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Sample records for construction sixth edition

  1. Content Area Literacy: An Integrated Approach. Sixth Edition.

    Science.gov (United States)

    Readence, John E.; Bean, Thomas W.; Baldwin, R. Scott

    The sixth edition of this book presents preservice and inservice teachers with theory and related teaching strategies designed to assist middle and secondary students in reading and learning from their textbooks, and this edition seeks to integrate the current state of the art with some personal ideas. It includes a CD-ROM Digital Supplement which…

  2. Book Review: Game Ranch Management (Sixth Edition) | Peel ...

    African Journals Online (AJOL)

    Book Title: Game Ranch Management (Sixth Edition). Book Authors: J du P Bothma & J.G. du Toit (Eds.) 2016, Van Schaik Publishers, PO Box 12681, Hatfield 0028, Pretoria, South Africa 1012 pages, hardcover, eBook and ePub. ISBN: 9780627033469, 9780627033476 (eBook), 9780627034909 (ePub). Price R949.00 ...

  3. Foundations of Bilingual Education and Bilingualism. Sixth Edition

    Science.gov (United States)

    Baker, Colin; Wright, Wayne E.

    2017-01-01

    The sixth edition of this bestselling textbook has been substantially revised and updated to provide a comprehensive introduction to bilingualism and bilingual education in the 21st century. Written in a compact and clear style, the book covers all the crucial issues in bilingualism at individual, group and societal levels. Updates to the new…

  4. Molecular Biology of the Cell, Sixth Edition; ISBN: 9780815344643; and Molecular Biology of the Cell, Sixth Edition, The Problems Book; ISBN 9780815344537

    Directory of Open Access Journals (Sweden)

    Stephen Bustin

    2015-11-01

    Full Text Available The latest edition maintains the excellence and appeal of the previous editions. Its clear text and outstanding illustrations, together with the complementary problems book make this an essential companion for students and lecturers alike.

  5. Raising voices: How sixth graders construct authority and knowledge in argumentative essays

    Science.gov (United States)

    Monahan, Mary Elizabeth

    This qualitative classroom-based study documents one teacher-researcher's response to the "voice" debate in composition studies and to the opposing views expressed by Elbow and Bartholomae. The author uses Bakhtin's principle of dialogism, Hymes's theory of communicative competence, as well as Ivanic's discussion of discoursally constructed identities to reconceptualize voice and to redesign writing instruction in her sixth grade classroom. This study shows how students, by redefining and then acting on that voice pedagogy in terms that made sense to them, shaped the author's understanding of what counts as "voiced" writing in non-narrative discourse. Based on a grounded-theory analysis of the twenty-six sixth graders' argumentative essays in science, the author explains voice, not as a property of writers or of texts, but as a process of "knowing together"---a collaborative, but not entirely congenial, exercise of establishing one's authority by talking with, against, and through other voices on the issue. As the results of this study show, the students' "I-Ness" or authorial presence within their texts, was born in a nexus of relationships with "rivals," "allies" and "readers." Given their teacher's injunctions to project confidence and authority in argumentative writing, the students assumed fairly adversarial stances toward these conversational partners throughout their essays. Exaggerating the terms for voiced writing built into the curriculum, the sixth graders produced essays that read more like caricatures than examples of argumentation. Their displays of rhetorical bravado and intellectual aggressiveness, however offsetting to the reader, still enabled these sixth graders to composed voiced essays. This study raises doubts about the value of urging students to sound like their "true selves" or to adopt the formal registers of academe. Students, it seems clear, stand to gain by experimenting with a range of textual identities. The author suggests that voice

  6. Constructs and methods for genome editing and genetic engineering of fungi and protists

    Science.gov (United States)

    Hittinger, Christopher Todd; Alexander, William Gerald

    2018-01-30

    Provided herein are constructs for genome editing or genetic engineering in fungi or protists, methods of using the constructs and media for use in selecting cells. The construct include a polynucleotide encoding a thymidine kinase operably connected to a promoter, suitably a constitutive promoter; a polynucleotide encoding an endonuclease operably connected to an inducible promoter; and a recognition site for the endonuclease. The constructs may also include selectable markers for use in selecting recombinations.

  7. Sixth form pure mathematics

    CERN Document Server

    Plumpton, C

    1968-01-01

    Sixth Form Pure Mathematics, Volume 1, Second Edition, is the first of a series of volumes on Pure Mathematics and Theoretical Mechanics for Sixth Form students whose aim is entrance into British and Commonwealth Universities or Technical Colleges. A knowledge of Pure Mathematics up to G.C.E. O-level is assumed and the subject is developed by a concentric treatment in which each new topic is used to illustrate ideas already treated. The major topics of Algebra, Calculus, Coordinate Geometry, and Trigonometry are developed together. This volume covers most of the Pure Mathematics required for t

  8. Electric utility power plant construction costs, 1st Edition

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    New UDI report combines historical construction costs for more than 1,000 coal, oil, gas, nuclear and geothermal units that have entered commercial operation since 1966 and projected power plant construction costs for about 400 utility-owned generating units scheduled to enter commercial operation during the next 20 years. Key design characteristics and equipment suppliers, A/E, constructor and original installed cost data. Direct construction costs without AFUDC are provided where known. Historical construction cost data are also provided for about 130 utility-owned hydroelectric, gas turbine, combined-cycle and diesel units (these data are generally for units entering service after 1980)

  9. Introduction to Drywall. Instructor Edition. Introduction to Construction Series.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This instructor's guide contains the materials required to teach a competency-based introductory course in drywalling to students who have chosen to explore careers in construction. It contains three units: drywall materials, drywall tools, and applied skills. Each instructional unit includes some or all of the basic components of a unit of…

  10. Introduction to Drywall. Introduction to Construction Series. Instructor Edition.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This competency-based curriculum guide on the specialty area of drywall is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs in mind.…

  11. Introduction to Concrete Masonry. Introduction to Construction Series. Instructor Edition.

    Science.gov (United States)

    Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

    This competency-based curriculum guide on the specialty area of concrete masonry is part of the Introduction to Construction series. The series is designed with the flexible training requirements of open shop contractors, preapprenticeship programs, multicraft high school programs, technology education programs, and cooperative education programs…

  12. The relation between children's constructive play activities, spatial ability, and mathematical word problem-solving performance: a mediation analysis in sixth-grade students.

    Science.gov (United States)

    Oostermeijer, Meike; Boonen, Anton J H; Jolles, Jelle

    2014-01-01

    The scientific literature shows that constructive play activities are positively related to children's spatial ability. Likewise, a close positive relation is found between spatial ability and mathematical word problem-solving performances. The relation between children's constructive play and their performance on mathematical word problems is, however, not reported yet. The aim of the present study was to investigate whether spatial ability acted as a mediator in the relation between constructive play and mathematical word problem-solving performance in 128 sixth-grade elementary school children. This mediating role of spatial ability was tested by utilizing the current mediation approaches suggested by Preacher and Hayes (2008). Results showed that 38.16% of the variance in mathematical word problem-solving performance is explained by children's constructive play activities and spatial ability. More specifically, spatial ability acted as a partial mediator, explaining 31.58% of the relation between constructive play and mathematical word problem-solving performance.

  13. The Revista SCIENTIFIC of the Instituto Internacional de Investigación y Desarrollo Tecnológico Educativo (INDTEC, C.A., presents its sixth edition

    Directory of Open Access Journals (Sweden)

    Carina Viviana Ganuza

    2017-11-01

    Full Text Available The Revista Scientific of the Instituto Internacional de Investigación y Desarrollo Tecnológico Educativo (INDTEC, C.A., presents its sixth editorial edition where fifteen works can be found in response to the search for interest in the investigation, analysis and interpretation of different topics. In this way, in a first section, the educational axes constituted in questions of questions respond to: the Teacher Training in Techniques applied to the Teaching of Mathematics in Secondary Education; Reading Alternatives considered for the Strengthening of Educational Quality; Advertising Effectiveness for Road Safety; Ecuadorian Education in English and their language skills in rural students; Didactic Strategies to improve Reading and Writing; the Importance of the Planning of the Environmental Education in the University Scope considered from a Transdisciplinary Perspective; the Utility of Tics in the Training of University Teaching Advisors; the Complementary Didactic Material for the Learning of Rational Mechanical Curriculum Unit 10 and the Tutor Role in the context of virtual learning. In continuity, other articles stand out, such as the Environmental Actions for the Conservation of Hydrographic Basins; the application of the Educaplay Computer Technique as a strategy for the learning of biomolecules in high school students of the Andrés F. Córdova Educational Unit; Program for Parents in the Internet use of their children; Bamboo Cultivation considered a renewable natural resource for reforestation in Quebrada Echeverría and corporate social responsibility in the context of labor relations in SMEs. In a second section, five essays induce us to reflect on perspectives of analysis in response to: Technological Imbrications in Pedagogical Praxis; Advanced Management in the Process of University Scientific Research; the Training in Citizen Culture Space and its importance for the Social Responsibility of Business Organizations; the

  14. Comparison of Wechsler Memory Scale-Fourth Edition (WMS-IV) and Third Edition (WMS-III) dimensional structures: improved ability to evaluate auditory and visual constructs.

    Science.gov (United States)

    Hoelzle, James B; Nelson, Nathaniel W; Smith, Clifford A

    2011-03-01

    Dimensional structures underlying the Wechsler Memory Scale-Fourth Edition (WMS-IV) and Wechsler Memory Scale-Third Edition (WMS-III) were compared to determine whether the revised measure has a more coherent and clinically relevant factor structure. Principal component analyses were conducted in normative samples reported in the respective technical manuals. Empirically supported procedures guided retention of dimensions. An invariant two-dimensional WMS-IV structure reflecting constructs of auditory learning/memory and visual attention/memory (C1 = .97; C2 = .96) is more theoretically coherent than the replicable, heterogeneous WMS-III dimension (C1 = .97). This research suggests that the WMS-IV may have greater utility in identifying lateralized memory dysfunction.

  15. Theoretical mechanics for sixth forms

    CERN Document Server

    Plumpton, C

    1971-01-01

    Theoretical Mechanics for Sixth Forms, Second Edition is a 14-chapter book that begins by elucidating the nature of theoretical mechanics. The book then describes the statics of a particle in illustration of the techniques of handling vector quantities. Subsequent chapters focus on the principle of moments, parallel forces and centers of gravity; and the application of Newton's second law to the dynamics of a particle and the ideas of work and energy, impulse and momentum, and power. The concept of friction is also explained. This volume concludes with chapters concerning motion in a circle an

  16. Energy saving monitor of the built environment. U-construction panel. Results of the sixth measurement 2008; Energiebesparingsmonitor gebouwde omgeving. U-bouwpanel. Resultaten zesde meting 2008

    Energy Technology Data Exchange (ETDEWEB)

    Hoevenagel, R.; Brammer, K. [Stratus Technologies, Badhoevedorp (Netherlands)

    2009-08-15

    Having accurate and reliable information about energy saving measures and the energy use in the built environment is essential for developing effective CO2 reduction policy for this target group as well as for implementation, adjusting (if needed) and for evaluation. To this end, the Energy Saving Monitor Built Environment (EBM) was established. This monitor has two target groups: house-building and commercial and industrial building. The annual measuring focuses on questions about the energy saving measures that have been taken (with regard to insulation, lighting, heating, cooling and renewable energy) and the energy use. In addition, the most recent measurements increasingly raise questions that follow from the collection of information for the Energy Performance of Buildings Directive, which is the European Directive for energy performance in buildings. This report provides the results of the sixth measurement of the U-construction panel. This measurement was conducted in the period May-June 2008 among 1,044 representatives of commercial and industrial buildings in the Netherlands. [Dutch] Het beschikbaar hebben van nauwkeurige en betrouwbare informatie over de genomen energiebesparende maatregelen, en van het energieverbruik in de gebouwde omgeving is essentieel om voor deze doelgroep een effectief CO2-reductiebeleid te kunnen ontwikkelen, te implementeren, zo nodig bij te sturen en te evalueren. Hiertoe is de zogenaamde Energiebesparingsmonitor gebouwde omgeving (EBM) opgezet. Deze monitor omvat twee doelgroepen: de woningbouw en de utiliteitsbouw. In de jaarlijkse metingen staan vragen over de genomen energiebesparende maatregelen (op het gebied van isolatie, verlichting, verwarming, koeling en duurzame energie) en het energieverbruik centraal. Hiernaast worden in de laatste metingen in toenemende mate vragen gesteld die voortvloeien uit het verzamelen van informatie ten behoeve van de Energy Performance Building Directive, de Europese richtlijn voor

  17. Transportation Energy Data Book. Sixth edition

    Energy Technology Data Exchange (ETDEWEB)

    Kulp, G.; Holcomb, M. C.

    1982-01-01

    Designed for use as a desk-top reference, the data book represents an assembly and display of statistics that characterize transportation activity and presents data on other factors that influence transportation energy use. The purpose of this publication is to present a large amount of relevant data in an easily retrievable and usable format with the statistical data shown in the form of tables and graphs. Each of the major transportation modes (highway, air, water, rail, and pipeline) is treated separately, and aggregate energy use and energy supply data for all modes are presented. The highway mode, accounting for over 77% of total transportation energy consumption, is dealt with. Topics in this include vehicle stock characteristics, fuel efficiency, household vehicle ownership and use, fleet automobiles, buses, and trucks. Data are presented on each of the nonhighway modes: air, water, pipeline, and rail, respectively. Trends in vehicle and engine characteristics related to fuel economy are summarized. Emphasis is placed on vehicles and engines for highway use.

  18. Leadership: Theory and Practice. Sixth Edition

    Science.gov (United States)

    Northouse, Peter G.

    2012-01-01

    Adopted at more than 1,000 colleges and universities worldwide, the market-leading text owes its success to the unique way in which it combines an academically robust account of the major theories and models of leadership with an accessible style and practical exercises that help students apply what they learn. Each chapter of Peter…

  19. Validity aspects of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, narcissistic personality disorder construct.

    Science.gov (United States)

    Karterud, Sigmund; Øien, Maria; Pedersen, Geir

    2011-01-01

    The Diagnostic and Statistical Manual of Mental Disorders (DSM), Fourth Edition, narcissistic personality disorder (NPD) construct has been criticized for being too narrowly defined, for example, by focusing on overt grandiosity at the expense of exhibitionism and narcissistic vulnerability and thus covering only parts of the domain of narcissism. The purpose of this study was to elucidate several validity aspects of the NPD construct. The material consisted of data from 2277 patients (80% of whom had a personality disorder [PD]) who were admitted to units connected to The Norwegian Network of Psychotherapeutic Day Hospitals. The Axis II diagnoses were assessed by Structured Clinical Interview for DSM, Fourth Edition, Axis II Personality Disorders. The frequency of NPD was very low (0.8%). Male patients were overrepresented both on a diagnostic level and on criteria levels. The NPD category was positively associated with other cluster B disorders and negatively associated with avoidant PD. The criteria "demands excessive admiration" and "fantasies of unlimited success" correlated almost as highly with the histrionic PD category and loaded primarily on a histrionic factor. The dominant NPD factor also included the antisocial criterion of "showing no regret having injured others." The major part of the patients' personality pathology could be attributed to other PD criteria. The results challenge the notion of NPD as a distinct diagnostic category. Rather, narcissism should be conceived as personality dimensions pertinent to the whole range of PDs. The results support the views put forward by Russ et al (Refining the construct of narcissistic personality disorder: diagnostic criteria and subtypes. Am J Psychiatry 2008;11:1473-1481) that what clinicians conceive as narcissism consists of several subtypes (dimensions). Our data support the existence of a grandiose/malignant type and an exhibitionistic type. Unfortunately, there was no measure of hypersensitivity. The

  20. On the further development of the electronic edition «NANOTECHNOLOGIES IN CONSTRUCTION: A Scientific Internet-Journal» in 2015

    Directory of Open Access Journals (Sweden)

    GUSEV Boris Vladimirovich

    2015-12-01

    Full Text Available In 2015 the electronic edition «NANOTECHNOLOGIES IN CONSTRUCTION: A Scientific Internet-Journal» achieved a great success, it is recognized not only by Russian scientists but also foreign ones: • the geography of the edition’s authors has been enlarged, the new sections and columns have been introduced; • the edition has been included in the following citation systems (data bases: Global Impact Factor (Australia, EZB (Germany, ResearchGate (USA, DOAJ (Sweden; • the edition has been included in the list of peer-review journals in which the candidates for Ph.D. and Doctorate degree must publish the main results of their theses; • the edition provided information support for the largest events in the area of construction and nanoindustry (BATIMAT, IV International congress of the nanoindustrial enterprises, SIBBUILD et al..

  1. [Application of CRISPR-Cas9 genome editing for constructing animal models of human diseases].

    Science.gov (United States)

    Ou, Zhanhui; Sun, Xiaofang

    2016-08-01

    The CRISPR-Cas9 system is a new targeted nuclease for genome editing, which can directly introduce modifications at the targeted genomic locus. The system utilizes a short single guide RNA (sgRNA) to direct the endonuclease Cas9 in the genome. Upon targeting, Cas9 can generate DNA double-strand breaks (DSBs). As such DSBs are repaired by non-homologous end joining (NHEJ) or homology directed repair (HDR), therefore facilitates introduction of random or specific mutations, repair of endogenous mutations, or insertion of DNA elements. The system has been successfully used to generate gene targeted cell lines including those of human, animals and plants. This article reviews recent advances made in this rapidly evolving technique for the generation of animal models for human diseases.

  2. General design, construction, and operation guidelines: Constructed wetlands wastewater treatment systems for small users including individual residences. Second edition

    Energy Technology Data Exchange (ETDEWEB)

    Steiner, G.R.; Watson, J.T.

    1993-05-01

    One of the Tennessee Valley Authority`s (TVA`s) major goals is cleanup and protection of the waters of the Tennessee River system. Although great strides have been made, point source and nonpoint source pollution still affect the surface water and groundwater quality in the Tennessee Valley and nationally. Causes of this pollution are poorly operating wastewater treatment systems or the lack of them. Practical solutions are needed, and there is great interest and desire to abate water pollution with effective, simple, reliable and affordable wastewater treatment processes. In recognition of this need, TVA began demonstration of the constructed wetlands technology in 1986 as an alternative to conventional, mechanical processes, especially for small communities. Constructed wetlands can be downsized from municipal systems to small systems, such as for schools, camps and even individual homes.

  3. Is the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, histrionic personality disorder category a valid construct?

    Science.gov (United States)

    Bakkevig, Jonas F; Karterud, Sigmund

    2010-01-01

    The study investigated crucial aspects of the construct validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) histrionic personality disorder (HPD) category. The study included 2289 patients from the Norwegian Network of Psychotherapeutic Day Hospitals. Construct validity was assessed by means of prevalence, comorbidity with other personality disorders, internal consistency among HPD criteria, severity indices, as well as factor analyses. The prevalence of HPD was very low (0.4 %). The comorbidity was high, especially with borderline, narcissistic, and dependent personality disorders. The internal consistency was low. The criteria seemed to form 2 separate clusters: the first contained exhibitionistic and attention-seeking traits and the other contained impressionistic traits. The results indicated poor construct validity of the HPD category. Different options for the future of the category are discussed. The authors suggest the HPD category to be deleted from the DSM system. However, the clinical phenomena of exhibitionism and attention-seeking, which are the dominant personality features of HPD, should be preserved in an exhibitionistic subtype of narcissism. Copyright 2010 Elsevier Inc. All rights reserved.

  4. The relation between early constructive play and mathematical word problem solving is mediated by spatial ability. A path analysis in sixth grade students.

    NARCIS (Netherlands)

    Oostermeijer, M.; Boonen, A.J.H.; Jolles, J.

    2014-01-01

    The scientific literature shows that constructive play activities are positively related to children's spatial ability. Likewise, a close positive relation is found between spatial ability and mathematical word problem-solving performances. The relation between children's constructive play and their

  5. THE SPRINGBOK SIXTH DIVISION

    African Journals Online (AJOL)

    The Springboks showed the enemy that they were on the ball. On Lordly Mont' Sorrate they trained their ... From peak to peak in front of them the message was relayed. By the Reichsfuehrer Division, the SS corps d' ... Between the Sixth Div front line and the German rock-bound lair. Lay a sinister stretch of no-man's land of ...

  6. Unilateral sixth nerve palsy.

    Science.gov (United States)

    Sotoodehnia, Mehran; Safaei, Arash; Rasooli, Fatemeh; Bahreini, Maryam

    2017-06-01

    The diagnosis of cerebral venous sinus thrombosis still remains a real challenge. Seizure, unusual headache with sudden onset, unexplained persistently unilateral vascular headache and neurologic deficit-which is difficult to be attributed to a vascular territory are some of the suggestive symptoms. An isolated sixth nerve palsy is discussed as a rare presentation for cerebral venous thrombosis. Following the extensive investigation to rule out other possible diagnoses, magnetic resonance venogram revealed the final etiology of sixth nerve palsy that was ipsilateral left transverse sinus thrombosis; therefore, anticoagulant treatment with low molecular weight heparin was administered. Rapid and accurate diagnosis and treatment cause to achieve excellent outcomes for most patients. Considering different clinical features, risk factors and high index of suspicion are helpful to reach the diagnosis. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Twist and Shout? Developing Sixth-Form Students' Thinking about Historical Interpretation

    Science.gov (United States)

    Chapman, Arthur

    2011-01-01

    Understanding historical interpretation involves understanding how historical knowledge is constructed. How do sixth formers model historical epistemology? In this article Arthur Chapman examines a small sample of data relating to sixth form students' ideas about why historians construct differing interpretations of the past. He argues that…

  8. Sixth international workshop on linear colliders. Proceedings

    International Nuclear Information System (INIS)

    Urakawa, Junji

    1995-08-01

    The sixth international workshop on linear colliders (LC95) was held by KEK at Tsukuba Center for Institute. In the workshop 8 parallel working group were organized: WG1 (beam sources and injection linacs), WG2 (damping rings and bunch compressors), WG3 (a: RF sources and structures, b: superconducting cavities, c: two beam accelerators), WG4 (beam dynamics in main linacs), WG5 (final focus and integration regions), WG6 (beam instrumentation), WG7 (overall parameters and construction techniques), WG8 (gamma-gamma collider and miscellaneous). This issue compiles materials which were used in the workshop. (J.P.N.)

  9. Sixth international workshop on linear colliders. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Urakawa, Junji [ed.

    1995-08-01

    The sixth international workshop on linear colliders (LC95) was held by KEK at Tsukuba Center for Institute. In the workshop 8 parallel working group were organized: WG1 (beam sources and injection linacs), WG2 (damping rings and bunch compressors), WG3 (a: RF sources and structures, b: superconducting cavities, c: two beam accelerators), WG4 (beam dynamics in main linacs), WG5 (final focus and integration regions), WG6 (beam instrumentation), WG7 (overall parameters and construction techniques), WG8 (gamma-gamma collider and miscellaneous). This issue compiles materials which were used in the workshop. (J.P.N.).

  10. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, paranoid personality disorder diagnosis: a unitary or a two-dimensional construct?

    Science.gov (United States)

    Falkum, Erik; Pedersen, Geir; Karterud, Sigmund

    2009-01-01

    This article examines reliability and validity aspects of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) paranoid personality disorder (PPD) diagnosis. Patients with personality disorders (n = 930) from the Norwegian network of psychotherapeutic day hospitals, of which 114 had PPD, were included in the study. Frequency distribution, chi(2), correlations, reliability statistics, exploratory, and confirmatory factor analyses were performed. The distribution of PPD criteria revealed no distinct boundary between patients with and without PPD. Diagnostic category membership was obtained in 37 of 64 theoretically possible ways. The PPD criteria formed a separate factor in a principal component analysis, whereas a confirmatory factor analysis indicated that the DSM-IV PPD construct consists of 2 separate dimensions as follows: suspiciousness and hostility. The reliability of the unitary PPD scale was only 0.70, probably partly due to the apparent 2-dimensionality of the construct. Persistent unwarranted doubts about the loyalty of friends had the highest diagnostic efficiency, whereas unwarranted accusations of infidelity of partner had particularly poor indicator properties. The reliability and validity of the unitary PPD construct may be questioned. The 2-dimensional PPD model should be further explored.

  11. Human Resources Administration in Education: A Management Approach. Sixth Edition.

    Science.gov (United States)

    Rebore, Ronald W.

    This book reflects the changing aspects of school human-resources management. Current concerns include the impact of new laws related to disabilities, civil rights, family and medical leave, and the testing of school bus drivers for alcohol and controlled substances. Also examined are human resources' responsibilities to military reservists and…

  12. Solar building construction. Special edition of the journal 'Sonnenenergie'; Solares Bauen. Sonderheft der Sonnenenergie

    Energy Technology Data Exchange (ETDEWEB)

    Rust, A. (comp.)

    2003-10-01

    This special issue of October 2003 reviews solar architecture, planning, applications, technology, market and knowledge. Subjects: Falkenweg housing development; Q-Cells solar factory; Modehaus Zara building; Haus Westermayr McCready building; Federal Environmental Office building, Dessau; 'Haus im Himmel' building; NRW state representatives building in Berlin; Zero-emission building 'Sunny Woods', Zurich; Hellerau workshop buildings, Dresden; HOCHTIEF PRISMA Haus building, Frankfurt; Solar government buildings, Berlin; SOLARBAU programme; Energy supply concepts based on photovoltaic power supply; Solar cooling; Photovoltaic lamellas; Solar building construction; Solar contracting; Solar building modernisation; Integrated PV systems in Europe; Living in passive buildings; Funding programmes for renewable energy sources and building construction. (orig./AKF)

  13. Reaching with the sixth sense

    DEFF Research Database (Denmark)

    Reichenbach, Alexandra; Bresciani, Jean-Pierre; Bulthoff, Heinrich H.

    2016-01-01

    The vestibular system constitutes the silent sixth sense: It automatically triggers a variety of vital reflexes to maintain postural and visual stability. Beyond their role in reflexive behavior, vestibular afferents contribute to several perceptual and cognitive functions and also support volunt...

  14. Construct Validity of the Movement Assessment Battery for Children-Second Edition Test in Preschool Children with Respect to Age and Gender

    Directory of Open Access Journals (Sweden)

    Jakub Kokštejn

    2018-01-01

    Full Text Available BackgroundThe Movement Assessment Battery for Children-second edition (MABC-2 Age Band 1 is widely used to identify preschoolers with motor difficulties. Despite unsatisfactory construct validity of the original three-factor model, MABC-2 (manual dexterity, aiming and catching, and balance, previous research has not considered possible age and gender differences throughout the entire preschool period.AimThe aim of this study was to verify the construct validity of the MABC-2 Age Band 1 in a population of Czech preschoolers with respect to age and gender.MethodsUsing data from 510 Czech preschoolers (3–6 years; 4.9 ± 1.1 years, confirmatory factor analyses (CFA were used for each age category and gender.ResultsThe goodness-of-fit indices of CFA supported the original three-factor model of the MABC-2 only in 3- and 4-year-old children, and in boys (3–6 years. Low factor loadings and ceiling effects of several test items (Drawing Trail, Walking Heels Raised, and Jumping on Mats seem to be a probable cause of weak fit indices in 5- and 6-year-old children and in girls (3–6 years.ConclusionThese results suggest that the MABC-2 can be a valid tool for assessing motor development and identifying motor difficulties among 3- to 4-year olds, and generally fits better for preschool boys in the Czech Republic. However, in 5- to 6-year olds, ceiling effects and a low power of discrimination was found for the Drawing Trail, Walking Heels Raised, and Jumping on Mats tests. Therefore, the three-factor model is not appropriate for all preschoolers, and separate norms should be established for each age and gender.

  15. Construct Validity of the Movement Assessment Battery for Children-Second Edition Test in Preschool Children with Respect to Age and Gender.

    Science.gov (United States)

    Kokštejn, Jakub; Musálek, Martin; Tufano, James J

    2018-01-01

    The Movement Assessment Battery for Children-second edition (MABC-2) Age Band 1 is widely used to identify preschoolers with motor difficulties. Despite unsatisfactory construct validity of the original three-factor model, MABC-2 (manual dexterity, aiming and catching, and balance), previous research has not considered possible age and gender differences throughout the entire preschool period. The aim of this study was to verify the construct validity of the MABC-2 Age Band 1 in a population of Czech preschoolers with respect to age and gender. Using data from 510 Czech preschoolers (3-6 years; 4.9 ± 1.1 years), confirmatory factor analyses (CFA) were used for each age category and gender. The goodness-of-fit indices of CFA supported the original three-factor model of the MABC-2 only in 3- and 4-year-old children, and in boys (3-6 years). Low factor loadings and ceiling effects of several test items (Drawing Trail, Walking Heels Raised, and Jumping on Mats) seem to be a probable cause of weak fit indices in 5- and 6-year-old children and in girls (3-6 years). These results suggest that the MABC-2 can be a valid tool for assessing motor development and identifying motor difficulties among 3- to 4-year olds, and generally fits better for preschool boys in the Czech Republic. However, in 5- to 6-year olds, ceiling effects and a low power of discrimination was found for the Drawing Trail, Walking Heels Raised, and Jumping on Mats tests. Therefore, the three-factor model is not appropriate for all preschoolers, and separate norms should be established for each age and gender.

  16. The Sixth Great Mass Extinction

    Science.gov (United States)

    Wagler, Ron

    2012-01-01

    Five past great mass extinctions have occurred during Earth's history. Humanity is currently in the midst of a sixth, human-induced great mass extinction of plant and animal life (e.g., Alroy 2008; Jackson 2008; Lewis 2006; McDaniel and Borton 2002; Rockstrom et al. 2009; Rohr et al. 2008; Steffen, Crutzen, and McNeill 2007; Thomas et al. 2004;…

  17. Marihuana and Health. Sixth Annual Report to the U.S. Congress from the Secretary of Health, Education, and Welfare, 1976.

    Science.gov (United States)

    National Inst. on Drug Abuse (DHEW/PHS), Rockville, MD.

    This edition, the sixth in the series of annual reports, is a nontechnical summary updating developments in marihuana research with selected references from the fifth edition. Areas of discussion include: (1) nature and extent of marihuana use in the United States; (2) marihuana use among high school seniors; (3) an overview of use trends; (4)…

  18. genome editing

    Indian Academy of Sciences (India)

    2016-02-11

    Feb 11, 2016 ... terms in molecular biology, but I have the premonition that we are living a similar event, with identically dra- ... meaning of 'editing' occurred in the French language and in biology. In both cases, computers played ..... Tiegs SL, Russell DM and Nemazee D 1993 Receptor editing in self-reactive bone marrow.

  19. Sixth International Workshop and Summer School on Plasma Physics 2014

    International Nuclear Information System (INIS)

    2016-01-01

    who sent their manuscripts and passed through the (sometimes heavy and troublesome) refereeing and editing procedure and our referees for their patience and considerable effort to improve the manuscripts. We would like to express our gratitude to the invited lecturers who were willing to pay the participation fee. In this way, in addition to the intellectual support they provided by means of their excellent lectures, they also supported the school financially. We are obliged also to Bolkan Construction JSC for the sponsorship. E. Benova and M. Atanasova (paper)

  20. Sixth taste – starch taste?

    Directory of Open Access Journals (Sweden)

    Zygmunt Zdrojewicz

    2017-06-01

    Full Text Available Scientists from Oregon State University, USA, came up with the newest theory of the sixth taste – starch taste that might soon join the basic five tastes. This argument is supported by studies done on both animals and humans, the results of which seem to indicate the existence of separate receptors for starch taste, others than for sweet taste. Starch is a glucose homopolymer that forms an α-glucoside chain called glucosan or glucan. This polysaccharide constitutes the most important source of carbohydrates in food. It can be found in groats, potatoes, legumes, grains, manioc and corn. Apart from its presence in food, starch is also used in textile, pharmaceutical, cosmetic and stationery industries as well as in glue production. This polysaccharide is made of an unbranched helical structure – amylose (15–20%, and a structure that forms branched chains – amylopectin (80–85%. The starch structure, degree of its crystallisation or hydration as well as its availability determine the speed of food-contained starch hydrolysis by amylase. So far, starch has been considered tasteless, but the newest report shows that for people of different origins it is associated with various aliments specific for each culture. Apart from a number of scientific experiments using sweet taste inhibitors, the existence of the sixth taste is also confirmed by molecular studies. However, in order to officially include starch taste to the basic human tastes, it must fulfil certain criteria. The aim of the study is to present contemporary views on starch.

  1. Benign Recurrent Sixth Cranial Nerve Palsies

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2009-06-01

    Full Text Available A retrospective chart review of a cohort of 253 pediatric patients with sixth nerve palsies uncovered 30 cases of benign sixth nerve palsy, of which 9 were recurrent, in a study at University of Pennsylvania School of Medicine, Philadelphia.

  2. Construction

    Science.gov (United States)

    2002-01-01

    Harbor Deepening Project, Jacksonville, FL Palm Valley Bridge Project, Jacksonville, FL Rotary Club of San Juan, San Juan, PR Tren Urbano Subway...David. What is nanotechnology? What are its implications for construction?, Foresight/CRISP Workshop on Nanotechnology, Royal Society of Arts

  3. SIXTH ERDA WORKSHOP ON PERSONNEL NEUTRON DOSIMETRY

    Energy Technology Data Exchange (ETDEWEB)

    Vallario, E. J.; Hankins, D. E.; Bramson, P. E.

    1977-07-11

    This workshop was the sixth of a series and was held on July 11 and 12, 1977, at the Oak Ridge National Laboratory in Oak Ridge, Tennessee. Those presenting papers at the Sixth Workshop prepared summary reports of their recent work for inclusion in this document. The reports are reproduced here as submitted by the participants, with only minor editing. This year's Workshop took a decidedly international flavor, with participants from seven countries in addition to the United States. The significance of this group's contributions has raised the possibility that the next Neutron Dosimetry Workshop may be held in Europe. Of particular interest at the Workshop was the keynote address by Dr. Harald Rossi. He commented that there is evidence that 1) accepted values of RBE for low absorbed doses of neutrons may be low by an order of magnitude or more and 2) the risk of leukemia is significant at 0.5 rad to the bone narrow. A reduction of the limit for permissible neutron exposure, which could result from consideration of this information, would necessitate major improvements in our "middle ages" neutron dosimetry. A number of participants reported conversions to thermoluminescent dosimeter (TLD) systems. This move has not been unanimous, however, as there were several reports of apparently satisfactory fission fragment, activation foil, and NTA film dosimeters. While thementionof NTA film resulted in the usual discussion of energy cut off and humidity effects, it seems the use of NTA in accelerator environments still has some merit. Discussion of fission fragment dosimeters centered around track etching techniques, which have shown some improvement. Of particular interest was Tommasino's report on the use of polycarbonate centrifuge tubes as the sensitive element. Thermally stimulated exoelectron emission (TSEE), never very popular for personnel dosimetry, has lost additional ground with the report that the neutron/gamma response ratio is much less than

  4. Cluster editing

    DEFF Research Database (Denmark)

    Böcker, S.; Baumbach, Jan

    2013-01-01

    . The problem has been the inspiration for numerous algorithms in bioinformatics, aiming at clustering entities such as genes, proteins, phenotypes, or patients. In this paper, we review exact and heuristic methods that have been proposed for the Cluster Editing problem, and also applications...

  5. genome editing

    Indian Academy of Sciences (India)

    2016-02-11

    Feb 11, 2016 ... What history tells us. XL. The success story of the expression 'genome editing'. MICHEL MORANGE. Centre Cavaillès, République des Savoirs: Lettres, Sciences, Philosophie USR 3608, Ecole. Normale Supérieure, 29 Rue d'Ulm, 75230, Paris Cedex 05, France. (Fax, 33-144-323941; Email, ...

  6. Are most sixth nerve palsies really paralytic?

    Science.gov (United States)

    Altintas, Ayse Gul; Arifoglu, Hasan Basri; Dal, Derya; Simsek, Saban

    2011-01-01

    Etiology and date of palsy are two important parameters that affect the treatment protocol of sixth nerve palsies. This study evaluated the treatment protocols and outcomes of treatment in sixth nerve palsies. Thirty-four patients who had sixth nerve palsy were included. Botulinum toxin A (BTX) injection was performed on patients with acute sixth nerve palsy and paresis (BTX group), whereas chronic cases received only horizontal surgery (surgery group). All patients in the BTX group received a BTX injection into the ipsilateral medial rectus muscle. Patients in the surgery group underwent either ipsilateral medial rectus recession or recession combined with lateral rectus resection without the transposition procedure. Fifteen patients were treated with a BTX injection to the medial rectus muscle. One patient underwent ipsilateral medial rectus muscle recession and 6 patients received both medial rectus recession and lateral rectus resection in the same session. Measurement of esotropia was 24.9 prism diopters (PD) (range: 18 to 35 PD) before treatment in the BTX group. The recovery rate was 86.6% (13 of 15) without any residual deviation. In the surgery group, the mean preoperative deviation was 35.1 PD (range: 14 to 75 PD), which decreased to mean 2.57 PD (range: 0 to 10 PD) postoperatively. The achievement of orthotropia rate was 85.7%. BTX injection was found to be an effective treatment because it prevented medial rectus contraction in acute sixth nerve palsies. Correction of deviation with the recession of contracted medial rectus muscles and resection of lateral rectus muscles without the need of transposition in chronic sixth nerve palsy testified that most sixth nerve palsies involve partial paralysis rather than complete paralysis. Copyright 2011, SLACK Incorporated.

  7. Proceedings of the Sixth General Meeting of the International VLBI Service for Geodesy and Astrometry

    Science.gov (United States)

    Behrend, Dirk (Editor); Baver, Karen D. (Editor)

    2010-01-01

    This volume is the proceedings of the sixth General Meeting of the International VLBI Service for Geodesy and Astrometry (IVS), held in Hobart, Tasmania, Australia, February 7-13, 2010. The contents of this volume also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/gm2010. The keynote of the sixth GM was the new perspectives of the next generation VLBI system under the theme "VLBI2010: From Vision to Reality". The goal of the meeting was to provide an interesting and informative program for a wide cross-section of IVS members, including station operators, program managers, and analysts. This volume contains 88 papers. All papers were edited by the editors for usage of the English language, form, and minor content-related issues.

  8. Servant Leadership in English Sixth Form Colleges: What Do Teachers Tell Us?

    Science.gov (United States)

    Stoten, David William

    2013-01-01

    Purpose: The purpose of this paper is to investigate whether servant leadership can be applied to college management. The research methodology involved questionnaire and co-constructed discussion eliciting the views of teachers on how they interpret leadership in a sixth form college. Three other models of leadership were discussed along with…

  9. Blow-up of solutions for the sixth-order thin film equation with ...

    Indian Academy of Sciences (India)

    Abstract. In this paper, a sixth-order parabolic thin film equation with the initial boundary condi- tion is considered. By using the improved energy estimate method and by constructing second-order elliptic problem, a blow-up result for certain solution with positive initial energy is established, which is an improve over the ...

  10. Congenital sixth nerve palsy with associated anomalies

    Directory of Open Access Journals (Sweden)

    Nirupama Kasturi

    2017-01-01

    Full Text Available Congenital abduction deficit is most likely due to Duane's retraction syndrome as congenital abducens nerve palsy is very rare. We report two cases of infantile abduction deficit due to sixth nerve palsy associated with other anomalies to highlight the importance of including neuroimaging in the evaluation of an infant presenting with a limitation of abduction.

  11. Congenital sixth nerve palsy with associated anomalies.

    Science.gov (United States)

    Kasturi, Nirupama

    2017-10-01

    Congenital abduction deficit is most likely due to Duane's retraction syndrome as congenital abducens nerve palsy is very rare. We report two cases of infantile abduction deficit due to sixth nerve palsy associated with other anomalies to highlight the importance of including neuroimaging in the evaluation of an infant presenting with a limitation of abduction.

  12. Rapid construction of multiple sgRNA vectors and knockout of the Arabidopsis IAA2 gene using the CRISPR/Cas9 genomic editing technology.

    Science.gov (United States)

    Liu, Ding-yuan; Qiu, Ting; Ding, Xiao-hui; Li, Miao-miao; Zhu, Mu-yuan; Wang, Jun-hui

    2016-08-01

    IAA2 is a member of the Aux/IAA auxin responsive gene family in Arabidopsis thaliana. No iaa2 mutant has been reported until now, thus hindering its further mechanistic investigations. The normal genomic editing technology of CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) uses only a single guide RNA (sgRNA) to target one site in a specific gene, and the gene knockout efficiency is not high. Instead, multiple sgRNAs can target multiple sites; therefore, the efficiency may be improved. In the present investigation, we used the golden-gate cloning strategy and two rounds of PCR reactions to combine three sgRNAs in the same entry vector. The final expression vector was obtained by LR reactions with the destination vector containing the Cas9 expression cassette. Four out of the six sgRNAs were effective, and we also obtained a lot of insertion and deletion mutations. Compared with one sgRNA approach, multiple sgRNAs displayed higher gene-knockout efficiency and produced more germ-line mutants. Thus, we established a more rapid and efficient method and generated five mutants for further studies of IAA2 functions.

  13. Evaluating multiple polylogarithm values at sixth roots of unity up to weight six

    Science.gov (United States)

    Henn, J. M.; Smirnov, A. V.; Smirnov, V. A.

    2017-06-01

    We evaluate multiple polylogarithm values at sixth roots of unity up to weight six, i.e. of the form G (a1 , … ,aw ; 1) where the indices ai are equal to zero or a sixth root of unity, with a1 ≠ 1. For w ≤ 6, we construct bases of the linear spaces generated by the real and imaginary parts of G (a1 , … ,aw ; 1) and obtain a table for expressing them as linear combinations of the elements of the bases.

  14. [Genome editing of industrial microorganism].

    Science.gov (United States)

    Zhu, Linjiang; Li, Qi

    2015-03-01

    Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

  15. 75 FR 23823 - Sixth Northwest Electric Power and Conservation Plan

    Science.gov (United States)

    2010-05-04

    ... POWER AND CONSERVATION PLANNING COUNCIL Sixth Northwest Electric Power and Conservation Plan AGENCY: Pacific Northwest Electric Power and Conservation Planning Council (Northwest Power and Conservation Council; the Council). ACTION: Notice of adoption of the Sixth Northwest Electric Power and Conservation...

  16. Basic Wiring. Third Edition. Teacher Edition [and] Student Edition.

    Science.gov (United States)

    Kaltwasser, Stan; Flowers, Gary; Blasingame, Don; Batson, Larry; Ipock, Dan; Carroll, Charles; Friesen, Wade; Fleming, Glenn

    This publication contains both a teacher edition and a student edition of materials for a foundation course in an electrical wiring program. The course introduces basic concepts and skills that are prerequisites to residential wiring and commercial and industrial wiring courses. The contents of the materials are tied to measurable and observable…

  17. Diesel Technology: Introduction. Teacher Edition [and] Student Edition. Second Edition.

    Science.gov (United States)

    Joerschke, John D.; Eichhorn, Lane

    This complete teacher edition of a diesel technology course consists of introductory pages, teacher pages, and the student edition. The introductory pages provide these tools: training and competency profile; National Automotive Technicians Education Foundation Crosswalk; instructional/task analysis; basic skills icons and classifications; basic…

  18. Capecitabine and sixth cranial nerve palsy

    Directory of Open Access Journals (Sweden)

    Dasgupta Sonali

    2010-01-01

    Full Text Available Capecitabine is an oral chemotherapeutic agent converted to 5 flourouracil (5-FU. Neurotoxicity associated with the medication encompasses both central and peripheral nervous systems. We describe a 60 year old man with colonic carcinoma who developed diplopia due to a sixth nerve palsy following the use of capecitabine which is an orally administered prodrug of 5-FU. An MRI of brain did not reveal a space occupying lesion or vascular insult to account for his cranial nerve palsy. The sixth nerve palsy resolved spontaneously once capecitabine was withdrawn. Physicians in all walks of life are increasingly likely to come across such patients and should familiarize themselves with toxicities consequent to chemotherapy. Further research is needed to elucidate the cause of capecitabine associated neurotoxicity.

  19. Capecitabine and sixth cranial nerve palsy.

    Science.gov (United States)

    Dasgupta, Sonali; Adilieje, Chineme; Bhattacharya, Amlan; Smith, Bruce; Sheikh, Moeen ul Haq

    2010-01-01

    Capecitabine is an oral chemotherapeutic agent converted to 5 fluorouracil (5-FU). Neurotoxicity associated with the medication encompasses both central and peripheral nervous systems. We describe a 60 year old man with colonic carcinoma who developed diplopia due to a sixth nerve palsy following the use of capecitabine which is an orally administered prodrug of 5-FU. An MRI of brain did not reveal a space occupying lesion or vascular insult to account for his cranial nerve palsy. The sixth nerve palsy resolved spontaneously once capecitabine was withdrawn. Physicians in all walks of life are increasingly likely to come across such patients and should familiarize themselves with toxicities consequent to chemotherapy. Further research is needed to elucidate the cause of capecitabine associated neurotoxicity.

  20. Belgian Federalism after the Sixth State Reform

    Directory of Open Access Journals (Sweden)

    Goossens Jurgen

    2015-11-01

    Full Text Available This paper highlights the most important institutional evolutions of Belgian federalism stemming from the implementation of the sixth state reform (2012-2014. This reform inter alia included a transfer of powers worth 20 billion euros from the federal level to the level of the federated states, a profound reform of the Senate, and a substantial increase in fiscal autonomy for the regions. This contribution critically analyses the current state of Belgian federalism. Although the sixth state reform realized important and long-awaited changes, further evolutions are to be expected. Since the Belgian state model has reached its limits with regard to complexity and creativity, politicians and academics should begin to reflect on the seventh state reform with the aim of increasing the transparency of the current Belgian institutional labyrinth.

  1. Sixth underground coal-conversion symposium

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    The sixth annual underground coal conversion symposium was held at Shangri-la near Afton, Oklahoma, July 13 to 17, 1980. Sessions were developed to: Doe Field Programs, Major Industry Activity, Mathematical Modeling, Laboratory Studies, Environmental Studies, Economics, Instruments and Controls, and General Topics. Fifty-two papers from the proceedings have been entered individually into EDB and ERA. Thirteen papers had been entered previously from other sources. (LTN)

  2. Wikipedia editing dynamics

    Science.gov (United States)

    Gandica, Y.; Carvalho, J.; Sampaio dos Aidos, F.

    2015-01-01

    A model for the probabilistic function followed in editing Wikipedia is presented and compared with simulations and real data. It is argued that the probability of editing is proportional to the editor's number of previous edits (preferential attachment), to the editor's fitness, and to an aging factor. Using these simple ingredients, it is possible to reproduce the results obtained for Wikipedia editing dynamics for a collection of single pages as well as the averaged results. Using a stochastic process framework, a recursive equation was obtained for the average of the number of edits per editor that seems to describe the editing behavior in Wikipedia.

  3. Therapeutic results in sixth nerve palsy

    Directory of Open Access Journals (Sweden)

    Pruna Violeta-Ioana

    2015-03-01

    Full Text Available Authors aim to assess through a retrospective study the efficiency of different therapeutic methods used in VIth nerve palsy. 60 patients with VIth nerve palsy, admitted and treated in Oftapro Clinic, were divided into two groups: a group with partial dysfunction (paresis of sixth nerve and a group with the complete abolition of neuromuscular function (VIth nerve palsy. Initial examination included assessment of neuromuscular function, binocular vision and existence of medial rectus muscle contracture (ipsi- and contralateral and contralateral lateral rectus inhibitory palsy. Neuromuscular dysfunction was graded from - 8 (paralysis to 0 (normal abduction. Therapeutic modalities ranged from conservative treatment (occlusion, prism correction, botulinum toxin chemodenervation and surgical treatment: medial rectus recession + lateral rectus resection, in cases of paresis, and transposition procedures (Hummelscheim and full tendon transfer in cases of sixth nerve palsy. Functional therapeutic success was defined as absence of diplopia in primary position, with or without prism correction, and surgical success was considered obtaining orthoptic alignment in primary position or a small residual deviation (under 10 PD. 51 patients had unilateral dysfunction, and 9 patients had bilateral VI-th nerve dysfunction. 8 patients had associated fourth or seventh cranial nerves palsy. The most common etiology was traumatic, followed by tumor and vascular causes. There were 18 cases of spontaneous remission, partial or complete (4-8 months after the onset, and 6 cases enhanced by botulinum toxin chemodenervation. 17 paretic eyes underwent surgery, showing a very good outcome, with restoration of binocular single vision. The procedure of choice was recession of medial rectus muscle, combined with resection of lateral rectus muscle. All patients with sixth nerve palsy underwent surgery, except one old female patient, who refused surgery. Hummelscheim procedure was

  4. The role of RNA editing in dynamic environments

    Energy Technology Data Exchange (ETDEWEB)

    Rocha, L. M. (Luis Mateus); Huang, C. F. (Chien-Feng)

    2004-01-01

    This paper presents a computational methodology based on Genetic Algorithms with Genotype Editing (GAE) for investigating the role of RNA editing in dynamic environments. This model is constructed based on several genetic editing characteristics that are gleaned from the RNA editing system as observed in several organisms. We have previously expanded the traditional Genetic Algorithm (GA) with artificial editing mechanisms (Rocha, 1995, 1997), and studied the benefits of including straightforward Genotype Editing in GA for several machine learning problems (Huang and Rocha, 2003, 2004). We show that the incorporation of genotype editing provides a means for artificial agents with genetic descriptions to gain greater phenotypic plasticity. Artificial agents use genotype edition to their advantage by linking it to environmental context. The ability to link changes in the environment with editing parameters gives organisms an adaptive advantage as genotype expression can become contextually regulated. The study of this RNA editing model in changing environments has shed some light into the evolutionary implications of RNA editing. We expect that our methodology will both facilitate determining the evolutionary role of RNA editing in biology, and advance the current state of research in Evolutionary Computation and Artificial Life.

