WorldWideScience

Sample records for construisez bien ils

  1. Noam Chomsky, Le bien commun

    OpenAIRE

    Ferrand, Laure

    2014-01-01

    Le bien commun regroupe une série d’entretiens réalisés par le journaliste américain David Barsamian avec Noam Chomsky. Ils traitent essentiellement de l’approche politique et critique de Chomsky à travers les différents écrits qu’il a publiés et les conférences qu’il a données. Ainsi, nous retrouvons dans cet ouvrage les questions principales qui irriguent la pensée de l’auteur : l’économie capitaliste est-elle synonyme de liberté ? Les États-Unis - et plus largement les pays se caractérisan...

  2. Cómo nadar bien

    OpenAIRE

    Navarro Valdivielso, Fernando; Díaz Ureña, Germán; González Vegas, Manuel J.

    2012-01-01

    Nadar bien o nadar mejor es la pretensión final de este libro. Al proceso que se propone para este objetivo lo hemos denominado MÉTODO NB (NADAR BIEN). Nuestro interés se centra en que todos los interesados y practicantes en la natación puedan perfecciona No data (2012)

  3. « Il faut qu’un party se sente bien faible quand il accepte et qu’il recherche de tels appuis ». Femmes, jansénisme et publicité à Paris au xviiie siècle

    Directory of Open Access Journals (Sweden)

    Nicolas Lyon-Caen

    2009-07-01

    Full Text Available Le jansénisme devient, au siècle des Lumières, une déviance publique et donnée à voir à travers les lieux de la Ville. La présence féminine est évidente mais varie selon lessources car l’influence féminine n’est pas simplement tacite, mais constitue bel et bien un droit reconnu et sanctionné par des usages. Les institutions urbaines d’ancien régime sont cependant résolument masculines et l’impuissance des femmes réside plutôt dans leur extériorité au langage de celles-ci, sans que cela les empêche de faire « comme les hommes ». Mais leur investissement effectif dans la cause janséniste pose de manière récurrente, et insoluble, la question de leur rôle politique dans une société de plus en plus travaillée par le problème de la représentation.Contrary to the idea that associates religious deviance or minority with secrecy, Jansenism offers a different case study. During the eighteenth century Jansenists made their deviance public throughout the city of Paris, the major manifestation of which being the pilgrimage to the tomb of Deacon François de Pâris. Even though women participated to the movement, different sources give little evidence, as female influence was not simply tacit, but indeed constituted a right acknowledged by uses. Yet, urban institutions membership was resolutely male, the impotence of women, in that case, can be explained by their being foreign to the discourse of municipal bodies, which did not prevent them from acting “like men”. Therefore, the effective female investment in the Jansenist cause regularly posed the insoluble problem of their political role in a society in which the issue of representation became crucial.

  4. Bien écrire en affaires savoir rédiger pour être lu et convaincre

    CERN Document Server

    Berrou, Jean-Paul

    1991-01-01

    Ce qu'il faut savoir pour bien rédiger ses écrits professionnels au travers d'une démarche méthodique pour bien organiser sa pensée en vue d'écrire efficacement, de conseils et de techniques pour être compris à coup sûr et être lu jusqu'au bout avec intérêt. Agrémenté de nombreux exemples concrets.

  5. Embargo de bienes y sociedad de gananciales

    OpenAIRE

    Gascón Inchausti, Fernando

    2001-01-01

    El trabajo contiene un análisis jurisprudencial de las dificultades dogmáticas y prácticas que genera el embargo de bienes pertenecientes a personas físicas casadas bajo el régimen económico de gananciales. Se distingue en función de si la deuda nació estando vigente la sociedad de gananciales o una vez disuelta, y también, por supuesto, en función del carácter privativo o ganancial del bien y de la deuda en virtud de la cual se ha despachado la ejecución.

  6. Estrategias para aprender a pensar bien

    OpenAIRE

    Monereo i Font, Carles,

    1995-01-01

    El autor explica con cierto detalle qué significa aprender a pensar bien y cómo hacer un uso apropiado del conocimiento que los alumnos poseen. En este sentido, expone algunas premisas, estrategias y procedimientos que contribuyen a ello.

  7. Equilibrio en el mercado de bienes

    OpenAIRE

    León Rodríguez, Mª Dolores; Fernández Pérez, Ana Mª

    2008-01-01

    Obtención del equilibrio en el mercado de bienes, efectos del establecimiento de un impuesto por unidad de producto sobre el equilibrio del mercado. Establecimientos de precios máximos y mínimo. Excedente del consumidor y del productor

  8. DERECHO INTERNACIONAL PRIVADO Y CONVENIO UNIDROIT DE 24 DE JUNIO DE 1995 SOBRE BIENES CULTURALES ROBADOS O EXPORTADOS ILEGALMENTE

    OpenAIRE

    Calvo Caravaca, Alfonso Luis; Universidad Carlos III de Madrid.

    2004-01-01

    El presente estudio analiza el convenio sobre los bienes culturales ro- bados o exportados ilícitamente, hecho en Roma el 24 de junio de 1995 y elaborado por UNIDROIT. Dicho convenio traza un sistema jurídi- co para lograr la restitución de tales bienes por iniciativa de las partes interesadas o de los estados, según los casos, construyendo una nueva “cultura legal” sobre el tratamiento jurídico de los bienes culturales en los circuitos internacionales del artículo El alcance-espacial del con...

  9. El arte de vivir bien y dignamente

    Directory of Open Access Journals (Sweden)

    Aguinaga Benítez Oscar William

    1997-11-01

    Full Text Available

    Por tradición y a diferencia de otras culturas, nos han enseñado en la casa, escuela o colegio y mucho más en el trabajo a buscar amor, prosperidad, salud, felicidad y satisfacción en el exterior y jamás se nos ha hecho ver, ni se nos ha inculcado que la mayor riqueza está en el interior de cada uno de nosotros. Bien dice el doctor Dyer "se nos ha condicionado para creer que recibimos la gracia de la vida" y no para que disfrutemos de la inmortalidad de nuestro yo espiritual, se niega la opción de estar siempre acompañado de una energía que para muchos es lo divino y para otros es la conciencia.

  10. Santé et biens communs : un regard de juriste.

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    Isabelle Moine-Dupuis

    2010-11-01

    Full Text Available La santé constitue un domaine dans lequel les notions de bien commun ou de bien public mondial sont particulièrement pertinentes. Il faut cependant préciser de quels biens il est question. A titre d’exemple, le droit français comporte des notions susceptibles de qualifier le droit aux soins (comme droit inaliénable, ou le médicament, objet de propriété intellectuelle comme de propriété « traditionnelle ». Un droit international des biens de santé peut de la même manière être fondé sur un droit d’usage de chacun sur la molécule qui est la même dans le médicament générique et celui de marque. Une procédure d’accès équivalent aux produits, brevetés ou non, pourrait être mise en œuvre par principe dès la découverte, afin de parvenir rapidement à des prix équitables.Health is a field particularly suitable for notions as commons or public goods. It is necessary however to know which goods may be concerned. For instance, French lawyers use concepts which can be used in order to qualify right to care (as an inalienable right, or medicine as an object of intellectual property as well as “traditional” one. An international law for health goods could be also based on a right of use for each person on the molecule which is the same in the generic drug or in the patented one. A process of “equivalent access” to licensed or free products could be initiated, from the discovery itself to the use, in order to obtain rapidly fair prices.

  11. Modelización de los Bienes Públicos

    Directory of Open Access Journals (Sweden)

    Juan Carlos Aguado Franco

    2014-02-01

    Full Text Available En el contexto de los bienes públicos es bien conocida la posibilidad de que surja una ineficiencia económica debida a que los individuos puedan verse tentados a actuar como “free-riders”, mostrando una nula disposición a pagar, con la esperanza de que, si ese bien o servicio termina siendo suministrado a un individuo que lo pague, los demás van a poder disfrutarlo igualmente sin incurrir en ningún coste. Si todo el mundo obrase de esa manera, sin embargo, el bien público finalmente no sería suministrado para nadie, disminuyendo el bienestar de los interesados, salvo que el Estado decidiera hacerse cargo de su provisión. Aunque la comprensión de este planteamiento es inmediata, la plasmación en un modelo de esta realidad, sin embargo, no es tan sencilla. Así, dependerá de los supuestos adicionales que realicemos, tanto de la función de producción del bien público (véase al respecto por ejemplo, Sandler, 1992; Marwell y Oliver, 1993; Heckathorn, 1996 o Kollock, 1998 como de la interrelación existente entre los individuos interesados, lo que nos llevará a la consideración de distintos dilemas, como, entre otros, el del voluntario o el del altruista (Diekman, 1985; Rapoport, 1988; Heckathorn, 1991; Weesie, 1993; Goetze, 1994; Weesie, 1994. En este trabajo se examina la conveniencia de la aplicación de unos u otros modelos en función de las circunstancias presentes en cada caso particular. Palabras clave: bienes públicos, dilemas sociales.

  12. Propriété, biens publics mondiaux, bien(s commun(s : Une lecture des concepts économiques

    Directory of Open Access Journals (Sweden)

    Jérôme Ballet

    2008-03-01

    Full Text Available La notion de bien public mondial s’est développée ces dernières années. Elle renvoie à un dépassement ambigu de la notion usuelle dans la théorie économique de bien public. A cette occasion elle ouvre le débat sur l’équité en complément de l’efficience. De ce fait, la confrontation de cette nouvelle notion avec l’analyse de l’efficience des régimes de propriété s’impose. Par ailleurs, la confrontation avec la notion de bien commun, notion elle aussi en développement, éclaire l’enjeu autour de l’équité.Property, Global Public Goods, Common Good(s : A Lecture. The concept of global public good emerged these last years. It proposes, in an ambiguous way, to go beyond the usual concept of public good. Then, added to usual questions on efficiency, the debate on fairness becomes a stake. Confrontation with analysis on property rights command attention, Furthermore, confrontation with the concept of common good, also a developing concept, highlight stake around fairness.

  13. Bien faire un cours, un exposé, une conférence

    CERN Document Server

    Brown, George

    1981-01-01

    Le livre de Georges Brown est un livre important pour deux raisons : - Parce qu'il propose à tous les formateurs et enseignants une approche méthodologique de la transmission orale des connaissances. En effet, il ne suffit pas de bien connaître son sujet pour le faire comprendre à son auditoire. Ce livre est conçu pour mener le lecteur pas à pas dans la découverte de son propre style d'explication, de ses points faibles et de ses points forts. - Parce qu'il permet au lecteur, grâce à la pratique des 45 exercices contenus dans l'ouvrage, de faire alterner la réflexion et la performance individuelle avec l'échange d'expériences et l'auto-évaluation des méthodes d'enseignement oral. Ce livre, qui possède toutes les qualités du pragmatisme anglo-saxon, met au service de la formation un outil essentiellement pratique. Il s'adresse donc à tous ceux qui donnent des cours, font des séminaires,ou ont à exposer leurs idées devant un auditoire. EXPLIQUER, C'EST D'ABORD SAVOIR COMMUNIQUER.

  14. CONTROL DE INVENTARIO DE BIENES MUEBLES EN LA GERENCIA REGIONAL DE SALUD, AREQUIPA, 2010

    OpenAIRE

    REVILLA VELA, DELFINA LUISA

    2014-01-01

    VERIFICACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA TASACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA CODIFICACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DEL ETIQUETADO EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA REGULARIZACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA CONCILIACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES APRECIACIÓN GLOBAL SOBRE EL CONTROL DE INVENTARIO DE BIENES MUEBLE...

  15. CONTROL DE INVENTARIO DE BIENES MUEBLES EN LA GERENCIA REGIONAL DE SALUD, AREQUIPA, 2010

    OpenAIRE

    REVILLA VELA, DELFINA LUISA

    2014-01-01

    VERIFICACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA TASACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA CODIFICACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DEL ETIQUETADO EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA REGULARIZACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES VERIFICACIÓN DE LA CONCILIACIÓN EN EL CONTROL DE INVENTARIOS BIENES MUEBLES APRECIACIÓN GLOBAL SOBRE EL CONTROL DE INVENTARIO DE BIENES MUEBLE...

  16. Vite et bien 1 A1/A2 : méthode rapide pour adultes

    CERN Document Server

    Miquel, Claire

    2009-01-01

    Vite et bien s'adresse à des adultes pressés et impatients de communiquer avec succès en français ! Le vocabulaire est simple et usuel et les thèmes, variés, pour faire face, efficacement, à toutes les situations de la vie quotidienne et professionnelle. Livre + CD audio et corrigés inclus. La méthode rapide Vite et bien 1 permet à la fois d'apprendre le français et de découvrir la réalité de la vie en France, les différences culturelles, le langage de la vie quotidienne, le tout en un temps record. En effet, le premier volume couvre, en vingt unités, les niveaux A1 et A2 du Cadre Européen de référence (CECR). Ainsi, en 100 à 120 heures de cours selon les publics, il sera possible d'acquérir une bonne base de grammaire et de vocabulaire, claire, simple, fonctionnelle, et de se sentir à l'aise dans la communication orale et écrite. L'ouvrage s'adresse aux vrais et et aux faux débutants, constituant donc un outil d'apprentissage et/ou de rafraîchissement des connaissances. Chacune des v...

  17. Industrias de bienes de consumo buscan el éxito

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    José Ernesto Ramírez

    1987-04-01

    Full Text Available Requerimientos críticos para el éxito competitivo de las empresas, cuando se desarrolla su sistema de negocios: El caso de industrias seleccionadas de bienes de consumo en Colombia. Joseph Ganitsky Brandwayn. (Tesis de doctorado, Harvard University, School of Business Administration, 1974 University Microfilm International. Ann Arbor (Michigan. 1983, 317 páginas; 28 cuadros, 4 apéndices. (Disponible en la Biblioteca Luis Angel Arango.

  18. Vivir bien, entre utopía y realidad

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    Kepa Artaraz

    2013-01-01

    Full Text Available Los paradigmas dominantes del bienestar siguen empeñándose en entender lo que este término significa. De igual manera, los diseñadores de políticas públicas ( policy makers se empeñan en hacer realidad las visiones dominantes de bienestar. este artículo examina la noción del bienestar adoptada recientemente por la constitución boliviana. se da gran relevancia a las nociones indígenas de «vivir bien», concepto que podría traducirse como «vivir bien en grupo» bajo los principios de sociabilidad y la promoción de valores de reciprocidad. adoptado por los bolivianos en su Constitución de 2009 como uno de los valores fundamentales, el artículo explora la contribución que puede hacer a las nociones de bienestar. sostiene que «vivir bien» constituye progreso en nuestras nociones de bienestar por el énfasis que hace el concepto en las relaciones armónicas, no solo en la sociedad, sino también con la naturaleza (la pachamama —nuestra Madre tierra—, brindando un nexo con la sostenibilidad que las actuales concepciones de bienestar a menudo no logran.

  19. Le bien commun : une intention éthique entre la loi du marché et l’individualisme

    OpenAIRE

    Beauchemin, Jacques

    2016-01-01

    Considérer le bien commun du point de vue des objets qu’il recouvre conduit à considérer un ensemble de « biens sociaux » associés à la nature biologique, sociale et politique des individus en société. Or la définition du bien commun ne réside pas seulement dans les objets auxquels on peut l’associer mais surtout dans la capacité collective à faire de la société un projet éthique de vivre ensemble. Ainsi, l’atomisation de la société que provoquent la marchandisation et l’individualisme contre...

  20. "Bien Común" base del desarrollo de las organizaciones

    OpenAIRE

    2007-01-01

    Texto correspondiente a la Clausura del Curso de Desarrollo Directivo de la Universidad de Alcalá El papel de la Universidad es orientarse al desarrollo de la persona y de su futuro. Y ello tiene lugar dentro de comunidades, corporaciones, empresas en las que su éxito depende de la capacidad individual y social de la creación de ¿bien común¿, que permite generar las bases para compartir. Sólo cuando hay una base compartida, este es el intangible por excelencia, pueden con...

  1. Il laser

    CERN Document Server

    Smith, William V

    1974-01-01

    Verso il 1960, il laser era ancora "una soluzione alla ricerca di un problema", ma fin dagli anni immediatamente successivi si è rivelato uno strumento insostituibile per le applicazioni più svariate.

  2. Bien común y ética pública: Alcances y límites del concepto tradicional de bien común

    National Research Council Canada - National Science Library

    Dorando J. Michelini

    2007-01-01

    Con el concepto de bien común se ha hecho referencia, a través de la historia, a aquellos bienes materiales e inmateriales que no se circunscriben a una persona sino que remiten a todos y cada uno de los miembros de la sociedad...

  3. Bienes primarios, igualdad de oportunidades e igualdad de recursos

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    Guibet-Lafaye, Caroline

    2005-12-01

    Full Text Available The liberal equalitarian theories of justice give to the equal concern a central importance. When they consider which good should be primarily allocated, they are confronted with a plurality of objects. The implications and aims of these theories depend on their definition of the nature of the resource they privilege. This will be demonstrated by an analysis of the Rawlsian theory of primary goods, of the equality of resources theory and of the equality of opportunities theory. This analysis shows that it is not possible, as the equality of resources approach thought, to give up the dimension of welfare in the evaluation of individual situations. Equity does not only consist in equalizing the initial resources distribution but also consist in considering the final distribution of individual results -and therefore the distribution of welfare- the agents end up with.

    Las teorías liberales igualitarias de la justicia, las cuales otorgan a la igual solicitud una importancia crucial, afrontan un buen número de cuestiones cuando consideran qué bienes deberían ser distribuidos prioritariamente. Las implicaciones y perspectivas de estas teorías dependen de su definición del tipo de recurso que privilegien, tal y como veremos mediante un análisis de la teoría rawlsiana de los bienes primarios, de la teoría de la igualdad de recursos y de la teoría de la igualdad de oportunidades. Este análisis mostrará que no es posible descartar la dimensión del bienestar en la evaluación de las situaciones individuales, tal y como han pensado las concepciones igualitarias de los recursos. La igualdad no consiste sólo en igualar los recursos iniciales, sino también en considerar la distribución final de los resultados individuales -y, en consecuencia, del bienestar- alcanzados por los agentes.

  4. La desprotección de bienes culturales: Enajenación de bienes públicos; la descatalogación

    OpenAIRE

    Bermúdez Sánchez, Javier

    2015-01-01

    En principio la enajenación de bienes culturales de las Administraciones públicas está expresamente prohibida. Sin embargo, se ha planteado la posibilidad de descatalogar los bienes para proceder a continuación a su enajenación. La jurisprudencia es muy restrictiva al respecto, dado que califica como actuación reglada de la Administración el dejar sin efectos la catalogación de los bienes culturales, como asimismo la catalogación. A partir de la regulación y jurisprudencia solo...

  5. Los bienes comunes intangibles en el capitalismo cognitivo.

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    Álvaro Ramis Olivos

    2014-10-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 Este texto analizará críticamente la actual fase económica para mostrar la importancia de los bienes comunes intangibles. Sondea la tesis de un nuevo modo de producción «en ciernes», basado en la gestión colaborativa. Analiza los intangibles de acuerdo a su calidad y carácter. Compara los sistemas de patentes y derechos de propiedad intelectual que permiten su apropiación y las resistencias a su «comoditización» desde el software libre y las propuestas de flexibilización de derechos de autor. Advierte sobre el «fetichismo tecnológico» y propone un marco mínimo de discernimiento en dilemas vinculados a estas materias. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}

  6. Quand les anges deviennent de bien mauvais messagers

    OpenAIRE

    Latour, Bruno

    2007-01-01

    Ainsi, il y aurait des croyances des énoncés seraient échangés entre les hommes à propos d'objets - licornes, Saintes Vierges, ovnis - qui n'auraient pas de réalité ou dont les référentiels seraient incapables de présenter une valeur de vérité. D'où un grave problème : comment expliquer que nous échangions tellement de propos qui affectent de porter sur quelque chose d'objectif alors qu'ils n'informent réellement que sur l'état des sujets qui les tiennent ? Pour les philosophes du langage, le...

  7. Ciberciudadanía, cultura y bienes públicos

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    Álvarez, J. Francisco

    2009-06-01

    Full Text Available Net society is provoking dramatic changes in several aspects of our daily life as cultural traits, business and the more disparages spheres of privacy and social life. We must attend both to freedom of access and to new services generation because of the peculiar form public goods are raising in the Net. To supersede individual capability limitations and to diffuse digital and cultural gaps, electronic government could be a cultural decisive tool in this phase of cibersociety enhancement. Technologies enhanced the human capabilities, as well as with the social actions and its framework, including cultural production and management. Technologies are also transforming the generation, reproduction and transmission of (social knowledge.La sociedad red transforma la vida cotidiana, las diversas manifestaciones culturales, los negocios, las esferas más diversas de la vida privada y social. La forma en que se generan los bienes públicos en la red exige una preocupación explícita por la libertad de acceso y la generación de nuevos servicios, que ayuden a superar limitaciones de los individuos y faciliten desdibujar las diversas brechas digitales y ciberculturales. El gobierno electrónico resulta culturalmente decisivo en esta fase de expansión de la cibersociedad. Las tecnologías amplían las capacidades humanas, expanden el espacio y las formas de acción social, incluidas la producción y gestión cultural. También producen cambios en las formas de generación, reproducción y transmisión del conocimiento (social.

  8. Pluralismo y bien común en el derecho constitucional

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    Pablo Nuevo

    2004-01-01

    Full Text Available En el presente artículo, el profesor Pablo Nuevo analiza las consecuencias que el abandono de la doctrina del bien común tiene en el derecho constitucional, a partir del estudio de la incoporación de valores al ordenamiento jurídico que realiza la Constitución Española de 1978. Esta incorporación parecería dotar de contenido material a la Constitución, que pasa a estar al servicio de la dignidad de la persona y de los valores de justicia, libertad, igualdad y pluralismo político. No obstante esta positivación de un orden axiológico, a juicio de Nuevo, el entendiminiento que el Tribunal Constitucional ha realizado del valor pluralismo contribuye a debilitar el propio Estado constitucional pues el Tribunal, de la mano del principio democrático y de la soberanía popular, ha interpretado el valor pluralismo como relativismo, negando a los valores un fundamento más allá del consenso. Entender el pluralismo como igual legitimidad de toda representación del hombre y del mundo, que funda un derecho a seguir dicha concepción en todos los aspectos de la vida social, favorece que los postulados de la Constitución sean entendidos como significantes sin significado, debiendo éste ser construido a partir del principio mayoritario, lo que conduce tanto al debilitamiento de los derechos fundamentales, como a la progresiva erosión de las condiciones sociales en que puede favorecer el Estado constitucional. Como subraya el autor, el Estado moderno vive de presupuestos que no puede crear, pero sí en todo caso destruir. De igual manera, para el profesor el constitucionalismo liberal, pluralista e individualista de nuestros tiempos, carece de herramientas conceptuales para solucionar las aporías que plantea las sociedades occidentales de nuestro tiempo, que se debaten entre el miedo al Leviatán y la inseguridad de un mundo anómico. El autor sostiene que solo con una vuelta a la ley natural es posible ordenar la vida política de manera que

  9. Economía institucional de un bien mayor

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    Óscar A. Alfonso Roa

    2007-12-01

    Full Text Available La provisión de los servicios de acueducto y alcantarillado en Colombia ha sido sometida, desde 1994, a una terapia consistente en la promoción de un modelo empresarial que se abre paso a costa de la estigmatización del municipio como mal prestador y como asignador ineficiente de unos recursos escasos. a quince años de operación del modelo empresarial y en desarrollo del Acto Legislativo 04 de 2007, el Gobierno nacional ha introducido otra reforma, en esta oportunidad al Sistema General de Participaciones, esgrimiendo en la exposición de motivos los mismos argumentos de antaño, cuando en verdad mediante la prestación directa de los municipios sólo se provee de estos servicios a una porción minoritaria de la población urbana del país. En la primera parte se discute la noción del agua potable como bien mayor y en la segunda se presenta una breve síntesis de la evolución institucional de la provisión del agua potable en colombia. en la tercera parte se discuten algunos rasgos centrales del proceso de urbanización de la población colombiana a la que se sirve con el servicio de acueducto mientras que en la última se analiza la coyuntura reciente con énfasis en la crítica a la reforma introducida por el acto Legislativo 04 de 2007. este artículo propone otros puntos de vista para criticar, además de la reforma en curso, las fallas de un esquema de provisión cifrado en un enfoque empresarial sometido a una inocua regulación, que no logra conciliar los intereses de ampliación de las ganancias de las empresas de servicios públicos con las aspiraciones sociales en materia de universalización y calidad de los servicios de acueducto y alcantarillado.

  10. Les Nations unies et les biens publics mondiaux : contributions historiques et défis à venir

    Directory of Open Access Journals (Sweden)

    Bruce Jenks

    2012-04-01

    Full Text Available Cet article explore la thèse selon laquelle la contribution la plus importante de l’Organisation des Nations unies (ONU à la production de biens publics mondiaux a été son rôle dans l’instauration d’espaces et de capacités permettant de créer des valeurs communes. Débutant par la Charte elle-même, l’auteur retrace l’évolution de cette contribution à travers différentes phases historiques. Il analyse l’impact de la mondialisation sur le rôle des Nations unies ; il identifie notamment la qualité de la perméabilité en tant que produit de la mondialisation, ce qui est essentiel à la compréhension des défis actuels auxquels font face les Nations unies et également au cœur du programme sur les biens publics mondiaux (BPM. L’article examine brièvement, sous cet angle, l’évolution du rôle des Nations unies dans les domaines de la paix et de la sécurité, des droits de l’homme et de la coopération au développement. En conclusion sont identifiés huit leviers de changement qui détermineront la faculté des Nations unies à contribuer de manière substantielle aux BPM : l’instauration de normes et de valeurs communes, la qualité de la direction, l’amélioration de la gouvernance, un réalignement institutionnel, des financements innovants, le renforcement de la consolidation des instruments juridiques, la concentration sur des points stratégiques et le pouvoir des réseaux.

  11. Bien común y ética pública: Alcances y límites del concepto tradicional de bien común

    Directory of Open Access Journals (Sweden)

    Dorando J. Michelini

    2007-12-01

    Full Text Available Con el concepto de bien común se ha hecho referencia, a través de la historia, a aquellos bienes materiales e inmateriales que no se circunscriben a una persona sino que remiten a todos y cada uno de los miembros de la sociedad. Entre esos bienes suelen contarse elementos básicos para la supervivencia humana biológica, como el aire y el agua, pero también el derecho a participar en el usufructo de los bienes de la cultura. En algunos casos, el bien común es equiparado al bienestar general; en otros, a la suma de intereses particulares o al beneficio de la mayoría, como cuando se busca el mayor bien para el mayor número posible de individuos. Más allá de las diversas interpretaciones, la promoción del bien común sigue siendo en la actualidad un objetivo clave del Estado en el ideario democrático y un tema recurrente de la ética pública. En lo que sigue, se reconstruye críticamente el concepto tradicional de bien común, haciendo especial referencia a las obras de Platón, Aristóteles y Santo Tomas, con el fin de sentar bases para una nueva comprensión de la idea de bien común en sociedades pluralistas y democráticas.With the concept of commom good reference has been made, along history, to those material and immaterial goods which are not circumscribed to a person, but remit to each and every member of society. Among those goods, basic elements for biological human survival, such as air and water, are usually included, but also the right to participate of the profits of cultural goods. In some cases, commom good has been made equivalent to common wellfare; in others, to the summation of particular interests or to the benefit of the majority. Beyond the diverse interpretations, the promotion of common good continues at present to be a key aim of State in the democratic ideary and a recurrent issue in public ethics. In what follows, the concept of traditional common good has been reconstructed, making special reference to the

  12. Il dolore

    Directory of Open Access Journals (Sweden)

    Prof. Giorgio Cruccu

    2011-09-01

    Full Text Available Il dolore è l’aspetto negativo di un sistema sensitivo indispensabile alla vita, detto sistema nocicettivo, dal latino noxa e nocēre. I bambini con difetti congeniti della trasmissione o dell’elaborazione percettiva dei segnali dolorifici (analgesia congenita vanno incontro ad una serie di lesioni di cui non si accorgono, sempre più gravi. Crescendo, possono riconoscere il pericolo attraverso l’educazione e l’esperienza, ma, senza l’allarme dato dal dolore, molte malattie possono evolvere senza che siano combattute per tempo, in una spirale che spesso conduce al decesso.

  13. "Vivir Bien" y pobreza multidimensional. ¿Es posible una conciliación conceptual?

    OpenAIRE

    Ahmed Eid; Javier Aliaga Lordemann

    2013-01-01

    Este documento explica cómo el concepto de Vivir Bien constituye un paradigma prevalente, no estructurado en todos los niveles paradigmáticos, lo que hace que no pueda considerarse como un paradigma de desarrollo sincrético y global. Además, los autores encuentran que si bien existe un vínculo entre el enfoque de capacidades y el concepto de Vivir Bien, una medición de éste, via un indicador de pobreza multidimensional, no es posible, dadas las complejidades intrínsecas en la postulación de u...

  14. El bien vivir: ¿cuidado de la salud o proyecto vital? Segunda parte

    Directory of Open Access Journals (Sweden)

    Leonardo Viniegra Velázquez

    2016-07-01

    Se arguye acerca de la superioridad de proyectos vitales altruistas en la consecución del bien vivir comunitario, sobre los afanes centrados en la preservación y el cuidado de la salud que favorecen el individualismo, la pasividad y el statu quo. La búsqueda del “bien morir” es el mejor ejemplo de la influencia benéfica de este tipo de proyectos en el cuidado de la salud.

  15. Il Gioco

    Directory of Open Access Journals (Sweden)

    David Beronio

    2016-02-01

    Full Text Available Chi si occupa di teatro incontra il gioco innanzitutto come una categoria estetica insita nei processi che caratterizzano l’atto teatrale. Ma dall’approfondimento di tali meccanismi emerge anche la potenzialità conoscitiva del gioco, come condizione umana di profonda consapevolezza di sé. Attraverso un percorso che passa attraverso Breton, Platone, Huizinga, e Alessandro Fersen, viene qui proposta una lettura del gioco come carattere fondamentale dell’arte e della conoscenza.

  16. TRASMISIÓN DE BIENES Y REGISTRO DE LA PROPIEDAD EN ESPAÑA (SEGUNDA PARTE

    Directory of Open Access Journals (Sweden)

    Joaquín Sánchez Cebrián

    2009-01-01

    Full Text Available La circulación de los bienes en el tráfico jurídico por la voluntad de los particulares es un tema crucial que interesa, no sólo a las partes del contrato, sino, a todos en general, y, en particular, a los acreedores del transmitente o del adquirente y a los terceros adquirentes de derechos sobre el bien. En este trabajo se analizará el régimen de trasmisión de los bienes por negocio inter vivos en el Derecho español, dentro del marco europeo, y con particular referencia a la trasmisión inmobiliaria. España adopta un peculiar sistema de trasmisión de los bienes porque se establecen reglas genéricas cuya aplicación se da con independencia de la naturaleza mueble o inmueble del bien; pero a su lado se superponen otras que tratan de fijar los efectos de la publicidad registral inmobiliaria. La coordinación entre dichas reglas produce un original resultado, que puede constituir el punto de encuentro de los diversos sistemas registrales europeos.

  17. Bienes públicos y cooperación regional para el desarrollo : Una nueva mirada

    OpenAIRE

    Sandler, Todd

    2013-01-01

    En el presente artículo se ofrece un nuevo enfoque sobre los bienes públicos y el papel que desempeñan en la promoción del desarrollo sustentable y la cooperación en el ámbito de América Latina. En primer lugar, se describen las características esenciales de los bienes públicos (no rivalidad y no exclusión de beneficios, y tecnología de agregación de la oferta pública) y su influencia en la prognosis de la provisión de bienes públicos regionales. Desde el punto de vista de la acción colectiva...

  18. FacturaBien : Sistema de gestión de facturación y contabilidad

    OpenAIRE

    García Núñez, Marcos

    2015-01-01

    El presente documento describe en detalle el proyecto de desarrollo de una aplicación web de gestión, llamada 'FacturaBien'. Esta aplicación permite realizar todas las tareas asociadas a la gestión administrativa de la actividad empresarial de una manera eficiente y cómoda, automatizando un gran número de tareas. Aquest document descriu en detall el projecte de desenvolupament d'una aplicació web de gestió, anomenada 'FacturaBien'. Aquesta aplicació permet realitzar totes les tasques assoc...

  19. La preservación de bienes culturales en el Colegio Nacional de Buenos Aires (UBA)

    OpenAIRE

    De Grazia, Amalia; Guidobono, Eugenia; Mayoni, María Gabriela; Wortley, Ana

    2010-01-01

    A partir del año 2007 se dio lugar en el Colegio Nacional de Buenos Aires, proyectos de Revalorización de Bienes Culturales enfocados en la recuperación de material didáctico. La misión de un Plan Integral de Preservación incluye los trabajos de documentación, conservación preventiva y restauración de los bienes culturales, así como la difusión de criterios utilizados y toda aquella información necesaria para el entendimiento de los procesos realizados. Uno de los objetivos fundamentales fue ...

  20. Polarización en el consumo de (ciertos) bienes de lujo

    OpenAIRE

    Pablo D. López Zadicoff

    2009-01-01

    El trabajo explora la posibilidad teórica de que la demanda de ciertos bienes presente una curva de Engel en forma de S. Se desarrolla un modelo donde la utilidad depende de dos funcionalidades, así como del nivel de estatus. Se plantea que existen tres bienes, uno de los cuales posee aplicación dual en términos de estatus y funcionalidad. Asimismo los agentes poseen un consumo autónomo de estatus el cuál es función de su dotación de riqueza. Bajo el modelo planteado, se exploran las condicio...

  1. FacturaBien : Sistema de gestión de facturación y contabilidad

    OpenAIRE

    García Núñez, Marcos

    2015-01-01

    El presente documento describe en detalle el proyecto de desarrollo de una aplicación web de gestión, llamada 'FacturaBien'. Esta aplicación permite realizar todas las tareas asociadas a la gestión administrativa de la actividad empresarial de una manera eficiente y cómoda, automatizando un gran número de tareas. Aquest document descriu en detall el projecte de desenvolupament d'una aplicació web de gestió, anomenada 'FacturaBien'. Aquesta aplicació permet realitzar totes les tasques assoc...

  2. Créations graphiques réussissez vos brochures, logos, pages web, newsletters, flyers, et bien plus encore !

    CERN Document Server

    McWade, John

    2010-01-01

    Dans cet ouvrage, qui regroupe un florilège des meilleurs projets professionnels publiés dans son célèbre magazine de graphisme, Before & After, John McWade offre une présentation approfondie des principes de base du graphisme, avant de partager concrètement techniques et procédés. Dans un style simple et convivial, il analyse différentes créations graphiques abouties – brochures, lettres d'information, sites web, cartes de visite et autres supports visuels – et explique le pourquoi et le comment de leur réussite. À votre tour, inspirez-vous de ces exemples et employez ces mêmes techniques à l'envie pour améliorer vos propres documents. Vous apprendrez à: rogner des photos pour parfaire leur fonction et leur signification; attirer le regard du lecteur à l'emplacement souhaité à l'aide de huit solutions différentes; travailler sur les composants de base de la création graphique, tels que le trait, la forme, la direction, le mouvement, la mise à l'échelle, la couleur, et bien d'a...

  3. bien reconocida

    Directory of Open Access Journals (Sweden)

    N. Prat

    2015-01-01

    Full Text Available En el año 2014 se conmemora el décimo aniversario de la muerte del Profesor Ramón Margalef. En este artículo se hace un repaso a las publicaciones realizadas por el Dr. Margalef, que llegan a un total de 563 trabajos. La temática dominante de los mismos es la ecología acuática, tanto marina como de agua dulce, y mayormente centrados en los estudios de plancton. Sus trabajos están sobre todo publicados en castellano, en catalán y, en menor medida en inglés, en casi 100 revistas diferentes de todo tipo (desde revistas divulgativas a científicas. Destacan por número los artículos publicados en las revistas “Investigación Pesquera” y “Publicaciones del Instituto de Biología Aplicada”, aunque numéricamente los capítulos de libros y las actas de congresos dominan sus trabajos. De todos estos trabajos, 383 se encuentran citados en la “Web of Science” con un promedio cercano a las 100 citas por año, destacando su trabajo de 1978 sobre las formas de vida del fitoplancton, que sigue siendo muy citado (más de 50 citas por año y con tendencia incluso a crecer en el tiempo. Es destacable el poco conocimiento que se tiene de sus libros (con excepción del primero que publicó en inglés titulado “Perspectives in Ecological Theory”, de 1968. A pesar del gran reconocimiento internacional que tuvo Margalef en vida, hoy en día parece que su obra es en gran parte desconocida por los ecólogos del siglo XXI. Su nombre ha desaparecido de los libros de texto de ecología y una de sus grandes aportaciones a la ecología moderna (introducir la teoría de la información en Ecología y el índice de Shannon-Weaver como medida de diversidad no aparece en los manuales de ecología.

  4. Mental Health and Well-Being across the Military Spectrum (Bien-etre et sante mentale dans le milieu militaire)

    Science.gov (United States)

    2011-04-01

    Apr 2011 Mental Health and Well-Being across the Military Spectrum ( Bien -être et santé mentale dans le milieu militaire) Research and Technology...Spectrum ( Bien -être et santé mentale dans le milieu militaire) Papers presented at the RTO Human Factors and Medicine Panel (HFM) Symposium held in...research be conducted to demonstrate the usability of these technologies in real world settings. ES - 2 RTO-MP-HFM-205 Bien -être et santé

  5. El reconocimiento de las personas con discapacidad. Posibilidad de acceso a los bienes culturales

    OpenAIRE

    Argento Nasser, Ana

    2010-01-01

    Este es un trabajo empírico-conceptual que procura analizar cómo es el real reconocimiento que tienen las personas con discapacidad a institucional. El presente artículo se centra, para delimitar el campo, en el reconocimiento que tienen a nivel cultural, específicamente en el acceso a los bienes culturales.

  6. VALORACIÓN ECONÓMICA DE BIENES AMBIENTALES POR BENEFICIARIOS CIRCUNDANTES Y NO CIRCUNDANTES

    Directory of Open Access Journals (Sweden)

    Mauricio G Villena

    2013-06-01

    Full Text Available La pregunta básica de investigación detrás de este trabajo es cómo difiere la valoración económica de un bien ambiental considerando beneficiarios circundantes (quienes viven cerca del bien en cuestión y no circundantes (quienes habitando el país donde se encuentra el bien, viven en poblaciones distantes y por tanto disfrutan esporádicamente de los beneficios provistos por el bien ambiental. En particular, en este documento se valora económicamente el Bosque de Algarrobos de la comunidad de Tiataco (Bolivia, realizando un análisis comparativo entre beneficiarios circundantes (familias residentes en la comunidad de Tiataco y beneficiarios no circundantes (familias residentes en la ciudad de Cochabamba, a 35 Km de Tiataco, a través del Método de Valoración Contingente con formato binario. Se estimaron medidas de cambio en el bienestar para ambos grupos, empleando estimaciones paramétricas y no paramétricas. Posteriormente, estas medidas se compararon estadísticamente por medio de la construcción de intervalos de confianza (entre estimaciones paramétricas y no paramétricas de cada población y entre ambas poblaciones. Por último, se identificaron los componentes del valor económico total que los beneficiarios tanto circundantes como no circundantes asignaron al bosque.

  7. Arrendamiento de bienes inmuebles, su tratamiento en el impuesto al valor agregado

    OpenAIRE

    Guarda, Pablo Alberto

    2012-01-01

    El presente trabajo intenta destacar el tratamiento brindado por el Impuesto al Valor Agregado (IVA) al arrendamiento o locación de bienes inmuebles, mostrando en detalle, las distintas modalidades llevadas a cabo en la práctica por locadores y locatarios. Fil: Guarda, Pablo Alberto. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.

  8. El sumo bien kantiano: el objeto construído de la ley moral

    Directory of Open Access Journals (Sweden)

    Alonso Villarán

    2016-01-01

    Full Text Available El presente artículo tiene tres objetivos: a. compilar las críticas planteadas en contra del sumo bien kantiano (un mundo donde la virtud es premiada con felicidad; b. elaborar una revisión crítica de las respectivas defensas; y c. desarrollar una nueva defensa, con énfasis en el problema de derivación (según el cual el sumo bien no se deriva de la ley moral. Respecto al primero punto, el artículo muestra que son al menos cinco los problemas que amenazan la doctrina: heteronomía, derivación, imposibilidad, irrelevancia y dualismo. Respecto al segundo, el artículo revela que las múltiples defensas elaboradas en nombre del sumo bien son fuente, a su vez, de otros problemas, como los de incompletitud, ilusión, injusticia, deslealtad y escisión. Respecto al tercer y principal punto, y empezando por la derivación, el artículo propone ver al sumo bien como el objeto construido de la ley moral. Resuelto el problema de derivación, el artículo ofrece breves respuestas a los otros problemas en juego. El artículo también traduce por primera vez, del inglés al español, fragmentos de importantes publicaciones sobre el sumo bien.

  9. Il mondo dentro il mondo

    CERN Document Server

    Barrow, John D

    1991-01-01

    Davvero esistono “lì fuori” leggi di natura, che stanno in attesa di essere scoperte, indipendenti dal nostro modo di pensare, o esse rappresentano soltanto la descrizione più conveniente di ciò che abbiamo visto? Come è nata l’idea stessa di “leggi di natura”? Queste costituiscono la realtà profonda o sono soltanto pezzi di un regolamento che ci siamo dati per organizzare meglio la nostra conoscenza del mondo? o semplici paletti che piantiamo e ci lasciamo alle spalle come segnali via via che procediamo nella giungla dell’esperienza? È possibile che non esistano affatto leggi di natura? Forse esse, e anche l’universo che da esse sembra regolato, sono del tutto creazioni della nostra mente: un’illusione che scompare appena cessiamo di pensarvi. Ma allora, che cosa accadrebbe, se non ci fossero osservatori dell’universo?». Interrogativi di questo genere, che incontriamo sulla soglia del Mondo dentro il mondo, sarebbero suonati eccentrici fino a qualche anno fa. Oggi, al contrario, circ...

  10. Corrélats du bien-être chez les Canadiens présentant des troubles de l’humeur ou d'anxiété

    Directory of Open Access Journals (Sweden)

    H. Orpana

    2016-01-01

    déclarer également des scores de bien-être plus élevés. Cette étude a fourni des données probantes à partir d’un échantillon représentatif de la population montrant qu’il est possible de vivre dans un état de bien-être même en présence d’un trouble de l'humeur ou d'anxiété.

  11. Atributos característicos de las marcas de bienes de lujo Atributos característicos de las marcas de bienes de lujo

    Directory of Open Access Journals (Sweden)

    Carlos Mario Uribe Saldarriaga

    2006-06-01

    Full Text Available Este artículo presenta una síntesis de la investigación desarrollada por el autor como trabajode grado en el Magíster en Ciencias de la Administración de la Universidad EAFIT. La investigación se centra en la identificación y comprensión de los atributos que caracterizan a las marcas de bienes reconocidas como de lujo, mediante la aplicación de la metodología de investigación denominada análisis de contenido, a una muestra de conveniencia de sitios web de dichas marcas. La investigación se circunscribe al ámbito de estudio del mercadeo y utiliza sus diferentes conceptos para determinar tanto el marco de referencia como la caracterizaciónde los atributos de las marcas de bienes de lujo.This article is a synthesis of the research study conducted by the author as a requirement for the MSc in Management at EAFIT University. The objective in this research is to identify and understand the attributes that characterize brands, acknowledged as luxury goods. The content analysis was chosen as the research method for studying a convenience sample of luxury brand sites on the Internet.  This research study is developed in the marketing field, and its different concepts were adopted as the reference framework.

  12. La publicidad de bien público y la educación sexual en Cuba

    OpenAIRE

    Hernández Alfonso, Eduardo Alejandro; Paz Enrique, Luis Ernesto

    2016-01-01

    La prevención es una premisa de la educación en salud cubana. Se plantean como objetivos del estudio identificar las características del diseño gráfico cubano para la prevención de las ITS y diseñar una propuesta de bien público basado en nuevos criterios estéticos. El estudio clasifica como investigación aplicada. Se utilizan métodos en los niveles teóricos y empíricos para la recogida de información. La investigación analiza las campañas de bien público orientadas a la prevención de las inf...

  13. Le « bien-être animal », pourquoi pas ?

    OpenAIRE

    Priolon, Joël

    2011-01-01

    À moins d’être parfaitement insensible au sort réservé aux animaux sauvages ou domestiques, chacun de nous est intéressé par la question du bien-être animal. Être intéressé, et c’est d’emblée un point essentiel, n’implique pas de sombrer dans la passion. Posons donc ceci : la question du bien-être animal peut parfaitement être abordée de manière sereine, ce que Jocelyne Porcher semble nier dès son premier paragraphe ; mais nous ne nous laisserons pas enfermer dans ce type de stratagème rhétor...

  14. Usurpaciones de bienes concejiles en Salamanca durante el Reinado de los Reyes Católicos

    Directory of Open Access Journals (Sweden)

    Clara Isabel LÓPEZ BENITO

    2009-12-01

    Full Text Available La realidad económica-social castellana de la Edad Moderna se caracterizó por ser fundamentalmente agraria. Un porcentaje muy elevado de la población activa del Reino trabajaba en el campo, y de él procedía el grueso de las rentas que sustentaban la vida nacional. En la mayoría de los municipios castellanos, junto a las posesiones particulares y junto a aquellas otras que teóricamente pertenecían al rey, existieron las llamadas "tierras concejiles" (o "comunitarias" como prefieren otros autores. Dentro de ellas había que distinguir los "bienes comunales", libremente aprovechados por los vecinos del término municipal, y los "bienes de propios", que el concejo alquilaba a particulares a cambio de una renta que resolvía diversos gastos de la Administración local.

  15. EL PATRIMONIO COMO REPRESENTACIÓN COLECTIVA: LA INTANGIBILIDAD DE LOS BIENES CULTURALES

    Directory of Open Access Journals (Sweden)

    Javier Marcos Ar\\u00E9valo

    2012-01-01

    Full Text Available Enfocado desde la perspectiva de la antropología social, el artículo se estructura en torno a los conceptos de tradición, bienes culturales intangibles y representación de la memoria social. Desde planteamientos críticos el trabajo revisa textos fundamentales y analiza y valora los documentos que sobre patrimonio inmaterial ha hecho público la UNESCO en los últimos quince años.

  16. Sobre el desarrollo de la teoría de los bienes públicos locales

    Directory of Open Access Journals (Sweden)

    Miltón Samuel Camelo

    2015-12-01

    Full Text Available La teoría de los bienes públicos locales toma forma desde la concepciónde la hipótesis de Tiebout, que es el primer planteamiento que tuvo en cuentala dimensión espacial de los bienes públicos, y constituye un mecanismo para la revelación de las preferencias sobre este tipo de bienes. Este trabajo desarrolla la analogía entre el modelo de Tiebout y el modelo neoclásico como una herramienta de dirección del trabajo y no como fin mismo pues, de lo contrario, puede terminar en una discusión ideológica que no es pertinente. Se examina el desarrollo de la teoría a través de la revisión de tópicos relevantes y aportes que han enriquecido y complementado el modelo de Tiebout; y, finalmente, describe elementos esenciales que debe incorporar la teoría para que tenga un mayor poder explicativo.

  17. Producir conocimiento: una discusión entre la propiedad privada y los bienes comunes

    Directory of Open Access Journals (Sweden)

    Beatriz H. Amador Lesmes

    2014-02-01

    Full Text Available El artículo presenta un análisis sobre el fortalecimiento de los dispositivos globales de control en Colombia representados en los sistemas de información de Colciencias. Este hecho habría llevado a su naturalización en las prácticas de los investigadores condicionando las formas de investigar y producir conocimiento. Se busca señalar que estos dispositivos operan a favor de una racionalidad global hegemónica en la cual los bienes intelectuales se asumen y se tratan como bienes privados y objetos del mercado. Esta se contrasta con algunas prácticas emergentes donde la producción de bienes intelectuales se genera a partir de otras lógicas que comprenden el trabajo en relación con la cooperación y la creatividad, desde lo que Virno y Lazzarato llaman trabajo vivo, en especial a través de los usos de Internet.

  18. Autorización para la venta de los bienes de propiedad de los menores de edad en sede notarial

    OpenAIRE

    Corrales León, Jaime Augusto

    2016-01-01

    Por disposición de la ley, los bienes del menor deben ser conservados ante la imposibilidad de su titular para decidir sobre los mismos; es así que el artículo 297 del Código Civil establece que “No se podrán enajenar ni hipotecar en caso alguno los bienes raíces del hijo, aún pertenecientes a su peculio profesional, sin autorización del juez, con conocimiento de causa”. Los padres quienes ejercen la patria potestad sobre el hijo menor de edad o aquel que administre los bienes por mandato ...

  19. OF THE COMMON GOOD TO THE COMMON GOOD OF HUMANITY. DE LOS BIENES COMUNES AL BIEN COMÚN DE LA HUMANIDAD.

    Directory of Open Access Journals (Sweden)

    François Houtart.

    2014-06-01

    éndum sobre el agua (uno de los bienes comunes en Italia, la Fundación Rosa Luxemburgo tomó la decisión de organizar una Conferencia sobre el concepto del Bien Común de la Humanidad, para promover una reflexión sobre los vínculos entre las dos nociones y de integrar las reivindicaciones y las luchas sociales para un cambio de sociedad, escenario en el que se enmarca éste artículo.

  20. Food as a source of dioxin exposure in the residents of Bien Hoa City, Vietnam.

    Science.gov (United States)

    Schecter, Arnold; Quynh, Hoang Trong; Pavuk, Marian; Päpke, Olaf; Malisch, Rainer; Constable, John D

    2003-08-01

    Recently, elevated dioxin levels, over 5 parts per trillion (ppt) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), from Agent Orange was reported in 95% of 43 selected residents of Bien Hoa City, a city in southern Vietnam near a former air base used for Agent Orange-spraying missions. Agent Orange herbicide, contaminated with TCDD, was sprayed in Vietnam between 1962 and 1971 primarily for use as a defoliant. Typical blood TCCD levels are 2 ppt in Vietnamese, but levels are as high as 413 ppt in Bien Hoa City. Elevated TCDD was found in children born many years after Agent Orange spraying ended and in immigrants from non-Agent Orange-sprayed parts of Vietnam, which documented new exposures. Extremely elevated soil TCDD samples, over 1 million ppt, and elevated TCDD in sediment were found in some nearby areas such as Bien Hung Lake. The primary route of intake of almost all dioxins in humans is food. However, in our prior studies in Bien Hoa, food was unavailable for dioxin analysis so the route of intake was not confirmed. In the 1970s, while Agent Orange was still being sprayed, elevated human milk TCDD levels as high as 1850 were detected in milk from Vietnamese people living in Agent Orange-sprayed areas where consumption of fish was high. Furthermore, also in the 1970s, elevated TCDD levels (up to 810 ppt) were found in fish and shrimp from the same area as the milk donors. In the 1980s, we found elevated TCDD and also other organohalogen levels in human tissue, pork, fish, a turtle, and a snake in Southern Vietnam. For these reasons, we recently collected food from Bien Hoa and analyzed it for dioxins, polychlorinated biphenyls (PCBs), DDT and its metabolites, and other organochlorines. We found marked elevation of TCDD, the dioxin characteristic of Agent Orange, in some of the food products, including ducks with 276 ppt and 331 ppt wet weight, chickens from 0.031-15 ppt wet weight, fish from 0.063-65 ppt wet weight, and a toad with 56 ppt wet weight. Usual TCDD

  1. Los Bienes Destinados al Uso General: Tratamiento Contable en Diferentes Administraciones Locales Europeas

    Directory of Open Access Journals (Sweden)

    María Teresa Balaguer Coll

    2001-06-01

    Full Text Available Como respuesta a la necesidad de una mayor información para la gestión, los sistemas contables públicos han sido sometidos a un proceso general de reforma, especialmente en la administración local. Estas reformas afectan, entre otros, al tratamiento contable de los activos fijos. Dada la especial naturaleza que poseen algunos de estos activos, como es el caso de los bienes destinados a uso general, este artículo tiene por objeto analizar la problemática contable que tales bienes originan, mostrando diferentes posturas académicas y las prácticas contables de las entidades locales en diferentes países europeos. En general, se aprecia una clara tendencia a la presentación de mayor información sobre el activo fijo en los estados financieros, siendo el criterio de valoración más utilizado el coste histórico. Palabras clave: bienes de uso general, contabilidad pública, entidades locales europeas. ABSTRACT In response to the need for better management information, pubic sector accounting systems have been subjected to a general reform process, especially in local government. These reforms cover, among other things, accounting for capital assets. Given the special nature of some of these assets, such as community assets, this article aims to analyse the problematic roots of accounting, examining different academic positions as well as the accounting rules and practices of local authorities in different European countries. In general, there appears to be a clear tendency to present more information on capital assets in financial statements, with historic cost being the most utilised valuation criteria.

  2. El bien vivir: ¿cuidado de la salud o proyecto vital? Segunda parte

    OpenAIRE

    Leonardo Viniegra Velázquez

    2016-01-01

    El sentido de la vida, la razón profunda del anhelo de vivir y la motivación para actuar en consecuencia, es el antecedente del proyecto vital (PV). Se argumenta cómo la lucha por la dignidad es el verdadero derrotero de superación de la condición humana y el eje de PV que aspiran al bien vivir. El PV que se propone es una aventura cognitiva que trasciende el consumismo, el individualismo y la pasividad en la búsqueda de otro mundo hospitalario e incluyente, donde tenga viabilidad la super...

  3. Die biene und ihre produkte in der kunst und im alltagsleben (Fruhchristliche und byzantinische Zeit

    Directory of Open Access Journals (Sweden)

    Liveri Angeliki

    2010-01-01

    Full Text Available Die vorliegende Arbeit ist in zwei Teile geteilt: den kunst- und kulturhistorischen Teil. Im ersten Teil werden Darstellungen uber Bienen Bienenzucht, Honig und Wachs seit der fruhchristlichen bis zur spatbyzantinischen Zeit vorgefuhrt. Daher ist es als Beitrag in der "Ikonographie" der Biene wahrend dieser Zeit zu verstehen. Im kulturhistorischen Teil werden Informationen uber die Bienenzucht, den Handel mit Honig und Wachs sowie ihre vielfaltige Anwendung von der byzantinischen Gesellschaft an Hand der primaren Quellen, des Standes der Forschung und der archaologischen Funden erwahnt. Damit ist erwunscht ein moglichst gutes Bild der byzantinischen Bienenzucht wieder zu geben und die Nutzung der Bienenprodukte in Byzanz anschaulich zu machen.

  4. Priorización Ejidal De Criterios Sobre Bienes Públicos: El Caso De Caminos Rurales

    OpenAIRE

    Morales Flores, Francisco Javier; Martín Fernández, Susana; Cadena Iñiguez, Jorge

    2011-01-01

    En este artículo se fijó como objetivo definir las preferencias de la población sobre el mantenimiento de los caminos rurales como vías de flujo de bienes y servicios que usan cotidianamente, para ello se presenta un modelo de participación de la sociedad rural donde se integra la opinión de los beneficiarios en el mantenimiento de los caminos rurales basado en un proceso de análisis jerárquico que valora la importancia de criterios económicos, sociales y ambientales

  5. La promesa de compraventa de bienes inmuebles y el derecho de propiedad

    OpenAIRE

    Salazar Gaspar, Jimmy Roman

    2015-01-01

    El contrato de promesa de bienes inmuebles en la legislación ecuatoriana, es un instrumento fundamental e indispensable en el ámbito económico jurídico y social de las personas, por lo cual resulta evidente y necesario revisar la normativa y su aplicación en el derecho ecuatoriano. En los juzgados y Salas de administración de justicia existe un número alarmante de demandas por incumplimiento o ineficacia de la promesa de compraventa, que obedece a factores propios de los contratantes y a l...

  6. El reconocimiento de los bienes de dominio público: El caso de los municipios portugueses

    Directory of Open Access Journals (Sweden)

    Susana Catarino Rua

    2016-02-01

    Full Text Available Objeto: Este trabajo tiene por objetivos analizar el mencionado en el POCAL (1999, en las NICSP del IPSASB y en diversas opiniones doctrinales con respecto al reconocimiento de los bienes de dominio público (BDP, así como verificar si existen problemas inherentes al reconocimiento de los BDP en Portugal, superables con la adopción de las NICSP. Diseño/metodología/Enfoque: Para este estudio, fue efectuada una revisión de literatura, de la posición del POCAL (1999, de las NICSP del IPSASB, y de la perspectiva doctrinal, con respecto al reconocimiento de los bienes de dominio público. Además, se realizó un estudio de la evolución de los valores de los bienes de dominio público, de los años 2006 a 2013, del total de los 308 municipios portugueses, para concluir acerca de la existencia de dificultades en el reconocimiento de estos activos y de la necesidad de adoptar los normativos internacionales. Aportaciones y Resultados: En algunos municipios portugueses, el proceso de inventario aún no está concluido, existiendo dificultades con respecto al reconocimiento de los BDP. Dichas dificultades resultan de que el POCAL (1999 no presenta los requisitos para el reconocimiento de los activos; problema superado en la NICSP nº 17 del IPSASB (2006b, que refiere esos requisitos. Adoptar un nuevo Sistema de Normalización Contable aplicable a la Administración Pública (SNC-AP, basado en las NICSP, puede ser la solución para dichas cuestiones, introduciendo criterios a considerar en el reconocimiento de los activos, que aseguren la comparabilidad de la información y de los valores del patrimonio de los municipios portugueses. Limitaciones: La inexistencia de criterios de reconocimiento a seguir por los municipios trae limitaciones al nivel de la comparabilidad de los valores de los diferentes componentes del activo presentados por los varios municipios. Valor añadido: Este trabajo nos enseña que, en Portugal, aún existen problemas con

  7. Il secondo principio

    CERN Document Server

    Atkins, Peter W

    1988-01-01

    L'asimmetria della Natura ; l'indicatore di una trasformazione ; scivolando verso il caos ; la quantificazione del caos ; la potenzialità del caos ; le trasformazioni del caos ; il dominio della temperatura ; caos costtrutivo ; le strutture del caos.

  8. Memoria sobre la Red de Estudio y Enseñanza Interdisciplinar del Gobierno del Bien Común

    OpenAIRE

    2015-01-01

    El presente trabajo en red docente ha servido para cuestionar y proponer la reformulación de la enseñanza y la investigación universitaria a partir del “gobierno del bien común”. Desde la Red se ha pretendido reformular el concepto de “bien público” como “bien común” para recalcar el uso común de dichos bienes y la necesidad de su conservación en buen estado para asegurar dicho uso, y evitar las peligrosas “privatizaciones encubiertas”. De ahí que nuestra Red a través de sus distintas discipl...

  9. Diálogos entre feminismos y Buen Vivir/Vivir Bien : distintas perspectivas, múltiples puntos de encuentro

    OpenAIRE

    2013-01-01

    Este artículo surge del diálogo entre distintos saberes y conocimientos, con el objetivo de identificar principalmente las convergencias entre el Buen Vivir/Vivir Bien y los feminismos latinoamericanos. Iniciamos este trabajo considerando las ideas centrales del enfoque del Buen Vivir/Vivir Bien y sus mecanismos de traducción concreta en las reformas constitucionales de Bolivia y Ecuador. Luego, nos detenemos en las confluencias –aunque identificando al...

  10. Restauración del Capital Natural: sin reservas no hay bienes ni servicios

    Directory of Open Access Journals (Sweden)

    J. Aronson

    2007-01-01

    Full Text Available Una de las ideas más innovadoras y atractivas que se están acuñando en la actualidad está relacionada con la necesidad que tiene la humanidad de preservar y manejar los recursos naturales o capital natural - remanente e invertir en la restauración del capital natural (RCN degradado para reincorporarlo a la cadena de bienes y servicios que la sociedad requiere. En este artículo, presentamos definiciones y conceptos básicos, para mostrar como la RCN es un enfoque más amplio en relación al propuesto en la restauración ecológica de ecosistemas naturales. Damos a conocer estudios de caso, como ejemplos del enfoque de la RCN, y su impacto sobre el suministro de bienes y servicios en Argentina, Colombia, México y Chile. Terminamos con una breve discusión y algunas recomendaciones para la investigación y el desarrollo de la RCN a nivel local, regional y global.

  11. TNFα/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction

    OpenAIRE

    Badalyan, Vahe; Addo, Kezia; Thompson, Robert W.; Borthwick, Lee A.; Fisher, Andrew J.; Ort, Tatiana; Myers, Timothy G.; Thomas A Wynn; Ramalingam, Thirumalai R.

    2014-01-01

    IL-17 and TNFα synergistically induce surface expression of IL-13Rα2 on primary lung fibroblasts, rendering them unresponsive to IL-13. Neutralizing antibodies to IL-13Rα2 restored IL-13-mediated signaling and transcriptome studies confirmed IL-13Rα2 is an IL-13 decoy receptor.

  12. Il codice Pontecorvo

    Directory of Open Access Journals (Sweden)

    Sergio Di Lino

    2016-07-01

    Full Text Available Gli ultimi lavori di Pontecorvo, dopo il congedo dal cinema pensato per il grande schermo avvenuto con Ogro. Una serie di documentari, perlopiù regie collettive dal taglio politico e militante, con l’eccezione del cortometraggio Nostalgia di protezione. Il successo di Un altro mondo è possibile, il film sul G8 di Genova del 2001. L’addio definitivo, e il simbolico passaggio del testimone con suo figlio Marco. Esiste un “lascito” cinematografico del regista? L’influenza sul cinema americano contemporaneo, dalla New Hollywood in poi, e qualche equivoco. Alcuni possibili “eredi”, in Italia e all’estero.

  13. Achats de biens et services des organisations internationales dans les pays industrialisés et les économies émergentes

    Directory of Open Access Journals (Sweden)

    Gilles Carbonnier

    2013-08-01

    Full Text Available Cet article examine l’évolution des achats de biens et services des organisations multilatérales auprès de fournisseurs établis dans les pays industrialisés et les économies émergentes. Il présente les résultats d’une étude empirique – première du genre – sur les facteurs explicatifs des inégalités entre pays. Les différences s’expliquent notamment par la force du secteur manufacturier et les relations d’affaires établies dans le passé. Les résultats laissent penser que les contributions versées par les pays donateurs peuvent avoir une influence positive sur les achats de biens et services, nonobstant le fait que les organisations multilatérales recourent à des procédures d’appels d’offres internationaux. La proximité géographique, les affinités culturelles et linguistiques et la présence dans le pays du siège d’une organisation multilatérale jouent également un rôle positif. Les achats de biens et services des agences multilatérales peuvent être considérés comme une retombée indirecte de l’aide publique au développement (APD. Alors que nombre d’entre eux font face à de sérieuses difficultés économiques et contraintes budgétaires, documenter un tel « retour sur investissement » peut contribuer à convaincre les décideurs politiques d’augmenter – ou simplement de ne pas réduire – les budgets d’APD. De tels arguments doivent toutefois demeurer marginaux par rapport aux questions centrales de la pertinence et l’efficacité de l’aide, et des performances des organisations multilatérales.

  14. The global warming, public goods and carbon market; Calentamiento global, bienes publicos y mercado de carbono

    Energy Technology Data Exchange (ETDEWEB)

    Quadri de la Torre, Gabriel [EcoSecurities (Mexico)

    2007-07-15

    The global warming is an issue of the public goods, and demands an outstanding multilateral action, which must to ensure both efficiency and unchanging transition towards an economy of low intensity of carbon. The new system, which is going to replace the Kyoto Protocol, will have compromises for the developing countries and deep implication in the relative competitivity of the nations and companies. [Spanish] El calentamiento global es un problema de bienes publicos que exige una extraordinaria accion multilateral. Esta debe asegurar eficiencia y una transicion fluida hacia una economia de baja intensidad de carbono. El nuevo sistema que sucedera al Protocolo de Kyoto significara compromisos para los paises en vias de desarrollo, y tendra profundas implicaciones en la competitividad relativa de naciones y empresas.

  15. El Régimen Fiscal de los bienes de la Iglesia durante el siglo IV

    OpenAIRE

    Santos Yanguas, Narciso

    2011-01-01

    El patrimonio de la Iglesia, aunque remonta en sus orígenes a las comunidades cristianas de los 3 primeros siglos, no tendría un reconocimiento oficial hasta la época de Constantino. A continuación lo consolidaría el emperador Constancio II mediante la aplicación de exenciones fiscales. Dicho patrimonio se incrementaría a través de la apropiación de los templos paganos y de sus bienes, a pesar de la fase de regresión que supone la época de Juliano (361-363). A lo largo del siglo IV el Códi...

  16. El bien vivir: ¿cuidado de la salud o proyecto vital? Primera parte

    Directory of Open Access Journals (Sweden)

    Leonardo Viniegra-Velázquez

    2016-03-01

    La influencia de la medicalización en el modo de vivir ha convertido la obsesión por estar sano y el horror a la enfermedad en un medio de control social al servicio del poder que mantiene y profundiza las desigualdades; de ahí su promoción incesante. Se arguye cómo esa preocupación por la salud, lejos de aproximar al bien vivir, introduce por senderos de angustia, inseguridad y desasosiego. Al final, se hacen consideraciones sobre los inconvenientes de que el cuidado de la salud polarice la atención y las energías vitales de los profesionales de la salud y de los usuarios de los servicios, y se descuide la responsabilidad ética, que atañe a todos, de la búsqueda de un mundo hospitalario e incluyente.

  17. Evolución y factores del consumo de bienes duraderos en tiempos de crisis prolongadas

    Directory of Open Access Journals (Sweden)

    Víctor Omar Dabbagh Rollán

    2015-01-01

    Full Text Available En las llamadas sociedades de consumo, como es el caso de la española, el elemento sustentador de la misma es el propio consumo. Es por ello que se vuelve imprescindible en situaciones de crisis económica como la actual analizar cómo evoluciona el mismo y determinar qué factores intervienen en él con el fin de prever futuros comportamientos e, incluso, tomar medidas para incentivar aquellos que se considere más oportuno. En este estudio, a partir del estudio de la encuesta del Indicador de Confianza del Consumidor del CIS, se pretende analizar estos aspectos en el consumo de bienes duraderos que se realiza en España en los dos últimos años.

  18. Public health assessment of dioxin-contaminated fish at former US airbase, Bien Hoa, Vietnam.

    Science.gov (United States)

    Durant, James T; Boivin, Thomas G; Pohl, Hana R; Sinks, Thomas H

    2015-01-01

    Ponds at the former US airbase at Ben Hoa, Vietnam are contaminated with Agent Orange. The ponds had been used for aquaculture, and in all likelihood, fish from those ponds have been sold to the public. We assessed human exposure to 2,3,7,8-tetrachloro-dibenzo-dioxin (2,3,7,8-TCDD) in fish samples from the ponds. For on-base tilapia, muscle concentrations 2,3,7,8-TCDD ranged from 1.4 to 32.7 pg/g. Fat concentrations ranged from 73.3 to 3990 pg/g. Estimated human exposure doses exceed international guidelines and exceed 2,3,7,8-TCDD's lowest adverse effect levels. The Bien Hoa fishponds are a completed human pathway for TCDD exposure.

