (ETDEWEB)

    Lohez, P; Nief, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1957-07-01

    The apparatus described is designed to measure weak ion currents received at the collector of a mass spectrometer. The report describes successively the study of electron paths in the multiplier by the method of analogy, using rubber membranes, and the practical details of construction of the apparatus. The variation with surface treatment of the secondary emission coefficient of the alloy CuBe containing 2 per cent Be, which makes up the dynodes, and the influence of the voltage on the gain per stage, are discussed. Results of tests regarding: the influence of the ion mass on the gain, the background of the instrument and the energy distribution of the impulses coming out on a high gain multiplier (q.q. 10{sup 7}) are given. Finally the performances of the multiplier are reported. 1- For a low gain (10{sup 4}), precision and reproducibility comparable to the electrometer valve, sensitivity 100 times greater, currents capable of detection 10{sup -17} Ampere. 2- For a high gain (10{sup 7}) and measurement by impulse counting, currents capable of detection 10{sup -19} Ampere. Mounting difficult to use on a mass spectrometer. (author) [French] L'appareil decrit est destine a la mesure des faibles courants d'ions re s au collecteur d'un spectrometre de masse. Le rapport decrit successivement l'etude des trajectoires des electrons dans le multiplicateur, par la methode analogique de la menbrane en caoutchouc, et la realisation pratique de l'appareil. La variation du coefficient d'emission secondaire de l'alliage CuBe a 2 pour cent de Be, constituant les dynodes suivant le traitement des surfaces, et l'influence de la tension sur le gain par etage sont discutees. Des resultats d'essais concernant: l'influence de la masse des ions sur le gain, le bruit de fond de l'appareil et la repartition en energie des impulsions de sortie sur un multiplicateur a gain eleve (q.q. 10{sup 7}) sont donnes. Enfin, sont rapportees les performances du multiplicateur. 1- pour un gain faible

  16. Direct digital control of furnaces irradiated in nuclear reactors; Surveillance et regulation multiplexee par calculateur numerique de fours irradies

    Energy Technology Data Exchange (ETDEWEB)

    Joumard, R [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    An experimental direct digital control system has been realised in the 'C.E.N.G.', in order to verify that a computer makes easier the control of the experiments done in the nuclear reactors and to solve the theoretical and technical difficulties. The regulation is applied to thermal processes. The sampled data systems theory permits to choose the type of an efficient and simple digital compensator, and to establish a diagram which gives the values of the correcting parameters (obtained by minimizing the difference between the output and the input when perturbations occur). The programme execute, in simultaneity, supervision and regulation. Complex possibilities of printing out measures and alarms existed. The computer works out an incremental correction which makes step motors to turn. These motors act on the heating organs. The theoretical values and answers have been confirmed. The accuracy was limited essentially by the input quantification (1/1000 th). The comfort of such a system has been noticeable. (author) [French] Une installation de controle numerique direct fut realisee a titre experimental au C.E.N.G pour verifier qu'un ordinateur rendait plus aisee l'exploitation des experiences faites en pile nucleaire et pour degager les difficultes theoriques et techniques. La regulation s'applique a des processus thermiques. La theorie des systemes echantillonnes a permis de choisir un type de correcteur numerique simple et efficace et d'etablir un abaque qui donne les valeurs des parametres correcteurs minimisant les ecarts enregistres entre la reponse et la consigne en presence de perturbations. Le programme effectuait simultanement de la surveillance et de la regulation. Une restitution complexe des informations et des alarmes sur machine a ecrire etait possible. Le calculateur elaborait une correction incrementielle qui faisait tourner des moteurs pas a pas, lesquels commandaient les organes de puissance de chauffage. Les valeurs et les reponses theoriques ont

  17. Direct digital control of furnaces irradiated in nuclear reactors; Surveillance et regulation multiplexee par calculateur numerique de fours irradies

    Energy Technology Data Exchange (ETDEWEB)

    Joumard, R. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    An experimental direct digital control system has been realised in the 'C.E.N.G.', in order to verify that a computer makes easier the control of the experiments done in the nuclear reactors and to solve the theoretical and technical difficulties. The regulation is applied to thermal processes. The sampled data systems theory permits to choose the type of an efficient and simple digital compensator, and to establish a diagram which gives the values of the correcting parameters (obtained by minimizing the difference between the output and the input when perturbations occur). The programme execute, in simultaneity, supervision and regulation. Complex possibilities of printing out measures and alarms existed. The computer works out an incremental correction which makes step motors to turn. These motors act on the heating organs. The theoretical values and answers have been confirmed. The accuracy was limited essentially by the input quantification (1/1000 th). The comfort of such a system has been noticeable. (author) [French] Une installation de controle numerique direct fut realisee a titre experimental au C.E.N.G pour verifier qu'un ordinateur rendait plus aisee l'exploitation des experiences faites en pile nucleaire et pour degager les difficultes theoriques et techniques. La regulation s'applique a des processus thermiques. La theorie des systemes echantillonnes a permis de choisir un type de correcteur numerique simple et efficace et d'etablir un abaque qui donne les valeurs des parametres correcteurs minimisant les ecarts enregistres entre la reponse et la consigne en presence de perturbations. Le programme effectuait simultanement de la surveillance et de la regulation. Une restitution complexe des informations et des alarmes sur machine a ecrire etait possible. Le calculateur elaborait une correction incrementielle qui faisait tourner des moteurs pas a pas, lesquels commandaient les organes de puissance de chauffage. Les valeurs

  18. Edge localized modes control by resonant magnetic perturbations; Controle des instabilites de bord par perturbations magnetiques resonantes

    Energy Technology Data Exchange (ETDEWEB)

    Nardon, E

    2007-10-15

    The present work is dedicated to one of the most promising methods of control of the ELMs (Edge Localized Modes), based on a system of coils producing Resonant Magnetic Perturbations (RMPs). Our main objectives are, on the one hand, to improve the physical understanding of the mechanisms at play, and on the other hand to propose a concrete design of ELMs control coils for ITER. In order to calculate and analyze the magnetic perturbations produced by a given set of coils, we have developed the ERGOS code. The first ERGOS calculation was for the DIII-D ELMs control coils, the I-coils. It showed that they produce magnetic islands chains which overlap at the edge of the plasma, resulting in the ergodization of the magnetic field. We have then used ERGOS for the modelling of the experiments on ELMs control using the error field correction coils at JET and MAST. In the case of JET, we have shown the existence of a correlation between the mitigation of the ELMs and the ergodization of the magnetic field at the edge, in agreement with the DIII-D result. In order to design the ELMs control coils for ITER we have used ERGOS intensively, taking the case of the DIII-D I-coils as a reference. Three candidate designs came out, which we presented at the ITER Design Review, in 2007. Recently, the ITER management decided to provide a budget for building ELMs control coils, the design of which remains to be chosen between two of the three options that we proposed. Finally, in order to understand better the non-linear magnetohydrodynamics phenomena taking place in ELMs control by RMPs, we performed numerical simulations, in particular with the JOREK code for a DIII-D case. The simulations reveal the existence of convection cells induced at the edge by the magnetic perturbations, and the possible screening of the RMPs in presence of rotation.

  19. Ultrasonic testing of canning tubes in stainless steel of the EL 4 reactor; Controle par ultrasons des tubes de gaine en acier inoxydable du reacteur EL 4

    Energy Technology Data Exchange (ETDEWEB)

    Prot, A; Monnier, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    From all the methods possible for controlling thin cans the one chosen, for numerous reasons, vas that making use of ultrasonic techniques. A method has been developed which should make it possible to carry out a rapid and efficient industrial control of canning tubes, The reasons for the choice of the ultrasonic method are given in detail, together with the principles of the method and the actual control parameters. In the present state of our research, it should be possible to control at least 50 000 tubes a year. Improvements brought about in the details of the control technique itself should make it possible to increase this rate considerably. (authors) [French] Parmi toutes les methodes possibles de controle des gaines minces, le procede retenu pour de multiples raisons a ete celui faisant appel a la technique des ultrasons. Une methode a ete mise au point qui doit permettre un controle industriel rapide et efficace des tubes de gaine. Sont exposes en detail, les raisons du choix de la methode par ultrasons, les principes de cette methode et les parametres du controle proprement dit. Dans l'etat actuel de nos etudes la cadence devrait permettre le controle de 50000 tubes par an au minimum. Des ameliorations de detail portant sur la technique de controle elle-meme, doivent permettre d'accelerer tres notablement cette cadence. (auteurs)

  20. Étude de la répartition des courants de Foucault pulsés dans une configuration de contrôle non destructif

    Science.gov (United States)

    Bour, J.-C.; Zubiri, E.; Vasseur, P.; Billat, A.

    1996-01-01

    Adjusting an experimental device of control by eddy-currents in sinusoidal or pulse mode requires the optimization of a certain number of parameters. Generally, the implementation of the latter operations is long and delicate, since it is issued of many compromises. The simulation study presented in this paper can be considered as a qualitative help because it specifies the the behaviour of the different parameters implied in the adjustment of the experimental defect reserach. First, we prove the influence of the lift-off on the defect detention's sensitivity of the flat sensor we used. Next we give prominence to the fact, in practice, we cannot disregard the geometry of the sensor, as we could do in theory. This result will lead us to define a family of curves showing the evolution of the depth of penetration as a function of the pulse's duration for different coil radii. We also determine the maximal sensor's sensitivity area, with the aim of locating the defect detected in the plate with precision. Finally, we prove the dependency between the true value of the depth of penetration and the thickness of the considered metallic plate. This very important result should equally be taken under consideration in the case of a real control. La mise au point d'un dispositif expérimental de contrôle par courants de Foucault, en mode sinusoïdal ou impulsionnel, nécessite l'optimisation d'un certain nombre de paramètres. Cette optimisation est généralement longue et délicate à exécuter en pratique puisqu'elle résulte de plusieurs compromis. L'étude en simulation présentée ici peut être considéré comme une aide plutôt qualitative, puisqu'elle précise le comportement des différents paramètres impliqués dans la mise en point de la recherche expérimentale de défauts. Nous montrons dans un premier temps l'influence de la distance capteur-cible sur la sensibilité du capteur à détecter un défaut. Nous mettons ensuite en évidence le fait de la g

  1. Calculation of pole profiles for the design of particle accelerators magnets. Equivalent current and conformal representation methods; Calcul de profils polaires destines a des aimants d'accelerateurs de particules. Methode des courants et methode des transformations conformes

    Energy Technology Data Exchange (ETDEWEB)

    Jaidane, S [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-04-01

    These two methods allow the determination of the shape of the poles in magnets, for a given field distribution in the air-gap. First method: The principle of the method consists to create the desired law of field by means of current sheets in which one can adjust the density given in a polynomial form. For the right distribution of these currents, the equipotential corresponding to the magnetic potential of the excitation coils is calculated. The pole profile of the H or C magnet identified with this equipotential line will finally take the place of the distribution of the current sheets used in the calculation. Steel permeability is assumed to be infinite and Foucault current effects are neglected in the case of variable fields. Second method: It consists to find a conformal representation that maps the pole profile plane upon the upper half of another plane where the equipotentials are two half straight lines, and where the field problems are easier to solve. Steel permeability is also considered to be infinite and the coils far from the pole faces. This known method has been applied to be compared with the first one. (author) [French] Ces deux methodes consistent a determiner la forme des pieces polaires d'aimants pour une distribution de champ determinee a l'avance dans l'entrefer. Premiere methode: Le principe de la methode consiste a creer la loi de champ desiree par l'intermediaire de nappes de courant dont on peut ajuster la densite exprimee sous une forme polynominale. Pour une distribution convenable de ces courants, on calcule l'equipotentielle correspondant au potentiel magnetique des bobines d'excitation. Le profil polaire d'un aimant en H ou C identifie a l'equipotentielle se substitue finalement a la repartition des nappes de courant utilisee dans la methode de calcul. La permeabilite de l'acier est supposee infinie et les courants de Foucault sont negliges dans le cas des champs variables. Seconde methode: Elle consiste a trouver une transformation

  2. Optimal Parameter Updating in Assisted History Matching Using Streamlines as a Guide Mise à jour optimale des paramètres dans un processus de calage d’historique en s’aidant des lignes de courants

    Directory of Open Access Journals (Sweden)

    Kazemi A.

    2013-05-01

    paramètres n’ont pas la même importance, et identifier les zones du réservoir où les paramètres doivent être mis à jour est un défi. Dans cette étude, nous étudions les méthodes de calage d’historique en nous concentrant sur les sous-ensembles des paramètres du modèle, et nous utilisons les lignes de courant pour choisir les zones du modèle qui doivent être modifiées. Nous identifions les régions du réservoir affectant des puits particuliers et nous y ajustons les propriétés du réservoir (fraction de roche réservoir et perméabilité. Les changements sont réalisés à partir de la méthode des points pilotes associée à un algorithme d’optimisation par voisinage. Nous appliquons cette méthodologie au champ Nelson (North Sea, UK pour lequel les prévisions de production dépendent de l’incertitude sur la distribution des argiles. Le champ est divisé en régions sur la base des performances des plus mauvaises prédictions aux puits. Nous forçons les modèles de réservoir à respecter les historiques de production pour améliorer les taux de production. Les régions nécessitant des changements sont suffisamment distinctes pour que nous puissions les modifier une à la fois. Nous comparons également nos résultats à une approche plus ad hoc qui implique la modification de toute la zone autour du puits. Nous observons que, pour les puits d’intérêt, l’approche guidée par les lignes de courant amène à une amélioration de 70 % du calage des données de production comparé au modèle de départ et à une réduction d’environ 40 % des écarts pour les prévisions. Cette amélioration est deux fois plus élevée que celle apportée par une modification des propriétés tout autour du puits.

  3. Guide d'exploitation des filières de traitement par boues activées

    OpenAIRE

    Boutin, C.; Caquel, O.; Dimastromatteo, N.,; Dumaine, J.,; Fernandes. G.,; Gervasi, C.; Parotin, S.; Prost Boucle, S.; Tscherter, C.

    2015-01-01

    / Ce guide, à destination des maîtres d'ouvrage et des exploitants, a pour objet de présenter de façon synthétique, les modalités d'exploitation courante d'une station d'épuration par boues activées de capacité < 600 kg DBO5/jour (soit 10 000 équivalents habitants (EH)), et dimensionnée dans le domaine de charge de l'aération prolongée (Cm < 0,1 kg DBO5 /kg MVS/jour). Conçu au fil de l'eau, il recense, tant pour la file eau que pour la file boues, l'ensemble des tâches d'exploitation courante...

  4. Analysis of electronic circuits using digital computers; L'analyse des circuits electroniques par les calculateurs numeriques

    Energy Technology Data Exchange (ETDEWEB)

    Tapu, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    Various programmes have been proposed for studying electronic circuits with the help of computers. It is shown here how it possible to use the programme ECAP, developed by I.B.M., for studying the behaviour of an operational amplifier from different point of view: direct current, alternating current and transient state analysis, optimisation of the gain in open loop, study of the reliability. (author) [French] Differents programmes ont ete proposes pour l'etude des circuits electroniques a l'aide des calculateurs. On montre comment on peut utiliser le programme ECAP, mis au point par I. B. M., pour etudier le comportement d'un amplificateur operationnel, a differents points de vue: analyse en courant continu, courant alternatif et regime transitoire, optimalisation du gain en boucle ouverte, etude de la fiabilite. (auteur)

  5. Datation de la grossesse en pratique courante au Cameroun: fiabilité de la date de dernières règles

    Science.gov (United States)

    Ngowa, Jean Dupont Kemfang; Mando, Emmanuel; Guegang, Emilienne; Ngassam, Anny; Kasia, Jean Marie

    2014-01-01

    Introduction La détermination précise de l’âge gestationnel (AG) est essentielle pour un suivi adapté de la grossesse. La date de dernières règles (DDR) et l’échographie de datation du premier trimestre sont les moyens habituels de datation de la grossesse. La DDR est souvent imprécise du fait des erreurs de rappel ou d'un trouble du cycle menstruel. Cette étude transversale et descriptive avait pour objectif d’évaluer la fiabilité de la DDR dans la datation de la grossesse en pratique courante à Yaoundé. Méthodes Etude transversale et descriptive réalisée dans deux hôpitaux universitaires de Yaoundé du 15 décembre 2012 au 15 avril 2013. La collecte des données était effectuée par un interrogatoire des femmes enceintes au cours de la consultation prénatale et l'examen de leur dossier médical. Les femmes enceintes présentant une complication du premier trimestre (menace d'avortement, grossesse arrêtée ou extra-utérine, grossesse molaire) et celles ne se rappelant pas de leur DDR ont été exclues de l’étude. Les données étaient saisies dans Epi-Data 3.1 et analysées dans le logiciel SPSS. 21. Résultats Cinq cent huit femmes enceintes ont été enrôlées dans cette étude, 267(52,56%) d'entre elles avaient noté leur DDR sur un support tandis que 241(47,44%) utilisaient leur mémoire pour se rappeler leur DDR. Cent dix-sept (23,03%) femmes enceintes avait réalisé une échographie de datation du premier trimestre et parmi elles, 50 (42,70%) avaient une discordance des âges gestationnels théorique et échographique. Le rappel de la DDR par la mémoire (OR. 3,46; IC: 1,59-7,53), le cycle irrégulier (OR. 6,15; IC: 1,24-30,4) et le doute sur la DDR communiquée (OR. 31,06; IC: 3.95-244) étaient les facteurs significativement associés à la discordance des AG théorique et échographique. Conclusion La DDR utilisée pour la datation de la grossesse en pratique courante à Yaoundé est fréquemment imprécise. PMID:25309664

  6. Integración de prácticas culturales y control biológico para el manejo de Moniliophthora roreri Cif & Par

    Directory of Open Access Journals (Sweden)

    Jorge Enrique Villamil

    2015-12-01

    Full Text Available En Colombia las pérdidas ocasionadas por Moniliophthora roreri Cif & Par en el cultivo de cacao, son considerables y los métodos de control tradicional no son suficientes. Para el manejo de la enfermedad el control biológico, surge como alternativa económicamente viable y ambientalmente sostenible. El objetivo del presente estudio fue evaluar el control de Moniliophthora roreri mediante parámetros de incidencia y severidad, utilizando aislamientos nativos y cepas comerciales de Trichoderma spp., en combinación con prácticas culturales (PC. Se evaluaron diez tratamientos, los cuales resultaron de combinar prácticas culturales, productos biológicos comerciales, aislamientos nativos de hongos y funguicidas de síntesis química. Para la evaluación, se empleó un diseño completamente aleatorio (DCA con cuatro repeticiones, para un total de 40 UE cada una compuesta por una planta del clon TCS01 (Theobroma CORPOICA la Suiza 01. Se hizo inoculación dirigida al dosel, utilizando una concentración de 1,2, 1,5 y 2,9 x107 UFC.g-1 para aislamientos nativos y 2,0 y 5,0 x108 UFC.g-1 para cepas comerciales. Se evaluó incidencia y severidad externa en los frutos durante 25 semanas. Los resultados indicaron que los frutos inoculados con el tratamiento T7 (P.C + Safer soil ®W.P y T4 (P.C + mezcla Trichoderma H20, H3, H5, presentaron los menores porcentajes de incidencia y severidad externa y los mayores rendimientos de cosecha sin diferencias significativas respecto al control químico y regional, representando una alternativa promisoria para la producción de cacao en la subregión occidental de Boyacá.

  7. Étude de la réponse en courant de détecteurs silicium opérés en environnement de très hautes radiations

    CERN Document Server

    Roy, Patrick

    Ce travail se situe dans le cadre de l'expérience ATLAS auprès du Grand Collisionneur Hadronique (LHC) qui sera construit au CERN. Il consiste en l'étude de la réponse en courant de détecteurs au silicium de grande surface, irradiés par des neutrons ou des protons de façon à reproduire l'environnement de hautes radiations auquel le détecteur ATLAS devra faire face. A l'aide d'une modélisation du transport des charges produites par le passage de particules alpha ou bêta dans un détecteur au silicium et d'un ensemble de données expérimentales, il est possible d'obtenir certaines caractéristiques électriques importantes des détecteurs. Ces caractéristiques sont: la concentration effective de dopants (ce qui détermine la tension de désertion d'un semi-conducteur), le piégeage des porteurs de charge (donnant l'efficacité de la collection des charges), et les mobilités des électrons et des trous (influençant le temps nécessaire à la collection des charges). En connaissant l'évolution de...

  8. Effectiveness of the EMPOWER-PAR Intervention in Improving Clinical Outcomes of Type 2 Diabetes Mellitus in Primary Care: A Pragmatic Cluster Randomised Controlled Trial.

    Science.gov (United States)

    Ramli, Anis Safura; Selvarajah, Sharmini; Daud, Maryam Hannah; Haniff, Jamaiyah; Abdul-Razak, Suraya; Tg-Abu-Bakar-Sidik, Tg Mohd Ikhwan; Bujang, Mohamad Adam; Chew, Boon How; Rahman, Thuhairah; Tong, Seng Fah; Shafie, Asrul Akmal; Lee, Verna K M; Ng, Kien Keat; Ariffin, Farnaza; Abdul-Hamid, Hasidah; Mazapuspavina, Md Yasin; Mat-Nasir, Nafiza; Chan, Chun W; Yong-Rafidah, Abdul Rahman; Ismail, Mastura; Lakshmanan, Sharmila; Low, Wilson H H

    2016-11-14

    The chronic care model was proven effective in improving clinical outcomes of diabetes in developed countries. However, evidence in developing countries is scarce. The objective of this study was to evaluate the effectiveness of EMPOWER-PAR intervention (based on the chronic care model) in improving clinical outcomes for type 2 diabetes mellitus using readily available resources in the Malaysian public primary care setting. This was a pragmatic, cluster-randomised, parallel, matched pair, controlled trial using participatory action research approach, conducted in 10 public primary care clinics in Malaysia. Five clinics were randomly selected to provide the EMPOWER-PAR intervention for 1 year and another five clinics continued with usual care. Patients who fulfilled the criteria were recruited over a 2-week period by each clinic. The obligatory intervention components were designed based on four elements of the chronic care model i.e. healthcare organisation, delivery system design, self-management support and decision support. The primary outcome was the change in the proportion of patients achieving HbA1c diabetes mellitus patients were recruited at baseline (intervention: 471 vs. 417). At 1-year, 96.6 and 97.8% of patients in the intervention and control groups completed the study, respectively. The baseline demographic and clinical characteristics of both groups were comparable. The change in the proportion of patients achieving HbA1c target was significantly higher in the intervention compared to the control group (intervention: 3.0% vs. -4.1%, P diabetes in the Malaysian public primary care setting. Registered with: ClinicalTrials.gov.: NCT01545401 . Date of registration: 1st March 2012.

  9. Archimedes in the 21st Century : World Conference at the Courant Institute of Mathematical Sciences

    CERN Document Server

    2017-01-01

    This book is a collection of papers presented at the “Archimedes in the 21st Century” world conference, held at the Courant Institute of Mathematical Sciences in 2013. This conference focused on the enduring and continuing influence of Archimedes in our modern world, celebrating his centuries of influence on mathematics, science, and engineering.  Archimedes planted the seeds for a myriad of seminal ideas that would grow over the ages. Each chapter surveys the growth of one or more of these seeds, and the fruit that they continue to bear to this day. The conference speakers contributing to this book are actively involved in STEM fields whose origins trace back to Archimedes, many of whom have conducted and published research that extends Archimedes’ work into the 21st century. The speakers are not historians, so while historical context is provided, this book is uniquely focused on the works themselves as opposed to their history.   The breadth and depth of Archimedes’ influence will inspire, deligh...

  10. Enforcing the Courant-Friedrichs-Lewy condition in explicitly conservative local time stepping schemes

    Science.gov (United States)

    Gnedin, Nickolay Y.; Semenov, Vadim A.; Kravtsov, Andrey V.

    2018-04-01

    An optimally efficient explicit numerical scheme for solving fluid dynamics equations, or any other parabolic or hyperbolic system of partial differential equations, should allow local regions to advance in time with their own, locally constrained time steps. However, such a scheme can result in violation of the Courant-Friedrichs-Lewy (CFL) condition, which is manifestly non-local. Although the violations can be considered to be "weak" in a certain sense and the corresponding numerical solution may be stable, such calculation does not guarantee the correct propagation speed for arbitrary waves. We use an experimental fluid dynamics code that allows cubic "patches" of grid cells to step with independent, locally constrained time steps to demonstrate how the CFL condition can be enforced by imposing a constraint on the time steps of neighboring patches. We perform several numerical tests that illustrate errors introduced in the numerical solutions by weak CFL condition violations and show how strict enforcement of the CFL condition eliminates these errors. In all our tests the strict enforcement of the CFL condition does not impose a significant performance penalty.

  11. Control of the subthalamic innervation of substantia nigra pars reticulata by D1 and D2 dopamine receptors.

    Science.gov (United States)

    Ibañez-Sandoval, Osvaldo; Hernández, Adán; Florán, Benjamin; Galarraga, Elvira; Tapia, Dagoberto; Valdiosera, Rene; Erlij, David; Aceves, Jorge; Bargas, José

    2006-03-01

    The effects of activating dopaminergic D1 and D2 class receptors of the subthalamic projections that innervate the pars reticulata of the subtantia nigra (SNr) were explored in slices of the rat brain using the whole cell patch-clamp technique. Excitatory postsynaptic currents (EPSCs) that could be blocked by 6-cyano-7-nitroquinoxalene-2,3-dione and D-(-)-2-amino-5-phosphonopentanoic acid were evoked onto reticulata GABAergic projection neurons by local field stimulation inside the subthalamic nucleus in the presence of bicuculline. Bath application of (RS)-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride (SKF-38393), a dopaminergic D1-class receptor agonist, increased evoked EPSCs by approximately 30% whereas the D2-class receptor agonist, trans-(-)-4aR-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrazolo(3,4-g)quinoline (quinpirole), reduced EPSCs by approximately 25%. These apparently opposing actions were blocked by the specific D1- and D2-class receptor antagonists: R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H-3-benzazepinehydrochloride (SCH 23390) and S-(-)-5-amino-sulfonyl-N-[(1-ethyl-2-pyrrolidinyl)-methyl]-2-methoxybenzamide (sulpiride), respectively. Both effects were accompanied by changes in the paired-pulse ratio, indicative of a presynaptic site of action. The presynaptic location of dopamine receptors at the subthalamonigral projections was confirmed by mean-variance analysis. The effects of both SKF-38393 and quinpirole could be observed on terminals contacting the same postsynaptic neuron. Sulpiride and SCH 23390 enhanced and reduced the evoked EPSC, respectively, suggesting a constitutive receptor activation probably arising from endogenous dopamine. These data suggest that dopamine presynaptically modulates the subthalamic projection that targets GABAergic neurons of the SNr. Implications of this modulation for basal ganglia function are discussed.

  12. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events ...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....

  13. Chromatographie à contre-courant simulé : développements et perspectives From Batch Elution to Simulated Countercurrent Chromatography

    Directory of Open Access Journals (Sweden)

    Hotier G.

    2006-11-01

    Full Text Available Les applications industrielles et le principe de fonctionnement du procédé de séparation en lit mobile ou en contre-courant simulé sont brièvement rappelés. La réalisation pratique de trois unités pilotes fonctionnant selon ce principe mais employant une technologie innovante est présentée. Cette mise en oeuvre particulière permet de tester par un simple changement de paramètres de contrôle toutes les configurations possibles de l'unité. Cet appareillage particulièrement souple est donc véritablement multitâche, ce qui permet en plus des applications en pétrochimie son emploi dans les domaines de la pharmacie, de la chimie fine et des bioséparations, où existe un grand nombre d'applications potentielles très différentes les unes des autres. Deux exemples de séparations réalisées à l'Institut Français du Pétrole sont succinctement présentés. La conclusion de ces essais est que la modélisation de ces procédés est indispensable pour pouvoir opérer correctement ce type d'unité. Une comparaison entre la chromatographie d'élution et cette technique de séparation ainsi que quelques propositions d'amélioration du procédé permettront au lecteur de se faire une idée sur l'extension potentielle de ce type de séparation. Distillation is and will for quite a long time remain the main separation technique in the refining, petrochemical and chemical industries. Some separations however cannot be performed by distillation when the products to be separated are subject to thermal degradation or when their boiling points are too close. Under these circumstances adsorption or chromatographic processes are interesting alternatives. In the 1960's and in the early 1970's the technology of the simulated moving bed, the UOP rotary valve and the application of these devices to separation processes were introduced by UOP. Nowadays simulated moving bedor countercurrentseparation processes may be found in the petrochemical industry

  14. Intense pulsed sources of ions and electrons produced by lasers; Sources pulsees intenses d'ions et d'electrons produites par laser

    Energy Technology Data Exchange (ETDEWEB)

    Bourrabier, G [Centre de Recherche de la C.S.F., Corbeville (France); Consoli, T; Slama, L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-11-01

    We describe a device for the acceleration of the plasma burst produced by focusing a laser beam into a metal target. We extract the electrons and the ions from the plasma. The maximum current is around 2000 amperes during few microseconds. The study of the effect of the kind of the target on the characteristics of the current shows the great importance of the initial conditions that is the ionisation potential of the target and the energy laser. (authors) [French] On decrit un dispositif destine a accelerer la bouffee de plasma produite par focalisation d'un faisceau laser sur une cible solide. On extrait du plasma les electrons et les ions. Le courant maximum atteint pres de 2000 amperes pendant quelques microsecondes. L'etude de l'effet de la nature de la cible sur les caracteristiques du courant collecte, met en evidence l'importance des conditions initiales (potentiel d'ionisation de la cible, energie du laser). (auteurs)

  15. Aplicación de algoritmos de control clásico, adaptable y robusto a sistemas dinámicos de parámetros variables;Classic, adaptable and robust control algorithm application, to variant parameter dynamic system.

    Directory of Open Access Journals (Sweden)

    Orlando – Regalón Anias

    2012-11-01

    Full Text Available Existen múltiples sistemas dinámicos cuyos modelos matemáticos se caracterizan por ser de primer orden yparámetros variables con el tiempo. En estos casos las herramientas clásicas no siempre logran un sistema decontrol que sea estable, posea un buen desempeño dinámico y rechace adecuadamente las perturbaciones, cuandoel modelo de la planta se desvía del nominal, para el cual se realizó el diseño.En este trabajo se evalúa elcomportamiento de tres estrategias de control en presencia de variación de parámetros. Estas son: control clásico,control adaptable y control robusto. Se realiza un estudio comparativo de las mismas en cuanto a complejidad deldiseño, costo computacional de la implementación y sensibilidad ante variaciones en los parámetros y/o presencia dedisturbios. Se llega a conclusiones que permiten disponer de criterios para la elección más adecuada, endependencia de los requerimientos dinámicos que la aplicación demande, así como de los medios técnicos de que sedisponga.Many dynamic systems have first order mathematic models, with time variable parameters. In these cases, theclassical tools do not satisfy at all control system stability, good performance and perturbation rejection, when theplant model differs from the nominal one, for which the controller was designed.In this article, three control strategiesare evaluated in parameter variations and disturbance presence. The strategies are the followings: classical control,adaptive control and robust control. A comparative study is carried out, taking into account the design complexity, thecomputational cost and the sensitivity. The obtained conclusions helps to provide the criterion to choose the mostadequate control strategy, according to the necessary dynamic, as well as the available technical means.

  16. Par Pond water balance

    International Nuclear Information System (INIS)

    Hiergesell, R.A.; Dixon, K.L.

    1996-06-01

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  17. Aplicación de algoritmos de control clásico, adaptable y robusto a sistemas dinámicos de parámetros variables; Classic, adaptable and robust control algorithm application, to variant parameter dynamic system

    Directory of Open Access Journals (Sweden)

    Orlando Regalón Anias

    2012-11-01

    Full Text Available Existen múltiples sistemas dinámicos cuyos modelos matemáticos se caracterizan por ser de primer orden y parámetros variables con el tiempo. En estos casos las herramientas clásicas no siempre logran un sistema decontrol que sea estable, posea un buen desempeño dinámico y rechace adecuadamente las perturbaciones, cuando el modelo de la planta se desvía del nominal, para el cual se realizó el diseño.En este trabajo se evalúa el comportamiento de tres estrategias de control en presencia de variación de parámetros. Estas son: control clásico, control adaptable y control robusto. Se realiza un estudio comparativo de las mismas en cuanto a complejidad del diseño, costo computacional de la implementación y sensibilidad ante variaciones en los parámetros y/o presencia de disturbios. Se llega a conclusiones que permiten disponer de criterios para la elección más adecuada, en dependencia de los requerimientos dinámicos que la aplicación demande, así como de los medios técnicos de que se disponga.  Many dynamic systems have first order mathematic models, with time variable parameters. In these cases, the classical tools do not satisfy at all control system stability, good performance and perturbation rejection, when the plant model differs from the nominal one, for which the controller was designed.In this article, three control strategies are evaluated in parameter variations and disturbance presence. The strategies are the followings: classical control, adaptive control and robust control. A comparative study is carried out, taking into account the design complexity, the computational cost and the sensitivity. The obtained conclusions helps to provide the criterion to choose the mostadequate control strategy, according to the necessary dynamic, as well as the available technical means.

  18. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. Foo......, results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...

  19. Progress report No. 53, October 1, 1976--September 30, 1977. [Courant Mathematics and Computing Laboratory, New York University

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-12-01

    Work in the following areas is considered in this annual report: applied mathematics (partial differential equations) in computational fluid dynamics, numerical analysis, etc.; computational physics and chemistry (partial differential equations); programing languages and compilers and other applications of computer science; and network access methods and applications of the ARPA network. Also discussed is the relation of work done at the Courant Institute to other projects, systems programing and user services, seminars, and publications. Individual reports are a paragraph or so in length. Completed work is reported in the appropriate publications. (RWR)

  20. Detection of {alpha} particles using semiconductors. Application to the control of plutonium extraction; Detection des particules {alpha} par semiconducteurs application au controle de l'extraction du plutonium

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-03-01

    A study is made of a particles produced by thick sources, using either diffused junction or surface barrier semiconductor detectors for controlling continuously the plutonium extraction process. For this, a presenting apparatus is described in which the solutions to be analyzed flow in contact with the detector protected by a thin mica membrane. A method is described which gives a precise recording of the spectra and which thus allows the separation of two or more {alpha} emitters present in the same solution. This method has been applied to the measurement of {sup 239}Pu in the the presence of {sup 241}Am with an accuracy of {+-}5 per cent. In the second part of the report is considered the detection of plutonium in solutions of {beta} - {gamma} emitting fission products. Pile-up is reduced by using a fast amplification chain associated to totally depleted thin detectors. Under these conditions a few mg of {sup 239}Pu can be detected in solutions of fission products having an activity of 100 curies/liter. A method is given for discriminating {alpha} and {beta} particles, it is based on the difference in the collection times for the charges liberated by these particles in the detector. (author) [French] On etudie la detection de particules {alpha} issues de sources epaisses par detecteurs semiconducteurs a jonction diffusee ou a barriere de surface pour le controle continu du procede d'extraction du plutonium. A cet effet on decrit un appareil presentateur dans lequel les solutions a analyser circulent au contact du detecteur protege par une membrane mince de mica. On decrit une methode qui permet par le trace precis des spectres de separer deux ou plusieurs emetteurs {alpha} presents dans une meme solution. Cette methode a ete appliquee a la mesure du {sup 239}Pu en presence de {sup 241}Am avec une precision de {+-} 5 pour cent. Dans la deuxieme partie on traite de la detection du plutonium dans des solutions de produits de fission emetteurs {beta} and {gamma

  1. It's quicker "Par Avignon"!

    CERN Multimedia

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  2. Essais sur la production de l'hydrogène solaire par électrolyse de l'eau

    OpenAIRE

    Ben Slama , Romdhane

    2007-01-01

    International audience; L'intérêt accru aux combustibles nécessite la diversification de leur approvisionnement, et ce, surtout à une époque où le prix du baril a doublé en trois ans pour atteindre un record de 75 $/baril. Ce papier présente un début de travail sur la production de l'hydrogène par électrolyse de l'eau. Le courant nécessaire est fourni par un module photovoltaïque. Les expériences ont permis de déterminer les paramètres à optimiser pour des meilleures performances : il s'agit ...

  3. Aplicación de Antagonistas Microbianos para el Control Biológico de Moniliophthora roreri Cif & Par en Theobroma cacao L. Bajo Condiciones de Campo / Application of Microbial Antagonists for the Biological Control of Moniliophthora roreri Cif & Par in

    Directory of Open Access Journals (Sweden)

    Jorge Enrique Villamil Carvajal

    2014-12-01

    Full Text Available Resumen. En Colombia, las pérdidas ocasionadas porMoniliophthora roreri Cif & Par en el cultivo de cacao continúansiendo considerables. El objetivo del presente estudio fue investigarla actividad antagónica de dos aislamientos autóctonos deTrichoderma sp. y uno de Bacillus sp. ante M. roreri, en condicionesde campo. Los tratamientos fueron: T1, hongo H5; T2, hongo H20;T3, bacteria B3 y T4, testigo. Se evaluó incidencia y severidadexterna e interna en los frutos. Los resultados de severidad externae interna mostraron que respecto al control la disminucióndel daño en los frutos fue del 19,5 y 11,2% en el T1, del 28 y19,5% en el T2 y del 13,5 y 8,5% en el T3, respectivamente condiferencias estadísticas a favor del T2. Se concluye que entre lostres antagonistas evaluados, el hongo H20 (Trichoderma sp. tieneel mayor potencial para el control de la moniliasis del cacao encondiciones de campo. / Abstract. In Colombia, the economic losses caused byMoniliophthora roreri Cif & Par in the cocoa cultivation continuebeing considerable. The objective of this study was to investigatethe antagonistic activity of two indigenous isolates of Trichodermasp and one of Bacillus sp. over M. roreri under field conditions. Thetreatments were: T1, fungus H5; T2, fungus H20; T3, bacteria B3; T4,control. The variables evaluated on the cocoa fruits were incidenceand external and internal severity. The results of the externaland internal severity showed that with respect to the control thedamage reduction on the cocoa fruits was 19,5 and 11,2% in T1,28 and 19,5% in T2, and 13,5 and 8,5% in T3, respectively withstatistical differences in favor of T2. It is concluded that amongthe three evaluated antagonists, the fungus H20 (Trichoderma sp.has the greatest potential for the biocontrol of frosty pod rot in thecocoa cultivation under field conditions.

  4. The controlled of the materials by the method of oscillation at the reactor core of Chatillon; Le controle des materiaux par la methode d'oscillation a la pile de Chatillon

    Energy Technology Data Exchange (ETDEWEB)

    Breton, D [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1955-07-01

    Nuclear controls has for aim to determine the validity of materials intended to be used for the construction of the reactor core. The cross-section of capture of these materials has to be measured while comparing them either to a standard of the same material, either to an element of cross-section supposed known. We studied the disruption of the working of the reactor generated by the periodic introduction of a sample of the studied material. This method is based on the measure of the phase angle of the signal provided by the ionization chamber. This signal results from the composition of a local signal and an aggregate signal due to the effects of diffusion and capture. This method permits the comparison of the capture of 2 samples very dispersive and few capturing as the graphite, the beryllium, the beryllium oxide, with a good precision. It permits to determine the cross-section of capture of elements as magnesium or aluminum. (M.B.) [French] Le controle nucleaire a pour but de determiner la valeur des materiaux destines a etre utilises pour la construction des piles. II s'agit de mesurer la section efficace de capture de ces materiaux en les comparant soit a un echantillon etalon du meme materiau, soit a un element de section efficace supposee connue. On etudie la perturbation du fonctionnement de la pile engendree par l'introduction periodique d'un echantillon du materiau a etudier. Cette methode est basee sur la mesure de l'angle de phase du signal fourni par la chambre d'ionisation. Ce signal resulte de la composition d'un signal local et d'un signal global dus aux effets de diffusion et de capture. Cette methode permet la comparaison de la capture de 2 echantillons de corps tres diffusants et peu capturants comme le graphite,le beryllium, l'oxyde de beryllium, avec une bonne precision. Elle permet par ailleurs de determiner la section efficace de capture de corps tels que le magnesium ou l'aluminium. (M.B.)

  5. Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1

    DEFF Research Database (Denmark)

    Gerdes, K; Helin, K; Christensen, O W

    1988-01-01

    The parB locus of plasmid R1, which mediates plasmid stability via postsegregational killing of plasmid-free cells, encodes two genes, hok and sok. The hok gene product is a potent cell-killing protein. The hok gene is regulated at the translational level by the sok gene-encoded repressor, a small...

  6. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    de confirmer l'efficacite du procede de preparation de surface et d'identifier les conditions de croissance optimales. Les resultats de caracterisation indiquent que les materiaux obtenus presentent une tres faible rugosite de surface, une bonne qualite cristalline et un dopage residuel relativement important. De plus, l'interface GaAs/Ge possede une faible densite de defauts. Finalement, la diffusion d'arsenic dans le substrat de germanium est comparable aux valeurs trouvees dans la litterature pour la croissance a basse temperature avec les autres procedes d'epitaxie courants. Ces resultats confirment que la technique d'epitaxie par faisceaux chimiques (CBE) permet de produire des couches de GaAs sur Ge de qualite adequate pour la fabrication de cellules solaires a haute performance. L'apport a la communaute scientifique a ete maximise par le biais de la redaction d'un article soumis a la revue Journal of Crystal Growth et la presentation des travaux a la conference Photovoltaics Canada 2010 . Mots-cles : Epitaxie par jets chimiques, Chemical beam epitaxy, CBE, MOMBE, Germanium, GaAs, Ge

  7. Should we routinely remove the dose delivered by the images of control?; Faut-il systematiquement retirer la dose delivree par les images de controle?

    Energy Technology Data Exchange (ETDEWEB)

    Goasduff, G. [Centre Hospitalier Universitaire Morvan, Service de Radiotherapie, 29 - Brest (France); Pene Baverez, D.; Pradier, O.; Bouchekoua, M. [Service de Radiotherapie, 29 - Brest (France)

    2009-10-15

    The constraints of doses fixed by the international commission on radiation units and measurements (ICRU) for the target volume (95-107% of the prescribed dose) are respected. for the hypo fractionated treatments, it is necessary to control the impact of the dose delivered by the control images for every patient. The dose delivered at the isocenter is estimated between 1 and 3 Gy by control image: this dose depends on the beams size and on the distance-source-skin. Protocols of the patient positioning checking must be implemented on optimizing their frequency to limit the dose received by the patient. (N.C.)

  8. Canning by the diffusion caused by a heated die; Gainage par diffusion par filiere chauffante

    Energy Technology Data Exchange (ETDEWEB)

    Gauthron, M [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    In this process, the uranium fuel is clad with a zirconium can by passing the element through a die. The operation takes place at a temperature varying between 500 and 1000 deg. C. The heating is obtained by passing low voltage electric current through the can. This process differs from the co-extrusion process in that the uranium is not deformed. The uranium is therefore machined to the final dimensions before canning, it can also be hollow. Two types of processes can be adopted for the extrusion: a) Process in which the binding of the can to the uranium is obtained without diffusion (here the can is at high temperature - subsequently cooled - and the uranium is at a low temperature); b) Process in which uranium-zirconium diffusion is initiated. No matter which process is adopted the element is subsequently heat treated in an over at 800 deg. C in order to obtain the final diffusion. The quality of this diffusion is dependent on the initial state of the surfaces and on the degree of vacuum maintained during the operation. (author) [French] Dans ce procede, la gaine zirconium est plaquee sur le combustible uranium par passage dans une filiere. L'operation a lieu a chaud, a une temperature variant entre 500 et 1000 deg. C. Le chauffage est assure par passage d'un courant basse tension dans la gaine. A la difference du procede de cofilage, l'uranium ne subit pas de deformation durant l'operation. Il est donc prealablement usine aux cotes definitives et peut etre creux. Deux processus sont possibles pendant le passage dans la filiere: a) Obtention d'un frettage de la gaine sur l'uranium sans diffusion (avec une gaine a haute temperature et un tube d'uranium a basse temperature, eventuellement refroidi); b) Obtention d'un commencement de diffusion uranium-zirconium. Quelque soit le processus adopte, la cartouche est ensuite traitee dans un four a 800 deg. C pour obtenir la diffusion definitive. La qualite de celle-ci depend essentiellement des etats de surface initiaux

  9. La pelade par plaques

    Science.gov (United States)

    Spano, Frank; Donovan, Jeff C.

    2015-01-01

    Résumé Objectif Présenter aux médecins de famille des renseignements de base pour faire comprendre l’épidémiologie, la pathogenèse, l’histologie et l’approche clinique au diagnostic de la pelade par plaques. Sources des données Une recension a été effectuée dans PubMed pour trouver des articles pertinents concernant la pathogenèse, le diagnostic et le pronostic de la pelade par plaques. Message principal La pelade par plaques est une forme de perte pileuse auto-immune dont la prévalence durant une vie est d’environ 2 %. Des antécédents personnels ou familiaux de troubles auto-immuns concomitants, comme le vitiligo ou une maladie de la thyroïde, peuvent être observés dans un petit sous-groupe de patients. Le diagnostic peut souvent être posé de manière clinique en se fondant sur la perte de cheveux non cicatricielle et circulaire caractéristique, accompagnée de cheveux en « point d’exclamation » en périphérie chez ceux dont le problème en est aux premiers stades. Le diagnostic des cas plus complexes ou des présentations inhabituelles peut être facilité par une biopsie et un examen histologique. Le pronostic varie largement et de mauvais résultats sont associés à une apparition à un âge précoce, une perte importante, la variante ophiasis, des changements aux ongles, des antécédents familiaux ou des troubles auto-immuns concomitants. Conclusion La pelade par plaques est une forme auto-immune de perte de cheveux périodiquement observée en soins primaires. Les médecins de famille sont bien placés pour identifier la pelade par plaques, déterminer la gravité de la maladie et poser le diagnostic différentiel approprié. De plus, ils sont en mesure de renseigner leurs patients à propos de l’évolution clinique de la maladie ainsi que du pronostic général selon le sous-type de patients.

  10. Development of a model of the interaction of an electromagnetic field with an ideal planar defect within a conductive medium. Application to eddy current non destructive testing; Developpement d'un modele d'interaction d'un champ electromagnetique avec un defaut plan dans un materiau conducteur. Application a la simulation d'un procede de controle non destructif par courants de Foucault

    Energy Technology Data Exchange (ETDEWEB)

    Maurice, L

    2006-12-15

    The Eddy Current (EC) Non Destructive Testing (NDT) is used in various industrial fields. The modelling of the implied phenomena brings a substantial hand for the understanding, the set-up and the optimisation of the investigations to be performed. It requires the resolution of the Maxwell equations that can be achieved with semi-analytical models, based on an integral methods. The Volume Integral Method (VIM) enables to simulate various EC NDT configurations involving volumetric defects. Nevertheless, important formalism and numerical problems appear when the considered defect has a small aperture, and computational times become very high. This is the reason why the Surface Integral Model (SIM) has been developed. The defect is taken into account as a source layer of current dipole. Based on this assumption, the existence of a scalar potential quantity can be demonstrated. A study of different numerical implementations enables to select the most efficient. Then, validations have been carried out, comparing probe responses, computed by SIM, VIM, to experimental data. The SIM model turns out to be very fast, and well adapted to get 2-D probe responses, with good accuracy. Nevertheless, the hypotheses used in the SIM formalism appeared to be very restrictive for some configurations. A model has been set up, that takes advantages of both VIM and SIM. The dipole density evaluation is still based on surface hypotheses, therefore the computational load is comparable to the ones of SIM. The computations are then improved by the evaluation of the total field, which enables to partially take into account the defect aperture. Another set of comparisons between data obtained by the three simulation models and experimental measurements has been carried out, for numerous configurations. Some of them namely imply probes made of two coils, separately transmitting and receiving.The new 'hybrid' model brings suitable corrections to the SIM model. The simulation results become very satisfactory for all tested NDT configurations, with an accuracy of the order of those brought by the VIM model as well as computation load and time comparable to those of the SIM. This hybrid model will be integrated in fine to CNA. (author)

  11. Control Methods Used in the Department of Metallurgy for Structure and Fuel Elements; Methodes de Controle Utilisees au Departement de Metallurgie pour les Elements de Structure et les Elements Combustibles; Metody kontrolya struktury toplivnykh ehlementov v departamente metallurgii; Metodos de Control Utilizados en el Departamento de Metalurgia para los Elementos Estructurales y Combustibles

    Energy Technology Data Exchange (ETDEWEB)

    Destribats, Marie-Therese; Allain, C.; Prot, A.; Thome, P. [Centre d' Etudes Nucleaires de Saclay (France)

    1965-09-15

    nombreuses methodes de controle non destructif pour les differents materiaux entrant dans leur realisation, en particulier: radiographie et gammagraphie, methodes ultrasonores et courants de Foucault. Le memoire decrit les controles effectues au cours de la fabrication des reacteurs des filieres EDF (graphite- gaz) et EL4 (eau lourde) et des elements colamines. Les auteurs insistent sur quelques points caracteristiques de ces diverses methodes, dont certaines sont bien connues. Filiere EDF: mesure des epaisseurs des parois des tubes en uranium ou uranium allie, par ultrasons; recherche des cavites de ces tubes, par gammagraphie; controle des traitements thermiques de ces tubes, par ultrasons; recherche des defauts (inclusions, criques), par ultrasons dans les billettes et ebauches des gaines en MgZr; controle de l'etancheite des cartouches, par ressuage d'helium. Filiere EL 4: mesure des epaisseurs des parois des tubes de force, et de guidage en Zircaloy, par ultrasons et courants de Foucault; examen des tubes de force en Zircaloy et tube de gaine en acier inoxydable par ultrasons; radiographie sous vide des gaines en Be; controle d'etancheite des crayons, par ressuage d'helium. Elements colamines : mesure de l'epaisseur des gaines, par courants de Foucault puises; recherche de la position de l'ame sur tubes et plaques, par radiographie, comptage gamma et courants de Foucault puises; controle de l'homogeneite.du combustible, par comptage gamma; detection des defauts dans les billettes en ZrU, par ultrasons et gammagraphie; recherche des zones decollees des plaques, par ultrasons, courants de Foucault puises et mesure de resistivite. Ces mises au point ont ete faites en vue de leur utilisation industrielle. Plusieurs de ces controles sont effectues couramment en cours de fabrication, d'autres le seront prochainement et certains sont susceptibles de l'etre a plus longue echeance. (author) [Spanish] Los estudios del Commissariat a l'Energie Atomique sobre diversos tipos de

  12. Control and diagnosis oriented modelling of the compression ignition engine; Modelisation du moteur a allumage par compression dans la perspective du controle et du diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Grondin, O

    2004-12-15

    This thesis has described an investigation into the modelling of compression ignition engine for control and diagnosis purpose. The Diesel engine is the most efficient and clean internal combustion engine due to modem electromechanical actuators. However, pollutant emission regulations are much more stricter, thus, these complex systems need sophisticated and efficient control algorithms to reach very low emission levels. For this task, engine models are required at each step of the control system development: control laws synthesis, simulation and validation. The system under study is a six cylinder direct injection Diesel engine fitted with a turbocharger. The model of this system is based on physical laws for some parts of the engine such as cylinders, manifolds, turbocharger and crank-slider system. In order to reduce computing time we choose to model heat transfer and heat release during combustion using simple empirical correlations. Resulting model has been implemented in the Matlab-Simulink environment and it can predict variables of interest for control purpose with one degree crank angle resolution. The model has been tested numerically and compared with an industrial engine simulation code with good results. Moreover, model output variables are in good agreement with experimental data recorded on a heavy-duty research engine. The engine model has been embedded on a board providing enough computing performances to perform real-time simulations, this will be helpful for 'hardware-in-the-loop' simulations. Another part of this study is dedicated to the combustion process modelling using a non linear phenomenological model: the NARMAX model. The goal is to predict the in-cylinder pressure evolution using other measurements available on the engine. The NARMAX model parameters have been identified using input-output data carried out from the experimental engine. Such model is well suited for real-time applications compare to numerically cost effective physical

  13. Control and diagnosis oriented modelling of the compression ignition engine; Modelisation du moteur a allumage par compression dans la perspective du controle et du diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Grondin, O.