  5. The art of editing RNA structural alignments

    DEFF Research Database (Denmark)

    Andersen, Ebbe Sloth

    2014-01-01

    Manual editing of RNA structural alignments may be considered more art than science, since it still requires an expert biologist to take multiple levels of information into account and be slightly creative when constructing high-quality alignments. Even though the task is rather tedious, it is re......Manual editing of RNA structural alignments may be considered more art than science, since it still requires an expert biologist to take multiple levels of information into account and be slightly creative when constructing high-quality alignments. Even though the task is rather tedious...

  6. The Six Syndromes of the Sixth Cranial Nerve

    Directory of Open Access Journals (Sweden)

    Mohsen Azarmina

    2013-01-01

    Full Text Available The sixth cranial nerve runs a long course from the brainstem to the lateral rectus muscle. Based on the location of an abnormality, other neurologic structures may be involved with the pathology related to this nerve. Sixth nerve palsy is frequently due to a benign process with full recovery within weeks, yet caution is warranted as it may portend a serious neurologic process. Hence, early diagnosis is often critical for some conditions that present with sixth nerve palsy. This article outlines a simple clinical approach to sixth nerve palsy based on its anatomy.

  7. The six syndromes of the sixth cranial nerve.

    Science.gov (United States)

    Azarmina, Mohsen; Azarmina, Hossein

    2013-04-01

    The sixth cranial nerve runs a long course from the brainstem to the lateral rectus muscle. Based on the location of an abnormality, other neurologic structures may be involved with the pathology related to this nerve. Sixth nerve palsy is frequently due to a benign process with full recovery within weeks, yet caution is warranted as it may portend a serious neurologic process. Hence, early diagnosis is often critical for some conditions that present with sixth nerve palsy. This article outlines a simple clinical approach to sixth nerve palsy based on its anatomy.

  8. Sixth Meeting on CPT and Lorentz Symmetry

    CERN Document Server

    CPT and Lorentz Symmetry

    2014-01-01

    This book contains the Proceedings of the Sixth Meeting on CPT and Lorentz Symmetry, held at Indiana University in Bloomington on June 17–21, 2013. The Meeting focused on tests of these fundamental symmetries and on related theoretical issues, including scenarios for possible violations. Topics covered at the meeting include searches for CPT and Lorentz violations involving: accelerator and collider experiments; atomic, nuclear, and particle decays; birefringence, dispersion, and anisotropy in cosmological sources; clock-comparison measurements; electromagnetic resonant cavities and lasers; tests of the equivalence principle; gauge and Higgs particles; high-energy astrophysical observations; laboratory tests of gravity; matter interferometry; neutrino oscillations and propagation; oscillations and decays of neutral mesons; particle–antiparticle comparisons; post-newtonian gravity in the solar system and beyond; second- and third-generation particles; space-based missions; spectroscopy of hydrogen and ant...

  9. Sixth Computational Biomechanics for Medicine Workshop

    CERN Document Server

    Nielsen, Poul MF; Miller, Karol; Computational Biomechanics for Medicine : Deformation and Flow

    2012-01-01

    One of the greatest challenges for mechanical engineers is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, biomedical sciences, and medicine. This book is an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine. Computational Biomechanics for Medicine: Deformation and Flow collects the papers from the Sixth Computational Biomechanics for Medicine Workshop held in Toronto in conjunction with the Medical Image Computing and Computer Assisted Intervention conference. The topics covered include: medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, and medical robotics.

  10. Sixth International Conference on Complex Systems

    CERN Document Server

    Minai, Ali; Bar-Yam, Yaneer; Unifying Themes in Complex Systems

    2008-01-01

    The International Conference on Complex Systems (ICCS) creates a unique atmosphere for scientists of all fields, engineers, physicians, executives, and a host of other professionals to explore the common themes and applications of complex systems science. In June 2006, 500 participants convened in Boston for the sixth ICCS, exploring an array of topics, including networks, systems biology, evolution and ecology, nonlinear dynamics and pattern formation, as well as neural, psychological, psycho-social, socio-economic, and global systems. This volume selects 77 papers from over 300 presented at the conference. With this new volume, Unifying Themes in Complex Systems continues to build common ground between the wide-ranging domains of complex systems science.

  11. IAEA research contracts. Sixth annual report

    International Nuclear Information System (INIS)

    1966-01-01

    This volume is the sixth annual report and presents full summaries of 37 final reports from contracts, sponsored under the Agency's Research Contract Programme, which were completed during 1965. Including these, a total of 136 summaries have been published in the various fields in which support is provided under the IAEA Research contract program. In every case the summary of the contractor's final report has been prepared by that member of the Agency's scientific staff who has been most closely connected with the particular branch of research concerned. The scientific data are the responsibility of the contractor, though the Agency is responsible for any additional observations. The reports presented are related to research in the field of radioactive waste management and environmental sciences; health physics and radiation protection; radiobiology; safeguards methods; nuclear reactors physics and nuclear fuels; radioisotope applications in agriculture, medicine and hydrology

  12. Benign Recurrent Sixth Nerve Palsy in a Child

    Directory of Open Access Journals (Sweden)

    Rita Gonçalves

    2017-01-01

    Full Text Available Benign recurrent sixth nerve palsy in children is rare. It typically occurs following viral illness or immunization, and prognosis is usually excellent. However, it is always a diagnosis of exclusion given the more serious alternative causes. Therefore, a thorough examination with brain imaging is recommended. The authors report a child with six recurrent episodes of isolated benign sixth nerve palsy.

  13. Benign Recurrent Sixth Nerve Palsy in a Child.

    Science.gov (United States)

    Gonçalves, Rita; Coelho, Pedro; Menezes, Carlos; Ribeiro, Isabel

    2017-01-01

    Benign recurrent sixth nerve palsy in children is rare. It typically occurs following viral illness or immunization, and prognosis is usually excellent. However, it is always a diagnosis of exclusion given the more serious alternative causes. Therefore, a thorough examination with brain imaging is recommended. The authors report a child with six recurrent episodes of isolated benign sixth nerve palsy.

  14. Benign recurrent sixth nerve palsy in an infant.

    Science.gov (United States)

    Jukes, Catherine

    2014-10-01

    Acquired sixth nerve palsies in children are rare and may indicate serious underlying pathologies such as tumors, trauma, or raised intracranial pressure. A case of an infant with three episodes of benign sixth nerve palsy is presented. Copyright 2014, SLACK Incorporated.

  15. Green Power Marketing in the United States: A Status Report, Sixth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Swezey, B.

    2003-10-01

    Voluntary consumer decisions to purchase electricity supplied from renewable energy sources represent a powerful market support mechanism for renewable energy development. Beginning in the early 1990s, a small number of U.S. utilities began offering''green power'' options to their customers. Since then, these products have become more prevalent both from utilities and in states that have introduced competition into their retail electricity markets. Today, nearly 50% of all U.S. consumers have an option to purchase some type of green power product from a retail electricity provider. Currently, more than 350 investor-owned utilities, rural electric cooperatives, and other publicly owned utilities in 33 states offer green power programs. This report provides an overview of green power marketing activity in the United States. It describes green power product offerings, consumer response, and recent industry trends. The three distinct markets for green power are discussed in turn.

  16. United States Air Force Statistical Digest, Fiscal Year 1951. Sixth Edition

    Science.gov (United States)

    1952-11-18

    Capacit1’ No"""- Occupied Dot in Norma ’- Occupied lormaJ. Ocoupbd No"""- Oooupied lormaJ. OCcupied 10"""- Oocupl.d Capll.cltT or Uss tor Cllp801tJ’ or...e. 13 8,853 - 13 8,853 - - - Panoramic Adaptor, APA -41 •• "•••••• " ••• •• 6 17,456 - 6 17,456 . - - Radio Ccapasll, AN/crP.P-7...191 4,735,995 - 191 4,735,995 - - - A1rbOl’Dll DF :Ju1pmtent, AN/ APA -24 •••••••• •• 6 75,848 - 6 75,846 - - - Radar Set, All APQ-43 and

  17. Multiplex editing system

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a multiplex editing system. The system allows multiple editing of nucleic acid sequences such as genomic sequences, such as knockins of genes of interest in a genome, knockouts of genomic sequences and/or allele replacement. Also provided herein are a method...

  18. Sixth national report of Brazil for the nuclear safety convention

    International Nuclear Information System (INIS)

    2013-01-01

    Brazil has presented periodically its National Report prepared by a group composed of representatives of the various Brazilian organizations with responsibilities related to nuclear safety. Due to the implications of the Fukushima nuclear accident in 2011, an Extraordinary National Report was presented in 2012. This Sixth National Report is an update of the Fifth National Report in relation to the Convention on Nuclear Safety articles and also an update of the Extraordinary Report with respect to the action taken related to lesson learned from the Fukushima accident. It includes relevant information for the period of 2010/2012. This document represents the national report prepared as a fulfillment of the brazilian obligations related to the Convention on Nuclear Safety. In chapter 2 some details are given about the existing nuclear installations. Chapter 3 provides details about the legislation and regulations, including the regulatory framework and the regulatory body. Chapter 4 covers general safety considerations as described in articles 10 to 16 of the Convention. Chapter 5 addresses to the safety of the installations during siting, design, construction and operation. Chapter 6 describes planned activities to further enhance nuclear safety. Chapter 7 presents the final remarks related to the degree of compliance with the Convention obligations

  19. Sixth national report of Brazil for the nuclear safety convention

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    Brazil has presented periodically its National Report prepared by a group composed of representatives of the various Brazilian organizations with responsibilities related to nuclear safety. Due to the implications of the Fukushima nuclear accident in 2011, an Extraordinary National Report was presented in 2012. This Sixth National Report is an update of the Fifth National Report in relation to the Convention on Nuclear Safety articles and also an update of the Extraordinary Report with respect to the action taken related to lesson learned from the Fukushima accident. It includes relevant information for the period of 2010/2012. This document represents the national report prepared as a fulfillment of the brazilian obligations related to the Convention on Nuclear Safety. In chapter 2 some details are given about the existing nuclear installations. Chapter 3 provides details about the legislation and regulations, including the regulatory framework and the regulatory body. Chapter 4 covers general safety considerations as described in articles 10 to 16 of the Convention. Chapter 5 addresses to the safety of the installations during siting, design, construction and operation. Chapter 6 describes planned activities to further enhance nuclear safety. Chapter 7 presents the final remarks related to the degree of compliance with the Convention obligations.

  20. Sixth national stakeholder workshop summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    On June 17--18, 1998, the Department of Energy`s (DOE) Office of Worker and Community Transition convened its sixth National Stakeholder Workshop at the Ramada Plaza Hotel Old Town in Alexandria, Virginia. Approximately 325 stakeholders attended representing DOE headquarters and field offices, contractors, labor organizations, state and local government, education and community interest groups. The meeting addressed the progress made on the issues and challenges identified at the last stakeholder`s meeting in Oakland, California on April 9--11, 1997. Also discussed were the full range of the Department`s work force issues and creative solutions to the inherent challenges of simultaneously implementing the Department`s post Cold-War mission, work force restructuring guidance, contract reform objectives, asset disposition, performance-based management requirements, and business process improvement policies. The format of the Workshop included several plenary sessions and a number of small group discussion sessions. The small group sessions focused on topics related to labor issues, work force restructuring, work force planning, community transition, and employee concerns. The sessions provided a wide range of views on worker and community transition issues. The plenary sessions of the Workshop included presentations on the following topics: welcome and introductions; opening remarks; building a better labor-management relationship; keynote speech from Secretary of Energy Federico Pena; meeting tomorrow`s challenges (early site closures); harnessing the contracting process to encourage local growth; and, the British experience in economic conversion.

  1. Sixth workshop on geothermal reservoir engineering: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Ramey, H.J. Jr.; Kruger, P. (eds.)

    1980-12-18

    INTRODUCTION TO THE PROCEEDINGS OF THE SIXTH GEOTHERMAL RESERVOIR ENGINEERING WORKSHOP, STANFORD GEOTHERMAL PROGRAM Henry J. Ramey, Jr., and Paul Kruger Co-Principal Investigators Ian G. Donaldson Program Manager Stanford Geothermal Program The Sixth Workshop on Geothermal Reservoir Engineering convened at Stanford University on December 16, 1980. As with previous Workshops the attendance was around 100 with a significant participation from countries other than the United States (18 attendees from 6 countries). In addition, there were a number of papers from foreign contributors not able to attend. Because of the success of all the earlier workshops there was only one format change, a new scheduling of Tuesday to Thursday rather than the earlier Wednesday through Friday. This change was in general considered for the better and will be retained for the Seventh Workshop. Papers were presented on two and a half of the three days, the panel session, this year on the numerical modeling intercomparison study sponsored by the Department of Energy, being held on the second afternoon. This panel discussion is described in a separate Stanford Geothermal Program Report (SGP-TR42). This year there was a shift in subject of the papers. There was a reduction in the number of papers offered on pressure transients and well testing and an introduction of several new subjects. After overviews by Bob Gray of the Department of Energy and Jack Howard of Lawrence Berkeley Laboratory, we had papers on field development, geopressured systems, production engineering, well testing, modeling, reservoir physics, reservoir chemistry, and risk analysis. A total of 51 papers were contributed and are printed in these Proceedings. It was, however, necessary to restrict the presentations and not all papers printed were presented. Although the content of the Workshop has changed over the years, the format to date has proved to be satisfactory. The objectives of the Workshop, the bringing together of

  2. Sixth negotiations meeting on the joint implementation of ITER

    International Nuclear Information System (INIS)

    Okumura, Y.

    2003-01-01

    During the Sixth ITER Negotiations Meeting (N6), the JA delegation reported that JA had sent a letter to China on 22 October 2002 on behalf of the ITER Negotiators in response to a letter from Mr. Liu, Vice Minister of Science and Technology of China. The Canadian delegation reported on the special informal ITER session at the IAEA Fusion Energy Conference in Lyon, France, and noted that it raised the ITER profile in a positive way. The EU delegation reported on the adoption, within the Sixth Framework Programme, of the Specific Euratom Programme, which gives an explicit basis for continuing activities in the period up to the end of 2006, including a provision of up to Euro 200 million for a possible start of ITER construction. The RF delegation reported that the ITER activities in the Russian Federation are conducted in accordance with the Federal Program (2002-2005) approved by the Russian Government. Funding for ITER activities in 2003 is expected to be on the same level as in previous years. It was reported that the mandate of the Russian delegation to participate in the Negotiations in 2003 is expected to be approved soon by the Government. The RF delegation also reported that they had received informal enquiries from the Republic of Korea about possible participation in ITER. Significant progress was also made on a wide range of other issues, including matters such as the treaty to implement ITER (the Joint Implementation Agreement - JIA), procurement allocation and the intellectual property rights that would accrue to participants in the project. The Negotiators agreed that the international organization responsible for implementing the project would be called the ITER International Fusion Energy Organization. The delegations noted the progress in developing the fifth draft of the JIA and charged the NSSG to elaborate further the JIA and Related Instruments. At the conclusion of the N6 meeting, the delegations reaffirmed their belief that the critical issues

  3. UN-EDITED VERSION

    Indian Academy of Sciences (India)

    8

    in a protein-protein interaction network (PPIN) (Kashyap 2016). This reciprocality produces robustness of proteins against mutation (Erten et al 2009). .... Among all forms of mental illnesses, Alzheimer's disease is devastatingly common. It is the sixth leading cause of death, especially among the elderly. Although there has ...

  4. Sixth Nerve Palsy from Cholesterol Granuloma of the Petrous Apex.

    Science.gov (United States)

    Roemer, Ségolène; Maeder, Philippe; Daniel, Roy Thomas; Kawasaki, Aki

    2017-01-01

    Herein, we report a patient who had an isolated sixth nerve palsy due to a petrous apex cholesterol granuloma. The sixth nerve palsy appeared acutely and then spontaneously resolved over several months, initially suggesting a microvascular origin of the palsy. Subsequent recurrences of the palsy indicated a different pathophysiologic etiology and MRI revealed the lesion at the petrous apex. Surgical resection improved the compressive effect of the lesion at Dorello's canal and clinical improvement was observed. A relapsing-remitting sixth nerve palsy is an unusual presentation of this rare lesion.

  5. RCC-MX (2008 edition)

    International Nuclear Information System (INIS)

    Bravo, X.; Drubay, B.

    2008-10-01

    The RCC-MX books is a compilation of design and construction rules for the mechanical materials of experimental reactors, for their auxiliaries and irradiation devices. This second edition includes the updates of references to NF, EN and ISO standards, the compliance with the regulations for nuclear pressure equipments, and the feedback since the 2005 edition. It comprises 9 books and a CD-Rom and includes a presentation document. The RCC-MX has been developed for the Jules Horowitz reactor but can be used for the design and construction of new projects of new experimental reactors or new equipments and devices for existing facilities. Content: - Book 1: general dispositions, materials for experimental reactors and their auxiliaries, for irradiation devices and for control or handling mechanisms, complementary requirements and particular dispositions; - Book 2: materials for the reactor and for its level 1 auxiliaries; - Book 3: materials for the reactor and for its level 2 and level 3 auxiliaries, control and handling mechanisms, materials for irradiation devices; - Book 4: technical appendixes - materials characteristics (steels and alloys); - Book 5: technical appendixes (design rules); - Book 6: technical specifications of materials; - Book 7: tests and control methods; - Book 8: welding; - Book 9: fabrication. (J.S.)

  6. Cavernous sinus subarachnoid diverticulum and sixth nerve palsy

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, Tatsuya; Negoro, Makoto; Awaya, Shinobu

    1987-05-01

    Metrizamide CT cisternography in a young woman with a chronic sixth nerve palsy demonstrated a cavernous sinus subarachnoid diverticulum originating from the cerebellopontine cistern. The possible etiologic role of this diverticulum in her palsy is discussed.

  7. Cavernous sinus subarachnoid diverticulum and sixth nerve palsy

    International Nuclear Information System (INIS)

    Kobayashi, Tatsuya; Negoro, Makoto; Awaya, Shinobu

    1987-01-01

    Metrizamide CT cisternography in a young woman with a chronic sixth nerve palsy demonstrated a cavernous sinus subarachnoid diverticulum originating from the cerebellopontine cistern. The possible etiologic role of this diverticulum in her palsy is discussed. (orig.)

  8. Sixth Nerve Palsy in Paediatric Intracranial Hypertension.

    Science.gov (United States)

    Reid, Julia E; Reem, Rachel E; Aylward, Shawn C; Rogers, David L

    2016-02-01

    The purpose of this study was to report the incidence and describe the characteristics of sixth cranial nerve (CN VI) palsy in paediatric patients with intracranial hypertension (IH). A retrospective chart review of central Ohio children diagnosed with IH over the 3-year period from 2010 to 2013 was conducted. IH without identifiable cause was defined as idiopathic intracranial hypertension (IIH), whereas IH with identifiable pathologic aetiology was deemed secondary intracranial hypertension (SIH). A subset of patients with CN VI palsy was identified. Data collected included patient age, gender, past medical history, aetiology of SIH, ophthalmic examination, lumbar puncture results, neuroimaging results, and response to treatment. Seventy-eight children with intracranial hypertension were included in the study. Nine (11.5%) children (four males, five females; median age 14, range: 3-18) were found to have a unilateral ( n = 2) or bilateral ( n = 7) CN VI palsy. Five children had IIH; the remaining four had SIH from cerebral venous sinus thrombosis ( n = 2) and infection ( n = 2). The mean lumbar puncture opening pressure for the nine patients with CN VI palsy was 40 cm H 2 O (range: 21-65 cm H 2 O). Papilloedema was present in 8/9 (89%) patients. One patient required a lumboperitoneal shunt, and two others required optic nerve sheath fenestrations in addition to medical management. All cases of CN VI palsy resolved with treatment. In our primary service area, the incidence of CN VI palsy is approximately 12% among paediatric IH patients. The majority of cases with CN VI palsy presented with papilloedema and all cases resolved with treatment of intracranial hypertension.

  9. CRISPR Genome Editing

    Science.gov (United States)

    A research article about a technique for gene editing known as CRISPR-Cas9. The technique has made it much easier and faster for cancer researchers to study mutations and test new therapeutic targets.

  10. The genome editing revolution

    DEFF Research Database (Denmark)

    Stella, Stefano; Montoya, Guillermo

    2016-01-01

    -Cas system has become the main tool for genome editing in many laboratories. Currently the targeted genome editing technology has been used in many fields and may be a possible approach for human gene therapy. Furthermore, it can also be used to modifying the genomes of model organisms for studying human......In the last 10 years, we have witnessed a blooming of targeted genome editing systems and applications. The area was revolutionized by the discovery and characterization of the transcription activator-like effector proteins, which are easier to engineer to target new DNA sequences than...... sequence). This ribonucleoprotein complex protects bacteria from invading DNAs, and it was adapted to be used in genome editing. The CRISPR ribonucleic acid (RNA) molecule guides to the specific DNA site the Cas9 nuclease to cleave the DNA target. Two years and more than 1000 publications later, the CRISPR...

  11. Non-traumatic sixth nerve palsy in a young patient.

    Science.gov (United States)

    Pilling, R F; Sabri, K; Chaudhuri, P R

    2005-03-01

    Non-traumatic sixth nerve palsy in the 20-50 years old group is unusual and a detailed history is often needed to identify serious and potentially reversible causes. We present a case of sixth sense nerve palsy in a young female with eczema for which she was treated with low-dose cyclosporin. We review the indications for and ocular side effects of cyclosporin, a drug with which most ophthalmologists will be unfamiliar.

  12. Neurosurgery. Fourth edition

    International Nuclear Information System (INIS)

    Simon, L.; Thomas, D.G.T.; Clark, W.K.

    1987-01-01

    The Fourth Edition of this volume in the Operative Surgery Series has been considerably revised to accommodate the many changes which have changed the practice of neurosurgery in the past eight years. There have been advances in technology, such as the wider application of CT scanning, in surgical technique, and in the design of new implantable materials. All these developments have substantially affected both the practice of neurosurgery and the prognosis for the patient and are fully reflected in the new edition

  13. Human Germline Genome Editing

    OpenAIRE

    Ormond, Kelly E.; Mortlock, Douglas P.; Scholes, Derek T.; Bombard, Yvonne; Brody, Lawrence C.; Faucett, W. Andrew; Garrison, Nanibaa’ A.; Hercher, Laura; Isasi, Rosario; Middleton, Anna; Musunuru, Kiran; Shriner, Daniel; Virani, Alice; Young, Caroline E.

    2017-01-01

    With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Gen...

  14. Decimal Classification Editions

    Directory of Open Access Journals (Sweden)

    Zenovia Niculescu

    2009-01-01

    Full Text Available The study approaches the evolution of Dewey Decimal Classification editions from the perspective of updating the terminology, reallocating and expanding the main and auxilary structure of Dewey indexing language. The comparative analysis of DDC editions emphasizes the efficiency of Dewey scheme from the point of view of improving the informational offer, through basic index terms, revised and developed, as well as valuing the auxilary notations.

  15. Developing new levels of edit

    Energy Technology Data Exchange (ETDEWEB)

    Prono, J.K.

    1997-06-01

    Since 1985, Los Alamos National Laboratory (LANL) staff have had four levels of edit to choose from for technical reports. When a CQI survey showed that both authors and editors felt the levels were not meeting author needs, LANL set about revising them. The goals were to simplify the editing process, focus editing on improving technical clarity, and ensure value added in editing. This paper describes the revision process and product--three author-based levels of edit.

  16. Precision genome editing

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Bennett, Eric P; Schjoldager, Katrine Ter-Borch Gram

    2014-01-01

    of glycobiology, primarily due to their low efficiencies, with resultant failure to impose substantial phenotypic consequences upon the final glycosylation products. Here, we review novel nuclease-based precision genome editing techniques enabling efficient and stable gene editing, including gene disruption......Precise and stable gene editing in mammalian cell lines has until recently been hampered by the lack of efficient targeting methods. While different gene silencing strategies have had tremendous impact on many biological fields, they have generally not been applied with wide success in the field...... by introducing single or double-stranded breaks at a defined genomic sequence. We here compare and contrast the different techniques and summarize their current applications, highlighting cases from the field of glycobiology as well as pointing to future opportunities. The emerging potential of precision gene...

  17. Differential diagnosis and management of acquired sixth cranial nerve palsy.

    Science.gov (United States)

    Goodwin, Denise

    2006-11-01

    Cranial nerve VI innervates the lateral rectus muscle. A lesion will result in esotropia greater at distance and an ipsilateral abduction deficiency. After the age of 50 years, vascular diseases are the most commonly known causes. A 55-year-old white man reporting a 2-week history of horizontal diplopia that was worse at distance was found to have a left sixth cranial nerve paresis. The patient was diagnosed with hypertension and placed on medications. At the 4-week follow-up visit, the abduction deficiency had resolved. The incidence of sixth nerve palsy is 11.3 in 100,000. A lesion anywhere along the course of the nerve, from the pons to the orbit, can cause a paresis or palsy. After ruling out trauma and non-neurological problems, cases should be classified into neurologically isolated or non-neurologically isolated cases. Neurologically isolated sixth nerve palsies are associated most commonly with vascular disease. Non-neurologically isolated sixth nerve palsies typically are associated with more grave conditions. A sixth nerve palsy of vascular or undetermined causes typically resolves within 6 to 8 weeks. If resolution does not occur within 2 to 3 months, the condition progresses, or if additional neurologic signs or symptoms develop, imaging studies are indicated.

  18. Human Germline Genome Editing.

    Science.gov (United States)

    Ormond, Kelly E; Mortlock, Douglas P; Scholes, Derek T; Bombard, Yvonne; Brody, Lawrence C; Faucett, W Andrew; Garrison, Nanibaa' A; Hercher, Laura; Isasi, Rosario; Middleton, Anna; Musunuru, Kiran; Shriner, Daniel; Virani, Alice; Young, Caroline E

    2017-08-03

    With CRISPR/Cas9 and other genome-editing technologies, successful somatic and germline genome editing are becoming feasible. To respond, an American Society of Human Genetics (ASHG) workgroup developed this position statement, which was approved by the ASHG Board in March 2017. The workgroup included representatives from the UK Association of Genetic Nurses and Counsellors, Canadian Association of Genetic Counsellors, International Genetic Epidemiology Society, and US National Society of Genetic Counselors. These groups, as well as the American Society for Reproductive Medicine, Asia Pacific Society of Human Genetics, British Society for Genetic Medicine, Human Genetics Society of Australasia, Professional Society of Genetic Counselors in Asia, and Southern African Society for Human Genetics, endorsed the final statement. The statement includes the following positions. (1) At this time, given the nature and number of unanswered scientific, ethical, and policy questions, it is inappropriate to perform germline gene editing that culminates in human pregnancy. (2) Currently, there is no reason to prohibit in vitro germline genome editing on human embryos and gametes, with appropriate oversight and consent from donors, to facilitate research on the possible future clinical applications of gene editing. There should be no prohibition on making public funds available to support this research. (3) Future clinical application of human germline genome editing should not proceed unless, at a minimum, there is (a) a compelling medical rationale, (b) an evidence base that supports its clinical use, (c) an ethical justification, and (d) a transparent public process to solicit and incorporate stakeholder input. Copyright © 2017 American Society of Human Genetics. All rights reserved.

  19. Statics of historic masonry constructions

    CERN Document Server

    Como, Mario

    2016-01-01

    This successful book, which is now appearing in its second edition, presents a comprehensive new Statics of Masonry Constructions. Masonry constructions are the great majority of the buildings in Europe’s historic centres and the most important monuments in its architectural heritage. Given the age of these constructions, the demand for safety assessments and restoration projects is pressing and constant. The book you hold in hands contributes to fill this demand. The second edition integrates the original text of the first edition with new developments, widening and revisions, due to recent research studies achievements. The result is a book that gives a complete picture of the behaviour of the Masonry Constructions. First of all, it gives the fundamentals of its Statics, based on the no-tension assumption, and then it develops the Limit Analysis for the Masonry Constructions. In this framework, through an interdisciplinary approach combining Engineering and Architecture, the book also investigates the sta...

  20. Hybrid layer difference between sixth and seventh generation bonding agent

    Directory of Open Access Journals (Sweden)

    Grace Syavira Suryabrata

    2006-03-01

    Full Text Available Since etching is completed at the same stage as priming and bonding, when applying the sixth and seventh generation bonding, the exposed smear layers are constantly surrounded by primer and bonding and cannot collapse. The smear layer and the depth of penetration of resin bonding in dentinal tubules are completely integrated into hybrid layer. The purpose of this laboratory research was to study the penetration depth of two self etching adhesive. Fourteen samples of human extracted teeth were divided into two groups. Each groups consisted of seven samples, each of them was treated with sixth generation bonding agent and the other was treated with seventh generation bonding agent. The results disclosed that the penetration into dentinal tubules of seventh generation bonding agent was deeper than sixth generation bonding agent. Conclusion: bond strength will improve due to the increasing of penetration depth of resin bonding in dentinal tubules.

  1. Multiple myeloma manifesting as a fluctuating sixth nerve palsy.

    Science.gov (United States)

    Na, Jung Hwa; Park, Shin Hae; Shin, Sun Young

    2009-09-01

    We report a case of multiple myeloma that presented as a fluctuating sixth cranial nerve palsy in the absence of widespread signs of systemic disease. A 63-year-old woman presented with horizontal diplopia of two weeks duration that subjectively changed over time. Ocular examination showed a fluctuating sixth nerve palsy. A computed tomography (CT) scan of the brain showed multiple, enhancing, soft tissue, mass-like lesions involving the left cavernous sinus and the apex of both petrous bones. Based on bone marrow biopsy and hematologic findings, she was diagnosed with multiple myeloma. Multiple myeloma may be included in the differential diagnosis of a fluctuating sixth nerve palsy, and although ophthalmic signs are rare and generally occur late in the course of multiple myeloma, they can still be its first signs.

  2. Editing tools. Transcribing and encoding

    NARCIS (Netherlands)

    Spadini, E.

    2015-01-01

    This paper deals with editing tools and editing platforms, i.e. programs used by editors in order to fulfil one or more tasks in the creation of a scholarly digital edition (SDE). Recurring themes in the field of SDEs are the standardization of XML-TEI markup and the success of documentary digital

  3. Nair handbook. 1995 edition

    International Nuclear Information System (INIS)

    1995-01-01

    This Handbook contains general background, administrative and technical information for those participating in the National Arrangements for Incidents involving Radioactivity (NAIR), updating and replacing the previous edition published in 1987. The overriding need for revision was brought about as a result of changes introduced by British Telecom to the telephone numbers of establishments. (UK)

  4. Beginning to edit physics

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, P.W.

    1995-02-01

    A physicist-turned-editor shows you the basics required for copyediting physics papers (physical quantities, symbols, units, scientific notation, the structure of mathematical expressions, the nature of graphs), and points the way to learning enough ``editorial physics`` to begin substantive editing.

  5. MENTAL DEFICIENCY. SECOND EDITION.

    Science.gov (United States)

    HILLIARD, L.T.; KIRMAN, BRIAN H.

    REVISED TO INCLUDE LEGISLATIVE AND ADMINISTRATIVE PROCEDURES NEW IN BRITAIN SINCE THE 1957 EDITION, THE TEXT INCLUDES RECENT ADVANCES IN ETIOLOGY, PATHOLOGY, AND TREATMENT OF MENTAL DEFICIENCY. CONSIDERATION OF THE BACKGROUND OF MENTAL DEFICIENCY INCLUDES HISTORICAL AND LEGAL ASPECTS, THE SOCIAL BACKGROUND OF MENTAL DEFECT, PRENATAL CAUSES OF…

  6. Newspaper Editing: English, Journalism.

    Science.gov (United States)

    Bullock, Johanna

    A course designed to groom editors for the newspaper is presented. Editing copy, copyreading and proofreading, principles of headlining, responsibility of the press, libel and slander laws, and problems of censorship are covered. Course objectives include the following: (1) The student will recognize and correct all newspaper items that do not…

  7. Black Psychology. Third Edition.

    Science.gov (United States)

    Jones, Reginald L., Ed.

    This book is the third edition of a resource for advanced students and professionals in black psychology in the form of 41 papers organized under 5 subheadings. The "overview" section includes one classic article and offers a new, world view paper. A "perspectives" section treats Afrocentric, humanistic, historical,…

  8. The Craft of Editing

    DEFF Research Database (Denmark)

    Moeran, Brian

    To edit is to make a choice, or series of choices. Will I write a rough draft of this essay in longhand, or hammer it out on my computer? If the latter, what font shall I use? Times New Roman, Book Antiqua, or Garamond? Once I get started, what style shall I adopt: realistic, confessional or impr...

  9. Edit propagation using geometric relationship functions

    KAUST Repository

    Guerrero, Paul

    2014-04-15

    We propose a method for propagating edit operations in 2D vector graphics, based on geometric relationship functions. These functions quantify the geometric relationship of a point to a polygon, such as the distance to the boundary or the direction to the closest corner vertex. The level sets of the relationship functions describe points with the same relationship to a polygon. For a given query point, we first determine a set of relationships to local features, construct all level sets for these relationships, and accumulate them. The maxima of the resulting distribution are points with similar geometric relationships. We show extensions to handle mirror symmetries, and discuss the use of relationship functions as local coordinate systems. Our method can be applied, for example, to interactive floorplan editing, and it is especially useful for large layouts, where individual edits would be cumbersome. We demonstrate populating 2D layouts with tens to hundreds of objects by propagating relatively few edit operations. © 2014 ACM 0730-0301/2014/03- ART15 $15.00.

  10. Tokamaks (Second Edition)

    International Nuclear Information System (INIS)

    Stott, Peter

    1998-01-01

    The first edition of John Wesson's book on tokamaks, published in 1987, established itself as essential reading for researchers in the field of magnetic confinement fusion: it was an excellent introduction for students to tokamak physics and also a valuable reference work for the more experienced. The second edition, published in 1997, has been completely rewritten and substantially enlarged (680 pages compared with 300). The new edition maintains the aim of providing a simple introduction to basic tokamak physics, but also includes discussion of the substantial advances in fusion research during the past decade. The new book, like its predecessor, is well written and commendable for its clarity and accuracy. In fact many of the chapters are written by a series of co-authors bringing the benefits of a wide range of expertise but, by careful editing, Wesson has maintained a uniformity of style and presentation. The chapter headings and coverage for the most part remain the same - but are expanded considerably and brought up to date. The most substantial change is that the single concluding chapter in the first edition on 'Experiments' has been replaced by three chapters: 'Tokamak experiments' which deals with some of the earlier key experiments plus a selection of recent small and medium-sized devices, 'Large experiments' which gives an excellent summary of the main results from the four large tokamaks - TFTR, JET, JT60/JT60U and DIII-D, and 'The future' which gives a very short (possibly too short in my opinion) account of reactors and ITER. This is an excellent book, which I strongly recommend should have a place - on the desk rather than in the bookshelf - of researchers in magnetic confinement fusion. (book review)

  11. A population-based evaluation of the seventh edition of the TNM system for lung cancer

    DEFF Research Database (Denmark)

    Strand, T-E; Rostad, H; Wentzel-Larsen, T

    2010-01-01

    Our study describes the new seventh edition of the TNM system for lung cancer in a national population and its clinical implications. We classified 1,885 operated patients with lung cancer, reported to the Cancer Registry of Norway (Oslo, Norway) from 2001 to 2005, according to the sixth and the ......Our study describes the new seventh edition of the TNM system for lung cancer in a national population and its clinical implications. We classified 1,885 operated patients with lung cancer, reported to the Cancer Registry of Norway (Oslo, Norway) from 2001 to 2005, according to the sixth...... to stage II and 161 (48%) patients migrated from stage IIB to IIA. Stage migrations could change the treatment for up to 326 (17.3%) of the study patients. The seventh edition did not improve the overall predictive ability of the TNM system; however, the new classification implies changes in treatment...... for nearly one-fifth of the cases. The implications of the seventh TNM edition for the outcomes of patients should be studied further....

  12. Sixth annual report of RADMIL 1990/91

    International Nuclear Information System (INIS)

    1991-01-01

    This sixth annual report of RADMIL draws together all parts of the programme of monitoring of radiation and radioactivity in Lancashire from April 1990 to March 1991, including work on radon and intertidal areas, which in previous years has been published separately, and measurements relating to internal exposure from airborne particulates and foodstuffs, i.e. milk, meat, aquatic foods, vegetables etc. (UK)

  13. Eating Attitudes in Fourth-, Sixth-, and Eighth-Grade Girls.

    Science.gov (United States)

    Rhyne-Winkler, Martha C.

    1994-01-01

    Examined eating attitudes of fourth-, sixth-, and eighth-grade girls (n=379) and relationship between those attitudes and achievement scores, school ability, absenteeism, family income, grade level, family size, age, height/weight ratio, diet history, weight satisfaction, appearance satisfaction, and school anxiety. Found that eating-disordered…

  14. Sixth cranial nerve palsy due to arachnoid cyst.

    Science.gov (United States)

    Raveenthiran, Venkatachalam; Reshma, Khajamohideen B

    2014-10-01

    Sixth cranial nerve palsy is an extremely rare complication of an arachnoid cyst. A 4-year-old boy who presented with left abducens palsy and a subdural hygroma complicating arachnoid cyst is discussed. Comprehensive review of the world literature revealed only 12 additional cases. Copyright 2014, SLACK Incorporated.

  15. Sixth ITER technical meeting on safety and environment

    International Nuclear Information System (INIS)

    Saji, G.; Baker, D.

    1997-01-01

    The article summarizes the topics of the Sixth Technical Meeting on Safety and Environment which was held to review the first draft of the Non-Site Specific Safety Report (NSSR-2) and the draft of the ITER Final Design Report Safety Assessment (FDR-Safety) during October 27 - November 4, 1997 at the ITER San Diego Joint Work Site

  16. Proceedings of Sixth National Seminar of Waste Management Technology

    International Nuclear Information System (INIS)

    Sucipta; Zainus Salimin; Lubis, Erwansyah; Herlan Martono; Aisyah; Syahrir; Erini Yuwatini; Thamzil Las; Kusnanto

    2008-06-01

    The sixth proceedings of the seminar on technology of waste management held by National Nuclear Energy Agency on June 24, 2007. The aim of seminar is to increase strengthening of radioactive waste management infrastructure to support a success in nuclear energy program in Indonesia. The proceedings consist of 32 articles from researcher of BATAN and outside BATAN. (PPIKSN)

  17. Proceedings of the Canadian Nuclear Society sixth annual conference

    International Nuclear Information System (INIS)

    French, P.M.; Phillips, G.J.

    1985-01-01

    The proceedings of the Sixth Annual Conference of the Canadian Nuclear Society comprise 103 papers on the following subjects: fuel technology, nuclear plant safety, instrumentation, public and regulatory matters, fusion, fuel behaviour under normal and accident conditions, nuclear plant design and operations, thermal hydraulics, reactor physics, accelerators, waste management, new reactor concepts

  18. Dear Cesar Chavez: Writing Persuasive Letters in the Sixth Grade

    Science.gov (United States)

    Beddow, Maggie

    2012-01-01

    Cesar Chavez, who co-founded the United Farm Workers (UFW) with Dolores Huerta in 1962, dedicated his life to grassroots organizing to persuade lawmakers and the public to help improve the working conditions of migrant farm workers. In October 1992, the author had been teaching a unit of study on civics to her sixth grade bilingual students in…

  19. Achievement Effects of Homework in Sixth Grade Classrooms.

    Science.gov (United States)

    Easton, John Q.; Bennett, Albert

    This study examines the relationship between the amount of time sixth graders reported spending on homework and their achievement gains on the Iowa Test of Basic Skills (ITBS) between the spring of 1988 and the spring of 1989. Selected for participation were one or two classes in each of 30 public elementary schools in Chicago. Of the 30 schools,…

  20. A REVIEW OF THE SIXTH NSUKKA PRINTMAKING WORKSHOP ...

    African Journals Online (AJOL)

    The GeorgeofJudges

    The sixth Nsukka printmaking workshop was a product of such contact, and inspired further linkages for ... have attended the Benin creative programme from the South-Eastern Nigeria, where there was a burgeoning ... the history of art in. Nigeria includes much of how expatriate artists came into the country, how creative-.

  1. Dictionary of minor planet names addendum to 6th edition 2012-2014

    CERN Document Server

    Schmadel, Lutz D

    2015-01-01

    The quantity of numbered minor planets is now approaching half a million. Together with this Addendum, the sixth edition of the Dictionary of Minor Planet Names, which is the IAU's official reference for the field, now covers more than 19,000 named minor planets. In addition to being of practical value for identification purposes, the Dictionary of Minor Planet Names provides authoritative information about the basis for the rich and colorful variety of ingenious names, from heavenly goddesses to artists, from scientists to Nobel laureates, from historical or political figures to ordinary women and men, from mountains to buildings, as well as a variety of compound terms and curiosities. This Addendum to the 6th edition of the Dictionary of Minor Planet Names adds approximately 2200 entries. It also contains many corrections, revisions and updates to the entries published in earlier editions. This work is an abundant source of information for anyone interested in minor planets and who enjoys reading about the ...

  2. Fan edits and the legacy of The Phantom Edit

    Directory of Open Access Journals (Sweden)

    Joshua Wille

    2014-09-01

    Full Text Available A fan edit can generally be defined as an alternative version of a film or television text created by a fan. It offers a different viewing experience, much as a song remix offers a different listening experience. The contemporary wave of fan edits has emerged during the remix zeitgeist of digital media and at a time when digital video editing technology has become more affordable and popular. The increasing number of alternative versions of films and the works of revisionist Hollywood filmmakers such as George Lucas have contributed to a greater public understanding of cinema as a fluid medium instead of one that exists in a fixed form. The Phantom Edit (2000, a seminal fan edit based on Lucas's Star Wars Episode I: The Phantom Menace (1999, inspired new ranks of fan editors. However, critics have misunderstood fan edits as merely the work of disgruntled fans. In order to provide a critical and historical basis for studies in fan editing as a creative practice, I examine previous interpretations of fan edits in the context of relevant contemporary works, and I use an annotated chronology of The Phantom Edit to trace its influence on subsequent fan editing communities and uncover their relationship with intellectual property disputes.

  3. Early Onset Sixth-Nerve Palsy with Eccentric Fixation.

    Science.gov (United States)

    Nanda, Kaajal D; Lacey, Eve; Liasis, Alki; Nischal, Ken K

    2017-01-01

    To report four cases of early onset sixth-nerve palsy all of whom had eccentric fixation. A retrospective case note review was undertaken of all cases presenting to the senior author's private and NHS practice with early onset sixth palsy between 2006 and 2012. As well as demographic information, details of ophthalmic, orthoptic, electrophysiological examinations, and radiological investigations that were extracted from the records. Four children with unilateral or asymmetric early onset sixth-nerve palsy were identified, of which three were congenital. All four had MRI and only one had a normal MRI. Age at presentation ranged from 14-42 months, but all four had marked esotropia and poor visual acuities in the worst affected eye with eccentric fixation, which became more easily or only noticeable after surgical correction. Three patients with congenital sixth-nerve palsy underwent vertical muscle transposition with Botulinum Toxin A (BTXA) to the ipsilateral medial rectus, and two of these patients also had Foster sutures to the transposed vertical muscles. The fourth patient had unilateral medial rectus recession and lateral rectus resection. The mean preoperative measurement was 55 Δ ET (range 50-60 Δ ), and the mean postoperative measurement was 11 Δ ET (range 16XT-25ET) at near, and 2 Δ XT (range 15XT-14ET) at distance. We speculate that early onset paralytic strabismus due to congenital sixth-nerve palsy results in an inability to cross fixate which results in the development of eccentric fixation. Attempts to use reverse occlusion to negate the eccentric fixation failed. We therefore recommend early surgery for this condition to avoid this sequelae. © 2017 Board of regents of the University of Wisconsin System, American Orthoptic Journal, Volume 67, 2017, ISSN 0065-955X, E-ISSN 1553-4448.

  4. Preface to Special Edition

    Directory of Open Access Journals (Sweden)

    Renee Nathanson

    2012-04-01

    Full Text Available Given that reading comprehension is at the forefront of global literacy discourse, this special edition of Per Linguam, the first number that is also published online, features a collection of articles that cover different aspects of reading comprehension and instruction, such as, strategies for comprehending texts, metacognitive awareness, the reciprocity of assessment and comprehension instruction and socio-affective factors that influence comprehension.

  5. UN-EDITED VERSION

    Indian Academy of Sciences (India)

    57

    1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. UN-EDITED VERSION ...

  6. [From random mutagenesis to precise genome editing: the development and evolution of genome editing techniques in Drosophila].

    Science.gov (United States)

    Su, Fang; Huang, Zong-liang; Guo, Ya-wen; Jiao, Ren-jie; Zi, Li; Chen, Jian-ming; Liu, Ji-yong

    2016-01-01

    Drosophila melanogaster, an important model organism for studying life science, has contributed more to the research of genetics, developmental biology and biomedicine with the development of genome editing techniques. Drosophila genome-editing techniques have evolved from random mutagenesis to precise genome editing and from simple mutant construction to diverse genome editing methods since the 20th century. Chemical mutagenesis, using Ethyl methanesulfonate (EMS), is an important technique to study gene function in forward genetics, however, the precise knockout of Drosophila genes could not be achieved. The gene targeting technology, based on homologous recombination, has accomplished the precise editing of Drosophila genome for the first time, but with low efficiency. The CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein)-mediated precise genome editing is simple, fast and highly efficient compared with the gene targeting technology in Drosophila. In this review, we focus on Drosophila gene knockout, and summarize the evolution of genome editing techniques in Drosophila, emphasizing the development and applications of gene targeting, zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and CRISPR/Cas9 techniques.

  7. Building java programs (3rd edition)

    CERN Document Server

    Reges, Stuart

    2013-01-01

    Building Java Programs: A Back to Basics Approach, Third Edition, introduces novice programmers to basic constructs and common pitfalls by emphasizing the essentials of procedural programming, problem solving, and algorithmic reasoning. By using objects early to solve interesting problems and defining objects later in the course, Building Java Programs develops programming knowledge for a broad audience. NEW! This edition is available with MyProgrammingLab, an innovative online homework and assessment tool. Through the power of practice and immediate personalized feedback, MyProgrammingLab helps students fully grasp the logic, semantics, and syntax of programming. Note: If you are purchasing the standalone text or electronic version, MyProgrammingLab does not come automatically packaged with the text. To purchase MyProgrammingLab, please visit: myprogramminglab.com or you can purchase a package of the physical text + MyProgrammingLab by searching the Pearson Higher Education web site. MyProgrammi...