  19. Codicia y bien público: los ministros de la Audiencia en la Lima seiscentista

    Directory of Open Access Journals (Sweden)

    de la Puente Brunke, José

    2006-04-01

    Full Text Available The Administration agent was a complex figure in Colonial Peru. This article aims to discuss that complexity, focusing its analysis on the Ministers of Lima’s Audiencia during the Seventeenth century. The concepts of greed (codicia and public good (bien público will be considered in that context, posing some ideas concerning the peculiar way of «selling» judicial posts, known as beneficio. The activities of some of the Audiencia’s Ministers in Lima will be discussed, trying to offer more references on their role in the viceregal society, as well as on their contemporaries’ perception regarding them.

    El presente artículo pretende ofrecer una visión de la complejidad de la figura del agente de la administración pública en el Perú virreinal, centrando su análisis en los ministros de la Audiencia de Lima en el siglo XVII. Como punto de partida, se presentan testimonios a través de los cuales se percibe la tensión entre la «codicia» y el «bien público», y en ese contexto se plantean algunas reflexiones sobre el beneficio de oficios de justicia. Luego se analizan las actividades de algunos de esos ministros en la Lima de entonces, y se busca ofrecer mayores referencias con respecto a su papel en la sociedad virreinal, y en cuanto a la visión que sobre ellos tenían sus contemporáneos.

  20. Bienestar subjetivo, renta y bienes relacionales. Los determinantes de la felicidad en España

    Directory of Open Access Journals (Sweden)

    Iglesias Vázquez, Emma

    2013-12-01

    Full Text Available In the present paper we analyze the determinants of happiness proxying by subjective welfare. The main objective is twofold: on the one hand, to put to the test the Easterlin’s paradox (the lack of a direct relationship between income and subjective wellbeing at aggregate level and, on the other hand, to weight influence of relational goods in determining happiness. The analytical framework adopts the perspective of happiness economics and the empirical evidence is derived from the estimation of a microeconometric function of happiness applying a Logit model both when using cross sectional and panel data. The results show that in Spanish society income plays a secondary and subjective role, while other variables that are associated directly or indirectly to relational goods are revealed to be very important.En el presente trabajo se analizan los determinantes de la felicidad, entendida esta como satisfacción subjetiva revelada. El principal objetivo tiene un doble componente: por un lado, se trata de contrastar la paradoja de Easterlin para la sociedad española (ausencia de un vínculo directo entre el incremento de la renta per capita y la evolución del bienestar subjetivo revelado a nivel agregado y, por otro, evaluar el papel que desempeñan los bienes relacionales como determinantes de la felicidad. El marco analítico adoptado se encuadra dentro de la denominada happiness economics y la evidencia empírica se deriva de la estimación de una función microeconométrica de la felicidad aplicando un modelo Logit tanto en cortes temporales como en datos de panel. Los resultados obtenidos permiten concluir que en España el ingreso desempeña un papel secundario y subjetivo, mientras que se revelan como importantes las variables asociadas directa o indirectamente a los bienes relacionales.

  1. Il toponimo friulano Nimis

    Directory of Open Access Journals (Sweden)

    Roberto Gusmani

    2009-12-01

    Full Text Available Il contributo si concentra sull'origine del toponimo Nimis, località a nord di Udine, il cui nome è attestato per la prima volta in Paolo Diacono. Per quanto riguarda l'etimo, l'unico in circolazione risulta esser quello proposto da F. Schürr (1930, secondo il quale il toponimo friulano risalirebbe ad una forma celtica affine alla denominazione in età classica della città di Nîmes (provenzale Nemse, cio è Nemausus. Contrariamente a tale interpretazione, l'autore raccoglie indizi a favore dell'eventualità che il toponimo sia di origine slava, riconducendolo ad un prototipo paleoslavo němici. La forma Nimis sarebbe il risultato della 'friulanizzazione' del lessema slavo presente nel dialetto sloveno della valle del Torre situata a poca distanza dalla località friulana in questione.

  2. Il problema del litio.

    Science.gov (United States)

    D'Antona, F.

    1995-03-01

    Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari più minuscoli. 11. Conclusioni.

  3. Il muro come galleria

    Directory of Open Access Journals (Sweden)

    Duccio Dogheria

    2008-06-01

    Full Text Available Il muro, nel suo grigio rigore formale, nella sua fredda geometria, nel suo intento divisorio, nasconde spesso il cielo. Sovente il linguaggio dell’arte, ma non di meno quello della comunicazione, hanno interferito con le sue algide barriere. In molti casi, beninteso, non è che il potere in altre forme, che interferisce con se stesso: pensiamo ai bandi affissi agli angoli delle città, o le lettere d’indulgenza papali -spesso impreziosite da miniature al punto da poterle considerare antenate dal manifesto- che nel corso del medioevo venivano affisse sulle porte delle chiese.

  4. IL POETA E IL SUO TEMPO

    Directory of Open Access Journals (Sweden)

    Cheick Tidiane Gay

    2014-02-01

    Full Text Available La letteratura ha una funzione etica cui non può rinunciare. Il letterato, la figura più importante su un territorio, ha il compito di leggere la realtà, di interpretarla, di comunicarla. È il faro che si deve accendere e guidare le azioni degli uomini: un popolo che rinuncia ai suoi letterati e all’etica della letteratura, è un popolo che si perde. Così egli canta la Negritudine, la storia e il dolore della sua gente; e la sua poesia, con un forte impegno civile, si propone di dar voce a chi non ce l’ha.  The poet and his times Literature has an undeniable ethical function. The writer, the most important figure in a place, has the task of reading, interpreting and communicating reality. Literature is the beacon that one turns to and that guides the actions of people. A country that renounces its writers and the ethics of literature is a lost nation. Thus the writer sings of Negritude, the history and the pain of his people. Her poetry, with strong social commitment, aims to give voice to those who do not have one.

  5. Valuación de Bienes de Uso en el Marco de las Nuevas Normas Contables Profesionales

    OpenAIRE

    2005-01-01

    Respecto a la valuación de los Bienes de Uso el abandono de los valores corrientes, reemplazado por valores históricos, sacrifica los requisitos de aproximación a la realidad, verificabilidad y confiabilidad de la información. Al mismo tiempo, se contradice con Normas Internacionales de Contabilidad (IAS) hacia las que supuestamente buscaba armonizar, ya que éstas (IAS 16) admiten revalorizaciones y desvalorizaciones, con énfasis en mostrar, en todo momento, el fair value de los Bienes de Uso...

  6. Variables del capítulo IV en ISR para la enajenación de bienes inmuebles

    OpenAIRE

    Ochoa León, Jorge

    2011-01-01

    Nuestro trabajo pretende orientar e identificar cuales son las obligaciones y responsabilidades del contribuyente para calcular los impuestos que se causen, tanto en sus pagos provisionales como en la declaración anual, conforme a la ley del impuesto sobre la renta y las diversas disposiciones reglamentarias, que son aplicables en la enajenación de bienes inmuebles. En el cálculo del impuesto por la enajenación de bienes inmuebles, nos damos cuenta de que la responsabilidad no es solo del con...

  7. La elasticidad precio del café mexicano: un modelo para una canasta de bienes, 1976-2000

    OpenAIRE

    2004-01-01

    Plantea el problema de la estimación de las elasticidades precio de la demanda marshalliana, para cualquier bien a partir de canastas de bienes interdependientes y se hace una aplicación al caso del café mexicano, en el periodo 1976-2000. Desde la formulación del concepto de elasticidad por Alfred Marshall en 1886 hasta la actualidad, se ha dado un notable desarrollo en los métodos de estimación. En este artículo se utilizó el Modelo de Demanda Casi Ideal (Almost Ideal Demand System o AIDS) q...

  8. IL-32 promotes angiogenesis

    NARCIS (Netherlands)

    Nold-Petry, C.A.; Rudloff, I.; Baumer, Y.; Ruvo, M.; Marasco, D.; Botti, P.; Farkas, L.; Cho, S.X.; Zepp, J.A.; Azam, T.; Dinkel, H.; Palmer, B.E.; Boisvert, W.A.; Cool, C.D.; Taraseviciene-Stewart, L.; Heinhuis, B.; Joosten, L.A.; Dinarello, C.A.; Voelkel, N.F.; Nold, M.F.

    2014-01-01

    IL-32 is a multifaceted cytokine with a role in infections, autoimmune diseases, and cancer, and it exerts diverse functions, including aggravation of inflammation and inhibition of virus propagation. We previously identified IL-32 as a critical regulator of endothelial cell (EC) functions, and we n

  9. Il cervello Qualitativo

    Directory of Open Access Journals (Sweden)

    Davide Liccione

    2012-04-01

    Full Text Available Il cervello qualitativo: senso comune, cervello e fallacia mereologica. Capita frequentemente di leggere articoli neuroscientifici nei quali si trovano frasi del tipo: “il neurone vede”, “il cervello pensa”, “i lobi frontali decidono”. Ad esempio, secondo F. Crick (2005: “What you see is not what is really there; it is what your brain believes is there”, oppure, secondo B. Libet (1985 “the brain decides to initiate or, at least, to prepare to initiate the act before there is any reportable subjective awareness that such a decision has taken place” (cit. in Bennett et al, 2007. Quest’aspetto del linguaggio neuroscientifico è stato accusato di fallacia mereologica. La mereologia è la logica delle relazioni tra il tutto e le parti (mereos = “parte”. Secondo i fautori della fallacia mereologica, quando il neuroscienziato (o lo psicologo, il filosofo ecc. asserisono che il cervello pensa, stanno commettendo l’errore di riferire attributi psicologici che riguardano l’individuo (esemplare non ripetibile e non divisibile senza alterazione a una sua specifica parte (il cervello.

  10. IL-32 promotes angiogenesis

    NARCIS (Netherlands)

    Nold-Petry, C.A.; Rudloff, I.; Baumer, Y.; Ruvo, M.; Marasco, D.; Botti, P.; Farkas, L.; Cho, S.X.; Zepp, J.A.; Azam, T.; Dinkel, H.; Palmer, B.E.; Boisvert, W.A.; Cool, C.D.; Taraseviciene-Stewart, L.; Heinhuis, B.; Joosten, L.A.; Dinarello, C.A.; Voelkel, N.F.; Nold, M.F.

    2014-01-01

    IL-32 is a multifaceted cytokine with a role in infections, autoimmune diseases, and cancer, and it exerts diverse functions, including aggravation of inflammation and inhibition of virus propagation. We previously identified IL-32 as a critical regulator of endothelial cell (EC) functions, and we

  11. Pensare con il cuore

    Directory of Open Access Journals (Sweden)

    Laura Boella

    2008-07-01

    Si delinea così il rapporto fra l'io e il tu che, nella persona umana, costituisce l'essere come amore, in quanto la persona si viene costruendo a partire essenzialmente dall'incontro, secondo la logica della relazione che si rivela appunto come logica dell'amore.

  12. Marketing; Il marketing

    Energy Technology Data Exchange (ETDEWEB)

    Muscigna, M. [ENEA, Centro Ricerche Casaccia, S. Maria di Galeria, RM (Italy). Dipt. Innovazione

    1999-07-01

    The report discusses marketing strategies oriented to the organizations and analyzes its critical factors, which determine the success of the organization activity. [Italian] Il rapporto analizza i caratteri delle strategie del marketing orientato all'impresa. Vengono infine analizzati i fattori critici che determinano il successo o l'insuccesso delle scelte aziendali.

  13. Novel biologic therapies in development targeting IL-12/IL-23

    NARCIS (Netherlands)

    Kerkhof, P.C.M. van de

    2010-01-01

    Recent research has identified the importance of interleukin 12 (IL)-12 and IL-23 in the immunopathogenesis of psoriasis. The p40 subunit common to IL-12 and IL-23 is an attractive target for selective therapy. Clinical study data are available for two anti-IL-12/23 therapies: ustekinumab (CNTO

  14. Effect of TGF-β1 on the Expression of IL-12, IL-15, IL-18, IL-4 and IL-10 in Heart Transplantation Rejection in Rats

    Institute of Scientific and Technical Information of China (English)

    ZHAO Jinping; LI Ping; GAO Sihai; WANG Xianguo; GAO Xiaojian

    2007-01-01

    To investigate the effect of TGF-β1 on the expressions of IL-12, IL-15, IL-18, IL-4 and IL-10 in heart transplantation rejection in rats, a model of rat cervical heterotopic heart transplanta-tion was set up and the model rats were randomly divided into three groups: control group, transplant group and TGF-β1 group. The mRNA expression levels of IL-12, IL-15, IL-18, IL-4 and IL-10 were determined by RT-PCR at the 5th day after the transplantation. The mRNA expression levels of IL-12,IL-15, IL-18 were increased obviously and those of IL-4, IL-10 were significantly decreased in the transplant group as compared with the control group (P<0.01). In the TGF-β1 group, the mRNA ex-pression levels of IL-12, IL-15, IL-18 were significantly decreased and those of IL-4, IL-10 were sig-nificantly increased as compared with the transplant group (P<0.01). The immunosuppressive effect of TGF-β1 on heart transplantation rejection was related to its inhibition of the expressions of Th1-type cytokines (IL-12, IL-15, IL-18 etc) and its promotion of the expressions of Th2-tpye cyto-kines (IL-4, IL-10).

  15. Reflexiones en torno a la división de los bienes públicos en el código civil

    Directory of Open Access Journals (Sweden)

    Julián Andrés Pimiento Echeverri

    2011-12-01

    Full Text Available El estudio de la naturaleza y del régimen de los bienes públicos en el derecho colombiano ha estado marcado por la clásica distinción de los mismos realizada por el Código Civil. Este artículo pretende demostrar que dicha clasificación se encuentra superada, en la actualidad, por la realidad de su desarrollo legislativo y por la necesidad de una gestión más eficiente de los patrimonios públicos. No existen, entonces, en el derecho colombiano dos categorías de bienes públicos –los bienes de uso público y los bienes fiscales–, sino una pluralidad de categorías de bienes y de afectaciones, cuyo régimen de protección se fundamenta en la necesidad de proteger los intereses generales que dichos bienes permiten cumplir.

  16. Francisco Esperanza de la Fundación Paz y Bien de la ciudad de Cali

    Directory of Open Access Journals (Sweden)

    Juliana Giraldo Orozco

    2006-01-01

    Full Text Available Schutz (1966, citado por Álvarez (2001, desarrolló una teoría acerca de las necesidades interpersonales para identificar tres conductas con las que la gente se relaciona: inclusión, control y afecto. El objetivo de esta investigación es identificar estas tres conductas en un grupo de jóvenes del Programa Casas Francisco Esperanza de la Fundación Paz y Bien de la ciudad de Cali, por medio de la aplicación del FIRO-B y de una entrevista semiestructurada, que indaga estas conductas en los ámbitos de familia, amigos y comunidad. La investigación muestra que en estos ámbitos, los jóvenes priorizan la conducta de inclusión sobre las de control y afecto. Ellos prefieren estar con personas que los acepten, con las cuales puedan interactuar y los hagan sentir pertenecientes y reconocidos

  17. El emprendimiento y el bien común: ¿competencias complementarias o excluyentes?

    Directory of Open Access Journals (Sweden)

    Juan David Enciso-Congote

    2010-04-01

    Full Text Available Este trabajo propone un análisis comparativo entre los requerimientos de la formación de competencias para el emprendimiento y para el desempeño laboral, de acuerdo con el escenario que sirve de contexto a cada una de ellas. En el caso del desempeño laboral, se toma como punto de referencia la estructura burocrática descrita por Max Weber. En cuanto al emprendimiento, las raíces son antropológicas, la naturaleza humana, independientemente de cualquier referente cultural o histórico. Estas consideraciones proporcionan un marco de referencia para reflexionar sobre las dificultades conceptuales y pedagógicas que obstaculizan la construcción de una visión más inclusiva de lo público y del compromiso que debe tener un profesional con la búsqueda del bien común y, por tanto, de la responsabilidad que recae en la formación universitaria para procurar este cometido.

  18. Evolución reciente de la industria argentina de bienes de capital

    Directory of Open Access Journals (Sweden)

    RICARDO ORTIZ

    2013-05-01

    Full Text Available Este artículo busca identificar los principales rasgos del desempeño de la industria argentina de bienes de capital desde una perspectiva de mediano plazo. En particular, se hace eje en los aspectos distintivos de la trayectoria sectorial verificada durante la década de los noventa, cuando estuvo en plena vigencia el modelo neoliberal y se atacó al sector de muy diversas maneras y en la fase de la posconvertibilidad iniciada formalmente a comienzos del año 2002 y que dio lugar a un importante ciclo expansivo de la actividad económica con un rol destacado de la industria manufacturera. Abstract This paper aims to identify the main features of the performance of the argentine industry of capital goods from a medium-term perspective. In particular, the focus is placed upon the distinctive aspects of the sectorial trend verified during the nineties, when the neoliberal model was at its highest validity and the sector was attacked in many different ways and at the stage of “posconvertibilidad” formally initiated in early 2002, which led to a significant expansive cycle of the economic activity with an important role of the manufacturing sector.

  19. De las cenizas a la Red: el Periodismo como bien común

    Directory of Open Access Journals (Sweden)

    José Carlos Sendín Gutiérrez

    2014-11-01

    Full Text Available Sampedro nos ofrece y comparte –porque el libro se puede leer en partes también en la red– no sólo y fundamentalmente un alegato a favor del periodismo, sino además, una defensa de un nuevo poder ciudadano y de una nueva democracia. Desde las primeras líneas el lector se siente sacudido por el alto voltaje de los datos, los personajes y el análisis perspicaz de la transformación social que parece apuntarse, pero que hasta ahora nadie había sabido traducir en palabras. Palabras que a veces parecen querer levantar por las solapas al que lee, como diciendo, “entérate, está pasando ahora y es importante que lo descubras”, mientras desarrolla ideas a las que vuelve y recalca, pasados los capítulos, en un ejercicio circular que pretende dejar clara –y lo consigue– la tesis central: ya existe una nueva forma de periodismo entendido como bien común (sí, al igual que el agua o el aire que respiramos, libre, de código abierto y mancomunado. Aire nuevo para una sociedad desencantada, para un periodismo en busca de modelos y para unas aulas donde se forman los futuros profesionales en una universidad maltratada, pero quizá por ello, también sumida en la conformidad de un saber rutinario.

  20. Sociedad conyugal. partición: adjudicación de bien propio

    Directory of Open Access Journals (Sweden)

    Dora Bagdassarian

    2015-10-01

    Full Text Available El objeto del presente apunta al estudio, de la viabilidad y fundamentalmente a la naturaleza jurídica de la adjudicación de un bien propio de uno de los cónyuges, al otro, en la partición, en la hipótesis de la disolución de la sociedad conyugal. No obstante, para abordar el tema concreto consideramos necesario. algunas breves referendas a determinados aspectos de la sociedad conyugal y concretamente a la partición en general.Contenido: Introducción. Concepto de negocio jurídico. Partición. Ubicación de la partición en la clasificación de los negocios jurídicos. Efecto declarativo retroactivo de la partición. Aplicación del art.1151 C.C. a la partición de la sociedad conyugal. Presupuestos de la partición y de su efecto declarativo. Aplicación de lo expuesto al caso concreto

  1. Evolución de los bienes comunales en el siglo XV

    Directory of Open Access Journals (Sweden)

    José Luis MARTÍN MARTÍN

    2009-12-01

    Full Text Available En las sociedades donde predomina de manera abrumadora la dedicación agropecuaria, las grandes transformaciones de tipo demográfico, social o económico, deben reflejarse de modo claro en la organización del espacio. Parece por eso muy probable que los profundos cambios que se observan durante el siglo XV tengan su incidencia en aquellos elementos productivos más flexibles, que no estaban sujetos a una titularidad personal o familiar, sino en provecho amplio, abierto, de toda la colectividad. Los bienes comunales constituían una especie de reserva de la que ciudades, villas y aldeas disponían según las competencias que tuvieran asumidas, de acuerdo con la tipología y funciones que leyes y costumbres atribuían a cada una de ellas, y según lo permitiera el juego de necesidades y capacidad de decisión que se articulara en cada lugar. Por eso la relación entre ambos tipos de fenómenos no es directa, se desvía hacia otros sectores o aparece con manifestaciones distintas según momentos o zonas.

  2. El Régimen Fiscal de los bienes de la Iglesia durante el siglo IV

    Directory of Open Access Journals (Sweden)

    Narciso Santos Yanguas

    2011-01-01

    Full Text Available El patrimonio de la Iglesia, aunque remonta en sus orígenes a las comunidades cristianas de los 3 primeros siglos, no tendría un reconocimiento oficial hasta la época de Constantino. A continuación lo consolidaría el emperador Constancio II mediante la aplicación de exenciones fiscales. Dicho patrimonio se incrementaría a través de la apropiación de los templos paganos y de sus bienes, a pesar de la fase de regresión que supone la época de Juliano (361-363. A lo largo del siglo IV el Código Teodosiano documenta la situación de las propiedades eclesiásticas y su fiscalidad.The patrimony of the Church, whose origins can be traced back to the Christian communities of the first three centuries, will not officially reckoned until Emperor Constantine’s times. Emperor Constantius II would then consolidate it by applying fiscal exemptions. Despite the fact that Emperor Julian’s rule (361-363 can in itself explain a degree of diminution, the truth is that the said patrimony was increased by the appropriation of pagan temples and the goods contained in them. In the fourth century the Theodosian Codex lists ecclesiastical properties and their fiscal treatment.

  3. Vertical distribution of dioxins in soil of Bien Hoa airbase, Vietnam.

    Science.gov (United States)

    Huyen, Dang Thuong; Igarashi, Toshifumi; Shiraiwa, Takuya

    2015-01-01

    Bien Hoa airbase is a known dioxin-contaminated hotspot in Vietnam. The contamination occurred during the Vietnam War at the site where dioxins were transported, stored, sprayed, and spilled in the area. Dioxins, which are cancer inducing substances, may transfer from the soil to food crops and finally to human beings living around the area. Many surveys of dioxins in soil, water, organisms, and human have been carried out in this study area since 2002. In this paper vertical distribution of dioxins in undisturbed soil cores were examined. Twelve soil samples from three drilled cores were collected to analyze dioxin levels according to the standard Japanese analytical method. The results showed that the toxicity equivalency quantity (TEQ) in one soil sample at a depth of 2.6 m reached 3,300 pg-TEQ/g-dw. High TEQs were also observed in the clay layer. This anomaly of dioxin concentrations could be attributed to the affinity of dioxins for the clay layer. The isomer patterns in the soils were different from those in the soil of Hokkaido in that 2,3,7,8-tetrachlorinated dibenzo-p-dioxin (TCDD) was the most dominant in the soil sample. This indicates that the dioxins originate from a defoliant Agent Orange disposed at the site after the Vietnam War.

  4. Interleukins (ILs), a fascinating family of cytokines. Part II: ILs from IL-20 to IL-38.

    Science.gov (United States)

    Fietta, Pieranna; Costa, Elvira; Delsante, Giovanni

    2015-01-01

    Every nucleated cell can produce and respond to cytokines, extracellular proteic/glycoproteic mediators that constitute a complex, interconnected, and flexible signaling network, addressed to modulate cell behavior and homeostasis through the interaction with high-affinity surface receptors. These messenger molecules, whose main characteristics are potency, pleiotropism, and redundancy, primarily act in autocrine, paracrine, and juxtacrine way, but can also display systemic activity in endocrine-like modality. They are generally classified according to their cellular sources, three-dimensional structure, or biological functions. Among cytokines, interleukins (ILs) represent a fascinating and multifunctional group of immunomodulators that primarily mediate the leukocyte cross-talk (hence the name), and mainly regulate the immune cell proliferation, differentiation, growth, survival, activation, and functions. Up to 38 ILs have been so far identified, numbered according to the order of discovery, and grouped in different subsets, based on distinguishing structural/functional features. Due to their crucial role in regulating inflammation and immune response, ILs are known to be involved in the pathogenesis of human inflammatory/autoimmune diseases. Therefore, they have increasingly attracted great interest as effective or promising therapeutic targets. The biology and functions of the hitherto identified human ILs are reviewed and discussed: herein, ILs from IL-20 to IL-38 are presented.

  5. Interleukins (ILs), a fascinating family of cytokines. Part I: ILs from IL-1 to IL-19.

    Science.gov (United States)

    Fietta, Pieranna; Costa, Elvira; Delsante, Giovanni

    2014-01-01

    Every nucleated cell can produce and respond to cytokines, extracellular proteic/glycoproteic mediators that constitute a complex, interconnected, and flexible signaling network, addressed to modulate cell behavior and homeostasis through the interaction with high-affinity surface receptors. These messenger molecules, whose main characteristics are potency, pleiotropism, and redundancy, primarily act in autocrine, paracrine, and juxtacrine way, but can also display systemic activity in endocrine-like modality. They are generally classified according to their cellular sources, three-dimensional structure, or biological functions. Among cytokines, interleukins (ILs) represent a fascinating and multifunctional group of immunomodulators that primarily mediate the leukocyte cross-talk (hence the name), and mainly regulate the immune cell proliferation, differentiation, growth, survival, activation, and functions. Up to 38 ILs have been so far identified, numbered according to the order of discovery, and grouped in different subsets, based on distinguishing structural/functional features. Due to their crucial role in regulating inflammation and immune response, ILs are known to be involved in the pathogenesis of human inflammatory/autoimmune diseases. Therefore, they have increasingly attracted great interest as effective or promising therapeutic targets. The biology and functions of the hitherto identified human ILs are reviewed and discussed: in this first section of the article, ILs from IL-1 to IL-19 are presented.

  6. Consumo de bienes culturales: reflexiones sobre un concepto y tres categorías para su análisis

    Directory of Open Access Journals (Sweden)

    Luz María Ortega Villa

    2009-01-01

    Full Text Available En este artículo se revisa la elaboración de lo que aquí se denomina consumo de bienes culturales como concepto alternativo al de consumo cultural. El artículo propone a la vez tres categorías de análisis para el objeto de estudio que el primer concepto define.

  7. Le développement durable : est-il possible? est-il mesurable?

    Directory of Open Access Journals (Sweden)

    Belmokaddem MOSTEFA

    2011-04-01

    Full Text Available A la première question, nous répondrons bien sûr, par l’affirmative puisque tous les pays sont engagés dans une nouvelle approche du développement qui ne consiste pas seulement à produire le plus de biens et au moindre coût, afin de vendre beaucoup et réaliser de grands profits. C’était la vision en vigueur dans toutes les techniques de gestion mais on s’est rendu compte que cette production, supposée au moindre coût, était en fait, souvent d’un coût exorbitant, relativement aux dégâts occasionnés dans l’environnement et dans les nuisances occasionnées à la santé de l’homme et à sa tranquillité. Il est temps d’inclure d’autres variables dans le calcul du prix de revient tout en revoyant certaines techniques de production trop salissantes, dangereuses ou grosses consommatrices d’énergie. Nous répondrons aussi par la négative quand on pense qu’au niveau micro économique, les comportements sont édictés par les satisfactions immédiates et les maximisations des profits. Ces comportements qui ne s’intéressent qu’aux résultats à court terme, ne s’intègrent pas facilement dans les plans de développement visant les équilibres macro économiques à long terme.A la deuxième question, nous dirons qu’il y a effectivement des indicateurs pour tester les niveaux de qualité dans l’éducation, la santé, les ressources naturelles... et les gains tirés au niveau social mais les calculs économiques qui déterminent la rentabilité des projets, les profits espérés, les risques financiers encourus ne sont pas toujours en rapport avec les efforts pour réaliser le développement durable qui, eux dépassent la simple notion d’efficacité et de satisfaction. Quand on pense aux générations futures, ce n’est pas seulement en termes de durée dans le temps mais aussi dans la manière d’apprécier les gains espérés.Notre recherche repose sur ces questions qui minent bien des efforts alors qu’il

  8. Un bien pour un mal... des améliorations sanitaires pernicieuses 

    OpenAIRE

    Brisset, Sandrine

    2016-01-01

    Tout projet de développement hydraulique s’accompagne d’importants bouleversements et revivifie la question des maladies hydriques. Il s'agit de comprendre un système eau/santé qui se modifie à mesure qu'il est observé. Nous nous sommes donc placée au cœur de la ville principale de Chennai, la première à restructurer toute son hydraulique urbaine. L'intérêt a été recentré autour de trois maladies traceuses - le choléra O139, la leptospirose humaine, la dengue - et leurs temps d'apparition par...

  9. Strategies targeting the IL-4/IL-13 axes in disease.

    Science.gov (United States)

    May, Richard D; Fung, Michael

    2015-09-01

    IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different cell types and responsible for a broad range of biology and functions. Physiologically, Th2 cytokines are known to mediate host defense against parasites but they can also trigger disease if their activities are dysregulated. In this review we discuss the rationale for targeting the IL-4/IL-13 axes in asthma, atopic dermatitis, allergic rhinitis, COPD, cancer, inflammatory bowel disease, autoimmune disease and fibrotic disease as well as evaluating the associated clinical data derived from blocking IL-4, IL-13 or IL-4 and IL-13 together.

  10. Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update

    National Research Council Canada - National Science Library

    Candel-Martí, Maria-Eugenia; Flichy-Fernández, Antonio-Juan; Alegre-Domingo, Teresa; Ata-Ali, Javier; Peñarrocha-Diago, Maria A

    2011-01-01

    ... (IL-12)) as markers of periimplant disease (mucositis and periimplantitis). An increase in the levels of these cytokines in dental implant crevicular fluid may give rise to a lack of osteointegration, bone loss or implant failure...

  11. Il teatro degli spiriti.

    Directory of Open Access Journals (Sweden)

    Chiara Pussetti

    2013-07-01

    Full Text Available Questo saggio è dedicato a un culto di possessione, in cui tutte ledonne, investite dagli spiriti degli uomini morti prima dell’iniziazione, compiono un percorso iniziatico parallelo a quello maschile, consentendo a queste anime, potenzialmente pericolose, di completare il cammino che non hanno potuto percorrere da vivi e quindi di raggiungere serenamente il mondo dei morti, come antenati protettori del villaggio

  12. Cytokines (interleukin-9, IL-17, IL-22, IL-25 and IL-33 and asthma

    Directory of Open Access Journals (Sweden)

    Rahim Farahani

    2014-01-01

    Full Text Available Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, hyper secretion of mucus, edema and airway hyper responsiveness (AHR, mucus secretion and thickening of the basement membrane underlying the airway epithelium. During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. It was believed that airway inflammation is orchestrated by allergen specific T helper (Th 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD. Interleukin (IL-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor-α and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33 in asthma. The potential therapeutic applications emerging from the roles of these cytokines will be discussed as well.

  13. Marketing Ético como Fundamento del Bien Común en Organizaciones Humanas

    Directory of Open Access Journals (Sweden)

    Alejandro Fernández Baptista

    2014-01-01

    Full Text Available Los hombres poseen necesidades que deben ser satisfechas con el objeto de lograr una vida cónsona con los principios básicos de dignificación de la persona humana, alimento, vestido, medicamentos, comunicación, entretenimiento, transporte, entre otras, son algunas de las necesidades básicas que los seres humanos día tras día se esfuerzan por cubrir mediante el trabajo digno, utilizando para ello las potencialidades propias de cada quien. Las organizaciones modernas por medio del marketing como proceso administrativo, pretende lograr la satisfacción de tales necesidades por medio de la identificación oportuna de dichos requerimientos, elaborando productos y servicios que los satisfagan al crear una propuesta de valor superior a tales expectativas. Sin embargo, tal propuesta debería estar inmersa dentro de parámetros éticos y morales, las cuales garanticen la correcta utilización de cada uno de los elementos de la mezcla de mercadotecnia, producto, precio, promoción y la distribución. De esta manera los gerentes de marketing al momento de tomar decisiones éticas sobre estos tópicos, permitirían en desarrollo de organizaciones humanas promotoras del bien común dentro del contexto donde se desenvuelvanPalabras Clave: Marketing ético; Bien Común; Organizaciones Humanas. Marketing Ethical as the Foundation of the Common Wealth on Human OrganizationsAbstractThe people have needs that must be met for a life in keeping with the basic principles of dignification of the human person, food, clothing, medicines, communication, entertainment, transportation, among others, are some of the basic needs of human beings every day strive to cover using decent, using work of their own potential each person. Modern organizations marketing as administrative process aims at achieving the satisfaction of those needs in the timely identification of those requirements, developing products and services satisfying them to create a proposal for a value

  14. El derecho a comer: Los alimentos como bien público global

    Directory of Open Access Journals (Sweden)

    Ausín, Txetxu

    2010-10-01

    Full Text Available Eating and drinking are essential needs of every human being in every culture and society, and its lack leads to obvious and objective damage. Therefore, food and water becomes moral in terms of universal human right to eat and drink, one of those rights that give and preserve life. However, humanity lives in a grave and intolerable situation of famine, due to structural factors such as international trade and financial policies, production of biofuels, and the abandonment of consumption agriculture, among others. This scenario requires a deep rethinking of public policy on food and drinking water, departing from its conceptualization as public goods, and not as mere commodities.

    Comer y beber son necesidades esenciales de todo ser humano, en toda cultura y sociedad, y su carencia produce, evidentemente, daños graves y objetivos. Por ello, el alimento y el agua potable devienen en exigencias morales universales en términos del derecho humano a comer y a beber, uno de esos derechos que dan y preservan la vida. Sin embargo, la humanidad vive sumida en una gravísima e intolerable situación de hambruna a la que contribuyen algunos factores estructurales como las políticas comerciales y financieras internacionales, la producción de biocombustibles y el abandono de la agricultura de consumo, entre otros. Este panorama obliga a una profunda reformulación de las políticas públicas sobre el alimento y el agua potable, que partan de su conceptualización como bienes públicos y no meras mercancías.

  15. Bienes rústicos de aprovechamiento público en la Valencia moderna

    Directory of Open Access Journals (Sweden)

    David BERNABÉ GIL

    2009-12-01

    Full Text Available RESUMEN: Analiza el presente trabajo diversos aspectos relacionados con los derechos de aprovechamiento público que confluían en los espacios rústicos no cultivados del antiguo Reino de Valencia, así como la naturaleza de los problemas que solía suscitar su atribución dominical, dada la frecuente superposición de instancias institucionales con pretensiones de control. A partir de la compleja tipología que la casuística al respecto —aún escasa y mal conocida— permite entrever, queda en evidencia el fuerte arraigo de los elementos de regulación municipal vigentes en el realengo, si bien en franco retroceso ante los tardíos intentos de control por el Real Patrimonio. En los señoríos, sin embargo, son los derechos del titular de la jurisdicción los que consiguen prevalecer, aunque no necesariamente por exclusión de los reconocidos a la comunidad.ABSTRACT: This study analyzes different aspects related to the rights of public usage with regard to uncultivated agricultural spaces in the ancient Kingdom of Valencia, as well as the nature of the problems normally arising from the conferring of their feudal status, due to the frequent superimposing of institutional requests to gain control. With regard to the complex typology that the corresponding casuistry (still scarce and hardly known suggests, we can highlight the fact that the elements of municipal regulation that existed within the state were well-established, although they were clearly in decline in the face of the Royal Trust's late attempts to gain control. However, as regards the estates, the ownership rights of the jurisdiction were the ones that finally prevailed, although not necessarily by excluding the rights of the community.

  16. Commentary: IL-4 and IL-13 receptors and signaling.

    Science.gov (United States)

    McCormick, Sarah M; Heller, Nicola M

    2015-09-01

    Interleukin (IL)-4 and IL-13 were discovered approximately 30years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.

  17. Il corpo della strega

    Directory of Open Access Journals (Sweden)

    Georges Bertin

    2004-09-01

    Full Text Available Come già evidenziato a proposito di altre pratiche, il sabba, attività ludica profana, religiosa, conferiva a ciascuno la possibilità di giocare efficacemente con la dinamica di un mondo da cui emergeva una figura archetipica, la strega, principale attore di questa danza in tondo. Il sabba era, dunque, uno dei luoghi ove si cristallizzavano le figure del proibito, questo per il suo carattere sacro, per la violenza istituzionale che presiedeva alla formazione dei rapporti sociali, e conferiva anche, per le caratteristiche di protesta che rivela, un'immagine sempre esaltante della capacità delle società a resistere. Il problema della nostra epoca ove rifioriscono le streghe nelle più svariate forme è, forse, quello di riallacciarsi con la dimensione gruppale dei nostri svaghi, nelle loro differenti forme e, contemporaneamente, con perdita di energia, a quanto presiedeva ai sabba e alla loro risoluzione sacrificale. In contro-corrente ai modelli meccanici che assegnano dei limiti precisi e funzionali ai corpi asserviti ad un ideale di controllo, il corpo sabbatico con la sua enfasi sulle posizioni limite (ciò che si rimproverava d'altronde alle streghe, era veramente corpo mistico.

  18. Problemática sobre la disponibilidad de los Bienes Jurídicos Individuales y Responsabilidades Emergentes

    Directory of Open Access Journals (Sweden)

    Ignacio Curbelo Solari

    2013-12-01

    Full Text Available Sobre el concepto de Disponibilidad. Concepto de Bien Jurídico y sus funciones. El Consentimiento. Breve Historia. Bienes Jurídicos Colectivos e Individuales. Naturaleza Jurídica del Consentimiento. Posición de Jescheck, Roxin y Muñoz Conde. Posición de los principales autores nacionales: Prof. Gonzalo Fernández, Miguel Langón, Germán Aller, Pedro Montano. Los requisitos del consentimiento. En la doctrina extranjeraEn la doctrina uruguaya El consentimiento presunto. Requisitos del consentimiento presunto.Relevancia del consentimiento en el Derecho Positivo. Derecho extranjero Derecho Uruguayo. Diversas situaciones. El art. 44 del CP. La Vida. El consentimiento y la responsabilidad de los médicos. Las intervenciones transexuales. La Eutanasia La ley 18.473 de Voluntad anticipada. La auto puesta en peligro.

  19. Problemática sobre la disponibilidad de los Bienes Jurídicos Individuales y Responsabilidades Emergentes

    Directory of Open Access Journals (Sweden)

    Ignacio Curbelo Solari

    2013-12-01

    Full Text Available Sobre el concepto de Disponibilidad. Concepto de Bien Jurídico y sus funciones. El Consentimiento. Breve Historia. Bienes Jurídicos Colectivos e Individuales. Naturaleza Jurídica del Consentimiento. Posición de Jescheck, Roxin y Muñoz Conde. Posición de los principales autores nacionales: Prof. Gonzalo Fernández, Miguel Langón, Germán Aller, Pedro Montano. Los requisitos del consentimiento. En la doctrina extranjeraEn la doctrina uruguaya El consentimiento presunto. Requisitos del consentimiento presunto.Relevancia del consentimiento en el Derecho Positivo. Derecho extranjero Derecho Uruguayo. Diversas situaciones. El art. 44 del CP. La Vida. El consentimiento y la responsabilidad de los médicos. Las intervenciones transexuales. La Eutanasia La ley 18.473 de Voluntad anticipada. La auto puesta en peligro.

  20. EL DILEMA DE LA CONTRIBUCIÓN VOLUNTARIA A BIENES PÚBLICOS: UNA REVISIÓN DE TRABAJOS EXPERIMENTALES

    Directory of Open Access Journals (Sweden)

    Luis Alejandro Palacio García

    2014-01-01

    Full Text Available El artículo presenta una revisión de los experimentos realizados sobre bienes públicos apoyados en el mecanismo de contribución voluntaria. La evidencia empírica existente muestra que los individuos no son solo los seres egoístas y competitivos que supone la teoría económica ortodoxa, sino que también son seres bondadosos y altruistas. Aunque los diversos trabajos experimentales concuerdan en la existencia de estos sentimientos catalogados como "bondad", no es claro si los sujetos actúan así para mejorar el bienestar de los demás (altruismo o porque se sienten bien realizando este tipo acciones (satisfacción moral.

  1. IL web tutorials

    DEFF Research Database (Denmark)

    Hyldegård, Jette; Lund, Haakon

    2012-01-01

    The paper presents the results from a study on information literacy in a higher education (HE) context based on a larger research project evaluating 3 Norwegian IL web tutorials at 6 universities and colleges in Norway. The aim was to evaluate how the 3 web tutorials served students’ information...... seeking and writing process in an study context and to identify barriers to the employment and use of the IL web tutorials, hence to the underlying information literacy intentions by the developer. Both qualitative and quantitative methods were employed. A clear mismatch was found between intention...... and use of the web tutorials. In addition, usability only played a minor role compared to relevance. It is concluded that the positive expectations of the IL web tutorials tend to be overrated by the developers. Suggestions for further research are presented....

  2. Il cervello Empatico

    Directory of Open Access Journals (Sweden)

    Alessandro Baffigi

    2012-04-01

    Full Text Available Empatia (gr. En –dentro- Pathos – emozione è un termine che rispecchia una facoltà che nasce, probabilmente, con la nascita stessa dell’uomo. La derivazione del termine empatia è fatta risalire a “empatheia” (passione, la possibilità dell’ “ingresso nella sofferenza” dell’altro fino all’immedesimazione. Originariamente, il termine empatia definisce il rapporto dell’Aedo con il suo pubblico, nei termini del coinvolgimento che porta ad una consonanza emotiva dei vissuti. Sta scritto nell’Odissea, mentre Ulisse racconta le sue disavventure: “Così narrava e tutti rimasero muti, in silenzio / vinti dal fascino nella sala ombrosa”(Od. XI, 333-4.

  3. Environmental Health Risk Assessment of Dioxin Exposure through Foods in a Dioxin Hot Spot—Bien Hoa City, Vietnam

    OpenAIRE

    Tran Thi Tuyet-Hanh; Le Vu-Anh; Nguyen Ngoc-Bich; Thomas Tenkate

    2010-01-01

    This study used the Australian Environmental Health Risk Assessment Framework to assess the human health risk of dioxin exposure through foods for local residents in two wards of Bien Hoa City, Vietnam. These wards are known hot-spots for dioxin and a range of stakeholders from central government to local levels were involved in this process. Publications on dioxin characteristics and toxicity were reviewed and dioxin concentrations in local soil, mud, foods, milk and blood samples were used ...

  4. Análisis de los criterios de intervención en Bienes Eclesiásticos

    Directory of Open Access Journals (Sweden)

    María José González López

    2015-06-01

    Full Text Available En este artículo se analizan los criterios con los que se debe abordar la intervención en bienes culturales de procedencia eclesiástica en nuestro país a partir del análisis de los apartados específicos de la normativa dictada por el Estado Español y por la Santa Sede, así como en la concordada mediante acuerdos y convenios suscritos entre ambos.

  5. Dostoevskij e il sillogismo

    Directory of Open Access Journals (Sweden)

    Richard Peace

    2013-12-01

    Full Text Available Si presenta di seguito la prima traduzione italiana del saggio di Richard Peace Dostoevsky and the Syllogism, pubblicato in lingua originale nel volume IX (2005 della collana Dostoevsky Studies, New Series. Il saggio è dedicato alla rielaborazione del sillogismo aristotelico da parte dei personaggi dostoevskiani nell’ambito del dibattito fra le due principali correnti filosofiche della Russia ottocentesca: l’ «occidentalismo» e lo «slavofilismo». Peace evidenzia come Dostoevskij miri a dimostrare che il ragionamento sillogistico sia estraneo alla forma mentis russa attraverso i fallimenti argomentativi dei suoi «ideofori»

  6. IL web tutorials

    DEFF Research Database (Denmark)

    Hyldegård, Jette; Lund, Haakon

    2012-01-01

    The paper presents the results from a study on information literacy in a higher education (HE) context based on a larger research project evaluating 3 Norwegian IL web tutorials at 6 universities and colleges in Norway. The aim was to evaluate how the 3 web tutorials served students’ information...... seeking and writing process in an study context and to identify barriers to the employment and use of the IL web tutorials, hence to the underlying information literacy intentions by the developer. Both qualitative and quantitative methods were employed. A clear mismatch was found between intention...

  7. Predictors for dioxin accumulation in residents living in Da Nang and Bien Hoa, Vietnam, many years after Agent Orange use.

    Science.gov (United States)

    Pham, Diem T; Nguyen, Hang M; Boivin, Thomas G; Zajacova, Anna; Huzurbazar, Snehalata V; Bergman, Harold L

    2015-01-01

    Agent Orange (AO) was the main defoliant used by the US in Vietnam from 1961 to 1971; AO was contaminated with dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, or TCDD). Three major dioxin “hot spots” remain from previous AO storage and use at former US bases at Bien Hoa, Da Nang, and Phu Cat, posing potential health risks for Vietnamese living on or near these hot spots. We evaluated potential risk factors contributing to serum TCDD levels in Vietnamese residents at and near contaminated sites in Da Nang and Bien Hoa, Vietnam. We used multiple linear regression to analyze possible associations of blood dioxin concentrations with demographic, socioeconomic, lifestyle, and dietary risk factors for residents living on or near these hot spots. For the Da Nang study, fish farming on the site, living on property flooded from monsoon rains, and age were among the factors showing significant positive associations with serum TCDD concentrations. For the Bien Hoa study, fish farmers working at this site and their immediate family members had significantly higher serum TCDD concentrations. Our results suggest that water-related activities, especially fish-farming, at the hot spots increased the risk of exposure to dioxin.

  8. Ética de la convivencia en organizaciones del presente: Base fundamental para alcanzar el bien común

    Directory of Open Access Journals (Sweden)

    Cristina Seijo

    2014-01-01

    Full Text Available El propósito de esta investigación es establecer algunas consideraciones teóricas sobre la ética de la convivencia en las organizaciones de presente, de manera que la gerencia en estas organizaciones se perfile hacia la búsqueda del bien común, en este sentido, el estudio se basa en una metodología cualitativa, de tipo descriptiva y diseño no experimental, mediante un análisis documental, ubicada dentro del área de las Ciencias Sociales.En este sentido, el logro del bien común está asociado a alcanzar una vida en convivencia, esto significa lograr acuerdos mínimos a través del diálogo entre los ciudadanos de manera que se pueda establecer el respeto hacia el otro. La base de tales acuerdos será, necesariamente, la búsqueda del bienestar de la sociedad, es decir, el bien común. Esta idea justifica la necesidad de una ética común, la que conlleva al reconocimiento del otro, aceptar el bienestar del otro, aceptación del otro en nuestro sistema, para lograr la convivencia y alcanzar el bienestar o bien común.Palabras Clave: Ética de la convivencia; bien común; acuerdos mínimos. Ethics of the Living together in organizations of future: fundamental Base to reach the common goodAbstractThis research aims at advancing concepts regarding fellowship ethics in contemporary organizations, in order to organize management around common good practices. The achievement of the common good is thus associated to reaching fellowship, this is to achieve minimal consensus through dialog between citizens and strengthen respect to each other. The base of such consensus will be, necessarily, societal welfare, that is to say, the common good.Keywords: Ethics of the living; common good; minimal agreements.

  9. Il pericolo degli ebook

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2014-01-01

    Full Text Available I libri stampati: si possono acquistare anonimamente in contanti; quindi se ne è proprietari: non dobbiamo firmare una licenza che ne restringe l’uso: il loro formato è noto e per leggerli non occorrono tecnologie proprietarie; si possono dare, prestare o...

  10. Il Carmide di Platone

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2014-03-01

    Full Text Available L’ipertesto dedicata al Carmide di Platone, composto per l’uso degli studenti dell’ateneo pisano, è a disposizione di tutti qui. Il Carmide è – canonicamente – un dialogo aporetico. Ma almeno dei suoi paradossi – quello di una superscienza che pretende...

  11. Il dono del racconto

    DEFF Research Database (Denmark)

    Polito, Paola

    1998-01-01

    'importanza assunta nel romanzo dal piano dell'enunciazione come luogo privilegiato di manifestazione del soggetto quale esperiente una vicenda di maturazione. Il protagonista, qui, non solo si rappresenta in ciò che enuncia e riferisce, ma anche e soprattutto si svela nelle modalità specifiche del proprio discorso...

  12. Helping You Buy ILS

    Science.gov (United States)

    Cibbarelli, Pamela R.

    2010-01-01

    This article is the fourth in a series of articles published annually by "Computers in Libraries" surveying integrated library systems and services (ILSs). The purpose of the annual survey is to enable comparison of the ILSs that are available. ILS vendors are in constant pursuit of an ever-changing, consistently vague definition of what the…

  13. Oltre il postmoderno?

    DEFF Research Database (Denmark)

    Cecchini, Leonardo

    2014-01-01

    literature ’do’ today to call itself engaged? In the first part of this paper, I try to give a short description of the way in which the radical mutations in the field of culture at the end of the last century were discussed in Italy, outlining in particular Oltre il postmoderno? the debate between...

  14. Il Simposio di Platone

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2013-01-01

    Full Text Available Pensate che i testi antichi siano semplicemente vecchi? Che l’amore platonico non vada mai  al sodo? Leggere il Simposio di Platone confrontandosi direttamente col testo, com’è possibile fare grazie al Perseus Project, vi farà cambiare idea.

  15. Il diabete che migra

    Directory of Open Access Journals (Sweden)

    Angela Infante

    2009-04-01

    Full Text Available Nel gennaio 2007 ha avuto inizio il “Corso di Counseling e Terapie Interculturali”; nello stesso gennaio il Servizio di Diabetologia Pediatrica dell’Azienda Universitaria Ospedaliera Policlinico Tor Vergata di Roma ha richiesto la mia collaborazione per un progetto relativo all’alleanza e all’aderenza terapeutica del minore straniero affetto da diabete mellito. Ho avuto l’opportunità di partecipare a questo progetto, poiché avevo avuto precedenti esperienze nel Servizio di Medicina Solidale e delle Migrazioni, progetto del medesimo Policlinico. Questo progetto riguarda tutti i minori autoctoni e migranti affetti dalla suddetta patologia, in cura presso l’Unità Operativa di Diabetologia Pediatrica. Il mio ruolo principale all’interno del progetto è quello di apportare un doppio ascolto medico-counselor durante le visite di controllo, che possono variare a seconda dell’andamento della patologia, da una cadenza mensile ad una quindicinale. Durante questi colloqui il mio primo intento è quello di approcciarmi alla famiglia in un’ottica sistemica, in seguito di affrontare una ricostruzione autobiografica della storia familiare e del processo migratorio.

  16. Il Raffrescamento per Ventilazione

    DEFF Research Database (Denmark)

    Perino, Marco; Heiselberg, Per Kvols

    2016-01-01

    termicamente e sempre più a tenuta d'aria. Tali misure hanno consentito indubbiamente di ridurre la domanda energetica per il riscaldamento invernale, ma hanno determinato delle crescenti problematiche di surriscaldamento dell'ambiente interno. Molti degli edifici ad alta efficienza energeti-ca di nuova...

  17. Il Fedone di Platone

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2015-01-01

    Full Text Available Nei colloqui precedenti si erano toccate molte opinioni filosofiche sbagliate, e allora Socrate dice: “Sarebbe ben comprensibile se uno, a motivo dell’irritazione per tante cose sbagliate, per il resto della sua vita prendesse in odio ogni discorso sull’essere e lo...

  18. Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27

    Directory of Open Access Journals (Sweden)

    Mingli Xu

    2010-01-01

    Full Text Available The interleukin (IL-12 family, which is composed of heterodimeric cytokines including IL-12, IL-23, and IL-27, is produced by antigen-presenting cells such as macrophages and dendritic cells and plays critical roles in the regulation of helper T (Th cell differentiation. IL-12 induces IFN- production by NK and T cells and differentiation to Th1 cells. IL-23 induces IL-17 production by memory T cells and expands and maintains inflammatory Th17 cells. IL-27 induces the early Th1 differentiation and generation of IL-10-producing regulatory T cells. In addition, these cytokines induce distinct immune responses to tumors. IL-12 activates signal transducers and activator of transcription (STAT4 and enhances antitumor cellular immunity through interferon (IFN- production. IL-27 activates STAT1, as does IFN- and STAT3 as well, and enhances antitumor immunity by augmenting cellular and humoral immunities. In contrast, although exogenously overexpressed IL-23 enhances antitumor immunity via memory T cells, endogenous IL-23 promotes protumor immunity through STAT3 activation by inducing inflammatory responses including IL-17 production.

  19. Economía, bienes públicos puros e Internet : revelando el caso del FLOSS (“Free/Libre Open Source Software” o “Software Libre y Software de Código Abierto”)

    OpenAIRE

    Soler Muñoz, Rafael

    2013-01-01

    Desde que Paul Samuelson publicase en 1954 su obra “The pure theory of public expenditure”, diferenciando los bienes económicos entre bienes públicos y bienes privados, ha existido controversia sobre la posibilidad de que los bienes públicos pudiesen encontrarse en estado "puro". En nuestra tesis exponemos, con el ejemplo del FLOSS (Free/Libre Open Source Software), como la existencia de bienes públicos puros tendría lugar cuando bienes digitales son distribuidos a través de redes "peer to pe...

  20. Data on interleukin (IL)-2- and IL-15-dependent changes in IL-2Rβ and IL-2Rγ complexes

    DEFF Research Database (Denmark)

    Osinalde, Nerea; Sánchez-Quiles, Virginia; Blagoev, Blagoy

    2017-01-01

    We provide detailed datasets from our analysis of the proteins that associate with IL-2Rβ and IL-2Rγ in T-cells stimulated with IL-2 or IL-15 compared with resting T-cells, as identified by SILAC-based quantitative proteomics. We also include quantitative data regarding site-specific phosphorylat...... "Characterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes" (Osinalde et al., 2016 [1]). The mass spectrometry data have been deposited to the ProteomeEXchange Constorium with the identifier PXD002386....

  1. IL-4 and IL-13 signaling in allergic airway disease.

    Science.gov (United States)

    Gour, Naina; Wills-Karp, Marsha

    2015-09-01

    Aberrant production of the prototypical type 2 cytokines, interleukin (IL)-4 and IL-13 has long been associated with the pathogenesis of allergic disorders. Despite tremendous scientific inquiry, the similarities in their structure, and receptor usage have made it difficult to ascertain the distinct role that these two look-alike cytokines play in the onset and perpetuation of allergic inflammation. However, recent discoveries of differences in receptor distribution, utilization/assembly and affinity between IL-4 and IL-13, along with the discovery of unique innate lymphoid 2 cells (ILC2) which preferentially produce IL-13, not IL-4, are beginning to shed light on these mysteries. The purpose of this chapter is to review our current understanding of the distinct roles that IL-4 and IL-13 play in allergic inflammatory states and the utility of their modulation as potential therapeutic strategies for the treatment of allergic disorders.

  2. Il nucleo terrestre: il cuore magnetico della Terra

    OpenAIRE

    De Santis, A.

    2006-01-01

    Il campo magnetico terrestre è una proprietà intrinseca del nostro pianeta e di altri oggetti del sistema solare. Il Sole stesso possiede un forte campo magnetico che si inverte quasi ciclicamente ogni 10-11 anni; tale comportamento è visibile attraverso la medesima ciclicità delle macchie solari che denotano sulla superficie l’intensa attività magnetica della nostra stella. Il campo magnetico terrestre è importantissimo per la vita sulla Terra. Esso protegge il pianeta dalle p...

  3. Il cattivo psicoanalista

    Directory of Open Access Journals (Sweden)

    Massimiliano Tosolini

    2015-12-01

    Full Text Available Il cattivo psicoanalista dunque, in genere, rischia di essere colui che si isola, che pratica poco e che, quando pratica, crede di poter operare al di là delle conoscenze e delle altre esperienze dei colleghi. Per tale ragione è necessario che la comunità degli psicoanalisti sia ancora più unita, oltre che per continuare ad esistere come psicoanalisti, anche, e soprattutto, per esistere come buoni psicoanalisti. Uno dei compiti del Coopi (Coordinamento Psicoanalisti Italiani è anche questo, oltre alla divulgazione della psicoanalisi mantenendone viva l'esistenza, il Coopi ha tra i suoi fondamenti quello di dare l'opportunità a tutti gli analisti di esercitare la buona pratica tramite lo scambio culturale e umano che solo attraverso gli incontri nelle reciproche differenze è possibile realizzare.

  4. Il libro di fisica

    CERN Document Server

    Asimov, Isaac

    1986-01-01

    Isaac Asimov, illustre studioso e brillante divulgatore scientifico, ma anche grandissimo scrittore di science fiction, ha costruito questa volta una vera e propria «biografia delle scienze fisiche». Il presente volume, che nel mondo anglosassone è diventato una «bibbia della fisica», ci introduce, in forma semplice ma rigorosa, ai segreti dei quasar e dei buchi neri, dei quark e degli acceleratori di particelle, dell'intelligenza artificiale e delle fonti di energia, sia essa quella «sporca» sia quella «pulita». Un vero, completo manuale, ma anche un «romanzo» affascinante sia per il profano sia per l'uomo di scienza.

  5. Il cervello Cosciente

    Directory of Open Access Journals (Sweden)

    Marcello Massimini

    2012-04-01

    Full Text Available Si può definire la coscienza come tutto ciò che scompare quando cadiamo addormentati in un sonno senza sogni, oppure come tutto ciò che scompare quando siamo sottoposti ad anestesia generale. Questa definizione, basata sulla nostra esperienza soggettiva, è generale, ampiamente condivisa, ma chiaramente pre-scientifica. Una definizione scientifica di coscienza presuppone che si affronti (e che si risolva il problema cervello-coscienza. In sostanza, risolvere questo problema significa rispondere alla seguente domanda: “come fa un pugno di neuroni racchiuso nel cranio ad ospitare un soggetto che vede rosso?”. I filosofi chiamano questo problema “the hard problem” (il problema difficile e molti ritengono che non sia affrontabile scientificamente; assumendo una posizione ancora più radicale, alcuni filosofi negano che vi sia un rapporto causale tra l’attività del cervello e la nostra esperienza soggettiva.

  6. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans

    DEFF Research Database (Denmark)

    Steensberg, Adam; Fischer, Christian Philip; Keller, Charlotte

    2003-01-01

    The purpose of the present study was to test the hypothesis that a transient increase in plasma IL-6 induces an anti-inflammatory environment in humans. Therefore, young healthy volunteers received a low dose of recombinant human (rh)IL-6 or saline for 3 h. Plasma IL-6 levels during rhIL-6 infusion...... number without effects on plasma epinephrine, body temperature, mean arterial pressure, or heart rate. In conclusion, this study demonstrates that physiological concentrations of IL-6 induce an anti-inflammatory rather than an inflammatory response in humans and that IL-6, independently of TNF......-induced leukocyte trafficking....

  7. Il crepuscolo delle idee

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2011-08-01

    Full Text Available Segnalo questo dibattito non perché sia originale, ma perché non lo è per nulla: il suo tema è infatti quello, famosissimo, della critica alla scrittura contenuta nel mito platonico di Theuth, anche se non sempre chi discute ne è consapevole. Secondo Neal Gabler (* stiamo attualmente vivendo in un’età post-illuministica e “post-ideale”. Internet offre l’accesso [...

  8. Il cattivo psicoanalista

    OpenAIRE

    Massimiliano Tosolini

    2015-01-01

    Il cattivo psicoanalista dunque, in genere, rischia di essere colui che si isola, che pratica poco e che, quando pratica, crede di poter operare al di là delle conoscenze e delle altre esperienze dei colleghi. Per tale ragione è necessario che la comunità degli psicoanalisti sia ancora più unita, oltre che per continuare ad esistere come psicoanalisti, anche, e soprattutto, per esistere come buoni psicoanalisti. Uno dei compiti del Coopi (Coordinamento Psicoanalisti Italiani) è anche questo, ...

  9. Il progetto Linked Heritage

    Directory of Open Access Journals (Sweden)

    Marzia Piccininno

    2013-03-01

    Full Text Available ItLinked Heritage è uno dei progetti di punta finanziati dalla Commissione europea per alimentare Europeana, il portale dei contenuti culturali digitali europei. Linked Heritage raccoglie, sotto il coordinamento dell’ICCU, un consorzio molto vasto i cui partner provengono da quasi tutti i paesi dell’Unione più Russia e Israele; essi forniranno a Europeana ben 3 milioni di risorse digitali. Oltre al tema dell’aggregazione di contenuti culturali digitali, Linked Heritage sta esplorando altri temi fondamentali per Europeana come il multilinguismo, i linked data e il rapporto con possibili partner commerciali. Linked Heritage è l’ultimo in ordine di tempo di una serie di iniziative progettuali avviate da un consorzio europeo di istituzioni che opera insieme da oltre dieci anni nell’ambito del patrimonio culturale digitale.EnLinked Heritage is one of the flagship projects funded by the European commission to feed Europeana, the portal of the European digital cultural content. Linked Heritage has a very large partnership, coordinated by ICCU, whose members come from many European countries, Russia and Israel; they will supply Europeana with 3 million digital resources. Beyond the aggregation of digital cultural content, Linked Heritage is exploring other topics which are essential for Europeana, like multilingualism, linked data and the relationship with the commercial partners. Linked Heritage is the last one in time of a series of projects made up by a European consortium of institutions that has been working for over ten years in the field of digital cultural heritage.

  10. Assessment of the Effects of IL9, IL9R, IL17A, and IL17F Gene ...

    African Journals Online (AJOL)

    Effects of IL genes Polymorphisms on women with Allergic Rhinitis. Annals of Medical ... be engaged.[3,4]. The interleukin-9 receptor gene (IL9R), belonging to the hematopoietin ..... Asthma and bronchial hyperresponsiveness linked to the XY ...

  11. El añil en la Venezuela ilustrada.

    Directory of Open Access Journals (Sweden)

    Frédérique Langue

    2005-02-01

    Full Text Available En el mundo hispánico pasó a la posteridad el añil, o mejor dicho la planta conocida bajo el nombre deindigoferea tintorea , con motivo del tinte azul que se solía extraer de esta planta. Bastante bien conocida y difundida en Nueva España donde los colorantes fueron objeto de activo comercio desde la época prehispánica, el “pastel” o xiquilite continuó su expansión por América Central a lo largo del siglo XVII, y sobre todo, en el siglo XVIII. Guatemala se convirtió entonces en el centro de l...

  12. Il Cinema ritrovato Bologne, 2-9 juillet 2005

    OpenAIRE

    Pithon, Rémy; Leonardi, Francesca; Gili, Jean Antoine; Jaques, Pierre-Emmanuel

    2014-01-01

    Le traditionnel rendez-vous estival organisé par la dévouée équipe de la Cineteca di Bologna proposait cette année aux chercheurs qui le fréquentent assidûment un menu aussi varié et aussi passionnant que d’habitude, même s’il comportait peu de découvertes majeures. Selon des traditions désormais bien ancrées, figurait au programme toute une série de sections parallèles : le « projet Chaplin », des productions qui « mettent en scène » la guerre, l’ensemble intitulé « Cento anni fa : i film de...

  13. Retos para la política ambiental: el debate internacional sobre el comercio de bienes y servicios ambientales

    Directory of Open Access Journals (Sweden)

    Diego Alejandro Martínez Ballesteros

    2006-01-01

    Full Text Available Los lineamientos de la actual política ambiental nacional enfatizan la promoción y el aprovechamiento sostenible de bienes y servicios ambientales. A nivel internacional, el tema se está tratando en la Organización Mundial del Comercio, por el mandato de la Declaración Ministerial de Doha (2001. Así mismo, se encuentra tácitamente en la actual agenda del desarrollo. El debate ha girado alrededor de lograr un acuerdo sobre definiciones y criterios de bienes y servicios ambientales para el comercio. Se ha mantenido una visión restringida sobre estos ítems, que excluye apreciaciones integrales desde la economía ambiental. Los bienes y servicios relacionados con la biodiversidad y los que proporcionan los ecosistemas, que podrían interesar a los países ‘megadiversos’ como Colombia no ocupan el centro del debate. La ausencia y la pasividad en este debate pueden conllevar a la pérdida de beneficios y oportunidades de la utilización sostenible de los recursos naturales, en contravía con la intención de la actual política ambiental. Así mismo, los resultados que se logren en la OMC tendrán repercusiones en otros tratados comerciales bilaterales o regionales que celebre el país y en el nivel de autonomía sobre el control de recursos naturales estratégicos

  14. Retos para la política ambiental: el debate internacional sobre el comercio de bienes y servicios ambientales

    Directory of Open Access Journals (Sweden)

    Diego Alejandro Martínez Ballesteros

    2006-11-01

    Full Text Available Los lineamientos de la actual política ambiental nacional enfatizan la promoción y el aprovechamiento sostenible de bienes y servicios ambientales. A nivel internacional, el tema se está tratando en la Organización Mundial del Comercio, por el mandato de la Declaración Ministerial de Doha (2001. Así mismo, se encuentra tácitamente en la actual agenda del desarrollo. El debate ha girado alrededor de lograr un acuerdo sobre definiciones y criterios de bienes y servicios ambientales para el comercio. Se ha mantenido una visión restringida sobre estos ítems, que excluye apreciaciones integrales desde la economía ambiental. Los bienes y servicios relacionados con la biodiversidad y los que proporcionan los ecosistemas, que podrían interesar a los países ‘megadiversos’ como Colombia no ocupan el centro del debate. La ausencia y la pasividad en este debate pueden conllevar a la pérdida de beneficios y oportunidades de la utilización sostenible de los recursos naturales, en contravía con la intención de la actual política ambiental. Así mismo, los resultados que se logren en la OMC tendrán repercusiones en otros tratados comerciales bilaterales o regionales que celebre el país y en el nivel de autonomía sobre el control de recursos naturales estratégicos.

  15. Observaciones sobre la opinión pública a partir de "El ciudadano bien informado"

    OpenAIRE

    Juárez, Benjamín

    2008-01-01

    Alfred Schutz se pregunta hasta qué punto tienen y pueden llegar las responsabilidades civiles. Antes de eso se pregunta por las preocupaciones e intereses del ciudadano y la importancia del pensamiento razonable anclado en la individualidad y en contraposición a la opinión desinformada de la masa. En este escrito se busca no tanto ni solamente responder a la inquietud de Schutz, sino darle historia y significado al problema que presenta. Se enuncia lo que se entiende por ciudadano bien infor...

  16. Evaluación del aprendizaje de adolescentes del proyecto Bebé Piénsalo Bien (BPB)

    OpenAIRE

    Velandía Pedraza, Ángela Lucía

    2013-01-01

    El presente documento es un estudio mixto con predominio cualitativo, cuyo objetivo es determinar los aspectos fundamentales del aprendizaje significativo presentes para el abordaje de los temas de maternidad y paternidad responsable en los grupos de adolescentes que participaron en el proyecto de Bebé Piénsalo Bien (BPB) en el colegio Técnico Internacional. Como instrumento se aplicó individualmente la misma encuesta que se aplicó a los adolescentes que participaron en el proyecto bebé piéns...