    2004-12-15

    This thesis has described an investigation into the modelling of compression ignition engine for control and diagnosis purpose. The Diesel engine is the most efficient and clean internal combustion engine due to modem electromechanical actuators. However, pollutant emission regulations are much more stricter, thus, these complex systems need sophisticated and efficient control algorithms to reach very low emission levels. For this task, engine models are required at each step of the control system development: control laws synthesis, simulation and validation. The system under study is a six cylinder direct injection Diesel engine fitted with a turbocharger. The model of this system is based on physical laws for some parts of the engine such as cylinders, manifolds, turbocharger and crank-slider system. In order to reduce computing time we choose to model heat transfer and heat release during combustion using simple empirical correlations. Resulting model has been implemented in the Matlab-Simulink environment and it can predict variables of interest for control purpose with one degree crank angle resolution. The model has been tested numerically and compared with an industrial engine simulation code with good results. Moreover, model output variables are in good agreement with experimental data recorded on a heavy-duty research engine. The engine model has been embedded on a board providing enough computing performances to perform real-time simulations, this will be helpful for 'hardware-in-the-loop' simulations. Another part of this study is dedicated to the combustion process modelling using a non linear phenomenological model: the NARMAX model. The goal is to predict the in-cylinder pressure evolution using other measurements available on the engine. The NARMAX model parameters have been identified using input-output data carried out from the experimental engine. Such model is well suited for real-time applications compare to numerically cost

  14. Biological Monitoring for Plutonium-241; Detection du Plutonium-241 par Controles Biologiques; Dozimetriya Plutoniya-241 v biologicheskikh materialakh; Determinacion del Plutonio-241 en Sustancias Biologicas

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, J. C.; McDonald, B. J.; Barnes, V. [United Kingdom Atomic Energy Authority, Windscale Works, Sellafield (United Kingdom)

    1965-10-15

    ) [French] Les auteurs indiquent l'origine et les caracteristiques du {sup 241}Pu, en examinant plus particulierement les risques qu'il presente pour la sante et le probleme que pose son dosage. Ils decrivent un systeme de comptage, qui est en voie d'elaboration a Windscale, pour doser de petites quantites de {sup 241}Pu dans des echantillons preleves dans le cadre d'un programme de controle biologique. Au stade actuel de sa mise au point, cette methode est pour le moins aussi sensible que les procedes signales anterieurement et elle est plus simple, plus rapide et plus rentable. Elle est essentiellement destinee aux analyses d'urine en vue de completer les renseignements deja obtenus par analyse autoradiographique des isotopes emetteurs alpha du plutonium. Le meme porte-source est utilise pour le dosage du {sup 241}Pu, ce qui permet d'eviter certains travaux preparatoires. A l'aide d'une methode fondee sur l'echange d'anions, les isotopes du plutonium sont tout d'abord separes de l'echantillon d'urine ou de toute autre matiere biologique, dans un etat de grandepurete radiochimique. Puis on les fixe par electrolyse sur un disque en acier inoxydable. Un systeme de comptage par anticoiencidence comportant un compteur proportionnel de faible volume a circulation continue de gaz et muni d'une garde anticoiencidence a scintillation en matiere plastique permet de determiner directement le spectre beta mou du {sup 241}Pu (energie maximale 20 keV, periode 13,3 a). Les dimensions sont telles que toutes les particules beta emises par le plutonium sont absorbees a l'interieur du compteur proportionnel alors que les particules alpha perdent 50% environ de leur energie dans le scintillateur en matiere plastique. Pour les deux rayonnements, la geometrie est pratiquement 2{pi}. A son stade actuel, le materiel permet de detecter 3 pCi de {sup 241}Pu en 1 h de comptage. Cela correspond au taux d'excretion urinaire de 24 h trois mois apres l'absorption d'environ 5% de la charge corporelle

  15. A fly-wheel drive with controlled-torque clutch for a reactors cooling circuit pumps; Entrainement des pompes du circuit de refrigeration d'un reacteur par volant a embrayage sous couple controle

    Energy Technology Data Exchange (ETDEWEB)

    Riettini, A [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1964-10-15

    After a theoretical study on the slowing down of a centrifugal pump, the motion equations have been checked by means of experimental tests. In order to have important slowing down times (which is the case of the cooling pumps of a research reactor) it is necessary to add a fly-wheel. To prevent troubles when starting, a block pump-fly-wheel with clutch under controlled torque was developed. It is so possible to start the fly-wheel progressively without increasing too much power of the driving motor. (author) [French] Apres une etude theorique sur le mouvement de ralentissement d'une pompe centrifuge, les equations du mouvement ont ete verifiees par des essais pratiques. Pour obtenir des temps de ralentissement importants (cas des pompes de refrigeration d'un reacteur de recherche) il est necessaire d'y adjoindre un volant d'inertie. Pour eviter les inconvenients au demarrage, on a etudie un ensemble pompe-volant avec embrayage sous couple controle. Cette solution permet de lancer progressivement le volant sans augmentation appreciable de la puissance du moteur d'entrainement. (auteur)

  16. suPAR

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Giamarellos-Bourboulis, Evangelos J

    2015-01-01

    Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most...... promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents...

  17. Current regulator for the stabilization of an electrostatic Van de Graaff generator; Regulateur de courant pour stabilisation d'un generateur electrostatique Van de Graaff

    Energy Technology Data Exchange (ETDEWEB)

    Gabet, A; Taieb, J [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

    1953-07-01

    In a previous report (CEA report number 46) we described a current regulator destined to enslave the current of charge of the strap of a model of Van de Graaff. We will now describe the regulator destined to the 5 MeV Van de Graaff built in the Nuclear center of Saclay. (author) [French] Dans un precedent rapport (rapport C.E.A. numero 46) nous avons decrit un regulateur de courant destine a asservir le courant de charge de la courroie d'une maquette de Van de Graaff. Nous decrirons maintenant le regulateur destine au Van de Graaff de 5 MeV construit au Centre d'Etudes Nucleaires de Saclay. (auteur)

  18. Pacientes com doença de Parkinson sob assistência fisioterapêutica apresentam parâmetros pulmonares melhores do que controles sedentários

    OpenAIRE

    Thomé, Jéssica dos Santos; Olmedo, Larissa; Santos, Fabiana Maria dos; Magnani, Karla Luciana; Müller, Paulo de Tarso; Christofoletti, Gustavo

    2016-01-01

    RESUMO Este estudo teve como objetivo investigar os parâmetros pulmonares (espirometria e oscilometria de impulso) de pacientes com doença de Parkinson (DP) e controles eutróficos, comparando os valores dos sujeitos participantes e os não participantes de um programa de assistência fisioterapêutica. Trinta e sete sujeitos foram divididos em quatro grupos independentes: dois grupos formados por pacientes com DP (praticantes e não praticantes de um protocolo de exercícios fisioterapêuticos real...

  19. Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls

    DEFF Research Database (Denmark)

    Langkilde, Anne; Petersen, Janne; Henriksen, Jens Henrik

    2015-01-01

    BACKGROUND: HIV-infected patients could exhibit accelerated ageing, since age-associated complications like sarcopenia; increased inflammation; lipodystrophy with loss of subcutaneous adipose tissue and/or gain of visceral adipose tissue (VAT); and cardiovascular disease occur at an earlier age...... was significantly positively associated with fat mass index (FMI) and abdominal VAT, but not with lean mass index (LMI). IL-6 was significantly associated with both FMI and VAT, and low LMI. High suPAR was associated with low LMI, and weakly with high FMI and VAT. CONCLUSIONS: Leptin reflected adiposity...

  20. Dresses problems arising from hot-plant operation and their solution (1961); Les problemes vestimentaires poses par l'exploitation des installations actives et leurs solutions (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Bouzigues, H; Boutot, P [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1961-07-01

    acceleree en periode d'incidents doivent etre traites comme le linge des centres hospitaliers. Le lavage du linge par le procede allemand du contre-courant (systeme Sulzman) se revele un procede precieux par les cadences rapides qu'il permet et, surtout, par sa faible production d'effluents liquides. Le nettoyage a sec est une technique d'avenir qui s'avere encore plus economique. Dans une laverie active, le controle des vetements traites du point de vue de la contamination residuaire peut constituer un serieux goulet d'etranglement a la production du linge propre s'il n'est pas solutionne par l'utilisation de machines automatiques a cadence rapide. Le risque encouru par le personnel d'exploitation est uniquement la contamination de l'atmosphere et des surfaces. A ce titre, l'installation doit etre traitee comme une zone active dans laquelle sont manipules journellement quelques dizaines de millicuries d'emetteurs dangereux et quelques microcuries de plutonium. (auteurs)

  1. Dresses problems arising from hot-plant operation and their solution (1961); Les problemes vestimentaires poses par l'exploitation des installations actives et leurs solutions (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J.; Bouzigues, H.; Boutot, P. [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1961-07-01

    renouveles a cadence acceleree en periode d'incidents doivent etre traites comme le linge des centres hospitaliers. Le lavage du linge par le procede allemand du contre-courant (systeme Sulzman) se revele un procede precieux par les cadences rapides qu'il permet et, surtout, par sa faible production d'effluents liquides. Le nettoyage a sec est une technique d'avenir qui s'avere encore plus economique. Dans une laverie active, le controle des vetements traites du point de vue de la contamination residuaire peut constituer un serieux goulet d'etranglement a la production du linge propre s'il n'est pas solutionne par l'utilisation de machines automatiques a cadence rapide. Le risque encouru par le personnel d'exploitation est uniquement la contamination de l'atmosphere et des surfaces. A ce titre, l'installation doit etre traitee comme une zone active dans laquelle sont manipules journellement quelques dizaines de millicuries d'emetteurs dangereux et quelques microcuries de plutonium. (auteurs)

  2. Parálisis cerebral :

    OpenAIRE

    Cabrero Izquierdo, María del Carmen

    2012-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  3. Á contre-courant : les mobilités caribéennes vers l’Éthiopie

    Directory of Open Access Journals (Sweden)

    Giulia Bonacci

    2008-09-01

    Full Text Available L’article s’intéresse à la migration des Caribéens vers l’Ethiopie, et notamment celle des Rastafariens qui se définissent comme de « vrais Éthiopiens » et se disent « rapatriés » en Éthiopie. En dépit de leur nombre limité, ils n’en sont pas moins importants car ils illustrent la persistance et les transformations des imaginaires et idéologies liant les Noirs du monde à l’Éthiopie ainsi qu’un pan méconnu des mobilités caribéennes qui, se dirigeant vers l’Afrique, se découvrent complètement à contre-courant.The article deals with Caribbean migration towards Ethiopia, and especially the one of Rastafarians who define themselves as ‘true Ethiopians’ and ‘repatriates’ in Ethiopia. Despite their limited number, their experience is nonetheless important as it reveals the persistence and change in imaginaries and ideologies linking black all over the world to Ethiopia as well as unknown Caribbean mobility towards Africa, a mobility which is driven against the current.

  4. Câbles électriques - Calcul du courant admissible - Partie 2: Résistance thermique - Section 2: Méthode de calcul des coefficients de réduction de l'intensité de courant admissible pour des groupes de câbles posés à l'air libre et protégés du rayonnement solaire direct

    CERN Document Server

    1995-01-01

    Câbles électriques - Calcul du courant admissible - Partie 2: Résistance thermique - Section 2: Méthode de calcul des coefficients de réduction de l'intensité de courant admissible pour des groupes de câbles posés à l'air libre et protégés du rayonnement solaire direct

  5. Correlation between symptoms and sagittal alignment parameters in patients with lumbar canal stenosis: a case-control study Correlación entre síntomas y parámetros de alineación sagital en pacientes con estenosis del canal lumbar: un estudio de control de casos Correlação entre os sintomas e os parâmetros de alinhamento sagital em pacientes com estenose do canal lombar: estudo de caso-controle

    Directory of Open Access Journals (Sweden)

    Paulo Tadeu Maia Cavali

    2012-12-01

    Full Text Available OBJECTIVE: To examine the relationship between sagittal balance parameters and different symptoms of spinal disease in patients with lumbar canal stenosis (LCS and controls. METHODS: In this prospective, diagnostic, case-control study, we included all patients consecutively admitted to a public teaching hospital for surgical treatment of LCS between July 2010 and October 2011, aged more than 40 years, with back pain plus radiculopathy or neurogenic claudication, and controls without LCS. Magnetic resonance and x-rays allowed the measurement of sagittal axis parameters. Clinical data, the Oswestry Disability Index and the visual analogue scale of pain were assessed. RESULTS: 23 patients were in the Stenosis group, and 17 were controls. The Stenosis group presented lower values of total lumbopelvic lordosis and regional lordosis L1, L2 and L3. In LCS patients and back pain, total lumbopelvic and regional lordosis at L1, L2 and L3 were smaller. Those with stenosis and radiculopathy had higher values of pelvic tilt and lower total lumbopelvic lordosis and regional lordosis in L1 and L2. In patients with claudication, regional lumbopelvic lordosis in L1 and L2 and the T9 sagittal offset were smaller. All patients with pain had higher values of thoracic kyphosis, regional lumbopelvic lordosis in L1, lower values for pelvic tilt, sagittal T1 offset, sacro-femoral distance and overhang compared to patients without pain. CONCLUSIONS: This study shows significant correlations between symptoms and sagittal axis parameters between patients with and without spinal canal stenosis and also in subgroups of the patients with stenosis with different complaints.OBJETIVO: Analizar la relación entre los parámetros del equilibrio sagital y los diversos síntomas de enfermedad espinal en pacientes con estenosis del canal lumbar (ECL y sus controles. MÉTODOS: En esta perspectiva, de estudio de diagnóstico, de control de casos, incluimos a todos los pacientes

  6. Theory and Practice of a New Class of Equipment for Separation of Particulates from Gases: the Turbulent Flow Precipitator Le précipitateur turbulent : un nouveau type de dispositif de séparation de particules présentes dans un courant de gaz. Théorie et technologie

    Directory of Open Access Journals (Sweden)

    Dullien F. A. L.

    2006-12-01

    Full Text Available The main classes of separators of particulates from gases comprise inertial separators, filters, (wet scrubbers and electrostatic precipitators, each of which technique has its proper niche and each has its advantages and its disadvantages. In the present paper a new class of equipment, the turbulent flow precipitator (TFP for gas cleaning is described that, though at the present only in its infancy, is rapidly gaining popularity because it has some advantages over each and every known type of separator and it has very few limitations. TFPs are far more efficient for the removal of fine particles than inertial separators, unlike filters they do not plug up, they do not present secondary disposal problems and they require less maintenance (and are less expensive than electrostatic precipitators. They can be very efficient also in the submicron range of particle size and there are no practical limitations as far as high temperatures and/or corrosive atmospheres are concerned. They are equally suitable for the removal of solid and liquid particles from gases. Turbulent flow precipitators work on the principle of turbulent eddy penetration into deep regions where there is no net flow, where the eddies die out and where the fine particulates carried by the eddies deposit on collector surfaces. TFPs comprise two well defined regions:- straight, uniform and unobstructed flow passages in which the gas carrying the suspended fine particulates is passed in turbulent flow;- and adjacent collection regions where there is no net gas flow and where all of the separation of particles from the gas takes place. Hence, a TFP is a filter in which the separation of the particulates from the gas takes place outside the passages where the gas flows. Les principaux séparateurs de particules dans un courant de gaz existants sur le marché sont les séparateurs par inertie, les filtres, les laveurs et les électrofiltres. Chaque type de séparateur est destiné à une

  7. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  8. Efeito da postura no controle da força de preensão do membro superior não parético ao acidente vascular encefálico

    OpenAIRE

    Silva, Fábio Santi Rosendo da

    2011-01-01

    Este trabalho teve como objetivo analisar a influência da condição postural sentado e em pé na adaptação do controle da força de preensão manual do membro superior não parético durante a atividade de pegar e levantar um objeto, em indivíduos com hemiparesia após acidente vascular encefálico (AVE). Foram avaliados 15 indivíduos com hemiparesia (GE) e 15 indivíduos saudáveis (GC) com idade de 57,3 ±10,17 e 55,5±11,27 anos respectivamente. Para caracterização do GE foram realizados os testes de ...

  9. Par Pond vegetation status 1996

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-12-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  10. Operation of a direct current transformer used as a 'flux pump'; Fonctionnement du transformateur a courant continu utilise en 'pompe a flux'

    Energy Technology Data Exchange (ETDEWEB)

    Deschanels, J L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The author derives the equations governing the operation of a flux pump with a superconducting transformer. He shows that these exists a limiting value of the current in the charge coil and that the limit is independent of this coil. (author) [French] L'auteur etablit les equations de fonctionnement d'une pompe a flux a transformateur supraconducteur, il montre l'existence d'une limite, du courant dans la self de charge et l'independance de cette limite vis-a-vis de cette self. (auteur)

  11. Les accidents de la vie courante chez l’enfant à Dakar: à propos de 201 cas

    Science.gov (United States)

    Mohamed, Azhar Salim; Sagna, Aloïse; Fall, Mbaye; Ndoye, Ndeye Aby; Mbaye, Papa Alassane; Fall, Aimé Lakh; Diaby, Alou; Ndour, Oumar; Ngom, Gabriel

    2017-01-01

    Les accidents de la vie courante (AcVC) sont fréquents chez l’enfant et peuvent être à l’origine de lésions handicapantes et de décès. L’objectif de notre travail était d’étudier les aspects épidémiologiques et lésionnels des AcVC à Dakar. C’est une étude transversale descriptive menée du 1er Janvier 2013 au 30 juin 2013. Les enfants victimes d’accidents domestiques, d’accidents de sport et de loisirs ou d’accidents scolaires ont été inclus. Nous avons étudié des paramètres généraux et des paramètres ayant trait à chaque type d’AcVC. Deux cent et un enfants ont été inclus, ce qui représentait 27% des consultations aux urgences. Il y avait 148 garçons et 53 filles. Les enfants de moins de 5 ans étaient les plus touchés (37,8%). Le football et le jeu de lutte étaient les grands pourvoyeurs d’AcVC. Les AcVC survenaient principalement à domicile (58,2%) et dans les aires de sport et de loisirs (31,8%). Les fractures prédominaient dans les différents types d’AcVC: 54,9% des accidents domestiques, 68,8% des accidents de sport et de loisirs et 40% des accidents scolaires. Au plan épidémiologique, nos résultats sont superposables à la littérature. Les fractures prédominent à l’opposé de la littérature où les contusions sont prépondérantes. Le jeu de lutte est le plus grand pourvoyeur de ces fractures après le football. La connaissance des aspects épidémiologiques et lésionnels permet de mener des campagnes de prévention des AcVC à Dakar. PMID:29187941

  12. Study protocol of EMPOWER participatory action research (EMPOWER-PAR): a pragmatic cluster randomised controlled trial of multifaceted chronic disease management strategies to improve diabetes and hypertension outcomes in primary care.

    Science.gov (United States)

    Ramli, Anis S; Lakshmanan, Sharmila; Haniff, Jamaiyah; Selvarajah, Sharmini; Tong, Seng F; Bujang, Mohamad-Adam; Abdul-Razak, Suraya; Shafie, Asrul A; Lee, Verna K M; Abdul-Rahman, Thuhairah H; Daud, Maryam H; Ng, Kien K; Ariffin, Farnaza; Abdul-Hamid, Hasidah; Mazapuspavina, Md-Yasin; Mat-Nasir, Nafiza; Miskan, Maizatullifah; Stanley-Ponniah, Jaya P; Ismail, Mastura; Chan, Chun W; Abdul-Rahman, Yong R; Chew, Boon-How; Low, Wilson H H

    2014-09-13

    Chronic disease management presents enormous challenges to the primary care workforce because of the rising epidemic of cardiovascular risk factors. The chronic care model was proven effective in improving chronic disease outcomes in developed countries, but there is little evidence of its effectiveness in developing countries. The aim of this study was to evaluate the effectiveness of the EMPOWER-PAR intervention (multifaceted chronic disease management strategies based on the chronic care model) in improving outcomes for type 2 diabetes mellitus and hypertension using readily available resources in the Malaysian public primary care setting. This paper presents the study protocol. A pragmatic cluster randomised controlled trial using participatory action research is underway in 10 public primary care clinics in Selangor and Kuala Lumpur, Malaysia. Five clinics were randomly selected to provide the EMPOWER-PAR intervention for 1 year and another five clinics continued with usual care. Each clinic consecutively recruits type 2 diabetes mellitus and hypertension patients fulfilling the inclusion and exclusion criteria over a 2-week period. The EMPOWER-PAR intervention consists of creating/strengthening a multidisciplinary chronic disease management team, training the team to use the Global Cardiovascular Risks Self-Management Booklet to support patient care and reinforcing the use of relevant clinical practice guidelines for management and prescribing. For type 2 diabetes mellitus, the primary outcome is the change in the proportion of patients achieving HbA1c diabetes mellitus, the primary outcome is the change in the proportion of patients achieving blood pressure care and prescribing patterns. Patients' assessment of their chronic disease care and providers' perceptions, attitudes and perceived barriers in care delivery and cost-effectiveness of the intervention are also evaluated. Results from this study will provide objective evidence of the effectiveness and

  13. Design and construction of a faraday cup for measuring small electron currents; Etudes et realisation d'une ''coupe de faraday'' pour les mesures de faibles courants electroniques

    Energy Technology Data Exchange (ETDEWEB)

    Veyssiere, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    This paper describes the design of a device for measuring and integrating very small currents generated by the impact of a charged particle beam upon a Faraday cup. Part one considers the detector as such. The main component is a graphite bloc capable of stopping practically all the incident charges. Part two describes the associated electrode apparatus required to measure better than 10{sup -13} ampere with a precision- of 1 per cent: Integration of such weak currents over periods of several hours, in the presence of a strong background current, is also discussed. (author) [French] Ce rapport decrit l'etude et la realisation d'un ensemble permettant de mesurer et d'integrer sur des periodes de plusieurs heures des courants electroniques tres faibles provenant d'un faisceau de particules chargees, Dans la premiere partie du rapport nous etudierons le capteur proprement dit qui se compose essentiellement d'un bloc de graphite dont la forme et les dimensions sont telles, que la majeure partie des charges (positons et negatons de 60 MeV) est captee (1 pour mille reussissent a s'echapper). Dans la deuxieme partie nous decrivons l'appareillage associe au capteur capable de mesurer moins de 10{sup -13} ampere avec une precision de l'ordre du pour cent et d'integrer ce courant sur des periodes de temps variables, compte tenu de l'ambiance 'bruyante' (Accelerateur Lineaire) dans laquelle la mesure s'effectue. (auteur)

  14. Automatic optimisation of beam orientations using the simplex algorithm and optimisation of quality control using statistical process control (S.P.C.) for intensity modulated radiation therapy (I.M.R.T.); Optimisation automatique des incidences des faisceaux par l'algorithme du simplexe et optimisation des controles qualite par la Maitrise Statistique des Processus (MSP) en Radiotherapie Conformationnelle par Modulation d'Intensite (RCMI)

    Energy Technology Data Exchange (ETDEWEB)

    Gerard, K

    2008-11-15

    Intensity Modulated Radiation Therapy (I.M.R.T.) is currently considered as a technique of choice to increase the local control of the tumour while reducing the dose to surrounding organs at risk. However, its routine clinical implementation is partially held back by the excessive amount of work required to prepare the patient treatment. In order to increase the efficiency of the treatment preparation, two axes of work have been defined. The first axis concerned the automatic optimisation of beam orientations. We integrated the simplex algorithm in the treatment planning system. Starting from the dosimetric objectives set by the user, it can automatically determine the optimal beam orientations that best cover the target volume while sparing organs at risk. In addition to time sparing, the simplex results of three patients with a cancer of the oropharynx, showed that the quality of the plan is also increased compared to a manual beam selection. Indeed, for an equivalent or even a better target coverage, it reduces the dose received by the organs at risk. The second axis of work concerned the optimisation of pre-treatment quality control. We used an industrial method: Statistical Process Control (S.P.C.) to retrospectively analyse the absolute dose quality control results performed using an ionisation chamber at Centre Alexis Vautrin (C.A.V.). This study showed that S.P.C. is an efficient method to reinforce treatment security using control charts. It also showed that our dose delivery process was stable and statistically capable for prostate treatments, which implies that a reduction of the number of controls can be considered for this type of treatment at the C.A.V.. (author)

  15. Vote par sondage uniforme incorruptible

    OpenAIRE

    Blanchard , Nicolas

    2016-01-01

    International audience; Introduit en 2012 par David Chaum, le vote par sondage uniforme (random-sample voting) est un protocole de vote basé sur un choix d'une sous-population représentative , permettant de limiter les coûts tout en ayant de nombreux avantages, principalement lorsqu'il est couplé a d'autres techniques comme ThreeBallot. Nous analysons un problème de corruptibilité potentielle où les votants peuvent vendre leur vote au plus offrant et proposons une variation du protocole reméd...

  16. Grandeurs caractéristiques de la machine synchrone obtenues analytiquement à partir d'une réduction de modèle par une technique des multiéchelles de temps

    OpenAIRE

    Guesbaoui , H.

    1995-01-01

    Il est bien connu qu'il n'est pas possible d'avoir une écriture simple des courants et des tensions pour une machine synchrone modélisée par plus d'un amortisseur par axe d et q de Park. De plus, seules des méthodes numériques permettent un calcul approché de ses grandeurs caractéristiques. Dans cet article nous proposons de déterminer les constantes de temps sous une forme analytique à partir de l'écriture de sous-systèmes réduits du premier ordre décrivant les régimes subtransitoire, transi...

  17. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity

    Directory of Open Access Journals (Sweden)

    Henrique FUKUSHIMA

    Full Text Available Abstract Recent studies investigating protease-activated receptor type 2 (PAR-2 suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF of patients with moderate chronic periodontitis (MP. The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19 at baseline, and from MP patients (n = 19 and severe chronic periodontitis (SP (n = 19 patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR. PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p <0.05 PAR-2 expression in patients with periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  18. Statistical process control applied to intensity modulated radiotherapy pretreatment controls with portal dosimetry;Maitrise statistique des processus appliquee aux controles avant traitement par dosimetrie portale en radiotherapie conformationnelle avec modulation d'intensite

    Energy Technology Data Exchange (ETDEWEB)

    Villani, N.; Noel, A. [Laboratoire de recherche en radiophysique, CRAN UMR 7039, Nancy universite-CNRS, 54 - Vandoeuvre-les-Nancy (France); Villani, N.; Gerard, K.; Marchesi, V.; Huger, S.; Noel, A. [Departement de radiophysique, centre Alexis-Vautrin, 54 - Vandoeuvre-les-Nancy (France); Francois, P. [Institut Curie, 75 - Paris (France)

    2010-06-15

    Purpose The first purpose of this study was to illustrate the contribution of statistical process control for a better security in intensity modulated radiotherapy (I.M.R.T.) treatments. This improvement is possible by controlling the dose delivery process, characterized by pretreatment quality control results. So, it is necessary to put under control portal dosimetry measurements (currently, the ionisation chamber measurements were already monitored by statistical process control thanks to statistical process control tools). The second objective was to state whether it is possible to substitute ionisation chamber with portal dosimetry in order to optimize time devoted to pretreatment quality control. Patients and methods At Alexis-Vautrin center, pretreatment quality controls in I.M.R.T. for prostate and head and neck treatments were performed for each beam of each patient. These controls were made with an ionisation chamber, which is the reference detector for the absolute dose measurement, and with portal dosimetry for the verification of dose distribution. Statistical process control is a statistical analysis method, coming from industry, used to control and improve the studied process quality. It uses graphic tools as control maps to follow-up process, warning the operator in case of failure, and quantitative tools to evaluate the process toward its ability to respect guidelines: this is the capability study. The study was performed on 450 head and neck beams and on 100 prostate beams. Results Control charts, showing drifts, both slow and weak, and also both strong and fast, of mean and standard deviation have been established and have shown special cause introduced (manual shift of the leaf gap of the multi-leaf collimator). Correlation between dose measured at one point, given with the E.P.I.D. and the ionisation chamber has been evaluated at more than 97% and disagreement cases between the two measurements were identified. Conclusion The study allowed to

  19. Parâmetros genéticos para produção de leite no dia do controle de vacas da raça Holandesa utilizando modelos de análises de fatores e componentes principais

    Directory of Open Access Journals (Sweden)

    Mariana de Almeida Dornelles

    2015-06-01

    Full Text Available Objetivou-se comparar um modelo multi-característica padrão com modelos de análise de fatores (AF e de componentes principais (CP para estimar parâmetros genéticos para a produção de leite no dia do controle (PLDC de vacas da raça Holandesa. O arquivo de trabalho constituiu-se de 4.616 registros mensais de PLDC de primeiras lactações de vacas da raça Holandesa. As PLDC foram agrupadas em dez classes mensais, entre o 5o e 305o dia da lactação (PLDC1 a PLDC10. Foram realizadas análises considerando 11 modelos diferentes, como segue: multi-característica padrão (MC; cinco modelos de posto reduzido, para a matriz de covariância genética, ajustando um a cinco (CP1 ... CP5 componentes principais; e dois modelos utilizando análise de fatores (F1, F2, F3, F4 e F5. Para todos os modelos, foram considerados como aleatórios os efeitos genético aditivo e o residual e como fixos os de grupo de contemporâneos, da idade da vaca ao parto (linear e quadrático e dias em lactação (linear. Os valores de Log L, AIC e BIC melhoraram com o aumento do número de parâmetros até CP4 e AF4. Comparando CP4 e AF4, observa-se que CP4 resultou em melhores valores de Log L, AIC e BIC. As estimativas de herdabilidade e correlações genéticas utilizando os modelos MC, CP4 e AF4 foram similares, variando de 0,06 (PL6 a 0,65 (PL10 e de 0,05 (PL4xPL10 a 0,94 (PL2xPL3, respectivamente, indicando que a estrutura de covariâncias genéticas entre as produções de leite no dia do controle pode ser ajustada utilizando um modelo de posto reduzido, contendo quatro componentes principais ou quatro fatores

  20. Control óptimo de par para máquinas SynRM aplicadas a vehículo eléctrico

    OpenAIRE

    Trancho, Elena; Ibarra Basabe, Edorta; Arias Pujol, Antoni; Kortabarria, Iñigo

    2017-01-01

    Las máquinas de reluctancia síncrona asistidas por imanes están atrayendo un considerable interés como alternativa a las máquinas síncronas de imanes permanentes para su uso en sistemas de propulsión de vehículos eléctricos. El control óptimo de estas máquinas (incluyendo operación en debilitamiento de campo) puede resultar complejo, ya que estas son, por lo general, muy sensibles al fenómeno de la saturación magnética. En este artículo se trata su control, desde los reguladores hasta el prec...

  1. PAR-1 contributes to the innate immune response during viral infection

    Science.gov (United States)

    Antoniak, Silvio; Owens, A. Phillip; Baunacke, Martin; Williams, Julie C.; Lee, Rebecca D.; Weithäuser, Alice; Sheridan, Patricia A.; Malz, Ronny; Luyendyk, James P.; Esserman, Denise A.; Trejo, JoAnn; Kirchhofer, Daniel; Blaxall, Burns C.; Pawlinski, Rafal; Beck, Melinda A.; Rauch, Ursula; Mackman, Nigel

    2013-01-01

    Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3–induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1–/– mice expressed reduced levels of IFN-β and CXCL10 during the early phase of infection compared with Par1+/+ mice that resulted in higher viral loads and cardiac injury at day 8 after infection. Inhibition of either tissue factor or thrombin in WT mice also significantly increased CVB3 levels in the heart and cardiac injury compared with controls. BM transplantation experiments demonstrated that PAR-1 in nonhematopoietic cells protected mice from CVB3 infection. Transgenic mice overexpressing PAR-1 in cardiomyocytes had reduced CVB3-induced myocarditis. We found that cooperative signaling between PAR-1 and TLR3 in mouse cardiac fibroblasts enhanced activation of p38 and induction of IFN-β and CXCL10 expression. Par1–/– mice also had decreased CXCL10 expression and increased viral levels in the lung after influenza A infection compared with Par1+/+ mice. Our results indicate that the tissue factor/thrombin/PAR-1 pathway enhances IFN-β expression and contributes to the innate immune response during single-stranded RNA viral infection. PMID:23391721

  2. Developpement d'un estimateur d'etat energetique d'un chauffe-eau pour un controle par champ moyen

    Science.gov (United States)

    Solis, Jerome

    Domestic electric water heaters (EWH) provide an interesting energy storage potential that can be exploited in the context of smart grids. For example, a variation of 1 °C of the water temperature of an EWH of 270 liters corresponds to 0.313 kWh of energy. For utilities like Hydro-Quebec, which has about 2 million EWH connected to its grid, this represents a strong storage potential. This storage source already present on the network could allow, using an adequate control strategy, to smooth the electricity consumption curve by moving some of the load occurring during peak periods to trough periods. This thesis position itself in the context of developing a simulation platform to implement a mean field control strategy of water heaters on the grid. This innovative approach enables control of all water heaters to meet a global objective while respecting local constraints of each. To be functional, the strategy requires several components to be integrated into the simulation platform. Specifically, this thesis focuses on the development of a numerical model and the estimation of the state in temperature and energy of an EWH. The proposed model for predicting the behavior of a EWH is a multi-nodal model. This approach allows discretizing the tank of an EWH into smaller volumes. The energy conservation equation is solved for each of these sub-volumes and it is possible to predict changes in the output mean temperature with an average error of 2.4 °C. The results from the multi-nodal model compare favorably with numerical reference models, found in the TRNSYS thermal simulation software, as well as experimental measurements of temperature of an electric water heater. In this model, the temperature is assumed to be uniform for each sub-volume and the standby losses are considered constants. Although the model is linear, a correction routine allows redistributing adequately heat within the tank while respecting the thermal dynamics of the heater, including the presence

  3. Etude théorique et expérimentale d'un processus thermique dans un limiteur supraconducteur de courant

    Science.gov (United States)

    Lévêque, J.; Netter, D.; Rezzoug, A.; Caron, J. P.

    1995-12-01

    The increasing of fault current level in electrical networks leads to a new interest for superconducting current limiters since 1983 when an ac wire with low losses has been developed. They are based on the natural transition from the superconducting state to the normal resistive state. In order to study the transition usual models are not sufficient. This paper deals with a numerical resolution of the electro-thermical coupled problem. Computed and experimental results are favorably compared. Some factors which affect the transition as well as the influence of the starting instant are studied. L'accroissement des courants de court-circuit dans les réseaux électriques a ravivé l'intérêt pour les limiteurs supraconducteurs de courant depuis la mise au point en 1983 de fil supraconducteur à faibles pertes en régime variable. Le principe de fonctionnement de ces limiteurs est fondé sur la transition vers l'état normal du matériau supraconducteur. Les modèles simplifiés s'avèrent insuffisants pour l'étude de la transition, une méthode de résolution numérique du problème électrothermique est donc faite. Les résultats des simulations sont comparés à ceux d'expérimentation puis deux études, l'une de facteurs influant sur la propagation de la transition, l'autre du type de court-circuit, sont menées.

  4. Legal and Administrative Problems of Controlling the Disposal of Nuclear Wastes in the Sea; Problemes Juridiques et Administratifs Poses par le Controle de l'Elimination des Dechets Nucleaires dans la Mer; 041f 0420 041e 0414 ; Problemas Juridicos y Administrativos que Plantea el Control de la Evacuacion de Desechos Nucleares En El Mar

    Energy Technology Data Exchange (ETDEWEB)

    Hydeman, Lee M.; Berman, William H. [Atomic Energy Research Project, University of Michigan Law School (United States)

    1960-07-01

    The basic purpose of the paper is to present some approaches to multinational control of the sea disposal of nuclear wastes, considering both the type of international .control which may be appropriate and the means for accomplishing such control. First, the authors give a brief description of the kind of control which appears to be necessary in protecting public health against the hazards of the disposal of wastes in the sea. The second part consists of a general analysis of the legal problems posed by nuclear wastes. Emphasis is placed on the authority of coastal states to impose unilateral control on the disposal of wastes by other nations if such disposal might adversely affect their interests. The authors inquire into the adequacy of legal remedies as well as the possible rule of law regarding the prevention of damage from waste disposal and the apportionment of liability in the event that such damage does occur. The third part is an analysis of how other problems of control have been handled, both unilaterally and multilaterally. The final part consists of an inquiry into various means of internationally controlling the sea disposal of nuclear wastes. The role of existing international bodies in the maintenance of continuing administrative control at the international level is mentioned. (author) [French] Le but essentiel du memoire est d'exposer diverses facons d'envisager le probleme du controle multinational de l'evacuation des dechets nucleaires dans l'eau de mer, en examinant a la fois le type de controle international approprie et les moyens de le mettre en oeuvre. La premiere partie contiendra une description succincte du genre de controle qui semble necessaire pour la protection de la sante publique contre les effets de l'evacuation des dechets dans la mer. La deuxieme partie consistera en une analyse generale des problemes juridiques poses par. l'elimination des dechets nucleaires. Les auteurs traiteront particulierement du droit des Etats riverains

  5. Study of the dry processing of uranium ores; Etude des traitements de minerais d'uranium par voie seche

    Energy Technology Data Exchange (ETDEWEB)

    Guillet, H

    1959-02-01

    A description is given of direct fluorination of pre-concentrated uranium ores in order to obtain the hexafluoride. After normal sulfuric acid treatment of the ore to eliminate silica, the uranium is precipitated by a load of lime to obtain: either impure calcium uranate of medium grade, or containing around 10% of uranium. This concentrate is dried in an inert atmosphere and then treated with a current of elementary fluorine. The uranium hexafluoride formed is condensed at the outlet of the reaction vessel and may be used either for reduction to tetrafluoride and the subsequent manufacture of uranium metal or as the initial product in a diffusion plant. (author) [French] Il s'agit d'une description de fluoration directe de preconcentres de minerais d'uranium en vue d'obtention d'hexafluorure. Apres attaque sulfurique normale du minerai, afin d' eliminer la silice, l' uranium est precipite par un toit de chaux pour obtenir: ou uranate de chaux impur de titre moyen, ou uranium de la dizaine du pourcentage. Ce concentre seche en atmosphere inerte est soumis a un courant de fluor elementaire. L'hexafluorure d'uranium forme est condense a la sortie du reacteur et peut etre utilise soit apres reduction en tetrafluorure par l'elaboration d'uranium metal, soit comme produit de base dans le cadre d'une usine de diffusion. (auteur)

  6. Study of the dry processing of uranium ores; Etude des traitements de minerais d'uranium par voie seche

    Energy Technology Data Exchange (ETDEWEB)

    Guillet, H

    1959-02-01

    A description is given of direct fluorination of pre-concentrated uranium ores in order to obtain the hexafluoride. After normal sulfuric acid treatment of the ore to eliminate silica, the uranium is precipitated by a load of lime to obtain: either impure calcium uranate of medium grade, or containing around 10% of uranium. This concentrate is dried in an inert atmosphere and then treated with a current of elementary fluorine. The uranium hexafluoride formed is condensed at the outlet of the reaction vessel and may be used either for reduction to tetrafluoride and the subsequent manufacture of uranium metal or as the initial product in a diffusion plant. (author) [French] Il s'agit d'une description de fluoration directe de preconcentres de minerais d'uranium en vue d'obtention d'hexafluorure. Apres attaque sulfurique normale du minerai, afin d' eliminer la silice, l' uranium est precipite par un toit de chaux pour obtenir: ou uranate de chaux impur de titre moyen, ou uranium de la dizaine du pourcentage. Ce concentre seche en atmosphere inerte est soumis a un courant de fluor elementaire. L'hexafluorure d'uranium forme est condense a la sortie du reacteur et peut etre utilise soit apres reduction en tetrafluorure par l'elaboration d'uranium metal, soit comme produit de base dans le cadre d'une usine de diffusion. (auteur)

  7. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  8. Par Pond Fish, Water, and Sediment Chemistry

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  9. Indirect Determination of Half-Lives of Short-Lived Fission Gases Using a Gas Flow Method; Determination Indirecte des Courtes PeRiodes de Produits de Fission Gazeux, par une Methode a Courant Gazeux; 041a 041e 0421 0412 0415 041d 041d 041e 0415 041e 041f 0420 0415 0414 0415 041b 0415 041d 0418 0415 041f 0415 0420 0418 041e 0414 041e 0412 041f 041e 041b 0423 0420 0410 0421 041f 0410 0414 0410 041a 041e 0420 041e 0422 041a 041e 0416 0418 0412 0423 0429 0418 0425 0413 0410 0417 041e - 041e 0411 0420 0410 0417 041d 042b 0425 041f 0420 041e 0414 0423 041a 0422 041e 0412 0414 0415 041b 0415 041d 0418 042f 0421 0418 0421 041f 041e 041b 042c 0417 041e 0412 0410 041d 0418 0415 041c 041c 0415 0422 041e 0414 041e 0412 0413 0410 0417 041e 0412 041e 0413 041e 041f 041e 0422 041e 041a 0410 ; Determinacion Indirecta del T 1/2 de los Cases de Fision de Periodo Corto por un Metodo de Circulacion

    Energy Technology Data Exchange (ETDEWEB)

    Patzelt, P.; Herrmann, G. [Institut fuer Anorganische Chemie und Kernchemie der Universitaet Mainz, Mainz, Federal Republic of Germany (Germany)

    1965-07-15

    ) [French] Etant donne que l'etude de la repartition des charges dans la fission nucleaire exige que l'un determine les rendements primaires en produits de fission qui, dans la plupart des cas, sont eux-memes des produits a courte periode ou proviennent de precurseurs a courte periode, il faut proceder a des separations tres rapides et efficaces de membres voisins d'une serie radioactive. Si l'on utilise le pouvoir d'emanation extremement eleve de certains composes de l'uranium, on separe le plus facilement les produits de fission gazeux dans plus d'une douzaine de series radioactives. Cependant, les calculs de rendement, de meme que le pouvoir d'emanation effectif des cibles en couches epaisses, peuvent etre sensiblement influences par les donnees relatives a la periode des gaz. C'est pourquoi on a determine avec une grande precision les periodes des isotopes du krypton et du xenon, de {sup 89}Kr a {sup 93}Kr et de {sup 131}Xe a {sup 143}Xe, par une methode a courant gazeux et un procede perfectionne avec electrode chargee. Les auteurs ont effectue des mesures par l'intermediaire des produits de desintegration a longue periode deposes sur les electrodes. Le debit, le temps d'irradiation, le temps de refroidissement et les dispositions relatives au comptage on ete choisis de maniere que les mesures des divers produits de filiation soient grandement facilitees. Dans certains cas, des separations radiochimiques se sont revelees indispensables pour des raisons de selectivite. Les resultats obtenus sont les suivants: {sup 89}Kr, 3.11 {+-} 0.06 min: {sup 90}Kr, 32.1 {+-} 0.8 s; {sup 91}Kr, 8.36 {+-} 0.15 s; {sup 92}Kr, 1,92 {+-} 0.07 s; {sup 93}Kr, 1.17 {+-} 0.04 s; {sup 137}Xe, 3.87 {+-} 0.15 min; {sup 138}Xe, 14.5 {+-} 0.5 min; {sup 139}Xe, 40.4 {+-} 1.3 s: {sup 140}Xe, 13.33 {+-} 0.27s; {sup 141}Xe, 1.70 {+-} 0.05s; {sup 142}Xe, 1.15 {+-} 0.04s- et {sup 143}Xe, 0.96 {+-} 0.02s. Les auteurs ont obtenu les periodes en extrapolant les courbes de desintegration beta ou de

  10. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.

    Science.gov (United States)

    Fukushima, Henrique; Alves, Vanessa Tubero Euzebio; Carvalho, Verônica Franco de; Ambrósio, Lucas Macedo Batitucci; Eichler, Rosangela Aparecida Dos Santos; Carvalho, Maria Helena Catelli de; Saraiva, Luciana; Holzhausen, Marinella

    2017-01-26

    Recent studies investigating protease-activated receptor type 2 (PAR-2) suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF) of patients with moderate chronic periodontitis (MP). The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19) at baseline, and from MP patients (n = 19) and severe chronic periodontitis (SP) (n = 19) patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA) in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR). PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  11. Analytical methods used in plutonium purification cycles by trilaurylamine; Methodes analytiques utilisees dans les cycles de purification du plutonium par la trilaurylamine

    Energy Technology Data Exchange (ETDEWEB)

    Perez, J J [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1965-07-01

    The utilisation of trilaurylamine as a solvent extractant for the purification of plutonium has entailed to perfect a set of analytical methods which involves, various techniques. The organic impurities of the solvent can be titrated by gas-liquid chromatography. The titration of the main degradation product, the di-laurylamine, can be accomplished also by spectro-colorimetry. Potentiometry is used for the analysis of the different salts of amine-nitrate-sulfate-bisulfate as also the extracted nitric acid. The determination of the nitrate in aqueous phase is carried out by constant current potentiometry. The range of application, the accuracy and the procedure of these analysis are related in the present report. (author) [French] L'utilisation de la trilaurylamine comme solvant d'extraction pour la purification du plutonium a necessite la mise au point d'un ensemble de methodes analytiques qui ressortent de techniques diverses. Les impuretes organiques du solvant peuvent etre dosees par chromatographie gaz-liquide. Le dosage du principal produit de degradation, la dilaurylamine, peut egalement etre effectue par spectrocolorimetrie. La potentiometrie est utilisee pour les analyses des differents sels d'amine: nitrate, sulfate, bisulfate, ainsi que de l'acide nitrique extrait. La determination des nitrates en phase aqueuse est executee par potentiometrie a courant impose. Le domaine d'application, la precision et le mode operatoire de ces analyses sont indiques dans le present rapport. (auteur)

  12. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system.

    Science.gov (United States)

    Hu, Longhua; Vecchiarelli, Anthony G; Mizuuchi, Kiyoshi; Neuman, Keir C; Liu, Jian

    2015-12-22

    The segregation of DNA before cell division is essential for faithful genetic inheritance. In many bacteria, segregation of low-copy number plasmids involves an active partition system composed of a nonspecific DNA-binding ATPase, ParA, and its stimulator protein ParB. The ParA/ParB system drives directed and persistent movement of DNA cargo both in vivo and in vitro. Filament-based models akin to actin/microtubule-driven motility were proposed for plasmid segregation mediated by ParA. Recent experiments challenge this view and suggest that ParA/ParB system motility is driven by a diffusion ratchet mechanism in which ParB-coated plasmid both creates and follows a ParA gradient on the nucleoid surface. However, the detailed mechanism of ParA/ParB-mediated directed and persistent movement remains unknown. Here, we develop a theoretical model describing ParA/ParB-mediated motility. We show that the ParA/ParB system can work as a Brownian ratchet, which effectively couples the ATPase-dependent cycling of ParA-nucleoid affinity to the motion of the ParB-bound cargo. Paradoxically, this resulting processive motion relies on quenching diffusive plasmid motion through a large number of transient ParA/ParB-mediated tethers to the nucleoid surface. Our work thus sheds light on an emergent phenomenon in which nonmotor proteins work collectively via mechanochemical coupling to propel cargos-an ingenious solution shaped by evolution to cope with the lack of processive motor proteins in bacteria.

  13. The Ethanol-Chlorobenzene Aerated System as a New High-Level Dosimeter for Routine Measurements; Le Systeme Ethanol-Chlorobenzene Aere Utilise Comme Dosimetre pour les Mesures Courantes de Fortes Doses; Aehrirovannaya sistema ehtanola-khlorobenzola v kachestve novogo dozimetra vysokogo urovnya dlya provedeniya obychnykh izmerenij; Dosimetro de Etanol-Clorobenceno Saturado de Aire para la Determinacion de Intensidades Elevadas

    Energy Technology Data Exchange (ETDEWEB)

    Dvornik, I.; Zec, U.; Ranogajec, F. [Institute ' ' Ruder Boskovic' ' , Zagreb, Yugoslavia (Croatia)

    1966-11-15

    The radiolytic hydrogen chloride yield for {sup 60}Co gamma radiation measured as a function of dose (0.05 to 100 Mrad), dose-rate (0.5 to 2500 rad sec{sup -1}) and chlorobenzene (CB) concentration is found to be 5 {+-} 0.1 for CB concentrations between 20 and 40% in a broad range of experimental conditions. The yield is only slightly sensitive to normal impurities. Analytical and lower-grade components give yields reproducible within a few per cent of this value if 4% water and about 2X 10{sup -3} M benzene and acetaldehyde or acetone are initially present. Higher dosimetric accuracy is obtained if the exact G(Cl{sup -}) is determined for given materials by calibration with the Fricke dosimeter. With 4% CB and 4 Degree-Sign Inverted-Exclamation-Mark o water all grades of ethanol give G(Cl{sup -}) = 3.65 {+-} 0.05, irrespective of additives. The effect of variation of the water content within {+-} 1% is negligible. The hydrogen chloride concentration in the whole dose range is determined by mercurimetric or alkali- metric titration directly in the irradiated sample with an accuracy of one per cent or better. Incomplete experiments with fast electrons have proved that similar systems are of possible interest for calibration and control of industrial irradiations with intense electron beams. The simplicity of preparation and analysis together with the broad range (covered by only one analytical method) and high overall accuracy give to the new dosimeter all the qualities of the almost unique tool for dosimetric calibration of sources and routine control of industrial radiation processing. (author) [French] On constate que la quantite d'acide chlorhydrique radiolytique produite par des rayons gamma emis par le {sup 60}Co, mesuree en fonction de la dose (0,05 a 100 Mrad), du debit de dose (0,5 a 2500 rad-s{sup -1}) et de la concentration du chlorobenzene (CB), est de 5 {+-} 0,1 pour des concentrations de CB comprises entre 20 et 40% dans un tres large eventail de

  14. Commande hiérarchique de réseaux multi-terminaux à courant continu et haute tension

    OpenAIRE

    Jimenez Carrizosa , Miguel ,

    2015-01-01

    This thesis focuses on the hierarchical control for a multi-terminal high voltage direct current (MT-HVDC) grid suitable for the integration of large scale renewable energy sources. The proposed control scheme is composed of 4 layers, from the low local control at the power converters in the time scale of units of ms; through distributed droop control (primary control) applied in several terminals in the scale of unit of seconds; and then to communication based Model Predictive Control (MPC) ...

  15. Decontamination tests using an electrolytic method on NS 22 S stainless steel discs (1963); Essais de decontamination par voie electrolytique de plaquettes en acier inoxydable NS 22 S (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Boutot, P; Schipfer, P [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1963-07-01

    These tests were carried out with a view to observing the results obtained by using electrolytic polishing for the decontamination operations. The experimental equipment consists essentially of a current rectifier and adjuster, and of an electrolytic cell fitted with an automatic system for thermal regulation and agitation. The samples made of type NS 22 S stainless steel are contaminated with an active solution of fission products. The activity of the discs is measured before and after each treatment using a bell counter. For each electrolyte, the parameters studied are: - the time, - the reactant concentration, - the temperature, - the current density, - the corrosion. Taking into account the necessity of transforming as little as possible the surface of the part to be treated, the best results are generally obtained using intermediate concentrations of the reactant, low temperatures, and high current densities. (authors) [French] Ces essais ont ete effectues dans le but d'observer les resultats obtenus en utilisant le procede de polissage electrolytique pour les operations de decontamination. Le dispositif experimental consiste essentiellement en un redresseur-variateur de courant et en une cellule electrolytique munie d'un systeme automatique de regulation thermique et d'agitation. Les echantillons en acier inoxydable du type NS 22 S sont contamines par une solution active de produits de fission. L'activite des plaquettes est mesuree avant et apres chaque traitement au moyen d'un compteur cloche. Pour chaque electrolyte, les parametres etudies sont: - le temps, - la concentration du reactif, - la temperature, - la densite de courant, - la corrosion. En tenant compte de la necessite de transformer au minimum l'etat de surface de la piece a traiter, les resultats les meilleurs sont generalement obtenus pour des concentrations moyennes de reactif, des temperatures basses et des densites de courant elevees. (auteurs)

  16. Recherche documentaire par titrage automatique

    OpenAIRE

    Lopez , Cédric; Prince , Violaine; Roche , Mathieu

    2011-01-01

    Nous proposons dans cet article un système facilitant la recherche d'information dans un ensemble de documents textuels, basé sur le titrage (et sous-titrage) automatique. Ce dernier peut se révéler crucial, par exemple, dans le cadre de la problématique de l'accessibilité des pages web (norme W3C). Notre processus de titrage automatique consiste à extraire des syntagmes nominaux pertinents dans les textes, pouvant constituer des titres ou sous-titres candidats. Une approche originale combina...

  17. Radiation-pulse transmission via a long cable without a preamplifier and/or a pulse transformer; Transmission d'impulsions de rayonnement par cable long sans l'adjonction d'un preamplificateur ou d'un transformateur d'impulsions; Peredacha impul'snykh izluchenij no kabelyu na dal'nie rasstoyaniya bez predvaritel'nogo usileniya i/ili bez preobrazovaniya impul'sov; Transmision de impulsos por cables de gran longitud sin preamplificador y/o transformador de impulsos

    Energy Technology Data Exchange (ETDEWEB)

    Miwa, H; Tohyama, T [Kobe Kogyo Corporation, Okubo, Akashi, Hyogo (Japan)

    1962-04-15

    egalement le role de dispositif de securite. La longueur du cable reliant la resistance a l'amplificateur de courant peut atteindre 500 m, sans entrainer une distorsion de la forme des impulsions, a condition d'employer un cable coaxial et d'etablir, par le montage en serie d'une resistance variable, la correlation necessaire entre l'impedance d'entree de l'amplificateur du systeme 2 et l'impedance caracteristique du cable. En consequence, le systeme 2 a ete tres largement applique par les auteurs dans leur appareillage d'electronique nucleaire: jauge a neutrons pour la mesure de l'humidite du sol (compteur BF-3), analyseur des elements du sol (spectrometre a scintillations), jauge d'epaisseur de neige (compteur Geiger-Mueller) et appareils de controle a distance. L'absence de preamplificateur et de transformateur d'impulsions permet a ces detecteurs de fonctionner dans de mauvaises conditions ambiantes: temperatures extremes, flux intenses de neutrons (ou gamma), etc. L'emploi d'un cable coaxial unique facilite leur utilisation a grande distance. La spectroscopie a scintillation gamma n'a pas ete modifiee par la transmission des impulsions par un cable de 500 m. (author) [Spanish] Cuando se transistoriza un instrumento nuclear, es necesario modificar en parte el circuito de entrada debido a la baja impedancia de entrada que presenta. Los autores estudian y comparan entre si tres circuitos de entrada de tipo voltaje 1), de tipo voltaje-corriente 2) y de tipo corriente 3). El tipo 1) es bastante parecido a los circuitos clasicos de valvulas termoionicas. Los autores han disenado una etapa realimentada con resistencia de carga en el emisor y la han empleado con exito como circuito de entrada de elevada impedancia, superior a 10 M{Omega}, sin alterar la estabilidad de las tensiones continuas. Casi todos los detectores de radiaciones pueden ser considerados generadores de corriente. Asi pues, es posible conectar la salida de un detector a un amplificador de corriente de baja

  18. SECHAGE DE PRODUITS GRANULAIRES PAR DESHYDRATATION PAR DETENTES SUCCESSIVES (DDS)

    OpenAIRE

    Abdulla , Galal; Mellouk , Hamid; Belghit , Abdelhamid; Allaf , Karim

    2009-01-01

    International audience; Dans cette étude, nous avons évalué les performances d'un nouveau procédé de séchage dans le cas du liège en granulés. Ce procédé (La déshydratation par détentes successives : DDS) consiste à soumettre le matériau liège dans une chambre hermétique aux variations cycliques de la pression. Chaque cycle est composé d'une compression et d'une décompression. La phase de compression est réalisée en injectant de l'air comprimé à température ambiante provenant d'un compresseur...