  8. Prospective Mathematics Teachers' Ability to Identify Mistakes Related to Angle Concept of Sixth Grade Students

    Science.gov (United States)

    Arslan, Cigdem; Erbay, Hatice Nur; Guner, Pinar

    2017-01-01

    In the present study we try to highlight prospective mathematics teachers' ability to identify mistakes of sixth grade students related to angle concept. And also we examined prospective mathematics teachers' knowledge of angle concept. Study was carried out with 30 sixth-grade students and 38 prospective mathematics teachers. Sixth grade students…

  9. The Health of the Public Charter School Movement: A State-by-State Analysis. Second Edition

    Science.gov (United States)

    Ziebarth, Todd; Bierlein Palmer, Louann

    2016-01-01

    In October 2014, the first edition of "The Health of the Public Charter School Movement: A State-by-State Analysis" was released. Both encouraging words and constructive criticism for how to improve the report going forward were received. This second edition builds on the solid foundation of the inaugural version, while making…

  10. Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array

    NARCIS (Netherlands)

    Zetsche, Bernd; Heidenreich, Matthias; Mohanraju, Prarthana; Fedorova, Iana; Kneppers, Jeroen; Degennaro, Ellen M.; Winblad, Nerges; Choudhury, Sourav R.; Abudayyeh, Omar O.; Wu, Wen Y.; Oost, van der John

    2017-01-01

    Targeting of multiple genomic loci with Cas9 is limited by the need for multiple or large expression constructs. Here we show that the ability of Cpf1 to process its own CRISPR RNA (crRNA) can be used to simplify multiplexed genome editing. Using a single customized CRISPR array, we edit up to

  11. Revising and editing for translators

    CERN Document Server

    Mossop, Brian

    2014-01-01

    Revising and Editing for Translators provides guidance and learning materials for translation students learning to edit texts written by others, and professional translators wishing to improve their self-revision ability or learning to revise the work of others. Editing is understood as making corrections and improvements to texts, with particular attention to tailoring them to the given readership. Revising is this same task applied to draft translations. The linguistic work of editors and revisers is related to the professional situations in which they work. Mossop offers in-depth coverage of a wide range of topics, including copyediting, style editing, structural editing, checking for consistency, revising procedures and principles, and translation quality assessment. This third edition provides extended coverage of computer aids for revisers, and of the different degrees of revision suited to different texts. The inclusion of suggested activities and exercises, numerous real-world examples, a proposed gra...

  12. Photo Editing: A Neglected Art.

    Science.gov (United States)

    Bergeman, Rich

    1987-01-01

    Offers guidelines for using photographs effectively in campus newspapers. Reviews the stages in the photo editing process, suggests alternatives to traditional photographic approaches, and offers technical advice. (AYC)

  13. REDIdb: the RNA editing database.

    Science.gov (United States)

    Picardi, Ernesto; Regina, Teresa Maria Rosaria; Brennicke, Axel; Quagliariello, Carla

    2007-01-01

    The RNA Editing Database (REDIdb) is an interactive, web-based database created and designed with the aim to allocate RNA editing events such as substitutions, insertions and deletions occurring in a wide range of organisms. The database contains both fully and partially sequenced DNA molecules for which editing information is available either by experimental inspection (in vitro) or by computational detection (in silico). Each record of REDIdb is organized in a specific flat-file containing a description of the main characteristics of the entry, a feature table with the editing events and related details and a sequence zone with both the genomic sequence and the corresponding edited transcript. REDIdb is a relational database in which the browsing and identification of editing sites has been simplified by means of two facilities to either graphically display genomic or cDNA sequences or to show the corresponding alignment. In both cases, all editing sites are highlighted in colour and their relative positions are detailed by mousing over. New editing positions can be directly submitted to REDIdb after a user-specific registration to obtain authorized secure access. This first version of REDIdb database stores 9964 editing events and can be freely queried at http://biologia.unical.it/py_script/search.html.

  14. Genome Editing Tools in Plants

    Directory of Open Access Journals (Sweden)

    Tapan Kumar Mohanta

    2017-12-01

    Full Text Available Genome editing tools have the potential to change the genomic architecture of a genome at precise locations, with desired accuracy. These tools have been efficiently used for trait discovery and for the generation of plants with high crop yields and resistance to biotic and abiotic stresses. Due to complex genomic architecture, it is challenging to edit all of the genes/genomes using a particular genome editing tool. Therefore, to overcome this challenging task, several genome editing tools have been developed to facilitate efficient genome editing. Some of the major genome editing tools used to edit plant genomes are: Homologous recombination (HR, zinc finger nucleases (ZFNs, transcription activator-like effector nucleases (TALENs, pentatricopeptide repeat proteins (PPRs, the CRISPR/Cas9 system, RNA interference (RNAi, cisgenesis, and intragenesis. In addition, site-directed sequence editing and oligonucleotide-directed mutagenesis have the potential to edit the genome at the single-nucleotide level. Recently, adenine base editors (ABEs have been developed to mutate A-T base pairs to G-C base pairs. ABEs use deoxyadeninedeaminase (TadA with catalytically impaired Cas9 nickase to mutate A-T base pairs to G-C base pairs.

  15. A REVIEW ON GENOME EDITING

    OpenAIRE

    Akshay Patil, Latesh Patil, H. P. Suryawanshi, S. P. Pawar

    2017-01-01

    The Present Review report contains the information about Genome Editing. In this report genome editing is illustrated at the basic level for better understanding. It contains History of Genome Editing from 1800 to Current day i.e. from concept of DNA till current time. Genome editing is an technique to make every human smarter not our choice, by customizing next generation the way we want it to be like to be look and also the intellectual capacity. In this Concept, the viral Immunity is used ...

  16. The sixth sense : synaesthesia and British aestheticism, 1860-1900

    OpenAIRE

    Poueymirou, Margaux Lynn Rosa

    2009-01-01

    “The Sixth Sense: Synaesthesia and British Aestheticism 1860-1900” is an interdisciplinary examination of the emergence of synaesthesia conceptually and rhetorically within the ‘art for art’s sake’ movement in mid-to-late Victorian Britain. Chapter One investigates Swinburne’s focal role as both theorist and literary spokesman for the nascent British Aesthetic movement. I argue that Swinburne was the first to practice what Pater meant by ‘aesthetic criticism’ and that synaesthe...

  17. Etiology and treatment of pediatric sixth nerve palsy.

    Science.gov (United States)

    Merino, Pilar; Gómez de Liaño, Pilar; Villalobo, Jose Miguel Caro; Franco, Gema; Gómez de Liaño, Rosario

    2010-12-01

    To describe the causes and treatment of sixth (abducens) nerve palsy in a series of pediatric patients. This was a 14-year retrospective study of sixth nerve palsy in children under 14 years of age. Outcomes studied included horizontal deviation, degree of limitation of abduction, and head turn. Patients were treated with botulinum toxin injection at the time of diagnosis; surgery was indicated if treatment with botulinum toxin was unsuccessful. Success was defined as final deviation of orthotropia with no head turn or diplopia. Sixth nerve palsy was diagnosed in 15 patients (10 boys; mean age, 4.1 years) between 1995 and 2008. Involvement was bilateral in 2 cases and unilateral in 13 (7 right eyes). Causes included neoplasm (4 cases), trauma (2), idiopathic (3), congenital (2), viral (2), and inflammatory (1). Neoplastic causes were associated with other neurologic signs. Recovery was spontaneous in 5 cases (2 idiopathic, 1 traumatic, 1 congenital, and 1 inflammatory). Botulinum toxin was successful in 7 of 10 patients treated, with follow-up surgery required in the remaining 3 cases. The final result was good in all cases. In all 15 patients, mean time from diagnosis to resolution was 39 months (range, 5 to 170 months). Neoplasms were the most frequent cause of sixth nerve palsy in our patient population. Recovery was spontaneous in one third of the patients. Most required treatment with botulinum toxin, which was successful in most cases. Surgery was successful after a single procedure. Copyright © 2010 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.

  18. Isolated sixth nerve palsy after intravitreal ranibizumab injection.

    Science.gov (United States)

    Caglar, Cagatay; Kocamis, Sücattin Ilker; Durmus, Mustafa

    2016-09-01

    After intravitreal ranibizumab injection for diabetic macular edema (DME) in a 55-year-old man, the patient was admitted to our ophthalmology clinic with the complaint of diplopia. Given the results of the patient's history, physical exam, and negative magnetic resonance imaging (MRI), we believed that the patient had a sixth nerve palsy related to ranibizumab injection. To the best of our knowledge, this is the first case with isolated abducens palsy after ranibizumab injection.

  19. Sixth international symposium on mycotoxins and phycotoxins: book of abstracts

    International Nuclear Information System (INIS)

    1985-01-01

    This book contains only the abstracts of seminars that were delivered on the sixth international symposium on mycotoxins and phycotoxins on 22-25 July 1985 in Pretoria under the auspices of the International Union of Pure and Applied Chemistry (IUPAC) and the South African Council for Scientific and Industrial Research. Subject-coverage includes biosynthesis, metabolism, structure and chemical properties, analysis, biochemical mechanisms, toxicity, and pathology of mycotoxins and phycotoxins

  20. Geometric description of a discrete power function associated with the sixth Painlevé equation

    Science.gov (United States)

    Joshi, Nalini; Kajiwara, Kenji; Masuda, Tetsu; Nakazono, Nobutaka; Shi, Yang

    2017-11-01

    In this paper, we consider the discrete power function associated with the sixth Painlevé equation. This function is a special solution of the so-called cross-ratio equation with a similarity constraint. We show in this paper that this system is embedded in a cubic lattice with W ~ (3 A1(1 )) symmetry. By constructing the action of W ~ (3 A1(1 )) as a subgroup of W ~ (D4(1 )), i.e. the symmetry group of PVI, we show how to relate W ~ (D4(1 )) to the symmetry group of the lattice. Moreover, by using translations in W ~ (3 A1(1 )), we explain the odd-even structure appearing in previously known explicit formulae in terms of the τ function.

  1. Proceedings of the Sixth Symposium of the Croatian Radiation Protection Association

    International Nuclear Information System (INIS)

    Garaj-Vrhovac, V.; Kopjar, N.; Miljanic, S.

    2005-01-01

    Croatian Radiation Protection Association (CRPA) organised symposium with international participation. Co-organisers (Rudjer Boskovic Institute, Zagreb, Croatia and Institute for Medical Research and Occupational Health, Zagreb, Croatia) show importance of this symposium, which was under the auspices of several ministries (Ministry of Economy, Labour and Entrepreneurship, Ministry of Environmental Protection, Physical Planning and Construction, Ministry of Science, Education and Sports of the Republic of Croatia) and State Institute of Radiation Protection, State Office for Standardization and Metrology and APO Ltd. - Hazardous Waste Management Agency. All topics are of great interest for Croatia. They present recent researches in Croatia and in other almost same oriented countries in Europe.The distribution of topics at the Sixth symposium shows same parts with articles from radiation dosimetry and instrumentation, biological effects of radiation, public exposure, radiation protection in medicine, as well as radioecology. Also, non-ionising radiations take their share as very interesting topics at present. (S.P.)

  2. Instrumental analysis, second edition

    International Nuclear Information System (INIS)

    Christian, G.D.; O'Reilly, J.E.

    1988-01-01

    The second edition of Instrumental Analysis is a survey of the major instrument-based methods of chemical analysis. It appears to be aimed at undergraduates but would be equally useful in a graduate course. The volume explores all of the classical quantitative methods and contains sections on techniques that usually are not included in a semester course in instrumentation (such as electron spectroscopy and the kinetic methods). Adequate coverage of all of the methods contained in this book would require several semesters of focused study. The 25 chapters were written by different authors, yet the style throughout the book is more uniform than in the earlier edition. With the exception of a two-chapter course in analog and digital circuits, the book purports to de-emphasize instrumentation, focusing more on the theory behind the methods and the application of the methods to analytical problems. However, a detailed analysis of the instruments used in each method is by no means absent. The book has the favor of a user's guide to analysis

  3. Quantitative Seismology, Second Edition

    Science.gov (United States)

    Lay, Thorne

    As recently as 1980, anyone seeking a rigorous treatment of the fundamentals of elastodynamics relevant to the rapidly maturing field of seismology had to delve into a host of primary sources, some of which were rather obscure or difficult to obtain. Classical texts in this field tended to focus on limited topics and to treat some areas either superficially or in excessive depth. Graduate education in the field of seismology tended to reflect local faculty expertise and interests, often with compendia of handwritten notes, inconsistent notation, and variable generality. That situation was dramatically changed with the appearance of the first edition of Quantitative Seismology, a two-volume set that distilled the key foundations of elastodynamics for linear elastic materials into an accessible and satisfyingly thorough presentation of seismological theory. The adoption of a uniform, consistent notation in which many previous contributions were represented was perhaps as great of a contribution to the field as the many conceptual insights revealed by the authors' treatment of the topic. That work has become a disciplinary standard, with tremendous impact on the education of students and the research of advanced practitioners in the field. No subsequent text has supplanted this cornerstone of the discipline, but over time the second volume went out of print and a second edition became necessary.

  4. Natural Hazards, Second Edition

    Science.gov (United States)

    Rouhban, Badaoui

    Natural disaster loss is on the rise, and the vulnerability of the human and physical environment to the violent forces of nature is increasing. In many parts of the world, disasters caused by natural hazards such as earthquakes, floods, landslides, drought, wildfires, intense windstorms, tsunami, and volcanic eruptions have caused the loss of human lives, injury, homelessness, and the destruction of economic and social infrastructure. Over the last few years, there has been an increase in the occurrence, severity, and intensity of disasters, culminating with the devastating tsunami of 26 December 2004 in South East Asia.Natural hazards are often unexpected or uncontrollable natural events of varying magnitude. Understanding their mechanisms and assessing their distribution in time and space are necessary for refining risk mitigation measures. This second edition of Natural Hazards, (following a first edition published in 1991 by Cambridge University Press), written by Edward Bryant, associate dean of science at Wollongong University, Australia, grapples with this crucial issue, aspects of hazard prediction, and other issues. The book presents a comprehensive analysis of different categories of hazards of climatic and geological origin.

  5. With this Special Edition

    Directory of Open Access Journals (Sweden)

    Oscar Antonio Martínez Molina

    2017-02-01

    Full Text Available With this Special Edition, the refereed Scientific Magazine, published in February 2017, presents a nourished and multidisciplinary theme, from the relationship of Environmental Education, in this ecological sharing man-environment; the social responsibility from the Management environment and the motivational values ​​conducive to the teaching performance in the different educational levels. Twenty-five (25 articles, generated from research production in university environments at the International level, are a signature of the quality of articles / essays presented in this Special Edition. Several reasons motivate the literary pen of our authors, adjusting to the rhythm of the times and the use of new technologies; and in correspondence with the care of the environment, this way of disseminating and making visible the scientific contents of humanistic and social court, support the care and protection of the forests, being an online production, in the Cloud. Thanks to the support of the Instituto Internacional de Investigación y Desarrollo Tecnológico Educativo INDTEC, CA, Scientific Magazine has been able to develop from the cooperative work of the people who compose its different committees: Editorial Academic Committee, Academic Scientific Committee and the Arbitrators in the review and valuation of the quality of the articles. With these assets, the Scientific Magazine, opening to the general public and especially to the academic new intellectual horizons.

  6. Unaugmented vertical muscle transposition surgery for chronic sixth nerve paralysis.

    Science.gov (United States)

    Bansal, Shveta; Khan, Javeed; Marsh, Ian B

    2006-12-01

    Chronic sixth nerve palsy can cause incapacitating diplopia requiring vertical muscle transposition surgery. Augmentation of surgery, with lateral fixation sutures, medial rectus recession or botulinum toxin injection, is associated with an increased risk of complications. Our aim was to evaluate the efficacy and safety of unaugmented full-tendon vertical rectus transposition in chronic sixth nerve paralysis. Longitudinal study of 21 patients with chronic sixth nerve paralysis of longer than 6 months duration, who underwent superior and inferior recti transposition surgery without medial rectus recession or botulinum toxin injection. Details of surgery, preoperative and postoperative examinations including full orthoptic examination were obtained from an electronic database. Outcomes included the change in angle of deviation, the requirement for further surgery to the medial rectus and postoperative improvement in diplopia. SPSS software (Version 12.0.1, SPSS Inc. Chicago, IL) was used to summarize baseline characteristics and outcomes and to compare preoperative and postoperative deviation (paired t-test). Twenty-one patients (10 (47.6%) men and 11 (52.4%) women) with a mean age of 41 years (range 4 to 74 years) were operated in the period between April 1998 and November 2000. Eighteen patients had unilateral and three had bilateral acquired sixth nerve palsy. Nineteen patients required unilateral surgery and two had bilateral transposition procedures. In patients with unilateral sixth nerve palsy, mean esotropia in primary position before surgery was 46.7 prism-diopters (PD) (95% CI 35.9-57.4 PD) and improved to 14.6 PD after surgery (95% CI 6.4-22.7 PD). The angle of deviation was significantly reduced by an average of 32.1 PD (p < 0.001, paired t-test; 95% CI 22.6-41.6 PD). Over all, 10 patients (55.6%) had a well-controlled esophoria with a postoperative alignment of within 10 PD of orthophoria without diplopia in the primary position, for distance and near. A

  7. Annotation in Digital Scholarly Editions

    NARCIS (Netherlands)

    Boot, P.; Haentjens Dekker, R.

    2016-01-01

    Annotation in digital scholarly editions (of historical documents, literary works, letters, etc.) has long been recognized as an important desideratum, but has also proven to be an elusive ideal. In so far as annotation functionality is available, it is usually developed for a single edition and

  8. Fundamentals of Welding. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    Science.gov (United States)

    Fortney, Clarence; Gregory, Mike; New, Larry

    Teacher and student editions and a student workbook for fundamentals of welding comprise the first of six in a series of competency-based instructional materials for welding programs. Introductory pages in the teacher edition are training and competency profile, instructional/task analysis, basic skills icons and classifications, basic skills…

  9. Oxyacetylene Welding and Oxyfuel Cutting. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    Science.gov (United States)

    Knapp, John; Harper, Eddie

    This Oklahoma curriculum guide, which includes a teacher edition, a student edition, and a student workbook, provides three units for a course on oxyacetylene welding, oxyfuel cutting, and cutting done with alternative fuels such as MAPP, propane, and natural gas. The three units are: "Oxyacetylene Welding"; "Oxyfuel Cutting";…

  10. Approximating Tree Edit Distance through String Edit Distance

    OpenAIRE

    Akutsu, Tatsuya; Fukagawa, Daiji; Takasu, Atsuhiro

    2010-01-01

    We present an algorithm to approximate edit distance between two ordered and rooted trees of bounded degree. In this algorithm, each input tree is transformed into a string by computing the Euler string, where labels of some edges in the input trees are modified so that structures of small subtrees are reflected to the labels. We show that the edit distance between trees is at least 1/6 and at most O(n 3/4) of the edit distance between the transformed strings, where n is the maximum size of t...

  11. Sixth international conference on electrical machines and drives

    International Nuclear Information System (INIS)

    1993-01-01

    This volume contains 111 papers presented at the Sixth International Conference on Electrical Machines and Drives. The topics covered include: miniature and micro motors; induction motors; DC machines; reluctance motors; condition monitoring; synchronous machines and drives; induction machines; induction generators; simulation; design; and operating experience; linear machines; noise and vibration; special machines. Separate abstracts have been prepared for a paper on linear step motors for control rod drives and for a paper on a motor drive for gas filtration in gas-cooled reactors. (UK)

  12. Has the Earth's sixth mass extinction already arrived?

    Science.gov (United States)

    Barnosky, Anthony D; Matzke, Nicholas; Tomiya, Susumu; Wogan, Guinevere O U; Swartz, Brian; Quental, Tiago B; Marshall, Charles; McGuire, Jenny L; Lindsey, Emily L; Maguire, Kaitlin C; Mersey, Ben; Ferrer, Elizabeth A

    2011-03-03

    Palaeontologists characterize mass extinctions as times when the Earth loses more than three-quarters of its species in a geologically short interval, as has happened only five times in the past 540 million years or so. Biologists now suggest that a sixth mass extinction may be under way, given the known species losses over the past few centuries and millennia. Here we review how differences between fossil and modern data and the addition of recently available palaeontological information influence our understanding of the current extinction crisis. Our results confirm that current extinction rates are higher than would be expected from the fossil record, highlighting the need for effective conservation measures.

  13. Isolated sixth nerve palsy after intravitreal bevacizumab injection.

    Science.gov (United States)

    Cakmak, Hasan Basri; Toklu, Yasin; Yorgun, Mücella Arikan; Simşek, Saban

    2010-03-01

    To report a case of sixth nerve palsy after intravitreal bevacuzimab injection. After intravitreal bevacizumab injection in a 64-year-old man, the patient admitted to our clinic with the complaint of diplopia. A complete ophthalmologic examination was done to clear the symptomatology of patient. Examination of ductions revealed marked limitation of abduction of the right eye and full ductions of the left eye, consistent with right lateral rectus paralysis. Although intravitreal bevacizumab injections are generally well tolerated, it is possible that some serious systemic adverse events may occur. For this reason, patients must be closely monitored following these injections.

  14. [Isolated sixth nerve palsy--presenting sign of multiple myeloma].

    Science.gov (United States)

    Zahavi, Alon; Manor, Riri S; Lahav, Meir; Bakon, Mati; Kalish, Hadas

    2013-02-01

    Multiple myeloma is a disease caused by neoplastic plasma cells. Initial symptoms in most cases described in the literature include chest and lumbar pain, paresthesia, paraplegia, general weakness and renal failure. We report a case of isolated sixth nerve palsy causing diplopia as the presenting sign of multiple myeloma. Awareness of such a rare clinical presentation - especially when the existence of multiple myeloma is ignored after visualization of a cranial mass with magnetic resonance imaging (MRI) and computerized tomography (CT)--can prevent unnecessary surgical intervention and delay the appropriate treatment.

  15. Moments of general Heisenberg Hamiltonians up to sixth order

    OpenAIRE

    Schmidt, Heinz-Juergen; Lohmann, Andre; Richter, Johannes

    2010-01-01

    We explicitly calculate the moments t_n of general Heisenberg Hamiltonians up to sixth order. They have the form of finite sums of products of two factors, the first factor being represented by a multigraph and the second factor being a polynomial in the variable s(s + 1), where s denotes the individual spin quantum number. As an application we determine the corresponding coefficients of the expansion of the free energy and the zero field susceptibility in powers of the inverse temperature. T...

  16. Sixth Grade Student Self-Regulation in Science

    Science.gov (United States)

    Reid, Lisa J.

    The positive relationship between self-regulation and student achievement has been repeatedly supported through research. Key considerations that have resulted from prior research include instructor feedback and explicit expectations, student perception of their control of their progress, accurate self-calibration, reflection, goal-setting, age, and methods by which a cycle which integrates all of these can be put in place. While research provides evidence for that fact that it is possible to support student success in several of these areas, many questions are left as to how guided, active self-regulation impacts students perception of their control over their performance, their ability to accurately assess and act upon their strengths and weaknesses, and, ultimately, their overall progress at different developmental stages. This study intended to provide a better understanding of how guidance in the self-regulation strategies of sixth grade science students can impact their attitudes toward learning. Specifically, this study investigated the question, "What is the effect of active reflection, graphing of grades, and goal setting on sixth-grade students' locus of control and ability to self-regulate?"

  17. Surgical management of chronic complete sixth nerve palsy.

    Science.gov (United States)

    Yurdakul, Nazife Sefi; Ugurlu, Seyda; Maden, Ahmet

    2011-01-01

    to evaluate the results of strabismus surgery in patients with chronic complete sixth nerve palsy. the patients with negative traction test underwent full tendon vertical rectus muscle transposition, whereas the patients with positive traction test had medial rectus recession and transposition surgery. Traction sutures were used in patients with deviations greater than 65 prism diopters (PD) in addition to medial rectus recession. the mean age of 6 female (35.3%) and 11 male (64.7%) patients was 45.1 ± 20.5 years (range: 13 to 80 years). The average preoperative and postoperative deviations at the primary position were 64.1 ± 14.3 PD (range: 45 to 85 PD) and 9.6 ± 17.6 PD (range: 0 to 75 PD), respectively, with an overall success rate of 76.5%. most of the patients with chronic sixth nerve palsy could achieve good ocular alignment with a surgical approach that is tailored according to the needs of the individual patient.

  18. Mongolia; Fifth and Sixth Reviews under the Stand-By Arrangement and Rephasing of Purchases

    OpenAIRE

    International Monetary Fund

    2010-01-01

    Despite the negative impact of the severe winter on agriculture, other indicators are pointing to a strong recovery. Exports are growing rapidly, fueled by the rebound in copper prices and a rapid growth in coal exports. Rephasing of purchases by combining the fifth and sixth reviews is requested owing to the delay in completing the fifth review, and earlier-than-planned Board discussion of the sixth review. The sixth review is the final review. The fiscal responsibility law will help secure ...

  19. Biological Science: An Ecological Approach. BSCS Green Version. Teacher's Resource Book and Test Item Bank. Sixth Edition.

    Science.gov (United States)

    Biological Sciences Curriculum Study, Colorado Springs.

    This book consists of four sections: (1) "Supplemental Materials"; (2) "Supplemental Investigations"; (3) "Test Item Bank"; and (4) "Blackline Masters." The first section provides additional background material related to selected chapters and investigations in the student book. Included are a periodic table of the elements, genetics problems and…

  20. Acute sixth nerve palsy in a young man, beware of the 'red herring'.

    LENUS (Irish Health Repository)

    O'Neill, E C

    2012-02-01

    BACKGROUND: Cranial nerve palsies has several etiologies including vascular insufficiency, neoplasm, trauma and inflammation. Isolated sixth nerve palsy is an extremely rare presenting feature of leukemia. AIM: We describe an unusual ocular presentation of a bilateral progressive sixth nerve palsy in a young male with a preceding head injury. CONCLUSION: Acquired sixth nerve palsies in young adults may be due to trauma but in the absence of a definitive history other systemic processes must be outruled. We describe a case of bilateral sixth nerve palsy in a patient with ALL with no obvious CNS involvement. Potential etiological mechanisms are discussed.

  1. Bevacizumab-induced transient sixth nerve palsy in ovarian cancer: A case report.

    Science.gov (United States)

    Momeni, Mazdak; Veras, Laura; Zakashansky, Konstantin

    2016-03-01

    We report a case of transient sixth nerve palsy after systemic administration of bevacizumab. Two days after systemic administration of bevacizumab in conjunction with gemcitabine and carboplatin in a 67-year-old woman with recurrent primary ovarian cancer, the patient developed sixth nerve palsy. After bevacizumab was stopped, the complete left sixth nerve palsy resolved spontaneously over the course of 3 months. This is the first reported case of bevacizumab-induced cranial sixth nerve palsy in the treatment of gynecologic malignancy. © 2013 Wiley Publishing Asia Pty Ltd.

  2. Acute sixth nerve palsy in a young man, beware of the 'red herring'.

    Science.gov (United States)

    O'Neill, E C; Connell, P P; Kadare, S; Tormey, P T

    2010-06-01

    Cranial nerve palsies has several etiologies including vascular insufficiency, neoplasm, trauma and inflammation. Isolated sixth nerve palsy is an extremely rare presenting feature of leukemia. We describe an unusual ocular presentation of a bilateral progressive sixth nerve palsy in a young male with a preceding head injury. Acquired sixth nerve palsies in young adults may be due to trauma but in the absence of a definitive history other systemic processes must be outruled. We describe a case of bilateral sixth nerve palsy in a patient with ALL with no obvious CNS involvement. Potential etiological mechanisms are discussed.

  3. [Preface for genome editing special issue].

    Science.gov (United States)

    Gu, Feng; Gao, Caixia

    2017-10-25

    Genome editing technology, as an innovative biotechnology, has been widely used for editing the genome from model organisms, animals, plants and microbes. CRISPR/Cas9-based genome editing technology shows its great value and potential in the dissection of functional genomics, improved breeding and genetic disease treatment. In the present special issue, the principle and application of genome editing techniques has been summarized. The advantages and disadvantages of the current genome editing technology and future prospects would also be highlighted.

  4. Marine botany. Second edition

    Energy Technology Data Exchange (ETDEWEB)

    Dawes, C.J. [Univ. of South Florida, Tampa, FL (United States)

    1998-12-01

    Marine plants are a diverse group that include unicellular algae, seaweeds, seagrasses, salt marshes, and mangrove forests. They carry out a variety of ecological functions and serve as the primary producers in coastal wetlands and oceanic waters. The theme that connects such a wide variety of plants is their ecology, which was also emphasized in the 1981 edition. The goal of this revision is to present taxonomic, physiological, chemical, and ecological aspects of marine plants, their adaptations, and how abiotic and biotic factors interact in their communities. The data are presented in a concise, comparative manner in order to identify similarities and differences between communities such as salt marsh and mangroves or subtidal seaweeds and seagrasses. To accomplish this, the text is organized into five chapters that introduce the marine habitats, consider abiotic and biotic factors, and anthropogenic influences on the communities followed by seven chapters that deal with microalgae, seaweeds, salt marshes, mangroves, seagrasses, and coral reefs. Two appendixes are included; one presents simple field techniques and the other is a summary of seaweed uses.

  5. A General Framework for Edited Video and Raw Video Summarization.

    Science.gov (United States)

    Li, Xuelong; Zhao, Bin; Lu, Xiaoqiang

    2017-08-01

    In this paper, we build a general summarization framework for both of edited video and raw video summarization. Overall, our work can be divided into three folds. 1) Four models are designed to capture the properties of video summaries, i.e., containing important people and objects (importance), representative to the video content (representativeness), no similar key-shots (diversity), and smoothness of the storyline (storyness). Specifically, these models are applicable to both edited videos and raw videos. 2) A comprehensive score function is built with the weighted combination of the aforementioned four models. Note that the weights of the four models in the score function, denoted as property-weight, are learned in a supervised manner. Besides, the property-weights are learned for edited videos and raw videos, respectively. 3) The training set is constructed with both edited videos and raw videos in order to make up the lack of training data. Particularly, each training video is equipped with a pair of mixing-coefficients, which can reduce the structure mess in the training set caused by the rough mixture. We test our framework on three data sets, including edited videos, short raw videos, and long raw videos. Experimental results have verified the effectiveness of the proposed framework.

  6. Genome editing in cardiovascular diseases.

    Science.gov (United States)

    Strong, Alanna; Musunuru, Kiran

    2017-01-01

    Genome-editing tools, which include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) systems, have emerged as an invaluable technology to achieve somatic and germline genomic manipulation in cells and model organisms for multiple applications, including the creation of knockout alleles, introducing desired mutations into genomic DNA, and inserting novel transgenes. Genome editing is being rapidly adopted into all fields of biomedical research, including the cardiovascular field, where it has facilitated a greater understanding of lipid metabolism, electrophysiology, cardiomyopathies, and other cardiovascular disorders, has helped to create a wider variety of cellular and animal models, and has opened the door to a new class of therapies. In this Review, we discuss the applications of genome-editing technology throughout cardiovascular disease research and the prospect of in vivo genome-editing therapies in the future. We also describe some of the existing limitations of genome-editing tools that will need to be addressed if cardiovascular genome editing is to achieve its full scientific and therapeutic potential.

  7. To edit or not to edit: regulation of ADAR editing specificity and efficiency.

    Science.gov (United States)

    Deffit, Sarah N; Hundley, Heather A

    2016-01-01

    Hundreds to millions of adenosine (A)-to-inosine (I) modifications are present in eukaryotic transcriptomes and play an essential role in the creation of proteomic and phenotypic diversity. As adenosine and inosine have different base-pairing properties, the functional consequences of these modifications or 'edits' include altering coding potential, splicing, and miRNA-mediated gene silencing of transcripts. However, rather than serving as a static control of gene expression, A-to-I editing provides a means to dynamically rewire the genetic code during development and in a cell-type specific manner. Interestingly, during normal development, in specific cells, and in both neuropathological diseases and cancers, the extent of RNA editing does not directly correlate with levels of the substrate mRNA or the adenosine deaminase that act on RNA (ADAR) editing enzymes, implying that cellular factors are required for spatiotemporal regulation of A-to-I editing. The factors that affect the specificity and extent of ADAR activity have been thoroughly dissected in vitro. Yet, we still lack a complete understanding of how specific ADAR family members can selectively deaminate certain adenosines while others cannot. Additionally, in the cellular environment, ADAR specificity and editing efficiency is likely to be influenced by cellular factors, which is currently an area of intense investigation. Data from many groups have suggested two main mechanisms for controlling A-to-I editing in the cell: (1) regulating ADAR accessibility to target RNAs and (2) protein-protein interactions that directly alter ADAR enzymatic activity. Recent studies suggest cis- and trans-acting RNA elements, heterodimerization and RNA-binding proteins play important roles in regulating RNA editing levels in vivo. WIREs RNA 2016, 7:113-127. doi: 10.1002/wrna.1319. © 2015 Wiley Periodicals, Inc.

  8. Identifying features in biological sequences: Sixth workshop report

    Energy Technology Data Exchange (ETDEWEB)

    Burks, C. [Los Alamos National Lab., NM (United States); Myers, E. [Univ. of Arizona (United States); Pearson, W.R. [Univ. of Virginia (United States)

    1995-12-31

    This report covers the sixth of an annual series of workshops held at the Aspen Center for Physics concentrating particularly on the identification of features in DNA sequence, and more broadly on related topics in computational molecular biology. The workshop series originally focused primarily on discussion of current needs and future strategies for identifying and predicting the presence of complex functional units on sequenced, but otherwise uncharacterized, genomic DNA. We addressed the need for computationally-based, automatic tools for synthesizing available data about individual consensus sequences and local compositional patterns into the composite objects (e.g., genes) that are -- as composite entities -- the true object of interest when scanning DNA sequences. The workshop was structured to promote sustained informal contact and exchange of expertise between molecular biologists, computer scientists, and mathematicians.

  9. ICENES '91:Sixth international conference on emerging nuclear energy systems

    International Nuclear Information System (INIS)

    1991-01-01

    This document contains the program and abstracts of the sessions at the Sixth International Conference on Emerging Nuclear Energy Systems held June 16--21, 1991 at Monterey, California. These sessions included: The plenary session, fission session, fission and nonelectric session, poster session 1P; (space propulsion, space nuclear power, electrostatic confined fusion, fusion miscellaneous, inertial confinement fusion, μ-catalyzed fusion, and cold fusion); Advanced fusion session, space nuclear session, poster session 2P, (nuclear reactions/data, isotope separation, direct energy conversion and exotic concepts, fusion-fission hybrids, nuclear desalting, accelerator waste-transmutation, and fusion-based chemical recycling); energy policy session, poster session 3P (energy policy, magnetic fusion reactors, fission reactors, magnetically insulated inertial fusion, and nuclear explosives for power generation); exotic energy storage and conversion session; and exotic energy storage and conversion; review and closing session

  10. The Sixth Copper Mountain Conference on Multigrid Methods, part 1

    Science.gov (United States)

    Melson, N. Duane (Editor); Manteuffel, T. A. (Editor); Mccormick, S. F. (Editor)

    1993-01-01

    The Sixth Copper Mountain Conference on Multigrid Methods was held on 4-9 Apr. 1993, at Copper Mountain, CO. This book is a collection of many of the papers presented at the conference and as such represents the conference proceedings. NASA LaRC graciously provided printing of this document so that all of the papers could be presented in a single forum. Each paper was reviewed by a member of the conference organizing committee under the coordination of the editors. The multigrid discipline continues to expand and mature, as is evident from these proceedings. The vibrancy in this field is amply expressed in these important papers, and the collection clearly shows its rapid trend to further diversity and depth.

  11. The Sixth Copper Mountain Conference on Multigrid Methods, part 2

    Science.gov (United States)

    Melson, N. Duane (Editor); Mccormick, Steve F. (Editor); Manteuffel, Thomas A. (Editor)

    1993-01-01

    The Sixth Copper Mountain Conference on Multigrid Methods was held on April 4-9, 1993, at Copper Mountain, Colorado. This book is a collection of many of the papers presented at the conference and so represents the conference proceedings. NASA Langley graciously provided printing of this document so that all of the papers could be presented in a single forum. Each paper was reviewed by a member of the conference organizing committee under the coordination of the editors. The multigrid discipline continues to expand and mature, as is evident from these proceedings. The vibrancy in this field is amply expressed in these important papers, and the collection clearly shows its rapid trend to further diversity and depth.

  12. Sixth Microgravity Fluid Physics and Transport Phenomena Conference Abstracts

    Science.gov (United States)

    Singh, Bhim (Compiler)

    2002-01-01

    The Sixth Microgravity Fluid Physics and Transport Phenomena Conference provides the scientific community the opportunity to view the current scope of the Microgravity Fluid Physics and Transport Phenomena Program, current research opportunities, and plans for the near future. The conference focuses not only on fundamental research but also on applications of this knowledge towards enabling future space exploration missions. A whole session dedicated to biological fluid physics shows increased emphasis that the program has placed on interdisciplinary research. The conference includes invited plenary talks, technical paper presentations, poster presentations, and exhibits. This TM is a compilation of abstracts of the papers and the posters presented at the conference. Web-based proceedings, including the charts used by the presenters, will be posted on the web shortly after the conference.

  13. A report from the Sixth International Mouse Genome Conference

    Energy Technology Data Exchange (ETDEWEB)

    Brown, S. [Saint Mary`s Hospital Medical School, London (United Kingdom). Dept. of Biochemistry and Molecular Genetics

    1992-12-31

    The Sixth Annual Mouse Genome Conference was held in October, 1992 at Buffalo, USA. The mouse is one of the primary model organisms in the Human Genome Project. Through the use of gene targeting studies the mouse has become a powerful biological model for the study of gene function and, in addition, the comparison of the many homologous mutations identified in human and mouse have widened our understanding of the biology of these two organisms. A primary goal in the mouse genome program has been to create a genetic map of STSs of high resolution (<1cM) that would form the basis for the physical mapping of the whole mouse genome. Buffalo saw substantial new progress towards the goal of a very high density genetic map and the beginnings of substantive efforts towards physical mapping in chromosome regions with a high density of genetic markers.

  14. Unilateral Sixth Cranial Nerve Palsy Following C/S as a Complication of Spinal Anaesthesia.

    Science.gov (United States)

    Adaklı, Barış; Özgencil, Enver; Özünlü, Gülen Nevin; Aybar, Refiye Selin; Uysalel, Asuman

    2014-06-01

    Cranial nerve palsy (CNP) is a rare complication following lumbar puncture, which is a common procedure used most often for diagnostic and anaesthetic purposes. The sixth cranial (abducens) nerve is the most commonly affected cranial nerve. We report a case of unilateral sixth nerve palsy after spinal anaesthesia that improved immediately after an epidural blood patch (EBP).

  15. Factors Influencing Mathematic Problem-Solving Ability of Sixth Grade Students

    Science.gov (United States)

    Pimta, Sakorn; Tayraukham, Sombat; Nuangchalerm, Prasart

    2009-01-01

    Problem statement: This study aims to investigate factors influencing mathematic problem-solving ability of sixth grade students. One thousand and twenty eight of sixth grade students, studying in the second semester of academic year 2007 were sampled by stratified random sampling technique. Approach: The research instruments used in the study…

  16. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-01

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed high-level operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques.

  17. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-12

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed highlevel operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques. © 2011 ACM.

  18. Bridge engineering handbook construction and maintenance

    CERN Document Server

    Chen, Wai-Fah

    2014-01-01

    Over 140 experts, 14 countries, and 89 chapters are represented in the second edition of the Bridge Engineering Handbook. This extensive collection highlights bridge engineering specimens from around the world, contains detailed information on bridge engineering, and thoroughly explains the concepts and practical applications surrounding the subject.Published in five books: Fundamentals, Superstructure Design, Substructure Design, Seismic Design, and Construction and Maintenance, this new edition provides numerous worked-out examples that give readers step-by-step design procedures, includes c

  19. Interactive Editing of Live Visuals

    Science.gov (United States)

    Müller, Pascal; Müller Arisona, Stefan; Schubiger-Banz, Simon; Specht, Matthias

    This paper describes novel concepts for the interactive composition of artistic real-time graphics, so-called live visuals. By establishing two fundamental techniques dealing with the structured media integration and the intrinsic design process, we significantly increase the efficiency of interactive editing in live visuals applications. First, we present a media manager that supports the user in both retrieval and utilization of automatically annotated digital media. The computer-assisted application of individual media items permits the interactive control of non-linear editing (NLE) of video in real-time. Second, we optimize the design process by introducing the design tree, which collects and organizes the artist's work in an intuitive way. Design tree operations provide interactive high-level editing methods which allow for exploration, combination, reuse, and evolution of designs before and particularly during the performance. We examined the effectiveness of our techniques on numerous long-lasting live performances from which representative examples are demonstrated.

  20. Boneless Pose Editing and Animation

    DEFF Research Database (Denmark)

    Bærentzen, Jakob Andreas; Hansen, Kristian Evers; Erleben, Kenny

    2007-01-01

    In this paper, we propose a pose editing and animation method for triangulated surfaces based on a user controlled partitioning of the model into deformable parts and rigid parts which are denoted handles. In our pose editing system, the user can sculpt a set of poses simply by transforming...... the handles for each pose. Using Laplacian editing, the deformable parts are deformed to match the handles. In our animation system the user can constrain one or several handles in order to define a new pose. New poses are interpolated from the examples poses, by solving a small non-linear optimization...... problem in order to obtain the interpolation weights. While the system can be used simply for building poses, it is also an animation system. The user can specify a path for a given constraint and the model is animated correspondingly....

  1. Editörden

    Directory of Open Access Journals (Sweden)

    Nadir Arıcan

    2007-04-01

    Full Text Available Değerli Adli Bilimci’ler, Dergimizin ilk baskısının yapıldığı 1996 yılından 2006 yılı sonuna kadar 11 ciltten oluşan dizisini ara vermeden kesintisiz olarak yayınlanma başarısını gösteren Adli Tıp Bülteni Yayın Kurulu adına saygı ile selamlıyoruz. Dergimizin 12. cildinin ilk sayısı, yayın kurulundaki görev değişikliği ile elinize ulaşıyor. “Adli Tıp Bülteni”ni tüm olumsuz koşullara karşın, siz alana emek veren adli bilimcilerin de büyük desteği ile yayın hayatım başarı ile sürdürdü. Bu başarıda başta editörlerimiz sayın Prof. Dr. Serpil Salaçin ve sayın Prof. Dr. Şebnem Korur Fincancı ile yayın kurulunda görev almış meslektaşlarımıza teşekkür ediyor ve desteklerinin artarak devam edeceğini ümit ediyoruz. Adli Tıp Bülteni, ilk editörü sayın Prof. Dr. Serpil Salaçin’in bültenin 1. sayısında belirttiği amaca uygun olarak, her geçen gün daha da güçlenerek yayın hayatını sürdürmektedir. Yayın akışında zaman zaman kesintiler olsa da, amacı doğrultusunda “alanındaki bilgi akışını sağlama ve bilimsel gelişmelerin önemli bir parçası olma özelliğini” Adli Tıp Uzmanları Derneği’nin resmi bilimsel yayın organı kimliği ile devam ettirmektedir. Hedefleri doğrultusunda uluslararası indekslerce taranan bir dergi olma yolunda ilk adımını atan dergimizin bu alandaki çalışmaları sayın Prof. Dr. Şebnem Korur Fincancı tarafından yürütülmektedir. Görevini genç meslektaşına devretmiş olsa da alanımızdaki uluslar arası deneyimi ile Adli Tıp Bülteni’ni çok farklı noktalara taşıyacağı inancındayım. Bu alanda yapacağı katkılardan dolayı sayın hocama biz kez daha teşekkür etmek istiyorum. Bundan böyle Adli Tıp Bülteni’ne yayınlanmak üzere gönderdiğiniz çalışmalarınızın değerlendirmesini daha hızlı yapabilmek ve baskı aşamasına getirmek amacı ile iletişimi elektronik ortamda yapmaya

  2. Tokamaks - Third Edition

    International Nuclear Information System (INIS)

    Rogister, A L

    2004-01-01

    John Wesson's well known book, now re-edited for the third time, provides an excellent introduction to fusion oriented plasma physics in tokamaks. The author's task was a very challenging one, for a confined plasma is a complex system characterised by a variety of dimensionless parameters and its properties change qualitatively when certain threshold values are reached in this multi-parameter space. As a consequence, theoretical description is required at different levels, which are complementary: particle orbits, kinetic and fluid descriptions, but also intuitive and empirical approaches. Theory must be carried out on many fronts: equilibrium, instabilities, heating, transport etc. Since the properties of the confined plasma depend on the boundary conditions, the physics of plasmas along open magnetic field lines and plasma surface interaction processes must also be accounted for. Those subjects (and others) are discussed in depth in chapters 2-9. Chapter 1 mostly deals with ignition requirements and the tokamak concept, while chapter 14 provides a list of useful relations: differential operators, collision times, characteristic lengths and frequencies, expressions for the neoclassical resistivity and heat conduction, the bootstrap current etc. The presentation is sufficiently broad and thorough that specialists within tokamak research can either pick useful and up-to-date information or find an authoritative introduction into other areas of the subject. It is also clear and concise so that it should provide an attractive and accurate initiation for those wishing to enter the field and for outsiders who would like to understand the concepts and be informed about the goals and challenges on the horizon. Validation of theoretical models requires adequately resolved experimental data for the various equilibrium profiles (clearly a challenge in the vicinity of transport barriers) and the fluctuations to which instabilities give rise. Chapter 10 is therefore devoted to

  3. Invitation to number theory second edition

    CERN Document Server

    Ore, Oystein

    2017-01-01

    Number theory is the branch of mathematics concerned with the counting numbers, 1, 2, 3, … and their multiples and factors. Of particular importance are odd and even numbers, squares and cubes, and prime numbers. But in spite of their simplicity, you will meet a multitude of topics in this book: magic squares, cryptarithms, finding the day of the week for a given date, constructing regular polygons, pythagorean triples, and many more. In this revised edition, John Watkins and Robin Wilson have updated the text to bring it in line with contemporary developments. They have added new material on Fermat's Last Theorem, the role of computers in number theory, and the use of number theory in cryptography, and have made numerous minor changes in the presentation and layout of the text and the exercises.

  4. Understanding Editing Behaviors in Multilingual Wikipedia.

    Science.gov (United States)

    Kim, Suin; Park, Sungjoon; Hale, Scott A; Kim, Sooyoung; Byun, Jeongmin; Oh, Alice H

    2016-01-01

    Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary) languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language.

  5. Understanding Editing Behaviors in Multilingual Wikipedia.

    Directory of Open Access Journals (Sweden)

    Suin Kim

    Full Text Available Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language.

  6. Dictionary of Minor Planet Names Addendum to Fifth Edition: 2006 - 2008

    CERN Document Server

    Schmadel, Lutz

    2009-01-01

    The second Addendum to the Dictionary of Minor Planet Names, fifth edition, which is the IAU's official reference for the field, contains all newly published names from the period 2006-2008 as well as corrections and amendments to earlier editions. In total the Dictionary of Minor Planet Names now covers some 15000 named minor planets. It provides authoritative information about the basis for the rich and colorful variety of ingenious names, from heavenly goddesses to more prosaic constructions.

  7. Design and safety features of commercial nuclear power plants in Japan, 1976 edition

    International Nuclear Information System (INIS)

    Izumi, Fumio; Harayama, Yasuo

    1976-10-01

    The December 1975 edition (JAERI-M 5959) contained design particulars and safety features of 20 commercial nuclear power plants in Japan as of December 1974. Subsequently new plants have been put into operation and some plants under construction have undergone design modifications. The present edition presents similar data of the commercial nuclear power plants in Japan up to June 1976, compiled by computer processing. (auth.)

  8. Medical writing, revising and editing

    DEFF Research Database (Denmark)

    Pilegaard, Morten

    2006-01-01

    The globalization of science makes medical writing, editing and revision a rapidly growing field of linguistic study and practice. Medical science texts are written according to uniform, general guidelines and medical genres have become highly conventionalized in terms of structure and linguistic...... form. Medical editing often takes the form of peer review and mainly addresses issues of contents and overall validity. Medical revision incorporates the checking of the macrostructure and the microstructure of the text, its language and style and its suitability for the target reader or client...

  9. Handbook of ecotoxicology, second edition

    Science.gov (United States)

    Hoffman, David J.; Rattner, Barnett A.; Burton, G. Allen; Cairns, John

    2003-01-01

    Handbook of Ecotoxicology, Second Edition focuses on toxic substances and how they affect ecosystems worldwide. It presents methods for quantifying and measuring ecotoxicological effects in the field and in the lab, as well as methods for estimating, predicting, and modeling in ecotoxicology studies. Completely revised and updated with 18 new chapters, this second edition includes contributions from over 75 international experts. Also, a Technical Review Board reviewed all manuscripts for accuracy and currency. This authoritative work is the definitive reference for students, researchers, consultants, and other professionals in the environmental sciences, toxicology, chemistry, biology, and ecology - in academia, industry, and government.