  17. El bien jurídico protegido en los delitos urbanísticos. Una propuesta de lege ferenda

    OpenAIRE

    Martín Pardo, Antonio

    2015-01-01

    El presente trabajo de investigación tiene por objeto el intento de realizar una propuesta convincente de bien jurídico protegido en el ámbito de los delitos urbanísticos. Dicha propuesta se realiza, como señala el título, desde una perspectiva de lege ferenda y, por tanto, desligada en un principio del concreto tenor literal de los tipos existentes en el Código penal. En el ámbito que nos ocupa, el de la ordenación territorial y el urbanismo hace ya veinte años que existen estos delitos ...

  18. Evaluación del aprendizaje de adolescentes del proyecto Bebé Piénsalo Bien (BPB)

    OpenAIRE

    Velandía Pedraza, Ángela Lucía

    2013-01-01

    El presente documento es un estudio mixto con predominio cualitativo, cuyo objetivo es determinar los aspectos fundamentales del aprendizaje significativo presentes para el abordaje de los temas de maternidad y paternidad responsable en los grupos de adolescentes que participaron en el proyecto de Bebé Piénsalo Bien (BPB) en el colegio Técnico Internacional. Como instrumento se aplicó individualmente la misma encuesta que se aplicó a los adolescentes que participaron en el proyecto bebé piéns...

  19. Bienes públicos regionales para la fortificación de alimentos con micronutrientes en Centroamérica

    OpenAIRE

    Isabel Nieves; Nicté Ramírez; Alexa N. Monroy

    2012-01-01

    El proyecto de bienes públicos regionales (BPR) en fortificación masiva de alimentos de alto consumo que el BID co-financió en el 2007 para el conjunto de los siete países de la región, se diseñó bajo la premisa que a través de la cooperación transnacional se pueden potenciar los avances en el control de las deficiencias de micronutrientes prevalentes que, hasta entonces, se abordaban mayormente de manera individual.

  20. La Protección Jurídica de los Bienes Culturales en el Derecho Español

    Directory of Open Access Journals (Sweden)

    Luis A. Anguita Villanueva

    2004-01-01

    Full Text Available RESUMEN El presente artículo trata de la protección de los bienes que manifiestan elementos o valores de la cultura española. Se define, primero, el concepto y el contenido normativo de los bienes culturales a la luz del derecho positivo, tanto nacional español como supranacional. Se revisan, luego, los antecedentes históricos de la protección de los bienes culturales en el Derecho español, para luego examinar el marco jurídico actual del patrimonio histórico, tanto desde la perspectiva de la normativa supranacional (UNESCO, el Consejo de Europa, la Unión Europea y el Convenio de UNIDROIT, como de la normativa nacional, expresada en la Constitución, el ordenamiento estatal y los ordenamientos autonómicos. El trabajo pone de relieve que la complejidad de la protección de los bienes culturales deriva, en parte, de la dificultad de definir o delimitar el concepto de cultura en la ciencia del Derecho y, por otro lado, de la división político-competencial que se diseña en España a través de la Constitución de 1978, que ha dado pie a una hipertrofia normativa, común a los países de modelo "federal" de distribución de competencias, que dificulta la aplicación por parte de los operadores jurídicos.ABSTRACT The article examines the status of objects which embody elements or values of the Spanish culture. First, the legal notion of cultural objects is defined, considering national and supranational law. We then review the historical background of the protection of cultural objects in Spanish law, turning next to the current legal framework for the protection of the historical patrimony, both from a supranational normative perspective (UNESCO, the Council of Europe, The European Union, and the UNIDROIT agreement, and the Spanish national law found in the Constitution, the national law, and the law of the autonomous regions. Throughout the article the notion is stressed that the complexity we find in the protection of cultural

  1. Aristocracia local y trasvases de bienes en Liébana (siglo XIII. Revisión del problema

    Directory of Open Access Journals (Sweden)

    Rosana Vassallo

    2013-03-01

    Full Text Available El presente trabajo analiza los trasvases de bienes entre aristocracias locales y monasterios. Las donaciones pro anima, realizadas por los sectores destacados de la sociedad, quedaron vinculadas tradicionalmente a las necesidades espirituales de la aristocracia, reduciendo la actuación patrimonial del sector en un sentido unidireccional. El presente estudio pretende reubicar dichos trasvases en un juego más amplio de transacciones mutuas que sólo pueden ser entendidas apelando a las estrategias de reproducción social de los sujetos actuantes

  2. Perspectivas sobre la gobernanza de los bienes y la ciudadanía en la obra de Elinor Ostrom

    OpenAIRE

    Leticia Merino Pérez

    2014-01-01

    Este trabajo reflexiona sobre las principales aportaciones conceptuales y me - todológicas de la obra de Elinor Ostrom, con - siderando el contexto conceptual y político en que emergió y se desarrolló: la polémica con las hegemónicas tesis de Garret Hardin sobre la tragedia de los bienes comunes y la teo - ría de la elección racional. Analiza las ruptu - ras y continuidades de la obra de Ostrom en relación con distintos paradigmas dominantes en las ciencias sociales. Indica también que sus ap...

  3. IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes

    Directory of Open Access Journals (Sweden)

    Hisako Hayashi

    2014-01-01

    Full Text Available Interleukin-33 appears to play important roles in the induction of allergic airway inflammation. However, whether IL-33 is involved in airway remodeling remains unclear. Because fibrocytes contribute to tissue remodeling in the setting of chronic inflammation, we examined the effects of IL-33 on fibrocyte functions. Fibrocytes were generated in vitro from peripheral blood mononuclear cells by culturing in the presence of platelet derived growth factors and the cells were stimulated with IL-33. IL-33 enhanced cell proliferation, α-SMA expression, and pro-MMP-9 activity by the fibrocytes without increasing endogenous transforming growth factor-β1 production. Fibrocytes constitutively expressed IL-13 and IL-5, and their production was augmented by stimulation with IL-33. Dexamethasone inhibited the functions of fibrocytes, but IL-33 made fibrocytes slightly refractory to the inhibitory effect of dexamethasone in terms of IL-13 production. Montelukast suppressed IL-13 production by nonstimulated fibrocytes but not those stimulated by IL-33. These findings suggest that IL-33 is involved in the airway remodeling process through its modulation of fibrocyte function independent of antigen stimulation. IL-33 might partially reduce the therapeutic effects of glucocorticoid and cysteinyl leukotriene receptor antagonist on fibrocyte-mediated Th2 responses.

  4. Il ricordo di Bernardo

    Directory of Open Access Journals (Sweden)

    Vincenzo Caporale

    2004-01-01

    Full Text Available Capita, nella vita, di incontrare il dolore perun amico che ci lascia, per un collaboratoreprezioso che non c’è più, per un professionistadi livello che se ne va e scava un vuoto, un buco,che poi non si colma.Ecco, questo è successo a noi dell’IstitutoZooprofilattico Sperimentale dell’Abruzzo e delMolise quando Bernardo Di Emidio, il 23gennaio, è mancato. Abbiamo incontrato undolore grande (e mi perdonerete se parlo delmio, io personalmente in quel dolore sonoinciampato con violenza, perché l’amico DiEmidio aveva condiviso in tutto il tempo in cuiabbiamo lavorato insieme, ogni preoccupazione,tensione, soddisfazione e progettualità.Difficile, per me, è stato ricordarlo proprio ilgiorno dopo la sua morte, in apertura di unconvegno, con la platea piena della gentedell’Istituto e ognuno con gli occhi rossi, losgomento e la solitudine già forte della perditascolpita sul volto. L’abbiamo salutato lì, gli hodetto grazie e ciao da parte di tutti gli altri, manon l’abbiamo mai salutato davvero.Non l’ha ancora fatto nessuno di noi, echissà se lo faremo mai, perché da Bernardonon vogliamo separarci.Sulle pagine di questa rivista, che rendonomerito e onore a tanti ottimi professionisti,proprio su una rivista scientifica, che per ilnostro ambiente è il momento del confronto,spesso «della verità», voglio ricordareBernardo Di Emidio.Voglio ricordarlo all’intera comunitàscientifica per quel grande lavoratore che èstato, per quella piena fiducia che i suoicollaboratori gli davano, per quel bellissimo rapporto che con loro aveva saputo costruire,ricominciando ad ogni nuovo arrivo. Loro, isuoi collaboratori, l’hanno sostenuto fino allafine, hanno continuato a considerarlo il lorocapo, anche durante i momenti più brutti edurante gli ultimi.Non hanno mai fatto a meno del suoparere, della sua approvazione, non si sono allontanati, non si allontano nemmeno oggi, da quel solco di umanità e scientificità che Di Emidio, in anni e

  5. Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs.

    Science.gov (United States)

    Kunz, Stefanie; Wolk, Kerstin; Witte, Ellen; Witte, Katrin; Doecke, Wolf-Dietrich; Volk, Hans-Dieter; Sterry, Wolfram; Asadullah, Khusru; Sabat, Robert

    2006-12-01

    Due to their structural similarity, interleukin (IL)-19, IL-20, IL-22, IL-24 and IL-26 were combined with IL-10 in the so-called IL-10 family. To expand the knowledge on IL-19, IL-20 and IL-24, we systematically and quantitatively analysed the expression of these mediators and their receptor chains in vitro and in vivo under various conditions and in comparison with other IL-10 family members. In vitro, IL-19, IL-20 and IL-24 were produced not only by activated immune cells, particularly monocytes, but also to a similar extent by keratinocytes. IL-1beta increased the expression of these mediators 1000-fold (IL-19) and 10-fold (IL-20 and IL-24) in keratinocytes. In vivo, these cytokines were expressed preferentially in inflamed tissues. The absence of either R1 chain for the two types of receptor complexes for these cytokines (IL-20R1/IL-20R2 and IL-22R1/IL-20R2) on immune cells implies that they cannot act on these cells. In fact, IL-19, IL-20 and IL-24 did not induce activation of signal transducer and activator of transcription (STAT) molecules in immune cells. Instead, several tissues, particularly the skin, tissues from the reproductive and respiratory systems, and various glands appeared to be the main targets of these mediators. Keratinocytes expressed both receptor complexes; however, the expression of IL-22R1 was 10 times higher than that of IL-20R1. Interferon-gamma further increased the expression of IL-22R1 and decreased that of IL-20R1, suggesting that under T1 cytokine conditions these mediators primarily affect keratinocytes via the IL-22R1/IL-20R2 complex. In summary, these data support the notion that IL-19, IL-20 and IL-24 are distinct from classical ILs and constitute a separate subfamily of mediators within the IL-10 family.

  6. Bienes de titularidad pública: Patrimoniales y de dominio público. Una aproximación al sistema español

    Directory of Open Access Journals (Sweden)

    Luís Hernando Van-Strahlen-Fajardo

    2010-03-01

    Full Text Available Se realiza en este texto una aproximación puntual al régimen jurídico de los bienes de titularidad pública en España. Se comienza por la tradicional distinción entre bienes de dominio público y bienes patrimoniales o privados del Estado, donde se evidencia la ambigua frontera que separa al derecho público y al derecho privado. Luego se describen con mayor detenimiento las formas, las técnicas y los modos jurídicos para la adquisición, la enajenación, la cesión, la transferencia y la protección de los bienes de naturaleza patrimonial; así como una breve observación sobre una especie particular de estos últimos, que conforman el llamado patrimonio empresarial.

  7. Vivir bien, buen vivir: caminar con los dos pies (Living well, good living: walking with both feet

    Directory of Open Access Journals (Sweden)

    José María Tortosa

    2011-07-01

    Full Text Available ResumenEl texto recoge, a modo de introducción, una reflexión sobre el concepto del Buen Vivir/Vivir bien, los motivos de su relativo éxito en el contexto latinoamericano y su importancia tanto en el terreno simbólico como en su capacidad de revelar los errores del desarrollo en el sistema mundial. El Buen Vivir/Vivir Bien es un concepto en construcción, y de ahí la importancia de avanzar en la identificación de variables e indicadores que permitan su medición.AbstractAs an introduction, this text is a consideration on the concept of Good Living / Living Well, the reasons for its relative success in the Latin American context and its importance both as a symbolic field and its ability to reveal errors in the development in the global system. Good Living / Living Well is a concept under construction, hence the importance of progress in the identification of variables and indicators for its measurement.

  8. Ingénierie de la maintenance De la conception à l'exploitation d'un bien

    CERN Document Server

    Francastel, Jean-Claude

    2003-01-01

    La maintenance a évolué : d’abord confinée à l’entretien des équipements “réparer“ les pannes puis élargie à leur surveillance “prévoir” les pannes elle est intégrée aujourd’hui dès la phase de conception du produit avec notamment le concept de “maintenabilité” du produit. L’ingénierie de maintenance désigne ce processus d’accompagnement d’un bien industriel durant toutes les phases de son cycle de vie de la conception au démantèlement qui permet d’optimiser l’exploitation de ce bien et son coût global life cycle cost. Cet ouvrage décrit les différentes phases du cycle de vie en exposant les techniques qui permettent d’intégrer à chaque étape les concepts de maintenance.

  9. Tout va bien ! méthode de français : cahier d'exercices 1

    CERN Document Server

    Augé, H; Marlhens, C; Martin, L

    2005-01-01

    Tout va bien ! est une méthode de français destinée aux grands adolescents et adultes débutants ou faux-débutants. Ses objectifs respectent scrupuleusement les recommandations du Cadre européen commun de référence pour les langues, comme en témoigne le portfolio qui accompagne le livre de l'élève. Tout va bien ! propose : Des supports et des situations de communication authentiques ou proches de l'authentique, permettant à l'élève de se sensibiliser aux différents registres et de découvrir certains aspects de la culture francophone tout autant que la langue. De très nombreuses activités visant l'acquisition des quatre compétences de communication et l'utilisation de stratégies spécifiques. Un travail sur la grammaire et le vocabulaire associés aux situations et au service de la communication faisant une large place à l'observation et à la réflexion. Une invitation régulière à l'évaluation, au travail an autonomie et à l'auto-évaluation.

  10. Tout va bien ! méthode de français : cahier d'exercices 2

    CERN Document Server

    Augé, H; Marlhens, C; Martin, L

    2005-01-01

    Tout va bien ! est une méthode de français destinée aux grands adolescents et adultes débutants ou faux-débutants. Ses objectifs respectent scrupuleusement les recommandations du Cadre européen commun de référence pour les langues, comme en témoigne le portfolio qui accompagne le livre de l'élève. Tout va bien ! propose : Des supports et des situations de communication authentiques ou proches de l'authentique, permettant à l'élève de se sensibiliser aux différents registres et de découvrir certains aspects de la culture francophone tout autant que la langue. De très nombreuses activités visant l'acquisition des quatre compétences de communication et l'utilisation de stratégies spécifiques. Un travail sur la grammaire et le vocabulaire associés aux situations et au service de la communication faisant une large place à l'observation et à la réflexion. Une invitation régulière à l'évaluation, au travail an autonomie et à l'auto-évaluation.

  11. Il cervello Geniale

    Directory of Open Access Journals (Sweden)

    Tiziano Cornegliani

    2012-04-01

    Full Text Available Il genio, nella sua accezione corrente, è – secondo la definizione che ne fornisce la Treccani – “la somma potenza creatrice dello spirito umano, propria per virtù innata di pochi ed eccezionali individui, i quali per mezzo del loro talento giungono a straordinarie altezze nell’ambito dell’arte o della scienza”. E così in effetti è. Quando noi pensiamo al genio, la mente corre subito a Leonardo da Vinci, o Mozart, o Raffaello e Michelangelo, o naturalmente a Shakespeare. E ci chiediamo come sia possibile.

  12. Il muro nella mente:

    Directory of Open Access Journals (Sweden)

    Carmen Concilio

    2013-07-01

    Full Text Available A 78 anni, Nadine Gordimer, premio Nobel per la letteratura nel 1991, è infaticabile: il suo ultimo romanzo The Pick up è stato pubblicato negli Stati Uniti e in Inghilterra, dove ha ricevuto però tiepida accoglienza,e ora anche in Italia1. Alcuni mesi fa, tuttavia, Nadine Gordimer veniva ricordata dai giornali per un’impresa non letteraria: si tratta di un film-documentario dal titolo Johannesburg-Berlin, The Wall in the Mind, che Gordimer ha scritto e che ha girato con suo figlio, Hugo Cassirer, nel 1995-1996.

  13. Il Codice di autodisciplina

    OpenAIRE

    Cuccu, Francesco

    2013-01-01

    SOMMARIO: 1. Il nuovo Codice di Autodisciplina delle Società Quotate. – 2. Un breve sguardo di insieme. – 2.1. Composizione del consiglio di amministrazione. – 2.2. Ruolo e funzionamento del consiglio di amministrazione. – 2.3. L’organizzazione e i compiti dei comitati interni al consiglio. – 2.4. Sistema di controllo interno. – 3. Le raccomandazioni del Codice. – 3.1. Una nuova impostazione chiarificatrice. – 3.2. L’impulso dato dal d. lgs. 39/2010. – 4. I punti deboli del Codice. – 4.1. La ...

  14. Il bilinguismo disegnato

    Directory of Open Access Journals (Sweden)

    Graziella Favaro

    2013-07-01

    Full Text Available Il tema della diversità linguistica e del riconoscimento e della valorizzazione delle forme di bilinguismo dei bambini e dei ragazzi è cruciale nella scuola multiculturale e plurilingue. Ma quale rappresentazione della “mente bilingue” hanno i parlanti una o più lingue? Come immaginano la testa di chi e bilingue e dove collocano le diverse parole? Abbiamo chiesto agli alunni, piccoli e grandi, di alcune scuole di “disegnare il bilinguismo”: emergono in maniera vivida i “posti” diversi in cui le lingue si installano, i dubbi e le spiegazioni dei bambini, la necessità del controllo e la coloritura affettiva dell’uno e dell’altro idioma.  Drawing bilingualism The theme of linguistic diversity and the recognition and appreciation of forms of bilingualism in children and young people is crucial in a multilingual, multicultural school environment. But how do speakers of one or more languages imagine a “bilingual mind”? How do they imagine a bilingual person’s head and where are the different words located? We asked school children to “draw bilingualism”. The “placement” of the different languages, the children’s doubts and explanations and their need to check and the affective coloring of one and the other language emerged.

  15. Tradurre sotto il fascismo

    Directory of Open Access Journals (Sweden)

    Antonio Bibbò

    2012-12-01

    Full Text Available Cesare Pavese, per primo, parlò degli anni Trenta come del decennio – italiano – delle traduzioni. Christopher Rundle parte da lì per un importante studio sul "problema delle traduzioni" durante il fascismo, Publishing Translations in Fascist Italy, Peter Lang, 2010. Riesce così a fornire un panorama convincente di uno dei dibattiti più caratteristici del Ventennio, e a ridiscutere alcuni assunti come la centralità della letteratura anglo-americana nelle preoccupazioni dei "censori". Perché di amministrazione della cultura si parla: della censura porosa e discontinua – o comunque tardiva – messa in atto dal fascismo per limitare “l’invasione delle traduzioni”. Un interesse, quello nei confronti della politica e della censura editoriale durante i fascismi che sembra ormai centrale negli studi di italianistica e traduttologia.Il secondo volume recensito - Christopher Rundle and Kate Sturge, Translation under Fascism, Palgrave Macmillan, 2010 presenta una serie di studi sullo statuto delle traduzioni durante i regimi totalitari. Questa collezione di saggi va oltre i confini italiani e tedeschi e si occupa delle politiche di traduzione dei regimi fascisti europei, contribuendo ad allargare e mettere in discussione non solo la nostra conoscenza delle pratiche censorie in diversi ambiti espressivi, ma anche la stessa idea di regime fascista. 

  16. Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor.

    Science.gov (United States)

    Van Wagoner, N J; Oh, J W; Repovic, P; Benveniste, E N

    1999-07-01

    In the CNS, astrocytes are a major inducible source of interleukin-6 (IL-6). Although IL-6 has beneficial effects in the CNS because of its neurotrophic properties, its overexpression is generally detrimental, adding to the pathophysiology associated with CNS disorders. Many factors have been shown to induce IL-6 expression by astrocytes, particularly the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta). However, the role of IL-6 in its own regulation in astrocytes has not been determined. In this study, we examined the influence of IL-6 alone or in combination with TNF-alpha or IL-1beta on IL-6 expression. IL-6 alone had no effect on IL-6 expression; however, the addition of the soluble IL-6 receptor (sIL-6R) induced IL-6 transcripts. Addition of TNF-alpha or IL-1beta plus IL-6/sIL-6R led to synergistic increases in IL-6 expression. This synergy also occurred in the absence of exogenously added IL-6, attributable to TNF-alpha- or IL-1beta-induced endogenous IL-6 protein production. IL-6 upregulation seen in the presence of TNF-alpha or IL-1beta plus IL-6/sIL-6R was transcriptional, based on nuclear run-on analysis. Experiments were extended to other IL-6 family members to determine their role in IL-6 regulation in astrocytes. Oncostatin M (OSM) induced IL-6 alone and synergized with TNF-alpha for enhanced expression. These results demonstrate that IL-6/sIL-6R and OSM play an important role in the regulation of IL-6 expression within the CNS, particularly in conjunction with the proinflammatory cytokines TNF-alpha and IL-1beta.

  17. Associations of interleukin (IL)-1β, IL-1 receptor antagonist, and IL-10 with dental caries.

    Science.gov (United States)

    Cogulu, Dilsah; Onay, Huseyin; Ozdemir, Yasemin; I Aslan, Gulcin; Ozkinay, Ferda; Kutukculer, Necil; Eronat, Cemal

    2015-03-01

    Streptococcus mutans is important in dental caries. Although the role of cytokines in the pathogenesis of dental caries is not clear, components of S. mutans were found to stimulate production of pro-inflammatory cytokines. We examined the associations of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1ra), and IL-10 with dental caries. Unstimulated whole saliva and blood samples were obtained from 108 children aged 6-12 years with high caries (decayed, missing, or filled teeth [dmft/DMFT] index >4, n = 37), moderate caries (dmft/DMFT = 1-4, n = 37), or caries-free (dmft/DMFT = 0, n = 34). S. mutans level was classified as low (caries was not correlated with salivary or serum concentrations of the studied cytokines. S. mutans level positively correlated with saliva IL-1β concentration and inversely correlated with saliva IL-1ra concentration. There was no correlation of IL-1β, IL-1ra, or IL-10 gene polymorphisms with dental caries. S. mutans is important in stimulating saliva IL-1β and inhibiting IL-1ra. Future studies of associations between cytokines and dental caries should investigate additional cytokines and enroll a larger number of participants.

  18. Il danno alla persona del lavoratore: il mobbing orizzontale

    Directory of Open Access Journals (Sweden)

    Riccardo Gentile

    2011-12-01

    Full Text Available Sommario:1. Il mobbing tra diritto civile e diritto del lavoro – 2. Il fenomeno mobbing: gli studi iniziali e la definizione – 3. Le concrete condotte integranti fattispecie di mobbing – 4. Onere della prova – 5. Il mobbing orizzontale – 6. L’elemento soggettivo di colpevolezza del da­tore di lavoro nella responsabilità ex art. 2087 c.c. per mobbing orizzontale

  19. De Bienes de la Nación a Monumentos nacionales : Romanticismo y Patrimonio arquitectónico en Portugal

    Directory of Open Access Journals (Sweden)

    María Helena Maia

    2006-01-01

    Full Text Available Este artículo trata de la construcción de la noción de Patrimonio Arquitectónico en Portugal entre 1825 y 1880, período elegido por corresponder con aquél donde se define y consolida el proyecto de preservación romántico. De este modo, a partir del problema generado por la integración en los Bienes de la Nación de la voluminosa masa de bienes muebles e inmuebles, los «bienes nacionales», que hasta entonces habían estado mayoritariamente en poder de las Ordenes Religiosas y que incluían un elevado porcentaje de aquello que hoy se considera el patrimonio nacional. Se procura no solo comprender la evolución del cuadro patrimonial, sino también la de los discursos sobre el tema, la legislación promulgada y las prácticas efectivas de definición y salvaguardia de ese conjunto de edificios que, en este período, con el desarrollo de la consciencia patrimonial, se transforman en Monumentos Nacionales.This paper deals with the construction of the notion of Architectural Heritage in Portugal between 1825 and 1880, when the romantic «preservation project» was defined and consolidated. Having as a starting point the problem generated by the integration in the property of the Nation of a voluminous mass of properties, the so-called «national properties», that had until then been in the ownership of Religious Orders and include a high percentage of what is today considered our national heritage, we try not only to understand the evolution of the constitution of our architectural heritage, but also the several speeches on the subject, the promulgated legislation and the existing practices of definition and safeguard of this set of buildings that, at this time and due to the development of the consciousness of our heritage, were turned into National Monuments.

  20. Il bizzarro mondo dei quanti

    CERN Document Server

    Camejo, Silvia Arroyo

    2008-01-01

    Scritto prima dell'esame di maturità da una giovane di eccezionale talento, questo libro colma il vuoto esistente tra la letteratura divulgativa sulla fisica quantistica, che normalmente evita ogni formula matematica, e la letteratura specialistica, ben farcita, invece, di matematica avanzata. L'autrice, appena diciannovenne, con l'ausilio della sola matematica della scuola superiore, introduce il lettore ai principi della fisica dei quanti. Se ne ricava uno sguardo profondo sul microcosmo, il regno affascinante delle particelle elementari: oggetti il cui comportamento si distingue in modo drastico e fondamentale da tutto ciò a cui è avvezzo il nostro umano buonsenso. "Un libro... che avrei desiderato avere a 17 anni". Silvia Arroyo Camejo "In modo assolutamente preciso dal punto di vista fisico, l'autrice spiega con grande passione e divertimento i fondamenti della moderna fisica quantistica ... " Prof. Reinhold A. Bertlmann "Un libro stupefacente di un'autrice straordinaria! Si avverte il suo entusiasmo ...

  1. Il paesaggio dell’architettura

    Directory of Open Access Journals (Sweden)

    Paolo Zermani

    2015-11-01

    Full Text Available l saggio si articola come un’itinerario tra alcuni progetti italiani proposti come “occasioni di applicazione di un modo d’intendere l’architettura nel rapporto con il paesaggio smarrito, che cambia, ma potrebbe custodire ancora i valori di ciò che Heidegger definiva il “soggiorno”: la riconoscibilità intesa come misura”. Le architetture, come strumenti di conoscenza dello spazio, entrano nel paesaggio per diventarne speciali “misuratori”.Partendo dai luoghi del paesaggio padano, Noceto, con il Nuovo Municipio, con la minimale Cappella della Madonna, con il Padiglione privato, e Varano, con la Casa dal grande occhio spalancato sul bosco, alle terre umbre, con la Chiesa ed il Centro Parrocchiale di Perugia ed il Cimitero di Sansepolcro, si propone un percorso di ricerca di una identità dell’architettura italiana contemporanea nella dimensione paesaggistica. 

  2. Il cervello Ossessivo

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    Alessandra Gilardini

    2012-04-01

    Full Text Available Tutte le mattine esco e rientro in casa almeno 3 volte, con il dubbio di aver lasciato la luce della stanza accesa (fortuna della società elettrica quando non ci ritorno o l’armadio aperto (gioia del mio gatto quando non lo vedo. Arrivata al lavoro, la stessa cosa mi capita con la chiusura dell’auto, sia mai che la lasci aperta per farmi rubare quei pochi cd che ho comprato. Chi legge questo pezzo di certo si sta immedesimando nel mio inizio di giornata, anzi magari vince la partita su quante volte capita a lui/lei di rifare le stesse cose. Ma questo tipo di comportamento è figlio della disattenzione e della fretta. L’ossessione è ben altra cosa.

  3. Ornitonimia istriana: il pettirosso

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    Goran Filipi

    1992-12-01

    Full Text Available Il lavoro presenta un commento linguistico (soprattutto etimologico ai nomi del pettirosso nelle parlate istriane (istroveneto, istrioto, istrorumeno, croato, sloveno e montenegrino. Abbiamo raccolto i nomi in 135 luoghi della regione istro -quameri­ na (isola di Veglia compresa. Un elenco completo di tutti i nomi raccolti per questa specie verrà data alla fine del saggio. Per non confondere ii lettore le parole di tutti gli idiomi si riportano con la stessa grafia (I'alfabeto croato. L' accento viene segnato come si usa nelle rispettive parlate, tranne per le parole rumene dove si adotta ii sistema croato (perché corrisponde alla realtà fonetica dell' istrorumeno.

  4. Il Cinema Ritrovato

    OpenAIRE

    Taillibert, Christel

    2007-01-01

    Bologne, 1-8 juillet 2000 Girls, ladies, starsIl y a cinq ans, l’équipe de Bologne entamait un programme d’exploration des origines du star-system aux États-Unis avec un hommage rendu à Greta Garbo. Poursuivi depuis lors, ce projet prenait cette année la forme d’une section intitulée « Girls, Ladies, Stars : actrices américaines dans les années vingt », composée d’une vingtaine de films dédiés à neuf des plus grandes stars du cinéma muet outre-Atlantique. On put ainsi retrouver Pauline Freder...

  5. Il congiuntivo nel Goldoni

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    Mitja Skubic

    1970-11-01

    Full Text Available Nelle sue commeclie dialettali, Goldoni spesso ricorre al congiuntivo. La forma e tanto frequente e tanta è la coerenza nell'uso che ci testimonia della popolarita del congiuntivo nel veneziano parlato del suo tempo. E ancora non sapremmo elencarne tutte le forme, giacche, nel presente almeno, una speciale per il congiuntivo esiste quasi solo per la 3.a persona (come nell'indicativo, anche nel congiuntivo coincidono la 3.a del sg. e la 3.a del pl.. Pochi sono i verbi che mostrano una forma a parte per il congiuntivo nella La pers. sg. Citiamo dalla Casa nova: »fe conto che sia morto per vu«, I, 6; »E no le vol ehe maledissa sta casa e che diga roba de quel strambo de so fradelo«, II, 5; »se no volè che vaga, lasserò star«, II, 6; »bisognerà che dipenda da ela«, I, 6; »ghe son, bisogna che ghe staga, I, 2; »Bisognerà che m'inzegna da qualche altra banda«, I, 15. Quasi inesistente la 2.a pers. sg.; >>Siestu benedeta, dove che tu xe«, Rusteghi, II, 3. La scarsità della forma nel congiuntivo è da riconnettere alla scarsità della 2.a pers. in generale nelle commedie. Non ci sono forme del congiuntivo nel plurale: »avanti che lo spartimo, fevelo mostrare«, Baruffe, I, 5; »acciò che vegni a discreditar la mia casa«, Rusteghi, II, 3; »son vegnua a posta, acciò che parlè”, Rusteghi, III, 2.

  6. bien entendu’ vs ‘naturellement’: deux façons de désubjectiviser le dire

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    Elena Vladimirskaia

    2011-06-01

    Full Text Available Our study focuses on how the discourse markers (DM participate in the construction of discursive alterity. In our approach, the DM builds, for an assertion, a guarantor with its own semantics, which is the semantics of the lexical element constituting the basis of DM. Naturellement and bien entendu build referential value which ”disempowers” the speaker as a guarantor of his words. This desubjectivation is realized differently in each case analyzed, and is determined by the semantic identity of the DM. In this article we analyze how the DM build modulated commitment of the speaker in his role as the guarantor, convened by the semantics of the DM in the ”disresponsibilization” of the speaker as a guarantor of his own words.

  7. INDUSTRIA DE BIENES DE EQUIPO DE LA ECONOMÍA ESPAÑOLA: INSERCIÓN COMERCIAL Y CAMBIO ESTRUCTURAL

    Directory of Open Access Journals (Sweden)

    Fernando Luengo

    2011-01-01

    Full Text Available El texto examina el comercio exterior de la industria de bienes de equipo de la economía española en el entorno comunitario. Dicho análisis se realiza a partir de la evolución de un conjunto de indicadores reveladores de la calidad de la inserción comercial, el nivel tecnológico y la posición de gama. La principal conclusión es que, aun aceptando la diversidad de posiciones y trayectorias observadas en la industria, parece que ésta ocupa un espacio relativamente subordinado, instalada en segmentos de mercado de mediabaja tecnología y gama.

  8. Entendiendo el flujo de bienes intermedios en el nuevo siglo: hechos estilizados para explicar la especialización vertical

    OpenAIRE

    Domínguez, Juan Pablo

    2015-01-01

    El comercio mundial ha mostrado tasas de crecimiento constante durante los últimos 30 años. El proceso de globalización y la entrada al mercado de nuevas economías, como en el caso de China, ha dado una nueva dinámica del comercio en el sistema. Ésto ha tenido repercusiones en muchos ámbitos del mundo económico y político, muchos han acusado a China de tener competitividad "excesiva" en sus productos, que a su vez ha afectado a otras economías. Este trabajo analiza el flujo de bienes intermed...

  9. Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix.

    Science.gov (United States)

    Mindiola, Raimy; Caulejas, Diana; Núñez-Troconis, José; Araujo, Mary; Delgado, Mariela; Mosquera, Jesús

    2008-12-01

    Previous studies have shown the involvement of the immune response in the progression of human uterine cervix cancer. The aim of this study was to determine the expression of Interleukin-2 (IL-2), IL-2 receptor (IL-2R) and Interleukin 10 (IL-10) in different grades of cervical intraepithelial neoplasias of the exocervix (CIN 1, 2 and 3), and its relationship with the serum cytokine profiles and human papilomavirus (HPV) infection status. Indirect immunofluorescence was used to study the expression of IL-2, IL-2R and IL-10 in human cervical samples from 50 patients and 9 normal controls. Serum IL-2, IL-2R and IL-10 were measured by ELISA and HPV DNA and HPV types were identified by PCR. Increased number of IL-2, IL-2R and IL-10 positive cells were observed in the cervix from patients with CIN, associated with the grades of dysplasia. A significant correlation was observed between IL-2 and IL-2R (p>0.0001), IL-2 and IL-10 (p>0.0001), as well as IL-10 and IL-2R (p>0.0001). Twenty percent of patients were HPV positive and 84% of those patients were tissue cytokine positive. These results suggest that IL-2, IL-2R and IL-10 tissue expression may play a role in the development of cervical intraepithelial dysplasias.

  10. La materia e il cielo

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    Paolo Zermani

    2012-06-01

    Full Text Available Il testo che l’architetto Paolo Zermani propone per questo convegno si articola in tre parti. La prima è premessa ai due esempi proposti dalla propria vasta attività di progettista. Si tratta di mettere a sbalzo la liminalità dello spazio sacro, ossia il suo costruirsi al limite tra terra e cielo, confine materiale di più ampia significanza simbolica, tra fisica e metafisica, tra elementi evocativi, comunque materiali, e il “cielo dei cieli” di cui parla Agostino.  Intersezione di queste valenze è ancora il tipo architettonico, nella sintesi tra oriente ed occidente offerta dalla cultura romana e dalla forma della croce.Il significato del paesaggio nella composizione dell’architettura è esemplificato nella descrizione di due progetti: il Cimitero di Sansepolcro e il Nuovo Tempio per la Cremazione di Parma, il primo innestato nel Paesaggio Collinare di Piero della Francesca, il secondo incastonato nelle maglie della Limitatio Romana della pianura padana in prossimità di Valera, recinto sacro e nuovo altare della città di Parma. (abstract a cura di Luigi Bartolomei

  11. Transport and bioaccumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans at the Bien Hoa Agent Orange hotspot in Vietnam.

    Science.gov (United States)

    Van Thuong, Nguyen; Hung, Nguyen Xuan; Mo, Nguyen Thi; Thang, Nguyen Manh; Huy, Pham Quang; Van Binh, Hoang; Nam, Vu Duc; Van Thuy, Nguyen; Son, Le Ke; Minh, Nguyen Hung

    2015-10-01

    The Bien Hoa airbase (south of Vietnam) is known as one of the Agent Orange hotspots which have been seriously contaminated by Agent Orange/dioxin during the Vietnam War. Hundreds of samples including soil, sediment and fish were collected at the Bien Hoa Agent Orange hotspot for assessment of the environmental contamination caused by dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs). The toxicity equivalency quotient (TEQ) concentration of PCDD/Fs in soil and sediment varied from 7.6 to 962,000 and 17 to 4860 pg/g dry wt, respectively, implying very high contamination of PCDD/Fs in several areas. PCDD/F levels in fish ranged between 1.8 and 288 pg/g TEQ wet wt and was generally higher than advisory guidelines for food consumption. 2,3,7,8-Tetrachlorinated dibenzo-p-dioxins (2,3,7,8-TCDD) contributed 66-99 % of TEQ for most of the samples, suggesting 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) from Agent Orange as the major source of the contamination. The vertical transport of PCDD/Fs was observed in soil column with high TEQ levels above 1000 pg/g dry wt (Vietnamese limit for necessary remediation activities- TCVN 8183:2009 (2009)) even at a depth of 1.8 m. The vertical transport of PCDD/Fs has probably mainly taken place during the "Ranch Hand" defoliant spray activities due to the leaks and spills of phenoxy herbicides and solvents. The congener patterns suggest that transports of PCDD/Fs by weathering processes have led to their redistribution in the low-land areas. Also, an estimate for the total volume of contaminated soil requiring remediation to meet Vietnamese regulatory limits is provided.

  12. Il dolore nascosto: la malattia di Parkinson oltre il movimento

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    Lucio Tremolizzo

    2011-09-01

    Full Text Available Il quadro clinico della malattia di Parkinson non è limitato ai classici sintomi motori, ma è arricchito da numerosi disordini non motori, significativamente correlati alla qualità di vita del paziente e dei caregivers. Si stima che quasi il 90% dei pazienti presenti almeno un sintomo non motorio durante la malattia.

  13. L’arte di vedere il mondo. Il nuovo realismo

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    Aleksandr Voronskij

    2014-10-01

    Full Text Available Traduzione italiana del saggio di Aleksandr Voronskij L’arte di vedere il mondo. Il nuovo realismo (Iskusstvo videt’ mir. Sbornik statej, 1928, a cura di Cinzia De Lotto e Adalgisa Mingati.  

  14. LA TEORÍA GENERAL DE LA TRASMISIÓN DE BIENES Y EL REGISTRO DE LA PROPIEDAD EN ESPAÑA

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    Joaquín Sánchez Cebrián

    2008-01-01

    Full Text Available La circulación de los bienes en el tráfico jurídico por la voluntad de los particulares es un tema crucial que interesa, no sólo a las partes del contrato, sino a todos en general, y en particular, a los acreedores del transmitente o del adquirente y a los terceros adquirentes de derechos sobre el bien. En este trabajo se analizará el régimen de trasmisión de los bienes por negocio inter vivos en el Derecho español, dentro del marco europeo, y con particular referencia a la trasmisión inmobiliaria. España adopta un peculiar sistema de trasmisión de lo bienes, porque se establecen reglas genéricas aplicables con independencia de la naturaleza mueble o inmueble del bien; y junto a ellas, se superponen otras que tratan de fijar los efectos de la publicidad registral inmobiliaria. La coordinación entre dichas reglas produce un original resultado, que puede constituir el punto de encuentro de los diversos sistemas registrales europeos.

  15. IL-1Ra对阿霉素肾病大鼠血清IL-6、IL-10、IL-13、IL-1的影响%EFFECTS OF IL-1 RECEPTOR ANTAGONIST ON SERUM IL-6,IL-10,IL-13,AND IL-1 LEVELS IN ADRIAMYCIN NEPHROSIS IN RATS

    Institute of Scientific and Technical Information of China (English)

    林娜; 刘运广; 覃志坚; 李强

    2009-01-01

    目的:探讨IL-1Ra对阿霉素肾病大鼠血清IL-6、IL-10、IL-13 、IL-1的影响.方法:将大鼠随机分为正常对照组(A组, n=10)、阿霉素肾病组(B组,n=10)、阿霉素肾病IL-1Ra治疗组(C组,n=10)、阿霉素肾病生理盐水治疗组(D组,n=10), 2周后检测尿24 hUP、血清IL-6、IL-10、IL-13、IL-1、Al、T-ch、BUN、Scr.结果:B、C、D组血清IL-6、IL-10、IL-13水平明显高于A组(P0.05).结论:IL-1Ra对阿霉素肾病大鼠有明显治疗作用的同时能提高抗炎细胞因子IL-6、IL-10、IL-13的血清水平.

  16. IL-5 and IL-5 receptor in asthma

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    Kotsimbos ATC

    1997-01-01

    Full Text Available Eosinophils, along with mast cells are key cells involved in the innate immune response against parasitic infection whereas the adaptive immune response is largely dependent on lymphocytes. In chronic parasitic disease and in chronic allergic disease, IL-5 is predominantly a T cell derived cytokine which is particularly important for the terminal differentiation, activation and survival of committed eosinophil precursors. The human IL-5 gene is located on chromosome 5 in a gene cluster that contains the evolutionary related IL-4 family of cytokine genes. The human IL-5 receptor complex is a heterodimer consisting of a unique a subunit (predominantly expressed on eosinophils and a beta subunit which is shared between the receptors for IL-3 & GM-CSF (more widely expressed. The a subunit is required for ligand-specific binding whereas association with the beta subunit results in increased binding affinity. The alternative splicing of the alphaIL-5R gene which contains 14 exons can yield several alphaIL-5R isoforms including a membrane-anchored isoform (alphaIL-5Rm and a soluble isoform (alphaIL-5Rs. Cytokines such as IL-5 produce specific and non-specific cellular responses through specific cell membrane receptor mediated activation of intracellular signal transduction pathways which, to a large part, regulate gene expression. The major intracellular signal transduction mechanism is activation of non-receptor associated tyrosine kinases including JAK and MAP kinases which can then transduce signals via a novel family of transcriptional factors named signal transducers and activators of transcription (STATS. JAK2, STAT1 and STAT 5 appear to be particularly important in IL-5 mediated eosinophil responses. Asthma is characterized by episodic airways obstruction, increased bronchial responsiveness, and airway inflammation. Several studies have shown an association between the number of activated T cells and eosinophils in the airways and abnormalities

  17. IL-1b, IL-6 and IL-8 Levels in Gyneco-Obstetric Infections

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    Beatriz Basso

    2005-01-01

    Full Text Available Objective. During pregnancy cytokines and inflammatory mediators stimulate the expression of prostaglandin, the levels of which determine the onset of labor. The aim of this work was to study interleukin IL-1β, IL-6 and IL-8 levels in the vaginal discharge, serum and urine of pregnant women with genitourinary infection before and after specific treatment. One hundred and fifty-one patients were studied during the second or third trimester of their pregnancy.

  18. La protección de bienes urbanos. Avances en la política pública de Medellín

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    Clara In��s Atehortúa-Arredondo

    2010-12-01

    Full Text Available La problemática de la protección de bienes en el país es una pregunta obligatoria para quienes tienen dentro de su labor el reconocimiento, la restitución y la reparación de las víctimas del desplazamiento forzado. Uno de los puntos que deben analizarse dentro de esta problemática es lo concerniente a la protección de bienes urbanos y cuya responsabilidad está en cabeza de los municipios. El desarrollo de una política pública por parte de la ciudad de Medellín para la protección de bienes es un avance significativo para la construcción de protocolos y para la reivindicación de derechos de quienes han abandonado por causa de la violencia o han sido despojados de sus viviendas en lo urbano.

  19. Bienes de titularidad pública: Patrimoniales y de dominio público. Una aproximación al sistema español

    OpenAIRE

    Luís Hernando Van-Strahlen-Fajardo

    2010-01-01

    Se realiza en este texto una aproximación puntual al régimen jurídico de los bienes de titularidad pública en España. Se comienza por la tradicional distinción entre bienes de dominio público y bienes patrimoniales o privados del Estado, donde se evidencia la ambigua frontera que separa al derecho público y al derecho privado. Luego se describen con mayor detenimiento las formas, las técnicas y los modos jurídicos para la adquisición, la enajenación, la cesión, la transferencia y la protecció...

  20. Abitare il paradosso

    Directory of Open Access Journals (Sweden)

    Daniele Capra

    2011-10-01

    Full Text Available

    L'articolo intende presentare spunti per una rilettura delle tesi esposte da Donald Woods Winnicott secondo una prospettiva filosofica di stampo pragmatico-ermeneutico, con particolare riferimento al tema della istituzione e costituzione della relazione oggettuale, nell’intento di ricercare, rendendolo evidente, il lgouo dvoe un oegtgto copmlesso cmoe qeutsa fsrae asusme un singifiacto e la fliosoifa, sloo in un mdoo più avevrtito riseptto alle sicezne, è psosiblie.

    To inhabit the paradox

    The article aims to present ideas for a new reading of theses expounded by Donald Woods Winnicott, according to a philosophical perspective of pragmatic-hermeneutic kind, with special reference to the establishment and constitution of the object relationship, in order to search, making it clear, the palce wehre an ojbect as copmelx as tihs prahse tkeas on a maeinng and piholposhy, olny in a way mroe exerpineced tahn secinecs, is psoislbe.

     

     

  1. Administración económica del distrito inquisitorial de Valencia: la receptoría de bienes confiscados (1482-1493)

    OpenAIRE

    Tomás Botella, Bernardo

    2016-01-01

    El objeto de esta tesis doctoral es la receptoría de bienes confiscados de la Inquisición de Valencia, su estructura burocrática y sus procedimientos de actuación sobre la sociedad valenciana bajomedieval. Esta oficina se encargaba de ejecutar el secuestro y confiscación del patrimonio de los herejes condenados, así como de gestionar y liquidar dichos bienes una vez incorporados al fisco regio. Además, se ha analizado la evolución institucional que experimentó el Santo Oficio durante el perio...

  2. "Penuria pauperum clamat".Discursos letrados sobre los bienes eclesiásticos (Siglos XII-XVI): doctrinas ideales y realidades típicas

    OpenAIRE

    Rafael M. Pérez García

    2014-01-01

    Este trabajo estudia los orígenes y el desarrollo de los discursos letrados sobre los bienes eclesiásticos entre los siglos XII y XVI. Generados en el marco de los procesos reformistas que se producen en la Iglesia durante este arco de tiempo, estos discursos acabaron conformando las mentalidades sociales sobre el clérigo ideal y su relación con los bienes materiales. This article studies the origins and development of the highbrow literature about the ecclesiastical properties...

  3. Determinación de los precios implícitos en bienes inmuebles : una alternativa a la modelización hedónica

    OpenAIRE

    2004-01-01

    RESUMEN Recientemente un nuevo enfoque para estimar el valor de bienes inmuebles está siendo cada vez más usado. Para ello se usan atributos internos del bien, y externos, del entorno, pues ambos son percibidos de forma diferente en el mercado. Así pues, propiedades con nivel de precios similar son consideradas como claramente diferenciadas en los mercados inmobiliarios. Las técnicas de Inteligencia Arti cial proporcionan nuevas posibilidades, en comparación con la modelización econométrica ...

  4. La transmisión de bienes muebles por particulares a empresarios en el impuesto sobre transmisiones patrimoniales y actos jurídicos documentados

    OpenAIRE

    Campos Moscoso, Mariano

    2015-01-01

    El trabajo de investigación tiene como objeto de estudio el análisis crítico de la Sentencia del Tribunal Supremo de 18 de enero de 1996, sobre la transmisión de objetos de oro por particulares a empresarios, estableciendo el Alto Tribunal que la transmisión de los citados bienes no se encuentra sujeta a gravamen en el Impuesto sobre Transmisiones Patrimoniales y AJD, concepto transmisiones patrimoniales onerosas, al ser el adquirente de los bienes un empresario que adquiere di...

  5. Costes de transacción vs costes de jerarquía en la provisión de bienes: Una interpretación smithiana

    OpenAIRE

    Trincado Aznar, Estrella

    2007-01-01

    En la teoría de Adam Smith, las jerarquías económicas nunca pueden reducir los costes de transacción del mercado. Para demostrarlo, el artículo estudia la definición de libertad Smithiana, que lleva a que cualquier imposición sobre la actividad independiente y creativa sea «costosa». También explica el tratamiento del tema de la provisión de bienes privados y públicos en la Riqueza de las Naciones. Por tanto, por un lado se describe la naturaleza de la empresa, que provee bienes privados, y p...

  6. IL-3 and IL-33 induces IL-9 secretion from human basophils

    DEFF Research Database (Denmark)

    Poulsen, Britta C.; Jensen, Bettina Margrethe; Blom, Lars

    Background IL-9 has been suggested to play an important role in chronic inflammation due to its effect on remodeling and cell recruitment. Since basophils can be found in inflamed tissue, we wanted to test if human basophils are capable of secreting IL-9 under the influence of growth or tissue...... factors like IL-3 or IL-33, respectively. Methods Basophils, purified from buffy coat blood by negative selection (purity > 95%), were cultured for 24 hours in RPMI culture medium (1x106 cells/ml) supplemented with 5% human serum, and IL-3 (10 ng/ml) and/or IL-33 (50 ng/ml). The cells were then analysed...... by FACS for ST2 expression where basophils were gated as FceRIa+CD3-CD14-CD19-CD56-. The supernatant was tested for IL-9 using a multiplex magnetic bead assay. Results Human basophils have recently been described to express the IL-33 receptor ST2. In agreement with previous findings, our results showed...

  7. IL CAMPO GEOMAGNETICO

    Directory of Open Access Journals (Sweden)

    F. MOLINA

    1972-06-01

    Full Text Available Questo lavoro non è un trattato sul campo geomagnetico e nemmeno
    una rassegna sull'argomento, almeno nel significato che normalmente
    si attribuisce al termine « rassegna »; esso è semplicemente
    un tentativo di condensare in termini comprensibili agli studiosi non
    specializzati ciò che oggi si sa o si ipotizza sul magnetismo terrestre
    e sulle sue cause. Chi scrive si è sempre trovato a disagio di fronte
    alle richieste di una spiegazione sull'origine del campo magnetico
    terrestre: o si cerca di cavarsela con poche parole (« si tratta di correnti
    elettriche indotte nell'interno della Terra » che possono forse accontentare
    chi non si occupa in modo particolare di problemi scientifici
    ma non possono soddisfare un fisico, oppure ci si sente obbligati a
    tentare faticosamente di approfondire, sia per capirli personalmente
    che per poterli poi spiegare agli altri, argomenti e ragionamenti che
    sono in realtà accessibili solo a un fisico teorico ben preparato. Apparentemente
    non esiste una via di mezzo, come del resto in molti altri
    campi della fisica contemporanea.
    La presente monografia rappresenta appunto il tentativo di trovare
    questa via di mezzo: nel terzo capitolo, dedicato alle teorie sull'origine
    del campo geomagnetico, si cerca di descrivere qualitativamente
    i principali processi fisici proposti come sorgenti del campo,
    dopo un accenno ai fondamenti fisici e matematici sui quali sono state
    elaborate le varie teorie. Senza farmi soverchie illusioni di essere riuscito
    nell'intento, mi dichiarerei tuttavia soddisfatto se questo lavoro
    destasse sull'argomento l'interesse di qualche giovane ricercatore, incoraggiandolo
    ad un approfondimento.

  8. Le Prophète de l’islam serait-il irreprésentable ?

    OpenAIRE

    2015-01-01

    L’article entreprend de venir à bout de la rumeur tenace, celle d’une stricte interdiction de la représentation figurative de Mohammed dans les beaux-arts. Il commence par rappeler qu’il n’y en a pas la moindre trace dans le Coran, qui ne condamne que l’idolâtrie, ni dans les hadiths, où pointe il est vrai une vive hostilité à l’égard des créateurs de formes et de leurs productions. On ne trouve pas en islam de théorisation de l’aniconisme ou de l’hostilité aux images, si bien que la pratique...

  9. Il discreto e il continuo complementarita in matematica

    CERN Document Server

    Kuyk, Willem

    1982-01-01

    Nato dall'esperienza didattica dell'autore, il libro si presenta come un testo interdisciplinare di matematica e di filosofia, inteso a fornire un quadro complessivo dello stato attuale dei fondamenti della matematica.

  10. IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13

    Directory of Open Access Journals (Sweden)

    Michoud Marie-Claire

    2008-12-01

    Full Text Available Abstract Background IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Rα1 and IL-4Rα subunits with subsequent activation of signal transducer and activator of transcription 6 (STAT6. The IL-13Rα2 receptor may act as a decoy receptor. In human airway smooth muscle (HASM cells, IL-13 enhances cellular proliferation, calcium responses to agonists and induces eotaxin production. We investigated the effects of pre-treatment with IL-4, IL-13 and IFN-γ on the responses of HASM cells to IL-13. Methods Cultured HASM were examined for expression of IL-13 receptor subunits using polymerase chain reaction, immunofluorescence microscopy and flow cytometry. Effects of cytokine pre-treatment on IL-13-induced cell responses were assessed by looking at STAT6 phosphorylation using Western blot, eotaxin secretion and calcium responses to histamine. Results IL-13Rα1, IL-4Rα and IL-13Rα2 subunits were expressed on HASM cells. IL-13 induced phosphorylation of STAT6 which reached a maximum by 30 minutes. Pre-treatment with IL-4, IL-13 and, to a lesser degree, IFN-γ reduced peak STAT6 phosphorylation in response to IL-13. IL-13, but not IFN-γ, pre-treatment abrogated IL-13-induced eotaxin secretion. Pre-treatment with IL-4 or IL-13 abrogated IL-13-induced augmentation of the calcium transient evoked by histamine. Cytokine pre-treatment did not affect expression of IL-13Rα1 and IL-4Rα but increased expression of IL-13Rα2. An anti-IL-13Rα2 neutralizing antibody did not prevent the cytokine pre-treatment effects on STAT6 phosphorylation. Cytokine pre-treatment increased SOCS-1, but not SOCS-3, mRNA expression which was not associated with significant increases in protein expression. Conclusion Pre-treatment with IL-4 and IL-13, but not IFN-γ, induced desensitization of the HASM cells to IL-13 as measured by eotaxin secretion and calcium transients to histamine

  11. El castellano bien templado

    OpenAIRE

    Sáenz, Miguel

    2009-01-01

    Este artículo se sirve de la música para establecer un paralelismo entre ésta y la traducción, pues si la traducción es una interpretación (musical) de un texto, puede haber innumerables traducciones válidas, pudiendo haber alguna “de referencia”. Además, se plantea que las facultades son como conservatorios donde los futuros traductores estudian técnicas y aprenden fundamentos teóricos (que compara con el solfeo, la armonía y la composición) y que las traducciones “envejecen” porque su es...

  12. II feticcio e il visuale

    Directory of Open Access Journals (Sweden)

    Canevacci, Massimo

    1998-12-01

    Full Text Available The author illustrates the application of methodological fetishism to the new «visual goods» and to the «biography» of wealth. Three aspects of current visual communication can be subject to ethnographic scrutiny: the bodywork of a car (of an Opel-Tigra, for example, a wall (such as the Berlín Wall and an inorganic body (such as a metropolitan counterculture. The author aims at the (iissolution of these visual fetishes.En este ensayo se aplica el fetichismo metodológico a los nuevos «bienes-visuales» y a la «biografía» de los bienes. La mirada etnográfica permite analizar tres aspectos de la comunicación visual contemporánea: el cuerpo de un automóvil (Opel-Tigra, el cuerpo de un muro (el de Berlín, el cuerpo inorgánico (una contracultura metropolitana. El objetivo es la disolución de los fetiches visuales.

  13. IL6 and IL10 are genetic susceptibility factors of periodontal disease

    Directory of Open Access Journals (Sweden)

    Luca Scapoli

    2012-01-01

    Conclusions: The present investigation indicated that polymorphisms of IL6 and IL10 constitute risk factors for chronic periodontitis, while there was no evidence implicating a specific IL1A or IL1B genotype.

  14. Environmental Health Risk Assessment of Dioxin Exposure through Foods in a Dioxin Hot Spot—Bien Hoa City, Vietnam

    Science.gov (United States)

    Tuyet-Hanh, Tran Thi; Vu-Anh, Le; Ngoc-Bich, Nguyen; Tenkate, Thomas

    2010-01-01

    This study used the Australian Environmental Health Risk Assessment Framework to assess the human health risk of dioxin exposure through foods for local residents in two wards of Bien Hoa City, Vietnam. These wards are known hot-spots for dioxin and a range of stakeholders from central government to local levels were involved in this process. Publications on dioxin characteristics and toxicity were reviewed and dioxin concentrations in local soil, mud, foods, milk and blood samples were used as data for this risk assessment. A food frequency survey of 400 randomly selected households in these wards was conducted to provide data for exposure assessment. Results showed that local residents who had consumed locally cultivated foods, especially fresh water fish and bottom-feeding fish, free-ranging chicken, duck, and beef were at a very high risk, with their daily dioxin intake far exceeding the tolerable daily intake recommended by the WHO. Based on the results of this assessment, a multifaceted risk management program was developed and has been recognized as the first public health program ever to have been implemented in Vietnam to reduce the risks of dioxin exposure at dioxin hot-spots. PMID:20623031

  15. Environmental health risk assessment of dioxin exposure through foods in a dioxin hot spot-Bien Hoa City, Vietnam.

    Science.gov (United States)

    Tuyet-Hanh, Tran Thi; Vu-Anh, Le; Ngoc-Bich, Nguyen; Tenkate, Thomas

    2010-05-01

    This study used the Australian Environmental Health Risk Assessment Framework to assess the human health risk of dioxin exposure through foods for local residents in two wards of Bien Hoa City, Vietnam. These wards are known hot-spots for dioxin and a range of stakeholders from central government to local levels were involved in this process. Publications on dioxin characteristics and toxicity were reviewed and dioxin concentrations in local soil, mud, foods, milk and blood samples were used as data for this risk assessment. A food frequency survey of 400 randomly selected households in these wards was conducted to provide data for exposure assessment. Results showed that local residents who had consumed locally cultivated foods, especially fresh water fish and bottom-feeding fish, free-ranging chicken, duck, and beef were at a very high risk, with their daily dioxin intake far exceeding the tolerable daily intake recommended by the WHO. Based on the results of this assessment, a multifaceted risk management program was developed and has been recognized as the first public health program ever to have been implemented in Vietnam to reduce the risks of dioxin exposure at dioxin hot-spots.

  16. Environmental Health Risk Assessment of Dioxin Exposure through Foods in a Dioxin Hot Spot—Bien Hoa City, Vietnam

    Directory of Open Access Journals (Sweden)

    Tran Thi Tuyet-Hanh

    2010-05-01

    Full Text Available This study used the Australian Environmental Health Risk Assessment Framework to assess the human health risk of dioxin exposure through foods for local residents in two wards of Bien Hoa City, Vietnam. These wards are known hot-spots for dioxin and a range of stakeholders from central government to local levels were involved in this process. Publications on dioxin characteristics and toxicity were reviewed and dioxin concentrations in local soil, mud, foods, milk and blood samples were used as data for this risk assessment. A food frequency survey of 400 randomly selected households in these wards was conducted to provide data for exposure assessment. Results showed that local residents who had consumed locally cultivated foods, especially fresh water fish and bottom-feeding fish, free-ranging chicken, duck, and beef were at a very high risk, with their daily dioxin intake far exceeding the tolerable daily intake recommended by the WHO. Based on the results of this assessment, a multifaceted risk management program was developed and has been recognized as the first public health program ever to have been implemented in Vietnam to reduce the risks of dioxin exposure at dioxin hot-spots.

  17. El consumo de bienes religiosos. Una introducción económica al caso español

    Directory of Open Access Journals (Sweden)

    Brañas-Garza, Pablo

    2003-08-01

    Full Text Available This paper uses the Economic of Religion issues to explore Spanish religious behaviour. Under this microeconomic framework religious practise is considered "rational" using Azzi-Ehrenberg (1975 arguments: salvation, social and professional motives. We test if that hypotheses may explain Spanish religious activity. To this end we run descriptive and multivariate analysis that allows us to conclude the following: theoretical models well perform Spanish data; gender, ageing, family size and education are positive determinant of church-attendance; the influence of parents behaviour on children religious activity.

    Este trabajo explora el comportamiento religioso de los españoles desde el enfoque de la Economía de la Religión. En un marco microeconómico y utilizando los argumentos de Azzi- Ehrenberg (1975 —motivo salvación, consumo y profesional—, la práctica religiosa resulta racional. En esta investigación estudiamos si estas hipótesis pueden explicar el comportamiento religioso de los españoles. Para ello se realizan análisis descriptivos y multivariantes que nos permiten concluir que: los modelos teóricos explican bien los datos españoles; que el sexo, la edad, el tamaño de la familia y la educación son determinantes positivos de la asistencia a iglesia; que el ejemplo de los padres influye en la actividad religiosa actual de los hijos.

  18. Ingreso y bienes de la población de edad media y avanzada en México

    Directory of Open Access Journals (Sweden)

    Rebeca Wong

    2003-01-01

    Full Text Available El propósito de este artículo es resumir el monto y los tipos de ingreso que percibe y bienes que posee la población de edad media y avanzada en México. Se usan datos de la nueva Encuesta Nacional sobre Salud y Envejecimiento en México (Enasem 2001, un estudio prospectivo de panel con representación nacional de las personas de 50 años de edad y más. Los resultados confirman las hipótesis formuladas: la distribución del ingreso y la riqueza están sesgadas en favor de ciertos grupos, sobre todo aquéllos con mayor educación; la composición de la riqueza se da principalmente en forma no financiera y el apoyo familiar es una fuente de ingreso importante; la asociación entre riqueza y salud es positiva en general, lo cual es consistente con la literatura internacional. Además se encuentra que la riqueza acumulada está distribuida más equitativamente que el ingreso, y se concluye que el indicador de riqueza ofrece una dimensión de análisis adicional al ingreso, con potencial para contribuir a los estudios del bienestar de la población en edad media y avanzada en México.

  19. Los expedientes de incautación de bienes. El caso del partido judicial de Aracena (Huelva, 1936-1939

    Directory of Open Access Journals (Sweden)

    Pedro Jesús Feria Vázquez

    2009-12-01

    Full Text Available En este trabajo se expone cómo la justicia en el bando nacional durante la Guerra Civil fue una herramienta en manos de las tropas del general Franco, ejerciéndose una política de represión económica a fin de financiar los gastos de la guerra y del aparato estatal que iban construyendo. Es lo que podríamos denominar como represión económica, o cómo el franquismo, además de asesinar o encarcelar a los opositores, les despojó de sus bienes, con la intención de anularles completamente y de paso financiar su cruzada.____________________ABSTRACT:This work presents how during the Civil War justice in the nationalist camp was a tool in the hands of general Franco’s troops, who exercised a policy of economic repression in order to cover the costs of the war and the state apparatus they were creating. This is what we can call economical repression, or how Franco’s regime, in addition to assassinating or imprisoning the opponents, stripped them of all they had, with an intention to eliminate them completely and at the same time finance their own crusade.

  20. DERECHO Y ECONOMÍA DE LA FUNCIÓN PÚBLICA DE REGISTRO DE BIENES

    Directory of Open Access Journals (Sweden)

    Rodrigo Andrés Moscoso Valderrama

    2012-01-01

    Full Text Available Bouckaert describe la función registral de propiedades o lo que él denomina el "sistema de títulos", como "(… una institución jurídica basada en la evidencia escrita del estado legal de unos activos que son sistemáticamente registrados". (Bouckaert, 2010. En aquellos ordenamientos jurídicos en donde la transmisión de la propiedad se realiza mediante el sistema registral, la eficiencia del orden económico de dicha jurisdicción dependerá, en gran medida, de la coherencia del sistema registral con la definición y el contenido de los derechos de propiedad en el mercado. ¿Puede entonces ser un error el condicionar la transmisión de la propiedad a la realización de un registro bajo un conjunto de requisitos legales? ¿Qué determina la necesidad o no del registro desde la teoría jurídica de los bienes? Este trabajo pretende entonces hacer una reflexión de esta temática desde el ordenamiento jurídico colombiano.

  1. La sucesión a los bienes de Juan Antonio Llorente, en París

    Directory of Open Access Journals (Sweden)

    de la Lama, Enrique

    2003-06-01

    Full Text Available Llorente, one of the most famous critics of the Spanish Inquisition, «afrancesado » in top responsibility and well known in his own physical feature wich Goya made of him, died without leaving his last will. The present work studies in detail the notary documents referring to «succesio ab intestato», wich permit to know his library, his personal belongings as well as information about an illegitimate daughter born in France during his exile.

    Llorente, uno de los más afamados críticos de la Inquisición de España, afrancesado de alta responsabilidad y bien conocido en su mismo semblante físico por el retrato que le hizo Goya, falleció sin hacer testamento. El presente trabajo estudia detalladamente los documentos notariales de la sucesión «ab intestato», que permiten conocer su biblioteca y sus enseres personales, así como la noticia de una hija natural nacida en Francia durante su exilio.

  2. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNγ production

    Science.gov (United States)

    Lemos, Henrique P.; Grespan, Renata; Vieira, Silvio M.; Cunha, Thiago M.; Verri, Waldiceu A.; Fernandes, Karla S. S.; Souto, Fabricio O.; McInnes, Iain B.; Ferreira, Sergio H.; Liew, Foo Y.; Cunha, Fernando Q.

    2009-01-01

    IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN γ production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-17 antibodies, COX inhibitors, IL-12, or IFNγ but was enhanced by prostaglandin E2 (PGE2). IL-23-induced IL-17 production was increased by PGE2 and suppressed by COX-inhibition or IL-12. Furthermore, COX inhibition failed to reduce IL-23-induced neutrophil migration in IL-12- or IFNγ-deficient mice. IL-17-induced neutrophil migration was not affected by COX inhibitors, IL-12, or IFNγ but was inhibited by MK886 (a leukotriene synthesis inhibitor), anti-TNFα, anti-CXCL1, and anti-CXCL5 antibodies and by repertaxin (a CXCR1/2 antagonist). These treatments all inhibited mBSA- or IL-23-induced neutrophil migration. IL-17 induced neutrophil chemotaxis through a CXC chemokines-dependent pathway. Our results suggest that prostaglandin plays an important role in IL-23-induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNγ production. We thus provide a mechanism for the pathogenic role of the IL-23/IL-17 axis in RA and also suggest an additional mechanism of action for nonsteroidal anti-inflammatory drugs. PMID:19289819

  3. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.

    Science.gov (United States)

    Lemos, Henrique P; Grespan, Renata; Vieira, Silvio M; Cunha, Thiago M; Verri, Waldiceu A; Fernandes, Karla S S; Souto, Fabricio O; McInnes, Iain B; Ferreira, Sergio H; Liew, Foo Y; Cunha, Fernando Q

    2009-04-07

    IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN gamma production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-17 antibodies, COX inhibitors, IL-12, or IFNgamma but was enhanced by prostaglandin E(2) (PGE(2)). IL-23-induced IL-17 production was increased by PGE(2) and suppressed by COX-inhibition or IL-12. Furthermore, COX inhibition failed to reduce IL-23-induced neutrophil migration in IL-12- or IFNgamma-deficient mice. IL-17-induced neutrophil migration was not affected by COX inhibitors, IL-12, or IFNgamma but was inhibited by MK886 (a leukotriene synthesis inhibitor), anti-TNFalpha, anti-CXCL1, and anti-CXCL5 antibodies and by repertaxin (a CXCR1/2 antagonist). These treatments all inhibited mBSA- or IL-23-induced neutrophil migration. IL-17 induced neutrophil chemotaxis through a CXC chemokines-dependent pathway. Our results suggest that prostaglandin plays an important role in IL-23-induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNgamma production. We thus provide a mechanism for the pathogenic role of the IL-23/IL-17 axis in RA and also suggest an additional mechanism of action for nonsteroidal anti-inflammatory drugs.