  19. Ultrasonic Inspection following Heat Treatment of Uranium Alloys; Controle des Traitements Thermiques d'Alliage d'Uranium par Ultrasons; Kontrol' termicheskoj obrabotki uranovykh splavov s pomoshch'yu ul'trazvuka; Control Ultrasonico de los Tratamientos Termicos de Aleaciones de Uranio

    Energy Technology Data Exchange (ETDEWEB)

    Destribats, Marie-Therese; Cherpentier, C.; Papezik, F.; Pigeon, M. [Centre d' Etudes Nucleaires Desaclay (France)

    1965-10-15

    To improve the behaviour of low uranium alloys in reactors it is often necessary to reduce grain size by heat treatment. It has proved essential to provide for inspection of the whole element and the entire output in order to discover the exact quality of the fuel used. This inspection cannot be made by micrography because of the time required and the fact that the data obtained are incomplete. The inspection system adopted is based on the principle of absorption of ultrasonic waves by materials. This absorption depends on the structure of the medium. If {lambda} is small in relation to grain size G, absorption is low; whereas if G is of the order of {lambda}/2, absorption is very high. The tests were made first in air, using the multiple-echo system, then by measuring the height of the first echo, and finally by transmission in water, the height of the transmitted echo being compared with that of the initial signal. In industrial use, the amplitude of the echo transmitted by the material is compared with the echo obtained from a standard of the same characteristics and shape. Inspection takes place in a special machine in which the materials are rotated by rollers and adjustable transducers move over the element. The helicoidal scanning is carried out with a pitch of less than 5 mm. The ultrasonic generator includes a control system ensuring a constant reference echo. The paper quotes a series of records showing the results obtained with various alloys and in particular the faults observed in elements treated by induction upon linear displacement. The arrangement can detect faulty treatment zones of less than 1 cm{sup 2}. The system is at present used to inspect all low alloy uranium fuels of the G2, EL3, EDF1, EDF2 and INCA reactors, i.e. rods and tubes with diameters between 20 and 95 mm. (author) [French] Afin d'obtenir une meilleure tenue des alliages d'uranium faiblement allies dans les reacteurs, un affinage du grain par traitements thermiques est souvent

  20. Construction of the Courant-Snyder invariants for the non-linear equations of motion and criterion for the long-term stability of the beam in a storage ring

    International Nuclear Information System (INIS)

    Garczynski, V.

    1993-01-01

    The Courant-Snyder invariants become Lyapunov functions when the β-functions admit non-zero lower, and finite upper bounds. The long-term stability of motion then follows. This alternative criterion for the long-term stability of motion can be generalized to the nonlinear case. A single particle subjected to an arbitrary static magnetic field is considered in some detail, as an example

  1. Fiabilisation de la technologie courant porteur en ligne en vue de piloter des actionneurs d’aéronefs

    OpenAIRE

    Larhzaoui , Thomas

    2014-01-01

    In the new aircrafts, hydraulic flight control systems are replaced by electric flight control systems. The main interests are a better flexibility of the aeronautical equipments and a decrease in maintenance costs and construction costs, but the major problem is the increasing of the wires length. In order to decrease this length, it has been proposed to use power line communications (PLC) technology for flight control systems. The decrease of wire will first decrease aircraft weight and the...

  2. Gas detectors for thermal neutron at high counting rates; Etude des detecteurs a gaz pour neutrons thermiques fonctionnant en collection de courant

    Energy Technology Data Exchange (ETDEWEB)

    Mai, V Q [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1965-09-01

    After reminding of the current pulse formation theory in a cylindrical shape counter with and without gas multiplication, one gives the schemes of pulse amplifier and level discriminator which have allowed to verify the above calculations and to make clear the part at high counting rates of the space charge in proportional counters. The theory of that phenomenon is given in chapter V I at last, one gives the results obtained in a nuclear reactor with a counting-channel built with the above electronics circuits. (author) [French] Apres avoir rappele la theorie de la formation de l'impulsion de courant dans un compteur a geometrie cylindrique, fonctionnant sans et avec multiplication de charge, on etudie l'amplificateur et le discriminateur qui ont permis de verifier experimentalement les calculs precedents et de mettre en evidence l'action de la charge d'espace dans les compteurs proportionnels fonctionnant a tres fort taux de comptage. Une theorie de ce phenomene est donnee au chapitre VI; on indique enfin les resultats obtenus dans un reacteur avec une chaine de comptage utilisant les circuits electroniques precedents. (auteur)

  3. LNS users primer for accessing government sites on the ARPA network. [MIT. -->. ANL, BNL, LBL, and New York Univ. Courant Inst

    Energy Technology Data Exchange (ETDEWEB)

    Kannel, M.

    1979-06-01

    This primer was developed as part of the study conducted by the Laboratory for Nuclear Science (LNS) on the feasibility of networks for computer resource sharing. The primer is an instructinal guide for the LNS user who would like to access and use computers at other government sites on the ARPA network. The format is a series of scenarios of actual recorded on-line terminal sessions' showing the novice user how to access the foreign site, obtain help documentation, run a simple program, and transfer files to and from the foreign site. Access to the ARPA network in these scenarios is via Multics or the Massachusetts Institute of Technology Terminal Interface Processor. The foreign government sites accessed are the computing facilities at Argonne National Laboratory, Brookhaven National Laboratory, Lawrence Livermore Laboratory, and New York University Courant Institute. This technique of auditing actual terminal sessions as a teaching aid can be extended to include other computing facilities as well as other networks.

  4. Study of gas-solid contact in an ultra-rapid reactor for cumene catalytic cracking; Etude du contact gaz-solide dans un reacteur a co-courant descendant par la mise en oeuvre du craquage catalytique du cumene

    Energy Technology Data Exchange (ETDEWEB)

    Bayle, J

    1996-11-05

    Few studies have been carried out on the notion of gas-solid contact in ultra-rapid reactors. Both gas and solid move in the reactor and the contact can be directly estimated when using a chemical reaction such as cumene cracking. It`s a pure and light feedstock whose kinetics can be determined in a fixed bed. The study was carried out on a downflow ultra-rapid reactor (ID = 20 mm, length = 1 m) at the University of Western Ontario. It proved that the quench and the ultra-rapid separation of gas and solid must be carefully designed in the pilot plant. Cumene conversion dropped when reducing gas-solid contact, which led to push the temperature over 550 deg. C and increase the cat/oil ratio at 25 working at solid mass fluxes below 85 kg/m{sup 2}.s. Change of selectivity at very short residence time were also observed due to deactivation effects. Experiments made by Roques (1994) with phosphorescent pigments on the Residence Time Distribution of solids gave Hydrodynamic data on a cold flow copy of the pilot plant. Experiments made on packed bed gave kinetic data on the cracking of cumene. These data were combined to optimize a mono dimensional plug flow model for cumene cracking. (author)

  5. La preuve par le nombre

    Directory of Open Access Journals (Sweden)

    Hélène Verdier

    2012-04-01

    Full Text Available S’il en était besoin, la question des usages et de la finalité des résultats de l’inventaire général pourrait être abordée par le nombre : nombre d’œuvres répertoriées, de communes inventoriées, de clichés photographiques réalisés, de dossiers, de consultations des notices dans les bases de données… Les additions aujourd’hui sont éloquentes, mais elles laissent dans l’ombre le rôle de l’inventaire qui, en mettant en œuvre une démarche systématique de connaissance, participe à l’ identificatio...

  6. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  7. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-01-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  8. ¡París!

    Directory of Open Access Journals (Sweden)

    Beatriz Caballero

    2003-01-01

    Full Text Available El día no le alcanzaba para caminarlo. Conocía cada puente, cada calle,plaza, museo, rincón, iglesia, café, y la mesa con el mejor ángulo para mirar siempre una iglesia, ojalá Saint-Germain-des-Pres, o Notre-Dame. Siempre contaba la impresión que le había causado a Bolívar ver allí cuando el papa coronó a Napoleón. Él se iba para la oficina todos los días, Luis a un taller a pintar, Antonio a estudiar ciencias políticas, yo al colegio y mamá hacía las cosas prácticas. Aprendíamos francés todos al tiempo y por la noche nos contábamos lo nuevo que cada uno había aprendido. Mamá después, cuando ya se quería volver, decía que París nos había maleado a todos. Estaba en pleno furor el cine francés de la "nueva ola", pero ella sólo me llevaba a ver películas de vaqueros pues no se fiaba de la clasificación de los periódicos.

  9. Control of the electrical operating point of an electric discharge by mean of its power supply; Controle du point de fonctionnement des decharges electriques par l'intermediaire de leur alimentation

    Energy Technology Data Exchange (ETDEWEB)

    Salanne, J.Ph.

    2005-11-15

    The operating points obtained by the coupling of the power supply with the electric discharge system can be unstable because of the dynamical behaviour of the discharge or because of a change in its length. In this work, the different possible couplings existing between the discharge and the characteristics of its power supply are analyzed in order to optimize the design and control of the power supply and to control the operating point. Analytical and numerical modeling of the system are proposed which allow to simulate the couplings between the power supply and the discharge. This approach is completed by experimental investigations allowing to consider the cases of peak/peak discharges, dielectric barrier discharges (DBD), and gliding arcs. (J.S.)

  10. Positron Accumulator Ring (PAR) power supply

    International Nuclear Information System (INIS)

    Fathizadeh, M.

    1995-01-01

    The Positron Accumulator Ring (PAR) consists of 8 dipole magnets connected in series. These magnets are energized via one 12-pulse dc power supply. The power supply consists of four phase controlled half-wave wye group converters. Each of the two half-wave converters are connected through an interphase transformer to obtain a full-wave converter with 120 degrees conduction. The input voltage for these two half-wave converters are 180 degrees apart. The two full-wave converters are connected in parallel through a third interphase transformer. This type of connection of the converters not only provides the required output current, it also improves the input power factor of the power supply. The output of the wye group converters is filtered through a passive L-R-C filter to reduce the ripple content of the output current. At low current values of the power supply the current ripple is high, thus a large filter is needed, which adds to the cost of the power supply, however at high output current levels, the current ripple is less severe. The large size of the filter can be reduced by adding an anti-parallel rectifier diode(D1) to the output of the power supply. A freewheeling diode(D2) is connected before the choke to circulate the current once the power supply is turned off. In order to measure the current in the magnet a high precision, low drift, zero flux current transductor is used. This transductor senses the magnet current which provides a feedback signal to control the gating of the converter's thyristors. A true 14 bit Digital to Analog Converter (DAC) is programmed by the control computer for the required current value, providing a reference for the current regulator. Fast correction of the line transients is provided by a relatively fast voltage loop controlled by a high gain slow response current loop

  11. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  12. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  13. La diversité vue par un journal communautaire maghrébin à Montréal

    Directory of Open Access Journals (Sweden)

    Rachad Antonius

    2009-01-01

    Full Text Available Cet article se situe dans le champ d’étude des médias “communautaires” ou ethniques. Il analyse la couverture, par le journal communautaire maghrébin Atlas.Mtl, de la question de la diversité au Québec. L’analyse montre qu’Atlas.Mtl s’inscrit dans une logique de négociation des rapports de force entre les citoyens d’origine maghrébine et le groupe majoritaire, dans le cadre d’un système hégémonique dont il ne conteste pas les fondements. Son approche est non conflictuelle, et le journal adopte un ton généralement conciliant qui ne rejette pas globalement les avantages d’un système libéral et laïque, contrastant ainsi avec d’autres journaux plus radicaux dans leurs revendications. On y trouve une ouverture à la diversité d’opinions. En dehors des périodes de tension sociale où le discours sur l’immigration et sur la diversité s’est durci, le contenu du journal revient à un ton moins revendicateur. Son apport se situe davantage au niveau de l’information qu’à celui de la revendication, avec une préoccupation claire pour la modification des situations d’inégalité. Il s’en dégage une orientation générale qui propose une identité arabo-musulmane laïque, modérée et libérale, spécifiquement maghrébine, assumant son appartenance à une société québécoise laïque, et faisant partie de la diaspora internationale maghrébine. Nous situerons cette orientation dans les débats entre le courant des études post-coloniales et les courants qui insistent sur les orientations économiques et intégrationnistes des médias ethniques minoritaires, et nous proposerons des interprétations du positionnement du journal qui font référence au grand débat entre islamisme et nationalisme laïque dans les pays arabes.

  14. Experimental study about the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin

    Directory of Open Access Journals (Sweden)

    Hui-Lin Mao

    2017-11-01

    Full Text Available Objective: To study the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin. Methods: Nephroblastoma SK-NEP-1 cells were cultured and divided into four groups, control group were treated with RMPI-1640 without serum or drugs, cisplatin group were treated with serum-free RMPI-1640 containing 5 μg/mL cisplatin, Par-4 group were transfected by Par-4 overexpression plasmids with serum-free RMPI-1640, and cisplatin + Par-4 group were transfected by Par-4 overexpression plasmid with serum-free RMPI-1640 containing 5 μg/mL cisplatin. The cell proliferation activity as well the expression of apoptosis genes, migration genes and invasion genes was measured. Results: 8 h, 16 h and 24 h after different conditions of treatment, the cell proliferation activity of cisplatin group, Par-4 group and cisplatin + Par-4 group were significantly lower than that of control group, and the cell proliferation activity of cisplatin + Par-4 group was significantly lower than that of cisplatin group and Par-4 group; 24 h after different conditions of treatment, Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin group, Par-4 group and cisplatin + Par-4 group were greatly higher than those in control group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly lower than those in control group; Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin + Par-4 group were greatly higher than those in cisplatin group and Par-4 group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly significantly lower than those in cisplatin group and Par-4 group. Conclusion: Par-4 gene overexpression can increase the nephroblastoma sensitivity to cisplatin, reduce cell proliferation activity, promote apoptosis and inhibit cell migration and invasion.

  15. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer.

    Science.gov (United States)

    Hau, Andrew M; Leivo, Mariah Z; Gilder, Andrew S; Hu, Jing-Jing; Gonias, Steven L; Hansel, Donna E

    2017-01-01

    Mammalian target of rapamycin complex 2 (mTORC2) has been identified as a major regulator of bladder cancer cell migration and invasion. Upstream pathways that mediate mTORC2 activation remain poorly defined. Urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored membrane protein and known activator of cell-signaling. We identified increased uPAR expression in 94% of invasive human bladder cancers and in 54-71% of non-invasive bladder cancers, depending on grade. Normal urothelium was uPAR-immunonegative. Analysis of publicly available datasets identified uPAR gene amplification or mRNA upregulation in a subset of bladder cancer patients with reduced overall survival. Using biochemical approaches, we showed that uPAR activates mTORC2 in bladder cancer cells. Highly invasive bladder cancer cell lines, including T24, J82 and UM-UC-3 cells, showed increased uPAR mRNA expression and protein levels compared with the less aggressive cell lines, UROtsa and RT4. uPAR gene-silencing significantly reduced phosphorylation of Serine-473 in Akt, an mTORC2 target. uPAR gene-silencing also reduced bladder cancer cell migration and Matrigel invasion. S473 phosphorylation was observed by immunohistochemistry in human bladder cancers only when the tumors expressed high levels of uPAR. S473 phosphorylation was not controlled by uPAR in bladder cancer cell lines that are PTEN-negative; however, this result probably did not reflect altered mTORC2 regulation. Instead, PTEN deficiency de-repressed alternative kinases that phosphorylate S473. Our results suggest that uPAR and mTORC2 are components of a single cell-signaling pathway. Targeting uPAR or mTORC2 may be beneficial in patients with bladder cancer. Copyright © 2016. Published by Elsevier Inc.

  16. Special Nuclear Material Control by the Power Reactor Operator; Controle des Matieres Nucleaires Speciales par l'Exploitant d'une Centrale Nucleaire; Spetsial'nyj kontrol' nalichiya yadernykh materialov operatorom ehnergeticheskogo reaktora; Control de Materiales Nucleares Especiales por Parte de Quienes Operan el Reactor de Potencia

    Energy Technology Data Exchange (ETDEWEB)

    Cordin, R. A. [Yankee Atomic Electric Company, Boston, MA (United States)

    1966-02-15

    insurance programme. (author) [French] L'uranium, combustible relativement nouveau et extremement interessant pour la production d'electricite, doit faire l'objet d'un controle tres strict depuis le moment ou l'exploitant de la centrale en devient financierement responsable jusqu'a celui oti, sous forme de combustible partiellement epuise, la matiere est transferee dans une autre installation et oti l'on recupere ce qui reste de sa valeur initiale. La plupart des exploitants de centrales nucleaires dirigeaient des centrales alimentees par des combustibles fossiles avant l'avenement de l'energie nucleaire et ils ont etabli depuis longtemps un controle etendu et efficace de ces combustibles fossiles. L'exploitant d'une centrale nucleaire doit exercer un controle non moins efficace sur les matieres nucleaires speciales utilisees dans son installation. La technique de l'exploitation des centrales nucleaires n'est pas ancienne et, au cours de, son existence relativement breve, les ingenieurs et hommes de science des Etats-Unis ont constamment ameliore les plans des centrales et les methodes d'exploitation afin de reduire les couts et de permettre aux centrales nucleaires de concurrencer les centrales classiques. La gestion des matieres nucleaires doit etre aussi moderne et efficace que possible pour assurer que les progres technologiques grace auxquels les prix on pu etre reduits ne soient pas mis en echec par des insuffisances dans la manipulation du combustible nucleaire et la tenue de la comptabilite des stocks. Pour assurer la gestion des matieres nucleaires, il faut que l'exploitant de la centrale etablisse et tienne a jour une comptabilite complete et detaillee, sans etre necessairement complexe pour autant; en fait, la simplicite est extremement souhaitable. Bien que le combustible nucleaire soit nouveau et qu'il n'ait rien de commun avec les combustibles classiques, aucun secret ne doit s'y attacher. Le controle des matieres nucleaires dans le cadre de la gestion des

  17. Microhabitats utilisés par les alevins 0+ d'une communauté de cyprins rhéophiles : analyse de l'évolution de la communauté et des densités de population

    Directory of Open Access Journals (Sweden)

    BARAS E.

    1995-04-01

    Full Text Available L'évolution de l'occupation des microhabitats par les alevins de la communauté de cyprins rhéophiles de l'Ourthe a été étudiée au cours de l'été et de l'automne 1994 par échantillonnage ponctuel d'abondance (électrodes fixes prépositionnées, courant continu. 16155 poissons (10-75 mm appartenant à 15 espèces ont été recensés sur 78 sites d'échantillonnage de 2 m2 . Les espèces les plus représentées étaient Leuciscus cephalus, Leuciscus leuciscus et Chondrostoma nasus (respectivement 43,6 %, 20,7 % et 16,7 % des captures estivales. L'analyse factorielle des correspondances d'une matrice site x (espèce x taille met en évidence une subdivision progressive de la communauté au cours de l'été en espèces d'eau vive (B. barbus et L. leuciscus et d'eau lente, davantage associées à un couvert végétal (L. cephalus et C. nasus. La densité maximale observée (fin juin est de 1500 alevins (25 mm m-2, correspondant à une biomasse de 250 g m-2. Le modèle explicatif de la densité généré par analyse de régression multiple pas-à-pas explique 60,0 % de la variabilité de la densité par les variables vitesse de courant, température de l'eau et date d'échantillonnage, cette variable intégrant le concept de mortalité-dispersion au cours de la saison de croissance. Les implications de la méthodologie et des résultats présentés au plan de la gestion des écosystèmes lotiques sont brièvement discutés.

  18. Application of passive auto catalytic recombiner (PAR) for BWR plants in Japan

    International Nuclear Information System (INIS)

    Kobayashi, K.; Murano, K.; Yamanari, S.; Yamamoto, Y.

    2001-01-01

    The passive auto-catalytic recombiner (PAR), which can recombine flammable gases such as hydrogen and oxygen with each other to avoid an explosion in case of a loss-of-coolant accident (LOCA), installed in the primary containment vessel does not require a power supply or dynamic equipment, while the existing flammability gas control system (FCS) of most BWRs as an outer loop of the primary containment vessel needs them to make flammable gases circulate through blowers and heaters in the system. PAR offers a number of advantages over existing FCS, such as high reliability, low cost due to much smaller amount of materials needed, good maintainability, good operability in case of a LOCA, and smaller space for installation. An experimental study has been carried out for the purpose of solving the problems of applying PAR to Japanese BWR plants instead of existing FCS, in which we grasped the basic characteristics of PAR. (author)

  19. Preliminary Analysis For Wolsong Par Effects Using ISACC Calculations

    International Nuclear Information System (INIS)

    Song, Yong Mann; Kim, Dong Ha

    2012-01-01

    In the paper, hydrogen control effects using PARs only are analyzed for severe SBO station blackout (SBO) sequences beyond the design basis accidents in WS-1 which are of CANDU6 type reactor. As a computational tool, the latest version of ISAAC4.3 (Integrated Severe Accident Analysis Code for CANDU), which is a fully integrated and lumped severe accident computer code, is used to simulate hydrogen generation and transport inside the reactor building (R/B) before its failure. For the performance of hydrogen removal, the depletion rate equation of K-PAR developed in Korea is applied. In a CANDU reactor, three areas are identified as sources of hydrogen under severe accidents: fuel-coolant interactions in intact channels, suspended fuel or debris interactions in-calandria tank and debris interactions in-calandria vault. The first two origins provide source for the late ('late' terminology is used because it takes more than one day before calandria tank failure) potential hydrogen combustion before calandria tank failure and all the three origins would provide source for the very late potential hydrogen combustion occurring at or after calaria tank failure. If the hydrogen mitigation system fails, the AICC (adiabatic isochoric complete combustion) burning of highly flammable hydrogen may cause Wolsong R/B failure. So hydrogen induced failure possibility is evaluated, using preliminary ISAAC calculations, under several SBO conditions with and without PAR for both late and very late accident periods

  20. The reprocessing of irradiated fuels by halides and their compounds; Le traitement des combustibles irradies par les halogenes et leurs composes

    Energy Technology Data Exchange (ETDEWEB)

    Bourgeois, M; Faugeras, P [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    A brief description is given of the experiments leading to the choice of the process volatilization of fluorides by gas phase attack. The chemical process is described for certain current types of clad Fuels: the aluminium or the zirconium cladding is first volatilized as chloride by attack with gaseous hydrogen chloride. The uranium is then transformed into volatile hexafluoride by attack with fluorine. These reactions are carried out consecutively in the same reactor in the presence of a fluidized bed of alumina which facilitates heat exchange. The experiments have been carried out in quantities from 100 gms to several kilograms of fuel, first without activity, and then with tracers. A description is given of the laboratory research which was carried out simultaneously on the separation of uranium and plutonium fluorides. Finally, an apparatus is described which is intended to test the process on irradiated fuel at an activity level of several thousands of curies of fission products. (authors) [French] On rappelle brievement les experimentations qui nous ont permis de decider du procede adopte volatilisation des fluorures par attaque en phase gazeuse. On decrit le processus chimique pour certains types courants de combustibles Gaines: dans un premier stade, l'aluminium ou le zirconium est volatilise sous forme de chlorure par action de l'acide chlorhydrique. Ensuite, l'uranium est transforme en hexafluorure volatil par action du fluor. Ces operations se font successivement dans un meme reacteur, en presence d'un lit fluidise d'alumine qui a pour but de faciliter les echanges thermiques. L'experimentation a ete conduite sur des quantites allant de 100 g a plusieurs kg de combustibles, en inactif, puis avec des traceurs. On decrit les etudes de laboratoire menees parallelement sur la separation des fluorures d'uranium et de plutonium. Enfin, on decrit une installation en construction destinee a experimenter le procede sur combustible irradie, a l'echelle de

  1. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    NARCIS (Netherlands)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced

  2. Industrial Ultrasonic Inspection of Stainless-Steel Claddings for the EL4 Reactor; Controle Industriel par Ultrasons des Gaines en Acier Inoxydable du Reacteur EL4; Promyshlennyj kontrol' obolochechnykh trub iz nerzhaveyushchej stali reaktora dlya EL4 s pomoshch'yu ul'trazvukovogo metoda; Metodos Ultrasonicos para Control Industrial de las Vainas de Acero Inoxidable del Reactor EL4

    Energy Technology Data Exchange (ETDEWEB)

    Prot, A. C.; Foulquoer, H. E.; Peyrot, J. P. [Centre d' Etudes Nucleaires de Saclay (France)

    1965-09-15

    essentiel de rentabilite du reacteur. Il s'avere que le choix de la methode a utiliser et a mettre au point est delicat; le memoire en donne les elements essentiels. Ce choix etant fait, apres mise au point en laboratoire, deux nouveaux problemes se posent: - la transposition dans le domaine industriel; - la necessite de tenir compte de la qualite permise, a un instant determine, par les procedes de fabrication, en relation avec les normes de reception definies de maniere plus ou moins arbitraire. Ceci se traduit en fait par la necessite d'une etude statistique sur des lots de tubes de diverses provenances, et leur classement par rapport a des seuils plus ou moins severes. On verra que le nombre de tubes a controler est tres superieur a celui prevu initialement. Cela conduit a l'etude d'une machine de controle automatique, capable de satisfaire a la fois les exigences de cadence et celles propres au type de controle choisi: ces dernieres sont generalement d'ordre mecanique et necessitent une construction particulierement soignee. L'ensemble de ces considerations a conduit a concevoir une machine dont la cadence peut des maintenant couvrir sans difficulte les besoins d'une chaihe de fabrication d'elements combustibles. Les possibilites de cette machine sont etroitement liees aux caracteristiques du materiel de controle choisi, en particulier aux performances de l'electronique des appareils de controle par ultrasons et a celles des traducteurs utilises. Il resulte d'ailleurs de cette etude que le materiel standard ne repond que tres imparfaitement au probleme et que l'on doit envisager des maintenant un appareillage particulier pour ce type de controle. (author) [Spanish] Las mayores exigencias a que se someten los reactores obligan a utilizar materiales elaborados y controlados con sumo cuidado. Un aspecto de tal control se refiere a la calidad de las vainas empleadas, cuyas propiedades mecanicas ejercen una influencia decisiva sobre la rentabilidad del reactor. La eleccion

  3. Effect of a physical activity intervention on suPAR levels

    DEFF Research Database (Denmark)

    Rohde, Christopher; Polcwiartek, Christoffer; Andersen, Eivind

    2018-01-01

    OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS......: suPAR and C-reactive protein (CRP) levels were determined in blood samples from a previous randomized controlled trial with Pakistani immigrants in Norway, 2008. The study included physically inactive men that were randomized to an intervention group (supervised group exercises) or a control group...... and followed for 5 months. A linear regression model was used and adjusted for age, inactivity level at baseline, and mean difference in CRP levels. RESULTS: Overall, 80 and 53 participants were included in the intervention and control group, respectively. Obesity and smoking were associated with higher su...

  4. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1 in breast cancer invasion: signaling partners, hierarchy and physiological significance.

    Directory of Open Access Journals (Sweden)

    Irit Cohen

    Full Text Available BACKGROUND: While protease-activated-receptor 1 (PAR(1 plays a central role in tumor progression, little is known about the cell signaling involved. METHODOLOGY/PRINCIPAL FINDINGS: We show here the impact of PAR(1 cellular activities using both an orthotopic mouse mammary xenograft and a colorectal-liver metastasis model in vivo, with biochemical analyses in vitro. Large and highly vascularized tumors were generated by cells over-expressing wt hPar1, Y397Z hPar1, with persistent signaling, or Y381A hPar1 mutant constructs. In contrast, cells over-expressing the truncated form of hPar1, which lacks the cytoplasmic tail, developed small or no tumors, similar to cells expressing empty vector or control untreated cells. Antibody array membranes revealed essential hPar1 partners including Etk/Bmx and Shc. PAR(1 activation induces Etk/Bmx and Shc binding to the receptor C-tail to form a complex. Y/A mutations in the PAR(1 C-tail did not prevent Shc-PAR(1 association, but enhanced the number of liver metastases compared with the already increased metastases obtained with wt hPar1. We found that Etk/Bmx first binds via the PH domain to a region of seven residues, located between C378-S384 in PAR(1 C-tail, enabling subsequent Shc association. Importantly, expression of the hPar1-7A mutant form (substituted A, residues 378-384, which is incapable of binding Etk/Bmx, resulted in inhibition of invasion through Matrigel-coated membranes. Similarly, knocking down Etk/Bmx inhibited PAR(1-induced MDA-MB-435 cell migration. In addition, intact spheroid morphogenesis of MCF10A cells is markedly disrupted by the ectopic expression of wt hPar1. In contrast, the forced expression of the hPar1-7A mutant results in normal ball-shaped spheroids. Thus, by preventing binding of Etk/Bmx to PAR(1 -C-tail, hPar1 oncogenic properties are abrogated. CONCLUSIONS/SIGNIFICANCE: This is the first demonstration that a cytoplasmic portion of the PAR(1 C-tail functions as a scaffold

  5. Avaliação de parâmetros clínicos e hematológicos de eqüinos submetidos a um programa de controle estratégico de Amblyomma cajennense (Fabricius, 1787 (Acari: Ixodidae Evaluation of clinical and hematological parameters of equines submitted to a strategic control program of Amblyomma cajennense (Fabricius, 1787 (Acari: Ixodidae

    Directory of Open Access Journals (Sweden)

    A.P. Cunha

    2008-02-01

    Full Text Available Estudaram-se aspectos clínicos e hematológicos em eqüinos submetidos a um programa de controle estratégico de A. cajennense. Os tratamentos carrapaticidas foram realizados a cada sete dias e divididos em dois módulos, o primeiro com início em abril de 2004, e o segundo com início em julho do mesmo ano, utilizando-se a base química piretróide - cipermetrina na concentração de 0,015%. Além do acompanhamento clínico dos animais, foram realizados hemogramas completos antes e após o programa. As dosagens bioquímicas de bilirrubinas, gama-glutamiltransferase (GGT, aspartato aminotransferase (AST, creatina kinase (CK, proteína total, albumina e globulinas, foram realizadas antes, durante e ao final do programa. Os resultados demonstraram que houve uma melhora no quadro hematológico dos animais após o programa de controle. Os tratamentos carrapaticidas, na forma em foram aplicados, não provocaram alterações desfavoráveis nos parâmetros clínicos e hematológicos dos eqüinos. Tais informações podem ser consideradas na busca de alternativas viáveis e seguras para o controle dessa espécie de carrapato.Clinical and hematological parameters were studied in equines submitted to a strategic control program of Amblyomma cajennense. The acaricide treatments were carried to each seven days and divided in two batteries, the first one began in April 2004 and the second in July 2004. A pyrethroid chemical base - 0.015% cypermethrin was used. Clinical examinations of the animals and complete hemograms were carried before and after the control program of the tick. Seric dosages of bilirrubins, gamma-glutamiltransferase (GGT, aspartate aminotransferase (AST, creatin kinase (CK, total protein, albumin, and globulins, were carried before and throughout the experiment. The results showed an improvement in the hematological parameters of the animals after the end of control program. The acaricide treatments did not cause undesirable alterations

  6. uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells.

    Science.gov (United States)

    Laurenzana, Anna; Chillà, Anastasia; Luciani, Cristina; Peppicelli, Silvia; Biagioni, Alessio; Bianchini, Francesca; Tenedini, Elena; Torre, Eugenio; Mocali, Alessandra; Calorini, Lido; Margheri, Francesca; Fibbi, Gabriella; Del Rosso, Mario

    2017-09-15

    In this manuscript, we show the involvement of the uPA/uPAR system in the regulation of aerobic glycolysis of melanoma cells. uPAR over-expression in human melanoma cells controls an invasive and glycolytic phenotype in normoxic conditions. uPAR down-regulation by siRNA or its uncoupling from integrins, and hence from integrin-linked tyrosine kinase receptors (IL-TKRs), by an antagonist peptide induced a striking inhibition of the PI3K/AKT/mTOR/HIF1α pathway, resulting into impairment of glucose uptake, decrease of several glycolytic enzymes and of PKM2, a checkpoint that controls metabolism of cancer cells. Further, binding of uPA to uPAR regulates expression of molecules that govern cell invasion, including extracellular matrix metallo-proteinases inducer (EMPPRIN) and enolase, a glycolytyc enzyme that also serves as a plasminogen receptor, thus providing a common denominator between tumor metabolism and phenotypic invasive features. Such effects depend on the α5β1-integrin-mediated uPAR connection with EGFR in melanoma cells with engagement of the PI3K-mTOR-HIFα pathway. HIF-1α trans-activates genes whose products mediate tumor invasion and glycolysis, thus providing the common denominator between melanoma metabolism and its invasive features. These findings unveil a unrecognized interaction between the invasion-related uPAR and IL-TKRs in the control of glycolysis and disclose a new pharmacological target (i.e., uPAR/IL-TKRs axis) for the therapy of melanoma. © 2017 UICC.

  7. Study of current instabilities in high resistivity gallium arsenide; Etude des instabilites de courant dans l'arseniure de gallium de haute resistivite

    Energy Technology Data Exchange (ETDEWEB)

    Barraud, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    We have shown the existence and made a study of the current oscillations produced in high-resistivity gallium arsenide by a strong electric field. The oscillations are associated with the slow travelling of a region of high electrical field across the whole sample. An experimental study of the properties of these instabilities has made it possible for us to distinguish this phenomenon from the Gunn effect, from acoustic-electric effects and from contact effects. In order to account for this type of instability, a differential trapping mechanism involving repulsive impurities is proposed; this mechanism can reduce the concentration of charge carriers in the conduction band at strong electrical fields and can lead to the production of a high-field domain. By developing this model qualitatively we have been able to account for all the properties of high-resistance gallium arsenide crystals subjected to a strong electrical field: increase of the Hall constant, existence of a voltage threshold for these oscillations, production of domains of high field, low rate of propagation of these domains, and finally the possibility of inverting the direction of the propagation of the domain without destroying the latter. A quantitative development of the model makes it possible to calculate the various characteristic parameters of these instabilities. Comparison with experiment shows that there is a good agreement, the small deviations coming especially from the lack of knowledge concerning transport properties in gallium arsenide subjected to high fields. From a study of this model, it appears that the instability phenomenon can occur over a wide range of repulsive centre concentrations, and also for a large range of resistivities. This is the reason why it appears systematically in gallium arsenide of medium and high resistivity. (authors) [French] Nous avons mis en evidence et etudie des oscillations de courant qui se produisent a champ electrique eleve dans l'arseniure de

  8. ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation

    Science.gov (United States)

    Donczew, Magdalena; Mackiewicz, Paweł; Wróbel, Agnieszka; Flärdh, Klas; Zakrzewska-Czerwińska, Jolanta

    2016-01-01

    In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces. To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at the time of ParA accumulation and Z-ring formation. We demonstrated that both ParA and ParB affect the rate of hyphal extension. Additionally, we showed that ParA promotes the formation of massive nucleoprotein complexes by ParB. We also showed that FtsZ ring assembly is affected by the ParB protein and/or unsegregated DNA. Our results indicate the existence of a checkpoint between the extension and septation of sporogenic hyphae that involves the ParA and ParB proteins. PMID:27248800

  9. Contamination potentielle des aliments par des ...

    African Journals Online (AJOL)

    SARA Computers

    la notion de la pollution et de l'exposition aux PCBs, lorsque 77% n'ont pas conscience de cette situation de risque ... 2018). Quoique la contamination par les. PCBs soit de faible niveau, elle est ...... Université Paris-Est, Paris, France ; 183.

  10. CFD analysis of PAR performance as function of inlet design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical and Energy systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University (Korea, Republic of)

    2016-01-15

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  11. CFD analysis of PAR performance as function of inlet design

    International Nuclear Information System (INIS)

    Park, Kweonha; Khor, Chong Lee

    2016-01-01

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  12. Efficacy and safety of the pars plana clip in the Ahmed valve device inserted via the pars plana in patients with refractory glaucoma

    Directory of Open Access Journals (Sweden)

    Manuel Diaz-Llopis

    2010-05-01

    Full Text Available Manuel Diaz-Llopis1,2,3, David Salom1,3, Salvador García-Delpech1,2,3, Patricia Udaondo1,3, Jose Maria Millan3,5, J Fernando Arevalo61Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain; 2Department of Ophthalmology of the Valencia University, Valencia, Spain; 3Biomedical Network Research Centre on Rare Diseases (CIBERER, Valencia, Spain; 4Catholic University San Vicente Martir, Valencia, Spain; 5Department of Genetics, La Fe University Hospital of Valencia, Valencia, Spain; 6Clinica Oftalmologica Centro Caracas, Retina and VItreous Service, Caracas, DC, VenezuelaPurpose: To evaluate the efficacy and safety of the pars plana clip (PPC in the Ahmed valve tube inserted via the pars plana in patients with secondary refractory glaucomas.Methods: Prospective and interventional case series that included 10 patients with secondary refractory glaucoma. The pars plana vitrectomy and the implant of the modified tube were performed during the same surgery. Control of intraocular pressure (IOP and the development of intra- and postoperative complications were evaluated during the follow-up.Results: Follow-up time was twelve months in all the patients. Control of IOP was achieved in 90% of patients, and 70% needed no antiglaucoma treatment. The complications that occurred were transient hypotony in three cases, choroidal detachment in two cases, and one case of intraocular hemorrhage. No case of tube extrusion or tube kink was observed.Conclusions: Our data suggests that implantation of the Ahmed tube modified with the PPC via the pars plana is safe and effective in patients with secondary refractory glaucomas. Keywords: pars plana clip, Ahmed valve, refractory glaucoma, pars plana vitrectomy

  13. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...

  14. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  15. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable inflammatory biomarker. In patients, suPAR is a marker of disease presence, severity and prognosis. In the general population, suPAR is predictive of disease development, such as diabetes and cardiovascular disease a...

  16. Copenhagen uPAR prostate cancer (CuPCa) database

    DEFF Research Database (Denmark)

    Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

    2016-01-01

    AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS...

  17. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

    2015-01-01

    . This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...

  18. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Science.gov (United States)

    Baronian, Grégory; Ginda, Katarzyna; Berry, Laurence; Cohen-Gonsaud, Martin; Zakrzewska-Czerwińska, Jolanta; Jakimowicz, Dagmara; Molle, Virginie

    2015-01-01

    Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  19. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Directory of Open Access Journals (Sweden)

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  20. Confinement of a non cylindrical z discharge by a cusp geometry; Confinement d'une decharge lineaire non-cylindrique par une geometrie magnetique cuspidee

    Energy Technology Data Exchange (ETDEWEB)

    Watteau, J H [Commissariat a l' Energie Atomique, Limeil-Brevannes (France). Centre d' Etudes

    1968-03-01

    The plasma of a non-cylindrical z discharge is accumulated in the centre of a cusp geometry and then captured and confined by the rising cusp magnetic field. The cusp geometry is produced by two identical coaxial coils the currents of which are equal but in opposite directions. Stability and confinement properties of this zero minimum B geometry are recalled; in particular it is shown (the coils cross section being supposed punctual) that the magnetic well depth of the configuration without plasma is maximum for an optimum coils distance. Two modes of confinement are observed experimentally : - a collisional mode for which the plasma confinement is limited to 10 {mu}sec (temperature 5 eV, density 7 x 10{sup 16} cm{sup -3}) as a result of the gradual interpenetration of the plasma and of the magnetic field. - a collisionless mode (temperature 40 eV) where the radial leak thickness is of the order of the ion cyclotron radius. Plasma accumulation occurs even without confinement and is due to the non-cylindrical shape of the discharge chamber. The two-dimensional snow-plough model gives good account of the discharge dynamics. A comparison is made with plasma focus experiments: in particular experimental conditions (deuterium, pressure 1 torr,energy 3 kJ, current 100 kA) a 10{sup 7} neutron yield is detected which appears to be connected with the unstable behavior of the discharge. (authors) [French] Le plasma d'une decharge lineaire non-cylindrique s'accumule au centre d'une geometrie magnetique cuspidee ou il est capture et confine par l'induction croissante de la geometrie. On rappelle les proprietes de stabilite et de confinement de la geometrie cuspidee, geometrie a champ minimum nul produite par deux spires identiques, coaxiales et parcourues par des courants egaux et opposes; on montre en particulier que pour des spires de section ponctuelle la profondeur du puits magnetique de la geometrie sans plasma est maximum pour une distance optimum des spires. Deux

  1. [Ambroise Paré in French literature].

    Science.gov (United States)

    Dumaitre, P

    1995-01-01

    The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.

  2. Par Pond refill water quality sampling

    International Nuclear Information System (INIS)

    Koch, J.W. II; Martin, F.D.; Westbury, H.M.

    1996-08-01

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column

  3. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly......, hence identifying the N terminus of ParB as a requirement for ParB-mediated centromere pairing. These observations suggest that centromere pairing is an important intermediate step in plasmid partitioning mediated by the common type I loci....

  4. Una introducción al ajuste de parámetros de controladores PI utilizados en el control del generador de inducción con rotor bobinado

    Directory of Open Access Journals (Sweden)

    André L.L.F. Murari

    2016-01-01

    Full Text Available Resumen: Este artículo reúne las informaciones básicas del control de generadores de inducción con rotor bobinado (GIRB para generación eólica, teniendo como objetivo direccionar al nuevo investigador en sus primeros pasos, tornándolo apto al desarrollo de la tecnología sea por medio de modificaciones o por adición de técnicas de accionamiento y control. El estator del GIRB está conectado directamente a la red eléctrica y su rotor a través de un duplo convertidor llamado back-to-back. En este sentido, este artículo presenta una propuesta para el diseño de las ganancias de los controladores proporcional-integral (PI utilizados en el control vectorial de potencias para el convertidor del lado del rotor del GIRB con el uso de la técnica de compensación por polos. También son presentadas las mallas de control de corriente del convertidor conectado a la red eléctrica, el diseño de la capacitancia de enlace de corriente continua y de la inductancia del filtro de armónicos. Los resultados de la simulación son presentados para validar la propuesta. Abstract: This article presents the basic information about the control of induction generators with wound rotor for wind generation. Its aim is to assist new researchers in their first steps, making them suitable for the development of technology either through modifications or by adding techniques of driving and control. The GIRB's stator is connected directly to the power grid and its rotor via a bi-directional converter called back-to-back. This way, this article presents a proposal for the design of the gains of the proportional-integral controllers (PI used in vector control of powers for the GIRB's rotor-side converter using the poles compensation technique. It also shows the current control loops of the converter connected to the power grid, the specification of the capacitance of the direct current link and the inductance of the harmonic filter. Simulation results are presented

  5. The effect of one session of supragingival plaque control on clinical and biochemical parameters of chronic periodontitis Efeito de uma única sessão de controle de placa supragengival nos parâmetros clínicos e bioquímicos da periodontite crônica

    Directory of Open Access Journals (Sweden)

    Érica Del Peloso Ribeiro

    2005-09-01

    Full Text Available Supragingival plaque control is a requisite for the success of any periodontal procedure. However, little is know about the effect of this procedure alone on periodontitis. The aim of this study was to determine the effect of supragingival plaque control on clinical and biochemical parameters of chronic periodontitis. Twenty-five subjects exhibiting at least 4 pockets > 5mm, non-smokers and with no relevant systemic diseases, were selected for the study. The clinical and biochemical assessments were done before and 21 days after removal of plaque retentive factors, extraction of affected teeth and instruction in oral hygiene. The statistical analysis was done with the Student paired t-test (pO objetivo deste estudo foi avaliar o efeito do controle de placa supragengival sobre os parâmetros clínicos e bioquímicos da periodontite crônica. Foram selecionados 25 pacientes apresentando pelo menos 4 sítios com profundidade de sondagem > 5 mm, não fumantes e sem alterações sistêmicas relevantes. A avaliação clínica e bioquímica foi feita antes e 21 dias após a remoção dos fatores retentivos de placa, exodontia dos dentes condenados e instrução de higiene bucal. A análise estatística foi feita através do teste t de Student pareado (p<0,05 e demonstrou redução da porcentagem de sítios com sangramento à sondagem de 42,72 ± 15,83 para 35,87 ± 13,30 (p=0,002. Redução na profundidade de sondagem foi observada nos dentes anteriores (média inicial/final: 2,88 mm/2,78 mm; p=0,01 e faces interproximais (média inicial/final: 3,80 mm/3,65 mm; p=0,001. Houve aumento de 66,81% para 68,65% (p=0,03 no número de sítios com profundidade de sondagem de 1 a 3 mm e redução de 26,21% para 24,17% (p=0,04 nos de 4 a 6 mm. O valor do BAPNA apresentou redução de 51,44 ± 20,78 para 38,64 ± 12,34 (p=0,04. Baseado nesses achados pôde-se concluir que o controle de placa supragengival tem efeitos benéficos, principalmente relacionados à redu

  6. Study of the Plugging of Oil Well Sand Control Area in a Polymer Flooding Region Étude du colmatage aux abords des puits d’injection dans un réservoir d’hydrocarbure produit par balayage au polymère

    Directory of Open Access Journals (Sweden)

    Liu Dong

    2012-05-01

    Full Text Available The plugging of the oil well sand control area in a polymer flooding region was studied and the plugging substances were analyzed through UV-Vis spectrophotometer analysis, plasma emission spectrometry analysis, laser particle size analysis, X-Ray Diffractometer (XRD analysis, microscopic observation, chromatograph-mass spectrometer, etc. It is inferred that the main reason for the plugging of the sand control area was the adsorption, gathering and bridging of PAM on the surface of the sand. The migration of the mineral fines from the stratum and the adsorption of the crude oil ingredients on the surface of the fines also result in plugging. An experimental study on the polymer degradation was performed and two types of plug removal agents, potassium persulfate and sodium thiosulfate, were selected and tested. It showed that potassium persulfate and sodium thiosulfate could degrade the plugging substances and recover core permeability effectively. Moreover, field application tests were conducted in Gudao oil field which showed the restoration of the performance of various wells. It also indicated that the injection pressure obviously decreased and liquid production per day increased greatly after application of the plug removal agents in the sand control area. Le colmatage des zones de puits où un contrôle de venues de sable est réalisé par injection de polymère a été étudié et les substances à l’origine du colmatage ont été analysées par spectrophotométrie UV-Visible, spectrométrie à émission de plasma, analyse de taille de particules par diffraction laser, diffraction X (DRX, observation microscopique, spectrométrie de masse, etc. Nous avons conclu que la raison principale du colmatage de la zone de contrôle des venues de sable était l’adsorption, l’accumulation et le pontage du polyacrylamide (PAM à la surface du sable. La migration des fines du milieu poreux et l’adsorption de composés du brut à la surface des

  7. Childhood Pars Planitis; Clinical Features and Outcomes

    Directory of Open Access Journals (Sweden)

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  8. Increased Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR Levels in Plasma of Suicide Attempters.

    Directory of Open Access Journals (Sweden)

    Filip Ventorp

    Full Text Available The soluble form of the urokinase receptor, suPAR, has been suggested as a novel biomarker of low-grade inflammation. Activation of the immune system has been proposed to contribute to the development of depression and suicidal behavior. In order to identify depressed and suicidal individuals who could benefit from an anti-inflammatory treatment, a reliable biomarker of low-grade inflammation is vital. This study evaluates plasma suPAR levels as a biomarker of low-grade inflammation in patients with major depressive disorder and in patients who recently attempted suicide. The plasma suPAR and an established biomarker, C reactive protein (CRP of suicide attempters (n = 54, depressed patients (n = 19 and healthy controls (n = 19 was analyzed with enzyme-linked immunosorbent assays. The biomarker attributes of sensitivity and sensibility were evaluated using ROC curve analysis. Both the depressed patients and suicide attempters had increased plasma suPAR. The levels of suPAR discriminated better between controls and suicide attempters than did CRP. In the future, plasma suPAR might be a superior prognosticator regarding outcome of treatment applying conventional antidepressants in conjunction with anti-inflammatory drugs.

  9. Study of a class of photovoltaic systems using a bond graph approach. Modeling, analysis and control; Etude d'une classe de systemes photovoltaiques par une approche bond graph. Modelisation, analyse et commande

    Energy Technology Data Exchange (ETDEWEB)

    Andoulsi, R.

    2001-12-01

    We present in this thesis a study of a class of photovoltaic system by a bond graph approach. This study concerns the modelling, the analysis and the control of some configurations including PV generator, DC/DC converters and DC motor-pumps. The modelling of the different elements of a photovoltaic system is an indispensable stage that must precede all application of sizing, identification or simulation. However, theses PV systems are of hybrid type and their modelling is complex. It is why we use a unified modelling approach based on the bond graph technique. This methodology is completely systematic and has a sufficient flexibility for allowing the introduction of different components in the system. In the first chapter, we recall the principle of functioning of a photovoltaic generator and we treat mainly the MPPT (Maximum Power Point Tracking) working. In the second chapter, we elaborate bond graph models of various photovoltaic system configurations. For the PV source, we elaborate, in a first stage, a complete model taking into account the various physical phenomena influencing the quality of the PV source. In a second stage, we deduce a reduced bond graph model more easy to use for analysis and control purposes. For the DC/DC converters, we recall the bond graph modelling of switching elements and the average bond graph of the DC/DC converters developed in the literature. Thus, we deduce the bond graphs models of the various DC/DC converters to be used. The third chapter presents a dynamic study of some configurations stability in linear procedure. In the fourth chapter, we study the feasibility of non linear controllers by input/output linearization for some configurations of PV systems. In this study, we use the concept of inverse bond graph to determine, by a bond graph approach, the expression of the control input and the nature of the stability of the internal dynamics (dynamics of zeros). The fifth chapter is dedicated for the presentation of some

  10. Accouchement par forceps: indications et pronostic materno-foetal ...

    African Journals Online (AJOL)

    L'accouchement par voie basse, peut être parfois compromis par des facteurs maternels, foetaux ou materno-foetaux nécessitant des moyens thérapeutiques comme le forceps pour achever l'accouchement par voie naturelle. Le forceps, une méthode qui n'est pas sans risque pour la mère et le nouveau-né. Nous avons ...

  11. Control del parásito Varroa destructor (Acari: Varroidae en colmenas de la abeja Apis mellifera (Hymenoptera: Apidae mediante la aplicación de la técnica de entrampado

    Directory of Open Access Journals (Sweden)

    Natalia DAMIANI

    2006-01-01

    Full Text Available La parasitosis causada por el ácaro Varroa destructor (Anderson & Trueman es, actualmente considerada el mayor escollo para el desarrollo de la apicultura. El objetivo del presente trabajo fue evaluar la técnica del entrampamiento de ácaros en panales de cría, como posible método de control de la parasitosis. El trabajo se llevó a cabo en Coronel Vidal, provincia de Buenos Aires. Se trabajó sobre colmenas tipo Langstroth del híbrido regional de Apis mellifera (Linneaus. En cada colmena experimental se procedió a confinar a la reina en panales trampa específicos, con el fin de poder controlar la oviposición. Estos panales, luego de ser operculados por las obreras, fueron llevados al laboratorio donde se desoperculó cada una de las celdas de cría, y se contabilizó el número de ácaros presentes. Esta técnica se aplicó variando el número de panales trampa (1-3 colocados, tanto para los constituidos por celdas de cría de obreras como de zánganos. También, se evaluó el impacto de la aplicación de esta técnica sobre el desarrollo de las colonias, mediante la medición de su productividad. Los resultados indican, que la técnica empleada sólo es efectiva, cuando se aplican tres panales de cría de zánganos de manera consecutiva alcanzando una efectividad máxima de 84%. Cuando se aplican tres panales de obreras, la técnica mostró niveles de efectividad muy inferiores (14%. En las colonias sobre las que se aplicó esta técnica, la productividad de miel se redujo significativamente, comparada con las colonias control. Esta técnica resulta ideal para ser combinada con otros mecanismos de control, disminuyendo la aplicación de sustancias químicas que puedan contaminar la miel, y la generación de resistencia por parte del ácaro frente a los principios activos utilizados para su control.

  12. The rate of endophthalmitis after pars plana vitrectomy and its risk factors.

    Science.gov (United States)

    Tabatabaei, Seyed Ali; Soleimani, Mohammad; Vakili, Hadi; Naderan, Morteza; Lashay, Alireza; Faghihi, Houshang; Yaseri, Mehdi

    2018-05-11

    To study the incidence of endophthalmitis after pars plana vitrectomy, its causative organisms, and visual acuity outcomes. In this retrospective, comparative study, the medical records of patients with acute-onset postoperative endophthalmitis after pars plana vitrectomy at Farabi Eye Hospital, Tehran, Iran, during a 12-year period between January 2004 and November 2015 were reviewed. To compare the endophthalmitis patients with other cases who underwent pars plana vitrectomy at the same day and also the same operating room, a control group was developed by gathering the data from surgical records. In the present study, the incidence rate of pos- vitrectomy endophthalmitis was 0.04% (16/39783). The organisms identified in aqueous or vitreous cultures (culture positive 44%) included Streptococcus pneumoniae (two patients, 12.5%), Pseudomonas aeruginosa (two patients, 12.5%), fungi (two patients, 12.5%), and Streptococcus viridans (one patient, 6.25%). Visual acuity after treatment for endophthalmitis ranged from light perception (7 eyes) to hand motion (1 eye), and evisceration was performed in 8 eyes (50%). When comparing the cases (patients developing endophthalmitis) and controls (patients with no complications operated in the same day and place of operation with the case group), only not using tamponade showed a statistically significant relation with the occurrence of endophthalmitis (p = 0.034). Our results indicated low incidence of endophthalmitis after pars plana vitrectomy comparable to previous studies which resulted in poor visual acuity. It seems that not using tamponade might increase the risk of endophthalmitis among these patients.