  10. Beginning XML, 5th Edition

    CERN Document Server

    Fawcett, Joe; Quin, Liam R E

    2012-01-01

    A complete update covering the many advances to the XML language The XML language has become the standard for writing documents on the Internet and is constantly improving and evolving. This new edition covers all the many new XML-based technologies that have appeared since the previous edition four years ago, providing you with an up-to-date introductory guide and reference. Packed with real-world code examples, best practices, and in-depth coverage of the most important and relevant topics, this authoritative resource explores both the advantages and disadvantages of XML and addresses the mo

  11. Introducing ZBrush 3rd Edition

    CERN Document Server

    Keller, Eric

    2012-01-01

    Learn ZBrush inside and out with this updated new edition Get totally comfortable sculpting in a digital environment with the latest edition of this bestselling beginner's guide to ZBrush. Fully updated for the newest version of the software, ZBrush 4R3, this book dispels any fears you might have about the difficulty of using ZBrush and soon has you creating realistic, cartoon, and organic models with flair. Learn all the essentials, as you complete fun tutorials on painting, meshes, organic scripting, hard surface sculpting, lighting, rendering, and more. Introduces you to ZBrush, the sculpt

  12. Language Editing at Astronomy & Astrophysics

    Science.gov (United States)

    Adams, J.

    2011-07-01

    In 2002, the A&A Board of Directors voted that all articles must be written in English and decided to improve the overall quality of the language in the articles with the help of a team of language editors. This article reviews the general advantages of editing the English expression and describes both the aims of this effort and its place in the full publication process. This is followed by the Guide to language editing that has been available on the Journal's website for several years now.

  13. Genome editing comes of age.

    Science.gov (United States)

    Kim, Jin-Soo

    2016-09-01

    Genome editing harnesses programmable nucleases to cut and paste genetic information in a targeted manner in living cells and organisms. Here, I review the development of programmable nucleases, including zinc finger nucleases (ZFNs), TAL (transcription-activator-like) effector nucleases (TALENs) and CRISPR (cluster of regularly interspaced palindromic repeats)-Cas9 (CRISPR-associated protein 9) RNA-guided endonucleases (RGENs). I specifically highlight the key advances that set the foundation for the rapid and widespread implementation of CRISPR-Cas9 genome editing approaches that has revolutionized the field.

  14. Shielded Metal Arc Pipe Welding. Teacher Edition. Second Edition.

    Science.gov (United States)

    Fortney, Clarence; And Others

    This second edition of the shielded metal arc pipe welding curriculum guide presents both basic and advanced pipe welding skills. All specifications for procedure and welder qualification are presented according to national standards. The standards also include the test position for both groove and fillet pipe welding. The guide contains three…

  15. Editing Dialogics: Ethical Issues Concerning Student Contributors in Edited Collections.

    Science.gov (United States)

    Tassoni, John Paul; Tayko, Gail

    2003-01-01

    Discusses the authors' attempts to enact a process they have come to call "editing dialogics" and its relation to the Conference on College Composition and Communication's "Guidelines for the Ethical Treatment of Students and Student Writing in Composition Studies." Makes their roles explicit to expose elements of scholarly…

  16. Gas Tungsten Arc Welding and Plasma Arc Cutting. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    Science.gov (United States)

    Harper, Eddie; Knapp, John

    This packet of instructional materials for a gas tungsten arc welding (GTAW) and plasma arc cutting course is comprised of a teacher edition, student edition, and student workbook. The teacher edition consists of introductory pages and teacher pages. Introductory pages include training and competency profile, state duty/task crosswalk,…

  17. Gas Metal Arc Welding and Flux-Cored Arc Welding. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    Science.gov (United States)

    Knapp, John; Harper, Eddie

    This packet, containing a teacher's edition, a student edition, and a student workbook, introduces students to high deposition welding and processes for "shielding" a weld. In addition to general information, the teacher edition consists of introductory pages and teacher pages, as well as unit information that corresponds to the…

  18. Mojo Hand, a TALEN design tool for genome editing applications

    Directory of Open Access Journals (Sweden)

    Neff Kevin L

    2013-01-01

    Full Text Available Abstract Background Recent studies of transcription activator-like (TAL effector domains fused to nucleases (TALENs demonstrate enormous potential for genome editing. Effective design of TALENs requires a combination of selecting appropriate genetic features, finding pairs of binding sites based on a consensus sequence, and, in some cases, identifying endogenous restriction sites for downstream molecular genetic applications. Results We present the web-based program Mojo Hand for designing TAL and TALEN constructs for genome editing applications (http://www.talendesign.org. We describe the algorithm and its implementation. The features of Mojo Hand include (1 automatic download of genomic data from the National Center for Biotechnology Information, (2 analysis of any DNA sequence to reveal pairs of binding sites based on a user-defined template, (3 selection of restriction-enzyme recognition sites in the spacer between the TAL monomer binding sites including options for the selection of restriction enzyme suppliers, and (4 output files designed for subsequent TALEN construction using the Golden Gate assembly method. Conclusions Mojo Hand enables the rapid identification of TAL binding sites for use in TALEN design. The assembly of TALEN constructs, is also simplified by using the TAL-site prediction program in conjunction with a spreadsheet management aid of reagent concentrations and TALEN formulation. Mojo Hand enables scientists to more rapidly deploy TALENs for genome editing applications.

  19. RNA editing machinery in plant organelles.

    Science.gov (United States)

    Yan, Junjie; Zhang, Qunxia; Yin, Ping

    2018-02-01

    RNA editing is a type of post-transcriptional modification that includes nucleotide insertion/deletion or conversion. Different categories of RNA editing have been widely observed in distinct RNAs from divergent organisms. In flowering plants, RNA editing usually alters cytidine to uridine in plastids and mitochondria, playing important roles in various plant developmental processes, including organelle biogenesis, adaptation to environmental changes, and signal transduction. Numerous studies have demonstrated that a number of factors are involved in plant RNA editing, such as pentatricopeptide repeat (PPR) proteins, multiple organelle RNA editing factors (MORF, also known as RIP), organelle RNA recognition motif (ORRM) containing proteins, protoporphyrinogen IX oxidase 1 (PPO1) and organelle zinc finger 1 (OZ1). These factors play diverse roles in plant RNA editing due to their distinct characteristics. In this review, we discuss the functional roles of the individual editing factors and their associations in plant RNA editing.

  20. Human Genome Editing and Ethical Considerations.

    Science.gov (United States)

    Krishan, Kewal; Kanchan, Tanuj; Singh, Bahadur

    2016-04-01

    Editing human germline genes may act as boon in some genetic and other disorders. Recent editing of the genome of the human embryo with the CRISPR/Cas9 editing tool generated a debate amongst top scientists of the world for the ethical considerations regarding its effect on the future generations. It needs to be seen as to what transformation human gene editing brings to humankind in the times to come.

  1. Strategies of Qualitative Inquiry. Third Edition

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    2007-01-01

    "Strategies of Qualitative Inquiry, Third Edition," the second volume in the paperback version of "The SAGE Handbook of Qualitative Research, 3rd Edition," consists of Part III of the handbook ("Strategies of Inquiry"). "Strategies of Qualitative Inquiry, Third Edition" presents the major tactics--historically, the research methods--that…

  2. Promoting School Success. Third Edition

    Science.gov (United States)

    Lovitt, Thomas C.

    2007-01-01

    Like its two predecessors, "Preventing School Dropouts" [C1991] and "Preventing School Failure" [C2000], this third edition is a book about teaching. Although primarily written for teachers, tutors and parents may also find this book helpful. It is a collection of carefully selected teaching techniques aimed at helping young adults learn important…

  3. Money and Schools. Fifth Edition

    Science.gov (United States)

    Thompson, David C.; Crampton, Faith E.; Wood, R. Craig

    2012-01-01

    In the new edition of this essential, all-inclusive text, the authors provide more important research for future principals and others enrolled in graduate-level school finance courses. Written in a style that is highly readable, the book offers strong connections to real-world experiences. Readers get both a broad overview of funding concepts and…

  4. Nuclear Electricity. 5th Edition.

    Science.gov (United States)

    Hore-Lacy, Ian

    Educators must address the need for young people to be informed about both the scientific concepts and the reasons for controversy when dealing with controversial issues. Young people must be given the opportunity to form their own opinions when presented with evidence for conflicting arguments. Previous editions of "Nuclear Electricity" have…

  5. Veterinary Microbiology, 3rd Edition

    Science.gov (United States)

    Veterinary Microbiology, Third Edition is organized into four sections and begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral d...

  6. Gene editing. Time to reflection.

    OpenAIRE

    Santaló Pedro, Josep

    2017-01-01

    The development of new gene editing technologies and their special characteristics have led to a passionate debate on the suitability and reliability of their use both in plant and animal species and in the human species itself. A brief analysis of the arguments used in this debate as well as a summary of some of the most relevant statements in this regard is made.

  7. Proceedings of the Sixth Forum: Energy day in Croatia

    International Nuclear Information System (INIS)

    1997-01-01

    The problem of ''Regional Planning as a Part of National Energy Planning'' has been chosen as a subject of the Sixth FORUM, with the aim of giving an impetus to the necessary transfer of certain responsibilities in the planning process, as well as in the process of energy management, to local levels. Transformation procedures in Croatia which help establish the infrastructure of state and local authorities essentially lead to the recognition of tasks on each of the level so that operational activities run as efficiently as possible. It should be emphasised that on global level the energy sector is facing major changes leading to market liberalization and demonopolization. Discussion are being held regarding market range and opportunities, requirements and levels of planning, needs and scope of government and local community measures in achieving increased energy efficiency and utilization of renewable resources, and ultimately in overall energy management. The objective of this FORUM is to start discussions of all the mentioned problems without giving final solutions or removing dilemmas. The only unquestionable issue is that each country will have to find its own manner in transforming the energy sector, in defining the range and mode of planning within the sector, as well as the proportions and active involvement of the state and local community in increasing energy efficiency and environment protection. Experiences and views of our foreign colleagues are certainly going to be of great help in our efforts to review the needs of the Republic of Croatia. (author)

  8. Proceedings of the sixth annual conference on fossil energy materials

    Energy Technology Data Exchange (ETDEWEB)

    Cole, N.C.; Judkins, R.R. (comps.)

    1992-07-01

    The Sixth Annual Conference on Fossil Energy Materials was held in Oak Ridge, Tennessee, on May 12--14, 1992. The meeting was sponsored by the US Department of Energy's Office of Fossil Energy through the Advanced Research and Technology Development (AR TD) Materials Program, and ASM International. The objective of the AR TD Materials Program is to conduct research and development on materials for longer-term fossil energy applications as well as for generic needs of various fossil fuel technologies. The management of the Program has been decentralized to the DOE Field Office, Oak Ridge with Oak Ridge National Laboratory (ORNL) as the technical support contractor. The research is performed by staff members at ORNL and by a substantial number of researchers at other national laboratories, universities, and in private industry. The work is divided into the following categories: (1) ceramics, (2) development and corrosion resistance of iron aluminide, advanced austenitic and chromium-niobium alloys, and (3) technology assessment and technology transfer. This conference is held each year to review the work on all of the projects of the Program. The agenda for the meeting is given in Appendix A, and a list of attendees is presented in Appendix B. ASM International cosponsored the conference, for which we are especially grateful.

  9. Environmental situation in Austria. Sixth environmental control report

    International Nuclear Information System (INIS)

    Deweis, M.; Kaitna, M.

    2001-01-01

    This sixth environmental control report gives an overall picture of the situation of the environment in Austria for the period from 1997 to 2000. It emphasizes the areas of the Austrian environmental policy where significant improvements were achieved, such as the reduction of air pollutant emissions and the improvement of the quality of running waters. It also deals with problem areas such as transport, climate protection and renewable energy, where new solutions will have to be found within the framework of the Austrian and European environmental policies and already agreed upon strategies will have to be translated into daily practice. This environmental control report was written by experts of the Federal Environment Agency, which is an agency subordinate to the Federal Ministry for Agriculture, Forestry, Environment and Water Management, and which acquired independent status in the form of a limited company. The report gives comprehensive information on all aspects of environmental monitoring in Austria, with a huge amount of numerical, geographical and evaluated data. The report is structured by the following chapters: population and land use; air; global climate change; stratospheric ozone degradation; water; soil; forests; environmental protection; agriculture; traffic; industry; economic audit; waste; contaminated sites; energy; noise; secure handling of chemicals; plant-protective agents; gene technology; radioecology. Those chapters which are in the INIS subject scope, dealing with radioecology and ecological aspects of nuclear and non-nuclear energy are treated individually on analytical level for the INIS database. (a.n.)

  10. REQUIREMENTS FOR HAZARDOUS WASTE LANDFILL DESIGN, CONSTRUCTION AND CLOSURE

    Science.gov (United States)

    This publication contains edited versions of the material presented at ten Technology Transfer seminars conducted in 1988 on this subject. Sections are included on design of clay and flexible membrane liners, leachate collector systems, and landfill covers. Construction quality a...

  11. Book Review: Real estate, construction and economic development ...

    African Journals Online (AJOL)

    Book Title: Real estate, construction and economic development in emerging market economies. Book Authors: Edited by Raymond Talinbe Abdulai, Franklin Obeng-Odoom, Edward Ochieng, Vida Maliene. (2015). Taylor & Francis, UK. ISBN: 9780415747899 ...

  12. Optimal control problem for a sixth-order Cahn-Hilliard equation with nonlinear diffusion

    Directory of Open Access Journals (Sweden)

    Changchun Liu

    2012-08-01

    Full Text Available In this article, we study the initial-boundary-value problem for a sixth-order Cahn-Hilliard type equation $$displaylines{ u_t=D^2mu, cr mu=gamma D^4u-a(uD^2u-frac{a'(u}2|D u|^2+f(u+ku_t, }$$ which describes the separation properties of oil-water mixtures, when a substance enforcing the mixing of the phases is added. The optimal control of the sixth order Cahn-Hilliard type equation under boundary condition is given and the existence of optimal solution to the sixth order Cahn-Hilliard type equation is proved.

  13. Isolated unilateral sixth cranial nerve palsy: A rare presentation of dengue fever.

    Science.gov (United States)

    Mazliha, M; Boo, Y L; Chin, P W

    2016-01-01

    Dengue fever is a common mosquito-borne viral infection endemic in tropical and subtropical countries. Neurological manifestations in dengue infection are relatively uncommon, and include encephalitis, encephalopathy, neuromuscular disorders and neuro-ocular disorders. Cranial mononeuropathy is a rare manifestation of dengue infection. A 40-year-old man was diagnosed with isolated, unilateral sixth cranial nerve palsy complicating dengue infection. The patient was managed accordingly, and full ocular recovery was observed. This was the first reported case of isolated sixth cranial nerve palsy associated with dengue fever in Malaysia. It is important for clinicians to consider dengue as a differential diagnosis in patients presenting with fever and sixth cranial nerve palsy.

  14. Central pontine myelinolysis presenting as isolated sixth nerve palsy in third trimester of pregnancy.

    Science.gov (United States)

    Gosavi, Tushar Divakar; See, Siew Ju

    2015-01-01

    A 30-year-old primigravida presented with isolated left sixth nerve palsy at 38 weeks gestation. Her MRI showed a lesion consistent with central pontine myelinolysis (CPM). Extensive investigations did not reveal any secondary cause for the CPM. She recovered spontaneously in 2 weeks with complete resolution of her MRI changes. To our knowledge, this is the first report of CPM occurring in third trimester in the absence of identifiable secondary causes and of CPM presenting as an isolated sixth nerve palsy. We discuss the reported causes of CPM in pregnancy, possible pathophysiologic mechanisms involved and the anatomic basis of the unique clinical presentation of sixth nerve palsy in our case.

  15. Diesel Technology: Steering and Suspension. Second Edition. Teacher Edition [and] Student Edition.

    Science.gov (United States)

    Miller, Roger; Scarberry, Terry; Tesch, Carl; Kellum, Mary

    These teacher and student editions on steering and suspension are part of the diesel mechanics series of instructional materials. The series aligns with the medium/heavy duty truck task list developed by the National Automotive Technicians Education Foundation and used by the National Institute for Automotive Service Excellence in the…

  16. Diesel Technology: Safety Skills. Teacher Edition [and] Student Edition. Second Edition.

    Science.gov (United States)

    Kellum, Mary

    Teacher and student editions of this document are one in a series of competency-based instructional materials for diesel technology programs. The series aligns with the medium/heavy diesel duty truck task list used by the National Institute for Automotive Service Excellence in the certification of medium/heavy duty truck technicians. Introductory…

  17. Childhood Career Development Scale: Scale Construction and Psychometric Properties

    Science.gov (United States)

    Schultheiss, Donna E. Palladino; Stead, Graham B.

    2004-01-01

    The purpose of this investigation was to construct a theoretically driven and psychometrically sound childhood career development scale to measure career progress in fourth-through sixth-grade children. Super's nine dimensions (i.e., curiosity, exploration, information, key figures, interests, locus of control, time perspective, self-concept, and…

  18. Statistical Physics Approaches to RNA Editing

    Science.gov (United States)

    Bundschuh, Ralf

    2012-02-01

    The central dogma of molecular Biology states that DNA is transcribed base by base into RNA which is in turn translated into proteins. However, some organisms edit their RNA before translation by inserting, deleting, or substituting individual or short stretches of bases. In many instances the mechanisms by which an organism recognizes the positions at which to edit or by which it performs the actual editing are unknown. One model system that stands out by its very high rate of on average one out of 25 bases being edited are the Myxomycetes, a class of slime molds. In this talk we will show how the computational methods and concepts from statistical Physics can be used to analyze DNA and protein sequence data to predict editing sites in these slime molds and to guide experiments that identified previously unknown types of editing as well as the complete set of editing events in the slime mold Physarum polycephalum.

  19. Progress and prospects in plant genome editing.

    Science.gov (United States)

    Yin, Kangquan; Gao, Caixia; Qiu, Jin-Long

    2017-07-31

    The emergence of sequence-specific nucleases that enable genome editing is revolutionizing basic and applied biology. Since the introduction of CRISPR-Cas9, genome editing has become widely used in transformable plants for characterizing gene function and improving traits, mainly by inducing mutations through non-homologous end joining of double-stranded breaks generated by CRISPR-Cas9. However, it would be highly desirable to perform precision gene editing in plants, especially in transformation-recalcitrant species. Recently developed Cas9 variants, novel RNA-guided nucleases and base-editing systems, and DNA-free CRISPR-Cas9 delivery methods now provide great opportunities for plant genome engineering. In this Review Article, we describe the current status of plant genome editing, focusing on newly developed genome editing tools and methods and their potential applications in plants. We also discuss the specific challenges facing plant genome editing, and future prospects.

  20. Complexity in Coalition Operations: The Campaign of the Sixth Coalition Against Napoleon

    National Research Council Canada - National Science Library

    Turner, Kenneth

    2003-01-01

    The Campaign of the Sixth Coalition, from the Summer of 1813 until the abdication of Napoleon in April 1814, offers some important and valid insights into the successful execution of coalition warfare...

  1. Calvarial-orbital Metastasis of Prostate Carcinoma which was Diagnosed with Sixth Cranial Nerve Palsy.

    Science.gov (United States)

    Özbek, Zühtü; Özkara, Emre; Arik, Deniz; Ant, Metin Atasoy

    2017-01-01

    Sixth nerve palsy is frequently due to infectious orbital lesions, trauma, elevated intracranial pressure, brainstem lesions, and vasculopathies. Here, we describe a rare cause of sixth cranial nerve (CN) palsy secondary to calvarial and orbital metastasis of prostate carcinoma. The diagnosis of the prostate carcinoma with sixth CN palsy is a very rare condition. A 66-year-old male patient presented with complaints of blurred vision, double vision, and inability to move outward in the right eye for 3 weeks. Magnetic resonance imaging revealed a right orbitocalvarial mass and the mass surgically removed completely. Pathologic findings were compatible with prostate adenocarcinoma metastasis. After surgical removal, significant improvement in sixth CN palsy was observed.

  2. Sixth International Conference on Squeezed States and Uncertainty Relations

    Science.gov (United States)

    Han, D. (Editor); Kim, Y. S. (Editor); Solimento, S. (Editor)

    2000-01-01

    These proceedings contain contributions from about 200 participants to the 6th International Conference on Squeezed States and Uncertainty Relations (ICSSUR'99) held in Naples May 24-29, 1999, and organized jointly by the University of Naples "Federico II," the University of Maryland at College Park, and the Lebedev Institute, Moscow. This was the sixth of a series of very successful meetings started in 1990 at the College Park Campus of the University of Maryland. The other meetings in the series were held in Moscow (1992), Baltimore (1993), Taiyuan P.R.C. (1995) and Balatonfuered, Hungary (1997). The present one was held at the campus Monte Sant'Angelo of the University "Federico II" of Naples. The meeting sought to provide a forum for updating and reviewing a wide range of quantum optics disciplines, including device developments and applications, and related areas of quantum measurements and quantum noise. Over the years, the ICSSUR Conference evolved from a meeting on quantum measurement sector of quantum optics, to a wide range of quantum optics themes, including multifacet aspects of generation, measurement, and applications of nonclassical light (squeezed and Schrodinger cat radiation fields, etc.), and encompassing several related areas, ranging from quantum measurement to quantum noise. ICSSUR'99 brought together about 250 people active in the field of quantum optics, with special emphasis on nonclassical light sources and related areas. The Conference was organized in 8 Sections: Squeezed states and uncertainty relations; Harmonic oscillators and squeeze transformations; Methods of quantum interference and correlations; Quantum measurements; Generation and characterisation of non-classical light; Quantum noise; Quantum communication and information; and Quantum-like systems.

  3. TALE: a tale of genome editing.

    Science.gov (United States)

    Zhang, Mingjie; Wang, Feng; Li, Shifei; Wang, Yan; Bai, Yun; Xu, Xueqing

    2014-01-01

    Transcription activator-like effectors (TALEs), first identified in Xanthomonas bacteria, are naturally occurring or artificially designed proteins that modulate gene transcription. These proteins recognize and bind DNA sequences based on a variable numbers of tandem repeats. Each repeat is comprised of a set of ∼ 34 conserved amino acids; within this conserved domain, there are usually two amino acids that distinguish one TALE from another. Interestingly, TALEs have revealed a simple cipher for the one-to-one recognition of proteins for DNA bases. Synthetic TALEs have been used to successfully target genes in a variety of species, including humans. Depending on the type of functional domain that is fused to the TALE of interest, these proteins can have diverse biological effects. For example, after binding DNA, TALEs fused to transcriptional activation domains can function as robust transcription factors (TALE-TFs), while fused to restriction endonucleases (TALENs) can cut DNA. Targeted genome editing, in theory, is capable of modifying any endogenous gene sequence of interest; this can be performed in cells or organisms, and may be applied to clinical gene-based therapies in the future. With current technologies, highly accurate, specific, and reliable gene editing cannot be achieved. Thus, recognition and binding mechanisms governing TALE biology are currently hot research areas. In this review, we summarize the major advances in TALE technology over the past several years with a focus on the interaction between TALEs and DNA, TALE design and construction, potential applications for this technology, and unique characteristics that make TALEs superior to zinc finger endonucleases. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Country Nuclear Power Profiles - 2007 Edition

    International Nuclear Information System (INIS)

    2008-01-01

    The preparation of Country Nuclear Power Profiles (CNPP) was initiated within the framework of the IAEA's programme on assessment and feedback of nuclear power plant performance. It responded to a need for a database and a technical publication containing a description of the energy and economic situation, the energy and the electricity sector, and the primary organizations involved in nuclear power in IAEA Member States. It covers background information on the status and development of nuclear power programmes in countries having nuclear plants in operation and/or plants under construction. This is the 2007 edition issued on CD-ROM and Web pages. It updates the country information, in general, to the end of 2006 for 39 countries. The CNPP is updated based on information voluntarily provided by participating IAEA Member States. Participants include the 30 countries that have operating nuclear power plants, as well as nine countries having past or planned nuclear power programmes (Bangladesh, Egypt, Indonesia, the Islamic Republic of Iran, Italy, Kazakhstan, Poland, Turkey, and Vietnam). For the 2007 edition, 21 countries provided information to the IAEA to update their profiles. For the 18 other countries, the IAEA updated the profile statistical tables on nuclear power, energy development, and economic indicators based on information from IAEA and World Bank databases. These 18 countries are Argentina, Belgium, Bulgaria, Canada, China, Egypt, Finland, Indonesia, Japan, Mexico, Netherlands, Poland, Romania, Slovenia, South Africa, Spain, Switzerland, and Ukraine. Overall, the CNPP reviews the organizational and industrial aspects of nuclear power programmes in participating countries, and provides information about the relevant legislative, regulatory and international frameworks in each country. It compiles the current issues in the new environment within which the electricity and nuclear sector operates, i.e. energy policy, and privatization and deregulation in

  5. Effects of LEGO Mindstorms on convergent and divergent problem-solving and spatial abilities in fifth and sixth grade students

    Science.gov (United States)

    Gibbon, Lance W.

    In this quasi-experimental study, 142 fifth and sixth grade students at a suburban elementary school in Northwest Washington State participated in a week-long, 10-hour project using the LEGO Mindstorms Robotics Invention System (RIS). Partners constructed and programmed one robot from visually-based LEGO instructions and a second of their own creation and then shared them at a culminating event. The study is built upon on the constructionist philosophy of Seymour Papert (1980; 1990; 1993; 1999) and an investigation of problem-solving and LEGO robotics by Debra and David Palumbo (1993). A modified switching-replications design provided 3 complete replications within the study and allowed all participants to receive the treatment. Pre and posttests were given. Convergent problem-solving and spatial ability were measured by the Ravens Progressive Matrices (RPM) and divergent problem-solving ability was measured by the Fluency and Flexibility Measure (FFM). The FFM was constructed by the researcher. The development process, piloting, and implementation of this instrument are reported. Overall, Mindstorms did not have a significant effect on convergent problem-solving and spatial reasoning as measured by the RPM. However, infrequent LEGO's users made greater gains on the RPM during the treatment than frequent users, but frequent LEGO users made notable gains during the comparison condition. The multiplicative interaction effect of Testing, Group, and LEGO Use across replications on the RPM is significant, pLEGO users scored higher than the comparison group on Fluency for all three replications (p=.384, p=.035, p=.090). There was no clear pattern of gender differences on the RPM or FFM. This study provides tentative signs that using LEGO Mindstorms has a positive effect on divergent problem-solving. Frequent LEGO users also appear advantaged on both convergent and divergent measures. There are indications that fifth graders benefited more from Mindstorms than sixth

  6. New exact solutions of sixth-order thin-film equation

    Directory of Open Access Journals (Sweden)

    Wafaa M. Taha

    2014-01-01

    Full Text Available TheG′G-expansion method is used for the first time to find traveling-wave solutions for the sixth-order thin-film equation, where related balance numbers are not the usual positive integers. New types of exact traveling-wave solutions, such as – solitary wave solutions, are obtained the sixth-order thin-film equation, when parameters are taken at special values.

  7. Maffucci syndrome and intracranial chondrosarcomas: a case report featuring spontaneous resolution of sixth nerve palsy.

    Science.gov (United States)

    Munro, Monique; Costello, Fiona; Burrowes, David; Yau, Ryan

    2015-03-01

    Maffucci syndrome is a rare disease process characterized by enchondromatosis with cutaneous hemangiomatosis. We report a 20-year-old woman with Maffucci syndrome with a 5-day history of diplopia. She was found to have a left sixth nerve palsy due to a parasellar chondrosarcoma. Three weeks later, the patient's diplopia spontaneously resolved. This unusual clinical course prompted us to review frequency of sixth nerve palsy with skull base neoplasms and the phenomenon of spontaneous resolution of diplopia.

  8. Relapsing-Remitting Sixth Nerve Palsy in Association with Ollier's Disease.

    Science.gov (United States)

    Raoof, Naz; Batty, Ruth; Carroll, Thomas A; Pepper, Irene M; Sandison, Ann; Eckersley, Rupert; Hickman, Simon J

    2015-04-01

    Relapsing-remitting sixth nerve palsy is usually due to ophthalmoplegic migraine (recurrent cranial nerve palsy) in younger patients and microvascular disease in older patients. There have been isolated reports, however, of it occurring in the presence of a skull base tumour. We report a 20-year-old woman with Ollier's disease who presented with a relapsing-remitting sixth nerve palsy. Neuro-imaging revealed a skull base enchondroma.

  9. Relapsing-Remitting Sixth Nerve Palsy in Association with Ollier’s Disease

    OpenAIRE

    Raoof, Naz; Batty, Ruth; Carroll, Thomas A.; Pepper, Irene M.; Sandison, Ann; Eckersley, Rupert; Hickman, Simon J.

    2015-01-01

    Relapsing-remitting sixth nerve palsy is usually due to ophthalmoplegic migraine (recurrent cranial nerve palsy) in younger patients and microvascular disease in older patients. There have been isolated reports, however, of it occurring in the presence of a skull base tumour. We report a 20-year-old woman with Ollier’s disease who presented with a relapsing-remitting sixth nerve palsy. Neuro-imaging revealed a skull base enchondroma.

  10. Augmented superior rectus transposition procedure in Duane retraction syndrome compared with sixth nerve palsy.

    Science.gov (United States)

    Akbari, Mohammadreza; Shomali, Setareh; Mirmohammadsadeghi, Arash; Fard, Masoud Aghsaei

    2018-01-03

    Superior rectus transposition (SRT) with medial rectus recession has been used for the treatment of sixth nerve palsy and esotropic Duane retraction syndrome (DRS). The purpose of this study was to compare the results of augmented SRT (with scleral fixation) without medial rectus recession in DRS and sixth nerve palsy. Patients with unilateral esotropic DRS (DRS group) and sixth nerve palsy were included in this prospective, comparative study and underwent SRT. Preoperative forced duction testing was negative or slightly positive in both groups. Prospective measurements were compared between the two groups. There were 11 patients in the DRS group and 11 patients in the sixth nerve palsy group. The mean preoperative esotropia decreased from 20.9 ± 6.0 prism diopter (PD) at far to 13.2 ± 5.8 PD in the DRS group (P = 0.003). The same measurement improved from 28.0 ± 8.5 PD to 8.4 ± 7.3 PD in the sixth nerve palsy group (P = 0.003). In the sixth nerve palsy group, the improvement in primary gaze esotropia and abnormal head posture was more than the DRS group (Both P sixth nerve palsy group. Although objective intorsion was significantly induced after SRT, subjective torsion was not significant after surgery in both groups. SRT appears to be more effective in improving primary gaze deviation and head posture in sixth nerve palsy compared with DRS. Subjective torsional and vertical diplopia were rare in both groups.

  11. Application Progress of CRISPR/Cas9 System for Gene Editing in Tumor Research

    Directory of Open Access Journals (Sweden)

    Chao LIU

    2015-09-01

    Full Text Available TCRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR-associated nuclease 9 gene editing system is a new type of gene editing technology developed based on the immune mechanism of archaea resisting the invasion of exogenous nucleic acid. Compared with traditional gene editing system, CRISPR/Cas9 system is more efficient, easier operating, and less cytotoxic. Currently, CRISPR/Cas9 gene editing technology has been applied to many aspects of cancer research, including research on cancer genes, constructing animal tumor models, screening tumor resistance-associated and phenotypic-related genes and cancer gene therapy. In this review, the application of the CRISPR/Cas9 system in tumor research were introduced.

  12. CRISPR-Cas9 Toolkit for Actinomycete Genome Editing

    DEFF Research Database (Denmark)

    Tong, Yaojun; Robertsen, Helene Lunde; Blin, Kai

    2018-01-01

    engineering approaches for boosting known and discovering novel natural products. In order to facilitate the genome editing for actinomycetes, we developed a CRISPR-Cas9 toolkit with high efficiency for actinomyces genome editing. This basic toolkit includes a software for spacer (sgRNA) identification......, a system for in-frame gene/gene cluster knockout, a system for gene loss-of-function study, a system for generating a random size deletion library, and a system for gene knockdown. For the latter, a uracil-specific excision reagent (USER) cloning technology was adapted to simplify the CRISPR vector...... construction process. The application of this toolkit was successfully demonstrated by perturbation of genomes of Streptomyces coelicolor A3(2) and Streptomyces collinus Tü 365. The CRISPR-Cas9 toolkit and related protocol described here can be widely used for metabolic engineering of actinomycetes....

  13. Editing as a psychological practice.

    Science.gov (United States)

    Beebe, John

    2006-06-01

    The experience of the Jungian analyst in the role of editor of manuscripts by creative colleagues is examined. Historical precedents include Michael Fordham's editorial correspondence with Jung around the latter's synchronicity essay; Jung's handling of manuscripts submitted by Sabina Spielrein to the Jahrbuch für psychoanalytische und psychopathologische Forschungen and various authors to the Zentralblatt für Psychotherapie und ihre Grenzgebiete, and the author's close editing of a paper submitted by Andrew Samuels to the Journal of Analytical Psychology. In addition to mustering an adequate amount of generosity, erudition, and availability, the analytic editor must know how to clarify a psychological argument and to gauge the psychological impact of the written text. Notwithstanding transference/countertransference phenomena that can emerge around issues of competition, envy, and territoriality when author and editor are also fellow-authors working in the same field, the editor needs to be comfortable about serving as the author's selfobject and midwife. From an analytic perspective, although communicating decisions about the best way to put ideas into words can sometimes attract transference to the editor, the more profound transference that analysts experience in the editing situation is toward the text being edited, which helps to motivate donated time spent caring for journal manuscripts.

  14. Construction contracts law and management

    CERN Document Server

    Hughes, Will; Murdoch, John

    2015-01-01

    The fifth edition of this bestselling textbook has been thoroughly revised to provide the most up-to-date and comprehensive coverage of the legislation, administration and management of construction contracts. It now includes comparisons of working with JCT, NEC3, and FIDIC contracts throughout. Introducing this topic at the core of construction law and management, this book provides students with a one-stop reference on construction contracts. Significant new material covers: procurement tendering developments in dispute settlement commentary on all key legislation, case law and contract amendments In line with new thinking in construction management research, this authoritative guide is essential reading for every construction undergraduate and an extremely useful source of reference for practitioners.

  15. PREFACE: The Sixth International Conference on Gravitation & Cosmology

    Science.gov (United States)

    Date, Ghanashyam; Souradeep, Tarun

    2008-07-01

    The sixth International Conference on Gravitation & Cosmology (ICGC-2007) was organized at IUCAA, Pune, 17-21 December 2007. This series of international meetings, held every four years under the auspices of the Indian Association for General Relativity and Gravitation (IAGRG), has now spanned two decades. Previous ICGC meetings were held at Cochin University of Science and Technology (2004), Indian Institute of Technology, Kharagpur (2000), IUCAA, Pune (1995), Physical Research Laboratory, Ahmedabad (1991) & Goa (1987). These meetings have broad international participation and feature leading experts in the field of Cosmology, gravitational waves and quantum gravity. The frontier of research in Gravitation and Cosmology has seen remarkable progress in the past decades. On the theoretical front, black holes and cosmological singularities continue to challenge and attract quantum gravity researchers. The quest for the detection of Gravitational waves and the promise of gravitational wave astronomy continues to grow and breakthroughs of the past couple of years indicate that numerical relativity is catching up too. The past few years have also seen very ambitious experimental efforts to verify general relativity as the theory of gravitation. Cosmology has been veritably transformed into a precision science with the tremendous improvement in the quantity and quality of cosmological observations. The exquisite measurements not only allow refinement of the cosmological model parameters but have begun to allow observational tests of underlying fundamental assumptions and hunt for subtle deviations that could be the key to understanding the early universe. The sixth meeting brought together active scientists from all over the globe to present the state of the art at the frontiers of research. It also offered younger Indian researchers an opportunity for interaction with experts from within India and abroad. The meeting was attended by over 160 participants. The scientific

  16. RNA editing in plants and its evolution.

    Science.gov (United States)

    Takenaka, Mizuki; Zehrmann, Anja; Verbitskiy, Daniil; Härtel, Barbara; Brennicke, Axel

    2013-01-01

    RNA editing alters the identity of nucleotides in RNA molecules such that the information for a protein in the mRNA differs from the prediction of the genomic DNA. In chloroplasts and mitochondria of flowering plants, RNA editing changes C nucleotides to U nucleotides; in ferns and mosses, it also changes U to C. The approximately 500 editing sites in mitochondria and 40 editing sites in plastids of flowering plants are individually addressed by specific proteins, genes for which are amplified in plant species with organellar RNA editing. These proteins contain repeat elements that bind to cognate RNA sequence motifs just 5' to the edited nucleotide. In flowering plants, the site-specific proteins interact selectively with individual members of a different, smaller family of proteins. These latter proteins may be connectors between the site-specific proteins and the as yet unknown deaminating enzymatic activity.

  17. Connectivity editing for quad-dominant meshes

    KAUST Repository

    Peng, Chihan

    2013-08-01

    We propose a connectivity editing framework for quad-dominant meshes. In our framework, the user can edit the mesh connectivity to control the location, type, and number of irregular vertices (with more or fewer than four neighbors) and irregular faces (non-quads). We provide a theoretical analysis of the problem, discuss what edits are possible and impossible, and describe how to implement an editing framework that realizes all possible editing operations. In the results, we show example edits and illustrate the advantages and disadvantages of different strategies for quad-dominant mesh design. © 2013 The Author(s) Computer Graphics Forum © 2013 The Eurographics Association and John Wiley & Sons Ltd.

  18. Modelling in Primary School: Constructing Conceptual Models and Making Sense of Fractions

    Science.gov (United States)

    Shahbari, Juhaina Awawdeh; Peled, Irit

    2017-01-01

    This article describes sixth-grade students' engagement in two model-eliciting activities offering students the opportunity to construct mathematical models. The findings show that students utilized their knowledge of fractions including conceptual and procedural knowledge in constructing mathematical models for the given situations. Some students…

  19. The diagnostic yield of neuroimaging in sixth nerve palsy - Sankara Nethralaya Abducens Palsy Study (SNAPS: Report 1

    Directory of Open Access Journals (Sweden)

    Akshay Gopinathan Nair

    2014-01-01

    Full Text Available Aims: The aim was to assess the etiology of sixth nerve palsy and on the basis of our data, to formulate a diagnostic algorithm for the management in sixth nerve palsy. Design: Retrospective chart review. Results: Of the 104 neurologically isolated cases, 9 cases were attributable to trauma, and 95 (86.36% cases were classified as nontraumatic, neurologically isolated cases. Of the 95 nontraumatic, isolated cases of sixth nerve palsy, 52 cases were associated with vasculopathic risk factors, namely diabetes and hypertension and were classified as vasculopathic sixth nerve palsy (54.7%, and those with a history of sixth nerve palsy from birth (6 cases were classified as congenital sixth nerve palsy (6.3%. Of the rest, neuroimaging alone yielded a cause in 18 of the 37 cases (48.64%. Of the other 19 cases where neuroimaging did not yield a cause, 6 cases were attributed to preceding history of infection (3 upper respiratory tract infection and 3 viral illnesses, 2 cases of sixth nerve palsy were found to be a false localizing sign in idiopathic intracranial hypertension and in 11 cases, the cause was undetermined. In these idiopathic cases of isolated sixth nerve palsy, neuroimaging yielded no positive findings. Conclusions: In the absence of risk factors, a suggestive history, or positive laboratory and clinical findings, neuroimaging can serve as a useful diagnostic tool in identifying the exact cause of sixth nerve palsy. Furthermore, we recommend an algorithm to assess the need for neuroimaging in sixth nerve palsy.

  20. The diagnostic yield of neuroimaging in sixth nerve palsy - Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1

    Science.gov (United States)

    Nair, Akshay Gopinathan; Ambika, Selvakumar; Noronha, Veena Olma; Gandhi, Rashmin Anilkumar

    2014-01-01

    Aims: The aim was to assess the etiology of sixth nerve palsy and on the basis of our data, to formulate a diagnostic algorithm for the management in sixth nerve palsy. Design: Retrospective chart review. Results: Of the 104 neurologically isolated cases, 9 cases were attributable to trauma, and 95 (86.36%) cases were classified as nontraumatic, neurologically isolated cases. Of the 95 nontraumatic, isolated cases of sixth nerve palsy, 52 cases were associated with vasculopathic risk factors, namely diabetes and hypertension and were classified as vasculopathic sixth nerve palsy (54.7%), and those with a history of sixth nerve palsy from birth (6 cases) were classified as congenital sixth nerve palsy (6.3%). Of the rest, neuroimaging alone yielded a cause in 18 of the 37 cases (48.64%). Of the other 19 cases where neuroimaging did not yield a cause, 6 cases were attributed to preceding history of infection (3 upper respiratory tract infection and 3 viral illnesses), 2 cases of sixth nerve palsy were found to be a false localizing sign in idiopathic intracranial hypertension and in 11 cases, the cause was undetermined. In these idiopathic cases of isolated sixth nerve palsy, neuroimaging yielded no positive findings. Conclusions: In the absence of risk factors, a suggestive history, or positive laboratory and clinical findings, neuroimaging can serve as a useful diagnostic tool in identifying the exact cause of sixth nerve palsy. Furthermore, we recommend an algorithm to assess the need for neuroimaging in sixth nerve palsy. PMID:25449936

  1. The diagnostic yield of neuroimaging in sixth nerve palsy--Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1.

    Science.gov (United States)

    Nair, Akshay Gopinathan; Ambika, Selvakumar; Noronha, Veena Olma; Gandhi, Rashmin Anilkumar

    2014-10-01

    The aim was to assess the etiology of sixth nerve palsy and on the basis of our data, to formulate a diagnostic algorithm for the management in sixth nerve palsy. Retrospective chart review. Of the 104 neurologically isolated cases, 9 cases were attributable to trauma, and 95 (86.36%) cases were classified as nontraumatic, neurologically isolated cases. Of the 95 nontraumatic, isolated cases of sixth nerve palsy, 52 cases were associated with vasculopathic risk factors, namely diabetes and hypertension and were classified as vasculopathic sixth nerve palsy (54.7%), and those with a history of sixth nerve palsy from birth (6 cases) were classified as congenital sixth nerve palsy (6.3%). Of the rest, neuroimaging alone yielded a cause in 18 of the 37 cases (48.64%). Of the other 19 cases where neuroimaging did not yield a cause, 6 cases were attributed to preceding history of infection (3 upper respiratory tract infection and 3 viral illnesses), 2 cases of sixth nerve palsy were found to be a false localizing sign in idiopathic intracranial hypertension and in 11 cases, the cause was undetermined. In these idiopathic cases of isolated sixth nerve palsy, neuroimaging yielded no positive findings. In the absence of risk factors, a suggestive history, or positive laboratory and clinical findings, neuroimaging can serve as a useful diagnostic tool in identifying the exact cause of sixth nerve palsy. Furthermore, we recommend an algorithm to assess the need for neuroimaging in sixth nerve palsy.

  2. Summary Record of the Sixth Meeting of Records, Knowledge and Memory (RK and M) Across Generations

    International Nuclear Information System (INIS)

    2014-01-01

    Preservation of Records, Knowledge and Memory (RK and M) across Generations is an initiative under the RWMC in the area of knowledge consolidation and transfer. Disposal in engineered facilities built in stable, deep geological formations is the reference means for permanently isolating long-lived radioactive waste from the biosphere. However, there is no intention to forgo, at any time, knowledge and awareness either of the repository or of the waste that it contains. The cultural dimension of preserving RK and M is an important subject. Overall, long-term preservation of RK and M is a multidisciplinary work area in which much learning is expected over the coming years. This is the task of the RWMC's RK and M initiative. A major outcome will be a menu-driven document that - the RK and M Wiki - that will allow people to identify the elements of a strategic action plan for RK and M preservation. This document is a summary record of the Sixth Meeting of Records, Knowledge and Memory (RK and M) Across Generations. The summary is made of 8 items: 1 - Introduction (C. Pescatore): Welcome and opening remarks, Review and adoption of the agenda, Aim of this meeting, Status report, Report from RepMet meeting; 2 - Finalising Phase-II: Updating the Set of Essential Records (SER) proposal (C. Mays), Updates to the Bibliography (A. Claudel), Additions to the Glossary (S. Hotzel); 3 - Internal Wiki Workshop: The RK and M Wiki (P. Maupai), Updating your own country, organisation and regulatory requirement page, General discussion on the wiki; 4 - Strategic Articles: Presentation on Tsunami Stones paper (R. Botez); 5 - Constructing Memory: Verdun 2014 Conference; 6 - Phase-II: Discussion and final approval of Phase-II Proposal (C. Pescatore), Proposal for RWMC collective statement - Flyer on guiding principles, Calendar; 7 - Additional aspects; 8 - Review of Decisions and Closure of the Meeting, Summary of Decision and actions

  3. Operational Transformation In Co-Operative Editing

    Directory of Open Access Journals (Sweden)

    Mandeep Kaur

    2015-08-01

    Full Text Available Cooperative Editing Systems in real-time allows a virtual team to view and edit a shared document at the same time. The document shared must be synchronized in order to ensure consistency for all the participants. This paper describes the Operational Transformation the evolution of its techniques its various applications major issues and achievements. In addition this paper will present working of a platform where two users can edit a code programming file at the same time.

  4. Constructed Wetlands

    Science.gov (United States)

    these systems can improve water quality, engineers and scientists construct systems that replicate the functions of natural wetlands. Constructed wetlands are treatment systems that use natural processes

  5. Incidence, associations, and evaluation of sixth nerve palsy using a population-based method.

    Science.gov (United States)

    Patel, Sanjay V; Mutyala, Srinivas; Leske, David A; Hodge, David O; Holmes, Jonathan M

    2004-02-01

    To determine the incidence of sixth nerve palsy in a population-based study, with particular emphasis on associated coexisting medical conditions and to use these data to develop a management algorithm. Retrospective, population-based case series. All residents of Olmsted County, Minnesota, USA, diagnosed with sixth nerve palsy between January 1, 1978 and December 31, 1992. All cases were identified by using the Rochester Epidemiology Project medical records linkage system, which captures all patient-physician encounters in Olmsted County. The entire medical record of each patient was reviewed to confirm the diagnosis, document county residency, and to determine associated medical conditions. We used stringent predetermined criteria to define diabetes mellitus and hypertension as associations. Incidence rates were adjusted to the age and gender distribution of the 1990 white population in the United States. Etiology or systemic associations of the palsy. We identified 137 new cases of sixth nerve palsy over the 15-year period. The age- and gender-adjusted annual incidence of sixth nerve palsy was 11.3/100 000 (95% confidence interval, 9.3-13.2/100 000). Causes and associations were: undetermined (26%), hypertension alone (19%), coexistent hypertension and diabetes (12%), trauma (12%), multiple sclerosis (7%), neoplasm (5%), diabetes alone (4%), cerebrovascular accident (4%), postneurosurgery (3%), aneurysm (2%), and other (8%). When sixth nerve palsy was the presenting sign in cases of neoplasm (n = 1) and aneurysm (n = 3), history and examination revealed the presence of other neurologic symptoms or signs. We provide population-based data on the incidence of sixth nerve palsy with a notably lower incidence of neoplasm and higher incidence of diabetes and hypertension than previous institution-based series. We suggest that patients with nontraumatic neurologically isolated sixth nerve palsy may undergo a focused medical evaluation followed by close observation

  6. Learning to write in science: A study of English language learners' writing experience in sixth-grade science classrooms

    Science.gov (United States)

    Qi, Yang

    Writing is a predictor of academic achievement and is essential for student success in content area learning. Despite its importance, many students, including English language learners (ELLs), struggle with writing. There is thus a need to study students' writing experience in content area classrooms. Informed by systemic functional linguistics, this study examined 11 ELL students' writing experience in two sixth grade science classrooms in a southeastern state of the United States, including what they wrote, how they wrote, and why they wrote in the way they did. The written products produced by these students over one semester were collected. Also collected were teacher interviews, field notes from classroom observations, and classroom artifacts. Student writing samples were first categorized into extended and nonextended writing categories, and each extended essay was then analyzed with respect to its schematic structure and grammatical features. Teacher interviews and classroom observation notes were analyzed thematically to identify teacher expectations, beliefs, and practices regarding writing instruction for ELLs. It was found that the sixth-grade ELLs engaged in mostly non-extended writing in the science classroom, with extended writing (defined as writing a paragraph or longer) constituting roughly 11% of all writing assignments. Linguistic analysis of extended writing shows that the students (a) conveyed information through nouns, verbs, adjectives, adverbial groups and prepositional phrases; (b) constructed interpersonal context through choices of mood, modality, and verb tense; and (c) structured text through thematic choices and conjunctions. The appropriateness of these lexicogrammatical choices for particular writing tasks was related to the students' English language proficiency levels. The linguistic analysis also uncovered several grammatical problems in the students' writing, including a limited range of word choices, inappropriate use of mood

  7. Fuel Cell Handbook, Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

    1998-11-01

    Robust progress has been made in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in January 1994. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultra high efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 6 describe the four major fuel cell types and their performance based on cell operating conditions. The section on polymer electrolyte membrane fuel cells has been added to reflect their emergence as a significant fuel cell technology. Phosphoric acid, molten carbonate, and solid oxide fuel cell technology description sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

  8. adjudication and arbitrability of government construction disputes

    African Journals Online (AJOL)

    eliasn

    the principle of confidentiality in international commercial arbitration cou- pled with their sensitivity to the reputation .... where the contract is in the nature of an administrative contract. [Emphasis supplied]. The scope of ..... Design and Supervision of Construction Works (The January1990 edition). It can nevertheless be easily ...