  4. Variants, Layers of Authorial Intervention, and Texts in Lope de Vega’s La buena guarda and La encomienda bien guardada autograph manuscript

    Directory of Open Access Journals (Sweden)

    Stefania Capoia

    2014-01-01

    Full Text Available In this article I study, analyze and classify the variant readings and the different layers of authorial intervention that appear in Lope de Vega’s La buena guarda and La encomienda bien guardada manuscript. I contend that the second version of the work should be edited, a possibility thus far neglected by modern editors.

  5. Correlation of Serum IL-12, IL-10 and IL-18 and TB%血清IL-12、IL-10及IL-18与肺结核的相关性研究

    Institute of Scientific and Technical Information of China (English)

    罗建业; 邓菲丹

    2015-01-01

    Objective To investigate the effects of tuberculosis patients serum interleukin-12(IL-12), interleukin-10 (IL-10) and interleukin-18(IL-18) expression in and of serum IL-12, IL-10 and IL-18 with tuberculosis relevance. Methods Randomly select the first 80 cases of pulmonary tuber-culosis retreatment group, 120 cases of pulmonary tuberculosis for initial treatment group, 100 cases of physical health for the control group; blood were detected three groups of IL-12, IL-10 and IL-18 levels and compared three groups of serum IL-12, IL-10 and IL-18 levels and clinical significance proposed. Results Before treatment, the retreatment group serum IL-12, IL-10 and IL-18 levels were significantly higher than the initial treatment group and the control group, which differences were statistically significant (P0.05). Conclusions IL-12, IL-10 and IL-18 involved in the incidence of tuberculosis, development, testing related to serum lev-els of inflammatory factors contribute to the assessment of pulmonary disease and therapeutic effi-cacy of the change process.%目的:探讨肺结核患者对血清白细胞介素-12(IL-12)、白细胞介素-10(IL-10)和白细胞介素-18(IL-18)表达的影响,并分析血清IL-12、IL-10和IL-18与肺结核的相关性。方法随机选择首次复治肺结核80例为复治组,初治肺结核120例为初治组,体检健康100例为对照组;分别检测三组的血IL-12、IL-10和IL-18水平,并比较三组血清IL-12、IL-10和IL-18水平与临床意义。结果治疗前,复治组血清IL-12、IL-10和IL-18水平均明显高于初治组、对照组,差异均有统计学意义(P<0.05);初治组血清IL-12、IL-10和IL-18水平均与对照组比较,差异均有统计学意义(P<0.05);治疗后,三组的血清IL-12、IL-10和IL-18水平均比较,差异均无有统计学意义(P>0.05)。结论 IL-12、IL-10和IL-18参与了肺结核的发生、发展,检测相关血清炎症因子水平有助于对肺结核疾病

  6. Association study of functional polymorphisms in interleukins and interleukin receptors genes: IL1A, IL1B, IL1RN, IL6, IL6R, IL10, IL10RA and TGFB1 in schizophrenia in Polish population.

    Science.gov (United States)

    Kapelski, Pawel; Skibinska, Maria; Maciukiewicz, Malgorzata; Wilkosc, Monika; Frydecka, Dorota; Groszewska, Agata; Narozna, Beata; Dmitrzak-Weglarz, Monika; Czerski, Piotr; Pawlak, Joanna; Rajewska-Rager, Aleksandra; Leszczynska-Rodziewicz, Anna; Slopien, Agnieszka; Zaremba, Dorota; Twarowska-Hauser, Joanna

    2015-12-01

    Schizophrenia has been associated with a large range of autoimmune diseases, with a history of any autoimmune disease being associated with a 45% increase in risk for the illness. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopment, neuroplasticity and neurotransmission. In particular, increases or imbalance in cytokine before birth or during the early stages of life may affect neurodevelopment and produce vulnerability to the disease. A total of 27 polymorphisms of IL1N gene: rs1800587, rs17561; IL1B gene: rs1143634, rs1143643, rs16944, rs4848306, rs1143623, rs1143633, rs1143627; IL1RN gene: rs419598, rs315952, rs9005, rs4251961; IL6 gene: rs1800795, rs1800797; IL6R gene: rs4537545, rs4845617, rs2228145, IL10 gene: rs1800896, rs1800871, rs1800872, rs1800890, rs6676671; IL10RA gene: rs2229113, rs3135932; TGF1B gene: rs1800469, rs1800470; each selected on the basis of molecular evidence for functionality, were investigated in this study. Analysis was performed on a group of 621 patients with diagnosis of schizophrenia and 531 healthy controls in Polish population. An association of rs4848306 in IL1B gene, rs4251961 in IL1RN gene, rs2228145 and rs4537545 in IL6R with schizophrenia have been observed. rs6676671 in IL10 was associated with early age of onset. Strong linkage disequilibrium was observed between analyzed polymorphisms in each gene, except of IL10RA. We observed that haplotypes composed of rs4537545 and rs2228145 in IL6R gene were associated with schizophrenia. Analyses with family history of schizophrenia, other psychiatric disorders and alcohol abuse/dependence did not show any positive findings. Further studies on larger groups along with correlation with circulating protein levels are needed.

  7. Episodes of brittle deformation within the Dien Bien Phu Fault zone, Vietnam: Evidence from K-Ar age dating of authigenic illite

    Science.gov (United States)

    Bui, Hoang Bac; Ngo, Xuan Thanh; Khuong, The Hung; Golonka, Jan; Nguyen, Tien Dung; Song, Yungoo; Itaya, Tetsumaru; Yagi, Koshi

    2017-01-01

    Constraining the timing of fault zone origin and movement history is of fundamental geotectonic importance to understand the evolution and processes of the brittle fault structures. The authors present in this paper authigenic illite K-Ar age data from the fault gouge samples, collected from the Dien Bien Phu Fault (DBPF) in the Dien Bien province, Vietnam as well as in a major strike-slip fault zone in South-East Asia; all of which played important roles in the structural formation and geotectonic development of northwestern Vietnam. The gouge fault samples were separated into four grain-size fractions (groups, from 26 to 29 Ma and 130 Ma. The timing of the fault movements is defined at 26 ± 0.24 Ma, 29 ± 0.61 Ma, 130.1 ± 1.27 Ma and 130.7 ± 1.29 Ma. This indicates that the Dien Bien Phu Fault underwent two movements, first in the Early Cretaceous, with an age of about 130 Ma and second in the Oligocene (Paleogene), with an age of about 26-29 Ma. The ductile deformation of the DBPF terminated during the Early Cretaceous. These studies also indicate slow exhumation of the Dien Bien granitoid complex during the Cretaceous times. The Oligocene ages indicate that the DBPF had been reactivated by the SE extrusion and clock-wise rotation of the Indochina block, caused by the collision of the Indian and Eurasian plates. This tectonic event led to the DBPF brittle-sinistral movement, causing the exhumation phase along the fault. This movement period (ca. 26-29 Ma) is coexistent with 600-700 km sinistral shearing along the Red River-Ailao Shan fault. This is the first report determining the absolute age constraints of multi-activated tectonic events, affecting the Dien Bien Phu Fault using the K-Ar dating method for the gouge samples.

  8. Circulating low IL-23: IL-35 cytokine ratio promotes progression associated with poor prognosisin breast cancer.

    Science.gov (United States)

    Chen, Guanghui; Liang, Yanfang; Guan, Xin; Chen, Hui; Liu, Qiankun; Lin, Bihua; Chen, Can; Huang, Mingyuan; Chen, Jianan; Wu, Weiquan; Liang, Yi; Zhou, Keyuan; Zeng, Jincheng

    2016-01-01

    The interleukin (IL)-12 family, composed of heterodimeric cytokines including IL-12 (formed by IL-12p35 and IL-12p40 subunits), IL-23 (formed by IL-23p19 and IL-12p40 subunits), IL-27 (formed by IL-27p28 and EBI3 subunits) and IL-35 (formed by IL-12p35 and EBI3 subunits), establishes a link between innate and adaptive immunity that involves different immune effector cells and cytokines to tumors. However, the role of IL-12 family in breast cancer (BC) progression and prognosis remains unclear. In the present study, we demonstrated evidence indicating that EBI3, IL-12p35 and IL-12p40 but not IL-23p19 or IL-27p28 were highly expressed in BC tissues, suggested that tumor derived EBI3, IL-12p35 and IL-12p40 were associated with tumor progression. Circulating IL-12 and IL-23 low expressed, but IL-27 and IL-35 high expressed in BC patients, especially circulating IL-23 associated with IL-35 to mediate BC tumor resection. Ki-67, p53 and EGFR expression on BC tissues, as well as CA125, CA153 and CA199 levels on BC bloods increased when circulating IL-23: IL-35 ratio decreased. Together, for the first time, our data suggest that circulating IL-23: IL-35 ratio may be an important indicator association with BC progression and prognosis. However, further research should be carried out to assess the implications of circulating IL-23: IL-35 ratio in a larger sample size.

  9. Il Castello di Tomar e il convento di Cristo. La storia ed il tempo presente

    Directory of Open Access Journals (Sweden)

    Alvaro Barbosa

    2008-12-01

    Full Text Available L’insieme monumentale del Castello dei Templari e del Convento di Cristo di Tomar conserva, nei suoi luoghi e nel paesaggio, sette secoli della storia del Portogallo e della cultura europea. Negli ultimi vent’anni i cambiamenti subiti dalla società portoghese si riflettono anche in questo patrimonio storico architettonico: sia la partenza delle istituzioni che lo abitavano dall’inizio del XX secolo, sia il nuovo sguardo della società civile verso il monumento. Tra la storia ed il tempo presente, la vita culturale lì sviluppata in questo periodo ne costituisce la testimonianza. Il nuovo sguardo, sia culturale che scientifico, cerca inoltre di applicare le nuove tecnologie, come l’uso di CAD e della modellazione digitale, nella produzione di strumenti di conservazione e gestione dell’insieme monumentale.

  10. IL-35 and Autoimmunity: a Comprehensive Perspective.

    Science.gov (United States)

    Choi, Jinjung; Leung, Patrick S C; Bowlus, Christopher; Gershwin, M Eric

    2015-12-01

    Interleukin 35 (IL-35) is the most recently identified member of the IL-12 family of cytokines and offers the potential to be a target for new therapies for autoimmune, inflammatory, and infectious diseases. Similar to other members of the IL-12 family including IL-12, IL-23, and IL-27, IL-35 is composed of a heterodimer of α and β chains, which in the case of IL-35 are the p35 and Epstein-Barr virus-induced gene 3 (EBI3) proteins. However, unlike its proinflammatory relatives, IL-35 has immunosuppressive effects that are mediated through regulatory T and B cells. Although there are limited data available regarding the role of IL-35 in human autoimmunity, several murine models of autoimmunity suggest that IL-35 may have potent effects in regulating immunoreactivity via IL-10-dependent mechanisms. We suggest that similar effects are operational in human disease and IL-35-directed therapies hold significant promise. In particular, we emphasize that IL-35 has immunosuppressive ability that are mediated via regulatory T and B cells that are IL-10 dependent. Further, although deletion of IL-35 does not result in spontaneous breach of tolerance, recombinant IL-35 can improve autoimmune responses in several experimental models.

  11. Quantitative Contribution of IL2Rγ to the Dynamic Formation of IL2-IL2R Complexes.

    Directory of Open Access Journals (Sweden)

    Luis F Ponce

    Full Text Available Interleukin-2 (IL2 is a growth factor for several immune cells and its function depends on its binding to IL2Rs in the cell membrane. The most accepted model for the assembling of IL2-IL2R complexes in the cell membrane is the Affinity Conversion Model (ACM. This model postulates that IL2R receptor association is sequential and dependent on ligand binding. Most likely free IL2 binds first to IL2Rα, and then this complex binds to IL2Rβ, and finally to IL2Rγ (γc. However, in previous mathematical models representing this process, the binding of γc has not been taken into account. In this work, the quantitative contribution of the number of IL2Rγ chain to the IL2-IL2R apparent binding affinity and signaling is studied. A mathematical model of the affinity conversion process including the γ chain in the dynamic, has been formulated. The model was calibrated by fitting it to experimental data, specifically, Scatchard plots obtained using human cell lines. This paper demonstrates how the model correctly explains available experimental observations. It was estimated, for the first time, the value of the kinetic coefficients of IL2-IL2R complexes interaction in the cell membrane. Moreover, the number of IL2R components in different cell lines was also estimated. It was obtained a variable distribution in the number of IL2R components depending on the cell type and the activation state. Of most significance, the study predicts that not only the number of IL2Rα and IL2Rβ, but also the number of γc determine the capacity of the cell to capture and retain IL2 in signalling complexes. Moreover, it is also showed that different cells might use different pathways to bind IL2 as consequence of its IL2R components distribution in the membrane.

  12. Manipulación mediática, identidad juvenil y prostitución de un bien necesario

    Directory of Open Access Journals (Sweden)

    Alexander Mosquera

    2007-01-01

    Full Text Available Algo que identifi ca al joven de hoy es la telefonía móvil, una nueva tecnología que invade todas las esferas de lavida pública y privada, cuya presencia se hace sentir a través de una multiplicidad de “ring-tones”. Este trabajo tienecomo objetivo general describir la interrelación que se da entre la manipulación de los medios a través del discursopublicitario sobre celulares, la construcción de la identidad juvenil y la prostitución de lo que otrora fuera un bien necesariocomo el teléfono. Se abordó un corpus compuesto por varios avisos publicitarios que circularon en los diariosvenezolanos El Nacional, La Verdad y Panorama durante agosto de 2005, desde la perspectiva teórico-metodológicade la semiótica crítica de González de Ávila y de la semiótica de la cultura de Lotman. También se utilizaron algunosaportes de Magariños de Morentin relacionados con la semiótica de los mensajes publicitarios, así como los de Caro Almela, Bourdieu, Pasquali y Eco sobre los mass-media. Los resultados revelaron una manipulación mediática a través del discurso publicitario, dirigida a crear la urgente necesidad de poseer un celular, porque éste es el signo-mercancía con el cual se identifi ca el joven actual. Una conclusión preliminar indica que la no-posesión de ese aparato hace aparecer al joven como un “excluido” de ese mundo de la telefonía móvil.

  13. Modelo para la inflación básica de bienes transables y no transables en Colombia

    Directory of Open Access Journals (Sweden)

    José Luis Torres Trespalacios

    2015-12-01

    Full Text Available En este trabajo se estiman modelos de corto plazo para pronosticar la inflación de bienes transables y no transables en Colombia. Estos modelos no existían en el Banco Central antes de 2004 y son de gran utilidad para la toma de decisiones de política monetaria. También se evalúan los beneficios, en términos de análisis y de capacidad pronóstico, de utilizar métodos que capturen la posible no linealidad de la curva de Phillips en los datos colombianos. Aunque existen diferentes razones que justifican una relación no lineal de corto plazo entre producto e inflación, cada una de ellas sugiere una forma diferente para la curva. Por esta razón, se utilizan redes neuronales artificiales (ANN y los mínimos cuadrados flexibles (FLS, procedimientos que tienen la gran ventaja de que no imponen de antemano ninguna forma funcional que pueda sesgar los resultados. Una vez se hace la estimación de los modelos de inflación de transables y de no transables, se comparan los pronósticos de estos dos modelos no lineales con los de dos estimaciones lineales , se analizan las funciones de impulso respuesta de cada uno de los modelos y además se realiza una prueba de no linealidad. Se encuentra que la curva de Phillips en Colombia podria ser no lineal y por tanto, resulta pertinente considerar modelos no lineales para su estimación. Finalmente, con estos modelos se intenta explicar el proceso de desinflación que ha vivido la economía colombiana en los últimos años tanto en la inflación de transables, como en la de no transables.

  14. IL-3、IL-5及IL-8与鼻息肉的关系研究%Relationship study between IL-3,IL-5 and IL-8 and Nasal polypus

    Institute of Scientific and Technical Information of China (English)

    赵雯

    2010-01-01

    Objective To explore the role of IL-3,IL-5 and IL-8 in the genesis and development of nasal polypus(NP) by testing IL-3 ,IL-5 and IL-8 Value in Nasal polypus issue. Methods 50 cases of nasal polyps and 30 casesof normal middle turbinate mucosa were involved in this study. Concentrations of IL-3, IL-5 and IL-8 were determined by enzyme linked immunosorbent assay(ELISA). Results The levels of IL-3 ,IL-5 and IL-8 in Nasal polypus issue were significantly higher than that in control group( P < 0.05 ). Conclusion The levels of IL-3, IL-5 and IL-8 in Nasal polypus issue rised,They likely played a certain role in the genesis and development of NP.%目的 检测鼻息肉组织中白细胞介素-3(IL-3)、白细胞介素-5(IL-5)和白细胞介素-8(IL-8)的含量,探讨细胞因子在鼻息肉形成中的作用.方法 标本取自50例鼻息肉患者的息肉组织(研究组)和30例行鼻中隔手术患者的正常下鼻甲黏膜(对照组),用酶联免疫吸附测定(ELISA)法检测IL-3、IL-5和IL-8在鼻息肉标本和正常下鼻甲黏膜的含量.结果 鼻息肉组织IL-3、IL-5和IL,-8的水平明显高于对照组,两组间差异有统计学意义(P<0.05).结论 IL,-3、IL-5和IL-8在鼻息肉组织中明显升高,提示其可能与鼻息肉的发病机制有关.

  15. IL-28 and IL-29: newcomers to the interferon family.

    Science.gov (United States)

    Uzé, Gilles; Monneron, Danièle

    2007-01-01

    IL-28 and IL-29 were recently described as members of a new cytokine family that shares with type I interferon (IFN) the same Jak/Stat signalling pathway driving expression of a common set of genes. Accordingly, they have been named IFN lambda. IFNs lambda exhibit several common features with type I IFNs: antiviral activity, antiproliferative activity and in vivo antitumour activity. Importantly, however, IFNs lambda bind to a distinct membrane receptor, composed of IFNLR1 and IL10R2. This specific receptor usage suggests that this cytokine family does not merely replicate the type I IFN system and justifies its designation as type III IFN by the nomenclature committee of the International Society of Interferon and Cytokine Research.

  16. Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's syndrome.

    Science.gov (United States)

    Kyriakidis, Ioannis; Samara, Pinelopi; Papa, Anna

    2011-05-01

    Studies on cytokine levels in Weil's syndrome are lacking. In this study, TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels were measured in 44 serum samples of patients diagnosed with Leptospira interrogans serovar icterohaemorrhagiae infection. TNF-α levels linked with pulmonary hemorrhagic implications, while elevated sTNFR1 and IL-10 levels linked with fatal cases. IL-6 and IL-8 did not seem to affect the outcome of the disease. Immune response pattern in Weil's syndrome bears resemblance to other patterns described for hemorrhagic fevers. IL-10/TNF-α ratio is proposed as a marker for prognosis.

  17. Les grands problèmes mathématiques ils orientent l'avenir des maths

    CERN Document Server

    2012-01-01

    Les mathématiques ont leurs sept merveilles ! Il s’agit des sept problèmes du millénaire, mis à prix à un million de dollars chacun par l’Institut Clay de mathématiques en 2000. Mais l’intelligence des mathématiciens est aussi mise à l’épreuve par bien d’autres problèmes, tels ceux de Hilbert. Découvrez dans ce numéro comment ces énigmes orientent l’avenir de la discipline ouvrant la voie à de nouvelles connaissances fondamentales.

  18. Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones.

    NARCIS (Netherlands)

    Bayley, J.P.; Bakker, AM; Kaijzel, EL; Wierenga, EA; Pouw Kraan, van der C.T.M.; Huizinga, T.W.; Verweij, C.L.

    2003-01-01

    The occurrence of monoallelic expression of cytokine genes in single cells has been convincingly demonstrated, but there have been few reports of this phenomenon in T cell clones. Here we describe studies on the expression of alleles of the human genes encoding IL-2, IL-3, IL-4, and IL-13 in human C

  19. Il potere di Prometeo e il dovere di Kant

    Directory of Open Access Journals (Sweden)

    Stefano Picchetti

    2006-10-01

    Full Text Available Kant ci suggerisce qualcosa che Prometeo e il mito greco avevano già accennato. L'imperativo che pone freno al fare, è già in sé nel soggetto ed è per questo che egli che egli è responsabile delle proprie azioni, indipendentemente dalla legge scritta.

  20. Il Sole, il genoma e Internet strumenti delle revoluzioni scientifiche

    CERN Document Server

    Dyson, Freeman J

    2000-01-01

    In queste appassionate conferenze «di soglia» Dyson si sporge sul domani con la visionarietà di un Verne o di un Wells, consapevole però di abbozzare «solo uno dei corsi possibili, tra i milioni di altri che il futuro potrà riservarci». Il nuovo trivio di forze rivoluzionarie che, secondo il modello di Dyson, muoverà lo sviluppo ha nomi noti a tutti, e disputati da molti: energia solare, ingegneria genetica, rete di comunicazione globale. Un loro utilizzo flessibile e sinergico arriverebbe a ridisegnare il paesaggio sociale del pianeta, facendo affluire verso aree depresse risorse ora concentrate in pochi paesi, e ridando vita ovunque all'economia di villaggio. La raccolta di energia da una fonte equidistribuita come la luce solare potrebbe infatti avvenire attraverso coltivazioni arboree manipolate genetica mente allo scopo, con costi sostenibili e senza pregiudizio della ecodiversità. Sia che guardi al prossimo futuro terrestre sia che contempli la prospettiva non troppo lontana di insediamenti uma...

  1. Il programma dell'universo

    CERN Document Server

    Lloyd, Seth

    2006-01-01

    Da quando l'universo ha avuto inizio, ha cominciato a calcolare il proprio comportamento. All'inizio il computer-universo produceva strutture semplici, particelle elementari e leggi elementari della fisica; col passare del tempo ha processato "informazioni" sempre più complesse, producendo strutture sempre più intricate (galassie, stelle, pianeti), ma sempre secondo leggi semplici. Ogni cosa deve quindi la propria esistenza alla capacità intrinseca della materia e dell'energia di processare informazione. Se si decifrasse fino in fondo si potrebbe, con un computer quantistico di dimensioni ridotte, comprendere l'universo nel suo insieme.

  2. Il Dio dell'Eriugena

    Directory of Open Access Journals (Sweden)

    Silvia Magnavacca

    2008-07-01

    Full Text Available In un universo interpretato come sogno da decifrare, la metafisica è lo strumento, secondo Borges, con cui l’uomo tenta di rendere coerente questo sogno. Il pensiero di Eriugena è particolarmente affascinante per Borges, in quanto accetta la sfida della veritigine: un Dio che dal nulla della sua indeterminatezza dà luogo al mondo, dispiegandosi negli archetipi che popolano il sogno dell’universo. Una fantastica metafisica che allontana dall’uomo lo sgomento per la condanna alla propria individualità.

  3. 尖锐湿疣组织IL-2、IL-4、IL-1O、IL-18的表达

    Institute of Scientific and Technical Information of China (English)

    胡凯; 程方雄; 陈蓓; 韩林; 马鸣

    2012-01-01

    目的:探讨尖锐湿疣(CA)患者治疗前、后血清中白介素2(IL-2)、白介素4(IL-4)、白介素10(IL-10)和白介素18(IL-18)的水平变化在CA免疫发病机制中的作用.方法:用酶联免疫吸附法(ELISA)分别检测30例CA患者在治疗前和治疗后3个月未复发时血清IL-2、IL-4、IL-10和IL-18的水平,并与20例正常人作比较.结果:CA患者治疗前血清中IL2水平明显低于正常对照组(P>0.01),IL-4、IL-10和IL-18水平明显高于正常对照组(P>0.05);治疗后3个月末血清IL-2、IL-4、IL-10、IL-18的水平同正常对照组相比,差异无统计学意义(P均>0.05).结论:人乳头瘤病毒(HPV)感染可造成患者细胞免疫功能异常,IL2、IL-4、IL-10和IL-18在CA免疫发病机制中可能起重要作用.

  4. La economía social y solidaria como alternativa económica. Bienes comunes y democracia

    Directory of Open Access Journals (Sweden)

    Jaime Abad Montesinos

    2014-10-01

    Full Text Available Normal 0 21 MicrosoftInternetExplorer4 Resumen: El presente artículo trata de enmarcar la economía social y solidaria en el seno del actual debate producto de la crisis económica vigente, haciendo especial hincapié en las cuestiones relacionadas con los bienes comunes y la gestión democrática. La crisis presente ha puesto de manifiesto la necesidad de proponer modelos socio-económicos alternativos que aúnen democracia, compromiso social y sostenibilidad del medio ambiente. La economía social y solidaria, sin ser un programa homogéneo, está contribuyendo a proponer respuestas a algunos de los problemas actuales en materia de desempleo e integración social, revalorizando en los procesos económicos, no sólo los intercambios mercantiles, sino también los intereses sociales y los recursos naturales. Abstract:This article aims to enlighten the importance ofsolidary and social economy in the present discussion, whose importance has increased as a result of the current economic crisis, making a special emphasis on subjects such as commons goods and democratic management. The crisis has brought up the need for alternative socio-economical management models which must combine democracy, social commitment and environmental sustainability. Solidary and social economy, without being a homogeneous program, are proposing answers to some of the present problems related to unemployment and social integration, contributing to increase the value of economic processes, not only in commercial exchanges, but also the social interest and natural resources. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman";} /* Style Definitions */ table.MsoNormalTable {mso

  5. Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2

    OpenAIRE

    Wood, Nancy; Whitters, Matthew J.; Jacobson, Bruce A; Witek, JoAnn; Sypek, Joseph P; Kasaian, Marion; Eppihimer, Michael J.; Unger, Michelle; Tanaka, Takashi; Goldman, Samuel J; Collins, Mary; Donaldson, Debra D.; Grusby, Michael J.

    2003-01-01

    Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R)α and IL-13Rα1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13Rα2, whose function in IL-13 signaling is unknown. To better appreciate the functional importance of IL-13Rα2, mice deficient in IL-13Rα2 were generated by gene targeting. ...

  6. Prolegómenos al vivir bien-buen vivir: una evaluación normativa y práctica

    Directory of Open Access Journals (Sweden)

    Edwin Cruz Rodríguez

    2015-06-01

    Full Text Available Este trabajo examina el concepto de vivir bien-buen vivir ponderando sus contribuciones y limitaciones. Esta cosmovisión tiene un horizonte normativo más ambicioso que el paradigma del desarrollo, pues apuesta por una concepción de la pobreza y la riqueza que no se reduce a la acumulación de bienes materiales, una economía que comprende sus efectos sobre la naturaleza y se centra en la satisfacción de necesidades, y una descolonización de los saberes. No obstante, se caracteriza por un déficit de operacionalización que se manifiesta en la dificultad para definir políticas concretas e indicadores de medición precisos.

  7. Palpitando la modernidad: el negocio de bienes raíces en Cali (Colombia a partir del caso de Jorge Garcés Borrero, 1900-1944

    Directory of Open Access Journals (Sweden)

    María Fernanda Erazo Obando

    2014-01-01

    Full Text Available El objetivo del presente artículo es analizar el movimiento de compra y venta de bienes raíces en Cali (Colombia durante la primera mitad del siglo XX. Para ello, se toma como referencia la empresa del comerciante Jorge Garcés Borrero, la cual, se enfocó principalmente en la ejecución de este tipo de negocios. Dicha empresa, a pesar de no haberse constituido legal y jurídicamente, presentó las características de una compañía como tal, generando importantes inversiones y ganancias a partir del mercado de bienes. Apoyados en fuentes notariales se explica el desarrollo de esta actividad comercial entre 1900-1944.

  8. Hacia una economía más humana: Tecnología en bienes vitales para reducir el costo de vida

    Directory of Open Access Journals (Sweden)

    Guillermo Runciman Saettone

    2014-11-01

    Full Text Available El presente estudio representa un ensayo que tiene como objetivo proponer lineamientos aplicables a la economía peruana para incrementar la productividad en la elaboración de los bienes vitales (agua segura, alimentos nutritivos, abrigo y techo y los servicios asociados a ellos. A juicio de los autores, estos son los bienes indispensables para emprender cualquier proyecto de vida del ser humano. En la aplicación, se presentan ejemplos de proyectos que permitirían lograr el objetivo en el Perú. Para ello, se toman en consideración aspectos geográficos determinantes; el desarrollo de la infraestructura de energía, transporte y sistemas hídricos; y la propuesta de un plan de desarrollo a nivel macroregional.

  9. “Jeneros de gusto y sobretodos ingleses”: el impacto cultural del consumo de bienes ingleses por la clase alta bogotana .

    Directory of Open Access Journals (Sweden)

    Ana Maria Otero Cleves.

    2009-05-01

    Full Text Available Este artículo analiza el impacto cultural del consumo de bienes Inglés por la clase alta de Bogotá durante el siglo XIX. Se sugiere que el consumo de productos Inglés después de la independencia del país fue uno de los principales mecanismos empleados por las clases altas para asegurar su posición social, así como para construir una nación moderna, de acuerdo a las normas europeas. Por lo tanto, el artículo analiza el papel que el consumo de bienes extranjeros en el proceso de construcción de la nación y la diferenciación social en el siglo XIX.

  10. Negros y pardos propietarios de bienes raíces y de esclavos en el Buenos Aires de fines del período hispánico

    Directory of Open Access Journals (Sweden)

    Rosal, Miguel A.

    2001-12-01

    Full Text Available El trabajo pretende ilustrar un aspecto poco conocido dentro de la problemática afroporteña; nos referimos a la capacidad para adquirir bienes inmuebles —terrenos y casas— y esclavos que tenían los integrantes de la raza africana, en general de condición libre, pero también esclavizados, en el Buenos Aires tardocolonial, capacidad fundada sin duda en una significativa actividad laboral y, en especial, artesanal. En ese sentido, hacemos referencia a las características de los inmuebles, a los precios de los mismos, a su ubicación en el espacio urbano (distribución de los afroporteños según los barrios y, por último, a la participación de negros y blancos en el mercado porteño de compraventa de bienes raíces y de esclavos.

  11. Palpitando la modernidad: el negocio de bienes raíces en Cali (Colombia a partir del caso de Jorge Garcés Borrero, 1900-1944

    Directory of Open Access Journals (Sweden)

    María Fernanda Erazo Obando

    2014-07-01

    Full Text Available El objetivo del presente artículo es analizar el movimiento de compra y venta de bienes raíces en Cali (Colombia durante la primera mitad del siglo XX. Para ello, se toma como referencia la empresa del comerciante Jorge Garcés Borrero, la cual, se enfocó principalmente en la ejecución de este tipo de negocios. Dicha empresa, a pesar de no haberse constituido legal y jurídicamente, presentó las características de una compañía como tal, generando importantes inversiones y ganancias a partir del mercado de bienes. Apoyados en fuentes notariales se explica el desarrollo de esta actividad comercial entre 1900-1944.

  12. IL-17/Th17 mediated synovial inflammation is IL-22 independent

    NARCIS (Netherlands)

    J.P. van Hamburg (Jan Piet); O.B.J. Corneth (Odilia); S.M.J. Paulissen (Sandra); N. Davelaar (Nadine); P. Asmawidjaja (Patrick); A.M.C. Mus (Adriana); E.W. Lubberts (Erik)

    2013-01-01

    markdownabstractABSTRACT Background: Interleukin (IL)-17A and Th17 cells are critically involved in T cell-mediated synovial inflammation. Besides IL-17A, Th17 cells produce IL-22. Recently, Th22 cells were discovered, which produce IL- 22 in the absence of IL-17. However, it remains

  13. Role of IL-1alpha and IL-1beta in ischemic brain damage.

    Science.gov (United States)

    Boutin, H; LeFeuvre, R A; Horai, R; Asano, M; Iwakura, Y; Rothwell, N J

    2001-08-01

    The cytokine interleukin-1 (IL-1) has been strongly implicated in the pathogenesis of ischemic brain damage. Evidence to date suggests that the major form of IL-1 contributing to ischemic injury is IL-1beta rather than IL-1alpha, but this has not been tested directly. The objective of the present study was to compare the effects of transient cerebral ischemia [30 min middle cerebral artery occlusion (MCAO)] on neuronal injury in wild-type (WT) mice and in IL-1alpha, IL-1beta, or both IL-1alpha and IL-1beta knock-out (KO) mice. Mice lacking both forms of IL-1 exhibited dramatically reduced ischemic infarct volumes compared with wild type (total volume, 70%; cortex, 87% reduction). Ischemic damage compared with WT mice was not significantly altered in mice lacking either IL-1alpha or IL-1beta alone. IL-1beta mRNA, but not IL-1alpha or the IL-1 type 1 receptor, was strongly induced by MCAO in WT and IL-1alpha KO mice. Administration (intracerebroventricularly) of recombinant IL-1 receptor antagonist significantly reduced infarct volume in WT (-32%) and IL-1alpha KO (-48%) mice, but had no effect on injury in IL-1beta or IL-1alpha/beta KO mice. These data confirm that IL-1 plays a major role in ischemic brain injury. They also show that chronic deletion of IL-1alpha or IL-1beta fails to influence brain damage, probably because of compensatory changes in the IL-1 system in IL-1alpha KO mice and changes in IL-1-independent mediators of neuronal death in IL-1beta KO mice.

  14. Los bienes humanos básicos y la fundamentación del derecho. Un estudio de la propuesta de john finnis Basic Human Goods and the

    Directory of Open Access Journals (Sweden)

    Marina Dandois

    2014-01-01

    Full Text Available Este trabajo busca dilucidar en qué medida la explicación sobre los bienes humanos básicos ofrecida por el iusfilósofo australiano John Finnis puede ser de utilidad para dar cuenta del fenómeno jurídico actual. Ello así, dada la incorporación en la mayoría de los textos constitucionales ocidentales de derechos fundamentales —en muchos casos recogidos como principios— y de sistemas de control de constitucionalidad, que supone reconocer, entre otras cosas, que los sistemas jurídicos no solo están formados por reglas, sino también por principios capaces de dirigir la acción como Derecho directamente aplicable y que la validez de las reglas del sistema depende no sólo de su corrección formal, sino también de su compatibilidad con los derechos fundamentales recogidos constitucionalmente. Para ello, en primer lugar se desarrollará la noción de bienes humanos básicos y los caracteres que aquellos comparten – autoevidentes, pre-morales y fundamentales. Luego se tendrán en cuenta los diversos desafíos que pueden planteárseles a los bienes humanos básicos en lo que respecta a ser todos ellos igualmente autoevidentes, pre-morales y fundamentales, y se sugerirán posibles respuestas a dichas objeciones. De este estudio se arribará a una conclusión sobre la idoneidad de los bienes humanos básicos para constituir puntos de partida irreductibles, inderivables y directivos, que permitan formular el conjunto de estándares morales generales de los que se nutren los principios constitucionales.

  15. Fuentes de información para el diseño de un Sistema de Vigilancia e Inteligencia en el Registro Provincial de Bienes Culturales de Matanzas

    Directory of Open Access Journals (Sweden)

    Justa Bielka Cantillo González

    2007-01-01

    Full Text Available Por la importancia que reviste la conservación del Patrimonio Cultural, se identifican, con la utilización de herramientas estadísticas (Coeficiente de Concordancia de Kendall las fuentes de información relevantes, para el posterior diseño de un Sistema de Vigilancia e Inteligencia en el Registro Provincial de Bienes Culturales de la provincia de Matanzas

  16. 尖锐湿疣组织IL-2、IL-4、IL-10、IL-18表达的意义

    Institute of Scientific and Technical Information of China (English)

    胡凯; 程方雄; 陈蓓; 韩林; 马鸣

    2012-01-01

    目的:探讨尖锐湿疣(CA)患者治疗前、后血清中白细胞介素(IL)-2、IL-4、IL-10和IL-18的水平变化在CA免疫发病机制中的作用.方法:用酶联免疫吸附法(ELISA)分别检测30例CA患者在治疗前和治疗后3个月未复发时血清IL-2、IL-4 、ID-10和IL-18的水平,并与20例正常人作比较.结果:结果CA患者治疗前血清中IL-2水平明显低于正常对照组(P<0.01),IL-4、IL-10和IL-18水平明显高于正常对照组(P<0.05);治疗后3个月末血清IL-2、IL-4、IL-10、IL-18的水平同正常对照组相比,差异无统计学意义(均P>0.05).结论:人乳头瘤病毒(HPV)感染可造成患者细胞免疫功能异常,IL-2、IL-4、IL-10和IL 18在CA免疫发病机制中可能起重要作用.

  17. La América Latina y El Caribe en 1913 y 1925. Enfoque desde las importaciones de bienes de capital

    Directory of Open Access Journals (Sweden)

    Xavier Tafunell

    2008-01-01

    Full Text Available En este artículo estudiamos el desarrollo económico alcanzado por la totalidad de los Estados latinoamericanos y caribeños soberanos en 1913 y 1925 desde una perspectiva inédita en el estudio del conjunto de la región: las importaciones y la producción –que sumadas equivalen al consumo aparente– de bienes de capital. Asegurada la fiabilidad de las estadísticas del comercio exterior, procedemos a reconstruir las magnitudes de los bienes de capital adquiridos por las 20 repúblicas. También estimamos la producción interna. La nueva evidencia empírica pone de manifiesto las enormes diferencias existentes en el seno de la región en el consumo per cápita de bienes de capital al término de la primera oleada globalizadora. La comparación entre los niveles de 1913 y 1925 revela que, en general, la contienda mundial no favoreció el proceso de sustitución de importaciones de la región, pero no en todos los países por igual.

  18. El dominio público y los bienes públicos: Europa y América Latina. ¿El hijo sigue mirando al padre?

    Directory of Open Access Journals (Sweden)

    Sergio Chemás

    2015-12-01

    Full Text Available El estudio del derecho de los bienes públicos en América Latina y en Colombia es algo todavía poco desarrollado. Se sigue mirando hacia el derecho comparado para obtener respuestas, tal como un hijo mira a su padre, porque fue allá donde surgieron los grandes desarrollos del tema. El dominio público en Europa y América Latina es producto de un encuentro entre varias autoridades en el tema de los bienes públicos tanto de Europa como de América Latina. Esta reseña se divide en tres partes: i un breve análisis de derecho comparado frente al concepto de dominio público; ii la identificación de los contenidos más interesantes e innovadores de los regímenes de bienes públicos, y iii un ejercicio académico para que el lector lo desarrolle al leer el libro.

  19. Role of IL-38 and Its Related Cytokines in Inflammation

    Directory of Open Access Journals (Sweden)

    Xianli Yuan

    2015-01-01

    Full Text Available Interleukin- (IL- 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.

  20. IL-8、IL-17以及IL-18与胃癌的关系

    Institute of Scientific and Technical Information of China (English)

    林丹; 杜苗苗; 杜季梅

    2012-01-01

    胃癌是危害人类健康最常见的恶性肿瘤之一,其病死率仅次于肺癌,位居癌症死亡第2位。多项研究表明白细胞介素(interleukin,IL)IL-8、IL-17及IL-18,与胃癌的发生发展有着密切的联系。该文对IL-8、IL-17和IL-18与肿瘤和胃癌关系作一简要概述。

  1. IL-13 working through IL-13Ra1 mediates critical functional responses to nematode infection in the gastrointestinal tract

    Science.gov (United States)

    Nematode infection up-regulates IL-4 and IL-13 and induces STAT6-dependent changes in epithelial function and smooth muscle contractility that promote worm clearance. IL-4 and IL-13 share the same type II IL-4R that contains the IL-13R'1 and the IL-4R' chain linked to STAT6. The role of IL-13 workin...

  2. 热化疗治疗非小细胞肺癌对IL-2、IL-6、IL-8、IL-10及TNF的影响%Effect of thermochemotherapy on levels of IL-2 ,IL-6 ,IL-8 ,IL-10 and TNF in non-small cell lung cancer

    Institute of Scientific and Technical Information of China (English)

    李新民; 尉继伟; 刘治邦; 刘建国

    2014-01-01

    目的 探讨热化疗治疗非小细胞肺癌(NSCLC)对白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)及肿瘤坏死因子(TNF)的影响.方法 回顾性分析大同大学附属医院2004年10月至2013年1月收治的134例NSCLC患者,进行热疗联合NP方案化疗(NVB+ DDP),并分别在治疗前、治疗3个周期后、治疗6个周期后、治疗结束后3个月对患者血清中IL-2、IL-6、IL-8、IL-10及TNF的变化进行监测.结果 热化疗3个周期后,IL-2、TNF水平逐渐增高,明显高于治疗前;IL-6、IL-8和IL-10水平明显低于化疗前.热化疗6个周期后,血IL-6、IL-8、IL-10、IL-2和TNF都有所下降,其中IL-2、TNF浓度显著低于化疗3个周期后的水平.热化疗结束后3个月,血IL-6、IL-8、IL-10水平继续下降;而IL-2、TNF浓度逐渐增高,低于化疗3个周期后的水平,但高于治疗前水平.结论 热化疗治疗NSCLC对IL-2、TNF水平有明显的增高作用,而对IL-6、IL-8、IL-10有降低作用.%Objective To investigate the effect of hot therapy on interleukin-2 (IL-2),interleukin-6 (IL-6),interlerukin-8 (IL-8),interleukin-10 (IL-10) and tumor necrosis factor (TNF) in nonsmall cell lung cancer(NSCLC).Methods One hundred and thirty-four patients with NSCLC,admitted to our hospital from October 2004 to January 2013,received hot therapy and vinorelbine plus cisplatin (NP) chemotherapy.The IL-6,IL-8,IL-10 and TNF level before therapy,after 3 cycles,after 6 cycles and 3 months after chemotherapy were observed.Results IL-2 and TNF levels increased gradually after 3 cycles of hot therapy,and were significant higher than those before therapy.Compared to before therapy,IL-6,IL-8 and IL-10 levels significantly decreased.IL-6,IL-8,IL-10,IL-2 and TNF levels all decreased at 6 months after hot therapy.IL-2 and TNF levels were significant lowered than those of 3 cycles after chemotherapy.IL-6,IL-8 and IL-10 continued to decrease 3 months after the end of

  3. 哮喘患儿血清中sIL-2R,IL-2,IL-4,IL-13的测定与临床意义

    Institute of Scientific and Technical Information of China (English)

    张国祥; 许文龙

    2007-01-01

    目的 探讨哮喘患儿血清中sIL-2R,IL-2,IL-4,IL-13的水平变化及其与哮喘发病机制的关系.方法 每例患儿及正常对照组均取空腹静脉血并即时分离血清1 ml,用ELISA法检测血清中sIL-2R,IL-2,IL-4,IL-13的水平,并对检测结果 进行医学统计学分析处理.结果 哮喘急性发作组、哮喘缓解组的患儿血清中sIL-2R,IL-2,IL-4,IL-13的测定结果与正常对照组相比较经统计学分析均存在极其显著的差异(P<0.05).其中患儿哮喘急性发作组、哮喘缓解组血清中sIL-2R,IL-4,IL-13的测定结果 要明显高于正常对照组,而IL-2则明显低于正常对照组.此外,哮喘急性发作组与哮喘缓解组血清中IL-2,IL-4,IL-13的测定结果 相比较经统计学分析均存在显著的差异(P<0.05),而sIL-2R则无显著差异.结论 哮喘患儿血清中sIL-2R,IL-2,IL-4,IL-13的水平均存在显著的变化,说明它们在哮喘的发病机制中起着重要的作用.

  4. IL RAY-TRACING NELLA IONOSFERA

    OpenAIRE

    Azzarone, A.; Bianchi, C.; Settimi, A

    2010-01-01

    Il pacchetto applicativo “IONORT” per il calcolo del ray-tracing può essere utilizzato dagli utenti che impiegano il sistema operativo Windows. È un programma la cui interfaccia grafica con l’utente è realizzata in MATLAB. In realtà, il programma lancia un eseguibile che integra il sistema d’equazioni differenziali scritto in linguaggio Fortran e ne importa l’output nel programma MATLAB, il quale genera i grafici e altre informazioni sul raggio. A completamento di questa premessa va detto che...

  5. IL-2 and IL-15 Exhibit Opposing Effects on Fas Mediated Apoptosis

    Institute of Scientific and Technical Information of China (English)

    Gulcin Demirci; Xian Chang Li

    2004-01-01

    It has been shown that IL-2 and IL-15 can have opposing effects on life and death of T cells. However, the role of IL-2 and IL-15 in regulating the fate of other cell types is less clear. In the present study, we examined the impact of IL-2 and IL-15 on life and death of pre-B cells using the BAF-B03 line. We showed that BAF-B03 cells constitutively expressed the private IL-2Rα chain and IL-15Rα chain, and the shared IL-2Rβ chain and γc chain. Stimulation of BAF-B03 cells in vitro with IL-2 and IL-15 induced vigorous cell proliferation in a dose-dependent fashion. Titration of IL-2 and IL-15 in the assay showed that the mitotic effects of IL-2 and IL-15 were remarkably similar, Howerer, the sensitivities of BAF-B03 cells to Fas mediated apoptosis after IL-2 and IL-15 stimulation were strikingly different. Cells cultured in IL-2 readily underwent apoptotic cell deathupon cross-linking of the Fas receptor whereas cells cultured in IL-15 were extremely resistant to Fas triggered cell death. The anti-apoptotic effect of IL-15 in this model was associated with increased expression of Bcl-xL. FLIP expression, however, was comparable between IL-2 and IL-15 stimulated cells. We conclude that IL-2 and IL-15 have diametrically opposite effect on the fate of BAF-B03 cells, although both cytokines share similar receptor structure and exhibitsimilarmitoticactivities.

  6. IL-2 and IL-15 Exhibit Opposing Effects on Fas Mediated Apoptosis

    Institute of Scientific and Technical Information of China (English)

    GulcinDemirci; XianChangLi

    2004-01-01

    It has been shown that IL-2 and IL-15 can have opposing effects on life and death of T cells. However, the roie of IL-2 and IL-15 in regulating the fate of other cell types is less clear. In the present study, we examined the impact of IL-2 and IL-15 on life and death of pre-B cells using the BAF-B03 line. We showed that BAF-B03 cells constitutively expressed the private IL-2Rα chain and IL-15Rα chain, and the shared IL-2Rβ chain and γc hain. Stimulation of BAF-B03 cells in vitro with IL-2 and IL-15 induced vigorous cell proliferation in a dose-dependent fashion. Titration of IL-2 and IL-15 in the assay showed that the mitotic effects of IL-2 and IL-15 were remarkably similar. However, the sensitivities of BAF-B03 cells to Fas mediated apoptosis after IL-2 and IL-15 stimulation were strikingly different. Cells cultured in IL-2 readily underwent apoptotic cell death upon cross-linking of the Fas receptor whereas cells cultured in IL-15 were extremely resistant to Fas triggered cell death. The anti-apoptotic effect of IL-15 in this model was associated with increased expression of Bcl-xL. FLIP expression, however, was comparable between IL-2 and IL-15 stimulated cells. We conclude that IL-2 and IL-15 have diametrically opposite effect on the fate of BAF-B03 cells, although both cytokines share similar receptor structure and exhibit similar mitotic activities. Cellular & Molecular Immunology. 2004;1(2):123-128.

  7. Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer

    Directory of Open Access Journals (Sweden)

    Bachmann Alexander

    2011-09-01

    Full Text Available Abstract Background Chronic inflammation has been suggested to favour prostate cancer (PCA development. Interleukins (IL represent essential inflammation mediators. IL-2, IL-7, IL-15 and IL-21, sharing a common receptor γ chain (c-γ, control T lymphocyte homeostasis and proliferation and play major roles in regulating cancer-immune system interactions. We evaluated local IL-2, IL-7, IL-15 and IL-21 gene expression in prostate tissues from patients with early stage PCA or benign prostatic hyperplasia (BPH. As control, we used IL-6 gene, encoding an IL involved in PCA progression. IL-6, IL-7 and IL-15 titres were also measured in patients' sera. Methods Eighty patients with BPH and 79 with early (1 to 2c stage PCA were enrolled. Gene expression in prostate tissues was analyzed by quantitative real-time PCR (qRT-PCR. Serum IL concentrations and acute phase protein titres were evaluated by ELISA. Mann-Whitney, Wilcoxon and χ2 tests were used to compare IL gene expression and serum titers in the two groups of patients. Receiver operating characteristic (ROC curves were constructed to evaluate the possibility to distinguish sera from different groups of patients based on IL titers. Results IL-2 and IL-21 gene expression was comparably detectable, with low frequency and at low extents, in PCA and BPH tissues. In contrast, IL-6, IL-7 and IL-15 genes were expressed more frequently (p Conclusions Expression IL-7 and IL-15 genes in prostate tissues and corresponding serum titres are significantly increased in patients with early stage PCA as compared with patients with BPH.

  8. The role of IL-4 and IL-13 in cutaneous Leishmaniasis.

    Science.gov (United States)

    Hurdayal, Ramona; Brombacher, Frank

    2014-10-01

    Murine models of Leishmania major infection in the 1980s revealed two distinct, counter-regulatory populations of CD4(+) T helper (Th) cells, delineated Th1 and Th2, and their archetypal cytokines, interferon gamma (IFN-γ) and interleukin (IL)-4/IL-13, which promoted resistance/susceptibility to infection, respectively. However, the introduction of global cytokine-deficient mice in the 1990s revealed pleiotropic immune-regulatory mechanisms of IL-4 and IL-13 that either controlled or exacerbated disease. This undermined the basic premise that IL-4/IL-13 played paramount roles in facilitating a non-healing Th2 response to Leishmania infection and instead suggested that both IL-4 and IL-13-dependent and IL-4/IL-13-independent factors orchestrate disease outcome. The recent characterization of cell-type specific IL-4Rα deficient mice was initiated to help reconcile these observations and dissect the cell-specific effects of IL-4/IL-13 during infection. In this review, we summarize original and recent findings with regard to the role of IL-4 and IL-13 in cutaneous Leishmaniasis. Using the information discerned from various studies and our conditional IL-4Rα gene-deficient mice, we particularly discuss the double-edged sword IL-4 (and in some Leishmania disease models IL-13) in driving a susceptible Th2 response, their immune cell targets that support healing or non-healing responses and their novel role in mediating a Th1 response during disease.

  9. 126Gln is the residue of human IL-2 binding to IL-2R γ subunit

    Institute of Scientific and Technical Information of China (English)

    王志勇; 郑仲承; 孙兰英; 刘新垣

    1997-01-01

    The 126Gln of human interleukin-2 (IL-2) is a conserved amino acid residue. After substitution of 126Gln with Asp, the binding abilities of this mutant to different composites of IL-2 receptor (R) subunits have been determined. Results show that 126Asp-IL-2 has higher affinity to IL-2R α βγ complex and normal affinity to IL-2R α β complex, but loses its binding ability to IL-2R β γ complex, demonstrating that the 126Gln is the residue of human IL-2 which binds to IL-2R 7 subunit.

  10. Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.

    Science.gov (United States)

    Aparicio-Siegmund, Samadhi; Moll, Jens M; Lokau, Juliane; Grusdat, Melanie; Schröder, Jutta; Plöhn, Svenja; Rose-John, Stefan; Grötzinger, Joachim; Lang, Philipp A; Scheller, Jürgen; Garbers, Christoph

    2014-01-01

    The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises of the p35/EBI3 heterodimer (EBI3 shared with IL-27). IL-35 signals via homo- or heterodimers of IL-12Rβ2, gp130 and WSX-1, which are shared with IL-12 and IL-27 receptor complexes, respectively. p35 was efficiently secreted in complex with p40 as IL-12 but not with EBI3 as IL-35 in several transfected cell lines tested which complicates the analysis of IL-35 signal transduction. p35 and p40 but not p35 and EBI3 form an inter-chain disulfide bridge. Mutation of the responsible cysteine residue (p40C197A) reduced IL-12 formation and activity only slightly. Importantly, the p40C197A mutation prevented the formation of antagonistic p40 homodimers which enabled the in vitro reconstitution of biologically active IL-12 with p35 produced in bacteria (p35bac). Reconstitution of IL-35 with p35bac and EBI3 did, however, fail to induce signal transduction in Ba/F3 cells expressing IL-12Rβ2 and gp130. In summary, we describe the in vitro reconstitution of IL-12, but fail to produce recombinant IL-35 by this novel approach.

  11. Recombinant p35 from bacteria can form Interleukin (IL-12, but Not IL-35.

    Directory of Open Access Journals (Sweden)

    Samadhi Aparicio-Siegmund

    Full Text Available The Interleukin (IL-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23 and p35. p35 is shared with the composite cytokine IL-35 which comprises of the p35/EBI3 heterodimer (EBI3 shared with IL-27. IL-35 signals via homo- or heterodimers of IL-12Rβ2, gp130 and WSX-1, which are shared with IL-12 and IL-27 receptor complexes, respectively. p35 was efficiently secreted in complex with p40 as IL-12 but not with EBI3 as IL-35 in several transfected cell lines tested which complicates the analysis of IL-35 signal transduction. p35 and p40 but not p35 and EBI3 form an inter-chain disulfide bridge. Mutation of the responsible cysteine residue (p40C197A reduced IL-12 formation and activity only slightly. Importantly, the p40C197A mutation prevented the formation of antagonistic p40 homodimers which enabled the in vitro reconstitution of biologically active IL-12 with p35 produced in bacteria (p35bac. Reconstitution of IL-35 with p35bac and EBI3 did, however, fail to induce signal transduction in Ba/F3 cells expressing IL-12Rβ2 and gp130. In summary, we describe the in vitro reconstitution of IL-12, but fail to produce recombinant IL-35 by this novel approach.

  12. Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα Antagonist to Inhibit IL-4 Signalling

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    Nayyar Ahmed

    2015-05-01

    Full Text Available Background/Aims: In recent times, allergy has become a financial, physical and psychological burden to the society as a whole. In allergic cascades, cytokine IL-4 binds to IL-4 receptor (IL-4R, consequently producing allergen-specific IgE antibodies by B cells. In addition, among other functions, IL-4 is also responsible for B and T cell proliferation and differentiation. Hence, characterization of novel antagonists that inhibit IL-4 signalling forms the overall aim of this study. Methods: Phage display was used to screen a random 12-mer synthetic peptide library with a human IL-4Rα to identify peptide candidates. Once identified, the peptides were commercially synthesized and used for in vitro immunoassays. Results: We have successfully used phage display to identify M13 phage clones that demonstrated specific binding to IL-4Rα. The peptide N1 was synthesized for use in ELISA, demonstrating significant binding to IL-4Rα and inhibiting interaction with cytokine IL-4. Furthermore, the peptide was tested in a transfected HEK-Blue IL-4 reporter cell line model, which produces alkaline phosphatase (AP. QUANTI-Blue, a substrate, breaks down in the presence of AP producing a blue coloration. Using this colorimetric analysis, >50% inhibition of IL-4 signalling was achieved. Conclusion: We have successfully identified and characterised a synthetic peptide antagonist against IL-4Rα, which effectively inhibits IL-4 interaction with the IL-4Rα in vitro. Since IL-4 interaction with IL-4Rα is a common pathway for many allergies, a prophylactic treatment can be devised by inhibiting this interaction for future treatment of allergies.

  13. Tumorigenicity of IL-1α– and IL-1β–Deficient Fibrosarcoma Cells

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    Irina Nazarenko

    2008-06-01

    Full Text Available Analyzing the growth of fibrosarcoma lines derived from IL-1α–, IL-1β–, or IL-1αβ–knockout (−/− mice in the immunocompetent host revealed that tumor-derived IL-1α and IL-1β exert strong and opposing effects on immune response induction, which prohibited the evaluation of a potential impact on tumorigenicity. Therefore, in vivo growth of IL-1–deficient tumor lines was evaluated in nu/nu mice and was compared with in vitro growth characteristics. All IL-1–deficient fibrosarcoma lines grow in immunocompromised mice. However, IL-1α−/−β–competent (comp lines grow more aggressively, efficiently induce angiogenesis, and recruit inflammatory cells. Despite stronger tumorigenicity of IL-1βcomp lines, IL-1α strengthens anchorage-independent growth, but both IL-1α and IL-1β support drug resistance. Corresponding to the aggressive growth, IL-1βcomp cells display increased matrix adhesion, motility, and cable formation on matrigel, likely supported by elevated αv/β3 and matrix metalloproteinase expression. Recruitment of myeloid cells requires IL-1β but is regulated by IL-1α, because inflammatory chemokine and cytokine expression is stronger in IL-1α−/−βcomp than in IL-1wt lines. This regulatory effect of tumorderived IL-1α is restricted to the tumor environment and does not affect systemic inflammatory response induction by tumor-derived IL-1β. Both sarcoma cell–derived IL-1α and IL-1β promote tumor growth. However, IL-1α exerts regulatory activity on the tumor cell–matrix cross-talk, and only IL-1β initiates systemic inflammation.

  14. Y a-t-il eu un instant zéro ?

    CERN Document Server

    Klein, Etienne

    2015-01-01

    D'où vient l'univers ? Et d'où vient même qu'il y ait un univers ? Aura-t-il une fin ? Pourquoi les humains y sont-ils apparus ? Si ces questions nous obsèdent depuis toujours, celle de l'origine demeure la plus mystérieuse, la plus vertigineuse, d'où la profusion de discours — mythologiques, religieux ou philosophiques — qui tentent d'y répondre. C'est grâce à la science, aux découvertes de Newton, Galilée, Edwin Hubble, Alexandre Friedmann et Georges Lemaître, qu'on peut retracer le grand récit de l'univers, remonter son histoire à 13,7 milliards d'années, jusqu'à cette phase très dense et très chaude qu'on a appelée le big bang. Mais celui-ci n'est pas pour autant, comme on l'a imaginé, cette explosion originelle qui aurait créé tout ce qui existe. Cet instant zéro, peut-on le décrire, le penser, raconter d'où il peut bien provenir ? Et d'où serait venu l'univers d'avant le big bang ? Mystère ! Qu'il y ait eu origine ou pas, on ne part donc jamais de zéro. En parler, c'est p...

  15. Involvement of IL17A, IL17F and IL23R Polymorphisms in Colorectal Cancer Therapy.

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    Inés Omrane

    Full Text Available IL23/IL17 pathway plays an important role in the development of inflammatory bowel diseases (IBD. In general, the genes encoding the cytokines are genetically polymorphic and polymorphisms in genes IL23R and IL17 have been proved to be associated with its susceptibility to inflammatory diseases as well as cancer including colorectal cancer. Moreover, it has been shown that these interleukins are involved in anti-tumor or pro-tumor effects of various cancers. Previously, we showed that there is a significant association between IL17A, IL17F and IL23R polymorphisms as well as the occurrence of colorectal cancer and the clinical features of the disease. The purpose of the present work is to investigate an association between IL17A, IL17F and IL23R polymorphisms in 102 Tunisian patients with colorectal cancer treatment. The association was analyzed by statistical tools. We found that patients with mutated genotypes of IL17A G197A SNP could be a risk factor for the inefficiency of chemotherapy and radiotherapy. Unlike IL17F variant, patients with wild type genotypes require surgery and adjuvant chemotherapy. On the one hand, we found no evidence that supports a significant association between IL23R polymorphism and the combined genotypes of these three genes and the colorectal cancer treatment. On the other hand, we showed that there is an important interaction between IL17A/IL17F polymorphisms and the stage of the disease as well as its treatment. Finally, patients with IL17F wild type genotype highlighted that there is a valid longer OS without all treatments and with radiotherapy and a neoadjuvant chemotherapy. In contrast, we observed that there are no relationships between IL17A, IL23R and the survival of these patients neither with nor without the treatment. Our results suggest that polymorphisms in IL17A and IL17F genes may be a predictive source of colorectal cancer therapy type. Therefore, IL17F may serve as an independent prognostic factor

  16. IL4 — EDRN Public Portal

    Science.gov (United States)

    From NCBI Gene: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008

  17. Mast cell production and response to IL-4 and IL-13.

    Science.gov (United States)

    McLeod, Jamie J A; Baker, Bianca; Ryan, John J

    2015-09-01

    IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a prominent role in stimulating and maintaining the allergic response. As closely related genes, IL-4 and IL-13 share a common receptor subunit, IL-4Rα, necessary for signaling. Here we summarize the literature on mast cell activation associated with IL-4 and IL-13 production, including downstream signaling. We also describe the positive and negative roles each cytokine plays in mast cell immunity and detail the differences that exist between mouse and human mast cell responses to IL-4 and IL-13.

  18. Il cambiamento in psicoterapia psicoanalitica

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    Valentina Tramis

    2010-06-01

    Full Text Available Quali sono i criteri in riferimento ai quali è possibile parlare di cambiamento in psicoterapia psicoanalitica? Cosa lo determina? Quali sono i meccanismi coinvolti nel processo? Per rispondere a queste domande occorre accordarsi su cosa si intenda per cambiamento. Si parla di cambiamento, infatti, sia in riferimento all'esito finale del percorso psicoterapico che relativamente alle modificazioni e agli obiettivi che caratterizzano il processo in itinere. Intendendolo l'esito di una serie di modificazioni strutturali, durature nel tempo, esso si produce attraverso il contributo di numerose variabili tecniche e teoriche, tutte inserite in una logica bi-personale: dalla lettura della modalità relazionale del paziente quale derivato dei Modelli Operativi Interni, all'interiorizzazione di una nuova esperienza relazionale, dal ruolo giocato dall'alleanza terapeutica quale premessa ed esito del lavoro psicoterapico, all'interpretazione e agli interventi del continuum supportivo-espressivo etc. In questa direzione il concetto di cambiamento, nel promuovere una presa di coscienza circa le modalità relazionali che avrebbero determinato la richiesta di intervento psicologico, starebbe per l'acquisizione, da parte della persona, degli strumenti necessari a massimizzare l'espressione di sé e la valorizzazione della propria autonomia e risorse, ai fini del raggiungimento di un più funzionale adattamento all'ambiente, proprio di una condizione di benessere e di un atteggiamento ad essa orientato.

  19. Poéticas del cuerpo monstruoso en la Ilíada y la Odisea

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    Mariano Nava Contreras

    2009-10-01

    Full Text Available Si bien la tradición ha considerado que los poemas homéricos son una fuente determinante en la creación y el desarrollo de la estética griega clásica fundamentada en los ideales de belleza y armonía, también es posible identificar allí una estética de la fealdad y de lo monstruoso, basada en la desmesura y la deformidad. A través de una revisión de la descripción de criaturas como Gorgona, Quimera, Escila, los Cíclopes o el Can Cerbero, es posible elaborar una poética de lo monstruoso que opera en la Ilíada y la Odisea como recurso patémico, pero también como instrumento narrativo.

  20. Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control.

    Science.gov (United States)

    Kapil, Parul; Atkinson, Roscoe; Ramakrishna, Chandran; Cua, Daniel J; Bergmann, Cornelia C; Stohlman, Stephen A

    2009-06-01

    The relative contributions of interleukin-12 (IL-12) and IL-23 to viral pathogenesis have not been extensively studied. IL-12p40 mRNA rapidly increases after neurotropic coronavirus infection. Infection of mice defective in both IL-12 and IL-23 (p40(-/-)), in IL-12 alone (p35(-/-)), and in IL-23 alone (p19(-/-)) revealed that the symptoms of coronavirus-induced encephalitis are regulated by IL-12. IL-17-producing cells never exceeded background levels, supporting a redundant role of IL-23 in pathogenesis. Viral control, tropism, and demyelination were all similar in p35(-/-), p19(-/-), and wild-type mice. Reduced morbidity in infected IL-12 deficient mice was also not associated with altered recruitment or composition of inflammatory cells. However, gamma interferon (IFN-gamma) levels and virus-specific IFN-gamma-secreting CD4 and CD8 T cells were all reduced in the central nervous systems (CNS) of infected p35(-/-) mice. Transcription of the proinflammatory cytokines IL-1beta and IL-6, but not tumor necrosis factor, were initially reduced in infected p35(-/-) mice but increased to wild-type levels during peak inflammation. Furthermore, although transforming growth factor beta mRNA was not affected, IL-10 was increased in the CNS in the absence of IL-12. These data suggest that IL-12 does not contribute to antiviral function within the CNS but enhances morbidity associated with viral encephalitis by increasing the ratio of IFN-gamma to protective IL-10.

  1. IL-27 Regulates IL-18 binding protein in skin resident cells.

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    Miriam Wittmann

    Full Text Available IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP may account for increased IL-18 activity. IL-27 is a cytokine with dual function displaying pro- and anti-inflammatory properties. Here we provide evidence for a yet not described anti-inflammatory mode of action on skin resident cells. Human keratinocytes and surprisingly also fibroblasts (which do not produce any IL-18 show a robust, dose-dependent and highly inducible mRNA expression and secretion of IL-18BP upon IL-27 stimulation. Other IL-12 family members failed to induce IL-18BP. The production of IL-18BP peaked between 48-72 h after stimulation and was sustained for up to 96 h. Investigation of the signalling pathway showed that IL-27 activates STAT1 in human keratinocytes and that a proximal GAS site at the IL-18BP promoter is of importance for the functional activity of IL-27. The data are in support of a significant anti-inflammatory effect of IL-27 on skin resident cells. An important novel property of IL-27 in skin pathobiology may be to counter-regulate IL-18 activities by acting on keratinocytes and importantly also on dermal fibroblasts.

  2. Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1.

    Science.gov (United States)

    Ryan, A W; Thornton, J M; Brophy, K; Daly, J S; McLoughlin, R M; O'Morain, C; Abuzakouk, M; Kennedy, N P; Stevens, F M; Feighery, C; Kelleher, D; McManus, R

    2005-02-01

    Genetic predisposition to coeliac disease (CD) is determined primarily by alleles at the HLA-DQB locus, and evidence exists implicating other major histocompatibility complex-linked genes (6p21) and the CTLA4 locus on chromosome 2q33. In addition, extensive family studies have provided strong, reproducible evidence for a susceptibility locus on chromosome 5q (CELIAC2). However, the gene responsible has not been identified. We have assayed genetic variation at the IL4, IL5, IL9, IL13, IL17B and NR3C1 (GR) loci, all of which are present on chromosome 5q and have potential or demonstrated involvement in autoimmune and/or inflammatory disease, in a sample of 409 CD cases and 355 controls. Thirteen single nucleotide polymorphisms were chosen on the basis of functional relevance, prior disease association and, where possible, prior knowledge of the haplotype variation present in European populations. There were no statistically significant allele or haplotype frequency differences between cases and controls. Therefore, these results provide no evidence that these loci are associated with CD in this sample population.