  13. Checking the sealing of fuel elements by helium sweating - case of the reactors G2 (1960); Controle de l'etancheite des elements combustibles par ressuage d'helium - cas du reacteur G2 (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Blanc, B; D' Orival, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Choumoff, S [Compagnie Francaise Thomson-Houston, 75 - Paris (France)

    1960-07-01

    The G2 slug is a welded, hermetically sealed unit; the seal is checked by placing the fuel element in a helium atmosphere under pressure, then measuring the quantity of helium it releases in a vessel under vacuum. The theoretical aspect and the conditions of industrial application are reviewed, and the installations described. (author) [French] La cartouche G2 se presente comme un ensemble soude, hermetique; le controle d'etancheite s'effectue en immergeant l'element combustible dans une atmosphere d'helium sous pression puis en mesurant la quantite d'helium qu'il restitue dans une enceinte sous vide. L'aspect theorique et les conditions d'exploitation industrielle sont evoques et les installations decrites. (auteur)

  14. Fast Plasma from a Coaxial Gun; Plasma Rapide Produit par un Canon Coaxial; Bystraya plazma iz koaksial'nogo inzhektora; Produccion de Plasma Rapido Mediante un Inyector Coaxial

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, J.; Henins, I. [Los Alamos Scientific Laboratory, Los Alamos, NM (United States)

    1966-04-15

    volume around the jet. Fast plasma is emitted in a narrow conical distribution with an open centre. The high voltage which accelerates the fast deuterohs also accelerates wall material ions if the fast plasma bombards a glass wall and evaporates it. (author) [French] Le canon coaxial utilise dans cette experience est une source de deux plasmas differents produits par des mecanismes separes. Un plasma de deuterium abondant et lent ( Tilde-Operator 10{sup 7} cm/s) est produit directement par l'interaction du type j xli ou j est le courant de plasma radial et if le champ magnetique produit par le courant d'alimentation le long de l'electrode centrale. La perturbation de courant se deplace, a travers le gaz injecte, vers l'ouverture du canon, a une vitesse d'environ 2,5 * 10{sup 7} cm/s et emmagasine de l'energie a l'arriere sous forme de champ magnetique et d'energie cinetique de plasma. Par son energie emmagasinee, le canon fonctionne comme un generateur electrique de basse impedence et de grande puissance de maniere a lancer dans le vide au-dela de l'ouverture du canon un jet de courant qui est la source de plasma rapide ( Tilde-Operator 5 x 10{sup 17} deuterons, Tilde-Operator 10{sup 8} cm/s). Le jet de courant ainsi que le plasma qu'il produit font l'objet des experiences decrites dans ce memoire. Le mecanisme de l'acceleration est complique et n'est pas parfaitement connu, mais beaucoup d'enseignements ont ete tires d'un grand nombre d'experiences dans lesquelles ont ete utilises les diagnostics suivants: boucles de captage diamagnetique externes, boucles Rogowsky sous vide, sondes electriques, electrode de captage capacitive externe, analyse de la deflection magnetique et electrostatique de particules, spectroscopic, photographie de la lumiere emise par les cibles, mesure de temps de vol avec ou sans champ de guidage, neutrons emis par le volume,du plasma par suite de la reaction d-d, etc. Il en resulte que le mecanisme d'acceleration consiste en un processus magneto

  15. Bancroftian filariasis in Belém, Pará State: possibilities for eradication by introducing modern methods of control for Culex quinquefasciatus A filariose bancroftiana em Belém, Pará: possibilidades atuais de erradicação mediante a integração à campanha de novos métodos de controle da população de Culex quinquefasciatus

    Directory of Open Access Journals (Sweden)

    Habib Fraiha Neto

    1993-12-01

    Full Text Available For the past four decades, Belém has been considered to be the largest focus of Bancroftian filariasis in the Amazon region and one of the most important ones in Brazil. In 1952, practically one-fifth of the population was infected and it was estimated that there were 2,500 cases of Bancroftian elephantiasis. The major factor considered to be responsible for this situation was the high density of the main vector species: it was calculated that in April 1943 there was a mean of 67 infected mosquitoes per house. A control campaign was initiated in 1952, involving treatment of patients with diethylcarbamazine, as well as control of the vector. In 1956, vector control was discontinued because of a lack of efficient insecticides and financial limitations. Even so, the campaign was very successful and the incidence was reduced from 19.9% to 0.03%. Total eradication could be achieved if new methods of vector control were introduced, such as the use of Reiter's expanded polystyrene balls in cesspits and pit latrines, biological control using pathogenic bacteria, and improvement of basic sanitation.Há mais de quatro décadas Belém é considerada o maior foco de bancroftose da região amazônica e um dos mais importantes do Brasil. Em 1952, praticamente um quinto de sua população apresentava microfilárias no sangue, estimando-se em 2.500 os casos de elefantíase. O fator considerado o maior condicionante de tão extraordinária freqüência era a alta densidade local do principal vetor, Culex quinquefasciatus. Em abril de 1943 calculava-se uma média de 67 fêmeas da espécie infectadas por domicílio. Uma campanha de controle foi deflagrada em 1952, incluindo busca ativa e tratamento dos casos com dietilcarbamazina, além medidas de combate ao vetor. Estas foram abandonadas em 1956, por força da ineficácia ou do alto custo dos inseticidas. Ainda assim, a campanha foi muito bem sucedida, reduzindo a incidência de 19,9 para 0,03%. Hoje, a erradica

  16. Non-Destructive Examination of the Heat-Affected Zone of Welded Zr-Nb Alloy; Controle Non Destructif de la Zone d'Un Alliage Zr-Nb Affectee par la Chaleur Lors du Soudage; Nedestruktivnoe ispytanie zony svarnogo shva iz tsirkonij-niobij splava, kotoryj podverzhen teplovomu vliyaniyu; Examen No Destructivo de la Zona de Soldadura Afectada por el Calor en las Aleaciones de Circonio y Niobio

    Energy Technology Data Exchange (ETDEWEB)

    Hanstock, R. F.; Walker, D. C.B. [U.K.A.E.A. Reactor Materials Laboratory, Culcheth (United Kingdom)

    1965-10-15

    chaleur qui sont susceptibles de corrosion pouvaient etre decelees par controle non destructif, en mesurant le potentiel thermoelectrique aux bornes d'une sonde metallique chauffee, en contact avec des parties determinees de la soudure et le metal adjacent. La sonde thermoelectrique est similaire a celle mise au point par l'Association britannique de recherches sur les metaux non ferreux en vue de mesurer l'epaisseur des revetements de plaques de metal; un instrument en vente sur le marche et muni de ce type de sonde peut etre utilise, apres une legere modification, pour le controle des soudures dans les alliages Zr-Nb. Le memoire donne un exemple de la variation de la reponse de la sonde dans des zones affectees par la chaleur lors du sondage; les resultats sont compares a ceux d'un examen en autoclave. (author) [Spanish] Las aleaciones de circonio con 2 Vulgar-Fraction-One-Half % de niobio ofrecen, gracias al tratamiento termico, la ventaja de resistir la presion en los reactores moderados por agua. Por otra parte, ese tratamiento afecta considerablemente a la resistencia a la corrosion en las condiciones de funcionamiento del reactor, siendo de seuealar que pueden surgir puntos especialmente vulnerables en las zonas de las soldaduras sometidas al calor. Las zonas susceptibles de corrosion pueden localizarse mediante tratamiento en autoclase, pero no es conveniente aplicarlo cuando extensos circuitos de presion se arman mediante soldadura. Se ha comprobado que las zonas afectadas por el calor que son vulnerables a la corrosion pueden localizarse por metodos no destructivos consistentes en medir el potencial termoelectrico entre la punta de una sonda metalica caliente en contacto con determinadas partes de la soldadura y el del metal adyacente. La sonda es analoga a la que ha diseueado la British-ferrous Metals Research Association para medir el espesor del chapado de sustratos metalicos. Los instrumentos comerciales equipados con ese tipo de sonda sirven con una

  17. PAR1 activation affects the neurotrophic properties of Schwann cells.

    Science.gov (United States)

    Pompili, Elena; Fabrizi, Cinzia; Somma, Francesca; Correani, Virginia; Maras, Bruno; Schininà, Maria Eugenia; Ciraci, Viviana; Artico, Marco; Fornai, Francesco; Fumagalli, Lorenzo

    2017-03-01

    Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier. Schwann cells are the principal population of glial cells of the peripheral nervous system which myelinate axons playing an important role during axonal regeneration and remyelination. The present study was undertaken in order to determine if the activation of PAR1 affects the neurotrophic properties of Schwann cells. Our results suggest that the stimulation of PAR1 could potentiate the Schwann cell ability to favour nerve regeneration. In fact, the conditioned medium obtained from Schwann cell cultures challenged with a specific PAR1 activating peptide (PAR1 AP) displays increased neuroprotective and neurotrophic properties with respect to the culture medium from untreated Schwann cells. The proteomic analysis of secreted proteins in untreated and PAR1 AP-treated Schwann cells allowed the identification of factors differentially expressed in the two samples. Some of them (such as macrophage migration inhibitory factor, matrix metalloproteinase-2, decorin, syndecan 4, complement C1r subcomponent, angiogenic factor with G patch and FHA domains 1) appear to be transcriptionally regulated after PAR1 AP treatment as shown by RT-PCR. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Taare Zameen Par and dyslexic savants.

    Science.gov (United States)

    Chakravarty, Ambar

    2009-04-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely 'disinhibits' the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  19. Soudage de bois feuillus par friction rotationnelle

    OpenAIRE

    Belleville, Benoît

    2012-01-01

    Les différentes colles utilisées actuellement par l’industrie du meuble au Canada nécessitent des temps de polymérisation constituant un goulot dans la production des meubles et limitant l’atteinte de la production unitaire. Ces adhésifs synthétiques généralement issus de la pétrochimie nécessitent énormément d’énergie lors de leur confection. L’utilisation de connecteurs métalliques ou plastiques, quant à elle, limite les phases de découpage et sablage subséquentes. La présence d’adhésifs et...

  20. La projection par plasma : une revue

    Science.gov (United States)

    Fauchais, P.; Grimaud, A.; Vardelle, A.; Vardelle, M.

    The quality of a plasma sprayed coating depends on numerous parameters that start to be understood due to the recent progresses in modelling and measurement techniques for plasma jets, momentum, heat and mass transfers between plasma and particles, the way the particules splat and cool down upon impact on the substrate or the previously deposited layers. In this paper, first are recalled the used measurement techniques and their limitations both for plasma jets and particles in flight. Then are underlined the importance of the different phenomena envolved in the transfers between plasma and particles such as steep temperature and chemical species density gradients around the particles, heat propagation phenomenon especially for ceramic particles and the connected evaporation effect, rarefaction effect which occurs even at atmospheric pressure. The problems related to the size and injection velocity distributions which determine the trajectory distributions and the heat treatments undergone by the particles are treated. The study of plasma generation shows on one hand for d.c. arc plasma torches the drastic influence on the plasma jets lengths and diameters of the gas injection chamber design, the gas nature, the design of the arc chamber and nozzle, the surrounding atmosphere (especially air pumping which cools down very fast the plasma) and on the other hand for RF plasmas the importance of the particle injection design to avoid the coupling between the RF discharge and the carrier gas with the particles. All these points are illustrated with examples of coatings of alumina, zirconia carbide and nickel particles. The way the particles splat is then studied with the chemical reactions in flight, the fast quenching of the particles and the resulting cristalline structures, the coating adhesion and also the residual stesses and their control through that of the temperature gradients into the coatings during spraying. At last a few actual and potential applications

  1. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

    Science.gov (United States)

    Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

    2011-01-01

    This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891

  2. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  3. Incorporating GOES Satellite Photosynthetically Active Radiation (PAR) Retrievals to Improve Biogenic Emission Estimates in Texas

    Science.gov (United States)

    Zhang, Rui; White, Andrew T.; Pour Biazar, Arastoo; McNider, Richard T.; Cohan, Daniel S.

    2018-01-01

    This study examines the influence of insolation and cloud retrieval products from the Geostationary Operational Environmental Satellite (GOES) system on biogenic emission estimates and ozone simulations in Texas. Compared to surface pyranometer observations, satellite-retrieved insolation and photosynthetically active radiation (PAR) values tend to systematically correct the overestimation of downwelling shortwave radiation in the Weather Research and Forecasting (WRF) model. The correlation coefficient increases from 0.93 to 0.97, and the normalized mean error decreases from 36% to 21%. The isoprene and monoterpene emissions estimated by the Model of Emissions of Gases and Aerosols from Nature are on average 20% and 5% less, respectively, when PAR from the direct satellite retrieval is used rather than the control WRF run. The reduction in biogenic emission rates using satellite PAR reduced the predicted maximum daily 8 h ozone concentration by up to 5.3 ppbV over the Dallas-Fort Worth (DFW) region on some days. However, episode average ozone response is less sensitive, with a 0.6 ppbV decrease near DFW and 0.3 ppbV increase over East Texas. The systematic overestimation of isoprene concentrations in a WRF control case is partially corrected by using satellite PAR, which observes more clouds than are simulated by WRF. Further, assimilation of GOES-derived cloud fields in WRF improved CAMx model performance for ground-level ozone over Texas. Additionally, it was found that using satellite PAR improved the model's ability to replicate the spatial pattern of satellite-derived formaldehyde columns and aircraft-observed vertical profiles of isoprene.

  4. The photothermal camera - a new non destructive inspection tool; La camera photothermique - une nouvelle methode de controle non destructif

    Energy Technology Data Exchange (ETDEWEB)

    Piriou, M. [AREVA NP Centre Technique SFE - Zone Industrielle et Portuaire Sud - BP13 - 71380 Saint Marcel (France)

    2007-07-01

    techniques classiques de controle de surface (ressuage, magnetoscopie, courants de Foucault) pour: - detecter sans aucun contact, des defauts sous ligaments ou debouchants de quelques microns d'ouverture, sur des pieces metalliques non preparees (oxydees, usinees, soudees), - fonctionner sur des surfaces aux geometries variees, sur des pieces chaudes, sur des materiaux isolants (dielectriques), sans etre affectee par les proprietes magnetiques de la piece a examiner. Cette methode a permis, entre autre, de controler in situ les soudures 'tube/plaque' d'un echangeur intermediaire du reacteur rapide Phenix, de prouver qu'elle est une alternative au ressuage pour le controle des soudures de l'enceinte a vide d'ITER, de detecter des fissures dans les soudures (ex: J-weld d'adaptateurs de couvercles) et de reveler la fissuration amorcee par faiencage thermique. Les particularites de cette methode innovante sont: - de fonctionner a distance de la piece a controler, jusqu'a 2 metres, - d'etre totalement telecommandee a la distance de 15 metres (voire beaucoup plus par lien Ethernet), - d'etre une methode 'propre' puisqu'elle ne genere aucun dechet. Ces particularites en font une methode alternative au ressuage, afin de garantir la protection des operateurs et de l'environnement. (auteur)

  5. Concerning the dynamic instability of actin homolog ParM

    International Nuclear Information System (INIS)

    Popp, David; Yamamoto, Akihiro; Iwasa, Mitsusada; Narita, Akihiro; Maeda, Kayo; Maeda, Yuichiro

    2007-01-01

    Using in vitro TIRF- and electron-microscopy, we reinvestigated the dynamics of native ParM, a prokaryotic DNA segregation protein and actin homolog. In contrast to a previous study, which used a cysteine ParM mutant, we find that the polymerization process of wild type ATP-ParM filaments consists of a polymerization phase and a subsequent steady state phase, which is dynamically unstable, like that of microtubules. We find that the apparent bidirectional polymerization of ParM, is not due to the intrinsic nature of this filament, but results from ParM forming randomly oriented bundles in the presence of crowding agents. Our results imply, that in the bacterium, ParM filaments spontaneously form bipolar bundles. Due to their intrinsic dynamic instability, ParM bundles can efficiently 'search' the cytoplasmic lumen for DNA, bind it equally well at the bipolar ends and segregate it approximately symmetrically, by the insertion of ParM subunits at either end

  6. The protein kinase SIK downregulates the polarity protein Par3

    DEFF Research Database (Denmark)

    Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta

    2018-01-01

    on Par3. Functionally, this mechanism impacts on tight junction downregulation. Furthermore, SIK contributes to the loss of epithelial polarity and examination of advanced and invasive human cancers of diverse origin displayed high levels of SIK expression and a corresponding low expression of Par3...

  7. Nouvelle structure de capteur à courants de Foucault et algorithme associé pour la mesure des propriétés électrique et magnétique d'un métal

    Science.gov (United States)

    Lê, Minh-Quang; Placko, Dominique

    1995-06-01

    This paper describes a new structure for eddy-current transducers which improves sensitivity while maintaining high lateral resolution. We have developed an analytical model to allow a model-based inversion from transducers signals to estimate thick and homogeneous plates electrical conductivity, magnetic permeability and/or lift-off. The inversion procedure is described and shows the possibility of a precise simultaneous estimation of the three parameters. Experiments were conducted with magnetic and non magnetic metals. Cet article décrit une nouvelle structure de capteur à courants de Foucault qui permet d'améliorer la sensibilité du capteur tout en conservant sa résolution latérale. Nous avons développé un modèle analytique de ce capteur qui peut être inversé pour estimer la conductivité électrique, la perméabilité magnétique d'une cible homogène et/ou la distance capteur-cible. La procédure d'inversion a été décrite et montre une possibilité d'estimer ces trois paramètres avec précision. L'expérience a été effectuée sur des métaux magnétiques et amagnétiques.

  8. Project Plan 7930 Cell G PaR Remote Handling System Replacement

    International Nuclear Information System (INIS)

    Kinney, Kathryn A.

    2009-01-01

    For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ( 252 Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for 252 Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for 252 Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully functioning and

  9. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  10. Quality Selection of Zircaloy-2 Canning Tubes by Ultrasonic Testing on Small Defects; Controle de la Qualite des Gaines en Zircaloy-2: Detection de Petits Defauts par les Ultrasons; Achestvennyjotb ortrub chatykh obolochek iz tsirkalloya-2 putem vyyavleniya nebol'shikh defektov s pomoshch'yu ul'trazvuka; Control de Calidad de los Revestimientos de Zircaloy-2 por Localizacion Ultrasonica de Pequenos Defectos

    Energy Technology Data Exchange (ETDEWEB)

    Van Der Linde, A. [Reactor Centrum Nederland, Petten (Netherlands); Deraad, J. A. [Roentgen Technische Dienst N.V., Rotterdam (Netherlands)

    1965-09-15

    epaisseur de 0,90 mm et une longueur de 1500 mm, destinees a des essais en pile (dans une boucle a eau sous pression , a la temperature de 330 Degree-Sign C) en vue de leur utilisation pour le gainage de barreaux de combustible, ont ete soumises a un controle au moyen d'ultrasons pour detecter leurs defauts et evaluer leur qualite. Les gaines soumises aux essais avaient ete livrees par des fabricants des Etats-Unis, du Royaume-Uni et des pays scandinaves. D'apres les specifications, toutes les gaines devaient etre exemptes de failles ayant plus de 500 a 1000pm de longueur et plus de 50 a 25 {mu}m de profondeur, mais les fabricants n'avaient pas accepte de repondre pleinement a ces exigences. Ils pouvaient simplement garantir qu'il n'y aurait pas de failles ayant plus de 1.000 pm de longueur et plus de 50 {mu}m de profondeur. Comme seulement deux des 93 gaines controlees presentaient des failles ayant plus de 50 {mu}m de profondeur, on a decide de faire un controle plus severe pour detecter des failles de 10 a 50 {mu}m de profondeur. Pour detecter et enregistrer des defauts aussi minimes, on a utilise un dispositif semi-automatique a impulsions ultrasonores, en meme temps que des conditionneurs et un enregistreur multicanal. L'appareil d'exploration etait regle de telle facon que des defauts de meme taille etaient indiques avec la meme amplitude, qu'ils soient interieurs ou exterieurs. L'etalonnage du meteriel a ete fait au moyen de defauts artificiels. Les defauts longitudinaux ont ete detectes au moyen d'un emetteur-recepteur distinct, a faisceau focalise. Les defauts transversaux ont ete detectes par une sonde unique faisant office de traducteur. Pour obtenir la sensibilite voulue, les essais ont ete effectues en immersion, avec une frequence de 4 MHz, les tubes tournant a 120 t/min. Le memoire decrit le dispositif mecanique, l'ensemble des operations et les difficultes rencontrees. On a constate que, sur 93 gaines controlees, 21 presentaient des defauts transversaux

  11. Decontamination of lead by fusion (1962); Decontamination du plomb par fusion (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Boutot, P; Giachetto, L; Capitaine, A [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1962-07-01

    Various attempts to decontaminate using mechanical and chemical methods having given questionable results, a fusion method has been developed. The apparatus consists of a propane-heated oven fitted with a steel crucible of 1 400 kg capacity, with two ventilation systems, and with a vacuum gauge for preventing the diffusion of toxic gases. There are three operational controls : 1. On the samples taken before during and after the operation, 2. On the plugs taken from the ingots, 3. On the ingot itself. The continuous sanitary control is done by a radioactive aerosol recorder and by periodic sampling. This decontamination process will be improved, especially as far as the productivity and the safety precautions are concerned. (authors) [French] Divers essais de decontamination par voies mecaniques et chimiques ayant donne des resultats discutables, un procede par fusion a ete mis au point. L'appareil se compose d'un four, chauffe au propane, muni d'un creuset en acier d'une capacite de 1 400 kg, de deux systemes de ventilation et d'un deprimometre afin d'eviter la diffusion de vapeurs nocives. Trois controles d'activite sont effectues: 1. sur des echantillons preleves avant, pendant et apres l'operation, 2. sur des carottages realises sur les lingots, 3. sur le lingot lui-meme. Le controle sanitaire permanent est assure par un enregistreur d'aerosols radioactifs et par des prelevements periodiques. Ce procede de decontamination doit encore etre ameliore, principalement en ce qui concerne la productivite et la securite. (auteurs)

  12. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....

  13. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  14. Protease-activated receptor (PAR2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

    Directory of Open Access Journals (Sweden)

    Lisa G van den Hengel

    Full Text Available AIMS: In collateral development (i.e. arteriogenesis, mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. METHODS AND RESULTS: PAR1-deficient (PAR1-/-, PAR2-deficient (PAR2-/- and wild-type (WT mice underwent femoral artery ligation. Laser Doppler measurements revealed reduced post-ischemic blood flow recovery in PAR2-/- hind limbs when compared to WT, while PAR1-/- mice were not affected. Upon ischemia, reduced numbers of smooth muscle actin (SMA-positive collaterals and CD31-positive capillaries were found in PAR2-/- mice when compared to WT mice, whereas these parameters in PAR1-/- mice did not differ from WT mice. The pool of circulating repair-associated (Ly6C-low monocytes and the number of repair-associated (CD206-positive macrophages surrounding collaterals in the hind limbs were increased in WT and PAR1-/- mice, but unaffected in PAR2-/- mice. The number of repair-associated macrophages in PAR2-/- hind limbs correlated with CD11b- and CD115-expression on the circulating monocytes in these animals, suggesting that monocyte extravasation and M-CSF-dependent differentiation into repair-associated cells are hampered. CONCLUSION: PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD patients.

  15. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

    Science.gov (United States)

    Cunningham, Margaret R; McIntosh, Kathryn A; Pediani, John D; Robben, Joris; Cooke, Alexandra E; Nilsson, Mary; Gould, Gwyn W; Mundell, Stuart; Milligan, Graeme; Plevin, Robin

    2012-05-11

    Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh supply of receptor is required to be mobilized to the cell surface for responsiveness to agonist to be sustained. Unlike other PAR subtypes, the mechanisms regulating receptor trafficking of PAR(4) remain unknown. Here, we report novel features of the intracellular trafficking of PAR(4) to the plasma membrane. PAR(4) was poorly expressed at the plasma membrane and largely retained in the endoplasmic reticulum (ER) in a complex with the COPI protein subunit β-COP1. Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR → A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4). Interestingly, co-expression with PAR(2) facilitated plasma membrane delivery of PAR(4), an effect produced through disruption of β-COP1 binding and facilitation of interaction with the chaperone protein 14-3-3ζ. Intermolecular FRET studies confirmed heterodimerization between PAR(2) and PAR(4). PAR(2) also enhanced glycosylation of PAR(4) and activation of PAR(4) signaling. Our results identify a novel regulatory role for PAR(2) in the anterograde traffic of PAR(4). PAR(2) was shown to both facilitate and abrogate protein interactions with PAR(4), impacting upon receptor localization and cell signal transduction. This work is likely to impact markedly upon the understanding of the receptor pharmacology of PAR(4) in normal physiology and disease.

  16. Purification by high vacuum fusion and progressive solidification of uranium from electrolytic origin; Purification par fusion sous vide eleve et solidification progressive d'uranium d'origine electrolytique

    Energy Technology Data Exchange (ETDEWEB)

    Poeydomenge, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-01-15

    grain observed, so-called secondary recrystallisation. in appendix, the method for measuring the electrical resistance by induction (with direct current)is studied from the fundamental and experimental point of view. The author applied it to the particular case of uranium for measuring the low-temperature resistance of the bars from the same which solidified first to the least pure ended the ingot. (author) [French] Dans le cadre de recherches generales sur la purification de l'uranium par fusion de zone, on a entrepris de determiner le degre de purification que l'on pourrait atteindre par une simple solidification progressive a vitesse et direction soigneusement controlees d'un uranium de purete nucleaire courante. Cet uranium de purete intermediaire fournirait un materiau de depart approprie au mode de purification ultime qu'est la fusion a zone verticale, dite ''flottante''. Dans ce but, des lingots d'uranium d'origine electrolytique ont ete refondus sous vide (2 a 5 x 10{sup -6} mm) dans une longue nacelle en UO{sub 2} apres une monte lente en temperature pour eliminer le maximum de gaz et d'impuretes volatiles. Ce degazage et cette volatilisation d'impuretes sont completes par maintien prolonge a haute temperature du bais liquide. Celui-ci est ensuite solidifie d'une extremite a l'autre de la nacelle par deplacement a vitesse lente et constante du front de solidification de facon a obtenir une repartition des impuretes selon les lois etablies par PFANN. Differentes methodes experimentales ont permis de montrer que le metal solidifie en premier lieu est nettement plus pur que celui de la partie solidifie a l'extremite opposee du lingot. Le degre de purification du metal en tete du lingot a ete apprecie, soit quantitativement par mesure du rapport des resistivites electriques a la temperature ambiante et a celle de l'azote liquide, soit qualitativement par l'examen de la structure micrographique et par l'etude de la recristallisation du metal. D'une part, le metal

  17. Could soluble urokinase plasminogen receptor (suPAR) be used as a diagnostic biomarker for ventilator-associated pneumonia?

    Science.gov (United States)

    Sunnetcioglu, Aysel; Sunnetcioglu, Mahmut; Adıyaman, Fırat; Binici, Irfan; Soyoral, Lokman

    2017-11-01

    Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that is increasingly used for evaluation of systemic inflammation. This study was performed to investigate whether suPAR may possess a diagnostic value in patients with ventilator-associated pneumonia (VAP). This clinical study was performed in the anesthesia intensive care units (ICUs) of our university. In addition to descriptive data, WBC, serum levels of C-reactive protein (CRP) and suPAR prior to and after development of VAP were noted and compared in 31 patients (22 men, 9 women) diagnosed with VAP (Study Group) and 19 patients without VAP (Control Group) in ICU (14 men, 5 women). The suPAR (P = 0.023), CRP (P = 0.037), WBCs (P = 0.024) in patients with VAP were significantly higher than patients without VAP. There was no remarkable difference in terms of WBCs (P = 0.052) and suPAR levels (P = 0.616) between groups on the first day of connection to mechanical ventilator. The suPAR and CRP levels in patients with VAP were significantly higher than prior to development of VAP (P = 0.001 for both). Area under curve value after diagnosis of pneumonia was found 0.248 (P = 0.002). To conclude, our results suggest that suPAR can be a useful diagnostic biomarker in patients with VAP. However, clinical trials on larger series are warranted to explore the clinical significance more accurately. © 2016 John Wiley & Sons Ltd.

  18. Solar water heating at Ikea's Montreal store; Chauffage solaire de l'eau courante au magasin Ikea de Montreal

    Energy Technology Data Exchange (ETDEWEB)

    Lagana, A.; Sonmor, K. [Ecovision experts-conseils inc., Montreal, PQ (Canada)

    2010-01-01

    The Ikea store in Montreal has integrated an energy efficient solar water heater into its building infrastructure. In June 2010, 30 fixed solar panels were installed on the roof to recuperate energy from the sun for hot water use in the restaurant and store facilities. Prior to this installation, the store was using natural gas for water heating purposes. During a sunny summer day, the solar water heater can provide 100 percent of the hot water needs of the store, even though it was designed to provide only one-third of the heating requirements. The panels are made of copper and painted with black titanium paint. A solution of water and antifreeze circulates in the panels. Digital controls are used at the pumps to control the temperature. The Ikea store uses approximately 3,100 gallons of water per day. The panels provide more than 60 MWh of energy, and represent a savings of 8440 cubic metres of natural gas, and a savings of 19.7 tons of carbon dioxide. The panels cost $1,300 and the return on investment is estimated to be 15.6 years. 3 figs.

  19. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...

  20. Peptide-Based Optical uPAR Imaging for Surgery

    DEFF Research Database (Denmark)

    Juhl, Karina; Christensen, Anders; Persson, Morten

    2016-01-01

    Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical...... tumor resection. In the present study, a new uPAR-targeted fluorescent probe was developed and the in vivo applicability was evaluated in a human xenograft mouse model. Most human carcinomas express high level of uPAR in the tumor-stromal interface of invasive lesions and uPAR is therefore considered...... an ideal target for intra-operative imaging. Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. For in vivo testing, human glioblastoma xenograft...

  1. Contribution de la tomographie par coherence optique au diagnostic ...

    African Journals Online (AJOL)

    Contribution de la tomographie par coherence optique au diagnostic de la neuropathie optique toxique. C.O.A. Abouki, S Alamou, C.R.A. Assavedo, L Odoulami-Yehouessi, I Sounouvou, S Hounnou-Tchabi ...

  2. Étude économique des foyers domestiques par la technique d ...

    African Journals Online (AJOL)

    Les foyers font partie de la vie courante. Chaque ménage en utilise pour la cuisson de ses repas. Dans les pays en développement, la plupart des populations utilisent surtout des foyers à combustibles ligneux. Les effets négatifs sur l'environnement sont aujourd'hui bien connus : poches de désertification, érosion des sols, ...

  3. Improvement of heat transfer by the use of corrugated surfaces; Amelioration du transfert de chaleur par l'emploi de surfaces corruguees

    Energy Technology Data Exchange (ETDEWEB)

    Gargaud, J; Paumard, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    noyau corrugue chauffe electriquement a flux constant et un canal exterieur lisse. 2. des essais sur tubes corrugues interieurement, chauffes par une circulation d'eau exterieure et refroidis par un courant interne de CO{sub 2} sous pression. Le premier type d'essais necessite des sondages de vitesses et de temperatures dans le fluide afin d'obtenir un coefficient de frottement et un nombre de Margoulis caracteristiques de la surface corruguee. Par contre, ces coefficients sont fournis directement par le second type d'essais. Cette etude fait apparaitre le role et l'importance des divers parametres geometriques et aerodynamiques tels que la rugosite relative, le pas reduit (rapport du pas a la hauteur de corrugation) et le nombre de Reynolds. (auteurs)

  4. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Directory of Open Access Journals (Sweden)

    Flavien Pillet

    Full Text Available Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  5. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Science.gov (United States)

    Pillet, Flavien; Passot, Fanny Marie; Pasta, Franck; Anton Leberre, Véronique; Bouet, Jean-Yves

    2017-01-01

    Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi) mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  6. Prise en charge des intoxications par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Les signes cliniques étaient dominés par les douleurs (98%) suivies des hémorragies (73,80%) pour les morsures de serpent, la douleur pour les piqures de scorpion (100%) et les oedèmes pour les piqures d'abeilles (100%). Les cas de morsure de serpent ont été traités par le sérum antivenimeux polyvalent. Conclusion: ...

  7. Intoxication par la paraphényléne-diamine

    African Journals Online (AJOL)

    raoul

    9 mars 2011 ... remède contre la douleur par Averbukh [8], ou contre la constipation par Schemesh [9], mais l´utilisation à des fins autolytique reste toujours prédominante. Le tableau clinique de l´intoxication à ... une anurie ayant nécessité le recours à l´hémodialyse. Ce taux de survenue d´IRA anurique est relativement ...

  8. Electrotechnics - AC motors. Asynchronous and brush-less motors - Lecture and exercises with solutions; Electrotechnique - Moteurs a courant alternatif. Moteurs asynchrones et brushless - Cours et problemes resolus

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, D.

    2005-07-01

    This book proposes a presentation of AC electric motors essentially based on physics and technology. Its originality consists in avoiding to use mathematical formulations (like Park's transformation). The modeling retained, which only uses magnetic momentum, magnetic fields and reluctance concepts, leads simply and naturally to the vectorial control principle. The book develops some lecture elements which includes some topics rarely considered like the dimensioning of an asynchronous motor or of a single-phase brush-less motor. Experimental results illustrate the physical phenomena described and many original problems are resolved and commented at the end of each chapter. Content: signals and systems in electrotechnics, torque and rotating magnetic fields generation, asynchronous machine in permanent regime, speed variation of the asynchronous motor, special asynchronous motors, synchronous machine in permanent regime, brush-less motor, note about step motors, note about inverters, index. (J.S.)

  9. Study of a photomultiplier for the measurement of low light flows by photon counting; Etude d'un photomultiplicateur en vue de la mesure des faibles flux lumineux par comptage de photons

    Energy Technology Data Exchange (ETDEWEB)

    Haye, Kleber

    1964-03-20

    'amplitude des impulsions ainsi que les variations relatives du rendement quantique pour diverses longueurs d'onde. Nous avons parallelement a l'etude par comptage mene une etude par la methode bien connue de mesure du courant moyen.

  10. The conditioning of radioactive waste by bitumen; Conditionnement des dechets radioactifs par le bitume

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Scheidhauer, J; Malabre, M [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1961-07-01

    The separation of radioactive sludge and waste by bitumen is studied. Results are given concerning various trials carried out on the lixiviation of the final product by water as a function of the pH, of the time, and of the composition. The conditions for carrying out this process of coating the waste are controlled from a radioactive point of view. (author) [French] L'isolement de boues radioactives et de dechets par le bitume est etudie. Les resultats de divers essais portant sur la lixiviation par l'eau du produit fini en fonction du pH, du temps et de la composition sont exposes. Les conditions de realisation de l'enrobage sont controlees au point de vue du risque radioactif. (auteur)

  11. suPAR remains uninfluenced by surgery in septic patients with bloodstream infection

    Directory of Open Access Journals (Sweden)

    Rabensteiner, Jasmin

    2016-07-01

    Full Text Available Surgical trauma induces activation of the immune system and may cause an increase of inflammatory biomarkers tested postoperatively in septic patients treated for bloodstream infection. The aim of this study was to determine the impact of surgical interventions on the novel sepsis biomarker soluble urokinase plasminogen activator receptor (suPAR and to compare results with those of routine laboratory parameters CRP, PCT, and IL-6 in patients with culture-proven bloodstream infection. Forty-six adult patients with positive blood culture undergoing minor or major surgical intervention were investigated, 12 blood culture positive patients served as control group. Blood was collected 24 hours before and after surgical intervention for determination of the sepsis biomarkers suPAR, CRP, PCT, and IL-6. Within the surgical study cohort, a non-significant increase of suPAR, CRP, and PCT was observed postoperatively ( 0.642; 0.773; 0.087. In contrast, a slight decrease of IL-6 ( 0.599 was observed. A significant correlation was calculated for the pre- and postoperative difference of CRP ( 0.028 and PCT and type of surgical intervention received: after minor surgical intervention only PCT decreased significantly (<0.001, while after major surgical interventions no significant differences were observed for all biomarkers evaluated. In the control group, a significant decrease of CRP ( 0.005 and PCT ( 0.005 was observed. In patients treated adequately for bloodstream infections, postoperative suPAR levels remained uninfluenced of the surgical trauma and might therefore be a reliable parameter for postoperative infectious monitoring. After minor surgical intervention, PCT seems to be the most reliable parameter.

  12. Control of pile power by measurement of the activity of the cooling fluid. The particular case of EL3; Controle de la puissance d'une pile par la mesure de l'activite du fluide de refroidissement. Cas particulier de EL 3

    Energy Technology Data Exchange (ETDEWEB)

    Lalere, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    In a high flux pile the presence of local absorbers makes the power difficult to measure. In any case thermodynamic measurements are sometimes not very accurate. Another possible method could be the measurement of the cooling fluid activity. This has been tried on the heavy water circuit of EL3. In the first part of this report we give some qualitative indications of the various activities present in the heavy water in circulation. After this, the activity of the element chosen has been calculated. Finally, the results obtained from EL3 are given. (author) [French] Dans une pile a haut flux, la presence d'absorbeurs localises rend la mesure de la puissance difficile. Les mesures thermodynamiques sont par ailleurs parfois peu precises. Un autre moyen pourrait etre la mesure de l'activite du fluide de refroidissement. C'est ce qui a ete essaye sur le circuit eau lourde de EL3. Dans une premiere partie, nous donnons quelques indications qualitatives sur les diverses activites presentes dans l'eau lourde en circulation. Ensuite, nous avons fait le calcul de l'activite de l'element choisi. Enfin, nous avons mentionne les resultats qui ont ete obtenus EL3. (auteur)

  13. Serum suPAR in patients with FSGS: trash or treasure?

    NARCIS (Netherlands)

    Maas, R.J.H.; Deegens, J.K.J.; Wetzels, J.F.M.

    2013-01-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both

  14. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  15. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-06-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  16. Tratamiento acupuntural vs parálisis facial periférica de Bell

    OpenAIRE

    Paz Latorre, Elvia Isabel

    1998-01-01

    Se realizó un ensayo clínico sobre la efectividad del tratamiento acupuntural en 170 pacientes afectados de Parálisis Facial Periférica de Bell que acudieron a la clínica de Medicina Natural ¨ Carlos J. Finlay ¨ en el período comprendido entre enero y julio 1996. La muestra se divide en dos grupos: control y de estudio, con 85 pacientes cada uno. Los tratamientos empleados fueron esteroides para el grupo control y acupuntura para el grupo estudio con el objetivo de comparar los resultados de ...

  17. Intrinsic and integrative properties of substantia nigra pars reticulata neurons

    Science.gov (United States)

    Zhou, Fu-Ming; Lee, Christian R.

    2011-01-01

    The GABA projection neurons of the substantia nigra pars reticulata (SNr) are output neurons for the basal ganglia and thus critical for movement control. Their most striking neurophysiological feature is sustained, spontaneous high frequency spike firing. A fundamental question is: what are the key ion channels supporting the remarkable firing capability in these neurons? Recent studies indicate that these neurons express tonically active TRPC3 channels that conduct a Na-dependent inward current even at hyperpolarized membrane potentials. When the membrane potential reaches −60 mV, a voltage-gated persistent sodium current (INaP) starts to activate, further depolarizing the membrane potential. At or slightly below −50 mV, the large transient voltage-activated sodium current (INaT) starts to activate and eventually triggers the rapid rising phase of action potentials. SNr GABA neurons have a higher density of (INaT), contributing to the faster rise and larger amplitude of action potentials, compared with the slow-spiking dopamine neurons. INaT also recovers from inactivation more quickly in SNr GABA neurons than in nigral dopamine neurons. In SNr GABA neurons, the rising phase of the action potential triggers the activation of high-threshold, inactivation-resistant Kv3-like channels that can rapidly repolarize the membrane. These intrinsic ion channels provide SNr GABA neurons with the ability to fire spontaneous and sustained high frequency spikes. Additionally, robust GABA inputs from direct pathway medium spiny neurons in the striatum and GABA neurons in the globus pallidus may inhibit and silence SNr GABA neurons, whereas glutamate synaptic input from the subthalamic nucleus may induce burst firing in SNr GABA neurons. Thus, afferent GABA and glutamate synaptic inputs sculpt the tonic high frequency firing of SNr GABA neurons and the consequent inhibition of their targets into an integrated motor control signal that is further fine-tuned by neuromodulators

  18. Rapid evaluation of the neutron dose following a criticality accident by measurement of {sup 24}Na activity; Evaluation rapide de la dose de neutrons a la suite d'un accident de criticite par mesure de l'activite de {sup 24}Na

    Energy Technology Data Exchange (ETDEWEB)

    Estournel, R [Centre de Production de Plutonium de Marcoule, Service de Protection contre les Rayonnements, 30 (France); Henry, Ph [Centre de Production de Plutonium de Marcoule, Section Medicale et Sociale, 30 (France); Beau, P; Ergas, A [Commissariat a l' Energie Atomique, Service d' Hygiene Atomique, Dept. de la Protection Sanitaire, Chusclan, (France)

    1966-07-01

    By external measurement of the gamma activity of {sup 24}Na induced in the human organs by a neutron flux during a criticality accident, it is possible to evaluate the personal dose received. Detectors designed for everyday use in health physics can be applied to these measurements, and this is described in the first part of the work. The response of a certain number of induced-activity detectors is presented. The induced activity-dose relationship is studied theoretically in the second part taking into account the neutron spectrum to which the individual has been subjected. The characteristic spectra of three possible types of accident have been used for deducing this relationship. The results obtained show that the method is sufficiently sensitive for present purposes. The accuracy of this method for calculating the dose received during an experiment is discussed. (authors) [French] La mesure par detection externe de l'activite gamma du sodium 24 induit dans l'organisme humain par un flux de neutrons lors d'un accident de criticite rend possible l'evaluation de la dose recue par un individu irradie. L'utilisation de detecteurs d'un emploi courant en radioprotection fait l'objet d'une experimentation qui constitue la premiere partie de cette etude. La reponse d'un certain nombre de detecteurs a une activite induite connue est presentee. La relation dose-activite induite, est etudiee, de maniere theorique, dans la seconde partie, correlativement au spectre des neutrons qui ont atteint l'individu irradie. Les spectres caracteristiques de trois types d'accidents possibles ont ete retenus pour l'etablissement de ces relations. Les resultats obtenus montrent que la methode satisfait avec une sensibilite suffisante au but recherche. La precision avec laquelle on peut ainsi calculer la dose recue au cours d'un accident de criticite est discutee. (auteurs)

  19. An investigation into preparation of silver sheathed superconducting wires with a high critical temperature; Etude des problemes poses par l'elaboration de fils supraconducteurs gaines argent a haute temperature critique

    Energy Technology Data Exchange (ETDEWEB)

    Chaffron, Laurent

    1992-04-03

    conditionnement de la poudre, le renforcement de la gaine, le cycle de la temperature et l'atmosphere des traitements thermiques, nous avons d'abord fortement reduit les effets nefastes des 4 premieres causes. Puis, nous nous sommes efforces de texturer fortement la ceramique par frittage fluage et sommes ainsi arrives a la conclusion que la texturation etait une condition necessaire mais non suffisante pour atteindre un courant de transport eleve, car ce dernier reste limite par la presence de phase amorphe dans de trop nombreux joints de grains. Finalement en fondant le materiau dans un gradient de temperature et en le deplacant a tres faible vitesse, nous avons obtenu des materiaux a joints de grains propres qui presentent des courants critiques tres eleves, mais la technique est beaucoup trop lente pour produire des fils de grande longueur. (auteur)

  20. Diagnostic accuracy of soluble urokinase plasminogen activator receptor (suPAR) for prediction of bacteremia in patients with systemic inflammatory response syndrome.

    Science.gov (United States)

    Hoenigl, Martin; Raggam, Reinhard B; Wagner, Jasmin; Valentin, Thomas; Leitner, Eva; Seeber, Katharina; Zollner-Schwetz, Ines; Krammer, Werner; Prüller, Florian; Grisold, Andrea J; Krause, Robert

    2013-02-01

    Soluble urokinase plasminogen activator receptor (suPAR) serum concentrations have recently been described to reflect the severity status of systemic inflammation. In this study, the diagnostic accuracy of suPAR, C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) to predict bacteremia in patients with systemic inflammatory response syndrome (SIRS) was compared. A total of 132 patients with SIRS were included. In 55 patients blood cultures had resulted positive (study group 1, Gram positive bacteria: Staphylococcus aureus and Streptococcus spp., n=15; study group 2, Gram-negative bacteria, n=40) and 77 patients had negative blood culture results (control group, n=77). Simultaneously with blood cultures suPAR, CRP, PCT, IL-6 and white blood count (WBC) were determined. SuPAR values were significantly higher in study group 1 (median 8.11; IQR 5.78-15.53; p=0.006) and study group 2 (median 9.62; IQR 6.52-11.74; p<0.001) when compared with the control group (median 5.65; IQR 4.30-7.83). ROC curve analysis revealed an AUC of 0.726 for suPAR in differentiating SIRS patients with bacteremia from those without. The biomarkers PCT and IL-6 showed comparable results. Regarding combinations of biomarkers multiplying suPAR, PCT and IL-6 was most promising and resulted in an AUC value of 0.804. Initial suPAR serum concentrations were significantly higher (p=0.028) in patients who died within 28 days than in those who survived. No significant difference was seen for PCT, IL-6 and CRP. In conclusion, suPAR, IL-6 and PCT may contribute to predicting bacteremia in SIRS patients. Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  1. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-09-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  2. Par Pond vegetation status Summer 1995 -- October survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-11-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  3. Inhibiting trophoblast PAR-1 overexpression suppresses sFlt-1-induced anti-angiogenesis and abnormal vascular remodeling: a possible therapeutic approach for preeclampsia.

    Science.gov (United States)

    Zhao, Yin; Zheng, YanFang; Liu, XiaoXia; Luo, QingQing; Wu, Di; Liu, XiaoPing; Zou, Li

    2018-03-01

    Is it possible to improve vascular remodeling by inhibiting the excessive expression of protease-activated receptor 1 (PAR-1) in trophoblast of abnormal placenta? Inhibition of trophoblast PAR-1 overexpression may promote placental angiogenesis and vascular remodeling, offering an alternative therapeutic approach for preeclampsia. PAR-1 is high-affinity receptor of thrombin. Thrombin increases sFlt-1 secretion in trophoblast via the activation of PAR-1. It is reported that the expression of both thrombin and PAR-1 expression are increased in placentas of preeclampsia patients compared with normal placentas. Trophoblast cells were transfected with PAR-1 short hairpin RNA (shRNA) or PAR-1 overexpression plasmids in vitro. Tube formation assays and a villus-decidua co-culture system were used to study the effect of PAR-1 inhibition on placental angiogenesis and vascular remodeling, respectively. Placentas from rats with preeclampsia were transfected with PAR-1 shRNA to confirm the effect of inhibiting PAR-1 overexpression in placenta. The trophoblast cell line HTR-8/SVneo was transfected with PAR-1 shRNA or PAR-1 overexpression plasmids. After 48 h, supernatant was collected and the level of sFlt-1 secretion was measured by ELISA. Human umbilical cord epithelial cells and a villus-decidua co-culture system were treated with conditioned media to study the effect of PAR-1 inhibition on tube formation and villi vascular remodeling. A preeclampsia rat model was established by intraperitoneal injection of L-NAME. Plasmids were injected into the placenta of the preeclampsia rats and systolic blood pressure was measured on Days 15 and 19. The effect of different treatments was evaluated by proteinuria, placental weights, fetal weights and fetal numbers in study and control groups. The level of serum sFlt-1 in rats with preeclampsia was also measured. Changes in the placenta microvessels were studied by histopathological staining. PAR-1 shRNA inhibited PAR-1 expression and

  4. [Ambroise Paré, his death and his historians].

    Science.gov (United States)

    Dumaître, P

    2001-01-01

    Ambroise Paré died December the 20th., 1590. What happened after his death and what are we knowing about his life? Never forgotten, though a lack of care, we were waiting till the XIXth. century to get recollection upon a subject sustained only by accounts of his travels. After Percy, a surgeon who tried to write Paré's biography through the "Biographie universelle ancienne et moderne, de Michaud (1822)" and some second rank authors, Malgaigne is the first who inside a printing of the "Oeuvres complétes de Paré (1840-41)" has a fine look upon the question, though his work is incomplete and allows many mistakes. Doctors Chéreau and Jal, an historian, analysing civil status records, gave new information enlarged by doctors Le Paulmier, Turner and the U.S. native Janet Doe.

  5. Keratometric alterations following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy.

    Science.gov (United States)

    Citirik, Mehmet; Batman, Cosar; Bicer, Tolga; Zilelioglu, Orhan

    2009-09-01

    To assess the alterations in keratometric astigmatism following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy. Sixteen consecutive patients were enrolled into the study. Conventional vitrectomy was applied to eight of the cases and 25-gauge transconjunctival sutureless vitrectomy was performed in eight patients. Keratometry was performed before and after the surgery. In the 25-gauge transconjunctival sutureless pars plana vitrectomy group, statistically significant changes were not observed in the corneal curvature in any post-operative follow-up measurement (p > 0.05); whereas in the conventional pars plana vitrectomy group, statistically significant changes were observed in the first postoperative day (p = 0.01) and first postoperative month (p = 0.03). We noted that these changes returned to baseline in three months (p = 0.26). Both 25-gauge transconjunctival sutureless and conventional pars plana vitrectomy are effective surgical modalities for selected diseases of the posterior segment. Surgical procedures are critical for the visual rehabilitation of the patients. The post-operative corneal astigmatism of the vitrectomised eyes can be accurately determined at least two months post-operatively.

  6. Cyclanthaceae no estado do Pará, Brasil Cyclanthaceae in Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Eduardo da Silva Leal

    2012-12-01

    Full Text Available Cyclanthaceae apresenta distribuição exclusiva na região neotropical sendo bem diversificada nas terras baixas das florestas pluviais tropicais, ocorrendo do sul do México até a Mata Atlântica do sul do Brasil. Consistem de ervas terrestres, epífitas, hemiepífitas ou lianas. O tratamento taxonômico de Cyclanthaceae no Pará foi baseado em coleções de herbário, trabalhos de campo e consulta a bibliografia referente à família. Foram registradas 11 espécies: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. e Thoracocarpus bissectus (Vell. Harling. São apresentadas chave de identificação, descrições e ilustrações das espécies, além de comentários sobre distribuição geográfica, hábitat e período de floração e frutificação.Cyclanthaceae is a family with a distribution exclusively in the Neotropics and is well diversified in lowland rainforests, occurring from southern Mexico to the Atlantic Forest of southern Brazil. The family consists of terrestrial herbs, epiphytes, hemiepiphytes and lianas. This taxonomic treatment of the Cyclanthaceae from the state of Pará was based on herbarium specimens, fieldwork, and the literature. Eleven species were recorded: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. and Thoracocarpus bissectus (Vell. Harling. An identification key, descriptions and illustrations of species are presented. Additional information on the geographic distribution, habitat, and flowering and

  7. Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group

    International Nuclear Information System (INIS)

    Sorio, Claudio; Scarpa, Aldo; Mafficini, Andrea; Furlan, Federico; Barbi, Stefano; Bonora, Antonio; Brocco, Giorgio; Blasi, Francesco; Talamini, Giorgio; Bassi, Claudio

    2011-01-01

    The urokinase plasminogen activator receptor is highly expressed and its gene is amplified in about 50% of pancreatic ductal adenocarcinomas; this last feature is associated with worse prognosis. It is unknown whether the level of its soluble form (suPAR) in urine may be a diagnostic-prognostic marker in these patients. The urinary level of suPAR was measured in 146 patients, 94 pancreatic ductal adenocarcinoma and 52 chronic pancreatitis. Urine from 104 healthy subjects with similar age and gender distribution served as controls. suPAR levels were normalized with creatinine levels (suPAR/creatinine, ng/mg) to remove urine dilution effect. Urinary suPAR/creatinine values of pancreatic ductal adenocarcinoma patients were significantly higher (median 9.8; 25 th -75 th percentiles 5.3-20.7) than those of either healthy donors (median 0; 0-0.5) or chronic pancreatitis patients (median 2.7; 0.9-4.7). The distribution of values among cancer patients was widespread and asymmetric, 53% subjects having values beyond the 95 th percentile of healthy donors. The values of suPAR/creatinine did not correlate with tumour stage, Ca19-9 or CEA levels. Higher values correlated with poor prognosis among non-resected patients at univariate analysis; multivariate Cox regression identified high urinary suPAR/creatinine as an independent predictor of poor survival among all cancer patients (odds ratio 2.10, p = 0.0023), together with tumour stage (stage III odds ratio 2.65, p = 0.0017; stage IV odds ratio 4.61, p < 0.0001) and female gender (odds ratio 1.85, p = 0.01). A high urinary suPAR/creatinine ratio represents a useful marker for the identification of a subset of patients with poorer outcome

  8. Theory, analysis and applications of the operation of the superconducting transformer supplying a direct current to a non-dissipative superconducting charge circuit; Theorie, analyse et applications du fonctionnement du transformateur supraconducteur alimentant en courant continu un circuit de charge supraconducteur non dissipatif

    Energy Technology Data Exchange (ETDEWEB)

    Sole, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-07-01

    The author derives the very simple equations governing the operation of a transformer with superconducting windings supplying direct current to a non-dissipative superconducting charge circuit. An analysis of the various possible modes of operation with direct or slowly varying current raises the problem of the magnetic core. The study. leads to a conclusion which a priori might be surprising: the elimination of the magnetic core and the use of a primary super-conductor. An example of a possible realization of such a transformer is given as an indication, and the present prospects for different applications are considered. (author) [French] L'auteur etablit les equations tres simples de fonctionnement du transformateur a enroulements supraconducteurs alimentant en courant continu un circuit de charge supraconducteur non dissipatif. L'analyse de divers modes de fonctionnement possibles en courant continu ou lentement variable souleve le probleme du noyau magnetique. L'etude aboutit a une conclusion qui a priori aurait pu surprendre: l'elimination du noyau magnetique et l'utilisation d'un primaire supraconducteur. Un exemple de realisation possible d'un tel transformateur est donne a titre indicatif et les perspectives d'applications actuelles sont envisagees. (auteur)

  9. On the phenomenon of the reversal of the cooling current in the hot pipes of a swimming-pool type pile cooled by forced convection; Sur un phenomene de renversement du courant de refrigeration dans les canaux chauds d'une pile piscine refroidie en convection forcee

    Energy Technology Data Exchange (ETDEWEB)

    Boure, J [Commissariat a l' Energie Atomique, Grenoble (France).Centre d' Etudes Nucleaires

    1961-07-01

    It is shown, for a swimming-pool type pile cooled by forced convection (general flow downwards), that a permanently stable regime with downward flow in all the channels is not possible when the flow is below a critical value for a given power. In the hot channels the natural convection then becomes preponderant, the direction of the flow is reversed and a permanently stable regime exists for which the flow is upwards in the hot channels. Calculations are made, with simplifying hypotheses in the case of Melusine. (author) [French] Pour une pile piscine refrigeree en convection forcee (ecoulement global descendant), on montre qu'un regime permanent stable avec ecoulement descendant dans tous les canaux est impossible lorsque le debit est inferieur a une valeur critique pour une puissance donnee. Dans les canaux chauds, la convection naturelle l'emporte alors, le sens du courant s'inverse et un regime permanent stable existe, pour lequel le courant est ascendant dans les canaux chauds. On fait les calculs, avec des hypotheses simplificatrices, dans le cas de Melusine. (auteur)

  10. Surinfection des contusions cerebrales par voie hematogene ...

    African Journals Online (AJOL)

    Eleven days after admission, right hemiparesis, aphasia appeared, in a febrile context (Ø 39.4). A control scan showed a left empyema associated with a right parietal abscess. Blood culture and bacteriological sampling of wound isolated a staphylococcus aureus. A triple antibiotic had allowed a favorable evolution.