  9. GPU Computing Gems Emerald Edition

    CERN Document Server

    Hwu, Wen-mei W

    2011-01-01

    ".the perfect companion to Programming Massively Parallel Processors by Hwu & Kirk." -Nicolas Pinto, Research Scientist at Harvard & MIT, NVIDIA Fellow 2009-2010 Graphics processing units (GPUs) can do much more than render graphics. Scientists and researchers increasingly look to GPUs to improve the efficiency and performance of computationally-intensive experiments across a range of disciplines. GPU Computing Gems: Emerald Edition brings their techniques to you, showcasing GPU-based solutions including: Black hole simulations with CUDA GPU-accelerated computation and interactive display of

  10. A longitudinal study of school connectedness and academic outcomes across sixth grade.

    Science.gov (United States)

    Niehaus, Kate; Rudasill, Kathleen Moritz; Rakes, Christopher R

    2012-08-01

    The current longitudinal study examines the extent to which school connectedness (i.e., students' perceptions of school support and the number of adults with whom they have a positive relationship) is associated with academic outcomes across sixth grade for students from high poverty neighborhoods. Data were collected from 330 sixth-grade students attending two middle schools in a large public school district. Specifically, students completed a survey to assess their perceived connection to the school environment, and academic information regarding students' grades, attendance, and discipline referrals was obtained from school records. Results from latent growth curve modeling showed that, on average, students' perceptions of school support declined significantly across the sixth-grade year. However, students who reported less decline, or growth, in school support across sixth grade had higher academic achievement at the end of the year than students who reported more decline in school support. Sixth-grade boys were at a greater risk for negative outcomes (i.e., lower school support, lower GPAs, and more discipline referrals) across the school year than girls. Results point to the importance of perceived connectedness to school in helping economically disadvantaged students experience a safe and successful transition to middle school. Copyright © 2012 Society for the Study of School Psychology. All rights reserved.

  11. Construction management

    CERN Document Server

    Pellicer, Eugenio; Teixeira, José C; Moura, Helder P; Catalá, Joaquín

    2014-01-01

    The management of construction projects is a wide ranging and challenging discipline in an increasingly international industry, facing continual challenges and demands for improvements in safety, in quality and cost control, and in the avoidance of contractual disputes. Construction Management grew out of a Leonardo da Vinci project to develop a series of Common Learning Outcomes for European Managers in Construction. Financed by the European Union, the project aimed to develop a library of basic materials for developing construction management skills for use in a pan-European context. Focused exclusively on the management of the construction phase of a building project from the contractor's point of view, Construction Management covers the complete range of topics of which mastery is required by the construction management professional for the effective delivery of new construction projects. With the continued internationalisation of the construction industry, Construction Management will be required rea...

  12. The diagnostic yield of neuroimaging in sixth nerve palsy - Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1

    OpenAIRE

    Nair, Akshay Gopinathan; Ambika, Selvakumar; Noronha, Veena Olma; Gandhi, Rashmin Anilkumar

    2014-01-01

    Aims: The aim was to assess the etiology of sixth nerve palsy and on the basis of our data, to formulate a diagnostic algorithm for the management in sixth nerve palsy. Design: Retrospective chart review. Results: Of the 104 neurologically isolated cases, 9 cases were attributable to trauma, and 95 (86.36%) cases were classified as nontraumatic, neurologically isolated cases. Of the 95 nontraumatic, isolated cases of sixth nerve palsy, 52 cases were associated with vasculopathic risk factors,...

  13. A comprehensive overview of computational resources to aid in precision genome editing with engineered nucleases.

    Science.gov (United States)

    Periwal, Vinita

    2017-07-01

    Genome editing with engineered nucleases (zinc finger nucleases, TAL effector nucleases s and Clustered regularly inter-spaced short palindromic repeats/CRISPR-associated) has recently been shown to have great promise in a variety of therapeutic and biotechnological applications. However, their exploitation in genetic analysis and clinical settings largely depends on their specificity for the intended genomic target. Large and complex genomes often contain highly homologous/repetitive sequences, which limits the specificity of genome editing tools and could result in off-target activity. Over the past few years, various computational approaches have been developed to assist the design process and predict/reduce the off-target activity of these nucleases. These tools could be efficiently used to guide the design of constructs for engineered nucleases and evaluate results after genome editing. This review provides a comprehensive overview of various databases, tools, web servers and resources for genome editing and compares their features and functionalities. Additionally, it also describes tools that have been developed to analyse post-genome editing results. The article also discusses important design parameters that could be considered while designing these nucleases. This review is intended to be a quick reference guide for experimentalists as well as computational biologists working in the field of genome editing with engineered nucleases. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Algebra Word Problem Solving Approaches in a Chemistry Context: Equation Worked Examples versus Text Editing

    Science.gov (United States)

    Ngu, Bing Hiong; Yeung, Alexander Seeshing

    2013-01-01

    Text editing directs students' attention to the problem structure as they classify whether the texts of word problems contain sufficient, missing or irrelevant information for working out a solution. Equation worked examples emphasize the formation of a coherent problem structure to generate a solution. Its focus is on the construction of three…

  15. Psychometric Properties of the Chinese Self-Directed Search (1994 Edition)

    Science.gov (United States)

    Yang, Weiwei; Lance, Charles E.; Hui, Harry C.

    2006-01-01

    In this study, we (a) examined the measurement equivalence/invariance (ME/I) of the Chinese Self-Directed Search (SDS; 1994 edition) across gender and geographic regions (Mainland China vs. Hong Kong); (b) assessed the construct validity of the Chinese SDS using Widaman's (1985, 1992) MTMM framework; and (c) determined whether vocational interests…

  16. Bibliography of Fynbos ecology: 2nd edition

    CSIR Research Space (South Africa)

    Manders, PT

    1989-12-01

    Full Text Available The first edition of a bibliography of fynbos ecology was produced in 1981 and comprised 814 references to work completed or commenced prior to the initiation of the Fynbos Biome Project. It is appropriate that this second edition...

  17. The Technique of Editing 16mm. Films.

    Science.gov (United States)

    Burder, John

    For professionals and advanced amateurs, this book covers all aspects of editing 16 millimeter film. Beginning with basic matters of film gauge, equipment, and editing facilities, it covers the mechanics of the subject using a how-to-do-it approach. The techniques discussed include preparation of the sound track, cutting, mixing, choice of pace…

  18. Site-specific photochemical RNA editing.

    Science.gov (United States)

    Fujimoto, Kenzo; Konishi-Hiratsuka, Kaoru; Sakamoto, Takashi; Yoshimura, Yoshinaga

    2010-10-28

    Photo-induced artificial RNA editing was demonstrated using photo-reactive oligonucleotides containing 3-cyanovinylcarbazole nucleoside. This non-enzymatic and sequence-specific methodology will make a major contribution to the elucidation of RNA functions including non-coding RNAs and to the development of drugs based on sequence-specific RNA editing.

  19. The Aldine Edition of Aristotle's De Sensu

    DEFF Research Database (Denmark)

    Bloch, David Kristian

    2006-01-01

    This small article examines the quality of and the textual foundation for the først printed edition ever of Aristotle's De Sensu et Sensibilibus, that is, Aldus Manutius' (1497).......This small article examines the quality of and the textual foundation for the først printed edition ever of Aristotle's De Sensu et Sensibilibus, that is, Aldus Manutius' (1497)....

  20. Sex Differences in Cognitive Abilities. Fourth Edition

    Science.gov (United States)

    Halpern, Diane F.

    2011-01-01

    The fourth edition of "Sex Differences in Cognitive Abilities" critically examines the breadth of research on this complex and controversial topic, with the principal aim of helping the reader to understand where sex differences are found--and where they are not. Since the publication of the third edition, there have been many exciting and…

  1. [Tale nucleases--new tool for genome editing].

    Science.gov (United States)

    Glazkova, D V; Shipulin, G A

    2014-01-01

    The ability to introduce targeted changes in the genome of living cells or entire organisms enables researchers to meet the challenges of basic life sciences, biotechnology and medicine. Knockdown of target genes in the zygotes gives the opportunity to investigate the functions of these genes in different organisms. Replacement of single nucleotide in the DNA sequence allows to correct mutations in genes and thus to cure hereditary diseases. Adding transgene to specific genomic.loci can be used in biotechnology for generation of organisms with certain properties or cell lines for biopharmaceutical production. Such manipulations of gene sequences in their natural chromosomal context became possible after the emergence of the technology called "genome editing". This technology is based on the induction of a double-strand break in a specific genomic target DNA using endonucleases that recognize the unique sequences in the genome and on subsequent recovery of DNA integrity through the use of cellular repair mechanisms. A necessary tool for the genome editing is a custom-designed endonuclease which is able to recognize selected sequences. The emergence of a new type of programmable endonucleases, which were constructed on the basis of bacterial proteins--TAL-effectors (Transcription activators like effector), has become an important stage in the development of technology and promoted wide spread of the genome editing. This article reviews the history of the discovery of TAL effectors and creation of TALE nucleases, and describes their advantages over zinc finger endonucleases that appeared earlier. A large section is devoted to description of genetic modifications that can be performed using the genome editing.

  2. Central pontine myelinolysis presenting as isolated sixth nerve palsy in third trimester of pregnancy

    Directory of Open Access Journals (Sweden)

    Tushar Divakar Gosavi

    2015-01-01

    Full Text Available A 30-year-old primigravida presented with isolated left sixth nerve palsy at 38 weeks gestation. Her MRI showed a lesion consistent with central pontine myelinolysis (CPM. Extensive investigations did not reveal any secondary cause for the CPM. She recovered spontaneously in 2 weeks with complete resolution of her MRI changes. To our knowledge, this is the first report of CPM occurring in third trimester in the absence of identifiable secondary causes and of CPM presenting as an isolated sixth nerve palsy. We discuss the reported causes of CPM in pregnancy, possible pathophysiologic mechanisms involved and the anatomic basis of the unique clinical presentation of sixth nerve palsy in our case.

  3. Isolated unilateral sixth cranial nerve palsy: A rare presentation of dengue fever

    Directory of Open Access Journals (Sweden)

    Yang Liang Boo

    2016-11-01

    Full Text Available Dengue fever is a common mosquito-borne viral infection endemic in tropical and subtropical countries. Neurological manifestations in dengue infection are relatively uncommon, and include encephalitis, encephalopathy, neuromuscular disorders and neuro-ocular disorders. Cranial mononeuropathy is a rare manifestation of dengue infection. A 40-year-old man was diagnosed with isolated, unilateral sixth cranial nerve palsy complicating dengue infection. The patient was managed accordingly, and full ocular recovery was observed. This was the first reported case of isolated sixth cranial nerve palsy associated with dengue fever in Malaysia. It is important for clinicians to consider dengue as a differential diagnosis in patients presenting with fever and sixth cranial nerve palsy.

  4. Superior rectus transposition and medial rectus recession for Duane syndrome and sixth nerve palsy.

    Science.gov (United States)

    Mehendale, Reshma A; Dagi, Linda R; Wu, Carolyn; Ledoux, Danielle; Johnston, Suzanne; Hunter, David G

    2012-02-01

    To describe our results using augmented temporal superior rectus transposition (SRT) with adjustable medial rectus muscle recession (MRc) for treatment of Duane syndrome and sixth nerve palsy. Retrospective surgical case review of patients undergoing SRT. Preoperative and postoperative orthoptic measurements were recorded. Minimum follow-up was 6 weeks. Main outcome measures included the angle of esotropia in the primary position and the angle of head turn. Secondary outcomes included duction limitation, stereopsis, and new vertical deviations. The review identified 17 patients: 10 with Duane syndrome and 7 with sixth nerve palsy. Combining SRT with MRc improved esotropia from 44 to 10 prism diopters (P sixth nerve palsy and none with Duane syndrome. No patient described torsional diplopia. Superior rectus transposition allows for the option of simultaneous MRc in patients with severe abduction imitation who require transposition surgery. Combining SRT and MRc improved esotropia, head position, abduction limitation, and stereopsis without inducing torsional diplopia.

  5. [Successful treatment with intravenous steroid pulse therapy of a boy with recurrent idiopathic sixth nerve palsy].

    Science.gov (United States)

    Yamada, Keitaro; Kimizu, Tomokazu; Kimura, Sadami; Ikeda, Tae; Mogami, Yukiko; Yanagihara, Keiko; Suzuki, Yasuhiro

    2014-07-01

    A 3-year-old boy developed left-sided convergent strabismus one week after upper respiratory infection. All examinations, including analysis of cerebrospinal fluid, a tensilon test, and brain MRI, were negative. He was diagnosed with idiopathic sixth nerve palsy. His symptom resolved gradually with vitamin B12, and remitted completely three months after onset. At the age of 6 years, he experienced recurrence of left-sided sixth nerve palsy. After vitamin B12 failed, his symptom responded markedly to intravenous steroid pulse therapy starting on day 26 after relapse. He has been symptom-free for three years since the second remission. Steroid therapy might be effective, and should be considered in children with idiopathic sixth nerve palsy who do not show spontaneous remission.

  6. Evaluation and Estimation of the Provincial Infant Mortality Rate in China's Sixth Census.

    Science.gov (United States)

    Hu, Song Bo; Wang, Fang; Yu, Chuan Hua

    2015-06-01

    To assess the data quality and estimate the provincial infant mortality rate (1q0) from China's sixth census. A log-quadratic model is applied to under-fifteen data. We analyze and compare the average relative errors (AREs) for 1q0 between the estimated and reported values using the leave-one-out cross-validation method. For the sixth census, the AREs are more than 100% for almost all provinces. The estimated average 1q0 level for 31 provinces is 12.3‰ for males and 10.7‰ for females. The data for the provincial 1q0 from China's sixth census have a serious data quality problem. The actual levels of 1q0 for each province are significantly higher than the reported values. Copyright © 2015 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

  7. Enhancing Wikipedia Editing with WAI-ARIA

    Science.gov (United States)

    Senette, Caterina; Buzzi, Maria Claudia; Buzzi, Marina; Leporini, Barbara

    Nowadays Web 2.0 applications allow anyone to create, share and edit on-line content, but accessibility and usability issues still exist. For instance, Wikipedia presents many difficulties for blind users, especially when they want to write or edit articles. In a previous stage of our study we proposed and discussed how to apply the W3C ARIA suite to simplify the Wikipedia editing page when interacting via screen reader. In this paper we present the results of a user test involving totally blind end-users as they interacted with both the original and the modified Wikipedia editing pages. Specifically, the purpose of the test was to compare the editing and formatting process for original and ARIA-implemented Wikipedia user interfaces, and to evaluate the improvements.

  8. Fuel Cell Handbook, Fifth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Energy and Environmental Solutions

    2000-10-31

    Progress continues in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in November 1998. Uppermost, polymer electrolyte fuel cells, molten carbonate fuel cells, and solid oxide fuel cells have been demonstrated at commercial size in power plants. The previously demonstrated phosphoric acid fuel cells have entered the marketplace with more than 220 power plants delivered. Highlighting this commercial entry, the phosphoric acid power plant fleet has demonstrated 95+% availability and several units have passed 40,000 hours of operation. One unit has operated over 49,000 hours. Early expectations of very low emissions and relatively high efficiencies have been met in power plants with each type of fuel cell. Fuel flexibility has been demonstrated using natural gas, propane, landfill gas, anaerobic digester gas, military logistic fuels, and coal gas, greatly expanding market opportunities. Transportation markets worldwide have shown remarkable interest in fuel cells; nearly every major vehicle manufacturer in the U.S., Europe, and the Far East is supporting development. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultrahigh efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 8 describe the six major fuel cell types and their performance based on cell operating conditions. Alkaline and intermediate solid state fuel cells were added to this edition of the Handbook. New information indicates that manufacturers have stayed

  9. Hilbert's sixth problem and the failure of the Boltzmann to Euler limit.

    Science.gov (United States)

    Slemrod, Marshall

    2018-04-28

    This paper addresses the main issue of Hilbert's sixth problem, namely the rigorous passage of solutions to the mesoscopic Boltzmann equation to macroscopic solutions of the Euler equations of compressible gas dynamics. The results of the paper are that (i) in general Hilbert's program will fail because of the appearance of van der Waals-Korteweg capillarity terms in a macroscopic description of motion of a gas, and (ii) the van der Waals-Korteweg theory itself might satisfy Hilbert's quest for a map from the 'atomistic view' to the laws of motion of continua.This article is part of the theme issue 'Hilbert's sixth problem'. © 2018 The Author(s).

  10. A home-based prevention program for sixth-grade alcohol use: Results from project Northland.

    Science.gov (United States)

    Williams, C L; Perry, C L; Dudovitz, B; Veblen-Mortenson, S; Anstine, P S; Komro, K A; Toomey, T L

    1995-12-01

    Project Northland is designed to prevent alcohol use among young adolescents. The project is ongoing in 24 school districts, randomly assigned to intervention or reference conditions. Multiple interventions begin with sixth graders and continue through eighth grade. The reference districts offer their standard health curricula. Evaluation consists of school surveys with the cohort (N = 2201) and telephone surveys of half their parents. This article describes the sixth-grade home-based intervention, the Slick Tracy Home Team. Findings of broad-based participation across sex, race, and risk status were documented, as well as some increases in knowledge and family communication about alcohol use.

  11. Herpes Zoster Ophthalmicus With Sixth Cranial Nerve Palsy: A Case Report

    Directory of Open Access Journals (Sweden)

    Kemal Balcı

    2008-10-01

    Full Text Available Scientific BACKGROUND: Herpes zoster ophthalmicus represents aproximately 25% of all zoster infections. However extraocular gaze palsy in association with herpes zoster infection is extremely rare. OBJECTIVE: We presented here a patient who had herpes zoster ophthalmicus with sixth cranial nerve palsy. CASE: The sixty year old patient had suffered from left retroorbital pain, conjunctival congestion and rashes on the left forehead and the nose and developed ipsilateral sixth cranial nerve palsy. RESULT: Herpes zoster virus infection should be taken into consideration in patients with extraocular paralysis and early treatment may prevent such complications

  12. Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing.

    Science.gov (United States)

    Mout, Rubul; Ray, Moumita; Yesilbag Tonga, Gulen; Lee, Yi-Wei; Tay, Tristan; Sasaki, Kanae; Rotello, Vincent M

    2017-03-28

    Genome editing through the delivery of CRISPR/Cas9-ribonucleoprotein (Cas9-RNP) reduces unwanted gene targeting and avoids integrational mutagenesis that can occur through gene delivery strategies. Direct and efficient delivery of Cas9-RNP into the cytosol followed by translocation to the nucleus remains a challenge. Here, we report a remarkably highly efficient (∼90%) direct cytoplasmic/nuclear delivery of Cas9 protein complexed with a guide RNA (sgRNA) through the coengineering of Cas9 protein and carrier nanoparticles. This construct provides effective (∼30%) gene editing efficiency and opens up opportunities in studying genome dynamics.

  13. Performers, Composers, Scores and Editions: Commentary on Huisman, Gingras, Dhondt, and Leman (2017

    Directory of Open Access Journals (Sweden)

    Dorottya Fabian

    2017-09-01

    Full Text Available Reflecting on a study that examines the impact of various editions on the speed of learning and performance errors, this short paper notes the crudeness of western music notation and how musicians cope with deciphering the composer's musical intentions. Drawing on parallels with practitioners who specialize in historically informed performance and tend to favor playing from manuscripts and facsimiles, I argue that although performing editions are useful, proper education regarding the meaning of notation practices and compositional styles might better serve musicians. This enables each generation to construct its own understanding of the music, and of the contradictory and insufficiently specified demands of the score.

  14. Does atlas-based autosegmentation of neck levels require subsequent manual contour editing to avoid risk of severe target underdosage? A dosimetric analysis

    International Nuclear Information System (INIS)

    Voet, Peter W.J.; Dirkx, Maarten L.P.; Teguh, David N.; Hoogeman, Mischa S.; Levendag, Peter C.; Heijmen, Ben J.M.

    2011-01-01

    Background and purpose: To investigate the dosimetric impact of not editing auto-contours of the elective neck and organs at risk (OAR), generated with atlas-based autosegmentation (ABAS) (Elekta software) for head and neck cancer patients. Materials and methods: For nine patients ABAS auto-contours and auto-contours edited by two observers were available. Based on the non-edited auto-contours clinically acceptable IMRT plans were constructed (designated 'ABAS plans'). These plans were then evaluated for the two edited structure sets, by quantifying the percentage of the neck-PTV receiving more than 95% of the prescribed dose (V 95 ) and the near-minimum dose (D 99 ) in the neck PTV. Dice coefficients and mean contour distances were calculated to quantify the similarity of ABAS auto-contours with the structure sets edited by observer 1 and observer 2. To study the dosimetric importance of editing OAR auto-contours a new IMRT plan was generated for each patient-observer combination, based on the observer's edited CTV and the non-edited salivary gland auto-contours. For each plan mean doses for the non-edited glands were compared with doses for the same glands edited by the observer. Results: For both observers, edited neck CTVs were larger than ABAS auto-contours (p ≤ 0.04), by a mean of 8.7%. When evaluating ABAS plans on the PTVs of the edited structure sets, V 95 reduced by 7.2% ± 5.4% (1 SD) (p 99 was 14.2 Gy (range 1-54 Gy). Even for Dice coefficients >0.8 and mean contour distances 99 up to 11 Gy were observed. For treatment plans based on observer PTVs and non-edited auto-contoured salivary glands, the mean doses in the edited glands differed by only -0.6 Gy ± 1.0 Gy (p = 0.06). Conclusions: Editing of auto-contoured neck CTVs generated by ABAS is required to avoid large underdosages in target volumes. Often used similarity measures for evaluation of auto-contouring algorithms, such as dice coefficients, do not predict well for expected PTV underdose

  15. Genome edited animals: Learning from GM crops?

    Science.gov (United States)

    Bruce, Ann

    2017-06-01

    Genome editing of livestock is poised to become commercial reality, yet questions remain as to appropriate regulation, potential impact on the industry sector and public acceptability of products. This paper looks at how genome editing of livestock has attempted to learn some of the lessons from commercialisation of GM crops, and takes a systemic approach to explore some of the complexity and ambiguity in incorporating genome edited animals in a food production system. Current applications of genome editing are considered, viewed from the perspective of past technological applications. The question of what is genome editing, and can it be considered natural is examined. The implications of regulation on development of different sectors of livestock production systems are studied, with a particular focus on the veterinary sector. From an EU perspective, regulation of genome edited animals, although not necessarily the same as for GM crops, is advocated from a number of different perspectives. This paper aims to open up new avenues of research on genome edited animals, extending from the current primary focus on science and regulation, to engage with a wider-range of food system actors.

  16. Construction practice

    International Nuclear Information System (INIS)

    Winters, J.; Clelland, J.; Rumble, E.; Sandell, L.

    2007-01-01

    One has elaborated a virtual computer model (VRC) of construction of the AP1000 project reactor to demonstrate its viability, to improve the NPP project making it more easy for construction with simultaneous reduction of time, costs and risk of construction. The approach ensured time sequence of the 3-D visualization of NPP at the construction stages. The VRC ensures optimization of scheme implementation time period and specifies the basic costs. The VRC application offers essential advantages when planning construction of a nuclear power facility [ru

  17. Physical Activity of Fifth to Sixth Graders during School Hours According to School Race/Ethnicity: Suburban Cook County, Illinois

    Science.gov (United States)

    Kwon, Soyang; Mason, Maryann; Welch, Sarah

    2015-01-01

    Background: We compared moderate-to-vigorous intensity physical activity (MVPA) and inactivity levels among fifth and sixth graders during school hours according to school-level race/ethnicity and income attributes to inform school-based obesity interventions in Illinois Suburban Cook County (SCC). Methods: Fifth- and sixth-grade students…

  18. A Case Study on the Spatial Conceptualization Abilities for Sixth Grade Elementary Students from Urban, Suburban and Remote Schools

    Science.gov (United States)

    Chao, Jen Yi; Liu, Chuan Hsi

    2017-01-01

    The main objective of this study was to investigate and compare the spatial conceptualization performance for sixth grade elementary school students from urban, suburban and remote schools in Taiwan. This study involved 27, 25, and 26 sixth grade students from one remote indigenous school in eastern Taiwan, one suburban indigenous school in…

  19. Effects of formative assessments to develop self-regulation among sixth grade students: Results from a randomized controlled intervention

    NARCIS (Netherlands)

    Meusen-Beekman, Kelly; Joosten-ten Brinke, Desirée; Boshuizen, Els

    2018-01-01

    This article presents the results of a formative assessment intervention in writing assignments in sixth grade. We examined whether formative assessments would improve self-regulation, motivation and self-efficacy among sixth graders, and whether differential effects exist between formative

  20. Statics of historic masonry constructions

    CERN Document Server

    Como, Mario

    2017-01-01

    Masonry constructions are the great majority of the buildings in Europe’s historic centres and the most important monuments of its architectural heritage. Given the age of these constructions, the demand for safety assessments and restoration projects is pressing and constant; still within the broad studies in the subject it is not yet recognised, in particular within the seismic area, a unitary approach to deal with Masonry structures. This successful book contributes to clarify the issues with a rigorous approach offering a comprehensive new Statics of Masonry Constructions. This third edition has been driven by some recent developments of the research in the field, and it gives the fundamentals of Statics with an original and rigorous mathematical formulation, further in-depth inquired in this new version. With many refinements and improvements, the book investigates the static behaviour of many historic monuments, such as the Gothic Cathedrals, the Mycenaean Tholoi, the Pantheon, the Colosseum, the dome...

  1. The Break-In at Skool-Kem: Forensic Science for Fifth and Sixth Graders.

    Science.gov (United States)

    Dickie, Sue; Percival, Stan

    1986-01-01

    Explains how a Forensic Science and Criminology unit can help in the development of science process skills, mastery of laboratory techniques, and assist in value clarification. Examples of investigations and activities that have been successful with fifth- and sixth-grade students are included. (ML)

  2. The Influences of the Sixth Graders' Parents' Internet Literacy and Parenting Style on Internet Parenting

    Science.gov (United States)

    Lou, Shi-Jer; Shih, Ru-Chu; Liu, Hung-Tzu; Guo, Yuan-Chang; Tseng, Kuo-Hung

    2010-01-01

    This study aims to explore the sixth grade students' parents' Internet literacy and parenting style on Internet parenting in Kaohsiung County in Taiwan. Upon stratified cluster sampling, a total of 822 parents from 34 classes in 28 schools participated in this study. The descriptive statistics and chi-square test were used to analyze the responses…

  3. Raising Self-Esteem and Preventing Drug Abuse among Sixth Graders: Effects of an Adventure Experience.

    Science.gov (United States)

    Cason, Dana R; And Others

    1993-01-01

    Describes the effects of Camp DETOUR, an adventure experience program for sixth-grade students at a Georgia middle school. Program goals were improvement of student self-esteem as a component of drug abuse prevention and improvement of student behavior. The program was shown to have positive effects on student self-esteem. This result may deter…

  4. Negotiating Discourses: Sixth-Grade Students' Use of Multiple Science Discourses during a Science Fair Presentation

    Science.gov (United States)

    Gomez, Kimberley

    2007-01-01

    This study offers important insights into the coexistence of multiple discourses and the link between these discourses and science understanding. It offers concrete examples of students' movement between multiple discourses in sixth-grade science fair presentations, and shows how those multiple discourses in science practices illuminate students'…

  5. Self-Perception of Advanced Mathematical Learners: A Focus on Sixth-Grade Latinos/as

    Science.gov (United States)

    Cavell, Heather A.

    2010-01-01

    The purpose of this dissertation was to analyze the social and educational contexts that impact students' perceptions of their mathematical learning and students' use of resistance in regard to these social and educational impacts within the sixth grade environment. Specifically, this study addressed the following overarching questions: (1) What…

  6. An Analysis of Global Problems Issues in Sixth and Seventh Grade Science Textbooks.

    Science.gov (United States)

    Hamm, Mary; Adams, Dennis

    The study examines the extent to which the global issues of population growth, world hunger, air quality and atmosphere, and water resources were treated in sixth and seventh grade science textbooks. Ten textbooks were examined by five raters to determine the amount of content presented by different textbooks on global issues, the number of pages…

  7. An Evaluation of the Cooperative Learning Process by Sixth-Grade Students

    Science.gov (United States)

    Genç, Murat

    2016-01-01

    The purpose of this study is to investigate the effectiveness of cooperative learning on the science lessons achievement of primary school students and to designate their views on cooperative learning process. 135 sixth-grade students attending the same school took part in the study. The model of this study was the Solomon four-group model. In the…

  8. Does It Add up? Calculators as Accommodations for Sixth Grade Students with Disabilities

    Science.gov (United States)

    Bouck, Emily C.; Bouck, Mary K.

    2009-01-01

    This study explored the performance of sixth grade students with and without disabilities on a mathematics assessment aligned to state standards when provided a calculator as an accommodation. The study utilized a pre/posttest design. No student was given access to a calculator on the pretest, and approximately half of the students were randomly…

  9. Children's Perceptions of Parental Attitude Affecting Breakfast Skipping in Primary Sixth-Grade Students

    Science.gov (United States)

    Cheng, Tereza Sy; Tse, Lap Ah; Yu, Ignatius Tak-Sun; Griffiths, Sian

    2008-01-01

    Background: Breakfast skipping is an international public health concern. This study investigated the prevalence of breakfast skipping among primary sixth-grade students in Hong Kong and the impact of students' perceptions of parental attitudes on breakfast skipping. Methods: A total of 426 students aged 10-14 years in 4 local schools participated…

  10. Sixth Grade Students Who Use Alcohol: Do We Need Primary Prevention Programs for "Tweens"?

    Science.gov (United States)

    Pasch, Keryn E.; Perry, Cheryl L.; Stigler, Melissa H.; Komro, Kelli A.

    2009-01-01

    Young adolescent alcohol users drink at higher rates than their peers throughout adolescence and appear to be less amenable to intervention. This study compares those who reported alcohol use in the past year to those who reported no use in a multiethnic, urban sample of sixth graders in 61 schools in Chicago in 2002 (N = 4,150). Demographic,…

  11. The sixth Nordic conference on the application of scientific methods in archaeology

    International Nuclear Information System (INIS)

    1993-01-01

    The Sixth Nordic Conference on the Application of Scientific Methods in Archaeology with 73 participants was convened in Esbjerg (Denmark), 19-23 September 1993. Isotope dating of archaeological, paleoecological and geochronological objects, neutron activation and XRF analytical methods, magnetometry, thermoluminescence etc. have been discussed. The program included excursions to archaeological sites and a poster session with 12 posters. (EG)

  12. Developing Mass, Volume, and Density as Mediational Means in a Sixth Grade Classroom.

    Science.gov (United States)

    Vellom, R. Paul; Anderson, Charles W.; Palincsar, Annemarie S.

    This study examines thought, language, and related action in sixth-graders working to understand concepts related to mass, volume, and density. Students from a heterogeneous urban classroom worked in various social contexts including individually, in pairs, in groups of four, and as a class. Their work was examined via videotapes, field notes,…

  13. Teaching Archimedes' Principle to Sixth Graders without Teaching Mass, Density, Pressure, Volume or Buoyancy

    Science.gov (United States)

    Raghavan, Neeraja

    2017-01-01

    Flotation is usually taught in Indian schools after students have been introduced to the concepts of mass, density, pressure, volume and buoyancy. This paper describes an attempt to teach the principle of flotation to a class of sixth graders--who had not yet been taught these concepts--so they could understand (and perhaps, arrive at) Archimedes'…

  14. Blow-Up of Solutions for a Class of Sixth Order Nonlinear Strongly Damped Wave Equation

    Directory of Open Access Journals (Sweden)

    Huafei Di

    2014-01-01

    Full Text Available We consider the blow-up phenomenon of sixth order nonlinear strongly damped wave equation. By using the concavity method, we prove a finite time blow-up result under assumptions on the nonlinear term and the initial data.

  15. Clinical features and natural history of acquired third, fourth, and sixth cranial nerve palsy.

    Science.gov (United States)

    Park, U-C; Kim, S-J; Hwang, J-M; Yu, Y S

    2008-05-01

    Clinical features of acquired third, fourth, and sixth cranial nerve palsy showed variation among previous studies. Evaluation of natural course with objective criteria will establish accurate recovery rates and important factors for recovery. Retrospective chart review was performed on 206 patients who visited a neuro-ophthalmic department with acquired third, fourth, and sixth nerve palsy. Aetiology and results of ocular exam on each visit were reviewed, and multivariate logistic regression analysis was performed to identify independent factors affecting recovery. The sixth cranial nerve was affected most frequently (n=108, 52.4%) and vascular disease (n=64, 31.1%) was the most common aetiology. Recovery was evaluated with change of deviation angle for 108 patients, who were first examined within a month of onset and followed up for at least 6 months. Ninety-two (85.2%) patients showed overall (at least partial) recovery and 73 (67.6%) showed complete recovery. In univariate analysis, initial deviation angle was found to be only significant factor associated with complete recovery (P=0.007) and most patients who experienced successful management of treatable underlying disease showed recovery. With objective criteria based on deviation angle, overall recovery rate from the third, fourth, and sixth nerve palsy was 85.2%. Patients who had smaller initial eyeball deviation or successful management of treatable underlying disease had a high chance of recovery.

  16. Idiopathic sixth nerve palsy after bimaxillary surgery: a complication or a sequential pathology independent from surgery?

    Science.gov (United States)

    Şirinoğlu, Hakan; Güvercin, Emre; Çakmakoğlu, Çağri; Filinte, Gaye Taylan; Yeşiloğlu, Nebil; Bozkurt, Mehmet

    2015-01-01

    This was a case of a 21-year-old female patient with a very rare and unexpected symptom "diplopia occurring due to the idiopathic sixth nerve palsy" encountered after 2 weeks following bimaxillary surgery performed for the correction of class III malocclusion deformity.

  17. Causes and treatment outcomes of third, fourth and sixth cranial nerve palsy.

    Science.gov (United States)

    Surachatkumtonekul, Thammanoon; Soontrapa, Pennapa; Kampanartsanyakorn, Suchada; Dulayajinda, Dhaivadee

    2012-04-01

    To evaluate the causes and the treatment outcomes of third, fourth and sixth cranial nerve palsy Medical records of 157 cases with extra-ocular muscle palsy from third, fourth or sixth cranial nerve palsy between January 1995 and December 2009 were reviewed. Demographic data, age, causes of extra-ocular muscle palsy and treatment outcomes were record and analyzed. The patients who were followed-up less than 6 months, myasthenia gravis and extra-ocular muscles fibrosis were excluded from the present study. One hundred and fifty-seven cases from 600 cases were included in the present study. The most common cranial nerve palsy was the sixth cranial nerve with 63 cases (40.1%). Of 157 cases, the causes were trauma 41 cases (26.1%), microvascular occlusion cause 34 cases (21.7%) and congenital cause 21 cases (13.4%). Cranial nerve palsy patients from microvascular occlusion cause spontaneously improved 25 of 34 cases (73.50%) in 6 months. All patients (21 cases)from congenital cranial nerve palsy had extra-ocular muscle surgery and 17 patients (80.9%) were successful. Sixth cranial nerve palsy was the most common cranial nerve palsy. Most patients with cranial nerve palsy from vascular cause spontaneously improved in 6 months. Congenital cranial nerve palsy patients need extra-ocular muscle surgery and most cases were successful

  18. Judeans in Babylonia : a study of deportees in the Sixth and Fifth Centuries BCE

    NARCIS (Netherlands)

    Tero, Alstola

    2017-01-01

    This dissertation investigates the life of Judean deportees in Babylonia in the sixth and fifth centuries BCE. The results from the study of Judeans are placed in the wider context of Babylonian society and are evaluated by using a group of Neirabian deportees as a point of comparison. The

  19. From holes to huts: reconstructing an extinct type of architecture at the Sixth Nile Cataract

    Czech Academy of Sciences Publication Activity Database

    Varadzin, Ladislav; Varadzinová, L.; Pacina, J.

    2017-01-01

    Roč. 91, č. 357 (2017), s. 589-604 ISSN 0003-598X Institutional support: RVO:67985912 Keywords : North Africa * Sudan * Sixth Nile Cataract * Mesolithic * architecture * drilled holes Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Archaeology Impact factor: 1.536, year: 2016

  20. Effects of Cooperative Learning on the Performance of Sixth-Grade Physical Education Students

    Science.gov (United States)

    Barrett, Tim

    2005-01-01

    The purpose of this investigation was to assess the effects of a cooperative learning strategy in physical education on academic learning time, the percentage of correct trials, the total number of trials, and the number of correct trials. A cooperative learning strategy, PACER (Performer and Coach Earn Rewards), was implemented in a sixth-grade…

  1. Evaluating Fifth- and Sixth-Grade Students' Expository Writing: Task Development, Scoring, and Psychometric Issues

    Science.gov (United States)

    Kulikowich, Jonna M.; Mason, Linda H.; Brown, Scott W.

    2008-01-01

    Drawing from multiple theoretical frameworks representing cognitive and educational psychology, we present a writing task and scoring system for measurement of students' informative writing. Participants in this study were 72 fifth- and sixth-grade students who wrote compositions describing real-world problems and how mathematics, science, and…

  2. The sixth seal in Revelation 6:12-17 | de Villiers | Acta Theologica

    African Journals Online (AJOL)

    In an introduction the nature and role of a close reading in Biblical Studies is briefly outlined. A second part analyses the form of the sixth seal and indicates what and how literary techniques were used to compose the text. These are then in turn investigated to explain the meaning and function of this seal within the ...

  3. Derivational Morphological Awareness, Academic Vocabulary, and Reading Comprehension in Linguistically Diverse Sixth Graders

    Science.gov (United States)

    Kieffer, Michael J.; Box, Catherine DiFelice

    2013-01-01

    This study investigated the multiple roles of morphological awareness in reading comprehension for Spanish-speaking language minority (LM) learners and their native English-speaking (NE) peers. Sixth-grade students (N = 137; 82 LM, 55 NE) were assessed on English measures of derivational morphological awareness, morphologically complex academic…

  4. Distributing Leadership in English Sixth Form Colleges: Liberation or Another Form of Managerial Control?

    Science.gov (United States)

    Stoten, David William

    2015-01-01

    Purpose: The purpose of this paper is to explore the distribution of leadership practices in Sixth Form Colleges (SFCs). This is an area where very little research has been undertaken and the intention was to investigate the topic from a critical perspective using social constructionist methodology. Design/methodology/approach: The research…

  5. The Thumbs Up Ecology Curriculum: A Fun Group of School Site Activities for Sixth Graders.

    Science.gov (United States)

    Smith, John; And Others

    This guide is a collection of "fun" school site activities for sixth graders. Some of the topics covered are: animals, trees, energy and lifestyle, land use and you, energy conservation, and car-pooling. Each section offers both introductory information about the topic as well as questions to ponder such as what, so what, now what, and another way…

  6. Proceedings of the sixth international symposium on methodologies for intelligent systems (Poster Session)

    Energy Technology Data Exchange (ETDEWEB)

    Harber, K.S. (ed.)

    1991-09-01

    This volume contains papers which have been selected for the poster Session at the Sixth International Symposium for Intelligent Systems held October 1991, The following major areas were covered: expert systems; intelligent databases; knowledge representation; learning and adaptive systems; and logic for artificial intelligence. Nineteen full papers are included. (GHH)

  7. 76 FR 71048 - Sixth Annual Philip S. Chen, Jr. Distinguished Lecture on Innovation and Technology Transfer

    Science.gov (United States)

    2011-11-16

    ..., Jr. Distinguished Lecture on Innovation and Technology Transfer AGENCY: National Institutes of Health... sixth annual Philip S. Chen, Jr., Ph.D. Distinguished Lecture on Innovation and Technology Transfer... present ``Treatment of Cancer with Recombinant Immunotoxins: From Technology Transfer to the Patient.'' Dr...

  8. Diabetes and hypertension in isolated sixth nerve palsy: a population-based study.

    Science.gov (United States)

    Patel, Sanjay V; Holmes, Jonathan M; Hodge, David O; Burke, James P

    2005-05-01

    Diabetes mellitus and systemic hypertension are frequently reported as ischemic causes of sixth nerve palsy/paresis, but there are few rigorous studies to support these associations. We conducted a population-based case-control study to determine the presence and magnitude of any association of preexisting diabetes mellitus and systemic hypertension with isolated sixth nerve palsy. Retrospective population-based case-control study. Participants were patients with new onset of neurologically isolated sixth nerve palsy or paresis (n = 76) in Olmsted County, Minnesota, from January 1, 1978, to December 31, 1992. Controls (n = 76) were selected from the same general population and were matched for age, gender, and length of medical follow-up. Using the Rochester Epidemiology Project medical records linkage system, which captures virtually all medical care provided to residents of Olmsted County, Minnesota, we identified all incident cases of neurologically isolated sixth nerve palsy/paresis (n = 76) among county residents between the given dates. An equal number (n = 76) of controls were randomly selected from the general population. We reviewed the entire medical record of each case and control, using stringent predetermined criteria to define the presence of diabetes mellitus and systemic hypertension. We compared the prevalence of diabetes and systemic hypertension between cases and controls by use of chi-square tests, and we calculated odds ratios (OR) with 95% confidence intervals (CI). Presence or absence of diabetes mellitus and systemic hypertension. Diabetes mellitus occurred more frequently in cases (23.7%) than in controls (5.3%; P = 0.001; OR, 5.59; 95% CI, 1.79-17.42). Systemic hypertension occurred with similar frequency in cases (51.3%) and controls (39.5%; P = 0.14; OR, 1.62; 95% CI, 0.85-3.08). Coexistent diabetes mellitus and hypertension were more common in cases (18.4%) than in controls (2.6%; P = 0.002; OR, 8.36; 95% CI, 1.83-38.18). We conclude

  9. Improved design of hammerhead ribozyme for selective digestion of target RNA through recognition of site-specific adenosine-to-inosine RNA editing.

    Science.gov (United States)

    Fukuda, Masatora; Kurihara, Kei; Yamaguchi, Shota; Oyama, Yui; Deshimaru, Masanobu

    2014-03-01

    Adenosine-to-inosine (A-to-I) RNA editing is an endogenous regulatory mechanism involved in various biological processes. Site-specific, editing-state-dependent degradation of target RNA may be a powerful tool both for analyzing the mechanism of RNA editing and for regulating biological processes. Previously, we designed an artificial hammerhead ribozyme (HHR) for selective, site-specific RNA cleavage dependent on the A-to-I RNA editing state. In the present work, we developed an improved strategy for constructing a trans-acting HHR that specifically cleaves target editing sites in the adenosine but not the inosine state. Specificity for unedited sites was achieved by utilizing a sequence encoding the intrinsic cleavage specificity of a natural HHR. We used in vitro selection methods in an HHR library to select for an extended HHR containing a tertiary stabilization motif that facilitates HHR folding into an active conformation. By using this method, we successfully constructed highly active HHRs with unedited-specific cleavage. Moreover, using HHR cleavage followed by direct sequencing, we demonstrated that this ribozyme could cleave serotonin 2C receptor (HTR2C) mRNA extracted from mouse brain, depending on the site-specific editing state. This unedited-specific cleavage also enabled us to analyze the effect of editing state at the E and C sites on editing at other sites by using direct sequencing for the simultaneous quantification of the editing ratio at multiple sites. Our approach has the potential to elucidate the mechanism underlying the interdependencies of different editing states in substrate RNA with multiple editing sites.

  10. Vertical muscle transposition augmented with lateral fixation (Foster) suture for Duane syndrome and sixth nerve palsy.

    Science.gov (United States)

    Akar, S; Gokyigit, B; Pekel, G; Demircan, A; Demirok, A

    2013-10-01

    To report the postoperative results of full-tendon vertical rectus transposition (VRT) augmented with lateral fixation suture for the treatment of type 1 Duane syndrome and sixth nerve palsy and to determine whether there was a decrease in the effect of the Foster suture over time. This retrospective, consecutive case series included patients who underwent a full-tendon VRT transposition with lateral fixation for type 1 Duane syndrome or sixth nerve palsy. The primary outcome measures included deviation, abnormal head posture(AHP), abduction deficiency, and postoperative binocular single visual field (BSVF). Eighty-seven patients (87 eyes: 40 eyes with Duane syndrome and 47 eyes with sixth nerve palsy) were included in this study. In Duane syndrome patients, the deviation was reduced by a mean of 95%, the AHP was eliminated in 86% of patients, the abduction was improved by 42%, and a useful BSVF of ≈ 67% of normal was achieved at 1 year post operation. In sixth nerve palsy patients, the deviation was reduced by 99%, the abduction was improved by 59%, and a useful BSVF of ≈ 71% of normal was achieved at 1 year post operation. In both groups, the improvements in deviation angle and abduction were stable postoperatively. Sixteen patients needed reoperation for undercorrection. VRT surgery with posterior fixation is an effective treatment method for complete sixth nerve palsy and Duane syndrome with esotropia, AHP, and abduction deficiency. The procedure carries a small risk of reoperation for undercorrection. The effect of the Foster suture did not decline over time.

  11. Harnessing type I and type III CRISPR-Cas systems for genome editing

    DEFF Research Database (Denmark)

    Li, Yingjun; Pan, Saifu; Zhang, Yan

    2016-01-01

    CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems are widespread in archaea and bacteria, and research on their molecular mechanisms has led to the development of genome-editing techniques based on a few Type II systems. However, there has not been any...... report on harnessing a Type I or Type III system for genome editing. Here, a method was developed to repurpose both CRISPR-Cas systems for genetic manipulation in Sulfolobus islandicus, a thermophilic archaeon. A novel type of genome-editing plasmid (pGE) was constructed, carrying an artificial mini-CRISPR...... and selectively retained as transformants. Using this strategy, different types of mutation were generated, including deletion, insertion and point mutations. We envision this method is readily applicable to different bacteria and archaea that carry an active CRISPR-Cas system of DNA interference provided...

  12. KWIC Index of nuclear codes (1975 edition)

    International Nuclear Information System (INIS)

    Akanuma, Makoto; Hirakawa, Takashi

    1976-01-01

    It is a KWIC Index for 254 nuclear codes in the Nuclear Code Abstracts (1975 edition). The classification of nuclear codes and the form of index are the same as those in the Computer Programme Library at Ispra, Italy. (auth.)

  13. Specification Editing and Discovery Assistant Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The project will prototype a specification editing and discovery tool (SPEEDY) for C/C++ that will assist software developers with modular formal verification tasks...

  14. A genome editing primer for the hematologist

    Science.gov (United States)

    Hoban, Megan D.