  3. IL-17 Contributes to Autoimmune Hepatitis

    Institute of Scientific and Technical Information of China (English)

    余海静; 黄加权; 刘阳; 艾国; 严伟明; 王晓晶; 宁琴

    2010-01-01

    The role of interleukin-17 (IL-17) in autoimmune hepatitis (AIH) was investigated. A mouse model of experimental autoimmune hepatitis was established, and the syngeneic S-100 antigen emulsified in complete Freud's adjuvant was injected intraperitoneally into adult male C57BL/6 mice. The IL-17 expression in serum and the livers of the mice models was detected by using ELISA and immunohistochemistry, respectively. IL-17 neutralizing antibody was used to study the biological effect of IL-17 in the experimental...

  4. Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-IL6 and NF-kappa B) which are involved in IL-6 regulation

    NARCIS (Netherlands)

    Dokter, Willem; Koopmans, S.B.; Vellenga, E

    1996-01-01

    Interleukin-10 (IL-10), like IL-4, is known to inhibit cytokine expression in activated human monocytes. We showed that both IL-10 and IL-4 inhibit LPS-induced IL-6 mRNA and protein expression by inhibiting the transcription rate of the IL-6 gene. The strong inhibition of the IL-6 transcription rate

  5. Dynamic changes of IL-2, sIL-2R, IL-6 and IL-8 in children with mycoplasma pneumonia and their clinical significance%肺炎支原体肺炎IL-2、sIL-2R、IL-6、IL-8检测

    Institute of Scientific and Technical Information of China (English)

    刘文彬; 赵文利; 汤雪琴; 袁丽

    2012-01-01

    目的 探讨肺炎支原体肺炎(MPP)急性期和恢复期免疫功能动态变化及临床意义.方法 检测IL-2、sIL-2R、IL-6、IL-8均采用ELISA双抗体夹心法.结果 与对照组比较,MPP患儿急性期sIL-2R、IL-6,IL-8值均明显升高(P<0.01),IL-2值均明显下降(P<0.01),与急性期比较,MPP患儿恢复期IL-2值均明显升高(P<0.01),而sIL-2R、IL-6、IL-8值均明显下降(P<0.01);与对照组比较,MPP患儿恢复期IL-2、sIL-2R、IL-6、IL-8均无明显改变(P>0.05).结论 MPP患儿存在细胞免疫功能低下及紊乱,IL-2、sIL-2R、IL-6及IL-8值恢复较快,检测MPP患儿免疫功能,特别是IL-2、sIL-2R、IL-6和IL-8水平对疗效及预后的判定有重要价值.%Objective To observe the dynamic changes of IL-2, sIL-2R, IL-6 and IL-8 in children with mycoplasma pneumonia( MPP) and to study their clinical significance. Methods The serum levels of IL-2, sIL-2R, IL-6 and IL-8 in 40 children with MPP during the acute stage and convalescent stage were examined with double-antibody sandwich enzyme-linked immu-nosobent assay, and the results were compared with those in 30 normal children. Results The levels of slL-2R, IL-6 and IL-8 were higher and IL-2 was lower during acute stage than those in the normal subjects (P <0. 01). Compared those during the convalescent stage, the level of IL-2 was higher and sIL-2R, IL-6 and IL-8 were lower (P <0. 01) during the acute stage. There were not any significant differences of the levels of these four substances between the normal children and MPP children during the convalescent stage. Conclusion The cellular immune function of children with MPP is impaired and the changes of IL-2, sIL-2R, IL-6 and IL-8 can be used to evaluate the curative effects and prognosis of MPP in children.

  6. The cytokines (IFN-gamma, IL-2, IL-4, IL-10, IL-17) and Treg cytokine (TGF-beta1) levels in adults with immune thrombocytopenia.

    Science.gov (United States)

    Ma, Liangliang; Liang, Yan; Fang, Meiyun; Guan, Yanchun; Si, Yang; Jiang, Feng; Wang, Fangting

    2014-09-01

    Previous studies have indicated that autoimmune diseases might be caused by an imbalance of T helper cells (Th), cytokines, and regulatory T cells (Treg) cytokines. We measured the plasma concentrations of Th1-associated cytokines (IFN-gamma, IL-2), Th2 -associated cytokines (IL-4, IL-10), Th17-associated cytokine (IL-17) and Treg -associated cytokine (TGF-beta1) in adult patients with immune thrombocytopenia (ITP) and evaluated their clinical relevance. Plasma IFN-gamma, IL-2, IL-4, IL-10, IL-17 and TGF-beta1 concentrations of 52 ITP patients and 30 age- and sex-matched healthy controls were measured by enzyme-linked immunosorbent assay method (ELISA). Concentration of Th2 cytokines (IL-4 and IL-10) were significantly higher in ITP patients compared to controls (P cytokines (IFN-gamma, IL-2), Th17 cytokine (IL-17) and Treg cytokine (TGF-beta1) were lower in ITP patients (P cytokine concentration among the other subgroups in ITP patients was found. Among the ITP patients, concentration of IFN-gamma correlated positively and significantly with PAIgG (r = 0.48, P = 0.02). A significant correlation was neither found between other cytokine levels and platelet count, nor between cytokine levels and megakaryocytes number, nor between cytokines levels and PAIgG or GPIIb/IIIa and/or GPIb/IX autoantibodies. The present study demonstrates that an imbalance of Th and Treg cytokines may mediate the pathogenesis of ITP.

  7. Interleukin (IL)-25: Pleiotropic roles in asthma.

    Science.gov (United States)

    Yao, Xiujuan; Sun, Yongchang; Wang, Wei; Sun, Ying

    2016-05-01

    IL-25, also named IL-17E, is a distinct member of the IL-17 cytokine family, which can promote and augment T helper type 2 (Th2) responses locally or systemically. Growing evidence from experimental and clinical studies indicates that the expression of IL-25 and its cognate receptor, IL-17RB/RA, is markedly upregulated in asthmatic conditions. It has also been found that IL-25 induces not only typical eosinophilic inflammation and airway hyperresponsiveness (AHR), but also airway remodelling, manifested by goblet cell hyperplasia, subepithelial collagen deposition and angiogenesis. This review will focus on the discovery, cellular origins and targets of IL-25, and try to update current animal and human studies elucidating the roles of IL-25 in asthma. We conclude that although IL-25 is a pleiotropic cytokine, it may only play its dominant role in a certain specific asthmatic endotype, named 'IL-25 high' phenotype. Thus, targeting IL-25 or its receptor might selectively benefit some subgroups with asthma. Furthermore, the major IL-25 producing as well as responsive cells in the changeable milieu of asthma should be assessed in the future.

  8. Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha?

    Directory of Open Access Journals (Sweden)

    Joanna Matowicka-Karna

    2009-01-01

    Full Text Available In the study performed in a group of patients infected with T. gondii, we evaluated Th2 humoral response (IL-5, IL-6, IL-10 and Th1 cell response (IL-12, TNF-α. The study objective was to assess the effect of T. gondii on chosen indices of the immune response. The study involved 52 women infected with T. gondii (aged 18–42 years prior to antiparasitic treatment. In all the patients, we found IgM (index >0.7 and IgG which exceeded 300 IU/ml. The control group (C consisted of 40 healthy women aged 18–46 years. In the study group (T and in the control group (C, the levels of IgE, IL-5, IL-6, IL-10, IL-12, and TNF-α were determined. In our study, T. gondii patients had twofold higher levels of IL-5 and IL-6 as compared to healthy subjects, which seems to confirm the presence of an inflammatory state. We found the level of IL-10 to be fivefold higher in the course of toxoplasmosis than in healthy controls. The levels of IL-12 and TNF-α were comparable to those observed in healthy controls. The study has revealed that that patients infected with T. gondii show increased production of the humoral response cytokines, whereas the generation of the cell response cytokines remains unchanged.

  9. Liposome-mediated IL-28 and IL-29 expression in A549 cells and antiviral effect of IL-28 and IL-29 on WISH cells

    Institute of Scientific and Technical Information of China (English)

    Ming-cai LI; Hao-yang WANG; Hai-yan WANG; Tao LI; Shao-heng HE

    2006-01-01

    Aim:To construct the recombinant vectors carrying interleukin (IL) -28A,IL-28B and IL-29 cDNAs and express them in human A549 cells,and analyze their antiviral activity in vesicular stomatitis virus (VSV)-infected human immortalized amnion epithelial cell line (WISH cells).Methods:Total cell RNA was extracted from human peripheral blood mononuclear cells (PBMC) activated with poly I:C.The cDNAs encoding human IL-28A.IL-28B.and IL-29 were amplified by reversetranscription polymerase chain reaction (RT-PCR) and inserted into pcDNA3.1/V5-His-TOPO vectors.These recombinant vectors were transfected into human A549 cells by a liposome-mediated gene transfer method.Semiquantitative RT-PCR and Westem blotting were used to detect the mRNA and protein expression of IL-28A,IL-28B,and IL-29.The antiviral activity of IL-28A,IL.28B,and IL-29 was determined by a cytopathic eflfect reduction assay on WISH cells using VSV as a challenge virus.Results:The DNA sequences of the inserts were identical to the published sequences encoding IL-28A,IL-28B,and IL-29 in GenBank.It was transfected cells.Expression of all 3 interleukins in A549 cells was confirmed by Wlestem blot analysis.IL-28 and IL-29 expressed by A549 cells.1ike interferon (IFN)α-2b,were able to protect WISH cells against VSV infection.Conclusion:IL-28 and IL-29 cDNAs were successfully cloned and expressed in eukaryotic cells via transfection with pcDNA3.1/V5-His-TOPO-IL-28/IL-29.Transfection with this vector produced a specific antiviral activity similar to that of IFN-α.which will provide a new tool for the functional study of these cytokines in humans.

  10. Cord Blood Cells Responses to IL2, IL7 and IL15 Cytokines for mTOR Expression

    Directory of Open Access Journals (Sweden)

    Anahita Mohammadian

    2017-04-01

    Full Text Available Purpose: Mammalian target of rapamycin (mTORis important in hematopoiesis and affect cell growth,differentiation and survival. Although previous studies were identified the effect of cytokines on the mononuclear cells development however the cytokines effect on mTOR in cord blood mononuclear cells was unclear. The aim of this study was to evaluate mTOR expression in cord blood mononuclear and cord blood stem cells (CD34+ cells in culture conditions for lymphoid cell development. Methods: Isolation of The mononuclear cells (MNCs from umbilical cord blood were done with use of Ficollpaque density gradient. We evaluated cultured cord blood mononuclear and CD34+ cells in presece of IL2, IL7 and IL15 at distinct time points during 21 days by using flow cytometry. In this study, we presented the role of IL2, IL7 and IL15 on the expression of mTOR in cord blood cells. Results: mTOR expression were increased in peresence of IL2, IL7 and IL15 in day 14 and afterword reduced. However in persence of IL2 and IL15 expression of mTOR significantly reduced. mTOR expression in CD34+ cells decreased significantly from day7 to day 21 in culture. Conclusion: cytokines play important role in mTOR expression during hematopoiesis and development of cord blood mononuclear cells.

  11. Role of IL-1ra/IL-1β and IL-10/IL-6 ratio in coronary artery disease%IL-1Ra/IL-1β及IL-10/IL-6比值在冠心病的作用及其意义

    Institute of Scientific and Technical Information of China (English)

    刘书院; 钟小理; 杨正林; 段克欣

    2012-01-01

    目的:探讨IL-1β、IL-1受体拮抗剂(IL-1 Ra)、IL-10、IL-6水平及IL-1 Ra/IL-1β、IL-10/IL-6比值在冠状动脉粥样硬化性心脏病(冠心痛)患者血清中的变化以及临床意义.方法:选择稳定型心绞痛(SAP)患者26例,不稳定型心绞痛(UAP)患者27例,AMI患者27例,健康体检者30名,分为SAP组、UAP组、AMI组及正常对照组,采用ELISA法检测四组患者血清IL-1β、IL-1 Ra、IL-10、IL-6水平,计算IL-1 Ra/IL-1β、IL-10/IL-6比值,并进行比较.结果:UAP组、AMI组患者的血清IL-1Ra水平均明显低于正常对照组(P<0.05),IL-1β高于对照组(P<0.05);三组冠心痛患者的IL-1 Ra/IL-1β比值均低于正常对照组(P<0.05).三组冠心病患者的血清IL-10、IL-6水平均高于正常对照组(P均<0.05),而IL-10/IL-6比值低于正常对照组(P均<0.05).结论:IL-1β、IL-1Ra、IL-10、IL-6可能参与了冠心病的炎症反应过程,IL-1Ra/IL-1β及IL-10/IL-6比值反映了冠心痛患者的免疫调节状况,其比值高低及动态变化对冠心痛患者的病情监测有重要参考价值.%Objective: To investigate the clinical significance of interleukin-1 β (IL-1β) , interleukin-1 recep- tor antagonist (IL-IRa) , interleukin 10 (IL-10) , interleukin-6 (IL-6) and the ratio of IL-1 Ra/IL-1 β, IL-10/IL-6 in coronary heart disease (CHD). Methods : Patients with stable angina pectoris (SAP group, n = 26), unstable angina pectoris ( UAP group, n = 26 ) , and acute myocardial infarction ( AMI group, n = 27) were involved. Thirty healthy people were selected as control group. Serum level of IL-1 β, IL-IRa, IL-10, IL-6 were detected by Enzyme-linked immunosorbent assay (ELISA) and the ratio of IL-1 Ra/IL-1 β and IL-10/IL-6 were calculated. Results : The serum level of IL-1 Ra in UAP group and AMI group were significantly lower , and IL-1β levels were significantly higher than that in control group (P <0. 05). IL-1 Ra/IL-1 p ratio in CHD patients was lower than in control group (P

  12. Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease

    NARCIS (Netherlands)

    Oosting, M.; Hofstede, H.J.M. ter; Veerdonk, F.L. van de; Sturm, P.D.J.; Kullberg, B.J.; Meer, J.W.M. van der; Netea, M.G.; Joosten, L.A.B.

    2011-01-01

    Interleukin-23 (IL-23) is known to play a crucial role in the development and maintenance of T helper 17 cells. It has been previously demonstrated that IL-17 is involved in experimental Lyme arthritis, caused by Borrelia burgdorferi bacteria. However, the precise role of the IL-23 receptor (IL-23R)

  13. Association Between IL-4 and IL-6 Expression Variants and Gastric Cancer Among Portuguese Population

    Directory of Open Access Journals (Sweden)

    Ana Maria Sampaio

    2015-07-01

    Conclusion: IL-6 and IL-4 expression variants seem to have an important role in GC risk mechanisms. This study provides preliminary evidence that IL-4 and IL-6 polymorphisms, although not directly linked to the disease, may be useful tools in the study of this multifactorial disease.

  14. An activation-induced IL-15 isoform is a natural antagonist for IL-15 function

    Science.gov (United States)

    Zhao, Lei; Hu, Bo; Zhang, Yinsheng; Song, Yuan; Lin, Dandan; Liu, Yonghao; Mei, Yu; Sandikin, Dedy; Sun, Weiping; Zhuang, Min; Liu, Haiyan

    2016-01-01

    Interleukin 15 (IL-15) expression induces the secretion of inflammatory cytokines, inhibits the apoptosis of activated T cells and prolongs the survival of CD8+ memory T cells. Here we identified an IL-15 isoform lacking exon-6, IL-15ΔE6, generated by alternative splicing events of activated immune cells, including macrophages and B cells. In vitro study showed that IL-15ΔE6 could antagonize IL-15-mediated T cell proliferation. The receptor binding assay revealed that IL-15ΔE6 could bind to IL-15Rα and interfere with the binding between IL-15 and IL-15Rα. Over-expression of IL-15ΔE6 in the murine EAE model ameliorated the EAE symptoms of the mice. The clinical scores were significantly lower in the mice expressing IL-15ΔE6 than the control mice and the mice expressing IL-15. The inflammation and demyelination of the EAE mice expressing IL-15ΔE6 were less severe than the control group. Furthermore, flow cytometry analysis demonstrated that IL-15ΔE6 expression reduced the percentages of inflammatory T cells in the spleen and spinal cord, and inhibited the infiltration of macrophages to the CNS. Our results demonstrated that IL-15ΔE6 could be induced during immune activation and function as a negative feedback mechanism to dampen IL-15-mediated inflammatory events. PMID:27166125

  15. Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain

    Energy Technology Data Exchange (ETDEWEB)

    Jones, B.C.; Logsdon, N.J.; Walter, M.R. (UAB)

    2008-09-29

    IL-22 is an IL-10 family cytokine that initiates innate immune responses against bacterial pathogens and contributes to immune disease. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22R1 also pairs with the IL-20R2 chain to induce IL-20 and IL-24 signaling. To define the molecular basis of these diverse interactions, we have determined the structure of the IL-22/sIL-22R1 complex. The structure, combined with homology modeling and surface plasmon resonance studies, defines the molecular basis for the distinct affinities and specificities of IL-22 and IL-10 receptor chains that regulate cellular targeting and signal transduction to elicit effective immune responses.

  16. World heritage site - Bien du Patrimoine Mondial - Kluane/Wrangell-St. Elias/Glacier Bay/Tatshenshini-Alsek

    Science.gov (United States)

    Labay, Keith A.; Wilson, Frederic H.

    2004-01-01

    The four parks depicted on this map make up a single World Heritage Site that covers 24.3 million acres. Together, they comprise the largest internationally protected land-based ecosystem on the planet. The United Nations Educational, Scientific and Cultural Organization (UNESCO) established the World Heritage Program in 1972 for the identification and protection of the world?s irreplaceable natural and cultural resources. World Heritage Sites are important as storehouses of memory and evolution, as anchors for sustainable tourism and community, and as laboratories for the study and understanding of the earth and culture. This World Heritage Site protects the prominent mountain ranges of Kluane, Wrangell, Saint Elias, and Chugach. It includes many of the tallest peaks on the continent, the world's largest non-polar icefield, extensive glaciers, vital watersheds, and expanses of dramatic wilderness. [Les quatre parcs figurant sur cette carte ne constituent qu?un seul site du patrimoine mondial recouvrant plus de 99 millions de km2, ce qui en fait le plus grand ecosysteme terrestre protege par loi internationale. En 1972, L?UNESCO (l?organisation des Nations Unies pour les sciences, l'education et la culture) a etabli le programme du patrimoine mondial afin d?identifier et de proteger les ressources naturelles et culturelles irremplacables de notre plan?te. Si les sites du patrimoine mondial sont si importants c'est parce qu'ils representent a la fois des livres ouverts sur l?histoire de la Terre, le point de depart du tourisme durable et du developpement des collectivites, des laboratoires pour etudier et comprendre la nature et la culture. Ce site du patrimoine mondial assure la protection des chaines de montagnes de Kluane, Wrangell, Saint Elias, et Chugach. On y trouve plusieurs des plus hauts sommets du continent, le plus grand champ de glace non-polaire du monde, d?immenses glaciers, des bassins hydrologiques essentiels, et de la nature sauvage a perte de vue.

  17. Aguas dulces y derecho internacional : el agua como bien común y como derecho humano desde la perspectiva del desarrollo sostenible

    OpenAIRE

    2014-01-01

    Este trabajo tiene por objeto el análisis del régimen internacional de las aguas dulces como bien común y como derecho humano, desde una perspectiva del desarrollo sostenible. El análisis separado del régimen internacional de las aguas dulces compartidas y el régimen internacional del derecho humano al agua y al saneamiento nos permite detectar un cambio de paradigma en la regulación de la materia que puede apuntar una progresiva priorización de la garantía del DHAS y la gestió...

  18. El objeto de protección del derecho penal y el bien jurídico tutelado por el derecho penal en el estado social de derecho

    OpenAIRE

    2014-01-01

    El resumen es una presentación abreviada y precisa (la NTC 1486 de 2008 recomienda El presente texto, tiene como finalidad reconstruir la línea del pensamiento jurídico penal en torno al objeto de protección y la relación que este concepto guarda con el bien jurídico tutelado. Esta reconstrucción nos permitirá demostrar la inviabilidad de la teoría funcionalista de Gunter Jakobs frente al objeto de protección en un Estado Social de Derecho, democrático, participativo y pluralista, fundando en...

  19. LA LEY 4/2012, DE 6 DE JULIO, DE APROVECHAMIENTO POR TURNO DE BIENES DE USOS TURÍSTICOS: ¿NUEVO PRODUCTO TURÍSTICO?

    Directory of Open Access Journals (Sweden)

    Francisca Ramón Fernández

    2014-07-01

    Full Text Available Los productos turísticos adaptados a las TICs y a la combinación entre propiedad y arrendamiento ha sido objeto de legislación desde 1998. La mal denominada multipropiedad, también conocida como aprovechamiento por turno de bienes de usos turístico ha sido regulada recientemente, junto con otros contratos como los productos vacacionales de larga duración. En este trabajo exponemos su consideración como producto, así como los cambios introducidos en la Ley 4/2012, de 6 de julio, y su apertura al ámbito del turismo activo.

  20. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    Directory of Open Access Journals (Sweden)

    Virtudes Rodero Sánchez

    2010-09-01

    Full Text Available El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1 Cronicidad y concepto de sentirse bien-sentirse mal. En la cronicidad este concepto está íntimamente relacionado con la recuperación de las actividades de la vida diaria y es componente importante en la percepción individual del concepto "calidad de vida". (2 Momentos agudos de enfermedad y concepto de sentirse bien-sentirse mal. En el análisis de los relatos del paciente aparecieron aspectos esenciales del fenómeno "sentirse bien-sentirse mal" para aumentar la comprensión de aspectos universales de algunos de sus componentes. Destacar que el fenómeno está íntimamente relacionado con la recuperación de las actividades de la vida diaria, y es un mediador importante en la percepción individual del concepto "calidad de vida". El interés de cara al cuidado es distinguir sus componentes universales, contextualizarlos en la práctica, dentro de las singularidades que presenta cada persona, de modo que nos permita su potenciación. El resultado es un cambio en la experiencia sentida.The object of the present study is to identify cultural knowledges immersed in the feeling-well, feeling-bad phenomenon in different care settings. A qualitative study was undertaken using a phenomenological interpretation approach through a meta-analysis of 18 narratives of profound interviews undertaken by Nursing Science Master Degree Students in different care situations. The categories established were: (1 Chronicity and the concept of feeling well-feeling bad. In this category, this concept is

  1. ENTRE EL HUMANISMO Y EL MERCANTILISMO: EL BIEN COMÚN EN EL ABASTO DE CARNE DE CIUDAD DE MÉXICO, 1708-1716

    OpenAIRE

    Quiroz,Enriqueta

    2011-01-01

    En este artículo se analizan las prácticas políticas ejercidas por miembros del gobierno local en la ciudad de México a principios del siglo XVIII, en torno al abasto de carne. La idea es observar la búsqueda del bien común, pero asentado no solo en bases humanistas, sino también dentro de una política mercantilista, en la que los intereses económicos de la Corona pretenden confluir como en un solo cuerpo con los de sus súbditos.

  2. Reingeniería de procesos en una institución dedicada a la administración de bienes culturales

    OpenAIRE

    Peralta, Dario; Rodriguez Zurita, Maria Denise

    2009-01-01

    El presente artículo trata sobre la reingeniería de procesos realizada dentro de una entidad dedicada a la custodia y administración de bienes culturales patrimoniales teniendo como propósito principal el mejoramiento de su proceso organizacional y administrativo a través de la reorganización, la identificación y mejora de los procesos internos; documentándolos de tal forma que permita a la organización una mejor atención, relación con la comunidad y sus empleados así como un adecuado apro...

  3. AVANCES Y PERSPECTIVAS DEL DERECHO PARA LA RESTITUCIÓN DE BIENES CULTURALES A SUS PAÍSES DE ORIGEN EL CASO DEL PATRIMONIO CULTURAL

    Directory of Open Access Journals (Sweden)

    Antonio José Rengifo Lozano

    2008-01-01

    Partenón, promovido por Grecia y del patrimonio cultural quimbaya en Colombia, la presente ponencia sustenta la tesis de que aunque el derecho para la restitución de bienes culturales se encuentra en etapa inicial de consolidación y por tanto, de seguro tendrá muchos desarrollos en el futuro, existen en la actualidad bases jurídicas suficientes para hacer efectiva esa restitución, necesaria para realizar el legitimo derecho de los pueblos a conocer, apreciar, disfrutar y difundir el patrimonio expresión de su identidad, de su cultura y de su historia.

  4. Avances y perspectivas del derecho para la restitución de bienes culturales a sus países de origen: el caso del patrimonio cultural quimbaya

    OpenAIRE

    Rengifo Lozano, Antonio José

    2013-01-01

    Con base en el estudio comparado de los casos de restitución de los Mármoles del Partenón, promovido por Grecia y del Patrimonio Cultural Quimbaya en Colombia, el presente artículo sustenta la tesis de que aunque el derecho para la restitución de bienes culturales se encuentra en etapa inicial de consolidación y, por tanto, de seguro tendrá muchos desarrollos en el futuro, existen en la actualidad bases jurídicas suficientes para hacer efectiva esa restitución, necesaria para realizar el l...

  5. La prescripción de bienes inmuebles y la garantía de los derechos patrimoniales de las personas

    OpenAIRE

    Salguero Real, Mayra Semira

    2012-01-01

    La presente tesis intitulada “La Prescripción de Bienes Inmuebles y la Garantía de los Derechos Patrimoniales de las Personas” se realiza como requisito previo a la obtención del título de Magister en Derecho Civil y Procesal Civil, desarrollada en cuatro capítulos, cuyo contenido se detalla a continuación. En el Capítulo I, aborda el problema que da lugar a esta investigación, esto es, la ausencia de procedimiento para la ejecución de los títulos escriturarios por la vía Ordinaria medi...

  6. La importancia del embargo de bienes y del comiso en la lucha contra la corrupción: especial referencia a la ley de improbidad administrativa en Brasil.

    OpenAIRE

    Krebs, Fernando Aurvalle

    2011-01-01

    [ES] Tiene como objetivo analizar la importancia del instituto jurídico del embargo de bienes en la lucha contra la corrupción, con especial referencia a la ley de improbidad administrativa brasileña. Estudio de los principales instrumentos internacionales de lucha contra la corrupción. La investigación subraya la necesidad de cambiar los paradigmas de combate a la corrupción, porque esta es, hoy día, un fenómeno internacional que busca los máximos beneficios económicos, por eso, la impor...

  7. Biological significance of soluble IL-2 receptor

    Directory of Open Access Journals (Sweden)

    Calogero Caruso

    1993-01-01

    Full Text Available A NUMBER of receptors for growth factors and differentiation antigens have been found to be secreted or released by cells. Following mononuclear cell (MNC activation and interleukin-2 receptor (IL-2R expression, a soluble form of the Alpha;-chain of IL-2R (sIL-2R is released. The sIL-2R has been shown to be present in the culture supernatants of activated MNCs as well as in normal sera and, in higher amounts, in sera from subjects affected by several diseases including neoplastic, infectious and autoimmune ones, and in sera from transplanted patients suffering allograft rejection. The blood sIL-2R levels depend on the number of producing cells and the number of molecules per cell, so that sIL-2R blood values may represent an index of the number and the functional state of producing cells, both normal and neoplastic. Thus, monitoring of the immune system, mostly T-cells and haematological malignancies might be targets for the measurement of sIL-2R. Since many conditions may influence sIL-2R production, little diagnostic use may result from these measurements. However, since blood sIL-2R levels may correlate with disease progression and/or response to therapy, their measurement may be a useful index of activity and extent of disease. The precise biological role of the soluble form of the IL-2R is still a matter of debate. However, we know that increased sIL-2R levels may be observed in association with several immunological abnormalities and that sIL-2R is able to bind IL-2. It is conceivable then that in these conditions the excess sIL-2R released in vivo by activated lymphoid cells or by neoplastic cells may somehow regulate IL-2-dependent processes. On the other hand, it cannot exclude that sIL-2R is a by-product without biological significance. Finally, it is puzzling that in many conditions in which an increase of blood sIL-2R values has been observed, MNCs display a decreased in vitro capacity to produce sIL-2R. These seemingly contrasting

  8. Progress in the studies of IL-26%IL-26的研究进展

    Institute of Scientific and Technical Information of China (English)

    孟予城; 赵春涛

    2007-01-01

    IL-26是T淋巴细胞对于疱疹病毒saimiri转染的应答产物之一,属于IL-10细胞因子超家族.它通过IL-26受体(IL-26R,IL-20R1/IL-10R2)的介导而激活STATl和STAT3,从而发挥生物学活性.从目前的研究现状来看,IL-26可能与多种疾病有关,但还有待于更多的实验研究证实.

  9. IL-4、IL-13蛋白表达及抗IL-4、IL-13人源单链抗体的筛选%Expression of IL-4 and IL-13 proteins and selection of scFvs against IL-4 and IL-13

    Institute of Scientific and Technical Information of China (English)

    袁青; 黄黎; 郭夕源; 叶迎春; 年四季

    2013-01-01

    Objective:Expression of IL-4 and IL-13 proteins and selection of human scFvs against IL-4 and IL-13 by phage display.Methods:The mRNA of PBMC from healthy volunteer was extracted and cDNA of IL-4 and IL-13 were synthesized by RT-PCR,and the proteins of IL-4 and IL-13 were expressed and identified.The scFvs against IL-4 and IL-13 were selected from a non-immune human scFvs library by phage display with biotinylation IL-4 and IL-13 protein.Results:The size of cDNA of amplified IL-4 was 280 bp,and that of expressed fusion protein was about 27 kD.The size of cDNA of amplified IL-13 was 252 bp,and that of expressed fusion protein was about 25 kD.The human scFvs library was screened for three rounds by ribosome display,and about 37% scFvs has binding activities with IL-4 and about 27% scFvs has binding activities with IL-13.Four scFvs with good binding activities with IL-4 or IL-13 were selected and identified by Western blot.Conclusion:The scFvs against IL-4 and against IL-13 were selected successfully.%目的:表达IL-4和IL-13蛋白,从人源单链抗体文库中分别筛选抗IL-4和抗IL-13单链抗体.方法:采用RT-PCR从健康志愿者外周血单核细胞(PBMC) mRNA中扩增IL-4和IL-13 cDNA;构建硫氧还蛋白融合表达载体,转化大肠杆菌BL21,IPTG诱导表达并对表达产物进行纯化鉴定.以生物素化的IL-4和IL-13为抗原从前期构建的人源抗体文库中采用噬菌体展示技术分别筛选抗IL-4和抗IL-13人源单链抗体(scFv).结果:扩增的IL-4 cDNA大小为280 bp,表达的融合蛋白大小为27 kD左右.扩增的IL-13 cDNA大小为252 bp,表达的融合蛋白大小为25 kD左右.分别以生物素化的IL-4和IL-13蛋白为抗原,采用噬菌体展示技术对人源抗体文库进行3轮富集后,分别有大约37%的scFvs与IL-4有结合特性,有约27%的scFvs与IL-13有结合特性.筛选了4株分别与IL-4和IL-13结合能力强的单链抗体进行了Westem blot鉴定和测序.结论:成功筛选到抗IL-4和抗IL

  10. IL-18 and IL-18 binding protein levels in patients with dengue virus infection

    Institute of Scientific and Technical Information of China (English)

    Chintana Chirathaworn; Yong Poovorawan; Viboonsak Vuthitanachot

    2010-01-01

    Objective:To determine the levels ofIL-18 andIL-18binding protein(BP) in patients with dengue virus infection.Methods: Acute and convalescent sera were collected from each patient. Control group was sera from blood donors. The levels of both IL-18 andIL-18BP were measured byELISA assays.Results: It was shown thatIL-18 andIL-18BPlevels were significantly higher in patients when compared with controls. In addition, the level ofIL-18BP was lower in convalescent than in acute sera.Conclusions: These data suggest that bothIL-18 andIL-18BP production was induced following dengue virus infection. Investigating the regulation of IL-18 by its natural regulator could lead to further understanding of the immune response or immunopathogenesis following dengue virus infection.

  11. Correlation of chronic periodontitis in tropical area and IFN-γ, IL-10, IL-17 levels

    Institute of Scientific and Technical Information of China (English)

    Qi-Ya Fu; Li Zhang; Li Duan; Shi-Yun Qian; Hong-Xia Pang

    2013-01-01

    Objective: To evaluate the correlation of chronic periodontitis in tropical area and IFN-γ, IL-10 and IL-17 levels. Methods: One hundred and forty-eight patients and one hundred and thirty-two healthy control subjects were included in the study. Clinical parameters (PI, GI and PD) and GCF levels of IFN-γ, IL-10 and IL-17 were measured at baseline, week 8, week 16 and week 24 after mechanical removal of dental plaque. IFN-γ and IL-10 were determined with ELISA methods and IL-17 was determined with the cytometric bead array. Results: Removal of dental plaque resulted in improvement in all clinical parameters. Meanwhile, GCF IL-17 declined to control levels, while GCF IFN-γ and IL-10 levels remained unchanged. Conclusions: The decline of GCF IL-17 levels in patients with resolution of periodontitis suggests that IL-17 is involved in the periodontal inflammatory process.

  12. Il gioco le leggi naturali governano il caso

    CERN Document Server

    Eigen, Manfred

    1986-01-01

    Manfred Eigen, Premio Nobel per la chimica nel 1967, e la sua collaboratrice Ruthild Winkler hanno voluto con questo libro uscire allo scoperto, esponendo in una trattazione complessa ma comprensibile per ogni lettore veramente interessato una teoria molto audace, basata su ricerche e scoperte di Eigen stesso e di altri (come per esempio Thom e Prigogine) che in questi ultimi anni sono al centro dell’attenzione degli scienziati, anche se non sempre sono filtrate al di fuori della loro cerchia. Questa teoria ha come perno la nozione di gioco: e non già in una o più delle innumerevoli accezioni della parola, ma in tutte, con l’aggiunta di una ulteriore accezione che sottende tutte le altre: il gioco come struttura intelligibile emergente dal divenire caotico, quindi come fenomeno «che ha guidato fin dall’inizio il corso dell’Universo». Gioco, in questo libro, è dunque un «fenomeno naturale», non specificamente umano. I giochi che noi tutti giochiamo sono soltanto la schiuma variegata di un flutto...

  13. La protección del “paisaje sonoro”: Los toques manuales de campanas y su declaración como Bien de Interés Cultural

    Directory of Open Access Journals (Sweden)

    Francisca Ramón Fernández

    2014-06-01

    Full Text Available En el presente trabajo analizamos la protección de los toques manuales de campanas y su declaración como Bien de Interés Cultural Inmaterial por parte de la legislación de patrimonio cultural valenciano. A través de la evolución histórica del bien podemos observar las razones de su protección y nos ha llevado a cuestionarnos si ha sido adecuado su consideración como paisaje sonoro, concepto muy alejado en el ámbito jurídico y que no es compartido plenamente. Siendo la primera vez que se protege este bien, resulta especialmente interesante la ampliación de la protección a los denominados elementos que forman parte del bien, como es el caso de las partituras.

  14. Nietzsche e il modello intuizionista in morale

    Directory of Open Access Journals (Sweden)

    Francesco Margoni

    2013-05-01

    Full Text Available All’inizio del nuovo secolo lo psicologo Jonathan Haidt propone un modello del giudizio morale ch’entra in opposizione ad una duratura tradizione di pensiero, quella per cui il giudizio morale è causato dalla ragione. In psicologia, a sostenere il modello razionalista, sono stati, per lo più, Piaget e Kohlberg. Sul versante filosofico, possiamo affermare che buona parte degli addetti ai lavori si sono schierati a favore della concezione razionalistica. Razionalisti in morale erano Socrate, che introdusse l’intellettualismo etico, il cristianesimo, Cartesio, Kant. Haidt, invece, elaborando il suo modello descrittivo su dati sperimentali di natura empirica, arriva alla conclusione che il giudizio morale, nella maggior parte dei casi, non è causato dal ragionamento cosciente. Piuttosto, il ragionamento entrerebbe in gioco una volta formulato il giudizio morale, come forza di razionalizzazione a posteriori. Haidt chiama questo modello "intuizionista".

  15. IL-1β up-regulates expression of IL-8 in endometrial stromal cells in vitro

    Institute of Scientific and Technical Information of China (English)

    Zhang Guiyu; Ren Shuwen; Zhang Youzhong; Yang Xingsheng

    2005-01-01

    Objective:To investigate the effects of interleukin-1beta (IL-1β) on expression of IL-8 in endometrial stromal cells (ESC) and evaluate the relationship between IL1 β and IL-8 ,and the significance of IL-1β in the development of endometriosis. Methods:The endometrial stromal cells obtained from patient with and without endometriosis cultured within 3 ~5 passage were exposed to various concentrations of IL-1β. The amount of IL-8 protein was assessed by ELISA. The expression of IL-8 mRNA was determined by RT-PCR. Results: 1. IL-8 protein was detected in culture supernatant of which the cells were not treated with IL-1β. The amount of IL-8 protein secretion increased obviously after stimulation with IL-1β at 1.0ng/ml for 4h and the peak of secretion was at 12h. 2. Expression of IL-8 mRNA was positive in unstimulated endometrial stromal cells. However, after stromal cells were incubated with IL-1β, the intensity of expression of IL-8 mRNA was obviously increased and demonstrated a dose-and timedependent manner. Increase of IL-8 mRNA was observed following stimulation with IL-1β for 4h ,and the peak at 12h. Conclusions:IL-1β induces endometrial stromal cell of endometriosis to express IL-8 not only at transcription level but also at post-transcription level. This up-regulation is dose-and time-dependent. IL-1β may play an important role in the onset of endometriosis.

  16. IL-15与自身免疫病%IL-15 and Autoimmune Disease

    Institute of Scientific and Technical Information of China (English)

    李文新; 张学光

    2003-01-01

    IL-15的组织分布、表达调控及具体生物学功能等方面对IL-15与自身免疫病(autoimmune disease,AID)的关系进行分析和阐述,并列举了5种与IL-15相关的AID及4种以IL-15/IL-15R为靶向的AID治疗策略.

  17. Clinical significance of the Changes of Serum Levels of IL-2,IL-6,IL-10,IL-18 and T cell subset in patients with chronic nephritis%慢性肾炎治疗前后血清IL-2、IL-6、IL-10、IL-18和T淋巴细胞亚群检测意义

    Institute of Scientific and Technical Information of China (English)

    刘薇娜; 鲍培玉; 蒋全

    2010-01-01

    目的 探讨慢性肾炎患者治疗前后血清IL-2、IL-6、IL-10、IL-18和T淋巴细胞亚群的变化.方法 分别应用放免法、ELISA法和单克隆抗体法对30例慢性肾炎患者治疗前后进行了血清IL-2、IL-6、IL-10、IL-18和T淋巴细胞亚群水平的检测,并与35名正常健康人作比较.结果 慢性肾炎患者在治疗前血清IL-2和CD4/CD8比值明显低于正常人组(P<0.05),而IL-6、IL-10和IL-18水平高于正常人组(P<0.01);经半年治疗后血清IL-2、IL-6、IL-10、IL-18和CD4/CD8与治疗前组比较差异有统计学意义(P<0.05).结论 检测慢性肾炎患者血清IL-2、IL-6、IL-10、IL-18和T淋巴细胞亚群水平对判断病情及其预后均具有一定的临床实用价值.

  18. Interleukin (IL)1beta, IL-1alpha, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy.

    Science.gov (United States)

    Kanemoto, K; Kawasaki, J; Miyamoto, T; Obayashi, H; Nishimura, M

    2000-05-01

    Proinflammatory cytokines, including interleukin (IL)-1beta, are known to modulate effects of neurotoxic neurotransmitters discharged during excitation or inflammation in the central nervous system (CNS). They also regulate development of glial scars at sites of CNS injury. To elucidate a genetic predisposition of temporal lobe epilepsy with hippocampal sclerosis (TLE-HS+), we studied polymorphisms in the IL-1beta, IL-1alpha, and IL-1 receptor antagonist (IL-1RA) genes in 50 patients with TLE-HS+ and in 112 controls. Fifty-three patients who had TLE without HS were also examined (TLE-HS-) as disease controls. The distribution of the biallelic polymorphism in the promoter region at position -511 of the IL-1beta gene (IL-1B-511) was significantly different both between TLE-HS+ patients and controls and between TLE-HS+ and TLE-HS- patients. The differences were due to overrepresentation of the homozygotes for IL-1B-511*2, which is suggested to be a high producer of IL-1beta, in TLE-HS+ patients compared with both controls and TLE-HS- patients. In contrast, there was no difference between TLE-HS- patients and controls. Our data suggest that, in the homozygotes for IL-IB-511*2, minor events in development such as febrile convulsions could set up a cascade leading to HS.

  19. Interleukin-10 (IL-10) inhibits Borrelia burgdorferi-induced IL-17 production and attenuates IL-17-mediated Lyme arthritis.

    Science.gov (United States)

    Hansen, Emily S; Medić, Velinka; Kuo, Joseph; Warner, Thomas F; Schell, Ronald F; Nardelli, Dean T

    2013-12-01

    Previous studies have shown that cells and cytokines associated with interleukin-17 (IL-17)-driven inflammation are involved in the arthritic response to Borrelia burgdorferi infection. Here, we report that IL-17 is a contributing factor in the development of Lyme arthritis and show that its production and histopathological effects are regulated by interleukin-10 (IL-10). Spleen cells obtained from B. burgdorferi-infected, "arthritis-resistant" wild-type C57BL/6 mice produced low levels of IL-17 following stimulation with the spirochete. In contrast, spleen cells obtained from infected, IL-10-deficient C57BL/6 mice produced a significant amount of IL-17 following stimulation with B. burgdorferi. These mice developed significant arthritis, including erosion of the bones in the ankle joints. We further show that treatment with antibody to IL-17 partially inhibited the significant hind paw swelling and histopathological changes observed in B. burgdorferi-infected, IL-10-deficient mice. Taken together, these findings provide additional evidence of a role for IL-17 in Lyme arthritis and reveal an additional regulatory target of IL-10 following borrelial infection.

  20. 手足口病患儿血清中IL-6 IL-10 IL-13及IL-17的变化及临床意义%Changes and clinical significance of serum IL-6,IL-10,IL-13 and IL-17 levels in children with hand-foot-mouth disease

    Institute of Scientific and Technical Information of China (English)

    陈笑辉; 樊冰

    2013-01-01

    Objective To study the changes and clinical significance of serum IL-6,IL-10,IL-13,IL-17 levels in the children with hand-foot-mouth disease (HFMD).Methods The serum concentration of IL-6,IL-10,IL-13,IL-17 in 46 case of HFMD children with acute stage and recovery stage and 40 cases of healthy controls were measured by ELISA.The data was analyzed by statistical SPSS software.Results In acute stage,the levels of IL-6,IL-10,IL-13,IL-17 in children of severe HFMD were higher than those in general children (P<0.01),showing significant difference from those in healthy controls (P<0.01).In recovery stage,the levels of IL-6 and IL-17 of HFMD were significantly lower than those in acute stage,and also no significant difference showed from those in general children and in healthy controls (P>0.05).Conclusion The levels of IL-6 and IL-17 were significantly increased in acute stage of HFMD children.The persistent elevation of serum IL-10 and IL-13 levels were found in HFMD patients after convalescence.%目的 探讨手足口病患儿血清中IL-6 IL-10 IL-13及IL-17的变化及临床意义.方法 采用酶联免疫吸附实验(ELISA)抗体夹心法测定46例手足口病患儿急性期、恢复期及40例健康体检儿童血清IL-6、IL-10、IL-13、IL-17的含量,对手足口病患儿急性期、恢复期进行比较,同时对其中重症患儿、普通患儿进行比较,用统计软件进行统计学分析.结果 急性期重症组与普通组IL-6、IL-10、IL-13及IL-17水平均明显升高,与对照组比较有统计学意义(P<0.01),重症组与普通组比较有统计学意义(P<0.01).恢复期重症组与普通组IL-6、IL-17较急性期下降,普通组与对照组比较无统计学意义(P>0.05),而重症组与对照组比较有统计学意义(P<0.01),但是IL-10、IL-13重症组和普通组均较急性期下降,但仍高于对照组,两组与对照组比较有统计学意义(P<0.01).结论 炎症因子IL-6、IL-17在急性期水平显著升高,而抑制性细胞因子IL

  1. Algunas consideraciones sobre el bien jurídico tutelado en los delitos sobre la ordenación del territorio en el Nuevo Código Penal Español

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    Diego Silva Forné

    2015-09-01

    Full Text Available  La ciencia penal contemporánea considera ~n su amplia mayoría como misión del Derecho Penal, la tutela de bienes jurídicos; en particular, su protección se despliega frente a las agresiones más graves de que son éstos objeto, ya que también en los restantes sectores del ordenamiento jurídico cabe la salvaguarda de los mismos (...Contenido: Precisiones previas. Nociones sobre el concepto de bien jurídico.Breve sinopsis de su evolución. Planteos actuales. Concepciones de carácter formal. Concepciones materiales. Teorías de fundamento constitucional. Teorías de concepto sociológico. Funciones de bien jurídico. Los bienes jurídicos colectivos. El bien jurídicoprotegido en los delitos sobre la ordenación del territorio. Conceptos conexos. Discusión sobre el bien jurídico tutelado.Consideraciones político-criminales.

  2. ICH 患者血清和血肿液中 IL-4、IL-6、IL-8、IL-10的变化研究%Hematoma fluid and serum of patients with acute cerebral hemorrhage about IL-4, IL-6, IL-8, and IL-10 Changes

    Institute of Scientific and Technical Information of China (English)

    赵金安; 白西民

    2016-01-01

    目的:观察急性脑出血(ICH)患者血清和血肿液中 IL-4、IL-6、IL-8、IL-10的变化。方法:选取80例在我院治疗的基底节区脑出血患者,按照发病时间将患者分为5组(发病时间≤6h、6h <发病时间≤12h、12h <发病时间≤24h、24h <发病时间≤72h、3d <发病时间≤7d),检测各组血清和血肿液中 IL-4、IL-6、IL-8、IL-10的含量以及出血量和水肿量;另选取21例健康体检者,检测其血清 IL-4、IL-6、IL-8、IL-10的含量作对照。结果:IL-4、IL-6、IL-8、IL-10在患者静脉血、血肿液中的浓度均显著高于正常对照组,而患者静脉血与血肿液中 IL-4、IL-6、IL-8、IL-10浓度比较,差异无统计学意义。基底节区脑出血患者发病时间≤6h 与正常对照组比较,除 IL-10浓度升高不明显外,IL-4、IL-6、IL-8浓度均明显升高;24h <发病时间≤72h 时,IL-4、IL-6、IL-8浓度与其他各时段比较,以及3d <发病时间≤7d时,IL-10浓度与其他各时段比较,差异均具有统计学意义。各时段出血量和水肿量比较,差异均无统计学意义,出血量和水肿量均在发病时间≤6h至12h <发病时间≤24h 逐渐增大,12h <发病时间≤24h 达到峰值。结论:ICH 患者静脉血、血肿液中 IL-4、IL-6、IL-8浓度可以作为早期检测(≤6h)ICH 的指标,并可通过不同炎症因子的含量变化判断 ICH 患者发病时间,且患者发病一周内周围脑组织出血量和水肿量变化不大。%Objective To observe the changes of IL-4, IL-6, IL-8, IL-10 in serum and hematoma of ICH. Methods 80 cases ICH patients were divided into five groups(<6h, 6-12h, 12-24h, 24-72h, 3-7d). The control group were 21 healthy persons serum. The content of IL-4, IL-6, IL-8, IL-10 in different time were compared and the amount of bleeding and edema. Results IL-4, IL-6, IL-8, IL-10 in patients with venous hematoma fluid concentrations were

  3. Bien-être émotionnel au travail et changement organisationnel Emotional Well-Being at Work and Organizational Change: The Essilor Case Bienestar emocional en el trabajo y cambio organizacional : el caso de Essilor

    Directory of Open Access Journals (Sweden)

    Catherine Remoussenard

    2013-05-01

    Full Text Available Aujourd’hui, la plupart des entreprises mettent en place des projets de changements organisationnels afin de s’adapter aux modifications d’un environnement très concurrentiel. Ce faisant, elles se heurtent à des difficultés liées notamment aux situations de mal-être que ces changements peuvent induire. Notre étude vise à explorer les effets de nouvelles politiques managériales sur le bien-être émotionnel des salariés. Plus précisément, nous explorons les politiques mises en œuvre par un des sites du Groupe Essilor dans le contexte d’un changement organisationnel. Nous analysons d’un point de vue quantitatif et qualitatif les effets induits par ces politiques sur les salariés et sur la façon dont Essilor-Dijon en tient compte dans sa gestion des collaborateurs pour améliorer le bien-être au travail. À la lumière de nos résultats, il apparaît que les émotions sont au cœur de la conduite du changement, pouvant jouer le rôle de freins ou de leviers en fonction des choix managériaux.Nowadays, companies are implementing organizational change in order to be able to adapt to an increasingly competitive environment. Because of this context, firms are often confronted with problems linked to stressful situations that they themselves have brought about. We explored the policies which were applied by one of the branches of the Essilor Group in an organizational change context. First, we quantitatively and qualitatively analyzed the effects which this policy has had on stress-related issues. Second, we looked at how Essilor-Dijon took into account these effects in managing its staff so as to improve their well-being at work. Our results show that emotions appear to be at the heart of managing change and can either be obstacles or facilitators, depending on the choices made by management.Hoy en día, la mayoría de las empresas están llevando a cabo proyectos de cambio organizacional con el objetivo de adaptarse a las

  4. Retos para el desarrollo de una economía no convencional y perspectivas sobre la valoración de bienes ambientales

    Directory of Open Access Journals (Sweden)

    Alexander Martínez R.

    2010-12-01

    Full Text Available La teoría económica se ha dividido claramente en dos grandes narrativas: la economía convencional y la economía no convencional. La primera no solo se caracteriza por su arsenal matemático, sino también por su alta carga ideológica en la perspectiva del liberalismo económico. La segunda es una teoría en construcción, con sendos avances metodológicos y estudios de campo, pero aún se encuentra profundamente cuestionada por la epistemología positivista. Este ensayo pretende abreviar los temas más críticos de aquellas dos teorías económicas, con especial énfasis en los instrumentos analíticos de la economía convencional para valorar bienes ambientales (economía ambiental, y mostrar resumidamente los supuestos teóricos y fortalezas de la economía no convencional (bioeconomía en materia de valoración de bienes ambientales. Finalmente, se propone un modelo de interpretación del mercado que reestructura la noción de Valor Económico Total de la economía ambiental, en una perspectiva bioeconómica.

  5. Prolegómenos al vivir bien-buen vivir: una evaluación normativa y práctica

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    Edwin Cruz Rodríguez

    2014-09-01

    Full Text Available Este trabajo examina el concepto de vivir bien-buen vivir ponderando sus contribuciones y limitaciones. Esta cosmovisión tiene un horizonte normativo más ambicioso que el paradigma del desarrollo, pues apuesta por una concepción de la pobreza y la riqueza que no se reduce a la acumulación de bienes materiales, una economía que comprende sus efectos sobre la naturaleza y se centra en la satisfacción de necesidades, y una descolonización de los saberes. No obstante, se caracteriza por un déficit de operacionalización que se manifiesta en la dificultad para definir políticas concretas e indicadores de medición precisos.******This article examines the concept of live well-good living, by analyzing its contributions and limitations. This worldview has a normative horizon more ambitious than the development paradigm, as it wagers for a poverty and wealth conception that is not limited to the accumulation of material goods, but it is an economy aware of its effects on nature and the satisfaction of needs and the decolonizing of knowledge. Nevertheless, it is characterized by an operationalization deficit that is shown through the difficulty to establish specific policies and accurate indicators of measurement.

  6. La casa y el ajuar de la familia Coronel a través de un inventario de bienes del siglo XVI

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    De la Peña Barroso, Efrén

    2015-12-01

    Full Text Available In the last years we have been working on the person of don Abraham Seneor/Fernán Pérez Coronel and his offspring, mainly from his son Íñigo López Coronel. In this occasion we will focus on the structure of the dwelling house and the household goods of the family through an inventory made in Segovia in 1522. This document will allow us to know the wealth level, the shy investment in luxury goods and the list of part of the household goods of this important family of Segovian conversos.Desde hace ya varios años estamos trabajando en la figura de don Abraham Seneor/Fernán Pérez Coronel y su descendencia, sobre todo por la vía de su hijo Íñigo López Coronel. En esta ocasión, estudiaremos la estructura espacial de su casa, sus bienes muebles y el ajuar de esta rama familiar a través de un inventario de bienes realizado en sus «casas principales» de la ciudad de Segovia en el año 1522. Este inventario nos permitirá acercarnos a los niveles de riqueza, a la escasa inversión en productos de lujo y al conocimiento de gran parte del ajuar de esta importante familia de judeoconversos segovianos.

  7. Bienes y servicios ecosistémicos en la planificación y gestión de áreas urbanas consolidadas

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    Rafael Francesconi Latorre

    2014-06-01

    Full Text Available En el contexto de una planificación que declara privilegiar los elementos de la estructura ecológica, pero que podría comprometer la provisión de suelos para soportar coberturas que ofrezcan bienes y servicios ecosistémicos, se presenta un aporte a la discusión sobre cómo lograr un balance entre densificación y provisión de estos bienes y servicios, mediante la reconstrucción de la transformación de la cobertura de un segmento de la cuenca del río Fucha en Bogotá en un lapso de 77 años y la verificación de las relaciones de dicha transformación con los instrumentos de planificación y gestión. Los resultados obtenidos sugieren una regulación reactiva, con limitaciones para conducir la ocupación del territorio, de la que se puede esperar una acentuación de la aridez. Estos resultados sustentan las conclusiones sobre la necesidad de replantear la regulación sobre áreas consolidadas e introducir instrumentos de gestión de la cobertura.

  8. Gasto particularista en bienes públicos locales: índice de desviación Particularistic expenditure on local public goods: an index of deviation

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    María Alejandra Armesto

    2012-09-01

    Full Text Available El gasto particularista del gobierno se opone al gasto programático. Los dos tipos de medidas clasifican los beneficios de políticas como particularistas si son bienes exclusivos o si son explicados por variables políticas. Este artículo desarrolla un índice de gasto particularista en bienes públicos locales medido como desviación con respecto al programa. Se aplica el índice a la oferta de servicios básicos por administraciones subnacionales seleccionadas en México y Argentina. Se muestra que el índice corre menos riesgos de sobreestimar o subestimar el gasto particularista y el gasto programático que las medidas existentes.This article compares particularistic and programmed government spending. The two types of measures classify the benefits of policies as particularistic if they are exclusive goods or if they are determined by political variables. This article contains an index of particularistic expenditure on local public goods, measured as a deviation from the program. It applies this index to the supply of basic services from selected sub-national administrations in Mexico and Argentina. It shows that this index is less likely to over- or under-estimate particularistic and programmatic expenditure than existing measures.

  9. La repercusión del valor razonable de los bienes inmuebles en la utilidad de los estados financieros: una nota de investigación

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    Andrés Navarro Galera

    2009-01-01

    Full Text Available La elección en la reciente reforma contable española del criterio de valor razonable en lugar del coste histórico como base de valoración para determinados activos ha generado cierta controversia. Este trabajo estudia la posible incidencia de la adopción del valor razonable para el registro contable de los bienes inmuebles sobre la relevancia y la fiabilidad de la información financiera. El estudio empírico está basado en una encuesta sobre las percepciones de 151 responsables de la contabilidad de empresas españolas del sector de la construcción sobre la utilidad y fiabilidad de la información financiera basada en el valor razonable. El análisis de los resultados nos ha permitido concluir que, respecto al coste histórico, los responsables de contabilidad perciben que el valor razonable de los bienes inmuebles generaría estados financieros más útiles para representar la imagen fiel del patrimonio de la empresa. No obstante, los encuestados conciben la información financiera bajo valor razonable como menos objetiva y verificable. Asimismo, hemos comprobado que el tamaño de la empresa puede influir en la opinión de la repercusión del valor razonable sobre la relevancia y fiabilidad de los estados financieros.

  10. Expanding Diversity in Molecular Structures and Functions of the IL-6/IL-12 Heterodimeric Cytokine Family

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    Hideaki Hasegawa

    2016-11-01

    Full Text Available The interleukin (IL-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they are composed of two distinct subunits forming a heterodimer and each cytokine and receptor subunit shares with each other. The members of this cytokine family are increasing; currently, there are more than 6 cytokines, including the tentatively named cytokines IL-Y (p28/p40, IL-12 (p35/p40, IL-23 (p19/p40, IL-27 p28/Epstein-Barr virus-induced protein 3 (EBI3, IL-35 (p35/EBI3, and IL-39 (p19/EBI3. This family of cytokines covers a very broad range of immune responses, including pro-inflammatory responses such as helper T (Th1, Th2, and Th17 to anti-inflammatory responses such as regulatory T (Treg cells and IL-10-producing Treg cells. IL-12 is the first member of this family, and IL-12, IL-23, and IL-27 are mainly produced by activated antigen-presenting cells such as dendritic cells and macrophages. IL-12 plays a critical role in the promotion of Th1 immune responses by inducing interferon-γ production to combat pathogens and malignant tumors. IL-23 induces IL-17 production and is necessary to maintain pathogenic Th17 cells that cause inflammatory and autoimmune diseases. IL-27 was initially reported to play a critical role in promotion of Th1 differentiation; however, subsequent studies revealed that IL-27 has broader stimulatory and inhibitory roles by inducing IL-10-producing Treg cells. IL-35 is produced by forkhead box P3+ Treg cells and activated B cells and has immunosuppressive functions to maintain immune tolerance. The most recently identified cytokine, IL-39, is produced by activated B cells and has pro-inflammatory functions. The cytokine tentatively named IL-Y seems to have anti-inflammatory functions by inhibiting Th1 and Th17 differentiation. In addition, individual cytokine subunits were also shown to have self-standing activities. Thus

  11. Contribution of IL-1 to resistance to Streptococcus pneumoniae infection.

    Science.gov (United States)

    Kafka, Daniel; Ling, Eduard; Feldman, Galia; Benharroch, Daniel; Voronov, Elena; Givon-Lavi, Noga; Iwakura, Yoichiro; Dagan, Ron; Apte, Ron N; Mizrachi-Nebenzahl, Yaffa

    2008-09-01

    The role of IL-1 in susceptibility to Streptococcus pneumoniae infection was studied in mice deficient in genes of the IL-1 family [i.e. IL-1alpha-/-, IL-1beta-/-, IL-1alpha/beta-/- and IL-1R antagonist (IL-1Ra)-/- mice] following intra-nasal inoculation. Intra-nasal inoculation of S. pneumoniae of IL-1beta-/- and IL-1alpha/beta-/- mice displayed significantly lower survival rates and higher nasopharyngeal and lung bacterial load as compared with control, IL-1alpha-/- and IL-1Ra-/- mice. Treatment of IL-1beta-/- mice with rIL-1beta significantly improved their survival. A significant increase in blood neutrophils was found in control, IL-1alpha-/- and IL-1Ra-/- but not in IL-1beta-/- and IL-1alpha/beta-/- mice. Local infiltrates of neutrophils and relatively preserved organ architecture were observed in the lungs of IL-1alpha-/- and control mice. However, S. pneumoniae-infected IL-1beta-/-, IL-1alpha/beta-/- and IL-1Ra-/- mice demonstrated diffuse pneumonia and tissue damage. Altogether, all three isoforms contribute to protection against S. pneumoniae; our results point to differential role of IL-1alpha and IL-1beta in the pathogenesis and control of S. pneumoniae infection and suggest that IL-1beta has a major role in resistance to primary pneumococcal infection while the role of IL-1alpha is less important.

  12. 白介素19(IL-19)

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    白介素-10(IL-10)是一种具有重要免疫调节功能的多效性细胞因子,它能影响免疫系统中多种类型细胞的活性。新近,美英科学家克隆了一种独特的人mRNA,它编码名为白介素19(Interleukin-19,IL-19)的新型IL-10同源物。IL-19基因邻近IL-10基因,都位于1号染色体上。IL-19基因由5个外显子和4个内含子组成,由二种不同的启动子转录。IL-19与IL-10有21%aa同源。IL-19mRNA是在活化的巨噬细胞中发现的,其表达相似而又不同于IL-10。IL-19与IL-10的序列比较表明两者不可能共享一种受体。IL-19的鉴定增加了已鉴定的IL-10同源物数并证明了IL-10相关蛋白家族的存在。在活化的巨噬细胞中,IL-19的表达模式不同于IL-10,并且可能通过不同于典型的IL-10受体复合物的不同受体进行信号转导。 [黄仕和译自Gallgaher G et al.Immunol Letters,2000,73(2,3):206

  13. IL-10 Function, Regulation, and in Bacterial Keratitis

    OpenAIRE

    Hazlett, Linda D.; Jiang, Xiaoyu; McClellan, Sharon A.

    2014-01-01

    The immune system protects the host from pathogenic microbes, but tight regulation of the evoked response is requisite to limit bystander damage. The interleukin (IL)-10 family of cytokines, composed of 9 members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and 3 distantly related members, IL-28A, IL-28B, and IL-29, plays a central role in this regulation. IL-10 family cytokines emerged before the adaptive immune response and elicit diverse host defense mechanisms, especially from epithelial ce...

  14. I lectores medioevali tra il libro e il testo

    Directory of Open Access Journals (Sweden)

    Federica Riviello

    2012-06-01

    Full Text Available L’intento del lavoro è di problematizzare alcuni aspetti, generalmente ritenuti emblematici, della relazione tra i litterati medievali e il libro – nelle sue declinazioni di Testo sacro, Libro della natura e auctoritates. L’impiego, come strumenti di lavoro, di concetti di recente elaborazione e di osservazioni di pensatori contemporanei sull’argomento, non è finalizzato ad attualizzare tale relazione, quanto piuttosto ad ampliare i punti di vista su di essa e a metterne alla prova la capacità di offrire originali spunti di riflessione. Le proposte teoriche di Jacques Derrida, Michel Foucault e Roland Barthes sono qui adoperate come esemplificazioni di un’interpretazione che ha storicamente reso quasi paradigmatico il modo di leggere dei docti, specialmente altomedievali. Tuttavia, alcune definizioni della Scrittura – il libro per eccellenza – proposte da questi ultimi, nonché la teorizzazione del suo quadruplice senso sembrano smussare la radicalità di queste osservazioni. Concetti quali “funzione-autore” di Foucault e “testo” di Barthes sono invece adottati per considerare all’interno di una diversa cornice teorica il confronto dei doctores, in particolare bassomedievali, con le cosiddette auctoritates. Nella visione ordinaria la reverenza nei confronti dell’autore, divino o umano, la ricerca e la riproposizione fedele di un significato univoco dell’opera aldilà dei segni, naturali o culturali, che lo veicolano costituiscono tratti tipici dell’atteggiamento dei lettori medievali. A fronte di questi aspetti, tuttavia, è possibile sottolinearne altri eterodossi e perlopiù trascurati, quali la rilevanza attribuita all’interpretazione, prassi ineludibile e da disciplinare, al ruolo del lettore e alla sua fruizione attiva e produttiva dei testi. The aim of the work is to problematize some aspects generally considered representative of the relationship between medieval savants and the book - in its variations

  15. IL-21 Receptor Expression in Human Tendinopathy

    Science.gov (United States)

    Campbell, Abigail L.; Smith, Nicola C.; Reilly, James H.; Kerr, Shauna C.; Leach, William J.; Fazzi, Umberto G.; Rooney, Brian P.; Murrell, George A. C.; Millar, Neal L.

    2014-01-01

    The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level. The level of expression of IL-21R message/protein in human tenocytes was significantly upregulated by proinflammatory cytokines (TNFα/IL-1β) in vitro. These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages. Despite a lack of IL-21 expression, these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy. PMID:24757284

  16. IL-21 Receptor Expression in Human Tendinopathy

    Directory of Open Access Journals (Sweden)

    Abigail L. Campbell

    2014-01-01

    Full Text Available The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level. The level of expression of IL-21R message/protein in human tenocytes was significantly upregulated by proinflammatory cytokines (TNFα/IL-1β in vitro. These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages. Despite a lack of IL-21 expression, these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy.

  17. Emerging role of IL-17 in atherosclerosis.

    Science.gov (United States)

    Chen, Shuang; Crother, Timothy R; Arditi, Moshe

    2010-01-01

    The IL-23-IL-17 axis is emerging as a critical regulatory system that bridges the innate and adaptive arms of the immune system. Th17 cells have been linked to the pathogenesis of several chronic inflammatory and autoimmune diseases. However, the role of Th17 cells and IL-17 in various stages of atherogenesis remains poorly understood and is only beginning to be elucidated. While IL-17 is a predominantly proinflammatory cytokine, it has a pleiotropic function and it has been implicated both as an instigator in the pathogenesis of several inflammatory disorders as well as being protective in certain inflammatory disease models. Therefore, it is not surprising that the current literature is conflicting on the role of IL-17 during atherosclerotic lesion development. Various approaches have been used by several groups to discern the involvement of IL-17 in atherosclerosis. While one study found that IL-17 is protective against atherosclerosis, several other recent studies have suggested that IL-17 plays a proatherogenic role. Thus, the function of IL-17 remains controversial and awaits more direct studies to address the issue. In this review, we will highlight all the latest studies involving IL-17 and atherosclerosis, including both clinical and experimental research.

  18. CIA小鼠血清中IL-27、IL-10、IL-17的动态分析%Dynamic changes of IL-27, IL-10, IL-17 in serum of collagen-induced arthritis in mice

    Institute of Scientific and Technical Information of China (English)

    郭亚春; 封桂英; 宋鸿儒; 邢恩鸿; 安高; 赵晓菲

    2015-01-01

    Objective:To observe chicken typeⅡcollagen-induced arthritis( CIA) in serum of mice with the dynamic changes of IL-27,IL-17,IL-10. Methods: 54 DBA1/J mice were randomly divided into control group(n=6) and model group(n=12), according to the progress of CIA mouse course early,middle and late(7,14,and 35 days after booster immunization) ,taking the eyeball for blood and separating the serum under sterile condition. The dynamic levels of cytokines IL-27,IL-17,IL-10 were detected by flow cy-tometry. Results:The level of IL-27 in the model group was significantly declined in the the progress of CIA mouse course early and middle(P 0. 05);the level of IL-17 in the disease early and late was no significant difference(P> 0. 05) compared with the control group,while in the mid course significantly higher than control group(P 0. 05). Conclusion: IL-27,IL-17,IL-10 paticipate in the pathogenesis of CIA and their alterations at different stages of the disease have a relation to the development of arthritis.%目的::观察鸡Ⅱ型胶原诱导型关节炎( CIA)小鼠血清中IL-27、IL-17、IL-10的动态变化。方法:54只DBA1/J小鼠随机分为对照组(每组6只)和模型组(每组12只),分别在CIA小鼠病程进展的早、中、晚期无菌摘眼球取血,常规分离血清,应用流式细胞术检测各组小鼠在疾病病程的早、中、晚期血清中细胞因子IL-27、IL-17、IL-10的动态变化情况。结果:模型组IL-27在疾病早期、中期显著下降(P0.05);模型组IL-17在疾病的早期及晚期与对照组比较无明显区别( P>0.05),而在病程中期显著高于对照组( P0.05)。结论:细胞因子IL-27和IL-17、IL-10可能参与CIA发病,可能与胶原诱导型关节炎的炎症进展有一定关系。

  19. Le droit à disposer de son temps. Manifeste pour les politiques temporelles territoriales Il diritto a disporre del proprio tempo. Un manifesto per le politiche tempo-territoriali

    Directory of Open Access Journals (Sweden)

    Chris Beyer

    2012-12-01

    Full Text Available Bien que les individus des sociétés modernes occidentales aient pour la plupart davantage de temps disponible et accès à des moyens de mobilités performants, ils éprouvent des difficultés croissantes dans leurs gestions du temps et de l'espace et notamment en termes d'articulation entre les différents temps et espaces sociaux. Les individus luttent pour réduire la pression temporelle au sein d'emploi du temps à flux tendus de plus en plus individualisés.