  11. Diseno macromolecular par transferencia de cadena

    NARCIS (Netherlands)

    Heuts, J.P.A.; Munoz Bonilla, A.

    2010-01-01

    In this overview article, a brief description and discussion is given about the controlled radical techniques which are based on chain transfer, i.e., Catalytic Chain Transfer (CCT) and Reversible Addition-Fragmentation chain Transfer (RAFT). The CCT is an incredibly efficient method for making

  12. Moniliophthora roreri (Cif y Par Evans et al. in the crop of cocoa

    Directory of Open Access Journals (Sweden)

    Fernando David Sánchez Mora

    2012-09-01

    Full Text Available More than a century, cacao (Theobroma cacao L. in Ecuador has been an important source of income for farmers and currency for the country, becoming one of the biggest exporters worldwide. Then, gradually lost that status due to the attack of diseases, including moniliasis caused by [Moniliophthora roreri (Cif and Par Evans et al.]. It can cause damage of up to 80% in production. Currently there is little scientific date information on its occurrence, symptoms, etiology, epidemiology, life cycle management or control strategies of that disease, by performing this review both these important topics, bringing with it to this area of knowledge.

  13. Controlled power supply for isotopes separator; Alimentations regulees pour separateur d'isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Lavaitte, A; Pottier, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1953-07-01

    This equipment is destined to equip the separator of isotopes who is the subject of the CEA report n 138. It includes: - a controlled power supply in voltage. - a controlled power supply in current. The spectra of fluctuations of these assembly is different in the two cases. (authors) [French] Cet equipement est destine a equiper le separateur d'isotopes qui fait l'objet du rapport C.E.A. n 138. Il comprend: - une alimentation regulee en tension. - une alimentation regulee en courant. Le spectre de fluctuations de ces ensembles est different dans les deux cas. (auteurs)

  14. Deposition of thin layers of boron nitrides and hydrogenated microcrystalline silicon assisted by high current direct current arc plasma; Deposition assistee par un plasma a arc a haut courant continu de couches minces de Nitrure de Bore et de Silicium microcristallin hydrogene

    Energy Technology Data Exchange (ETDEWEB)

    Franz, D. [Ecole Polytechnique Federale de Lausanne, Centre de Recherches en Physique des Plasmas (CRPP), CH-1015 Lausanne (Switzerland)

    1999-09-01

    In the frame of this thesis, a high current direct current arc (HCDCA) used for the industrial deposition of diamond, has been adapted to study the deposition of two types of coatings: a) boron nitride, whose cubic phase is similar to diamond, for tribological applications, b) hydrogenated microcrystalline silicon, for applications in the semiconductor fields (flat panel displays, solar cells,...). For the deposition of these coatings, the substrates were placed in the diffusion region of the arc. The substrate heating is mainly due to atomic species recombining on its surface. The deposition temperature, varying from 300 to 900 {sup o}C according to the films deposited, is determined by the substrate position, the arc power and the injected gas fluxes, without the use of any external heating or cooling system. Measurements performed on the arc plasma show that the electronic temperature is around 2 eV (23'000 K) while the gas temperature is lower than 5500 K. Typical electronic densities are in the range of 10{sup 12}-10{sup 1'}3 cm{sup -3}. For the deposition of boron nitride films, different boron precursors were used and a wide parameter range was investigated. The extreme difficulty of synthesising cubic boron nitride films by chemical vapour deposition (CVD) did not allow to stabilize the cubic phase of boron nitride in HCDCA. Coatings resulted in hexagonal or amorphous boron nitride with a chemical composition close to stoichiometric. The presence of hydrogen leads to the deposition of rough and porous films. Negative biasing of the samples, for positive ion bombardment, is commonly used to stabilize the cubic phase. In HCDCA and in our biasing range, only a densification of the films could be observed. A boron nitride deposition plasma study by infrared absorption spectroscopy in a capacitive radio frequency reactor has demonstrated the usefulness of this diagnostic for the understanding of the various chemical reactions which occur in this kind of plasma. Diborane dissociation, the different reactions and new species created in the gas phase, such as aminoborane, containing boron-nitrogen bonds, reveals a rich chemistry in the plasma phase. A large amount of atomic hydrogen is necessary to deposit hydrogenated microcrystalline silicon coatings. The study of HCDCA regarding the deposition of diamond has shown that this arc efficiently dissociates molecular hydrogen by way of intermediate vibrationally excited states. This efficient dissociation has allowed the fast deposition (up to 0.6 microns per minute) of highly crystalline silicon films, even without any addition of molecular hydrogen, where the atomic hydrogen was created by the molecular dissociation of silane (SiH{sub 4}). The nature of the deposition precursors is highly dependent on the magnetic field used to confine the arc. At low field, the deposition of hydrogenated silicon radicals created in the plasma leads to columnar growth, whereas with an increase of the magnetic field, the film growth is probably dominated by the deposition of crystallites created in the plasma phase, whose size increases with the field. Moreover, a strong dependence of the film morphology on the deposition parameters has been observed, in particular, regarding the substrate temperature, the hydrogen dilution and the magnetic field. This new deposition technique of hydrogenated microcrystalline silicon is promising for industrial applications. (author)

  15. Parasitisme de Dacryodes edulis par le genre Tapinanthus ...

    African Journals Online (AJOL)

    SARAH

    31 août 2013 ... Parasitisme de Dacryodes edulis par le genre. Tapinanthus (Loranthaceae) et répartition de la myrmécofaune associée à Logbessou Plateau. (Douala, Cameroun). Massako F1*, Tchatat M2, Mony R3, Ladoh Yemeda CF1, Dibong SD1,4,5. 1Laboratoire de Biologie et Physiologie des Organismes ...

  16. Parasitisme des champs semenciers de cacaoyers par les ...

    African Journals Online (AJOL)

    SARAH

    30 janv. 2015 ... J. Appl. Biosci. Parasitisme des champs semenciers de cacaoyers par les loranthaceae dans la localité de Nkoemvone (sud Cameroun). 7795 to the various clones, Phragmanthera capitata was the most abundant Loranthaceae; the level of parasitism of cacao trees is more important at the cacao trees of ...

  17. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  18. Indications and visual outcome of first hundred pars plana ...

    African Journals Online (AJOL)

    Objective: To review the indications and visual outcome of the first one hundred pars plana vitrectomies performed at the newly established surgical retina unit of Makkah Specialist Eye Hospital, Kano, Kano State, Nigeria. Materials and Methods: Aretrospective chart review was performed. Data recorded from the patient ...

  19. Epuration des effluents industriels par électroflottation Belkacem ...

    African Journals Online (AJOL)

    étudié la séparation de quelques métaux lourds tels que le fer, le nickel, ... the separation of some heavy metals such as iron, nickel, copper, zinc, lead and ... généralement basées sur l'adsorption (par ... Différents essais de concentration en.

  20. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  1. Priapisme induit par la chlorpromazine: A propos de deux cas

    Directory of Open Access Journals (Sweden)

    I. Marrag

    2016-06-01

    Le priapisme veineux est une urgence urologique. Il constitue un des effets secondaires des neuroleptiques parmi les quels la chlorpromazine. Cet effet iatrogène, qui est rare mais grave, doit être connu par les cliniciens afin d’être mieux prévenu pour éviter les séquelles érectiles.

  2. La lecture de Merleau-Ponty par Renaud Barbaras

    Czech Academy of Sciences Publication Activity Database

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015), s. 1-6 ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  3. Par Pond vegetation status summer 1995 - July survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-07-01

    A survey of the emergent shoreline aquatic plant, communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet (61 meters) above mean sea level, and continued with this July survey. Aquatic plant communities, similar to the pre-drawdown Par Pond communities, are becoming reestablished. Beds of maidencane (Panicum hemitomon), lotus (Nelumbo lutea), water lily (Nymphaea odorata), and watershield (Brasenia schreberi) are now extensive and well established. In addition, within isolated coves, extensive beds of water lilies and spike-rush (Eleocharis sp.) are common. Cattail occurrence has increased since refill, but large beds common to Par Pond prior to the drawdown have not formed. Invasion of willow (Salix sp.) and red maple (Acer rubrum) occurred along the lake shoreline during drawdown. The red maples along the present shoreline are beginning to show evidence of stress and mortality from flooding over the past four months. Some of the willows appear to be stressed as well. The loblolly pines (Pinus taeda), which were flooded in all but the shallow shoreline areas, are now dead. Future surveys are planned for the growing seasons of 1995, 1996, and 1997, along with the evaluation of satellite data for mapping the areal extent of the macrophyte beds of Par Pond

  4. fortification des farines tropicales par l'introduction de proteines ...

    African Journals Online (AJOL)

    2Université d'Abomey Calavy, Faculté des Sciences et Techniques, Bénin ... valeur recommandée par le Codex Alimentarius pour ce type de complément alimentaire destiné aux enfants. ..... neurotransmission, coagulation sanguine et.

  5. Estuarine and offshore fishing yield statistics and fishery policies in the state of Pará

    Directory of Open Access Journals (Sweden)

    Ivan Furtado Júnior

    2006-08-01

    Full Text Available The coast of Pará State extends for 562 km and it counts on 123 artisan-fishing communities, distributed along 17 coastal municipal districts. In this area of the State, it highlights the presence of growth of mangroves, streams, rivers and estuaries. All those factors that favor the fishing productivity hinder the systematic control of the landings a lot and with consequence in obtaining fishing production statistics. This work objective is to present the statistics of fishing production for species in landing volume, in the estuarine and marine areas of Pará Estate and to analyze the fishing police for the systems of industrial and artisan production in the period from 1997 to 2003. To esteem the fishing productions of the estuarine and marine areas in Pará State. There was monthly control on the boat in activity for type of fishing gear used and accomplished samples of the landings of each one of those combinations of boat fishing gear. In the studied area, the municipal districts that concentrate the largest landings are Belém, Bragança and Vigia. The tuna and billfish captures started having some importance from 2000 in Belém City and from 2002 in Belém city and municipal district of Curuçá. The species or groups of more important species in capture volume are yellow weakfish, Thomas sea catfish, Spanish mackerel, sharks, Caribbean red snapper, king weakfish, crab, marine catfish and shrimp and, in economic, value lobsters, shrimp and Caribbean red snapper.

  6. The role of pars flaccida in human middle ear sound transmission.

    Science.gov (United States)

    Aritomo, H; Goode, R L; Gonzalez, J

    1988-04-01

    The role of the pars flaccida in middle ear sound transmission was studied with the use of twelve otoscopically normal, fresh, human temporal bones. Peak-to-peak umbo displacement in response to a constant sound pressure level at the tympanic membrane was measured with a noncontacting video measuring system capable of repeatable measurements down to 0.2 micron. Measurements were made before and after pars flaccida modifications at 18 frequencies between 100 and 4000 Hz. Four pars flaccida modifications were studied: (1) acoustic insulation of the pars flaccida to the ear canal with a silicone rubber baffle, (2) stiffening the pars flaccida with cyanoacrylate cement, (3) decreasing the tension of the pars flaccida with a nonperforating incision, and (4) perforation of the pars flaccida. All of the modifications (except the perforation) had a minimal effect on umbo displacement; this seems to imply that the pars flaccida has a minor acoustic role in human beings.

  7. 184 Évaluation du niveau de pollution par les métaux lourds des ...

    African Journals Online (AJOL)

    Afrique Sciences

    l'environnement. L'importance de l'étude de la pollution des eaux a cru considérablement depuis le début des années soixante dans le monde entier à cause des effets .... Le courant d'alimentation était de 4 mA. .... ces eaux ont été comparées à la norme sur les eaux de boisson de l'Organisation Mondiale de la Santé [18].

  8. Apoplejía pituitaria con parálisis del III par craneal: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Miguel Pinto Valdivia

    2011-10-01

    Full Text Available Se describe el caso de un varón de 65 años de edad, sin antecedentes patológicos de importancia, que acudió a emergencia del Hospital Nacional Cayetano Heredia por presentar cefalea intensa y ptosis palpebral izquierda. El examen físico mostró parálisis aislada del III par craneal izquierdo. Los análisis de laboratorio mostraron hiponatremia e hipopituitarismo y la resonancia magnética nuclear un adenoma pituitario con áreas de hemorragia e invasión de los senos cavernosos. El tratamiento incluyó glucocorticoides y descompresión quirúrgica transesfenoidal. La anatomía patológica confirmó el diagnóstico de infarto hemorrágico de un adenoma pituitario. El paciente fue dado de alta con terapia sustitutiva de levotiroxina y prednisona. La ptosis palpebral izquierda se recuperó en forma parcial. La apoplejía pituitaria es un síndrome clínico producido por un proceso expansivo dentro de la silla turca, secundario a hemorragia o infarto de un adenoma pituitario, que se caracteriza por cefalea, déficit visual, oftalmoplejía y alteración del nivel de conciencia. Este proceso expansivo puede comprimir los pares craneales en los senos cavernosos, produciendo diferentes grados de parálisis de los músculos oculomotores. La parálisis aislada del III par craneal es rara.(Rev Med Hered 2011;22:186-189.

  9. Épidémiologie de l'intoxication par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Introduction: L'intoxication par envenimation est l'ensemble des manifestations locales et générales induites par la pénétration dans l'organisme d'une substance toxique produite par un animal venimeux. Le but de notre travail était d'étudier les signes cliniques des intoxications par envenimation chez les enfants de 0 à 15 ...

  10. Continuous analytical control of the streaming waters in a uranium treatment plant and of various chemical products using automatic discharge valves; Controle par analyse en continu des eaux de ruissellement d'une usine traitant de l'uranium et divers produits chimiques avec commande automatique des vannes de decharge

    Energy Technology Data Exchange (ETDEWEB)

    Archimbaud, M; Simeon, C [Commissariat a l' Energie Atomique, Pierrelatte (France)

    1968-07-01

    This report describes a method for controlling the streaming waters produced by the Pierrelatte Centre; it is based on continuous analysis, with simultaneous recording of the species liable to be found accidentally in the corresponding hydrological circuits (chlorides, fluorides, chromium VI, uranium). An alarm set off at pre-determined thresholds leads to an automatic cutting off of the discharge valves; the outward flow of the waters is thus interrupted. This study has shown the various applications which can be found for this water control method, and gives an idea of the cost price. (authors) [French] Ce rapport decrit un mode de controle des eaux de ruissellement provenant du Centre de Pierrelatte base sur une analyse en continu, avec enregistrement des corps susceptibles de se retrouver accidentellement dans les reseaux hydrologiques correspondants (chlorures, fluorures, chrome VI, uranium). Le declenchement d'une alarme a partir de seuils choisis permet de fermer automatiquement les vannes de decharge et d'arreter ainsi l'ecoulement vers l'exterieur. Cette etude montre quelles peuvent etre les diverses applications de cette methode de controle des eaux et elle indique un ordre de grandeur du prix de revient. (auteurs)

  11. Soluble urokinase plasminogen activator receptor (suPAR) in acute care

    DEFF Research Database (Denmark)

    Rasmussen, Line Jee Hartmann; Ladelund, Steen; Haupt, Thomas Huneck

    2016-01-01

    for age, sex, Charlson score and C reactive protein. Area under the curve for receiver operating characteristics curve analysis of suPAR for 30-day mortality was 0.84 (95% CI 0.81 to 0.86). Furthermore, in the entire cohort, women had slightly higher suPAR compared with men, and suPAR was associated...

  12. Movement and equipositioning of plasmids by ParA filament disassembly

    DEFF Research Database (Denmark)

    Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

    2009-01-01

    , plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...

  13. Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy.

    Science.gov (United States)

    Rwibasira Rudinga, Gamariel; Khan, Ghulam Jilany; Kong, Yi

    2018-02-14

    Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR). Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  14. Protease-Activated Receptor 4 (PAR4: A Promising Target for Antiplatelet Therapy

    Directory of Open Access Journals (Sweden)

    Gamariel Rwibasira Rudinga

    2018-02-01

    Full Text Available Cardiovascular diseases (CVDs are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs, including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR. Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  15. Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway

    International Nuclear Information System (INIS)

    Li, Taiyuan; Liu, Dongning; Lei, Xiong; Jiang, Qunguang

    2017-01-01

    Partitioning defective 3-like protein (Par3L) is a recently identified cell polarity protein that plays an important role in mammary stem cell maintenance. Previously, we showed that high expression of Par3L is associated with poor survival in malignant colorectal cancer (CRC), but the underlying mechanism remained unknown. To this end, we established a Par3L knockout colorectal cancer cell line using the CRISPR/Cas system. Interestingly, reduced proliferation, enhanced cell death and caspase-3 activation were observed in Par3L knockout (KO) cells as compared with wildtype (WT) cells. Consistent with previous studies, we showed that Par3L interacts with a tumor suppressor protein liver kinase B1 (Lkb1). Moreover, Par3L depletion resulted in abnormal activation of Lkb1/AMPK signaling cascade. Knockdown of Lkb1 in these cells could significantly reduce AMPK activity and partially rescue cell death caused by Par3L knockdown. Furthermore, we showed that Par3L KO cells were more sensitive to chemotherapies and irradiation. Together, these results suggest that Par3L is essential for colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway, and is a putative therapeutic target for CRC. - Highlights: • Par3L knockout using the CRISPR/Cas system induces apoptosis in colorectal cancer cells. • Par3L interacts with Lkb1 and regulates the activity of AMPK signaling cascade. • Par3L knockout cells are more sensitive to treatment of different chemotherapy drugs and irradiation.

  16. Brésil : La contamination par le mercure en Amazonie | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 janv. 2011 ... En tentant de déceler la source de la contamination de l'Amazone par le ... par Jean-Rémy Davy Guimaraes de l'Université fédérale de Rio de Janeiro ... ces mattes est circonscrite par la conservation et la restauration en rive.

  17. Possibilities of long duration generation of vapour of iodine 131 in the air for its trapping in French activated carbons; Possibilites de generation de longue duree dans l'air de vapeur d'iode 131 en vue de son piegeage par les charbons actifs francais

    Energy Technology Data Exchange (ETDEWEB)

    Billard, F.; Chevalier, G.; Pradel, J.

    1962-12-17

    As previous studies performed on activated carbon showed that it was necessary to possess a long duration iodine generator to determine the scope of application of some advanced theories concerning the trap mechanism of different forms of radio-iodines, the authors present a generator which uses the high temperature oxidation of sodium iodide by an air stream or an oxygen stream. A version of this apparatus using a 5 Curie source is planned to check the operation of a trap of 100.000 m{sup 3}/h with a purification coefficient of 10{sup 4}, and aimed at being mounted on the venting circuit of a nuclear reactor enclosure [French] Les etudes que nous avons effectuees sur les charbons actifs nous ont montre qu'il etait necessaire de posseder un generateur d'iode de longue duree pour preciser le domaine d'application de certaines theories avancees concernant le mecanisme de piegeage des differentes formes de radioiodes. Un generateur utilisant l'oxydation de l'iodure de sodium a chaud par un courant d'air ou d'oxygene est decrit. Une version de cet appareil utilisant une source de 5 curies est prevue pour verifier le bon fonctionnement d'un piege de 100.000 m{sup 3}/h ayant un coefficient d'epuration de 10{sup 4} est destine a etre place sur le circuit de ventilation de l'enceinte d'un reacteur nucleaire. (auteurs)

  18. Study of the retention of fission products by a few common minerals. Application to the treatment of medium activity effluents (1962); Etude de la retention des produits de fission par quelques mineraux usuels. Application aux traitements d'effluents de moyenne activite specifique (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Auchapt, J M [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1962-07-01

    The conditions in which strontium is fixed on calcite (the object of the Geneva report P/395 - USA - 1958) are more closely studied and the work is extended to five fission products present in the effluents, and to 17 common rocks and minerals. Although as it turns out this fixation is not suitable as a method of treating the S.T.E. effluents (i.e. those from the Effluent Treatment plant at Marcoule), the study shows that all the crystals considered are strongly contaminated by simple contact with the effluents. (author) [French] Les conditions de fixation du strontium sur la calcite (objet du rapport de Geneve P/395 - USA - 1958) sont approfondies et l'etude est etendue aux cinq produits de fission presents dans les effluents et a 17 roches et minerais courants. Bien qu'en definitive cette fixation se revele inutilisable comme procede de traitement d'effluents S.T.E. (Station de Traitement des Effluents, Marcoule), l'etude montre que tous les cristaux consideres se contaminent fortement par simple contact avec les effluents. (auteur)

  19. Artisan fishing and the fishing company in Óbidos, Pará

    Directory of Open Access Journals (Sweden)

    Adriana de Aviz

    2006-08-01

    Full Text Available This work is product of the Project "The time of the plant: the disciplinamento of the workers of the fishing industry (Óbidos-Pará: a comparative study", developed in the years of 2002 and 2003 in the municipality of Óbidos, Pará, objectifying to understand the importance of the time in the disciplinamento of the work in the obidense fishing company. Interviews opened in entrepreneurs had been carried through of fish, controlling, heads of quality control, people in charge of hall and other actors involved in the sector fishing boat and applied half-open questionnaires with laborers and fishing. One used the photographic, recording register and the notebook of notations. The research was carried through in the fishing companies Mundial and Pasquarelli, Colony Z-19 Fishing, in the boats (river Amazon of the artisan fishing and in its residences. As central focus it was looked for to unmask the characteristics of the 'disciplined time' in the sector of improvement of the fishing company, and to detach the joint of the 'natural time' in the process of capture of the fished one. Leaving of these estimated, it was used the 'disciplined time' and the 'natural time' conceived by Thompson (1975.

  20. Assistance to a car heat engine by a self-controlled synchronous machine: engine energy control enhancement and pollutant emission reduction; Assistance d`un moteur thermique d`automobile par une machine synchrone autopilotee: amelioration de la gestion energetique et reduction des polluants du groupe moto-propulseur

    Energy Technology Data Exchange (ETDEWEB)

    Kouadio, L.

    1996-12-12

    A new method for spark-ignition engine control, more especially in idle conditions, has been developed to prevent engine stalling and improve its idling performances in terms of fuel consumption and pollutant emissions: the car synchronous machine, traditionally operating as an alternator, is used in certain phases to provide an external supplementary torque on the engine shaft. Methods are proposed for optimising the synchronous machine operation as a generator and as an engine, then the main engine control parameters are presented and a linear signal model is established around a nominal idling point, which is used for simulations. Experimental results show evident reductions of fuel consumption and a significant robustness improvement in the engine dynamics

  1. Control del parásito Varroa destructor (Acari: Varroidae en colmenas de la abeja Apis mellifera (Hymenoptera: Apidae mediante la aplicación de la técnica de entrampado Control of the parasite Varroa destructor (Acari: Varroidae in honeybee colonies of Apis mellifera (Hymenoptera: Apidae applying brood trap combs

    Directory of Open Access Journals (Sweden)

    Natalia Damiani

    2006-07-01

    Full Text Available La parasitosis causada por el ácaro Varroa destructor (Anderson & Trueman es, actualmente considerada el mayor escollo para el desarrollo de la apicultura. El objetivo del presente trabajo fue evaluar la técnica del entrampamiento de ácaros en panales de cría, como posible método de control de la parasitosis. El trabajo se llevó a cabo en Coronel Vidal, provincia de Buenos Aires. Se trabajó sobre colmenas tipo Langstroth del híbrido regional de Apis mellifera (Linneaus. En cada colmena experimental se procedió a confinar a la reina en panales trampa específicos, con el fin de poder controlar la oviposición. Estos panales, luego de ser operculados por las obreras, fueron llevados al laboratorio donde se desoperculó cada una de las celdas de cría, y se contabilizó el número de ácaros presentes. Esta técnica se aplicó variando el número de panales trampa (1-3 colocados, tanto para los constituidos por celdas de cría de obreras como de zánganos. También, se evaluó el impacto de la aplicación de esta técnica sobre el desarrollo de las colonias, mediante la medición de su productividad. Los resultados indican, que la técnica empleada sólo es efectiva, cuando se aplican tres panales de cría de zánganos de manera consecutiva, alcanzando una efectividad máxima de 84%. Cuando se aplican tres panales de obreras, la técnica mostró niveles de efectividad muy inferiores (14%. En las colonias sobre las que se aplicó esta técnica, la productividad de miel se redujo significativamente, comparada con las colonias control. Esta técnica resulta ideal para ser combinada con otros mecanismos de control, disminuyendo la aplicación de sustancias químicas que puedan contaminar la miel, y la generación de resistencia por parte del ácaro frente a los principios activos utilizados para su control.At present, Varroosis is considered the major problem to beekeeping development. The aim of this work was to evaluate brood tramp combs

  2. Characterization of junctions produced by medium-energy ion implantation in silicon; Caracterisation de jonctions obtenues par implantation d'ions de moyenne energie dans le silicium

    Energy Technology Data Exchange (ETDEWEB)

    Monfret, A [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1970-07-01

    Characteristics of diodes made by implanting 20 keV boron and phosphorus ions into silicon are reviewed. Special features of theses diodes are presented, and correlation with technology is studied. This paper includes three parts: - in the first part, the theory of range distribution is considered for both amorphous and single-crystal targets, - In the second part, a brief description of the experimental conditions is given. - In the third part, the experimental results are presented. The results lead to a schematic model of the component. They also show the influence of cleaning and annealing treatments from which optimized process of fabrication can be determined. In this study, the influence of a two stage annealing process is shown. For phosphorus and boron implants, the first stage is performed at 150 deg. C while the second stage is 450 deg. C for phosphorus and 550 deg. C for boron implants. The implanted diodes are found to exhibit good electrical characteristics. Comparisons with standard diffused diodes are quite favourable. (author) [French] On examine les caracteristiques de diodes obtenues par implantation d'ions bore et phosphore de 20 keV dans le silicium. On met en evidence le comportement particulier de ces diodes et on presente certaines correlations avec la technologie. L'expose comprend trois parties: - la premiere partie est consacree au calcul du profil de dopage en mode canalise ou non. - Dans la deuxieme partie, on decrit l'appareillage et les conditions experimentales d'implantation. - Dans la troisieme partie, on presente les resultats experimentaux. On propose un modele schematique pour expliquer le comportement des tenues en tension des diodes. L'etude des courants de fuite en fonction de la preparation des echantillons et des traitements thermiques permet de determiner des conditions optimales d'elaboration. Au cours de cette etude on met en evidence l'influence de deux stades de recuit: le premier a 150 deg. C pour les implantations de

  3. La syphilis congenitale revelee par une fracture spontanee

    Directory of Open Access Journals (Sweden)

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  4. Results of Preliminary Tests of PAR Bunch Cleaning

    CERN Document Server

    Yao, Chihyuan; Grelick, Arthur; Lumpkin, Alex H; Sereno, Nicholas S

    2005-01-01

    A particle accumulator ring (PAR) is used at the Advanced Photon Source (APS) to collect multiple linac bunches and compress them into a 0.3-ns (rms) single bunch for booster injection. A 9.77-MHz fundamental rf system and a 117.3-MHz harmonic rf system are employed for initial beam capture and bunch length compression. Satellite bunches with very low charge form due to rf phase drifts or beam loading change. These satellites, when injected into the booster and then into the storage ring (SR), cause bunch impurity at three buckets from the target bucket. Storage ring and booster bunch cleaning was tried but proved to be difficult due to the top-up mode of operation in the storage ring and tune drift in the booster synchrotron. Recently we implemented a PAR bunch-cleaning system with tune-modulated harmonic rf knockout. Preliminary tests gave a measured SR bunch purity of better than 10

  5. Avis 6 sur la formation à et par la recherche

    OpenAIRE

    Centre de Coopération Internationale en Recherche Agronomique pour le Développement

    2015-01-01

    La formation à et par la recherche s’appuie sur la démarche scientifique, les savoirs, les connaissances à transmettre, tout autant que l’acquisition de compétences en gestion de projet, de capacités au travail en équipe, d’une ouverture d’esprit qui favorisera la créativité. Elle doit permettre de prendre conscience de la responsabilité endossée par la communauté scientifique vis-à-vis de la société et de l’environnement, mais aussi préparer l’avenir professionnel de celle ou de celui qu...

  6. Evaluation of the Stability After Orthodontic Treatment Using PAR Index

    Directory of Open Access Journals (Sweden)

    Chaitra Ramanathan

    2006-01-01

    Full Text Available The aim of the present study is to establish the results using the scores obtained from the methodology that was applied for assessing the stability after 2 years post orthodontic treatment and stability in a sample of 69 individuals. After applying PAR index to the collected group of patients, a series of scores were obtained, which were then needed to be evaluated further to establish the results. The scores were evaluated using the nomogram. A comparison was done between the post treatment and the 2 years post treatment PAR weighting scores to determine if the results were stable after orthodontic treatment. The majority of the orthodontic patients were treated to a good standard and that the results appeared to be stable.

  7. La prise en charge des troubles de santé mentale par les omnipraticiens du Québec

    Science.gov (United States)

    Fleury, Marie-Josée; Farand, Lambert; Aubé, Denise; Imboua, Armelle

    2012-01-01

    Résumé Objectif Cette recherche vise à documenter la prise en charge des troubles mentaux (TM) par les omnipraticiens. Type d’étude Il s’agit d’une étude mixte intégrant un questionnaire auto-administré et des entrevues qualitatives. La banque de données administratives des actes médicaux de la Régie de l’assurance maladie du Québec a aussi été analysée. Contexte La province de Québec. Participants Un total de 1415 omnipraticiens de différents lieux de pratiques ont été sollicités pour le questionnaire; 970 ont été rejoints. Un sous-groupe de 60 omnipraticiens a été rejoint pour les entrevues. Principaux paramètres à l'étude La prévalence annuelle des consultations reliées à des TM courants (TMC) ou graves (TMG), les pratiques cliniques, les pratiques de collaboration, les facteurs facilitant ou entravant la prise en charge des TM, ainsi que les recommandations pour l’amélioration du système de soins. Résultats Le taux de réponse a été de 41% (n = 398 omnipraticiens) pour le questionnaire et de 63% (n = 60) pour les entrevues. Environ 25 % des visites chez les omnipraticiens sont associées à des TM. Presque tous les omnipraticiens prennent en charge des TMC et se sentent compétents pour le faire, à l’inverse de la situation retrouvée pour les TMG. Près de 20 % des TMC sont référés (principalement à des intervenants psychosociaux), alors que près de 75 % des TMG sont référés (surtout en psychiatrie et à l’urgence). Plus de 50 % des omnipraticiens affirment n’entretenir aucun contact avec l’une ou l’autre des ressources de santé mentale. Plusieurs facteurs influencent la prise en charge des TM: les profils des patients (complexité des TM, troubles concomitants); les caractéristiques des omnipraticiens (réseau informel, formation); la culture professionnelle (travail en silo, mécanismes cliniques formalisés); le milieu institutionnel (multidisciplinarité, salariat); l’organisation des

  8. La parálisis cerebral en el contexto escolar /

    OpenAIRE

    González Vara, Azucena

    2012-01-01

    Se analiza el concepto de parálisis cerebral, los diferentes tipos y sus características. También las adaptaciones que se deben realizar a nivel de centro, de aula, y a nivel individual para estos alumnos, conocer los diferentes sistemas alternativos y aumentativos de comunicación y aplicar las ayudas técnicas que precisa este alumnado

  9. Tuberculose lymphonodale cervicale chez les enfants vaccines par ...

    African Journals Online (AJOL)

    La tuberculose ganglionnaire cervicale est une localisation extrapulmonaire relativement fréquente chez l'enfant. Elle pose essentiellement des difficultés de prévention. L'objectif de ce travail est d'étudier les particularités diagnostiques et thérapeutiques chez des enfants vaccinés par le BCG. Matériel et méthodes: Nôtre ...

  10. Traitement De La Peripneumonie Contagieuse Bovine Par L ...

    African Journals Online (AJOL)

    Traitement De La Peripneumonie Contagieuse Bovine Par L'oxyteTracycline Longe Action Et Transmission Experimentale de la Maladie A Partir de Bovins Traites. ... Tous les 14 animaux ont séroconverti et l'analyse post-mortem a montré la présence des lésions chroniques dont des séquestres pulmonaires chez 4 d'entre ...

  11. Adoption d'innovations agricoles par le truchement de services ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'agriculture est le fer de lance de nombreuses économies en développement, mais la capacité des petits agriculteurs privés de ressources à adopter des innovations agricoles est freinée par le manque d'accès à des services financiers adéquats. Des experts internationaux estiment qu'il existe un manque à gagner ...

  12. Candido: Uma Leitura Paródica de Candide

    Directory of Open Access Journals (Sweden)

    Maria Gloria Cusumano Mazzi

    2010-12-01

    Full Text Available O presente artigo estuda a leitura paródica que Leonardo Sciascia (1921-1989 faz de Voltaire (1694-1778 mediante o cotejo das obras: o hipertexto Candido ovvero Un sogno fatto in Sicilia (1977 e o hipotexto Candide ou l’optimisme (1759. Apresenta ainda outra possibilidade de leitura, ou seja, Candido como metáfora da própria intertextualidade.

  13. Solution volumes finis polynomiale par morceaux pour les ...

    African Journals Online (AJOL)

    Nous présentons dans ce papier un concept de solution volumes finis continue pour des problèmes de diffusion-convection avec des données régulières. Nous comparons dans certains cas particuliers la solution proposée avec la solution volumes finis classiques (qui est une fonction constante par morceaux) et la ...

  14. Parâmetros genéticos para a produção de leite de controles individuais de vacas da raça Gir estimados com modelos de repetibilidade e regressão aleatória Estimation of genetic parameters for test day milk records of first lactation Gyr cows using repeatability and random regression animal models

    Directory of Open Access Journals (Sweden)

    Claudio Napolis Costa

    2005-10-01

    Full Text Available Registros individuais perfazendo 8.183 controles de produção de leite (PLC de 1.273 primeiras lactações de vacas da raça Gir de rebanhos supervisionados pela ABCZ no período 1994/2000 foram utilizados para se estimar componentes de variância e parâmetros genéticos para PLC usando-se REML. Foram comparados um modelo de repetibilidade e modelos de regressão aleatória ajustados com as funções logarítmica (Ali & Schaeffer, 1987, exponencial (Wilmink, 1987 e polinômios ortogonais de Legendre (LP de ordem 3 a 5, sob as pressuposições de homogeneidade e heterogeneidade de variância residual, definidas respectivamente por uma (ME=1 ou quatro classes de medidas de erro temporário (ME=4 ao longo do período de lactação. Também ajustou-se a produção de leite acumulada na lactação (P305 utilizando-se um modelo animal cuja estimativa de heritabilidade foi 0,22. As estimativas de heritabilidade e repetibilidade para a PLC foram 0,27 e 0,76, respectivamente. As estimativas de heritabilidade com a FAS e a FW alcançaram respectivamente 0,59 e 0,74 ao início da lactação e decresceram para valores próximos de 0,20 ao final do período. Exceto para o LP de quinta ordem com ME=1, as estimativas de heritabilidade diminuíram de 0,70 no início para 0,30 no final da lactação. Menores estimativas de VR foram obtidas para a FAS do que para a FW sob ambas as pressuposições de homogeneidade e heterogeneidade de variância. Em todos os estádios da lactação, as estimativas de VR diminuíram com o aumento da ordem do LP e dependeram da pressuposição sobre o ME. As estimativas das variâncias genética e de ambiente permanente não apresentaram nenhuma tendência com o aumento da ordem do LP e não se observaram diferenças significativas para tais estimativas sob a pressuposição de heterogeneidade de VR ao longo da lactação. Maiores valores de correlação genética entre as PLC foram obtidos com a FW, que também apresentou maior

  15. Improvement of the local control of spinal chordomas treated by surgery and targeted irradiation (CyberKnife{sup R}) on hypoxic cells marked with {sup 18}F-FMiso; Amelioration du controle local des chordomes du rachis traites par chirurgie et une irradiation (CyberKnife{sup R}) ciblee sur les cellules hypoxiques marquees au {sup 18}F-FMiso

    Energy Technology Data Exchange (ETDEWEB)

    Mammar, H.; Kerrou, K.; Bondiau, P.Y.; Angellier, G.; Thariat, J.; Benezery, K.; Heroult, J.; Leysalle, A.; Gerard, J.P. [Centre Antoine-Lacassagne, Nice (France); Talbot, J.N. [Service de medecine nucleaire, Hopital Tenon, AP-HP, Paris (France)

    2011-10-15

    The authors report and comment the treatment of two women suffering from a recurring cervical spine chordoma. Each patient had a first PET (positron emission tomography) with {sup 18}F-fluorodeoxyglucose to assess the hyper-metabolic component and PET with {sup 18}F-FMiso to quantify the hypoxic component within the lesion. This last PET allows a non-invasive quantification of the hypoxic component which is potentially radio-resistant in cervical spine chordomas. It also allows an intelligent dose increase to improve the local control rate. Short communication

  16. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Silva, Jose Alberto Alves da

    2009-01-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH 2 , respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  17. Bromine-82 Labelling of Human Serum Albumin, Insulin and Fibrinogen by Electrochemical Means; Marquage au Brome-82 de la Serum-Albumine Humaine, de l'Insuline et du Fibrinogene par Voie Electrochimique; ЭЛЕКТРОХИМИЧЕСКОЕ МЕЧЕНИЕ ИЗОТОПОМ БРОМА-82 АЛЬБУМИНА ЧЕЛОВЕЧЕСКОЙ СЫВОРОТКИ, ФИБРИНОГЕНА И ИНСУЛИНА; Marcacion de Sueroalbumina Humana, de Insulina y de Fibrinogeno con Bromo-82 por Via Electroquimica

    Energy Technology Data Exchange (ETDEWEB)

    Rosa, U.; Scassellati, G. A.; Pennisi, G. [Centre de Recherches Nucleaires Sorin, Saluggia (Italy)

    1963-03-15

    The authors describe results obtained with a method using bromine-82 to label human serum albumin, fibrinogen and insulin, three organic substances of special importance in diagnostics and biological research. The method involves electrolytic bromination in an aqueous solution; this is performed in an electrolysis cell, whose anodic zone containing the substance to be labelled is partitioned from the cathodic zone by a dialysis membrane. For each of the three substances mentioned, the degree of bromination produced by a direct current (200, 200, 300 x 10{sup -6} A) was studied as a function of anode potential in 10{sup -3} and 10{sup -4} M solutions of NH{sub 4}Br, the amount of bromine-labelled substance formed being checked by radio electrophoresis for various anodic potential values differing from each other by 50 mV. By immuno- electrophoresis it was ascertained that denaturation of albumin and fibrinogen only starts at anodic potential values for which the degree of labelling is already very high as compared with that yielded by chemical methods of labelling. The method here described has the advantage of rapid execution and is well suited to remote handling in a shielded zone. (author) [French] Les auteurs exposent les resultats obtenus par une methode de marquage au brome- 82 de trois substances organiques particulierement interessantes pour l'usage diagnostique et pour la recherche biologique: albumine de serum humain, fibrinogene et insuline. La methode comporte une bromuration electrolytique en solution aqueuse qu'on execute dans une cellule d'electrolyse dont la zone anodique contient la substance a marquer et est cloisonnee par rapport a la zone cathodique par une membrane a dialyse. Pour chacune des trois substances susmentionnees, on a etudie le rendement de bromuration a courant constant (100, 200, 300 * 10{sup -6} A) en fonction du potentiel anodique, en solution 10{sup -3} et 10{sup -4} M de NH{sub 4}Br, en controlant par radioelectrophorese la

  18. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob

    2012-01-01

    the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  19. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA......-conjugated version (NOTA-AE105) for development of the first (18)F-labeled uPAR positron-emission-tomography PET ligand using the Al(18)F radiolabeling method. In this study, the potential of (18)F-AlF-NOTA-AE105 to specifically target uPAR-positive prostate tumors was investigated....

  20. Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

    DEFF Research Database (Denmark)

    Rasch, M.G.; Lund, I.K.; Hoyer-Hansen, G.

    2008-01-01

    identified in tissue and body fluids. It is well-established, that the total amount of all uPAR forms is a strong prognostic marker in different types of cancer. Using immunoassays, measuring the individual uPAR forms, has revealed that the cleaved uPAR forms are even stronger prognostic markers and have...... diagnostic utility. This review will focus on the mechanism of uPAR cleavage and the functional consequences, as well as the clinical applicability of cleaved uPAR forms Udgivelsesdato: 2008...

  1. The relationship between levels of plasma-soluble urokinase plasminogen activator receptor (suPAR) and presence of migraine attack and aura.

    Science.gov (United States)

    Yılmaz, Nigar; Yılmaz, Mustafa; Sirin, Burcu; Yılmaztekin, Sureyya; Kutlu, Gülnihal

    2017-10-01

    Migraine is one of the most common types of pain associated with sterile inflammatory conditions. Soluble urokinase plasminogen activator receptor (suPAR) is a potential novel inflammatory marker. We aim to determine the association between serum values of suPAR, procalcitonin, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP) and migraine disease characteristics. The study involved a total of 60 migraine patients (33 patients in the interictal period, 27 patients in the attack period) and 30 healthy individuals. The serum values of suPAR were found to be significantly higher in migraine patients in the attack period than in migraine patients in the interictal period, and in healthy individuals (p migraine with aura patients than in migraine without aura patients. When we subdivided migraine patients according to frequency of attack (attacks/month), significant differences were found between the suPAR and procalcitonin levels (measured during the attack period) of those in the frequent-attack group (4-5 or more) versus those in the less frequent attack group (less than 4). Serum levels of procalcitonin were shown to be significantly higher in migraine patients during the attack period compared with migraine patients in the interictal period and in control subjects (p = .001 for both). Significant differences were found between plasma levels of fibrinogen in migraine patients versus control subjects (p migraine patients versus the control group. These findings may show that presenting a high level of suPAR in migraine patients with attack and aura results to predisposition to occurring on the symptoms and that high levels of suPAR, procalcitonin and fibrinogen in patients with migraine result in neurogenic inflammation during migraine headaches.

  2. Dynamic Filament Formation by a Divergent Bacterial Actin-Like ParM Protein.

    Directory of Open Access Journals (Sweden)

    Anthony J Brzoska

    Full Text Available Actin-like proteins (Alps are a diverse family of proteins whose genes are abundant in the chromosomes and mobile genetic elements of many bacteria. The low-copy-number staphylococcal multiresistance plasmid pSK41 encodes ParM, an Alp involved in efficient plasmid partitioning. pSK41 ParM has previously been shown to form filaments in vitro that are structurally dissimilar to those formed by other bacterial Alps. The mechanistic implications of these differences are not known. In order to gain insights into the properties and behavior of the pSK41 ParM Alp in vivo, we reconstituted the parMRC system in the ectopic rod-shaped host, E. coli, which is larger and more genetically amenable than the native host, Staphylococcus aureus. Fluorescence microscopy showed a functional fusion protein, ParM-YFP, formed straight filaments in vivo when expressed in isolation. Strikingly, however, in the presence of ParR and parC, ParM-YFP adopted a dramatically different structure, instead forming axial curved filaments. Time-lapse imaging and selective photobleaching experiments revealed that, in the presence of all components of the parMRC system, ParM-YFP filaments were dynamic in nature. Finally, molecular dissection of the parMRC operon revealed that all components of the system are essential for the generation of dynamic filaments.

  3. Proteinase-Activated Receptor 1 (PAR1 regulates leukemic stem cell functions.

    Directory of Open Access Journals (Sweden)

    Nicole Bäumer

    Full Text Available External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  4. Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

    Science.gov (United States)

    Bäumer, Nicole; Krause, Annika; Köhler, Gabriele; Lettermann, Stephanie; Evers, Georg; Hascher, Antje; Bäumer, Sebastian; Berdel, Wolfgang E; Müller-Tidow, Carsten; Tickenbrock, Lara

    2014-01-01

    External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  5. Control of radioactive wastes and coupling of neutron/gamma measurements: use of radiative capture for the correction of matrix effects that penalize the fissile mass measurement by active neutron interrogation; Controle des dechets radioactifs et couplage de mesures neutron/gamma: exploitation de la capture radiative pour corriger les effets de matrice penalisant la mesure de la masse fissile par interrogation neutronique active

    Energy Technology Data Exchange (ETDEWEB)

    Loche, F

    2006-10-15

    In the framework of radioactive waste drums control, difficulties arise in the nondestructive measurement of fissile mass ({sup 235}U, {sup 239}Pu..) by Active Neutron Interrogation (ANI), when dealing with matrices containing materials (Cl, H...) influencing the neutron flux. The idea is to use the neutron capture reaction (n,{gamma}) to determine the matrix composition to adjust the ANI calibration coefficient value. This study, dealing with 118 litres, homogeneous drums of density less than 0,4 and composed of chlorinated and/or hydrogenated materials, leads to build abacus linking the {gamma} ray peak areas to the ANI calibration coefficient. Validation assays of these abacus show a very good agreement between the corrected and true fissile masses for hydrogenated matrices (max. relative standard deviation: 23 %) and quite good for chlorinated and hydrogenated matrices (58 %). The developed correction method improves the measured values. It may be extended to 0,45 density, heterogeneous drums. (author)

  6. Incremento de la competencia lingüística en dos sujetos con parálisis cerebral mediante el dispositivo Makey-Makey

    OpenAIRE

    Calleja-Reina, Marina; Luque-Liñán, María Luisa; Liranza Grajales, Ana Isabel

    2015-01-01

    Incremento de la competencia lingüística en dos sujetos con Parálisis Cerebral mediante el dispositivo Makey-Makey. Un estudio de caso Las personas con PC presentan un riesgo considerable de sufrir problemas de comunicación. Estos problemas de comunicación pueden surgir a consecuencia de déficits en el control motor del habla, en la cognición, en el lenguaje, en la percepción/sensación o una combinación de todos ellos (Hustad & Miles, 2010). En este trabajo se muestran dos casos de Parális...

  7. Ambroise Paré (1510-1590) and His Innovative Work on the Treatment of War Injuries.

    Science.gov (United States)

    Markatos, Konstantinos; Tzivra, Anna; Tsoutsos, Spyridon; Tsourouflis, Gerasimos; Karamanou, Marianna; Androutsos, Georgios

    2018-04-01

    The purpose of this study is to summarize the innovations of Ambroise Paré (1510-1590) on the treatment of war wounds and improving amputation technique through ligature in arteries and veins. Ambroise Paré debunked the widely accepted idea that gun powder was poisonous for wounds. He also minimized the use of cautery of wounds by his dressing methods and the application of ligature during amputations. All these innovative rationales revolutionized the practice of war surgery during the Renaissance and paved the way for the introduction of modern surgery. Nevertheless, although his wound dressing innovations became widely accepted, the same did not happen with ligature and amputation; those techniques could become widely applicable if one could somehow control bleeding until the blood vessels had been tied. This became possible much later in the 18th century when Jean Louis Petit invented the first useful and efficient tourniquet.

  8. Open Issues in Supervisory Control of Hybrid Electric Vehicles: A Unified Approach Using Optimal Control Methods Questions ouvertes sur la supervision énergétique des véhicules hybrides électriques : une approche unifiée par la théorie de la commande optimale

    Directory of Open Access Journals (Sweden)

    Serrao L.

    2013-03-01

    Full Text Available Energy management of hybrid propulsion systems is considered, presenting new issues that extend the energy management role beyond the standard torque splitting to maximize system efficiency. The new issues include additional optimization criteria, constraints and relevant dynamics to deal with. New optimization criteria in addition the sole fuel consumption minimization include engine-out pollutant emissions and battery aging. State constraints are modified to account for plug-in hybrid vehicles. Moreover, specific supervisory control problems are recognized to need additional state variables. The latter comprise: engine and catalyst temperature to deal with engine warm-up effects on fuel consumption and after-catalyst emissions; thermal dynamics of heat recovery systems (Rankine or Thermo-Electric Generators, TEGs; and battery temperature, which influences battery performance and aging. It is shown that all these control problems can be treated in an unified fashion by extending the well-known ECMS (Equivalent Consumption Minimization Strategy, which is an implementation of Pontryagin Minimum Principle (PMP as formulated by optimal control theory. Extended definitions of the Hamiltonian function and Lagrange multipliers are introduced. Optimization runs performed off line are reported. Results show the benefits of the proposed unified approach and enlighten some first online implementation issues. Cet article a pour objet la gestion optimale de l’énergie pour un système de propulsion hybride. Le problème traditionnel de répartition de la puissance est modifié avec des nouveaux objectifs d’optimisation et des nouvelles contraintes. Les nouveaux objectifs d’optimisation incluent les émissions de polluants et le vieillissement de la batterie. Les contraintes sont modifiées pour prendre en compte des batteries à recharge externe (hybrides plug-in. De plus, des problèmes spécifiques sont traités avec une modélisation plus d

  9. Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate

    Energy Technology Data Exchange (ETDEWEB)

    Vorhagen, Susanne; Niessen, Carien M., E-mail: carien.niessen@uni-koeln.de

    2014-11-01

    Oriented cell division is a key regulator of tissue architecture and crucial for morphogenesis and homeostasis. Balanced regulation of proliferation and differentiation is an essential property of tissues not only to drive morphogenesis but also to maintain and restore homeostasis. In many tissues orientation of cell division is coupled to the regulation of differentiation producing daughters with similar (symmetric cell division, SCD) or differential fate (asymmetric cell division, ACD). This allows the organism to generate cell lineage diversity from a small pool of stem and progenitor cells. Division orientation and/or the ratio of ACD/SCD need to be tightly controlled. Loss of orientation or an altered ratio can promote overgrowth, alter tissue architecture and induce aberrant differentiation, and have been linked to morphogenetic diseases, cancer and aging. A key requirement for oriented division is the presence of a polarity axis, which can be established through cell intrinsic and/or extrinsic signals. Polarity proteins translate such internal and external cues to drive polarization. In this review we will focus on the role of the polarity complex aPKC/Par3/Par6 in the regulation of division orientation and cell fate in different mammalian epithelia. We will compare the conserved function of this complex in mitotic spindle orientation and distribution of cell fate determinants and highlight common and differential mechanisms in which this complex is used by tissues to adapt division orientation and cell fate to the specific properties of the epithelium.