    2016-01-01

    Gene editing enables the site-specific modification of the genome. These technologies have rapidly advanced such that they have entered common use in experimental hematology to investigate genetic function. In addition, genome editing is becoming increasingly plausible as a treatment modality to rectify genetic blood disorders and improve cellular therapies. Genome modification typically ensues from site-specific double-strand breaks and may result in a myriad of outcomes. Even single-strand nicks and targeted biochemical modifications that do not permanently alter the DNA sequence (epigenome editing) may be powerful instruments. In this review, we examine the various technologies, describe their advantages and shortcomings for engendering useful genetic alterations, and consider future prospects for genome editing to impact hematology. PMID:27053532

  15. LabVIEW 8 student edition

    CERN Document Server

    Bishop, Robert H

    2007-01-01

    For courses in Measurement and Instrumentation, Electrical Engineering lab, and Physics and Chemistry lab. This revised printing has been updated to include new LabVIEW 8.2 Student Edition. National Instruments' LabVIEW is the defacto industry standard for test, measurement, and automation software solutions. With the Student Edition of LabVIEW, students can design graphical programming solutions to their classroom problems and laboratory experiments with software that delivers the graphical programming capabilites of the LabVIEW professional version. . The Student Edition is also compatible with all National Instruments data acquisition and instrument control hardware. Note: The LabVIEW Student Edition is available to students, faculty, and staff for personal educational use only. It is not intended for research, institutional, or commercial use. For more information about these licensing options, please visit the National Instruments website at (http:www.ni.com/academic/)

  16. Construction aggregates

    Science.gov (United States)

    Tepordei, V.V.

    1994-01-01

    Part of a special section on industrial minerals in 1993. The 1993 production of construction aggregates increased 6.3 percent over the 1992 figure, to reach 2.01 Gt. This represents the highest estimated annual production of combined crushed stone and construction sand and gravel ever recorded in the U.S. The outlook for construction aggregates and the issues facing the industry are discussed.

  17. FFTF constructibility

    International Nuclear Information System (INIS)

    Weber, S.A.; Hulbert, D.I.

    1975-01-01

    The influence of the design criteria on the constructibility of the Fast Flux Test Facility is described. Specifically, the effects of requirements due to maintenance accessibility, inerting of cells, seismicity, codes, and standards are addressed. The design and construction techniques developed to minimize the impact of the design criteria on cost and schedule are presented with particular emphasis on the cleanliness and humidity controls imposed during construction of the sodium systems. (U.S.)

  18. Introductory physics of nuclear medicine. Third edition

    International Nuclear Information System (INIS)

    Chandra, R.

    1987-01-01

    The new third edition includes essential details and many examples and problems taken from the routine practice of nuclear medicine. Basic principles and underlying concepts are explained, although it is assumed that the reader has some current use as a bone densitometer. For resident physicians in nuclear medicine, residents in pathology, radiology, and internal medicine, and students of nuclear medicine technology, the third edition offers a simplified and reliable approach to the physics and basic sciences of nuclear medicine

  19. Nuclear electronics laboratory manual 1989 edition

    International Nuclear Information System (INIS)

    1989-10-01

    This manual is a joint product of several electronics experts who have been associated with IAEA activity in this field for many years. It is based on the experience of conducting twenty-three training courses on nuclear electronics. Compared with the first edition, published 1984, this edition contains many new experiments, mainly on the advanced technical level. The total number of experiments and special projects is 58. Tabs and figs

  20. Non-GMO genetically edited crop plants.

    Science.gov (United States)

    Kanchiswamy, Chidananda Nagamangala; Malnoy, Mickael; Velasco, Riccardo; Kim, Jin-Soo; Viola, Roberto

    2015-09-01

    Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome editing complex is degraded in the recipient cells. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. The Ethics of Germline Gene Editing

    OpenAIRE

    Gyngell, Christopher; Douglas, Thomas; Savulescu, Julian

    2016-01-01

    Germline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this paper, we analyze the ethical arguments for and against pursuing GGE, which we take to consist in allowing and funding its development. We argue there is a strong case for pursuing GGE for the prevention of disease. We then examine objections that have been raised against pursuing GG...

  2. Genome Editing in Sugarcane: Challenges Ahead

    OpenAIRE

    Mohan, Chakravarthi

    2016-01-01

    Genome editing opens new and unique opportunities for researchers to enhance crop production. Until 2013, the zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) were the key tools used for genome editing applications. The advent of RNA-guided engineered nucleases - the type II clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 (CRISPR-associated) system from Streptococcus pyogenes holds great potential since it is simple, effective an...

  3. A genome editing primer for the hematologist

    OpenAIRE

    Hoban, Megan D.; Bauer, Daniel E.

    2016-01-01

    Gene editing enables the site-specific modification of the genome. These technologies have rapidly advanced such that they have entered common use in experimental hematology to investigate genetic function. In addition, genome editing is becoming increasingly plausible as a treatment modality to rectify genetic blood disorders and improve cellular therapies. Genome modification typically ensues from site-specific double-strand breaks and may result in a myriad of outcomes. Even single-strand ...

  4. Computational Physics - 2nd Edition

    Science.gov (United States)

    Thijssen, J. M.

    1998-11-01

    This second edition describes the computational methods used in theoretical physics, and has been fully updated. New sections have been added to cover finite element methods and lattice Boltzmann simulation, density functional theory, quantum molecular dynamics, Monte Carlo simulation, and diagonalisation of one-dimensional quantum systems. It covers many different areas of physics research and different computational methodologies, including computational methods such as Monte Carlo and molecular dynamics, various electronic structure methodologies, methods for solving partial differential equations, and lattice gauge theory. Throughout the book the relations between the methods used in different fields of physics are emphasised. Several new programs are described and can be downloaded from www.cambridge.org/9780521833462. The book requires a background in elementary programming, numerical analysis, and field theory, as well as undergraduate knowledge on condensed matter theory and statistical physics. It will be of interest to graduate students and researchers in theoretical, computational and experimental physics. Completely revised with new chapters including finite element methods and lattice Boltzmann simulation Describes several new programs which can be downloaded from www.cambridge.org/9780521833462 Contains questions on theory and implementation at the end of each chapter

  5. CRISPR/Cas9-Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development.

    Science.gov (United States)

    Okoli, Arinze; Okeke, Malachy I; Tryland, Morten; Moens, Ugo

    2018-01-22

    The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector Nucleases) and ZFNs (Zinc Finger Nucleases) in genome editing of viruses. CRISPR/Cas9 is presently being applied in constructing viral mutants, preventing virus infections, eradicating proviral DNA, and inhibiting viral replication in infected cells. The successful adaptation of CRISPR/Cas9 to editing the genome of Vaccinia virus paves the way for its application in editing other vaccine/vector-relevant orthopoxvirus (OPXV) strains. Thus, CRISPR/Cas9 can be used to resolve some of the major hindrances to the development of OPXV-based recombinant vaccines and vectors, including sub-optimal immunogenicity; transgene and genome instability; reversion of attenuation; potential of spread of transgenes to wildtype strains and close contacts, which are important biosafety and risk assessment considerations. In this article, we review the published literature on the application of CRISPR/Cas9 in virus genome editing and discuss the potentials of CRISPR/Cas9 in advancing OPXV-based recombinant vaccines and vectors. We also discuss the application of CRISPR/Cas9 in combating viruses of clinical relevance, the limitations of CRISPR/Cas9 and the current strategies to overcome them.

  6. CRISPR/Cas9—Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development

    Science.gov (United States)

    Okoli, Arinze; Okeke, Malachy I.; Tryland, Morten; Moens, Ugo

    2018-01-01

    The clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein 9 (Cas9) technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector Nucleases) and ZFNs (Zinc Finger Nucleases) in genome editing of viruses. CRISPR/Cas9 is presently being applied in constructing viral mutants, preventing virus infections, eradicating proviral DNA, and inhibiting viral replication in infected cells. The successful adaptation of CRISPR/Cas9 to editing the genome of Vaccinia virus paves the way for its application in editing other vaccine/vector-relevant orthopoxvirus (OPXV) strains. Thus, CRISPR/Cas9 can be used to resolve some of the major hindrances to the development of OPXV-based recombinant vaccines and vectors, including sub-optimal immunogenicity; transgene and genome instability; reversion of attenuation; potential of spread of transgenes to wildtype strains and close contacts, which are important biosafety and risk assessment considerations. In this article, we review the published literature on the application of CRISPR/Cas9 in virus genome editing and discuss the potentials of CRISPR/Cas9 in advancing OPXV-based recombinant vaccines and vectors. We also discuss the application of CRISPR/Cas9 in combating viruses of clinical relevance, the limitations of CRISPR/Cas9 and the current strategies to overcome them. PMID:29361752

  7. Applications of genome editing by programmable nucleases to the metabolic engineering of secondary metabolites.

    Science.gov (United States)

    Leitão, Ana Lúcia; Costa, Marina C; Enguita, Francisco J

    2017-01-10

    Genome engineering is a branch of modern biotechnology composed of a cohort of protocols designed to construct and modify a genotype with the main objective of giving rise to a desired phenotype. Conceptually, genome engineering is based on the so called genome editing technologies, a group of genetic techniques that allow either to delete or to insert genetic information in a particular genomic locus. Ten years ago, genome editing tools were limited to virus-driven integration and homologous DNA recombination. However, nowadays the uprising of programmable nucleases is rapidly changing this paradigm. There are two main families of modern tools for genome editing depending on the molecule that controls the specificity of the system and drives the editor machinery to its place of action. Enzymes such as Zn-finger and TALEN nucleases are protein-driven genome editors; while CRISPR system is a nucleic acid-guided editing system. Genome editing techniques are still not widely applied for the design of new compounds with pharmacological activity, but they are starting to be considered as promising tools for rational genome manipulation in biotechnology applications. In this review we will discuss the potential applications of programmable nucleases for the metabolic engineering of secondary metabolites with biological activity. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. CRISPR/Cas9—Advancing Orthopoxvirus Genome Editing for Vaccine and Vector Development

    Directory of Open Access Journals (Sweden)

    Arinze Okoli

    2018-01-01

    Full Text Available The clustered regularly interspaced short palindromic repeat (CRISPR/associated protein 9 (Cas9 technology is revolutionizing genome editing approaches. Its high efficiency, specificity, versatility, flexibility, simplicity and low cost have made the CRISPR/Cas9 system preferable to other guided site-specific nuclease-based systems such as TALENs (Transcription Activator-like Effector Nucleases and ZFNs (Zinc Finger Nucleases in genome editing of viruses. CRISPR/Cas9 is presently being applied in constructing viral mutants, preventing virus infections, eradicating proviral DNA, and inhibiting viral replication in infected cells. The successful adaptation of CRISPR/Cas9 to editing the genome of Vaccinia virus paves the way for its application in editing other vaccine/vector-relevant orthopoxvirus (OPXV strains. Thus, CRISPR/Cas9 can be used to resolve some of the major hindrances to the development of OPXV-based recombinant vaccines and vectors, including sub-optimal immunogenicity; transgene and genome instability; reversion of attenuation; potential of spread of transgenes to wildtype strains and close contacts, which are important biosafety and risk assessment considerations. In this article, we review the published literature on the application of CRISPR/Cas9 in virus genome editing and discuss the potentials of CRISPR/Cas9 in advancing OPXV-based recombinant vaccines and vectors. We also discuss the application of CRISPR/Cas9 in combating viruses of clinical relevance, the limitations of CRISPR/Cas9 and the current strategies to overcome them.

  9. On the evaluation of segmentation editing tools

    Science.gov (United States)

    Heckel, Frank; Moltz, Jan H.; Meine, Hans; Geisler, Benjamin; Kießling, Andreas; D’Anastasi, Melvin; dos Santos, Daniel Pinto; Theruvath, Ashok Joseph; Hahn, Horst K.

    2014-01-01

    Abstract. Efficient segmentation editing tools are important components in the segmentation process, as no automatic methods exist that always generate sufficient results. Evaluating segmentation editing algorithms is challenging, because their quality depends on the user’s subjective impression. So far, no established methods for an objective, comprehensive evaluation of such tools exist and, particularly, intermediate segmentation results are not taken into account. We discuss the evaluation of editing algorithms in the context of tumor segmentation in computed tomography. We propose a rating scheme to qualitatively measure the accuracy and efficiency of editing tools in user studies. In order to objectively summarize the overall quality, we propose two scores based on the subjective rating and the quantified segmentation quality over time. Finally, a simulation-based evaluation approach is discussed, which allows a more reproducible evaluation without the need for human input. This automated evaluation complements user studies, allowing a more convincing evaluation, particularly during development, where frequent user studies are not possible. The proposed methods have been used to evaluate two dedicated editing algorithms on 131 representative tumor segmentations. We show how the comparison of editing algorithms benefits from the proposed methods. Our results also show the correlation of the suggested quality score with the qualitative ratings. PMID:26158063

  10. Genome editing with engineered nucleases in plants.

    Science.gov (United States)

    Osakabe, Yuriko; Osakabe, Keishi

    2015-03-01

    Numerous examples of successful 'genome editing' now exist. Genome editing uses engineered nucleases as powerful tools to target specific DNA sequences to edit genes precisely in the genomes of both model and crop plants, as well as a variety of other organisms. The DNA-binding domains of zinc finger (ZF) proteins were the first to be used as genome editing tools, in the form of designed ZF nucleases (ZFNs). More recently, transcription activator-like effector nucleases (TALENs), as well as the clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9) system, which utilizes RNA-DNA interactions, have proved useful. A key step in genome editing is the generation of a double-stranded DNA break that is specific to the target gene. This is achieved by custom-designed endonucleases, which enable site-directed mutagenesis via a non-homologous end-joining (NHEJ) repair pathway and/or gene targeting via homologous recombination (HR) to occur efficiently at specific sites in the genome. This review provides an overview of recent advances in genome editing technologies in plants, and discusses how these can provide insights into current plant molecular biology research and molecular breeding technology. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  11. Genome editing systems in novel therapies.

    Science.gov (United States)

    Jang, Yoon-Young; Cai, Liuhong; Ye, Zhaohui

    2016-01-01

    Genome editing is the process in which DNA sequences at precise genomic locations are modified. In the past three decades, genome editing by homologous recombination has been successfully performed in mouse for generating genetic models. The low efficiency of this process in human cells, however, had prevented its clinical application until the recent advancements in designer endonuclease technologies. The significantly improved genome editing efficiencies aided by ZFN, TALEN, and CRISPR systems provide unprecedented opportunities not only for biomedical research, but also for developing novel therapies. Applications based on these genome editing tools to disrupt deleterious genes, correct genetic mutations, deliver functional transgenes more effectively or even modify the epigenetic landscape are being actively investigated for gene and cell therapy purposes. Encouraging results have been obtained in limited clinical trials in the past two years. While most of the applications are still in proof-of-principle or preclinical development stages, it is anticipated that the coming years will see increasing clinical success in novel therapies based on the modern genome editing technologies. It should be noted that critical issues still remain before the technologies can be translated into more reliable therapies. These key issues include off-target evaluation, establishing appropriate preclinical models and improving the currently low efficiency of homology-based precise gene replacement. In this review we discuss the preclinical and clinical studies aiming at translating the genome editing technologies as well as the issues that are important for more successful translation.

  12. The commercialization of genome-editing technologies.

    Science.gov (United States)

    Brinegar, Katelyn; K Yetisen, Ali; Choi, Sun; Vallillo, Emily; Ruiz-Esparza, Guillermo U; Prabhakar, Anand M; Khademhosseini, Ali; Yun, Seok-Hyun

    2017-11-01

    The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from basic research to translational medicine. In our analyses, we evaluated the patent landscape of gene-editing technologies and found that in comparison to earlier gene-editing techniques, CRISPR has gained significant traction and this has established dominance. Although most of the gene-editing technologies originated from the industry, CRISPR has been pioneered by academic research institutions. The spinout of CRISPR biotechnology companies from academic institutions demonstrates a shift in entrepreneurship strategies that were previously led by the industry. These academic institutions, and their subsequent companies, are competing to generate comprehensive intellectual property portfolios to rapidly commercialize CRISPR products. Our analysis shows that the emergence of CRISPR has resulted in a fivefold increase in genome-editing bioenterprise investment over the last year. This entrepreneurial movement has spurred a global biotechnology revolution in the realization of novel gene-editing technologies. This global shift in bioenterprise will continue to grow as the demand for personalized medicine, genetically modified crops and environmentally sustainable biofuels increases. However, the monopolization of intellectual property, negative public perception of genetic engineering and ambiguous regulatory policies may limit the growth of these market segments.

  13. Ultra-Low Voltage Sixth-Order Low Pass Filter for Sensing the T-Wave Signal in ECGs

    Directory of Open Access Journals (Sweden)

    Panagiotis Bertsias

    2014-11-01

    Full Text Available An ultra-low voltage sixth-order low pass filter topology, suitable for sensing the T-wave signal in an electrocardiogram (ECG, is presented in this paper. This is realized using a cascade connection of second-order building blocks constructed from a sinh-domain two-integrator loop. The performance of the filter has been evaluated using the Cadence Analog Design Environment and the design kit provided by the Austria Mikro Systeme (AMS 0.35-µm CMOS process. The power consumption of filters was 7.21 nW, while a total harmonic distortion (THD level of 4% was observed for an input signal of 220 pA. The RMS value of the input referred noise was 0.43 pA, and the simulated value of the dynamic range (DR was 51.1 dB. A comparison with already published counterparts shows that the proposed topology offers the benefits of 0.5-V supply voltage operation and significantly improved power efficiency.

  14. Construction fraud

    NARCIS (Netherlands)

    Graafland, J.J.; Liedekerke, L.; Dubbink, W.; van Liedekerke, L.; van Luijk, H.

    2011-01-01

    Due to the actions of a whistleblower The Netherlands was confronted with a massive case of construction fraud involving almost the entire construction sector. Price fixing, prior consulting, duplicate accounts, fictitious invoices and active corruption of civil servants were rampant practices. This

  15. Superstring construction

    CERN Document Server

    1989-01-01

    The book includes a selection of papers on the construction of superstring theories, mainly written during the years 1984-1987. It covers ten-dimensional supersymmetric and non-supersymmetric strings, four-dimensional heterotic strings and four-dimensional type-II strings. An introduction to more recent developments in conformal field theory in relation to string construction is provided.

  16. Usability Constructs

    DEFF Research Database (Denmark)

    Hertzum, Morten; Clemmesen, Torkil; Hornbæk, Kasper Anders Søren

    2007-01-01

    frustrating systems are experienced similarly to easy-to-use systems. Looking at the most characteristic construct for each participant we find that Chinese participants use constructs related to security, task types, training, and system issues, whereas Danish and to some extent Indian participants make more...

  17. A Quantitative Study on the Correlation between Grade Span Configuration of Sixth Grade Students in Private Florida Schools and Academic Achievement on Standardized Achievement Scores

    Science.gov (United States)

    Rantin, Deborah

    2017-01-01

    The applied dissertation was designed to investigate the three models of grade span configurations of sixth grade and the effects grade span configuration has on results of the standardized achievement scores of sixth grade students in private, Florida schools. Studies that have been conducted on sixth grade students and grade span configuration…

  18. Book Review: New Perspectives on Technical Editing

    Science.gov (United States)

    Murphy, A. J. (Ed.); Sterken, Christiaan

    2012-08-01

    New Perspectives on Technical Editing by Avon J. Murphy (ed.) ISBN : 978-0895033949 (2010) Baywood Publishing Company Inc, Hardcover, 210 pages, 35.5 GBP This book presents a collection of 10 chapters dealing with diverse aspects of technical editing (ie, editorial planning, and analysis and structural changes made to other people's technological documents): research in technical editing, trends and teaching of technical editing, copyediting, and technical journal editing. The role and function of the modern journal and book editor is also dealt with in detail. Each chapter is written by an expert in the field: senior editors, university professors in technical communication, technical writers and linguists. The ever-evolving role of the editor is clearly elucidated in several historical reviews, and in the descriptions of the expectations for the future. A very striking aspect of this book is its extensive collection of bibliographic resources: every chapter lists dozens of very useful references, and the closing chapter, and annotated bibliography, contain many not so well known references, and are most useful. All in all, the book is a treasure trove listing more than 400 references, in addition to numerous webpage URLs embedded in the texts. The book is designed to help the reader to understand current practices and norms in technical editing, and to help to take action in editing as well as in teaching and educating would-be editors. The audience for this book thus includes editors and teachers, but also writers, researchers and students. A deep reading of this book will result in a better understanding of the difference between full technical editing and its much narrower component so well known as copyediting, and will convince any prospective editor that editing should not be undertaken if the people involved do not master the art of precision and accuracy in technical (as well as in human) communication, do not possess the technical know how and computer

  19. Prof Anyanwu 2009 dec edition...

    African Journals Online (AJOL)

    User

    the years, sought to find ways to stabilize the penis, reduce bleeding and enhance outcome of penile surgery.(2,3,4) In my practice, I have devised a self retaining ring retractor for urethroplasty in male children. This devise (Fig 1), constructed from a bucket handle is used to fix the penis by way of a stay suture at the glans ...

  20. Feedback on composition: a case study of a remedial sixth-grader Feedback on composition: a case study of a remedial sixth-grader

    Directory of Open Access Journals (Sweden)

    Marilda C. Cavalcanti

    2008-04-01

    Full Text Available This paper reports on a case study conducted in Brazil, aimed at investigating the relationship between what a Portuguese native-language teacher provided as feedback on compositions in a remedial sixth-grade class and what the students thought about and did with that feedback. The study called for the teacher to fill out a questionnaire and to provide verbal report protocol data while making comments on the composition of a selected student. The student also provided a verbal report protocol concerning his reactions to the feedback, and all the students in the class filled out a questionnaire about their handling of the feedback. This paper reports on a case study conducted in Brazil, aimed at investigating the relationship between what a Portuguese native-language teacher provided as feedback on compositions in a remedial sixth-grade class and what the students thought about and did with that feedback. The study called for the teacher to fill out a questionnaire and to provide verbal report protocol data while making comments on the composition of a selected student. The student also provided a verbal report protocol concerning his reactions to the feedback, and all the students in the class filled out a questionnaire about their handling of the feedback.

  1. Residential Wiring. Fourth Edition. Teacher Edition [and] Student Guide [and] Student Workbook.

    Science.gov (United States)

    Taylor, Mark

    Residential Wiring, the second publication in a series of three wiring publications, prepares students for entry-level employment in the residential wiring trade. Instructional materials include a teacher edition, student guide, and student workbook. The teacher edition begins with introductory pages, including a training and competency profile,…

  2. The sixth Euratom framework programme 2003-2006: a driving force for the construction of the Nuclear European Research Area

    International Nuclear Information System (INIS)

    Fernandez-Ruiz, P.; Forsstroem, H.; Goethem, G. van

    2005-01-01

    At the Lisbon 2000 summit, a strategic goal was proposed for the European Union: 'to become the most competitive knowledge-based economy with more and better employment and social cohesion by 2010'. Overall, in particular in the community of nuclear fission research, this EC initiative was well accepted by the main stakeholders. In Europe, the main stakeholders (i.e. suppliers and/or demanders) of nuclear research are actually: the research organisations (with mixed public/private funding), the manufacturing industry (or vendors), the utilities (or engineering companies), the regulatory bodies (or technical safety organisations) and the academia (or universities). In response to the Lisbon 2000 objectives, Commissioner P. BUSQUIN launched the concept of European Research Area (ERA) which sets also the frame for the FP-6. In this invited lecture, research and training in nuclear fission are looked at from a nuclear ERA perspective with emphasis on the three success factors of any European integration policy, namely: needs, vision and instruments, that ought to be strongly shared amongst the stakeholders in the EU-25. The following questions are addressed. What is driving the current EU trend towards more research, more education and more training in general? Regarding nuclear fission, in particular, who are the end-users of Euratom 'research and training' and what are their expectations (needs) from EU programmes? Do all stakeholders share the same vision about European research and training in nuclear fission? What are the instruments proposed by the Commission to the end-users to conduct joint research programmes? The above questions are all linked to nuclear knowledge management. It is shown that, in Community research, production of knowledge remains the most important objective, be it to generate products or services. However, dissemination/transfer (e.g. education and training) and exploitation (e.g. innovation) of knowledge become equally important as production, if one wants all energy options to remain open for the future generations. The answers to these questions and the examples given are taken primarily from reactor safety research (i.e. the area covered by FISA-2003) but are thought to be easily extrapolable to the other areas of nuclear fission research (i.e. radwaste management, innovative reactor concepts and safeguards, radiation protection, medical applications). In conclusion, amongst the stakeholders there seems to be a wide consensus about needs and instruments but a real common vision about a EU nuclear research strategy is still lacking. As a result, it is felt that European research in nuclear fission is still too much fragmented across Europe. It has not yet reached the 'critical mass' necessary to levy the governmental and industrial resources needed to face all challenges posed by an ageing nuclear power park and its renewal by the year 2015 (estimated end of lifetime)

  3. Bilateral superior rectus transposition and medial rectus recession for bilateral sixth nerve palsy.

    Science.gov (United States)

    Dai, Shuan; Bhambhwani, Vishaal; Raoof, Naz

    2018-03-01

    To present the results of bilateral superior rectus transposition with medial rectus recession in a case of chronic bilateral sixth nerve palsy. Bilateral superior rectus transposition with medial rectus recession resulted in full correction of esotropia with resolution of horizontal diplopia, improvement in abduction, and regain of stereoacuity in our case. There was minimal limitation of adduction, with no abnormal vertical or torsional changes. Bilateral superior rectus transposition with medial rectus recession appears to be a useful procedure for surgical treatment of bilateral sixth nerve palsy with minimal side effects. Given its potential for reduced risk of anterior segment ischemia (ASI), it may have especially good value in the select group of patients at risk for ASI. Studies with larger sample size and longer follow up are needed to further evaluate this procedure and elucidate the variables in surgical technique for superior rectus transposition.

  4. Sixth nerve palsy as the presenting symptom of metastatic colon carcinoma.

    Science.gov (United States)

    Kinori, Michael; Ben Bassat, Iris; Huna-Baron, Ruth

    2011-02-01

    Isolated cranial mononeuropathies in patients over 50 years of age most commonly result from microvascular ischemic demyelination. A 51-year-old female without vasculopathic risk factors presented with isolated sixth nerve palsy. Magnetic resonance imaging (MRI) of the brain and orbits revealed a cavernous sinus lesion that was diagnosed as a meningioma. Laboratory tests showed abnormal liver function, and an abdominal computerized tomogram demonstrated an obstructive colonic mass with liver metastasis. The pathology tests of specimens taken during a laparotomy diagnosed colon adenocarcinoma. The MRI interpretation was changed to cavernous sinus metastasis from a primary adenocarcinoma of the colon. This case had common cranial nerve symptoms but with a very rare etiology, emphasizing the importance of a high index of suspicion of remote origins in patients with isolated sixth nerve palsy and no atherosclerotic risk factors.

  5. A digital input class-D audio amplifier with sixth-order PWM

    Science.gov (United States)

    Shumeng, Luo; Dongmei, Li

    2013-11-01

    A digital input class-D audio amplifier with a sixth-order pulse-width modulation (PWM) modulator is presented. This modulator moves the PWM generator into the closed sigma—delta modulator loop. The noise and distortions generated at the PWM generator module are suppressed by the high gain of the forward loop of the sigma—delta modulator. Therefore, at the output of the modulator, a very clean PWM signal is acquired for driving the power stage of the class-D amplifier. A sixth-order modulator is designed to balance the performance and the system clock speed. Fabricated in standard 0.18 μm CMOS technology, this class-D amplifier achieves 110 dB dynamic range, 100 dB signal-to-noise rate, and 0.0056% total harmonic distortion plus noise.

  6. BOOK REVIEW: Quantum Gravity: third edition Quantum Gravity: third edition

    Science.gov (United States)

    Rovelli, Carlo

    2012-09-01

    The request by Classical and Quantum Gravity to review the third edition of Claus Kiefer's 'Quantum Gravity' puts me in a slightly awkward position. This is a remarkably good book, which every person working in quantum gravity should have on the shelf. But in my opinion quantum gravity has undergone some dramatic advances in the last few years, of which the book makes no mention. Perhaps the omission only attests to the current vitality of the field, where progress is happening fast, but it is strange for me to review a thoughtful, knowledgeable and comprehensive book on my own field of research, which ignores what I myself consider the most interesting results to date. Kiefer's book is unique as a broad introduction and a reliable overview of quantum gravity. There are numerous books in the field which (often notwithstanding titles) focus on a single approach. There are also countless conference proceedings and article collections aiming to be encyclopaedic, but offering disorganized patchworks. Kiefer's book is a careful and thoughtful presentation of all aspects of the immense problem of quantum gravity. Kiefer is very learned, and brings together three rare qualities: he is pedagogical, he is capable of simplifying matter to the bones and capturing the essential, and he offers a serious and balanced evaluation of views and ideas. In a fractured field based on a major problem that does not yet have a solution, these qualities are precious. I recommend Kiefer's book to my students entering the field: to work in quantum gravity one needs a vast amount of technical knowledge as well as a grasp of different ideas, and Kiefer's book offers this with remarkable clarity. This novel third edition simplifies and improves the presentation of several topics, but also adds very valuable new material on quantum gravity phenomenology, loop quantum cosmology, asymptotic safety, Horava-Lifshitz gravity, analogue gravity, the holographic principle, and more. This is a testament

  7. Interactive Editing of GigaSample Terrain Fields

    KAUST Repository

    Treib, Marc

    2012-05-01

    Previous terrain rendering approaches have addressed the aspect of data compression and fast decoding for rendering, but applications where the terrain is repeatedly modified and needs to be buffered on disk have not been considered so far. Such applications require both decoding and encoding to be faster than disk transfer. We present a novel approach for editing gigasample terrain fields at interactive rates and high quality. To achieve high decoding and encoding throughput, we employ a compression scheme for height and pixel maps based on a sparse wavelet representation. On recent GPUs it can encode and decode up to 270 and 730 MPix/s of color data, respectively, at compression rates and quality superior to JPEG, and it achieves more than twice these rates for lossless height field compression. The construction and rendering of a height field triangulation is avoided by using GPU ray-casting directly on the regular grid underlying the compression scheme. We show the efficiency of our method for interactive editing and continuous level-of-detail rendering of terrain fields comprised of several hundreds of gigasamples. © 2012 The Author(s).

  8. Cryptococcal Meningitis Presenting with Isolated Sixth Cranial Nerve Palsy in a Patient with Systemic Lupus Erythematosus

    Science.gov (United States)

    Kwok, Seung-Ki; Seo, Soo-Hong; Ju, Ji Hyeon; Yoon, Chong-Hyeon; Park, Soo Chul; Kim, Bum Soo; Kim, Ho-Youn

    2008-01-01

    Cryptococcal meningitis is a rare complication of systemic lupus erythematosus (SLE). The nonspecific neurologic findings associated with this infection delays accurate diagnosis because initial neuropsychiatric manifestations of SLE are in instances indistinguishable from that of crytococcal meningitis. We report a case of cryptococcal meningitis presenting with unilateral sixth cranial nerve palsy in a male patient with SLE, which was successfully treated with antifungal agents. PMID:18303219

  9. Proceedings of the sixth annual conference of the International Nuclear Target Development Society

    Energy Technology Data Exchange (ETDEWEB)

    Steers, G. (comp.)

    1978-08-01

    The Sixth Annual Conference of the International Nuclear Target Development Society was held at the Lawrence Berkeley Laboratory, University of California, Berkeley, California, on October 19--21, 1977. The discussion covered nuclear target preparation by evaporation, reduction of oxides, electrodeposition, reactive sputtering, rolling, gas jets, and related techniques. Abstracts were prepared for eighteen of the papers presented at the conference and are included in the data base. (GHT)

  10. A mixed finite element method for a sixth order elliptic problem

    OpenAIRE

    Droniou, Jérôme; Ilyas, Muhammad; Lamichhane, Bishnu; Wheeler, Glen E.

    2017-01-01

    We consider a saddle point formulation for a sixth order partial differential equation and its finite element approximation, for two sets of boundary conditions. We follow the Ciarlet-Raviart formulation for the biharmonic problem to formulate our saddle point problem and the finite element method. The new formulation allows us to use the $H^1$-conforming Lagrange finite element spaces to approximate the solution. We prove a priori error estimates for our approach. Numerical results are prese...

  11. Comparing maternal breastfeeding self-efficacy during first week and sixth week postpartum

    OpenAIRE

    Pakseresht, Sedighe; Pourshaban, Farzane; khalesi, Zahra Bostani

    2017-01-01

    Introduction The ideal nourishment for the first 12 months of a child?s life comes from breastfeeding its mother?s milk, and maternal self-efficacy is one factor which affects breastfeeding duration. Therefore, the present study aimed to compare the maternal breastfeeding self-efficacy during the first week and sixth-week postpartum. Methods This descriptive, analytical study was conducted on 767 women referring to the Family Health Research Center of Rasht in 2014. Mothers were selected thro...

  12. Proceedings of the sixth international conference on fluidized bed combustion. Volume III. Technical sessions

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-08-01

    The Sixth International Conference on Fluidized Bed Combustion was held April 9-11, 1980, at the Atlanta Hilton, Atlanta, Georgia. It was sponsored by the US Department of Energy, the Electric Power Research Institute, the US Environmental Protection Agency, and the Tennessee Valley Authority. Forty-five papers from Vol. III of the proceedings have been entered individually into EDB and ERA. Two papers had been entered previously from other sources. (LTN)

  13. US-Pakistan Strategic Partnership: A Track II Dialogue, Sixth Iteration

    Science.gov (United States)

    2012-01-01

    compulsion even if it were not the preferred policy course for Pakistan. As one Pakistani participant stated, “Pakistan...would therefore need to play its cards very carefully in managing its complex international relations; especially when its relations with its...any previous period. 37 U.S. Pakistan Strategic Dialogue (track II), Sixth Iteration Cover design credited to Mr. Alfred Woodson and Mr. Nick Masellis, CCC Research Associates

  14. Proceedings of the Sixth International Conference on Fluidized Bed Combustion. Volume 1. Plenary sessions

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-08-01

    The Sixth International Conference on Fluidized Bed Combustion was held at the Atlanta Hilton, Atlanta, Georgia, April 9-11, 1980. The papers in this volume involved presentation of the research and development programs of the US (US DOE, TVA, EPRI and US EPA), United Kingdom, Federal Republic of Germany and the People's Republic of China. Eight papers from Vol. 1 (Plenary Sessions) of the proceedings have been entered individually into EDB and ERA. (LTN)

  15. Propagation of perturbations for a sixth-order thin film equation

    Directory of Open Access Journals (Sweden)

    Zhenbang Li

    2012-07-01

    Full Text Available We consider an initial-boundary problem for a sixth-order thin film equation, which arises in the industrial application of the isolation oxidation of silicon. Relying on some necessary uniform estimates of the approximate solutions, we prove the existence of radial symmetric solutions to this problem in the two-dimensional space. The nonnegativity and the finite speed of propagation of perturbations of solutions are also discussed.

  16. Some Properties of Solutions for the Sixth-Order Cahn-Hilliard-Type Equation

    Directory of Open Access Journals (Sweden)

    Zhao Wang

    2012-01-01

    Full Text Available We study the initial boundary value problem for a sixth-order Cahn-Hilliard-type equation which describes the separation properties of oil-water mixtures, when a substance enforcing the mixing of the phases is added. We show that the solutions might not be classical globally. In other words, in some cases, the classical solutions exist globally, while in some other cases, such solutions blow up at a finite time. We also discuss the existence of global attractor.

  17. Accelerated modern human?induced species losses: Entering the sixth mass extinction

    OpenAIRE

    Ceballos, Gerardo; Ehrlich, Paul R.; Barnosky, Anthony D.; Garc?a, Andr?s; Pringle, Robert M.; Palmer, Todd M.

    2015-01-01

    The oft-repeated claim that Earth?s biota is entering a sixth ?mass extinction? depends on clearly demonstrating that current extinction rates are far above the ?background? rates prevailing between the five previous mass extinctions. Earlier estimates of extinction rates have been criticized for using assumptions that might overestimate the severity of the extinction crisis. We assess, using extremely conservative assumptions, whether human activities are causing a mass extinction. First, we...

  18. Bilateral superior rectus transposition and medial rectus recession for bilateral sixth nerve palsy

    Directory of Open Access Journals (Sweden)

    Shuan Dai

    2018-03-01

    Conclusion and importance: Bilateral superior rectus transposition with medial rectus recession appears to be a useful procedure for surgical treatment of bilateral sixth nerve palsy with minimal side effects. Given its potential for reduced risk of anterior segment ischemia (ASI, it may have especially good value in the select group of patients at risk for ASI. Studies with larger sample size and longer follow up are needed to further evaluate this procedure and elucidate the variables in surgical technique for superior rectus transposition.

  19. An unusual case of isolated sixth cranial nerve palsy in leprosy.

    Science.gov (United States)

    Vaishampayan, Sanjeev; Borde, Priyanka

    2012-08-15

    Cranial nerve involvement is not common in leprosy. The fifth and seventh cranial nerves are the most commonly affected in leprosy. Herein we present a patient with Hansen disease (BL) with type I reaction who developed isolated involvement of the sixth cranial nerve leading to lateral rectus muscle palsy. He responded to timely anti-reactional therapy and it produced a good response. Careful observation of patients with lepra reaction is needed to avoid damage to important organs.

  20. Long-term outcomes after surgical management of chronic sixth nerve palsy.

    Science.gov (United States)

    Holmes, Jonathan M; Leske, David A

    2002-10-01

    In a multicenter prospective data collection study of chronic sixth cranial nerve palsy, we previously reported that the initial successful outcome rate was 39% after a single surgical intervention and 25% after surgery combined with botulinum toxin (Botox), using strict success criteria. We now report the longer term outcome of these patients. A previously described cohort of 31 patients in 18 centers who underwent strabismus surgery for a sixth nerve palsy of greater that 6 months duration was studied prospectively. Twenty-three had strabismus surgery alone and 8 surgery with Botox. Fourteen (45%) were complete palsies and 17 (55%) were incomplete. Seven (23%) were bilateral and 24 (77%) were unilateral. Outcome was classified at time of last follow-up, which was 5 weeks to 24 months postoperatively. Success was defined as no diplopia in primary position at distance fixation. Partial success was defined as no more than 10 PD esotropia despite diplopia. Overall, 16 (52%) of the patients were classified as successes, 7 (23%) as partial successes, and 8 (25%) as failures. Three (43%) of the partial successes were using prism. Eight (35%) of the patients classified as successes or partial successes required 2 surgical procedures. Of all patients (10, 32%) who had a second surgery, only 2 (20%) remained failures. Despite our reported poor initial surgical success rate in chronic sixth nerve palsy, additional strabismus surgery, longer follow-up, and the use of prism or face turn for small residual deviations yields an overall surgical success rate of 75%. More than 1 surgical procedure and prism are often necessary in the management of chronic sixth nerve palsy.

  1. Abstracts of the sixth international conference on modern problems of nuclear physics

    International Nuclear Information System (INIS)

    Yuldashev, B.; Fazylov, M.; Ibragimova, E.; Salikhbaev, U.

    2006-09-01

    The Sixth International Conference on modern problems of nuclear physics was held on 19-22 September, 2006 in Tashkent, Uzbekistan. The specialists discussed various aspects of modern problems of both fundamental and applied nuclear physics. About 275 talks were presented in the meetingof on the following subjects: particle physics, relativistic nuclear physics and physics of atomic nuclei; radiation physics of condenced matter; nuclear applications in industry, medicine, biology and agriculture; nuclear and radiation safety, non prolifaration issues. (K.M.)

  2. Sixth research coordination meeting on the measurement and evaluation of transactinium isotope nuclear data

    International Nuclear Information System (INIS)

    Lorenz, A.

    1983-11-01

    Proceedings of the sixth meeting of the participants in the IAEA Coordinated Research Programme to measure and evaluate the required nuclear decay data of heavy element radionuclides, convened by the IAEA Nuclear Data Section on 21-24 June 1983 at Idaho Falls, USA. The meeting participants reviewed the data requirements, updated and extended the recommended list of half-lives, and continued to review the status of alpha and gamma radiation spectra emitted in the decay of transactinium isotopes

  3. Simultaneous involvement of third and sixth cranial nerve in a patient with Lyme disease

    Energy Technology Data Exchange (ETDEWEB)

    Lell, M.; Schmid, A.; Tomandl, B.F. [Division of Neuroradiology, Department of Neurosurgery, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen (Germany); Stemper, B.; Maihoefner, C.; Heckmann, J.G. [Department of Neurosurgery, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen (Germany)

    2003-02-01

    We report a 57-year-old woman with neuroborreliosis presenting with headache, shoulder muscle pain and double vision. MRI demonstrated enhancement of the right third and sixth cranial nerves. A 3D MP-RAGE sequence was used to perform multiplanar reformations to show this more graphically. The patient was free of symptoms 1 month after completion of therapy, when thickening and contrast enhancement of the nerves were less pronounced. (orig.)

  4. Genome Editing of Monogenic Neuromuscular Diseases

    Science.gov (United States)

    Long, Chengzu; Amoasii, Leonela; Bassel-Duby, Rhonda; Olson, Eric N.

    2017-01-01

    IMPORTANCE Muscle weakness, the most common symptom of neuromuscular disease, may result from muscle dysfunction or may be caused indirectly by neuronal and neuromuscular junction abnormalities. To date, more than 780 monogenic neuromuscular diseases, linked to 417 different genes, have been identified in humans. Genome-editing methods, especially the CRISPR (clustered regularly interspaced short palindromic repeats)–Cas9 (CRISPR-associated protein 9) system, hold clinical potential for curing many monogenic disorders, including neuromuscular diseases such as Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, and myotonic dystrophy type 1. OBJECTIVES To provide an overview of genome-editing approaches; to summarize published reports on the feasibility, efficacy, and safety of current genome-editing methods as they relate to the potential correction of monogenic neuromuscular diseases; and to highlight scientific and clinical opportunities and obstacles toward permanent correction of disease-causing mutations responsible for monogenic neuromuscular diseases by genome editing. EVIDENCE REVIEW PubMed and Google Scholar were searched for articles published from June 30, 1989, through June 9, 2016, using the following keywords: genome editing, CRISPR-Cas9, neuromuscular disease, Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, andmyotonic dystrophy type 1. The following sources were reviewed: 341 articles describing different approaches to edit mammalian genomes; 330 articles describing CRISPR-Cas9–mediated genome editing in cell culture lines (in vitro) and animal models (in vivo); 16 websites used to generate single-guide RNA; 4 websites for off-target effects; and 382 articles describing viral and nonviral delivery systems. Articles describing neuromuscular diseases, including Duchenne muscular dystrophy, spinal muscular atrophy, amyotrophic lateral sclerosis, and myotonic dystrophy type 1

  5. Designed nucleases for targeted genome editing.

    Science.gov (United States)

    Lee, Junwon; Chung, Jae-Hee; Kim, Ho Min; Kim, Dong-Wook; Kim, Hyongbum

    2016-02-01

    Targeted genome-editing technology using designed nucleases has been evolving rapidly, and its applications are widely expanding in research, medicine and biotechnology. Using this genome-modifying technology, researchers can precisely and efficiently insert, remove or change specific sequences in various cultured cells, micro-organisms, animals and plants. This genome editing is based on the generation of double-strand breaks (DSBs), repair of which modifies the genome through nonhomologous end-joining (NHEJ) or homology-directed repair (HDR). In addition, designed nickase-induced generation of single-strand breaks can also lead to precise genome editing through HDR, albeit at relatively lower efficiencies than that induced by nucleases. Three kinds of designed nucleases have been used for targeted DSB formation: zinc-finger nucleases, transcription activator-like effector nucleases, and RNA-guided engineered nucleases derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) system. A growing number of researchers are using genome-editing technologies, which have become more accessible and affordable since the discovery and adaptation of CRISPR-Cas9. Here, the repair mechanism and outcomes of DSBs are reviewed and the three types of designed nucleases are discussed with the hope that such understanding will facilitate applications to genome editing. © 2015 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

  6. Study of mosaic glasses from the Alpha Basilica (sixth century of Nikopolis in Epirus, Greece

    Directory of Open Access Journals (Sweden)

    Cesare Fiori

    2014-02-01

    Full Text Available After collecting the essential historical, archaeological, and artistic information relative to the ancient town of Nikopolis in Epirus and its Alpha (or Doumetios Basilica, built in the sixth century A.D., glass tesserae belonging to degraded and lost parts of the mosaic floors of the basilica were analysed, determining their chemical composition and the possible presence of crystalline phases. As in all glasses produced in the Mediterranean area in that epoch, they are soda-lime silicate glasses, in part with lead, obtained using natron as a flux. The typology of the glass corresponds to that of Roman glasses, of the first centuries A.D., and is the same as that employed for the basilicas of Ravenna in the fifth and sixth centuries; in particular, a comparison was made with the glass tesserae of the St Vitale Basilica. The technological base for producing coloured glasses is also practically the same as that of the mosaic glasses of Ravenna. In particular, antimony was used as an opacifying element and a fusion was carried out under reducing conditions to obtain red glass with microparticles of metallic copper. Thus, it can be supposed there was a common source of production of the mosaic glasses used in Nikopolis and Ravenna in the sixth century and that this source was in the Near Orient.

  7. Recurrent Isolated Sixth Nerve Palsy in Relapsing-Remitting Chronic Inflammatory Demyelinating Polyneuropathy.

    Science.gov (United States)

    Al-Bustani, Najwa; Weiss, Michael D

    2015-09-01

    Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated sensory and motor demyelinating polyneuropathy that typically presents as a relapsing-remitting or progressive disorder. Cranial neuropathies infrequently occur in association with other more typical symptoms of CIDP. We report a case of CIDP with recurrent isolated sixth nerve palsy. Her physical examination showed a right sixth nerve palsy and absent deep tendon reflexes as the only indicator of her disease. Magnetic resonance imaging revealed thickening without enhancement of the trigeminal and sixth cranial nerves. Nerve conduction study (NCS) revealed a sensory and motor demyelinating polyneuropathy with conduction block and temporal dispersion in multiple nerves consistent with CIDP. Cerebrospinal fluid demonstrated albuminic-cytologic dissociation. She had a remarkable response to intravenous immunoglobulin and remains asymptomatic without any additional immunomodulating therapy. Isolated cranial neuropathies can rarely occur as the sole manifestation of relapsing-remitting CIDP. The profound demyelination found on NCS in this case demonstrates that there can be a dramatic discordance between the clinical and electrodiagnostic findings in some patients with this disorder.

  8. The effects of collaborative video production on the attitudes and science knowledge of sixth graders

    Science.gov (United States)

    Gaston, Joseph Pickett

    This quantitative study examined the effects of collaborative video production (CVP) on the attitudes and conceptual understanding of sixth-grade science students at a public middle school in the Southeastern United States. This study followed the nonequivalent control group design, as described by Campbell and Stanley (1963). The study involved four classes of sixth-grade students. The two control classes were taught the science concept by the cooperating teacher through direct instruction, and the two experimental classes learned the science concept through the CVP project. Pre- and posttests were administered to all students, as well as two pre- and post-surveys measuring student attitudes towards science and technology. Analysis of covariance (ANCOVA) with the pretest scores as the covariate (Xc) was conducted with the posttest and post-survey data to determine if a significant difference existed in scores between the two groups. In each case, no significant difference was found. The results of this study suggest that CVP was as effective at conveying conceptual understanding to sixth-grade science students as direct instruction. Although not significant, the study also showed that mean scores of students' attitudes towards science and technology increased from pre-surveys to post-surveys for those who participated in the CVP activity. These findings suggest that the treatment contributed to an increase in participants' attitudes and towards technology and the academic subject. No such increase in mean post-survey scores existed for students receiving direct instruction.

  9. Worldwide construction

    International Nuclear Information System (INIS)

    Williamson, M.

    1994-01-01

    The paper lists major construction projects in worldwide processing and pipelining, showing capacities, contractors, estimated costs, and time of construction. The lists are divided into refineries, petrochemical plants, sulfur recovery units, gas processing plants, pipelines, and related fuel facilities. This last classification includes cogeneration plants, coal liquefaction and gasification plants, biomass power plants, geothermal power plants, integrated coal gasification combined-cycle power plants, and a coal briquetting plant

  10. 241-AP Tank Farm Construction Extent of Condition Review for Tank Integrity

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, Travis J.; Gunter, Jason R.; Reeploeg, Gretchen E.

    2014-04-04

    This report provides the results of an extent of condition construction history review for the 241-AP tank farm. The construction history of the 241-AP tank farm has been reviewed to identify issues similar to those experienced during tank AY-102 construction. Those issues and others impacting integrity are discussed based on information found in available construction records, using tank AY-102 as the comparison benchmark. In the 241-AP tank farm, the sixth double-shell tank farm constructed, tank bottom flatness, refractory material quality, post-weld stress relieving, and primary tank bottom weld rejection were improved.