  20. Detection of the novel IL-1 family cytokines by QAH-IL1F-1 assay in rheumatoid arthritis.

    Science.gov (United States)

    Wang, M; Wang, B; Ma, Z; Sun, X; Tang, Y; Li, X; Wu, X

    2016-04-30

    The interleukin (IL)-1 family of cytokines comprises 11 members, including 7 pro-inflammatory cytokines (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β,IL-36γ) and 4 anti-inflammatory cytokines (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37 and IL-38), and play central roles in mediating immune responses. In this study, we detected serum levels of IL-36 subfamily cytokines (including IL-36α, IL-36β, IL-36γ, IL-36Ra and IL-38), IL-37, IL-33 and aimed to investigate the roles of these cytokines in rheumatoid arthritis (RA) preliminarily. A total of 10 RA patients and 10 healthy controls (HCs) were involved in this study, we measured IL-36 subfamily cytokines, IL-37 and IL-33 levels in the serum of the experiment subjects by QAH-IL1F-1 assay. Clinical and laboratory data of the subjects were collected and analyzed by Spearman's rank test. Compared to that of HCs, IL-36α, IL-36β, IL-36Ra, IL-38 and IL-33 levels were significantly increased in RA patients. We also found RA patients with elevated IL-36Ra had a higher ESR and RF-IgM, and there was a positive correlation between increased IL-36α and CRP. Our study suggests that parts of the novel members of IL-1 family cytokines were involved in the pathogenesis of RA, and may provide a novel target for therapies of RA.

  1. Barnaba Maj (ed., Il Gattopardo nel flusso del tempo. Il romanzo di Tomasi e il film di Visconti

    Directory of Open Access Journals (Sweden)

    Paola Fallerini

    2011-11-01

    Full Text Available Il Seminario di Teoria della Narrazione dell’Università di Bologna, organizzato e curato da Barnaba Maj, propone una analisi collettiva del romanzo di Lampedusa la cui riflessione si sofferma sul tempo interno alla narrazione e il tempo che travalica le coordinate del racconto e della collocazione storica. Il tempo si manifesta perciò come elemento pluridimensionale, all’interno del quale si impone la connotazione atemporale dello spazio mitico in stretta connessione con quello storico.

  2. The possible role of the novel cytokines il-35 and il-37 in inflammatory bowel disease.

    Science.gov (United States)

    Li, Yanmei; Wang, Yanan; Liu, Ying; Wang, Yatian; Zuo, Xiuli; Li, Yanqing; Lu, Xuefeng

    2014-01-01

    Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and inflamed mucosal levels in IBD patients. In 20 ulcerative colitis (UC) patients, 7 Crohn's disease (CD) patients, and 15 healthy subjects, cytokine levels in serum were determined using ELISA and mucosal expression studies were performed by immunohistochemistry, quantitative real-time PCR, and Western blot. The results showed that serums IL-35 and IL-37 levels were significantly decreased in UC and CD patients compared with healthy subjects. The cytokines levels correlated inversely with UC activity. IL-35 was expressed in infiltrating immune cells while IL-37 in intestinal epithelial cells as well as inflammatory cells. IBD patients had significantly higher Ebi3, p35 (two subunits of IL-35), and IL-37b gene expressions; IL-35 and IL-37 protein expressions were higher in IBD patients compared with controls. The study showed that serums IL-35 and IL-37 might be potentially novel biomarkers for IBD. Intestinal IL-35 and IL-37 proteins are upregulated, suggesting that regulating the expression of the two cytokines may provide a new possible target for the treatment of IBD.

  3. 25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

    Directory of Open Access Journals (Sweden)

    Anna Bonanno

    2014-01-01

    Full Text Available Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways. 25-Hydroxyvitamin D [25(OH Vit D], IL-31, and IL-33 plasma levels were measured in 28 controls (HC, 11 allergic rhinitis (AR patients, and 35 allergic asthma with rhinitis (AAR patients. We found significant lower levels of 25(OH Vit D in AR and in AAR than in HC. IL-31 and IL-33 plasma levels significantly increased in AAR than HC. IL-31 and IL-33 positively correlated in AR and AAR. 25(OH Vit D deficient AAR had higher levels of blood eosinophils, exacerbations, disease duration, and total IgE than patients with insufficient or sufficient 25(OH Vit D. In AAR 25(OH Vit D levels inversely correlated with total allergen sIgE score and total atopy index. IL-31 and IL-33 did not correlate with 25(OH Vit D in AR and AAR. In conclusion, low levels of 25(OH Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity.

  4. IL-15 deficient tax mice reveal a role for IL-1α in tumor immunity.

    Directory of Open Access Journals (Sweden)

    Daniel A Rauch

    Full Text Available IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time. To identify the role of IL-15 in spontaneous development of lymphoma in vivo, an IL-15(-/- TAX-LUC strain was developed and examined. The absence of IL-15 resulted in aggressive tumor growth and accelerated mortality and demonstrated that IL-15 was not required for Tax-mediated lymphoma but was essential for anti-tumor immunity. Further analysis revealed a unique transcriptional profile in tumor cells that arise in the absence of IL-15 that included a significant increase in the expression of IL-1α and IL-1α-regulated cytokines. Moreover, anti-IL-1α antibodies and an IL-1 receptor antagonist (Anakinra were used to interrogate the potential of IL-1α targeted therapies in this model. Taken together, these findings identify IL-15 and IL-1α as therapeutic targets in lymphoma.

  5. IL-15 and IL-17F are differentially regulated and expressed in mycosis fungoides (MF)

    DEFF Research Database (Denmark)

    Willerslev-Olsen, Andreas; Litvinov, Ivan V; Fredholm, Simon M

    2014-01-01

    Skin lesions from mycosis fungoides (MF) patients display an increased expression of interleukin-15 (IL-15), IL-17F, and other cytokines implicated in inflammation and malignant cell proliferation in cutaneous T-cell lymphoma (CTCL). In the leukemic variant of CTCL, Sézary syndrome (SS), IL-2...... and IL-15 trigger activation of the Jak-3/STAT3 pathway and transcription of IL17A gene, whereas it is unknown what causes IL-15 expression, Jak3/STAT3 activation, and production of IL-17F in MF. Here, we studied the expression and regulation of IL-15 and its relation to IL-17F in MF cell lines and skin......-malignant MF T cells, whereas the spontaneous STAT3 activation and IL-17F expression in malignant T cells is not inhibited; (3) patients display heterogeneous IL-15/IL-17F mRNA expression patterns in skin lesions; and (4) IL-15 expression (in contrast to IL-17F) is not associated with progressive disease...

  6. Interleukin newcomers creating new numbers in rheumatology: IL-34 to IL-38.

    Science.gov (United States)

    Clavel, Gaëlle; Thiolat, Allan; Boissier, Marie-Christophe

    2013-10-01

    The development of innovative technologies is steadily increasing the body of knowledge on molecules involved in physiological functions. Thus, several interleukins (ILs) have been identified and characterized in the past few years. Here, we detail the structural and functional characteristics of IL-34 to IL-38 with special attention to their involvement in inflammatory joint disease. IL-34 chiefly increases osteoclast activation and proliferation and therefore, it plays a direct role in bone destruction as seen in rheumatoid arthritis (RA). Regulatory T-cells (Tregs) express IL-35, which therefore exerts anti-inflammatory effects by restoring Treg suppressive capabilities and by inhibiting the Th17 pathway. IL-37 has anti-inflammatory effects mediated by a negative feedback loop that decreases the release of pro-inflammatory cytokines. IL-36 belongs to the IL-1 family and has three different forms. Although this cytokine has been chiefly studied in psoriasis and psoriatic arthritis, it also exerts pro-inflammatory effects in RA. The specific IL-36 antagonist, IL-36Ra binds to the IL-36 receptor, thereby, preventing signal transduction. Finally, IL-38 is a recently identified cytokine whose effect may resemble that of IL-36Ra as it binds to the IL-36 receptor and inhibits its effects, particularly the Th17-response. Although the exact roles for these cytokines awaits elucidation, the current improvements in our knowledge of the mechanisms that regulate chronic inflammatory conditions, such as RA may lead to the identification of new treatment targets.

  7. IL-15 deficient tax mice reveal a role for IL-1α in tumor immunity.

    Science.gov (United States)

    Rauch, Daniel A; Harding, John C; Ratner, Lee

    2014-01-01

    IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL) and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time. To identify the role of IL-15 in spontaneous development of lymphoma in vivo, an IL-15(-/-) TAX-LUC strain was developed and examined. The absence of IL-15 resulted in aggressive tumor growth and accelerated mortality and demonstrated that IL-15 was not required for Tax-mediated lymphoma but was essential for anti-tumor immunity. Further analysis revealed a unique transcriptional profile in tumor cells that arise in the absence of IL-15 that included a significant increase in the expression of IL-1α and IL-1α-regulated cytokines. Moreover, anti-IL-1α antibodies and an IL-1 receptor antagonist (Anakinra) were used to interrogate the potential of IL-1α targeted therapies in this model. Taken together, these findings identify IL-15 and IL-1α as therapeutic targets in lymphoma.

  8. The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease

    Directory of Open Access Journals (Sweden)

    Yanmei Li

    2014-01-01

    Full Text Available Interleukin- (IL- 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD patients have not been yet explored. Our aim was to evaluate serum and inflamed mucosal levels in IBD patients. In 20 ulcerative colitis (UC patients, 7 Crohn’s disease (CD patients, and 15 healthy subjects, cytokine levels in serum were determined using ELISA and mucosal expression studies were performed by immunohistochemistry, quantitative real-time PCR, and Western blot. The results showed that serums IL-35 and IL-37 levels were significantly decreased in UC and CD patients compared with healthy subjects. The cytokines levels correlated inversely with UC activity. IL-35 was expressed in infiltrating immune cells while IL-37 in intestinal epithelial cells as well as inflammatory cells. IBD patients had significantly higher Ebi3, p35 (two subunits of IL-35, and IL-37b gene expressions; IL-35 and IL-37 protein expressions were higher in IBD patients compared with controls. The study showed that serums IL-35 and IL-37 might be potentially novel biomarkers for IBD. Intestinal IL-35 and IL-37 proteins are upregulated, suggesting that regulating the expression of the two cytokines may provide a new possible target for the treatment of IBD.

  9. Study on Cytokines IL-2, IL-6, IL-10 in Patients of Chronic Allergic Rhinitis Treated with Acupuncture

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objectives: To observe the plasmatic concentration of IL-6, IL-10 and IL-2 in the patient of chronic allergic rhinitis before and after acupuncture therapy. Methods: Cytokine levels were determined before and after treatment in 30 healthy volunteers (Group A) and 90 patients of chronic allergic rhinitis (Group B) with an increased plasma IL-10 level. Group B was then divided into 3 subgroups: 30 patients treated with real acupuncture (Group B1); 30 patients treated with sham acupuncture (Group B2); 30 non-treated patients (Group B3). Results: The allergic subjects of group B1, compared with controls, showed a significant reduction of IL-10 after a specific treatment with acupuncture (P<0.05). On the other hand, in those patients treated with sham acupuncture (B2) as well as in non-treated patients (B3), the IL-10 values remained high and unchanged. There was a statistically significant change in IL-2 values at 24 hours (P<0.05) after real acupuncture (Groups A, B1), however the values remained within normal ranges. The IL-6 do not change after therapy. Conclusion: The acupuncture treatment can reduce plasmatic level of IL-10 in chronic allergic rhinitis.

  10. [Value of IL-6 and IL-8 in the diagnosis of neonatal sepsis].

    Science.gov (United States)

    Zhao, Feng-Xia; Liu, Guang-Hui; Zhang, Jian

    2015-12-01

    To explore the significance of interleukin-6 (IL-6) and IL-8 in the diagnosis of neonatal sepsis. This was a prospective study conducted between August 2014 and February 2015. A total of 140 neonates who were suspected infectious were enrolled and classified into a sepsis group (n=49) and a local infection group (n=91). Sixty-one neonates who were non-infectious served as the control group. Serum levels of IL-6 and IL-8 were measured before treatment and 3 days after treatment. The value of serum IL-6 and IL-8 for the diagnosis of neonatal sepsis was assessed by receiver operating characteristic (ROC) curve analysis. Before treatment, serum levels of IL-6 and IL-8 in the sepsis group were higher than those in the local infection and control groups (Psepsis group remained higher than that in the local infection and control groups (Pneonatal sepsis were 87.8%, 79.6% and 81.6% respectively; when the cut-off value of serum IL-8 was 54 pg/mL, the sensitivity, specificity and accuracy of serum IL-6 for the diagnosis of neonatal sepsis were 77.6%, 63.8% and 67.2% respectively. With the combination of serum IL-6 and IL-8 levels, the sensitivity, specificity and accuracy for the diagnosis of neonatal sepsis were 71.4%, 86.2% and 82.6% respectively. IL-6 and IL-8 participate in the inflammatory response and the serum levels of both vary with the severity of infection. The diagnostic value of IL-6 for neonatal sepsis is higher than IL-8. The combined detection of serum levels IL-6 and IL-8 may increase the accuracy of diagnosis of neonatal sepsis.

  11. Il Gambling Compulsivo: rilevanza epidemiologica

    Directory of Open Access Journals (Sweden)

    A. Coacci

    2003-05-01

    Full Text Available

    Introduzione: il gioco d’azzardo ha profonde radici nella storia e nella cultura di ogni popolo. Si stima che circa l’80% della popolazione adulta nel nostro Paese giochi d’azzardo. Esso, pur rappresentando per la maggior parte di queste persone solo un innocuo passatempo, si trasforma talora in una vera e propria malattia (gambling compulsivo, con comportamenti che denotano forme estreme di rischio, sino a forme che portano alla distruzione della famiglia e persino della propria vita.

    Si tratta un disturbo poco conosciuto e spesso non diagnosticato. Infatti, benché sia largamente diffuso e comporti rilevanti costi umani e sociali, il gambling compulsivo solo di recente è stato incluso nelle classificazioni diagnostiche internazionali.

    Obiettivi: valutare l’impatto epidemiologico del gambling compulsivo (gioco d’azzardo patologico in una ASL/provincia.

    Materiali e metodi: è stato inviato un questionario ai 190 Medici di Medicina Generale della provincia di Grosseto (ASL 8, per raccogliere informazioni su: sistema di cura, numero di soggetti che si sono rivolti al proprio medico di famiglia per tale problema, eventuale coesistenza di problemi e comportamenti di dipendenza e di abuso (alcool, psicofarmaci, droghe illegali, ecc.

    Risultati: sono pervenuti 127 (pari al 66,8% questionari compilati. L’elaborazione dei dati è tuttora in corso.

    Conclusioni: dai risultati preliminari sembra emergere che il numero di persone che chiede aiuto al medico e al SSN, differentemente da quanto accade per i tossicodipendenti, è molto limitato e, quindi, intuitivamente poco indicativo della massa di soggetti realmente coinvolti dalla problematica studiata. Si discute del ruolo nella promozione della salute potenzialmente svolto dai Medici di Medicina Generale. Per quanto la tecnica di rilevazione appaia relativamente poco sensibile

  12. Autophagy and IL-1 family cytokines

    Directory of Open Access Journals (Sweden)

    James eHarris

    2013-04-01

    Full Text Available Autophagy is an important intracellular homeostatic mechanism for the targeting of cytosolic constituents, including organelles, for lysosomal degradation. Autophagy plays roles in numerous physiological processes, including immune cell responses to endogenous and exogenous pathogenic stimuli. Moreover, autophagy has a potentially pivotal role to play in the regulation of inflammatory responses. In particular, autophagy regulates endogenous inflammasome activators, as well as inflammasome components and pro-IL-1β. As a result, autophagy acts a key modulator of IL-1β and IL-18, as well as IL-1α, release. This review focuses specifically on the role autophagy plays in regulating the production, processing and secretion of IL-1 and IL-18 and the consequences of this important function.

  13. Autophagy and IL-1 Family Cytokines.

    Science.gov (United States)

    Harris, James

    2013-01-01

    Autophagy is an important intracellular homeostatic mechanism for the targeting of cytosolic constituents, including organelles, for lysosomal degradation. Autophagy plays roles in numerous physiological processes, including immune cell responses to endogenous and exogenous pathogenic stimuli. Moreover, autophagy has a potentially pivotal role to play in the regulation of inflammatory responses. In particular, autophagy regulates endogenous inflammasome activators, as well as inflammasome components and pro-IL-1β. As a result, autophagy acts a key modulator of IL-1β and IL-18, as well as IL-1α, release. This review focuses specifically on the role autophagy plays in regulating the production, processing, and secretion of IL-1 and IL-18 and the consequences of this important function.

  14. Dirac e il monopolo magnetico

    CERN Document Server

    Aloisi, A M

    2016-01-01

    In 1931, Dirac advanced a startling prediction about the existence of a new elementary particle, characterized by a magnetic charge of a single polarity: the magnetic monopole. This prediction, that was not based on experimental reasons but on mathematical consistency considerations and the generalization of the formalism of quantum mechanics, illustrates emblematically the Dirac conception of the relationship between physics and mathematics. ----- Nel 1931 Dirac avanz\\`o una sorprendente previsione circa l'esistenza di una nuova particella elementare, caratterizzata da una carica magnetica di un'unica polarit\\`a: il monopolo magnetico. Questa previsione, che non era fondata su ragioni sperimentali ma su considerazioni di consistenza matematica e sulla generalizzazione del formalismo della meccanica quantistica, illustra emblematicamente la concezione di Dirac del rapporto tra fisica e matematica.

  15. Il fuoco della fusione termonucleare controllata

    CERN Document Server

    Caldirola, Piero; Sindoni, Elio

    1984-01-01

    Per realizzare la fusione termonucleare controllata, cioè catturare e dominare il fuoco che accende gli astri, e ottenere così una nuova fonte di energia praticamente illimitata e a basso costo, si richiede uno sforzo collettivo e unitario globale: non esiste infatti nazione al mondo che sia in grado, singolarmente presa, di affrontare il problema, sia per le risorse finanziarie necessarie all'impresa sia per il numero dei ricercatori che dovranno dedicarvisi.

  16. Comparing IL-5, IL-10, IL-12, and IL-18 Cytokines Levels Secreted From the PBMCs of Patients with Healing and Nonhealing Skin Leishmaniasis

    Directory of Open Access Journals (Sweden)

    S.M.J. Yazdanpanah

    2009-10-01

    Full Text Available Introduction & Objective: Leishmaniasis is a major worldwide health problem throughout the world and in Iran as well. Skin lesions are mostly healing but nonhealing cases have also increased recently. T-helper type1 (Th1 responses induction helps the patients to resist against the disease while T-helper type2 (Th2 responses cause susceptibility to disease. With the assessment of IL-5, IL-10, IL-12, and IL-18 cytokines secreted from peripheral blood mononuclear cells (PBMC in leishmaniasis healing and nonhealing patients, their role in curing leishmaniasis was surveyed.Materials & Methods: Cytokines secreted from PBMCs of 60 healing and nonhealing patients and also control group referred to Ab-o-Bargh number1 clinic and Mashhad Qaem hospital during 2007 were evaluated Elisa commercial kits after stimulation by leishmania antigen and mitogen in vitro. Results: Healing patients PBMCs secreted IL-12 (236.55±38.00 pg/ml more than non healing patients (p<0.05 while in nonhealing patients IL-5 (52.14±65.21 pg/ml and IL-10 (30.19±18.73 pg/ml secreted more than healing patients (p<0.005. Also IL-18 secreted significantly higher in nonhealing patients compared with healing patients (p=0.003.Conclusion: According to the results It can be concluded that IL-12 is secreted more in healing patients than nonhealing patients but IL-18, which causes the increase of IL-12 secretion and the activation of Th1 cells during IL-12 secretion decrease, secrets more in nonhealing patients, induces Th2 responses and results in disease progression.

  17. IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures

    DEFF Research Database (Denmark)

    Blom, Lars; Poulsen, Lars K.

    2012-01-01

    The IL-1 family members IL-1ß, IL-18, and IL-33 are potent cytokines in relationship to amplifying the CD4(+) T cell cytokine production. To evaluate their impact on in vitro-differentiated human Th1 and Th2 cultures, such cultures were established from naive T cells, purified from healthy blood...... donors, and reactivated in the presence of IL-1ß, IL-18, or IL-33. Interestingly, we observe modifying responses in Th1 and Th2 cultures induced by IL-18 or IL-33 but not by IL-1ß, both contributing to amplify production of IL-5, IL-13, and IFN-¿. IL-18 or IL-33 stimulation of Th1 cultures resulted...... in increased IFN-¿ and IL-13 production concurrent with reduced IL-10 gene transcription and secretion even though Th1 cultures, in contrast to IL-18Ra, had low ST2L expression. Furthermore, adding IL-18 to Th1 cultures promoted Tbet mRNA expression and production. Th2 cultures stimulated with IL-18 or IL-33...

  18. DMPD: Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15546391 Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Watf...html) (.csml) Show Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. PubmedID 15546391 T...itle Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Author

  19. Producción y percepción de bienes públicos en la lógica de la acción colectiva

    Directory of Open Access Journals (Sweden)

    Jordana, Jacint

    2007-04-01

    Full Text Available Public goods having different proprieties produce different problems of collective action. This hypothesis has been discussed from different analytical perspectives and we examine their arguments, aiming to deepen our theoretical understanding about the logic of collective action. In this paper we look for similarities and differences regarding their use of concepts and expected results. Simultaneously, we examine the link between different public goods and the interdependent behavior of individuals. To this purpose, we also revisit the connections between production functions and consumption types in the case of public goods, as a mean to explore the potential development of more elaborated models in the theory of collective action, and suggest that more empirical contrast of these models is needed. Finally, we argue the importance for theoretical discussions to include a discussion about the impact of perception in the collective action models, considering systematic deviations to rational choice, and conclude that no single theory may address all collective action problems, but systematic patterns of behavior may be identified and empirically confirmed.

    Bienes públicos con distintas propiedades generan problemas diferentes de acción colectiva. Esta hipótesis ha sido discutida, desde distintas perspectivas analíticas, con el objeto de profundizar teóricamente sobre la lógica de la acción colectiva. En este trabajo se revisan las aportaciones recientes a esta cuestión, analizando sus puntos de encuentro y sus divergencias en cuanto a conceptos y resultados esperados. Asimismo, se examina la relación entre tipos distintos de bienes públicos y el comportamiento interdependiente de los individuos. Con este fin, los vínculos entre las funciones de producción y las formas de consumo de bienes públicos también son considerados, ya que permite desarrollar modelos más ambiciosos sobre la lógica de la acción colectiva. Finalmente

  20. La opacidad de los acuerdos generales de bienes y servicios en España Opacity of general agreements on goods and services in Spain

    Directory of Open Access Journals (Sweden)

    Román Andrés Umaña Peña

    2006-06-01

    Full Text Available Objetivo: Explorar la intensidad del debate parlamentario sobre el Acuerdo General de Comercio de Servicios (AGCS asumido por España ante la Organización Mundial del Comercio (OMC, y compararla con la del Acuerdo General de Bienes (GATT. Métodos: Búsqueda sistemática y análisis del contenido de todas las iniciativas parlamentarias sobre AGCS y GATT realizadas entre 1979 y 2004 en el Congreso de los Diputados y el Senado. Se calculó la frecuencia y porcentaje de iniciativas parlamentarias de ambos temas, resultado de su tramitación y tipo de iniciativa. Resultados: Se presentaron 185 iniciativas parlamentarias sobre los acuerdos multilaterales de bienes y servicios, de las que 120 se referían al GATT, 8 al AGCS y 57 a ambos acuerdos. La mayoría de las iniciativas no fueron discutidas (GATT, 71%; GATS, 55,4% o estuvieron sujetas a un debate político en el que apenas se dieron intervenciones por parte de los grupos parlamentarios. Conclusiones: A pesar de las implicaciones del acuerdo multilateral de servicios para la política sanitaria española, éste se ha asumido con escaso debate parlamentario previo, incluso menos que en el caso de su homólogo sobre bienes. Se requiere en este tema una intensificación de la función de control al gobierno.Objective: To explore the intensity of the debate in the Spanish Parliament on the General Agreement on Trade in Services (GATS developed by Spain and the World Trade Organization, and to compare it with the debate on the General Agreement on Tariffs and Trade (GATT. Methods: A systematic search and content analysis were performed of all parliamentary initiatives on GATS and GATT undertaken from 1979 to 2004 in the Spanish Parliament and Senate. The frequency and percentages of initiatives on both issues were calculated, and the final result and kinds of initiative were analyzed. Results: A total of 185 initiatives were presented in the Spanish Parliament on these agreements, of which 120 were

  1. Il Fuori Scala tra Occidente e Oriente

    OpenAIRE

    SCARONI, FEDERICO

    2009-01-01

    Tutto può essere fuori scala, nulla può esserlo. Il parametro di riferimento è tutto. Può, il fuori scala, avere la stessa valenza per tutti gli ambiti e gli osservatori, stante il parametro di riferimento come chiave di lettura? Può il fuori scala oggi, continuare a essere una modalità progettuale coerente? Questa ricerca nasce dal desiderio di fornire chiarezza in un ambito della composizione apparentemente limpido e cristallino, nelle sue implicazioni nel moderno-contemporaneo ...

  2. Systemic IL-17 after severe injuries.

    Science.gov (United States)

    Frangen, Thomas M; Bogdanski, Denise; Schinkel, Christian; Roetman, Bernd; Kälicke, Thomas; Muhr, Gert; Köller, Manfred

    2008-04-01

    IL-17 is a cytokine produced by a newly identified T-cell subpopulation (THl7/THIL-17). It is a central mediator in inflammatory processes that connects T-cell stimulation with neutrophil mobilization. The role of IL-17 in the immune dysfunction after polytrauma is still not clarified. In a retrospective study, the systemic concentration of IL-17 and IL-6 of 71 polytraumatized patients were analyzed daily by enzyme-linked immunosorbent assay. The patients' collective consist of 55 men and 16 women (43 +/- 16 years; injury severity score, 33 +/- 13). In only 6% of the patients, an increase in systemic IL-17 was detected. In most patients (94%), no systemic IL-17 was detectable or the IL-17 concentrations in plasma were in the range of the healthy donor group. To identify a possible role of systemic IL-17 in the posttraumatic phase, the patients were divided into two groups. Group A (47 men, 15 women) consists of patients with IL-17 concentrations in the range of normal healthy donors. Group B (8 men, 1 woman) consists of patients with elevated (>45 pg ml(-1) on at least 3 consecutive days) systemic IL-17 concentrations. Three patients in group B showed highly increased systemic IL-17 concentrations (median, >200 pg mL(-1)). These patients were male and showed all blunt chest and abdominal trauma with lung contusion and pneumohemothorax. However, there was no conformity in other injury patterns, injury severity score, age, outcome, intensive care period, or clinical complications. After a period of 4 years, we were able to obtain a new blood sample from one patient with high IL-17 level. The systemic IL-17 value of this former patient was now less than the detection limit. However, stimulation of peripheral blood mononuclear cells from thlise patient revealed elevated numbers of cells with the capacity to produce IL-17 as determined by enzyme-linked immuno spot assay and flow cytometry compared with peripheral blood mononuclear cells obtained from current polytrauma

  3. Il caso Lautsi contro l’Italia

    Directory of Open Access Journals (Sweden)

    Grégor Puppinck

    2012-02-01

    SOMMARIO: 1. Premesse – 2. Il ragionamento della Seconda Sezione - 2.1. La ridefinizione dalla finalità del sistema educativo pubblico - 2.2. Il pluralismo educativo come finalità – 2.3. Sintesi del ragionamento della Sezione – 2.4.  Una sentenza contestata - 3.  Il ragionamento sviluppato dalla Grande Camera - 3.1. La sussidiarietà e il margine di apprezzamento – 3.2.  Il laicismo è una convinzione filosofica non neutra – 3.3. La neutralità si applica all’ “agire” e non all' "essere” dello  Stato – 3.4.  Democrazia, neutralità confessionale e laicità – 3.5.  L’educazione pubblica  nel senso della Grande Camera – 3.6.  Il crocefisso: un simbolo passivo – 3.7.  L’assenza d’ingerenza dello Stato - 4.  Gli sviluppi supplementari alla sentenza della Grande Camera – 4.1.  Il crocefisso e il velo islamico – 4.2.  La libertà negativa di religione dei non credenti – 4.3. La falsa soluzione bavarese – 4.4.  La tradizione – 4.5. La religione maggioritaria – 4.6.  Il dibattito religioso e politico – 4.7. Le conseguenze del caso Lautsi.

  4. Legge professioni: il commento di Ordine Psicologi

    Directory of Open Access Journals (Sweden)

    Mauro Grimoldi

    2013-01-01

    Full Text Available E oggi mi invento una professione... Di per sé il decreto 3270 "in materia di professioni non regolamentate in Ordini o collegi" introduce il seme, o se si vuole il germe, di un'iniziativa autonoma in merito alle professioni. E forse, da un certo punto di vista, ci voleva. Serve, nell'intendimento del legislatore, a sanare il caso degli informatici e degli amministratori di condominio, ad oggi privi di regolamentazione, di percorsi formativi e di carte etiche da rispettare. Dunque, bene? Non proprio tutto.

  5. Sinergetica il segreto del successo della natura

    CERN Document Server

    Haken, Hermann

    1983-01-01

    Introduzione e sommario ; il disordine cresce sempre? la morte termica dell'universo ; i cristalli : strutture ordinate, ma morte ; strutture ordinate nei liquidi e nelle nubi e formazioni geologiche ; fiat lux! la luce del laser ; configurazioni chimiche ; l'evoluzione biologica e la sopravvivenza del migliore ; sopravvivi anche senza essere il migliore : specializzati, scavati una nicchia ecologica ; come si formano gli organismi biologici ; talvolta i conflitti sono ineluttabili ; il caos, il caso e la concezione meccanicistica del mondo ; gli effetti sinergetici nell'economia ; si possono prevedere le rivoluzioni ? ; le allucinazioni comprovano le teorie sul cervello.

  6. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor.

    Science.gov (United States)

    Suzukawa, Maho; Iikura, Motoyasu; Koketsu, Rikiya; Nagase, Hiroyuki; Tamura, Chise; Komiya, Akiko; Nakae, Susumu; Matsushima, Kouji; Ohta, Ken; Yamamoto, Kazuhiko; Yamaguchi, Masao

    2008-11-01

    Basophils are thought to play pivotal roles in allergic inflammation through rapid release of chemical mediators in addition to sustained production of Th2 cytokines, including IL-4. A newly identified cytokine, IL-33, has been recognized as one of the key cytokines enhancing Th2-balanced immune regulation through its receptor, ST2. The present study was conducted to elucidate whether IL-33 acts directly on, and affects the functions of, human basophils. Real-time PCR analysis showed that basophils express transcripts for ST2. The expression levels were significantly higher compared with eosinophils and neutrophils, and treatment with IL-33 significantly up-regulated basophil ST2 mRNA expression. Expressions of IL-4 and IL-13 mRNA were also up-regulated by IL-33, and there was also enhanced secretion of IL-4 protein. IL-33 increased the surface levels of basophil CD11b expression and enhanced basophil adhesiveness. Although IL-33 failed to directly induce degranulation or attract basophils, it exerted priming effects on basophils. It enhanced degranulation in response to IgE-crosslinking stimulus and also enhanced basophil migration toward eotaxin without changing surface CCR3. Also, IL-33 synergistically enhanced IL-4 production and CD11b expression by IL-3-stimulated basophils. Neutralization using Ab specific for ST2 significantly diminished the enhancing effects of IL-33 on both basophil CD11b expression and migration toward eotaxin, indicating that IL-33 signals via ST2 expressed on basophils. This study revealed that IL-33 potently regulates migration and activation of human basophils. IL-33 may be a key cytokine in the pathogenesis of Th2-dominant inflammation by acting not only on lymphocytes but also on effector cells such as basophils.

  7. Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases

    Directory of Open Access Journals (Sweden)

    Gabriele Fenini

    2017-05-01

    Full Text Available In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs. Activation of the inflammasomes results in the processing and subsequent secretion of the pro-inflammatory cytokines IL-1β and IL-18. Several autoinflammatory disorders such as cryopyrin-associated periodic syndromes and Familial Mediterranean Fever have been associated with mutations of genes encoding inflammasome components. Moreover, the importance of IL-1 has been reported for an increasing number of autoinflammatory skin diseases including but not limited to deficiency of IL-1 receptor antagonist, mevalonate kinase deficiency and PAPA syndrome. Recent findings have revealed that excessive IL-1 release induced by harmful stimuli likely contributes to the pathogenesis of common dermatological diseases such as acne vulgaris or seborrheic dermatitis. A key pathogenic feature of these diseases is IL-1β-induced neutrophil recruitment to the skin. IL-1β blockade may therefore represent a promising therapeutic approach. Several case reports and clinical trials have demonstrated the efficacy of IL-1 inhibition in the treatment of these skin disorders. Next to the recombinant IL-1 receptor antagonist (IL-1Ra Anakinra and the soluble decoy Rilonacept, the anti-IL-1α monoclonal antibody MABp1 and anti-IL-1β Canakinumab but also Gevokizumab, LY2189102 and P2D7KK, offer valid alternatives to target IL-1. Although less thoroughly investigated, an involvement of IL-18 in the development of cutaneous inflammatory disorders is also suspected. The present review describes the role of IL-1 in diseases with skin involvement and gives an overview of the relevant studies discussing the therapeutic potential of modulating the secretion and activity of IL-1 and IL-18 in such diseases.

  8. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria

    Directory of Open Access Journals (Sweden)

    Akiko Shibui

    2016-03-01

    Full Text Available IL-25, IL-33 and TSLP, which are produced predominantly by epithelial cells, can induce production of Th2-type cytokines such as IL-4, IL-5 and/or IL-13 by various types of cells, suggesting their involvement in induction of Th2-type cytokine-associated immune responses. It is known that Th2-type cytokines contribute to host defense against malaria parasite infection in mice. However, the roles of IL-25, IL-33 and TSLP in malaria parasite infection remain unclear. Thus, to elucidate this, we infected wild-type, IL-25−/−, IL-33−/− and TSLP receptor (TSLPR−/− mice with Plasmodium berghei (P. berghei ANKA, a murine malaria strain. The expression levels of IL-25, IL-33 and TSLP mRNA were changed in the brain, liver, lung and spleen of wild-type mice after infection, suggesting that these cytokines are involved in host defense against P. berghei ANKA. However, the incidence of parasitemia and survival in the mutant mice were comparable to in the wild-type mice. These findings indicate that IL-25, IL-33 and TSLP are not critical for host defense against P. berghei ANKA.

  9. Upregulated IL-21 and IL-21 receptor expression is involved in experimental autoimmune uveitis (EAU).

    Science.gov (United States)

    Liu, Lan; Xu, Yongfeng; Wang, Jianyong; Li, Huiyan

    2009-12-31

    Interleukin (IL)-21 has recently been shown to play a vital role in the development of many autoimmune diseases. Our study is designed to investigate the alteration and possible function of IL-21 in the development of an experimental autoimmune uveitis (EAU) model. EAU was induced in B10.RIII mice by subcutaneous injection of interphotoreceptor retinoid-binding protein (IRBP) 161-180 emulsified with complete Freund's adjuvant (CFA) and evaluated by clinical and histopathologic observation. IL-21 and IL-21R mRNA expressions in cells of draining lymph node (DLN) and spleen in EAU and control mice were determined by reverse transcription-PCR. The frequencies of interleukin-21 receptor positive cells were also examined using flow cytometry. IL-17 levels in the supernatant of the cell culture upon IL-21 stimulation were assayed by enzyme-linked immunosorbent assay. Results showed that EAU was successfully induced by IRBP161-180. Expression of IL-21 mRNA was significantly increased in cells of DLN and spleen in EAU compared with recovery phase mice and normal controls. IL-21R was also found upregulated in DLN and spleen cells of EAU mice by reverse transcription-PCR and flow cytometry. Cells in EAU cultured with IL-21 combined with transforming growth factor-beta induced increased production of IL-17. The findings revealed that increased IL-21 and IL-21R expression may be involved in the development of EAU, possibly by promoting IL-17 secretion.

  10. Il processo di cambiamento nelle pubbliche amministrazioni e il percorso verso l'eccellenza: il caso del comune di Pisa

    OpenAIRE

    Stile, Concetta

    2014-01-01

    2011 - 2012 La ricerca si propone di analizzare, attraverso lo studio di un caso pratico riguardante una Amministrazione Comunale italiana che ha intrapreso con successo il percorso verso l'eccellenza utilizzando il Common Assessment framework, gli innumerevoli processi di riforma che hanno investito la pubblica amministrazione nel suo complesso... [a cura dell'autore] XI n.s.

  11. 过敏性哮喘患者外周血IL-2、IL-4、IL-6和IL-8水平的变化%Change of the Level of IL-2, IL-4, IL-6 and IL-8 of Irritability Asthma Patients

    Institute of Scientific and Technical Information of China (English)

    王爱华; 李全新

    2000-01-01

    为了观察白细胞介素在哮喘发病中的作用,该文分别对哮喘发作期20例 ,缓解期12例患者及正常对照组10例进行了血清IL-2、IL-4、IL-6和IL-8的测定,结果发现 ,发作期患者血清IL-2水平下降,而IL-4、IL-6和IL-8水平均增高,缓解期均恢复至正常水平.提示这些细胞因子在哮喘发病过程中起着重要作用.

  12. THE CHANGES OF IL-1β AND IL-6 LEVEL AT DIFFERENT ALTITUDE AND THEIR SIGNIFICANCE

    Institute of Scientific and Technical Information of China (English)

    Jia Mian; Geng Paili; Zhu Haihong; Wu Hongfu

    2006-01-01

    Objective To investigate the changes of the concentration of interkeukine β 1(IL-1β) and Interleukine 6(IL-6) in the serum of the people who live in the different altitude, and try to find the relation between the cytokines (CK) and the hypoxia adaptation and some diseases caused by hypoxia. Methods Using enzyme linked immunoabsorbent assay (ELISA) to detect the level of the concentration of IL-1β and IL-6 in the serum. Results The concentration of IL-1β showed significant increase in values (P<0.05) at 4050m. IL-6 in same altitude showed obvious changes as well (P<0.05). Conclusion The results showed that the concentration of IL-1β and IL-6 have significant changes in the serum. This means that they may be involved in the process of the adaptation and some sickness because of hypoxia.

  13. Importance of IL-10 and IL-17 cytokines in human asthma as studied ...

    African Journals Online (AJOL)

    McRoy

    Importance of IL-10 and IL-17 cytokines in human asthma as studied by ELISPOT ... Detection of cytokines and other functional assays can be used to evaluate an immune ..... differentiate into memory cells with specific cytokine producing or ...

  14. Change of IL-1β, IL-6, IL-8 ,TNF-α, IL-10 in cerebrospinal fluid after brain injury and its clinical significance%脑外伤患者脑脊液IL-1β、IL-6、IL-8、TNF-α、IL-10水平变化及临床意义

    Institute of Scientific and Technical Information of China (English)

    吕丽霞; 张玲; 韩媛; 张国栋; 李巍; 杨萍; 张飚

    2013-01-01

    目的 探讨脑外伤时不同时期脑脊液IL-1β、IL-6、IL-8、TNF-α、IL-10的水平变化及临床意义.方法 选择48例脑外伤患者,其中重型26例、轻型22例;高颅内压25例、低颅内压23例.分别留取伤后12、24、36、72 h的脑脊液标本,采用酶联免疫吸附法检测伤后各时间点脑脊液IL-1β、IL-6、IL-8、TNF-α、IL-10水平.另取查体健康者28例为对照组.结果 与对照组相比,脑外伤患者脑脊液中IL-6、IL-1β、TNF-α、IL-8和IL-10水平均显著增高(P均<0.01).脑外伤重型组脑脊液IL-6、IL-1β、TNF-α和IL-8峰值水平高于与轻型组(P均<0.01);高颅内压组脑脊液中IL-1β峰值水平高于低颅内压组(P<0.01).结论 脑外伤后脑脊液炎性细胞因子水平升高,可作为预测脑损伤严重程度的指标.%Objective To investigate the concentration change of the inflammatory cytokines (IL-1 β,IL-6,IL-8,TNF-α,IL-10) in cerebrospinal fluid at different periods of time after traumatic brain injury.Methodds In this study,48 patients with traumatic brain injury were enrolled,the cerebrospinal fluid samples were collected in 12 h,24 h,36 h and 72 h after traumatic brain injury,the concentration of the inflammatory cytokines were detected with enzyme-linked immunosorbent assay.Results Compared with that in control group,there were significantly increased concentrations of IL-1 β,IL-6,IL-8,TNF-α,IL-10 in patients with traumatic brain injury(all P < 0.01).Peak concentrations of IL-6,IL-1 β,TNF-α and IL-8 of cerebrospinal fluid in patients with severe brain injury were significantly higher than those in patients with mild brain injury(all P < 0.01).Peak concentration of IL-1 β in patients with high intracranial pressure was higher than that in patients with low intracranial pressure(P <0.01).Conclusion The levels of IL-1 β,IL-6,IL-8,TNF-α and IL-10 increase after the traumatic brain injury,which may be one of the probable biomarkers for the severity

  15. ¿Cómo acercar los bienes patrimoniales a los ciudadanos? Educación Patrimonial, un campo emergente en la gestión del patrimonio cultural

    Directory of Open Access Journals (Sweden)

    Zaida García Valecillo

    2009-01-01

    Lamentablemente en las sociedades contemporáneas éste se aleja de la memoria de los ciudadanos. Por ello la gestión patrimonial busca la participación de los actores sociales, en donde la Educación Patrimonial puede ser una herramienta importante en este proceso. Esto implica desarrollar bases teóricas y metodológicas específicas que involucren a los ciudadanos en la sustentabilidad de las comunidades y sus bienes patrimoniales. En tal sentido, proponemos analizar la educación patrimonial como un campo emergente, a través de cuatro dimensiones pedagógicas que permitan sistematizar sus alcances y estrategias. Para luego articular dichas dimensiones en tres áreas de actuación educativa.

  16. Spiritualité et bien-être chez des personnes âgées : le cas des résidents dans une institution en Suisse

    OpenAIRE

    Dandarova Robert, Zhargalma; Laubscher, Karine; Brandt, Pierre-Yves

    2016-01-01

    Cet article présente les premiers résultats d’une étude exploratoire sur la spiritualité et le bien-être chez les personnes âgées résident dans un établissement médico-social de Suisse romande. De nombreuses difficultés liées à l’adaptation à un nouveau cadre de vie, la perte d’autonomie et de liberté, l’isolement et la solitude ont été rapportées par les sujets interrogés. Si pour certains résidents la religion ne représente pas d’intérêt, pour beaucoup d’autres la foi religieuse représente ...

  17. Corrélats du bien-être chez les Canadiens présentant des troubles de l’humeur ou d'anxiété

    OpenAIRE

    Orpana, H.; Vachon, J.; Pearson, C; Elliott, K.; M.; Smith; Branchard, B.

    2016-01-01

    Introduction : Notre objectif visait à étudier les variables liées au bien-être, mesurées par une autoévaluation de la santé mentale (AESM) très positive et une satisfaction élevée à l’égard de la vie (SV) chez des adultes canadiens (âgés de 18 ans et plus) présentant un trouble de l’humeur ou d'anxiété. Méthodologie : Nous avons utilisé des données nationales représentatives tirées de l’Enquête sur les personnes ayant une maladie chronique au Canada – Composante des troubles de l’humeur et d...

  18. Perspectivas del crecimiento urbano: la actividad comercial minorista y el transporte de bienes en la Zona Metropolitana de Querétaro (México

    Directory of Open Access Journals (Sweden)

    Eduardo Betanzo-Quezada

    2015-01-01

    Full Text Available Se muestran las perspectivas del crecimiento urbano, la actividad comercial minorista y su relación transversal con el transporte de bienes en la Zona Metropolitana de Querétaro (México. Con una metodología de análisis de información estadística de tipo agregado, se examinan esos determinantes con el objetivo de revelar sus tendencias en la ciudad. El paralelismo encontrado en las tendencias de comportamiento de los determinantes examinados conduce a concluir que es cada vez más necesario conectar al transporte urbano de carga con la planeación económica y urbana, y ubicarlo dentro de las prioridades de las administraciones gubernamentales.

  19. Role of the IL-12/IL-35 balance in Sjögren's syndrome.

    Science.gov (United States)

    Fogel, Olivier; Rivière, Elodie; Seror, Raphaèle; Nocturne, Gaetane; Boudaoud, Saida; Ly, Bineta; Gottenberg, Jacques-Eric; Le Guern, Véronique; Dubost, Jean-Jacques; Nititham, Joanne; Taylor, Kimberly E; Chanson, Philippe; Dieudé, Philippe; Criswell, Lindsey A; Jagla, Bernd; Thai, Alice; Mingueneau, Michael; Mariette, Xavier; Miceli-Richard, Corinne

    2017-09-12

    An interferon (IFN) signature is involved in the pathogenesis of primary Sjögren's syndrome (pSS), but whether the signature is type 1 or 2 remains controversial. Mouse models and genetic studies suggested the involvement of T helper 1 and type 2 IFN pathways. Likewise, polymorphisms of interleukin 12A gene (IL-12A), which encodes for IL-12p35, have been associated with pSS. IL-12p35 subunit is shared by 2 heterodimers, IL-12 and IL-35. To confirm the genetic association of IL-12A polymorphism and pSS and elucidate the involvement of the IL-12/IL-35 balance in pSS by functional studies. The genetic study involved 673 patients with pSS from 2 French pSS cohorts and 585 healthy French controls. Functional studies were performed on sorted monocytes, stimulated or not. IL-12A mRNA and IL-12 and IL-35 protein levels were assessed by qRT-PCR and by ELISA and a multiplex kit for IL-35 and IL-12, respectively. We confirmed the association of the IL-12A rs485497 polymorphism and pSS and found an increased serum protein level of IL-12p70 in pSS patients carrying the risk allele (p=0.016). Serum level of IL-12p70 was greater in patients than controls (p=0.0001), especially patients with more active disease (p=0.05); conversely IL-35 level was decreased in patients (p=0.0001) especially in patients with a more active disease (p=0.05). In blood cellular subsets, both IL-12p35 and EBI-3 mRNAs were detected only in B cells with a trend toward a lower level among pSS patients. Our findings emphasize the involvement of the IL-12/IL-35 balance in the pathogenesis of pSS. Serum IL-35 level was associated with low disease activity, in contrast to serum IL-12p70 level, which was rather associated with a more active disease. Copyright © 2017. Published by Elsevier Inc.

  20. Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis

    DEFF Research Database (Denmark)

    Krakauer, Martin; Sorensen, P; Khademi, M

    2008-01-01

    of the regulatory cytokine IL-10. The elevated IL-23 mRNA levels in MS patients are noteworthy in view of the newly discovered IL-23-driven Th17 T-cell subset, which is crucial in animal models of MS. Since IFN-beta therapy resulted in decreased IL-23 mRNA levels, the Th17 axis could be another target of IFN...

  1. Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members.

    Science.gov (United States)

    Dixon, Karen O; van der Kooij, Sandra W; Vignali, Dario A A; van Kooten, Cees

    2015-06-01

    IL-35 is a cytokine of the IL-12 family, existing as a heterodimer of IL-12p35 and Ebi3. IL-35 has anti-inflammatory properties and is produced by regulatory T cells in humans and mice, where it is required for optimal suppression of immune responses. Distinct from other IL-12 cytokines, the expression of IL-35 has not been described in antigen-presenting cells. In view of the immune-regulatory properties of IL-35, we investigated the expression, regulation, and function of IL-12p35 and Ebi3 in human monocyte-derived dendritic cells and tolerogenic DCs (tolDCs). These tolDCs do not produce IL-12p70 or the homodimer IL-12p40. We demonstrate that tolDCs completely lack transcriptional expression of IL-12p40. However, tolDCs maintain mRNA expression of IL-12p35 and Ebi3. Using intracellular flow cytometry and Western blot analysis, we show that tolDCs produce Ebi3 and IL-12p35, and both can be enhanced upon stimulation with IFN-γ, LPS, or CD40L. tolDCs supernatants have the capacity to suppress T-cell activation. Using IL12A silencing, we demonstrate that IL-12p35 is required for tolDCs to reach their full suppressive potential. Taken together, our results indicate that tolDCs produce IL-35, providing an additional novel mechanism by which tolDCs elicit their tolerogenic potential.

  2. IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.

    LENUS (Irish Health Repository)

    Reeves, Emer P

    2010-02-01

    Dysregulation of airway inflammation contributes to lung disease in cystic fibrosis (CF). Inflammation is mediated by inflammatory cytokines, including IL-8, which illustrates an increase in biological half-life and proinflammatory activity when bound to glycosaminoglycans (GAGs). The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF. Bronchoalveolar lavage fluid was collected from patients with CF (n = 28), non-CF controls (n = 14), and patients with chronic obstructive pulmonary disease (n = 12). Increased levels of IL-8 and reduced concentrations of IL-18 were detected in bronchial samples obtained from CF individuals. The low level of IL-18 was not a defect in IL-18 production, as the pro- and mature forms of the molecule were expressed and produced by CF epithelial cells and monocytes. There was, however, a marked competition between IL-8 and IL-18 for binding to GAGs. A pronounced loss of IL-18 binding capacity occurred in the presence of IL-8, which displaced IL-18 from these anionic-matrices, rendering the cytokine susceptible to proteolytic degradation by neutrophil elastase. As a biological consequence of IL-18 degradation, reduced levels of IL-2 were secreted by Jurkat T lymphocytes. In conclusion, a novel mechanism has been identified highlighting the potential of IL-8 to determine the fate of other inflammatory molecules, such as IL-18, within the inflammatory milieu of the CF lung.

  3. IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression.

    Directory of Open Access Journals (Sweden)

    José L Reyes

    2016-04-01

    Full Text Available Interleukin (IL-22, an immune cell-derived cytokine whose receptor expression is restricted to non-immune cells (e.g. epithelial cells, can be anti-inflammatory and pro-inflammatory. Mice infected with the tapeworm Hymenolepis diminuta are protected from dinitrobenzene sulphonic acid (DNBS-induced colitis. Here we assessed expulsion of H. diminuta, the concomitant immune response and the outcome of DNBS-induced colitis in wild-type (WT and IL-22 deficient mice (IL-22-/- ± infection. Interleukin-22-/- mice had a mildly impaired ability to expel the worm and this correlated with reduced or delayed induction of TH2 immunity as measured by splenic and mesenteric lymph node production of IL-4, IL-5 and IL-13 and intestinal Muc-2 mRNA and goblet cell hyperplasia; in contrast, IL-25 increased in the small intestine of IL-22-/- mice 8 and 12 days post-infection compared to WT mice. In vitro experiments revealed that H. diminuta directly evoked epithelial production of IL-25 that was inhibited by recombinant IL-22. Also, IL-10 and markers of regulatory T cells were increased in IL-22-/- mice that displayed less DNBS (3 mg, ir. 72h-induced colitis. Wild-type mice infected with H. diminuta were protected from colitis, as were infected IL-22-/- mice and the latter to a degree that they were almost indistinguishable from control, non-DNBS treated mice. Finally, treatment with anti-IL-25 antibodies exaggerated DNBS-induced colitis in IL-22-/- mice and blocked the anti-colitic effect of infection with H. diminuta. Thus, IL-22 is identified as an endogenous brake on helminth-elicited TH2 immunity, reducing the efficacy of expulsion of H. diminuta and limiting the effectiveness of the anti-colitic events mobilized following infection with H. diminuta in a non-permissive host.

  4. IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression.

    Science.gov (United States)

    Reyes, José L; Fernando, Maria R; Lopes, Fernando; Leung, Gabriella; Mancini, Nicole L; Matisz, Chelsea E; Wang, Arthur; McKay, Derek M

    2016-04-01

    Interleukin (IL)-22, an immune cell-derived cytokine whose receptor expression is restricted to non-immune cells (e.g. epithelial cells), can be anti-inflammatory and pro-inflammatory. Mice infected with the tapeworm Hymenolepis diminuta are protected from dinitrobenzene sulphonic acid (DNBS)-induced colitis. Here we assessed expulsion of H. diminuta, the concomitant immune response and the outcome of DNBS-induced colitis in wild-type (WT) and IL-22 deficient mice (IL-22-/-) ± infection. Interleukin-22-/- mice had a mildly impaired ability to expel the worm and this correlated with reduced or delayed induction of TH2 immunity as measured by splenic and mesenteric lymph node production of IL-4, IL-5 and IL-13 and intestinal Muc-2 mRNA and goblet cell hyperplasia; in contrast, IL-25 increased in the small intestine of IL-22-/- mice 8 and 12 days post-infection compared to WT mice. In vitro experiments revealed that H. diminuta directly evoked epithelial production of IL-25 that was inhibited by recombinant IL-22. Also, IL-10 and markers of regulatory T cells were increased in IL-22-/- mice that displayed less DNBS (3 mg, ir. 72h)-induced colitis. Wild-type mice infected with H. diminuta were protected from colitis, as were infected IL-22-/- mice and the latter to a degree that they were almost indistinguishable from control, non-DNBS treated mice. Finally, treatment with anti-IL-25 antibodies exaggerated DNBS-induced colitis in IL-22-/- mice and blocked the anti-colitic effect of infection with H. diminuta. Thus, IL-22 is identified as an endogenous brake on helminth-elicited TH2 immunity, reducing the efficacy of expulsion of H. diminuta and limiting the effectiveness of the anti-colitic events mobilized following infection with H. diminuta in a non-permissive host.

  5. The Relationship of Cytokines IL-13 and IL-17 with Autoantibodies Profile in Early Rheumatoid Arthritis

    Directory of Open Access Journals (Sweden)

    Isabela Siloşi

    2016-01-01

    Full Text Available Aims. In the present study, we aimed to assess the concentrations of IL-13 and IL-17 in serum of patients with early rheumatoid arthritis (eRA, the investigation of correlation between the concentrations of these cytokines and disease activity score, and the concentration of some autoantibodies and the evaluation of the utility of IL-13 and -17 concentration measurements as markers of disease activity. Materials and Methods. Serum samples were collected from 30 patients and from 28 controls and analysed parameters. Results. The serum concentrations of IL-13, IL-17, anti-CCP, and IgM-RF were statistically significantly higher in patients with eRA, compared to the controls. IL-13 concentrations in the severe and moderate groups with eRA were statistically higher than in the mild and control groups. Also, in the case of IL-17, serum concentrations increased proportionally with the disease activity of eRA. We observe that concentrations of IL-13 and -17 did not correlate with autoantibodies. IL-17 concentration significantly positively correlated with CRP, while IL-13 concentration significantly negatively correlated with CRP. Disease activity score, DAS28, was strongly positively correlated with levels of ESR and weakly positively correlated with concentrations of anti-RA33 autoantibodies. IL-13 has a higher diagnostic utility than IL-17, CRP, ESR, IgM-RF, and anti-CCP as markers of disease activity. Conclusions. The presence of higher IL-13 and IL-17 serum levels in patients, compared with those of controls, confirms that these markers, found with high specificity, might be involved in the pathogenesis of eRA. IL-13 and IL-17 might be of better usefulness in the prediction of eRA activity status than IgM-RF and anti-CCP.

  6. IL-25的研究进展

    Institute of Scientific and Technical Information of China (English)

    张永梅; 徐青

    2008-01-01

    IL-25是IL-17家族中发现的新成员之-,IL-17家族是由新近发现的-组与IL-17具有29%~50%的同源性,由155~197个氨基酸组成的相对分子质量(Mt)大小在20000~30000之间的细胞因子组成。目前认为IL-17家族中至少有6个成员,它们分别是IL-17A、IL-17B、IL-17C、IL-17D、IL-17E、IL-17F。IL-17/IL-17A是IL-17家族中的主要成员,

  7. The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy

    DEFF Research Database (Denmark)

    Kragstrup, Tue Wenzel; Otkjaer, Kristian; Holm, Christian

    2008-01-01

    chemoattractant protein 1 (CCL2/MCP-1) secretion, but not tumour necrosis factor alpha mRNA synthesis or IL-6 secretion. Both IL-20 and IL-24 showed correlations to CCL2/MCP-1 in plasma from rheumatoid arthritis and spondyloarthropathy patients. This study associates IL-20 and IL-24 to the synovium of rheumatoid...... whereas IL-24 protein was observed in endothelial cells and mononuclear cells. IL-20 receptor type 1 and IL-22 receptor were expressed by granulocytes in the synovial fluid. In synovial fluid mononuclear cell cultures, stimulation with recombinant human IL-20 or recombinant human IL-24 induced monocyte...

  8. Clinical associations of IL-10 and IL-37 in systemic lupus erythematosus

    Science.gov (United States)

    Godsell, Jack; Rudloff, Ina; Kandane-Rathnayake, Rangi; Hoi, Alberta; Nold, Marcel F.; Morand, Eric F.; Harris, James

    2016-01-01

    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the development of autoantibodies to nuclear antigens and inflammatory responses mediated by multiple cytokines. Although previous studies have determined clinical associations between SLE and the anti-inflammatory cytokines IL-10 and IL-37, their role in the disease, or their potential as biomarkers, remains unclear. We examined serum levels of IL-10 and IL-37 in a large cohort of SLE patients, with detailed longitudinal clinical data. We demonstrate a statistically significant association of serum IL-10 with disease activity, with higher levels in active compared to inactive disease. High first visit IL-10 was predictive of high subsequent disease activity; patients with IL-10 in highest quartile at first visit were 3.6 times more likely to have active disease in subsequent visits. Serum IL-37 was also higher in SLE patients compared to control, and was strongly associated with Asian ethnicity. However, IL-37 was not statistically significantly associated with disease activity. IL-37 was significantly reduced in patients with organ damage but this association was attenuated in multivariable analysis. The data suggest that IL-10, but not IL-37, may have potential as a biomarker predictive for disease activity in SLE. PMID:27708376

  9. IL-31 and IL-33 circulating levels in allergic contact dermatitis.

    Science.gov (United States)

    Guarneri, F; Minciullo, P L; Mannucci, C; Calapai, F; Saitta, S; Cannavò, S P; Gangemi, S

    2015-09-01

    Enhanced IL-31 expression in skin biopsies is present in allergic contact dermatitis (ACD). IL-33 expression is induced in keratinocytes and in skin of ACD patients. This overexpression is present in both allergic and irritant conditions. The aim of this work was to test the systemic involvement of IL-31 and IL-33 in ACD. IL-31 levels were significantly higher in patients than in controls. IL-33 serum levels, on the contrary, were similar in patients and controls. This work shows a possible systemic involvement of IL-31 and the absence of a systemic involvement of IL-33 in ACD. IL-31 levels do not seem related to the allergen involved, and did not change on the strength of the allergen involved. More likely, IL-31 levels are related to the itch. IL-33, instead, is secreted from damaged or inflamed tissue and might function as an early warning system at the site of skin damage. In the future, IL-31 could be a possible therapeutic target of all pruritic skin diseases resistant to conventional therapies.

  10. Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators.

    Science.gov (United States)

    Tedder, Thomas F; Leonard, Warren J

    2014-08-01

    IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that modulate immune responses and limit diverse autoimmune diseases. A new study demonstrates that IL-35 has a similar function. Identifying regulatory circuits that control B10-cell function in vivo might open the door to future treatments for autoimmune diseases.

  11. Clinical Significance of IL-23 Regulating IL-17A and/or IL-17F Positive Th17 Cells in Chronic Periodontitis

    Directory of Open Access Journals (Sweden)

    Zhenhua Luo

    2014-01-01

    Full Text Available Objective. To investigate the expression level and clinical significance of (IL-17A+ and/or IL-17F+ Th17 cells under IL-23 regulation in patients of chronic periodontitis (CP and healthy controls (HC. Materials and Methods. The whole peripheral blood samples were collected from 30 CP patients and 25 healthy controls. Flow cytometry was used to test the (IL-17A+ and/or IL-17F+ Th17 expression level. Recombinant human IL-23 (rhIL-23 was used to detect Th17 differentiation and expansion. Correlation coefficient analysis between Th17 expression level and clinical parameters was analyzed by SPSS software. Results. Flow cytometry results showed that IL-17A+IL-17F− and IL-17A−IL-17F+ Th17 were both increased in CP group than in HC group (P < 0.01, while, under recombinant human IL-23 (rhIL-23 stimulation, the number of IL-17A+IL-17F− Th17 cells was significantly increased in both CP and HC groups (P < 0.01. Interestingly, IL-17A−IL-17F+ Th17 cells were only increased in CP group after rhIL-23 stimulation. Additionally, correlation coefficient analysis showed significant correlation between IL-17A+IL-17F− Th17 cell and attachment loss or probing depth (P < 0.05. Conclusions. This study indicates that both the IL-17A+IL-17F− and IL-17A−IL-17F+ Th17 cells may be involved in pathogenesis of periodontitis. The role of these Th17 cells in the disease pathogenesis needs to be further investigated.

  12. Knocking out IL-6 by vaccination

    DEFF Research Database (Denmark)

    Galle, Pia; Hougs, Lotte; Barington, Torben

    2004-01-01

    Inappropriate expression of IL-6 plays a role in various inflammatory conditions, degenerative diseases, and cancers. Several model systems have been developed that can specifically block IL-6-receptor interactions. Here we present a simple and highly effective approach based on vaccination...

  13. IL-6 Compared to Young Mice

    Directory of Open Access Journals (Sweden)

    Jihyun Park

    2014-01-01

    Full Text Available Inflamm-aging indicates the chronic inflammatory state resulting from increased secretion of proinflammatory cytokines and mediators such as IL-6 in the elderly. Our principle objective was to identify cell types that were affected with aging concerning IL-6 secretion in the murine model. We compared IL-6 production in spleen cells from both young and aged mice and isolated several types of cells from spleen and investigated IL-6 mRNA expression and protein production. IL-6 protein productions in cultured stromal cells from aged mice spleen were significantly high compared to young mice upon LPS stimulation. IL-6 mRNA expression level of freshly isolated stromal cells from aged mice was high compared to young mice. Furthermore, stromal cells of aged mice highly expressed IL-6 mRNA after LPS injection in vivo. These results suggest that stromal cells play a role in producing IL-6 in aged mice and imply that they contribute to the chronic inflammatory condition in the elderly.

  14. Blood Serum Levels of IL-2, IL-6, IL-8, TNF-α and IL-1β in Patients on Maintenance Hemodialysis

    Institute of Scientific and Technical Information of China (English)

    Jacek Rysz; Maciej Banach; Aleksandra Cialkowska-Rysz; Robert Stolarek; Marcin Barylski; Jaroslaw Drozdz; Piotr Okonski

    2006-01-01

    Cytokines are essential mediators of immune response and inflammatory reactions. Patients with chronic renal failure (CRF) commonly present with abnormalities of immune function related with impaired kidney function and the accumulation of uremic toxins in addition to bioincompatibility of dialyzer membranes. During a hemodialysis (HD) session, cytokines are released mainly by monocytes activated by endotoxin-type compounds in dialyzer fluid,complement factors and direct contact with dialyzer membrane. The study included 15 CRF patients, aged 36.4 ± 2.9 years, on regular HD maintenance therapy for mean 68 ± 10 months and 15 healthy controls. It was designed to assess serum levels of a panel of inflammatory cytokines: IL-1β, IL-2, IL-6, IL-8 and TNF-α in CRF patients on regular maintenance HD before, 20, 60 and 240 minutes of a single HD session in parallel with C-reactive protein (CRP) as an additional parameter. CRP concentration was increased in HD patients when compared with healthy controls. The concentrations of IL-1, IL-6, IL-8 and TNF-α were increased, whereas the serum level of IL-2 was not altered during a single HD session.

  15. IL-6 and mouse oocyte spindle.

    Directory of Open Access Journals (Sweden)

    Jashoman Banerjee

    Full Text Available Interleukin 6 (IL-6 is considered a major indicator of the acute-phase inflammatory response. Endometriosis and pelvic inflammation, diseases that manifest elevated levels of IL-6, are commonly associated with higher infertility. However, the mechanistic link between elevated levels of IL-6 and poor oocyte quality is still unclear. In this work, we explored the direct role of this cytokine as a possible mediator for impaired oocyte spindle and chromosomal structure, which is a critical hurdle in the management of infertility. Metaphase-II mouse oocytes were exposed to recombinant mouse IL-6 (50, 100 and 200 ng/mL for 30 minutes and subjected to indirect immunofluorescent staining to identify alterations in the microtubule and chromosomal alignment compared to untreated controls. The deterioration in microtubule and chromosomal alignment were evaluated utilizing both fluorescence and confocal microscopy, and were quantitated with a previously reported scoring system. Our results showed that IL-6 caused a dose-dependent deterioration in microtubule and chromosomal alignment in the treated oocytes as compared to the untreated group. Indeed, IL-6 at a concentration as low as 50 ng/mL caused deterioration in the spindle structure in 60% of the oocytes, which increased significantly (P<0.0001 as IL-6 concentration was increased. In conclusion, elevated levels of IL-6 associated with endometriosis and pelvic inflammation may reduce the fertilizing capacity of human oocyte through a mechanism that involves impairment of the microtubule and chromosomal structure.