  10. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  11. ParABS Systems of the Four Replicons of Burkholderia cenocepacia: New Chromosome Centromeres Confer Partition Specificity†

    Science.gov (United States)

    Dubarry, Nelly; Pasta, Franck; Lane, David

    2006-01-01

    Most bacterial chromosomes carry an analogue of the parABS systems that govern plasmid partition, but their role in chromosome partition is ambiguous. parABS systems might be particularly important for orderly segregation of multipartite genomes, where their role may thus be easier to evaluate. We have characterized parABS systems in Burkholderia cenocepacia, whose genome comprises three chromosomes and one low-copy-number plasmid. A single parAB locus and a set of ParB-binding (parS) centromere sites are located near the origin of each replicon. ParA and ParB of the longest chromosome are phylogenetically similar to analogues in other multichromosome and monochromosome bacteria but are distinct from those of smaller chromosomes. The latter form subgroups that correspond to the taxa of their hosts, indicating evolution from plasmids. The parS sites on the smaller chromosomes and the plasmid are similar to the “universal” parS of the main chromosome but with a sequence specific to their replicon. In an Escherichia coli plasmid stabilization test, each parAB exhibits partition activity only with the parS of its own replicon. Hence, parABS function is based on the independent partition of individual chromosomes rather than on a single communal system or network of interacting systems. Stabilization by the smaller chromosome and plasmid systems was enhanced by mutation of parS sites and a promoter internal to their parAB operons, suggesting autoregulatory mechanisms. The small chromosome ParBs were found to silence transcription, a property relevant to autoregulation. PMID:16452432

  12. Preparation of Uranium Dioxide by Electrochemical Reduction in Ammonium Carbonate Solutions and Subsequent Precipitation; Preparation de bioxyde d'uranium par reduction electrochimique dans des solutions de carbonate d'ammonium et precipitation; Prigotovlenie dvuokisi urana metodom ehlektrokhimicheskogo vosstanovleniya v rastvore karbonata ammoniya s posleduyushchim osazhdeniem; Preparacion de dioxido de uranio por reduccion electroquimica en soluciones de carbonato amonico u precipitacion subsiguiente

    Energy Technology Data Exchange (ETDEWEB)

    Pravdic, V.; Branica, M.; Pucar, Z. [Department of Physical Chemistry, Rudjer Boskovic Institute, Zagreb, Yugoslavia (Serbia)

    1963-11-15

    'il est possible d'obtenir, avec un bon rendement, de l'uranium (IV) en solution carbonatee. Il suffit de chauffer la solution pour faire precipiter l'hydroxyde d'uranium (IV). Afin d'obtenir des matieres en quantites plus importantes, pour les essais technologiques, les auteurs ont fait une experience en plus grand. Ils ont construit une cellule d'electrolyse en chlorure de polyvynile dur, avec une cathode de mercure (environ 2,5dm{sup 2} ) et des anodes de platine. Le catholyte etait separe de l'anolyte par des membranes echangeuses de cations. Le catholyte circulait entre deux reservoirs de 50 1 et passait sur la cathode de mercure soumise a une agitation energique. Le potentiel du mercure etait controle par reference a une electrode temoin de Ag/AgCl/KCl (sat.), et maintenu constant a -1,5 V. Le rendement du courant etait d'environ 90% et la consommation d'energie, pour l'operation de reduction, d'environ 0,8 kWh/kg de bioxyde d'uranium. A la fin de l'electrolyse, on a provoque la precipitation par simple chauffage de la solution (limpide, d'un vert fonce) jusqu'a une temperature de 70 deg. C, dans un autre recipient tout en verre, de 60 1. Sur 50 1 de solution catholytique, on a obtenu 1 kg de produit centrifuge (contenant environ 20% d'eau). L'analyse coulombmetrique du rapport O/U a toujours donne des resultats compris entre 2,04 et 2,09. La methode decrite permet de faire precipiter l'hydroxyde d'uranium (IV) seul et le rapport O/U dans le precipite est independant du degre atteint par la reduction. En analysant la poudre par diffraction des rayons X, on a identifie le produit comme etant la phase alpha du bioxyde d'uranium. On procede maintenant a des experiences de frittage et a l'etude des caracteristiques du bioxyde d'uranium ainsi obtenu pour determiner s'il peut servir a la fabrication de combustible nucleaire ceramique. (author) [Spanish] Se intento ampliar la escala del proceso con el fin de obtener las cantidades de material que requieren los ensayos

  13. Serum suPAR in patients with FSGS: trash or treasure?

    Science.gov (United States)

    Maas, Rutger J H; Deegens, Jeroen K J; Wetzels, Jack F M

    2013-07-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both overexpression of uPAR on podocytes and the administration of suPAR cause proteinuria in mice. The common pathogenic mechanism involves the activation of podocyte β3-integrin. Increased activation of β3-integrin is also observed in patients with focal and segmental glomerulosclerosis (FSGS). These observations form the basis for the hypothesis that suPAR may be the circulating factor causing FSGS. A recent study fosters this idea by demonstrating increased suPAR levels in the serum of patients with FSGS and reporting an association with recurrence after transplantation and response to plasmapheresis. However, this study was heavily biased, and subsequent studies have given conflicting results. Although the experimental work is very suggestive, at present there is no proof that any known human suPAR fragment causes FSGS in humans. We therefore suggest that the measurement of suPAR using currently available assays has absolutely no value at the present time in decision-making in routine clinical practice.

  14. Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

    Science.gov (United States)

    Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

    2015-07-02

    Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

  15. Convention on the establishment of a security control in the field of nuclear energy. Protocol on the tribunal established by the convention on the establishment of a security control in the field of nuclear energy; Convention sur l'etablissement d'un controle de securite dans le domaine de l'energie nucleaire. Protocole relatif au tribunal cree par la Convention sur l'etablissement d'un controle de securite dans le domaine de l'energie nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1957-12-20

    The governments of Germany, Austria, Belgium, Denmark, France, Greece, Ireland, Iceland, Italy, Luxembourg, Norway, Netherlands, Portugal, United Kingdom, Sweden, Switzerland and Turkey, having resolved to promote the development of the production and uses of nuclear energy in the Member countries of the Organisation for European Economic Co-operation between these countries and the harmonisation of national measures; considering that the joint action undertaken to this end in the Organisation is intended to develop the European nuclear industry for purely peaceful ends and must not further any military purpose; considering that at its meeting of' 18 July, 1956, the Council of the Organisation decided to establish to this effect an international security control; considering that by a Decision dated this day the Council has established, within the Organisation, a European Nuclear Energy Agency with the task of pursuing the joint action undertaken; have agreed the present convention. The governments party to the Convention, desirous of determining in accordance with Article 12 of the Convention the organisation of the Tribunal established by the said Article and the status of its judges; have agreed upon the provisions which are annexed to the Convention.

  16. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

    International Nuclear Information System (INIS)

    Boosen, Meike; Vetterkind, Susanne; Koplin, Ansgar; Illenberger, Susanne; Preuss, Ute

    2005-01-01

    Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis

  17. Bacterial mitosis: Partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, G.; Gerdes, Kenn

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells......A-GFP oscillated in spiral-shaped structures. Amino acid substitutions in ParA simultaneously abolished ParA spiral formation, oscillation and either plasmid localization or plasmid separation at mid-cell. Therefore, our results suggest that ParA spirals position plasmids at the middle of the bacterial nucleoid...

  18. Envenimation mortelle par morsure de serpent chez une femme ...

    African Journals Online (AJOL)

    Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l'évolution a été marquée par l'installation d'un oedème cervico-facial nécessitant une trachéotomie en urgence, et une mort foetale in utero avec troubles de l'hémostase responsable du décès maternel dans un ...

  19. Analysis of clinical features and visual outcomes of pars planitis.

    Science.gov (United States)

    Berker, Nilufer; Sen, Emine; Elgin, Ufuk; Atilgan, Cemile Ucgul; Dursun, Erdem; Yilmazbas, Pelin

    2018-04-01

    To evaluate the demographic characteristics, clinical features, treatment and outcomes of patients with pars planitis in a tertiary referral center in Turkey. Medical records of patients with pars planitis were retrospectively reviewed. The data including demographic and ocular features and treatment outcomes were recorded. The distribution of clinical findings and complications were evaluated according to age and gender groups. The changes in final BCVA compared to the initial BCVA were noted. Statistical analysis was performed using SPSS software (Version 18.0, SPSS Inc., Chicago, USA). Twenty-seven patients (54 eyes) were included in this study. 16 patients were male (59.3%), and 11 were female (40.7%). Mean age at diagnosis was 12.84 ± 8.26 (range 4-36) years. Mean follow-up period was 61.3 ± 52.15 (range 9-172) months. Mean BCVA was 0.58 ± 0.36 (range 0.03-1.00) (0.40 ± 0.45 logMAR) at presentation, and 0.81 ± 0.28 (range 0.10-1.00) (0.14 ± 0.27 logMAR) at final visit (P = 0.001). Vitreous inflammation (100%), vitreous haze (92.6%), snowballs (74.1%), snowbanks (66.7%), anterior chamber cells (66.7%) and peripheral retinal vascular sheathing (48.1%) were the most common presentations. Ocular complications included vitreous condensation (51.9%), cystoid macular edema (22.2%), cataract (18.5%), inferior peripheral retinal detachment (11.1%), glaucoma (5.6%) and vitreous hemorrhage (3.7%). Treatments included topical, periocular, intravitreal and systemic corticosteroids, immunosuppressives, peripheral laser photocoagulation and pars plana vitrectomy when needed. Pars planitis is an idiopathic chronic intermediate uveitis mostly affecting children and adolescents. In spite of its chronic nature with high potential of causing ocular complications, adequate treatment and close follow-up lead to favorable visual outcomes.

  20. Cartographie par carroyage et précision spatiale

    Directory of Open Access Journals (Sweden)

    Patrice LANGLOIS

    1998-03-01

    Full Text Available Dans le cadre d'une cartographie par carroyage, on étudie la désagrégation de variables zonales, en revenant sur l'hypothèse de l'équirépartition spatiale des populations. L'objectif est d'approcher des règles différenciées de désagrégation des variables en fusionnant des plans d'information de nature morphologique, topologique et environnementale.

  1. Gas-flow detector for uranium contamination on finned-can surface of a reactor fuel; Detecteur a courant gazeux pour deceler la contamination en uranium des nervures des gaines de combustible nucleaire; Gazopotochnyj detektor zagryazneniya uranom rebristoj poverkhnosti obolochki reaktornykh teplovydelyayushchikh ehlementov; Detector de flujo gaseoso para medir la contaminacion de uranio en la superficie de la vaina de aletas de los elementos combustibles para reactores

    Energy Technology Data Exchange (ETDEWEB)

    Miwa, H; Shiojiri, T; Maeda, Y [Kobe Kogyo Corporation, Okubo, Akashi, Hyogo (Japan)

    1962-04-15

    Calder Hall-type reactor-fuel and all JRR-3 fuels are to be inspected by this counter. (author) [French] Le detecteur a courant gazeux presente par les auteurs est un compteur proportionnel a grille, specialement concu pour deceler la contamination en uranium des nervures des gaines de combustible nucleaire. Un compteur proportionnel classique, compose seulement d'une cathode et d'un collecteur, n'est guere capable de deceler les particules alpha emises par l'uranium contaminant une surface rugueuse telle que les nervures d'une gaine de combustible nucleaire, par suite du manque d'uniformite du champ electrique pres de la surface. C'est pourquoi les auteurs ont construit un compteur proportionnel a grille. Cet appareil, de forme cylindrique, comprend le combustible, une grille, des collecteurs et une cathode, tous les elements etant disposes suivant le meme axe. Le combustible est place au centre de la grille a laquelle on applique une tension negative. L'espace entre le combustible et la grille sert de collecteur d'ions. La grille, faite de fils paralleles minces en tungstene, disposes suivant un cylindre autour du combustible, est reliee a la terre. Les collecteurs sont constitues de 16 minces fils de tungstene disposes de la meme maniere que la grille, mais chaque fil est isole electriquement des autres. Tous les collecteurs sont interconnectes par des resistances de 5 x 10{sup 4} ohms et relies au positif de la haute tension par une resistance. L'espace entre la grille, les collecteurs et la cathode sert a la multiplication du gaz, tout comme dans un compteur proportionnel classique. Chaque resistance de 5 x 10{sup 4} ohms isole la capacite parasite de chaque collecteur. La sortie du detecteur est couplee a un amplificateur a faible impedance d'entree. La faible impedance d'entree diminue aussi l'influence facheuse de la capacite parasite du circuit d'entree. Il en resulte un rapport favorable signal/bruit de fond, ce qui permet une bonne detection des particules

  2. Preparation and properties of carbonaceous products prepared by the cracking of natural gas; Fabrication et proprietes de corps carbones prepares par craquage de gaz naturel

    Energy Technology Data Exchange (ETDEWEB)

    Blum, P L; Bochirol, L; Rappeneau, J; Cornuault, P; Blanchard, R; Moreau, C [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1964-07-01

    . Plusieurs voies ont ete etudiees: 1 - En utilisant comme supports des graphites industriels de qualite courante (densite voisine de 1,50) on obtient des corps d'une densite proche de 1,80. Leur porosite ouverte (6 a 7 pour cent) est inferieure a celle des graphites traditionnels, et plusieurs de leurs proprietes sensiblement egales ou superieures a celles resultant habituellement d'une double inpregnation au brai. 2 - L'utilisation comme supports de demi-produits ('cuits') cycle traditionnel de fabrication des graphites ne conduit pas a des resultats satisfaisants. On en donne les raisons principales. 3 - Un procede nouveau, dit 'BB5', a ete mis au point. Il part, directement des matieres de corps pulverulentes (coke de petrole ou graphite) mises en forme au moyen d'un liant dispersable dans l'eau. Les supports ainsi constitues permettent, du fait de leur structure poreuse, de tirer le meilleur parti de la densification par craquage, en dessous de 1000 deg. C: du gaz naturel. Les produits obtenus, composes a parts a peu pres egales de la matiere de corps et de pyrocarbone, peuvent avoir des densites depassant 1,90. Leur porosite ouverte, tres faible, peut etre rendue pratiquement nulle, leur impermeabilite etant alors excellente (k = 10{sup -8} cm{sup 2}sec{sup -1}). Ils sont egalement remarquables par leur resistance elevee a la compression, qui peut se situer entre 15 et 20 kg/mm{sup 2} pour les versions ne subissant pas un traitement final de graphitation. On indique quelques exemples d'applications possibles, dans le domaine, nucleaire, des materiaux ainsi prepares. (auteurs)

  3. Radio Column Chromatographic Assay of H{sup 3}-Labelled Substances; Analyse par radiochromatographie en colonne, de substances marquees par le tritium; Radiokhromatograficheskoe ispytanie mechennykh tritiem veshchestv na kolonke; Analisis por radiocromatografia en columna de sustancias marcadas con {sup 3}H

    Energy Technology Data Exchange (ETDEWEB)

    Scharpenseel, H W; Menke, K H [Institute of Soil Science and Institute of Animal Husbandry, Bonn University, Bonn (Germany)

    1962-01-15

    between the analyser- and monitor-phototubes. In order to ensure a laminar flow and constantly mixed volume ratio, dose-pumps are lised for the supply of buffer on the column and of the 30-fold volume of toluene/ethanol. The counting efficiency for H{sup 3} averages 2.5-4% for'coils spreading over the whole diameter of the phototubes. 3. The aqeous column effluent is led through an anthracene-filled glass tube and the H{sup 3} counted with close to l{sup o}/o efficiency. (author) [French] Dans la majorite des cas, les recherches radiochromatographique s combinees portant sur des substances marquees par {sup 3}H font partie integrante des experiences biochimiques utilisant des composes trities. Avec un ensemble comprenant un compteur a balayage continu sans fenetre, le comptage du tritium par radiochromatographi e sur papier est d'un rendement de 0,5 a 1,5%, qui depend dans une large mesure de l'epaisseur du papier et de l'autoabsorption dans le compose marque. La radiochromatographie en phase gazeuse des composes trities ne presente pas davantage de difficultes serieuses. On utilise avec succes un ensemble de chromatographic en phase gazeuse comportant une chambre d'ionisation a courant et un electrometre a lame vibrante - concu par K. E. Wilzbach et P. Riesz et perfectionne par H. Dutton, L. Mason et L. Blair. Grace a l'emploi de ''Teflon'' et de caoutchouc de silicones pour les elements isolants de la chambre d'ionisation, cet ensemble peut fonctionner a des temperatures voisines de 300{sup o}C. Avec le tritium, la radiochromatographi e en colonne donne des resultats mediocres, si le liquide sortant de la colonne se repand en une couche mince et passe lentement sous un compteur a balayage continu sans fenetre ou un compteur a scintillations, alors que le meme procede a donne d'excellente resultats avec le carbone-14. Aussi est-il probable que l'on adoptera la spectrometrie a scintillations en phase liquide. Elle comporte essentiellement deux procedes differents, que les

  4. Statistical Control of Measurement Quality; Controle Statistique de la Qualite de la Mesure; Statisticheskim kontrol' kachestva izmerenij; Control Estadistico de la Calidad de las Mediciones

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, C. A. [Battelle Memorial Institute, Richland, WA (United States)

    1966-02-15

    de ces matieres dependent beaucoup de la valeur des donnees quantitatives sur lesquelles ils sont fondes. Il importe donc de connaitre le degre de precision des methodes de mesure employees, afin de determiner les exigences en matiere de donnees et d'evaluer les resultats obtenus. Toute methode d'analyse doit etre 1. relativement exempte d'erreur systematique, 2. reproductible, autrement dit precise. On dispose de nombreuses methodes statistiques pour evaluer et controler la reproductibilite des resultats des analyses. On a mis au point des moyens economiques et experimentaux pour separer les diverses sources d'erreurs de mesure. On a cree ou adapte des methodes permettant de maintenir et de controler la precision des mesures courantes. Toutes ces techniques exigent qu'au moins un certain nombre de mesures soient faites deux fois; mais la repetition de toutes les mesures n'est justifiee que lorsqu'il est extremement important de detecter toute erreur grossiere. On peut considerer trois sortes d'erreurs systematiques dans les mesures: 1. l'erreur par rapport a un etalon, 2. l'erreur par rapport aux resultats de mesures precedentes, 3. l'erreur propre a un groupe.. La premiere est la deviation systematique des mesures obtenues par rapport a un ' etalon ' exempt de deviation, soit par definition, soit parce que l'on a supprime toutes les causes connues de deviation. La deuxieme concerne des differences systematiques observees sur un certain laps de temps. La troisieme concerne le rapport entre differentes entites ou individualites physiques a un moment donne. L'auteur expose les moyens les plus recents de la methodologie statistique applicables a l'evaluation de chacune de ces trois sortes d'erreurs systematiques. H donne des exemples d'utilisation des methodes statistiques appliquees aux donnees concernant le reacteur de Hanford. (author) [Spanish] La eficacia de la administracion de los materiales nucleares y, por tanto, la organizacion y el funcionamiento de los

  5. PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

    DEFF Research Database (Denmark)

    Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

    2016-01-01

    Overexpression of urokinase-type plasminogen activator receptors (uPAR) represents an important biomarker for aggressiveness in most common malignant diseases, including prostate cancer (PC). Accordingly, uPAR expression either assessed directly in malignant PC tissue or assessed directly in plasma...... and prognostic imaging method. In this review, we will focus on the recent development of uPAR PET and the relevance within prostate cancer imaging. Novel antibody and small-molecule radiotracers-targeting uPAR, including a series of uPAR-targeting PET ligands, based on the high affinity peptide ligand AE105......, have been synthesized and tested in vitro and in vivo in preclinical murine xenograft models and, recently, in a first-ever clinical uPAR PET study in cancer patients, including patients with PC. In this phase I study, a high and specific uptake of the tracer 64Cu-DOTA-AE105 was found in both primary...

  6. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  7. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Directory of Open Access Journals (Sweden)

    Mutoh T

    2012-08-01

    Full Text Available Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females after 25-gauge pars plana vitrectomy (PPV. One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedure were not administered in three of the four cases. Endophthalmitis occurred 2–4 days after the first procedure in all cases, for which ceftazidime 2.0 mg/0.1 mL and vancomycin 1.0 mg/0.1 mL were injected into the vitreous cavity. This was followed by emergent 20-gauge PPV and intraocular lens removal using an infusion fluid containing ceftazidime and vancomycin. After the second PPV procedure, progress was good in three cases while retinal detachment occurred in the remaining case one month after surgery; this case required a third PPV procedure. Final best-corrected visual acuity ranged from 20/100 to 20/25 for the four cases. Bacterial cultures were negative after the second PPV procedure in all cases. In conclusion, postoperative endophthalmitis occurred in four of 502 cases (0.80% that underwent 25-gauge PPV at our hospital. It is important to minimize the incidence of endophthalmitis after 25-gauge PPV.Keywords: 25-gauge pars plana vitrectomy, endophthalmitis, incidence

  8. Stress reactions involving the pars interarticularis in young athletes

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.

  9. Stress reactions involving the pars interarticularis in young athletes

    International Nuclear Information System (INIS)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    1981-01-01

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated

  10. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Botswana, ce sont les jeunes femmes qui sont le plus touchées par les nouvelles infections par le VIH. Le présent projet a pour but de réduire le nombre de nouveaux cas d'infection par le VIH, en particulier chez les femmes de 15 à 29 ans. Bien que l'on recense des cas de VIH/sida dans la plupart des régions du ...

  11. Rôle de la dispersion dans la réponse des populations de truites aux habitats formés par les grands débris ligneux dans les ruisseaux de montagne du Colorado

    Directory of Open Access Journals (Sweden)

    FAUSCH K. D.

    1995-04-01

    Full Text Available Un peu partout dans le monde, les aménagistes des pêches utilisent souvent des rondins pour réaliser des mouilles pour les salmonidés, souvent pour compenser l'absence de grands débris ligneux (LWD due à la déforestation ou à d'autres perturbations des forêts alluviales. Des mesures des LWD réalisées sur 11 ruisseaux de montagne du Colorado drainant de vieilles forêts de résineux (Picea - Abies montrent qu'ils sont à l'origine de la plupart des mouilles. Les morceaux qui contribuent à la formation des mouilles sont, en moyenne, plus grands que ceux qui n'en forment pas. La plupart enjambe le chenal perpendiculairement à l'écoulement et forme des mouilles de chute («plunge pool» et des mouilles de retenue («dammed pool». Les aménagistes des pêches qui utilisent des troncs perpendiculaires à l'écoulement pour réaliser des mouilles considèrent généralement que cette addition d'habitat améliore la survie des salmonidés résidents pendant les périodes critiques comme l'hiver. Une expérience de longue durée, réalisée pour tester cette hypothèse dans six ruisseaux de montagne du Colorado, a montré que les populations de truites résidentes augmentaient rapidement et significativement dans des portions expérimentales de 250m, par rapport à des témoins adjacents. Cependant, des mesures de la dispersion réalisées par des piégeages et des recaptures de truites marquées ont montré que les mouilles formées par des troncs augmentent les populations de truites adultes en permettant aux truites qui étaient en phase de déplacement de rester dans les portions expérimentales plutôt qu'en améliorant la survie hivernale sur place, comme le décrivent d'autres auteurs. La recherche sur les salmonidés d'eau courante non migrateurs et leur gestion a jusqu'à présent été marquée par un modèle impliquant des déplacements limités, ce qui implique que les adultes soient relativement sédentaires. Cependant, l

  12. Magnetic resonance imaging in Parkinson's disease; The evaluation of the width of pars compacta on T2 weighted image

    Energy Technology Data Exchange (ETDEWEB)

    Moriwaka, Fumio; Tashiro, Kunio; Itoh, Kazunori; Miyasaka, Kazuo [Hokkaido Univ., Sapporo (Japan). School of Medicine; Hamada, Takeshi

    1992-01-01

    The width of substantia nigra (SN) in 59 cases of idiopathic Parkinson's disease as well as 21 normal controls was analyzed by T2 weighted image (T2WI) of 1.5 Tesla high-field magnetic resonance image (MRI). All patients and controls underwent MRI with the spin-echo sequences used TR/TE: 3000/30 (short TE), and TR/TE: 3000/80 (long TE), in 5-mm-thick volumes. The width between the red nucleus and the cerebral peduncle showing low signal intensity areas was measured as that of SN and its ratio to the distance from the aqueduct to the midline of the cerebral peduncle was also measured. The calculated values of the width of SN and its ratio were analyzed by Mann-Whitney test. The significant reduction in the width of SN and its ratio in Parkinson's disease were disclosed below: the mean calculated values of the width of SN were 2.95{+-}0.51 mm in controls, 2.68{+-}0.99 mm in Parkinson's disase on long TE images (P<0.01), and the mean ratio of the width of SN were 13.58{+-}4.21% in controls, 10.52{+-}3.07% in Parkinson's disease on long TE images (P=0.0002). The narrowing of SN in Parkinson's disease was more prominent in men, and advanced cases with Yahr stage III and IV. Considering that the pars reticulata, which is normally containing iron, shows low signal intensity on long TE images, the width of pars compacta could be measured more precisely on this sequences. The evaluation of the ratio of SN in midbrain on long TE images seemed to be more sensitive than the calculated values in detecting the narrowing of SN and pars compacta in Parkinson's disease. (author).

  13. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  14. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Homma, Taihei [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shimizu, Miho [Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kuroda, Reiko, E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

    2011-01-07

    Research highlights: {yields} The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. {yields} L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. {yields} Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  15. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    International Nuclear Information System (INIS)

    Homma, Taihei; Shimizu, Miho; Kuroda, Reiko

    2011-01-01

    Research highlights: → The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. → L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. → Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  16. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.

    Science.gov (United States)

    Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik; Perrin, Mary; Opler, Mark G; Kleinhaus, Karine; Harlap, Susan; Goetz, Raymond; Antonius, Daniel

    2011-05-01

    Paternal age related schizophrenia (PARS) has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering analysis approach to generate hypotheses about differences between PARS and other cases of schizophrenia. We studied PARS (operationally defined as not having any family history of schizophrenia among first and second-degree relatives and fathers' age at birth ≥ 35 years) in a series of schizophrenia cases recruited from a research unit. Data were available on demographic variables, symptoms (Positive and Negative Syndrome Scale; PANSS), cognitive tests (Wechsler Adult Intelligence Scale-Revised; WAIS-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS. Two analyses generated clusters with high concentrations of PARS cases. The first analysis (N=136; PARS=34) revealed a cluster containing 83% PARS cases, in which the patients showed a significant discrepancy between verbal and performance intelligence. The mean paternal and maternal ages were 41 and 33, respectively. The second analysis (N=123; PARS=30) revealed a cluster containing 71% PARS cases, of which 93% were females; the mean age of onset of psychosis, at 17.2, was significantly early. These results strengthen the evidence that PARS cases differ from other patients with schizophrenia. Hypothesis-generating findings suggest that features of PARS may include a discrepancy between verbal and performance intelligence, and in females, an early age of onset. These findings provide a rationale for separating these phenotypes from others in future clinical, genetic and pathophysiologic studies of schizophrenia and in considering responses to treatment. Copyright © 2011 Elsevier B.V. All rights reserved.

  17. Electron microscope study of vacancy clusters produced by quenching in magnesium; Etude par microscopie electronique des amas de lacunes crees par trempe dans le magnesium

    Energy Technology Data Exchange (ETDEWEB)

    Levy, V; Espinasse, J; Mairy, C; Hillairet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    Vacancy clustering in quenched magnesium has been studied by transmission electron microscopy. The nature of the vacancy loops observed, seems to depend essentially on the impurity content of the metal; this effect can be attributed to a variation of the stacking fault energy of magnesium due to impurities. (authors) [French] On a etudie par microscopie electronique en transmission les defauts crees par trempe dans le magnesium. Un effet considerable des impuretes du metal sur la nature des boucles obtenues par condensation de lacunes a ete mis en evidence; cet effet semble s'expliquer de facon satisfaisante par un abaissement de l'energie de faute d'empilement du magnesium du aux impuretes. (auteur)

  18. Study of Combined Treatment for Damp-Harvested Maize: Gamma Irradiation and Drying by Controlled Ventilation; Etude d'un Traitement Combine pour le Conditionnement du Mais Recolte Humide: Irradiation Gamma et Sechage par Ventilation Controlee; Izuchenie kombinirovannoj obrabotki kukuruzy molochno-voskovoj spelosti; Estudio de un Tratamiento Combinado para el Acondicionamiento del Maiz Recolectado Humedo: Irradiacion Gamma y Secado por Ventilacion Controlada

    Energy Technology Data Exchange (ETDEWEB)

    Saint-Lebe, L.; Pelegrin, P. [Centre d' Etudes Nucleaires de Cadarache (France); Guilbot, A. [Institut National de la Recherche Agronomique, Massy (France)

    1966-11-15

    . From the qualitative point of view, the mycoflora which regenerates first is specifically sensitive to the dry air flow which will reach it. Industrial applications are envisaged, but before going on to the pilot stage, which is indispensable for establishing costs, the biochemical investigations must be taken further. The public health aspect must also be studied in case the process finds a use in the field of animal or human feeding. (author) [French] L'association des effets d'une irradiation gamma au cobalt-60 et d'un sechage lent par ventilation froide (10 a 25 Degree-Sign C) dans les cellules de stockage a pour but de substituer a la solution classique de sechage rapide.avec de l'air porte a haute temperature un traitement qui respecte davantage l'integrite du grain et se traduit en meme temps par un assainissement sur le plan microbiologique. Ce probleme concerne en France un million de tonnes de maies humide (1964); il doit revetir une importance croissante tant en Europe que dans les pays de la zone tropicale. Les auteurs etudient d'abord l'incidence directe du rayonnement gamma sur le rendement et les caracteristiques techniques de l'amidon. Celui-ci est extrait du mais par une methode de laboratoire qui reproduit de maniere fidele et precise les conditions industrielles. On trouve qu'un dose d'irradiation inferieure a 500 krad est sans influence sur le rendement d'extraction, alors qu'un sechage a la temperature de 74 Degree-Sign C diminue deja ce rendement d'environ 4%, en raison de la coagulation partielle de la trame proteique et de l'eclatement de granules d'amidon. Les faibles modifications de structure de l'amidon irradie sont dans la plupart des cas favprables du point de vue du traitement ulterieur du produit. Elles peuvent conduire a la mise au point d'un test permettant de savoir si l'amidon ou le maies ont ete irradies. Des techniques d'analyses microbiologiques ont ete mises au point dans le but de definir, en fonction du milieu, les conditions

  19. Neutrons detection by scintillation; Detection de neutrons par scintillations

    Energy Technology Data Exchange (ETDEWEB)

    Giraudon, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1955-01-15

    The absence of charge of neutrons and their elevated penetration power make difficult their detection. Techniques vary otherwise with the energy of the particle. The author proposes the realization of a scintillation detector with a big volume of liquid scintillator and containing boron for the detection of slowing-down neutrons in the domain of intermediate energies from 1 to 10{sup 5} eV about. (M.B.) [French] L'absence de charge du neutron et son pouvoir de penetration eleve rendent difficile sa detection. Les techniques par ailleurs varient avec l'energie de cette particule. L'auteur propose la realisation d'un detecteur a scintillations comprenant un grand volume de scintillateur liquide et contenant du bore pour la detection des neutrons en ralentissement dans le domaine des energies intermediaires de 1 a 10{sup 5} eV environ. (M.B.)

  20. Cancro em mogno africano no estado do Pará

    Directory of Open Access Journals (Sweden)

    Célia Regina Tremacoldi

    2013-06-01

    Full Text Available Sintomas de cancro foram observados em plantios de mogno africano, no município de Dom Eliseu, Pará. Os fungos associados aos tecidos sintomáticos foram identificados como Lasiodiplodia theobromae e Fusarium subglutinans. Culturas puras desses fungos foram testadas quanto à patogenicidade em mudas de mogno africano sadias. Apenas L. theobromae produziu cancro, por meio de inoculação por ferimento e alta umidade. A confirmação de L. theobromae como agente causal do cancro ocorreu após o reisolamento do fungo a partir das plantas inoculadas em casa de vegetação, concluindo a primeira verificação do postulado de Koch para esse patossistema.

  1. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  2. Pierre Vilar Frontinhan 1906 - París 2003

    Directory of Open Access Journals (Sweden)

    Pablo Rodríguez

    2003-01-01

    Full Text Available En el pasado mes de agosto falleció en París el historiador y maestro de tantas generaciones Pierre Vilar. Aunque había mantenido una intensa actividad de reflexión sobre los sucesos contemporáneos, ésta se vio afectada en 1991 luego que una grave enfermedad le negó la visión. Fue entonces cuando decidió con la ayuda de Rosa Congost escribir sus reflexiones y recuerdos, especie de memoria de juventud. Pensar Históricamente (Barcelona: Editorial Crítica, 1997, el libro que reúne estos ejercicios, es una obra de sumo interés para conocer la infancia, adolescencia y juventud de este connotado historiador.

  3. Neutrons detection by scintillation; Detection de neutrons par scintillations

    Energy Technology Data Exchange (ETDEWEB)

    Giraudon, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1955-01-15

    The absence of charge of neutrons and their elevated penetration power make difficult their detection. Techniques vary otherwise with the energy of the particle. The author proposes the realization of a scintillation detector with a big volume of liquid scintillator and containing boron for the detection of slowing-down neutrons in the domain of intermediate energies from 1 to 10{sup 5} eV about. (M.B.) [French] L'absence de charge du neutron et son pouvoir de penetration eleve rendent difficile sa detection. Les techniques par ailleurs varient avec l'energie de cette particule. L'auteur propose la realisation d'un detecteur a scintillations comprenant un grand volume de scintillateur liquide et contenant du bore pour la detection des neutrons en ralentissement dans le domaine des energies intermediaires de 1 a 10{sup 5} eV environ. (M.B.)

  4. Determination of tritium by counting; Dosage du tritium par comptage

    Energy Technology Data Exchange (ETDEWEB)

    Schott, R; Froment, G; Pinson, J; Genty, C [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1968-07-01

    Ionisation chamber assay of tritium in any gaseous mixture is a simple, fast and accurate method. We used the method of relative determination by comparison to a standard rather than the method of absolute assay in which case the constants are known with too little accuracy. The efficiency of the chamber was studied in connection to the pressure inside the chamber and its total volume. The calibration is linear in the range we are taking into account (1 to 80 millicuries). The reproducibility of the method is good: 13 runs gave a coefficient of variation of 1.6 per cent. The relative accuracy was found equal to {+-} 1.3 per cent. To end the paper, we describe in detail the apparatus and the ways of proceedings. (authors) [French] Le comptage du tritium par chambre d'ionisation est une methode simple, rapide et precise pour determiner la teneur en tritium d'un melange gazeux quelconque. Nous avons prefere utiliser la methode de determination relative par rapport a un etalon car, dans le cas d'une determination absolue, les constantes sont connues avec une trop grande incertitude. L'efficacite de la chambre a ete etudiee en fonction de la variation de la pression d'argon a l'interieur de la chambre et du volume total, de cette derniere. L'etalonnage s'est revele lineaire dans le domaine de mesures qui nous interessaient (1 a 80 millicuries). La reproductibillte de la methode est tres bonne, le coefficient de variation pour une serie de 13 essais etant de 1,6 pour cent, quant a la precision relative, elle a ete evaluee a {+-} 1,3 pour cent. Pour terminer, nous donnons une description detaillee de l'appareillage utilise et du mode operatoire suivi. (auteurs)

  5. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  6. Coeficiente de repetibilidade e parâmetros genéticos em capim-elefante

    Directory of Open Access Journals (Sweden)

    Marcelo Cavalcante

    2012-04-01

    Full Text Available O objetivo deste trabalho foi determinar os coeficientes de repetibilidade de caracteres morfofisiológicos em genótipos de capim-elefante (Pennisetum spp., a partir de dados obtidos durante seis ciclos de avaliação. Foram estimados: número mínimo de medições e parâmetros genéticos. Utilizou-se o delineamento experimental de blocos ao acaso, em arranjo de parcelas subdivididas, com quatro níveis de N (controle, 30, 60 e 90 kg ha‑1 por corte e 16 genótipos de Pennisetum (11 híbridos interespecíficos e cinco cultivares. Os ciclos consistiram de avaliações em 2010 (21/4, 19/7 e 28/9 e 2011 (6/1, 7/4 e 3/8. Os coeficientes de repetibilidade foram de média‑alta magnitude para todas as variáveis, o que indica que houve regularidade entre as medidas repetidas. Para as variáveis massa de forragem, altura da planta, comprimento e largura da folha, diâmetro do colmo, clorose e índice de área foliar, três ciclos de avaliação são suficientes para obter R² de 90%, pela análise de componentes principais. Para o comprimento do entrenó, o mínimo de sete avaliações é necessário para predizer o valor real dos genótipos. Os parâmetros genéticos das variáveis massa de forragem, comprimento e largura da folha, diâmetro do colmo e clorose foliar são de alta magnitude, o que favorece a seleção de genótipos superiores de Pennisetum.

  7. LONG-TERM INTRAOCULAR PRESSURE AFTER UNCOMPLICATED PARS PLANA VITRECTOMY FOR IDIOPATHIC EPIRETINAL MEMBRANE.

    Science.gov (United States)

    Tognetto, Daniele; Pastore, Marco R; Cirigliano, Gabriella; DʼAloisio, Rossella; Borelli, Massimo; De Giacinto, Chiara

    2017-11-16

    To investigate long-term intraocular pressure trends after uncomplicated pars plana vitrectomy for idiopathic epiretinal membrane. Three hundred and sixty-eight eyes of 368 consecutive patients were enrolled. Changes in intraocular pressure 1, 3, 6, and 12 months after surgery and during the final follow-up visit were evaluated in vitrectomized eyes and nonvitrectomized fellow eyes. The median follow-up period was 36 months (range 12-92 months). Longitudinal data analysis evidenced a 2.5-mmHg (2.2 mmHg; 2.7 mmHg, 95% confidence interval) statistically significant difference in intraocular pressure 30 days after surgery between treated and fellow untreated eyes, gradually recovering to a not significant 0.2-mmHg (-0.1 mmHg; 0.4 mmHg, 95% confidence interval) difference within 26 months. The incidence of late-onset ocular hypertension was 5.7% (21 over 347, 2%; 12%, 95% confidence interval) without difference between the treated eyes and the group control. No significant difference in the incidence of late-onset ocular hypertension and sex, lens status, or gauge of vitrectomy instruments was detected. Only patient's age was significantly higher (mean difference 4.2 years; 0.1-8.0 years, Monte Carlo, 95% confidence interval) in those who developed late-onset ocular hypertension in the vitrectomized eye. Uncomplicated pars plana vitrectomy for idiopathic epiretinal membrane seems not to increase the risk of late-onset ocular hypertension or open-angle glaucoma development.

  8. Application of Radiation for the Control of Salmonellae in Various Foods; Destruction des Salmonellae par les Rayonnements dans Divers Produits Alimentaires; Primenenie izluchenij dlya unichtozheniya salmonell v razlichnykh pishchevykh produktakh; Empleo de las Radiaciones Ionizantes en la Lucha Contra las Salmonellae de Diferentes Aumentos

    Energy Technology Data Exchange (ETDEWEB)

    Ley, F. J. [Wantage Research Laboratory (A.E.R.E.), Wantage, Berks. (United Kingdom)

    1966-11-15

    serologiques presentes. Etant donne que ces conditions ne peuvent jamais etre reproduites exactement en laboratoire, le choix de la dose doit etre confirme par des recherches suffisamment etendues sur le meme produit contamine par voie naturelle. Il est apparu que, pour traiter differents produits alimentaires, il faut utiliser des doses comprises entre 0,5 et.1,0 Mrad qui permettent de reduire d'un facteur allant de 10{sup 5} a 10{sup 7} l'importance numerique des populations initiales. Les procedes qui semblent devoir donner de meilleurs resultats sont ceux que l'on envisage d'utiliser pour les produits a base d'oeufs congeles et deshydrates, les viandes congelees et les produits destines a l'alimentation animale. (author) [Spanish] Los estudios microbiologicos sobre el empleo de las radiaciones ionizantes para eliminar las Salmonellae de varios alimentos muestran que en la radiosensibilidad de esos microorganismos puede influir toda una serie de factores. Entre estos cabe citar la naturaleza del propio alimento y su temperatura durante la irradiacion, por ejemplo, si esta congelado o sin congelar. Tambien se han puesto claramente de manifiesto las diferencias de resistencia de distintos serotipos de Salmonellae irradiados en identicas condiciones. Por consiguiente, las curvas de dosis/supervivencia, que se preparen con el fin de seleccionar la dosis para una aplicacion particular, deben trazarse con arreglo a las condiciones practicas que se prevean y basarse en el serotipo mas resistente de los presentes. Como estas condiciones nunca pueden reproducirse exactamente en el laboratorio, la eleccion de la dosis debe confirmarse realizando amplios trabajos con alimentos naturalmente contaminados. Se llega a la conclusion de que las dosis necessarias para tratar varios alimentos son del orden de 0,5 a 1,0 Mrad, con lo que se logra reducir entre 10{sup 5} y 10{sup 7} veces la poblacion inicial. Los procedimientos mas interesantes son los aplicados a los huevos congelados y

  9. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    DEFF Research Database (Denmark)

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    modalities such as optical imaging, magnetic resonance imaging, single photon emission computer tomography (SPECT) and positron emission topography (PET). In this review, we will discuss recent advances in the development of uPAR-targeted imaging ligands according to imaging modality. In addition, we...... will discuss the potential future clinical application for uPAR imaging as a new imaging biomarker....

  10. Pars plana vitrectomy for disturbing primary vitreous floaters: clinical outcome and patient satisfaction

    NARCIS (Netherlands)

    Nie, K.F. de; Crama, N.; Tilanus, M.A.D.; Klevering, B.J.; Boon, C.J.F.

    2013-01-01

    BACKGROUND: Primary vitreous floaters can be highly bothersome in some patients. In the case of persistently bothersome floaters, pars plana vitrectomy may be the most effective treatment. The aim of this study is to evaluate the incidence of complications, and patient satisfaction, after pars plana

  11. Spectral variations of UV-A and PAR solar radiation in estuarine waters of Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Talaulikar, M.; Suresh, T.; Silveira, N.; Desa, E.; Matondkar, S; Lotlikar, A

    radiation (400 to 700 nm), PAR and ultraviolet radiation in the range 350-400 nm (UV-A) are presented here. The mean PAR values at the surface were 327 W/m sup(2) and reduced to 84 W/m sup(2) at first optical depth, Z sub(90) (m) in water. The first optical...

  12. Narrative Identities and the Plebiscite in Pará: An Analysis of the Front Pages for O Liberal and Diário do Pará

    Directory of Open Access Journals (Sweden)

    Alda Cristina Silva da Costa

    2017-05-01

    Full Text Available On December 11, 2011, a plebiscite was held in Pará proposing to create two separatist states, Carajás and Tapajós, out of the state of Pará. The public voted against both projects. This article analyzes the narrative identities found on the front pages of O Liberal and Diário do Pará newspapers about the plebiscite in Pará. Depth Hermeneutics (DH, as proposed by Thompson (2011, was used as the methodological reference. DH emphasizes the object of analysis as a meaningful symbolic construction requiring interpretation. Narrative analysis, as proposed by Motta (2007, was the main research technique used to highlight the movement of construction of journalistic (discursive characters. The narrative identities built by the two newspapers showed that both were against the creation of the new states, but for very different reasons. The flag of Pará was the main object used to induce the idea of unity. Em 11 de dezembro de 2011, o plebiscito no Pará propôs a criação dos estados de Carajás e de Tapajós a partir da divisão do estado do Pará. O resultado da consulta pública foi negativo aos dois projetos. O artigo analisa as identidades narrativas constituídas pelas primeiras páginas dos jornais O Liberal e Diário do Pará sobre o plebiscito no Pará. Utilizou-se como referencial metodológico a Hermenêutica em Profundidade (HP, proposta por Thompson (2011. A HP evidencia o fato de que o objeto de análise é uma construção simbólica significativa, que exige uma interpretação. Como principal técnica de pesquisa, a análise narrativa, proposta por Motta (2007, com ênfase no movimento de construção de personagens jornalísticas (discursivas. As identidades narrativas construídas pelos dois jornais indicaram que ambos eram contrários à criação dos novos estados, porém por motivos divergentes. A bandeira do Pará foi o principal elemento utilizado para evocar a ideia de unidade. En 11 de diciembre de 2011, el plebiscito en

  13. New peptide receptor radionuclide therapy of invasive cancer cells: in vivo studies using 177Lu-DOTA-AE105 targeting uPAR in human colorectal cancer xenografts

    International Nuclear Information System (INIS)

    Persson, Morten; Rasmussen, Palle; Madsen, Jacob; Ploug, Michael; Kjaer, Andreas

    2012-01-01

    The proposition of uPAR as a potential target in cancer therapy is advanced by its predominant expression at the invasive front of colorectal cancer (CRC) and its value as prognostic biomarker for poor survival in this disease. In this study, we provide the first in vivo proof-of-concept for a theranostic approach as treatment modality in a human xenograft colorectal cancer model. Methods: A DOTA-conjugated 9-mer high affinity uPAR binding peptide (DOTA-AE105) was radiolabeled with 64 Cu and 177 Lu, for PET imaging and targeted radionuclide therapy study, respectively. Human uPAR-positive CRC HT-29 cells were inoculated in Nude mice and treated with 177 Lu-DOTA-AE105 once a visible tumor had formed. To evaluate the true effect of the targeted radiotherapy, two controls groups were included in this study, one receiving a 177 Lu-labeled non-binding control peptide and one receiving vehicle. All animals were treated day 0 and 7. A parallel 18 F-FLT PET/CT study was performed on day 0, 1, 3 and 6. Dosimetry calculations were based on a biodistribution study, where organs and tissue of interest were collected 0.5, 1.0, 2.0, 4.0 and 24 h post injection of 177 Lu-DOTA-AE105. Toxicity was assessed by recording mouse weight and by H and E staining of kidneys in each treatment group. Results: uPAR-positive HT-29 xenograft was clearly visualized by PET/CT imaging using 64 Cu-DOTA-AE105. Subsequently, these xenograft transplants were locally irradiated using 177 Lu-DOTA-AE105, where a significant effect on tumor size and the number of uPAR-positive cells in the tumor was found (p 18 F-FLT PET/CT imaging study revealed a significant correlation between 18 F-FLT tumor uptake and efficacy of the radionuclide therapy. A histological examination of the kidneys from one animal in each treatment group did not reveal any gross abnormalities and the general performance of all treated animals also showed no indications of radioactivity-induced toxicity. Conclusion: These findings

  14. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

    DEFF Research Database (Denmark)

    Behrendt, Niels

    2004-01-01

    The breakdown of the barriers formed by extracellular matrix proteins is a pre-requisite for all processes of tissue remodeling. Matrix degradation reactions take part in specific physiological events in the healthy organism but also represent a crucial step in cancer invasion. These degradation...... on the surface of various cell types that serves to bind the urokinase plasminogen activator and localize the activation reactions in the proteolytic cascade system of plasminogen activation. uPARAP is an integral membrane protein with a pronounced role in the internalization of collagen for intracellular...... degradation. Both receptors have additional functions that are currently being unraveled. The present discussion of uPAR and uPARAP is centered on their protein structure and molecular and cellular function....

  15. Effect of simvastatin and ezetimibe on suPAR levels and outcomes

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Forman, Julie L

    2018-01-01

    -lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using...... and Ezetimibe treatment impeded the progression of the time-related increase in plasma suPAR levels. Year-1 suPAR was associated with all-cause mortality, MCE, and AVE irrespective of baseline levels (SEAS study: NCT00092677)....... cardiovascular events (MCE) composed of ischemic cardiovascular events (ICE) and aortic valve related events (AVE). RESULTS: After 4.3 years of follow-up, suPAR levels had increased by 9.2% (95% confidence interval [CI]: 7.0%-11.5%) in the placebo group, but only by 4.1% (1.9%-6.2%) in the group with lipid...

  16. Brulure par Plaque de Bistouri Electrique: a Propos de Quatre Cas

    Science.gov (United States)

    Khales, A.; Achbouk, A.; Belmir, R.; Cherkab, L.; Ennouhi, M.A.; Ababou, K.; Ihrai, H.

    2010-01-01

    Summary La brûlure par plaque de bistouri électrique est un accident rare mais grave par la profondeur de la lésion et par sa localisation, surtout quand qu’elle survient dans un contexte chirurgical dont le vécu reste difficile de la part du malade et du chirurgien. Cette brûlure bien que imprévisible reste grave par la profondeur et la localisation de la brûlure et par sa survenue dans un contexte opératoire, chez des patients malades. La prise en charge de la brûlure doit se faire en milieu spécialisé. La prévention reste le seul moyen d’éviter ce type d’accident. PMID:21991216

  17. par genes in Mycobacterium bovis and Mycobacterium smegmatis are arranged in an operon transcribed from "SigGC" promoters

    Directory of Open Access Journals (Sweden)

    Casart Yveth

    2008-03-01

    Full Text Available Abstract Background The ParA/Soj and ParB/Spo0J proteins, and the cis-acting parS site, participate actively in chromosome segregation and cell cycle progression. Genes homologous to parA and parB, and two putative parS copies, have been identified in the Mycobacterium bovis BCG and Mycobacterium smegmatis chromosomes. As in Mycobacterium tuberculosis, the parA and parB genes in these two non-pathogenic mycobacteria are located near the chromosomal origin of replication. The present work focused on the determination of the transcriptional organisation of the ~6 Kb orf60K-parB region of M. bovis BCG and M. smegmatis by primer extension, transcriptional fusions to the green fluorescence protein (GFP and quantitative RT-PCR. Results The parAB genes were arranged in an operon. However, we also found promoters upstream of each one of these genes. Seven putative promoter sequences were identified in the orf60K-parB region of M. bovis BCG, whilst four were identified in the homologous region of M. smegmatis, one upstream of each open reading frame (ORF. Real-time PCR assays showed that in M. smegmatis, mRNA-parA and mRNA-parB levels decreased between the exponential and stationary phases. In M. bovis BCG, mRNA-parA levels also decreased between the exponential and stationary phases. However, parB expression was higher than parA expression and remained almost unchanged along the growth curve. Conclusion The majority of the proposed promoter regions had features characteristic of Mycobacterium promoters previously denoted as Group D. The -10 hexamer of a strong E. coli σ70-like promoter, located upstream of gidB of M. bovis BCG, overlapped with a putative parS sequence, suggesting that the transcription from this promoter might be regulated by the binding of ParB to parS.

  18. Krsko NPP Quality Assurance Plan Application to Nuclear Safety Upgrade Projects (PCFV System and PAR System)

    International Nuclear Information System (INIS)

    Biscan, Romeo; Fifnja, Igor

    2014-01-01

    Nuklearna Elektrarna Krsko (NEK) has undertaken Nuclear Safety Upgrade Projects as a safety improvement driven by the lessons learned from the Fukushima-Daiichi Accident. Among other projects, new modification 1008-VA-L Passive Containment Filtered Vent (PCFV) System has been installed which acts as the last barrier minimizing the release of radioactive material into the environment in case of failure of all safety systems, and to insure containment integrity during beyond design basis accidents (BDBA). In addition, modification 1002-GH-L Severe Accident Hydrogen Control System (PAR) has been implemented to prevent and mitigate the consequences of explosive gas generation (hydrogen and carbon monoxide) in case of reactor core melting. To ensure containment integrity for all design basis accidents (DBA) and BDBA conditions, NEK has eliminated existing safety-related electrical recombiners, replaced them with two safety-related passive autocatalytic recombiners (PARs) and added 20 new PARs designed for the BDBA conditions. Krsko NPP Quality Assurance Plan has been applied to Nuclear Safety Upgrade Projects (PCFV System and PAR System) through the following activities: · Internal audit of modification process was performed. · Supplier audits were performed to evaluate QA program efficiency of the main design organization and engineering organizations. · Evaluation and approval of Suppliers were performed. · QA engineer was involved in the review and approval of 1008-VA-L and 1002-GH-L modification documentation (Conceptual Design Package, Design Modification Package, Installation Package, Field Design Change Request, Problem/Deficiency Report, and Final Documentation Package). · Purchasing documentation for modifications 1008-VA-L and 1002-GH-L (technical specifications, purchase orders) has been verified and approved by QA. · QA and QC engineers were involved in oversight of production and testing of the new 1008-VA-L and 1002-GH-L plant components.

  19. Parálisis facial periférica después de amigdalectomía extracapsular

    Directory of Open Access Journals (Sweden)

    Erwin Alejandro Racines-Alava

    2018-05-01

    ía, que se relacionan con la apertura forzada de la vía aérea en caso de intubación difícil o por la infiltración anestésica y su difusión. Por la forma de presentación y su rápida desaparición nos inclinamos a pensar en que nuestros casos son del segundo tipo. Conclusiones: La infiltración periamigdalina de anestésico local durante la amigdalectomía puede aportar un beneficio al reducir el sangrado y el tiempo quirúrgico, además de ayudar al control del dolor postoperatoio. Al ser un procedimiento común en Otorrinolaringología debemos conocer la anatomía quirúrgica y los sitios de infiltración de anestésico local y su adecuada cantidad para cada paciente. La parálisis facial periférica es una rara complicación, puede ser transitoria y recuperarse espontáneamente sin necesitar ningún tratamiento.