  11. Construction history and construction management

    International Nuclear Information System (INIS)

    Agh, S.

    1999-01-01

    The process of pre-design and design preparation of the Mochovce NPP as well as the construction history of the plant is highlighted, including the financing aspect and problems arising from changes in the technological and other conditions of start-up of the reactor units. The results of international audits performed to improve the level of nuclear safety and implementation of the measures suggested are also described. The milestones of the whole construction process and start-up process, the control and quality system, and the methods of control and management of the complex construction project are outlined. (author)

  12. Introduction to nuclear science, second edition

    CERN Document Server

    Bryan, Jeff C.

    2013-01-01

    This book was written to provide students who have limited backgrounds in the physical sciences and math with an accessible textbook on nuclear science. Expanding on the foundation of the bestselling first edition, Introduction to Nuclear Science, Second Edition provides a clear and complete introduction to nuclear chemistry and physics, from basic concepts to nuclear power and medical applications. Incorporating suggestions from professors using this book for their courses, the author has created a new text that is approximately 60 percent larger and more comprehensive and flexible than the first.New to This Edition: Thorough review of nuclear forensics, radiology, gamma cameras, and decay through proton or neutron emission More detailed explanations of the necessary mathematics A chapter on dosimetry of radiation fields Expanded discussion of applications, introduced earlier in the text More in-depth coverage of nuclear reactors, including a new chapter examining more reactor types, their safety systems,...

  13. Ethical and regulatory aspects of genome editing.

    Science.gov (United States)

    Kohn, Donald B; Porteus, Matthew H; Scharenberg, Andrew M

    2016-05-26

    Gene editing is a rapidly developing area of biotechnology in which the nucleotide sequence of the genome of living cells is precisely changed. The use of genome-editing technologies to modify various types of blood cells, including hematopoietic stem cells, has emerged as an important field of therapeutic development for hematopoietic disease. Although these technologies offer the potential for generation of transformative therapies for patients suffering from myriad disorders of hematopoiesis, their application for therapeutic modification of primary human cells is still in its infancy. Consequently, development of ethical and regulatory frameworks that ensure their safe and effective use is an increasingly important consideration. Here, we review a number of issues that have the potential to impact the clinical implementation of genome-editing technologies, and suggest paths forward for resolving them such that new therapies can be safely and rapidly translated to the clinic. © 2016 by The American Society of Hematology.

  14. Generation of Gene-Edited Chrysanthemum morifolium Using Multicopy Transgenes as Targets and Markers.

    Science.gov (United States)

    Kishi-Kaboshi, Mitsuko; Aida, Ryutaro; Sasaki, Katsutomo

    2017-02-01

    The most widely used gene editing technology-the CRISPR/Cas9 system-employs a bacterial monomeric DNA endonuclease known as clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) and single-guide RNA (sgRNA) that directs Cas9 to a complementary target DNA. However, introducing mutations into higher polyploid plant species, especially for species without genome information, has been difficult. Chrysanthemum morifolium (chrysanthemum) is one of the most important ornamental plants, but it is a hexaploid with a large genome; moreover, it lacks whole-genome information. These characteristics hinder genome editing in chrysanthemum. In the present study, we attempted to perform gene editing using the CRISPR/Cas9 system to introduce mutations into chrysanthemum. We constructed transgenic chrysanthemum plants expressing the yellowish-green fluorescent protein gene from Chiridius poppei (CpYGFP) and targeted CpYGFP for gene editing. We compared the activity of a Cauliflower mosaic virus (CaMV) 35S promoter and parsley ubiquitin promoter in chrysanthemum calli and chose the parsley ubiquitin promoter to drive Cas9. We selected two sgRNAs to target different positions in the CpYGFP gene and obtained transgenic calli containing mutated CpYGFP genes (CRISPR-CpYGFP-chrysanthemum). A DNA sequencing analysis and fluorescence observations indicated that cells containing the mutated CpYGFP gene grew independently of cells containing the original CpYGFP gene in one callus. We finally obtained the CRISPR-CpYGFP-chrysanthemum shoot containing a mutation in the CpYGFP sequence. This is the first report of gene editing using the CRISPR/Cas9 system in chrysanthemum and sheds light on chrysanthemum genome editing. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  15. In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.

    Science.gov (United States)

    El Refaey, Mona; Xu, Li; Gao, Yandi; Canan, Benjamin D; Adesanya, T M Ayodele; Warner, Sarah C; Akagi, Keiko; Symer, David E; Mohler, Peter J; Ma, Jianjie; Janssen, Paul M L; Han, Renzhi

    2017-09-29

    Duchenne muscular dystrophy is a severe inherited form of muscular dystrophy caused by mutations in the reading frame of the dystrophin gene disrupting its protein expression. Dystrophic cardiomyopathy is a leading cause of death in Duchenne muscular dystrophy patients, and currently no effective treatment exists to halt its progression. Recent advancement in genome editing technologies offers a promising therapeutic approach in restoring dystrophin protein expression. However, the impact of this approach on Duchenne muscular dystrophy cardiac function has yet to be evaluated. Therefore, we assessed the therapeutic efficacy of CRISPR (clustered regularly interspaced short palindromic repeats)-mediated genome editing on dystrophin expression and cardiac function in mdx/Utr +/- mice after a single systemic delivery of recombinant adeno-associated virus. To examine the efficiency and physiological impact of CRISPR-mediated genome editing on cardiac dystrophin expression and function in dystrophic mice. Here, we packaged SaCas9 (clustered regularly interspaced short palindromic repeat-associated 9 from Staphylococcus aureus ) and guide RNA constructs into an adeno-associated virus vector and systemically delivered them to mdx/Utr +/- neonates. We showed that CRIPSR-mediated genome editing efficiently excised the mutant exon 23 in dystrophic mice, and immunofluorescence data supported the restoration of dystrophin protein expression in dystrophic cardiac muscles to a level approaching 40%. Moreover, there was a noted restoration in the architecture of cardiac muscle fibers and a reduction in the extent of fibrosis in dystrophin-deficient hearts. The contractility of cardiac papillary muscles was also restored in CRISPR-edited cardiac muscles compared with untreated controls. Furthermore, our targeted deep sequencing results confirmed that our adeno-associated virus-CRISPR/Cas9 strategy was very efficient in deleting the ≈23 kb of intervening genomic sequences. This

  16. A Comprehensive Toolbox for Genome Editing in Cultured Drosophila melanogaster Cells

    Directory of Open Access Journals (Sweden)

    Stefan Kunzelmann

    2016-06-01

    Full Text Available Custom genome editing has become an essential element of molecular biology. In particular, the generation of fusion constructs with epitope tags or fluorescent proteins at the genomic locus facilitates the analysis of protein expression, localization, and interaction partners at physiologic levels. Following up on our initial publication, we now describe a considerably simplified, more efficient, and readily scalable experimental workflow for PCR-based genome editing in cultured Drosophila melanogaster cells. Our analysis at the act5C locus suggests that PCR-based homology arms of 60 bp are sufficient to reach targeting efficiencies of up to 80% after selection; extension to 80 bp (PCR or 500 bp (targeting vector did not further improve the yield. We have expanded our targeting system to N-terminal epitope tags; this also allows the generation of cell populations with heterologous expression control of the tagged locus via the copper-inducible mtnDE promoter. We present detailed, quantitative data on editing efficiencies for several genomic loci that may serve as positive controls or benchmarks in other laboratories. While our first PCR-based editing approach offered only blasticidin-resistance for selection, we now introduce puromycin-resistance as a second, independent selection marker; it is thus possible to edit two loci (e.g., for coimmunoprecipitation without marker removal. Finally, we describe a modified FLP recombinase expression plasmid that improves the efficiency of marker cassette FLP-out. In summary, our technique and reagents enable a flexible, robust, and cloning-free genome editing approach that can be parallelized for scale-up.

  17. Efficient genome-editing of wild strawberry genes, vector development, and validation.

    Science.gov (United States)

    Zhou, Junhui; Wang, Guoming; Liu, Zhongchi

    2018-03-25

    The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system is an effective genome editing tool for plant and animal genomes. However, there are still few reports on the successful application of CRISPR-Cas9 to horticultural plants, especially with regard to germline transmission of targeted mutations. Here we report high efficiency genome editing in the wild strawberry Fragaria vesca and its successful application to mutate the auxin biosynthesis gene TAA1 and Auxin Response Factor 8 (ARF8). In our CRISPR system, the Arabidopsis U6 promoter AtU6-26 and the wild strawberry U6 promoter FveU6-2 were each used to drive the expression of sgRNA, and both promoters were shown to lead to high efficiency genome editing in strawberry. To test germline transmission of the edited mutations and new mutations induced in the next generation, the progeny of the primary (T0) transgenic plants carrying the CRISPR construct were analyzed. New mutations were detected in the progeny plants at a high efficiency, including large deletions between the two PAM sites. Further, T1 plants harboring arf8 homozygous knockout mutations grew considerably faster than wild type plants. The results indicate that our CRISPR vectors can be used to edit the wild strawberry genome at a high efficiency and that both sgRNA design and appropriate U6 promoters contribute to the success of genomic editing. Our results open up exciting opportunities for engineering strawberry and related horticultural crops to improve traits of economic importance. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  18. Targeted editing of goat genome with modular-assembly zinc finger nucleases based on activity prediction by computational molecular modeling.

    Science.gov (United States)

    Xiong, Kai; Li, Shanshan; Zhang, Hongxiao; Cui, Ye; Yu, Debing; Li, Yan; Sun, Wenxing; Fu, Yingying; Teng, Yun; Liu, Zhi; Zhou, Xiaolong; Xiao, Peng; Li, Juan; Liu, Honglin; Chen, Jie

    2013-07-01

    Zinc finger nuclease (ZFN) technology can mediate targeted genome modification to produce transgenic animals in a high-efficient and biological-safe way. Modular assembly is a rapid, convenient and open-source method for the synthesis of ZFNs. However, this biotechnology is hampered by multistep construction, low-efficiency editing and off-target cleavage. Here we synthesized and tested six pairs of three- or four-finger ZFNs to target one site in goat beta-lactoglobulin (BLG, a dominant allergen in goat milk) gene. Homology modeling was applied to build the structure model of ZFNs to predict their editing activities targeting at goat BLG gene. Goat fibroblast cells were transfected with plasmids that encoded ZFN pairs, and genomic DNA was isolated 72 h later for genome editing efficiency assay. The results of editing efficiency assay demonstrated that ZFNs with optimal interaction modes can edit goat BLG gene more efficiently, whereas ZFNs with unexpected interaction modes showed lower activities in editing BLG gene. We concluded that modular-assembly ZFNs can provide a rapid, public-available, and easy-to-practice platform for transgenic animal research and molecular modeling would help as a useful tool for ZFNs activity prediction.

  19. Confirmatory Factor Structure of the Kaufman Assessment Battery for Children-Second Edition with Preschool Children: Too Young for Differentiation?

    Science.gov (United States)

    Potvin, Deborah C. H.; Keith, Timothy Z.; Caemmerer, Jacqueline M.; Trundt, Katherine M.

    2015-01-01

    With an age range from 3 to 13 years, the Kaufman Assessment Battery for Children-Second Edition (KABC-II) offers an appealing option for the assessment of cognitive abilities for children. Although independent research has provided evidence of the construct validity of the KABC-II for school-age children, previous studies have rarely included an…

  20. WITHDRAWN: Kee, J, Hayes E. and McCuistion L (2009) Pharmacology: A Nursing Process Approach, Sixth Edition (and accompanying study guide), Saunders Elsevier, St. Louis.

    Science.gov (United States)

    Keogh, Brian

    2009-08-22

    The Publisher regrets that this article is an accidental duplication of a Book Review that has already been published, doi: 10.1016/j.nepr.2009.07.002. The duplicate article has therefore been withdrawn.

  1. Transportation Energy Data Book, Edition 19

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    1999-09-01

    The Transportation Energy Data Book: Edition 19 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (http://www-cta.ornl.gov/data/tedb.htm).

  2. The Ethics of Germline Gene Editing.

    Science.gov (United States)

    Gyngell, Christopher; Douglas, Thomas; Savulescu, Julian

    2017-08-01

    Germline Gene Editing (GGE) has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, GGE has been strongly resisted. In this article, we analyse the ethical arguments for and against pursuing GGE by allowing and funding its development. We argue there is a strong case for pursuing GGE for the prevention of disease. We then examine objections that have been raised against pursuing GGE and argue that these fail. We conclude that the moral case in favour of pursuing GGE is stronger than the case against. This suggests that pursuing GGE is morally permissible and indeed morally desirable.

  3. Genome editing in zebrafish: a practical overview.

    Science.gov (United States)

    Sertori, Robert; Trengove, Monique; Basheer, Faiza; Ward, Alister C; Liongue, Clifford

    2016-07-01

    Zebrafish is a powerful model for the study of vertebrate development, being amenable to a wide range of genetic and other manipulations to probe the molecular basis of development and its perturbation in disease. Over recent years, genome editing approaches have become increasingly used as an efficient and sophisticated approach to precisely engineer the zebrafish genome, which has further enhanced the utility of this organism. This review provides a practical overview of genome editing and its application in zebrafish research, including alternate strategies for introducing and screening for specific genetic changes. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  4. Genome Editing in Human Pluripotent Stem Cells.

    Science.gov (United States)

    Carlson-Stevermer, Jared; Saha, Krishanu

    2017-01-01

    Genome editing in human pluripotent stem cells (hPSCs) enables the generation of reporter lines and knockout cell lines. Zinc finger nucleases, transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9 technology have recently increased the efficiency of proper gene editing by creating double strand breaks (DSB) at defined sequences in the human genome. These systems typically use plasmids to transiently transcribe nucleases within the cell. Here, we describe the process for preparing hPSCs for transient expression of nucleases via electroporation and subsequent analysis to create genetically modified stem cell lines.

  5. Global Bathymetry: Machine Learning for Data Editing

    Science.gov (United States)

    Sandwell, D. T.; Tea, B.; Freund, Y.

    2017-12-01

    The accuracy of global bathymetry depends primarily on the coverage and accuracy of the sounding data and secondarily on the depth predicted from gravity. A main focus of our research is to add newly-available data to the global compilation. Most data sources have 1-12% of erroneous soundings caused by a wide array of blunders and measurement errors. Over the years we have hand-edited this data using undergraduate employees at UCSD (440 million soundings at 500 m resolution). We are developing a machine learning approach to refine the flagging of the older soundings and provide automated editing of newly-acquired soundings. The approach has three main steps: 1) Combine the sounding data with additional information that may inform the machine learning algorithm. The additional parameters include: depth predicted from gravity; distance to the nearest sounding from other cruises; seafloor age; spreading rate; sediment thickness; and vertical gravity gradient. 2) Use available edit decisions as training data sets for a boosted tree algorithm with a binary logistic objective function and L2 regularization. Initial results with poor quality single beam soundings show that the automated algorithm matches the hand-edited data 89% of the time. The results show that most of the information for detecting outliers comes from predicted depth with secondary contributions from distance to the nearest sounding and longitude. A similar analysis using very high quality multibeam data shows that the automated algorithm matches the hand-edited data 93% of the time. Again, most of the information for detecting outliers comes from predicted depth secondary contributions from distance to the nearest sounding and longitude. 3) The third step in the process is to use the machine learning parameters, derived from the training data, to edit 12 million newly acquired single beam sounding data provided by the National Geospatial-Intelligence Agency. The output of the learning algorithm will be

  6. Current and future editing reagent delivery systems for plant genome editing.

    Science.gov (United States)

    Ran, Yidong; Liang, Zhen; Gao, Caixia

    2017-05-01

    Many genome editing tools have been developed and new ones are anticipated; some have been extensively applied in plant genetics, biotechnology and breeding, especially the CRISPR/Cas9 system. These technologies have opened up a new era for crop improvement due to their precise editing of user-specified sequences related to agronomic traits. In this review, we will focus on an update of recent developments in the methodologies of editing reagent delivery, and consider the pros and cons of current delivery systems. Finally, we will reflect on possible future directions.

  7. Editing of the urease gene by CRISPR-Cas in the diatom Thalassiosira pseudonana

    Directory of Open Access Journals (Sweden)

    Amanda Hopes

    2016-11-01

    Full Text Available Abstract Background CRISPR-Cas is a recent and powerful addition to the molecular toolbox which allows programmable genome editing. It has been used to modify genes in a wide variety of organisms, but only two alga to date. Here we present a methodology to edit the genome of Thalassiosira pseudonana, a model centric diatom with both ecological significance and high biotechnological potential, using CRISPR-Cas. Results A single construct was assembled using Golden Gate cloning. Two sgRNAs were used to introduce a precise 37 nt deletion early in the coding region of the urease gene. A high percentage of bi-allelic mutations (≤61.5% were observed in clones with the CRISPR-Cas construct. Growth of bi-allelic mutants in urea led to a significant reduction in growth rate and cell size compared to growth in nitrate. Conclusions CRISPR-Cas can precisely and efficiently edit the genome of T. pseudonana. The use of Golden Gate cloning to assemble CRISPR-Cas constructs gives additional flexibility to the CRISPR-Cas method and facilitates modifications to target alternative genes or species.

  8. Construction safety

    CERN Document Server

    Li, Rita Yi Man

    2013-01-01

    A close-to-ideal blend of suburb and city, speedy construction of towers of Babylon, the sparkling proportion of glass and steel buildings’ facade at night showcase the wisdom of humans. They also witness the footsteps, sweats and tears of architects and engineers. Unfortunately, these signatures of human civilizations are swathed in towering figures of construction accidents. Fretting about these on sites, different countries adopt different measures on sites. This book firstly sketches the construction accidents on sites, followed by a review on safety measures in some of the developing countries such as Bermuda, Egypt, Kuwait and China; as well as developed countries, for example, the United States, France and Singapore. It also highlights the enormous compensation costs with the courts’ experiences in the United Kingdom and Hong Kong.

  9. Shielded Metal Arc Welding and Carbon Arc Cutting--Air. Teacher Edition [and] Student Edition [and] Student Workbook. Third Edition.

    Science.gov (United States)

    Harper, Eddie; Knapp, John

    This document contains the teacher and student texts and student workbook for a secondary-level course in shielded metal arc welding (SMAW) and carbon arc cutting that consists of units on the following topics: SMAW safety; SMAW equipment, applications, and techniques; hardfacing; and carbon arc cutting--air. The teacher edition includes the…

  10. Experimental Stochatics (2nd edition)

    International Nuclear Information System (INIS)

    Wiberg, P

    2004-01-01

    for teachers of computational stochastic methods, is the main contribution of this electronic monograph. However, both the book and software suffer from several severe problems. Firstly, I feel that the structure of the text is weak. Probably this is partly the result of the text from the CD-ROM being put into a book format, but the short paragraphs and poorly structured sentences destroy the reading experience. Secondly, although the software is functional, I believe that, like me, many users will be disappointed by the quality of the user interface and the visualizations. The opportunities to interact with the simulations are limited. Thirdly, the presentation is slightly old fashioned and lacking in pedagogical structure. For example, flow charts and Pascal programs are used to present algorithms. To conclude, I am surprised that this electronic monograph warranted a second edition in this form. Teachers may find the examples useful as a starting point, but students and researchers are advised to look elsewhere. (book review)

  11. Unravelling the Franklin Mystery, Second Edition with David C. Woodman

    DEFF Research Database (Denmark)

    Burke, Danita Catherine

    2017-01-01

    This is a forthcoming book review of David C. Woodman's second edition of his book "Unravelling the Franklin Mystery."......This is a forthcoming book review of David C. Woodman's second edition of his book "Unravelling the Franklin Mystery."...

  12. Direct Visual Editing of Node Attributes in Graphs

    Directory of Open Access Journals (Sweden)

    Christian Eichner

    2016-10-01

    Full Text Available There are many expressive visualization techniques for analyzing graphs. Yet, there is only little research on how existing visual representations can be employed to support data editing. An increasingly relevant task when working with graphs is the editing of node attributes. We propose an integrated visualize-and-edit approach to editing attribute values via direct interaction with the visual representation. The visualize part is based on node-link diagrams paired with attribute-dependent layouts. The edit part is as easy as moving nodes via drag-and-drop gestures. We present dedicated interaction techniques for editing quantitative as well as qualitative attribute data values. The benefit of our novel integrated approach is that one can directly edit the data while the visualization constantly provides feedback on the implications of the data modifications. Preliminary user feedback indicates that our integrated approach can be a useful complement to standard non-visual editing via external tools.

  13. Constructing an Archive Yearbook 2015/2016

    DEFF Research Database (Denmark)

    Carbone, Claudia; Wieczorek, Izabela; Skafte Andersen, Mathias

    2016-01-01

    Constructing an Archive—Yearbook 2015/2016 contains a collection of student works conducted during the Fall semester of 2015 and the Spring semester of 2016 at the Aarhus School of Architecture. The publication has been designed and edited by the students and teachers of the studio Constructing...... an Archive and is an attempt to record the journey undertaken during this year of studies. Its organisation corresponds to the experimental approach of the studio, intertwining pieces of collective and individual works, which can be read and experience as a heterogeneous assemblage, hopefully opening up new...

  14. Construction work

    CERN Multimedia

    2004-01-01

    Construction work on building 179 will start on the 16th February 2004 and continue until November 2004. The road between buildings 179 and 158 will temporarily become a one way street from Route Democrite towards building 7. The parking places between buildings 179 and 7 will become obsolete. The ISOLDE collaboration would like to apologize for any inconveniences.

  15. Scale Construction.

    Science.gov (United States)

    Dawis, Rene V.

    1987-01-01

    Discusses design, development, and evaluation of scales used in counseling psychology research. Describes methods of scale construction including the Thurstone, Q-sort, rank-order methods, Likert, semantic differential, Guttman, Rasch, and external criterion methods. Presents ways of evaluating newly developed scales. Discusses measurement versus…

  16. Human Resources Administration: A School-Based Perspective. Fourth Edition

    Science.gov (United States)

    Smith, Richard

    2009-01-01

    Enhanced and updated, this Fourth Edition of Richard E. Smith's highly successful text examines the growing role of the principal in planning, hiring, staff development, supervision, and other human resource functions. The Fourth Edition includes new sections on ethics, induction, and the role of the mentor teacher. This edition also introduces…

  17. Editing modifies the GABA(A) receptor subunit alpha3

    DEFF Research Database (Denmark)

    Ohlson, Johan; Pedersen, Jakob Skou; Haussler, David

    2007-01-01

    to find selectively edited sites and combined it with bioinformatic techniques that find stem-loop structures suitable for editing. We present here the first verified editing candidate detected by this screening procedure. We show that Gabra-3, which codes for the alpha3 subunit of the GABA(A) receptor...

  18. Editing Bosman's stories | MacKenzie | Current Writing: Text and ...

    African Journals Online (AJOL)

    This article looks back at the editing work that went into the fourteen-volume Anniversary Edition of Herman Charles Bosman (1998–2005) and pays particular attention to the editing of Bosman's stories. It examines some of the problems that were encountered in arriving at 'authoritative' versions of the stories and argues ...

  19. Soil Carbon Sequestration and the Greenhouse Effect (2nd Edition)

    Science.gov (United States)

    This volume is a second edition of the book “Soil Carbon Sequestration and The Greenhouse Effect”. The first edition was published in 2001 as SSSA Special Publ. #57. The present edition is an update of the concepts, processes, properties, practices and the supporting data. All chapters are new co...

  20. Let's Talk About Docs (NCSA Edition)

    OpenAIRE

    Sick, Jonathan

    2016-01-01

    User documentation is an essential part of delivering great software. This presentation frames how we should think about user documentation (as software developers and researchers). It covers the three types of documentation (tutorials, user guides and references), and how these formats work together. Finally, the presentation gives some advice on effective technical writing and editing.

  1. Positive Behavior Support Training Curriculum. Second Edition

    Science.gov (United States)

    Reid, Dennis H.; Parsons, Marsha B.

    2007-01-01

    The American Association on Intellectual and Developmental Disabilities' (AAIDD's) Positive Behavior Support Training Curriculum," Second Edition" ("PBSTC"), is a curriculum for training direct support personnel and their supervisors in the values and practices of Positive Behavior Support. The curriculum is designed for direct support persons and…

  2. Does Money Matter in Education? Second Edition

    Science.gov (United States)

    Baker, Bruce D.

    2016-01-01

    This second edition policy brief revisits the long and storied literature on whether money matters in providing a quality education. It includes research released since the original brief in 2012 and covers a handful of additional topics. Increasingly, political rhetoric adheres to the unfounded certainty that money does not make a difference in…

  3. The NMC Horizon Report: 2013 Museum Edition

    Science.gov (United States)

    Johnson, L.; Adams Becker, S.; Freeman, A.

    2013-01-01

    The "NMC Horizon Report: 2013 Museum Edition," is a co-production with the Marcus Institute for Digital Education in the Arts (MIDEA), and examines six emerging technologies for their potential impact on and use in education and interpretation within the museum environment: BYOD (Bring Your Own Device), crowdsourcing, electronic…

  4. The Art of Electronics - 2nd Edition

    Science.gov (United States)

    Horowitz, Paul; Hill, Winfield

    1989-09-01

    This is the thoroughly revised and updated second edition of the hugely successful The Art of Electronics. Widely accepted as the single authoritative text and reference on electronic circuit design, both analog and digital, the original edition sold over 125,000 copies worldwide and was translated into eight languages. The book revolutionized the teaching of electronics by emphasizing the methods actually used by citcuit designers - a combination of some basic laws, rules to thumb, and a large nonmathematical treatment that encourages circuit values and performance. The new Art of Electronics retains the feeling of informality and easy access that helped make the first edition so successful and popular. It is an ideal first textbook on electronics for scientists and engineers and an indispensable reference for anyone, professional or amateur, who works with electronic circuits. The best self-teaching book and reference book in electronics Simply indispensable, packed with essential information for all scientists and engineers who build electronic circuits Totally rewritten chapters on microcomputers and microprocessors The first edition of this book has sold over 100,000 copies in seven years, it has a market in virtually all research centres where electronics is important

  5. Handbook of paediatric radiography. Second edition

    International Nuclear Information System (INIS)

    Gyll, C.

    1985-01-01

    This book gives some ideas on how to achieve good radiographs of children. In this second edition most papers are expanded and brought up to date, the paper on the neonate completely rewritten, and a discussion of child development and child psychology added

  6. Ladybugs of South Dakota, 2nd edition

    Science.gov (United States)

    Images of the 80 species of Coccinellidae, commonly known as lady beetles, that occur in South Dakota are presented in taxonomic order. The second edition updates information, including the addition of a species new to South Dakota. Information on each species includes genus-species name, sub-fami...

  7. International guide to the circus. - 2015 edition

    NARCIS (Netherlands)

    Huey, R.; Albrecht, E.; Belbahri, N.; Brunsdale, M.; Christian, J.; Garcia, J.; Giarola, A.; Jando, D.; Lehmann, R.; Marier, F.; Nieminen, K.; Parkinson, G.; Pierce, R.D.; Revolledo Cárdenas, J.; Rodenhuis, W.; Serena, A.; Schlotfeldt, A.; Shaina, C.; Shrake, P.; Simon, M.; St. Leon, M.; Stone, C.; Cooper, J.; Tamaoki, V.; Winkler, G.

    2015-01-01

    An easy-to-read publication defining 100 key circus terms translated in nine languages. The 2015 edition has been re-created in a smaller "pocket" version, 44 pages in length and weighing 63 grams per book. Additional images have been added to illustrate terms and each book is sold complete with a

  8. Thermodynamics of Fluids Under Flow Second Edition

    CERN Document Server

    Jou, David; Criado-Sancho, Manuel

    2011-01-01

    This is the second edition of the book “Thermodynamics of Fluids under Flow,” which was published in 2000 and has now been corrected, expanded and updated. This is a companion book to our other title Extended irreversible thermodynamics (D. Jou, J. Casas-Vázquez and G. Lebon, Springer, 4th edition 2010), and of the textbook Understanding non-equilibrium thermodynamics (G. Lebon, D. Jou and J. Casas-Vázquez, Springer, 2008. The present book is more specialized than its counterpart, as it focuses its attention on the non-equilibrium thermodynamics of flowing fluids, incorporating non-trivial thermodynamic contributions of the flow, going beyond local equilibrium theories, i.e., including the effects of internal variables and of external forcing due to the flow. Whereas the book's first edition was much more focused on polymer solutions, with brief glimpses into ideal and real gases, the present edition covers a much wider variety of systems, such as: diluted and concentrated polymer solutions, polymer ble...

  9. Handbook: Emergency Legal Procedures. [Third Edition].

    Science.gov (United States)

    Apperson, Ron; Waxman, Everett

    This is the latest edition of a handbook designed to assist school administrators in preventing and dealing with school disruptions and certain related legal matters. Because the handbook was prepared specifically for use by administrators in the Los Angeles Unified School District, it is based on laws and regulations that may not apply elsewhere.…

  10. Efficient Communication Protocols for Deciding Edit Distance

    DEFF Research Database (Denmark)

    Jowhari, Hossein

    2012-01-01

    In this paper we present two communication protocols on computing edit distance. In our first result, we give a one-way protocol for the following Document Exchange problem. Namely given x ∈ Σn to Alice and y ∈ Σn to Bob and integer k to both, Alice sends a message to Bob so that he learns x...

  11. A Snapshot of Photo Editing Options

    Science.gov (United States)

    Bolkan, J.V.

    2004-01-01

    Plenty of digital imaging professionals claim that Adobe's Photoshop CS is the best photo editing application money can buy. This document reviews Adobe's Photoshop CS and its worthy competitors. In addition to Adobe, the following programs are reviewed in this document: (1) Adobe Photoshop Elements 2.0; (2) Arcsoft PhotoImpression; (3) Jasc Paint…

  12. Power Technologies Data Book 2003 Edition

    Energy Technology Data Exchange (ETDEWEB)

    Aabakken, J.

    2004-06-01

    The 2003 edition of this report, prepared by NREL's Energy Analysis Office, includes up-to-date information on power technologies, including complete technology profiles. The data book also contains charts on electricity restructuring, power technology forecasts and comparisons, electricity supply, electricity capability, electricity generation, electricity demand, prices, economic indicators, environmental indicators, conversion factors, and selected congressional questions and answers.

  13. A DESCRIPTIVE INDONESIAN GRAMMAR--PRELIMINARY EDITION.

    Science.gov (United States)

    DYEN, ISIDORE

    THIS PRELIMINARY EDITION COMPRISES A DESCRIPTIVE GRAMMAR OF INDONESIAN (BAHASA INDONESIA), THE OFFICIAL LANGUAGE OF THE REPUBLIC OF INDONESIA. THE THREE SECTIONS--PHONOLOGY, SYNTAX, AND MORPHOLOGY--PRESENT A COMPREHENSIVE LINGUISTIC ANALYSIS OF INDONESIAN, WITH OCCASIONAL CONTRASTIVE REFERENCE TO MALAY, JAVANESE, SUNDANESE, AND SUMATRAN. THIS…

  14. Grants for Children & Youth--2012 Digital Edition

    Science.gov (United States)

    Foundation Center, 2011

    2011-01-01

    This publication is only available as a downloadable file. See who's giving and getting grants in your field. Strengthen your search for funds with the Foundation Center's digital edition of "Grants for Children & Youth." This new "Grant Guide" reveals the scope of current foundation giving in the field. You'll find descriptions of 37,992 grants…

  15. Grants for Higher Education. 2012 Digital Edition

    Science.gov (United States)

    Foundation Center, 2011

    2011-01-01

    This publication is only available as a downloadable file. See who's giving and getting grants in your field. Strengthen your search for funds with the Foundation Center's digital edition of "Grants for Higher Education." This new "Grant Guide" reveals the scope of current foundation giving in the field. You'll find descriptions of 19,705 grants…

  16. Grants for Employment--2012 Digital Edition

    Science.gov (United States)

    Foundation Center, 2011

    2011-01-01

    This publication is only available as a downloadable file. See who's giving and getting grants in your field. Strengthen your search for funds with the Foundation Center's digital edition of "Grants for Employment." This new "Grant Guide" reveals the scope of current foundation giving in the field. You'll find descriptions of 4,129 grants of…

  17. Genome Editing in Sugarcane: Challenges ahead

    Directory of Open Access Journals (Sweden)

    Chakravarthi Mohan

    2016-10-01

    Full Text Available Genome editing opens new and unique opportunities for researchers to enhance crop production. Until 2013, the zinc finger nucleases (ZFNs and transcription activator-like effector nucleases (TALENs were the key tools used for genome editing applications. The advent of RNA-guided engineered nucleases - the type II clustered regularly interspaced short palindromic repeat (CRISPR/Cas9 (CRISPR-associated system from Streptococcus pyogenes holds great potential since it is simple, effective and more versatile than ZFNs and TALENs. CRISPR/Cas9 system has already been successfully employed in several crop plants. Use of these techniques is in its infant stage in sugarcane. Jung and Altpeter (2016 have reported TALEN mediated approach for the first time to reduce lignin content in sugarcane to make it amenable for biofuel production. This is so far the only report describing genome editing in sugarcane. Large genome size, polyploidy, low transformation efficiency, transgene silencing and lack of high throughput screening techniques are certainly great challenges for genome editing in sugarcane which would be discussed in detail in this review.

  18. Edit Distance to Monotonicity in Sliding Windows

    DEFF Research Database (Denmark)

    Chan, Ho-Leung; Lam, Tak-Wah; Lee, Lap Kei

    2011-01-01

    of a data stream is becoming well-understood over the past few years. Motivated by applications on network quality monitoring, we extend the study to estimating the edit distance to monotonicity of a sliding window covering the w most recent items in the stream for any w ≥ 1. We give a deterministic...

  19. School Law: Cases and Concepts. Seventh Edition.

    Science.gov (United States)

    LaMorte, Michael W.

    This book examines the sizable body of school law that outlines legally defensible decisions. A substantial part of it contains edited, reported, and verbatim decisions. Historical perspective is provided, as well as specific case and statutory law. Chapter 1 discusses sources of law for educators, state school board policies, attorneys-general…

  20. Telling Mathematical Stories with Live Editing

    Science.gov (United States)

    Thomson, Ian

    2017-01-01

    Using "live editing" it is possible to write code that can be run a section at a time. This makes it easier to spot and correct errors. It can also be used to create an interactive mathematical story. This brief article shows how MATLAB software can be used to take the user on a mathematical journey with historical connections.

  1. Qualities of Effective Teachers. 2nd Edition

    Science.gov (United States)

    Stronge, James H.

    2007-01-01

    Thousands of educators who are involved with teacher professional development--from training to hiring, mentoring to supervising--rely on this authoritative book to focus on cultivating teacher qualities that are most apt to raise student achievement. Now, this new edition extends this results-based approach to include teachers who work with…

  2. Introduction to Energy - 2nd Edition

    Science.gov (United States)

    Cassedy, Edward S.; Grossman, Peter Z.

    1998-12-01

    Energy issues such as pollution, resource depletion, global warming, nuclear power and waste are problems that demand timely solutions. This book provides a critical examination of the resources, market forces, and social impacts of modern energy production. The book addresses the dilemmas that have arisen due to society's crucial dependence on energy, particularly fossil fuels, and explores the available alternative energy producing technologies. The second edition has increased emphasis on those issues at the forefront of the current energy debate: energy sustainability, climate change, and the radical restructuring of the power industry due to de-regulation. Assuming no prior technical expertise and avoiding complex mathematical formulation, it is directed at a broad readership. The second edition will follow the first in proving especially useful as a textbook for undergraduate programs in Science, Technology and Society (STS), and as a supplementary text in a variety of courses which touch upon energy studies, including environmental and technology policy, environmental, mineral and business law, energy and resource economics. Fully updated second edition of successful first edition that was adopted on Science, Technology and Society courses Provides a critical examination of all aspects of modern energy production for non-technical readers For a broad readership from a variety of backgrounds

  3. Kids & Family Reading Report™. 6th Edition

    Science.gov (United States)

    Scholastic Inc., 2017

    2017-01-01

    This report presents the 6th Edition of Scholastic's biannual study of children's and parents' attitudes and behaviors about reading. The latest research touches on: (1) Reading Books for Fun; (2) Reading Aloud; (3) Summer Reading; and (4) Favorite Children's Books. This research provides both reasons to celebrate as well as a strong motivation to…

  4. 10 Tempting Image-Editing Tasks

    Science.gov (United States)

    Guhin, Paula

    2009-01-01

    Asking students to manipulate digital photos on the computer is one of the easiest ways the author knows to engage their attention. It's fabulous fun for them and a great teaching tool for educators. In this article, the author presents 10 ways to impress students with image-editing software. These are: (1) filters are fascinating; (2) get a move…

  5. ISEE : An Intuitive Sound Editing Environment

    NARCIS (Netherlands)

    Vertegaal, R.P.H.; Bonis, E.

    1994-01-01

    This article presents ISEE, an intuitive sound editing environment, as a general sound synthesis model based on expert auditory perception and cognition of musical instruments. It discusses the backgrounds of current synthesizer user interface design and related timbre space research. Of the three

  6. A Model for Flexibly Editing CSCL Scripts

    Science.gov (United States)

    Sobreira, Pericles; Tchounikine, Pierre

    2012-01-01

    This article presents a model whose primary concern and design rationale is to offer users (teachers) with basic ICT skills an intuitive, easy, and flexible way of editing scripts. The proposal is based on relating an end-user representation as a table and a machine model as a tree. The table-tree model introduces structural expressiveness and…

  7. Precision genome editing in the CRISPR era.

    Science.gov (United States)

    Salsman, Jayme; Dellaire, Graham

    2017-04-01

    With the introduction of precision genome editing using CRISPR-Cas9 technology, we have entered a new era of genetic engineering and gene therapy. With RNA-guided endonucleases, such as Cas9, it is possible to engineer DNA double strand breaks (DSB) at specific genomic loci. DSB repair by the error-prone non-homologous end-joining (NHEJ) pathway can disrupt a target gene by generating insertions and deletions. Alternatively, Cas9-mediated DSBs can be repaired by homology-directed repair (HDR) using an homologous DNA repair template, thus allowing precise gene editing by incorporating genetic changes into the repair template. HDR can introduce gene sequences for protein epitope tags, delete genes, make point mutations, or alter enhancer and promoter activities. In anticipation of adapting this technology for gene therapy in human somatic cells, much focus has been placed on increasing the fidelity of CRISPR-Cas9 and increasing HDR efficiency to improve precision genome editing. In this review, we will discuss applications of CRISPR technology for gene inactivation and genome editing with a focus on approaches to enhancing CRISPR-Cas9-mediated HDR for the generation of cell and animal models, and conclude with a discussion of recent advances and challenges towards the application of this technology for gene therapy in humans.

  8. Engineered Viruses as Genome Editing Devices.

    Science.gov (United States)

    Chen, Xiaoyu; Gonçalves, Manuel A F V

    2016-03-01

    Genome editing based on sequence-specific designer nucleases, also known as programmable nucleases, seeks to modify in a targeted and precise manner the genetic information content of living cells. Delivering into cells designer nucleases alone or together with donor DNA templates, which serve as surrogate homologous recombination (HR) substrates, can result in gene knockouts or gene knock-ins, respectively. As engineered replication-defective viruses, viral vectors are having an increasingly important role as delivery vehicles for donor DNA templates and designer nucleases, namely, zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated Cas9 (CRISPR-Cas9) nucleases, also known as RNA-guided nucleases (RGNs). We review this dual role played by engineered viral particles on genome editing while focusing on their main scaffolds, consisting of lentiviruses, adeno-associated viruses, and adenoviruses. In addition, the coverage of the growing body of research on the repurposing of viral vectors as delivery systems for genome editing tools is complemented with information regarding their main characteristics, pros, and cons. Finally, this information is framed by a concise description of the chief principles, tools, and applications of the genome editing field as a whole.

  9. CRISPR-Cas9 gene editing

    NARCIS (Netherlands)

    Oude Blenke, Erik; Evers, Martijn J.W.; Mastrobattista, Enrico; Oost, van der John

    2016-01-01

    The CRISPR-Cas9 gene editing system has taken the biomedical science field by storm, initiating rumors about future Nobel Prizes and heating up a fierce patent war, but also making significant scientific impact. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), together with

  10. Genome Editing in Sugarcane: Challenges Ahead.

    Science.gov (United States)

    Mohan, Chakravarthi

    2016-01-01

    Genome editing opens new and unique opportunities for researchers to enhance crop production. Until 2013, the zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) were the key tools used for genome editing applications. The advent of RNA-guided engineered nucleases - the type II clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 (CRISPR-associated) system from Streptococcus pyogenes holds great potential since it is simple, effective and more versatile than ZFNs and TALENs. CRISPR/Cas9 system has already been successfully employed in several crop plants. Use of these techniques is in its infant stage in sugarcane. Jung and Altpeter (2016) have reported TALEN mediated approach for the first time to reduce lignin content in sugarcane to make it amenable for biofuel production. This is so far the only report describing genome editing in sugarcane. Large genome size, polyploidy, low transformation efficiency, transgene silencing and lack of high throughput screening techniques are certainly great challenges for genome editing in sugarcane which would be discussed in detail in this review.

  11. Genome editing in fishes and their applications.

    Science.gov (United States)

    Zhu, Bo; Ge, Wei

    2018-02-01

    There have been revolutionary progresses in genome engineering in the past few years. The newly-emerged genome editing technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats associated with Cas9 (CRISPR/Cas9) have enabled biological scientists to perform efficient and precise targeted genome editing in different species. Fish represent the largest group of vertebrates with many species having values for both scientific research and aquaculture industry. Genome editing technologies have found extensive applications in different fish species for basic functional studies as well asapplied research in such fields as disease modeling and aquaculture. This mini-review focuses on recent advancements and applications of the new generation of genome editing technologies in fish species, with particular emphasis on their applications in understanding reproductive functions because the reproductive axis has been most systematically and best studied among others and its function has been difficult to address with reverse genetics approach. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Evolving edited k-nearest neighbor classifiers.

    Science.gov (United States)

    Gil-Pita, Roberto; Yao, Xin

    2008-12-01

    The k-nearest neighbor method is a classifier based on the evaluation of the distances to each pattern in the training set. The edited version of this method consists of the application of this classifier with a subset of the complete training set in which some of the training patterns are excluded, in order to reduce the classification error rate. In recent works, genetic algorithms have been successfully applied to determine which patterns must be included in the edited subset. In this paper we propose a novel implementation of a genetic algorithm for designing edited k-nearest neighbor classifiers. It includes the definition of a novel mean square error based fitness function, a novel clustered crossover technique, and the proposal of a fast smart mutation scheme. In order to evaluate the performance of the proposed method, results using the breast cancer database, the diabetes database and the letter recognition database from the UCI machine learning benchmark repository have been included. Both error rate and computational cost have been considered in the analysis. Obtained results show the improvement achieved by the proposed editing method.

  13. Feature sensitive multiscale editing on surfaces

    NARCIS (Netherlands)

    Clarenz, U.; Griebel, M.; Rumpf, M.; Schweitzer, M.A.; Telea, A.

    2004-01-01

    A novel editing method for large triangular meshes is presented. We detect surface features, such as edge and corners, by computing local zero and first surface moments, using a robust and noise resistant method. The feature detection is encoded in a finite element matrix, passed to an algebraic

  14. Collecting and Interpreting Qualitative Materials. Third Edition

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna, Ed.

    2007-01-01

    This book is the third volume of the paperback versions of "The SAGE Handbook of Qualitative Research, Third Edition." This portion of the handbook considers the tasks of collecting, analyzing, and interpreting empirical materials, and comprises the Handbook's Parts IV ("Methods of Collecting and Analyzing Empirical Materials") and V ("The Art and…

  15. The Landscape of Qualitative Research. Third Edition

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna, Ed.

    2007-01-01

    This book, the first volume of the paperback versions of the "The SAGE Handbook of Qualitative Research, Third Edition," takes a look at the field from a broadly theoretical perspective, and is composed of the Handbook's Parts I ("Locating the Field"), II ("Major Paradigms and Perspectives"), and VI ("The Future of Qualitative Research"). "The…

  16. Handbook of Qualitative Research. Second Edition.

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    This handbook's second edition represents the state of the art for the theory and practice of qualitative inquiry. It features eight new topics, including autoethnography, critical race theory, applied ethnography, queer theory, and "testimonio"every chapter in the handbook has been thoroughly revised and updated. The book…

  17. Home Study Course Development Handbook. Second Edition.

    Science.gov (United States)

    Lambert, Michael P., Ed.; Welch, Sally R., Ed.

    Intended to help developers of home study courses and their directors of education create good correspondence courses, this document updates the 1980 edition and was developed by members of the National Home Study Council's Research and Educational Standards Committee. The document begins with photographs and biographies of its authors. The…

  18. Kids & Family Reading Report™. 5th Edition

    Science.gov (United States)

    Scholastic Inc., 2015

    2015-01-01

    This report presents the 5th Edition of Scholastic's biannual study of children's and parents' attitudes and behaviors about reading. The latest research touches on reading aloud to children of all ages, the impact of reading independently for fun at school and at home, the importance of frequent reading, and the books children want most to read.…

  19. Nanoparticles for Site Specific Genome Editing

    Science.gov (United States)

    McNeer, Nicole Ali

    Triplex-forming peptide nucleic acids (PNAs) can be used to coordinate the recombination of short 50-60 by "donor DNA" fragments into genomic DNA, resulting in site-specific correction of genetic mutations or the introduction of advantageous genetic modifications. Site-specific gene editing in hematopoietic stem and progenitor cells (HSPCs) could result in treatment or cure of inherited disorders of the blood such as beta-thalassemia. Gene editing in HSPCs and differentiated T cells could help combat HIV/AIDs by modifying receptors, such as CCR5, necessary for R5-tropic HIV entry. However, translation of genome modification technologies to clinical practice is limited by challenges in intracellular delivery, especially in difficult-to-transfect hematolymphoid cells. In vivo gene editing could also provide novel treatment for systemic monogenic disorders such as cystic fibrosis, an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor. Here, we have engineered biodegradable nanoparticles to deliver oligonucleotides for site-specific genome editing of disease-relevant genes in human cells, with high efficiency, low toxicity, and editing of clinically relevant cell types. We designed nanoparticles to edit the human beta-globin and CCR5 genes in hematopoietic cells. We show that poly(lactic-co-glycolic acid) (PLGA) nanoparticles can delivery PNA and donor DNA for site-specific gene modification in human hematopoietic cells in vitro and in vivo in NOD-scid IL2rgammanull mice. Nanoparticles delivered by tail vein localized to hematopoietic compartments in the spleen and bone marrow of humanized mice, resulting in modification of the beta-globin and CCR5 genes. Modification frequencies ranged from 0.005 to 20% of cells depending on the organ and cell type, without detectable toxicity. This project developed highly versatile methods for delivery of therapeutics to hematolymphoid cells and hematopoietic stem cells, and will help to

  20. Interactions of cultures and top people of Wikipedia from ranking of 24 language editions.

    Science.gov (United States)

    Eom, Young-Ho; Aragón, Pablo; Laniado, David; Kaltenbrunner, Andreas; Vigna, Sebastiano; Shepelyansky, Dima L

    2015-01-01

    Wikipedia is a huge global repository of human knowledge that can be leveraged to investigate interwinements between cultures. With this aim, we apply methods of Markov chains and Google matrix for the analysis of the hyperlink networks of 24 Wikipedia language editions, and rank all their articles by PageRank, 2DRank and CheiRank algorithms. Using automatic extraction of people names, we obtain the top 100 historical figures, for each edition and for each algorithm. We investigate their spatial, temporal, and gender distributions in dependence of their cultural origins. Our study demonstrates not only the existence of skewness with local figures, mainly recognized only in their own cultures, but also the existence of global historical figures appearing in a large number of editions. By determining the birth time and place of these persons, we perform an analysis of the evolution of such figures through 35 centuries of human history for each language, thus recovering interactions and entanglement of cultures over time. We also obtain the distributions of historical figures over world countries, highlighting geographical aspects of cross-cultural links. Considering historical figures who appear in multiple editions as interactions between cultures, we construct a network of cultures and identify the most influential cultures according to this network.