  16. Autocrine IL-6 mediates pituitary tumor senescence

    Science.gov (United States)

    Fuertes, Mariana; Ajler, Pablo; Carrizo, Guillermo; Cervio, Andrés; Sevlever, Gustavo; Stalla, Günter K.; Arzt, Eduardo

    2017-01-01

    Cellular senescence is a stable proliferative arrest state. Pituitary adenomas are frequent and mostly benign, but the mechanism for this remains unknown. IL-6 is involved in pituitary tumor progression and is produced by the tumoral cells. In a cell autonomous fashion, IL-6 participates in oncogene-induced senescence in transduced human melanocytes. Here we prove that autocrine IL-6 participates in pituitary tumor senescence. Endogenous IL-6 inhibition in somatotroph MtT/S shRNA stable clones results in decreased SA-β-gal activity and p16INK4a but increased pRb, proliferation and invasion. Nude mice injected with IL-6 silenced clones develop tumors contrary to MtT/S wild type that do not, demonstrating that clones that escape senescence are capable of becoming tumorigenic. When endogenous IL-6 is silenced, cell cultures derived from positive SA-β-gal human tumor samples decrease the expression of the senescence marker. Our results establish that IL-6 contributes to maintain senescence by its autocrine action, providing a natural model of IL-6 mediated benign adenoma senescence. PMID:27902467

  17. IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells

    Science.gov (United States)

    Guenova, Emmanuella; Skabytska, Yuliya; Hoetzenecker, Wolfram; Weindl, Günther; Sauer, Karin; Tham, Manuela; Kim, Kyu-Won; Park, Ji-Hyeon; Seo, Ji Hae; Ignatova, Desislava; Cozzio, Antonio; Levesque, Mitchell P.; Volz, Thomas; Köberle, Martin; Kaesler, Susanne; Thomas, Peter; Mailhammer, Reinhard; Ghoreschi, Kamran; Schäkel, Knut; Amarov, Boyko; Eichner, Martin; Schaller, Martin; Clark, Rachael A.; Röcken, Martin; Biedermann, Tilo

    2015-01-01

    Interleukin 4 (IL-4) can suppress delayed-type hypersensitivity reactions (DTHRs), including organ-specific autoimmune diseases in mice and humans. Despite the broadly documented antiinflammatory effect of IL-4, the underlying mode of action remains incompletely understood, as IL-4 also promotes IL-12 production by dendritic cells (DCs) and IFN-γ–producing TH1 cells in vivo. Studying the impact of IL-4 on the polarization of human and mouse DCs, we found that IL-4 exerts opposing effects on the production of either IL-12 or IL-23. While promoting IL-12–producing capacity of DCs, IL-4 completely abrogates IL-23. Bone marrow chimeras proved that IL-4–mediated suppression of DTHRs relies on the signal transducer and activator of transcription 6 (STAT6)-dependent abrogation of IL-23 in antigen-presenting cells. Moreover, IL-4 therapy attenuated DTHRs by STAT6- and activating transcription factor 3 (ATF3)-dependent suppression of the IL-23/TH17 responses despite simultaneous enhancement of IL-12/TH1 responses. As IL-4 therapy also improves psoriasis in humans and suppresses IL-23/TH17 responses without blocking IL-12/TH1, selective IL-4–mediated IL-23/TH17 silencing is promising as treatment against harmful inflammation, while sparing the IL-12–dependent TH1 responses. PMID:25646481

  18. IL-25 and inflammatory autoimmune diseases%IL-25与自身免疫炎症性疾病

    Institute of Scientific and Technical Information of China (English)

    唐宏勇; 李忆农

    2013-01-01

    IL-25 is a newly discovered member of IL-1 7 family,with immunomodulatory functions.IL-25 may participate in type 2 immune response,to promote IL-4,IL-5,IL-9,IL-1 3 and other cytokines se-cretion. It also binds with IL-1 7A and IL-1 7RA receptor,inhibits joint cartilage formation. By stimulating the release of nitric oxide and proinflammatory cytokines IL-6,IL-8 production,it can participate in autoimmune inflammatory diseases.%IL-25是新近发现的IL-17家族成员,具有免疫调节功能。IL-25可参与2型免疫反应,促进IL-4、IL-5、IL-9、IL-13等细胞因子分泌,也可与IL-17A及其受体IL-17RA结合,亦能抑制关节软骨的形成,刺激一氧化氮的释放以及前炎症因子IL-6、IL-8的产生,进而参与自身免疫炎症疾病。

  19. DETERMINATION OF URINE TUMOR NECROSIS FACTOR, IL-6, IL-8 AND SERUM IL-6 IN PATIENTS WITH HEMORRHAGIC FEVERS WITH RENAL SYNDROME

    Institute of Scientific and Technical Information of China (English)

    Fan Wanhu; Chen Ruilin; Yue Jinsheng; Liu Zhengwen; Zhang Shulin

    2006-01-01

    Objective To explore the roles of cytokines in the pathogenesis of hemorrhagic fever with renal syndrome(HFRS). Methods Double-antibody sandwich ELISA was used to determine serum interleukin (IL)-6, urine tumor necrosis factor (TNF), IL-6 and IL-8 levels in 56 patients with HFRS. Results Serum IL-6, urine TNF, IL-6 and IL-8 concentrations in HFRS patients were significantly higher than those in control group, respectively (P<0.001). The concentrations increased at fever stage, then continued to increase during hypotension stage and peaked at oliguria stage. The concentrations of serum IL-6, urine TNF, IL-6 and IL-8 increased in accord with the severity of the disease and differed greatly among different types of the disease. Serum IL-6 had remarkable relationships with serum specific antibodies. It was positively related to serum β2-microglobulin (β2-MG), blood ureanitrogen (BUN) and creatinine (Cr). Significant positive relationships were also found both between urine IL-6 and TNF, and between IL-6 and IL-8 (r=0.5768, P<0.05; r=0.3760, P<0.01). Conclusion TNF, IL-6 and IL-8 activated during the course of the disease. IL-6 is associated with the immunopathological lesions caused by the hyperfunction of humoral immune response. IL-6, IL-8 and TNF are involved in the renal immune impairment. Determining them might, in certain extent, be used in predicting the prognosis and outcome of patients with HFRS.

  20. IL5 — EDRN Public Portal

    Science.gov (United States)

    From NCBI Gene: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013

  1. Il punto su Sebastijan Krelj

    Directory of Open Access Journals (Sweden)

    Neva Godini

    1987-12-01

    Full Text Available Come Sebastianus  Krelo Austriacus si era iscritto all'Accademia  di Jena nel 1557 colui che oggi viene considerato uno dei protagonisti di spicco dell'epopea pro­ testante slovena. Sono ormai parecchi anni che, nel celebrare l'anniversario del1584 nella cultura e storia slovena (anno della pubblicazione della traduzione della Bibbia ad opera di Jurij Dalmatin e della prima grammatica slovena, scritta in Iatino, Arti­ cae horulae di Adam Bohorič, non si contano ormai più libri, saggi, articoli, con­ vegni e commemorazioni varie così in Slovenia come all'estero  ed in particolare a Derendingen, oggi periferia della città di Tübingen, che diventò Ia seconda patria di colui che viene considerato il padre della letteratura slovena, cioè Primož Trubar.  E nella vicina città di Urach aveva sede l'importantissima tipografia dei protestanti sloveni e non: basterà ricordare che qui in soli cinque anni vennero alia stampa ben 50 tra pubblicazioni in sloveno, croato, glagolitico, italiano ecc. Ma queste dovreb­ bero essere cose abbastanza  risapute. Meno conosciuta e, oseremmo dire quasi un po' trascurata   in questa messe di commemorazioni, appare l'opera  e l'importanza di uno dei protagonisti del protestantesimo sloveno, appunto  Sebastijan Krelj.

  2. Regulation of inflammatory responses by IL-17F

    Science.gov (United States)

    Yang, Xuexian O.; Chang, Seon Hee; Park, Heon; Nurieva, Roza; Shah, Bhavin; Acero, Luis; Wang, Yi-Hong; Schluns, Kimberly S.; Broaddus, Russell R.; Zhu, Zhou; Dong, Chen

    2008-01-01

    Although interleukin (IL) 17 has been extensively characterized, the function of IL-17F, which has an expression pattern regulated similarly to IL-17, is poorly understood. We show that like IL-17, IL-17F regulates proinflammatory gene expression in vitro, and this requires IL-17 receptor A, tumor necrosis factor receptor–associated factor 6, and Act1. In vivo, overexpression of IL-17F in lung epithelium led to infiltration of lymphocytes and macrophages and mucus hyperplasia, similar to observations made in IL-17 transgenic mice. To further understand the function of IL-17F, we generated and analyzed mice deficient in IL-17F or IL-17. IL-17, but not IL-17F, was required for the initiation of experimental autoimmune encephalomyelitis. Mice deficient in IL-17F, but not IL-17, had defective airway neutrophilia in response to allergen challenge. Moreover, in an asthma model, although IL-17 deficiency reduced T helper type 2 responses, IL-17F–deficient mice displayed enhanced type 2 cytokine production and eosinophil function. In addition, IL-17F deficiency resulted in reduced colitis caused by dextran sulfate sodium, whereas IL-17 knockout mice developed more severe disease. Our results thus demonstrate that IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases. PMID:18411338

  3. Se démarquer dans l’industrie du bien-être. Transnationalisme, innovation et indianité Standing out in the wellness industry. Transnationalism, innovation and indianness

    Directory of Open Access Journals (Sweden)

    Laurent Pordié

    2011-11-01

    Full Text Available L’industrie du bien-être se caractérise à la fois par un fort potentiel d’innovation dans le domaine thérapeutique et par une prétention à l’ancienneté de ces nouvelles thérapies. Cet article propose d’analyser ce paradoxe en étudiant les logiques à l’œuvre dans la construction d’une marque identifiant et distinguant Mango Spa, une chaîne indienne de centres de soins et de remise en forme. Il s’intéresse aux sens et aux implications de l’innovation thérapeutique dans le cas d’une firme qui revendique l’authenticité de ses traitements tout en puisant dans des ressources d’influences multiples afin de s’adapter à une clientèle cosmopolite. Ces services et ces produits fondent leur légitimité sur la tradition ayurvédique, mais ils doivent toutefois la défier afin d’acquérir leur propre visibilité. C’est ainsi que Mango Spa se démarque de ses concurrents. De nouvelles thérapies « indiennes » sont créées en mobilisant clients internationaux, thérapeutes de cultures disparates et industriels établis hors de l’Inde. La marque est produite au travers d’un faisceau complexe de relations transnationales. En examinant les forces globales et le caractère multidimensionnel de la production d’une marque indienne, cet article renseigne plus généralement sur la circulation et la transformation des idées, des objets et des pratiques.The wellness industry is characterized by both a high innovation potential in the therapeutic field and a claim to the antiquity of these new therapies. This article aims to analyze this paradox by studying the logic at work in the construction of a brand identifying and distinguishing Mango Spa, an Indian chain of health and fitness centers. Particularly interesting are the meanings and implications of therapeutic innovation in the case of a firm claiming the authenticity of its treatments while drawing on multiples resources and influences to adapt them to a

  4. Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology.

    Science.gov (United States)

    Grotenboer, Néomi S; Ketelaar, Maria E; Koppelman, Gerard H; Nawijn, Martijn C

    2013-03-01

    Asthma is a complex disease that results from the interaction between genetic predisposition and environmental factors. Recently, genome-wide association studies have identified a number of genes that significantly contribute to asthma. Two of these genes, IL33 and IL-1 receptor-like 1 (IL1RL1), act in one signal transduction pathway. IL33 encodes a cytokine released on damage of cells, whereas IL1RL1 encodes part of the IL-33 receptor complex. Recent progress made in functional studies in human subjects and mouse models of allergic airway disease indicate a central role of IL-33 signaling in driving TH2 inflammation, which is central to eosinophilic allergic asthma. Here, IL-33 acts on cells of both the adaptive and innate immune systems. Very recently, a novel population of IL-33-responsive innate immune cells, the type 2 innate lymphoid cells, was found to produce hallmark TH2 cytokines, such as IL-5 and IL-13. The relevance of these cells for asthma is underscored by the identification of retinoic acid-related orphan receptor α(RORA), the gene encoding the transcription factor critical for their differentiation, as another asthma gene in genome-wide association studies. This review describes the mechanisms through which genetic variation at the IL33 and IL1RL1 loci translates into increased susceptibility for asthma. We propose that genetic variation associated with asthma at the IL33 and IL1RL1 loci can be dissected into independent signals with distinct functional consequences for this pathway that is central to asthma pathogenesis. Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

  5. 支气管哮喘患者IL-12/IL-13失衡的研究%Immalance of IL-12/IL-13 asthmatic patients

    Institute of Scientific and Technical Information of China (English)

    毛继芳; 刘伟; 律洁; 孙永峰

    2004-01-01

    目的了解支气管哮喘患者外周血白细胞介素12(IL-12)、白细胞介素13(IL-13)是否失衡.方法选取急性发作期哮喘患者(哮喘组25例),健康志愿者(对照组)15例.分别对哮喘组、对照组留取血标本,采取双抗体夹心酶联免疫吸附法(ELISA)检测上述两组血清中IL-12、IL-13水平,并对测定结果进行统计学处理.结果哮喘组IL-12水平为(58.50±14.25)mg/L,较对照组(85.52±13.14)ng/L明显降低,差异有显著性(P<0.01);哮喘组IL-13水平为(131.27±28.45)ng/L较对照组(92.30±14.43)ng/L明显增高,差异有显著性(P<0.01).结论哮喘患者体内IL-13过度产生,IL-12则产生不足,使IL-12/IL-13失衡.

  6. Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation

    DEFF Research Database (Denmark)

    Galle, Pia; Jensen, Lene; Andersson, Christina

    2007-01-01

    ; yet they appear healthy and do not exhibit overt clinical or laboratory abnormalities. We induced comparable levels of aAb-IL-6 in different mouse strains by vaccination with immunogenic IL-6 analogues. We observed that the induced aAb-IL-6 protected against collagen-induced arthritis and experimental...... allergic encephalitis. Furthermore, aAb-IL-6 carrying mice displayed increased plasma TNFalpha concentrations upon challenge with LPS. Taken together, induction of IL-6 autoantibodies was possible in different mouse strains. The autoantibodies influenced experimental inflammation. This immunotherapeutic...

  7. Effect of glycyrrhizin on chronic urticaria patients in IL-4,IL-8,IL-17 and IL-22%18-β甘草酸苷对慢性荨麻疹患者血清中IL-4、IL-8、IL-17和IL-22的影响

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    目的:通过对18-β甘草酸苷治疗前后慢性荨麻疹患者血清中IL-4、IL-8、IL-17和IL-22的检测,探讨甘草酸苷治疗慢性荨麻疹的作用机制。方法:用Western blot检测法分别检测20例慢性荨麻疹患者经甘草酸苷治疗前、后及20例健康对照组血清中IL-4、IL-8、IL-17和IL-22的水平。结果:慢性荨麻疹患者经18-β甘草酸苷治疗前血清中IL-4浓度(22.75±6.87pg/ml)、IL-8浓度(20.26±4.52pg/ml)、IL-17浓度(24.62±7.28pg/ml)和IL-22浓度(23.26±9.04pg/ml)高于健康对照组(P<0.05)。治疗后,IL-4浓度(14.44±4.29pg/ml)、IL-8浓度(12.24±3.32pg/ml)、IL-17浓度(13.32±1.61pg/ml)和IL-22浓度(14.32±1.59pg/ml)较治疗前显著降低(P<0.05),与健康对照比较差异无统计学意义(P>0.05)。结论:慢性荨麻疹患者的血清中存在IL-4、IL-8、IL-17和IL-22水平异于正常,提示慢性荨麻疹患者的机体免疫功能紊乱;而18-β甘草酸苷治疗后血清中IL-4、IL-8、IL-17和IL-22明显降低,提示18-β甘草酸苷可能通过影响辅助T细胞相关因子来发挥治疗慢性荨麻疹的作用。%Objective Based on measurement of chronic urticaria patients serum IL-4 and IL-8,IL-17 and IL-22 before and after 18 beta glycyrrhizin in the treatment of glycyrrhizin mechanism on treating chronic urticaria. Methods The levels of serum IL-22,IL-8,IL-17 and IL-4 in 20 cases of chronic urticaria were detected by blot Western assay and 20 cases of healthy controls. Results In patients with chronic urticaria by 18 beta glycyrrhizin treatment IL and serum concentrations of IL- 4(22.75 ± 6.87pg/ml),IL- 8 concentration(20.26 ± 4.52pg/ml),IL- 17 concentration(24.62 ± 7.28pg/ml)and IL- 22 concentration (23.26±9.04pg/ml),higher than the healthy control group(P0.05). Conclusion The serum of patients with chronic urticaria of IL-4 and IL-8,IL-17 and IL-22 levels different from normal,suggesting that chronic urticaria patients with the

  8. Entre le « bien » et les exigences techniques de la loi. Le cas du prix de transfert

    OpenAIRE

    Vidal, Jean-Pierre

    2015-01-01

    Certains contribuables croient que les fiscalistes peuvent se conformer à la loi sans nécessairement se conformer à l’éthique. Cette opinion remet en cause leur confiance dans le système fiscal et ceux qui sont coupables d’évasion fiscale croient qu’ils ne sont pas les seuls et pas les pires. Dans le domaine du prix de transfert, il existe pourtant de bonnes raisons de croire qu’une entreprise multinationale ne peut pas échapper à ses obligations fiscales légitimes en choisissant de suivre...

  9. Définition d'un panier de biens et services : pour la mesure de l'accessibilité des personnes défavorisées aux services

    OpenAIRE

    Caubel, David; Quéré, Gilles

    2007-01-01

    Rapport d'étude du CERTU; L'objectif de cette étude est de proposer une méthode de construction d'un panier de biens et services de proximité. Ce panier de biens sera utilisé pour analyser les disparités d'accès aux équipements de proximité dans les aires urbaines, selon le quartier dans lequel on habite, et selon la catégorie sociale à laquelle on appartient. Cette analyse sera diffusée dans un autre rapport d'études.Le panier de biens est constitué d'enregistrements du fichier Sirene de l'I...

  10. The effect of valtrex on T cell subset and IL2, IL6 and IL10 level in patients with herpes zoster

    Institute of Scientific and Technical Information of China (English)

    Gui-E Wang; Jian Chen; Ling Chen

    2015-01-01

    Objective:To explore the effects of valtrex on T cell subset and IL2, IL6 and IL10 level in patients with herpes zoster.Methods: 120 patients with herpes zoster in our hospital were analyzed. The serum T cell subset and IL2, IL6 and IL10 were detected by Western Blotting. Healthy volunteers were enrolled as control group.Results: The CD4+ level was increased significantly while the CD8+ decreased significantly, and the ratio of the two increased too (P all<0.01). The IL6 and IL10 levels were increased significantly (P<0.01). But no significant change in IL2 level was observed.Conclusion:Valtrex is effective on herpes zoster by regulating T cell subset, IL6 and IL10 levels.

  11. IL-12/IL-23抑制剂治疗银屑病

    Institute of Scientific and Technical Information of China (English)

    林熙然; 黄畋

    2009-01-01

    IL-12细胞因子家族包括IL-12、IL-23、IL-27和IL-35,为异二聚体细胞因子,由一条α链和一条β链组成。研究表明,树突细胞(DC)产生IL-12和IL-23的功能对CD4+T细胞反应的结果有重要影响。因此,IL-12/IL-23已成为治疗CD4+T细胞介导的自身免疫炎症性疾病的新靶点,开发的IL-12/IL-23抑制剂有ustekinumab(CNTO-1275)和ABT-874以及小分子药物阿吡莫德(apilimod,STA-5326)等,前两种者已用于治疗银屑病。

  12. Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients

    Directory of Open Access Journals (Sweden)

    Xiaoqing Zhang

    2017-01-01

    Full Text Available Aims. The influence of interleukin-10 (IL-10 and interleukin-18 (IL-18 polymorphisms on tacrolimus pharmacokinetics had been described in liver and kidney transplantation. The expression of cytokines varied in different kinds of transplantation. The influence of IL-10 and IL-18 genetic polymorphisms on the pharmacokinetic parameters of tacrolimus remains unclear in lung transplantation. Methods. 51 lung transplant patients at Shanghai Pulmonary Hospital were included. IL-18 polymorphisms (rs5744247 and rs1946518, IL-10 polymorphisms (rs1800896, rs1800872, and rs3021097, and CYP3A5 rs776746 were genotyped. Dose-adjusted trough blood concentrations (C/D ratio, mg/kg body weight in lung transplant patients during the first 4 postoperative weeks were calculated. Results. IL-18 rs5744247 allele C and rs1946518 allele A were associated with fast tacrolimus metabolism. Combined analysis showed that the numbers of low IL-18 mRNA expression alleles had positive correlation with tacrolimus C/D ratios in lung transplant recipients. The influence of IL-18 polymorphisms on tacrolimus C/D ratios was observed in CYP3A5 expresser recipients, but not in CYP3A5 nonexpresser recipients. No clinical significance of tacrolimus C/D ratios difference of IL-10 polymorphisms was found in our data. Conclusions. IL-18 polymorphisms may influence tacrolimus elimination in lung transplantation patients.

  13. Serum Levels of IL-10 and IL-22 Cytokines in Patients with Psoriasis.

    Science.gov (United States)

    Sobhan, Mohammad Reza; Farshchian, Mahmood; Hoseinzadeh, Ali; Ghasemibasir, Hamid Reza; Solgi, Ghasem

    2016-12-01

    As a chronic inflammatory condition, psoriasis results from an interaction between genetic and immunologic factors in a predisposing environment. In spite of compelling evidence for the role of T cells and cytokines in psoriasis, interleukin (IL)-10 and IL-22 have not been sufficiently investigated. To assess the serum levels of IL-10 and IL-22 in patients with psoriasis compared to healthy controls. A total of 28 patients with psoriasis were compared with 28 age and sex-matched healthy subjects. Psoriasis Area and Severity Index (PASI) criteria were used to measure the severity of the disease. Serum levels of IL-10 and IL-22 were measured in both groups and compared. The mean serum level of IL-10 was 89.5±18.7 in patients compared to 117.2±23.4 pg/ml in the controls (p=0.36). Also, serum level of IL-22 was 284.1±49.7 in patients versus 425.4±82.8 pg/ml in control group (p=0.17). There was a significant direct correlation between levels of IL-10 and IL-22 in patients group (p=0.0005). The clinical severity of psoriasis was significantly correlated with high levels of IL-22 (ppsoriasis.

  14. Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.

    Science.gov (United States)

    Mazzucchelli, Renata; Hixon, Julie A; Spolski, Rosanne; Chen, Xin; Li, Wen Qing; Hall, Veronica L; Willette-Brown, Jami; Hurwitz, Arthur A; Leonard, Warren J; Durum, Scott K

    2008-10-15

    Interleukin-7 (IL-7), a cytokine produced by stromal cells, is required for thymic development and peripheral homeostasis of most major subsets of T cells. We examined whether regulatory T (Treg) cells also required the IL-7 pathway by analyzing IL-7Ralpha(-/-) mice. We observed a striking reduction in cells with the Treg surface phenotype (CD4, CD25, GITR (glucocorticoid-induced tumor necrosis factor [TNF]-like receptor), CD45RB, CD62L, CD103) or intracellular markers (cytotoxic T-lymphocyte-associated antigen-4, CTLA-4, and forkhead box transcription factor 3, Foxp3). Foxp3 transcripts were virtually absent in IL-7Ralpha(-/-) lymphoid tissues, and no Treg cell suppressive activity could be detected. There are 2 known ligands for IL-7Ralpha: IL-7 itself and thymic stromal lymphopoietin (TSLP). Surprisingly, mice deficient in IL-7 or the other chain of the TSLP receptor (TSLPR) developed relatively normal numbers of Treg cells. Combined deletion of IL-7 and TSLP receptor greatly reduced Treg cell development in the thymus but was not required for survival of mature peripheral Treg cells. We conclude that Treg cells, like other T cells, require signals from the IL-7 receptor, but unlike other T cells, do not require IL-7 itself because of at least partially overlapping actions of IL-7 and TSLP for development of Treg cells.

  15. The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes.

    Science.gov (United States)

    Nace, Judith; Fortunato, Stephen J; Maul, Holger; Menon, Ramkumar

    2010-11-01

    interleukin (IL)-24 and -29 are novel cytokines, produced by immune cells in response to microbial antigens. The functions of these cytokines in the reproductive system are unknown. We examined the expression pattern of IL-24 and IL-29 in human fetal membranes from preterm and term births and in in vitro in response to microbial antigens. fetal membranes collected from cesarean sections at term (normal, not in labor) were placed in culture for 48 h. These membranes were then stimulated with bacterial lipopolysaccharide (LPS) or viral antigen poly-inosinic and cytidylic acid (polyIC) for an additional 24 h. Amniotic fluids (AF) and fetal membranes were also collected from preterm and term deliveries. IL-24 and IL-29 expressions were studied by RT-PCR. ELISA documented culture media and AF cytokine concentrations. IL-24 and IL-29 expressions were seen in cultured fetal membranes regardless of stimulation. Expressions were also found in preterm and term labor membranes, but not in non-labor tissues at term. IL-24 concentrations were higher after LPS stimulation whereas IL-29 concentrations were higher after polyIC-stimulation. AF analysis did not detect either of the cytokines either preterm or term. this is the first study to report IL-24 and IL-29 expressions in human fetal membranes. Higher concentrations of these cytokines in response to distinct infectious stimuli suggest different pathways for fetal immune response during infection.

  16. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies.

    Science.gov (United States)

    Brydges, Susannah D; Broderick, Lori; McGeough, Matthew D; Pena, Carla A; Mueller, James L; Hoffman, Hal M

    2013-11-01

    The inflammasome is a cytoplasmic multiprotein complex that promotes proinflammatory cytokine maturation in response to host- and pathogen-derived signals. Missense mutations in cryopyrin (NLRP3) result in a hyperactive inflammasome that drives overproduction of the proinflammatory cytokines IL-1β and IL-18, leading to the cryopyrin-associated periodic syndromes (CAPS) disease spectrum. Mouse lines harboring CAPS-associated mutations in Nlrp3 have elevated levels of IL-1β and IL-18 and closely mimic human disease. To examine the role of inflammasome-driven IL-18 in murine CAPS, we bred Nlrp3 mutations onto an Il18r-null background. Deletion of Il18r resulted in partial phenotypic rescue that abolished skin and visceral disease in young mice and normalized serum cytokines to a greater extent than breeding to Il1r-null mice. Significant systemic inflammation developed in aging Nlrp3 mutant Il18r-null mice, indicating that IL-1 and IL-18 drive pathology at different stages of the disease process. Ongoing inflammation in double-cytokine knockout CAPS mice implicated a role for caspase-1-mediated pyroptosis and confirmed that CAPS is inflammasome dependent. Our results have important implications for patients with CAPS and residual disease, emphasizing the need to explore other NLRP3-mediated pathways and the potential for inflammasome-targeted therapy.

  17. Guido Paduano, Il testo e il mondo. Elementi di teoria della letteratura

    Directory of Open Access Journals (Sweden)

    Andrea Veglia

    2013-05-01

    Full Text Available Esistono categorie critiche che devono essere periodicamente rinegoziate e ridiscusse. È il caso di definizioni quali il letterario contrapposto al non-letterario, la volontà dell’autore, il ruolo del lettore nella creazione del significato di un testo, il valore delle opere di secondo grado, i rapporti testualità-mondo e testualità-uomo, il giudizio di valore. C’è periodicamente bisogno di creare dei percorsi che permettano di sottrarsi a una soffocante ipertrofia critica. Tutto questo, con un’attenzione alla semplicità del linguaggio e alla chiarezza espositiva, a volte però inficiata dal mancato riferimento a testi che seguano da vicino gli sviluppi più recenti del dibattito critico internazionale, è quanto si propone di fare Guido Paduano ne Il testo e il mondo. Elementi di teoria della letteratura. 

  18. IL-4 function can be transferred to the IL-2 receptor by tyrosine containing sequences found in the IL-4 receptor alpha chain.

    Science.gov (United States)

    Wang, H Y; Paul, W E; Keegan, A D

    1996-02-01

    IL-4 binds to a cell surface receptor complex that consists of the IL-4 binding protein (IL-4R alpha) and the gamma chain of the IL-2 receptor complex (gamma c). The receptors for IL-4 and IL-2 have several features in common; both use the gamma c as a receptor component, and both activate the Janus kinases JAK-1 and JAK-3. In spite of these similarities, IL-4 evokes specific responses, including the tyrosine phosphorylation of 4PS/IRS-2 and the induction of CD23. To determine whether sequences within the cytoplasmic domain of the IL-4R alpha specify these IL-4-specific responses, we transplanted the insulin IL-4 receptor motif (I4R motif) of the huIL-4R alpha to the cytoplasmic domain of a truncated IL-2R beta. In addition, we transplanted a region that contains peptide sequences shown to block Stat6 binding to DNA. We analyzed the ability of cells expressing these IL-2R-IL-4R chimeric constructs to respond to IL-2. We found that IL-4 function could be transplanted to the IL-2 receptor by these regions and that proliferative and differentiative functions can be induced by different receptor sequences.

  19. Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma

    Directory of Open Access Journals (Sweden)

    Liat Medina

    2014-01-01

    Full Text Available Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian tissues. Ovarian tissue samples were examined by immunohistochemical staining for IL-18, IL-18BP, and IL-18R and mRNA of these cytokines was analyzed with semiquantitative PT-PCR. IL-18 levels were significantly higher in cancerous ovarian tissues (P=0.0007, IL-18BP levels were significantly higher in normal ovarian tissues (P=0.04, and the ratio of IL-18/IL-18BP was significantly higher in cancerous ovarian tissues (P=0.036. Cancerous ovarian tissues expressed significantly higher IL-18 mRNA levels (P=0.025, while there was no difference in the expression of IL-18BP mRNA and IL-18R mRNA between cancerous and normal ovarian tissues. IL-18 and IL-18BP were expressed dominantly in the epithelial cells of both cancerous and normal ovarian tissues, while IL-18R was expressed dominantly in the epithelial cells of cancerous ovarian tissues but expressed similarly in the epithelial and stromal cells of normal cancerous tissues. This study indicates a possible role of IL-18, IL-18BP, and IL-18R in the pathogenesis of epithelial ovarian carcinoma.

  20. Distinct expression of interleukin (IL)-36α, β and γ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease.

    Science.gov (United States)

    Boutet, M-A; Bart, G; Penhoat, M; Amiaud, J; Brulin, B; Charrier, C; Morel, F; Lecron, J-C; Rolli-Derkinderen, M; Bourreille, A; Vigne, S; Gabay, C; Palmer, G; Le Goff, B; Blanchard, F

    2016-05-01

    Interleukin (IL)-36α, IL-36β and IL-36γ are expressed highly in skin and are involved in the pathogenesis of psoriasis, while the antagonists IL-36Ra or IL-38, another potential IL-36 inhibitor, limit uncontrolled inflammation. The expression and role of IL-36 cytokines in rheumatoid arthritis (RA) and Crohn's disease (CD) is currently debated. Here, we observed that during imiquimod-induced mouse skin inflammation and in human psoriasis, expression of IL-36α, γ and IL-36Ra, but not IL-36β and IL-38 mRNA, was induced and correlated with IL-1β and T helper type 17 (Th17) cytokines (IL-17A, IL-22, IL-23, CCL20). In mice with collagen-induced arthritis and in the synovium of patients with RA, IL-36α, β, γ, IL-36Ra and IL-38 were all elevated and correlated with IL-1β, CCL3, CCL4 and macrophage colony-stimulating factor (M-CSF), but not with Th17 cytokines. In the colon of mice with dextran sulphate sodium-induced colitis and in patients with CD, only IL-36α, γ and IL-38 were induced at relatively low levels and correlated with IL-1β and IL-17A. We suggest that only a minor subgroup of patients with RA (17-29%) or CD (25%) had an elevated IL-36 agonists/antagonists ratio, versus 93% of patients with psoriasis. By immunohistochemistry, IL-36 cytokines were produced by various cell types in skin, synovium and colonic mucosa such as keratinocytes, CD68⁺ macrophages, dendritic/Langerhans cells and CD79α⁺ plasma cells. In primary cultures of monocytes or inflammatory macrophages (M1), IL-36β and IL-36Ra were produced constitutively, but IL-36α, γ and IL-38 were produced after lipopolysaccharide stimulation. These distinct expression profiles may help to explain why only subgroups of RA and CD patients have a potentially elevated IL-36 agonists/antagonists ratio.

  1. Caravaggio e il Maccheronico di Teofilo Folengo

    Directory of Open Access Journals (Sweden)

    Bernardo Piciché

    2013-06-01

    Full Text Available Il presente studio ipotizza un’affinità tra Caravaggio e Teofilo Folengo, argomentando che la pittura del primo presenta analogie estetiche e etiche con la produzione in latino maccheronico del secondo. Il Baldus costituisce un tipico esempio di quella che Genette definirà come «parodia seria»: attraverso il rovesciamento e la irrisione beffarda Folengo ingaggia tenzone contro l’arte paludata e il travisamento dei valori cristiani. Non si tratta qui di stabilire un’influenza di Folengo su Caravaggio, bensì un’analogia, in virtù di un filo di congiunzione ideale, la cui presumibilità viene corroborata anche dal substrato biografico-culturale e da comune spirito religioso. Sia in Folengo che in Caravaggio sono stati individuati i caratteri di un certo modo della cultura lombarda di essere “contro” al punto che il duo Folengo-Caravaggio sembra epitomizzare l’antitesi al decorum curialcortigianesimo di Castiglione e Raffaello. Il Cristo-paradosso costituisce la vera fonte ispiratrice per entrambi. La comparazione tra due arti deve tenere conto dei diversi strumenti espressivi, e questo costituirà uno dei soggetti di riflessione nel testo. Se l’ipotesi della consentaneità viene ragionevolmente difesa, perché non individuare una componente maccheronica anche nell’arte di Caravaggio? Agli storici d’arte, tuttavia, decidere se si possa considerare il maccheronico come categoria pittorica

  2. Role of IL-2 in cancer immunotherapy.

    Science.gov (United States)

    Jiang, Tao; Zhou, Caicun; Ren, Shengxiang

    2016-06-01

    Interleukin-2 (IL-2) is one of the key cytokines with pleiotropic effects on immune system. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma. Recent progress has been made in our understanding of IL-2 in regulating lymphocytes that has led to exciting new directions for cancer immunotherapy. While improved IL-2 formulations might be used as monotherapies, their combination with other anticancer immunotherapies, such as adoptive cell transfer regimens, antigen-specific vaccination, and blockade of immune checkpoint inhibitory molecules, for example cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) mono-antibodies, would held the promise of treating metastatic cancer. Despite the comprehensive studies of IL-2 on immune system have established the application of IL-2 for cancer immunotherapy, a number of poignant obstacles remain for future research. In the present review, we will focus on the key biological features of IL-2, current applications, limitations, and future directions of IL-2 in cancer immunotherapy.

  3. Conducta típica e imputación objetiva en el delito de alzamiento de bienes: una contribución normativista a la dogmática de los delitos de insolvencia

    OpenAIRE

    2014-01-01

    La tesis contiene un análisis dogmático del tipo de alzamiento de bienes, cuyos puntos de partida y conclusiones pueden extenderse a los demás tipos penales que se encuentran dentro del género de las insolvencias punibles. Se comienza por un estudio del estado de la cuestión que incluye el objeto de protección y la forma de afectación del bien jurídico, criticando las posturas dominantes de la doctrina como de la jurisprudencia. En segundo lugar se aborda el problema relativo a la natural...

  4. IL-1β Inhibits Human Osteoblast Migration

    Science.gov (United States)

    Hengartner, Nina-Emily; Fiedler, Jörg; Ignatius, Anita; Brenner, Rolf E

    2013-01-01

    Bone has a high capacity for self-renewal and repair. Prolonged local secretion of interleukin 1β (IL-1β), however, is known to be associated with severe bone loss and delayed fracture healing. Since induction of bone resorption by IL-1β may not sufficiently explain these pathologic processes, we investigated, in vitro, if and how IL-1β affects migration of multipotent mesenchymal stromal cells (MSC) or osteoblasts. We found that homogenous exposure to IL-1β significantly diminished both nondirectional migration and site-directed migration toward the chemotactic factors platelet-derived growth factor (PDGF)-BB and insulinlike growth factor 1 (IGF-1) in osteoblasts. Exposure to a concentration gradient of IL-1β induced an even stronger inhibition of migration and completely abolished the migratory response of osteoblasts toward PDGF-BB, IGF-1, vascular endothelial growth factor A (VEGF-A) and the complement factor C5a. IL-1β induced extracellular signal-regulated kinases 1 and 2 (ERK1/2) and c-Jun N-terminal kinases (JNK) activation and inhibition of these signaling pathways suggested an involvement in the IL-1β effects on osteoblast migration. In contrast, basal migration of MSC and their migratory activity toward PDGF-BB was found to be unaffected by IL-1β. These results indicate that the presence of IL-1β leads to impaired recruitment of osteoblasts which might influence early stages of fracture healing and could have pathological relevance for bone remodeling in inflammatory bone disease. PMID:23508571

  5. Identification of residues involved in binding of IL5 to betacom using betaIL3 and betacom chimeras.

    Science.gov (United States)

    Czabotar, P E; Holland, J; Sanderson, C J

    1999-10-22

    In mice there are two forms of the beta chain used in the IL3 receptor system, betacom and betaIL3. betacom is used by the IL3, IL5 and GM-CSF receptors whereas betaIL3 is only used in the IL3 receptor. In this work an assay was developed to identify residues of beta1L3 that restrict IL5 activity. It was found that such residues reside within the 2nd CRM of the molecule. Furthermore, when residues in the betaIL3 B'-C' loop were replaced with betacom sequence a form of betaIL3 was produced that was able to respond to IL5. This region is also responsible for IL3 binding to betaIL3 in the absence of alpha chain. It is therefore an important structural motif of betacom and betaIL3 responsible for both ligand interaction and specificity.

  6. IL-33 induces IL-9 production in human CD4+ T cells and basophils

    DEFF Research Database (Denmark)

    Blom, Lars; Poulsen, Britta Cathrina; Jensen, Bettina M.

    2011-01-01

    IL-33, an IL-1 family member and ligand for the IL-1 receptor-related protein ST2, has been associated with induction of Th2 cytokines such as IL-4, IL-5, and IL-13. Here, we report that IL-33 can initiate IL-9 protein secretion in vitro in human CD4+ T cells and basophils isolated from periphera......, these data indicate that barrier functioning cells are important for the regulation of IL-9 production by immune cells in inflamed tissue....

  7. Single Nucleotide Polymorphisms in IL-10, IL-12p40, and IL-13 Genes and Susceptibility to Glioma.

    Science.gov (United States)

    Shamran, Haidar A; Ghazi, Haidar F; Al-Salman, Ahmed; Al-Juboory, Ahmad A; Taub, Dennis D; Price, Robert L; Nagarkatti, Mitzi; Nagarkatti, Prakash S; Singh, Udai P

    2015-01-01

    Glioma is one of the most aggressive and most common tumors of the central nervous system (CNS) in humans. The exact causes of glioma are not well known, but evidence suggests the involvement of genetic factors in addition to environmental risk factors. The present study aimed to determine whether polymorphisms in IL-10-1082A/G, IL-12p40 1188C/A, and IL-13+2044G/A (rs20541) are associated with the incidence of glioma in Iraqi patients. Ninety-six patients with different grades of glioma and 40 apparently healthy individuals were recruited. A blood sample and genomic DNA were collected from all subjects. The amplification refractory mutation system and sequence-specific primer polymerase chain reaction (PCR) were used for genotyping of IL-10-1082A/G and IL-12p40 1188C/A, respectively; whereas, the IL-13+2044G/A was detected by DNA sequencing after amplification of the genes by PCR. All SNPs were within Hardy-Weinberg equilibrium and each appeared in three genotypes in patients and controls. In IL-10-1082A/G, these genotypes frequencies were AA (75%), AG (22.93%) and GG (2.07%) in patients as compared to similar frequencies (62.5%), (27.5%) and (10%) respectively, in controls. The variant IL-12p40 1188C/A genotype was AA (72.92%), AC (23.96%), and CC (3.13%%) in patients as compared to 65%, 30%, and 5%, respectively, in controls. The frequencies of IL-13+2044G/A genotypes (GG, GA, and AA) were 89.58%, 9.37%, and 1.04% among patients versus 47.5%, 32.5% and 20%, respectively, among controls. These results suggest a protective role of mutant alleles G and A in IL-10-1082A/G and IL-13+2044G/A against gliomas. Further studies with more rigorous parameter designs will be needed to confirm the current findings.

  8. Religion et entertainment sont-ils compatibles?

    OpenAIRE

    Guy Marchessault

    2011-01-01

    Est-ce possible de réconcilier l’approche spectaculaire des médias avec la nature intérieure du spirituel? Peut-on imaginer la présence des religions dans une ambiance de divertissement? Il y a toujours eu tensions entre les religions et le jeu: elles craignaient le théâtre, les jeux, la musique, les arts, la danse, les jeux de cartes… et les médias, naturellement. Pourquoi l’entertainment fut-il considéré si dangereux? N’y aurait-il pas une approche plus positive qui permettrait de discerner...

  9. Google e il patrimonio culturale italiano

    Directory of Open Access Journals (Sweden)

    Elisa Bonacini

    2014-04-01

    Full Text Available ITIn questo lavoro si intende ricostruire il ruolo svolto dal motore di ricerca google nella moderna società culturale e, soprattutto, il ruolo svolto da google nella comunicazione e valorizzazione del patrimonio culturale italiano attraverso il cultural institute e tutti i software e gli applicativi che google mette a disposizione della cultura.ENAim of this paper is the reconstruction of google’s role in modern cultural society and, above all, its role through the google cultural institute and its many softwares and applications, for communication and dissemination of italian cultural heritage.

  10. Non-redundant properties of IL-1alpha and IL-1beta during acute colon inflammation in mice

    NARCIS (Netherlands)

    Bersudsky, M.; Luski, L.; Fishman, D.; White, R.M.; Ziv-Sokolovskaya, N.; Dotan, S.; Rider, P.; Kaplanov, I.; Aychek, T.; Dinarello, C.A.; Apte, R.N.; Voronov, E.

    2014-01-01

    OBJECTIVE: The differential role of the IL-1 agonists, IL-1alpha, which is mainly cell-associated versus IL-1beta, which is mostly secreted, was studied in colon inflammation. DESIGN: Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1alpha or IL-1beta, and in

  11. The IL-2 cytokine family in cancer immunotherapy.

    Science.gov (United States)

    Sim, Geok Choo; Radvanyi, Laszlo

    2014-08-01

    The use of cytokines from the IL-2 family (also called the common γ chain cytokine family) such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer patients is one of the most important areas of current cancer immunotherapy research. The infusion of IL-2 at low or high doses for multiple cycles in patients with metastatic melanoma and renal cell carcinoma was the first successful immunotherapy for cancer proving that the immune system could completely eradicate tumor cells under certain conditions. The initial clinical success observed in some IL-2-treated patients encouraged further efforts focused on developing and improving the application of other IL-2 family cytokines (IL-4, IL-7, IL-9, IL-15, and IL-21) that have unique biological effects playing important roles in the development, proliferation, and function of specific subsets of lymphocytes at different stages of differentiation with some overlapping effects with IL-2. IL-7, IL-15, and IL-21, as well as mutant forms or variants of IL-2, are now also being actively pursued in the clinic with some measured early successes. In this review, we summarize the current knowledge on the biology of the IL-2 cytokine family focusing on IL-2, IL-15 and IL-21. We discuss the similarities and differences between the signaling pathways mediated by these cytokines and their immunomodulatory effects on different subsets of immune cells. Current clinical application of IL-2, IL-15 and IL-21 either as single agents or in combination with other biological agents and the limitation and potential drawbacks of these cytokines for cancer immunotherapy are also described. Lastly, we discuss the future direction of research on these cytokines, such as the development of new cytokine mutants and variants for improving cytokine-based immunotherapy through differential binding to specific receptor subunits.

  12. Relationship Between Cysteine, Interleukin (Il-2, and Interleukin (Il-10 in Children with Marasmus Type Malnutrition

    Directory of Open Access Journals (Sweden)

    Teguh Wahyudi

    2016-04-01

    Full Text Available Malnutrition is one of the health issues in developing countries. The most commonly found malnutrition is the marasmus type. Infection in marasmus patient is the main cause of morbidity and mortality in developing countries. In marasmus, there is a decrease in protein level such as cysteine which is one of the glutathione forming components that plays a significant role in immune system. In malnutrition, there is a disturbance of lymphocyte in the form of down-regulation of type 1 cytokine (IL-2 and IFN-γ and up-regulation of type 2 cytokine (IL-4 and IL-10. IL-2 is needed for the development of regulatory T produced by thymus and for NK cell cytotoxicity which plays a role in infection process, while IL-10 inhibits activation of lymphocyte T so the cellular immunity reaction ends. Several studies about the relationship between cysteine, IL-2, and IL-10 have been done in malnutrition-patients, but there is no study focusing on patients with marasmus. This study is to find out the relationship between cysteine, IL-2, and IL-10 in patients with marasmus type malnutrition. This study was an observational analytic study using cross-sectional design consisting of 20 children with marasmus type malnutrition and 20 well-nourished children treated in Saiful Anwar Hospital Malang. The cysteine, IL-2, and IL-10 level then measured using Elisa method. Normality and the various test were done. The Pearson correlation test was done to find out the relationship between cysteine and IL-2 level, cysteine and IL-10 level, and IL-2 and IL-10. The standard of cysteine and IL-2 level in children with marasmus is significantly lower than the control group, which was 1.616 ± 1.039 vs 3.298 ± 0.519 pg/mL; p = 0.000 dan 12.38±4.94 vs. 16.58 ± 4.80 pg/mL; p = 0.010, respectively. IL-10 in children with marasmus was significantly higher than control group (19.08± 5.93 vs 10.46 ± 3.90 pg/mL; p = 0.000. The cysteine level was positively correlated to the IL-2 level

  13. IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6.

    Science.gov (United States)

    Wang, An-Jiang; Yang, Zhonghan; Grinchuk, Viktoriya; Smith, Allen; Qin, Bolin; Lu, Nonghua; Wang, Duan; Wang, Hongbing; Ramalingam, Thirumalai R; Wynn, Thomas A; Urban, Joseph F; Shea-Donohue, Terez; Zhao, Aiping

    2015-11-15

    IL-25 or IL-17E is a member of IL-17 cytokine family and has immune-modulating activities. The role of IL-25 in maintaining lipid metabolic homeostasis remains unknown. We investigated the effects of exogenous IL-25 or deficiency of IL-25 on hepatic lipid accumulation. IL-25 expression was examined in paraffin-embedded tissue sections of liver from patients or in the livers from mice. Mouse model of steatosis was induced by feeding a high-fat diet (HFD). Extent of steatosis as well as expression of cytokines, key enzymes for lipid metabolic pathways, markers for Kupffer cells/macrophages, and lipid droplet (LD) proteins, were analyzed. Our results show that hepatic steatosis in mice was accompanied by increased LD proteins, but decreased IL-25 in the liver. Decreased hepatic IL-25 was also observed in patients with fatty liver. Administration of IL-25 to HFD-fed wild-type mice led to a significant improvement in hepatic steatosis. This effect was associated with increased expression of IL-13, development of alternatively activated Kupffer cells/macrophages, and decreased expression of LD proteins in the liver. In contrast, administration of IL-25 to HFD-fed mice deficient in STAT6 or IL-13 had no effects. In addition, stimulation of primary hepatocytes with IL-13, but not IL-25, resulted in downregulation of LD proteins. Finally, mice deficient in IL-25 had exacerbated hepatic lipid accumulation when fed the HFD. These data demonstrate that dysregulated IL-25 expression contributes to lipid accumulation, whereas exogenous IL-25 protects against hepatic steatosis through IL-13 activation of STAT6. IL-25 and IL-13 are potential therapeutic agents for hepatic steatosis and associated pathologies.

  14. Ciencia prohibida... ciencia buscada (A propósito de La ciencia del bien y del mal de Javier Echeverría

    Directory of Open Access Journals (Sweden)

    Gómez Pin, Víctor

    2007-06-01

    Full Text Available A labyrinth was the infinite for Leibniz (who declares on several occasions that,as much from the angle of the infinite large as from that of the infinite small, infinity is nothing but a fiction in the attempts of thought to explain the phenomena. But another labyrinth was also for him the problem of the evilness, together with the correlative problem of goodness. Used, since he was a young mathematician, to the Leibnizian puzzle of the infinite, Javier Echeverría faces now the second labyrinth. And he approaches the subject by restoring the biblical myth of the tree that hides the mystery. Taken implicitly the opposite point of view that leads Kant to assert the intrinsic division of the reason, Echeverría, from the very title of his book, aims at goodness and evilness as effective goals for science. In this paper we discuss some implications of Echeverría’s bet.

    Un laberinto era el infinito para Leibniz (quien afirma en varias ocasiones que tanto lo infinitamente grande como lo infinitamente pequeño no son sino ficciones para el pensamiento que busca la explicación de los fenómenos pero laberinto era asimismo, para él, la cuestión del mal, indisociable de problema del bien. Curtido, desde sus años de joven matemático, en el leibniziano puzzle del infinito y el continuo, Javier Echeverría se confronta ahora al segundo laberinto. Y lo hace restaurando el bíblico relato del árbol cuyo fruto escondería el misterio. Tomando implícitamente una vía opuesta a la que conduce a la kantiana división de la razón, Echeverría apunta a hacer de la polaridad bien-mal objeto de efectiva ciencia. En este escrito discutimos alguna de las implicaciones de su apuesta.

  15. La Repercusión del Valor Razonable de los Bienes Inmuebles en la Utilidad de los Estados Financieros: Una Nota de Investigación

    Directory of Open Access Journals (Sweden)

    Andrés Navarro Galera

    2009-06-01

    Full Text Available La elección en la reciente reforma contable española del criterio de valor razonable en lugar del coste histórico como base de valoración para determinados activos ha generado cierta controversia. Este trabajo estudia la posible incidencia de la adopción del valor razonable para el registro contable de los bienes inmuebles sobre la relevancia y la fiabilidad de la información financiera. El estudio empírico está basado en una encuesta sobre las percepciones de 151 responsables de la contabilidad de empresas españolas del sector de la construcción sobre la utilidad y fiabilidad de la información financiera basada en el valor razonable. El análisis de los resultados nos ha permitido concluir que, respecto al coste histórico, los responsables de contabilidad perciben que el valor razonable de los bienes inmuebles generaría estados financieros más útiles para representar la imagen fiel del patrimonio de la empresa. No obstante, los encuestados conciben la información financiera bajo valor razonable como menos objetiva y verificable. Asimismo, hemos comprobado que el tamaño de la empresa puede influir en la opinión de la repercusión del valor razonable sobre la relevancia y fiabilidad de los estados financieros.The option in the recent Spanish regulation for fair value over historical cost, as the preferred measurement basis for some assets, has raised some controversy. This paper studies the effects on accounting information relevance and reliability of fair value accounting for investment properties. The empirical study is based on a questionnairebased survey of the perceptions of 151 Spanish accountants in the building industry about the usefulness and reliability of fair value accounting. The analysis of results allows us concluding that accountants perceive that the usefulness of financial statements increases when investment property is valued on a fair value basis, compared with a historical cost basis. However, respondents

  16. Expression of POSTN, IL-4, and IL-13 in Chronic Rhinosinusitis with Nasal Polyps.

    Science.gov (United States)

    Milonski, Jaroslaw; Zielinska-Blizniewska, Hanna; Majsterek, Ireneusz; Przybyłowska-Sygut, Karolina; Sitarek, Przemyslaw; Korzycka-Zaborowska, Barbara; Olszewski, Jurek

    2015-05-01

    Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most frequently encountered chronic nasal diseases with a significant impact on patient quality of life. The aim of our study was therefore to investigate the association between the POSTN, IL-4, and IL-13 gene expression and the nasal polyp development. The objective of this study was to determine differential expression of POSTN, IL-4, and IL-13 genes in the mucosa and polyps of 63 patients with CRSwNP and 23 chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) when compared with patients with nasal septum deviation (n=18) who were used as controls. The expression level was investigated using reverse transcription-polymerase chain reaction assays in the polyp tissue and the mucosa of paranasal sinus collected while undergoing functional endoscopic sinus surgery. Expression of the mRNAs of all three genes, IL-4, IL-13, and POSTN, was significantly greater in the paired tissues of CRS patients with NPs or without NPs than in control subjects, with highest levels of POSTN and IL-13 seen in CRSwNP. An increased level of POSTN, IL-4, and IL-13 gene expression may be related to the development of chronic rhinosinusitis with nasal polyps, but polyp formation seemed to be associated especially with POSTN and IL-13 expression.

  17. IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13.

    Directory of Open Access Journals (Sweden)

    Masanori Sawada

    Full Text Available IL-18 plays a key role in the pathogenesis of pulmonary inflammatory diseases including pulmonary infection, pulmonary fibrosis, lung injury and chronic obstructive pulmonary disease (COPD. However, it is unknown whether IL-18 plays any role in the pathogenesis of asthma. We hypothesized that overexpression of mature IL-18 protein in the lungs may exacerbate disease activities of asthma. We established lung-specific IL-18 transgenic mice on a Balb/c genetic background. Female mice sensitized- and challenged- with antigen (ovalbumin were used as a mouse asthma model. Pulmonary inflammation and emphysema were not observed in the lungs of naïve transgenic mice. However, airway hyperresponsiveness and airway inflammatory cells accompanied with CD4(+ T cells, CD8(+ T cells, eosinophils, neutrophils, and macrophages were significantly increased in ovalbumin-sensitized and challenged transgenic mice, as compared to wild type Balb/c mice. We also demonstrate that IL-18 induces IFN-γ, IL-13, and eotaxin in the lungs of ovalbumin-sensitized and challenged transgenic mice along with an increase in IL-13 producing CD4(+ T cells. Treatment with anti-CD4 monoclonal antibody or deletion of the IL-13 gene improves ovalbumin-induced airway hyperresponsiveness and reduces airway inflammatory cells in transgenic mice. Overexpressing the IL-18 protein in the lungs induces type 1 and type 2 cytokines and airway inflammation, and results in increasing airway hyperresponsiveness via CD4(+ T cells and IL-13 in asthma.

  18. Cytokine vaccination: neutralising IL-1alpha autoantibodies induced by immunisation with homologous IL-1alpha

    DEFF Research Database (Denmark)

    Svenson, M; Hansen, M B; Thomsen, Allan Randrup;

    2000-01-01

    High-affinity IgG autoantibodies (aAb) to IL-1alpha are among the most frequently found aAb to cytokines in humans. To establish an animal model with aAb to IL-1alpha, we immunised mice with recombinant murine IL-1alpha. Unprimed and Bacille Calmette-Guérin (BCG)-primed BALB/cA mice were vaccinated...... in mice by vaccination with recombinant murine IL-1alpha conjugated to PPD. Studies of the effects of IL-1alpha aAb in such animals may help clarify the importance of naturally occurring IL-1alpha aAb in humans and permit the evaluation of future therapies with cytokine aAb in patients...... with IL-1alpha coupled to purified protein derivative of tuberculin (PPD). Both unprimed and primed animals developed IgG aAb to IL-1alpha. These aAb persisted at high levels more than 100 days after vaccination and did not cross-react with murine IL-1beta. The induced anti-IL-1alpha aAb inhibited binding...

  19. The role of interleukin-5 (IL-5 in vivo: studies with IL-5 deficient mice

    Directory of Open Access Journals (Sweden)

    Klaus I Matthaei

    1997-12-01

    Full Text Available Eosinophil recruitment is a characteristic feature of a number of pathological conditions and was the topic of the recent International Symposium on allergic inflammation, asthma, parasitic and infectious diseases (Rio de Janeiro, June 3-5, 1996. Since interleukin5 (IL5 is believed to regulate the growth, differentiation and activation of eosinophils (Coffman et al. 1989, Sanderson 1992, the role of eosinophils and IL5 are closely linked. Although IL5 specifically regulates eosinophilia in vivo and this is its most well established activity, it is becoming clear that IL5 also has other biological effects. The recent derivation of an IL5 deficient mouse (Kopf et al. 1996, provides a model for exploring not only the role of IL5 and eosinophils but also other novel activities of IL5. Of note is that although the IL5 deficient mice cannot elicit a pronounced eosinophilia in response to inflammatory stimulation following aeroallergen challenge or parasite infection they still produce basal levels of eosinophils that appear to be morphologically and functionally normal. However, the basal levels of eosinophils appear insufficient for normal host defence as IL5 deficiency has now been shown to compromise defence against several helminth infections. In addition, IL5 deficient mice appear to have functional deficiencies in B-1 B lymphocytes and in IgA production.

  20. B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis.

    Science.gov (United States)

    Yilmaz, Vuslat; Oflazer, Piraye; Aysal, Fikret; Parman, Yeşim G; Direskeneli, Haner; Deymeer, Feza; Saruhan-Direskeneli, Güher

    2015-06-01

    B cells from myasthenia gravis (MG) patients with autoantibodies (Aab) against acetylcholine receptor (AChR), muscle-specific kinase (MuSK) or with no detectable Aab were investigated as cytokine producing cells in this study. B cells were evaluated for memory phenotypes and expressions of IL-10, IL-6 and IL-12A. Induced productions of IL-10, IL-6, IL-12p40, TNF-α and LT from isolated B cells in vitro were measured by immunoassays. MG patients receiving immunosuppressive treatment had higher proportions of memory B cells compared with healthy controls and untreated patients. With CD40 stimulation MG patients produced significantly lower levels of IL-10, IL-6. With CD40 and B cell receptor stimulation of B cells, TNF-α production also decreased in addition to these cytokines. The lower levels of these cytokine productions were not related to treatment. Our results confirm a disturbance of B cell subpopulations in MG subgroups on immunosuppressive treatment. B cell derived IL-10, IL-6 and TNF-α are down-regulated in MG, irrespective of different antibody productions. Ineffective cytokine production by B cells may be a susceptibility factor in dysregulation of autoimmune Aab production.

  1. Serum IL-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy.

    Science.gov (United States)

    Dąbrowski, Roman; Pastor, Josep; Szczubiał, Marek; Piech, Tomasz; Bochniarz, Mariola; Wawron, Władysław; Tvarijonaviciute, Asta

    2015-09-26

    Pyometra is a serious bacterial infection of the uterus affecting female dogs and manifests as an accumulation of pus in the uterine lumen. The aim of the study was to assess changes in serum interleukin (IL)-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy. Blood samples were collected from healthy bitches (controls) and bitches with pyometra before surgery, and 3 and 10 days after ovariohysterectomy. Before surgery, bitches with pyometra had significantly higher serum concentrations of IL-6 and IL-10 than the controls. After surgery, the serum concentration of IL-6 and IL-10 decreased significantly. In healthy dogs, the concentration of IL-6 and IL-10 showed a significant increase 3 days after surgery followed by a decrease on day 10. An increase in serum concentrations of IL-6 and IL-10 was present before surgery in bitches with pyometra and 3 days after ovariohysterectomy in healthy controls. Concentrations decreased after ovariohysterectomy and/or proper healing, suggesting that these cytokines can be useful for assessment of the postoperative period in bitches.

  2. Increased IL-20 and IL-24 target osteoblasts and synovial monocytes in spondyloarthritis.

    Science.gov (United States)

    Kragstrup, Tue Wenzel; Andersen, Morten Nørgaard; Schiøttz-Christensen, Berit; Jurik, Anne Grethe; Hvid, Malene; Deleuran, Bent

    2017-04-02

    The pathogenesis of spondyloarthritis (SpA) involves activation of the innate immune system, inflammation and new bone formation. The two cytokines IL-20 and IL-24 have been shown to link innate immune activation and tissue homeostasis. We hypothesized that these two cytokines are secreted as part of activation of the innate immune system and affect bone homeostasis in SpA. IL-20 and IL-24 were measured in plasma from axial SpA patients (n=83). Peripheral SpA patients (n=16) were included for in vitro cell culture studies. The plasma IL-20 and IL-24 levels were increased in SpA patients compared with healthy controls (HCs) by 57% and 83%, respectively (both p<0.0001). The Toll like receptor 4 induced secretion of the two cytokines was greater in SpA peripheral blood mononuclear cells (PBMCs) compared with HC PBMCs. IL-20 and IL-24 increased the production of monocyte chemo attractant protein-1 by activated SpA synovial fluid monocytes, decreased the production of dickkopf-1 by SpA fibroblast-like synovial cells and induced mineralization in human osteoblasts. Taken together, our findings indicate disease-aggravating functions of IL-20 and IL-24 in SpA. This article is protected by copyright. All rights reserved.

  3. IL-4 alpha chain receptor (IL-4Rα polymorphisms in allergic bronchopulmonary sspergillosis

    Directory of Open Access Journals (Sweden)

    Consolino Judy D

    2006-02-01

    Full Text Available Abstract Background Allergic bronchopulmonary aspergillosis occurs in 7–10% of cystic fibrosis (CF and 1–2% of asthmatic patients. HLA-DR restriction and increased sensitivity to IL-4 stimulation have been proposed as risk factors in these populations. Objective We examined for the presence of IL-4 receptor alpha chain (IL-4Rα single nucleotide polymorphisms (SNPs in ABPA and whether these accounted for increased sensitivity to IL-4 stimulation. Methods One extracellular (ile75val and four cytoplasmic IL-4Rα SNPs were analyzed in 40 CF and 22 asthmatic patients and in 56 non-ABPA CF and asthmatic patients. Sensitivity to IL-4 stimulation was measured by induction of CD23 expression on B cells. Results IL-4Rα SNPs were observed in 95% of ABPA patients. The predominant IL-4Rα SNP was the extracellular IL-4Rα SNP, ile75val, observed in 80% of ABPA patients. Conclusion The presence of IL-4Rα SNPs, principally ile75val, appears to be a genetic risk for the development of ABPA.

  4. Photodynamic therapy affects the expression of IL-6 and IL-10 in vivo

    Science.gov (United States)

    Gollnick, Sandra O.; Musser, David A.; Henderson, Barbara W.

    1998-05-01

    Photodynamic therapy (PDT), which can effectively destroy malignant tissue, also induces a complex immune response which potentiates anti-tumor immunity, but also inhibits skin contact hypersensitivity (CHS) and prolongs skin graft survival. The underlying mechanisms responsible for these effects are poorly understood, but are likely to involve meditation by cytokines. We demonstrate in a BALB/c mouse model that PDT delivered to normal and tumor tissue in vivo causes marked changes in the expression of cytokines interleukin (IL)-6 and IL-10. IL-6 mRNA and protein are rapidly and strongly enhanced in the PDT treated EMT6 tumor. Previous studies have shown that intratumoral injection of IL- 6 or transduction of the IL-6 gene into tumor cells can enhance tumor immunogenicity and inhibit tumor growth in experimental murine tumor systems. Thus, PDT may enhance local anti-tumor immunity by up-regulating IL-6. PDT also results in an increase in IL-10 mRNA and protein in the skin. The same PDT regime which enhances IL-10 production in the skin has been shown to strongly inhibit the CHS response. The kinetics of IL-10 expression coincide with the known kinetics of PDT induced CHS suppression and we propose that the enhanced IL-10 expression plays a role in the observed suppression of cell mediated responses seen following PDT.

  5. Oral Escherichia coli colonization factor antigen I fimbriae ameliorate arthritis via IL-35, not IL-27.

    Science.gov (United States)

    Kochetkova, Irina; Thornburg, Theresa; Callis, Gayle; Holderness, Kathryn; Maddaloni, Massimo; Pascual, David W

    2014-01-15

    A Salmonella therapeutic expressing enterotoxigenic Escherichia coli colonization factor Ag I (CFA/I) fimbriae protects against collagen-induced arthritis (CIA) by eliciting two regulatory T cell (Treg) subsets: TGF-β-producing Foxp3(-)CD39(+)CD4(+) T cells and IL-10-producing Foxp3(+)CD39(+)CD4(+) T cells. However, it is unclear whether CFA/I fimbriae alone are protective and whether other regulatory cytokines are involved, especially in the context for the EBI3-sharing cytokines, Treg-derived IL-35 and APC-derived IL-27, both capable of suppressing Th17 cells and regulating autoimmune diseases. Subsequent evaluation revealed that a single oral dose of purified, soluble CFA/I fimbriae protected against CIA as effectively as did Salmonella-CFA/I and found that Foxp3(+)CD39(+)CD4(+) T cells were the source of secreted IL-35, whereas IL-27 production by CD11c(+) cells was inhibited. Inquiring into their relevance, CFA/I fimbriae-treated IL-27R-deficient (WSX-1(-/-)) mice were equally protected against CIA as were wild-type mice, suggesting a limited role for IL-27. In contrast, CFA/I fimbriae-mediated protection was abated in EBI3(-/-) mice, accompanied by the loss of TGF-β- and IL-10-producing Tregs. Adoptive transfer of C57BL/6 CD39(+)CD4(+) T cells to EBI3(-/-) mice with concurrent CFA/I plus IL-35 treatment effectively stimulated Tregs suppressing proinflammatory collagen II-specific Th cells. In contrast, recipients cotransferred with C57BL/6 and EBI3(-/-) CD39(+)CD4(+) T cells and treated with CFA/I plus IL-35 were not protected, implicating the importance of endogenous IL-35 for conferring CFA/I-mediated protection. Thus, CFA/I fimbriae stimulate IL-35 required for the coinduction of TGF-β and IL-10.

  6. IL12B and IL23R gene SNPs in Japanese psoriasis.

    Science.gov (United States)

    Oka, Akira; Mabuchi, Tomotaka; Ikeda, Shigaku; Terui, Tadashi; Haida, Yuko; Ozawa, Akira; Yatsu, Keisuke; Kulski, Jerzy K; Inoko, Hidetoshi

    2013-11-01

    Psoriasis is a common human skin disease whereby abnormal production of inflammatory mediators is believed to play an important role in its pathogenesis. The IL12B gene, which encodes the shared IL-12p40 subunit in two cytokines, IL-12 and IL-23, and the IL23R gene, which encodes a subunit of the receptor for IL-23, were identified as psoriasis-susceptibility genetic factors in recent candidate gene and genome-wide association studies of Chinese and Europeans. Since there are significant differences in the incidence of psoriasis between Europeans and Japanese suggesting a genetic ethnic effect, we examined the association of IL12B and IL23R gene polymorphisms with psoriasis in a cohort of Japanese. In this study, we genotyped two SNPs (rs3212227 and rs6887695) in the IL12B gene and one SNP (rs11209026) in the IL23R gene using 560 Japanese psoriasis cases and 560 controls and compared our results with those previously published for Europeans and Asians. Our study showed significant associations between psoriasis and both IL12B gene SNPs, rs3212227 (odds ratio (OR) = 1.35, P = 4.94E-04) and rs6887695 (OR = 1.32, P = 2.00E-03), but no significant association between psoriasis and the IL23R SNP, rs11209026. Furthermore, a significant haplotype association was found for the IL12B gene protective haplotype C-C (OR = 0.71, P = 1.84E-04) in Japanese, as previously elucidated in the studies of European ancestry.

  7. Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia

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    Palladino Ilaria

    2012-08-01

    Full Text Available Abstract Background The pleiotropic pro-inflammatory cytokine Interleukin (IL-18 has been proposed to play a role in schizophrenia, since elevated circulating levels of its protein and altered frequencies of genetic variants in its molecular system are reported in schizophrenic patients. Methods We analyzed 77 patients with schizophrenia diagnosis (SCZ and 77 healthy control subjects (HC for serum concentration of both IL-18 and its natural inhibitor, the IL-18 binding protein (IL-18BP. Results We confirmed that serum levels of total IL-18 are significantly increased in SCZ, as compared to HC. However, due to a highly significant increase in levels of circulating IL-18BP in SCZ, as compared to HC, the levels of free, bioactive IL-18 are not significantly different between the two groups. In addition, the relationships between the levels of IL-18 and its inhibitor, as well as between the two molecules and age appear dissimilar for SCZ and HC. In particular, the elevated levels of IL-18BP, likely a consequence of the body’s attempt to counteract the early prominent inflammation which characterizes schizophrenia, are maintained in earlier and later stages of the disease. However, the IL-18BP elevation appears ineffective to balance the IL-18 system in younger SCZ patients, while in older patients the levels of circulating bioactive IL-18 are comparable to those of HC, if not lower. Conclusions In conclusion, these findings indicate that the IL-18 system is perturbed in schizophrenia, supporting the idea that this pro-inflammatory cytokine might be part of a pathway of genetic and environmental components for vulnerability to the disease.