  20. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  1. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2010-01-01

    -suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  2. Elastic and inelastic scattering of 2 to 10 MeV protons by lithium isotopes; Diffusion elastique et inelastique des protons de 2 a 10 MeV par les isotopes du lithium

    Energy Technology Data Exchange (ETDEWEB)

    Laurat, M [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1969-07-01

    A description is given of the experimental set-up which has been devised for carrying out spectrometric and absolute cross-section measurements on the reactions induced by protons accelerated in a 12 MeV Van de Graaff Tandem. The particles are detected by silicon junctions; the weight of the targets (about ten {mu}g/cm{sup 2}) is determined by the quartz method. The experimental equipment has been controlled by a study of proton scattering by lithium-6, and has made it possible to evaluate the elastic and inelastic scattering (1. level excitation) by lithium 7 of 2 to 9 MeV protons. The most probable spin and parity values for the six levels of {sup 8}Be between 19 and 25 MeV excitation energy have been determined from a knowledge of the observed structure. (author) [French] Nous decrivons le dispositif experimental mis au point pour effectuer les mesures de spectrometrie et de section efficace absolue pour les reactions induites par des protons acceleres par un Van de Graaff Tandem 12 MeV. Les particules sont detectees par des jonctions au silicium, le poids des cibles (de l'ordre d'une dizaine de {mu}g/cm{sup 2}), mesure par la methode du quartz. L'ensemble de l'appareillage a ete controle par l'etude de la diffusion des protons par le lithium 6, et nous a permis de preciser les diffusions elastiques et inelastiques (excitation du 1er niveau) des protons de 2 a 9 MeV par le lithium 7. La structure observee a permis de determiner les spin et parite les plus probables de six niveaux du {sup 8}Be entre 19 et 25 MeV d'energie d'excitation. (auteur)

  3. Elastic and inelastic scattering of 2 to 10 MeV protons by lithium isotopes; Diffusion elastique et inelastique des protons de 2 a 10 MeV par les isotopes du lithium

    Energy Technology Data Exchange (ETDEWEB)

    Laurat, M. [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1969-07-01

    A description is given of the experimental set-up which has been devised for carrying out spectrometric and absolute cross-section measurements on the reactions induced by protons accelerated in a 12 MeV Van de Graaff Tandem. The particles are detected by silicon junctions; the weight of the targets (about ten {mu}g/cm{sup 2}) is determined by the quartz method. The experimental equipment has been controlled by a study of proton scattering by lithium-6, and has made it possible to evaluate the elastic and inelastic scattering (1. level excitation) by lithium 7 of 2 to 9 MeV protons. The most probable spin and parity values for the six levels of {sup 8}Be between 19 and 25 MeV excitation energy have been determined from a knowledge of the observed structure. (author) [French] Nous decrivons le dispositif experimental mis au point pour effectuer les mesures de spectrometrie et de section efficace absolue pour les reactions induites par des protons acceleres par un Van de Graaff Tandem 12 MeV. Les particules sont detectees par des jonctions au silicium, le poids des cibles (de l'ordre d'une dizaine de {mu}g/cm{sup 2}), mesure par la methode du quartz. L'ensemble de l'appareillage a ete controle par l'etude de la diffusion des protons par le lithium 6, et nous a permis de preciser les diffusions elastiques et inelastiques (excitation du 1er niveau) des protons de 2 a 9 MeV par le lithium 7. La structure observee a permis de determiner les spin et parite les plus probables de six niveaux du {sup 8}Be entre 19 et 25 MeV d'energie d'excitation. (auteur)

  4. Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis

    Science.gov (United States)

    Stanton, M. Mark; Nelson, Lisa K.; Benediktsson, Hallgrimur; Hollenberg, Morley D.; Buret, Andre G.; Ceri, Howard

    2013-01-01

    Background. Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. Methods. Using a hapten (ethanol-dinitrobenzene sulfonic acid- (DNBS-)) induced prostatitis model with both wild-type and PAR1-null mice, we examined (1) the location of PAR1 in the mouse prostate and (2) the impact of a PAR1-activating peptide (TFLLR-NH2: PAR1-TF) on ethanol-DNBS-induced inflammation. Results. Ethanol-DNBS-induced inflammation was maximal at 2 days. In the tissue, PAR1 was expressed predominantly along the apical acini of prostatic epithelium. Although PAR1-TF on its own did not cause inflammation, its coadministration with ethanol-DNBS reduced all indices of acute prostatitis. Further, PAR1-TF administration doubled the prostatic production of interleukin-10 (IL-10) compared with ethanol-DNBS treatment alone. This enhanced IL-10 was not observed in PAR1-null mice and was not caused by the reverse-sequence receptor-inactive peptide, RLLFT-NH2. Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice. Conclusions. PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis. However, PAR1-TF also diminishes ethanol-DNBS-induced inflammation via a non-PAR1 mechanism by activating an as-yet unknown receptor. PMID:24459330

  5. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  6. Comparaison du Pangola (Digitaria decumbens) et du Stargrass (Cynodon nlemfluensis) exploités par des ovins

    OpenAIRE

    Boval, Maryline

    1989-01-01

    A la Martinique l'utilisation comparée de Digitaria decumbens (Dd) et de Cynodon nlemfuensis (Cn) par des brebis allaitantes a été étudiée pendant une période d'observation de 6 mois. Le cheptel est à un taux élevé de 1 600 kg de poids vif par hectare et par an, obtenu par une fertilisation de 450 kg/ha/an en azote.

  7. Determinação do ponto de carga zero da bauxita da região nordeste do Pará Determination of the zero point of charge of the northeast of Pará bauxite

    Directory of Open Access Journals (Sweden)

    R. L. S. Pinto

    2012-12-01

    Full Text Available No nordeste do Pará o transporte da polpa de bauxita é através de mineroduto, sendo a viscosidade um parâmetro de controle fundamental para o bombeamento do minério. Este estudo ilustra a influência do pH na reologia da polpa por meio da determinação do ponto de carga zero (pHpcz da bauxita. Foram efetuadas análise granulométrica, microscopia eletrônica de varredura, ensaios potenciométricos testando o cloreto de amônia como eletrólito indiferente e ensaios reológicos em diferentes valores de pH. Os resultados revelaram que o cloreto de amônia pode ser utilizado como eletrólito indiferente para esse tipo de análise e que ocorre a redução da viscosidade em valores de pH distantes do ponto de carga zero.In the northeast of Pará, Brazil, the transport of bauxite pulp is through pipeline, being the viscosity a parameter which can interfere in the pumping. This study illustrates the influence of pH on pulp rheology through of determination of the zero point of charge. Were done particle size analysis, SEM, EDS, potentiometric tests testing ammonia chloride as indifferent electrolyte and rheological tests at different pH values. The results revealed that ammonia chloride can be used as indifferent electrolyte and showed a decrease in viscosity when there is far of the zero point of charge.

  8. Improved Satellite-based Photosysnthetically Active Radiation (PAR) for Air Quality Studies

    Science.gov (United States)

    Pour Biazar, A.; McNider, R. T.; Cohan, D. S.; White, A.; Zhang, R.; Dornblaser, B.; Doty, K.; Wu, Y.; Estes, M. J.

    2015-12-01

    One of the challenges in understanding the air quality over forested regions has been the uncertainties in estimating the biogenic hydrocarbon emissions. Biogenic volatile organic compounds, BVOCs, play a critical role in atmospheric chemistry, particularly in ozone and particulate matter (PM) formation. In southeastern United States, BVOCs (mostly as isoprene) are the dominant summertime source of reactive hydrocarbon. Despite significant efforts in improving BVOC estimates, the errors in emission inventories remain a concern. Since BVOC emissions are particularly sensitive to the available photosynthetically active radiation (PAR), model errors in PAR result in large errors in emission estimates. Thus, utilization of satellite observations to estimate PAR can help in reducing emission uncertainties. Satellite-based PAR estimates rely on the technique used to derive insolation from satellite visible brightness measurements. In this study we evaluate several insolation products against surface pyranometer observations and offer a bias correction to generate a more accurate PAR product. The improved PAR product is then used in biogenic emission estimates. The improved biogenic emission estimates are compared to the emission inventories over Texas and used in air quality simulation over the period of August-September 2013 (NASA's Discover-AQ field campaign). A series of sensitivity simulations will be performed and evaluated against Discover-AQ observations to test the impact of satellite-derived PAR on air quality simulations.

  9. Pars plana Ahmed valve and vitrectomy in patients with glaucoma associated with posterior segment disease.

    Science.gov (United States)

    Wallsh, Josh O; Gallemore, Ron P; Taban, Mehran; Hu, Charles; Sharareh, Behnam

    2013-01-01

    To assess the safety and efficacy of a modified technique for pars plana placement of the Ahmed valve in combination with pars plana vitrectomy in the treatment of glaucoma associated with posterior segment disease. Thirty-nine eyes with glaucoma associated with posterior segment disease underwent pars plana vitrectomy combined with Ahmed valve placement. All valves were placed in the pars plana using a modified technique, without the pars plana clip, and using a scleral patch graft. The 24 eyes diagnosed with neovascular glaucoma had an improvement in intraocular pressure from 37.6 mmHg to 13.8 mmHg and best-corrected visual acuity from 2.13 logarithm of minimum angle of resolution to 1.40 logarithm of minimum angle of resolution. Fifteen eyes diagnosed with steroid-induced glaucoma had an improvement in intraocular pressure from 27.9 mmHg to 14.1 mmHg and best-corrected visual acuity from 1.38 logarithm of minimum angle of resolution to 1.13 logarithm of minimum angle of resolution. Complications included four cases of cystic bleb formation and one case of choroidal detachment and explantation for hypotony. Ahmed valve placement through the pars plana during vitrectomy is an effective option for managing complex cases of glaucoma without the use of the pars plana clip.

  10. The pars intermedia: an anatomic basis for a coordinated vascular response to female genital arousal.

    Science.gov (United States)

    Shih, Cheryl; Cold, Christopher J; Yang, Claire C

    2013-06-01

    The pars intermedia is an area of the vulva that has been inconsistently described in the literature. We conducted anatomic studies to better describe the tissues and vascular structures of the pars intermedia and proposed a functional rationale of the pars intermedia in the female sexual response. Nine cadaveric vulvectomy specimens were used. Each was serially sectioned and stained with hematoxylin and eosin and Masson's trichrome. Histologic ultrastructural description of the pars intermedia. The pars intermedia contains veins traveling longitudinally in the angle of the clitoris, supported by collagen-rich stromal tissues. These veins drain the different vascular compartments of the vulva, including the clitoris, the bulbs, and labia minora; also, the interconnecting veins link the different vascular compartments. The pars intermedia is not composed of erectile tissue, distinguishing it from the erectile tissues of the corpora cavernosa of the clitoris as well as the corpus spongiosum of the clitoral (vestibular) bulbs. The venous communications of the pars intermedia, linking the erectile tissues with the other vascular compartments of the vulva, appear to provide the anatomic basis for a coordinated vascular response during female sexual arousal. © 2012 International Society for Sexual Medicine.

  11. Dosing of traces of oxygenated water by polarography; Dosage de traces d'eau oxygenee par polarographie

    Energy Technology Data Exchange (ETDEWEB)

    Faure, A. M.; Malterre, J.

    1960-07-01

    As dosing oxygenated water by using polarography has been envisaged within the framework of water purity controls for the Melusine pile, the objective of the authors is here to see whether the polarographic method could be satisfying for routine analyses, and would result in a higher dosing sensitivity. They describe the polarography principle, indicate devices which are used, specify and comment conditions under which polarography is performed [French] Le dosage de l'eau oxygenee par polarographie a ete envisage dans le cadre des controles de purete de l'eau de la pile Melusine. La methode calorimetrique dans les conditions de fonctionnement de Melusine a puissance maxima, avait mis en evidence des teneurs en H{sub 2}O{sub 2} produites par radiolyse de l'eau, inferieures a 20 ppm. Le but de cette etude, a ete de voir si la methode polarographique pouvait donner satisfaction en analyse de routine a ces teneurs la et permettre une plus grande sensibilite de dosage, la colorimetrie se limitant pratiquement a 1 ppm avec une precision de 20 pour cent environ. (auteurs)

  12. Instrument for continuous supervision of the radioactivity of CO{sub 2} coolant in piles - DCCA -CO{sub 2} (1960); Dispositif de controle continu de la radioactivite du CO{sub 2} de refroidissement des piles - DCCA - CO{sub 2} (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Fitoussi, L [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    This paper describes an apparatus for continuous measurement of CO{sub 2} activity, which can be used on piles cooled by circulation of gas. The first part is devoted mainly to describing the apparatus used and the character of the radioactivity and thermodynamic measurements carried out, and giving the general characteristics of the gas circuit required if the instrument is to be suitably gas-tight. In the second part theoretical calculations are given, particularly on the determination of the ionisation current in an ionisation chamber with circulating gas. Several parameters enter into this determination, such as the mean path of {beta} particles in the ionisation chamber, the linear number of ion pairs formed in the gas by these {beta} particles as a function of their energy, the temperature and pressure of the gas in the ionisation chamber. This part also evaluates the sensitivity areas of the apparatus for measuring the concentrations of radioactive gases such as argon-41 and fission gases from uranium-235 in the CO{sub 2} coolant. In the last part are described the results of measurements performed with such an apparatus on the pile EL2, the special investigations carried out on the CO{sub 2} coolant of this pile, and the information gained during normal operation and during accidents. The DCCA - CO{sub 2} which has just been put in operation at G2 is briefly presented. In the conclusion the possibilities offered by this apparatus are underlined. (author) [French] Ce rapport a pour but de presenter le Dispositif de Controle continu de l'Activite du CO{sub 2} pouvant etre utilise aupres des piles refroidies par une circulation de gaz. La premiere partie du rapport consiste essentiellement a decrire l'ensemble de l'appareillage mis en oeuvre, a preciser la nature des mesures de radioactivite et de thermodynamique effectuees et a citer les caracteristiques generales du circuit de gaz pour avoir un dispositif presentant une etancheite efficace. Dans la seconde

  13. Instrument for continuous supervision of the radioactivity of CO{sub 2} coolant in piles - DCCA -CO{sub 2} (1960); Dispositif de controle continu de la radioactivite du CO{sub 2} de refroidissement des piles - DCCA - CO{sub 2} (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Fitoussi, L. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    This paper describes an apparatus for continuous measurement of CO{sub 2} activity, which can be used on piles cooled by circulation of gas. The first part is devoted mainly to describing the apparatus used and the character of the radioactivity and thermodynamic measurements carried out, and giving the general characteristics of the gas circuit required if the instrument is to be suitably gas-tight. In the second part theoretical calculations are given, particularly on the determination of the ionisation current in an ionisation chamber with circulating gas. Several parameters enter into this determination, such as the mean path of {beta} particles in the ionisation chamber, the linear number of ion pairs formed in the gas by these {beta} particles as a function of their energy, the temperature and pressure of the gas in the ionisation chamber. This part also evaluates the sensitivity areas of the apparatus for measuring the concentrations of radioactive gases such as argon-41 and fission gases from uranium-235 in the CO{sub 2} coolant. In the last part are described the results of measurements performed with such an apparatus on the pile EL2, the special investigations carried out on the CO{sub 2} coolant of this pile, and the information gained during normal operation and during accidents. The DCCA - CO{sub 2} which has just been put in operation at G2 is briefly presented. In the conclusion the possibilities offered by this apparatus are underlined. (author) [French] Ce rapport a pour but de presenter le Dispositif de Controle continu de l'Activite du CO{sub 2} pouvant etre utilise aupres des piles refroidies par une circulation de gaz. La premiere partie du rapport consiste essentiellement a decrire l'ensemble de l'appareillage mis en oeuvre, a preciser la nature des mesures de radioactivite et de thermodynamique effectuees et a citer les caracteristiques generales du circuit de gaz pour avoir un dispositif presentant une etancheite efficace

  14. Hunger amidst plenty along the coast of Pará

    Directory of Open Access Journals (Sweden)

    Ivete Nascimento

    2006-08-01

    Full Text Available In this work one analyzes some referring questions to the new significações of the temporality constructed socially enters the artisan fishing of the coast, in the city of Maracanã, using as boundary-maker the concepts the concepts of abundance and famitura the one that they send themselves to the speech in way of life of the past and the gift. It will see as the typical way of life of the rescued past of the memory of old and the meaning of the abundance in the time of the fishing-farmer, the counterpoint with the concept of famitura of the fishing-exclusive of the gift, where the loss surpasses the scope of the strict survival reaching the proper way of life with the weakness of solidarity. This analysis will be given mecanicamente in the conceptual field of the time measured for the tasks and of the time chronometered for the clock. The intensive field work ocurred on Fortaleza of the Mocooca community incorporating data gotten a long the author's experience in the fish artisan thematic of the Pará coast.

  15. Le Web pour enseigner par projets et favoriser la collaboration

    Directory of Open Access Journals (Sweden)

    Sylvie Ratté

    2004-01-01

    Full Text Available L’utilisation du Web présentée dans cet article vient appuyer une démarche pédagogique fondée sur le partage des savoirs. Dans le contexte d’une simulation industrielle, les étudiants d’un cours de programmation avancée doivent apprendre à partager leur expertise, à communiquer clairement leurs questions, à décrire des problèmes et à faire face à des retournements inattendus. Le Web devient un espace de collaboration pour diffuser les requêtes d’un client fictif, les directives, les travaux préliminaires et les ententes. Les résultats obtenus tendent à suggérer que cette approche globale force l’étudiant à mieux planifier, l’invite à mieux formuler et décrire les problèmes, augmente le niveau de collaboration et facilite la production d’analogies. Un système facilitant la logistique entourant la revue par les pairs (récupération des travaux, construction d’une grille d’évaluation et diffusion des résultats est également présenté.

  16. Design of 118 MHz twelfth harmonic cavity of APS PAR

    International Nuclear Information System (INIS)

    Kang, Y.W.; Kustom, R.L.; Bridges, J.F.

    1992-01-01

    Two radio frequency (RF) cavities are needed in the Positron Accumulator Ring (PAR) of the Advanced Photon Source. One is for the first harmonic frequency at 9.8 MHz, and the other is for the twelfth harmonic frequency at 118 MHz. This note reports on the design of the 118 MHz RF cavity. Computer models are used to find the mode frequencies, impedances, Q-factors, and field distributions in the cavity. The computer codes MAFIA, URMEL, and URMEL-T are useful tools which model and simulate the resonance characteristics of a cavity. These codes employ the finite difference method to solve Maxwell's equations. MAFIA is a three-dimensional problem solver and uses square patches to approximate the inner surface of a cavity. URMEL and URMEL-T are two-dimensional problem solvers and use rectangular and triangular meshes, respectively. URMEL-T and MAFIA can handle problems with arbitrary dielectric materials located inside the boundary. The cavity employs a circularly cylindrical ceramic window to limit the vacuum to the beam pipe. The ceramic window used in the modeling will have a wall thickness of 0.9 cm. This wall thickness is not negligible in determining the resonant frequencies of the cavity. In the following, results of two- and three-dimensional modeling of the cavities using the URMEL-T and MAFIA codes are reported

  17. Characterization of ParTI Phoswiches Using Charged Pion Beams

    Science.gov (United States)

    Churchman, Emily; Zarrella, Andrew; Youngs, Michael; Yennello, Sherry

    2017-09-01

    The Partial Truncated Icosahedron (ParTI) detector array consists of 15 phoswiches. Each phoswich is made of two scintillating components - a thallium-doped cesium iodide (CsI(Tl)) crystal and an EJ-212 scintillating plastic - coupled to a photomultiplier tube. Both materials have different scintillation times and are sensitive to both charged and neutral particles. The type of particle and amount of energy deposited determine the shape of the scintillation pulse as a function of time. By integrating the fast and slow signals of the scintillation pulses, a ``Fast vs. Slow Integration'' plot can be created that produces particle identification lines based on the energy deposited in the scintillating materials. Four of these phoswiches were taken to the Paul Scherrer Institute (PSI) in Switzerland where π + , π-, and proton beams were scattered onto the phoswiches to demonstrate their particle identification (PID) capabilities. Using digitizers to record the detector response waveforms, pions can also be identified by the characteristic decay pulse of the muon daughters.

  18. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  19. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  20. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Hong-hua; Zhang, Xi; Cao, Pei-guo [Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province (China)

    2011-11-18

    The matrix metalloprotease-1 (MMP-1)/protease-activated receptor-1 (PAR-1) signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC), we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9%) and 58 (68.2%) tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM) stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS) than those with negative ESCC (P = 0.002 and 0.003, respectively). Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR) = 2.836, 95% confidence interval (CI) = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068), MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127), and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883) and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681), MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279), and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881) as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  1. Prognostic value of suPAR and hs-CRP on cardiovascular disease

    DEFF Research Database (Denmark)

    Diederichsen, Marie Zöga; Diederichsen, Søren Zöga; Mickley, Hans

    2018-01-01

    Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP...... have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events...

  2. Profils des enfants infectes par le vih en debut du traitement ...

    African Journals Online (AJOL)

    But : Décrire les profils des enfants infectés par le VIH au début du traitement antirétroviral. Matériels et méthode: Les dossiers des enfants infectés par le VIH dans la région maritime ont été analysés de mai 2008 à février 2010 par le comité thérapeutique. Résultats: Parmi les 96 dossiers analysés, 66,67% venaient du ...

  3. Les dispensées par fantaisie en éducation physique et sportive ...

    African Journals Online (AJOL)

    Cette étude vise à comprendre les raisons avancées par les élèves dispensés par fantaisie des cours d'EPS, pour justifier leur attitude et principalement leur forfait. Une enquête par questionnaire écrit a été menée dans 13 établissements publics de la ville de Porto-Novo au Bénin. Au total, 203 élèves parmi les 771 élèves ...

  4. MODELISATION DE LA CINETIQUE CHIMIQUE DANS LA REDUCTION DES OXYDES D4AZOTE PAR DECHARGE COURONNE.

    OpenAIRE

    MEDJAHDI, Sarah ines

    2015-01-01

    CE TRAVAIL DE recherche rentre dans le cadre général de modélisation de la réduction des oxydes d'azote . l'utilisation des réacteurs a plasma froid non-thermique généré par des décharges couronnes est actuellement l'une des techniques les puis promettre .ses pour la destruction des oxydes d'azote .en effet , le traitement des gaz pollués par les décharges couronnes est notamment rendu possible par la multiplication des décharges Électriques .

  5. Thrombin induces rapid PAR1-mediated non-classical FGF1 release

    International Nuclear Information System (INIS)

    Duarte, Maria; Kolev, Vihren; Soldi, Raffaella; Kirov, Alexander; Graziani, Irene; Oliveira, Silvia Marta; Kacer, Doreen; Friesel, Robert; Maciag, Thomas; Prudovsky, Igor

    2006-01-01

    Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis

  6. Complexation de l'aluminium par des hétéropolyanions lacunaires ...

    African Journals Online (AJOL)

    L'objectif visé par cette étude est la dépollution des eaux à partir de la complexation d'un métal toxique, l'aluminium en solution, par des hétéropolyanions lacunaires (HPA) de type Dawson. Les complexes formés sont récupérés par membrane liquide émulsionnée (MEL).Les résultats de la complex1ation de l'aluminium ...

  7. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Wilde, E.W.; Tilly, L.J.

    1985-02-01

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  8. Monoradiculopathy and secondary segmental instability caused by postoperative pars interarticularis fracture: a case report.

    Science.gov (United States)

    Kaner, Tuncay; Tutkan, Ibrahim

    2009-04-01

    Instability can develop after lumbar spinal surgery. What is also known as secondary segmental instability is one of the important causes of failed back syndrome. In this paper, we described a 45-year-old female patient who was diagnosed with secondary segmental instability caused by left L3 pars interarticularis fracture after a high lumbar disc surgery and was subsequently treated with re-operation. We evaluated the clinical course, diagnosis, and treatment methods for secondary segmental instability caused by postoperative pars interarticularis fracture. Furthermore, we emphasized the importance of preserving the pars interarticularis during upper lumbar disc surgeries in order to avoid a potential stress fracture.

  9. Dynamique de nanobulles et nanoplasmas generes autour de nanoparticules plasmoniques irradiees par des impulsions ultracourtes

    Science.gov (United States)

    Dagallier, Adrien

    L'emergence des lasers a impulsion ultrabreves et des nanotechnologies a revolutionne notre perception et notre maniere d'interagir avec l'infiniment petit. Les gigantesques intensites generees par ces impulsions plus courtes que les temps de relaxation ou de diffusion du milieu irradie induisent de nombreux phenomenes non-lineaires, du doublement de frequence a l'ablation, dans des volumes de dimension caracteristique de l'ordre de la longueur d'onde du laser. En biologie et en medecine, ces phenomenes sont utilises a des fins d'imagerie multiphotonique ou pour detruire des tissus vivants. L'introduction de nanoparticules plasmoniques, qui concentrent le champ electromagnetique incident dans des regions de dimensions nanometriques, jusqu'a une fraction de la longueur d'onde, amplifie les phenomenes non-lineaires tout en offrant un controle beaucoup plus precis de la deposition d'energie, ouvrant la voie a la detection de molecules individuelles en solution et a la nanochirurgie. La nanochirurgie repose principalement sur la formation d'une bulle de vapeur a proximite d'une membrane cellulaire. Cette bulle de vapeur perce la membrane de maniere irreversible,entrainant la cellule a sa mort, ou la perturbe temporairement, ce qui permet d'envisager de faire penetrer dans la cellule des medicaments ou des brins d'ADN pour de la therapie genique. C'est principalement la taille de la bulle qui va decider de l'issue de l'irradiation laser. Il est donc necessaire de controler finement les parametres du laser et la geometrie de la nanoparticule afin d'atteindre l'objectif fixe. Le moyen le plus direct a l'heure actuelle de valider un ensemble de conditions experimentales est de realiser l'experience en laboratoire,ce qui est long et couteux. Les modeles de dynamique de bulle existants ne prennent pas en compte les parametres de l'irradiation et ajustent souvent leurs conditions initiales a partir de leurs mesures experimentales, ce qui limite la portee du modele au cas pour

  10. Influencia de los parámetros de proceso, en el comportamiento del parámetro vibración absoluta en turbinas de vapor.

    Directory of Open Access Journals (Sweden)

    F. de la Torre Silva

    2008-01-01

    Full Text Available Este trabajo muestra el estudio realizado en turbinas de vapor de pequeña capacidad de generación de las centrales termoeléctricas cubanas, relacionadas con la influencia estadística entre parámetros de proceso de la turbina, respecto al parámetro vibración absoluta, medidos en las chumaceras de la turbina. Se utilizan las bases de datos de los sistemas de monitoreado on-line de la turbina. Se exponen las relaciones existentes entre los principales parámetros seleccionados para este estudio.This work show the study in small steam turbine capacity of generation in cubans thermoelectric power station to relative with statistical influence between steam process parameters regarding absolute vibration parameter, in the steam housing measurements. Themselves use database as steam on-line monitoring systems. Expose the existing relation between the principal selection parameters for this study.

  11. Antimicrobial Resistance of Shigella spp. isolated in the State of Pará, Brazil Resistência Antimicrobiana de Shigella spp. isoladas no Estado do Pará

    Directory of Open Access Journals (Sweden)

    Flávia Corrêa Bastos

    2011-10-01

    Full Text Available INTRODUCTION: Shigella spp. are Gram-negative, nonsporulating, rod-shaped bacteria that belong to the family Enterobacteriaceae and are responsible for shigellosis or bacillary dysentery, an important cause of worldwide morbidity and mortality. METHODS: We studied the antibiotic resistance profiles of 122 Shigella spp. strains (81 S. flexneri, 41 S. sonnei, 1 S. boydii isolated from patients (female and male from 0 to 80 years of age presenting diarrhea in different districts of the State of Pará, in the North of Brazil. The antibiotic resistance of the strains, isolated from human fecal samples, was determined by the diffusion disk method and by using the VITEK-2 system. RESULTS: The highest resistance rate found was the resistance rate to tetracycline (93.8%, followed by the resistance rate to chloramphenicol (63.9% and to trimethoprim/sulfamethoxazole (63.1%. Resistance to at least three drugs was more common among S. flexneri than S. sonnei (39.5% vs. 10%. Six (4.9% strains were susceptible to all the antibiotics tested. All strains were susceptible to cefotaxime, ceftazidime, ciprofloxacin, nalidixic acid and nitrofurantoin. CONCLUSIONS: High rates of multidrug resistance in Shigella spp. are a serious public health concern in Brazil. It is extremely important to continuously monitor the antimicrobial resistances of Shigella spp. for effective therapy and control measures against shigellosis.INTRODUÇÃO: Shigella spp. são bactérias Gram-negativas, não esporuladas, em forma de bastonete, pertencentes a família Enterobacteriaceae responsáveis pela shigelose ou disenteria bacilar, uma importante causa de mortalidade e morbidade mundial. MÉTODOS: Foi estudado o perfil de resistência a antimicrobianos de 122 amostras de Shigella spp. (81 S. flexneri, 41 sonnei, 1 S. boydii isoladas de pacientes (sexo feminino e masculino com faixa etária de 0 a 80 anos com distúrbios gastrointestinais em diferentes municípios no Estado do Par

  12. Diffusion-controlled intergranular penetration and embrittlement of copper by liquid bismuth between 300 and 600 Celsius degrees; Penetration intergranulaire fragilisante du cuivre par le bismuth liquide: identification de la cinetique et du mecanisme de type diffusionnel entre 300 et 600 deg

    Energy Technology Data Exchange (ETDEWEB)

    Laporte, V

    2005-02-15

    Hybrid reactors are a new concept for energy production and nuclear waste treatment. Among other requirements, structural materials have to withstand liquid metal embrittlement. This thesis aimed therefore to identify the controlling mechanism for the intergranular embrittlement of copper in contact with liquid bismuth. Scanning electron microscopy, Auger electron spectroscopy, X-ray photoelectron spectroscopy and Rutherford backscattering spectroscopy have been used to analyze fracture surfaces of both copper polycrystals and a copper bicrystal (symmetric tilt boundary 50 degrees <100>). These analyses reveal both parabolic intergranular penetration kinetics and a maximal intergranular bismuth concentration that is less than two monolayers equivalent. These two results allow us to identify grain boundary diffusion as the controlling mechanism for the intergranular penetration of copper by liquid bismuth between 300 and 600 Celsius degrees, showing the absence of perfect grain boundary wetting. (author)

  13. Applications of electrical resistivity measurements to research into the purification of uranium using floating molten zone by electronic bombardment; Applications des mesures de resistivite electrique a l'etude de la purification de l'uranium par fusion de zone flottante par bombardement electronique

    Energy Technology Data Exchange (ETDEWEB)

    Pascal, J L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-02-01

    The purification of uranium has been achieved by zone melting. Because of the high affinity of uranium towards elements such as oxygen, contamination has been avoided by adopting the floating zone technique and by working under high vacuum. The difficulties created by the deformations of uranium rod, which are caused by anisotropy of dilatation of phases {alpha} and {beta} and allotropic transformations {alpha} {r_reversible} {beta} and {beta} {r_reversible} {alpha}, have been overcome by the use of electron bombardment stabilized by feedback. A rough control of the purification was obtained by micrographic examination, microhardness measurements, and tests of secondary recrystallization, allowed us to appreciate the new degree of purity of the uranium obtained. The investigation of the purity degree was pursued by electrical resistivity measurements at 20 deg. K. But one had to take care in the interpretation of those measurements of the anisotropy of the uranium resistivity and the influence of structure on residual resistivity. Those measurements have led us, by determination of single crystal and uranium resistivity, to be able to distinguish between the principal resistivity against axis [100] and [010]. (author) [French] La purification de l'uranium a ete realisee par l'application de la methode dite de la zone fondue. L'uranium etant particulierement reactif vis-a-vis d'elements tels que l'oxygene, les risques de contamination ont ete supprimes en adoptant la technique de la zone flottante et en operant sous vide eleve. Les difficultes creees par les deformations du barreau d'uranium, dues a l'anisotropie de dilatation des phases {alpha} et {beta} et ou passage des deux points de transformation allotropiques {alpha} {r_reversible} {beta} et {beta} {r_reversible} {alpha}, ont pu etre surmontees par l'emploi du chauffage par bombardement electronique, stabilise par un systeme tres simple de contre reaction. Un premier controle de la purification effectue par

  14. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes.......Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...

  15. Outcome of early pars plana vitrectomy in exogenous endophthalmitis

    International Nuclear Information System (INIS)

    Dar, A.J.; Islam, Q.U.; Hanif, M.K.

    2013-01-01

    Objective: To evaluate the role of early pars plana vitrectomy (PPV) in cases of exogenous endophthalmitis in terms of final visual outcome and to determine association between various study variables and final visual outcome. Study Design: Quasi experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi, from Aug 2010 to May 2012. Patients and Methods: Eleven cases of exogenous endophthalmitis (post surgical/post traumatic) were managed surgically through 20 G or 23/25 G complete and early PPV. Vitreous aspirate/explanted intraocular lens (IOL) were sent for culture and sensitivity in all cases. Intra and post operative complications were recorded and best corrected visual acuity (BCVA) at 3 months post operative interval was taken as final visual acuity. Results: Median age of study population was 55 years with male preponderance (64%). Approximately 2/3 rd of study population developed endophthalmitis within 6 weeks of surgery/trauma and 55% of patients were operated within 2 weeks of presentation. Positive culture from vitreous aspirate/IOL explant was obtained in 27% of cases. All the patients had initial BCVA in the range of counting finger (CF) at 2 meter to perception of light (PL+). However, 18% of the patients achieved final BCVA of 6/12 or better and 64% achieved final BCVA of 6/36 or better. Maculopathy (macular scar, macular pucker), corneal decompensation, corneal opacity and raised intraocular pressure were the major complications associated with compromised visual outcome. Conclusion: With the advancement in vitreoretinal surgical techniques and availability of more sophisticated viewing and illumination systems, early and complete vitrectomy for post operative or post traumatic endophthalmitis results in favorable visual outcome and early rehabilitation. (author)

  16. PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis.

    Science.gov (United States)

    Zigler, Maya; Kamiya, Takafumi; Brantley, Emily C; Villares, Gabriel J; Bar-Eli, Menashe

    2011-11-01

    Progression of melanoma is dependent on cross-talk between tumor cells and the adjacent microenvironment. The thrombin receptor, protease-activated receptor-1 (PAR-1), plays a key role in exerting this function during melanoma progression. PAR-1 and its activating factors, which are expressed on tumor cells and the surrounding stroma, induce not only coagulation but also cell signaling, which promotes the metastatic phenotype. Several adhesion molecules, cytokines, growth factors, and proteases have recently been identified as downstream targets of PAR-1 and have been shown to modulate interactions between tumor cells and the microenvironment in the process of melanoma growth and metastasis. Inhibiting such interactions by targeting PAR-1 could potentially be a useful therapeutic modality for melanoma patients. ©2011 AACR.

  17. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  18. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV; Gosselin, L; Qian, P

    2010-01-01

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum

  19. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder

    DEFF Research Database (Denmark)

    Dohn, Line Hammer; Pappot, Helle; Iversen, Benedikte Richter

    2015-01-01

    The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling...... during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative...... or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated...

  20. Contamination des eaux de puits traditionnels par les nitrates sur le ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2014 ... Objectif : La contamination des eaux souterraines par les nitrates est un ... Methodology and Results: the origin of nitrate water from traditional wells of Lobo's watershed was ...... 12 water supply wells, Yucatan, Mexico.

  1. ParFit: A Python-Based Object-Oriented Program for Fitting Molecular Mechanics Parameters to ab Initio Data.

    Science.gov (United States)

    Zahariev, Federico; De Silva, Nuwan; Gordon, Mark S; Windus, Theresa L; Dick-Perez, Marilu

    2017-03-27

    A newly created object-oriented program for automating the process of fitting molecular-mechanics parameters to ab initio data, termed ParFit, is presented. ParFit uses a hybrid of deterministic and stochastic genetic algorithms. ParFit can simultaneously handle several molecular-mechanics parameters in multiple molecules and can also apply symmetric and antisymmetric constraints on the optimized parameters. The simultaneous handling of several molecules enhances the transferability of the fitted parameters. ParFit is written in Python, uses a rich set of standard and nonstandard Python libraries, and can be run in parallel on multicore computer systems. As an example, a series of phosphine oxides, important for metal extraction chemistry, are parametrized using ParFit. ParFit is in an open source program available for free on GitHub ( https://github.com/fzahari/ParFit ).

  2. Study of a system devoted for ultrasonic non destructive testing of complex geometry pieces using smart contacts transducers; Etude d'un systeme de controle par ultrasons des pieces de geometrie conplexe a l'aide de traducteurs contacts intelligents

    Energy Technology Data Exchange (ETDEWEB)

    Chatillon, S

    2000-07-01

    This work is devoted to the enhancement of the ultrasonic non destructive testing in contact of nuclear components with complex geometry. In service inspections of such components performed with conventional probes present limited performances: variations in sensitivity, due to unmatched contact, incorrect characterization of the defect, because of the disorientations of the transducer during its displacement, and uncovered scan area when the geometry of the components disturbs the displacement of the transducer. We propose a new concept of smart transducer to improve the performances of such inspections. The radiating surface is flexible to optimize the sensitivity of the testing. Using the measure of the radiating surface distortion, performed by a specific instrumentation, phased array techniques allow the control of the transmitted beam to optimize the defect localization and characterization. Thus, this system is self-contained. We present the different steps involved to develop this system and its experimental validation. A computing model is extended to predict the field transmitted by a flexible contact transducer. This model is used to optimize the radiating surface of a jointed transducer. A delay law optimizing algorithm is developed to ensure the control of the transmitted beam. At last, a method and the associated instrumentation designed to measure the radiating surface distortion are proposed. Experimental Measures in the through-transmission mode validate the ability of this system to control the field transmitted through complex interfaces. At last, inspections in the pulse-echo mode are performed on a specimen with an irregular profile, representative of a real component inspected on site, and artificial embedded reflectors. Two control configurations are used. In the first one, the transducer is displaced along the surface, in the second one, the transducer is fixed and the region of interest is scanned using beam steering. The results show that

  3. Infection par le VIH chez les patientes atteintes de cancer du sein en ...

    African Journals Online (AJOL)

    L'objectif était de déterminer la prévalence de l'infection à VIH chez les patientes atteintes de cancer du sein et de comparer les caractéristiques anatomocliques et thérapeutiques de ces cancers du sein par rapports aux patientes non infectées par le VIH. Il s'agissait d'une étude rétrospective et analytique comparant les ...

  4. Molecular mechanism of bundle formation by the bacterial actin ParM

    Energy Technology Data Exchange (ETDEWEB)

    Popp, David, E-mail: dpopp@imcb.a-star.edu.sg [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore); Narita, Akihiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Iwasa, Mitsusada [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Maeda, Yuichiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Robinson, Robert C. [Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore)

    2010-01-22

    The actin homolog ParM plays a microtubule-like role in segregating DNA prior to bacterial cell division. Fluorescence and cryo-electron microscopy have shown that ParM forms filament bundles between separating DNA plasmids in vivo. Given the lack of ParM bundling proteins it remains unknown how ParM bundles form at the molecular level. Here we show using time-lapse TIRF microscopy, under in vitro molecular crowding conditions, that ParM-bundle formation consists of two distinct phases. At the onset of polymerization bundle thickness and shape are determined in the form of nuclei of short helically disordered filaments arranged in a liquid-like lattice. These nuclei then undergo an elongation phase whereby they rapidly increase in length. At steady state, ParM bundles fuse into one single large aggregate. This behavior had been predicted by theory but has not been observed for any other cytomotive biopolymer, including F-actin. We employed electron micrographs of ParM rafts, which are 2-D analogs of 3-D bundles, to identify the main molecular interfilament contacts within these suprastructures. The interface between filaments is similar for both parallel and anti-parallel orientations and the distribution of filament polarity is random within a bundle. We suggest that the interfilament interactions are not due to the interactions of specific residues but rather to long-range, counter ion mediated, electrostatic attractive forces. A randomly oriented bundle ensures that the assembly is rigid and that DNA may be captured with equal efficiency at both ends of the bundle via the ParR binding protein.

  5. Etude par simulation hil des performances d'un statcom pour la ...

    African Journals Online (AJOL)

    Ce travail présente l'étude par simulation Hardware In the Loop (HIL) des performances d'un STATCOM pour la stabilisation de la tension délivrée par une génératrice asynchrone triphasée auto excitée dans un réseau autonome. Nous avons combiné l'utilisation du logiciel de simulation LABVIEW et la carte ARDUINO ...

  6. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  7. Compression robuste du signal par la transformée avec les B ...

    African Journals Online (AJOL)

    Par contre, elle diminue de façon considérable pour les b-splincs et les paquets dbndelcttes de Haar. Du point de vue entropie, la compression par bfsplines est bonne que celle de la TCD. Nous donnons ci-dessous un tableau récapitulatif des résultats de quelques méthodes utilisées pour deux signaux EMG. Le facteur de ...

  8. SuPAR predicts postoperative complications and mortality in patients with asymptomatic aortic stenosis

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Eugen-Olsen, Jesper

    2018-01-01

    complications with a HR of 2.7 (95% CI 1.5 to 5.1, P=0.002), per doubling in suPAR. After adjusting for the European System for Cardiac Operative Risk Evaluation or Society of Thoracic Surgeons risk score, suPAR remained associated with postoperative mortality with a HR 3.2 (95% CI 1.2 to 8.6, P=0.025) and 2...

  9. Dosage of cesium 137 in radioactive wastes by the application of sodium tetraphenylborate; Dosage du cesium 137 dans les effluents radioactifs par le tetraphenylborate de sodium

    Energy Technology Data Exchange (ETDEWEB)

    Testemale, G; Girault, J [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-07-01

    A simple technique of the dosage of {sup 137}Cs has been developed. The technique consists in the formation of cesium tetraphenyl borate, followed by a double extraction with isoamyl acetate, and washing of the organic phase. The counting of known parts of the cesium solution assaying of its purity by {gamma} spectrometry enable the determination of the {sup 137}Cs. The yield is about 98 per cent. (authors) [French] Une technique simple du dosage du {sup 137}Cs a ete mise au point. Elle consiste en une double extraction du tetraphenylborate de cesium forme par l'acetate d'isoamyle suivie d'un lavage de la phase organique. Des comptages sur des parties aliquotes de la solution de cesium et un controle de purete par spectrometrie {gamma} permettent la determination de cet element. Rendement: environ 98 pour cent. (auteurs)

  10. Entamoeba histolytica-secreted cysteine proteases induce IL-8 production in human mast cells via a PAR2-independent mechanism.

    Science.gov (United States)

    Lee, Young Ah; Nam, Young Hee; Min, Arim; Kim, Kyeong Ah; Nozaki, Tomoyoshi; Saito-Nakano, Yumiko; Mirelman, David; Shin, Myeong Heon

    2014-01-01

    Entamoeba histolytica is an extracellular tissue parasite causing colitis and occasional liver abscess in humans. E. histolytica-derived secretory products (SPs) contain large amounts of cysteine proteases (CPs), one of the important amoebic virulence factors. Although tissue-residing mast cells play an important role in the mucosal inflammatory response to this pathogen, it is not known whether the SPs induce mast cell activation. In this study, when human mast cells (HMC-1 cells) were stimulated with SPs collected from pathogenic wild-type amoebae, interleukin IL-8 mRNA expression and production were significantly increased compared with cells incubated with medium alone. Inhibition of CP activity in the SPs with heat or the CP inhibitor E64 resulted in significant reduction of IL-8 production. Moreover, SPs obtained from inhibitors of cysteine protease (ICP)-overexpressing amoebae with low CP activity showed weaker stimulatory effects on IL-8 production than the wild-type control. Preincubation of HMC-1 cells with antibodies to human protease-activated receptor 2 (PAR2) did not affect the SP-induced IL-8 production. These results suggest that cysteine proteases in E. histolytica-derived secretory products stimulate mast cells to produce IL-8 via a PAR2-independent mechanism, which contributes to IL-8-mediated tissue inflammatory responses during the early phase of human amoebiasis. © Y.A. Lee et al., published by EDP Sciences, 2014.

  11. Entamoeba histolytica-secreted cysteine proteases induce IL-8 production in human mast cells via a PAR2-independent mechanism

    Directory of Open Access Journals (Sweden)

    Lee Young Ah

    2014-01-01

    Full Text Available Entamoeba histolytica is an extracellular tissue parasite causing colitis and occasional liver abscess in humans. E. histolytica-derived secretory products (SPs contain large amounts of cysteine proteases (CPs, one of the important amoebic virulence factors. Although tissue-residing mast cells play an important role in the mucosal inflammatory response to this pathogen, it is not known whether the SPs induce mast cell activation. In this study, when human mast cells (HMC-1 cells were stimulated with SPs collected from pathogenic wild-type amoebae, interleukin IL-8 mRNA expression and production were significantly increased compared with cells incubated with medium alone. Inhibition of CP activity in the SPs with heat or the CP inhibitor E64 resulted in significant reduction of IL-8 production. Moreover, SPs obtained from inhibitors of cysteine protease (ICP-overexpressing amoebae with low CP activity showed weaker stimulatory effects on IL-8 production than the wild-type control. Preincubation of HMC-1 cells with antibodies to human protease-activated receptor 2 (PAR2 did not affect the SP-induced IL-8 production. These results suggest that cysteine proteases in E. histolytica-derived secretory products stimulate mast cells to produce IL-8 via a PAR2-independent mechanism, which contributes to IL-8-mediated tissue inflammatory responses during the early phase of human amoebiasis.

  12. Hep par-1: a novel immunohistochemical marker for differentiating hepatocellular carcinoma from metastatic carcinoma

    International Nuclear Information System (INIS)

    Hanif, R.

    2014-01-01

    To evaluate the diagnostic utility of Hep par-1 in differentiating hepatocellular carcinoma from metastatic carcinoma taking histopathology as a gold standard. Study Design: Comparative cross-sectional study. Place and Duration of Study: Pathology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from April 2007 to February 2008. Methodology: Hep par-1 immunohistochemical stain was performed on 60 cases of liver carcinoma, 30 cases each of metastatic and hepatocellular carcinoma. Information regarding patient age, gender, sign and symptoms, radiographic findings, histological grade of tumour, and expression of Hep par-1 on hepatocellular and metastatic carcinoma were recorded on proforma sheet. Sensitivity, specificity, positive and negative predictive values, and accuracy of Hep par-1 were calculated using the formulas. Results: Hep par-1 expression was noted in 25 out of 30 cases of hepatocellular carcinoma (83%). Out of 30 cases of metastatic carcinoma, only one case expressed staining in < 5% tumour cells and remaining 29 cases showed no reactivity. The age of the patients with hepatocellular carcinoma ranged from 40 to 76 years with a median age of 60.5 years and 40 - 75 years for metastatic carcinomas with a median age of 57.5 years. Conclusion: Hep par-1 is a reliable immunohistochemical marker for cases of hepatocellular carcinoma (HCC). It can be used along with other markers in morphologically difficult cases when differential diagnosis lies between poorly differentiated HCC and metastatic carcinoma of liver. (author)

  13. Par and IR reflectance, transmittance, and absorptance of four crop canopies

    International Nuclear Information System (INIS)

    Wanjura, D.F.; Hatfield, J.L.

    1986-01-01

    Reflectance, transmittance and absorptance of electromagnetic radiation by cotton, soybeans, grain sorghum, and sunflower was measured at three growth stages in two wavebands (PAR: 0.4 to 0.7 pun and IR: 0.7 to 1.1 yim). As leaf area increased in each crop there were increases in IR reflectance and PAR absorptance and decreases in PAR reflectance and both PAR and IR transmittance. IR radiation was concentrated at the soil surface between rows by reflectance from the sides of canopies when crop cover was less than 80%. Across all crops one parameter, leaf overlap index, explained 81 and 71% of the PAR reflectance and another, crop cover, explained 86 and 94% of IR reflectance from rows and interrows, respectively. Attenuation of PAR radiation through the canopies of cotton and sunflower was similar (K = 0.62 and 0.67) but different from that of soybeans and grain sorghum (K = 0.46 and 0.43) which were the same

  14. Numerical analysis of the influence of PAR unit elevation within a vessel on its performance

    International Nuclear Information System (INIS)

    Kotouč, Miroslav

    2011-01-01

    On the basis of successful validation of the MELCOR code on several experiments from the international OECD/NEA programme THAI, a numerical parametric study has been conducted at NRI Řež evaluating the influence of PAR's vertical position within a vessel on its performance. Simulations were carried out for an Areva PAR unit which was considered to be placed at 5 different elevations in the THAI test vessel, the sixth simulation comprised a model of blower, simulating thus forced convection. The initial conditions were those of the THAI HR-12 test, which was characterized by steam-saturated atmosphere at elevated pressure and temperature. The results show that the overall hydrogen mass recombined monotonically decreases with PAR elevation. This behavior is due to hot, light and hydrogen-lean plume, coming out from the PAR outlet, which, due to buoyancy forces, eventually fills the upper part of the vessel and prevents thus the PAR unit from efficient operation (if the latter is placed near the top). It was also demonstrated that the effect of forced convection is favorable since it breaks the gas stratification and increases thus hydrogen concentration at the PAR inlet. (author)

  15. Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

    International Nuclear Information System (INIS)

    Blanc-Brude, Olivier P.; Archer, Fabienne; Leoni, Patricia; Derian, Claudia; Bolsover, Steven; Laurent, Geoffrey J.; Chambers, Rachel C.

    2005-01-01

    Fibroblast proliferation and procollagen production are central features of tissue repair and fibrosis. In addition to its role in blood clotting, the coagulation cascade proteinase thrombin can contribute to tissue repair by stimulating fibroblasts via proteolytic activation of proteinase-activated receptor-1 (PAR 1 ). During hemostasis, the coagulation cascade proteinase factor X is converted into factor Xa. We have previously shown that factor Xa upregulates fibroblast proliferation via production of autocrine PDGF. In this study, we further examined the effects of factor Xa on fibroblast function and aimed to identify its signaling receptor. We showed that factor Xa stimulates procollagen promoter activity and protein production by human and mouse fibroblasts. This effect was independent of PDGF and thrombin production, but dependent on factor Xa proteolytic activity. We also showed that PAR 1 -deficient mouse fibroblasts did not upregulate procollagen production, mobilize cytosolic calcium, or proliferate in response to factor Xa. Desensitization techniques and PAR 1 -specific agonists and inhibitors were used to demonstrate that PAR 1 mediates factor Xa signaling in human fibroblasts. This is the first report that factor Xa stimulates extracellular matrix production. In contrast with endothelial cells and vascular smooth muscle cells, fibroblasts appear to be the only cell type in which the effects of factor Xa are mediated mainly via PAR 1 and not PAR 2 . These findings are critical for our understanding of tissue repair and fibrotic mechanisms, and for the design of novel approaches to inhibit the profibrotic effects of the coagulation cascade without compromising blood hemostasis

  16. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia

    DEFF Research Database (Denmark)

    Mölkänen, T; Ruotsalainen, E; Thorball, C W

    2011-01-01

    The soluble form of urokinase-type plasminogen activator receptor (suPAR) is a new inflammatory marker. High suPAR levels have been shown to associate with mortality in cancer and in chronic infections like HIV and tuberculosis, but reports on the role of suPAR in acute bacteremic infections...... are scarce. To elucidate the role of suPAR in a common bacteremic infection, the serum suPAR levels in 59 patients with Staphylococcus aureus bacteremia (SAB) were measured using the suPARnostic ELISA assay and associations to 1-month mortality and with deep infection focus were analyzed. On day three, after...... the first positive blood culture for S. aureus, suPAR levels were higher in 19 fatalities (median 12.3; range 5.7-64.6 ng/mL) than in 40 survivors (median 8.4; range 3.7-17.6 ng/mL, p = 0.002). This difference persisted for 10 days. The presence of deep infection focus was not associated with elevated su...

  17. Brief communication: Population variation in human maxillary premolar accessory ridges (MxPAR).

    Science.gov (United States)

    Burnett, Scott E; Hawkey, Diane E; Turner, Christy G

    2010-02-01

    The purpose of this brief communication is to report the results of an analysis of maxillary premolar accessory ridges (MxPAR), a common but understudied accessory ridge that may occur both mesial and distal to the central ridge of the buccal cusp of upper premolars. We developed a new five-grade scoring plaque to better categorize MxPAR variation. Subsequently, we conducted a population analysis of MxPAR frequency in 749 dental casts of South African Indian, American Chinese, Alaskan Eskimo, Tohono O'odham (Papago), Akimel O'odham (Pima), Solomon Islander, South African Bantu, and both American and South African Whites. Northeast Asian and Asian-derived populations exhibited the highest MxPAR frequencies while Indo-European samples (South African Indians, American and South African Whites) exhibited relatively low frequencies. The Solomon Islanders and South African Bantu samples exhibited intermediate frequencies. Our analysis indicates that statistically significant differences in MxPAR frequency exist between major geographic populations. As a result, the MxPAR plaque has now been added to the Arizona State University Dental Anthropology System, an important contribution as maxillary premolar traits are underrepresented in analyses of dental morphology. 2009 Wiley-Liss, Inc.

  18. Examining relational empowerment for elementary school students in a yPAR program.

    Science.gov (United States)

    Langhout, Regina Day; Collins, Charles; Ellison, Erin Rose

    2014-06-01

    This paper joins relational empowerment, youth empowerment, and Bridging Multiple Worlds frameworks to examine forms of relational empowerment for children in two intermediary institutions-school and a youth participatory action research after-school program (yPAR ASP). Participants were twelve children, most of whom were Latina/o and from im/migrant families, enrolled in a yPAR ASP for 2 years. A mixed-method approach was utilized; we analyzed children's interviews, self-defined goals, and their social networks to examine their experiences of relational empowerment. We conclude that children experienced each of the five relational empowerment factors-collaborative competence, bridging social divisions, facilitating others' empowerment, mobilizing networks, and passing on a legacy-in the yPAR ASP setting, and some factors in school. These experiences, however, were more pronounced in the yPAR ASP setting. Additionally, social network analyses revealed that a small but meaningful percentage of actors bridged worlds, especially home and family, but by year 2, also school and the yPAR ASP. Finally, most helpers for school-based goals came from school, but a sizable number came from family, friends, and home worlds, and by year 2, also came from the yPAR ASP. Implications range from theoretical to methodological development, including the use of social network analysis as a tool to descriptively examine relational power in context.

  19. Solution-printed organic semiconductor blends exhibiting transport properties on par with single crystals

    KAUST Repository

    Niazi, Muhammad Rizwan; Li, Ruipeng; Li, Erqiang; Kirmani, Ahmad R.; Abdelsamie, Maged; Wang, Qingxiao; Pan, Wenyang; Payne, Marcia M.; Anthony, John E.; Smilgies, Detlef-M.; Thoroddsen, Sigurdur T; Giannelis, Emmanuel P.; Amassian, Aram

    2015-01-01

    Solution-printed organic semiconductors have emerged in recent years as promising contenders for roll-to-roll manufacturing of electronic and optoelectronic circuits. The stringent performance requirements for organic thin-film transistors (OTFTs) in terms of carrier mobility, switching speed, turn-on voltage and uniformity over large areas require performance currently achieved by organic single-crystal devices, but these suffer from scale-up challenges. Here we present a new method based on blade coating of a blend of conjugated small molecules and amorphous insulating polymers to produce OTFTs with consistently excellent performance characteristics (carrier mobility as high as 6.7 cm2 V−1 s−1, low threshold voltages of<1 V and low subthreshold swings <0.5 V dec−1). Our findings demonstrate that careful control over phase separation and crystallization can yield solution-printed polycrystalline organic semiconductor films with transport properties and other figures of merit on par with their single-crystal counterparts.