  1. Interactions of cultures and top people of Wikipedia from ranking of 24 language editions.

    Directory of Open Access Journals (Sweden)

    Young-Ho Eom

    Full Text Available Wikipedia is a huge global repository of human knowledge that can be leveraged to investigate interwinements between cultures. With this aim, we apply methods of Markov chains and Google matrix for the analysis of the hyperlink networks of 24 Wikipedia language editions, and rank all their articles by PageRank, 2DRank and CheiRank algorithms. Using automatic extraction of people names, we obtain the top 100 historical figures, for each edition and for each algorithm. We investigate their spatial, temporal, and gender distributions in dependence of their cultural origins. Our study demonstrates not only the existence of skewness with local figures, mainly recognized only in their own cultures, but also the existence of global historical figures appearing in a large number of editions. By determining the birth time and place of these persons, we perform an analysis of the evolution of such figures through 35 centuries of human history for each language, thus recovering interactions and entanglement of cultures over time. We also obtain the distributions of historical figures over world countries, highlighting geographical aspects of cross-cultural links. Considering historical figures who appear in multiple editions as interactions between cultures, we construct a network of cultures and identify the most influential cultures according to this network.

  2. Interactions of Cultures and Top People of Wikipedia from Ranking of 24 Language Editions

    Science.gov (United States)

    Eom, Young-Ho; Aragón, Pablo; Laniado, David; Kaltenbrunner, Andreas; Vigna, Sebastiano; Shepelyansky, Dima L.

    2015-01-01

    Wikipedia is a huge global repository of human knowledge that can be leveraged to investigate interwinements between cultures. With this aim, we apply methods of Markov chains and Google matrix for the analysis of the hyperlink networks of 24 Wikipedia language editions, and rank all their articles by PageRank, 2DRank and CheiRank algorithms. Using automatic extraction of people names, we obtain the top 100 historical figures, for each edition and for each algorithm. We investigate their spatial, temporal, and gender distributions in dependence of their cultural origins. Our study demonstrates not only the existence of skewness with local figures, mainly recognized only in their own cultures, but also the existence of global historical figures appearing in a large number of editions. By determining the birth time and place of these persons, we perform an analysis of the evolution of such figures through 35 centuries of human history for each language, thus recovering interactions and entanglement of cultures over time. We also obtain the distributions of historical figures over world countries, highlighting geographical aspects of cross-cultural links. Considering historical figures who appear in multiple editions as interactions between cultures, we construct a network of cultures and identify the most influential cultures according to this network. PMID:25738291

  3. Genome editing and transcriptional repression in Pseudomonas putida KT2440 via the type II CRISPR system.

    Science.gov (United States)

    Sun, Jun; Wang, Qingzhuo; Jiang, Yu; Wen, Zhiqiang; Yang, Lirong; Wu, Jianping; Yang, Sheng

    2018-03-13

    The soil bacterium Pseudomonas putida KT2440 is a "generally recognized as safe"-certified strain with robust property and versatile metabolism. Thus, it is an ideal candidate for synthetic biology, biodegradation, and other biotechnology applications. The known genome editing approaches of Pseudomonas are suboptimal; thus, it is necessary to develop a high efficiency genome editing tool. In this study, we established a fast and convenient CRISPR-Cas9 method in P. putida KT2440. Gene deletion, gene insertion and gene replacement could be achieved within 5 days, and the mutation efficiency reached > 70%. Single nucleotide replacement could be realized, overcoming the limitations of protospacer adjacent motif sequences. We also applied nuclease-deficient Cas9 binding at three locations upstream of enhanced green fluorescent protein (eGFP) for transcriptional inhibition, and the expression intensity of eGFP reduced to 28.5, 29.4, and 72.1% of the control level, respectively. Furthermore, based on this CRISPR-Cas9 system, we also constructed a CRISPR-Cpf1 system, which we validated for genome editing in P. putida KT2440. In this research, we established CRISPR based genome editing and regulation control systems in P. putida KT2440. These fast and efficient approaches will greatly facilitate the application of P. putida KT2440.

  4. The construction project manager in South Africa: Analysis of ...

    African Journals Online (AJOL)

    Project management knowledge areas essential to project managers included the nine PMBOK knowledge areas from the PMI PMBOK guide, 4th edition 2008, four additional PMI Construction extension to the PMBOK areas, experience as well as built environment-specific knowledge. This study was limited to the nine ...

  5. C-to-U editing and site-directed RNA editing for the correction of genetic mutations.

    Science.gov (United States)

    Vu, Luyen Thi; Tsukahara, Toshifumi

    2017-07-24

    Cytidine to uridine (C-to-U) editing is one type of substitutional RNA editing. It occurs in both mammals and plants. The molecular mechanism of C-to-U editing involves the hydrolytic deamination of a cytosine to a uracil base. C-to-U editing is mediated by RNA-specific cytidine deaminases and several complementation factors, which have not been completely identified. Here, we review recent findings related to the regulation and enzymatic basis of C-to-U RNA editing. More importantly, when C-to-U editing occurs in coding regions, it has the power to reprogram genetic information on the RNA level, therefore it has great potential for applications in transcript repair (diseases related to thymidine to cytidine (T>C) or adenosine to guanosine (A>G) point mutations). If it is possible to manipulate or mimic C-to-U editing, T>C or A>G genetic mutation-related diseases could be treated. Enzymatic and non-enzymatic site-directed RNA editing are two different approaches for mimicking C-to-U editing. For enzymatic site-directed RNA editing, C-to-U editing has not yet been successfully performed, and in theory, adenosine to inosine (A-to-I) editing involves the same strategy as C-to-U editing. Therefore, in this review, for applications in transcript repair, we will provide a detailed overview of enzymatic site-directed RNA editing, with a focus on A-to-I editing and non-enzymatic site-directed C-to-U editing.

  6. Outcomes of Surgical and Non-Surgical Treatment for Sixth Nerve Palsy

    Directory of Open Access Journals (Sweden)

    Abbas Bagheri

    2010-01-01

    Full Text Available Purpose: To report the outcomes of surgical and non-surgical treatment in sixth nerve paresis and palsy. Methods: This retrospective study was performed on hospital records of 33 consecutive patients (37 eyes with sixth nerve dysfunction who were referred to Labbafinejad Medical Center from September 1996 to September 2006, and underwent surgical procedures or botulinum toxin injection. Patients were divided into three groups: group A had muscle surgery without transposition, group B underwent transposition procedures and group C received Botulinum toxin injection. Results: Overall, 33 patients including 19 male and 14 female subjects with mean age of 20.4±17.2 years (range, 6 months to 66 years were studied. Eye deviation improved from 50.3±16.8 to 6.0±9.8 prism diopters (PD after the first operation and to 2.5±5.0 PD after the second operation in group A, from 56.9±24.3 to 5.5±16.0 PD after the first procedure and to almost zero following the second in group B, and from 44.3±10.5 to 15.0±20.0 PD 6 months following botulinum toxin injection in group C. Head posture and limitation of motility also improved significantly in all three groups. The overall rate of reoperations was 21%. Conclusions: Various procedures are effective for treatment of sixth nerve dysfunction; all improve ocular deviation, head turn and abduction deficit. The rate of reoperation is not high when treatment is appropriately selected according to clinical condition.

  7. Outcomes of surgical and non-surgical treatment for sixth nerve palsy.

    Science.gov (United States)

    Bagheri, Abbas; Babsharif, Babak; Abrishami, Mohammad; Salour, Hossein; Aletaha, Maryam

    2010-01-01

    To report the outcomes of surgical and non-surgical treatment in sixth nerve paresis and palsy. This retrospective study was performed on hospital records of 33 consecutive patients (37 eyes) with sixth nerve dysfunction who were referred to Labbafinejad Medical Center from September 1996 to September 2006, and underwent surgical procedures or botulinum toxin injection. Patients were divided into three groups: group A had muscle surgery without transposition, group B underwent transposition procedures and group C received Botulinum toxin injection. Overall, 33 patients including 19 male and 14 female subjects with mean age of 20.4±17.2 years (range, 6 months to 66 years) were studied. Eye deviation improved from 50.3±16.8 to 6.0±9.8 prism diopters (PD) after the first operation and to 2.5±5.0 PD after the second operation in group A, from 56.9±24.3 to 5.5±16.0 PD after the first procedure and to almost zero following the second in group B, and from 44.3±10.5 to 15.0±20.0 PD 6 months following botulinum toxin injection in group C. Head posture and limitation of motility also improved significantly in all three groups. The overall rate of reoperations was 21%. Various procedures are effective for treatment of sixth nerve dysfunction; all improve ocular deviation, head turn and abduction deficit. The rate of reoperation is not high when treatment is appropriately selected according to clinical condition.

  8. Forty-sixth supplement to the American Ornithologists' Union Check-list of North American Birds

    Science.gov (United States)

    Banks, R.C.; Cicero, C.; Dunn, J.L.; Kratter, A.W.; Rasmussen, P.C.; Remsen, J.V.; Rising, J.D.; Stotz, D.F.

    2005-01-01

    This is the fifth Supplement since publication of the 7th edition of the Check-list of North American Birds (American Ornithologists' Union [AOU] 1998). It summarizes decisions made by the AOU's Committee on Classification and Nomenclature between 1 January and 31 December 2004.

  9. The 1967 June War: Soviet Naval Diplomacy and the Sixth Fleet - A Reappraisal,

    Science.gov (United States)

    1977-10-01

    2 SSM) 2 Kildin (1 SSM) 1 Kotlin (1+2 SAM) 7 Kotlin 9 Skoryy 10 Riga 5 Mikka 5 Petya 23 Poti 17 Kronshtadt 6 OSA 10 Komar 184 Other 11...class DDGS in the Mediterranean until 31 August, 1 Soviet Kashin class DLG in the Med- iterranean until 13 SEP; 1 modified Soviet Kotlin class DD...President Johnson orders th« Sixth Fleet eastwards, and later flee* reverses course. Kotlin 514 breaks off surveillance of the USS SARATOGA at midday

  10. Sixth International Conference on Precipitation: Predictability of Rainfall at the Various Scales. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    None

    1998-06-29

    This volume contains abstracts of the papers presented at the Sixth International Conference on Precipitation: Predictability of Rainfall at the various scales, held at the Mauna Lani Bay and Bungalows, Hawaii, June 29 - July 1, 1998. The main goal of the conference was to bring together meteorologists, hydrologists, mathematicians, physicists, statisticians, and all others who are interested in fundamental principles governing the physical processes of precipitation. The results of the previous conferences have been published in issues of the Journal of Geophysical Research and Journal of Applied Meteorology. A similar format is planned for papers of this conference.

  11. Sixth Microgravity Fluid Physics and Transport Phenomena Conference: Exposition Topical Areas 1-6. Volume 2

    Science.gov (United States)

    Singh, Bhim (Compiler)

    2002-01-01

    The Sixth Microgravity Fluid Physics and Transport Phenomena Conference provides the scientific community the opportunity to view the current scope of the Microgravity Fluid Physics and Transport Phenomena Program, current research opportunities, and plans for the near future. The conference focuses not only on fundamental research but also on applications of this knowledge towards enabling future space exploration missions. A whole session dedicated to biological fluid physics shows increased emphasis that the program has placed on interdisciplinary research. The conference includes invited plenary talks, technical paper presentations, poster presentations, and exhibits. This CP (conference proceeding) is a compilation of the abstracts, presentations, and posters presented at the conference.

  12. Numerical solution of sixth-order boundary-value problems using Legendre wavelet collocation method

    Science.gov (United States)

    Sohaib, Muhammad; Haq, Sirajul; Mukhtar, Safyan; Khan, Imad

    2018-03-01

    An efficient method is proposed to approximate sixth order boundary value problems. The proposed method is based on Legendre wavelet in which Legendre polynomial is used. The mechanism of the method is to use collocation points that converts the differential equation into a system of algebraic equations. For validation two test problems are discussed. The results obtained from proposed method are quite accurate, also close to exact solution, and other different methods. The proposed method is computationally more effective and leads to more accurate results as compared to other methods from literature.

  13. Sixth Graders Benefit from Educational Software when Learning about Fractions: A Controlled Classroom study

    Directory of Open Access Journals (Sweden)

    Susanne Scharnagl

    2014-01-01

    Full Text Available This study analyses the effectiveness of an educational web-based software package for teaching mathematics in schools. In all, 864 sixth graders and their teachers took part in the controlled study. Students learned the addition and subtraction of fractions with (intervention group; n = 469 or without (control group; n = 395 the support of the educational software. Compared to the controls, students who used the software showed better results in the post-test. Gains were dose dependent and particularly marked in high-ability students and students with lower scores of math anxiety.

  14. Isolated sixth nerve palsy from hemorrhage of a pontine cavernous malformation.

    Science.gov (United States)

    Mallery, Robert M; Klein, Joshua P; Pless, Misha L

    2012-12-01

    A 32-year-old woman who developed binocular horizontal diplopia was found to have an isolated fascicular sixth nerve palsy secondary to hemorrhage of a cavernous malformation within the left pontine tegmentum. There was sparing of the paramedian pontine reticular formation and absence of a horizontal gaze palsy. The natural history of cavernous malformations and a mechanism by which hemorrhage of these vascular lesions may produce minimal neurologic signs, including isolated ocular motor cranial nerve palsies, is discussed. Magnetic resonance imaging (MRI) that includes susceptibility-weighted sequences leads to their accurate diagnosis.

  15. Sixth cranial nerve palsy following closed head injury in a child.

    Science.gov (United States)

    Hollis, G J

    1997-01-01

    A five year old female had an isolated abducens nerve palsy following closed head injury. There was no associated skull fracture, haematoma, or other cranial nerve injury. The significance, frequency, and differential diagnosis of traumatic sixth cranial nerve injury is discussed, particularly in paediatric patients. Management is symptomatic; occlusion with an eye pad may be used if diplopia is significant. In young children alternate day occlusion of each eye will help prevent amblyopia. Most cases improve within three months and many resolve by six months. Residual palsy at six months is likely to be permanent and surgical treatment may be needed. PMID:9193985

  16. Pneumocephalus and Sixth Nerve Palsy after Epidural Steroid Injection: Case Report and Review of the Literature.

    Science.gov (United States)

    Li, Wendy F; Kovacs, Kyle; Fisayo, Adeniyi A

    2017-11-01

    Pneumocephalus has been described as an unintended outcome after epidural injections. However, oculomotor palsy from pneumocephalus after epidural injection is very rare. We report a case of pneumocephalus-induced sixth nerve palsies and diplopia in an 87-year-old woman after epidural steroid injection. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Pneumocephalus-induced oculomotor palsy is a rare complication after epidural injection, a commonly performed medical procedure. Knowledge of this presentation will help emergency physicians distinguish between this entity and other causes of neurologic deficits. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Modelling Constructs

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2009-01-01

    , these notations have been extended in order to increase expressiveness and to be more competitive. This resulted in an increasing number of notations and formalisms for modelling business processes and in an increase of the different modelling constructs provided by modelling notations, which makes it difficult......There are many different notations and formalisms for modelling business processes and workflows. These notations and formalisms have been introduced with different purposes and objectives. Later, influenced by other notations, comparisons with other tools, or by standardization efforts...... to compare modelling notations and to make transformations between them. One of the reasons is that, in each notation, the new concepts are introduced in a different way by extending the already existing constructs. In this chapter, we go the opposite direction: We show that it is possible to add most...

  18. Airship construction

    Science.gov (United States)

    Roda, J.

    1975-01-01

    Forty-four years ago the first successful metal airship was completed and delivered to the United States Navy, the ZMC-2. Between those years and the present, very little effort or serious consideration has been given to the manufacture, design, construction, or economic impact of airships. It is important to retain and exploit the small but continually diminishing pool of airship talent that will expedite the success of the United States in what is now a pioneering venture. The relative simplicity of airship construction, utilizing the tremendous technical advances of the last 44 years, leads to the conclusion that this form of transportation holds great promise for reducing costs of military missions and improving the international competitive position of the United States in commercial applications.

  19. IMRT fluence map editing to control hot and cold spots

    International Nuclear Information System (INIS)

    Taylor Cook, J.; Tobler, Matt; Leavitt, Dennis D.; Watson, Gordon

    2005-01-01

    Manually editing intensity-modulated radiation therapy (IMRT) fluence maps effectively controls hot and cold spots that the IMRT optimization cannot control. Many times, re-optimizing does not reduce the hot spots or increase the cold spots. In fact, re-optimizing only places the hot and cold spots in different locations. Fluence-map editing provides manual control of dose delivery and provides the best treatment plan possible. Several IMRT treatments were planned using the Varian Eclipse planning system. We compare the effects on dose distributions between fluence-map editing and re-optimization, discuss techniques for fluence-map editing, and analyze differences between fluence editing on one beam vs. multiple beams. When editing a beam's fluence map, it is essential to choose a beam that least affects dose to the tumor and critical structures. Editing fluence maps gives an advantage in treatment planning and provides controlled delivery of IMRT dose

  20. Directory of Adult Education Periodicals. Sixth Revised Edition = Repertoire des Periodiques sur l'Education des Adultes. Sixieme Edition Revisee = Repertorio de Periodicos sobre Educacion de Adultos. Sexta Edicion Revisada.

    Science.gov (United States)

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Literacy, Adult Education and Rural Development.

    This directory lists approximately 175 adult education periodicals published in Africa, Arab states, Asia and the Pacific, Europe, North America, Latin America and the Caribbean, and other international areas. Within each category, periodicals are further divided into the individual countries in which they are published. Each entry may provide…

  1. A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation1[OPEN

    Science.gov (United States)

    Lowder, Levi G.; Zhang, Dengwei; Baltes, Nicholas J.; Paul, Joseph W.; Tang, Xu; Zheng, Xuelian; Voytas, Daniel F.; Hsieh, Tzung-Fu; Zhang, Yong; Qi, Yiping

    2015-01-01

    The relative ease, speed, and biological scope of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated Protein9 (Cas9)-based reagents for genomic manipulations are revolutionizing virtually all areas of molecular biosciences, including functional genomics, genetics, applied biomedical research, and agricultural biotechnology. In plant systems, however, a number of hurdles currently exist that limit this technology from reaching its full potential. For example, significant plant molecular biology expertise and effort is still required to generate functional expression constructs that allow simultaneous editing, and especially transcriptional regulation, of multiple different genomic loci or multiplexing, which is a significant advantage of CRISPR/Cas9 versus other genome-editing systems. To streamline and facilitate rapid and wide-scale use of CRISPR/Cas9-based technologies for plant research, we developed and implemented a comprehensive molecular toolbox for multifaceted CRISPR/Cas9 applications in plants. This toolbox provides researchers with a protocol and reagents to quickly and efficiently assemble functional CRISPR/Cas9 transfer DNA constructs for monocots and dicots using Golden Gate and Gateway cloning methods. It comes with a full suite of capabilities, including multiplexed gene editing and transcriptional activation or repression of plant endogenous genes. We report the functionality and effectiveness of this toolbox in model plants such as tobacco (Nicotiana benthamiana), Arabidopsis (Arabidopsis thaliana), and rice (Oryza sativa), demonstrating its utility for basic and applied plant research. PMID:26297141

  2. A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation.

    Science.gov (United States)

    Lowder, Levi G; Zhang, Dengwei; Baltes, Nicholas J; Paul, Joseph W; Tang, Xu; Zheng, Xuelian; Voytas, Daniel F; Hsieh, Tzung-Fu; Zhang, Yong; Qi, Yiping

    2015-10-01

    The relative ease, speed, and biological scope of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated Protein9 (Cas9)-based reagents for genomic manipulations are revolutionizing virtually all areas of molecular biosciences, including functional genomics, genetics, applied biomedical research, and agricultural biotechnology. In plant systems, however, a number of hurdles currently exist that limit this technology from reaching its full potential. For example, significant plant molecular biology expertise and effort is still required to generate functional expression constructs that allow simultaneous editing, and especially transcriptional regulation, of multiple different genomic loci or multiplexing, which is a significant advantage of CRISPR/Cas9 versus other genome-editing systems. To streamline and facilitate rapid and wide-scale use of CRISPR/Cas9-based technologies for plant research, we developed and implemented a comprehensive molecular toolbox for multifaceted CRISPR/Cas9 applications in plants. This toolbox provides researchers with a protocol and reagents to quickly and efficiently assemble functional CRISPR/Cas9 transfer DNA constructs for monocots and dicots using Golden Gate and Gateway cloning methods. It comes with a full suite of capabilities, including multiplexed gene editing and transcriptional activation or repression of plant endogenous genes. We report the functionality and effectiveness of this toolbox in model plants such as tobacco (Nicotiana benthamiana), Arabidopsis (Arabidopsis thaliana), and rice (Oryza sativa), demonstrating its utility for basic and applied plant research. © 2015 American Society of Plant Biologists. All Rights Reserved.

  3. Compensating Hand Function in Chronic Stroke Patients Through the Robotic Sixth Finger.

    Science.gov (United States)

    Salvietti, Gionata; Hussain, Irfan; Cioncoloni, David; Taddei, Sabrina; Rossi, Simone; Prattichizzo, Domenico

    2017-02-01

    A novel solution to compensate hand grasping abilities is proposed for chronic stroke patients. The goal is to provide the patients with a wearable robotic extra-finger that can be worn on the paretic forearm by means of an elastic band. The proposed prototype, the Robotic Sixth Finger, is a modular articulated device that can adapt its structure to the grasped object shape. The extra-finger and the paretic hand act like the two parts of a gripper cooperatively holding an object. We evaluated the feasibility of the approach with four chronic stroke patients performing a qualitative test, the Frenchay Arm Test. In this proof of concept study, the use of the Robotic Sixth Finger has increased the total score of the patients by two points in a five points scale. The subjects were able to perform the two grasping tasks included in the test that were not possible without the robotic extra-finger. Adding a robotic opposing finger is a very promising approach that can significantly improve the functional compensation of the chronic stroke patient during everyday life activities.

  4. Self-Concept and Sport Participation in Sixth Grade Basic School Students

    Directory of Open Access Journals (Sweden)

    Špela Virag

    2016-04-01

    Full Text Available The purpose of the study was to examine self-concept in relation to sport participation among basic school children. The sample included 109 sixth grade students of different Slovenian basic schools. The participants completed the Slovenian version of the SelfPerception Profile for Children – SPPC. The results show significant gender differences in some specific components of self-concept. Boys exhibited higher scores in perceived physical appearance and athletic competence, whereas girls exhibited higher levels in perceived behavioural conduct. Mean values show that students, engaged in organized sport practice, reported higher scores in all self-concept subscales than their inactive peers, although significant differences between these two groups were found in perceived scholastic competence and athletic competence. The study offers a detailed insight into the multidimensional self-perceptions of sixth grade basic school students. The results highlight the importance of physical/sports activity in the self-concept development and can be useful in promoting an active lifestyle among youth.

  5. The solution of the sixth Hilbert problem: the ultimate Galilean revolution.

    Science.gov (United States)

    D'Ariano, Giacomo Mauro

    2018-04-28

    I argue for a full mathematization of the physical theory, including its axioms, which must contain no physical primitives. In provocative words: 'physics from no physics'. Although this may seem an oxymoron, it is the royal road to keep complete logical coherence, hence falsifiability of the theory. For such a purely mathematical theory the physical connotation must pertain only the interpretation of the mathematics, ranging from the axioms to the final theorems. On the contrary, the postulates of the two current major physical theories either do not have physical interpretation (as for von Neumann's axioms for quantum theory), or contain physical primitives as 'clock', 'rigid rod', 'force', 'inertial mass' (as for special relativity and mechanics). A purely mathematical theory as proposed here, though with limited (but relentlessly growing) domain of applicability, will have the eternal validity of mathematical truth. It will be a theory on which natural sciences can firmly rely. Such kind of theory is what I consider to be the solution of the sixth Hilbert problem. I argue that a prototype example of such a mathematical theory is provided by the novel algorithmic paradigm for physics, as in the recent information-theoretical derivation of quantum theory and free quantum field theory.This article is part of the theme issue 'Hilbert's sixth problem'. © 2018 The Author(s).

  6. Suicidal behavior on Axis VI: clinical data supporting a sixth Axis for DSM-V.

    Science.gov (United States)

    Van Orden, Kimberly A; Witte, Tracy K; Holm-Denoma, Jill; Gordon, Kathryn H; Joiner, Thomas E

    2011-01-01

    Oquendo and colleagues (Oquendo, Baca-García, Mann, & Giner, 2008; Oquendo & Currier, 2009) recommend that DSM-V emphasize suicide risk assessment on a sixth axis, thereby increasing regularity of suicide risk assessments. We propose that evidence of nonredundancy with Axis V - Global Assessment of Functioning (GAF) is one piece of data that can serve as a starting point for a line of research establishing incremental predictive utility for a separate suicide risk assessment in the DSM framework. A standardized suicide risk assessment protocol, measures of depressive, anxious, and eating disordered symptomatology, as well as an index of comorbidity were administered to a sample of 412 adult outpatients. Our data indicate that data from standardized suicide risk assessments are associated with indices of symptomatology severity as well as comorbidity, controlling for GAF. These results support the nonredundancy of the assessments and suggest the utility of longitudinal investigations of the predictive utility of a sixth DSM axis in the assessment of suicide risk.

  7. Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population losses and declines.

    Science.gov (United States)

    Ceballos, Gerardo; Ehrlich, Paul R; Dirzo, Rodolfo

    2017-07-25

    The population extinction pulse we describe here shows, from a quantitative viewpoint, that Earth's sixth mass extinction is more severe than perceived when looking exclusively at species extinctions. Therefore, humanity needs to address anthropogenic population extirpation and decimation immediately. That conclusion is based on analyses of the numbers and degrees of range contraction (indicative of population shrinkage and/or population extinctions according to the International Union for Conservation of Nature) using a sample of 27,600 vertebrate species, and on a more detailed analysis documenting the population extinctions between 1900 and 2015 in 177 mammal species. We find that the rate of population loss in terrestrial vertebrates is extremely high-even in "species of low concern." In our sample, comprising nearly half of known vertebrate species, 32% (8,851/27,600) are decreasing; that is, they have decreased in population size and range. In the 177 mammals for which we have detailed data, all have lost 30% or more of their geographic ranges and more than 40% of the species have experienced severe population declines (>80% range shrinkage). Our data indicate that beyond global species extinctions Earth is experiencing a huge episode of population declines and extirpations, which will have negative cascading consequences on ecosystem functioning and services vital to sustaining civilization. We describe this as a "biological annihilation" to highlight the current magnitude of Earth's ongoing sixth major extinction event.

  8. Recurrent and self-remitting sixth cranial nerve palsy: pathophysiological insight from skull base chondrosarcoma.

    Science.gov (United States)

    Frassanito, Paolo; Massimi, Luca; Rigante, Mario; Tamburrini, Gianpiero; Conforti, Giulio; Di Rocco, Concezio; Caldarelli, Massimo

    2013-12-01

    Palsy of the abducens nerve is a neurological sign that has a wide range of causes due to the nerve's extreme vulnerability. Need of immediate neuroimaging is a matter of debate in the literature, despite the risks of delaying the diagnosis of a skull base tumor. The authors present 2 cases of skull base tumors in which the patients presented with recurrent and self-remitting episodes of sixth cranial nerve palsy (SCNP). In both cases the clinical history exceeded 1 year. In a 17-year-old boy the diagnosis was made because of the onset of headache when the tumor reached a very large size. In a 12-year-old boy the tumor was incidentally diagnosed when it was still small. In both patients surgery was performed and the postoperative course was uneventful. Pathological diagnosis of the tumor was consistent with that of a chondrosarcoma in both cases. Recurrent self-remitting episodes of SCNP, resembling transitory ischemic attacks, may be the presenting sign of a skull base tumor due to the anatomical relationships of these lesions with the petroclival segment of the sixth cranial nerve. Physicians should promptly recommend neuroimaging studies if SCNP presents with this peculiar course.

  9. Augmented vertical recti transposition with intraoperative botulinum toxin for complete and chronic sixth nerve palsy.

    Science.gov (United States)

    Nabie, R; Andalib, D

    2017-01-01

    PurposeTo evaluate the results of augmented vertical rectus muscle transposition (VRT) with intraoperative botulinum toxin (BTX) for complete and chronic sixth nerve palsy.MethodsDuring a 10-year period (2004-2014) all patients with chronic and complete sixth nerve palsy and contracted medial rectus (MR) who underwent augmented VRT and BTX injection into the MR enrolled in this study.ResultsIn total, 29 patients (5 bilateral) were enrolled in this study. Preoperative deviation was 45±17.5 Prism Diopter (PD), which was improved to -3.1±13.2 after the operation (P<0.001). Mean preoperative and postoperative abduction limitation was -4.4±1.1 and -1.8±0.9, respectively (P<0.001). The success rate was 76% (deviation within 10 PD of orthotropia). Four patients (13.7%) had hypotropia. In 19 patients with preoperative deviation ≤45 PD, four patients had consecutive exotropia.ConclusionIntraoperative BTX injection with augmented vertical rectus transposition is an effective procedure. In deviation ≤45 there is a risk of overcorrection.

  10. Superior rectus transposition combined with medial rectus recession for Duane syndrome and sixth nerve palsy

    Science.gov (United States)

    Mehendale, Reshma A.; Dagi, Linda R.; Wu, Carolyn; Ledoux, Danielle; Johnston, Suzanne; Hunter, David G.

    2013-01-01

    Objective Vertical rectus transposition (VRT) is used to treat abduction limitation, but new vertical deviations and anterior segment ischemia are concerns. Johnston and Crouch described superior rectus transposition (SRT), a procedure in which only the superior rectus muscle is transposed temporally. We describe our results using augmented temporal SRT with adjustable medial rectus muscle recession (MRc) for treatment of Duane syndrome I (DS) and sixth nerve palsy. Methods Retrospective surgical case review of patients undergoing the SRT procedure. Pre- and post-operative orthoptic measurements were recorded. Minimum follow-up was 6 weeks. Main outcome measures included angle of esotropia in primary position and the angle of head turn. Secondary outcomes included duction limitation, stereopsis, and new vertical deviations. Results The review identified seventeen patients (10 with DS and 7 with sixth nerve palsy). SRT+MRc improved esotropia [from 44 PD to 10.1 PD (psixth nerve palsy and 0/10 DS patients. No patient described torsional diplopia. Conclusions SRT allows for the option of simultaneous medial rectus recession in patients with severe abduction imitation who require transposition surgery. SRT+MRc improved esotropia, head position, abduction limitation, and stereopsis without inducing torsional diplopia. PMID:22332212

  11. The dispersion of pederasty and the athletic revolution in sixth-century BC Greece.

    Science.gov (United States)

    Scanlon, Thomas F

    2005-01-01

    Dorian Crete and Thebes are conventionally seen by ancient sources as the originators of pederasty; modern historians see support for this view in Dorian male-centered militarism and sexual segregation in upbringing. Here athletic culture, including training, nudism, and competition, is argued to be a chief 'trigger' for the emergence of pederasty in Sparta and its relatively rapid spread to other Greek states in the seventh to sixth centuries BC. Athletic nudity, in particular, was not a device to enforce civic egalitarianism, as some have argued, but is a persistently erotic incentive that reinforces hegemonic maleness and advertises the individual's virtuous exercise of restraint. In particular, Sparta is found to be the likely source of generalized athletic nudity combined with open pederasty in the early seventh century BC. Nudism in Greek art is erotically charged and not, as others argue, simply a gender marker in the seventh century. Generalized athletic nudity spread to other Greek states emulating the successful Spartan model by the 'athletic revolution' of the early sixth century. With athletic nudity, open pederasty, again following Sparta, was fostered.

  12. Achievement report (edition B) for fiscal 1999 on development of technology to manufacture coal gas for fuel cells. Studies by using pilot test facilities (Volumes for equipment fabrication and constructions, and trial run design); 1999 nendo seika hokokusho (B ban). Nenryo denchi you sekitan gas seizo gijutsu kaihatsu - Pilot setsubi ni yoru kenkyu (kisokoji kiki seisaku hen shiunten sekkei hen)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    With an objective to develop a coal gas manufacturing system for fuel cells, research and development has been performed on a oxygen-blown coal gasifier and researches on a technology to purify gases for fuel cells. This paper summarizes the achievements in fiscal 1999. The current fiscal year has performed, among other the pilot plant construction works, execution of the above-the-ground constructions for the operation center and compressor room building, construction of the cooling water tanks, and partial improvement of roads in the plant site. In the gasifier facilities, items of equipment were fabricated, some of the outsourced articles were procured, and the installations thereof were carried out. For the gas purifying equipment, installation of the gas analyzer room was executed. In the trial run design, discussions were given on the systematic improvements in the test items, the gas sampling procedures, the unit protecting interlock, and the facility protecting logic. For the trial run design, establishment has been implemented on the efficient and functional test plans by establishing priority on the tests to be executed, so that the development items demanded in the pilot test and research can be achieved within the limited test processes. (NEDO)

  13. Constructing Catalonia

    Directory of Open Access Journals (Sweden)

    Bill Philips

    2009-07-01

    Full Text Available Catalonia, in common with other nations, has long been concerned with the question of identity and difference. Its problematic relationship with Spain has led to an emphasis on differentiating itself from its larger neighbour (if we are to accept, as most Spaniards do not, that Catalonia is not Spain, a situation complicated by the loss of the Spanish colonies of Cuba and The Philippines in 1898, and the Spanish Civil War and subsequent dictatorship from 1936 to 1976. Beginning in the late nineteenth century, the construction of a Catalan identity followed a similar route to that taken by other European nations such as England, Ireland and, indeed, Spain, including an emphasis on rural values, activities and the countryside, and the conversion of specifically local traditions into national past times. It is only in the last ten years or so that this model of Catalan identity has been recognised for what it is – a model constructed and encouraged for and by specific nationalist political interests. Ironically, Catalonia’s identity abroad has also been constructed and manipulated for political purposes, but from quite a different perspective. Orwell’s /Homage to Catalonia/ (1938 narrates an extremely blinkered version of the Spanish Civil War which has achieved iconic status as a result of cold war politics. Subsequent portrayals of the Spanish Civil War – Valentine Cunningham’s /The Penguin Book of Spanish Civil War Verse/ (ed., Penguin, 1980, or Ken Loach’s 1995 film /Land and Freedom/ base their arguments unquestioningly on /Homage to Catalonia/, perpetuating a view of the nation’s recent history that is both reductive and inaccurate

  14. Analyzing Compliance Rate of Intended Andimplemented Curriculum Of Research And Thinking Textbook In Sixth Elementary Grade In Maidenly Schools Of Urmia City In Iran

    OpenAIRE

    Tayefeh E; Sheikhzadeh M

    2014-01-01

    This research tries to present a general image of compliance and consistency rate of implemented and intended curriculum in research and thinking textbook of elementary sixth grade in Iran according to its four major elements. Research is descriptive- survey type. Statistical population contains all elementary sixth grade teachers of maidenly schools in Urmia city. Research’s statistical samples are 102 elementary sixth grade teachers that are selected as simple random- classified sampling. R...

  15. Layout Construction

    DEFF Research Database (Denmark)

    Frandsen, Gudmund Skovbjerg; Palsberg, Jens; Schmidt, Erik Meineche

    We design a system for generating newspaper layout proposals. The input to the system consists of editorial information (text, pictures, etc) and style information (non-editorial information that specifies the aesthetic appearance of a layout). We consider the automation of layout construction...... to pose two main problems. One problem consists in optimizing the layout with respect to the constraints and preferences specified in the style information. Another problem consists in finding a representation of the style information that both supports its use in the combinatorial optimization...

  16. Teaching secondary science constructing meaning and developing understanding

    CERN Document Server

    Ross, Keith; McKechnie, Janet

    2010-01-01

    Now fully updated in its third edition Teaching Secondary Science is a comprehensive guide to all aspects of science teaching, providing a wealth of information and ideas about different approaches. With guidance on how children understand scientific ideas and the implications this has on teaching, teachers are encouraged to construct their own meanings and become reflective in their practice. Relating science to government agendas, such as the National Strategies, Assessment for Learning and Every Child Matters, this new edition reflects and maps to changes in national standards. Ke

  17. Wireline logging tool catalog; 2nd edition

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    This catalog facilitates wireline logging by (1) drawing up programs, (2) showing the adaptation of tools to downhole conditions, drilling fluids, and formations to be measured, and (3) monitoring operations such as recording speeds and calibration control. This edition now represents the tools and services of five additional companies beyond the two companies in the first edition. The participating companies are: BPB Instrument Ltd, Dresser Atlas, Gearhart Geoservices, Micro Log, Prakla Seismos, Schlumberger, and Welex. For quick consultation of the catalog, the tools are classified by ''families.'' For each family of tools, there is a background to the technology and an explanation of the principles of measurement and applications, along with examples of recorded curves. Case documents submitted by service companies include technical data sheets, sketches of tools and their main combinations, and examples of calibration

  18. Handbook of radioactivity analysis. Second edition

    International Nuclear Information System (INIS)

    L'Annunziata, M.

    2003-07-01

    This updated and much expanded Second Edition is an authoritative handbook providing the principles, practical techniques, and procedures for the accurate measurement of radioactivity from the very low levels encountered in the environment to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, fuel cycle facilities, and in the implementation of nuclear safeguards. The book describes the preparation of samples from a wide variety of matrices, assists the investigator or technician in the selection and use of appropriate radiation detectors, and presents state-of-the-art methods of analysis. Fundamentals of radioactivity properties, radionuclide decay, the calculations involved, and methods of detection provide the basis for a thorough understanding of the analytical procedures. The Handbook of Radioactivity Analysis, Second Edition is suitable as a teaching text for university and professional training courses

  19. Transportation Energy Data Book, Edition 18

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy C.

    1998-09-01

    The Transportation Energy Data Book: Edition 18 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. This edition of the Data Book has 11 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy Chapter 3 - emissions; Chapter 4 - transportation and the economy; Chapter 5 - highway vehicles; Chapter 6 - Light vehicles; Chapter 7 - heavy vehicles; Chapter 8 - alternative fuel vehicles; Chapter 9 - fleet vehicles; Chapter 10 - household vehicles; and Chapter 11 - nonhighway modes. The sources used represent the latest available data.

  20. Migration and Remittances Factbook 2016, Third Edition

    OpenAIRE

    World Bank Group

    2016-01-01

    The Migration and Remittances Factbook 2016 attempts to present numbers and facts behind the stories of international migration and remittances, drawing on authoritative, publicly available data. It provides a snapshot of statistics on immigration, emigration, skilled emigration, and remittance flows for 210 countries and 15 regional and income groups. The Migration and Remittances Factbook 2016 updates the 2011 edition of the Factbook with additional data on bilateral migration and remittanc...

  1. Geometry of Graph Edit Distance Spaces

    OpenAIRE

    Jain, Brijnesh J.

    2015-01-01

    In this paper we study the geometry of graph spaces endowed with a special class of graph edit distances. The focus is on geometrical results useful for statistical pattern recognition. The main result is the Graph Representation Theorem. It states that a graph is a point in some geometrical space, called orbit space. Orbit spaces are well investigated and easier to explore than the original graph space. We derive a number of geometrical results from the orbit space representation, translate ...

  2. CERN Video News, 2nd edition

    CERN Multimedia

    2002-01-01

    This week you will be able to watch on the web the second edition of CERN's video news (see Bulletin n°45/2002, p.3). On this news reel: the ATRAP experiment's latest achievements, superconducting cable production for CMS, the CAST experiment and the European digital conferencing project InDiCo. Go to : www.cern.ch/video, or Bulletin web page.

  3. European Code against Cancer 4th Edition

    DEFF Research Database (Denmark)

    Friis, Søren; Kesminiene, Ausrele; Espina, Carolina

    2015-01-01

    The 4th edition of the European Code against Cancer recommends limiting - or avoiding when possible - the use of hormone replacement therapy (HRT) because of the increased risk of cancer, nevertheless acknowledging that prescription of HRT may be indicated under certain medical conditions. Current...... health benefits; however, prudent practices need to be in place, with procedures and techniques providing the needed diagnostic information or therapeutic gain with the lowest possible radiation exposure. For pharmaceutical drugs and medical radiation exposure with convincing evidence...

  4. Transportation Energy Data Book: Edition 26

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL

    2007-07-01

    The Transportation Energy Data Book: Edition 26 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy; Chapter 3 - highway vehicles; Chapter 4 - light vehicles; Chapter 5 - heavy vehicles; Chapter 6 - alternative fuel vehicles; Chapter 7 - fleet vehicles; Chapter 8 - household vehicles; and Chapter 9- nonhighway modes; Chapter 10 - transportation and the economy; Chapter 11 - greenhouse gas emissions; and Chapter 12 - criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  5. Transportation Energy Data Book: Edition 21; TOPICAL

    International Nuclear Information System (INIS)

    Davis, SC

    2001-01-01

    The Transportation Energy Data Book: Edition 21 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www-cta.ornl.gov/data/tedb.htm). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2-energy; Chapter 3-greenhouse gas emissions; Chapter 4-criteria pollutant emissions; Chapter 5-transportation and the economy; Chapter 6-highway vehicles; Chapter 7-light vehicles; Chapter 8-heavy vehicles; Chapter 9-alternative fuel vehicles; Chapter 10-fleet vehicles; Chapter 11-household vehicles; and Chapter 12-nonhighway modes. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience

  6. ADAR RNA editing below the backbone.

    Science.gov (United States)

    Keegan, Liam; Khan, Anzer; Vukic, Dragana; O'Connell, Mary

    2017-09-01

    ADAR RNA editing enzymes ( a denosine d e a minases acting on R NA) that convert adenosine bases to inosines were first identified biochemically 30 years ago. Since then, studies on ADARs in genetic model organisms, and evolutionary comparisons between them, continue to reveal a surprising range of pleiotropic biological effects of ADARs. This review focuses on Drosophila melanogaster , which has a single Adar gene encoding a homolog of vertebrate ADAR2 that site-specifically edits hundreds of transcripts to change individual codons in ion channel subunits and membrane and cytoskeletal proteins. Drosophila ADAR is involved in the control of neuronal excitability and neurodegeneration and, intriguingly, in the control of neuronal plasticity and sleep. Drosophila ADAR also interacts strongly with RNA interference, a key antiviral defense mechanism in invertebrates. Recent crystal structures of human ADAR2 deaminase domain-RNA complexes help to interpret available information on Drosophila ADAR isoforms and on the evolution of ADARs from tRNA deaminase ADAT proteins. ADAR RNA editing is a paradigm for the now rapidly expanding range of RNA modifications in mRNAs and ncRNAs. Even with recent progress, much remains to be understood about these groundbreaking ADAR RNA modification systems. © 2017 Keegan et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  7. Handbook of Adhesion, 2nd Edition

    Science.gov (United States)

    Packham, D. E.

    2005-06-01

    This second edition of the successful Handbook of Adhesion provides concise and authoritative articles covering many aspects of the science and technology associated with adhesion and adhesives. It is intended to fill a gap between the necessarily simplified treatment of the student textbook and the full and thorough treatment of the research monograph and review article. The articles are structured in such a way, with internal cross-referencing and external literature references, that the reader can build up a broader and deeper understanding, as their needs require. This second edition includes many new articles covering developments which have risen in prominence in the intervening years, such as scanning probe techniques, the surface forces apparatus and the relation between adhesion and fractal surfaces. Advances in understanding polymer - polymer interdiffusion are reflected in articles drawing out the implications for adhesive bonding. In addition, articles derived from the earlier edition have been revised and updated where needed. Throughout the book there is a renewed emphasis on environmental implications of the use of adhesives and sealants. The scope of the Handbook, which features nearly 250 articles from over 60 authors, includes the background science - physics, chemistry and material science - and engineering, and also aspects of adhesion relevant to the use of adhesives, including topics such as: Sealants and mastics Paints and coatings Printing and composite materials Welding and autohesion Engineering design The Handbook of Adhesion is intended for scientists and engineers in both academia and industry, requiring an understanding of the various facets of adhesion.

  8. Transportation Energy Data Book: Edition 36

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Susan E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Davis, Stacy Cagle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boundy, Robert Gary [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-12-01

    The Transportation Energy Data Book: Edition 36 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 – energy; Chapter 3 – highway vehicles; Chapter 4 – light vehicles; Chapter 5 – heavy vehicles; Chapter 6 – alternative fuel vehicles; Chapter 7 – fleet vehicles; Chapter 8 – household vehicles; Chapter 9 – nonhighway modes; Chapter 10 – transportation and the economy; Chapter 11 – greenhouse gas emissions; and Chapter 12 – criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms is also included for the reader’s convenience.

  9. Transportation Energy Data Book: Edition 24

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2005-03-08

    The ''Transportation Energy Data Book: Edition 24'' is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2--energy; Chapter 3--highway vehicles; Chapter 4--light vehicles; Chapter 5--heavy vehicles; Chapter 6--alternative fuel vehicles; Chapter 7--fleet vehicles; Chapter 8--household vehicles; and Chapter 9--nonhighway modes; Chapter 10--transportation and the economy; Chapter 11--greenhouse gas emissions; and Chapter 12--criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  10. Transportation Energy Data Book: Edition 23

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2003-10-24

    The ''Transportation Energy Data Book: Edition 23'' is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www-cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2--energy; Chapter 3--highway vehicles; Chapter 4--light vehicles; Chapter 5--heavy vehicles; Chapter 6--alternative fuel vehicles; Chapter 7--fleet vehicles; Chapter 8--household vehicles; and Chapter 9--nonhighway modes; Chapter 10--transportation and the economy; Chapter 11--greenhouse gas emissions; and Chapter 12--criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  11. Transportation Energy Data Book: Edition 27

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2008-06-01

    The Transportation Energy Data Book: Edition 27 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; and Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  12. Transportation Energy Data Book: Edition 28

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2009-06-01

    The Transportation Energy Data Book: Edition 28 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with U.S Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program and the Hydrogen, Fuel Cells, and Infrastructure Technologies Program. Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; and Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  13. Transportation Energy Data Book: Edition 31

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2012-08-01

    The Transportation Energy Data Book: Edition 31 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  14. Transportation Energy Data Book: Edition 30

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2011-07-01

    The Transportation Energy Data Book: Edition 30 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  15. Transportation Energy Data Book: Edition 29

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2010-07-01

    The Transportation Energy Data Book: Edition 29 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  16. Transportation Energy Data Book: Edition 32

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2013-08-01

    The Transportation Energy Data Book: Edition 32 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  17. Transportation Energy Data Book: Edition 21

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2001-09-13

    The ''Transportation Energy Data Book: Edition 21'' is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www-cta.ornl.gov/data/tedb.htm). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2--energy; Chapter 3--greenhouse gas emissions; Chapter 4--criteria pollutant emissions; Chapter 5--transportation and the economy; Chapter 6--highway vehicles; Chapter 7--light vehicles; Chapter 8--heavy vehicles; Chapter 9--alternative fuel vehicles; Chapter 10--fleet vehicles; Chapter 11--household vehicles; and Chapter 12--nonhighway modes. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  18. Transportation Energy Data Book: Edition 22

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy C.; Diegel, Susan W.

    2002-12-04

    The Transportation Energy Data Book: Edition 22 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www.cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy; Chapter 3 - greenhouse gas emissions; Chapter 4 - criteria pollutant emissions; Chapter 5 - transportation and the economy; Chapter 6 - highway vehicles; Chapter 7 - light vehicles; Chapter 8 - heavy vehicles; Chapter 9 - alternative fuel vehicles; Chapter 10 - fleet vehicles; Chapter 11 - household vehicles; and Chapter 12- nonhighway modes. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  19. Transportation Energy Data Book: Edition 25

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL

    2006-06-01

    The Transportation Energy Data Book: Edition 25 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy; Chapter 3 - highway vehicles; Chapter 4 - light vehicles; Chapter 5 - heavy vehicles; Chapter 6 - alternative fuel vehicles; Chapter 7 - fleet vehicles; Chapter 8 - household vehicles; and Chapter 9- nonhighway modes; Chapter 10 - transportation and the economy; Chapter 11 - greenhouse gas emissions; and Chapter 12 - criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  20. Transportation Energy Data Book (Edition 20)

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2000-10-09

    The ''Transportation Energy Data Book: Edition 20'' is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www-cta.ornl.gov/data/tedb.htm). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2--energy; Chapter 3--greenhouse gas emissions; Chapter 4--criteria pollutant emissions; Chapter 5--transportation and the economy; Chapter 6--highway vehicles; Chapter 7--light vehicles; Chapter 8--heavy vehicles; Chapter 9--alternative fuel vehicles; Chapter 10--fleet vehicles; Chapter 11--household vehicles; and Chapter 12--nonhighway modes. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.