  8. IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis.

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    Nikolaos Sismanopoulos

    Full Text Available Interleukin 9 (IL-9 has been implicated in mast cell-related inflammatory diseases, such as asthma, where vascular endothelial growth factor (VEGF is involved. Here we report that IL-9 (10-20 ng/ml induces gene expression and secretion of VEGF from human LAD2. IL-9 does not induce mast cell degranulation or the release of other mediators (IL-1, IL-8, or TNF. VEGF production in response to IL-9 involves STAT-3 activation. The effect is inhibited (about 80% by the STAT-3 inhibitor, Stattic. Gene-expression of IL-9 and IL-9 receptor is significantly increased in lesional skin areas of atopic dermatitis (AD patients as compared to normal control skin, while serum IL-9 is not different from controls. These results imply that functional interactions between IL-9 and mast cells leading to VEGF release contribute to the initiation/propagation of the pathogenesis of AD, a skin inflammatory disease.

  9. Bien rédiger

    CERN Document Server

    Humbert, Jean-Louis

    1992-01-01

    Vous avez à rédiger un rapport, un résumé, une note de service ou un compte rendu de réunion. Vous avez un examen écrit à préparer... Ce guide, enrichi de nombreux exercices, vous donne toutes les règles pour : . Formuler votre pensée . Structurer votre texte . Construire vos phrases . Choisir le mot juste.

  10. IL13 — EDRN Public Portal

    Science.gov (United States)

    From NCBI Gene: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008

  11. Il volto cosmopolita dell’Europa

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    Anna Taglioli

    2010-05-01

    Full Text Available Il saggio intende leggere l’Europa attraverso il concetto di cosmopolitismo che ne riflette la natura, la storia e le possibilità future. Idea e ideale etico-normativo di comunanza e di apertura alla differenza la nozione si trasforma in modalità ibride nel corso della storia europea e permette di visualizzare le dinamiche di resistenza e di mutamento che vanno componendo il percorso di unificazione. Da imperativo e progetto razionale il cosmopolitismo va riconfigurandosi come nuova modalità percettiva, acquista un valore empirico-analitico in una realtà che sembra farsi strutturalmente cosmopolita e apre la riflessione sulle trasformazioni democratiche dell’Unione e sul ruolo che è chiamata ad assolvere per rispondere alla sfide della contemporaneità.

  12. Tecnologia italiana per il vuoto spinto

    CERN Document Server

    2002-01-01

    "Ancora una volta ad aggiudicarsi un ambito riconoscimento internazionale e' un fisico italiano: Cristoforo Benvenuti ritirera' tra pochi giorni a Denver il premio Gaede-Langmuir che viene assegnato dalla American vacuum society" (1/2 page).

  13. Il viaggio gastronomico di Paolo Monelli

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    Alberto Salarelli

    2013-01-01

    Full Text Available Il ghiottone errante di Paolo Monelli, pubblicato nel 1935, rappresenta uno dei primi esempi di narrativa di viaggio in tema di enogastronomia, un genere destinato a grande successo nel secondo dopoguerra. In questo articolo, oltre a ripercorrere la vicenda biografica di Monelli, si sottolineano le relazioni tra Il ghiottone e la cultura gastronomica del regime fascista, e si evidenziano alcuni tratti caratteristici del suo stile di scrittura.

  14. Della poesia come amore per il mondo

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    Pino Menzio

    2013-06-01

    Full Text Available Si prendono in esame alcune analogie tra le posizioni etico-letterarie di Todorov e il concetto di pietas, al centro dell’ontologia debole di Gianni Vattimo. Nell’uno e nell’altro caso il punto di riferimento è la poetica di Rilke, che opera come modello diretto in Todorov, e in maniera più indiretta e implicita, attraverso la mediazione di Heidegger, in Vattimo.

  15. Il lavoro e le forme del fare

    Directory of Open Access Journals (Sweden)

    Carlo Sini

    2011-10-01

    Full Text Available

    Lavoro e conoscenza. La sessualità umana e il resto come prodotto economico. L'economia della vita eterna e il destino futuro del capitalismo.

    The essence of work and the structures of doing

    Work and knowledge. The human sexuality and the rest as economic products. The economy of eternal life and the future destination of capitalism.

  16. Increased Serum Levels of IL-28 and IL-29 and the Protective Effect of IL28B rs8099917 Polymorphism in Patients with Hashimoto's Thyroiditis.

    Science.gov (United States)

    Arpaci, Dilek; Karakas Celik, Sevim; Can, Murat; Cakmak Genc, Gunes; Kuzu, Fatih; Unal, Mustafa; Bayraktaroglu, Taner

    2016-10-01

    Hashimoto's thyroiditis (HT) is thought to result from decreased T helper type 2 (Th2) responses, leading to the progressive destruction of thyrocytes. IFN-λ1, -λ2, and -λ3 (also known as IL-29, IL-28A, and IL-28B, respectively) are recently described members of the IFN-λ family and have been shown to decrease the production of Th2 cytokines in vitro. However, the role and mechanism of IFN-λ1 in HT remain unknown. The purpose of this study was to examine whether IL29 and IL28B gene polymorphisms are susceptibility genes for the development of HT. Also, we investigated the effects of IL-29 and IL-28 serum levels in the pathogenesis of HT. Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, single-nucleotide polymorphisms (SNPs) of IL28B rs8099917 (IL28 G/T) and IL29 rs30461 (IL29 T/C) were studied in 99 patients with HT and 100 healthy controls. Considering the allelic distribution of the IL28 G/T polymorphism, a higher frequency of the G allele was observed in the control group versus the HT group. Thus, it was suggested that the G allele may be protective against HT pathogenesis (OR = 0.388, 95% CI = 0.217-0.693; p = 0.001). Our findings also demonstrated that there was a statistically significant difference in serum IL-28 and IL-29 levels between case and control groups (p < 0.001). Increased serum levels of IL-28 and IL-29 were found in patients with HT. However, we did not find a relationship between the IL29 gene polymorphism and HT. In conclusion, the IL28B gene polymorphism and serum IL-28 and IL-29 levels seem to play a role in the pathogenesis of HT.

  17. 黄芪有效部位对化疗性贫血小鼠细胞因子IL-2、 IL-4、 IL-6的影响%Effect of Effective Parts of Astragalus on Cytokines IL-2 IL-4and IL-6 of Chemotherapy-induced Anemic Mice

    Institute of Scientific and Technical Information of China (English)

    陈晶晶; 范颖; 张红梅; 林庶茹

    2011-01-01

    目的:探讨黄芪有效部位对化疗性贫血模型小鼠脾组织IL-2、IL-4、IL-6的影响.方法:采用ELISA 法测定脾组织IL-2、IL-4、IL-6含量.结果:模型组脾组织IL-2、IL-4含量下降,IL-6含量升高,均有统计学意义(P<0.05).各治疗组对化疗所致骨髓抑制性贫血的脾组织IL-2、IL-4、IL-6具有不同程度的调控作用.结论:IL-2、IL-4、IL-6与环磷酰胺所致骨髓抑制性贫血的免疫失调有关;黄芪及其有效部位对环磷酰胺引起的骨髓抑制性贫血引发的免疫损伤具有保护作用,并对IL-2、IL-4、IL-6的生成具有不同的调节机制.%Objective: To investigate effect of effective parts of astragalus on cytokines IL-2,IL-4 and IL-6 of chemotherapy-induced anemic mice. Methods : Enzyme-linked immunosorbent assay(ELISA) was applied to measure the content of IL-2, EL-4 and IL-6 in spleen. Results: In spleen of the model group, the content of IL-2 and IL-4 decreased, the content of IL-6 increased, both with significances in statistics(P<0.05). In each treated group, IL-2, IL-4 and IL-6 in spleen of chemotherapy-induced myelosuppression anemic mice are regulated in varying degree. Conclusion: There are relationship between immune disorders caused by cyclophosphamide-induced myelosuppression anemia and the content of IL-2, IL-4 and IL-6. Astragalus and its effective parts can protect immune injury caused by cyclophosphamide-induced myelosuppression anemia, also regulate the production of IL-2, IL-4 and IL-6 in different metabolism.

  18. Observation and study OH IL-1β,IL-2 and IL-10 in serum of inbred HFJ rats%近交系HFJ大鼠血清中IL-1β、IL-2和IL-10观察研究

    Institute of Scientific and Technical Information of China (English)

    段肖翠; 吕占军; 蔡月花; 王秀芳; 侯洁; 刘军须; 刘福英; 谢英

    2011-01-01

    目的 比较观察本实验室培育的近交系HFJ大鼠和Wistar大鼠血清中IL-1β、IL-2和IL-10的含量.方法 HFJ大鼠和远交群Wistar大鼠各10只,应用ELISA法分别检测其血清IL-1β、IL-2和IL-10水平.结果 HFJ大鼠血清中IL-1β、IL-2的含量与Wistar大鼠相比差异无统计学意义(P>0.05),HFJ大鼠血清中IL-10的含量高于Wistar大鼠组,差异有统计学意义(P<0.05).且HFJ大鼠的IL-1β、IL-2和IL-10总体离散度明显小于Wistar大鼠组.结论 HFJ大鼠血清IL-10高于Wistar大鼠且近交系HFJ大鼠的IL-1β、IL-2和IL-10,测定值较为均一,离散度均低于Wistar大鼠.%Objective To comparative study the contents of IL - 1β, IL -2 and IL -10 in serum of Wistar rats and high fecundity inbred HFJ rats bred in our lab. Metbod Selecting 10 cases of HFJ rats and 10 cases of Wistar rats, and using ELISA to detected IL - 1β. IL -2 and IL - 10 in serum of them. Results There was no difference between Wistar group and HFJ group at the level of IL - 1β and IL - 2 (P > 0. 05) . The level of IL - 10 in HFJ group was higher than that in Wistar group (P < 0. 05) . The overall dispersion of IL - 1β. IL -2 and IL - 10 in HFJ rats group was significantly lower than Wistar rats group. Conlcusions IL - 10 in HFJ was higher than Wistar rats, and the measured values of IL -1β IL - 2 and IL - 10 were more relatively uniform in HFJ, and the dispersion of IL - 1β, IL - 2 and IL - 10 in HFJ rats group was lower than Wistar rats group.

  19. Hacia una reconstrucción del diseño legislativo del inventario y avalúo de los bienes hereditarios en Cuba

    Directory of Open Access Journals (Sweden)

    Raúl José Vega Cardona

    2014-12-01

    Full Text Available El presente artículo parte de la necesidad de realizar un estudio sobre el contenido del inventario y avalúo como operación particional del caudal hereditario en Cuba, a raíz de las complejidades propias del instituto, las que no solo se manifiestan en el ámbito teórico doctrinal sino también en la configuración legal que del mismo hiciera el legislador cubano. En este sentido se aporta, a partir de una exposición doctrinal sobre el tema, un diagnóstico de las principales insuficiencias que en el ámbito sustantivo inciden en la deficitaria práctica de la determinación y valuación de los bienes hereditarios, y con ello el establecimiento de las posibles pautas que permitan perfeccionar el régimen jurídico de la institución objeto de análisis.

  20. Valoración económica de bienes públicos: estudio de caso del río Lerma, La Piedad, Michoacán

    Directory of Open Access Journals (Sweden)

    Faustino Gómez Sántiz

    2015-01-01

    Full Text Available el tramo del río Lerma, que atraviesa la zona metropoli-tana de La Piedad de Cabadas, Michoacán-Santa Ana Pacue-co, Guanajuato, tiene una longitud de 12.8 km. Actualmenteestá convertido en un canal de desechos, que ha incididoen la aparición de fuertes problemas de salud pública. Eneste estudio se utilizó el método de valoración contingentey el modelo logit para determinar el valor económico totalde este bien ambiental, y para analizar las variables de ladecisión sobre la disposición a pagar una contribución pararealizar mejoras, por parte de los beneficiarios de él. Dichovalor se estimó en más de 4 millones de pesos anuales, estoindica que de realizarse mejoras ambientales, la poblaciónse beneficiaría en la medida en que se lograra mitigar losefectos de la contaminación.

  1. Aspectos generales del régimen de los bienes del litoral marítimo. Competencias y limitaciones sobre el Derecho de propiedad

    Directory of Open Access Journals (Sweden)

    Sebastián Barreto Cifuentes

    2013-07-01

    Full Text Available El concepto de “propiedad”, tradicionalmente estudiado con la lógica del Derecho privado, ha sufrido cambios internos (la función social como núcleo esencial y externos (las limitaciones administrativas que hacen necesario estudiarlo con herramientas lógicas y metodológicas del Derecho público. Se debe considerar que un derecho absoluto e ilimitado no requiere mayor atención por parte de la disciplina del Derecho público. La armonización y articulación de los derechos del propietario con las competencias asignadas a las autoridades administrativas, exige una particular atención para proteger los derechos ciudadanos. En desarrollo de lo mencionado, se ha realizado un corto estudio sobre los bienes del litoral marítimo, en particular de las competencias asignadas a las autoridades administrativas sobre estas áreas, así como el límite de estas competencias. También se presentará el análisis de algunos casos reales y potenciales en los cuales se hace necesaria la aplicación de garantías procesales y sustanciales para el respeto de los derechos de los propietarios.

  2. Producción y consumo de bienes culturales: El caso de las artesanías urbanas de la Ciudad de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Mónica B. Rotman

    2002-12-01

    Full Text Available Este artículo tiene por objeto reseñar algunos de los principales aspectos de un fenómeno cultural citadino: las artesanías urbanas feriales de la Ciudad de Buenos Aires. La problemática abordada contempla las instancias de la producción artesanal, la circulación de estos bienes con énfasis en las Ferias como sitios privilegiados del intercambio y ámbitos relevantes de sociabilidad y el consumo de artesanías. Consideramos que este tipo de producción, que constituye un fenómeno complejo, conforma una práctica cultural heterodoxa, recreando con códigos propios la sociabilidad híbrida que inducen las ciudades contemporáneas.The objective of this article is to outline some of the main aspects of an urban cultural phenomenon: the urban handicrafts from fairs in Buenos Aires city. The issues this paper addresses are handicraft production, the circulation of these goods with emphasis on fairs as privileged places of exchange, sociability and handicraft consumption. I consider this type of production a complex phenomena that shapes an heterodox cultural practice, recreating through its own codes the hybrid sociability that contemporary cities induce.

  3. Validación del Índice de Bien-estar Personal en personas con enfermedad renal crónica

    Directory of Open Access Journals (Sweden)

    Luís Manuel Mota de Sousa

    Full Text Available Objetivo: verificar las propiedades psicométricas del Índice de bien-estar personal (IBP en personas con enfermedad renal crónica en programa de hemodiálisis. Método: Se trata de un estudio metodológico. La muestra aleatoria es constituida por 171 personas con Enfermedad Renal Crónica (ERC sometida a hemodiálisis en dos clínicas en la región de Lisboa, Portugal. La recogida de datos fue realizada entre mayo y junio de 2015. Se evaluaron las propiedades psicométricas: validad (constructo, predictiva convergente, y discriminativa, confiabilidad por medio de la consistencia interna (α de Cronbach y estabilidad (Coeficiente de Correlación de Spearman-Brown y Coeficiente de Correlación Intraclasse (CCI. Resultados: El IBP presenta una dimensión ajustada a los datos. La satisfacción con la salud es lo que más contribuye para el IBP. Tiene validad convergente con Felicidad Subjetiva y Afecto Positivo y Afecto Negativo. Tiene poder discriminativo en la nacionalidad. El a Cronbach fue de 0,82. Teste Re-teste para cuestionario 0, 92 e CCI= 0,95, para entrevista 0,85 y CCI= 0,89. Conclusiones: La versión portuguesa del IBP es válida y reproducible en personas con ERC, tanto por cuestionario como por entrevista.

  4. Aspectos generales del régimen de los bienes del litoral marítimo. Competencias y limitaciones sobre el Derecho de propiedad

    Directory of Open Access Journals (Sweden)

    Sebastián Barreto Cifuentes

    2013-06-01

    Full Text Available El concepto de “propiedad”, tradicionalmente estudiado con la lógica del Derecho privado, ha sufrido cambios internos (la función social como núcleo esencial y externos (las limitaciones administrativas que hacen necesario estudiarlo con herramientas lógicas y metodológicas del Derecho público. Se debe considerar que un derecho absoluto e ilimitado no requiere mayor atención por parte de la disciplina del Derecho público. La armonización y articulación de los derechos del propietario con las competencias asignadas a las autoridades administrativas, exige una particular atención para proteger los derechos ciudadanos. En desarrollo de lo mencionado, se ha realizado un corto estudio sobre los bienes del litoral marítimo, en particular de las competencias asignadas a las autoridades administrativas sobre estas áreas, así como el límite de estas competencias. También se presentará el análisis de algunos casos reales y potenciales en los cuales se hace necesaria la aplicación de garantías procesales y sustanciales para el respeto de los derechos de los propietarios.

  5. FRNK negatively regulates IL-4-mediated inflammation.

    Science.gov (United States)

    Sharma, Ritu; Colarusso, Pina; Zhang, Hong; Stevens, Katarzyna M; Patel, Kamala D

    2015-02-15

    Focal adhesion kinase (FAK)-related nonkinase (PTK2 isoform 6 in humans, hereafter referred to as FRNK) is a cytoskeletal regulatory protein that has recently been shown to dampen lung fibrosis, yet its role in inflammation is unknown. Here, we show for the first time that expression of FRNK negatively regulates IL-4-mediated inflammation in a human model of eosinophil recruitment. Mechanistically, FRNK blocks eosinophil accumulation, firm adhesion and transmigration by preventing transcription and protein expression of VCAM-1 and CCL26. IL-4 activates STAT6 to induce VCAM-1 and CCL26 transcription. We now show that IL-4 also increases GATA6 to induce VCAM-1 expression. FRNK blocks IL-4-induced GATA6 transcription but has little effect on GATA6 protein expression and no effect on STAT6 activation. FRNK can block FAK or Pyk2 signaling and we, thus, downregulated these proteins using siRNA to determine whether signaling from either protein is involved in the regulation of VCAM-1 and CCL26. Knockdown of FAK, Pyk2 or both had no effect on VCAM-1 or CCL26 expression, which suggests that FRNK acts independently of FAK and Pyk2 signaling. Finally, we found that IL-4 induces the late expression of endogenous FRNK. In summary, FRNK represents a novel mechanism to negatively regulate IL-4-mediated inflammation.

  6. Diagnostic Value of IL-17 and IL-23 in Cerebrospinal Fluid in Bacterial Meningitis%脑脊液IL-17和IL-23检测在诊断细菌性脑膜炎中的意义

    Institute of Scientific and Technical Information of China (English)

    卜跃华; 解芳

    2012-01-01

    Objective To study IL-17 and IL-23 in the differentia] diagnosis of bacterial and viral meningitis. Methods The levels of IL-17 and IL-23 in cerebrospinal fluid of 64 cases were measured by ELISA method. The optimal cut-ofls of IL-17 and IL-23 were identified by using ROC curve. The correlation among IL-17,IL-23 and WBC count were evaluated using linear regression. Results The levels of IL-17 and IL-23 in cerebrospinal fluid were higher in bacterial meningitis than in viral meningitis and the control (P< 0.01),and the levels of IL-17 and IL-23 were higher in viral meningitis than the control (P< 0.01). The correlations of IL-17 and IL-23,IL-17 and WBC count, IL-23 and WBC count were 0.4980,0.5351 and 0.5810,respectively. Conclusion IL-17 and IL-23 in cerebrospinal fluid in the differential diagnosis of bacterial and other meningitis has clinical application value.%目的 探讨脑脊液IL-17和IL-23检测在细菌性脑膜炎中的诊断价值.方法 对64份脑脊液进行白细胞计数和IL-17、IL-23的检测.应用受试者工作特征曲线(ROC)对其诊断价值进行评价,并采用直线回归方法进行相关性分析.结果 细菌性脑膜炎组脑脊液IL-17和IL-23水平明显高于病毒性脑膜炎组和对照组(P<0.01),病毒性脑膜炎组IL-17和IL-23水平高于对照组(P<0.01).脑脊液IL-17与IL-23、IL-17与白细胞计数、IL-23与白细胞计数呈明显正相关,相关系数分别为04980、0.5551和0.5810.结论 脑脊液IL-17和IL-23的检测可以用于对细菌性脑膜炎的鉴别诊断.

  7. Research Advancement on Exercise and IL-6%运动与IL-6的研究进展

    Institute of Scientific and Technical Information of China (English)

    王今越; 丁树哲; 刘伟; 王小虹

    2007-01-01

    通过文献资料调研,总结并分析以往至最新的IL-6研究成果,从运动与肌源性IL-6 、运动与不同类型肌纤维IL-6的生成、运动训练与IL-6及IL-6R系统、运动模式与IL-6、糖代谢与IL-6、IL-6与抗氧化剂VC、VE、IL-6与IL-8、IL-6与SOCS-3几个方面论述运动介导下,IL-6的生成特点、影响因素和生物学功能.

  8. IL-1β and IL-6 modulate apolipoprotein E gene expression in rat hepatocyte primary culture

    Directory of Open Access Journals (Sweden)

    Agnes Ribeiro

    1992-01-01

    Full Text Available Incubation of rat hepatocytes in primary culture with IL-1β at a concentration of 2.5 units/ml resulted in an increase (+80% in the amount of apoE mRNA without any effect upon apoE synthesis. IL-6 at a low concentration (10 units/ml induced a decrease (−35% in the amount of apoE mRNA, but increased apoE synthesis (+28%. No effect was observed with higher concentrations of IL-1β (10 units/ml or IL-6 (100 units/ml. These results suggest that inflammatory cytokines IL-1β and IL-6 modulate the expression of apoE gene in cultured rat hepatocytes, at a concentration that does not induce the acute phase response.

  9. Cytokine vaccination: neutralising IL-1alpha autoantibodies induced by immunisation with homologous IL-1alpha

    DEFF Research Database (Denmark)

    Svenson, M; Hansen, M B; Thomsen, A R;

    2000-01-01

    High-affinity IgG autoantibodies (aAb) to IL-1alpha are among the most frequently found aAb to cytokines in humans. To establish an animal model with aAb to IL-1alpha, we immunised mice with recombinant murine IL-1alpha. Unprimed and Bacille Calmette-Guérin (BCG)-primed BALB/cA mice were vaccinated...... in mice by vaccination with recombinant murine IL-1alpha conjugated to PPD. Studies of the effects of IL-1alpha aAb in such animals may help clarify the importance of naturally occurring IL-1alpha aAb in humans and permit the evaluation of future therapies with cytokine aAb in patients...... with immunoinflammatory diseases and cytokine-dependent tumours....

  10. Un database per il controllo della vulnerabilità sismica: il caso studio di Acciano

    Directory of Open Access Journals (Sweden)

    Stefano Bertocci

    2012-11-01

    Full Text Available Il costante e continuo ripetersi di sismi sul territorio italiano ripropone puntualmente le problematiche legate alla prevenzione. Il sisma abruzzese e ancor più il sisma emiliano hanno dato la misura di come il nostro territorio sia fragile ma anche di come il sisma colpisca indistintamente edilizia storica ed edilizia moderna, compresa anche quella produttiva che di norma è più controllata e si rinnova con più facilità. Il problema di analizzare, studiare, censire, catalogare e archiviare le informazioni legate ai centri storici e alle stratificazioni che li contraddistinguono è noto, infatti spesso un gran numero di informazioni, rilevate durante la redazione di ricerche e studi o ancora più banalmente nella redazione degli elaborati legati alla presentazione di pratiche edilizie, si sperdono perché non archiviate correttamente o perché non si sfruttano le potenzialità dei programmi di archiviazione e gestione dei dati.

  11. Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion.

    Science.gov (United States)

    Wu, David; Ahrens, Richard; Osterfeld, Heather; Noah, Taeko K; Groschwitz, Katherine; Foster, Paul S; Steinbrecher, Kris A; Rothenberg, Marc E; Shroyer, Noah F; Matthaei, Klaus I; Finkelman, Fred D; Hogan, Simon P

    2011-04-15

    Interleukin-13 (IL-13) has been linked to the pathogenesis of inflammatory diseases of the gastrointestinal tract. It is postulated that IL-13 drives inflammatory lesions through the modulation of both hematopoietic and nonhematopoietic cell function in the intestine. To delineate the relevant contribution of elevated levels of intestinal IL-13 to intestinal structure and function, we generated an intestinal IL-13 transgenic mouse (iIL-13Tg). We show that constitutive overexpression of IL-13 in the small bowel induces modification of intestinal epithelial architecture (villus blunting, goblet cell hyperplasia, and increased epithelial proliferation) and epithelial function (altered basolateral → apical Cl(-) ion conductance). Pharmacological analyses in vitro and in vivo determined that elevated Cl(-) conductance is mediated by altered cystic fibrosis transmembrane conductance regulator expression and activity. Generation of iIL-13Tg/Il13rα1(-/-), iIL-13Tg/Il13rα2(-/-), and iIL-13Tg/Stat6(-/-) mice revealed that IL-13-mediated dysregulation of epithelial architecture and Cl(-) conductance is dependent on IL-13Rα1 and STAT-6. These observations demonstrate a central role for the IL-13/IL-13Rα1 pathway in the regulation of intestinal epithelial cell Cl(-) secretion via up-regulation of cystic fibrosis transmembrane conductance regulator, suggesting an important role for this pathway in secretory diarrhea.

  12. 胃癌患者血清中 IL-2,IL-4和 IL-6的动态分析及临床意义

    Institute of Scientific and Technical Information of China (English)

    孙景春; 李锐

    2013-01-01

    目的:探讨胃癌患者血清中 IL-2,IL-4和 IL-6的动态变化及临床意义;方法:应用 ELISA 的方法检测手术前后胃癌患者血清中 IL-2, IL-4和 IL-6的水平,并与良性肿瘤患者和健康体检者(对照组)进行比较.结果:胃癌患者在手术前,IL-4和 IL-6的水平高于良性肿瘤组和对照组(P<0.05),IL-2的水平低于良性肿瘤组和对照组(P<0.05);而在手术后 IL-4和 IL-6的水平明显降低,IL-2的水平呈现升高趋势,与对照组水平接近.结论:胃癌病人存在免疫功能的紊乱,IL-2,IL-4和 IL-6的水平变化参与了胃癌的发生、发展过程,对胃癌患者的诊断和预后判断具有重要的指导意义.

  13. Submerged cultivation of Ganoderma lucidum and the effects of its polysaccharides on the production of human cytokines TNF-α, IL-12, IFN-γ, IL-2, IL-4, IL-10 and IL-17.

    Science.gov (United States)

    Habijanic, Jožica; Berovic, Marin; Boh, Bojana; Plankl, Mojca; Wraber, Branka

    2015-01-25

    An original strain of Ganoderma lucidum (W.Curt.:Fr.) Lloyd, MZKI G97 isolated from Slovenian habitats was grown by a submerged liquid substrate cultivation in a laboratory stirred tank reactor. Five fractions of extracellular and cell-wall polysaccharides were obtained by extraction, ethanol precipitation, and purification by ion-exchange, gel and affinity chromatography. The capacity of isolated polysaccharide fractions to induce innate inflammatory cytokines, and to modulate cytokine responses of activated lymphocytes was investigated. Human peripheral blood mononuclear cells (PBMC) were activated in vitro with polysaccharide fractions, in order to induce innate inflammatory cytokines: tumor necrosis factor alpha (TNF-α), interleukin (IL) 12 and interferon gamma (IFN-γ). For the immunomodulation capacity, polysaccharide fractions were cultured with ionomycine and phorbol myristate acetate (IONO+PMA) activated PBMC, and the concentrations of induced IL-2, IL-4, IFN-γ, IL-10 and IL-17 were measured. The results showed that polysaccharides from G. lucidum induced moderate to high amounts of innate inflammatory cytokines. Fungal cell-wall polysaccharides were stronger innate inflammatory cytokines inducers, while extracellular polysaccharides demonstrated a higher capacity to modulate cytokine responses of IONO+PMA induced production of IL-17. The results indicate that G. lucidum polysaccharides enhance Th1 response with high levels of IFN-γ and IL-2, and display low to no impact on IL-4 production. A similar pattern was observed at regulatory cytokine IL-10. All of the polysaccharide fractions tested induced IL-17 production at different concentration levels.

  14. Il linguaggio, l’immagine ed il futuro dell’umano

    Directory of Open Access Journals (Sweden)

    Rodolfo Eduardo Scachetti

    2008-07-01

    Full Text Available Si discute in quest’articolo il desiderio della tecnoscienza di superare l’umano attuale. Il pensiero-limite è il post-umano ed occorre provare a conoscere soprattutto le prospettive delle metamorfosi tecnologiche del corpo. La questione è la seguente: i nuovi modelli conoscitivi fondati sulle immagini predomineranno o rafforzeranno le capacità tradizionali dell’essere umano?

  15. Bienes básicos, mercancía patrón y tasa de ganancia en Piero Sraffa Basic goods, standard commodity and the rate of profit in Piero Sraffa

    Directory of Open Access Journals (Sweden)

    Supelano Sarmiento Alberto

    1996-06-01

    Full Text Available Este ensayo describe el papel de los bienes básicos y la mercancía patrón en el esquema de precios de producción propuesto por Piero Sraffa. Su tema central son los problemas relacionados con la interpretación de Homero Cuevas: la importancia de los bienes básicos y de los bienes de lujo en la determinación de los precios y la distribución del excedente; la composición y el papel de la mercancía patrón; las limitaciones de la distinción entre los dos tipos de bienes y del concepto de mercancía patrón y la supuesta imposibilidad de construir la mercancía patrón.This essay describes the role of basic goods and the standard commodity in the prices of production scheme proposed by Piero Sraffa. Its central theme concerns the problems related to the interpretation of Homero Cuevas: the importance of basic goods and luxury goods in the determination of prices and the distribution of the surplus; the composition and role of the standard commodity; the limitations of the distinction between the two types of goods and theconcept of standard commodity and the supposed impossibility of constructing the standard commodity.

  16. [Serum levels of IL-10 and IL-35 in Yusho patients].

    Science.gov (United States)

    Koike, Yuta; Kuwatsuka, Yutaka; Shimizu, Kazuhiro; Utani, Atsushi

    2013-04-01

    We thought that dioxin and dioxin-like compound receptor AhR expressed on the surface of regulatory T (Treg) cells and Th17 cells could regulate immunological functions in the Yusho patients. In the present study, we measured Treg cell related cytokines IL-10 and IL-35 in the Yusho patients. Serum levels of IL-10 were higher, but not significant (p = 0.06), and serum levels of IL-35 were increased (p = 0.006) in comparison with healthy controls. These results imply Treg cell activation in the Yusho patients.

  17. IL-15/IL-15 receptor biology: a guided tour through an expanding universe.

    Science.gov (United States)

    Budagian, Vadim; Bulanova, Elena; Paus, Ralf; Bulfone-Paus, Silvia

    2006-08-01

    The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance.

  18. Extracellular IL-33 cytokine, but not endogenous nuclear IL-33, regulates protein expression in endothelial cells.

    Science.gov (United States)

    Gautier, Violette; Cayrol, Corinne; Farache, Dorian; Roga, Stéphane; Monsarrat, Bernard; Burlet-Schiltz, Odile; Gonzalez de Peredo, Anne; Girard, Jean-Philippe

    2016-10-03

    IL-33 is a nuclear cytokine from the IL-1 family that plays important roles in health and disease. Extracellular IL-33 activates a growing number of target cells, including group 2 innate lymphoid cells, mast cells and regulatory T cells, but it remains unclear whether intracellular nuclear IL-33 has additional functions in the nucleus. Here, we used a global proteomic approach based on high-resolution mass spectrometry to compare the extracellular and intracellular roles of IL-33 in primary human endothelial cells, a major source of IL-33 protein in human tissues. We found that exogenous extracellular IL-33 cytokine induced expression of a distinct set of proteins associated with inflammatory responses in endothelial cells. In contrast, knockdown of endogenous nuclear IL-33 expression using two independent RNA silencing strategies had no reproducible effect on the endothelial cell proteome. These results suggest that IL-33 acts as a cytokine but not as a nuclear factor regulating gene expression in endothelial cells.

  19. Critical appraisal of four IL-6 immunoassays.

    Directory of Open Access Journals (Sweden)

    Dana K Thompson

    Full Text Available BACKGROUND: Interleukin-6 (IL-6 contributes to numerous inflammatory, metabolic, and physiologic pathways of disease. We evaluated four IL-6 immunoassays in order to identify a reliable assay for studies of metabolic and physical function. Serial plasma samples from intravenous glucose tolerance tests (IVGTTs, with expected rises in IL-6 concentrations, were used to test the face validity of the various assays. METHODS AND FINDINGS: IVGTTs, administered to 14 subjects, were performed with a single infusion of glucose (0.3 g/kg body mass at time zero, a single infusion of insulin (0.025 U/kg body mass at 20 minutes, and frequent blood collection from time zero to 180 minutes for subsequent Il-6 measurement. The performance metrics of four IL-6 detection methods were compared: Meso Scale Discovery immunoassay (MSD, an Invitrogen Luminex bead-based multiplex panel (LX, an Invitrogen Ultrasensitive Luminex bead-based singleplex assay (ULX, and R&D High Sensitivity ELISA (R&D. IL-6 concentrations measured with MSD, R&D and ULX correlated with each other (Pearson Correlation Coefficients r = 0.47-0.94, p<0.0001 but only ULX correlated (r = 0.31, p = 0.0027 with Invitrogen Luminex. MSD, R&D, and ULX, but not LX, detected increases in IL-6 in response to glucose. All plasma samples were measurable by MSD, while 35%, 1%, and 4.3% of samples were out of range when measured by LX, ULX, and R&D, respectively. Based on representative data from the MSD assay, baseline plasma IL-6 (0.90 ± 0.48 pg/mL increased significantly as expected by 90 minutes (1.29 ± 0.59 pg/mL, p = 0.049, and continued rising through 3 hours (4.25 ± 3.67 pg/mL, p = 0.0048. CONCLUSION: This study established the face validity of IL-6 measurement by MSD, R&D, and ULX but not LX, and the superiority of MSD with respect to dynamic range. Plasma IL-6 concentrations increase in response to glucose and insulin, consistent with both an early glucose-dependent response (detectable at 1

  20. Decreased serum IL-27 and IL-35 levels are associated with disease severity in neuromyelitis optica spectrum disorders.

    Science.gov (United States)

    Zhang, Da-Qi; Jia, Kun; Wang, Rong; Li, Ting; Zhao, Ning; Yang, Li-Na; Yang, Li

    2016-04-15

    The interleukin 12 (IL-12) family plays important roles in autoimmune diseases. To explore the roles of the IL-12 family members IL-27 and IL-35 in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD), we determined their serum and cerebral spinal fluid levels and assessed potential correlations with clinical characteristics. Serum IL-27 levels were negatively correlated with disease severity and spinal cord lesion length, while serum IL-35 levels were negatively correlated with disease severity and annual relapse rate. Thus, IL-27 and IL-35 may be important biomarkers of NMOSD severity and these molecules might represent potential therapeutic cytokines for treating NMOSD.

  1. Profile of IL-2, IL-4, IL-10, IFN- ? , TNF- ? and KC-like cytokines in pregnant bitches

    Directory of Open Access Journals (Sweden)

    M.A.R. Feliciano

    2014-08-01

    Full Text Available The aim of this study was to determine the profile of IL-2, IL-4, IL-10, IFN-γ, and TNF-α cytokines and KC-like cells (natural killer in pregnant bitches, unpublished values for the species. A total of 27 females of the Shi Tzu, Pug, English Bulldog and French breeds, weighing 4-20kg and aged 4-6 years were used. Blood samples were collected from bitches during the anestrous and on the 2nd, 5th, 6th, 7th and 8th week of pregnancy. Serum levels of cytokines were measured by panel MILLIPLEX MAP (CCYTO-90K, MILLIPORE, Billerica, Massachusetts, USA validated for dogs. Twenty four females showed physiological pregnancy and three bitches showed pathological pregnancy. There was no difference between cytokine values during anestrous and gestational weeks of bitches (P>0.05. However, it was possible to verify the physiological behavior of serum levels during modulation of immune response in the gestational process of animals. In animals with gestational disorders, abnormal values for IL-2, IL-4 and INF-y were noted. It was concluded that serum levels of cytokines evaluated in pregnant bitches can help the better understanding of physiological and pathological gestational processes and correlated immunology in this species.

  2. The effects of IL-13 on the expressions of IL-13 receptors and IL-4 receptor in fibroblasts%IL-13对成纤维细胞IL-13受体和IL-4受体表达的影响

    Institute of Scientific and Technical Information of China (English)

    石小玉; 陈厚文; 熊慧玲; 王志刚; 赵林; 李文林

    2012-01-01

    Cytokine interleukin-13 (IL-13) is critical for organ fibrosis. IL-13 receptor alpha 1 (IL-13Rα1) and IL-4 receptor (IL-4R) form a functional IL-13 receptor complex that is thought to mediate most IL-13-induced effects. However, IL-13 receptor alpha 2 (IL-13Rα2), the high affinity receptor for IL-13, is thought to act as a decoy receptor for IL-13. This study aimed to investigate whether the fibrosis-related fibroblast could express IL-13Rα1, IL-4R or IL-13Rα2 and whether IL-13 could regulate the expressions of these receptors. The expressions of IL-13Rα1, IL-4R and IL-13Rα2 mRNA were detected by RT-PCR in human lung fibroblast line HFL-1 and human hepatic stellate cell line LX-2. The luminous intensity of RT-PCR electrophoresis strips was analyzed by gel quantitative software Image Tool 2.0. The expressions of soluble IL-13Rα2, total IL-13Rα1, IL-4R and IL-13Rα2 were measured by ELISA in the supernatant or lysate of HFL-1 cells and LX-2 cells. We found that IL-13 (5 to 100 ng/ml) had no effect on the expressions of IL-13Rα1 and IL-4R in HFL-1 cells and LX-2 cells. IL-13 Rα2 expression of HFL-1 cells was induced in dose-dependent manner under the circumstance of low concentrations of 5 to 20 ng/ml IL-13. However, IL-13Rα2 expression of HFL-1 cells was significantly decreased by using 50 ng/ml of IL-13 as compare with 20 ng/ml of IL-13 group, and could not be induced by using 100 ng/ml of IL-13. On the other hand, IL-13Rα2 expression was not found in LX-2 cells and the stimulation of IL-13 could not induce its expression. These results demonstrate that IL-13 can not up-regulate the expression of IL—13Rα1 and IL-4R, a functional IL-13 receptor complex, in human lung fibroblast line HFL-1 and human hepatic stellate cell line LX-2, indicating that IL-13 can not enlarge their own function by means of increasing IL-13Rα1 and IL-4R expressions. The results also show that certain concentrations of IL-13 can induce the expression of IL-13Rα2, an inhibitory

  3. IL-10-- and IL-20--expressing epithelial and inflammatory cells are increased in patients with ulcerative colitis.

    Science.gov (United States)

    Fonseca-Camarillo, Gabriela; Furuzawa-Carballeda, Janette; Llorente, Luis; Yamamoto-Furusho, Jesús K

    2013-04-01

    Interleukin (IL)-20, a pro-inflammatory cytokine, is a recently discovered member of the IL-10 family. This cytokine has been described in inflammatory diseases such as psoriasis and asthma. However, IL-20 expression in ulcerative colitis (UC) patients has not been yet described. The aim of this study was to evaluate IL-20 and IL-10 gene and protein expression and their receptors in the mucosa from UC patients. Forty UC patients and 18 non-inflamed controls were studied. IL-10, IL-20, IL-10R1, IL-10R2, IL-20R1 and IL-20R2 gene expression was determined by real time RT-PCR in colonic biopsies. Protein expression was evaluated by immunohistochemistry. Patients in remission had significantly higher IL-10 gene expression in mucosa compared with active patients and controls. Conversely, IL-10R1/B gene expression was decreased in remission compared with active UC patients and controls. IL-20 gene expression was lower in colonic mucosa from UC patients in remission compared with controls and active patients. IL-20R1/B mRNA expression was higher in remission compared with active UC patients and controls. IHQ analysis showed an increased IL-10-, IL-20-, and IL-20R2-producing cells in active UC patients. IL-10-, IL-20- and IL-20R2-expressing epithelial and inflammatory cells were increased in active UC patients, meanwhile IL-20R1 was up-regulated only on inflammatory infiltrates vs. controls. This is the first depiction of the presence of IL-20 and its receptors in UC. Much remains to be learned however, about the pathogenic mechanisms that lead to IBD. This cytokine/receptor imbalance may be implicated in the pathogenesis of UC.

  4. Three-Dimensional Conformal Radiotherapy in Prostate Cancer Patients: Rise in Interleukin 6 (IL-6) but not IL-2, IL-4, IL-5, Tumor Necrosis Factor-{alpha}, MIP-1-{alpha}, and LIF Levels

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira Lopes, Carlos [Universidade do Vale do Paraiba, Centro de Oncologia Radioterapica do Vale do Paraiba, Universidade do Vale do Paraiba Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraiba, Sao Jose dos Campos, Sao Paulo (Brazil); Callera, Fernando, E-mail: fcallera@gmail.com [Centro de Hematologia Onco-hematologia e Transplantes de Medula Ossea do Vale do Paraiba, Sao Paulo (Brazil)

    2012-03-15

    Purpose: To investigate the effect of radiotherapy (RT) on serum levels of interleukin-2 (IL-2), IL-4, IL-5, IL-6, tumor necrosis factor alpha (TNF-{alpha}), macrophage inflammatory protein-1-alpha (MIP-1-{alpha}) and leukemia inhibitory factor (LIF) in patients with prostate cancer. Methods and Materials: Forty eight patients with prostate cancer received three-dimensional conformal blocking radiation therapy with a linear accelerator. IL-2, IL-4, IL-5, IL-6, TNF-{alpha}, MIP-1-{alpha}, and LIF levels were measured by the related immunoassay kit 1 day before the beginning of RT and during RT at days 15 and 30. Results: The mean IL-2 values were elevated before and during the RT in contrast with those of IL-4, IL-5, IL-6, TNF-{alpha}, MIP-1-{alpha}, and LIF, which were within the normal range under the same conditions. Regarding markers IL-2, IL-4, IL-5, TNF-{alpha}, MIP-1-{alpha}, and LIF, comparisons among the three groups (before treatment and 15 and 30 days during RT) did not show significant differences. Although values were within the normal range, there was a significant rise in IL-6 levels at day 15 of RT (p = 0.0049) and a decline at day 30 to levels that were similar to those observed before RT. Conclusions: IL-6 appeared to peak after 15 days of RT before returning to pre-RT levels. In contrast, IL-2, IL-4, IL-5, TNF-{alpha}, MIP-1-{alpha}, and LIF levels were not sensitive to irradiation. The increased levels of IL-6 following RT without the concurrent elevation of other cytokines involved in the acute phase reaction did not suggest a classical inflammatory response to radiation exposure. Further studies should be designed to elucidate the role of IL-6 levels in patients with prostate cancer treated with RT.

  5. IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis.

    Science.gov (United States)

    Hong, Chien-Hui; Chang, Kee-Lung; Wang, Hung-Jen; Yu, Hsin-Su; Lee, Chih-Hung

    2015-06-01

    IL-9 and its receptor play important roles in the pathogenesis of asthma. Its role in atopic dermatitis (AD) was examined in just a few studies, including nucleotide polymorphisms, increased transcriptional levels of IL-9 and IL-9R in diseased skin, and an association of blood IL-9 levels with clinical severity. Little was known about the pathophysiological regulation of IL-9/IL-9R in AD skin. We asked whether IL-9R was expressed in epidermal keratinocytes; if so, what the functional outcome, cytokine production, and signaling pathway of IL-9/IL-9R in keratinocytes are. We measured and compared the expression of IL-9R in skin from AD patients and controls by immunofluorescence. We also performed in vitro studies on the IL-9-treated primary keratinocytes, including flow cytometry for IL-9R expressions, Western blotting for mTOR, S6K, ERK, p38, and STAT3 activations, ELISA for cytokine levels, and immunofluorescence for STIM1. We found that IL-9R was indeed expressed in keratinocytes but not in fibroblasts. Its expression in keratinocytes was enhanced by IL-4 but not by TGF-beta1. IL-9 induced a moderate production of IL-8 but not CXCL16, CCL22, TSLP, nor IL-33. IL-9 induced formation of STIM1-puncta. IL-9 induced ERK phosphorylation both dose- and time-dependently, but not mTOR, S6K, p38, or STAT3. Pretreatment with U0126 (ERK inhibitor) but not rapamycin (mTOR inhibitor) abrogated the IL-9-mediated IL-8 production. Blockage of STIM1 with BTP2 or SKF96265 abrogated ERK phosphorylation and IL-8 production induced by IL-9. This study represents the first to show the regulation of the IL-9-STIM1-ERK-IL-8 axis in keratinocyte, and how the axis might play an important role in the pathophysiology of AD. Copyright © 2015 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

  6. Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex

    Energy Technology Data Exchange (ETDEWEB)

    Logsdon, Naomi J.; Allen, Christopher E.; Rajashankar, Kanagalaghatta R.; Walter, Mark R. (Cornell); (UAB)

    2012-02-08

    Interleukin-20 (IL-20) is an IL-10-family cytokine that regulates innate and adaptive immunity in skin and other tissues. In addition to protecting the host from various external pathogens, dysregulated IL-20 signaling has been shown to contribute to the pathogenesis of human psoriasis. IL-20 signals through two cell-surface receptor heterodimers, IL-20R1-IL-20R2 and IL-22R1-IL-20R2. In this report, crystals of the IL-20-IL-20R1-IL-20R2 ternary complex have been grown from polyethylene glycol solutions. The crystals belonged to space group P4{sub 1}2{sub 1}2 or P4{sub 3}2{sub 1}2, with unit-cell parameters a = 111, c = 135 {angstrom}, and diffracted X-rays to 3 {angstrom} resolution. The crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%.

  7. Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice.

    Directory of Open Access Journals (Sweden)

    Carol L Murray

    Full Text Available Interleukin-1 (IL-1 is a key pro-inflammatory cytokine, produced predominantly by peripheral immune cells but also by glia and some neuronal populations within the brain. Its signalling is mediated via the binding of IL-1α or IL-1β to the interleukin-1 type one receptor (IL-1RI. IL-1 plays a key role in inflammation-induced sickness behaviour, resulting in depressed locomotor activity, decreased exploration, reduced food and water intake and acute cognitive deficits. Conversely, IL-1 has also been suggested to facilitate hippocampal-dependent learning and memory: IL-1RI(-/- mice have been reported to show deficits on tasks of visuospatial learning and memory. We sought to investigate whether there is a generalised hippocampal deficit in IL-1RI(-/- animals. Therefore, in the current study we compared wildtype (WT mice to IL-1RI(-/- mice using a variety of hippocampal-dependent learning and memory tasks, as well as tests of anxiety and locomotor activity. We found no difference in performance of the IL-1RI(-/- mice compared to WT mice in a T-maze working memory task. In addition, the IL-1RI(-/- mice showed normal learning in various spatial reference memory tasks including the Y-maze and Morris mater maze, although there was a subtle deficit in choice behaviour in a spatial discrimination, beacon watermaze task. IL-1RI(-/- mice also showed normal memory for visuospatial context in the contextual fear conditioning paradigm. In the open field, IL-1RI(-/- mice showed a significant increase in distance travelled and rearing behaviour compared to the WT mice and in the elevated plus-maze spent more time in the open arms than did the WT animals. The data suggest that, contrary to prior studies, IL-1RI(-/- mice are not robustly impaired on hippocampal-dependent memory and learning but do display open field hyperactivity and decreased anxiety compared to WT mice. The results argue for a careful evaluation of the roles of endogenous IL-1 in hippocampal

  8. A Brief History of IL-1 and IL-1 Ra in Rheumatology

    Directory of Open Access Journals (Sweden)

    Jean-Michel Dayer

    2017-05-01

    Full Text Available The history of what, in 1979, was called interleukin-1 (IL-1, orchestrator of leukocyte inter-communication, began many years before then, initially by the observation of fever induction via the endogenous pyrogen (EP (1974 and then in rheumatology on the role in tissue destruction in rheumatoid diseases via the induction of collagenase and PGE2 in human synovial cells by a mononuclear cell factor (MCF (1977. Since then, the family has exploded to presently 11 members as well as many membrane-bound and soluble receptor forms. The discovery of a natural Interleukin-1 receptor antagonist (IL-1Ra in human biological fluids has highlighted the importance of IL-1 and IL-1Ra in human diseases. Evidence delineating its role in autoinflammatory syndromes and the elucidation of the macromolecular complex referred to as “inflammasome” have been instrumental to our understanding of the link with IL-1. At present, the IL-1blockade as therapeutic approach is crucial for many hereditary autoinflammatory diseases, as well as for adult-onset Still’s disease, crystal-induced arthropathies, certain skin diseases including neutrophil-triggered skin diseases, Behçet’s disease and deficiency of IL-1Ra and other rare fever syndromes. Its role is only marginally important in rheumatoid arthritis and is still under debate with regard to osteoarthritis, type 2 diabetes mellitus, cardiovascular diseases and cancer. This brief historical review focuses on some aspects of IL-1, mainly IL-1β and IL-Ra, in rheumatology. There are many excellent reviews focusing on the IL-1 family in general or with regard to specific diseases or biological discoveries.

  9. Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer

    Science.gov (United States)

    Richter, Cornelia; Herrero San Juan, Martina; Weigmann, Benno; Bergis, Dominik; Dauber, Katrin; Muders, Michael H.; Baretton, Gustavo B.; Pfeilschifter, Josef Martin; Bonig, Halvard; Brenner, Sebastian; Radeke, Heinfried H.

    2017-01-01

    In the colon, a sophisticated balance between immune reaction and tolerance is absolutely required. Dysfunction may lead to pathologic phenotypes ranging from chronic inflammatory processes to cancer development. Two prominent modulators of colon inflammation are represented by the closely related cytokines interleukin (IL)-12 and IL-23, which initiate adaptive Th1 and Th17 immune responses, respectively. In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model. Initially, we found that IL-12−/− mice developed less severe colitis but are highly susceptible to colon cancer. By contrast, p47phox−/− mice showed lower tumor scores and fewer high grade tumors than wild-type (WT) littermates. Treatment with toll-like receptor 9 ligand CpG2216 significantly enhanced colitis in p47phox−/− mice, whereas tumor growth was simultaneously reduced. In tumor tissue of p47phox−/− mice, the IL-23/IL-17 axis was crucially hampered. IL-23p19 protein expression in tumor tissue correlated with tumor stage. Reconstitution of WT mice with IL-23p19−/− bone marrow protected these mice from colon cancer, whereas transplantation of WT hematopoiesis into IL-23p19−/− mice increased the susceptibility to tumor growth. Our study strengthens the divergent role of IL-12 and IL-23 in colon cancer development. With the characterization of p47phox as a novel modulator of both cytokines our investigation introduces a promising new target for antitumor strategies. PMID:28191009

  10. Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections.

    Science.gov (United States)

    Stappers, M H T; Thys, Y; Oosting, M; Plantinga, T S; Ioana, M; Reimnitz, P; Mouton, J W; Netea, M G; Joosten, L A B; Gyssens, I C

    2014-12-01

    Complicated skin and skin structure infections (cSSSIs) are caused by Gram-positive and Gram-negative, aerobic and anaerobic pathogens, with a polymicrobial aetiology being frequent. Recognition of invading pathogens by the immune system results in the production of pro- and anti-inflammatory cytokines, which are extremely important for intercellular communication and control of infection. This study assessed whether genetic variation in genes encoding cytokines influences the susceptibility to cSSSIs. For the association study, 318 patients with cSSSI and 328 healthy controls were genotyped for single nucleotide polymorphisms (SNPs) in cytokine genes IL1A, IL1B, IL1RN, TNF, IL10, IL17A, IL17F and IFNG. For immunological validation, peripheral blood mononuclear cells (PBMCs) from 74 healthy individuals, genotyped for SNPs of interest, were stimulated with Staphylococcus aureus or Escherichia coli and corresponding cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA). Polymorphisms IL6 rs1800797, TNF rs1800629, IL10 rs1800871, IL17A rs8193036 and IFNG rs2069705 influenced susceptibility to cSSSIs. No differences in cytokine responses, stratified for genotype, were detected after PBMC stimulation. No association with cSSSIs was observed for polymorphisms IL1A rs17561 and rs1800587, IL1B rs16944 and rs1143627, IL1RN rs4251961, TNF rs361525, IL10 rs1800896, IL17A rs2275913 and IL17F rs763780. In conclusion, polymorphisms in IL6, TNF, IL10, IL17A and IFNG are associated with susceptibility to cSSSIs.

  11. ASSOCIATION OF IL-1β, IL-4 AND IL-6 GENES POLYMORPHISMS WITH GENETIC PREDISPOSITION FOR AUTOIMMUNE THYROIDITIS

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    E. M. Biktagirova

    2011-01-01

    Full Text Available Abstract.  Autoimmune  thyroiditis  (Hashimoto’s  thyroiditis,  HT  still  represents  an  unresolved  problem of modern endocrinology, since its etiology and pathogenesis are yet unclear. Cytokines play an important role in the regulation of immune and inflammatory response, therefore, some gene variants encoding them, are considered as potential risk risk factors for autoimmune thyroid diseases. We have genotyped 298 women from the Republic of Tatarstan (RT, control group, 137 persons; HT patients, 161 for the following gene polymorphisms: interleukin-1 beta (IL-1β +3953 C/T (rs 1143634; interleukin 4 (IL-4 -590C/T (rs 2243250, and interleukin 6 (IL-6 -174C/G (rs 1800795, using allele-specific PCR. The results showed a significantly increased frequencies of C allele (P  = 0.0003 and CT genotype (P  = 0.048, OR  = 6.05, 95%CI 2.59-2.97 of  +3953  C/T  of  IL-1β  in  patients  with  Hashimoto's thyroiditis, as compared with control group. The latter  group showed higher prevalence of T allele (P  = 0.0003 and TT genotype (P  = 4.95 Ч 6.10; OR  = 0.15, 95%CI 0.06-0.38. The 590C/T and -174C/G polymorphic variants in, resp., IL-4 and IL-6 genes are not associated with increased risk of this disease among women from RT. (Med. Immunol., 2011, vol. 13, N 6, pp 603-608 

  12. Los bienes de interés cultural de Gáldar (Canarias y el conjunto histórico “Plaza de Santiago” (1981-2006

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    Juan Sebastián López García

    2013-10-01

    Full Text Available En 1981, hace veinticinco años, la zona central de Gáldar fue declarada “Conjunto Histórico Artístico” con la denominación de Plaza de Santiago. Sin embargo no era el primer bien cultural que obtenía una distinción de este tipo, ya que Gáldar había sido pionera en 1949 con el yacimiento de El Agujero y La Guancha, primero de los de carácter arqueológico declarado en Canarias, al que seguiría en 1972 la Cueva Pintada. Hasta la década de los setenta prevalecieron los bienes arqueológicos, situación que se modificó en las dos últimas décadas del siglo XX después del reconocimiento de la Plaza de Santiago y su entorno. Junto con edificaciones religiosas también se incluyeron ejemplos de arquitectura doméstica, completándose con algunos yacimientos prehispánicos. Una particular circunstancia fue la declaración en 1993 del pago de Barranco Hondo de Abajo, lo que convertía a Gáldar en el primer municipio de Canarias que contaba con dos conjuntos históricos, siendo éste a la vez el primero de la comunidad autonóma con características rurales. De la relación de los declarados, si exceptuamos la mayoría de los de carácter arqueológico, buena parte son urbanos. Una característica es que se incluyen categorías variadas, incluyendo la existencia de una zona arqueológica junto a un conjunto histórico y varios monumentos (de arquitectura religiosa y doméstica. Este hecho es lógico si se tiene en cuenta la particularidad de Gáldar y su condición de núcleo histórico de superposición.Twenty five years ago, in 1981, the central zone of Galdar was declared an "Historic Artistic Site" with the name of Plaza de Santiago. But this was not the first cultural asset to obtain a distinction of this kind, as Galdar pioneered protection of this kind with the El Agujero and La Guancha site, the first archaeological site declared in the Canary Islands, followed by La Cueva Pintada, in 1972. Archaeological assets prevailed up

  13. Construction of an expression system for bioactive IL-18 and generation of recombinant canine distemper virus expressing IL-18.

    Science.gov (United States)

    Liu, Yuxiu; Sato, Hiroki; Hamana, Masahiro; Moonan, Navita Anisia; Yoneda, Misako; Xia, Xianzhu; Kai, Chieko

    2014-09-01

    Interleukin 18 (IL-18) plays an important role in the T-helper-cell type 1 immune response against intracellular parasites, bacteria and viral infections. It has been widely used as an adjuvant for vaccines and as an anticancer agent. However, IL-18 protein lacks a typical signal sequence and requires cleavage into its mature active form by caspase 1. In this study, we constructed mammalian expression vectors carrying cDNA encoding mature canine IL-18 (cIL-18) or mouse IL-18 (mIL-18) fused to the human IL-2 (hIL-2) signal sequence. The expressed proIL-18 proteins were processed to their mature forms in the cells. The supernatants of cells transfected with these plasmids induced high interferon-γ production in canine peripheral blood mononuclear cells or mouse splenocytes, respectively, indicating the secretion of bioactive IL-18. Using reverse genetics, we also generated a recombinant canine distemper virus that expresses cIL-18 or mIL-18 fused to the hIL-2 signal sequence. As expected, both recombinant viruses produced mature IL-18 in the infected cells, which secreted bioactive IL-18. These results indicate that the signal sequence from hIL-2 is suitable for the secretion of mature IL-18. These recombinant viruses can also potentially be used as immunoadjuvants and agents for anticancer therapies in vivo.

  14. IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex

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    Tae Sik Goh

    2017-01-01

    Full Text Available IL-7 signaling via IL-7Rα and common γ-chain (γc is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7Rα downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-7Rα and γc in the absence or presence of IL-7 remains unclear. Additionally, we are still uncertain as to how only IL-7Rα is separately downregulated by the binding of IL-7 from the IL-7Rα/γc complex. We demonstrate here that 4G3, TUGm2, and 3E12 epitope masking of γc protein are induced in the presence of IL-7, indicating that the epitope alteration is induced by IL-7 binding to the preassembled receptor core. Moreover, the epitope masking of γc protein is inversely correlated with the expression of IL-7Rα upon IL-7 binding, implying that the structural alteration of γc might be involved in the regulation of IL-7Rα expression. The conformational change in γc upon IL-7 binding may contribute not only to forming the functional IL-7 signaling complex but also to optimally regulating the expression of IL-7Rα.

  15. Components of the RANK/RANKL/OPG system, IL-6, IL-8, IL-16, MMP-2, and calcitonin in the sera of patients with bone tumors.

    Science.gov (United States)

    Kushlinskii, N E; Timofeev, Yu S; Solov'ev, Yu N; Gerstein, E S; Lyubimova, N V; Bulycheva, I V

    2014-08-01

    Serum levels of sRANKL, RANK, OPG, IL-8, IL-6, IL-16, MMP-2, and calcitonin were measured by ELISA in patients with malignant, borderline, and benign bone tumors and in healthy individuals (control). Serum levels of RANK, OPG, IL-8, IL-6, and the OPG/sRANKL ratio were significantly higher, while the level of MMP-2 was significantly lower in patients with bone tumors than in controls. Serum concentration of IL-16 in osteosarcoma patients was significantly lower than in chondrosarcoma patients. No significant differences between bone sarcomas of different differentiation were detected for any of the studied markers. Calcitonin level depended on the tumor location and type.

  16. IL-17、IL-8、IL-10水平与早期糖尿病肾病的关系

    Institute of Scientific and Technical Information of China (English)

    王卫娜

    2016-01-01

    目的 观察糖尿病大鼠肾脏早期IL-17、IL-8、IL-10水平的变化,并分析糖尿病大鼠肾脏早期IL-17、IL-8、IL-10水平与糖尿病肾病的关系.方法 健康雄性SD大鼠被随机分为正常对照组和糖尿病模型组,模型组以一次性腹腔注射STZ诱导糖尿病模型;造模成功后在1周、2周、4周、6周,12周时间点分别取两肾,称量两肾的重量及大鼠体重,常规方法检测血清生化指标和尿蛋白含量,ELISA检测IL-17、IL-8、IL-10水平.分析IL-17、IL-8、IL-10水平与糖尿病肾病的关系.结果糖尿病各组大鼠IL-17、IL-8随时间逐渐升高,IL-10随时间逐渐降低,IL-17、IL-8与血糖、CRP、肾脏肥大指数、24小时尿蛋白、肌酐、血尿素氮呈正相关,IL-10与血糖、CRP、肾脏肥大指数、24小时尿蛋白、肌酐、血尿素氮呈负相关,IL-17、IL-8与IL-10呈负相关.结论IL-17、IL-8可能促进糖尿病大鼠肾病的发展,IL-10可能抑制糖尿病大鼠肾病的进展.

  17. La evolución de las exportaciones de bienes de China: una visión panarómica = Chinese goods exports development: An overview

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    Ana Salvador Chamorro

    2013-12-01

    Full Text Available El proceso de reforma económica que ha experimentado la economía de China es uno de los fenómenos de mayor relevancia en la evolución de la Economía Mundial en los últimos treinta años y, sin duda, seguirá siéndolo en el futuro. Dentro de este proceso, la apertura al exterior, que el gobierno chino inició en 1978, ha situado al país en un lugar de máxima relevancia dentro de los flujos comerciales y financieros internacionales. En este contexto, el objetivo de este trabajo es intentar realizar un análisis general de la evolución del comercio exterior de China en las últimas décadas, prestando especial atención a sus exportaciones de bienes y poniendo énfasis en los cambios experimentados durante los últimos años.The process of economic reform that has experienced the Chinese economy is one of the most important events in the evolution of the World Economy in the past 30 years, and will undoubtedly remain so in the future. Within this economic reform, the opening process that the Chinese Government began in 1978, has put the country in a place of utmost importance in the international trade and financial flows. In this context, this paper try to perform an analysis of the evolution of China's foreign trade in recent decades, with particular attention to its exports and emphasizing the changes in recent years

  18. La evolución de las exportaciones de bienes de China: una visión panarómica = Chinese goods exports development: An overview

    Directory of Open Access Journals (Sweden)

    Ana Salvador Chamorro

    2014-07-01

    Full Text Available Resumen El proceso de reforma económica que ha experimentado la economía de China es uno de los fenómenos de mayor relevancia en la evolución de la Economía Mundial en los últimos treinta años y, sin duda, seguirá siéndolo en el futuro. Dentro de este proceso, la apertura al exterior, que el gobierno chino inició en 1978, ha situado al país en un lugar de máxima relevancia dentro de los flujos comerciales y financieros internacionales. En este contexto, el objetivo de este trabajo es intentar realizar un análisis general de la evolución del comercio exterior de China en las últimas décadas, prestando especial atención a sus exportaciones de bienes y poniendo énfasis en los cambios experimentados durante los últimos años. Abstract The process of economic reform that has experienced the Chinese economy is one of the most important events in the evolution of the World Economy in the past 30 years, and will undoubtedly remain so in the future. Within this economic reform, the opening process that the Chinese Government began in 1978, has put the country in a place of utmost importance in the international trade and financial flows. In this context, this paper try to perform an analysis of the evolution of China's foreign trade in recent decades, with particular attention to its exports and emphasizing the changes in recent years.

  19. EL BESTIARIO DEL HISTORIADOR: LAS BIOGRAFÍAS DE "MONSTRUOS" DE BENJAMÍN VICUÑA MACKENNA Y LA IDENTIDAD LIBERAL COMO UN BIEN EN DISPUTA

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    Manuel Vicuña

    2008-06-01

    Full Text Available Este trabajo identifica y analiza una conjunto heterogéneo de textos (libros, artículos de prensa, folletos, diarios personales del historiador Benjamín Vicuña Mackenna, los cuales, si bien aluden a temáticas muy diversas, conforman una constelación de sentido marcada por el esfuerzo de apropiación de la identidad liberal, definida no en función de las disputas ideológicas con la Iglesia Católica y el Partido Conservador, sino con relación a la lucha por la libertad electoral y el ensanchamiento de la base de ejercicio de la soberanía popular, cualquiera fuera el signo político del gobierno en ejercicio. Para ello, indaga en obras de distintos periodos del historiador, así como en variados episodios de su biografía, con el propósito de contextualizar las circunstancias de producción de los textos de interés para el análisis.This article identifies and analyzes a heterogeneous body of texts (books, press articles, pamphlets and personal diaries authored by Chilean historian Benjamín Vicuña Mackenna. These texts form part of a single constellation of meaning characterized by the effort of appropriation of a liberal identity, although they concern different subjects and were intended for diverse readerships. This identity was not defined based on the disputes with the Catholic Church or by the Conservative Party. Instead identity was defined by taking into account the fight for electoral freedom and the democratizing effects of popular sovereignty. The article explores the works of Vicuña Mackenna and various episodes of his life to contextualize the circumstances of the texts analyzed.

  20. Composición de los hogares y niveles de gastos en bienes y servicios básicos en el departamento del cauca, Colombia

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    Andrés Mauricio Gómez Sánchez

    2016-03-01

    Full Text Available Éste documento tiene como objetivo caracterizar los hogares rurales y urbanos del departamento del Cauca, Colombia y clasificarlos según la tipología y el ciclo de vida del hogar, para establecer su relación con los niveles de gasto mínimo en bienes básicos, es decir, con los que definen los umbrales críticos de pobreza. Para tal efecto, se utiliza la Encuesta de Calidad de Vida de 2011 y se estiman modelos de análisis de varianza multifactoriales. Los resultados muestran, entre otros, que el tipo de hogar más frecuente, tanto en el área rural como la urbana, es el nuclear con hijos y los gastos mínimos básicos, en general, son en alimentos, vivienda y salud. Los rubros de educación y transporte presentan niveles más altos de consumo en los hogares urbanos que en los rurales. The main objective of this paper is to describe the rural and urban households of the Cauca department in Colombia. The idea is to classify the households according to their typology and household life cycle in order to establish their relation with the minimum levels of expenditure on basic goods, this means with the ones that define the critical poverty thresholds. For this end, the 2011 Quality of Life survey is used as well as multifactorial variance analysis. The results show that the most common type of household for both rural and urban areas is the nuclear type of household with children, showing usually a minimal basic expenditure on food, housing and health. Education and transportation present higher consump-tion levels at urban households.