  20. Apprendre et maîtriser LabVIEW par ses applications

    CERN Document Server

    Martaj, Nadia

    2014-01-01

    Cet ouvrage traite de l'apprentissage du langage LabVIEW a travers ses applications dans des domaines industriels et academiques, qui permettront a l'ingenieur, technicien ou etudiant d'apprehender rapidement et efficacement ce langage. L'ouvrage commence, dans la partie I, par traiter les differents types de donnees du langage LabVIEW (tableaux, clusters, complexes, chaines de caracteres...), leur manipulation dans des structures d'execution (boucles While, For, la structure Condition, etc.), le langage textuel MathScript, des scripts Matlab, la boite de calcul utilisant la syntaxe du langage C ainsi que les nœuds de propriete qui permettent d'obtenir ou definir la propriete d''un VI. Cette etude est menee a travers des applications d'ingenierie.La partie II est consacree a l'etude de l'outil « Conception de controle et simulation » avec lequel nous pouvons simuler des systemes analogiques ou discrets.La partie III contient differentes applications qui traitent de nombreux themes comme la regulation (diff...

  1. Solution-printed organic semiconductor blends exhibiting transport properties on par with single crystals

    KAUST Repository

    Niazi, Muhammad Rizwan

    2015-11-23

    Solution-printed organic semiconductors have emerged in recent years as promising contenders for roll-to-roll manufacturing of electronic and optoelectronic circuits. The stringent performance requirements for organic thin-film transistors (OTFTs) in terms of carrier mobility, switching speed, turn-on voltage and uniformity over large areas require performance currently achieved by organic single-crystal devices, but these suffer from scale-up challenges. Here we present a new method based on blade coating of a blend of conjugated small molecules and amorphous insulating polymers to produce OTFTs with consistently excellent performance characteristics (carrier mobility as high as 6.7 cm2 V−1 s−1, low threshold voltages of<1 V and low subthreshold swings <0.5 V dec−1). Our findings demonstrate that careful control over phase separation and crystallization can yield solution-printed polycrystalline organic semiconductor films with transport properties and other figures of merit on par with their single-crystal counterparts.

  2. Serological survey of Neospora caninum in dairy herds from Parauapebas, State of Pará

    Directory of Open Access Journals (Sweden)

    Clovis Laurindo Silva

    2015-02-01

    Full Text Available Neospora caninum is a coccidian protozoan that affects cattle worldwide causing economic losses. To survey the frequency of anti-N. caninum antibodies in dairy herds in the municipality of Parauapebas, Southeast of Pará, samples of 465 sera from 45 farms were subjected to indirect immunofluorescence assay (cutoff 1:100. Anti-N. caninum antibodies were found with a frequency of 13,33% with the following titer distribution: 27 (43,55% for titer 100; 14 (22,58% for 200; 16 (25,80% for 400, and 5 (8,07% for 800; no serum titers more than 800 was noted, but at least one positive animal was present in most farms. The highest frequency occurred among females, with no significant difference in frequency between the sexes (Fisher exact test = 0,59, P = 0,99; 2-year-old animals had the highest frequency, although their numbers were lesser than those aged >5 years, with no significant difference in frequency between the age groups (?2 = 2,1, P = 0,71. No significant difference was observed between the frequency and occurrence of abortion (?2 = 2,3, P = 0,13 and frequency and presence of dogs in the farms (?2 = 0,26, P = 0,60. Actions toward health monitoring are recommended to prevent the entry of new sources of N. caninum and to control its spread within herds.

  3. Antimicrobial Resistance of Shigella spp. isolated in the State of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Flávia Corrêa Bastos

    2011-10-01

    Full Text Available INTRODUCTION: Shigella spp. are Gram-negative, nonsporulating, rod-shaped bacteria that belong to the family Enterobacteriaceae and are responsible for shigellosis or bacillary dysentery, an important cause of worldwide morbidity and mortality. METHODS: We studied the antibiotic resistance profiles of 122 Shigella spp. strains (81 S. flexneri, 41 S. sonnei, 1 S. boydii isolated from patients (female and male from 0 to 80 years of age presenting diarrhea in different districts of the State of Pará, in the North of Brazil. The antibiotic resistance of the strains, isolated from human fecal samples, was determined by the diffusion disk method and by using the VITEK-2 system. RESULTS: The highest resistance rate found was the resistance rate to tetracycline (93.8%, followed by the resistance rate to chloramphenicol (63.9% and to trimethoprim/sulfamethoxazole (63.1%. Resistance to at least three drugs was more common among S. flexneri than S. sonnei (39.5% vs. 10%. Six (4.9% strains were susceptible to all the antibiotics tested. All strains were susceptible to cefotaxime, ceftazidime, ciprofloxacin, nalidixic acid and nitrofurantoin. CONCLUSIONS: High rates of multidrug resistance in Shigella spp. are a serious public health concern in Brazil. It is extremely important to continuously monitor the antimicrobial resistances of Shigella spp. for effective therapy and control measures against shigellosis.

  4. Parijs is een meervoud. Adriaan van Dis en de heruitvinding van de Hollander in Parijs

    NARCIS (Netherlands)

    Koffeman, M.N.; Koffeman, Maaike; Montoya, Alicia C.; Smeets, Marc

    2017-01-01

    Parijs, tot halverwege de 20ste eeuw het onbetwiste centrum van de Europese cultuur, heeft van oudsher een grote aantrekkingskracht uitgeoefend op Nederlandse kunstenaars en schrijvers. Velen van hen verbleven er kortere of langere tijd, op zoek naar internationale erkenning. De vrijere seksuele moraal

  5. N.7 notice presented for the Finances Commission, of the budget control and the economical accounts of the Nation on the law project, adopted by the National Assembly after urgency declaration, relative to the energy sector; N.7 avis presente au nom de la commission des Finances, du controle budgetaire et des comptes economiques de la Nation sur le projet de loi, adopte par l'Assemblee Nationale apres declaration d'urgence, relatif au secteur de l'energie

    Energy Technology Data Exchange (ETDEWEB)

    Marini, Ph

    2006-10-15

    This law project concerns the privatization of Gaz de France and the new control of the State on this society. It underlines the necessity of a financial independence of the Commission of the Energy regulation (CRE). (A.L.B.)

  6. Modeling post-wildfire hydrological processes with ParFlow

    Science.gov (United States)

    Escobar, I. S.; Lopez, S. R.; Kinoshita, A. M.

    2017-12-01

    Wildfires alter the natural processes within a watershed, such as surface runoff, evapotranspiration rates, and subsurface water storage. Post-fire hydrologic models are typically one-dimensional, empirically-based models or two-dimensional, conceptually-based models with lumped parameter distributions. These models are useful for modeling and predictions at the watershed outlet; however, do not provide detailed, distributed hydrologic processes at the point scale within the watershed. This research uses ParFlow, a three-dimensional, distributed hydrologic model to simulate post-fire hydrologic processes by representing the spatial and temporal variability of soil burn severity (via hydrophobicity) and vegetation recovery. Using this approach, we are able to evaluate the change in post-fire water components (surface flow, lateral flow, baseflow, and evapotranspiration). This work builds upon previous field and remote sensing analysis conducted for the 2003 Old Fire Burn in Devil Canyon, located in southern California (USA). This model is initially developed for a hillslope defined by a 500 m by 1000 m lateral extent. The subsurface reaches 12.4 m and is assigned a variable cell thickness to explicitly consider soil burn severity throughout the stages of recovery and vegetation regrowth. We consider four slope and eight hydrophobic layer configurations. Evapotranspiration is used as a proxy for vegetation regrowth and is represented by the satellite-based Simplified Surface Energy Balance (SSEBOP) product. The pre- and post-fire surface runoff, subsurface storage, and surface storage interactions are evaluated at the point scale. Results will be used as a basis for developing and fine-tuning a watershed-scale model. Long-term simulations will advance our understanding of post-fire hydrological partitioning between water balance components and the spatial variability of watershed processes, providing improved guidance for post-fire watershed management. In reference

  7. Resistive evolution of current profile in tokamaks, application to the optimization of Tore-supra plasma discharges; Evolution resistive du profil de courant dans les Tokamaks, application a l'optimisation des decharges de Tore Supra

    Energy Technology Data Exchange (ETDEWEB)

    Bregeon, R

    1999-03-01

    In Tokamak plasma physics, current profile shaping has now become a key issue to improve the confinement properties of the plasma discharge. The objective of this work is to study the processes governing the current diffusion when non-inductive current are playing a major role in the discharge. Ultimately, this study aims to identify the key parameters to control the plasma current density profile with external current drive heating systems such as Lower Hybrid Current drive (LHCD) or self generated current drive such as the bootstrap current. Principles of non inductive current drive and heating systems are introduced as well as bootstrap current mechanisms. Then we present the experimental study of plasma parallel electric conductivity to validate existing models. Using these results, the poloidal magnetic field flux diffusion is modelled, using toroidal co-ordinates in order to give an accurate description of the current density profiles evolution. The initial and boundary conditions required for numerical resolution of the diffusion equation are also presented. Finally, we conclude this work with the simulations of two discharges: one with Fast Wave Electron Heating and the second using Lower Hybrid Current Drive. These simulations have multiples aims: validity test of our numerical tool and to show some limits of cylindrical models. Test of electric conductivity and bootstrap current models. To identify the key parameters involved in the current diffusion processes of a high performance plasma discharge on Tore Supra. Such simulations are crucial to determine the amount of non-inductive current required to control and sustain long plasma discharges in steady state. (author)

  8. Non destructive testing of industrial pieces by radiography: quantitative characterization and 3 D reconstruction by the way of a limited number of images; Controle non destructif de pieces industrielles par radiographie: caracterisation quantitative et reconstruction 3D a partir d`un nombre limite de vues

    Energy Technology Data Exchange (ETDEWEB)

    Retraint, F

    1999-12-31

    The non destructive testing of industrial pieces is evaluated on the basis of numerical radiographies.The context of the study is the online control of the fuel rods production. A direct model of a numerical radiography formation is proposed and detailed for an acquisition system consisting of a CCD video connected to a converter screen by an optical system. As this approach does not allow the determination of the measured matter thickness from the X-ray photograph, an approximate model based on realistic approximations of the industrial non destructive testing, has been developed. For the specific cases it is possible to inverse the model and to reach the quantitative information present in the x-ray photograph, in other words, the map of the X-rays measured matter thickness. It becomes then possible to access to the quantitative parameters of the possible defects present in the measured specimen, such as the surface and the bulk. To reach the 3 D information on the defects a 3 D reconstruction method, from 3 X-rays photographs, is proposed.The inverse problem is solved by the non convex energy minimization. (A.L.B.) 109 refs.

  9. Non destructive testing of industrial pieces by radiography: quantitative characterization and 3 D reconstruction by the way of a limited number of images; Controle non destructif de pieces industrielles par radiographie: caracterisation quantitative et reconstruction 3D a partir d`un nombre limite de vues

    Energy Technology Data Exchange (ETDEWEB)

    Retraint, F

    1998-12-31

    The non destructive testing of industrial pieces is evaluated on the basis of numerical radiographies.The context of the study is the online control of the fuel rods production. A direct model of a numerical radiography formation is proposed and detailed for an acquisition system consisting of a CCD video connected to a converter screen by an optical system. As this approach does not allow the determination of the measured matter thickness from the X-ray photograph, an approximate model based on realistic approximations of the industrial non destructive testing, has been developed. For the specific cases it is possible to inverse the model and to reach the quantitative information present in the x-ray photograph, in other words, the map of the X-rays measured matter thickness. It becomes then possible to access to the quantitative parameters of the possible defects present in the measured specimen, such as the surface and the bulk. To reach the 3 D information on the defects a 3 D reconstruction method, from 3 X-rays photographs, is proposed.The inverse problem is solved by the non convex energy minimization. (A.L.B.) 109 refs.

  10. Gas quality prediction in ligno-cellulosic biomass gasification in a co-current gas producer; Prediction de la qualite du gaz en gazeification de la biomasse ligno-cellulosique dans un gazogene a co-courant

    Energy Technology Data Exchange (ETDEWEB)

    Martin, J [Universite Catholique de Louvain (UCL), Faculte des Sciences Appliquees, Dept. de Mecanique, Unite Thermodynamique et Turbomachines, Louvain-la-Neuve (Belgium); Nganhou, J [Universite de Yaounde, Ecole National Superieur Polytechnique de Yaounde, Dept. de Genies Mecanique et Industriel (Cameroon); Amie Assouh, A [Ecole National Superieur Polytechnique de Yaounde, Lab. d' Energetique (Cameroon)

    2008-03-15

    Our research covers the energetic valuation of the biomass for electricity production. As electrical energy production is the main drive behind a modern economy, we wanted to make our contribution to the debate by describing a tried technique, whose use on an industrial scale can still be perfected, failing control over the basic principles that support the gasification processes called upon in this industry. Our study describes gasification, which is a process to transform a solid combustible into a gas combustible. The resulting gas can be used as combustible in an internal combustion motor and produce electricity. Our work interprets the experimental results of gasification tests conducted on an available and functional experimental centre and the ENSPY's Decentralized Energy Production Lab. The work involved developing a tool to appreciate the results of the gasification of the ligneous biomass from the stoichiometric composition of the combustible to be gasified and the chemical and mathematical bases of the gasification process. It is an investigation with a view to elaborating a mathematical model based on the concept of compatibility. Its original lies in the quality prediction method for the gas obtained through the gasification of a biomass whose chemical composition is known. (authors)

  11. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily K.

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  12. RESOLUTION DU PROBLEME DE PREDICTION LINEAIRE PAR LA METHODE ULV. APPLICATION AU SIGNAL FID

    Directory of Open Access Journals (Sweden)

    M KHELIF

    2003-06-01

    Full Text Available Dans le cadre de la spectroscopie RMN, notre objectif est de déterminer le spectre d'absorption du signal de précession libre FID par la méthode de prédiction linéaire (PL. Ceci revient à résoudre le problème de prédiction linéaire en exploitant la méthode de corrélation par l'utilisation de la décomposition en valeurs singulières SVD pour l'inversion de la matrice de corrélation. Or, cette technique est la source d'un certain nombre de problèmes lorsque le signal est noyé dans du bruit. Aussi sera-t-elle coûteuse en temps lorsque les dimensions de la matrice de corrélation sont importantes. Afin de résoudre ce problème, nous exploitons les propriétés d'une nouvelle technique dérivée de la SVD, la décomposition ULV pour minimiser le coût du traitement et assurer une inversion correcte de la matrice de corrélation. Dans ce but, nous déterminons le spectre d'absorption par la technique ULV et nous le comparons avec le spectre déterminé par la SVD et  la FFT. Nous comparons par la suite la qualité des spectres obtenus par rapport au spectre d'absorption idéal  déterminé par FFT.

  13. Use of the statistical control of processes through checking before treatment realised with the ionization chamber and by electronic portal system of imaging (E.P.I.D.) in intensity modulated radiotherapy (I.M.R.T.); Utilisation de la maitrise statistique des processus dans le cadre des controles avant traitement realises avec la chambre d'ionisation et par systeme d'imagerie portale electronique (EPID) en radiotherapie conformationnelle avec modulation d'intensite (RCMI)

    Energy Technology Data Exchange (ETDEWEB)

    Villani, N.; Gerard, K.; Noel, A. [Nancy univ., Lab. de Recherche en Radiophysique, CRAN UMR 7039, CNRS, Centre Alexis-Vautrin, 54 - Vandoeuvre-les-Nancy (France); Marchesi, V.; Huger, S. [Centre Alexis-Vautrin, Unite de Radiophysique Medicale, 54 - Vandoeuvre-les-Nancy (France)

    2009-10-15

    The expected results are to demonstrate that it is possible to reduce the times devoted to the pre-treatment controls, while keeping an optimal safety, on substituting the measures of the ionization chamber by this one of the electronic portal imaging device (E.P.I.D.). (N.C.)

  14. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  15. Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-host-range IncA/C plasmid.

    Science.gov (United States)

    Lang, Kevin S; Danzeisen, Jessica L; Xu, Wayne; Johnson, Timothy J

    2012-05-01

    The multidrug resistance-encoding plasmids belonging to the IncA/C incompatibility group have recently emerged among Escherichia coli and Salmonella enterica strains in the United States. These plasmids have a unique genetic structure compared to other enterobacterial plasmid types, a broad host range, and a propensity to acquire large numbers of antimicrobial resistance genes via their accessory regions. Using E. coli strain DH5α harboring the prototype IncA/C plasmid pAR060302, we sought to define the baseline transcriptome of IncA/C plasmids under laboratory growth and in the face of selective pressure. The effects of ampicillin, florfenicol, or streptomycin exposure were compared to those on cells left untreated at logarithmic phase using Illumina platform-based RNA sequencing (RNA-Seq). Under growth in Luria-Bertani broth lacking antibiotics, much of the backbone of pAR060302 was transcriptionally inactive, including its putative transfer regions. A few plasmid backbone genes of interest were highly transcribed, including genes of a putative toxin-antitoxin system and an H-NS-like transcriptional regulator. In contrast, numerous genes within the accessory regions of pAR060302 were highly transcribed, including the resistance genes floR, bla(CMY-2), aadA, and aacA. Treatment with ampicillin or streptomycin resulted in no genes being differentially expressed compared to controls lacking antibiotics, suggesting that many of the resistance-associated genes are not differentially expressed due to exposure to these antibiotics. In contrast, florfenicol treatment resulted in the upregulation of floR and numerous chromosomal genes. Overall, the transcriptome mapping of pAR060302 suggests that it mitigates the fitness costs of carrying resistance-associated genes through global regulation with its transcriptional regulators.

  16. Cambios en el tono muscular en dos niños con parálisis cerebral espástica mediante la hipoterapia: reporte de casos

    Directory of Open Access Journals (Sweden)

    Yasmín Andrea Rodríguez Laiseca

    2015-06-01

    Full Text Available Introducción: Estudios previos han demostrado que la hipoterapia como terapia complementaria mejora la función motora gruesa en niños con parálisis cerebral. Sin embargo la evidencia no es concluyente. Objetivo: Determinar los cambios en el tono muscular de dos pacientes con parálisis cerebral tipo cuadriparesia espástica mediante la hipoterapia. Descripción del caso: El estudio se llevó a cabo con dos sujetos de género masculino de dos años de edad, con diagnóstico de parálisis cerebral tipo cuadriparesia espástica, nivel V según la escala Gross Motor Function Clasification System (GMFCS. Los niños realizaron 27 sesiones de hipoterapia distribuidas de la siguiente manera: 3 sesiones de acoplamiento en hipoterapia en la primera semana y 24  sesiones de monta terapéutica con una frecuencia de tres veces por semana y una intensidad de 20 minutos por sesión. Se llevó a cabo la valoración del tono muscular mediante la escala de Ashworth modificada (MAS de la siguiente forma: una inicial, dos de control, cuatro post-monta, una final tras 9 semanas de tratamiento continuo y tres mediciones más en la semana uno, dos y tres de inactividad terapéutica. Resultados y discusión: La hipoterapia demostró efecto modulador sobre el tono muscular de los dos sujetos finalizadas las 27 sesiones de hipoterapia, pero este se pierde progresivamente durante el periodo de inactividad terapéutica. Por lo tanto se confirma que esta técnica puede ser una estrategia de tratamiento para el manejo de la espasticidad en pacientes con parálisis cerebral, siempre y cuando se aplique continuamente.

  17. Foix-Chavany-Marie syndrome caused by a disconnection between the right pars opercularis of the inferior frontal gyrus and the supplementary motor area.

    Science.gov (United States)

    Martino, Juan; de Lucas, Enrique Marco; Ibáñez-Plágaro, Francisco Javier; Valle-Folgueral, José Manuel; Vázquez-Barquero, Alfonso

    2012-11-01

    Foix-Chavany-Marie syndrome (FCMS) is a rare type of suprabulbar palsy characterized by an automatic-voluntary dissociation of the orofacial musculature. Here, the authors report an original case of FCMS that occurred intraoperatively while resecting the pars opercularis of the inferior frontal gyrus. This 25-year-old right-handed man with an incidentally diagnosed right frontotemporoinsular tumor underwent surgery using an asleep-awake-asleep technique with direct cortical and subcortical electrical stimulation and a transopercular approach to the insula. While resecting the anterior part of the pars opercularis the patient suffered sudden anarthria and bilateral facial weakness. He was unable to speak or show his teeth on command, but he was able to voluntarily move his upper and lower limbs. This syndrome lasted for 8 days. Postoperative diffusion tensor imaging tractography revealed that connections of the pars opercularis of the right inferior frontal gyrus with the frontal aslant tract (FAT) and arcuate fasciculus (AF) were damaged. This case supplies evidence for localizing the structural substrate of FCMS. It was possible, for the first time in the literature, to accurately correlate the occurrence of FCMS to the resection of connections between the FAT and AF, and the right pars opercularis of the inferior frontal gyrus. The FAT has been recently described, but it may be an important connection to mediate supplementary motor area control of orofacial movement. The present case also contributes to our knowledge of complication avoidance in operculoinsular surgery. A transopercular approach to insuloopercular gliomas can generate FCMS, especially in cases of previous contralateral lesions. The prognosis is favorable, but the patient should be informed of this particular hazard, and the surgeon should anticipate the surgical strategy in case the syndrome occurs intraoperatively in an awake patient.

  18. CFD modelling of hydrogen stratification in enclosures: Model validation and application to PAR performance

    Energy Technology Data Exchange (ETDEWEB)

    Hoyes, J.R., E-mail: james.hoyes@hsl.gsi.gov.uk; Ivings, M.J.

    2016-12-15

    Highlights: • The ability of CFD to predict hydrogen stratification phenomena is investigated. • Contrary to expectation, simulations on tetrahedral meshes under-predict mixing. • Simulations on structured meshes give good agreement with experimental data. • CFD model used to investigate the effects of stratification on PAR performance. • Results show stratification can have a significant effect on PAR performance. - Abstract: Computational Fluid Dynamics (CFD) models are maturing into useful tools for supporting safety analyses. This paper investigates the capabilities of CFD models for predicting hydrogen stratification in a containment vessel using data from the NEA/OECD SETH2 MISTRA experiments. Further simulations are then carried out to illustrate the qualitative effects of hydrogen stratification on the performance of Passive Autocatalytic Recombiner (PAR) units. The MISTRA experiments have well-defined initial and boundary conditions which makes them well suited for use in a validation study. Results are presented for the sensitivity to mesh resolution and mesh type. Whilst the predictions are shown to be largely insensitive to the mesh resolution they are surprisingly sensitive to the mesh type. In particular, tetrahedral meshes are found to induce small unphysical convection currents that result in molecular diffusion and turbulent mixing being under-predicted. This behaviour is not unique to the CFD model used here (ANSYS CFX) and furthermore, it may affect simulations run on other non-aligned meshes (meshes that are not aligned perpendicular to gravity), including non-aligned structured meshes. Following existing best practice guidelines can help to identify potential unphysical predictions, but as an additional precaution consideration should be given to using gravity-aligned meshes for modelling stratified flows. CFD simulations of hydrogen recombination in the Becker Technologies THAI facility are presented with high and low PAR positions

  19. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  20. Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals

    DEFF Research Database (Denmark)

    Langkilde, Anne A; Hansen, Tine Willum; Ladelund, Steen

    2011-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable plasma biomarker associated with inflammation and disease. This study tested the association between suPAR levels and incident respiratory, gastrointestinal or other types of cancer in initially cancer-free individuals...... with respiratory, gastrointestinal and other cancer types, respectively.CONCLUSIONS: Elevated suPAR levels were associated with increased risk of incident respiratory cancer and other types of cancer, but not gastrointestinal cancers, independently of established risk factors, CRP and leukocyte numbers. Impact.......RESULTS: suPAR levels ranged from 0.6-22 ng/ml, and median suPAR level was 4.01 ng/ml. 1 ng/ml increase in baseline suPAR was associated with adjusted hazard ratios (HR) of 1.61 (95% CI: 1.23-2.11, P

  1. Quality index of the surface water of Amazonian rivers in industrial areas in Pará, Brazil.

    Science.gov (United States)

    Medeiros, Adaelson Campelo; Faial, Kleber Raimundo Freitas; do Carmo Freitas Faial, Kelson; da Silva Lopes, Iris Danielly; de Oliveira Lima, Marcelo; Guimarães, Raphael Mendonça; Mendonça, Neyson Martins

    2017-10-15

    In this study was to evaluate the waters quality of the Murucupi River, located in urban agglomerate area and intense industrial activity in Barcarena City, Pará State. The Arapiranga River in Abaetetuba City was used as control area (Background), next to Barcarena. Was used the Water Quality Index (WQI) based on nine variables analized. Waters quality of the Arapiranga and Murucupi rivers were regular to good and bad to good, respectively. Anthropogenic influence on the Murucupi River was higher, mainly by the disposal of domestic effluents from the urban agglomerate and of the industrial waste tailing basins upstream of this river. Due to its less inhabited environment and further away from the area urban and industrial, the Arapiranga River was more preserved. Waters pollution of around these area is increasingly intense, and restricted its uses for various purposes. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.

    Directory of Open Access Journals (Sweden)

    Kara R Barber

    2017-02-01

    Full Text Available Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role of many proteins at the active zones in synaptic communication is relatively well studied, very little is known about how these proteins are transported to the synapses. For example, are there distinct mechanisms for the transport of active zone components or are they all transported in the same transport vesicle? Is active zone protein transport regulated? In this report we show that overexpression of Par-1/MARK kinase, a protein whose misregulation has been implicated in Autism spectrum disorders (ASDs and neurodegenerative disorders, lead to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions. Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau. Thus, our study strongly suggests that there are distinct mechanisms that transport components of active zones and that they are tightly regulated.

  3. Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb.

    Science.gov (United States)

    Schenk, Heiko; Müller-Deile, Janina; Schmitt, Roland; Bräsen, Jan Hinrich; Haller, Hermann; Schiffer, Mario

    2017-12-01

    Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied. Efficiency of total plasma exchange to remove suPAR was determined. CytoSorb hemoadsorption caused a 27.33% reduction of the suPAR level in a single treatment, whereas total plasma exchange showed a suPAR level reduction of 25.12% (n = 3; 95% confidence interval, 0.2777-0.8090; P < 0.01), which may indicate therapeutic potential in the treatment of primary FSGS and its recurrence in a kidney transplant. © 2017 Wiley Periodicals, Inc.

  4. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    International Nuclear Information System (INIS)

    Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Boisen, Anja; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Hwang, Ing-Shouh; Eugen-Olsen, Jesper

    2013-01-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform. (paper)

  5. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.

  6. "It was like reading a detective novel": Using PAR to work together for culture change.

    Science.gov (United States)

    Fortune, Darla; McKeown, Janet; Dupuis, Sherry; de Witt, Lorna

    2015-08-01

    Participatory action research (PAR), with its focus on engagement and collaboration, is uniquely suited to enhancing culture change initiatives in dementia care. Yet, there is limited literature of its application to culture change approaches in care settings, and even less in dementia specific care contexts. To address these gaps in the literature, the purpose of this paper is to examine the complexities of a PAR project aimed at changing the culture of dementia care in two diverse dementia care settings, including a long term care (LTC) and community care setting. Drawing from data gathered throughout the PAR process, we unpack the challenges experienced by participants working together to guide culture change within their respective care settings. These challenges include: overextending selves through culture change participation; fluctuating group membership; feeling uncertainty, confusion and apprehension about the process; frustratingly slow process; and seeking diverse group representation in decision making. We also highlight the potential for appreciative inquiry (AI) to be integrated with PAR to guide a process whereby participants involved in culture change initiatives can develop strategies to mitigate challenges they experience. We view the challenges and strategies shared here as being constructive to would-be culture change agents and hope this paper will move others to consider the use of PAR when engaging in culture change initiatives. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

    Science.gov (United States)

    Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

    2011-01-01

    Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

  8. Efficacité d'un exutoire de dévalaison pour smolts de saumon atlantique (Salmo salar L. et comportement des poissons au niveau de l'aménagement hydroélectrique de Bedous sur le gave d'Aspe étudiés par la technique de marquage-recapture et par radiotélémétrie

    Directory of Open Access Journals (Sweden)

    CHANSEAU M.

    1999-04-01

    Full Text Available Deux expérimentations ont été conduites en 1995 et 1998 au niveau de la prise d'eau de l'aménagement hydroélectrique de Bedous sur le Gave d'Aspe afin de tester l'efficacité d'un exutoire de dévalaison pour smolts de saumon atlantique (Salmo salar L.. Le dispositif de dévalaison est situé en rive droite à proximité immédiate du plan des grilles. Le débit moyen alimentant l'exutoire a varié au cours de l'étude de 0,4 m3/s à 1,2 m3/s ce qui correspond à 1,6 % à 4,3 % du débit turbiné. Lefficacité du dispositif a été évaluée grâce à la technique de marquage-recapture. Le comportement des smolts dans le canal d'amenée a été suivi par radiotélémétrie. L'efficacité de l'exutoire (moyenne : 17 % s'est révélée très faible en 1995 â cause de conditions hydrauliques défavorables. Un mur déflecteur a été mis en place en 1997 afin de modifier l'écoulement dans le canal et améliorer le guidage des poissons vers l'entrée du dispositif de dévalaison. L'efficacité de l'exutoire est passée à 55 %. Le comportement des poissons à l'amont immédiat des grilles de prise d'eau est très dépendant des conditions hydrodynamiques dans le canal d'amenée. L'efficacité de l'exutoire semble croître avec la longueur des poissons, la proportion des classes de taille inférieures à 19 cm étant plus faible sur les poissons piégés que sur les poissons lâchés. Cette sélection est très certainement liée à l'espacement relativement important des barreaux des grilles de la prise d'eau (30 mm qui malgré le courant tangentiel au plan de grilles demeurent plus perméables aux individus les plus petits. L'éclairage de l'entrée de l'exutoire ne paraît pas avoir d'influence sur les déplacements des poissons radiomarqués dans le canal d'amenée, le facteur hydraulique étant prépondérant. Il modifie cependant les rythmes de passage des poissons par l'exutoire.

  9. Access control and interlock system at the Advanced Photon Source

    International Nuclear Information System (INIS)

    Forrestal, J.; Hogrefe, R.; Knott, M.; McDowell, W.; Reigle, D.; Solita, L.; Koldenhoven, R.; Haid, D.

    1997-01-01

    The Advanced Photon Source (APS) consists of a linac, position accumulator ring (PAR), booster synchrotron, storage ring, and up to 70 experimental beamlines. The Access Control and Interlock System (ACIS) utilizes redundant programmable logic controllers (PLCs) and a third hard-wired chain to protect personnel from prompt radiation generated by the linac, PAR, synchrotron, and storage ring. This paper describes the ACIS's design philosophy, configuration, hardware, functionality, validation requirements, and operational experience

  10. Microsporidia parásitos de larvas de mosquito de la Costa Pacífica del Chocó

    Directory of Open Access Journals (Sweden)

    Zuluaga Juan S.

    1993-12-01

    Full Text Available Two genera of Microsporidia were found infecting mosquito larvae in three localities on the Pacific coast of Choco. Vavraia sp. (Microsporida: Pleistophoridae was found in larvae of Wyeomyia circumcincta, W. simmsi and Anopheles albimanus collected from plants of the Bromeliacea family in Arusí y Joví. Amblyospora sp. (Microsporida: Amblyosporidae was found parasitizingAedes angustivittatuslarvae COllectedfrom a terrestrial breeding pond in the locality of Nuqur. Morphology of the spores of the two parasites under light microscopy is described, as well as preliminary data on host range when exposed to laboratory rearad Aedes aegypti, Culex quinquefasciatus and Anopheles albimanus. Their rola in mosquito control is discussed.Se reportan dos géneros de microsporidia que parasitan larvas de mosquitos en criaderos naturales de tres localidades en la costa Pacffica Chocoana. Vavraia sp. (Microsporida: Pleistophoridae parásita larvas de Wyeomyia circumcincta, de Wyeomya simmsi y de Anopheles neivai, recolectadas en las rosetas de especies de la familia Bromeliaceae en las localidades de Arusí y Joví. Amblyospora sp. (Microsporida: Amblyosporidae parásita larvas deAedes angustivittatusde criaderos terrestres semipermanentes en la localidad de Nuquí. Se describe la morfología de estos dos microsporidia al microscopio óptico. Estudios preliminares de infección en larvas de Aedes aegypti, Culex quinquefasciatus yAnopheles albimanus, criadas en laboratorio, indican que Vavraia sp. infecta las tres especies, con preferencia a Culex quinquefasciatus. Las larvas expuestas a esporas de Amblyospora sp. no presentaron infección. Se discute el posible papel de estos dos géneros en el control de las poblaciones de mosquitos.

  11. Characteristics of membranes which are suitable for isotopic separation by gaseous diffusion; Caracteristiques des barrieres utilisables pour la separation isotopique par diffusion gazeuse

    Energy Technology Data Exchange (ETDEWEB)

    Massignon, D [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    In this article we shall briefly describe how results obtained from the experimental analysis of the structure of membranes can be used on the one hand for determining this structure and on the other hand as a result for example of the detection of too many large pores or micro fissures and the existence of leaks at the joints, for eliminating membranes which can not be used industrially. Here we shall only consider the utilisation of information given by measurement of the specific permeability G{sub 0}, the pore radius for the molecular (diffusion) regime r{sub mol.}, the pore radius for the viscous diffusion regime the pore radius for the intermediate stage of diffusion, r{sub wicke}, the pore radius r{sub sep.} which is used for determining the actual separation, the distribution of the pore radius defined by mercury symmetry, the B.E.T. and central X ray diffusion. First of all we shall give the definition which is adopted in practice for these empirical values, which can be adapted for a rapid analysis of the quality of membranes by comparing them with the same measurements carried out on standard porous samples. In a second section we show in a few cases which have occurred in routine measurement how by comparison it is possible to eliminate membranes which do not have a suitable structure. (author) [French] Dans cet expose, nous allons montrer sommairement comment les resultats donnes par les methodes experimentales de controle de la structure des barrieres peuvent, d'une part, conduire a une certaine representation de cette structure et, d'autre part, permettre d'eliminer les barrieres non utilisables industriellement en detectant par exemple les trop nombreux gros pores ou microfissures et l'existence de fuites aux joints. Nous nous limiterons ici a l'exploitation des renseignements donnes par la permeabilite specifique G{sub 0}, le rayon de pore r{sub mol.} effectif en regime moleculaire, le rayon de pore r{sub visq.} effectif en regime visqueux, le

  12. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes

    Science.gov (United States)

    Magnussen, Synnøve; Hadler-Olsen, Elin; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja E.; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg

    2014-01-01

    Background The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells’ expression level of uPAR affected the activity of gelatinolytic enzymes. Methods The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM) proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography. Results We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. Conclusions Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the

  13. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  14. Paraplégie compliquant une plaie abdominale antérieure par arme blanche

    Science.gov (United States)

    Elahmadi, Brahim; Awab, Almahdi; El Moussaoui, Rachid; El Hijri, Ahmed; Azzouzi, Abderrahim; Alilou, Mustapha

    2015-01-01

    Les traumatismes médullaires sont des complications rares des plaies abdominales antérieures par arme blanche. Son diagnostic est difficile parfois retardé. L'imagerie par résonance magnétique reste l'examen de choix. Le traitement dépend du tableau clinique et de la gravité de la souffrance médullaire. Le pronostic est corrélé à l’étendue et à la nature de la lésion médullaire. Nous rapportons un cas exceptionnel d'un traumatisme médullaire chez une patiente victime d'une plaie abdominale antérieure par arme blanche. PMID:25995808

  15. Evaluation of Passive Autocatalytic Recombiner (PAR) Implementation in a Konvoi NPP Containment Type

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Alonso, E.; Papini, D.; Jimenez, G.

    2015-07-01

    The evaluation of Passive Autocatalytic Recombiner (PAR) implementation has been developed under the methodology extracted from the IAEA document, analysing the size, location and number of the PARs capable to minimize the combustion risk, which arises from a hydrogen release generated during a severe accident and its distribution in containment building. A detailed three-dimensional model of Konvoi (PWR) containment with GOTHIC 8.1 code was used for the simulations. The hydrogen preferential pathways and the accumulation points were studied and identified on the basis of a base case scenario without any mitigation measure. The PAR configuration offers an improvement in the chosen accidental scenario; decreasing the possibility of hydrogen combustion and leading to concentration values below the flammability limit (hydrogen concentration below 7%), in all the containment compartments at the end of the transient. Furthermore, from the analysis, it is concluded that the time required to reach hydrogen concentrations below the combustion limit is considerably reduced. (Author)

  16. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L

    2013-01-01

    BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects...... of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI......) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis....

  17. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects

  18. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  19. Accouchement par césarienne et mortalité maternelle du postpartum

    OpenAIRE

    Deneux-Tharaux , Catherine; Carmona , Elodie; Bouvier-Colle , Marie-Hélène; Bréart , Gérard

    2006-01-01

    Objectifs Une augmentation continue du taux d'accouchements par césarienne (CS)est observée dans la plupart des pays depuis 20 ans. Cette évolution a suscité l'émergence d'un débat controversé sur les risques et les bénéfices associés à la CS. L'objectif de cette étude était d'estimer le risque de mort maternelle du postpartum lié directement à la CS par comparaison à l'accouchement par voie basse, globalement et en distinguant les CS pre- ou intra- partum . Méthode Etude cas/témoins. Les cas...

  20. Modification de la surface du cuivre par implantation ionique par source plasma (IISP): applications à l’érosion cathodique dans les systèmes à arcs

    OpenAIRE

    Roy, F

    2006-01-01

    L’érosion cathodique est un phénomène bien connu qui limite la durée de vie de l’électrode négative dans les systèmes à arcs. Dans le présent mémoire, nous avons tenté de voir si la formation de précipités nanométriques d’oxyde de cuivre pouvait réduire l’érosion cathodique nécessaire au maintien de l’arc en mode thermo-champ (T-F). Les dits précipités ont été produits par implantation ionique par source plasma (IISP). Avec l’aide de techniques de caractérisation telle que la microscopie à fo...

  1. Perspectives de développement de la production industrielle d'hydrogène par électrolyse alcaline avancée Development Outlook for Industrial Hydrogen Production by Advanced Alkaline Electrolysis

    Directory of Open Access Journals (Sweden)

    Derive C.

    2006-11-01

    Full Text Available Dans les conditions du développement du programme nucléaire français qui permettent une production d'électricité à un coût intéressant en heures creuses, la production d'hydrogène par électrolyse de l'eau peut être envisagée à moyen terme en compétition avec les autres procédés de fabrication d'hydrogène tels que le reformage de gaz naturel. Dans le cadre de leur coopération, Électricité de France (EDF et le Gaz de France (GDF conduisent, depuis 1976, un programme de recherches et développement sur la production d'hydrogène par électrolyse alcaline de l'eau ayant pour but, par comparaison avec des installations existantes, de réduire le coût d'investissement et de conserver un rendement identique. Les études préalables ont montré que ces objectifs pouvaient être atteints par une électrolyse avancée avec élévation de la densité de courant et de la température. Ces contraintes techniques ont conduit EDF et le GDF à lancer des études sur la tenue chimique et la résistance mécanique des matériaux, sur une sélection de composants de cellules adaptés et sur l'amélioration de la conception d'ensemble des installations. Les deux groupements industriels français - pilotés par Alsthom-Atlantique et Creusot-Loire - associés à ces travaux depuis 1979, ont fixé les conditions de fonctionnement suivantes : - électrolyte à base de potasse (40 % en masse; - température de 120 et 160°C; - pression de 30 et 70 bar. Dans un premier temps, les constructeurs ont réalisé une étude technico-économique sur la production massive d'hydrogène à partir d'usines de puissance d'environ 300 MWe, fourni les plans de détail d'une installation pilote de 2 MWe et entrepris la qualification de leurs choix technologiques sur des boucles-prototypes de 25-30 kWe. Afin de valider plus complètement les choix retenus et d'approfondir les problèmes d'extrapolation à des électrolyseurs de grande taille, les essais sur boucles

  2. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

    Science.gov (United States)

    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  3. First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Science.gov (United States)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene; Christensen, Camilla; Madsen, Jacob; Nielsen, Carsten H.; Thurison, Tine; Klausen, Thomas Levin; Holm, Søren; Loft, Annika; Berthelsen, Anne Kiil; Ploug, Michael; Pappot, Helle; Brasso, Klaus; Kroman, Niels; Højgaard, Liselotte; Kjaer, Andreas

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with 64Cu for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of 64Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment with laboratory blood screening tests was performed before and after PET ligand injection. In a subgroup of the patients, the in vivo stability of our targeted PET ligand was determined in collected blood and urine. No adverse or clinically detectable side effects in any of the 10 patients were found. The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human study therefore provides promising evidence for safe use of 64Cu-DOTA-AE105 for uPAR PET imaging in cancer patients. PMID:26516369

  4. Sucralfate modulates uPAR and EGFR expression in an experimental rat model of cervicitis.

    Science.gov (United States)

    Mannari, C; Santi, S; Migliori, M; Filippi, C; Origlia, N; Sansò, M; Boldrini, E; Giovannini, L

    2008-01-01

    Sucralfate is a drug used in the treatment of gastric and duodenal ulcer; it is cytoprotective and able to increase the bioavailability of several growth factors, modulating the wound healing process. In this study we tested the possible therapeutic effect of Sucralfate in the treatment of ulcerative lesions occurring in uterine cervix; to investigate such effect we used an experimental rat model of cervicitis in which the uPAR and EGFR expression were evaluated. Cervicitis was induced in wild and ovariectomized Wistar female rats by an acetic acid-soaked tampon. The animals were divided into two main groups (4 and 7 days) and Sucralfate was administered topically until the day they were sacrificed. In order to distinguish physiological and drug-induced healing, quantitative and qualitative uPAR and EGFR expression were evaluated by using Western blot and Immunohistochemistry techniques. Western blot analysis demonstrated an increased expression of both receptors after 4 days from wounding in wild and ovariectomized animals. In particular in ovariectomized animals the expression of uPAR and EGFR increased after 4 days while it reduced following the administration of Sucralfate. In wild rats the same was observed for uPAR expression, while EGFR was different; in fact, its expression increased significantly at day 4 in the animals treated with the drug and only at day 7 in those untreated. Immunohistochemistry highlighted a noteworthy epithelial colocalization of EGFR and uPAR after 4 days in the animals treated with Sucralfate. We conclude that Sucralfate can promote the healing of ulcerative cervicitis and moreover, it reduces the normal healing time because of its modulatory property on uPAR and EGFR expression.

  5. Potential trajectories of the upcoming forest trading mechanism in Pará State, Brazilian Amazon.

    Directory of Open Access Journals (Sweden)

    Brenda Brito

    Full Text Available In 2012, the Brazilian government revised the federal Forest Code that governs the use of forest resources on rural properties. The revisions included a forest trading mechanism whereby landowners who deforested more than what is legally allowed before 2008 could absolve their deforestation "debts" by purchasing Environmental Reserve Quotas (CRA from landowners who conserved more forest than legally required. CRA holds promise as a tool to complement command-and-control initiatives to reduce deforestation and incentivize restoration. However, the success of this instrument depends on how its implementation is governed. This study builds on a few recent assessments of the potential of the CRA in Brazil-but that are focused on biophysical potential-by assessing how a few key implementation decisions may influence the CRA market development. Specifically, this study estimates how decisions on who can participate will likely influence the potential forest surplus and forest debt for the CRA market, and takes into account governance characteristics relevant to the State of Pará, eastern Amazonia. In particular, the study evaluates the effects in the CRA market eligibility after simulating a validation of properties in the environmental rural registry (CAR and assessing different scenarios surrounding land tenure status of properties. Results show how regulatory decisions on CRA market eligibility will determine the extent to which CRA will serve as a tool to support forest conservation or as a low-cost path to help illegal deforesters to comply with legislation, but with limited additional environmental benefits. The study reviews regulatory options that would reduce the risk of forest oversupply, and thereby increase the additionality of the areas eligible for CRA. Overall, the study demonstrates the importance of including governance as well as biophysical characteristics in assessing the potential of forest trading tools to deliver additional

  6. Potential trajectories of the upcoming forest trading mechanism in Pará State, Brazilian Amazon.

    Science.gov (United States)

    Brito, Brenda

    2017-01-01

    In 2012, the Brazilian government revised the federal Forest Code that governs the use of forest resources on rural properties. The revisions included a forest trading mechanism whereby landowners who deforested more than what is legally allowed before 2008 could absolve their deforestation "debts" by purchasing Environmental Reserve Quotas (CRA) from landowners who conserved more forest than legally required. CRA holds promise as a tool to complement command-and-control initiatives to reduce deforestation and incentivize restoration. However, the success of this instrument depends on how its implementation is governed. This study builds on a few recent assessments of the potential of the CRA in Brazil-but that are focused on biophysical potential-by assessing how a few key implementation decisions may influence the CRA market development. Specifically, this study estimates how decisions on who can participate will likely influence the potential forest surplus and forest debt for the CRA market, and takes into account governance characteristics relevant to the State of Pará, eastern Amazonia. In particular, the study evaluates the effects in the CRA market eligibility after simulating a validation of properties in the environmental rural registry (CAR) and assessing different scenarios surrounding land tenure status of properties. Results show how regulatory decisions on CRA market eligibility will determine the extent to which CRA will serve as a tool to support forest conservation or as a low-cost path to help illegal deforesters to comply with legislation, but with limited additional environmental benefits. The study reviews regulatory options that would reduce the risk of forest oversupply, and thereby increase the additionality of the areas eligible for CRA. Overall, the study demonstrates the importance of including governance as well as biophysical characteristics in assessing the potential of forest trading tools to deliver additional environmental

  7. A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling

    Science.gov (United States)

    Bai, Zhiyong; Grant, Barth D.

    2015-01-01

    Endosome-to-Golgi transport is required for the function of many key membrane proteins and lipids, including signaling receptors, small-molecule transporters, and adhesion proteins. The retromer complex is well-known for its role in cargo sorting and vesicle budding from early endosomes, in most cases leading to cargo fusion with the trans-Golgi network (TGN). Transport from recycling endosomes to the TGN has also been reported, but much less is understood about the molecules that mediate this transport step. Here we provide evidence that the F-BAR domain proteins TOCA-1 and TOCA-2 (Transducer of Cdc42 dependent actin assembly), the small GTPase CDC-42 (Cell division control protein 42), associated polarity proteins PAR-6 (Partitioning defective 6) and PKC-3/atypical protein kinase C, and the WAVE actin nucleation complex mediate the transport of MIG-14/Wls and TGN-38/TGN38 cargo proteins from the recycling endosome to the TGN in Caenorhabditis elegans. Our results indicate that CDC-42, the TOCA proteins, and the WAVE component WVE-1 are enriched on RME-1–positive recycling endosomes in the intestine, unlike retromer components that act on early endosomes. Furthermore, we find that retrograde cargo TGN-38 is trapped in early endosomes after depletion of SNX-3 (a retromer component) but is mainly trapped in recycling endosomes after depletion of CDC-42, indicating that the CDC-42–associated complex functions after retromer in a distinct organelle. Thus, we identify a group of interacting proteins that mediate retrograde recycling, and link these proteins to a poorly understood trafficking step, recycling endosome-to-Golgi transport. We also provide evidence for the physiological importance of this pathway in WNT signaling. PMID:25775511

  8. Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Alberto Alves da

    2009-07-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  9. Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis

    International Nuclear Information System (INIS)

    Gianoulakis, C.; Seidah, N.G.; Routhier, R.; Chretien, M.

    1980-01-01

    Rats pars intermedia cells were incubated for 3 h with the following amino-acids: a) 35 S-methionine and 3 H-phenylalamine; b) 3 H-valine; and c) 3 H-valine and 3 H-lysine. Radioactive gamma-lipotropin, beta-lipotropin and beta-endorphin were purified on carboxy- methyl-cellulose and characterized by polyacrylamide disc gel electrophoresis af pH 4.5, molecular weight estimation and microsequencing. Rat gamma-lipotropin was shown to differ slightly from ovine gamma-lipotropin in its NH 2 -terminal amino acid sequence, in containing no methionine and having phenylalanine at position 6, valine at positions 13 and 27, and lysine at position 20. The same variations were observed in the sequence of rat beta-lipotropin, while rat beta-endorphin was shown to be identical to the ovine beta-endorphin. Following a 3-h pulse of rat pars distalis, the cells were extracted with care to avoid beta-lipotropin degradation by proteolytic enzymes. A peptide was purified and identified to be rat beta-endorphin, thus demonstrating that beta-endorphin is biosynthesized in pars distalis and is not an extraction artifact. (author)

  10. Eficacia de los antivirales en la parálisis de Bell

    OpenAIRE

    Vázquez, María Cristina; Sánchez, Nury; Calvo, Judith; Perna, Abayubá

    2008-01-01

    Introducción: la parálisis de Bell es una afección frecuente que presenta en 15% de los casos una recuperación incompleta. En los últimos años se ha acumulado evidencia del posible rol del virus herpes simple tipo 1 en su etiología. Objetivos: comparar la eficacia de valaciclovir y prednisona versus prednisona placebo en la parálisis de Bell. Material y método: se realizó un ensayo prospectivo, randomizado y placebo controlado. De los 41 pacientes incluidos, 21 fueron tratados con valaciclovi...

  11. evaluation de la fertilite femelle des arabusta par le niveau de ...

    African Journals Online (AJOL)

    Les hybrides Arabusta sont caractérisés par une faible fertilité exprimée par des taux de caracolis élevés et des taux de loges vides importants induisant des productivités faibles. Pour une stratégie plus efficiente des sélections, il est important de connaître les niveaux de fertilité femelle des différents types de caféiers ...

  12. Densité, morphologie urbaine et qualité de vie. Une approche par le projet

    OpenAIRE

    Occhiuto, Rita; Goossens, Marc; Fisher, Axel

    2013-01-01

    La recherche "Densification des tissus urbanisés en Wallonie: forme, acceptabilité et modalités pour accompagner la mutation des tissus bâtis" s'articule en plusieurs volets thématiques, parmi lesquels figure le volet "formes urbaines, modes d'habitat". Ce dernier volet est abordé selon deux approches parallèles et complémentaires qui se valident mutuellement: la première dite "par le projet" (approche qualitative et opérationnelle) et la seconde par analyse statistique et cartographique (ap...

  13. Situation des personnes transgenres par rapport au VIH/IST en Suisse : rapid assessment

    OpenAIRE

    Bize, R.; Koutaissoff, D.; Dubois-Arber, F.

    2013-01-01

    Ce rapport permet d'identifier le sous-groupe des personnes transgenres pratiquant ou ayant pratiqué le travail du sexe comme une population clairement exposée à un risque notoirement élevé d'infection par le VIH et les IST. L'ampleur rapportée du phénomène justifie pleinement l'inclusion de cette population dans le dispositif de surveillance comportementale du VIH et des autres IST, mais également la réalisation urgente d'actions de prévention communautaire. Par contre, il ne nous permet pas...

  14. Joule Heating of Plasma in the Toroidal Tokamak-3 Device; Chauffage du Plasma par Effet Joule, dans l'Installation Torique; Dzhoulev nagrev plazmy na toroidal'noj ustanovke Tokamak-3; Calentamiento de un Plasma por Efeto Joule en la Instalacion Toroidal Tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Arcimovich, L. A.; Afrosimov, V. V.; Gladkovskij, I. P.; Mirnov, S. V.; Petrov, M. P.; Strelkov, V. S. [Institut Atomnoj Ehnergii, Im. I.V. Kurchatova, Moskva, SSSR (Russian Federation)

    1966-04-15

    function increases during the process and reaches 100 to 200 eV. Spectroscopic measurements of the electron temperature give values close to the computed values. The measured energy distributions of the fast neutral-atom flux fit in well with the assumption that the ion distribution of the plasma resembles a Maxwellian distribution of about 100 eV. A significant departure of this distribution from a Maxwellian is observed in the unstable discharge at the same moments as the characteristic plasma column instabilities. In addition, a perceptible difference is observed in the flux of neutrals from the' ''upper'' and the ''lower'' portions of the column, which can be explained by ion drift fluxes inside the column that have large transverse velocities. (author) [French] Dans l'installation Tokamak-3, on cree un plasma d'hydrogene et on le chauffe par un courant electrique annulaire de 40 a 60 kA. Le temps de passage du courant est de 20 a 30 ms. Une grade partie des experiences a ete faite avec un champ magnetique longitudinal stabilisateur de 25 kOe. La composante transversale du champ magnetique parasite etait compensee au moyen de courants passant dans des spires de correction speciales. Dans ces conditions il ne s'est produit aucun deplacement perceptible du centre de la colonne a partir du plan equatorial du tore, au cours de la decharge, et les auteurs ont observe une derive de la colonne de plasma 'vers l'exterieur' (accroissement du grand rayon de la spire). Ce mouvement peut etre cause par une variation du rayon de la colonne de courant, par le chauffage du plasma ou par l'amortissement des courants de Foucault dans la chemise conductrice. Dans ces conditions, ies auteurs ont reussi a obtenir dans l'installation Tokamak-3 une colonne de plasma, stable du point de vue macroscopique; cependant la temperature du plasma etait inferieure a la temperature prevue en cas d'absence de pertes anormales d'energie. Les processus qui apparaissent dans le cas d'une interaction

  15. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  17. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le